Science.gov

Sample records for operational approach combining

  1. Combined vaginoplasty technique for male-to-female sex reassignment surgery: Operative approach and outcomes.

    PubMed

    Papadopulos, Nikolaos A; Zavlin, Dmitry; Lellé, Jean-Daniel; Herschbach, Peter; Henrich, Gerhard; Kovacs, Laszlo; Ehrenberger, Benjamin; Machens, Hans-Guenther; Schaff, Juergen

    2017-10-01

    Several therapy options exist for male-to-female (MTF) transgenders desiring sex reassignment. Surgery includes numerous different procedures. Of those, vaginoplasty is predominant and aims at providing attractive esthetics and fully functional genitals. This study aimed to present the surgical results of our modified combined vaginoplasty technique in a consecutive patient cohort. We included 40 MTF transgender patients who underwent a two-stage sex reassignment surgery (SRS) in an observational prospective study between September 2012 and January 2014. Demographic characteristics, medical and surgical history, operative details, and outcomes after surgery were documented. Postoperatively, 23 patients received a pelvic examination following the standardized protocol. Measured vaginal depth was 11.77-14.99 cm depending on the size of the dilator used (25-40 mm). Vaginal, clitoral, and labial sensitivities were intact and favorable in all examined patients. Nineteen women (47.5%) opted for breast augmentations to achieve a feminine cosmesis, making it the most common nongenital operation. Complications were mostly minor and temporary. Severe adverse events, such as wound infections (n = 3), colon injuries (3), short (1) or narrow (1) vaginas, or partial clitoral necroses (1), were rare and immediately addressed by the surgical team. No vaginal construction was lost, and no secondary reconstructive approaches were required. Satisfactory physical results and favorable low rates of complications endorse our combined technique for MTF SRS. These findings, however, need to be confirmed by other research groups as well. Therefore, in our opinion, MTF SRS remains an evolving area of development, whose research is aiming to establish a state-of-the-art surgical technique. Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  2. Combined operative technique with anterior surgical approach and video-assisted thoracoscopic surgical lobectomy for anterior superior sulcus tumours.

    PubMed

    Yokoyama, Yuhei; Chen, Fengshi; Aoyama, Akihiro; Sato, Toshihiko; Date, Hiroshi

    2014-11-01

    Video-assisted thoracoscopic surgery (VATS) has been widely used, but surgical resections of superior sulcus tumours remain challenging because of their anatomical location. For such cases, less-invasive procedures, such as the anterior transcervical-thoracic and transmanubrial approaches, have been widely performed because of their excellent visualization of the subclavian vessels. Recently, a combined operative technique with an anterior surgical approach and VATS for anterior superior sulcus tumours has been introduced. Herein, we report three cases of anterior superior sulcus tumours successfully resected by surgical approaches combined with a VATS-based lobectomy. In all cases, operability was confirmed by VATS, and upper lobectomies with hilar and mediastinal lymph node dissections were performed. Subsequently, dissections of the anterior inlet of the tumours were performed using the transmanubrial approach in two patients and the anterior trans-cervical-thoracic approach in one patient. Both approaches provided excellent access to the anterior inlet of the tumour and exposure of the subclavian vessels, resulting in radical resection of the tumour with concomitant resection of the surrounding anatomical structures, including the chest wall and vessels. In conclusion, VATS lobectomy combined with the anterior surgical approach might be an excellent procedure for the resection of anterior superior sulcus tumours.

  3. Interoperability and Combined Operations.

    DTIC Science & Technology

    1981-06-15

    34Organization for Joint Operations," MIL RVW, 32:32-39, Feb 1953. Collins, Joseph L. "Building Strength for Western Defense," AID, 9:3-8, Jul 1954...34 MIL RVW, 26:3-9, Aug 1946; 26:10-16, Sep 1946. Johnston, Joseph W. "Combined Operations in Lower Units," MIL RVW, 32:56-62, Jul 1952. Lenschau...1950. Postlethwait, Edward M. "Unified Command in Theaters of Operations," MIL RVW, 29:23-30, Nov 1949. Priestley , H. "Let’s Stick Together," MIL RVW

  4. Intelligence Fusion for Combined Operations

    DTIC Science & Technology

    1994-06-03

    doctrine on intelligence in combined operations, the lessons learned from the most recent combined operations, the current state of intelligence fision ...control of nuclear weapons and arms proliferation in the former Soviet Union.’ In Asia, the United States maintains a military presence in support of...emanating from other than nuclear or radioactive sources. Individual Reports Database - The portion of the LOCE database consisting of entity data records

  5. Combined approach brings success.

    PubMed

    Law, Oliver

    2014-06-01

    Sixteen months ago, according to Trumpf Medical Systems, which managed the project, 'something out of the ordinary' happened at Leighton Hospital in Crewe. When making plans to upgrade ageing operating theatres and critical care units, the estates department took the decision to involve other disciplines from the very start of the process. Clinicians, nursing staff, architects, patient representatives, and suppliers, all played their part, with the estates team always at the hub. As Oliver Law, managing director of the UK medical technology specialist, explains, this multidisciplinary approach had a profound effect on the outcome.

  6. A combined spectral and object-based approach to transparent cloud removal in an operational setting for Landsat ETM+

    NASA Astrophysics Data System (ADS)

    Watmough, Gary R.; Atkinson, Peter M.; Hutton, Craig W.

    2011-04-01

    The automated cloud cover assessment (ACCA) algorithm has provided automated estimates of cloud cover for the Landsat ETM+ mission since 2001. However, due to the lack of a band around 1.375 μm, cloud edges and transparent clouds such as cirrus cannot be detected. Use of Landsat ETM+ imagery for terrestrial land analysis is further hampered by the relatively long revisit period due to a nadir only viewing sensor. In this study, the ACCA threshold parameters were altered to minimise omission errors in the cloud masks. Object-based analysis was used to reduce the commission errors from the extended cloud filters. The method resulted in the removal of optically thin cirrus cloud and cloud edges which are often missed by other methods in sub-tropical areas. Although not fully automated, the principles of the method developed here provide an opportunity for using otherwise sub-optimal or completely unusable Landsat ETM+ imagery for operational applications. Where specific images are required for particular research goals the method can be used to remove cloud and transparent cloud helping to reduce bias in subsequent land cover classifications.

  7. A combined experimental and numerical approach for the control and monitoring of the SPES target during operation at high temperature

    NASA Astrophysics Data System (ADS)

    Ballan, Michele; Manzolaro, Mattia; Meneghetti, Giovanni; Andrighetto, Alberto; Monetti, Alberto; Bisoffi, Giovanni; Prete, Gianfranco

    2016-06-01

    The SPES project at INFN-LNL aims at the production of neutron-rich Radioactive Ion Beams (RIBs) using the ISOL (Isotope Separation On Line) technique. A 40 MeV 200 μA proton beam will directly impinge a uranium carbide target, generating approximately 1013 fissions per second. The target system is installed under vacuum inside a water-cooled chamber, and have to maintain high working temperatures, close to 2000 °C. During operation the proton beam provides the heating power required to keep the target at the desired temperature level. As a consequence, its characteristics have to be strictly controlled in order to avoid undesired overheating. According to the original design of the control system, the proton beam can be suddenly interrupted in case of out of range vacuum or cooling water flow levels. With the aim to improve the reliability of the control system a set of temperature sensors has been installed close to the target. Their types and installation positions were defined taking into consideration the detailed information coming from a dedicated thermal-electric model that allowed to investigate the most critical and inaccessible target hot-spots. This work is focused on the definition and experimental validation of the aforementioned numerical model. Its results were used to appropriately install two type C thermocouples, a PT100 thermo-resistance and a residual primary beam current detector. In addition the numerical model will be used for the definition of appropriate thresholds for each installed temperature sensor, since it allows to define a relationship between the locally measured values with the overall calculated temperature field. In case of over temperatures the monitoring system will send warning signals or in case interrupt the proton beam.

  8. Combined state-adding and state-deleting approaches to type III multi-step rationally extended potentials: Applications to ladder operators and superintegrability

    SciTech Connect

    Marquette, Ian; Quesne, Christiane

    2014-11-15

    Type III multi-step rationally extended harmonic oscillator and radial harmonic oscillator potentials, characterized by a set of k integers m{sub 1}, m{sub 2}, ⋯, m{sub k}, such that m{sub 1} < m{sub 2} < ⋯ < m{sub k} with m{sub i} even (resp. odd) for i odd (resp. even), are considered. The state-adding and state-deleting approaches to these potentials in a supersymmetric quantum mechanical framework are combined to construct new ladder operators. The eigenstates of the Hamiltonians are shown to separate into m{sub k} + 1 infinite-dimensional unitary irreducible representations of the corresponding polynomial Heisenberg algebras. These ladder operators are then used to build a higher-order integral of motion for seven new infinite families of superintegrable two-dimensional systems separable in cartesian coordinates. The finite-dimensional unitary irreducible representations of the polynomial algebras of such systems are directly determined from the ladder operator action on the constituent one-dimensional Hamiltonian eigenstates and provide an algebraic derivation of the superintegrable systems whole spectrum including the level total degeneracies.

  9. Major Joint/Combined Operations

    DTIC Science & Technology

    2008-01-01

    engagements, strikes) conducted by various combat forces of a single or several services, coordinated in time and place to accomplish an...operational and sometimes strategic objective in an operational area. These actions are conducted simultaneously or sequentially in accordance with a common...In generic terms, a major operation can be described as consisting of a series of related major and minor tactical actions by two or more combat

  10. A combined approach for a better understanding of wastewater treatment plants operation: statistical analysis of monitoring database and sludge physico-chemical characterization.

    PubMed

    Avella, A C; Görner, T; Yvon, J; Chappe, P; Guinot-Thomas, P; de Donato, Ph

    2011-01-01

    Biological wastewater treatment plants (WWTP) are complex systems to assess. Many parameters are recorded daily in WWTP to monitor and control the treatment process, providing huge amounts of registered data. A combined approach of extracting information from the WWTP databases by statistical methods and from the sludge physico-chemical characterization was used here for a better understanding of the WWTP operation. The monitored parameters were analysed by multivariate statistical methods: Principal Components Analysis and multiple partial linear regression. The WWTP operational conditions determine the sludge characteristics. The bacterial activity of the sludge in terms of extra-cellular polymeric substances (EPS) production was assessed using size exclusion chromatography and the internal structure of sludge flocs was observed by confocal laser scanning microscopy. The diagnosis of three paper mill WWTP enabled the identification of an important EPS production, the presence of the nitrification process and the presence of PO(4)(3-) nutrient in WWTP-A. These three main characteristics of WWTP-A were related with a systematically good sludge settling. In WWTP-B and C with bad settling, the bacterial activity was weak. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. A rapid application of GA-MODFLOW combined approach to optimization of well placement and operation for drought-ready groundwater reservoir design

    NASA Astrophysics Data System (ADS)

    Park, C.; Kim, Y.; Jang, H.

    2016-12-01

    Poor temporal distribution of precipitation increases winter drought risks in mountain valley areas in Korea. Since perennial streams or reservoirs for water use are rare in the areas, groundwater is usually a major water resource. Significant amount of the precipitation contributing groundwater recharge mostly occurs during the summer season. However, a volume of groundwater recharge is limited by rapid runoff because of the topographic characteristics such as steep hill and slope. A groundwater reservoir using artificial recharge method with rain water reuse can be a suitable solution to secure water resource for the mountain valley areas. Successful groundwater reservoir design depends on optimization of well placement and operation. This study introduces a combined approach using GA (Genetic Algorithm) and MODFLOW and its rapid application. The methodology is based on RAD (Rapid Application Development) concept in order to minimize the cost of implementation. DEAP (Distributed Evolutionary Algorithms in Python), a framework for prototyping and testing evolutionary algorithms, is applied for quick code development and CUDA (Compute Unified Device Architecture), a parallel computing platform using GPU (Graphics Processing Unit), is introduced to reduce runtime. The application was successfully applied to Samdeok-ri, Gosung, Korea. The site is located in a mountain valley area and unconfined aquifers are major source of water use. The results of the application produced the best location and optimized operation schedule of wells including pumping and injecting.

  12. Combining empirical approaches and error modelling to enhance predictive uncertainty estimation in extrapolation for operational flood forecasting. Tests on flood events on the Loire basin, France.

    NASA Astrophysics Data System (ADS)

    Berthet, Lionel; Marty, Renaud; Bourgin, François; Viatgé, Julie; Piotte, Olivier; Perrin, Charles

    2017-04-01

    An increasing number of operational flood forecasting centres assess the predictive uncertainty associated with their forecasts and communicate it to the end users. This information can match the end-users needs (i.e. prove to be useful for an efficient crisis management) only if it is reliable: reliability is therefore a key quality for operational flood forecasts. In 2015, the French flood forecasting national and regional services (Vigicrues network; www.vigicrues.gouv.fr) implemented a framework to compute quantitative discharge and water level forecasts and to assess the predictive uncertainty. Among the possible technical options to achieve this goal, a statistical analysis of past forecasting errors of deterministic models has been selected (QUOIQUE method, Bourgin, 2014). It is a data-based and non-parametric approach based on as few assumptions as possible about the forecasting error mathematical structure. In particular, a very simple assumption is made regarding the predictive uncertainty distributions for large events outside the range of the calibration data: the multiplicative error distribution is assumed to be constant, whatever the magnitude of the flood. Indeed, the predictive distributions may not be reliable in extrapolation. However, estimating the predictive uncertainty for these rare events is crucial when major floods are of concern. In order to improve the forecasts reliability for major floods, an attempt at combining the operational strength of the empirical statistical analysis and a simple error modelling is done. Since the heteroscedasticity of forecast errors can considerably weaken the predictive reliability for large floods, this error modelling is based on the log-sinh transformation which proved to reduce significantly the heteroscedasticity of the transformed error in a simulation context, even for flood peaks (Wang et al., 2012). Exploratory tests on some operational forecasts issued during the recent floods experienced in

  13. Transanal minimally invasive surgery for total mesorectal excision (ETM) through transanal approach (TaETM) with robotic and Transanal Endoscopic Operations (TEO) combined access: step by step surgery.

    PubMed

    Mendes, Carlos Ramon Silveira; Valadão, Marcus; Araújo, Rodrigo; Linhares, Eduardo; Jesus, José Paulo

    2015-01-01

    In the treatment of colorectal cancer, from 1982 Heald proposed standardization of the total mesorectal excision, with a significant reduction in the recurrence rate. But the treatment of lower rectal lesions is still a challenge. To describe the association of robotic low anterior resection- TATA (Transanal Abdominal Transanal Resection), with transanal access using Transanal Endoscopic Operations - TEO in the treatment of lower rectal cancer. The TATA performs robotic abdominal approach and the TEO performs the perineal approach, developing total mesorectal excision (TME) transanally (TaETM). The TaETM technique was applied in a woman with rectal adenocarcinoma 5 cm from the anal verge that had been submitted to chemoradiation. The procedure was performed with satisfatory operative time and favorable oncological outcome (grade 3 mesorectal excision). This is a promising minimally invasive procedure in the armamentarium of rectal cancer treatment, specially in challenging scenarios such as narrow pelvis, obesity and very low rectal tumors.

  14. Diffraction operators in paraxial approach

    NASA Astrophysics Data System (ADS)

    Lasso, William; Navas, Marianela; Añez, Liz; Urdaneta, Romer; Díaz, Leonardo; Torres, César O.

    2014-07-01

    Nowadays, research in the field of science education points to the creation of alternative ways of teaching contents encouraging the development of more elaborate reasoning, where a high degree of abstraction and generalization of scientific knowledge prevails. On that subject, this research shows a didactic alternative proposal for the construction of Fresnel and Fraunhoffer diffraction concepts applying the Fourier transform technique in the study of electromagnetic waves propagation in free space. Curvature transparency and Fourier sphere operators in paraxial approximation are used in order to make the usual laborious mathematical approach easier. The main result shows that the composition of optic metaxial operators results in the discovery of a simpler way out of the standard electromagnetic wave propagation in free space between a transmitter and a receptor separated from a given distance. This allows to state that the didactic proposal shown encourages the construction of Fresnel and Fraunhoffer diffraction concepts in a more effective and easier way than the traditional teaching.

  15. Combined Special Operations in World War 2

    DTIC Science & Technology

    1993-05-09

    related literature reveals that publications covering the role of combined special operations are limited but not exclusive. In the Watery Maze: A Story...Montgomery, Alabama, 1982 DTIG ELECTE ~ ’JNOV 17 1993 AFort Leavenworth, Kansas 1993 Approved for public release; distribution is unlimited. S93-28070 -A70 0...STATEMENT 12b. DISTRIBUTION CODE Approved for Public Release; distribution is unlimited. 13. ABSTRACT (MaAlmumn 200 words) This study is an historical

  16. Combined Operations a Commonwealth Caribbean Perspective

    DTIC Science & Technology

    1988-06-03

    America and the Caribbeanr 0 exC~ S , slnl estnOC NORTH*,a* I SUEldraasI Cal slnd A. TO.-, T HE 󈧐 C., Sillsan BAHAMAS Olti BCAAS ," Great’ f, Ca...COMBINED OPERATIONS A COMMONWEALTH CARIBBEAN PERSPECTIVE A Thesis presented to the Faculty of the U. S . Army Command and General Staff College in... S A COMMONWEALTH CARIBBEAN PERSPECTIVE A Thesis presented to the Faculty of the U. S . Army Command and General Staff College in partial fulfillment

  17. Terrorist Approach to Information Operations

    DTIC Science & Technology

    2003-06-01

    how they implement them to influence their target audiences. The thesis shows that terrorists are, indeed, naturally linked to the information...uncommitted, sympathetic, and active to influence their perceptions. 15. NUMBER OF PAGES 162 14. SUBJECT TERMS Information Operations...to IO theory. The framework proves useful in examining the IO tools terrorists have assembled and how they implement them to influence their target

  18. Night Operations - The Soviet Approach

    DTIC Science & Technology

    1978-06-09

    cannons 4 - 5 Muzzle flashes from small arms 1.5 - 2 Bonfire 6 - 8 Flashlight up to 1.5 Lighted match up to 1.5 Lighted cigarette up to .8 Audibility...60,,.6o d-o "NORM NOT GIVEN DIRECTORS-SQUAD COMMANDERS Figure 3 Firing Range DDT -1100-128-76, Soviet Ground Porces, Night Operations,tMarch 1976

  19. Operational algorithm development and refinement approaches

    NASA Astrophysics Data System (ADS)

    Ardanuy, Philip E.

    2003-11-01

    Next-generation polar and geostationary systems, such as the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and the Geostationary Operational Environmental Satellite (GOES)-R, will deploy new generations of electro-optical reflective and emissive capabilities. These will include low-radiometric-noise, improved spatial resolution multi-spectral and hyperspectral imagers and sounders. To achieve specified performances (e.g., measurement accuracy, precision, uncertainty, and stability), and best utilize the advanced space-borne sensing capabilities, a new generation of retrieval algorithms will be implemented. In most cases, these advanced algorithms benefit from ongoing testing and validation using heritage research mission algorithms and data [e.g., the Earth Observing System (EOS)] Moderate-resolution Imaging Spectroradiometer (MODIS) and Shuttle Ozone Limb Scattering Experiment (SOLSE)/Limb Ozone Retreival Experiment (LORE). In these instances, an algorithm's theoretical basis is not static, but rather improves with time. Once frozen, an operational algorithm can "lose ground" relative to research analogs. Cost/benefit analyses provide a basis for change management. The challenge is in reconciling and balancing the stability, and "comfort," that today"s generation of operational platforms provide (well-characterized, known, sensors and algorithms) with the greatly improved quality, opportunities, and risks, that the next generation of operational sensors and algorithms offer. By using the best practices and lessons learned from heritage/groundbreaking activities, it is possible to implement an agile process that enables change, while managing change. This approach combines a "known-risk" frozen baseline with preset completion schedules with insertion opportunities for algorithm advances as ongoing validation activities identify and repair areas of weak performance. This paper describes an objective, adaptive implementation roadmap that

  20. Differential operator approach for Fourier image processing.

    PubMed

    Núñez, Ismael; Ferrari, José A

    2007-08-01

    We present a differential operator approach for Fourier image processing. We demonstrate that when the mask in the processor Fourier plane is an analytical function, it can be described by means of a differential operator that acts directly on the input field to give the processed output image. In many cases (e.g., Schlieren imaging) this approach simplifies the calculations, which usually involve the evaluation of convolution integrals, and gives a new insight into the image-processing procedure.

  1. A correlational approach to predicting operator status

    NASA Technical Reports Server (NTRS)

    Shingledecker, Clark A.

    1988-01-01

    This paper discusses a research approach for identifying and validating candidate physiological and behavioral parameters which can be used to predict the performance capabilities of aircrew and other system operators. In this methodology, concurrent and advance correlations are computed between predictor values and criterion performance measures. Continuous performance and sleep loss are used as stressors to promote performance variation. Preliminary data are presented which suggest dependence of prediction capability on the resource allocation policy of the operator.

  2. Combining Concepts: Operational Shock in Insurgencies

    DTIC Science & Technology

    2013-05-23

    command nodes, and rail networks, denying the enemy the ability to operationally maneuver his forces.4 This rapid maneuver, coupled with attacks...insurgencies, each with unique aims and methods to achieve those aims. The models outlined in FM 3-24 are the Maoist, focoist, urban guerilla, and the...Thompson, a British veteran of Burma and the campaign in Malaysia wrote Countering Communist Insurgency. Frank Kitson, another British officer whose

  3. XV-15 Tiltrotor Low Noise Approach Operations

    NASA Technical Reports Server (NTRS)

    Conner, David A.; Marcolini, Michael A.; Decker, William A.; Cline, John H.; Edwards, Bryan D.; Nicks, Colby O.; Klein, Peter D.

    1999-01-01

    Acoustic data have been acquired for the XV-15 tiltrotor aircraft performing approach operations for a variety of different approach profile configurations. This flight test program was conducted jointly by NASA, the U.S. Army, and Bell Helicopter Textron, Inc. (BHTI) in June 1997. The XV-15 was flown over a large area microphone array, which was deployed to directly measure the noise footprint produced during actual approach operations. The XV-15 flew realistic approach profiles that culminated in IGE hover over a landing pad. Aircraft tracking and pilot guidance was provided by a Differential Global Positioning System (DGPS) and a flight director system developed at BHTI. Approach profile designs emphasized noise reduction while maintaining handling qualities sufficient for tiltrotor commercial passenger ride comfort and flight safety under Instrument Flight Rules (IFR) conditions. A discussion of the approach profile design philosophy is provided. Five different approach profiles are discussed in detail -- 3 deg., 6 deg., and 9 deg. approaches, and two very different 3 deg. to 9 deg. segmented approaches. The approach profile characteristics are discussed in detail, followed by the noise footprints and handling qualities. Sound exposure levels are also presented on an averaged basis and as a function of the sideline distance for a number of up-range distances from the landing point. A comparison of the noise contour areas is also provided. The results document the variation in tiltrotor noise due to changes in operating condition, and indicate the potential for significant noise reduction using the unique tiltrotor capability of nacelle tilt.

  4. Joint Training In Combined Entry Operations

    DTIC Science & Technology

    2014-02-13

    that address joint entry operations. The first of these exercises to be discussed is BOLD ALLIGATOR (BA). Beginning in 2008, the Chief of Naval...26 39 US Fleet Forces Command. Bold Alligator 2014 Factbook. Norfolk, VA: US Fleet Forces Command, 01 Oct 2014. 12 40 ibid, 12 41 ibid, 12, 19...42 Seck, Hope Hodge, “Next Live Bold Alligator Exercise Won’t Be Until 2017,” MarineCorps Times.com, 04 Feb 2015, http://www.marinecorpstimes.com

  5. Improving the Resilience of Major Ports and Critical Supply Chains to Extreme Coastal Flooding: a Combined Artificial Neural Network and Hydrodynamic Simulation Approach to Predicting Tidal Surge Inundation of Port Infrastructure and Impact on Operations.

    NASA Astrophysics Data System (ADS)

    French, J.

    2015-12-01

    Ports are vital to the global economy, but assessments of global exposure to flood risk have generally focused on major concentrations of population or asset values. Few studies have examined the impact of extreme inundation events on port operation and critical supply chains. Extreme water levels and recurrence intervals have conventionally been estimated via analysis of historic water level maxima, and these vary widely depending on the statistical assumptions made. This information is supplemented by near-term forecasts from operational surge-tide models, which give continuous water levels but at considerable computational cost. As part of a NERC Infrastructure and Risk project, we have investigated the impact of North Sea tidal surges on the Port of Immingham, eastern, UK. This handles the largest volume of bulk cargo in the UK and flows of coal and biomass that are critically important for national energy security. The port was partly flooded during a major tidal surge in 2013. This event highlighted the need for improved local forecasts of surge timing in relation to high water, with a better indication of flood depth and duration. We address this problem using a combination of data-driven and numerical hydrodynamic models. An Artificial Neural Network (ANN) is first used to predict the surge component of water level from meteorological data. The input vector comprises time-series of local wind (easterly and northerly wind stress) and pressure, as well as regional pressure and pressure gradients from stations between the Shetland Islands and the Humber estuary. The ANN achieves rms errors of around 0.1 m and can generate short-range (~ 3 to 12 hour) forecasts given real-time input data feeds. It can also synthesize water level events for a wider range of tidal and meteorological forcing combinations than contained in the observational records. These are used to force Telemac2D numerical floodplain simulations using a LiDAR digital elevation model of the port

  6. Combining accounting approaches to practice valuation.

    PubMed

    Schwartzben, D; Finkler, S A

    1998-06-01

    Healthcare organizations that wish to acquire physician or ambulatory care practices can choose from a variety of practice valuation approaches. Basic accounting methods assess the value of a physician practice on the basis of a historical, balance-sheet description of tangible assets. Yet these methods alone are inadequate to determine the true financial value of a practice. By using a combination of accounting approaches to practice valuation that consider factors such as fair market value, opportunity cost, and discounted cash flow over a defined time period, organizations can more accurately assess a practice's actual value.

  7. Intra-Operative Vertebroplasty Combined with Posterior Cord Decompression

    PubMed Central

    Allegretti, Luca; Mavilio, Nicola; Fiaschi, Pietro; Bragazzi, Roberto; Pacetti, Mattia; Castelletti, Lara; Saitta, Laura; Castellan, Lucio

    2014-01-01

    Summary Percutaneous vertebroplasty (VP) is a minimally invasive technique for the treatment of vertebral pathology providing early vertebral stabilization and pain relief. In cases of vertebral pathology complicated by spinal cord compression with associated neurological deficits, VP alone cannot be performed free of risks. We describe a combined approach in which decompressive laminectomy and intra-operative vertebroplasty (IVP) are performed during a single session. Among the 252 VP performed in our centre in the past three years, 12 patients (12 vertebral levels) with different pathologies (six symptomatic haemangiomas, two metastatic fractures, four osteoporotic fractures) were treated with an open procedure combined with surgery. All cases were treated with decompressive laminectomy and IVP (mono/bipeduncular or median-posterior trans-somatic access). Five patients with symptomatic haemangiomas were treated with endovascular embolization prior to the combined approach. A visual analogue scale (VAS) was applied to assess pain intensity before and after surgery. The neurological deficits were evaluated with an ASIA impairment scale. In all cases benefit from pain and neurological deficits was observed. The mean VAS score decreased from 7.8 to 2.5 after surgery. The ASIA score improved in all cases (five cases from D to E and five cases from C to D). No clinical complications were observed. In one case a CT scan performed after the procedure showed a foraminal accumulation of PMMA, but the patient referred no symptoms. IVP can be successfully applied in different pathologies affecting the vertebrae. In our limited series this approach proved safe and efficient to provide decompression of spinal cord and dural sac and vertebral body stabilization in a single session. PMID:25363261

  8. Algebraic operator approach to gas kinetic models

    NASA Astrophysics Data System (ADS)

    Il'ichov, L. V.

    1997-02-01

    Some general properties of the linear Boltzmann kinetic equation are used to present it in the form ∂ tϕ = - †Âϕ with the operators Âand† possessing some nontrivial algebraic properties. When applied to the Keilson-Storer kinetic model, this method gives an example of quantum ( q-deformed) Lie algebra. This approach provides also a natural generalization of the “kangaroo model”.

  9. Horizontal ridge augmentation using a combination approach

    PubMed Central

    Rachana, C.; Sridhar, N.; Rangan, Anand V.; Rajani, V.

    2012-01-01

    Resorption of alveolar bone - a common sequel of tooth loss jeopardizes the functional and esthetic outcome of treatment, especially in the maxillary anterior areas. Therefore, augmentation of deficient alveolar ridges is an important aspect of dental implant therapy. A case of severe maxillary ridge deficiency successfully treated with horizontal ridge augmentation to facilitate implant placement is described. Ridge augmentation was achieved using a combination of autogenous block graft, particulate grafting, and guided bone regeneration (GBR). Follow-up was done next day, after ten days, three months, and six months. Various approaches can be followed in order to achieve an increase in the ridge width. In our case, we used a combination of different techniques for ridge augmentation. A significant improvement in ridge width was noticed at six months thus facilitating the placement of implants. PMID:23162345

  10. Combined additive manufacturing approaches in tissue engineering.

    PubMed

    Giannitelli, S M; Mozetic, P; Trombetta, M; Rainer, A

    2015-09-01

    Advances introduced by additive manufacturing (AM) have significantly improved the control over the microarchitecture of scaffolds for tissue engineering. This has led to the flourishing of research works addressing the optimization of AM scaffolds microarchitecture to optimally trade-off between conflicting requirements (e.g. mechanical stiffness and porosity level). A fascinating trend concerns the integration of AM with other scaffold fabrication methods (i.e. "combined" AM), leading to hybrid architectures with complementary structural features. Although this innovative approach is still at its beginning, significant results have been achieved in terms of improved biological response to the scaffold, especially targeting the regeneration of complex tissues. This review paper reports the state of the art in the field of combined AM, posing the accent on recent trends, challenges, and future perspectives. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  11. EDOS operations concept and development approach

    NASA Technical Reports Server (NTRS)

    Knoble, G.; Garman, C.; Alcott, G.; Ramchandani, C.; Silvers, J.

    1994-01-01

    The Earth Observing System (EOS) Data and Operations System (EDOS) is being developed by the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) for the capture, level zero processing, distribution, and backup archiving of high speed telemetry data received from EOS spacecraft. All data received will conform to the Consultative Committee for Space Data Standards (CCSDS) recommendations. The major EDOS goals are to: (1) minimize EOS program costs to implement and operate EDOS; (2) respond effectively to EOS growth requirements; and (3) maintain compatibility with existing and enhanced versions of NASA institutional systems required to support EOS spacecraft. In order to meet these goals, the following objectives have been defined for EDOS: (1) standardize EDOS interfaces to maximize utility for future requirements; (2) emphasize life-cycle cost (LCC) considerations (rather than procurement costs) in making design decisions and meeting reliability, maintainability, availability (RMA) and upgradability requirements; (3) implement data-driven operations to the maximum extent possible to minimize staffing requirements and to maximize system responsiveness; (4) provide a system capable of simultaneously supporting multiple spacecraft, each in different phases of their life-cycles; (5) provide for technology insertion features to accommodate growth and future LCC reductions during the operations phase; and (6) provide a system that is sufficiently robust to accommodate incremental performance upgrades while supporting operations. Operations concept working group meetings were facilitated to help develop the EDOS operations concept. This provided a cohesive concept that met with approval of responsible personnel from the start. This approach not only speeded up the development process by reducing review cycles, it also provided a medium for generating good ideas that were immediately molded into feasible concepts. The operations concept

  12. Modelling approaches for bio-manufacturing operations.

    PubMed

    Chhatre, Sunil

    2013-01-01

    Fast and cost-effective methods are needed to reduce the time and money needed for drug commercialisation and to determine the risks involved in adopting specific manufacturing strategies. Simulations offer one such approach for exploring design spaces before significant process development is carried out and can be used from the very earliest development stages through to scale-up and optimisation of operating conditions and resource deployment patterns both before and after plant start-up. The advantages this brings in terms of financial savings can be considerable, but to achieve these requires a full appreciation of the complexities of processes and how best to represent them mathematically within the context of in silico software. This chapter provides a summary of some of the work that has been carried out in the areas of mathematical modelling and discrete event simulations for production, recovery and purification operations when designing bio-pharmaceutical processes, looking at both financial and technical modelling.

  13. Operator approach to boundary Liouville theory

    SciTech Connect

    Dorn, Harald Jorjadze, George

    2008-11-15

    We propose new methods for calculation of the discrete spectrum, the reflection amplitude and the correlation functions of boundary Liouville theory on a strip with Lorentzian signature. They are based on the structure of the vertex operator V=e{sup -{phi}} in terms of the asymptotic operators. The methods first are tested for the particle dynamics in the Morse potential, where similar structures appear. Application of our methods to boundary Liouville theory reproduces the known results obtained earlier in the bootstrap approach, but there can arise a certain extension when the boundary parameters are near to critical values. Namely, in this case we have found up to four different equidistant series of discrete spectra, and the reflection amplitude is modified, respectively.

  14. 10 CFR 52.103 - Operation under a combined license.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee shall... allegedly affected by the petition (fuel loading, low power testing, etc.) commences, the Commission shall...

  15. 10 CFR 52.103 - Operation under a combined license.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee shall... allegedly affected by the petition (fuel loading, low power testing, etc.) commences, the Commission shall...

  16. 10 CFR 52.103 - Operation under a combined license.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee shall... allegedly affected by the petition (fuel loading, low power testing, etc.) commences, the Commission shall...

  17. 10 CFR 52.103 - Operation under a combined license.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee shall... allegedly affected by the petition (fuel loading, low power testing, etc.) commences, the Commission shall...

  18. 10 CFR 52.103 - Operation under a combined license.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Combined Licenses § 52.103 Operation under a combined license. (a) The licensee shall... allegedly affected by the petition (fuel loading, low power testing, etc.) commences, the Commission shall...

  19. Prediction of a service demand using combined forecasting approach

    NASA Astrophysics Data System (ADS)

    Zhou, Ling

    2017-08-01

    Forecasting facilitates cutting down operational and management costs while ensuring service level for a logistics service provider. Our case study here is to investigate how to forecast short-term logistic demand for a LTL carrier. Combined approach depends on several forecasting methods simultaneously, instead of a single method. It can offset the weakness of a forecasting method with the strength of another, which could improve the precision performance of prediction. Main issues of combined forecast modeling are how to select methods for combination, and how to find out weight coefficients among methods. The principles of method selection include that each method should apply to the problem of forecasting itself, also methods should differ in categorical feature as much as possible. Based on these principles, exponential smoothing, ARIMA and Neural Network are chosen to form the combined approach. Besides, least square technique is employed to settle the optimal weight coefficients among forecasting methods. Simulation results show the advantage of combined approach over the three single methods. The work done in the paper helps manager to select prediction method in practice.

  20. Operational strategies for dispatchable combined cycle plants, Part II

    SciTech Connect

    Nolan, J.P.; Landis, F.P.

    1996-11-01

    The Brush Cogeneration Facility is a dual-unit, combined cycle, cogeneration plant, operating in a dual cycling, automatically-dispatchable mode. Part I of this report described the contract, including automatic generation control (AGC) by Public Service Company of Colorado (PSCO), and the operation of Unit One. This part of the report covers the operation of Unit Two. Unit two is still in its operating infancy, but is showing that fuel efficiency and low emissions levels are not incompatible with cycling, load-following service. 1 fig.

  1. Quantum canonical ensemble: A projection operator approach

    NASA Astrophysics Data System (ADS)

    Magnus, Wim; Lemmens, Lucien; Brosens, Fons

    2017-09-01

    Knowing the exact number of particles N, and taking this knowledge into account, the quantum canonical ensemble imposes a constraint on the occupation number operators. The constraint particularly hampers the systematic calculation of the partition function and any relevant thermodynamic expectation value for arbitrary but fixed N. On the other hand, fixing only the average number of particles, one may remove the above constraint and simply factorize the traces in Fock space into traces over single-particle states. As is well known, that would be the strategy of the grand-canonical ensemble which, however, comes with an additional Lagrange multiplier to impose the average number of particles. The appearance of this multiplier can be avoided by invoking a projection operator that enables a constraint-free computation of the partition function and its derived quantities in the canonical ensemble, at the price of an angular or contour integration. Introduced in the recent past to handle various issues related to particle-number projected statistics, the projection operator approach proves beneficial to a wide variety of problems in condensed matter physics for which the canonical ensemble offers a natural and appropriate environment. In this light, we present a systematic treatment of the canonical ensemble that embeds the projection operator into the formalism of second quantization while explicitly fixing N, the very number of particles rather than the average. Being applicable to both bosonic and fermionic systems in arbitrary dimensions, transparent integral representations are provided for the partition function ZN and the Helmholtz free energy FN as well as for two- and four-point correlation functions. The chemical potential is not a Lagrange multiplier regulating the average particle number but can be extracted from FN+1 -FN, as illustrated for a two-dimensional fermion gas.

  2. Space Station overall management approach for operations

    NASA Technical Reports Server (NTRS)

    Paules, G.

    1986-01-01

    An Operations Management Concept developed by NASA for its Space Station Program is discussed. The operational goals, themes, and design principles established during program development are summarized. The major operations functions are described, including: space systems operations, user support operations, prelaunch/postlanding operations, logistics support operations, market research, and cost/financial management. Strategic, tactical, and execution levels of operational decision-making are defined.

  3. Space Station overall management approach for operations

    NASA Technical Reports Server (NTRS)

    Paules, G.

    1986-01-01

    An Operations Management Concept developed by NASA for its Space Station Program is discussed. The operational goals, themes, and design principles established during program development are summarized. The major operations functions are described, including: space systems operations, user support operations, prelaunch/postlanding operations, logistics support operations, market research, and cost/financial management. Strategic, tactical, and execution levels of operational decision-making are defined.

  4. Operational approach for oil spill monitoring

    NASA Astrophysics Data System (ADS)

    Franca, Gutemberg B.; Landau, Luiz; Tores, Audalio R., Jr.; Drumond, Jose A. L.; Fragoso, Mauricio R.; De Almeida, Ricardo C.; Cunha, Gerson G.; Pedroso, Enrico C.; Beisl, Carlos H.

    2003-05-01

    This paper presents the methodological approach of the oil spill monitoring system that is being put into operation by the National Petroleum Agency (NPA) in Brazil. The methodology is based on integrated analysis of multi-sensor data which includes satellites products, such as, GOES and AVHRR Sea Surface Temperature (SST), SeaWiFs chlorophyll concentration, QuikScat near sea surface wind field, GOES and AVHRR convective rain areas, and Synthetic Aperture RADAR (SAR) data from RADARSAT-1 satellite. The methodology is implemented by means of a system composed by four subsystems called, data reception (SAR, GOES, NOAA and QuikScat), Integrator, hydrodynamic model and database. The methodology was applied to the accidental oil spill caused by PETROBRAS oil rig P-36. A RADARSAT-1 image was acquired during accident period at 21:07 (GMT) on 22nd of March 2001 and used. The results are presented and discussed.

  5. Ramjet-Mode Operation in a Combined Cycle Engine Combustor

    NASA Astrophysics Data System (ADS)

    Kato, Kanenori; Kudo, Kenji; Murakami, Atsuo; Tani, Kouichiro; Kanda, Takeshi

    A rocket-ramjet combined-cycle engine was tested in ramjet-mode. The combustor model had two rockets in the combustor section. They were used as an igniter in this operation mode. In the preliminary tests, the downstream combustion ramjet-mode was demonstrated with a 1.4-degree of divergent duct condition. In this study, the upstream and downstream combustion ramjet-mode operations were applied to the combined cycle engine model with large angle of divergent duct condition. In the case of upstream combustion ramjet-mode, the combustion condition at the exit of the combustor showed high combustion efficiency.

  6. Adjoint operator approach in marginal separation theory

    NASA Astrophysics Data System (ADS)

    Braun, Stefan; Scheichl, Stefan; Kluwick, Alfred

    2013-10-01

    Thin airfoils are prone to localized flow separation at their leading edge if subjected to moderate angles of attack α. Although 'laminar separation bubbles' at first do not significantly alter the airfoil performance, they tend to 'burst' if a is increased further or perturbations acting upon the flow reach a certain intensity. This then leads either to global flow separation (stall) or triggers the laminar-turbulent transition process within the boundary layer flow. The present paper addresses the asymptotic analysis of the early stages of the latter phenomenon in the limit as the characteristic Reynolds number Re → ∞, commonly referred to as marginal separation theory (MST). A new approach based on the adjoint operator method is presented to derive the fundamental similarity laws of MST and to extend the analysis to higher order. Special emphasis is placed on the breakdown of the flow description, i.e. the formation of finite time singularities (a manifestation of the bursting process), and its resolution based on asymptotic reasoning. The computation of the spatio-temporal evolution of the flow in the subsequent triple deck stage is performed by means of a Chebyshev spectral method. The associated numerical treatment of fractional integrals characteristic of MST is based on barycentric Lagrange interpolation, which is described in detail.

  7. A systematic approach to upgrading operating procedures

    SciTech Connect

    Solne, B.J. III; Richardson, C.E. ); Corson, J.A. )

    1993-01-01

    Some utilities emphasize Operations Department procedure content details without an overall philosophy of operation. A methodology has been formulated to produce high-quality operating procedures by establishing a logical, hierarchical structure of procedure types and identifying procedure interfaces and development and implementation sequences and schedules.

  8. Local anesthesia for abdominoplasty, liposuction, and combined operations.

    PubMed

    Mottura, A A

    1993-01-01

    This article describes a procedure to perform abdominoplasty, liposuction, and combined operations under local anesthesia. With an anesthetic solution composed of 25 cc of 2% lidocaine, 25 cc of 0.5% bupivacaine, 1 cc of epinephrine or ornipresine, and 350 cc of saline solution, a satisfactory dilution with low concentration and lasting effects was obtained. After infiltration a large amount was lost in the incision, the dissection, and the resected dermofatty tissue. A small amount of anesthetic remained in the operated area to be metabolized by the liver. Low lidocaine levels were found in venous blood samples during surgery. This type of anesthesia is advised in minor, limited, and normal abdominoplasties in normal-sized patients, or major abdominoplasties in small patients. In liposuction procedures, it is possible to anesthetize the patient using the same procedure and operate in an equivalent area. As a high proportion of the infiltrated anesthesia was lost during the operation, a similar amount could be used to infiltrate and operate other areas so that an abdominoplasty might be combined with liposuction or mastoplasty. We have experience with 25 abdominoplasties and 21 liposuctions performed under local anesthesia. There were no complications related to local anesthesia and no one had unpleasant memories of intraoperative events.

  9. Combined operation of two ground transmitters for enhanced ionospheric heating

    NASA Technical Reports Server (NTRS)

    Lee, M. C.; Groves, K. M.; Liao, C. P.; Rivas, D. R.; Kuo, S. P.

    1988-01-01

    The combined operation of a high or medium frequency ground transmitter and a VLF transmitter for enhanced ionospheric heating is examined. The high or medium frequency transmitter operating in a pulsed mode produce short-scale density striations that can render the nonlinear mode conversion of the subsequently launched VLF waves into lower hybrid waves. Also if the VLF waves are intense enough, they can excite meter-scale density striations and lower hybrid waves via parametric instabilities. The expected ionospheric effects of the system are discussed.

  10. Operational Approach to Generalized Coherent States

    NASA Technical Reports Server (NTRS)

    DeMartino, Salvatore; DeSiena, Silvio

    1996-01-01

    Generalized coherent states for general potentials, constructed through a controlling mechanism, can also be obtained applying on a reference state suitable operators. An explicit example is supplied.

  11. A combination approach to treating fungal infections

    PubMed Central

    Shrestha, Sanjib K.; Fosso, Marina Y.; Garneau-Tsodikova, Sylvie

    2015-01-01

    Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strategy to fight resistant fungal isolates. Recently, amphiphilic tobramycin analogues, C12 and C14, were shown to display antifungal activities. Herein, the antifungal synergy of C12 and C14 with four azoles, fluconazole (FLC), itraconazole (ITC), posaconazole (POS), and voriconazole (VOR), was examined against seven Candida albicans strains. All tested strains were synergistically inhibited by C12 when combined with azoles, with the exception of C. albicans 64124 and MYA-2876 by FLC and VOR. Likewise, when combined with POS and ITC, C14 exhibited synergistic growth inhibition of all C. albicans strains, except C. albicans MYA-2876 by ITC. The combinations of FLC-C14 and VOR-C14 showed synergistic antifungal effect against three C. albicans and four C. albicans strains, respectively. Finally, synergism between C12/C14 and POS were confirmed by time-kill and disk diffusion assays. These results suggest the possibility of combining C12 or C14 with azoles to treat invasive fungal infections at lower administration doses or with a higher efficiency. PMID:26594050

  12. 14 CFR 121.661 - Initial approach altitude: Flag operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Initial approach altitude: Flag operations... § 121.661 Initial approach altitude: Flag operations. When making an initial approach to a radio navigation facility under IFR, no person may descend below the pertinent minimum altitude for...

  13. 14 CFR 121.661 - Initial approach altitude: Flag operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Initial approach altitude: Flag operations... § 121.661 Initial approach altitude: Flag operations. When making an initial approach to a radio navigation facility under IFR, no person may descend below the pertinent minimum altitude for...

  14. 14 CFR 121.661 - Initial approach altitude: Flag operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Initial approach altitude: Flag operations... § 121.661 Initial approach altitude: Flag operations. When making an initial approach to a radio navigation facility under IFR, no person may descend below the pertinent minimum altitude for...

  15. 14 CFR 121.661 - Initial approach altitude: Flag operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Initial approach altitude: Flag operations... § 121.661 Initial approach altitude: Flag operations. When making an initial approach to a radio navigation facility under IFR, no person may descend below the pertinent minimum altitude for...

  16. 14 CFR 121.661 - Initial approach altitude: Flag operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Initial approach altitude: Flag operations... § 121.661 Initial approach altitude: Flag operations. When making an initial approach to a radio navigation facility under IFR, no person may descend below the pertinent minimum altitude for...

  17. Combining Phonics: Approaches for Problem Readers.

    ERIC Educational Resources Information Center

    Gillis, M. K.

    1982-01-01

    A method of teaching phonics to primary grade disabled readers which combines analytic, synthetic, and linguistic methods is described. The method involves starting with sight words, starting phonics synthetically with consonants, teaching other consonants analytically, adapting linguistic methods for vowels, and encouraging the use of context.…

  18. Combining a Behavioral Approach with Reality Therapy

    ERIC Educational Resources Information Center

    Gronert, Richard R.

    1970-01-01

    Two comprehensive case studies present the careful use of a Time Out" approach to behavior modification with elementary school students. These sessions should be undertaken only under supervision of the school psychologist since a Time Out" can produce damaging psychological effects if used indiscriminately. (CJ)

  19. NASA operations: An agency wide approach to reduce cost

    NASA Technical Reports Server (NTRS)

    Squibb, Gael F.

    1996-01-01

    The NASA Space Operations Management Office (SOMO) is presented. The SOMO concept is based on continuing the distributed participation of the various NASA field centers and agencies, while employing consolidated management through a single lead center. The aim is to determine the duplicity and the overlap between the different agencies that independently developed their own operations management approaches in order to enable more cost effective mission operations by providing common services to the NASA programs. The space operations management will be performed in a distributed manner with a greater degree of contractor involvement than in the past. The changes, approaches and anticipated benefits of this approach to operations are discussed.

  20. An approach to operating system testing

    NASA Technical Reports Server (NTRS)

    Sum, R. N., Jr.; Campbell, R. H.; Kubitz, W. J.

    1984-01-01

    To ensure the reliability and performance of a new system, it must be verified or validated in some manner. Currently, testing is the only resonable technique available for doing this. Part of this testing process is the high level system test. System testing is considered with respect to operating systems and in particular UNIX. This consideration results in the development and presentation of a good method for performing the system test. The method includes derivations from the system specifications and ideas for management of the system testing project. Results of applying the method to the IBM System/9000 XENIX operating system test and the development of a UNIX test suite are presented.

  1. A Simplified Approach to Product Operator Formalism

    ERIC Educational Resources Information Center

    Spiese, Christopher E.

    2004-01-01

    The utilization of the simple and traditional vector model-based product operator formalism is highlighted. It is seen as a critical device in the area of nuclear magnetic resonance (NMR) spectrometry for a comprehensive analysis of spin coupling and quantum coherences.

  2. A Simplified Approach to Product Operator Formalism

    ERIC Educational Resources Information Center

    Spiese, Christopher E.

    2004-01-01

    The utilization of the simple and traditional vector model-based product operator formalism is highlighted. It is seen as a critical device in the area of nuclear magnetic resonance (NMR) spectrometry for a comprehensive analysis of spin coupling and quantum coherences.

  3. Recent Airpower Approaches to Counterinsurgency Operations

    DTIC Science & Technology

    2015-04-01

    around the world. As the nation continues to address security concerns in far flung corners of the earth, the USAF must posture itself to meet the...of fiscal constraints, it will become increasingly difficult to provide a balanced force structure that maintains capabilities for low intensity...COIN) operations around the world. As the nation continues to address security concerns in far flung corners of the earth, the USAF must posture

  4. Influence Operations: Redefining the Indirect Approach

    DTIC Science & Technology

    2011-06-01

    religious education. Reopened in 1959 after years of dormancy, Guzman subverted the university for use as a base to recruit and training of Shining Path...public and that its distribution is unlimited effective October 17, 2011. University Librarian Naval Postgraduate School http://www.nps.edu THIS PAGE...REDEFINING THE INDIRECT APPROACH Edward M. Lopacienski Major, United States Army B.A., University of Maryland, Baltimore County, 1996 William M

  5. The combined approach to intracranial aneurysm treatment.

    PubMed

    Alexander, Brian L; Riina, Howard A

    2009-12-01

    A consecutive series of patients with intracranial aneurysms in the practice of one neurovascular surgeon was retrospectively reviewed to illustrate that one physician can become proficient in microneurosurgery as well as endovascular surgery and achieve favorable outcomes in both disciplines. This supports one model of training for cerebrovascular surgeons that includes the complimentary practice of open microneurovascular surgery with endovascular surgery. The senior author (HAR) treated 351 patients with 413 aneurysms between July 2001 and March 2007. Of these, 172 patients (216 aneurysms) were treated with open microneurosurgical techniques and 179 patients (197 aneurysms) were treated using endovascular techniques. Complete obliteration was attained in 94.3% of clipped aneurysms, and 61.9% and 65.9% of coiled aneurysms immediately and after at least 6 months of follow-up, respectively. At latest evaluation, 93% of endovascular patients and 90% of microneurosurgical patients had good clinical outcomes (GOS, 4 or 5; mean follow-up, 23 months; combines ruptured and unruptured cohorts). Procedure-related mortality included 1 surgical patient and 2 endovascular patients. Because the fields of microvascular and endovascular surgeries are both technically complex, there has been concern that hybrid cerebrovascular surgeons cannot perform each technique with the skill necessary to achieve good outcomes. When compared to clipping and coiling reviews in the neurosurgical literature, we illustrate that one hybrid neurovascular surgeon is capable of attaining great facility in both techniques and that this type of physician will represent one practice model of cerebrovascular specialist in the future. This has potential implications for the training of hybrid cerebrovascular surgeons. Copyright 2009 Elsevier Inc. All rights reserved.

  6. A data mining approach to intelligence operations

    NASA Astrophysics Data System (ADS)

    Memon, Nasrullah; Hicks, David L.; Harkiolakis, Nicholas

    2008-03-01

    In this paper we examine the latest thinking, approaches and methodologies in use for finding the nuggets of information and subliminal (and perhaps intentionally hidden) patterns and associations that are critical to identify criminal activity and suspects to private and government security agencies. An emphasis in the paper is placed on Social Network Analysis and Investigative Data Mining, and the use of these technologies in the counterterrorism domain. Tools and techniques from both areas are described, along with the important tasks for which they can be used to assist with the investigation and analysis of terrorist organizations. The process of collecting data about these organizations is also considered along with the inherent difficulties that are involved.

  7. Hypnotherapy: A Combined Approach Using Psychotherapy and Behavior Modification.

    ERIC Educational Resources Information Center

    Goldberg, Bruce

    1987-01-01

    Discusses use of hypnosis in traditional psychoanalysis, compares use of hypnosis in behavior modification therapy versus psychoanalysis, and presents a hypno-behavioral model which combines both approaches using hypnosis as the medium. (Author/NB)

  8. Hypnotherapy: A Combined Approach Using Psychotherapy and Behavior Modification.

    ERIC Educational Resources Information Center

    Goldberg, Bruce

    1987-01-01

    Discusses use of hypnosis in traditional psychoanalysis, compares use of hypnosis in behavior modification therapy versus psychoanalysis, and presents a hypno-behavioral model which combines both approaches using hypnosis as the medium. (Author/NB)

  9. Combined monitoring, decision and control model for the human operator in a command and control desk

    NASA Technical Reports Server (NTRS)

    Muralidharan, R.; Baron, S.

    1978-01-01

    A report is given on the ongoing efforts to mode the human operator in the context of the task during the enroute/return phases in the ground based control of multiple flights of remotely piloted vehicles (RPV). The approach employed here uses models that have their analytical bases in control theory and in statistical estimation and decision theory. In particular, it draws heavily on the modes and the concepts of the optimal control model (OCM) of the human operator. The OCM is being extended into a combined monitoring, decision, and control model (DEMON) of the human operator by infusing decision theoretic notions that make it suitable for application to problems in which human control actions are infrequent and in which monitoring and decision-making are the operator's main activities. Some results obtained with a specialized version of DEMON for the RPV control problem are included.

  10. 15. LOOKING DUE EAST FROM OPERATOR'S HOUSE, WITH TRAIN APPROACHING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. LOOKING DUE EAST FROM OPERATOR'S HOUSE, WITH TRAIN APPROACHING BRIDGE. - Chicago, Milwaukee & St. Paul Railway, Bridge No. Z-6, Spanning North Branch of Chicago River, South of Cortland Street, Chicago, Cook County, IL

  11. [Lateral position one-stage combined posteroanterior approaches for the treatment of lumbosacral tuberculous spondylitis].

    PubMed

    Bai, Jian-Qiang; Xia, Qun; Hu, Yong-Cheng; Xu, Bao-Shan; Ji, Ning; Miao, Jun; Liu, Yan-Cheng

    2011-08-23

    To investigate the feasibility of a one-stage combined posteroanterior approaches for the treatment of lumbosacral tuberculous spondylitis with the patients lying in a lateral position. A retrospective review was conducted for 15 patients with lumbosacral tuberculosis undergoing one-stage combined posteroanterior approaches for radical lesion resection and reconstruction. All patients were observed and evaluated by clinical and imaging studies. Operative posture:11 cases for right side and 4 cases for left side. The mean operative duration was 280 min (range: 230 - 380 min) and the mean estimated volume of blood loss 1720 ml (range: 1100 - 3000 ml). Imaging results: No recurrence of tuberculose focus was found until the last follow-up. Upon image reviewing, it showed no loosening or displacement except for two cases of slightly collapsed titanium mesh. Preoperative and postoperative changes in the degree of lumbar lordosis were statistically significant [(20 ± 5)° vs (31 ± 5)°, P < 0.05]. The Kirkaldy-Willis classification rating yielded satisfactory results for 13 cases. The patients with lumbosacral tuberculosis undergoing one-stage combined posteroanterior approaches may achieve radical lesion resection, posteroanterior collaboration and reconstruction. It avoids a 2-stage operation, eliminates the need of changing a patient's body position with secondary sterilization and shortens the operative duration. Lumbosacral surgery for tuberculosis combines the respective advantages of anterior, posterior and combined posteroanterior approaches and yet makes up for their deficiencies.

  12. Shaping nondiffracting beams with a differential operator approach

    NASA Astrophysics Data System (ADS)

    Lopez-Mago, Dorilian; Gutiérrez-Vega, Julio C.

    2016-09-01

    The commutation between the Helmholtz equation and the derivative operator allows us to generate novel nondiffracting beams. We apply a general differential operator to Bessel beams and study the resulting phase structure and orbital angular momentum (OAM). We find the parameters that preserve the OAM of the seed beam and show how to produce and control shape preserving vortex arrays. In analogy to the Poincaré sphere, our approach is used to develop an operator sphere connecting higher-order Bessel beams.

  13. A Computational Approach for Identifying Synergistic Drug Combinations

    PubMed Central

    Gayvert, Kaitlyn M.; Aly, Omar; Bosenberg, Marcus W.; Stern, David F.; Elemento, Olivier

    2017-01-01

    A promising alternative to address the problem of acquired drug resistance is to rely on combination therapies. Identification of the right combinations is often accomplished through trial and error, a labor and resource intensive process whose scale quickly escalates as more drugs can be combined. To address this problem, we present a broad computational approach for predicting synergistic combinations using easily obtainable single drug efficacy, no detailed mechanistic understanding of drug function, and limited drug combination testing. When applied to mutant BRAF melanoma, we found that our approach exhibited significant predictive power. Additionally, we validated previously untested synergy predictions involving anticancer molecules. As additional large combinatorial screens become available, this methodology could prove to be impactful for identification of drug synergy in context of other types of cancers. PMID:28085880

  14. U.S. Southwest Border Security: An Operational Approach

    DTIC Science & Technology

    2012-06-08

    environmental frame). 2. Problem Frame. 3. Operational Approach. Army Lieutenant Colonel (LTC) Celestino Perez , an Assistant Professor at the U.S...pragmatic approach. In an effort to amplify the categories mentioned above, LTC Perez recommends using key questions as a guide. Two of his questions...

  15. Issues and approaches in control for autonomous reactor operation

    SciTech Connect

    Vilim, R. B.; Khalil, H. S.; Wei, T. Y. C.

    2000-07-20

    A capability for autonomous and passively safe operation is one of the goals of the NERI funded development of Generation IV nuclear plants. An approach is described for evaluating the effect of increasing autonomy on safety margins and load behavior and for examining issues that arise with increasing autonomy and their potential impact on performance. The method provides a formal approach to the process of exploiting the innate self-regulating property of a reactor to make it less dependent on operator action and less vulnerable to automatic control system fault and/or operator error. Some preliminary results are given.

  16. Autonomous onboard crew operations: A review and developmental approach

    NASA Technical Reports Server (NTRS)

    Rogers, J. G.

    1982-01-01

    A review of the literature generated by an intercenter mission approach and consolidation team and their contractors was performed to obtain background information on the development of autonomous operations concepts for future space shuttle and space platform missions. The Boeing 757/767 flight management system was examined to determine the relevance for transfer of the developmental approach and technology to the performance of the crew operations function. In specific, the engine indications and crew alerting system was studied to determine the relevance of this display for the performance of crew operations onboard the vehicle. It was concluded that the developmental approach and technology utilized in the aeronautics industry would be appropriate for development of an autonomous operations concept for the space platform.

  17. Autonomous onboard crew operations: A review and developmental approach

    NASA Technical Reports Server (NTRS)

    Rogers, J. G.

    1982-01-01

    A review of the literature generated by an intercenter mission approach and consolidation team and their contractors was performed to obtain background information on the development of autonomous operations concepts for future space shuttle and space platform missions. The Boeing 757/767 flight management system was examined to determine the relevance for transfer of the developmental approach and technology to the performance of the crew operations function. In specific, the engine indications and crew alerting system was studied to determine the relevance of this display for the performance of crew operations onboard the vehicle. It was concluded that the developmental approach and technology utilized in the aeronautics industry would be appropriate for development of an autonomous operations concept for the space platform.

  18. Combined robotic transanal total mesorectal excision (R-taTME) and single-site plus one-port (R-SSPO) technique for ultra-low rectal surgery-initial experience with a new operation approach.

    PubMed

    Kuo, Li-Jen; Ngu, James Chi-Yong; Tong, Yiu-Shun; Chen, Chia-Che

    2017-02-01

    Robot-assisted rectal surgery is gaining popularity, and robotic single-site surgery is also being explored clinically. We report our initial experience with robotic transanal total mesorectal excision (R-taTME) and radical proctectomy using the robotic single-site plus one-port (R-SSPO) technique for low rectal surgery. Between July 2015 and March 2016, 15 consecutive patients with ultra-low rectal lesions underwent R-taTME followed by radical proctectomy using the R-SSPO technique by a single surgeon. The clinical and pathological results were retrospectively analyzed. The median operative time was 473 (range, 335-569) min, and the estimated blood loss was 33 (range, 30-50) mL. The median number of lymph nodes harvested was 12 (range, 8-18). The median distal resection margin was 1.4 (range, 0.4-3.5) cm, and all patients had clear circumferential resection margins. We encountered a left ureteric transection intraoperatively in one patient, and another patient required reoperation for postoperative adhesive intestinal obstruction. There was no 30-day mortality. R-taTME followed by radical proctectomy using the R-SSPO technique for patients with low rectal lesions is technically feasible and safe without compromising oncologic outcomes. However, there were considerable limitations and a steep learning curve using current robotic technology.

  19. A systematic approach: optimization of healthcare operations with knowledge management.

    PubMed

    Wickramasinghe, Nilmini; Bali, Rajeev K; Gibbons, M Chris; Choi, J H James; Schaffer, Jonathan L

    2009-01-01

    Effective decision making is vital in all healthcare activities. While this decision making is typically complex and unstructured, it requires the decision maker to gather multispectral data and information in order to make an effective choice when faced with numerous options. Unstructured decision making in dynamic and complex environments is challenging and in almost every situation the decision maker is undoubtedly faced with information inferiority. The need for germane knowledge, pertinent information and relevant data are critical and hence the value of harnessing knowledge and embracing the tools, techniques, technologies and tactics of knowledge management are essential to ensuring efficiency and efficacy in the decision making process. The systematic approach and application of knowledge management (KM) principles and tools can provide the necessary foundation for improving the decision making processes in healthcare. A combination of Boyd's OODA Loop (Observe, Orient, Decide, Act) and the Intelligence Continuum provide an integrated, systematic and dynamic model for ensuring that the healthcare decision maker is always provided with the appropriate and necessary knowledge elements that will help to ensure that healthcare decision making process outcomes are optimized for maximal patient benefit. The example of orthopaedic operating room processes will illustrate the application of the integrated model to support effective decision making in the clinical environment.

  20. Promoting a Combination Approach to Paediatric HIV Psychosocial Support

    PubMed Central

    Amzel, Anouk; Toska, Elona; Lovich, Ronnie; Widyono, Monique; Patel, Tejal; Foti, Carrie; Dziuban, Eric J.; Phelps, B. Ryan; Sugandhi, Nandita; Mark, Daniella; Altschuler, Jenny

    2015-01-01

    , there is still limited evidence demonstrating which interventions have positive effects on the well being of HIV-infected children. Interventions that improve the psychosocial well being of children living with HIV must be replicable in resource-limited settings, avoiding dependence on specialized staff for implementation. This paper advocates for combination approaches that strengthen the capacity of service providers, expand the availability of age appropriate and family-centred support and equip schools to be more protective and supportive of children living with HIV. The coordination of care with other community-based interventions is also needed to foster more supportive and less stigmatizing environments. To ensure effective, feasible, and scalable interventions, improving the evidence base to document improved outcomes and longer term impact as well as implementation of operational studies to document delivery approaches are needed. PMID:24361624

  1. Promoting a combination approach to paediatric HIV psychosocial support.

    PubMed

    Amzel, Anouk; Toska, Elona; Lovich, Ronnie; Widyono, Monique; Patel, Tejal; Foti, Carrie; Dziuban, Eric J; Phelps, B Ryan; Sugandhi, Nandita; Mark, Daniella; Altschuler, Jenny

    2013-11-01

    is still limited evidence demonstrating which interventions have positive effects on the well being of HIV-infected children. Interventions that improve the psychosocial well being of children living with HIV must be replicable in resource-limited settings, avoiding dependence on specialized staff for implementation.This paper advocates for combination approaches that strengthen the capacity of service providers, expand the availability of age appropriate and family-centred support and equip schools to be more protective and supportive of children living with HIV. The coordination of care with other community-based interventions is also needed to foster more supportive and less stigmatizing environments. To ensure effective, feasible, and scalable interventions, improving the evidence base to document improved outcomes and longer term impact as well as implementation of operational studies to document delivery approaches are needed.

  2. Concept of Operations for Interval Management Arrivals and Approach

    NASA Technical Reports Server (NTRS)

    Hicok, Daniel S.; Barmore, Bryan E.

    2016-01-01

    This paper presents the concept of operations for interval management operations to be deployed in the US National Airspace System (NAS) by the Federal Aviation Administration (FAA) Interval Management Program. The arrivals and approach operations are explored in detail including the primary operation and variations. The use of interval management operations is described that begin in en route airspace and continue to a termination point inside the arrival terminal area in the highly automated terminal environment that includes other arrival management tools such as arrival metering, Ground-based Interval Management - Spacing (GIM-S), and Terminal Sequencing and Spacing (TSAS). The roles of Air Traffic and Pilots and the ground automation tools that are used by Air Traffic Controllers to enable the operations are explored.

  3. Protein Engineering by Combined Computational and In Vitro Evolution Approaches.

    PubMed

    Rosenfeld, Lior; Heyne, Michael; Shifman, Julia M; Papo, Niv

    2016-05-01

    Two alternative strategies are commonly used to study protein-protein interactions (PPIs) and to engineer protein-based inhibitors. In one approach, binders are selected experimentally from combinatorial libraries of protein mutants that are displayed on a cell surface. In the other approach, computational modeling is used to explore an astronomically large number of protein sequences to select a small number of sequences for experimental testing. While both approaches have some limitations, their combination produces superior results in various protein engineering applications. Such applications include the design of novel binders and inhibitors, the enhancement of affinity and specificity, and the mapping of binding epitopes. The combination of these approaches also aids in the understanding of the specificity profiles of various PPIs.

  4. Combining formal and functional approaches to topic structure.

    PubMed

    Zellers, Margaret; Post, Brechtje

    2012-03-01

    Fragmentation between formal and functional approaches to prosodic variation is an ongoing problem in linguistic research. In particular, the frameworks of the Phonetics of Talk-in-Interaction (PTI) and Empirical Phonology (EP) take very different theoretical and methodological approaches to this kind of variation. We argue that it is fruitful to adopt the insights of both PTI's qualitative analysis and EP's quantitative analysis and combine them into a multiple-methods approach. One realm in which it is possible to combine these frameworks is in the analysis of discourse topic structure and the prosodic cues relevant to it. By combining a quantitative and a qualitative approach to discourse topic structure, it is possible to give a better account of the observed variation in prosody, for example in the case of fundamental frequency (F0) peak timing, which can be explained in terms of pitch accent distribution over different topic structure categories. Similarly, local and global patterns in speech rate variation can be better explained and motivated by adopting insights from both PTI and EP in the study of topic structure. Combining PTI and EP can provide better accounts of speech data as well as opening up new avenues of investigation which would not have been possible in either approach alone.

  5. A combined geometric approach for solving the Navier-Stokes equations on dynamic grids

    NASA Technical Reports Server (NTRS)

    Slater, John W.

    1995-01-01

    A combined geometric approach for solving the Navier-Stokes equations is presented for the analysis of planar, unsteady flow about mechanisms with components in moderate relative motion. The approach emphasizes the relationships between the geometry model, grid, and flow model for the benefit of the total dynamics problem. One application is the analysis of the restart operation of a variable-geometry, high-speed inlet.

  6. Synthesized voice approach callouts for air transport operations

    NASA Technical Reports Server (NTRS)

    Simpson, C. A.

    1980-01-01

    A flight simulation experiment was performed to determine the effectiveness of synthesized voice approach callouts for air transport operations. Flight deck data was first collected on scheduled air carrier operations to describe existing pilot-not-flying callout procedures in the flight context and to document the types and amounts of other auditory cockpit information during different types of air carrier operations. A flight simulation scenario for a wide-body jet transport airline training simulator was developed in collaboration with a major U.S. air carrier and flown by three-man crews of qualified line pilots as part of their normally scheduled recurrent training. Each crew flew half their approaches using the experimental synthesized voice approach callout system (SYNCALL) and the other half using the company pilot-not-flying approach callout procedures (PNF). Airspeed and sink rate performance was better with the SYNCALL system than with the PNF system for non-precision approaches. For the one-engine approach, for which SYNCALL made inappropriate deviation callouts, airspeed performance was worse with SYNCALL than with PNF. Reliability of normal altitude approach callouts was comparable for PNF on the line and in the simulator and for SYNCALL in the simulator.

  7. Operative links: the importance of combining perspectives in municipal strategies aimed at children's and adolescents' health.

    PubMed

    Wistoft, Karen; Højlund, Holger

    2012-06-01

    The subject of investigation is the ways in which the Danish municipalities organize prevention and health-promotion efforts for children and adolescents. The aim is to examine how health managerial ideas have been combined with health professional ideals concerning different health educational approaches. Mixed qualitative design: survey based on telephone interviews with health managers (n=72), personal and focus group interviews with health professionals (n=84) and pupils (n=108) from 18 school classes, and comparative case studies in five selected municipalities of various size and geographical location. The theoretical framework has three positions combining a public management perspective with a pedagogical perspective on health promotion. The municipalities give high priority to prevention and health promotion directed toward children and adolescents and face a number of challenges at the management, collaboration, and knowledge levels. Missing links is one of the main points. Health managers and health professionals are preoccupied with some educational consequences of the health interventions, but they do not focus to the same extent on explicit health educational goals, learning content, or value clarification. Health pedagogy is often a matter of retrospective rationalization rather than the starting point of planning. Health and risk behaviour approaches override health educational approaches. Operational links between health education, health professionalism, and management strategies pose the foremost challenge. Operational links indicates cooperative levels that facilitate a creative and innovative effort across traditional professional boundaries. It is proposed that such links are supported by network structures, shared semantics, and situated pedagogical means of intervention.

  8. Shaping Bessel beams with a generalized differential operator approach

    NASA Astrophysics Data System (ADS)

    Lopez-Mago, Dorilian; Gutiérrez-Vega, Julio C.

    2016-09-01

    We apply a differential creation operator to an integer order Bessel beam in order to generate novel nondiffracting structures. The resulting phase structure and orbital angular momentum are discussed in detail. We find the parameters that preserve the orbital angular momentum of the seed beam and show how to produce and control shape preserving vortex arrays. In analogy to the Poincaré sphere, our approach is used to develop an operator sphere connecting higher-order Bessel beams.

  9. Statistical Approach to the Operational Testing of Space Fence

    DTIC Science & Technology

    2015-07-01

    size of satellite tracks needed to estimate metric accuracy for individual TEARR parameters, which we calculate via chi - square hypothesis tests on...decisions. Index Terms— Analysis of variance, Operational testing , Least squares methods, Phased array radar, Satellite tracking, SATCAT, Space...I N S T I T U T E F O R D E F E N S E A N A L Y S E S Statistical Approach to the Operational Testing of Space Fence Daniel L. Pechkis Nelson S

  10. Risk-based approach to analyzing operating events

    SciTech Connect

    Marchese, A.R.; Neogy, P.

    1996-02-01

    Existing programs for the analysis of operating events at the Department of Energy (DOE) facilities do not determine risk measures for the events. An approach for the risk based analysis of operating events has been developed, and applied to two events. The approach utilizes the data now being collected in existing data programs and determines risk measures for the events which are not currently determined. Such risk measures allow risk appropriate responses to be made to events, and provide a means for comparing the safety significance of dissimilar events at different facilities.

  11. Combined AIE/EBE/GMRES approach to incompressible flows

    NASA Astrophysics Data System (ADS)

    Liou, J.; Tezduyar, T. E.

    Adaptive implicit-explicit (AIE), grouped element-by-element (GEBE), and generalized minimum residuals (GMRES) solution techniques for incompressible flows are combined. In this approach, the GEBE and GMRES iteration methods are employed to solve the equation systems resulting from the implicitly treated elements, and therefore no direct solution effort is involved. The benchmarking results demonstrate that this approach can substantially reduce the CPU time and memory requirements in large-scale flow problems. Although the description of the concepts and the numerical demonstration are based on the incompressible flows, the approach presented here is applicable to larger class of problems in computational mechanics.

  12. Spaceliner Class Operability Gains Via Combined Airbreathing/ Rocket Propulsion: Summarizing an Operational Assessment of Highly Reusable Space Transports

    NASA Technical Reports Server (NTRS)

    Nix, Michael B.; Escher, William J. d.

    1999-01-01

    and analysis tool development for advanced space transportation systems, followed by end-to-end system concept definitions and trade analyses, specific system concept definition and analysis, specific key technology and topic analysis, system, operational and economics model development, analysis, and integrated assessments. The HRST Integration Task Force (HITF) was formed to synthesize study results in several specific topic areas and support the development of conclusions from the study: Systems Concepts Definitions, Technology Assessment, Operations Assessment, and Cost Assessment. This paper summarizes the work of the Operations Assessment Team: the six approaches used, the analytical tools and methodologies developed and employed, the issues and concerns, and the results of the assessment. The approaches were deliberately varied in measures of merit and procedure to compensate for the uncertainty inherent in operations data in this early phase of concept exploration. In general, rocket based combined cycle (RBCC) concepts appear to have significantly greater potential than all-rocket concepts for reducing operations costs.

  13. Spaceliner Class Operability Gains Via Combined Airbreathing/ Rocket Propulsion: Summarizing an Operational Assessment of Highly Reusable Space Transports

    NASA Technical Reports Server (NTRS)

    Nix, Michael B.; Escher, William J. d.

    1999-01-01

    and analysis tool development for advanced space transportation systems, followed by end-to-end system concept definitions and trade analyses, specific system concept definition and analysis, specific key technology and topic analysis, system, operational and economics model development, analysis, and integrated assessments. The HRST Integration Task Force (HITF) was formed to synthesize study results in several specific topic areas and support the development of conclusions from the study: Systems Concepts Definitions, Technology Assessment, Operations Assessment, and Cost Assessment. This paper summarizes the work of the Operations Assessment Team: the six approaches used, the analytical tools and methodologies developed and employed, the issues and concerns, and the results of the assessment. The approaches were deliberately varied in measures of merit and procedure to compensate for the uncertainty inherent in operations data in this early phase of concept exploration. In general, rocket based combined cycle (RBCC) concepts appear to have significantly greater potential than all-rocket concepts for reducing operations costs.

  14. Combination and Boundary Detection Approaches on Chinese Indexing.

    ERIC Educational Resources Information Center

    Yang, Christopher C.; Luk, Johnny W. K.; Yung, Stanley K.; Yen, Jerome

    2000-01-01

    Discussion of information retrieval and automatic indexing in digital libraries focuses on Chinese indexing and cross-lingual information retrieval. Investigates the combination and boundary detection approaches based on mutual information for word segmentation, using lexical and statistical information. Reports results of experiments that…

  15. Combination and Boundary Detection Approaches on Chinese Indexing.

    ERIC Educational Resources Information Center

    Yang, Christopher C.; Luk, Johnny W. K.; Yung, Stanley K.; Yen, Jerome

    2000-01-01

    Discussion of information retrieval and automatic indexing in digital libraries focuses on Chinese indexing and cross-lingual information retrieval. Investigates the combination and boundary detection approaches based on mutual information for word segmentation, using lexical and statistical information. Reports results of experiments that…

  16. Combining Approaches for the Analysis of Collaborative Mathematics Learning

    ERIC Educational Resources Information Center

    Tatsis, Konstantinos; Dekker, Rijkje

    2010-01-01

    An episode of two students working collaboratively on a mathematical problem is analysed combining two approaches, namely the process model for mathematical level raising and role theory. The process model stresses the importance of key and regulating activities, while role theory deals with the inter- and intrapersonal concerns of the…

  17. Combining Approaches for the Analysis of Collaborative Mathematics Learning

    ERIC Educational Resources Information Center

    Tatsis, Konstantinos; Dekker, Rijkje

    2010-01-01

    An episode of two students working collaboratively on a mathematical problem is analysed combining two approaches, namely the process model for mathematical level raising and role theory. The process model stresses the importance of key and regulating activities, while role theory deals with the inter- and intrapersonal concerns of the…

  18. Automatic Combination of Operators in a Genetic Algorithm to Solve the Traveling Salesman Problem

    PubMed Central

    2015-01-01

    Genetic algorithms are powerful search methods inspired by Darwinian evolution. To date, they have been applied to the solution of many optimization problems because of the easy use of their properties and their robustness in finding good solutions to difficult problems. The good operation of genetic algorithms is due in part to its two main variation operators, namely, crossover and mutation operators. Typically, in the literature, we find the use of a single crossover and mutation operator. However, there are studies that have shown that using multi-operators produces synergy and that the operators are mutually complementary. Using multi-operators is not a simple task because which operators to use and how to combine them must be determined, which in itself is an optimization problem. In this paper, it is proposed that the task of exploring the different combinations of the crossover and mutation operators can be carried out by evolutionary computing. The crossover and mutation operators used are those typically used for solving the traveling salesman problem. The process of searching for good combinations was effective, yielding appropriate and synergic combinations of the crossover and mutation operators. The numerical results show that the use of the combination of operators obtained by evolutionary computing is better than the use of a single operator and the use of multi-operators combined in the standard way. The results were also better than those of the last operators reported in the literature. PMID:26367182

  19. Fully endoscopic combined transsphenoidal and supraorbital keyhole approach for parasellar lesions.

    PubMed

    Nagata, Yuichi; Watanabe, Tadashi; Nagatani, Tetsuya; Takeuchi, Kazuhito; Chu, Jonsu; Wakabayashi, Toshihiko

    2017-04-28

    OBJECTIVE Parasellar tumors that extend far laterally beyond the internal carotid artery or that are fibrous and adhere firmly to critical structures are difficult to remove totally via the endoscopic transsphenoidal approach alone. In such cases, a combined transsphenoidal-transcranial approach is effective to achieve maximal resection in a single stage. In this paper, a new minimally invasive surgical technique for complicated parasellar lesions, a fully endoscopic combined transsphenoidal-supraorbital keyhole approach, is presented. METHODS A retrospective review of patients who had been treated via a fully endoscopic combined transsphenoidal-supraorbital keyhole approach for complicated parasellar lesions was performed. The data for resection rate, perioperative mortality and morbidity, and postoperative outcomes were analyzed. RESULTS A total of 12 fully endoscopic combined transsphenoidal-supraorbital keyhole approaches were performed from March 2013 to February 2016; 10 were for pituitary adenomas and 2 were for craniopharyngiomas. Gross-total resection or near-total resection was achieved in 7 of 12 cases. Among the 11 patients who had presented with preoperative visual disturbances, 7 had visual improvement. However, 1 patient showed deterioration in visual function. No patient experienced postoperative hemorrhage, needed additional surgical treatment, or had postoperative CSF leakage. CONCLUSIONS In the combined transsphenoidal and transcranial approach, safe and effective cooperative manipulation with 2 surgical corridors can be performed for complicated parasellar lesions. The goal of this procedure is not to achieve gross-total resection, but to achieve safe resection. Moreover, this new surgical approach offers neurosurgeons a simpler operative field with less invasiveness than the conventional microscopic combined approach. The fully endoscopic combined endonasal-supraorbital keyhole approach is an efficacious procedure for complicated parasellar

  20. Combined laparoscopic and open extraperitoneal approach to scrotal hernias.

    PubMed

    Ferzli, G S; Rim, S; Edwards, E D

    2013-04-01

    Laparoscopic repair of scrotal hernias is often a difficult endeavor to successfully complete. The longstanding nature of these hernias often results in significant adhesions and anatomic distortion of the inguinal floor. These two issues make reduction of the hernia arduous and subsequent reinforcement of the parietal sac difficult. We have previously described techniques to increase the chances of success when attempting laparoscopic repair of scrotal hernias. Here, we describe some of those techniques as well as a combined laparoscopic and open approach to achieve a robust preperitoneal repair of incarcerated scrotal hernias when the usual totally extraperitoneal approach does not work. We performed a retrospective review of 1890 TEP hernia repairs we performed from 1990 to 2010. Rate of conversion to an open approach or a combined laparoscopic and open approach was examined. Incidence of complications or recurrences was assessed over a 12-month follow-up period. Among the 1890 TEP repairs, 94 large scrotal hernias were identified. Of these, nine cases (9.5 %) required conversion to an open procedure due to an incarcerated and indurated omentum. Three were completed with a conventional open preperitoneal whereas six patients (6.4 %) underwent repair with the combined approach. In this group, no recurrences or complications were found over a 12-month period. In cases where a large scrotal hernia may be difficult or dangerous to reduce laparoscopically, immediate conversion to an open repair may not be necessary. A combined laparoscopic and open approach can greatly assist in the visualization and dissection of the preperitoneal space, thereby facilitating reduction of the hernia and placement of the mesh.

  1. An agent-oriented approach to automated mission operations

    NASA Technical Reports Server (NTRS)

    Truszkowski, Walt; Odubiyi, Jide

    1994-01-01

    As we plan for the next generation of Mission Operations Control Center (MOCC) systems, there are many opportunities for the increased utilization of innovative knowledge-based technologies. The innovative technology discussed is an advanced use of agent-oriented approaches to the automation of mission operations. The paper presents an overview of this technology and discusses applied operational scenarios currently being investigated and prototyped. A major focus of the current work is the development of a simple user mechanism that would empower operations staff members to create, in real time, software agents to assist them in common, labor intensive operations tasks. These operational tasks would include: handling routine data and information management functions; amplifying the capabilities of a spacecraft analyst/operator to rapidly identify, analyze, and correct spacecraft anomalies by correlating complex data/information sets and filtering error messages; improving routine monitoring and trend analysis by detecting common failure signatures; and serving as a sentinel for spacecraft changes during critical maneuvers enhancing the system's capabilities to support nonroutine operational conditions with minimum additional staff. An agent-based testbed is under development. This testbed will allow us to: (1) more clearly understand the intricacies of applying agent-based technology in support of the advanced automation of mission operations and (2) access the full set of benefits that can be realized by the proper application of agent-oriented technology in a mission operations environment. The testbed under development addresses some of the data management and report generation functions for the Explorer Platform (EP)/Extreme UltraViolet Explorer (EUVE) Flight Operations Team (FOT). We present an overview of agent-oriented technology and a detailed report on the operation's concept for the testbed.

  2. 76 FR 50767 - Southern Nuclear Operating Co., et al.; Combined Licenses for Vogtle Electric Generating Plant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... COMMISSION Southern Nuclear Operating Co., et al.; Combined Licenses for Vogtle Electric Generating Plant... approval to construct and operate new nuclear power generation facilities at the Vogtle Electric Generating... (10 CFR) part 52 combined licenses (COLs), seeking approval to construct and operate new nuclear power...

  3. A Spreadsheet-Based Approach for Operations Research Teaching

    ERIC Educational Resources Information Center

    Munisamy, Susila

    2009-01-01

    This paper considers the use of spreadsheet for introducing students to a variety of quantitative models covered in an introductory Operations Research (OR) course at the University of Malaya, Malaysia. This approach allows students to develop skills in modeling as they learn to apply the various quantitative models in a spreadsheet. Indeed,…

  4. Planning and Assessing Stability Operations: A Proposed VFT Approach

    DTIC Science & Technology

    2007-05-22

    Name of Principal Author and all other author(s): Gerald D. Fensterer , Capt, USAF; Gary W. Kinney, Maj, USAF; Richard F. Deckro, DBA Author Request...Operations: A Proposed VFT Approach Capt Gerald Fensterer AFIT/GOR/ENS/07M Advisor: Maj. Gary Kinney Reader: Dr. Richard Deckro 22 May 2007 3

  5. An innovative approach to capability-based emergency operations planning.

    PubMed

    Keim, Mark E

    2013-01-01

    This paper describes the innovative use information technology for assisting disaster planners with an easily-accessible method for writing and improving evidence-based emergency operations plans. This process is used to identify all key objectives of the emergency response according to capabilities of the institution, community or society. The approach then uses a standardized, objective-based format, along with a consensus-based method for drafting capability-based operational-level plans. This information is then integrated within a relational database to allow for ease of access and enhanced functionality to search, sort and filter and emergency operations plan according to user need and technological capacity. This integrated approach is offered as an effective option for integrating best practices of planning with the efficiency, scalability and flexibility of modern information and communication technology.

  6. An innovative approach to capability-based emergency operations planning

    PubMed Central

    Keim, Mark E

    2013-01-01

    This paper describes the innovative use information technology for assisting disaster planners with an easily-accessible method for writing and improving evidence-based emergency operations plans. This process is used to identify all key objectives of the emergency response according to capabilities of the institution, community or society. The approach then uses a standardized, objective-based format, along with a consensus-based method for drafting capability-based operational-level plans. This information is then integrated within a relational database to allow for ease of access and enhanced functionality to search, sort and filter and emergency operations plan according to user need and technological capacity. This integrated approach is offered as an effective option for integrating best practices of planning with the efficiency, scalability and flexibility of modern information and communication technology. PMID:28228987

  7. Combined approach for experimental Oto-neurosurgical procedures.

    PubMed

    Macías-Reyes, Héctor; Ramos-Zúñiga, Rodrigo; Garcia-Estrada, Joaquín; Jáuregui-Huerta, Fernando; Hidalgo-Mariscal, Maria Leticia

    2012-01-01

    Experimental procedures will continue to be a key element while going through the learning curve in the use of the endoscope and minimally invasive procedures. We describe the technical procedure of an experimental approach to middle ear in New Zealand rabbits through external auditory canal and its relevance as an ideal model to study graft materials and serve as a training tool for potential applications in otoneurology. A group of 28 adult New Zealand rabbits were subjected to an experimental myringoplasty, combining the transmeatal and retroauricular approach with endoscopic assistance and microsurgical technique. The different anatomical steps and systematization of the complete experimental procedure are described. An experimental approach to middle ear live model and basic anatomic description was successfully used, standardizing the ideal technique. The eardrum could regenerate with no complications and with functional preservation in all the myringoplasty cases. This strategy involves a safe combined approach to the tympanic membrane and others neurosurgical as transcochlear and translaberyntic approaches and is useful as a test of other experimental procedures to evaluate biomaterials to repair the eardrum currently studied. This experimental myringoplasty model also facilitates functional tests such as impedanciometry and the endoscopic follow-up of the whole process. The method described to perform an experimental myringoplasty (type I tympanoplasty) in a New Zealand rabbit is an option to be used as a basic model to study the behavior of the graft in the tympanic membrane. Also, basic concepts for the use of combined instrumentation are established in the treatment of eardrum lesions, as a refinement of the technical training application in microsurgery and assisted endoscopy in the transcochlear and translaberintic approaches and otoneurology areas.

  8. Combined approach for experimental Oto-neurosurgical procedures

    PubMed Central

    Macías-Reyes, Héctor; Ramos-Zúñiga, Rodrigo; Garcia-Estrada, Joaquín; Jáuregui-Huerta, Fernando; Hidalgo-Mariscal, Maria Leticia

    2012-01-01

    Background: Experimental procedures will continue to be a key element while going through the learning curve in the use of the endoscope and minimally invasive procedures. We describe the technical procedure of an experimental approach to middle ear in New Zealand rabbits through external auditory canal and its relevance as an ideal model to study graft materials and serve as a training tool for potential applications in otoneurology. Methods: A group of 28 adult New Zealand rabbits were subjected to an experimental myringoplasty, combining the transmeatal and retroauricular approach with endoscopic assistance and microsurgical technique. The different anatomical steps and systematization of the complete experimental procedure are described. Results: An experimental approach to middle ear live model and basic anatomic description was successfully used, standardizing the ideal technique. The eardrum could regenerate with no complications and with functional preservation in all the myringoplasty cases. This strategy involves a safe combined approach to the tympanic membrane and others neurosurgical as transcochlear and translaberyntic approaches and is useful as a test of other experimental procedures to evaluate biomaterials to repair the eardrum currently studied. This experimental myringoplasty model also facilitates functional tests such as impedanciometry and the endoscopic follow-up of the whole process. Conclusions: The method described to perform an experimental myringoplasty (type I tympanoplasty) in a New Zealand rabbit is an option to be used as a basic model to study the behavior of the graft in the tympanic membrane. Also, basic concepts for the use of combined instrumentation are established in the treatment of eardrum lesions, as a refinement of the technical training application in microsurgery and assisted endoscopy in the transcochlear and translaberintic approaches and otoneurology areas. PMID:22754733

  9. A Combined Approach to Emotion Detection in Suicide Notes

    PubMed Central

    Pak, Alexander; Bernhard, Delphine; Paroubek, Patrick; Grouin, Cyril

    2012-01-01

    In this paper, we present the system we have developed for participating in the second task of the i2b2/VA 2011 challenge dedicated to emotion detection in clinical records. On the official evaluation, we ranked 6th out of 26 participants. Our best configuration, based upon a combination of both a machine-learning based approach and manually-defined transducers, obtained a 0.5383 global F-measure, while the distribution of the other 26 participants’ results is characterized by mean = 0.4875, stdev = 0.0742, min = 0.2967, max = 0.6139, and median = 0.5027. Combination of machine learning and transducer is achieved by computing the union of results from both approaches, each using a hierarchy of sentiment specific classifiers. PMID:22879766

  10. Using Vision System Technologies to Enable Operational Improvements for Low Visibility Approach and Landing Operations

    NASA Technical Reports Server (NTRS)

    Kramer, Lynda J.; Ellis, Kyle K. E.; Bailey, Randall E.; Williams, Steven P.; Severance, Kurt; Le Vie, Lisa R.; Comstock, James R.

    2014-01-01

    Flight deck-based vision systems, such as Synthetic and Enhanced Vision System (SEVS) technologies, have the potential to provide additional margins of safety for aircrew performance and enable the implementation of operational improvements for low visibility surface, arrival, and departure operations in the terminal environment with equivalent efficiency to visual operations. To achieve this potential, research is required for effective technology development and implementation based upon human factors design and regulatory guidance. This research supports the introduction and use of Synthetic Vision Systems and Enhanced Flight Vision Systems (SVS/EFVS) as advanced cockpit vision technologies in Next Generation Air Transportation System (NextGen) operations. Twelve air transport-rated crews participated in a motion-base simulation experiment to evaluate the use of SVS/EFVS in NextGen low visibility approach and landing operations. Three monochromatic, collimated head-up display (HUD) concepts (conventional HUD, SVS HUD, and EFVS HUD) and two color head-down primary flight display (PFD) concepts (conventional PFD, SVS PFD) were evaluated in a simulated NextGen Chicago O'Hare terminal environment. Additionally, the instrument approach type (no offset, 3 degree offset, 15 degree offset) was experimentally varied to test the efficacy of the HUD concepts for offset approach operations. The data showed that touchdown landing performance were excellent regardless of SEVS concept or type of offset instrument approach being flown. Subjective assessments of mental workload and situation awareness indicated that making offset approaches in low visibility conditions with an EFVS HUD or SVS HUD may be feasible.

  11. Combined approach to the inverse protein folding problem. Final report

    SciTech Connect

    Ruben A. Abagyan

    2000-06-01

    The main scientific contribution of the project ''Combined approach to the inverse protein folding problem'' submitted in 1996 and funded by the Department of Energy in 1997 is the formulation and development of the idea of the multilink recognition method for identification of functional and structural homologues of newly discovered genes. This idea became very popular after they first announced it and used it in prediction of the threading targets for the CASP2 competition (Critical Assessment of Structure Prediction).

  12. Development of a Combination Approach for Seismic Hazard Evaluation

    NASA Astrophysics Data System (ADS)

    Yu, Huai-zhong; Zhou, Fa-ren; Zhu, Qing-yong; Zhang, Xiao-tao; Zhang, Yong-xian

    2016-01-01

    We developed a synth esis approach to augment current techniques for seismic hazard evaluation by combining four previously unrelated subjects: the pattern informatics (PI), load/unload response ratio (LURR), state vector (SV), and accelerating moment release (AMR) methods. Since the PI is proposed in the premise that the change in the seismicity rate is a proxy for the change in the tectonic stress, this method is used to quantify localized changes surrounding the epicenters of large earthquakes to objectively quantify the anomalous areas (hot spots) of the upcoming events. On the short-to-intermediate-term estimation, we apply the LURR, SV, and AMR methods to examine the hazard regions derived from the PI hot spots. A predictive study of the 2014 earthquake tendency in Chinese mainland, using the seismic data from 1970-01-01 to 2014-10-01, shows that, during Jan 01 to Oct 31, 2014, most of the M > 5.0 earthquakes, especially the Feb 12 M7.3 Yutian, May 30 M6.1 Yingjiang, Aug. 03 M6.5 Ludian, and Oct 07 M6.6 earthquakes, occurred in the seismic hazard regions predicted. Comparing the predictions produced by the PI and combination approaches, it is clear that, by using the combination approach, we can screen out the false-alarm regions from the PI estimation, without reducing the hit rate, and therefore effectively augment the predictive power of current techniques. This provided evidence that the multi-method combination approach may be a useful tool to detect precursory information of future large earthquakes.

  13. A distributed computing approach to mission operations support. [for spacecraft

    NASA Technical Reports Server (NTRS)

    Larsen, R. L.

    1975-01-01

    Computing mission operation support includes orbit determination, attitude processing, maneuver computation, resource scheduling, etc. The large-scale third-generation distributed computer network discussed is capable of fulfilling these dynamic requirements. It is shown that distribution of resources and control leads to increased reliability, and exhibits potential for incremental growth. Through functional specialization, a distributed system may be tuned to very specific operational requirements. Fundamental to the approach is the notion of process-to-process communication, which is effected through a high-bandwidth communications network. Both resource-sharing and load-sharing may be realized in the system.

  14. Combining results of microarray experiments: a rank aggregation approach.

    PubMed

    DeConde, Robert P; Hawley, Sarah; Falcon, Seth; Clegg, Nigel; Knudsen, Beatrice; Etzioni, Ruth

    2006-01-01

    As technology for microarray analysis becomes widespread, it is becoming increasingly important to be able to compare and combine the results of experiments that explore the same scientific question. In this article, we present a rank-aggregation approach for combining results from several microarray studies. The motivation for this approach is twofold; first, the final results of microarray studies are typically expressed as lists of genes, rank-ordered by a measure of the strength of evidence that they are functionally involved in the disease process, and second, using the information on this rank-ordered metric means that we do not have to concern ourselves with data on the actual expression levels, which may not be comparable across experiments. Our approach draws on methods for combining top-k lists from the computer science literature on meta-search. The meta-search problem shares several important features with that of combining microarray experiments, including the fact that there are typically few lists with many elements and the elements may not be common to all lists. We implement two meta-search algorithms, which use a Markov chain framework to convert pairwise preferences between list elements into a stationary distribution that represents an aggregate ranking (Dwork et al, 2001). We explore the behavior of the algorithms in hypothetical examples and a simulated dataset and compare their performance with that of an algorithm based on the order-statistics model of Thurstone (Thurstone, 1927). We apply all three algorithms to aggregate the results of five microarray studies of prostate cancer.

  15. Operator assistant systems - An experimental approach using a telerobotics application

    NASA Technical Reports Server (NTRS)

    Boy, Guy A.; Mathe, Nathalie

    1993-01-01

    This article presents a knowledge-based system methodology for developing operator assistant (OA) systems in dynamic and interactive environments. This is a problem both of training and design, which is the subject of this article. Design includes both design of the system to be controlled and design of procedures for operating this system. A specific knowledge representation is proposed for representing the corresponding system and operational knowledge. This representation is based on the situation recognition and analytical reasoning paradigm. It tries to make explicit common factors involved in both human and machine intelligence, including perception and reasoning. An OA system based on this representation has been developed for space telerobotics. Simulations have been carried out with astronauts and the resulting protocols have been analyzed. Results show the relevance of the approach and have been used for improving the knowledge representation and the OA architecture.

  16. Operator assistant systems - An experimental approach using a telerobotics application

    NASA Technical Reports Server (NTRS)

    Boy, Guy A.; Mathe, Nathalie

    1993-01-01

    This article presents a knowledge-based system methodology for developing operator assistant (OA) systems in dynamic and interactive environments. This is a problem both of training and design, which is the subject of this article. Design includes both design of the system to be controlled and design of procedures for operating this system. A specific knowledge representation is proposed for representing the corresponding system and operational knowledge. This representation is based on the situation recognition and analytical reasoning paradigm. It tries to make explicit common factors involved in both human and machine intelligence, including perception and reasoning. An OA system based on this representation has been developed for space telerobotics. Simulations have been carried out with astronauts and the resulting protocols have been analyzed. Results show the relevance of the approach and have been used for improving the knowledge representation and the OA architecture.

  17. Theoretical linear approach to the combined man-manipulator system in manual control of an aircraft

    NASA Technical Reports Server (NTRS)

    Brauser, K.

    1981-01-01

    An approach to the calculation of the dynamic characteristics of the combined man manipulator system in manual aircraft control was derived from a model of the neuromuscular system. This model combines the neuromuscular properties of man with the physical properties of the manipulator system which is introduced as pilot manipulator model into the manual aircraft control. The assumption of man as a quasilinear and time invariant control operator adapted to operating states, depending on the flight phases, of the control system gives rise to interesting solutions of the frequency domain transfer functions of both the man manipulator system and the closed loop pilot aircraft control system. It is shown that it is necessary to introduce the complete precision pilot manipulator model into the closed loop pilot aircraft transfer function in order to understand the well known handling quality criteria, and to derive these criteria directly from human operator properties.

  18. Intra-operative vertebroplasty combined with posterior cord decompression. A report of twelve cases.

    PubMed

    Allegretti, Luca; Mavilio, Nicola; Fiaschi, Pietro; Bragazzi, Roberto; Pacetti, Mattia; Castelletti, Lara; Saitta, Laura; Castellan, Lucio

    2014-10-31

    Percutaneous vertebroplasty (VP) is a minimally invasive technique for the treatment of vertebral pathology providing early vertebral stabilization and pain relief. In cases of vertebral pathology complicated by spinal cord compression with associated neurological deficits, VP alone cannot be performed free of risks. We describe a combined approach in which decompressive laminectomy and intra-operative vertebroplasty (IVP) are performed during a single session. Among the 252 VP performed in our centre in the past three years, 12 patients (12 vertebral levels) with different pathologies (six symptomatic haemangiomas, two metastatic fractures, four osteoporotic fractures) were treated with an open procedure combined with surgery. All cases were treated with decompressive laminectomy and IVP (mono/bipeduncular or median-posterior trans-somatic access). Five patients with symptomatic haemangiomas were treated with endovascular embolization prior to the combined approach. A visual analogue scale (VAS) was applied to assess pain intensity before and after surgery. The neurological deficits were evaluated with an ASIA impairment scale. In all cases benefit from pain and neurological deficits was observed. The mean VAS score decreased from 7.8 to 2.5 after surgery. The ASIA score improved in all cases (five cases from D to E and five cases from C to D). No clinical complications were observed. In one case a CT scan performed after the procedure showed a foraminal accumulation of PMMA, but the patient referred no symptoms. IVP can be successfully applied in different pathologies affecting the vertebrae. In our limited series this approach proved safe and efficient to provide decompression of spinal cord and dural sac and vertebral body stabilization in a single session.

  19. [Assessment of the predisposing risk factors of the complicated postoperative course after combined operations].

    PubMed

    Federov, A V; Kolygin, A V; Berelavichus, S V; Kriger, A G; Chernova, T G; Goncharova, N N; Solodkiĭ, A V

    2013-01-01

    Results of 335 combined operations were analyzed. Men were 89 (27%), women - 246 (73%), the majority of patients were of middle age. 285 (85%) operations included cholecystectomy. 195 (58%) patients had hernioplasty. The third place belonged to vascular operations - 76 (23%). Certain predisposing factors, correlating with the risk of the complicated postoperative course, were marked out. Indications and contraindications to the combined operation were assigned, based on the number of predisposing factors in a patient. Considering the increased risk of intraoperative complications during the combined operation (increased duration, blood loss), participation of highly experienced surgeons and use of modern high-tech equipment seem to be reasonable. The general results of the analysis prove that combined operations are effective, safe and economically beneficial.

  20. Combining multiple single-reference transmissibility functions in a unique matrix formulation for operational modal analysis

    NASA Astrophysics Data System (ADS)

    Devriendt, C.; Weijtjens, W.; De Sitter, G.; Guillaume, P.

    2013-10-01

    In recent years, the authors have proposed an innovative approach for Operational Modal Analysis based on transmissibility measurements. A method was proposed based on combining 2 single-reference transmissibility functions that were obtained during 2 different loading conditions. However in practice one in general has access to multiple transmissibility functions and perhaps even multiple loading conditions. In this paper a new method is introduced that combines all the measured single-reference transmissibility functions in a unique matrix formulation in order to identify system poles. It will be shown that each element of the pseudo-inverse of this matrix is a rational function with poles equal to the system poles. The proposed method reduces the risk to miss system poles and to identify extra non-physical poles. Therefore the method increases the usability and reliability of transmissibility based operational modal analysis (TOMA). The method will be demonstrated and validated by means of an experiment on a beam excited at multiple inputs for three different loading conditions.

  1. Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy.

    PubMed

    Swart, Maarten; Verbrugge, Inge; Beltman, Joost B

    2016-01-01

    In healthy individuals, immune-checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these molecules to evade eradication by the immune system. Over the past years, immune-checkpoint blockade of cytotoxic T lymphocyte antigen-4 and programed death-1 emerged as promising strategies to activate antitumor cytotoxic T cell responses. Although complete regression and long-term survival is achieved in some patients, not all patients respond. This review describes promising, novel combination approaches involving immune-checkpoint blockade in the context of the cancer-immunity cycle, aimed at increasing response rates to the single treatments. Specifically, we discuss combinations that promote antigen release and presentation, that further amplify T cell activation, that inhibit trafficking of regulatory T cells or MSDCs, that stimulate intratumoral T cell infiltration, that increase cancer recognition by T cells, and that stimulate tumor killing.

  2. Combination Approaches with Immune-Checkpoint Blockade in Cancer Therapy

    PubMed Central

    Swart, Maarten; Verbrugge, Inge; Beltman, Joost B.

    2016-01-01

    In healthy individuals, immune-checkpoint molecules prevent autoimmune responses and limit immune cell-mediated tissue damage. Tumors frequently exploit these molecules to evade eradication by the immune system. Over the past years, immune-checkpoint blockade of cytotoxic T lymphocyte antigen-4 and programed death-1 emerged as promising strategies to activate antitumor cytotoxic T cell responses. Although complete regression and long-term survival is achieved in some patients, not all patients respond. This review describes promising, novel combination approaches involving immune-checkpoint blockade in the context of the cancer-immunity cycle, aimed at increasing response rates to the single treatments. Specifically, we discuss combinations that promote antigen release and presentation, that further amplify T cell activation, that inhibit trafficking of regulatory T cells or MSDCs, that stimulate intratumoral T cell infiltration, that increase cancer recognition by T cells, and that stimulate tumor killing. PMID:27847783

  3. A combined mitigation/geoengineering approach to climate stabilization.

    PubMed

    Wigley, T M L

    2006-10-20

    Projected anthropogenic warming and increases in CO2 concentration present a twofold threat, both from climate changes and from CO2 directly through increasing the acidity of the oceans. Future climate change may be reduced through mitigation (reductions in greenhouse gas emissions) or through geoengineering. Most geoengineering approaches, however, do not address the problem of increasing ocean acidity. A combined mitigation/geoengineering strategy could remove this deficiency. Here we consider the deliberate injection of sulfate aerosol precursors into the stratosphere. This action could substantially offset future warming and provide additional time to reduce human dependence on fossil fuels and stabilize CO2 concentrations cost-effectively at an acceptable level.

  4. How to select combination operators for fuzzy expert systems using CRI

    NASA Technical Reports Server (NTRS)

    Turksen, I. B.; Tian, Y.

    1992-01-01

    A method to select combination operators for fuzzy expert systems using the Compositional Rule of Inference (CRI) is proposed. First, fuzzy inference processes based on CRI are classified into three categories in terms of their inference results: the Expansion Type Inference, the Reduction Type Inference, and Other Type Inferences. Further, implication operators under Sup-T composition are classified as the Expansion Type Operator, the Reduction Type Operator, and the Other Type Operators. Finally, the combination of rules or their consequences is investigated for inference processes based on CRI.

  5. Solving the power flow equations: a monotone operator approach

    SciTech Connect

    Dvijotham, Krishnamurthy; Low, Steven; Chertkov, Michael

    2015-07-21

    The AC power flow equations underlie all operational aspects of power systems. They are solved routinely in operational practice using the Newton-Raphson method and its variants. These methods work well given a good initial “guess” for the solution, which is always available in normal system operations. However, with the increase in levels of intermittent generation, the assumption of a good initial guess always being available is no longer valid. In this paper, we solve this problem using the theory of monotone operators. We show that it is possible to compute (using an offline optimization) a “monotonicity domain” in the space of voltage phasors. Given this domain, there is a simple efficient algorithm that will either find a solution in the domain, or provably certify that no solutions exist in it. We validate the approach on several IEEE test cases and demonstrate that the offline optimization can be performed tractably and the computed “monotonicity domain” includes all practically relevant power flow solutions.

  6. Conflicting approaches: Operant psychology arrives at a primate laboratory

    PubMed Central

    Dewsbury, Donald A.

    2003-01-01

    During a brief period, from 1955 to 1957, behavior analysts, primarily Charles Ferster, Roger Kelleher, and John Falk, conducted research on chimpanzees at the Yerkes Laboratories of Primate Biology in Orange Park, Florida. This was a time of conflict between operant conditioners and more traditional experimental psychologists at the national level, and there was a similar conflict at the local level in Orange Park. The principal overt issues concerned the use of deprivation procedures, the apparatus utilized, and the naming of animals, although more fundamental differences probably set the occasion for the disputes. The conflicts in Orange Park can be seen as a microcosm of the broader conflicts that occurred during a period when the operant approach was being extended and applied more broadly than before. PMID:22478406

  7. A Bayesian approach for combining thermal and hydraulic data

    NASA Astrophysics Data System (ADS)

    Woodbury, Allan D.

    Incorporating temperatures into a modeling effort can take many forms, and both temperatures and hydrologic data can be combined qualitatively and quantitatively. In the latter category, the least formal would be in calibration, followed by parameter estimation and finally by full-inversion. This paper discusses information-based (specifically Bayesian) approaches of incorporating hydraulic parameters and potentials like temperature and hydraulic head together in a formal procedure. This paper reviews the generalized inverse problem for groundwater and heat; discusses Bayesian solutions to inverse problems; empirical and hierarchical Bayes, upscaling and cokriging and Bayesian interpolation. Along these lines, a list of suggested references is provided, along with suitable mentioning of benchmark papers, monographs and textbooks on the subject. The technique described in this paper revolves around shallow, low-temperature groundwater flow systems; and that entails steady 2-D fluid and heat flow. The methodology utilizes a perturbation technique to linearize and then couple the governing equations. For the perturbation approach to work, fluid properties must be decoupled from the temperature field. Once this is done, and through the finite element method, a block-linear system of data, kernel, and model parameters is developed. Two end-members and one set of joint inverse examples are presented. The two end-members are pure heat conduction (an application of Bayesian inversion to Paleoclimate reconstructions), and a pure-groundwater problem which is an example application to the Edwards Aquifer in Texas. Lastly, generic examples of combinations of transmissivity, hydraulic head and temperatures are presented.

  8. Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI

    PubMed Central

    Fox, Michael D.; Qian, Tianyi; Madsen, Joseph R.; Wang, Danhong; Li, Meiling; Ge, Manling; Zuo, Huan-cong; Groppe, David M.; Mehta, Ashesh D.; Hong, Bo; Liu, Hesheng

    2016-01-01

    Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20 years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent motor cortex. Accuracy, sensitivity, and specificity of our approach are quantified through comparison with electrical cortical stimulation mapping in eight patients with intractable epilepsy. Broad applicability and reproducibility of our approach is demonstrated through prospective replication in an independent dataset of six patients from a different center. In both cohorts and every individual patient, we see a significant improvement in signal to noise and mapping accuracy independent of threshold, quantified using receiver operating characteristic curves. Collectively, our results suggest that modifying the processing of fMRI data to incorporate both task-based and spontaneous activity significantly improves functional localization in pre-operative patients. Because this method requires no additional scan time or modification to conventional pre-operative data acquisition protocols it could have widespread utility. PMID:26408860

  9. Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.

    PubMed

    Fox, Michael D; Qian, Tianyi; Madsen, Joseph R; Wang, Danhong; Li, Meiling; Ge, Manling; Zuo, Huan-Cong; Groppe, David M; Mehta, Ashesh D; Hong, Bo; Liu, Hesheng

    2016-01-01

    Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent motor cortex. Accuracy, sensitivity, and specificity of our approach are quantified through comparison with electrical cortical stimulation mapping in eight patients with intractable epilepsy. Broad applicability and reproducibility of our approach are demonstrated through prospective replication in an independent dataset of six patients from a different center. In both cohorts and every individual patient, we see a significant improvement in signal to noise and mapping accuracy independent of threshold, quantified using receiver operating characteristic curves. Collectively, our results suggest that modifying the processing of fMRI data to incorporate both task-based and spontaneous activity significantly improves functional localization in pre-operative patients. Because this method requires no additional scan time or modification to conventional pre-operative data acquisition protocols it could have widespread utility.

  10. Comparing Postprocessing Approaches to Calibrating Operational River Discharge Forecasts

    NASA Astrophysics Data System (ADS)

    Hopson, T. M.; Webster, P. J.; Wood, A. W.

    2010-12-01

    With rare exceptions, current operational ensemble weather and hydrologic forecast systems require a final post-processing step to steer the forecast products towards satisfying the twin constraints of greater reliability while retaining (or enhancing) forecast sharpness. Such post-processing of model output can be viewed as an extension of the modeling effort itself, such as in the case of under-dispersive ensemble forecasts, where post-processing of the ensemble dispersion can implicitly account for missing scales of variability or mis-representation of physical processes. Over the last decade a number of different approaches have emerged that show consistent utility in calibrating ensembles derived from a variety of forecasting systems. In this work we compare and contrast four such approaches under differing operational constraints (e.g. data size limitations): logistic regression, an analogue approach, Bayesian model averaging, and quantile regression. The setting for this study is the Climate Forecasting Applications for Bangladesh (CFAB) forecast system, which over the last decade has been providing operational probabilistic forecasts of severe flooding of the Brahmaputra and Ganges Rivers as part of a humanitarian effort to mitigate the impacts of these events on the country of Bangladesh. The flood forecasting system developed utilizes weather forecast uncertainty information provided by the European Centre for Medium-Range Weather Forecasts (ECMWF) ensemble weather forecasts, rain gauge and satellite-derived precipitation estimates from NASA and NOAA, along with near-real-time river stage observations provided by the Flood Forecasting and Warning Centre of Bangladesh. This paper will discuss both the results of the post-processing comparison study more generally, and also within the unique context of this ongoing flood forecasting effort for Bangladesh.

  11. [A Combination of Young's and Grice's Operation in Pes Planovalgus in Children with Cerebral Palsy.].

    PubMed

    Smetana, V; Schejbalová, A

    1997-01-01

    The authors describe a combination of operations according to Young and Grice, i.e. a combination of suspension of the os naviculare on the anterior tibial muscle for modelling the longitudinal arch of the foot with extraarticular talocalcanear arthrodesis, when dealing with neurogenic deformities of the sole in cerebral palsy in children, and evaluate the results of the operation. In general the authors draw attention to certain changes in the clinical picture of cerebral palsy, in particular a more frequent incidence of deformities of the soles which in recent years shifted from the original age of 6-8 years to the age 4-3 years. The combination of the mentioned operations improves the reposition of the soles and thus the general results of Grice's operation which is basic in deformities of the sole in surgery of celebral palsy. Young's operation can be performed in young children also separately. However, it does not produce permanent results without a secondary Grice's operation. It can be implemented in a second stage. Young's operation cannot be made unless there is a sufficiently strong anterior tibial muscle (at least grade 4 in the muscle test). Thus it cannot be performed in weak pareses. The achieved results (64,9 % excellent, 27,0 % good) fully justify the combination of the above operations. Key words: cerebral palsy (CP), extraarticular talocalcanear arthrodesis, Grice's operation, Young's operation, transposition of the tendon of the anterior tibial muscle across the os naviculare.

  12. A three-phase approach for operating theatre schedules.

    PubMed

    Testi, Angela; Tanfani, Elena; Torre, Giancarlo

    2007-06-01

    In this paper we develop a three-phase, hierarchical approach for the weekly scheduling of operating rooms. This approach has been implemented in one of the surgical departments of a public hospital located in Genova (Genoa), Italy. Our aim is to suggest an integrated way of facing surgical activity planning in order to improve overall operating theatre efficiency in terms of overtime and throughput as well as waiting list reduction, while improving department organization. In the first phase we solve a bin packing-like problem in order to select the number of sessions to be weekly scheduled for each ward; the proposed and original selection criterion is based upon an updated priority score taking into proper account both the waiting list of each ward and the reduction of residual ward demand. Then we use a blocked booking method for determining optimal time tables, denoted Master Surgical Schedule (MSS), by defining the assignment between wards and surgery rooms. Lastly, once the MSS has been determined we use the simulation software environment Witness 2004 in order to analyze different sequencings of surgical activities that arise when priority is given on the basis of a) the longest waiting time (LWT), b) the longest processing time (LPT) and c) the shortest processing time (SPT). The resulting simulation models also allow us to outline possible organizational improvements in surgical activity. The results of an extensive computational experimentation pertaining to the studied surgical department are here given and analyzed.

  13. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    ERIC Educational Resources Information Center

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  14. Parametric Optimization of Some Critical Operating System Functions--An Alternative Approach to the Study of Operating Systems Design

    ERIC Educational Resources Information Center

    Sobh, Tarek M.; Tibrewal, Abhilasha

    2006-01-01

    Operating systems theory primarily concentrates on the optimal use of computing resources. This paper presents an alternative approach to teaching and studying operating systems design and concepts by way of parametrically optimizing critical operating system functions. Detailed examples of two critical operating systems functions using the…

  15. A new systems engineering approach to streamlined science and mission operations for the Far Ultraviolet Spectroscopic Explorer (FUSE)

    NASA Technical Reports Server (NTRS)

    Butler, Madeline J.; Sonneborn, George; Perkins, Dorothy C.

    1994-01-01

    The Mission Operations and Data Systems Directorate (MO&DSD, Code 500), the Space Sciences Directorate (Code 600), and the Flight Projects Directorate (Code 400) have developed a new approach to combine the science and mission operations for the FUSE mission. FUSE, the last of the Delta-class Explorer missions, will obtain high resolution far ultraviolet spectra (910 - 1220 A) of stellar and extragalactic sources to study the evolution of galaxies and conditions in the early universe. FUSE will be launched in 2000 into a 24-hour highly eccentric orbit. Science operations will be conducted in real time for 16-18 hours per day, in a manner similar to the operations performed today for the International Ultraviolet Explorer. In a radical departure from previous missions, the operations concept combines spacecraft and science operations and data processing functions in a single facility to be housed in the Laboratory for Astronomy and Solar Physics (Code 680). A small missions operations team will provide the spacecraft control, telescope operations and data handling functions in a facility designated as the Science and Mission Operations Center (SMOC). This approach will utilize the Transportable Payload Operations Control Center (TPOCC) architecture for both spacecraft and instrument commanding. Other concepts of integrated operations being developed by the Code 500 Renaissance Project will also be employed for the FUSE SMOC. The primary objective of this approach is to reduce development and mission operations costs. The operations concept, integration of mission and science operations, and extensive use of existing hardware and software tools will decrease both development and operations costs extensively. This paper describes the FUSE operations concept, discusses the systems engineering approach used for its development, and the software, hardware and management tools that will make its implementation feasible.

  16. [Fronto-lateral laryngectomy using a combined endolaryngeal external approach].

    PubMed

    Conticello, S; Biondi, S; Ferlito, S

    1997-10-01

    Functional laryngectomies-whether subtotal (with significant demolition) or conservative (with limited latero-frontal and frontal demolition)-can, at times, lead to significant post operative functional sequelae. Negative outcomes method proposed calls for an internal, endolaryngeal approach along with an external approach. The internal approach makes it possible to carefully delimit the posterior extension of the laryngeal neoplasm. The external approach, on the other hand, makes it possible to remove the anterior commissure and part of one or both vocal cords in a single unit together with a smaller portion of the thyroid cartilage. In particular, the endolaryngeal approach using suspension microlaryngoscopy makes it possible to section the laryngeal structures all the way up to the internal surface of the thyroid cartilage and, anteriorly, along the midline from the incision to the lower edge of the cartilage. From above the larynx is opened by means of a transfixed section of the thyroid membrane and of the epiglottis at the upper edge of the thyroid cartilage. The ends of the section are joined with the upper ends of the section prepared using the endolaryngeal approach. Cranio-caudal dissection of the internal perichondrium of the thyroid larynx is then performed, from behind, all the way to the endolaryngeal sections and, from below, to the point where the cord ligaments are inserted. The larynx is opened from below by means of a horizontal section in the crico-thyroid membrane at the upper edge of the cricoid cartilage. The trapezoidal section of the lower part of the protruding corner of the thyroid cartilage. After having joined the edges of the crico-thyroid section with the lower edge of the endolaryngeal sections, the entire piece is then removed in a single unit. This method, for treatment of carcinoma of the anterior commissure and of the anterior portion of one or both vocal cords (T1 and T2 N0 M0), must be used after accurate clinical evaluation

  17. A Simulation-Based Approach to Training Operational Cultural Competence

    NASA Technical Reports Server (NTRS)

    Johnson, W. Lewis

    2010-01-01

    Cultural knowledge and skills are critically important for military operations, emergency response, or any job that involves interaction with a culturally diverse population. However, it is not obvious what cultural knowledge and skills need to be trained, and how to integrate that training with the other training that trainees must undergo. Cultural training needs to be broad enough to encompass both regional (culture-specific) and cross-cultural (culture-general) competencies, yet be focused enough to result in targeted improvements in on-the-job performance. This paper describes a comprehensive instructional development methodology and training technology framework that focuses cultural training on operational needs. It supports knowledge acquisition, skill acquisition, and skill transfer. It supports both training and assessment, and integrates with other aspects of operational skills training. Two training systems will be used to illustrate this approach: the Virtual Cultural Awareness Trainer (VCAT) and the Tactical Dari language and culture training system. The paper also discusses new and emerging capabilities that are integrating cultural competence training more strongly with other aspects of training and mission rehearsal.

  18. Vortex flap flight test operations, a safe approach

    NASA Technical Reports Server (NTRS)

    Dicarlo, Daniel J.; Elliott, James R.

    1993-01-01

    A flight test experiment was conducted at the Langley Research Center to evaluate a wing leading-edge vortex flap concept designed for use on an aircraft with highly swept wings. The flap concept was designed as a modification to the wing leading edge of an F-106B airplane. The flight testing required operations at conditions that would exceed the structural load envelope of the basic airplane in order to acquire desired research data for the modified configuration. Accordingly, the operational envelope of the modified aircraft was incrementally expanded and real-time monitoring of airframe strains at critical wing locations was mandated to insure safety of flight. The flight tests were conducted in two phases: Phase I to establish baseline data with the unmodified wing, and Phase II to determine the effects of the vortex flap on performance, handling qualities, and flow field characteristics. This paper focuses on a description of the approach and procedures used to provide the strain-gage monitoring to insure structural integrity. Highlights of the wing modification and the overall operation are also included. Within a -year period, 110 research flights were successfully completed, providing researchers with sufficient data to assess the potential benefits ascribed to the vortex flap concept without encountering severe structural problems or mishaps.

  19. Wavelet Approach for Operational Gamma Spectral Peak Detection - Preliminary Assessment

    SciTech Connect

    ,

    2012-02-01

    Gamma spectroscopy for radionuclide identifications typically involves locating spectral peaks and matching the spectral peaks with known nuclides in the knowledge base or database. Wavelet analysis, due to its ability for fitting localized features, offers the potential for automatic detection of spectral peaks. Past studies of wavelet technologies for gamma spectra analysis essentially focused on direct fitting of raw gamma spectra. Although most of those studies demonstrated the potentials of peak detection using wavelets, they often failed to produce new benefits to operational adaptations for radiological surveys. This work presents a different approach with the operational objective being to detect only the nuclides that do not exist in the environment (anomalous nuclides). With this operational objective, the raw-count spectrum collected by a detector is first converted to a count-rate spectrum and is then followed by background subtraction prior to wavelet analysis. The experimental results suggest that this preprocess is independent of detector type and background radiation, and is capable of improving the peak detection rates using wavelets. This process broadens the doors for a practical adaptation of wavelet technologies for gamma spectral surveying devices.

  20. Multiport Combined Endoscopic Approach to Nonembolized Juvenile Nasopharyngeal Angiofibroma with Parapharyngeal Extension: An Emerging Concept

    PubMed Central

    Bhatia Sharma, Shilpee; Nahata Gattani, Vijayshree

    2016-01-01

    Background. Surgical approaches to the parapharyngeal space (PPS) are challenging by virtue of deep location and neurovascular content. Juvenile Nasopharyngeal Angiofibroma (JNA) is a formidable hypervascular tumor that involves multiple compartments with increase in size. In tumors with extension to parapharyngeal space, the endonasal approach was observed to be inadequate. Combined Endoscopic Endonasal Approaches and Endoscopic Transoral Surgery (EEA-ETOS) approach has provided a customized alternative of multicorridor approach to access JNA for its safe and efficient resection. Methods. The study demonstrates a case series of patients of JNA with prestyloid parapharyngeal space extension operated by endoscopic endonasal and endoscopic transoral approach for tumor excision. Results. The multiport EEA-ETOS approach was used to provide wide exposure to access JNA in parapharyngeal space. No major complications were observed. No conversion to external approach was required. Postoperative morbidity was low and postoperative scans showed no residual tumor. A one-year follow-up was maintained and there was no evidence of disease recurrence. Conclusion. Although preliminary, our experience demonstrates safety and efficacy of multiport approach in providing access to multiple compartments, facilitating total excision of JNA in selected cases. PMID:28101106

  1. Ranking of characteristic features in combined wrapper approaches to selection.

    PubMed

    Stańczyk, Urszula

    The performance of a classification system of any type can suffer from irrelevant or redundant data, contained in characteristic features that describe objects of the universe. To estimate relevance of attributes and select their subset for a constructed classifier typically either a filter, wrapper, or an embedded approach, is implemented. The paper presents a combined wrapper framework, where in a pre-processing step, a ranking of variables is established by a simple wrapper model employing sequential backward search procedure. Next, another predictor exploits this resulting ordering of features in their reduction. The proposed methodology is illustrated firstly for a binary classification task of authorship attribution from stylometric domain, and then for additional verification for a waveform dataset from UCI machine learning repository.

  2. Combining genomic and proteomic approaches for epigenetics research

    PubMed Central

    Han, Yumiao; Garcia, Benjamin A

    2014-01-01

    Epigenetics is the study of changes in gene expression or cellular phenotype that do not change the DNA sequence. In this review, current methods, both genomic and proteomic, associated with epigenetics research are discussed. Among them, chromatin immunoprecipitation (ChIP) followed by sequencing and other ChIP-based techniques are powerful techniques for genome-wide profiling of DNA-binding proteins, histone post-translational modifications or nucleosome positions. However, mass spectrometry-based proteomics is increasingly being used in functional biological studies and has proved to be an indispensable tool to characterize histone modifications, as well as DNA–protein and protein–protein interactions. With the development of genomic and proteomic approaches, combination of ChIP and mass spectrometry has the potential to expand our knowledge of epigenetics research to a higher level. PMID:23895656

  3. A combined geochemical and hydrological approach for understanding macronutrient sources

    NASA Astrophysics Data System (ADS)

    Lapworth, Dan J.; Gooddy, Daren C.; Kent, Flo; Heaton, Tim H. E.; Cole, Steven J.; Allen, Debbie

    2013-09-01

    This study employed complementary geochemical techniques and distributed hydrological modelling to investigate multiple sources of catchment macronutrients and characterise their changes in contrasting storm and baseflow conditions. This approach was demonstrated for the Beult catchment in the county of Kent (England), a designated Site of Special Scientific Interest (SSSI) indentified as failing to meet water quality standards for key nutrients under the Water Framework Directive. Significant changes in nutrient stoichiometry and bioavailability are observed for surface waters under contrasting flow regimes. Soluble reactive phosphorus (SRP) concentrations are approximately twice as high during baseflow compared to high flow, while the inverse is true for particulate, colloidal and dissolved hydrolysable phosphorus, dissolved organic carbon and nitrate. Nitrogen (N):phosphorus (P) ratios are lower during baseflow for most surface waters impacted by diffuse sources of pollution. Fluorescence indices of dissolved organic matter (DOM) show that waste water inputs may be locally important sources of more complex low molecular weight DOM, particularly during baseflow. Nitrate N and O isotope signatures, combined with other dissolved chemical tracers, confirm the dominance of wastewater N inputs at sites downsteam of sewerage treatment works during baseflow, with a shift towards the soil N pool in surface waters across the catchment during high flow. Distributed hydrological modelling using the Grid-to-Grid model reveal areas with the greatest runoff also export higher N and P concentrations, and hence deliver a greater flux of macronutrients, while forested areas with low nutrient concentrations reduce runoff and nutrient fluxes. During periods of high runoff, nested sampling indicates that nutrient fluxes scale with catchment area. This combined approach enables a more thorough assessment of the macronutrient sources and dynamics, better informing management options

  4. An approach for formalising the supply chain operations

    NASA Astrophysics Data System (ADS)

    Zdravković, Milan; Panetto, Hervé; Trajanović, Miroslav; Aubry, Alexis

    2011-11-01

    Reference models play an important role in the knowledge management of the various complex collaboration domains (such as supply chain networks). However, they often show a lack of semantic precision and, they are sometimes incomplete. In this article, we present an approach to overcome semantic inconsistencies and incompleteness of the Supply Chain Operations Reference (SCOR) model and hence improve its usefulness and expand the application domain. First, we describe a literal web ontology language (OWL) specification of SCOR concepts (and related tools) built with the intention to preserve the original approach in the classification of process reference model entities, and hence enable the effectiveness of usage in original contexts. Next, we demonstrate the system for its exploitation, in specific - tools for SCOR framework browsing and rapid supply chain process configuration. Then, we describe the SCOR-Full ontology, its relations with relevant domain ontology and show how it can be exploited for improvement of SCOR ontological framework competence. Finally, we elaborate the potential impact of the presented approach, to interoperability of systems in supply chain networks.

  5. A Final Approach Trajectory Model for Current Operations

    NASA Technical Reports Server (NTRS)

    Gong, Chester; Sadovsky, Alexander

    2010-01-01

    Predicting accurate trajectories with limited intent information is a challenge faced by air traffic management decision support tools in operation today. One such tool is the FAA's Terminal Proximity Alert system which is intended to assist controllers in maintaining safe separation of arrival aircraft during final approach. In an effort to improve the performance of such tools, two final approach trajectory models are proposed; one based on polynomial interpolation, the other on the Fourier transform. These models were tested against actual traffic data and used to study effects of the key final approach trajectory modeling parameters of wind, aircraft type, and weight class, on trajectory prediction accuracy. Using only the limited intent data available to today's ATM system, both the polynomial interpolation and Fourier transform models showed improved trajectory prediction accuracy over a baseline dead reckoning model. Analysis of actual arrival traffic showed that this improved trajectory prediction accuracy leads to improved inter-arrival separation prediction accuracy for longer look ahead times. The difference in mean inter-arrival separation prediction error between the Fourier transform and dead reckoning models was 0.2 nmi for a look ahead time of 120 sec, a 33 percent improvement, with a corresponding 32 percent improvement in standard deviation.

  6. Antiviral Combination Approach as a Perspective to Combat Enterovirus Infections.

    PubMed

    Galabov, Angel S; Nikolova, Ivanka; Vassileva-Pencheva, Ralitsa; Stoyanova, Adelina

    2015-01-01

    Human enteroviruses distributed worldwide are causative agents of a broad spectrum of diseases with extremely high morbidity, including a series of severe illnesses of the central nervous system, heart, endocrine pancreas, skeleton muscles, etc., as well as the common cold contributing to the development of chronic respiratory diseases, including the chronic obstructive pulmonary disease. The above mentioned diseases along with the significantly high morbidity and mortality in children, as well as in the high-risk populations (immunodeficiencies, neonates) definitely formulate the chemotherapy as the main tool for the control of enterovirus infections. At present, clinically effective antivirals for use in the treatment of enteroviral infection do not exist, in spite of the large amount of work carried out in this field. The main reason for this is the development of drug resistance. We studied the process of development of resistance to the strongest inhibitors of enteroviruses, WIN compounds (VP1 protein hydrophobic pocket blockers), especially in the models in vivo, Coxsackievirus B (CV-B) infections in mice. We introduced the tracing of a panel of phenotypic markers (MIC50 value, plaque shape and size, stability at 50℃, pathogenicity in mice) for characterization of the drug-mutants (resistant and dependent) as a very important stage in the study of enterovirus inhibitors. Moreover, as a result of VP1 RNA sequence analysis performed on the model of disoxaril mutants of CVB1, we determined the molecular basis of the drug-resistance. The monotherapy courses were the only approach used till now. For the first time in the research for anti-enterovirus antivirals our team introduced the testing of combination effect of the selective inhibitors of enterovirus replication with different mode of action. This study resulted in the selection of a number of very effective in vitro double combinations with synergistic effect and a broad spectrum of sensitive

  7. Operative terminology and post-operative management approaches applied to hepatic surgery: Trainee perspectives

    PubMed Central

    Farid, Shahid G; Prasad, K Rajendra; Morris-Stiff, Gareth

    2013-01-01

    Outcomes in hepatic resectional surgery (HRS) have improved as a result of advances in the understanding of hepatic anatomy, improved surgical techniques, and enhanced peri-operative management. Patients are generally cared for in specialist higher-level ward settings with multidisciplinary input during the initial post-operative period, however, greater acceptance and understanding of HRS has meant that care is transferred, usually after 24-48 h, to a standard ward environment. Surgical trainees will be presented with such patients either electively as part of a hepatobiliary firm or whilst covering the service on-call, and it is therefore important to acknowledge the key points in managing HRS patients. Understanding the applied anatomy of the liver is the key to determining the extent of resection to be undertaken. Increasingly, enhanced patient pathways exist in the post-operative setting requiring focus on the delivery of high quality analgesia, careful fluid balance, nutrition and thromboprophlaxis. Complications can occur including liver, renal and respiratory failure, hemorrhage, and sepsis, all of which require prompt recognition and management. We provide an overview of the relevant terminology applied to hepatic surgery, an approach to the post-operative management, and an aid to developing an awareness of complications so as to facilitate better confidence in this complex subgroup of general surgical patients. PMID:23710292

  8. Operative terminology and post-operative management approaches applied to hepatic surgery: Trainee perspectives.

    PubMed

    Farid, Shahid G; Prasad, K Rajendra; Morris-Stiff, Gareth

    2013-05-27

    Outcomes in hepatic resectional surgery (HRS) have improved as a result of advances in the understanding of hepatic anatomy, improved surgical techniques, and enhanced peri-operative management. Patients are generally cared for in specialist higher-level ward settings with multidisciplinary input during the initial post-operative period, however, greater acceptance and understanding of HRS has meant that care is transferred, usually after 24-48 h, to a standard ward environment. Surgical trainees will be presented with such patients either electively as part of a hepatobiliary firm or whilst covering the service on-call, and it is therefore important to acknowledge the key points in managing HRS patients. Understanding the applied anatomy of the liver is the key to determining the extent of resection to be undertaken. Increasingly, enhanced patient pathways exist in the post-operative setting requiring focus on the delivery of high quality analgesia, careful fluid balance, nutrition and thromboprophlaxis. Complications can occur including liver, renal and respiratory failure, hemorrhage, and sepsis, all of which require prompt recognition and management. We provide an overview of the relevant terminology applied to hepatic surgery, an approach to the post-operative management, and an aid to developing an awareness of complications so as to facilitate better confidence in this complex subgroup of general surgical patients.

  9. A combined technologies approach to multilevel groundwater screening

    SciTech Connect

    Tingle, A.R.; Baker, L.; Long, D.D.; Miracle, M.

    1995-12-31

    Rapid characterization of a large volume of groundwater related to a historical fuel spill was performed using a combination of commercially available technologies. The three primary technologies used include (1) a drive-point sampling device (i.e., Geoprobe{reg_sign}); (2) a mobile on-site field laboratory; and (3) a Global Positioning System (GPS). The drive-point sampling device was used to advance 2.5-cm outer dia carbon steel rods and an end rod containing a retractable 61 cm well screen. The rods and screen were advanced to depths of up to 36.5 m below ground surface and acted as a temporary well. Groundwater samples were collected from the screened interval and immediately analyzed in the on-site field laboratory for total petroleum hydrocarbons, benzene, toluene, ethylbenzene, xylenes, and carbon dioxide. Each sample location was determined using the GPS. After the screening phase of the project, two small-diameter permanent wells were installed using drive-point technology. Advantages of combining these technologies in a single field effort include minimization of investigation-derived waste, minimization of formation disturbance, rapid generation of multilevel groundwater screening data to facilitate field decisions, and an overall cost savings when compared to the more conventional drill-rig/screened-auger/local fixed-base laboratory approach.

  10. Spermatozoa quality assessment: a combined holographic and Raman microscopy approach

    NASA Astrophysics Data System (ADS)

    De Angelis, Annalisa; Ferrara, Maria A.; Di Caprio, Giuseppe; Managò, Stefano; Sirleto, Luigi; Coppola, Giuseppe; De Luca, Anna Chiara

    2015-05-01

    Semen analysis is widely used as diagnostic tool for assessing male fertility, controlling and managing the animal reproduction. The most important parameters measured in a semen analysis are the morphology and biochemical alterations. For obtaining such information, non-invasive, label-free and non-destructive techniques have to be used. Digital Holography (DH) combined with Raman Spectroscopy (RS) could represent the perfect candidate for a rapid, non-destructive and high-sensitive morphological and biochemical sperm cell analysis. In this study, DH-RS combined approach is used for a complete analysis of single bovine spermatozoa. High-resolution images of bovine sperm have been obtained by DH microscopy from the reconstruction of a single acquired hologram, highlighting in some cases morphological alterations. Quantitative 3D reconstructions of sperm head, both normal and anomalous, have been studied and an unexpected structure of the post-acrosomal region of the head has been detected. Such anomalies have been also confirmed by Raman imaging analysis, suggesting the protein vibrations as associated Raman marker of the defect.

  11. Accreditation and quality approach in operating theatre departments: the French approach.

    PubMed

    Soudée, M

    2005-01-01

    Since 1996, French health establishments are subjected to a process of evaluating the quality of care, called "accreditation". This process was controlled by ANAES, which, after January 1st, 2005 became the Haute Autorité de Santé (HAS). The accreditation is characterized by a dual process of self-assessment and external audit, leading to four levels of accreditation. In spite of requiring a time-consuming methodology, this approach provides an important means of consolidating the development of the quality approach and re-stimulating the compliance of establishments with standards of safety and vigilance. The professional teams of many French operating theatre departments have been able to use the regulatory and restricting framework of accreditation to organize quality approaches specific to the operative system, supported by the organizational structures of the department such as the operating suite committee, departmental boards and the steering group. Based on quality guidelines including a commitment from the manager and operating suite committee, as well as a quality flow chart and a quality system, these teams describe the main procedures for running the operating theatre. They also organize the follow-up of incidents and undesirable events, along with the risks and points to watch. Audits of the operative system are planned on a regular basis. The second version of the accreditation process considerably reinforces the assessment of professional practices by evaluating the relevance, the risks and the methods of managing care for pathologies. It will make it possible to implement assessments of the health care provided by operating theatre departments and will reinforce the importance of search for quality.

  12. Surgical approach to impacted mandibular third molars--operative classification.

    PubMed

    Abu-El Naaj, Imad; Braun, Refael; Leiser, Yoav; Peled, Micha

    2010-03-01

    The aim of the present study is to suggest a convenient way to classify the position of the impacted third mandibular molar relative to the mandibular canal and to suggest indications for the use of each surgical approach for mandibular third molar extraction. The presented new typing system, Third Molar Classification (TMC), is a simple and easy-to-apply method for the surgical management of mandibular third molars and can be extended for any ectopic or impacted mandibular tooth. There are 3 major types of third molar positions. The second type is subdivided further into 2 subtypes. In the present study, 9 patients with high-risk mandibular third molars were treated according to the present classification and are presented and discussed. Patients typed as TMC IIb were treated with a sagittal split osteotomy approach and patients typed as TMC III were treated with an extraoral approach. The operative classification was successfully implemented in very rare cases of deeply impacted mandibular third molars. In 3 of 9 cases (33%) minor complications included some degree of hypoesthesia using the extraoral approach; these complications resolved spontaneously without the need for any intervention. The present study describes the use of a new surgical classification system for treatment planning in all types of mandibular third molar extractions. We believe that the present classification could help the oral and maxillofacial surgeon in decision-making and limit the possible risks that are present when attempting to extract impacted mandibular third molars. Copyright (c) 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  13. An intercomparison of approaches for improving operational seasonal streamflow forecasts

    NASA Astrophysics Data System (ADS)

    Mendoza, Pablo A.; Wood, Andrew W.; Clark, Elizabeth; Rothwell, Eric; Clark, Martyn P.; Nijssen, Bart; Brekke, Levi D.; Arnold, Jeffrey R.

    2017-07-01

    For much of the last century, forecasting centers around the world have offered seasonal streamflow predictions to support water management. Recent work suggests that the two major avenues to advance seasonal predictability are improvements in the estimation of initial hydrologic conditions (IHCs) and the incorporation of climate information. This study investigates the marginal benefits of a variety of methods using IHCs and/or climate information, focusing on seasonal water supply forecasts (WSFs) in five case study watersheds located in the US Pacific Northwest region. We specify two benchmark methods that mimic standard operational approaches - statistical regression against IHCs and model-based ensemble streamflow prediction (ESP) - and then systematically intercompare WSFs across a range of lead times. Additional methods include (i) statistical techniques using climate information either from standard indices or from climate reanalysis variables and (ii) several hybrid/hierarchical approaches harnessing both land surface and climate predictability. In basins where atmospheric teleconnection signals are strong, and when watershed predictability is low, climate information alone provides considerable improvements. For those basins showing weak teleconnections, custom predictors from reanalysis fields were more effective in forecast skill than standard climate indices. ESP predictions tended to have high correlation skill but greater bias compared to other methods, and climate predictors failed to substantially improve these deficiencies within a trace weighting framework. Lower complexity techniques were competitive with more complex methods, and the hierarchical expert regression approach introduced here (hierarchical ensemble streamflow prediction - HESP) provided a robust alternative for skillful and reliable water supply forecasts at all initialization times. Three key findings from this effort are (1) objective approaches supporting methodologically

  14. Tools and Techniques for a Systematic Approach to Safe Rendezvous and Proximity Operations

    NASA Astrophysics Data System (ADS)

    Taylor, Rob; Rishikof, Brian

    2010-09-01

    Among the most demanding operations facing manned spaceflight is the ability to successfully and safely complete Rendezvous Proximity Operations & Capture(RPOC) operations with a target vehicle. While perhaps made to look routine from a safety perspective for some vehicles and developers regularly docking to the International Space Station(namely the Space Shuttle, and Russian Progress and Soyuz vehicles), international partners and commercial vehicle developers are finding it among the most difficult engineering challenges. Whether docking with the International Space Station in low earth orbit, or rendezvousing with a returning spacecraft in low lunar orbit, successfully and systematically accounting for all the combinations of risks and failures which lead to failed rendezvous or collisions can be daunting. Systems such as propulsion, avionics, software, and command and data handling(C&DH) must all work as a single integrated system; and the guidance, navigation, and control(GN&C) systems arguably forms the heart of that unit. In response to this challenge, Odyssey Space Research(Odyssey) utilizes their core GN&C engineering competencies, systems engineering capabilities and associated simulation tools to address the safety of RPOC. These simulations provide for high-level mission scenario analysis, systems design, mission planning, monitoring, and implementation, covering all flight phases of rendezvous from orbit insertion, phasing and transfer orbits, far-range rendezvous operations, proximity operations, and capture. Combined with a systems engineering approach, it allows our team to analyze functional system capabilities, propose design modifications and then perform the safety engineering aspect of evaluating that vehicle’s safety compliance. The simulation, modeling and analysis tools(such as domain specific RPOC models, and visualization and virtual reality) allow for detailed design and development and/or help provide the independent assessment

  15. Combining Operations Management and Information Systems Curricula: Assessing Alumni Preparations for the Workforce

    ERIC Educational Resources Information Center

    Silva, David; McFadden, Kathleen L.

    2005-01-01

    The purpose of this study is to explore how well a curriculum that combines operations management and information systems uniquely prepares students for the workforce. To address our research questions, a Web-based survey was developed. We sent our survey to 203 alumni that graduated from the Department of Operations Management and Information…

  16. Combining Operations Management and Information Systems Curricula: Assessing Alumni Preparations for the Workforce

    ERIC Educational Resources Information Center

    Silva, David; McFadden, Kathleen L.

    2005-01-01

    The purpose of this study is to explore how well a curriculum that combines operations management and information systems uniquely prepares students for the workforce. To address our research questions, a Web-based survey was developed. We sent our survey to 203 alumni that graduated from the Department of Operations Management and Information…

  17. 76 FR 13241 - Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License On March 28, 2008, Southern Nuclear Operating Company (SNC), acting on behalf of itself and Georgia Power Company, Oglethorpe Power Corporation...

  18. 76 FR 11822 - Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Southern Nuclear Operating Company; Notice of Availability of Application for a Combined License On March 28, 2008, Southern Nuclear Operating Company (SNC), acting on behalf of itself and Georgia Power Company, Oglethorpe Power Corporation...

  19. Opening Pandora’s Box: The U.S. Army in Combined Contingency Operations.

    DTIC Science & Technology

    1991-05-08

    commonality of objectives; time; personalities; and language. Overcoming these obstacles presents monumental challenges to the combined force in...Larcie Unit Operations; FM 34-37, Echelons Above Coros Intelligence and Electronic Warfare Operations; and FM 34-1, .ntelligence and Electronic

  20. [Emoxipin in combined pharmacological defense of the kidney from ischemia and operative stress (an experimental study)].

    PubMed

    Imamverdiev, S B; Mamedov, R N

    2003-01-01

    The paper presents experimental results of the study of kidney defense from normothermic ischemia and operative stress in interventions with stopping renal circulation. The antiischemic effect of emoxipin was studied in monotherapy and in combination with furosemide and verapamil. The above effect was found positive, especially in response to combined use of emoxipin, furosemide and verapamil.

  1. HANFORD DOUBLE SHELL TANK (DST) THERMAL & SEISMIC PROJECT SUMMARY OF COMBINED THERMAL & OPERATING LOADS

    SciTech Connect

    MACKEY, T.C.

    2006-03-17

    This report summarizes the results of the Double-Shell Tank Thermal and Operating Loads Analysis (TOLA) combined with the Seismic Analysis. This combined analysis provides a thorough, defensible, and documented analysis that will become a part of the overall analysis of record for the Hanford double-shell tanks (DSTs).

  2. Combining operational models and data into a dynamic vessel risk assessment tool for coastal regions

    NASA Astrophysics Data System (ADS)

    Fernandes, R.; Braunschweig, F.; Lourenço, F.; Neves, R.

    2016-02-01

    The technological evolution in terms of computational capacity, data acquisition systems, numerical modelling and operational oceanography is supplying opportunities for designing and building holistic approaches and complex tools for newer and more efficient management (planning, prevention and response) of coastal water pollution risk events. A combined methodology to dynamically estimate time and space variable individual vessel accident risk levels and shoreline contamination risk from ships has been developed, integrating numerical metocean forecasts and oil spill simulations with vessel tracking automatic identification systems (AIS). The risk rating combines the likelihood of an oil spill occurring from a vessel navigating in a study area - the Portuguese continental shelf - with the assessed consequences to the shoreline. The spill likelihood is based on dynamic marine weather conditions and statistical information from previous accidents. The shoreline consequences reflect the virtual spilled oil amount reaching shoreline and its environmental and socio-economic vulnerabilities. The oil reaching shoreline is quantified with an oil spill fate and behaviour model running multiple virtual spills from vessels along time, or as an alternative, a correction factor based on vessel distance from coast. Shoreline risks can be computed in real time or from previously obtained data. Results show the ability of the proposed methodology to estimate the risk properly sensitive to dynamic metocean conditions and to oil transport behaviour. The integration of meteo-oceanic + oil spill models with coastal vulnerability and AIS data in the quantification of risk enhances the maritime situational awareness and the decision support model, providing a more realistic approach in the assessment of shoreline impacts. The risk assessment from historical data can help finding typical risk patterns ("hot spots") or developing sensitivity analysis to specific conditions, whereas real

  3. Combining operational models and data into a dynamic vessel risk assessment tool for coastal regions

    NASA Astrophysics Data System (ADS)

    Fernandes, R.; Braunschweig, F.; Lourenço, F.; Neves, R.

    2015-07-01

    The technological evolution in terms of computational capacity, data acquisition systems, numerical modelling and operational oceanography is supplying opportunities for designing and building holistic approaches and complex tools for newer and more efficient management (planning, prevention and response) of coastal water pollution risk events. A combined methodology to dynamically estimate time and space variable shoreline risk levels from ships has been developed, integrating numerical metocean forecasts and oil spill simulations with vessel tracking automatic identification systems (AIS). The risk rating combines the likelihood of an oil spill occurring from a vessel navigating in a study area - Portuguese Continental shelf - with the assessed consequences to the shoreline. The spill likelihood is based on dynamic marine weather conditions and statistical information from previous accidents. The shoreline consequences reflect the virtual spilled oil amount reaching shoreline and its environmental and socio-economic vulnerabilities. The oil reaching shoreline is quantified with an oil spill fate and behaviour model running multiple virtual spills from vessels along time. Shoreline risks can be computed in real-time or from previously obtained data. Results show the ability of the proposed methodology to estimate the risk properly sensitive to dynamic metocean conditions and to oil transport behaviour. The integration of meteo-oceanic + oil spill models with coastal vulnerability and AIS data in the quantification of risk enhances the maritime situational awareness and the decision support model, providing a more realistic approach in the assessment of shoreline impacts. The risk assessment from historical data can help finding typical risk patterns, "hot spots" or developing sensitivity analysis to specific conditions, whereas real time risk levels can be used in the prioritization of individual ships, geographical areas, strategic tug positioning and

  4. Combining Classifiers Using Their Receiver Operating Characteristics and Maximum Likelihood Estimation*

    PubMed Central

    Haker, Steven; Wells, William M.; Warfield, Simon K.; Talos, Ion-Florin; Bhagwat, Jui G.; Goldberg-Zimring, Daniel; Mian, Asim; Ohno-Machado, Lucila; Zou, Kelly H.

    2010-01-01

    In any medical domain, it is common to have more than one test (classifier) to diagnose a disease. In image analysis, for example, there is often more than one reader or more than one algorithm applied to a certain data set. Combining of classifiers is often helpful, but determining the way in which classifiers should be combined is not trivial. Standard strategies are based on learning classifier combination functions from data. We describe a simple strategy to combine results from classifiers that have not been applied to a common data set, and therefore can not undergo this type of joint training. The strategy, which assumes conditional independence of classifiers, is based on the calculation of a combined Receiver Operating Characteristic (ROC) curve, using maximum likelihood analysis to determine a combination rule for each ROC operating point. We offer some insights into the use of ROC analysis in the field of medical imaging. PMID:16685884

  5. Combining classifiers using their receiver operating characteristics and maximum likelihood estimation.

    PubMed

    Haker, Steven; Wells, William M; Warfield, Simon K; Talos, Ion-Florin; Bhagwat, Jui G; Goldberg-Zimring, Daniel; Mian, Asim; Ohno-Machado, Lucila; Zou, Kelly H

    2005-01-01

    In any medical domain, it is common to have more than one test (classifier) to diagnose a disease. In image analysis, for example, there is often more than one reader or more than one algorithm applied to a certain data set. Combining of classifiers is often helpful, but determining the way in which classifiers should be combined is not trivial. Standard strategies are based on learning classifier combination functions from data. We describe a simple strategy to combine results from classifiers that have not been applied to a common data set, and therefore can not undergo this type of joint training. The strategy, which assumes conditional independence of classifiers, is based on the calculation of a combined Receiver Operating Characteristic (ROC) curve, using maximum likelihood analysis to determine a combination rule for each ROC operating point. We offer some insights into the use of ROC analysis in the field of medical imaging.

  6. Kistler reusable vehicle facility design and operational approach

    NASA Astrophysics Data System (ADS)

    Fagan, D.; McInerney, F.; Johnston, C.; Tolson, B.

    Kistler Aerospace Corporation is designing and developing the K-1, the world's first fully reusable aerospace vehicle to deliver satellites into orbit. The K-1 vehicle test program will be conducted in Woomera, Australia, with commercial operations scheduled to begin shortly afterwards. Both stages of the K-1 will return to the launch site utilizing parachutes and airbags for a soft landing within 24 h after launch. The turnaround flow of the two stages will cycle from landing site to a maintenance/refurbishment facility and through the next launch in only 9 days. Payload processing will occur in a separate facility in parallel with recovery and refurbishment operations. The vehicle design and on-board checkout capability of the avionics system eliminates the need for an abundance of ground checkout equipment. Payload integration, vehicle assembly, and K-1 transport to the launch pad will be performed horizontally, simplifying processing and reducing infrastructure requirements. This simple, innovative, and cost-effective approach will allow Kistler to offer its customers flexible, low-cost, and on-demand launch services.

  7. Operational approach to entanglement and how to certify it

    NASA Astrophysics Data System (ADS)

    Kupczynski, M.

    2016-05-01

    Entangled physical systems are an important resource in quantum information. Many papers were published trying to grasp the meaning of entanglement. It was noticed that a Hilbert space of possible state vectors of compound physical system can be partitioned by introducing various tensor product structures induced by the experimentally accessible observables (interactions and measurements). In this sense, the entanglement is relative to a particular set of experimental capabilities. Inspired by these results some authors claim that in fact all quantum states are entangled. In this paper, we show that this claim is incorrect and we discuss in operational way differences existing between separable and entangled states. A sufficient condition for entanglement is the violation of Bell-CHSH-CH inequalities and/or steering inequalities. Since there exist experiments outside the domain of quantum physics violating these inequalities therefore in the operational approach one cannot say that the entanglement is an exclusive quantum phenomenon. We also explain that an unambiguous experimental certification of the entanglement is a difficult task because classical statistical significance tests may not be trusted if sample homogeneity cannot be tested or is not tested carefully enough.

  8. Enabling CSPA Operations Through Pilot Involvement in Longitudinal Approach Spacing

    NASA Technical Reports Server (NTRS)

    Battiste, Vernol (Technical Monitor); Pritchett, Amy

    2003-01-01

    Several major airports around the United States have, or plan to have, closely-spaced parallel runways. This project complemented current and previous research by examining the pilots ability to control their position longitudinally within their approach stream.This project s results considered spacing for separation from potential positions of wake vortices from the parallel approach. This preventive function could enable CSPA operations to very closely spaced runways. This work also considered how pilot involvement in longitudinal spacing could allow for more efficient traffic flow, by allowing pilots to keep their aircraft within tighter arrival slots then air traffic control (ATC) might be able to establish, and by maintaining space within the arrival stream for corresponding departure slots. To this end, this project conducted several research studies providing an analytic and computational basis for calculating appropriate aircraft spacings, experimental results from a piloted flight simulator test, and an experimental testbed for future simulator tests. The following sections summarize the results of these three efforts.

  9. A combined PLC and CPU approach to multiprocessor control

    SciTech Connect

    Harris, J.J.; Broesch, J.D.; Coon, R.M.

    1995-10-01

    A sophisticated multiprocessor control system has been developed for use in the E-Power Supply System Integrated Control (EPSSIC) on the DIII-D tokamak. EPSSIC provides control and interlocks for the ohmic heating coil power supply and its associated systems. Of particular interest is the architecture of this system: both a Programmable Logic Controller (PLC) and a Central Processor Unit (CPU) have been combined on a standard VME bus. The PLC and CPU input and output signals are routed through signal conditioning modules, which provide the necessary voltage and ground isolation. Additionally these modules adapt the signal levels to that of the VME I/O boards. One set of I/O signals is shared between the two processors. The resulting multiprocessor system provides a number of advantages: redundant operation for mission critical situations, flexible communications using conventional TCP/IP protocols, the simplicity of ladder logic programming for the majority of the control code, and an easily maintained and expandable non-proprietary system.

  10. A combined ANP-delphi approach to evaluate sustainable tourism

    SciTech Connect

    Garcia-Melon, Monica

    2012-04-15

    The evaluation of sustainable tourism strategies promoted by National Parks (NP) related stakeholders is a key concern for NP managers. To help them in their strategic evaluation procedures, in this paper we propose a methodology based on the Analytic Network Process and a Delphi-type judgment-ensuring procedure. The approach aims at involving stakeholders in a participatory and consensus-building process. The methodology was applied to Los Roques NP in Venezuela. The problem included three sustainable tourism strategies defined by the stakeholders: eco-efficient resorts, eco-friendly leisure activities and ecological transportation systems. Representatives of eight stakeholders participated in the methodology. 13 sustainability criteria were selected. Results provide some important insights into the overall philosophy and underlying participants' conception of what sustainable development of Los Roques NP means. This conception is broadly shared by stakeholders as they coincided in the weights of most of the criteria, which were assigned individually through the questionnaire. It is particularly noteworthy that tourists and environmentalists almost fully match in their assessments of criteria but not of the alternatives. Moreover, there is a great agreement in the final assessment. This suggests that the regular contact among the different stakeholders, i.e. tourists with inhabitants, authorities with environmentalists, tour operators with representatives of the ministry, etc. has led to a common understanding of the opportunities and threats for the NP. They all agreed that the procedure enhances participation and transparency and it is a necessary source of information and support for their decisions.

  11. Anatomical study of the cavernous sinus emphasizing operative approaches and related vascular and neural reconstruction.

    PubMed

    Sekhar, L N; Burgess, J; Akin, O

    1987-12-01

    The efficacy of three operative approaches to the cavernous sinus (CS) and the possibilities of vascular and cranial nerve reconstruction in and around the CS were studied in 50 cadaver specimens (25 heads). The lateral operative approach was through the lateral wall, between Cranial Nerves V1 and IV, or between Cranial Nerves V1 and V2. The superior approach was through the superior wall of the CS after removing the anterior clinoid process and unroofing the optic canal. The inferior approach followed the petrous internal carotid artery (ICA) into the CS after an extradural subtemporal exposure or after a combined subtemporal and infratemporal fossa exposure. The different exposures of the spaces of the CS and of the intracavernous structures provided by the superior and the lateral approaches were complementary. The exposure provided by the inferior approach was minimal; however, the junction of the petrous and cavernous ICA was best exposed by this route. The combined subtemporal and infratemporal fossa approach exposed the petrous ICA (for proximal control or for reconstruction) with the greatest ease and with the least temporal lobe retraction. The combination of the superior and lateral approaches and the complete mobilization of the intracavernous ICA facilitated its repair after experimental lacerations. Lacerations of either the inferior and the inferomedial aspects of any portion of the cavernous ICA or of the anterior surface of the posterior vertical segment of the artery were the most difficult to repair. End-to-end anastomosis was more difficult with the posterior third of the artery than with the anterior two-thirds. A vein graft with an average length of 3.5 cm could be sutured from the petrous to the supraclinoid ICA to bypass the cavernous ICA, with an average occlusion time of 45 minutes. End-to-end technique was judged better for the proximal anastomosis, but end (graft)-to-side anastomosis was easier to perform at the distal end because of the

  12. Analysing clinical reasoning characteristics using a combined methods approach

    PubMed Central

    2013-01-01

    individuals. The modest reliability of SCTs and CRPs in this study suggests the need for an increased number of items for testing. Further work is needed to determine the suitability of a combined approach for assessment purposes. PMID:24165290

  13. Integrated operation and management system for a 700MW combined cycle power plant

    SciTech Connect

    Shiroumaru, I. ); Iwamiya, T. ); Fukai, M. )

    1992-03-01

    Yanai Power Plant of the Chugoku Electric Power Co., Inc. (Yamaguchi Pref., Japan) is in the process of constructing a 1400MW state-of-the-art combined cycle power plant. The first phase, a 350MW power plant, started operation on a commercial basis in November, 1990. This power plant has achieved high efficiency and high operability, major features of a combined cycle power plant. The integrated operation and management system of the power plant takes care of operation, maintenance, control of general business, etc., and was built using the latest computer and digital control and communication technologies. This paper reports that it is expected that this system will enhance efficient operation and management for the power plant.

  14. A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis

    PubMed Central

    2011-01-01

    Background Bacterial exported proteins represent key components of the host-pathogen interplay. Hence, we sought to implement a combined approach for characterizing the entire exoproteome of the pathogenic bacterium Corynebacterium pseudotuberculosis, the etiological agent of caseous lymphadenitis (CLA) in sheep and goats. Results An optimized protocol of three-phase partitioning (TPP) was used to obtain the C. pseudotuberculosis exoproteins, and a newly introduced method of data-independent MS acquisition (LC-MSE) was employed for protein identification and label-free quantification. Additionally, the recently developed tool SurfG+ was used for in silico prediction of sub-cellular localization of the identified proteins. In total, 93 different extracellular proteins of C. pseudotuberculosis were identified with high confidence by this strategy; 44 proteins were commonly identified in two different strains, isolated from distinct hosts, then composing a core C. pseudotuberculosis exoproteome. Analysis with the SurfG+ tool showed that more than 75% (70/93) of the identified proteins could be predicted as containing signals for active exportation. Moreover, evidence could be found for probable non-classical export of most of the remaining proteins. Conclusions Comparative analyses of the exoproteomes of two C. pseudotuberculosis strains, in addition to comparison with other experimentally determined corynebacterial exoproteomes, were helpful to gain novel insights into the contribution of the exported proteins in the virulence of this bacterium. The results presented here compose the most comprehensive coverage of the exoproteome of a corynebacterial species so far. PMID:21241507

  15. 14 CFR 121.659 - Initial approach altitude: Domestic and supplemental operations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Initial approach altitude: Domestic and... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.659 Initial approach altitude: Domestic and supplemental operations....

  16. 14 CFR 121.659 - Initial approach altitude: Domestic and supplemental operations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Initial approach altitude: Domestic and... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Dispatching and Flight Release Rules § 121.659 Initial approach altitude: Domestic and supplemental operations....

  17. Inversion problem for singular integral operators: C*-approach

    PubMed Central

    Dynin, Alexander

    1978-01-01

    The inversion problem is solved for a wide class of singular integral operators, in particular for Wiener-Hopf operators in several variables, Mihlin-Calderon-Zygmund operators on bounded domains, and Folland-Stein operators on compact nondegenerate Cauchy-Riemann manifolds. PMID:16592574

  18. Combined vibration and guided wave-based approach for composite panels health assessment

    NASA Astrophysics Data System (ADS)

    Radzienski, Maciej; Cao, Maosen; Wei, Xu; Kudela, Pawel; Ostachowicz, Wieslaw

    2017-04-01

    Various non-destructive testing (NDT) methods have been developed to extract information about state of a structure. Two of them: vibration-based and guided wave-based techniques are one of the most commonly used and well developed. Both approaches can be implemented using Scanning Laser Doppler Vibrometer measurements and excitation by means of piezoelectric transducer. In this paper authors present a combined approached for NDT using successive and simultaneous measurement of both mode shapes and guided waves. Vibration-based damage detection is focused on detection of mode shape singularity, created by material discontinuity. This method utilizes wavelet transform and Teager energy operator for damage indication. Guided wave-based damage detection uses propagating elastic wave energy variation on the specimen surface as well as any changes in wave propagation pattern due to its interaction with material discontinuity as a tool for structural health assessment. Combining this two different techniques can give higher accuracy in defect detection. At the same time any additional specimen preparation are necessary, any set-up changes are required and the all the data can be registered in the same amount of time (simultaneous excitation). To confirm proposed technique a honeycomb core sandwich aluminum plate with debonding is tested. A results obtained with both techniques and combined approach are presented.

  19. Effects of transsylvian-transinsular approach to hypertensive putaminal hematoma operation and electroacupuncture on motor recovery.

    PubMed

    Zhang, Yuhai; Ding, Wei; Yang, Yunxue; Xu, Houchi; Xiong, Feng; Liu, Cunzhi

    2011-09-01

    In this study, a comparison of motor recovery on hypertensive putaminal hematoma (HPH) with 30 mL or more has been made between conventional treatment and decompressive craniectomy (DC) combined with electroacupuncture (EA). This study aims to examine whether transsylvian-transinsular approach (TTA) to HPH evacuation, DC, and EA have additional value to post-cerebral hemorrhage motor rehabilitation. One hundred twenty patients with HPH of 30-mL volume or greater, who were admitted within 6 hours after ictus, were included in this study. Of the 120 patients, 80 were operated on for hematoma evacuation DC through TTA. The postoperative patients were divided into combined therapy group (CTG) and operation with exercises group (OEG). Combined therapy group (n = 40) was treated with EA, functional exercises from 1 to 3 days after hematoma evacuation DC through TTA, twice each day, and OEG (n = 40) accepted only the same operation and functional exercises. Another 40 patients were classified as functional exercises group to be treated conservatively and with functional exercises only after their relatives declined authorization for surgery and EA. The habilitation effects were assessed by blinded assessors at weeks 0 and 8. Outcome measures included Fugl-Meyer assessment, Barthel Index, and Functional Independence Measure. The statistical difference on the motor recovery was considerable (P < 0.05) between CTG and OEG. Significant differences were observed between CTG and physical therapy group (P < 0.01), and we also found statistical difference (P < 0.05) between OEG and functional exercises group. Surgically treated patients received significantly better motor recovery than did the conservatively treated patients. Microsurgical treatment via TTA of HPH and postoperative EA at an early stage result in improved outcome of motor recovery. Transsylvian-transinsular approach for HPH operation and postoperative EA at an early stage are advocated.

  20. Chaotic Attractor Crisis and Climate Sensitivity: a Transfer Operator Approach

    NASA Astrophysics Data System (ADS)

    Tantet, A.; Lucarini, V.; Lunkeit, F.; Dijkstra, H. A.

    2015-12-01

    The rough response to a smooth parameter change of some non-chaotic climate models, such as the warm to snowball-Earth transition in energy balance models due to the ice-albedo feedback, can be studied in the framework of bifurcation theory, in particular by analysing the Lyapunov spectrum of fixed points or periodic orbits. However, bifurcation theory is of little help to study the destruction of a chaotic attractor which can occur in high-dimensional General Circulation Models (GCM). Yet, one would expect critical slowing down to occur before the crisis, since, as the system becomes susceptible to the physical instability mechanism responsible for the crisis, it turns out to be less and less resilient to exogenous perturbations and to spontaneous fluctuations due to other types of instabilities on the attractor. The statistical physics framework, extended to nonequilibrium systems, is particularly well suited for the study of global properties of chaotic and stochastic systems. In particular, the semigroup of transfer operators governs the evolution of distributions in phase space and its spectrum characterises both the relaxation rate of distributions to a statistical steady-state and the stability of this steady-state to perturbations. If critical slowing down indeed occurs in the approach to an attractor crisis, the gap in the spectrum of the semigroup of transfer operators is expected to shrink. We show that the chaotic attractor crisis due to the ice-albedo feedback and resulting in a transition from a warm to a snowball-Earth in the Planet Simulator (PlaSim), a GCM of intermediate complexity, is associated with critical slowing down, as observed by the slower decay of correlations before the crisis (cf. left panel). In addition, we demonstrate that this critical slowing down can be traced back to the shrinkage of the gap between the leading eigenvalues of coarse-grained approximations of the transfer operators and that these eigenvalues capture the

  1. A Simulation Based Approach for Contingency Planning for Aircraft Turnaround Operation System Activities in Airline Hubs

    NASA Technical Reports Server (NTRS)

    Adeleye, Sanya; Chung, Christopher

    2006-01-01

    Commercial aircraft undergo a significant number of maintenance and logistical activities during the turnaround operation at the departure gate. By analyzing the sequencing of these activities, more effective turnaround contingency plans may be developed for logistical and maintenance disruptions. Turnaround contingency plans are particularly important as any kind of delay in a hub based system may cascade into further delays with subsequent connections. The contingency sequencing of the maintenance and logistical turnaround activities were analyzed using a combined network and computer simulation modeling approach. Experimental analysis of both current and alternative policies provides a framework to aid in more effective tactical decision making.

  2. Structural approaches for prevention of sexually transmitted HIV in general populations: definitions and an operational approach.

    PubMed

    Parkhurst, Justin O

    2014-01-01

    Although biomedical HIV prevention efforts have seen a number of recent promising developments, behavioural interventions have often been described as failing. However, clear lessons have been identified from past efforts, including the need to address influential social, economic and legal structures; to tailor efforts to local contexts; and to address multiple influencing factors in combination. Despite these insights, there remains a pervasive strategy to try to achieve sexual behaviour change through single, decontextualized, interventions or sets of activities. With current calls for structural approaches to HIV as part of combination HIV prevention, though, there is a unique opportunity to define a structural approach to HIV prevention as one which moves beyond these past limitations and better incorporates our knowledge of the social world and the lessons from past efforts. A range of interlinked concepts require delineation and definition within the broad concept of a structural approach to HIV. This includes distinguishing between "structural factors," which can be seen as any number of elements (other than knowledge) which influence risk and vulnerability, and "structural drivers," which should be reserved for situations where an empirically established relationship to a target group is known. Operationalizing structural approaches similarly can take different paths, either working to alter structural drivers or alternatively working to build individual and community resilience to infection. A "structural diagnostic approach" is further defined as the process one undertakes to develop structural intervention strategies tailored to target groups. For three decades, the HIV prevention community has struggled to reduce the spread of HIV through sexual risk behaviours with limited success, but equally with limited engagement with the lessons that have been learned about the social realities shaping patterns of sexual practices. Future HIV prevention efforts

  3. A Combined Approach to Measure Micropollutant Behaviour during Riverbank Filtration

    NASA Astrophysics Data System (ADS)

    van Driezum, Inge; Saracevic, Ernis; Derx, Julia; Kirschner, Alexander; Sommer, Regina; Farnleitner, Andreas; Blaschke, Alfred Paul

    2016-04-01

    Riverbank filtration (RBF) systems are widely used as natural treatment process. The advantages of RBF over surface water abstraction are the elimination of for example suspended solids, biodegradable compounds (like specific micropollutants), bacteria and viruses (Hiscock and Grischek, 2002). However, in contrast to its importance, remarkably less is known on the respective external (e.g. industrial or municipal sewage) and the internal (e.g. wildlife and agricultural influence) sources of contaminants, the environmental availability and fate of the various hazardous substances, and its potential transport during soil and aquifer passage. The goal of this study is to get an insight in the behaviour of various micropollutants and microbial indicators during riverbank filtration. Field measurements were combined with numerical modelling approaches. The study area comprises an alluvial backwater and floodplain area downstream of Vienna. The river is highly dynamic, with discharges ranging from 900 m3/s during low flow to 11000 m3/s during flood events. Samples were taken in several monitoring wells along a transect extending from the river towards a backwater river in the floodplain. Three of the piezometers were situated in the first 20 meters away from the river in order to obtain information about micropollutant behaviour close to the river. A total of 9 different micropollutants were analysed in grab samples taken under different river flow conditions (n=33). Following enrichment using SPE, analysis was performed using high performance liquid chromatography-tandem mass spectrometry. Faecal indicators (E. coli and enterococci) and bacterial spores were enumerated in sample volumes of 1 L each using cultivation based methods (ISO 16649-1, ISO 7899-2:2000 and ISO 6222). The analysis showed that some compounds, e.g. ibuprofen and diclofenac, were only found in the river. These compounds were already degraded in the first ten meters away from the river. Analysis of

  4. Engineering a Multimission Approach to Navigation Ground Data System Operations

    NASA Technical Reports Server (NTRS)

    Gerasimatos, Dimitrios V.; Attiyah, Ahlam A.

    2012-01-01

    The Mission Design and Navigation (MDNAV) Section at the Jet Propulsion Laboratory (JPL) supports many deep space and earth orbiting missions from formulation to end of mission operations. The requirements of these missions are met with a multimission approach to MDNAV ground data system (GDS) infrastructure capable of being shared and allocated in a seamless and consistent manner across missions. The MDNAV computing infrastructure consists of compute clusters, network attached storage, mission support area facilities, and desktop hardware. The multimission architecture allows these assets, and even personnel, to be leveraged effectively across the project lifecycle and across multiple missions simultaneously. It provides a more robust and capable infrastructure to each mission than might be possible if each constructed its own. It also enables a consistent interface and environment within which teams can conduct all mission analysis and navigation functions including: trajectory design; ephemeris generation; orbit determination; maneuver design; and entry, descent, and landing analysis. The savings of these efficiencies more than offset the costs of increased complexity and other challenges that had to be addressed: configuration management, scheduling conflicts, and competition for resources. This paper examines the benefits of the multimission MDNAV ground data system infrastructure, focusing on the hardware and software architecture. The result is an efficient, robust, scalable MDNAV ground data system capable of supporting more than a dozen active missions at once.

  5. The combined tool approach for face mask removal during on-field conditions.

    PubMed

    Gale, Stephanie D; Decoster, Laura C; Swartz, Erik E

    2008-01-01

    An effective approach to emergency removal of the face mask (FM) from a football helmet should include successful removal of the FM and limitation of both the time required and the movement created during the process. Current recommendations and practice are to use a cutting tool to remove the FM. Researchers recently have suggested an alternate approach that combines the use of a cordless screwdriver and a cutting tool. This combined tool approach has not been studied, and FM removal has not been studied in a practical setting. To investigate the effectiveness and speed of using a combined tool approach to remove the FMs from football helmets during on-field conditions throughout the course of a football season. Randomized multigroup design. Practice field of 1 National Collegiate Athletic Association Division II football college. Eighty-four members of 1 football team. We used a battery-operated screwdriver for FM removal and resorted to using a cutting tool as needed. We tracked FM removal success and failure and trial time and compared results based on helmet characteristics, weather variables, and the seasonal timing of the removal trial. Of the 84 players, 76 were available for data-collection trials. Overall, 98.6% (75/76) of FM removal trials were successful and resulted in a mean removal time of 40.09 +/- 15.1 seconds. We found no differences in FM removal time throughout the course of the season. No differences in effectiveness or trial time were found among helmet characteristics, weather variables, or the timing of the trial. Combining the cordless screwdriver and cutting tool provided a fast and reliable means of on-field FM removal in this Division II setting. Despite the excellent overall result, 1 FM was not removed in a timely manner. Therefore, we recommend that athletic trainers practice helmet removal to be prepared should FM removal fail.

  6. Degradation of 2,4-dichlorophenol using combined approach based on ultrasound, ozone and catalyst.

    PubMed

    Barik, Arati J; Gogate, Parag R

    2017-05-01

    The present work investigates the application of ultrasound and ozone operated individually and in combination with catalyst (ZnO and CuO) for establishing the possible synergistic effects for the degradation of 2,4-dichlorophenol. The dependency of extent of degradation on the operating parameters like temperature (over the range of 30-36°C), initial pH (3-9), catalyst as ZnO (loading of 0.025-0.15g/L) and CuO (loading of 0.02-0.1g/L) and initial concentration of 2,4-DCP (20-50ppm) has been established to maximize the efficacy of ultrasound (US) induced degradation. Using only US, the maximum degradation of 2,4-DCP obtained was 28.85% under optimized conditions of initial concentration as 20ppm, pH of 5 and temperature of 34°C. Study of effect of ozone flow rate for approach of only ozone revealed that maximum degradation was obtained at 400mg/h ozone flow rate. The combined approaches such as US+O3, US+ZnO, US+CuO, O3+ZnO, O3+CuO, US+O3+ZnO and US+O3+CuO have been subsequently investigated under optimized conditions and observed to be more efficient as compared to individual approaches. The maximum extent of degradation for the combined operation of US+O3 (400mg/h)+ZnO (0.1g/L) and US+O3 (400mg/h)+CuO (0.08g/L) has been obtained as 95.66% and 97.03% respectively. The degradation products of 2,4-DCP have been identified using GC-MS analysis and the toxicity analysis has also been performed based on the anti-microbial activity test (agar-well diffusion method) for the different treatment strategies. The present work has conclusively established that the combined approach of US+O3+CuO was the most efficient treatment scheme resulting in near complete degradation of 2,4-DCP with production of less toxic intermediates.

  7. Sustaining Operational Resiliency: A Process Improvement Approach to Security Management

    DTIC Science & Technology

    2006-04-01

    5 2 Operational Resiliency Defined....................................................................6 2.1 What is Resiliency...30 4.3.5 Increasing levels of competency............................................... 30 5 A Process Improvement Framework for...mission.................................. 19 Figure 5 : Foundation for operational resiliency ..................................................... 21

  8. Mathematical Approach to the Evaluation and Planning of Influence Operations

    DTIC Science & Technology

    2007-10-01

    from operations research, market research, psychology , sociology and economics to produce useful tools for the quantitative assessment of influence...specialists from market research, psychology , sociology, and economics. While the focus is on building useful mathematical structures, the intention is to...events involved in Influence Operations are Psychological Operations (PSYOP), military deception, counterintelligence, and public affairs functions

  9. A Combined Geometric Approach for Computational Fluid Dynamics on Dynamic Grids

    NASA Technical Reports Server (NTRS)

    Slater, John W.

    1995-01-01

    A combined geometric approach for computational fluid dynamics is presented for the analysis of unsteady flow about mechanisms in which its components are in moderate relative motion. For a CFD analysis, the total dynamics problem involves the dynamics of the aspects of geometry modeling, grid generation, and flow modeling. The interrelationships between these three aspects allow for a more natural formulation of the problem and the sharing of information which can be advantageous to the computation of the dynamics. The approach is applied to planar geometries with the use of an efficient multi-block, structured grid generation method to compute unsteady, two-dimensional and axisymmetric flow. The applications presented include the computation of the unsteady, inviscid flow about a hinged-flap with flap deflections and a high-speed inlet with centerbody motion as part of the unstart / restart operation.

  10. Combined Simulated Annealing and Genetic Algorithm Approach to Bus Network Design

    NASA Astrophysics Data System (ADS)

    Liu, Li; Olszewski, Piotr; Goh, Pong-Chai

    A new method - combined simulated annealing (SA) and genetic algorithm (GA) approach is proposed to solve the problem of bus route design and frequency setting for a given road network with fixed bus stop locations and fixed travel demand. The method involves two steps: a set of candidate routes is generated first and then the best subset of these routes is selected by the combined SA and GA procedure. SA is the main process to search for a better solution to minimize the total system cost, comprising user and operator costs. GA is used as a sub-process to generate new solutions. Bus demand assignment on two alternative paths is performed at the solution evaluation stage. The method was implemented on four theoretical grid networks of different size and a benchmark network. Several GA operators (crossover and mutation) were utilized and tested for their effectiveness. The results show that the proposed method can efficiently converge to the optimal solution on a small network but computation time increases significantly with network size. The method can also be used for other transport operation management problems.

  11. Noise exposed of the operators of combine harvesters with and without a cab.

    PubMed

    Sümer, Sarp Korkut; Say, Sait M; Ege, Fikri; Sabanci, Alaettin

    2006-11-01

    A considerable number of the combine harvesters in Turkey are rather old and used without cabs resulting in unhealthy working conditions for their operators. Noise is one of the detrimental factors. This study deals with determining and comparing the noise exposed on the operators of the combines with and without a cab used for wheat harvesting in Turkey. The sound pressure levels (dB) at octave band center frequencies (31.5-8000Hz) and the sound levels (dBA) at the ear level of the operators were measured on 37 different combine harvesters with four different makes and different years from 1976 to 2001. Fifteen of the combines were without a cab, another 15 had original cabs while remaining seven combines had cabs mounted on them after manufacturing. The sound pressure levels were in a decreasing trend from the lower frequencies to higher frequencies. This trend was more noticeable for the combines with original cab and with the cab mounted after manufacturing compared to the ones without cab. The use of a cab was more effective in the insulation of the noise at the medium and higher frequencies, which have more bothersome effect compared to the lower frequencies. The sound pressure levels were 75-102dB and 46-89dB at low (31.5-500Hz) and high (500-8000Hz) frequencies for all combines, respectively. The sound pressure levels at the frequency of 4000Hz at which the human ear is most sensitive were 6-17dB lower for the combines with the cabs mounted after manufacturing and 9-28dB lower for the ones with the original cabs compared to the combines without cab. The sound levels were 85-90, 81-83, and 76-81dBA for the combines without cab, with cab mounted after manufacturing, and with original cab, respectively. The study showed that the use of a cab was useful in the insulation of the noise, particularly at higher frequencies. In addition, it protects the operator from the factors having detrimental effects on the working efficiency such as high temperature and dusty

  12. Media Combinations and Learning Styles: A Dual Coding Approach.

    ERIC Educational Resources Information Center

    Beacham, N. A.; Elliott, A. C.; Alty, J. L.; Al-Sharrah, A.

    This paper reports initial results from a study which investigated whether different media combinations could be shown to improve students' understanding of computer-based learning materials and to determine whether student learning style affected student understanding for different media combinations. Three groups of participants were given a…

  13. Dynamic modeling and evaluation of solid oxide fuel cell - combined heat and power system operating strategies

    NASA Astrophysics Data System (ADS)

    Nanaeda, Kimihiro; Mueller, Fabian; Brouwer, Jacob; Samuelsen, Scott

    Operating strategies of solid oxide fuel cell (SOFC) combined heat and power (CHP) systems are developed and evaluated from a utility, and end-user perspective using a fully integrated SOFC-CHP system dynamic model that resolves the physical states, thermal integration and overall efficiency of the system. The model can be modified for any SOFC-CHP system, but the present analysis is applied to a hotel in southern California based on measured electric and heating loads. Analysis indicates that combined heat and power systems can be operated to benefit both the end-users and the utility, providing more efficient electric generation as well as grid ancillary services, namely dispatchable urban power. Design and operating strategies considered in the paper include optimal sizing of the fuel cell, thermal energy storage to dispatch heat, and operating the fuel cell to provide flexible grid power. Analysis results indicate that with a 13.1% average increase in price-of-electricity (POE), the system can provide the grid with a 50% operating range of dispatchable urban power at an overall thermal efficiency of 80%. This grid-support operating mode increases the operational flexibility of the SOFC-CHP system, which may make the technology an important utility asset for accommodating the increased penetration of intermittent renewable power.

  14. The Navy and Combined Operations: A Century of Continuity and Change, 1853-1945.

    DTIC Science & Technology

    1987-08-01

    A195 182 TH4E NAVY AND COMBINED OPERATIONS: A CENURY OF A/ CONTINUITY AND CHANGE 1853-1945(U) ARMY COMBINED ARMS CENTER FORTLEAVENMORTH KS SOVIET...CONTINUITY AND CHANGE ., ~__ 1853-1945 . DTIC ELECTE_ MY3 1.1988 y; *g . t -7 SOVIET s ARMY * STUDIES V ~ 9 * OFFICE IXS~~h~~3UT!ONp iTT~I t; .~ ... ~rp’ 1...CENTURY OF CONTINUITY AND CHANGE , 1853-1945 by DR. JACOB W. KIPP Soviet Army Studies Office U.S. Army Combined Arms Center Fort Leavenworth, Kansas

  15. Post-operative brachial plexus neuropraxia: A less recognised complication of combined plastic and laparoscopic surgeries

    PubMed Central

    Thomas, Jimmy

    2014-01-01

    This presentation is to increase awareness of the potential for brachial plexus injury during prolonged combined plastic surgery procedures. A case of brachial plexus neuropraxia in a 26-year-old obese patient following a prolonged combined plastic surgery procedure was encountered. Nerve palsy due to faulty positioning on the operating table is commonly seen over the elbow and popliteal fossa. However, injury to the brachial plexus has been a recently reported phenomenon due to the increasing number of laparoscopic and robotic procedures. Brachial plexus injury needs to be recognised as a potential complication of prolonged combined plastic surgery. Preventive measures are discussed. PMID:25593443

  16. Post-operative brachial plexus neuropraxia: A less recognised complication of combined plastic and laparoscopic surgeries.

    PubMed

    Thomas, Jimmy

    2014-01-01

    This presentation is to increase awareness of the potential for brachial plexus injury during prolonged combined plastic surgery procedures. A case of brachial plexus neuropraxia in a 26-year-old obese patient following a prolonged combined plastic surgery procedure was encountered. Nerve palsy due to faulty positioning on the operating table is commonly seen over the elbow and popliteal fossa. However, injury to the brachial plexus has been a recently reported phenomenon due to the increasing number of laparoscopic and robotic procedures. Brachial plexus injury needs to be recognised as a potential complication of prolonged combined plastic surgery. Preventive measures are discussed.

  17. [Function of portal pressure during operation on the choice of surgical approaches in portal hypertension].

    PubMed

    Chen, Wei; Luo, Meng; Sun, Yong-wei; Xu, Qing; Zhao, Gang; Hua, Rong; Liu, Wei; Jiang, Chun-hui; Shi, Chang-ying; Wu, Zhi-yong

    2008-11-15

    To investigate the relationship between perioperative free portal pressure (FPP) after devascularization or spleno-renal shunt operation added devascularization and rebleeding or encephalopathy in patients with portal hypertension, and evaluate the relationship between dynamic changes of FPP and surgical approaches. The clinical data of 170 patients with portal hypertension receiving devascularization or devascularization with spleno-renal shunt operation (combination group) from January 2001 to December 2007 were retrospectively analyzed. All patients were divided into three groups: low pressure group [L group, after devascularization FPP 22 mm Hg, n = 60) and combination group (C group, n = 47). There was no significant difference in preoperative Child-Pugh score and pre-operation FPP (P > 0.05) among the three groups. Perioperative FPP, morbidity of rebleeding and encephalopathy were compared with each other. The values of postoperative FPP were (27.1 +/- 1.9) mm Hg, (20.8 +/- 1.8) mm Hg and (21.5 +/- 2.2) mm Hg among the H group, L group and C group respectively. The rebleeding rates were 21.7%, 4.6% and 4.5% among the three groups respectively. All the values in H group were higher than those in L group and C group remarkably. The encephalopathy rate in C group (10.4%) was higher than that in L group (7.0%) or H group (3.3%), but there were no statistical significance (P > 0.05). FPP after splenectomy and devascularization may be a basis of choice of surgical approaches in portal hypertension. The spleno-renal shunt operation should be performed in the patients when FPP is over 22 mm Hg after devascularization.

  18. Nonlinear regularization operators as derived from the micromorphic approach to gradient elasticity, viscoplasticity and damage

    PubMed Central

    2016-01-01

    The construction of regularization operators presented in this work is based on the introduction of strain or damage micromorphic degrees of freedom in addition to the displacement vector and of their gradients into the Helmholtz free energy function of the constitutive material model. The combination of a new balance equation for generalized stresses and of the micromorphic constitutive equations generates the regularization operator. Within the small strain framework, the choice of a quadratic potential w.r.t. the gradient term provides the widely used Helmholtz operator whose regularization properties are well known: smoothing of discontinuities at interfaces and boundary layers in hardening materials, and finite width localization bands in softening materials. The objective is to review and propose nonlinear extensions of micromorphic and strain/damage gradient models along two lines: the first one introducing nonlinear relations between generalized stresses and strains; the second one envisaging several classes of finite deformation model formulations. The generic approach is applicable to a large class of elastoviscoplastic and damage models including anisothermal and multiphysics coupling. Two standard procedures of extension of classical constitutive laws to large strains are combined with the micromorphic approach: additive split of some Lagrangian strain measure or choice of a local objective rotating frame. Three distinct operators are finally derived using the multiplicative decomposition of the deformation gradient. A new feature is that a free energy function depending solely on variables defined in the intermediate isoclinic configuration leads to the existence of additional kinematic hardening induced by the gradient of a scalar micromorphic variable. PMID:27274684

  19. 78 FR 44167 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving No Significant Hazards Considerations Background Pursuant to Section 189a. (2) of the Atomic Energy Act of 1954, as amended (the Act), the...

  20. 77 FR 22808 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving No Significant Hazards Considerations Background Pursuant to Section 189a. (2) of the Atomic Energy Act of 1954, as amended (the Act), the ...

  1. 77 FR 48556 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... COMMISSION Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving... purpose of the adjudicatory filings and would constitute a Fair Use application, participants are...)(i)-(viii). For further details with respect to this amendment action, see the application for...

  2. 49 CFR 393.17 - Lamps and reflectors-combinations in driveaway-towaway operation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and... 49 Transportation 5 2012-10-01 2012-10-01 false Lamps and reflectors-combinations in driveaway...

  3. 49 CFR 393.17 - Lamps and reflectors-combinations in driveaway-towaway operation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and... 49 Transportation 5 2014-10-01 2014-10-01 false Lamps and reflectors-combinations in driveaway...

  4. 77 FR 31655 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving No Significant Hazards Considerations Background Pursuant to Section 189a.(2) of the Atomic Energy Act of 1954, as amended (the Act), the...

  5. 49 CFR 393.17 - Lamps and reflectors-combinations in driveaway-towaway operation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and... identification lamps on the rear. (c) If the towed vehicle in a combination is a mobile structure trailer, it must be equipped in accordance with the following lighting devices. For the purposes of this part...

  6. 49 CFR 393.17 - Lamps and reflectors-combinations in driveaway-towaway operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and... identification lamps on the rear. (c) If the towed vehicle in a combination is a mobile structure trailer, it must be equipped in accordance with the following lighting devices. For the purposes of this part...

  7. 49 CFR 393.17 - Lamps and reflectors-combinations in driveaway-towaway operation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SAFETY REGULATIONS PARTS AND ACCESSORIES NECESSARY FOR SAFE OPERATION Lamps, Reflective Devices, and... identification lamps on the rear. (c) If the towed vehicle in a combination is a mobile structure trailer, it must be equipped in accordance with the following lighting devices. For the purposes of this part...

  8. Linking and Combining Distributed Operations Facilities using NASA's "GMSEC" Systems Architectures

    NASA Technical Reports Server (NTRS)

    Smith, Danford; Grubb, Thomas; Esper, Jaime

    2008-01-01

    NASA's Goddard Mission Services Evolution Center (GMSEC) ground system architecture has been in development since late 2001, has successfully supported eight orbiting satellites and is being applied to many of NASA's future missions. GMSEC can be considered an event-driven service-oriented architecture built around a publish/subscribe message bus middleware. This paper briefly discusses the GMSEC technical approaches which have led to significant cost savings and risk reduction for NASA missions operated at the Goddard Space Flight Center (GSFC). The paper then focuses on the development and operational impacts of extending the architecture across multiple mission operations facilities.

  9. Concept of Operations for Interval Management Arrivals and Approach

    NASA Technical Reports Server (NTRS)

    Hicok, Daniel S.; Barmore, Bryan E.

    2016-01-01

    This paper presents the concept of operations for interval management operations to be deployed in the US National Airspace System (NAS) by the Federal Aviation Administration (FAA) after 2020. The use of interval management operations is described that begin in en route airspace and continue to a termination point inside the arrival terminal area, in a terminal environment that includes other arrival management tools such as arrival metering, Ground-based Interval Management - Spacing (GIM-S), and Terminal Sequencing and Spacing (TSAS). The roles of Air Traffic Controllers and Flight Crews and the ground automation tools that are used by Air Traffic Controllers to enable the primary operation and variations are described.

  10. Combining Formal and Functional Approaches to Topic Structure

    ERIC Educational Resources Information Center

    Zellers, Margaret; Post, Brechtje

    2012-01-01

    Fragmentation between formal and functional approaches to prosodic variation is an ongoing problem in linguistic research. In particular, the frameworks of the Phonetics of Talk-in-Interaction (PTI) and Empirical Phonology (EP) take very different theoretical and methodological approaches to this kind of variation. We argue that it is fruitful to…

  11. Nonunitary and unitary approach to Eigenvalue problem of Boson operators and squeezed coherent states

    NASA Technical Reports Server (NTRS)

    Wunsche, A.

    1993-01-01

    The eigenvalue problem of the operator a + zeta(boson creation operator) is solved for arbitrarily complex zeta by applying a nonunitary operator to the vacuum state. This nonunitary approach is compared with the unitary approach leading for the absolute value of zeta less than 1 to squeezed coherent states.

  12. Combining Campbell Standards and the Realist Evaluation Approach: The Best of Two Worlds?

    ERIC Educational Resources Information Center

    van der Knaap, Leontien M.; Leeuw, Frans L.; Bogaerts, Stefan; Nijssen, Laura T. J.

    2008-01-01

    This article presents an approach to systematic reviews that combines the Campbell Collaboration Crime and Justice standards and the realist notion of contexts-mechanisms-outcomes (CMO) configurations. Both approaches have their advantages and drawbacks, and the authors will make a case for combining both approaches to profit from their advantages…

  13. Combining Campbell Standards and the Realist Evaluation Approach: The Best of Two Worlds?

    ERIC Educational Resources Information Center

    van der Knaap, Leontien M.; Leeuw, Frans L.; Bogaerts, Stefan; Nijssen, Laura T. J.

    2008-01-01

    This article presents an approach to systematic reviews that combines the Campbell Collaboration Crime and Justice standards and the realist notion of contexts-mechanisms-outcomes (CMO) configurations. Both approaches have their advantages and drawbacks, and the authors will make a case for combining both approaches to profit from their advantages…

  14. Newer approaches in topical combination therapy for acne.

    PubMed

    Fu, Lisa W; Vender, Ronald B

    2011-10-01

    Acne vulgaris is a common chronic inflammatory cutaneous disease involving the pilosebaceous unit. Its pathophysiology is multifactorial and complex, including obstruction of the pilosebaceous unit due to increased sebum production, abnormal keratinization, proliferation of Propionibacterium acnes (P. acnes), and inflammation. Topical agents are the most commonly used therapy for acne. First generation topicals mainly consist of single agent retinoids, benzoyl peroxide (BPO) and antibacterials that target comedones, P. acnes, and inflammation. Novel topical therapies include combination products with advanced vehicle formulations that target multiple acne pathophysiologies and offer simplified treatment regimes. For example, the combination of clindamycin and tretinoin in a unique vehicle formulation allows for progressive follicle penetration and decreased irritation, resulting in increased efficacy. Furthermore, adapalene or clindamycin with BPO combinations target comedones, inflammation, and P. acnes synergistically. These newer combination products have the potential to increase both efficacy and patient adherence when compared with single agent treatment.

  15. Extrarenal Transplant Artery Pseudoaneurysm: A Combined Therapeutic Approach

    SciTech Connect

    Poels, Jonathan A. D. Riley, Peter L.

    2008-03-15

    Extrarenal transplant pseudoaneurysms are rare, and treatment usually involves sacrificing of the transplant kidney. We report a case where combined use of a thrombotic agent and covered stents successfully excluded a pseudoaneurysm while preserving renal function.

  16. Behavioral profiling in CCTV cameras by combining multiple subtle suspicious observations of different surveillance operators

    NASA Astrophysics Data System (ADS)

    Bouma, Henri; Vogels, Jack; Aarts, Olav; Kruszynski, Chris; Wijn, Remco; Burghouts, Gertjan

    2013-05-01

    Camera surveillance and recognition of deviant behavior is important for the prevention of criminal incidents. A single observation of subtle deviant behavior of an individual may sometimes be insufficient to merit a follow-up action. Therefore, we propose a method that can combine multiple weak observations to make a strong indication that an intervention is required. We analyze the effectiveness of combining multiple observations/tags of different operators, the effects of the tagging instruction these operators received (many tags for weak signals or few tags for strong signals), and the performance of using a semi-automatic system for combining the different observations. The results show that the method can be used to increase hits (detecting criminals) whilst reducing false alarms (bothering innocent passers-by).

  17. STATISTICS-BASED APPROACH TO WASTEWATER TREATMENT PLANT OPERATIONS

    EPA Science Inventory

    This paper describes work toward development of a convenient decision support system to improve everyday operation and control of the wastewater treatment process. The goal is to help the operator detect problems in the process and select appropriate control actions. The system...

  18. Anabolic and antiresorptive therapy for osteoporosis: combination and sequential approaches.

    PubMed

    Cosman, Felicia

    2014-12-01

    In the recent Bone Key Reports review, it was noted that combinations of anabolic and antiresorptive agents have potential to improve bone density and bone strength more than either agent as monotherapy. Small clinical trials have been performed evaluating combinations of PTH1-34 (TPTD) or PTH1-84 (PTH) with a variety of antiresorptives including hormone/estrogen therapy, raloxifene, alendronate, risedronate, ibandronate, zoledronic acid, and denosumab. Most of the studies evaluate dual-energy X-ray absorptiometry outcomes, and a few trials report volumetric mineral density (BMD) by quantitative computed tomography, followed by finite element modeling to calculate bone strength. None of the studies has been powered to assess differences in fracture incidence between combination therapy and monotherapy. BMD outcomes vary based on the timing of introduction of the anabolic agent (before, during, or after antiresorptive treatment), as well as the specific anabolic and antiresorptive used. Furthermore, effects of combination therapies are site-dependent. The most consistent effect of combining antiresorptive agents with PTH or TPTD is a superior hip BMD outcome compared with TPTD/PTH alone. This is most evident when TPTD/PTH is combined with a bisphosphonate or denosumab. In contrast to findings in the hip, in the majority of studies, there is no benefit to spine BMD with combination therapy vs monotherapy. The 2 exceptions to this are when TPTD is combined with denosumab and when TPTD is given as monotherapy first for 9 months, followed by the addition of alendronate (with continuation administration of TPTD). Based on what we now know, in patients previously treated with bisphosphonates who suffer hip fractures or who have very low or declining hip BMD, strong consideration should be given to starting TPTD and continuing a potent antiresorptive agent (possibly switching to zoledronic acid or denosumab) to improve hip BMD and strength quickly. Furthermore, in

  19. Improving operating room turnover time: a systems based approach.

    PubMed

    Bhatt, Ankeet S; Carlson, Grant W; Deckers, Peter J

    2014-12-01

    Operating room (OR) turnover time (TT) has a broad and significant impact on hospital administrators, providers, staff and patients. Our objective was to identify current problems in TT management and implement a consistent, reproducible process to reduce average TT and process variability. Initial observations of TT were made to document the existing process at a 511 bed, 24 OR, academic medical center. Three control groups, including one consisting of Orthopedic and Vascular Surgery, were used to limit potential confounders such as case acuity/duration and equipment needs. A redesigned process based on observed issues, focusing on a horizontally structured, systems-based approach has three major interventions: developing consistent criteria for OR readiness, utilizing parallel processing for patient and room readiness, and enhancing perioperative communication. Process redesign was implemented in Orthopedics and Vascular Surgery. Comparisons of mean and standard deviation of TT were made using an independent 2-tailed t-test. Using all surgical specialties as controls (n = 237), mean TT (hh:mm:ss) was reduced by 0:20:48 min (95 % CI, 0:10:46-0:30:50), from 0:44:23 to 0:23:25, a 46.9 % reduction. Standard deviation of TT was reduced by 0:10:32 min, from 0:16:24 to 0:05:52 and frequency of TT≥30 min was reduced from 72.5to 11.7 %. P < 0.001 for each. Using Vascular and Orthopedic surgical specialties as controls (n = 13), mean TT was reduced by 0:15:16 min (95 % CI, 0:07:18-0:23:14), from 0:38:51 to 0:23:35, a 39.4 % reduction. Standard deviation of TT reduced by 0:08:47, from 0:14:39 to 0:05:52 and frequency of TT≥30 min reduced from 69.2 to 11.7 %. P < 0.001 for each. Reductions in mean TT present major efficiency, quality improvement, and cost-reduction opportunities. An OR redesign process focusing on parallel processing and enhanced communication resulted in greater than 35 % reduction in TT. A systems-based focus should drive OR TT design.

  20. Innovative treatment approaches for rheumatoid arthritis. Combination therapy.

    PubMed

    Borigini, M J; Paulus, H E

    1995-11-01

    It is accepted that combination DMARD therapy is a useful tool in current rheumatological practice. However, well-designed, large, long-term, controlled clinical trials are needed to determine which combinations, dosage schedules, and sequences of administration are most beneficial and least toxic. Until we develop treatment regimens that reliably induce and sustain acceptable control of disease manifestations in all patients for the rest of their natural lifespan, daily oral prednisone will continue to be a troublesome component of 'bridge' therapy, as it becomes the sole surviving constant in complex regimens whose other components are eventually discontinued because of toxicity, lack of efficacy, or non-compliance. We have often seen patients in whom the replacement of a well-tolerated but presumable ineffective DMARD with another DMARD has led to worsening of disease, when the modest benefits of the discontinued DMARD were lost before the hoped for onset of benefit from its replacement became evident. Since the toxicity of combinations of DMARDs has not appeared to be excessive, one can reasonably add the second DMARD to the first, while carefully monitoring for adverse effects and planning ton continue the combination until increased benefit occurs. Subsequently, if the second DMARD is not tolerated, the partial benefit from the first has not been given up, and a longer duration of treatment with the initial DMARD is sometimes associated with satisfactory improvement. If better control of rheumatoid arthritis is evident after 3-6 months of treatment with the combination of DMARDs, one must still decide whether to stop the first DMARD, stop the second, or continue with the combination. In the absence of major toxicity, we are most likely to choose to continue the combination if the patient has had a good response, thus inadvertently embarking on prolonged combined DMARD therapy (Paulus, 1990). Of course, other drugs besides those discussed above are available

  1. The Rendez-vous technique for treatment of caesarean scar defects: a novel combined endoscopic approach.

    PubMed

    Nirgianakis, Konstantinos; Oehler, Robert; Mueller, Michael

    2016-02-01

    A caesarean scar defect is a late complication of caesarean birth with a wide range of prevalence between 56 and 84% depending on which diagnostic tool and which definition is used. The referred symptoms which include postmenstrual spotting and infertility are fortunately rare. Moreover, severe complications such as caesarean scar pregnancy and uterine rupture in the following pregnancy may occur. Given the increasing incidence of caesarean births, the potential morbidity associated with caesarean scars is likely to become more important. Recently, a few repair techniques were described in the literature including the hysteroscopic resection of scarred tissue or the laparoscopic repair with or without robotic assistance. Between June 2009 and February 2014, 21 women with caesarean scar defects were operated with the Rendez-vous technique, a minimally invasive surgery combining the laparoscopic and hysteroscopic approach. Data were retrospectively collected. The indications for this surgery included secondary infertility, previous caesarean scar pregnancy, recurrent miscarriage and postmenstrual spotting. Prior to operation, a transvaginal ultrasound was performed to examine the uterine wall defect. The patient characteristics are provided in Table 1. In all cases, the operation was successfully completed laparoscopically. The median operation time was 125 min. One case was complicated by recurrence of the scar defect 6 weeks after the operation. No other intra- or post-operative complications were observed, and the median in-patient stay was 3 days. The benefits of the technique include the feasibility and safety of the procedure, the "Halloween sign" (Fig. 1) which indicates the exact extent and localization of the scar defect and the immediate assessment of repair through the hysteroscopy at the end of the surgery. However, before further studies evaluate the efficacy of this method, the routine repair of caesarean scar defects cannot be recommended. A video of

  2. Systems Thinking for Integrated Operations: Introducing a Systemic Approach to Operational Art for Disaster Relief

    DTIC Science & Technology

    2006-05-25

    and mechanisms for national-level policy and operational coordination for domestic incident management. • Does not alter or impede the ability of... operational art provides a linkage between the often abstract and ambiguous national-level policy goals and the “relatively mechanical , straightforward, and...author of In Pursuit of Military Excellence: The Evolution of Operational Theory. The difference between tactical-level problem solving and operational

  3. Structural approaches for prevention of sexually transmitted HIV in general populations: definitions and an operational approach

    PubMed Central

    Parkhurst, Justin O

    2014-01-01

    Introduction Although biomedical HIV prevention efforts have seen a number of recent promising developments, behavioural interventions have often been described as failing. However, clear lessons have been identified from past efforts, including the need to address influential social, economic and legal structures; to tailor efforts to local contexts; and to address multiple influencing factors in combination. Despite these insights, there remains a pervasive strategy to try to achieve sexual behaviour change through single, decontextualized, interventions or sets of activities. With current calls for structural approaches to HIV as part of combination HIV prevention, though, there is a unique opportunity to define a structural approach to HIV prevention as one which moves beyond these past limitations and better incorporates our knowledge of the social world and the lessons from past efforts. Discussion A range of interlinked concepts require delineation and definition within the broad concept of a structural approach to HIV. This includes distinguishing between “structural factors,” which can be seen as any number of elements (other than knowledge) which influence risk and vulnerability, and “structural drivers,” which should be reserved for situations where an empirically established relationship to a target group is known. Operationalizing structural approaches similarly can take different paths, either working to alter structural drivers or alternatively working to build individual and community resilience to infection. A “structural diagnostic approach” is further defined as the process one undertakes to develop structural intervention strategies tailored to target groups. Conclusions For three decades, the HIV prevention community has struggled to reduce the spread of HIV through sexual risk behaviours with limited success, but equally with limited engagement with the lessons that have been learned about the social realities shaping patterns of

  4. A suprapubic retroperitoneal operative approach to solitary paravaginal tumors.

    PubMed

    Cowles, T; Schwartz, P E

    1987-03-01

    Five cases of paravaginal tumors including a neurolemmoma, neurofibroma, lipoma, and desmoid tumors are presented. These tumors were approached through a modified Cherney incision. The rectus muscle was removed from the pubic symphysis and the pubococcygeus muscle was divided. This approach allowed good visualization of the paravaginal space, reasonable blood loss, and avoidance of entry into the peritoneal cavity. Although paravaginal tumors are rare, gynecologic surgeons should be aware of the suprapubic approach to the paravaginal space.

  5. Satellite Ground Operations Automation: Lessons Learned and Future Approaches

    NASA Technical Reports Server (NTRS)

    Catena, John; Frank, Lou; Saylor, Rick; Weikel, Craig; Obenschain, Arthur F. (Technical Monitor)

    2001-01-01

    Reducing spacecraft ground system operations costs is a major goal in all missions. The Fast Auroral Snapshot (FAST) flight operations team at the NASA/Goddard Spacecraft Flight Center developed in-house scripts and procedures to automate monitoring of critical spacecraft functions. The initial staffing profile of 16x7 was reduced first to 8x5 and then to 'lights out'. Operations functions became an offline review of system performance and the generation of future science plans for subsequent upload to the spacecraft. Lessons learned will be applied to the challenging Triana mission, where 24x7 contact with the spacecraft will be necessary at all times.

  6. Space Station - An integrated approach to operational logistics support

    NASA Technical Reports Server (NTRS)

    Hosmer, G. J.

    1986-01-01

    Development of an efficient and cost effective operational logistics system for the Space Station will require logistics planning early in the program's design and development phase. This paper will focus on Integrated Logistics Support (ILS) Program techniques and their application to the Space Station program design, production and deployment phases to assure the development of an effective and cost efficient operational logistics system. The paper will provide the methodology and time-phased programmatic steps required to establish a Space Station ILS Program that will provide an operational logistics system based on planned Space Station program logistics support.

  7. 77 FR 29701 - Impact of Construction (Under a Combined License) of New Nuclear Power Plant Units on Operating...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-18

    ... a Combined License) of New Nuclear Power Plant Units on Operating Units at Multi-Unit Sites AGENCY... a COL intending to construct and operate new nuclear power plants (NPPs) on multi-unit sites to... Impacts of Construction (under a Combined License) of New Nuclear Power Plants on Operating Units at...

  8. High Power Spatial Combiners: Tile and Tray Approaches

    DTIC Science & Technology

    2001-01-01

    GHz with a 3-dB bandwidth of 1.8 GHz or 4.5%. The maximum saturated output power was 670 mW at 40 GHz with a peak power -added efficiency ... power added efficiency of 12%, which was the highest recorded output power of a spatial power combining amplifier at this frequency. The small-signal...5 dB of gain at 9.8 GHz with a 3-dB bandwidth of 400 MHz. The 3-dB compression power was 17.7 dBm with a power combining

  9. A Combined Arms Approach to Defending Army Networks

    DTIC Science & Technology

    2012-01-01

    CEMA is to gain an advantage, protect the...best to accom- plish CEMA integration for the long term. Current plans envision CEMA integrated with- in the operations process via the Cyber-Electro...situational awareness and con- tinually assesses progress toward desired conditions. The first demonstration of the CEMA concept will occur

  10. Improved genetic algorithm for the protein folding problem by use of a Cartesian combination operator.

    PubMed

    Rabow, A A; Scheraga, H A

    1996-09-01

    We have devised a Cartesian combination operator and coding scheme for improving the performance of genetic algorithms applied to the protein folding problem. The genetic coding consists of the C alpha Cartesian coordinates of the protein chain. The recombination of the genes of the parents is accomplished by: (1) a rigid superposition of one parent chain on the other, to make the relation of Cartesian coordinates meaningful, then, (2) the chains of the children are formed through a linear combination of the coordinates of their parents. The children produced with this Cartesian combination operator scheme have similar topology and retain the long-range contacts of their parents. The new scheme is significantly more efficient than the standard genetic algorithm methods for locating low-energy conformations of proteins. The considerable superiority of genetic algorithms over Monte Carlo optimization methods is also demonstrated. We have also devised a new dynamic programming lattice fitting procedure for use with the Cartesian combination operator method. The procedure finds excellent fits of real-space chains to the lattice while satisfying bond-length, bond-angle, and overlap constraints.

  11. Soluble collagen approach to a combination tannage mechanism

    USDA-ARS?s Scientific Manuscript database

    Although complex salts of Cr(III) sulfate are currently the most effective tanning agents, salts of other metals, including aluminum, have been used either alone or in combination with vegetable tannins or other organic chemicals. In the present study, the interactions of metallic sulfates, and cond...

  12. Smoking Intervention: A Combination Therapy Approach to Cessation.

    ERIC Educational Resources Information Center

    Glover, Penny Neathery

    1993-01-01

    Provides an overview of the Start SMART smoking cessation program which combines nicotine withdrawal therapy with behavior modification. The Start SMART program provides seven, intensive one-hour group sessions that are shown to be a most effective intervention with a specific population--motivated, yet highly dependent smokers. (GLR)

  13. Management of Combined Natural Risks - A New Approach: Keynote Address

    NASA Astrophysics Data System (ADS)

    Hanisch, Jörg

    A new attempt is made to illustrate and to quantify the relationships of individual natural hazards, their combinations and the human vulnerability to natural hazards. During many catastrophic events, combinations of different natural events aggravate their occurrence substantially. Earthquakes are frequently associated with heavy landsliding (El Salvador 2001) and heavy rainstorms are able to trigger fast running debris flows and not only floods (like during the Mitch disaster in Central America in 1998). That signifies that natural hazard maps should show the combinations of different hazards and their genetic relationships. To put into effect this, first, the individual hazards have to be assessed and presented in hazard zones (0 to 3). Then these hazards zones will be overlain using GIS techniques. In this way, e.g., an earthquake-prone area which coincides with an area susceptible to landslides (ranking 0 to 3 as well) can show hazard concentrations of up to a value of 6, simply adding the individual hazard zones. To get the result of the corresponding risk zones, the vulnerability maps of human settlements and infra-structure have to be overlain on the maps of these combinations of natural hazards.

  14. Soluble collagen approach to a combination tannage mechanism

    USDA-ARS?s Scientific Manuscript database

    Although complex salts of Cr(III) sulfate are currently the most effective tanning agents, salts of other metals, including aluminum, have been used either alone or in combination with vegetable tannins or other organic chemicals. In the present study, the interactions of aluminum sulfate, and quebr...

  15. [Median nerve constrictive operation combined with tendon transfer to treat brain paralysis convulsive deformity of hand].

    PubMed

    Ma, Shanjun; Zhou, Tianjian

    2014-05-01

    To evaluate the effectiveness of the median nerve constrictive operation combined with tendon transfer to treat the brain paralysis convulsive deformity of the hand. The clinical data from 21 cases with brain paralysis convulsive deformity of the hand were analyzed retrospectively between August 2009 and April 2012. Of them, there were 13 males and 8 females with an average age of 15 years (range, 10-29 years). The causes of the convulsive cerebral palsy included preterm deliveries in 11 cases, hypoxia asphyxia in 7, traumatic brain injury in 2, and encephalitis sequela in 1. The disease duration was 2-26 years (mean, 10.6 years). All the 21 patients had cock waists, crooking fingers, and contracture of adductors pollicis, 12 had the forearm pronation deformity. According to Ashworth criteria, there were 2 cases at level I, 5 cases at level II, 8 cases at level III, 4 cases at level IV, and 2 cases at level V. All patients had no intelligence disturbances. The forearm X-ray film showed no bone architectural changes before operation. The contraction of muscle and innervation was analyzed before operation. The median nerve constrictive operation combined with tendon transfer was performed. The functional activities and deformity improvement were evaluated during follow-up. After operation, all the patients' incision healed by first intension, without muscle atrophy and ischemic spasm. All the 21 cases were followed up 1.5-4.5 years (mean, 2.3 years). No superficial sensory loss occurred. The effectiveness was excellent in 13 cases, good in 6 cases, and poor in 2 cases, with an excellent and good rate of 90.4% at last follow-up. The median nerve constrictive operation combined with tendon transfer to treat brain paralysis convulsive deformity of the hand can remove and prevent the recurrence of spasm, achieve the orthopedic goals, to assure the restoration of motor function and the improvement of the life quality.

  16. Mineral image enhancement based on sequential combination of toggle and top-hat based contrast operator.

    PubMed

    Bai, Xiangzhi

    2013-01-01

    Enhancing mineral image especially making mineral image details clear is very useful for mineral analysis. To effectively enhance mineral image, an algorithm based on the toggle contrast operator and top-hat based contrast operator is proposed in this paper. Sequentially combining the toggle contrast operator and top-hat based contrast operator could be used to identify image features especially the image details. So, appropriately exacting the identified image features by the sequentially combined toggle and top-hat based contrast operator is important for mineral image enhancement, which is analyzed firstly in this paper. After that, the multi-scale extension of feature extraction is given and used to construct the final features for mineral image enhancement. By importing the final extracted image features into the original mineral image through contrast enlargement, the original mineral image is well enhanced and the mineral image details are very clear. Experimental results on different types of mineral images verified the effective performance of the proposed algorithm. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Operative and diagnostic hysteroscopy: A novel learning model combining new animal models and virtual reality simulation.

    PubMed

    Bassil, Alfred; Rubod, Chrystèle; Borghesi, Yves; Kerbage, Yohan; Schreiber, Elie Servan; Azaïs, Henri; Garabedian, Charles

    2017-04-01

    Hysteroscopy is one of the most common gynaecological procedure. Training for diagnostic and operative hysteroscopy can be achieved through numerous previously described models like animal models or virtual reality simulation. We present our novel combined model associating virtual reality and bovine uteruses and bladders. End year residents in obstetrics and gynaecology attended a full day workshop. The workshop was divided in theoretical courses from senior surgeons and hands-on training in operative hysteroscopy and virtual reality Essure(®) procedures using the EssureSim™ and Pelvicsim™ simulators with multiple scenarios. Theoretical and operative knowledge was evaluated before and after the workshop and General Points Averages (GPAs) were calculated and compared using a Student's T test. GPAs were significantly higher after the workshop was completed. The biggest difference was observed in operative knowledge (0,28 GPA before workshop versus 0,55 after workshop, p<0,05). All of the 25 residents having completed the workshop applauded the realism an efficiency of this type of training. The force feedback allowed by the cattle uteruses gives the residents the possibility to manage thickness of resection as in real time surgery. Furthermore, the two-horned bovine uteruses allowed to reproduce septa resection in conditions close to human surgery CONCLUSION: Teaching operative and diagnostic hysteroscopy is essential. Managing this training through a full day workshop using a combined animal model and virtual reality simulation is an efficient model not described before. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Formalized Conflicts Detection Based on the Analysis of Multiple Emails: An Approach Combining Statistics and Ontologies

    NASA Astrophysics Data System (ADS)

    Zakaria, Chahnez; Curé, Olivier; Salzano, Gabriella; Smaïli, Kamel

    In Computer Supported Cooperative Work (CSCW), it is crucial for project leaders to detect conflicting situations as early as possible. Generally, this task is performed manually by studying a set of documents exchanged between team members. In this paper, we propose a full-fledged automatic solution that identifies documents, subjects and actors involved in relational conflicts. Our approach detects conflicts in emails, probably the most popular type of documents in CSCW, but the methods used can handle other text-based documents. These methods rely on the combination of statistical and ontological operations. The proposed solution is decomposed in several steps: (i) we enrich a simple negative emotion ontology with terms occuring in the corpus of emails, (ii) we categorize each conflicting email according to the concepts of this ontology and (iii) we identify emails, subjects and team members involved in conflicting emails using possibilistic description logic and a set of proposed measures. Each of these steps are evaluated and validated on concrete examples. Moreover, this approach's framework is generic and can be easily adapted to domains other than conflicts, e.g. security issues, and extended with operations making use of our proposed set of measures.

  19. Combining Cognitive and Interactive Approaches to Lingua Receptiva

    ERIC Educational Resources Information Center

    Bahtina, Daria; ten Thije, Jan D.; Wijnen, Frank

    2013-01-01

    This study takes an experimental approach to "lingua receptiva" (LaRa), a communication mode in which interlocutors each use their own--different--native language. In contrast to previous work on LaRa, this study investigates the phenomenon in genetically unrelated languages. Native speakers of Estonian and Russian were engaged in a…

  20. Approaches to Combining Quantitative and Qualitative Social Support Research.

    ERIC Educational Resources Information Center

    Ingersoll, Berit

    Social scientists tend to adopt either a qualitative or a quantitative perspective in research on social support. As single methods, each perspective has unique distinctions, limitations, and trade-offs. These approaches are based on differing epistemological assumptions. Qualitative research attempts to understand human behavior from the…

  1. Combining Cognitive and Interactive Approaches to Lingua Receptiva

    ERIC Educational Resources Information Center

    Bahtina, Daria; ten Thije, Jan D.; Wijnen, Frank

    2013-01-01

    This study takes an experimental approach to "lingua receptiva" (LaRa), a communication mode in which interlocutors each use their own--different--native language. In contrast to previous work on LaRa, this study investigates the phenomenon in genetically unrelated languages. Native speakers of Estonian and Russian were engaged in a…

  2. Agonist-antagonist combinations in opioid dependence: a translational approach

    PubMed Central

    Mannelli, P.

    2011-01-01

    Summary The potential therapeutic benefits of co-administering opiate agonist and antagonist agents remain largely to be investigated. This paper focuses on the mechanisms of very low doses of naltrexone that help modulate the effects of methadone withdrawal and review pharmacological properties of the buprenorphine/naltrexone combination that support its clinical investigation. The bench-to-bedside development of the very low dose naltrexone treatment can serve as a translational paradigm to investigate and treat drug addiction. Further research on putative mechanisms elicited by the use of opioid agonist-antagonist combinations may lead to effective pharmacological alternatives to the gold standard methadone treatment, also useful for the management of the abuse of non opioid drugs and alcohol. PMID:22448305

  3. Combination Approaches to Combat Multi-Drug Resistant Bacteria

    PubMed Central

    Worthington, Roberta J.; Melander, Christian

    2013-01-01

    The increasing prevalence of infections caused by multi-drug resistant bacteria is a global health problem that is exacerbated by the dearth of novel classes of antibiotics entering the clinic over the past 40 years. Herein we describe recent developments toward combination therapies for the treatment of multi-drug resistant bacterial infections. These efforts include antibiotic-antibiotic combinations, and the development of adjuvants that either directly target resistance mechanisms such as the inhibition of β-lactamase enzymes, or indirectly target resistance by interfering with bacterial signaling pathways such as two-component systems. We also discuss screening of libraries of previously approved drugs to identify non-obvious antimicrobial adjuvants. PMID:23333434

  4. Combined Biology and Bioinformatics Approaches to Breast Cancer

    DTIC Science & Technology

    2006-04-01

    AD_________________ Award Number: W81XWH-04- 1 -0483 TITLE: Combined Biology and Bioinformatics...reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching...ABOVE ADDRESS. 1 . REPORT DATE 01-04-2006 2. REPORT TYPE Annual 3. DATES COVERED 1 Apr 2005 – 31 Mar 2006 4. TITLE AND SUBTITLE 5a. CONTRACT

  5. [First fixed dose combination perindopril arginine-indapamide-amlodipine: new approach in combination therapy in hypertension].

    PubMed

    Jr, Jiří Widimský

    2014-09-01

    Use of fixed combination of antihypertensive drugs clearly improves compliance to the pharmacological therapy, control of hypertension and prognosis. Based on the current guidelines triple antihypertensive therapy with RAS-blocker, calcium channel blocker (CCB) and diuretic represents the standard and best option. The article introduces first and innovative fixed triple combination of perindopril arginine + indapamide + amlodipine (Triplixam®). This type of therapy is suitable for patients already treated with free combinations of three antihypertensive drugs or in those hypertensives with uncontrolled hypertension on two antihypertensive molecules (approx. 60% of all hypertensive population). Fixed combination of perindopril arginine + indapamid + amlodipin is indicated also in severe hypertension (approx. 30% of pts). Large clinical data from various morbidity-mortality studies related to each of these substances are discussed as well as basic pharmacological characteristics. Based on the results from ADVANCE-CCB study combination of perindopril arginine + indapamide + CCB decreases total mortality in hypertension by 28%. Another discussed study-PIANIST confirmed significant antihypertensive effect of Triplixam® on large sample of patients with various stages of hypertension. Triplixam® in addition to that has very good tolerance with low side effects profile, flexibility of the dosages and large body of evidence of positive impact on prognosis of hypertensive patients. Use of Triplixam® may improve control of hypertension in the Czech Republic.Key words: amlodipine - fixed combination - hypertension - indapamide - perindopril arginine - therapy.

  6. Endoscope-assisted endonasal versus supraorbital keyhole resection of olfactory groove meningiomas: comparison and combination of 2 minimally invasive approaches.

    PubMed

    Banu, Matei A; Mehta, Alpesh; Ottenhausen, Malte; Fraser, Justin F; Patel, Kunal S; Szentirmai, Oszkar; Anand, Vijay K; Tsiouris, Apostolos J; Schwartz, Theodore H

    2016-03-01

    Although the endonasal endoscopic approach has been applied to remove olfactory groove meningiomas, controversy exists regarding the efficacy and safety of this approach compared with more traditional transcranial approaches. The endonasal endoscopic approach was compared with the supraorbital (eyebrow) keyhole technique, as well as a combined "above-and-below" approach, to evaluate the relative merits of each approach in different situations. Nineteen cases were reviewed and divided according to operative technique into 3 different groups: purely endonasal (6 cases); supraorbital eyebrow (microscopic with endoscopic assistance; 7 cases); and combined endonasal endoscopic with either the bicoronal or eyebrow microscopic approach (6 cases). Resection was judged on postoperative MRI using volumetric analysis. Tumors were assessed based on the Mohr radiological classification and the presence of the lion's mane sign. The mean age at surgery was 61.4 years. The mean tumor volume was 19.6 cm(3) in the endonasal group, 33.5 cm(3) in the supraorbital group, and 37.8 cm(3) in the combined group. Significant frontal lobe edema was identified in 10 cases (52.6%). The majority of tumors were either Mohr Grade II (moderate) (42.1%) or Grade III (large) (47.4%). Gross-total resection was achieved in 50% of the endonasal cases, 100% of the supraorbital eyebrow cases with endoscopic assistance, and 66.7% of the combined cases. The extent of resection was 87.8% for the endonasal cases, 100% for the supraorbital eyebrow cases, and 98.9% for the combined cases. Postoperative anosmia occurred in 100% of the endonasal and combined cases and only 57.1% of the supraorbital eyebrow cases. Excluding anosmia, permanent complications occurred in 83.3% of the cases in the endoscopic group, 0% of the cases in the supraorbital eyebrow group, and 16.7% of cases in the combined group (p = 0.017). There were 3 tumor recurrences: 2 in the endonasal group and 1 in the combined group. The

  7. Narrow linewidth operation of a spectral beam combined diode laser bar.

    PubMed

    Zhu, Zhanda; Jiang, Menghua; Cheng, Siqi; Hui, Yongling; Lei, Hong; Li, Qiang

    2016-04-20

    Our experiment is expected to provide an approach for realizing ultranarrow linewidth for a spectral beam combined diode laser bar. The beams of a diode laser bar are combined in a fast axis after a beam transformation system. With the help of relay optics and a transform lens with a long focal length of 1.5 m, the whole wavelength of a spectral combined laser bar can be narrowed down to 0.48 nm from more than 10 nm. We have achieved 56.7 W cw from a 19-element single bar with an M2 of 1.4  (in horizontal direction)×11.6  (in vertical direction). These parameters are good evidence that all the beams from the diode laser bar are combined together to increase the brightness.

  8. Guerrilla Counterintelligence: Insurgent Approaches to Neutralizing Adversary Intelligence Operations

    DTIC Science & Technology

    2009-01-01

    are replete with examples suggest- ing that even the most primitive political and social organizations had developed approaches to protect their...are anarchists of various stripes with global agendas (e.g., free trade), fringe environmental groups, and public/ social policy pro- testers whose...bodies attempting to dismantle or control them. A … even the most primitive political and social organizations had developed approaches to protect their

  9. A combined field and laboratory design for assessing the impact of night shift work on police officer operational performance.

    PubMed

    Waggoner, Lauren B; Grant, Devon A; Van Dongen, Hans P A; Belenky, Gregory; Vila, Bryan

    2012-11-01

    This study assessed the utility of a combined field and laboratory research design for measuring the impact of consecutive night shift work on the sleepiness, vigilance, and driving performance of police patrol officers. For police patrol officers working their normal night shift duty cycles, simulated driving performance and psychomotor vigilance were measured in a laboratory on two separate occasions: in the morning after the last of five consecutive 10.7-h night shifts, and at the same time in the morning after three consecutive days off duty. Order of participation in conditions was randomized among subjects. Subjects experienced manipulation of sleep schedules due to working night shifts in a real operational environment, but performance testing was conducted under controlled laboratory conditions. N = 29 active-duty police patrol officers (27 male, 2 female; age 37.1 ± 6.3 years) working night shift schedules participated in this study. Simulated driving performance, psychomotor vigilance, and subjective sleepiness were significantly degraded following 5 consecutive night shifts as compared to 3 consecutive days off duty, indicating that active-duty police officers are susceptible to performance degradation as a consequence of working nights. This combined field and laboratory research design succeeded in bridging the gap between the realism of the operational environment and the control of laboratory performance testing, demonstrating that this is a useful approach for addressing the relationship between shift work induced fatigue and critical operational task performance.

  10. A holistic approach towards optimal planning of hybrid renewable energy systems: Combining hydroelectric and wind energy

    NASA Astrophysics Data System (ADS)

    Dimas, Panagiotis; Bouziotas, Dimitris; Efstratiadis, Andreas; Koutsoyiannis, Demetris

    2014-05-01

    Hydropower with pumped storage is a proven technology with very high efficiency that offers a unique large-scale energy buffer. Energy storage is employed by pumping water upstream to take advantage of the excess of produced energy (e.g. during night) and next retrieving this water to generate hydro-power during demand peaks. Excess energy occurs due to other renewables (wind, solar) whose power fluctuates in an uncontrollable manner. By integrating these with hydroelectric plants with pumped storage facilities we can form autonomous hybrid renewable energy systems. The optimal planning and management thereof requires a holistic approach, where uncertainty is properly represented. In this context, a novel framework is proposed, based on stochastic simulation and optimization. This is tested in an existing hydrosystem of Greece, considering its combined operation with a hypothetical wind power system, for which we seek the optimal design to ensure the most beneficial performance of the overall scheme.

  11. An overview of liquid phase microextraction approaches combined with UV-Vis spectrophotometry.

    PubMed

    Dehghani Mohammad Abadi, Malihe; Ashraf, Narges; Chamsaz, Mahmoud; Shemirani, Farzaneh

    2012-09-15

    Ultraviolet and visible spectrophotometer has become a popular analytical instrument in the modern day laboratories. However, the low concentrations of many analytes in samples make it difficult to directly measure them by UV-Vis spectrophotometry. This overview focuses on the combinations of microvolume UV-Vis spectrophotometry with miniaturized approaches to sample preparation, namely, single drop microextraction (SDME), dispersive liquid-liquid microextraction (DLLME), cold induced aggregation microextraction (CIAME), in situ solvent formation microextraction (ISSFME), ultrasound assisted emulsification microextraction (USAEME), solidified floating organic drop microextraction (SFODME), and hollow fiber based liquid phase microextraction (HF-LPME) to improve both the selectivity and sensitivity. Integration of these techniques provides unique advantages which include availability, simplicity of operation, low cost, speed, precision and accuracy; hence making them a powerful tool in chemical analysis.

  12. Combining Particle Filters and Consistency-Based Approaches for Monitoring and Diagnosis of Stochastic Hybrid Systems

    NASA Technical Reports Server (NTRS)

    Narasimhan, Sriram; Dearden, Richard; Benazera, Emmanuel

    2004-01-01

    Fault detection and isolation are critical tasks to ensure correct operation of systems. When we consider stochastic hybrid systems, diagnosis algorithms need to track both the discrete mode and the continuous state of the system in the presence of noise. Deterministic techniques like Livingstone cannot deal with the stochasticity in the system and models. Conversely Bayesian belief update techniques such as particle filters may require many computational resources to get a good approximation of the true belief state. In this paper we propose a fault detection and isolation architecture for stochastic hybrid systems that combines look-ahead Rao-Blackwellized Particle Filters (RBPF) with the Livingstone 3 (L3) diagnosis engine. In this approach RBPF is used to track the nominal behavior, a novel n-step prediction scheme is used for fault detection and L3 is used to generate a set of candidates that are consistent with the discrepant observations which then continue to be tracked by the RBPF scheme.

  13. Armageddon’s Lost Lessons: Combined Arms Operations in Allenby’s Palestine Campaign

    DTIC Science & Technology

    2005-02-01

    Unfortunately, the true lessons of Allenby?s campaign were lost for future generations of military officers. Focusing on the culture and romanticism ...Allenby’s campaign were lost for future generations of military officers. Focusing on the culture and romanticism of the horse cavalry, students of the... romanticism of the “last cavalry charge” instead of on the efficacy of combined arms operations, conservative military leaders saw the battle only as an

  14. Combining Exact and Heuristic Approaches for Discrete Optimization

    DTIC Science & Technology

    2009-02-18

    XPRESS . This success has stimulated the need for methodology to solve even much larger problems and the desire to solve problems in real-time. We...problems that cannot be solved to optimalitv using the leading commercial solvers such as CPLEX and XPRESS . These problems are either too large or too...an improved solution is found then Update the global solution end if end while The key to making this approach work is problem dependent. We

  15. Consolidative Technique Otoplasty: Comprehensive Approach in Combining Techniques.

    PubMed

    Temel, Metin

    2016-12-01

    This study aimed to present the long-term results of the consolidative technique otoplasty (CTO). Patient age, sex, duration of follow-up, and how the deformity (bilateral-unilateral) occurred were determined. The kind of anesthesia, duration of surgery, surgical techniques used during the operation were reported, and the preoperative and postoperative distances between the ear and head were measured at four points (SUP: The highest point of the helix; SCA: the concha superior sticking points; ICA: stick point of Concha at the inferior; and lobular). Early- and late-term complications were recorded in the postoperative period. A total of 63 (21M-42FM) patients whose average age of 21:41 ± 8.96 (7-41), 119 ears (Right: 58/Left: 61) were operated on with this technique between 2013 and 2015. Mean follow-up was 18:22 ± 9:42 months. Anterior scoring was performed for three patients; concha resection was performed in 17 patients. Fifty-five patients were operated on as primary otoplasties and eight were secondary otoplasties. When the preoperative and postoperative SUP, SCA, ICA, and lobule measurements for both ears were compared, the postoperative values were found to be significantly decreased (p < 0.001). This technique may be an alternative in the repairs of prominent ears, and it provides an intervention opportunity for all the anatomical structures. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  16. Operating Characteristics of Expander/Compressor Combination for Carbon Dioxide Refrigeration Cycle

    NASA Astrophysics Data System (ADS)

    Fukuta, Mitsuhiro; Yanagisawa, Tadashi; Nakaya, Seiji

    An expander can improve the performance of CO2 refrigeration cycles by recovering a throttling loss. One way to utilize the recovered work is to drive an additional compressor by the expander, and it is effective to use an intercooler between a first-stage compressor and a second-stage compressor. An expander/compressor combination, in which the second-stage compressor is driven by the expander autonomously, is developed and the operating characteristics of the achine are discussed. It is operated at a balance point of mass flow rate and shaft torque between the compressor and the expander, and the balance point can be estimated using performance data of the compressor and expander. Although the expander/compressor combination improves the cycle performance, a heat rejection pressure is not maintained at an optimum pressure under off-design operating conditions. A control that keeps the heat rejection pressure optimum by a pre-expansion or a bypass is effective to obtain good performance of the CO2 refrigeration cycle with the expander/compressor combination.

  17. Keyhole Approach Combined With External Ventricular Drainage for Ruptured, Poor-Grade, Anterior Circulation Cerebral Aneurysms

    PubMed Central

    Zheng, Shu-Fa; Yao, Pei-Sen; Yu, Liang-Hong; Kang, De-Zhi

    2015-01-01

    Abstract Poor-grade ruptured anterior circulation cerebral aneurysms are frequently associated with severe vasospasm and high morbidity rates despite recent remarkable advances in endovascular coiling. Here, we explored the feasibility of keyhole approach combined with external ventricular drainage for ruptured, poor-grade, anterior circulation cerebral aneurysms. We retrospectively assessed the records of 103 patients with ruptured, Hunt and Hess grade IV or V, anterior circulation cerebral aneurysms. The patients were divided into 2 groups (conservative group and surgical group). In surgical group, patients were divided into 2 subgroups according to surgical time (within 24 hours and at 24–48 hours). Clinical outcome was assessed at the 6-month follow-up and categorized according to modified Rankin Scale (mRS) score. Twenty percent of patients (9/44) in conservative group obtained good outcome, while 54% (32/54) in surgical group (P < 0.05). Mortality was 73% in conservative group and 40% in surgical group, respectively. In surgical group, age, Hunt and Hess grade (IV or V), and timing of intervention (<24 hours or later) influenced the clinical outcome of the patients (P < 0.05), while sex, Fisher grade, hydrocephalus, the location of aneurysms, and cerebral vasospasm (CVS) not (P > 0.05). Furthermore, 65% of patients (22/34) operated within 24 hours after onset of hemorrhage had a good outcome compared with 20% of patients (5/25) operated at 24 to 48 hours in surgical group (P < 0.05). The results indicate that keyhole approach combined with external ventricular drainage is a safe and reliable treatment for ruptured, poor-grade, anterior circulation cerebral aneurysms in early stage, which will reduce mortality. PMID:26705215

  18. Agile Science Operations: A New Approach for Primitive Exploration Bodies

    NASA Technical Reports Server (NTRS)

    Chien, Steve A.; Thompson, David R.; Castillo-Rogez, Julie C.; Doyle, Richard; Estlin, Tara; Mclaren, David

    2012-01-01

    Primitive body exploration missions such as potential Comet Surface Sample Return or Trojan Tour and Rendezvous would challenge traditional operations practices. Earth-based observations would provide only basic understanding before arrival and many science goals would be defined during the initial rendezvous. It could be necessary to revise trajectories and observation plans to quickly characterize the target for safe, effective observations. Detection of outgassing activity and monitoring of comet surface activity are even more time constrained, with events occurring faster than round-trip light time. "Agile science operations" address these challenges with contingency plans that recognize the intrinsic uncertainty in the operating environment and science objectives. Planning for multiple alternatives can significantly improve the time required to repair and validate spacecraft command sequences. When appropriate, time-critical decisions can be automated and shifted to the spacecraft for immediate access to instrument data. Mirrored planning systems on both sides of the light-time gap permit transfer of authority back and forth as needed. We survey relevant science objectives, identifying time bottlenecks and the techniques that could be used to speed missions' reaction to new science data. Finally, we discuss the results of a trade study simulating agile observations during flyby and comet rendezvous scenarios. These experiments quantify instrument coverage of key surface features as a function of planning turnaround time. Careful application of agile operations techniques can play a significant role in realizing the Decadal Survey plan for primitive body exploration

  19. Agile Science Operations: A New Approach for Primitive Exploration Bodies

    NASA Technical Reports Server (NTRS)

    Chien, Steve A.; Thompson, David R.; Castillo-Rogez, Julie C.; Doyle, Richard; Estlin, Tara; Mclaren, David

    2012-01-01

    Primitive body exploration missions such as potential Comet Surface Sample Return or Trojan Tour and Rendezvous would challenge traditional operations practices. Earth-based observations would provide only basic understanding before arrival and many science goals would be defined during the initial rendezvous. It could be necessary to revise trajectories and observation plans to quickly characterize the target for safe, effective observations. Detection of outgassing activity and monitoring of comet surface activity are even more time constrained, with events occurring faster than round-trip light time. "Agile science operations" address these challenges with contingency plans that recognize the intrinsic uncertainty in the operating environment and science objectives. Planning for multiple alternatives can significantly improve the time required to repair and validate spacecraft command sequences. When appropriate, time-critical decisions can be automated and shifted to the spacecraft for immediate access to instrument data. Mirrored planning systems on both sides of the light-time gap permit transfer of authority back and forth as needed. We survey relevant science objectives, identifying time bottlenecks and the techniques that could be used to speed missions' reaction to new science data. Finally, we discuss the results of a trade study simulating agile observations during flyby and comet rendezvous scenarios. These experiments quantify instrument coverage of key surface features as a function of planning turnaround time. Careful application of agile operations techniques can play a significant role in realizing the Decadal Survey plan for primitive body exploration

  20. Managing fatigue in operational settings 2: An integrated approach

    NASA Technical Reports Server (NTRS)

    Rosekind, M. R.; Gander, P. H.; Gregory, K. B.; Smith, R. M.; Miller, D. L.; Oyung, R.; Webbon, L. L.; Johnson, J. M.

    1996-01-01

    The six domains that must be addressed in managing fatigue in operational settings are identified, and examples of how the aviation industry is dealing with the problems in each domain are given. Challenges facing healthcare providers in managing fatigue are also discussed.

  1. Formulation of Higher Education Institutional Strategy Using Operational Research Approaches

    ERIC Educational Resources Information Center

    Labib, Ashraf; Read, Martin; Gladstone-Millar, Charlotte; Tonge, Richard; Smith, David

    2014-01-01

    In this paper a framework is proposed for the formulation of a higher education institutional (HEI) strategy. This work provides a practical example, through a case study, to demonstrate how the proposed framework can be applied to the issue of formulation of HEI strategy. The proposed hybrid model is based on two operational research…

  2. Chemical approaches to zero blowdown operation (TP93-05)

    SciTech Connect

    Geiger, G.E.; Ogg, J.; Hatch, M.R.

    1993-03-01

    Zero blowdown operation was evaluated at a cooling tower at the Stanford Linear Accelerator Center in an attempt to eliminate cooling water discharge. Testing was performed with and without acid feed for pH control using a state-of-the-art treatment which contained polymer, phosphonate, and azole. Supplemental additional of a proprietary calcium carbonate scale inhibitor was also evaluated.

  3. Managing fatigue in operational settings 2: An integrated approach

    NASA Technical Reports Server (NTRS)

    Rosekind, M. R.; Gander, P. H.; Gregory, K. B.; Smith, R. M.; Miller, D. L.; Oyung, R.; Webbon, L. L.; Johnson, J. M.

    1996-01-01

    The six domains that must be addressed in managing fatigue in operational settings are identified, and examples of how the aviation industry is dealing with the problems in each domain are given. Challenges facing healthcare providers in managing fatigue are also discussed.

  4. A Problem-Solving Approach to Teaching Operant Conditioning

    ERIC Educational Resources Information Center

    Shields, Carolyn; Gredler, Margaret

    2003-01-01

    Psychology students frequently have misconceptions of basic concepts in operant conditioning. Prior classroom observations revealed that most students defined positive reinforcement as reward and equated negative reinforcement and punishment. Students also labeled positive reinforcement as rewarding good behavior and negative reinforcement as…

  5. Formulation of Higher Education Institutional Strategy Using Operational Research Approaches

    ERIC Educational Resources Information Center

    Labib, Ashraf; Read, Martin; Gladstone-Millar, Charlotte; Tonge, Richard; Smith, David

    2014-01-01

    In this paper a framework is proposed for the formulation of a higher education institutional (HEI) strategy. This work provides a practical example, through a case study, to demonstrate how the proposed framework can be applied to the issue of formulation of HEI strategy. The proposed hybrid model is based on two operational research…

  6. A Problem-Solving Approach to Teaching Operant Conditioning

    ERIC Educational Resources Information Center

    Shields, Carolyn; Gredler, Margaret

    2003-01-01

    Psychology students frequently have misconceptions of basic concepts in operant conditioning. Prior classroom observations revealed that most students defined positive reinforcement as reward and equated negative reinforcement and punishment. Students also labeled positive reinforcement as rewarding good behavior and negative reinforcement as…

  7. Matched Backprojection Operator for Combined Scanning Transmission Electron Microscopy Tilt- and Focal Series.

    PubMed

    Dahmen, Tim; Kohr, Holger; de Jonge, Niels; Slusallek, Philipp

    2015-06-01

    Combined tilt- and focal series scanning transmission electron microscopy is a recently developed method to obtain nanoscale three-dimensional (3D) information of thin specimens. In this study, we formulate the forward projection in this acquisition scheme as a linear operator and prove that it is a generalization of the Ray transform for parallel illumination. We analytically derive the corresponding backprojection operator as the adjoint of the forward projection. We further demonstrate that the matched backprojection operator drastically improves the convergence rate of iterative 3D reconstruction compared to the case where a backprojection based on heuristic weighting is used. In addition, we show that the 3D reconstruction is of better quality.

  8. Treatment of real industrial wastewater using the combined approach of advanced oxidation followed by aerobic oxidation.

    PubMed

    Ramteke, Lokeshkumar P; Gogate, Parag R

    2016-05-01

    Fenton oxidation and ultrasound-based pretreatment have been applied to improve the treatment of real industrial wastewater based on the use of biological oxidation. The effect of operating parameters such as Fe(2+) loading, contact time, initial pH, and hydrogen peroxide loading on the extent of chemical oxygen demand (COD) reduction and change in biochemical oxygen demand (BOD5)/COD ratio has been investigated. The optimum operating conditions established for the pretreatment were initial pH of 3.0, Fe(2+) loading of 2.0, and 2.5 g L(-1) for the US/Fenton/stirring and Fenton approach, respectively, and temperature of 25 °C with initial H2O2 loading of 1.5 g L(-1). The use of pretreatment resulted in a significant increase in the BOD5/COD ratio confirming the production of easily digestible intermediates. The effect of the type of sludge in the aerobic biodegradation was also investigated based on the use of primary activated sludge (PAS), modified activated sludge (MAS), and activated sludge (AS). Enhanced removal of the pollutants as well as higher biomass yield was observed for MAS as compared to PAS and AS. The use of US/Fenton/stirring pretreatment under the optimized conditions followed by biological oxidation using MAS resulted in maximum COD removal at 97.9 %. The required hydraulic retention time for the combined oxidation system was also significantly lower as compared to only biological oxidation operation. Kinetic studies revealed that the reduction in the COD followed a first-order kinetic model for advanced oxidation and pseudo first-order model for biodegradation. The study clearly established the utility of the combined technology for the effective treatment of real industrial wastewater.

  9. Computational biology approach to uncover hepatitis C virus helicase operation

    PubMed Central

    Flechsig, Holger

    2014-01-01

    Hepatitis C virus (HCV) helicase is a molecular motor that splits nucleic acid duplex structures during viral replication, therefore representing a promising target for antiviral treatment. Hence, a detailed understanding of the mechanism by which it operates would facilitate the development of efficient drug-assisted therapies aiming to inhibit helicase activity. Despite extensive investigations performed in the past, a thorough understanding of the activity of this important protein was lacking since the underlying internal conformational motions could not be resolved. Here we review investigations that have been previously performed by us for HCV helicase. Using methods of structure-based computational modelling it became possible to follow entire operation cycles of this motor protein in structurally resolved simulations and uncover the mechanism by which it moves along the nucleic acid and accomplishes strand separation. We also discuss observations from that study in the light of recent experimental studies that confirm our findings. PMID:24707123

  10. Aspect-Oriented Approach to Operating System Development Empirical Study

    NASA Astrophysics Data System (ADS)

    Kuusela, Jaakko; Tuominen, Harri

    This paper presents a case-study where a new programming technique is applied to an established branch of software development. The purpose of the study was to test whether or not aspect-oriented programming (AOP) could be used in operating systems development. Instead of any real world operating system an educational OS with the name Nachos was used. This was because Nachos is written in Java which makes it easy to introduce aspect-oriented techniques. In this paper a new file system for the Nachos OS is developed and then it is analyzed by profiling and metrics. The results show that it is possible to use AOP in OS development and that it is also beneficial to do so.

  11. Computational biology approach to uncover hepatitis C virus helicase operation.

    PubMed

    Flechsig, Holger

    2014-04-07

    Hepatitis C virus (HCV) helicase is a molecular motor that splits nucleic acid duplex structures during viral replication, therefore representing a promising target for antiviral treatment. Hence, a detailed understanding of the mechanism by which it operates would facilitate the development of efficient drug-assisted therapies aiming to inhibit helicase activity. Despite extensive investigations performed in the past, a thorough understanding of the activity of this important protein was lacking since the underlying internal conformational motions could not be resolved. Here we review investigations that have been previously performed by us for HCV helicase. Using methods of structure-based computational modelling it became possible to follow entire operation cycles of this motor protein in structurally resolved simulations and uncover the mechanism by which it moves along the nucleic acid and accomplishes strand separation. We also discuss observations from that study in the light of recent experimental studies that confirm our findings.

  12. Subtyping of Gliomaby Combining Gene Expression and CNVs Data Based on a Compressive Sensing Approach

    PubMed Central

    Tang, Wenlong; Cao, Hongbao; Zhang, Ji-Gang; Duan, Junbo; Lin, Dongdong; Wang, Yu-Ping

    2013-01-01

    It is realized that a combined analysis of different types of genomic measurements tends to give more reliable classification results. However, how to efficiently combine data with different resolutions is challenging. We propose a novel compressed sensing based approach for the combined analysis of gene expression and copy number variants data for the purpose of subtyping six types of Gliomas. Experimental results show that the proposed combined approach can substantially improve the classification accuracy compared to that of using either of individual data type. The proposed approach can be applicable to many other types of genomic data. PMID:25267935

  13. Effects-Based Approaches to Operations: Canadian Perspectives

    DTIC Science & Technology

    2008-04-01

    Gell - Mann , The Quark and the Jaguar (London: Abacus, 1994), 84-5. Note also that Gell - Mann also considers the rarity of revolutionary scientific...least so far. The first version, which operates in what Edward Mann describes as a conquest paradigm,21 has mated new technologies to an old idea to...other US government departments, agencies and bureaus.”175 The subject of a common planning process has also been discussed by Edward Mann et al.176

  14. A simulation approach to a virtual base defense operating center

    NASA Astrophysics Data System (ADS)

    Athmer, Keith; Gaughan, Chris

    2010-04-01

    The TRADOC Maneuver Support Center of Excellence (MSCoE) is the Army proponent for protection and in turn, has the mission to support fixed site protection issues. To this end, the Maneuver Support Battle Lab (MSBL) developed a Virtual Base Defense Operating Center (VBDOC) capability that was initiated in support of the Force Protection Joint Experiment (FPJE) to examine data fusion enhancements and improvements to the Common Operating Picture (COP) display. Furthermore BDOC Standard Operating Procedures (SOPs), Tactics, Techniques and Procedures (TTPs), and Unmanned Ground Vehicle (UGV) capabilities were examined in order to optimize manpower, reduce exposure of friendly personnel, and improve force protection. The Modeling and Simulation (M&S) architecture was especially important due to the cost of providing realistic environments, such as Chemical Biological Radiological Nuclear (CBRN) hazards, and the availability of soldiers for experimentation. The VBDOC simulation architecture contains a force-on-force simulation, a CBRN simulation, a desktop UGV Advanced Concepts Research Tool (ACRT) and a sensor controller using the Distributed Interactive Simulation (DIS) protocol. This simulation architecture stimulated actual Command and Control (C2) systems including the Joint Battlespace Command and Control System (JBC2S) and the Joint Warning and Reporting Network (JWARN). These C2 systems, along with video feeds from various sensors and unmanned vehicles, were used by Battle Captains and staffs for situational awareness of the battlefield while conducting the experiment. The VBDOC capability offers a controlled environment to study fixed site protection issues, such as future Concept of Operation (CONOP)/TTP/SOP development and refinement, examining emerging concepts, and assessing specific technology capabilities.

  15. The Supreme Allied Commander’s Operational Approach

    DTIC Science & Technology

    2014-05-22

    Army, 45 pages. Since the end of WWII, many historians have criticized General Eisenhower’s broad front strategy. These critics have argued that...unnecessarily prolonging the war. To highlight the errors in his broad front strategy, some critics have misrepresented General Eisenhower’s operational...leadership by presenting historical situations out of context or portraying his caution as timidity. However, a critical review of General Eisenhower’s

  16. Comparison and combination of several MeSH indexing approaches.

    PubMed

    Yepes, Antonio Jose Jimeno; Mork, James G; Demner-Fushman, Dina; Aronson, Alan R

    2013-01-01

    MeSH indexing of MEDLINE is becoming a more difficult task for the group of highly qualified indexing staff at the US National Library of Medicine, due to the large yearly growth of MEDLINE and the increasing size of MeSH. Since 2002, this task has been assisted by the Medical Text Indexer or MTI program. We extend previous machine learning analysis by adding a more diverse set of MeSH headings targeting examples where MTI has been shown to perform poorly. Machine learning algorithms exceed MTI's performance on MeSH headings that are used very frequently and headings for which the indexing frequency is very low. We find that when we combine the MTI suggestions and the prediction of the learning algorithms, the performance improves compared to any single method for most of the evaluated MeSH headings.

  17. Comparison and combination of several MeSH indexing approaches

    PubMed Central

    Yepes, Antonio Jose Jimeno; Mork, James G.; Demner-Fushman, Dina; Aronson, Alan R.

    2013-01-01

    MeSH indexing of MEDLINE is becoming a more difficult task for the group of highly qualified indexing staff at the US National Library of Medicine, due to the large yearly growth of MEDLINE and the increasing size of MeSH. Since 2002, this task has been assisted by the Medical Text Indexer or MTI program. We extend previous machine learning analysis by adding a more diverse set of MeSH headings targeting examples where MTI has been shown to perform poorly. Machine learning algorithms exceed MTI’s performance on MeSH headings that are used very frequently and headings for which the indexing frequency is very low. We find that when we combine the MTI suggestions and the prediction of the learning algorithms, the performance improves compared to any single method for most of the evaluated MeSH headings. PMID:24551371

  18. Approach to combined-function magnets via symplectic slicing

    NASA Astrophysics Data System (ADS)

    Titze, M.

    2016-05-01

    In this article we describe how to obtain symplectic "slice" maps for combined-function magnets, by using a method of generating functions. A feature of this method is that one can use an unexpanded and unsplit Hamiltonian. From such a slice map we obtain a first-order map which is symplectic at the closed orbit. We also obtain a symplectic kick map. Both results were implemented into the widely used program MAD-X to regain, in particular, the twiss parameters for the sliced model of the Proton Synchrotron at CERN. In addition, we obtain recursion equations for symplectic maps of general time-dependent Hamiltonians, which might be useful even beyond the scope of accelerator physics.

  19. The Wisconsin approach to newborn screening for severe combined immunodeficiency.

    PubMed

    Verbsky, James; Thakar, Monica; Routes, John

    2012-03-01

    Severe combined immunodeficiency (SCID) is a life-threatening disease of infants that is curable with hematopoietic cell transplantation if detected early. Population-based screening for SCID using the T-cell receptor excision circle (TREC) assay began in Wisconsin in 2008; 5 infants with SCID or other forms of severe T-cell lymphopenia (TCL) have been detected, and no infants with SCID have been missed. This review will provide an overview of the TREC screening assay and an update of the findings from Wisconsin on all infants screened from January 1, 2008, until December 31, 2010. Importantly, we give practical recommendations regarding newborn population-based screening using the TREC assay, including the evaluation and care of infants detected.

  20. Sand Compositional Analysis Using a Combined Geological and Spectroscopic Approach

    NASA Astrophysics Data System (ADS)

    Smith, Molly Elizabeth

    Many minerals, such as calcite and magnetite, show diagnostic overtone and combination bands in the 350-2500 nm window. Sand, though an important unconsolidated material with great abundance on the Earth's surface, is largely overlooked in spectroscopic studies. Over 100 sand samples were analyzed through traditional microscopic methods and compared to spectral reflectance collected via an ASD Spectroradiometer. Multiple methods were chosen to compare spectroscopic data to sand composition and grain size: 1) existing spectral indices, 2) continuum removal, 3) derivative analysis, and 4) correlation analysis. Particular focus was given to carbonate content. Results from derivative and correlation analysis showed strong correlations in the 2180-2240 nm and 2300-2360 nm windows to carbonate content. Proposed here is the Normalized Difference Carbonate Sand Index (NDCSI), which showed Pearson correlations of r=-0.78 for light-colored samples and r=-0.77 for all samples used. This index is viable for use with carbonate-rich sands.

  1. An approach to autonomous operations for remote mobile robotic exploration

    NASA Technical Reports Server (NTRS)

    Chouinard, C.; Fisher, F.; Gaines, D.; Estlin, T.; Schaffer, S.

    2003-01-01

    This paper presents arguments for a balanced approach to modelling and reasoning in an autonomous robotic system. The framework discussed utilizes both declarative and procedural modelling to define the domain, rules, and constraints of the system and also balances the use of deliberative and reactive reasoning during execution.

  2. Preparing Higher Education Leaders: A Conceptual, Strategic, and Operational Approach

    ERIC Educational Resources Information Center

    Gigliotti, Ralph A.; Ruben, Brent D.

    2017-01-01

    This article begins with a review of the current higher education landscape, focusing particularly on a number of leadership challenges that are most germane to colleges and universities across the globe. The article continues with a review of the existing literature on higher education leadership needs and competencies, and current approaches to…

  3. Preparing Higher Education Leaders: A Conceptual, Strategic, and Operational Approach

    ERIC Educational Resources Information Center

    Gigliotti, Ralph A.; Ruben, Brent D.

    2017-01-01

    This article begins with a review of the current higher education landscape, focusing particularly on a number of leadership challenges that are most germane to colleges and universities across the globe. The article continues with a review of the existing literature on higher education leadership needs and competencies, and current approaches to…

  4. An Estimation of Erinaceidae Phylogeny: A Combined Analysis Approach

    PubMed Central

    Yamaguchi, Nobuyuki; Ai, Huai-Sen; Wang, Ying-Xiang; Zhang, Ya-Ping; Jiang, Xue-Long

    2012-01-01

    Background Erinaceidae is a family of small mammals that include the spiny hedgehogs (Erinaceinae) and the silky-furred moonrats and gymnures (Galericinae). These animals are widely distributed across Eurasia and Africa, from the tundra to the tropics and the deserts to damp forests. The importance of these animals lies in the fact that they are the oldest known living placental mammals, which are well represented in the fossil record, a rarity fact given their size and vulnerability to destruction during fossilization. Although the Family has been well studied, their phylogenetic relationships remain controversial. To test previous phylogenetic hypotheses, we combined molecular and morphological data sets, including representatives of all the genera. Methodology and Principal Findings We included in the analyses 3,218 bp mitochondrial genes, one hundred and thirty-five morphological characters, twenty-two extant erinaceid taxa, and five outgroup taxa. Phylogenetic relationships were reconstructed using both partitioned and combined data sets. As in previous analyses, our results strongly support the monophyly of both subfamilies (Galericinae and Erinaceinae), the Hylomys group (to include Neotetracus and Neohylomys), and a sister-relationship of Atelerix and Erinaceus. As well, we verified that the extremely long branch lengths within the Galericinae are consistent with their fossil records. Not surprisingly, we found significant incongruence between the phylogenetic signals of the genes and the morphological characters, specifically in the case of Hylomys parvus, Mesechinus, and relationships between Hemiechinus and Paraechinus. Conclusions Although we discovered new clues to understanding the evolutionary relationships within the Erinaceidae, our results nonetheless, strongly suggest that more robust analyses employing more complete taxon sampling (to include fossils) and multiple unlinked genes would greatly enhance our understanding of the Erinaceidae. Until

  5. A combined approach to cartographic displacement for buildings based on skeleton and improved elastic beam algorithm.

    PubMed

    Liu, Yuangang; Guo, Qingsheng; Sun, Yageng; Ma, Xiaoya

    2014-01-01

    Scale reduction from source to target maps inevitably leads to conflicts of map symbols in cartography and geographic information systems (GIS). Displacement is one of the most important map generalization operators and it can be used to resolve the problems that arise from conflict among two or more map objects. In this paper, we propose a combined approach based on constraint Delaunay triangulation (CDT) skeleton and improved elastic beam algorithm for automated building displacement. In this approach, map data sets are first partitioned. Then the displacement operation is conducted in each partition as a cyclic and iterative process of conflict detection and resolution. In the iteration, the skeleton of the gap spaces is extracted using CDT. It then serves as an enhanced data model to detect conflicts and construct the proximity graph. Then, the proximity graph is adjusted using local grouping information. Under the action of forces derived from the detected conflicts, the proximity graph is deformed using the improved elastic beam algorithm. In this way, buildings are displaced to find an optimal compromise between related cartographic constraints. To validate this approach, two topographic map data sets (i.e., urban and suburban areas) were tested. The results were reasonable with respect to each constraint when the density of the map was not extremely high. In summary, the improvements include (1) an automated parameter-setting method for elastic beams, (2) explicit enforcement regarding the positional accuracy constraint, added by introducing drag forces, (3) preservation of local building groups through displacement over an adjusted proximity graph, and (4) an iterative strategy that is more likely to resolve the proximity conflicts than the one used in the existing elastic beam algorithm.

  6. A Combined Approach to Cartographic Displacement for Buildings Based on Skeleton and Improved Elastic Beam Algorithm

    PubMed Central

    Liu, Yuangang; Guo, Qingsheng; Sun, Yageng; Ma, Xiaoya

    2014-01-01

    Scale reduction from source to target maps inevitably leads to conflicts of map symbols in cartography and geographic information systems (GIS). Displacement is one of the most important map generalization operators and it can be used to resolve the problems that arise from conflict among two or more map objects. In this paper, we propose a combined approach based on constraint Delaunay triangulation (CDT) skeleton and improved elastic beam algorithm for automated building displacement. In this approach, map data sets are first partitioned. Then the displacement operation is conducted in each partition as a cyclic and iterative process of conflict detection and resolution. In the iteration, the skeleton of the gap spaces is extracted using CDT. It then serves as an enhanced data model to detect conflicts and construct the proximity graph. Then, the proximity graph is adjusted using local grouping information. Under the action of forces derived from the detected conflicts, the proximity graph is deformed using the improved elastic beam algorithm. In this way, buildings are displaced to find an optimal compromise between related cartographic constraints. To validate this approach, two topographic map data sets (i.e., urban and suburban areas) were tested. The results were reasonable with respect to each constraint when the density of the map was not extremely high. In summary, the improvements include (1) an automated parameter-setting method for elastic beams, (2) explicit enforcement regarding the positional accuracy constraint, added by introducing drag forces, (3) preservation of local building groups through displacement over an adjusted proximity graph, and (4) an iterative strategy that is more likely to resolve the proximity conflicts than the one used in the existing elastic beam algorithm. PMID:25470727

  7. A Robust Design Approach to Cost Estimation: Solar Energy for Marine Corps Expeditionary Operations

    DTIC Science & Technology

    2014-07-14

    Resources Energy Technology Basics Electricity Grid Basics Costs Renewable Technologies Biomass Geothermal Solar Concentrators Solar Photovoltaics Wind...SPONSORED REPORT SERIES A Robust Design Approach to Cost Estimation: Solar Energy for Marine Corps Expeditionary Operations 14 July 2014...SUBTITLE A Robust Design Approach to Cost Estimation: Solar Energy for Marine Corps Expeditionary Operations 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  8. A supramolecular approach to combining enzymatic and transition metal catalysis

    NASA Astrophysics Data System (ADS)

    Wang, Z. Jane; Clary, Kristen N.; Bergman, Robert G.; Raymond, Kenneth N.; Toste, F. Dean

    2013-02-01

    The ability of supramolecular host-guest complexes to catalyse organic reactions collaboratively with an enzyme is an important goal in the research and discovery of synthetic enzyme mimics. Herein we present a variety of catalytic tandem reactions that employ esterases, lipases or alcohol dehydrogenases and gold(I) or ruthenium(II) complexes encapsulated in a Ga4L6 tetrahedral supramolecular cluster. The host-guest complexes are tolerated well by the enzymes and, in the case of the gold(I) host-guest complex, show improved reactivity relative to the free cationic guest. We propose that supramolecular encapsulation of organometallic complexes prevents their diffusion into the bulk solution, where they can bind amino-acid residues on the proteins and potentially compromise their activity. Our observations underline the advantages of the supramolecular approach and suggest that encapsulation of reactive complexes may provide a general strategy for carrying out classic organic reactions in the presence of biocatalysts.

  9. Combined microphone array and lock-in amplifier operations for outdoor photo-acoustic sensing

    NASA Astrophysics Data System (ADS)

    Islam, Mohammad; Lay, Joshua; Wang, Chen-Chia; Trivedi, Sudhir; Samuels, Alan; Khurgin, Jacob; Sen-Choa, Fow

    2005-05-01

    Mid-infrared (MIR) standoff photoacoustic (PA) sensing of explosive chemicals and nerve gas stimulants at calibrated concentration have been demonstrated in door. When they are operated out door, array beam forming technique has to be employed to reject ambient noise and enhance signal. Lock-in amplifier usually needs to be used to achieve weak signal detection in a noisy environment. If we can combine these two techniques we will be able to reject both spatial and temporal noise and achieve a great signal to noise ratio (SNR) performance. From the best of our knowledge no literature has described how to combine these two techniques. In this work we demonstrated combined array and lock in amplifier operation in outdoor environment. A simplified system includes a signal generator, a speaker source, a lock in amplifier, 4 spy-phones with 4 parabolic reflectors to collect the acoustic signal, a National-Instrument NI6259 data acquisition system with both A to D (ADC) and D to A converters (DAC), and a PC. To combine these two techniques, each of the array collected signals was digitized by the ADC. Their path delays were adjusted in the computer to synchronize the phase. By using a PC controlled ADC the processing time is very long (~1s). To synchronize them without using costly high-speed customer made hardware, we delayed the reference signal by send it through the same ADC- PCDAC path as the array signals. By doing so, a good lock-in operation with stable phase was obtained.

  10. Cleared for the visual approach: Human factor problems in air carrier operations

    NASA Technical Reports Server (NTRS)

    Monan, W. P.

    1983-01-01

    The study described herein, a set of 353 ASRS reports of unique aviation occurrences significantly involving visual approaches was examined to identify hazards and pitfalls embedded in the visual approach procedure and to consider operational practices that might help avoid future mishaps. Analysis of the report set identified nine aspects of the visual approach procedure that appeared to be predisposing conditions for inducing or exacerbating the effects of operational errors by flight crew members or controllers. Predisposing conditions, errors, and operational consequences of the errors are discussed. In a summary, operational policies that might mitigate the problems are examined.

  11. Computational approach to Thornley's problem by bivariate operational calculus

    NASA Astrophysics Data System (ADS)

    Bazhlekova, E.; Dimovski, I.

    2012-10-01

    Thornley's problem is an initial-boundary value problem with a nonlocal boundary condition for linear onedimensional reaction-diffusion equation, used as a mathematical model of spiral phyllotaxis in botany. Applying a bivariate operational calculus we find explicit representation of the solution, containing two convolution products of special solutions and the arbitrary initial and boundary functions. We use a non-classical convolution with respect to the space variable, extending in this way the classical Duhamel principle. The special solutions involved are represented in the form of fast convergent series. Numerical examples are considered to show the application of the present technique and to analyze the character of the solution.

  12. Spatial operator approach to flexible manipulator inverse and forward dynamics

    NASA Technical Reports Server (NTRS)

    Rodriguez, G.

    1990-01-01

    This study extends to flexible multibody manipulators the recent results of the author on the use of spatially recursive filtering and smoothing techniques for robot arm dynamics. The configuration analyzed is that of a mechanical system of flexible bodies joined together by articulated joints. The inverse and forward dynamics problems are solved using the techniques of spatially recursive Kalman filtering and smoothing. The algorithms are easily developed using a set of identities associated with mass matrix factorization and inversion. The identities are easily derived using a spatial operator algebra developed by the author.

  13. Spatial operator approach to flexible multibody system dynamics and control

    NASA Technical Reports Server (NTRS)

    Rodriguez, G.

    1991-01-01

    The inverse and forward dynamics problems for flexible multibody systems were solved using the techniques of spatially recursive Kalman filtering and smoothing. These algorithms are easily developed using a set of identities associated with mass matrix factorization and inversion. These identities are easily derived using the spatial operator algebra developed by the author. Current work is aimed at computational experiments with the described algorithms and at modelling for control design of limber manipulator systems. It is also aimed at handling and manipulation of flexible objects.

  14. Rational stabilization of complex proteins: a divide and combine approach

    PubMed Central

    Lamazares, Emilio; Clemente, Isabel; Bueno, Marta; Velázquez-Campoy, Adrián; Sancho, Javier

    2015-01-01

    Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully cooperative proteins. We show that the key to stabilize the latter is to know the regions of lower stability. To prove it, we have engineered apoflavodoxin, a non-fully cooperative protein on which previous thermostabilizing attempts had failed. We use a step-wise combination of structure-based, rationally-designed, stabilizing mutations confined to the less stable structural region, and obtain variants that, according to their van't Hoff to calorimetric enthalpy ratios, exhibit fully-cooperative thermal unfolding with a melting temperature of 75°C, 32 degrees above the lower melting temperature of the non-cooperative wild type protein. The ideas introduced here may also be useful for the thermostabilization of complex proteins through formulation or using specific stabilizing ligands (e.g. pharmacological chaperones). PMID:25774740

  15. Using the PPML approach for constructing a low-dissipation, operator-splitting scheme for numerical simulations of hydrodynamic flows

    NASA Astrophysics Data System (ADS)

    Kulikov, Igor; Vorobyov, Eduard

    2016-07-01

    An approach for constructing a low-dissipation numerical method is described. The method is based on a combination of the operator-splitting method, Godunov method, and piecewise-parabolic method on the local stencil. Numerical method was tested on a standard suite of hydrodynamic test problems. In addition, the performance of the method is demonstrated on a global test problem showing the development of a spiral structure in a gravitationally unstable gaseous galactic disk.

  16. Combining qualitative and quantitative operational research methods to inform quality improvement in pathways that span multiple settings

    PubMed Central

    Crowe, Sonya; Brown, Katherine; Tregay, Jenifer; Wray, Jo; Knowles, Rachel; Ridout, Deborah A; Bull, Catherine; Utley, Martin

    2017-01-01

    Background Improving integration and continuity of care across sectors within resource constraints is a priority in many health systems. Qualitative operational research methods of problem structuring have been used to address quality improvement in services involving multiple sectors but not in combination with quantitative operational research methods that enable targeting of interventions according to patient risk. We aimed to combine these methods to augment and inform an improvement initiative concerning infants with congenital heart disease (CHD) whose complex care pathway spans multiple sectors. Methods Soft systems methodology was used to consider systematically changes to services from the perspectives of community, primary, secondary and tertiary care professionals and a patient group, incorporating relevant evidence. Classification and regression tree (CART) analysis of national audit datasets was conducted along with data visualisation designed to inform service improvement within the context of limited resources. Results A ‘Rich Picture’ was developed capturing the main features of services for infants with CHD pertinent to service improvement. This was used, along with a graphical summary of the CART analysis, to guide discussions about targeting interventions at specific patient risk groups. Agreement was reached across representatives of relevant health professions and patients on a coherent set of targeted recommendations for quality improvement. These fed into national decisions about service provision and commissioning. Conclusions When tackling complex problems in service provision across multiple settings, it is important to acknowledge and work with multiple perspectives systematically and to consider targeting service improvements in response to confined resources. Our research demonstrates that applying a combination of qualitative and quantitative operational research methods is one approach to doing so that warrants further

  17. Combining qualitative and quantitative operational research methods to inform quality improvement in pathways that span multiple settings.

    PubMed

    Crowe, Sonya; Brown, Katherine; Tregay, Jenifer; Wray, Jo; Knowles, Rachel; Ridout, Deborah A; Bull, Catherine; Utley, Martin

    2017-08-01

    Improving integration and continuity of care across sectors within resource constraints is a priority in many health systems. Qualitative operational research methods of problem structuring have been used to address quality improvement in services involving multiple sectors but not in combination with quantitative operational research methods that enable targeting of interventions according to patient risk. We aimed to combine these methods to augment and inform an improvement initiative concerning infants with congenital heart disease (CHD) whose complex care pathway spans multiple sectors. Soft systems methodology was used to consider systematically changes to services from the perspectives of community, primary, secondary and tertiary care professionals and a patient group, incorporating relevant evidence. Classification and regression tree (CART) analysis of national audit datasets was conducted along with data visualisation designed to inform service improvement within the context of limited resources. A 'Rich Picture' was developed capturing the main features of services for infants with CHD pertinent to service improvement. This was used, along with a graphical summary of the CART analysis, to guide discussions about targeting interventions at specific patient risk groups. Agreement was reached across representatives of relevant health professions and patients on a coherent set of targeted recommendations for quality improvement. These fed into national decisions about service provision and commissioning. When tackling complex problems in service provision across multiple settings, it is important to acknowledge and work with multiple perspectives systematically and to consider targeting service improvements in response to confined resources. Our research demonstrates that applying a combination of qualitative and quantitative operational research methods is one approach to doing so that warrants further consideration. Published by the BMJ Publishing Group

  18. [An approach to correcting scoliosis. Mechanism and operative procedure].

    PubMed

    Liang, D

    1991-04-01

    In the treatment of scoliosis, we found that soft tissue contracture on the concave side is the main force maintaining deformity, resisting correction and rejecting implants. So the release of contracture would get rid of the bow-string effect of the contractured tissues from the main curve, such as the capsules and ligaments around costo-transverse joints, the inter-transverse and intercostal muscles, together with the posterior section of the corresponding ribs would also be taken off by those shrunken tissues close to the main curve, like the capsules and ligaments around the costo-vertebral joints. Since 1982, 23 patients aged 6 to 16 years were treated operatively. The operation was done in 2 stages: contracture release on the concave side and fusion with bone grafting on both side laminae through body cast. Follow up for 1 to 8.5 years showed satisfactory results. The mechanism and effect of soft tissue contracture of idiopathic and congenital scoliosis are discussed in detail.

  19. Data convolution and combination operation (COCOA) for motion ghost artifacts reduction.

    PubMed

    Huang, Feng; Lin, Wei; Börnert, Peter; Li, Yu; Reykowski, Arne

    2010-07-01

    A novel method, data convolution and combination operation, is introduced for the reduction of ghost artifacts due to motion or flow during data acquisition. Since neighboring k-space data points from different coil elements have strong correlations, a new "synthetic" k-space with dispersed motion artifacts can be generated through convolution for each coil. The corresponding convolution kernel can be self-calibrated using the acquired k-space data. The synthetic and the acquired data sets can be checked for consistency to identify k-space areas that are motion corrupted. Subsequently, these two data sets can be combined appropriately to produce a k-space data set showing a reduced level of motion induced error. If the acquired k-space contains isolated error, the error can be completely eliminated through data convolution and combination operation. If the acquired k-space data contain widespread errors, the application of the convolution also significantly reduces the overall error. Results with simulated and in vivo data demonstrate that this self-calibrated method robustly reduces ghost artifacts due to swallowing, breathing, or blood flow, with a minimum impact on the image signal-to-noise ratio. (c) 2010 Wiley-Liss, Inc.

  20. Automation of the CCTV-mediated detection of individuals illegally carrying firearms: combining psychological and technological approaches

    NASA Astrophysics Data System (ADS)

    Darker, Iain T.; Kuo, Paul; Yang, Ming Yuan; Blechko, Anastassia; Grecos, Christos; Makris, Dimitrios; Nebel, Jean-Christophe; Gale, Alastair G.

    2009-05-01

    Findings from the current UK national research programme, MEDUSA (Multi Environment Deployable Universal Software Application), are presented. MEDUSA brings together two approaches to facilitate the design of an automatic, CCTV-based firearm detection system: psychological-to elicit strategies used by CCTV operators; and machine vision-to identify key cues derived from camera imagery. Potentially effective human- and machine-based strategies have been identified; these will form elements of the final system. The efficacies of these algorithms have been tested on staged CCTV footage in discriminating between firearms and matched distractor objects. Early results indicate the potential for this combined approach.

  1. 78 FR 4879 - Nine Mile Point 3 Nuclear Project, LLC and UniStar Nuclear Operating Services, LLC Combined...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... COMMISSION Nine Mile Point 3 Nuclear Project, LLC and UniStar Nuclear Operating Services, LLC Combined... Nuclear Project, LLC, and UniStar Nuclear Operating Services, LLC (UniStar), submitted a Combined License...) application for UniStar's Calvert Cliffs Nuclear Power Plant, Unit 3 (CCNPP3). The NRC docketed the...

  2. A Combined Epidemiologic and Metabolomic Approach Improves CKD Prediction

    PubMed Central

    Clish, Clary B.; Ghorbani, Anahita; Larson, Martin G.; Elmariah, Sammy; McCabe, Elizabeth; Yang, Qiong; Cheng, Susan; Pierce, Kerry; Deik, Amy; Souza, Amanda L.; Farrell, Laurie; Domos, Carly; Yeh, Robert W.; Palacios, Igor; Rosenfield, Kenneth; Vasan, Ramachandran S.; Florez, Jose C.; Wang, Thomas J.; Fox, Caroline S.

    2013-01-01

    Metabolomic approaches have begun to catalog the metabolic disturbances that accompany CKD, but whether metabolite alterations can predict future CKD is unknown. We performed liquid chromatography/mass spectrometry–based metabolite profiling on plasma from 1434 participants in the Framingham Heart Study (FHS) who did not have CKD at baseline. During the following 8 years, 123 individuals developed CKD, defined by an estimated GFR of <60 ml/min per 1.73 m2. Numerous metabolites were associated with incident CKD, including 16 that achieved the Bonferroni-adjusted significance threshold of P≤0.00023. To explore how the human kidney modulates these metabolites, we profiled arterial and renal venous plasma from nine individuals. Nine metabolites that predicted CKD in the FHS cohort decreased more than creatinine across the renal circulation, suggesting that they may reflect non–GFR-dependent functions, such as renal metabolism and secretion. Urine isotope dilution studies identified citrulline and choline as markers of renal metabolism and kynurenic acid as a marker of renal secretion. In turn, these analytes remained associated with incident CKD in the FHS cohort, even after adjustment for eGFR, age, sex, diabetes, hypertension, and proteinuria at baseline. Addition of a multimarker metabolite panel to clinical variables significantly increased the c-statistic (0.77–0.83, P<0.0001); net reclassification improvement was 0.78 (95% confidence interval, 0.60 to 0.95; P<0.0001). Thus, the addition of metabolite profiling to clinical data may significantly improve the ability to predict whether an individual will develop CKD by identifying predictors of renal risk that are independent of estimated GFR. PMID:23687356

  3. Physical fitness: An operator's approach to coping with shift work

    SciTech Connect

    Hanks, D.H.

    1989-01-01

    There is a strong correlation between a shift worker's ability to remain alert and the physical fitness of the individual. Alertness is a key element of a nuclear plant operator's ability to effectively monitor and control plant status. The constant changes in one's metabolism caused by the rotation of work (and sleep) hours can be devastating to his or her health. Many workers with longevity in the field, however, have found it beneficial to maintain some sort of workout or sport activity, feeling that this activity offsets the physical burden of backshift. The author's experience working shifts for 10 years and his reported increase in alertness through exercise and diet manipulation are described in this paper.

  4. Simulating California Reservoir Operation Using the Classification and Regression Tree Algorithm Combined with a Shuffled Cross-Validation Scheme

    NASA Astrophysics Data System (ADS)

    Yang, T.; Gao, X.; Sorooshian, S.; Li, X.

    2015-12-01

    The controlled outflows from a reservoir or dam are highly dependent on the decisions made by the reservoir operators, instead of a natural hydrological process. Difference exists between the natural upstream inflows to reservoirs, and the controlled outflows from reservoirs that supply the downstream users. With the decision maker's awareness of changing climate, reservoir management requires adaptable means to incorporate more information into decision making, such as the consideration of policy and regulation, environmental constraints, dry/wet conditions, etc. In this paper, a reservoir outflow simulation model is presented, which incorporates one of the well-developed data-mining models (Classification and Regression Tree) to predict the complicated human-controlled reservoir outflows and extract the reservoir operation patterns. A shuffled cross-validation approach is further implemented to improve model's predictive performance. An application study of 9 major reservoirs in California is carried out and the simulated results from different decision tree approaches are compared with observation, including original CART and Random Forest. The statistical measurements show that CART combined with the shuffled cross-validation scheme gives a better predictive performance over the other two methods, especially in simulating the peak flows. The results for simulated controlled outflow, storage changes and storage trajectories also show that the proposed model is able to consistently and reasonably predict the human's reservoir operation decisions. In addition, we found that the operation in the Trinity Lake, Oroville Lake and Shasta Lake are greatly influenced by policy and regulation, while low elevation reservoirs are more sensitive to inflow amount than others.

  5. Business Sector Development: A Critical Component of an Operational Approach to Stability Operations

    DTIC Science & Technology

    2010-11-30

    statistically significant in predicting the onset of civil war. See: Paul Collier, Anke Hoeffler, and Nicholas Sambanis. The Collier-Hoeffler Model of...See: Paul Collier and Anke Hoeffler, Aid, Policy, and Growth in Post-Conflict...Anthony W. Snodgrass, and Gregory J. Ehlers , “Input-Output Modeling for Assessing Cascading Effects,” Military Operations Research, Volume 10

  6. Safety approaches for high power modular laser operation

    NASA Astrophysics Data System (ADS)

    Handren, R. T.

    1993-03-01

    Approximately 20 years ago, a program was initiated at the Lawrence Livermore National Laboratory (LLNL) to study the feasibility of using lasers to separate isotopes of uranium and other materials. Of particular interest was the development of a uranium enrichment method for the production of commercial nuclear power reactor fuel to replace current more expensive methods. The Uranium Atomic Vapor Laser Isotope Separation (U-AVLIS) Program progressed to the point where a plant-scale facility to demonstrate commercial feasibility was built and is being tested. The U-AVLIS Program uses copper vapor lasers which pump frequency selective dye lasers to photoionize uranium vapor produced by an electron beam. The selectively ionized isotopes are electrostatically collected. The copper lasers are arranged in oscillator/amplifier chains. The current configuration consists of 12 chains, each with a nominal output of 800 W for a system output in excess of 9 kW. The system requirements are for continuous operation (24 h a day, 7 days a week) and high availability. To meet these requirements, the lasers are designed in a modular form allowing for rapid change-out of the lasers requiring maintenance. Since beginning operation in early 1985, the copper lasers have accumulated over 2 million unit hours at a greater than 90% availability. The dye laser system provides approximately 2.5 kW average power in the visible wavelength range. This large-scale laser system has many safety considerations, including high-power laser beams, high voltage, and large quantities (approximately 3000 gal) of ethanol dye solutions. The Laboratory's safety policy requires that safety controls be designed into any process, equipment, or apparatus in the form of engineering controls. Administrative controls further reduce the risk to an acceptable level. Selected examples of engineering and administrative controls currently being used in the U-AVLIS Program are described.

  7. Engineering nanomaterials with a combined electrochemical and molecular biomimetic approach

    NASA Astrophysics Data System (ADS)

    Dai, Haixia

    Biocomposite materials, such as bones, teeth, and shells, are created using mild aqueous solution-based processes near room temperature. Proteins add flexibility to these processes by facilitating the nucleation, growth, and ordering of specific inorganic materials into hierarchical structures. We aim to develop a biomimetic strategy for engineering technologically relevant inorganic materials with controlled compositions and structures, as Nature does, using proteins to orchestrate material formation and assembly. This approach involves three basic steps: (i) preparation of inorganic substrates compatible with combinatorial polypeptide screening; (ii) identification of inorganic-binding polypeptides and their engineering into inorganic-binding proteins; and (iii) protein-mediated inorganic nucleation and organization. Cuprous oxide (Cu2O), a p-type semiconductor, has been used to demonstrate all three steps. Zinc oxide (ZnO), an n-type semiconductor, has been used to show the generality of selected steps. Step (i), preparation of high quality inorganic substrates to select inorganic-binding polypeptides, was accomplished using electrochemical microfabrication to grow and pattern Cu2O and ZnO. Raman spectroscopy and x-ray photoelectron spectroscopy were used to verify phase purity and compositional stability of these surfaces during polypeptide screening. Step (ii), accomplished in collaboration with personnel in Prof Baneyx' lab at the University of Washington, involved incubating the inorganic substrates with the FliTrx(TM) random peptide library to identify cysteine-constrained dodecapeptides that bind the targeted inorganic. Insertion of a Cu2O-binding dodecapeptide into the DNA-binding protein TraI endowed the engineered TraI with strong affinity for Cu2O (Kd ≈ 10 -8 M). Finally, step (iii) involved nonequilibrium synthesis and organization of Cu2O nanoparticles, taking advantage of the inorganic and DNA recognition properties of the engineered TraI. The

  8. Application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital development.

    PubMed

    Tao, Z-Q; Shi, A-M

    2016-05-01

    The aim of this study is to explore the application of Boston matrix combined with SWOT analysis on operational development and evaluations of hospital departments. We selected 73 clinical and medical technology departments of our hospital from 2011 to 2013, and evaluated our hospital by Boston matrix combined with SWOT analysis according to the volume of services, medical quality, work efficiency, patients' evaluations, development capacity, operational capability, economic benefits, comprehensive evaluation of hospital achievement, innovation ability of hospital, influence of hospital, human resources of hospital, health insurance costs, etc. It was found that among clinical departments, there were 11 in Stars (22.4%), 17 in cash cow (34.7%), 15 in question marks (31.2%), 6 Dogs (12.2%), 16 in the youth stage of life cycle assessment (27.6%), 14 in the prime stage (24.1%), 12 in the stationary stage (20.7%), 9 in the aristocracy stage (15.5%) and 7 in the recession stage (12.1%). Among medical technology departments, there were 5 in Stars (20.8%), 1 in Cash cow (4.2%), 10 in question marks (41.6%), 8 Dogs (29.1%), 9 in the youth stage of life cycle assessment (37.5%), 4 in the prime stage (16.7%), 4 in the stable stage (16.7%), 1 in the aristocracy stage (4.2%) and 6 in the recession stage (25%). In conclusion, Boston matrix combined with SWOT analysis is suitable for operational development and comprehensive evaluations of hospital development, and it plays an important role in providing hospitals with development strategies.

  9. [Obstructive laryngeal disease and obstructive sleep apnoea syndrome, a combination with serious peri-operative risk].

    PubMed

    Ayuso, M A; Sánchez-Etayo, G; Polanco, M; Risco, R

    2014-11-01

    We present the case of a patient who was diagnosed with chronic bronchitis, obstructive sleep apnoea syndrome, and large Reinke laryngeal oedemas that were removed by transoral laser microsurgery. In the immediate post-operative period acute respiratory insufficiency occurred due to pharyngeal collapse that required emergency re-intubation, after which the patient was transferred to the ICU where mechanical ventilation was given for 18h. Subsequent progress was normal. We describe the combination of various risk-factors related to anaesthetic management and the importance of considering each one of them, especially the preoperative detection of the severity of obstructive sleep apnoea syndrome.

  10. Nez Perce Tribal Hatchery Project : Combined-Planning & Design and Operations & Maintenance Reports, 2000 Annual Report.

    SciTech Connect

    Larson, Roy Edward; Walker, Grant W.

    2002-12-31

    Nez Perce Tribal Hatchery (NPTH) Year-2000 Combined Maintenance and Operations (O&M) and Planning and Design (P&D) contract is hereby completed based on this annual report patterned after the Statement of Work (SOW) for the project as contracted with Bonneville Power Administration. Primary project activities focused on completion of the Northwest Power Planning Council Step-3 process that: (1) Accepted final design, (2) Authorized a capital construction amount of $16,050,000, and (3) Authorized contractor selection, and (4) Provided construction site dedication, and (5) Implemented construction activities over an anticipated 2-year period of July 2000 through October 2002.

  11. Transoral endoscopic thyroidectomy via vestibular approach: operative steps and video

    PubMed Central

    Bacuzzi, Alessandro; Lavazza, Matteo; Inversini, Davide; Pappalardo, Vincenzo; Boni, Luigi; Rausei, Stefano; Barczynski, Marcin; Tufano, Ralph P.; Kim, Hoon Yub; Anuwong, Angkoon

    2016-01-01

    In this video we describe transoral endoscopic thyroidectomy vestibular approach (TOETVA). Inclusion criteria are (I) patients who had a ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US estimated gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without evidence of metastasis. The procedure is carried out through three-port technique placed at the oral vestibule, one 10-mm port for 30° endoscope and two additional 5-mm ports for dissecting and coagulating instruments. CO2 insufflation pressure is set at 6 mmHg. An anterior cervical subplatysmal space is created from the oral vestibule down to the sternal notch, laterally to the sterncleidomuscles. Thyroidectomy is done fully endoscopically using conventional endoscopic instruments and intraoperative neuromonitoring (IONM). PMID:28149809

  12. Angular approach combined to mechanical model for tool breakage detection by eddy current sensors

    NASA Astrophysics Data System (ADS)

    Ritou, M.; Garnier, S.; Furet, B.; Hascoet, J. Y.

    2014-02-01

    The paper presents a new complete approach for Tool Condition Monitoring (TCM) in milling. The aim is the early detection of small damages so that catastrophic tool failures are prevented. A versatile in-process monitoring system is introduced for reliability concerns. The tool condition is determined by estimates of the radial eccentricity of the teeth. An adequate criterion is proposed combining mechanical model of milling and angular approach.Then, a new solution is proposed for the estimate of cutting force using eddy current sensors implemented close to spindle nose. Signals are analysed in the angular domain, notably by synchronous averaging technique. Phase shifts induced by changes of machining direction are compensated. Results are compared with cutting forces measured with a dynamometer table.The proposed method is implemented in an industrial case of pocket machining operation. One of the cutting edges has been slightly damaged during the machining, as shown by a direct measurement of the tool. A control chart is established with the estimates of cutter eccentricity obtained during the machining from the eddy current sensors signals. Efficiency and reliability of the method is demonstrated by a successful detection of the damage.

  13. Arthroscopic repair of combined Bankart and SLAP lesions: operative techniques and clinical results.

    PubMed

    Cho, Hyung Lae; Lee, Choon Key; Hwang, Tae Hyok; Suh, Kuen Tak; Park, Jong Won

    2010-03-01

    To evaluate the clinical results and operation technique of arthroscopic repair of combined Bankart and superior labrum anterior to posterior (SLAP) lesions, all of which had an anterior-inferior Bankart lesion that continued superiorly to include separation of the biceps anchor in the patients presenting recurrent shoulder dislocations. From May 2003 to January 2006, we reviewed 15 cases with combined Bankart and SLAP lesions among 62 patients with recurrent shoulder dislocations who underwent arthroscopic repair. The average age at surgery was 24.2 years (range, 16 to 38 years), with an average follow-up period of 15 months (range, 13 to 28 months). During the operation, we repaired the unstable SLAP lesion first with absorbable suture anchors and then also repaired Bankart lesion from the inferior to superior fashion. We analyzed the preoperative and postoperative results by visual analogue scale (VAS) for pain, the range of motion, American Shoulder and Elbow Surgeon (ASES) and Rowe shoulder scoring systems. We compared the results with the isolated Bankart lesion. VAS for pain was decreased from preoperative 4.9 to postoperative 1.9. Mean ASES and Rowe shoulder scores were improved from preoperative 56.4 and 33.7 to postoperative 91.8 and 94.1, respectively. There were no specific complication and no significant limitation of motion more than 10 degree at final follow-up. We found the range of motions after the arthroscopic repair in combined lesions were gained more slowly than in patients with isolated Bankart lesions. In recurrent dislocation of the shoulder with combined Bankart and SLAP lesion, arthroscopic repair using absorbable suture anchors produced favorable clinical results. Although it has technical difficulty, the concomitant unstable SLAP lesion should be repaired in a manner that stabilizes the glenohumeral joint, as the Bankart lesion can be repaired if the unstable SLAP lesion is repaired first.

  14. Arthroscopic Repair of Combined Bankart and SLAP Lesions: Operative Techniques and Clinical Results

    PubMed Central

    Cho, Hyung Lae; Lee, Choon Key; Hwang, Tae Hyok; Park, Jong Won

    2010-01-01

    Background To evaluate the clinical results and operation technique of arthroscopic repair of combined Bankart and superior labrum anterior to posterior (SLAP) lesions, all of which had an anterior-inferior Bankart lesion that continued superiorly to include separation of the biceps anchor in the patients presenting recurrent shoulder dislocations. Methods From May 2003 to January 2006, we reviewed 15 cases with combined Bankart and SLAP lesions among 62 patients with recurrent shoulder dislocations who underwent arthroscopic repair. The average age at surgery was 24.2 years (range, 16 to 38 years), with an average follow-up period of 15 months (range, 13 to 28 months). During the operation, we repaired the unstable SLAP lesion first with absorbable suture anchors and then also repaired Bankart lesion from the inferior to superior fashion. We analyzed the preoperative and postoperative results by visual analogue scale (VAS) for pain, the range of motion, American Shoulder and Elbow Surgeon (ASES) and Rowe shoulder scoring systems. We compared the results with the isolated Bankart lesion. Results VAS for pain was decreased from preoperative 4.9 to postoperative 1.9. Mean ASES and Rowe shoulder scores were improved from preoperative 56.4 and 33.7 to postoperative 91.8 and 94.1, respectively. There were no specific complication and no significant limitation of motion more than 10 degree at final follow-up. We found the range of motions after the arthroscopic repair in combined lesions were gained more slowly than in patients with isolated Bankart lesions. Conclusions In recurrent dislocation of the shoulder with combined Bankart and SLAP lesion, arthroscopic repair using absorbable suture anchors produced favorable clinical results. Although it has technical difficulty, the concomitant unstable SLAP lesion should be repaired in a manner that stabilizes the glenohumeral joint, as the Bankart lesion can be repaired if the unstable SLAP lesion is repaired first. PMID

  15. Improving operational anodising process performance using simulation approach

    SciTech Connect

    Liong, Choong-Yeun Ghazali, Syarah Syahidah

    2015-10-22

    The use of aluminium is very widespread, especially in transportation, electrical and electronics, architectural, automotive and engineering applications sectors. Therefore, the anodizing process is an important process for aluminium in order to make the aluminium durable, attractive and weather resistant. This research is focused on the anodizing process operations in manufacturing and supplying of aluminium extrusion. The data required for the development of the model is collected from the observations and interviews conducted in the study. To study the current system, the processes involved in the anodizing process are modeled by using Arena 14.5 simulation software. Those processes consist of five main processes, namely the degreasing process, the etching process, the desmut process, the anodizing process, the sealing process and 16 other processes. The results obtained were analyzed to identify the problems or bottlenecks that occurred and to propose improvement methods that can be implemented on the original model. Based on the comparisons that have been done between the improvement methods, the productivity could be increased by reallocating the workers and reducing loading time.

  16. Improving operational anodising process performance using simulation approach

    NASA Astrophysics Data System (ADS)

    Liong, Choong-Yeun; Ghazali, Syarah Syahidah

    2015-10-01

    The use of aluminium is very widespread, especially in transportation, electrical and electronics, architectural, automotive and engineering applications sectors. Therefore, the anodizing process is an important process for aluminium in order to make the aluminium durable, attractive and weather resistant. This research is focused on the anodizing process operations in manufacturing and supplying of aluminium extrusion. The data required for the development of the model is collected from the observations and interviews conducted in the study. To study the current system, the processes involved in the anodizing process are modeled by using Arena 14.5 simulation software. Those processes consist of five main processes, namely the degreasing process, the etching process, the desmut process, the anodizing process, the sealing process and 16 other processes. The results obtained were analyzed to identify the problems or bottlenecks that occurred and to propose improvement methods that can be implemented on the original model. Based on the comparisons that have been done between the improvement methods, the productivity could be increased by reallocating the workers and reducing loading time.

  17. Combined approaches to the skull base for intracranial extension of tumors via perineural spread can improve patient outcomes.

    PubMed

    Palejwala, Sheri K; Barry, Jonnae Y; Rodriguez, Crystal N; Parikh, Chandni A; Goldstein, Stephen A; Lemole, G Michael

    2016-11-01

    Many neoplasms of the head and neck extend centripetally, gaining access to the central nervous system via nerves through the skull base foramina. Often patients with perineural spread have been excluded from aggressive interventions given the overall poor prognosis and technical difficulty when addressing the perineural components. However, in carefully selected patients combined surgical approaches can provide the greatest potential for disease control as well as neural decompression for symptom relief. We performed a retrospective chart review of 20 consecutive patients who underwent skull base approaches for resection of tumors with intracranial extension via perineural spread from 2011 to 2014. Patients were evaluated for symptom change, surgical approaches, histopathology, adjuvant therapy, outcome, and prognosis. The most common presenting symptoms were pain or cranial nerve palsies. 55% of patients underwent endoscopic endonasal approaches, 50% transcranial approaches, and 15% underwent transfacial approaches. Overall 85% of patients reported symptom improvement in the post-operative period while 40% were completely asymptomatic following surgical resection. Ultimately, we observed a 45% mortality rate with an average survival of 8 months after diagnosis. In carefully selected patients, an aggressive multidisciplinary approach using a combination of surgical avenues to the skull base for the treatment of intracranial tumor via perineural extension can improve patient quality of life.

  18. Demirjian approach of dental age estimation: Abridged for operator ease

    PubMed Central

    Jain, Vanshika; Kapoor, Priyanka; Miglani, Ragini

    2016-01-01

    Background: Present times have seen an alarming increase in incidence of crimes by juveniles and of mass destruction that Highlight the preponderance of individual age estimation. Of the numerous techniques employed for age assessment, dental age estimation (DAE) and its correlation with chronological age (CA) have been of great significance in the recent past. Demirjian system, considered as gold standard in DAE is a simple and convenient method for DAE, though,, although, referring to multiple tables make it cumbersome and less eco friendly due to excessive paper load. Aim: The present study was aimed to develop a comprehensive chart (DAEcc) inclusive of all Demirjian tables and developmental stages of teeth and also to as well as to test the operator ease of 50 undergraduate dental students in performing DAE using this chart. Materials and Methods: The study was performed in two stages, wherein the first stage was aimed at formulation of the comprehensive chart (DAECC) which included pictorial representation of calcification stages, the Federation Dentaire Internationale notation of the teeth, and the corresponding scores for each stage with a concluding column at the end to enter the total score. The second stage assessed the applicability of the ease of DAE by DAECC, whereby fifty 2nd year BDS students were asked to trace the calcification stages of the seven permanent left mandibular teeth on a panorex, identify the correct stage, assign the corresponding score, and to calculate the total score for subsequent dental age assessment. Results and Conclusions: showed that average time taken by the students for tracing seven mandibular teeth was 5 min and for assessment of dental age was 7 min. The total time taken for DAE was approximately 12 min, thus making the procedure less time consuming. Hence, this study proposes the use of DAEcc for age estimation due to ease in comprehension and execution of Demirjian system. PMID:28123280

  19. An operational approach for infrasound multi-array processing

    NASA Astrophysics Data System (ADS)

    Vergoz, J.; Le Pichon, A.; Herry, P.; Blanc, E.

    2009-04-01

    The infrasound network of the International Monitoring Network (IMS) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) is currently not fully established. However, it has demonstrated its capability for detecting and locating infrasonic sources like meteorites as well as volcanic eruptions on a global scale. Unfortunately, such ground truth events are rare. Therefore, regions with dense infrasound networks have to be considered in order to test and calibrate detection and location procedures (Le Pichon. et al. 2008, J. Geophys. Res., 113, D12115, doi:10.1029/2007JD009509). In Central Europe, several years of continuous infrasound recordings are available for many infrasound arrays, where not all of them are part of the IMS. Infrasound waveforms are routinely processed in the 0.1 to 4 Hz frequency band using PMCC as a real-time detector. After applying a categorization procedure to remove detections associated with environmental noise, a blind fusion provides a list of events to be reviewed by the analyst. In order to check the geophysical consistency of the located events, an interactive tool has been developed. All results of the automatic processing are presented along with a realistic estimate of the network detection capability which incorporates near-real time atmospheric updates. Among the dominant acoustic sources of human origin, peaks in the geographical distribution of infrasound events correspond well with seismically active regions where operational mines have been identified. With the increasing number of IMS and regional cluster infrasound arrays deployed around the globe, conducting consistent analyses on a routine-basis provides an extensive database for discriminating between natural and artificial acoustic sources. Continuing such studies may also help quantifying relationships between infrasonic observables and atmospheric specification problems, thus opening new fields for investigations into inverse problems.

  20. Analysis of operational limit of an aircraft: An aeroelastic approach

    NASA Astrophysics Data System (ADS)

    Hasan, Md. Mehedi; Hassan, M. D. Mehedi; Sarrowar, S. M. Bayazid; Faisal, Kh. Md.; Ahmed, Sheikh Reaz, Dr.

    2017-06-01

    In classical theory of elasticity, external loading acting on the body is independent of deformation of the body. But, in aeroelasticity, aerodynamic forces depend on the attitude of the body relative to the flow. Aircraft's are subjected to a range of static loads resulting from equilibrium or steady flight maneuvers such as coordinated level turn, steady pitch and bank rate, steady and level flight. Interaction of these loads with elastic forces of aircraft structure creates some aeroelastic phenomena. In this paper, we have summarized recent developments in the area of aeroelasticity. A numerical approach has been applied for finding divergence speed, a static aeroelastic phenomena, of a typical aircraft. This paper also involves graphical representations of constraints on load factor and bank angle during different steady flight maneuvers taking flexibility into account and comparing it with the value without flexibility. Effect of wing skin thickness, spar web thickness and position of flexural axis of wing on this divergence speed as well as load factor and bank angle has also been observed using MATLAB.

  1. Experience in using three different minimally invasive approaches in cardiac operations.

    PubMed

    Wang, Wen Lin; Cai, Kai Can; Zeng, Wei Sheng; Jiang, Ren Chao

    2003-03-01

    In order to reach a clear understanding of minimally invasive approaches in cardiac operations, the authors review clinical experience in using three such approaches: inferior partial median sternotomy, right anterolateral minor thoracotomy, and the right parasternal approach. Sternotomy and the three different minimally invasive approaches were applied in and 2431 and 323 patients respectively. The approaches were selected according to the circumstances of the individual case. Both external and internal cardiac structures were observed during the operations. The length of the incision, the postoperative drainage, operative time, and cardiopulmonary bypass time were investigated. The postoperative complications occurring after minimally invasive approaches were observed. In inferior partial median sternotomy, all structures except for the ascending aorta could be exposed well. In right anterolateral minor thoracotomy, only the structures on the right side of the heart could be exposed, but the mitral valve could also be exposed well. The exposure of the right parasternal approach was similar to that of right anterolateral minor thoracotomy. There were statistically significant differences between sternotomy and the minimally invasive approaches in terms of incision length and postoperative drainage, but no difference in operative time and cardiopulmonary bypass time. The postoperative complications of MIAs included air embolism (n = 3), chest pain (n = 9), chest wall malacia (n = 1), rib fracture (n = 2), and sternum fracture (n = 2). The total incidence of complications in minimally invasive approaches was 5.3%. The minimally invasive approaches can have satisfactory clinical results if the approaches are correctly chosen and performed.

  2. Parallel point-multiplication architecture using combined group operations for high-speed cryptographic applications

    PubMed Central

    Saeedi, Ehsan; Kong, Yinan

    2017-01-01

    In this paper, we propose a novel parallel architecture for fast hardware implementation of elliptic curve point multiplication (ECPM), which is the key operation of an elliptic curve cryptography processor. The point multiplication over binary fields is synthesized on both FPGA and ASIC technology by designing fast elliptic curve group operations in Jacobian projective coordinates. A novel combined point doubling and point addition (PDPA) architecture is proposed for group operations to achieve high speed and low hardware requirements for ECPM. It has been implemented over the binary field which is recommended by the National Institute of Standards and Technology (NIST). The proposed ECPM supports two Koblitz and random curves for the key sizes 233 and 163 bits. For group operations, a finite-field arithmetic operation, e.g. multiplication, is designed on a polynomial basis. The delay of a 233-bit point multiplication is only 3.05 and 3.56 μs, in a Xilinx Virtex-7 FPGA, for Koblitz and random curves, respectively, and 0.81 μs in an ASIC 65-nm technology, which are the fastest hardware implementation results reported in the literature to date. In addition, a 163-bit point multiplication is also implemented in FPGA and ASIC for fair comparison which takes around 0.33 and 0.46 μs, respectively. The area-time product of the proposed point multiplication is very low compared to similar designs. The performance (1Area×Time=1AT) and Area × Time × Energy (ATE) product of the proposed design are far better than the most significant studies found in the literature. PMID:28459831

  3. Parallel point-multiplication architecture using combined group operations for high-speed cryptographic applications.

    PubMed

    Hossain, Md Selim; Saeedi, Ehsan; Kong, Yinan

    2017-01-01

    In this paper, we propose a novel parallel architecture for fast hardware implementation of elliptic curve point multiplication (ECPM), which is the key operation of an elliptic curve cryptography processor. The point multiplication over binary fields is synthesized on both FPGA and ASIC technology by designing fast elliptic curve group operations in Jacobian projective coordinates. A novel combined point doubling and point addition (PDPA) architecture is proposed for group operations to achieve high speed and low hardware requirements for ECPM. It has been implemented over the binary field which is recommended by the National Institute of Standards and Technology (NIST). The proposed ECPM supports two Koblitz and random curves for the key sizes 233 and 163 bits. For group operations, a finite-field arithmetic operation, e.g. multiplication, is designed on a polynomial basis. The delay of a 233-bit point multiplication is only 3.05 and 3.56 μs, in a Xilinx Virtex-7 FPGA, for Koblitz and random curves, respectively, and 0.81 μs in an ASIC 65-nm technology, which are the fastest hardware implementation results reported in the literature to date. In addition, a 163-bit point multiplication is also implemented in FPGA and ASIC for fair comparison which takes around 0.33 and 0.46 μs, respectively. The area-time product of the proposed point multiplication is very low compared to similar designs. The performance ([Formula: see text]) and Area × Time × Energy (ATE) product of the proposed design are far better than the most significant studies found in the literature.

  4. The Direct Anterior Approach for Complex Primary Total Hip Arthroplasty: The Extensile Acetabular Approach on a Regular Operating Room Table.

    PubMed

    Molenaers, Ben; Driesen, Ronald; Molenaers, Guy; Corten, Kristoff

    2017-05-01

    The direct anterior approach on a regular operating room table has been reported with low dislocation rates. This might be beneficial for complex primary total hip arthroplasty (THA) such as in patients with cerebral palsy or following femoral or pelvic osteotomies. Extending the approach is often required to overcome problems such as acetabular deformities or severe contractures. We retrospectively evaluated the results and complications of 29 patients with 37 complex primary THA in which an extensile approach was used. The extensile approach is described. Functional scores were collected in case the patient was ambulatory independently (n = 17). The average age was 35 years (range 15-85) with a mean follow-up of 39 months (range 12-60). There were 3 (8%) intra-operative and 4 (11%) early post-operative complications (<3 months), of which 3 (8%) were anterior dislocations. Late complications (>3 months) consisted of a fibrous ingrown stem, a socket loosening following a pelvic fracture, and a late hematogenous infection (8%). Seventy-one percent of the complications occurred in the first 18 cases (49%) indicating a learning curve. The mean post-operative Harris Hip Score was 79 (range 56-97). Complex THA can be safely conducted through the extensile anterior approach on a regular operating room table with the use of conventional implants, even in cases with a high risk of dislocation. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Operational decision support system for large combined sewage systems: Lisbon/Tagus estuary case study.

    PubMed

    Póvoa, P; Nobre, A; Leitão, P; Galvão, P; Santos, H; Frazão, A; Neves, R; Matos, J S

    2015-01-01

    Managing combined sewage systems in large cities discharging to coastal waters, often bearing recreational activities, remains a challenge. Studying the impacts of such discharges requires the development of specific models. Hydrodynamic and water quality modelling of coastal waters employs numerical methods and algorithms, leading to the design of complex models which require expert use. The use of such models as decision support tools to simulate discharge impacts and define adequate corrective measures could represent a key part in meeting this challenge. In this paper, the authors describe the work undertaken to develop an operational decision support system (ODSS) methodology aiming to enable wastewater utilities' non-expert staff to carry out user-friendly scenario analysis based on computational fluid dynamics simulations. This article depicts the application and validation of the ODSS to the combined sewage system and the Tagus estuary of the city of Lisbon in Portugal. The ODSS was used for simulating the effects in the receiving coastal waters of a discharge caused by a scheduled maintenance operation in the sewage infrastructure. Results show that the use of such ODSS by non-expert staff increases their decision capabilities and knowledge of the wastewater utility's contribution to reducing negative impacts of sewage discharges on the receiving water bodies.

  6. Primary stentriever versus combined stentriever plus aspiration thrombectomy approaches: in vitro stroke model comparison

    PubMed Central

    Mokin, Maxim; Ionita, Ciprian N; Nagesh, Swetadri Vasan Setlur; Rudin, Stephen; Levy, Elad I; Siddiqui, Adnan H

    2014-01-01

    Background Artificial stroke models can be used for testing various thrombectomy devices. Objective To determine the value of combined stentriever–aspiration thrombectomy compared with the stentriever-alone approach. Methods We designed an in vitro model of the intracranial circulation with a focus on the middle cerebral artery (MCA) that closely resembles the human intracranial circulation. After introducing fresh clot in the MCA, we used conventional biplane angiography and microangiographic fluoroscopy to compare recanalization rates and occurrence of emboli in new, unaffected territory for thrombectomy approaches in which a stentriever (Solitaire flow restoration stentriever, Covidien) was used alone or in combination with continuous manual aspiration through a Navien catheter (Covidien). Results In a total of 22 experiments (11 for each approach), successful clot delivery to the MCA was achieved in all cases. Successful angiographic recanalization (thrombolysis in cerebral infarction score of 2b–3) was achieved more frequently with the combined stentriever–aspiration approach than with the stentriever-alone approach (in 10 vs 4 experiments, p=0.023). Emboli in new territory occurred in three experiments with the stentriever-alone approach, and none were seen with the combined approach (p=0.21). Conclusions The combined stentriever–aspiration approach to thrombectomy leads to better angiographic recanalization rates than use of the stentriever alone. Further experiments are needed to test the value of balloon-guide catheters and aspiration performed using other types of catheters and modes of aspiration. PMID:24789594

  7. A strategic planning approach for operational-environmental tradeoff assessments in terminal areas

    NASA Astrophysics Data System (ADS)

    Jimenez, Hernando

    of fuel burn, emissions, and noise. The implementation of the proposed approach for the assessment of terminal area solutions incorporates the use of discrete response surface equations, and eliminates the use of quadratic terms that have no practical significance in this context. Rather, attention is entire placed on the main effects of different terminal area solutions, namely additional airport infrastructure, operational improvements, and advanced aircraft concepts, modeled as discrete independent variables for the regression model. Results reveal that an additional runway and a new international terminal, as well as reduced aircraft separation, have a major effect on all operational metrics of interest. In particular, the additional runway has a dominant effect for departure delay metrics and gate hold periods, with moderate interactions with respect to separation reduction. On the other hand, operational metrics for arrivals are co-dependent on additional infrastructure and separation reduction, featuring marginal improvements whenever these two solutions are implemented in isolation, but featuring a dramatic compounding effect when implemented in combination. The magnitude of these main effects for departures and of the interaction between these solutions for arrivals is confirmed through appropriate statistical significance testing. Finally, the inclusion o advanced aircraft concepts is shown to be most beneficial for airborne arrival operations and to a lesser extent for arrival ground movements. More specifically, advanced aircraft concepts were found to be primarily responsible for reductions in volatile organic compounds, unburned hydrocarbons, and particulate matter in this flight regime, but featured relevant interactions with separation reduction and additional airport infrastructure. To address the selection of scenarios for strategic airport planning, a technique for risk-based scenario construction, evaluation, and selection is proposed

  8. Combined Transzygomatic and Pterional Approach for Resection of a Dermoid Cyst of the Foreman Ovale.

    PubMed

    Riordan, Margaret; Klosterman, Tristan; Kellman, Robert; Chin, Lawrence

    2016-03-01

    Dermoid cysts are rare, benign intracranial lesions commonly located in the posterior fossa. We describe a uniquely located dermoid cyst in the foreman ovale resected via a combined pterional and transzygomatic approach. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Optimal operating rules definition in complex water resource systems combining fuzzy logic, expert criteria and stochastic programming

    NASA Astrophysics Data System (ADS)

    Macian-Sorribes, Hector; Pulido-Velazquez, Manuel

    2016-04-01

    This contribution presents a methodology for defining optimal seasonal operating rules in multireservoir systems coupling expert criteria and stochastic optimization. Both sources of information are combined using fuzzy logic. The structure of the operating rules is defined based on expert criteria, via a joint expert-technician framework consisting in a series of meetings, workshops and surveys carried out between reservoir managers and modelers. As a result, the decision-making process used by managers can be assessed and expressed using fuzzy logic: fuzzy rule-based systems are employed to represent the operating rules and fuzzy regression procedures are used for forecasting future inflows. Once done that, a stochastic optimization algorithm can be used to define optimal decisions and transform them into fuzzy rules. Finally, the optimal fuzzy rules and the inflow prediction scheme are combined into a Decision Support System for making seasonal forecasts and simulate the effect of different alternatives in response to the initial system state and the foreseen inflows. The approach presented has been applied to the Jucar River Basin (Spain). Reservoir managers explained how the system is operated, taking into account the reservoirs' states at the beginning of the irrigation season and the inflows previewed during that season. According to the information given by them, the Jucar River Basin operating policies were expressed via two fuzzy rule-based (FRB) systems that estimate the amount of water to be allocated to the users and how the reservoir storages should be balanced to guarantee those deliveries. A stochastic optimization model using Stochastic Dual Dynamic Programming (SDDP) was developed to define optimal decisions, which are transformed into optimal operating rules embedding them into the two FRBs previously created. As a benchmark, historical records are used to develop alternative operating rules. A fuzzy linear regression procedure was employed to

  10. Combined Grinding and Drying of Biomass in One Operation Phase I

    SciTech Connect

    Sokhansanj, S

    2008-06-26

    First American Scientific Corporation (FASC) has developed a unique and innovative grinder/dryer called KDS Micronex. The KS (Kinetic Disintegration System) combines two operations of grinding and drying into a single operation which reduces dependence on external heat input. The machine captures the heat of comminution and combines it will centrifugal forces to expedite moisture extraction from wet biomass. Because it uses mechanical forces rather than providing direct heat to perform the drying operation, it is a simpler machine and uses less energy than conventional grinding and drying operations which occur as two separate steps. The entire compact unit can be transported on a flatbed trailer to the site where biomass is available. Hence, the KDS Micronex is a technology that enables inexpensive pretreatment of waste materials and biomass. A well prepared biomass can be used as feed, fuel or fertilizer instead of being discarded. Electricity and chemical feedstock produced from such biomass would displace the use of fossil fuels and no net greenhouse gas emissions would result from such bio-based operations. Organic fertilizers resulting from the KS Micronex grinding/drying process will be pathogen-free unlike raw animal manures. The feasibility tests on KS during Phase I showed that a prototype machine can be developed, field tested and the technology demonstrated for commercial applications. The present KDS machine can remove up to 400 kg/h of water from a wet feed material. Since biomass processors demand a finished product that is only 10% moist and most raw materials like corn stover, bagasse, layer manure, cow dung, and waste wood have moisture contents of the order of 50%, this water removal rate translates to a production rate of roughly half a ton per hour. this is too small for most processors who are unwilling to acquire multiple machines because of the added complexity to the feed and product removal systems. The economics suffer due to small

  11. Performance and operational economics estimates for a coal gasification combined-cycle cogeneration powerplant

    NASA Astrophysics Data System (ADS)

    Nainiger, J. J.; Burns, R. K.; Easley, A. J.

    1982-03-01

    A performance and operational economics analysis is presented for an integrated-gasifier, combined-cycle (IGCC) system to meet the steam and baseload electrical requirements. The effect of time variations in steam and electrial requirements is included. The amount and timing of electricity purchases from sales to the electric utility are determined. The resulting expenses for purchased electricity and revenues from electricity sales are estimated by using an assumed utility rate structure model. Cogeneration results for a range of potential IGCC cogeneration system sizes are compared with the fuel consumption and costs of natural gas and electricity to meet requirements without cogeneration. The results indicate that an IGCC cogeneration system could save about 10 percent of the total fuel energy presently required to supply steam and electrical requirements without cogeneration. Also for the assumed future fuel and electricity prices, an annual operating cost savings of 21 percent to 26 percent could be achieved with such a cogeneration system. An analysis of the effects of electricity price, fuel price, and system availability indicates that the IGCC cogeneration system has a good potential for economical operation over a wide range in these assumptions.

  12. Performance and operational economics estimates for a coal gasification combined-cycle cogeneration powerplant

    NASA Technical Reports Server (NTRS)

    Nainiger, J. J.; Burns, R. K.; Easley, A. J.

    1982-01-01

    A performance and operational economics analysis is presented for an integrated-gasifier, combined-cycle (IGCC) system to meet the steam and baseload electrical requirements. The effect of time variations in steam and electrial requirements is included. The amount and timing of electricity purchases from sales to the electric utility are determined. The resulting expenses for purchased electricity and revenues from electricity sales are estimated by using an assumed utility rate structure model. Cogeneration results for a range of potential IGCC cogeneration system sizes are compared with the fuel consumption and costs of natural gas and electricity to meet requirements without cogeneration. The results indicate that an IGCC cogeneration system could save about 10 percent of the total fuel energy presently required to supply steam and electrical requirements without cogeneration. Also for the assumed future fuel and electricity prices, an annual operating cost savings of 21 percent to 26 percent could be achieved with such a cogeneration system. An analysis of the effects of electricity price, fuel price, and system availability indicates that the IGCC cogeneration system has a good potential for economical operation over a wide range in these assumptions.

  13. Hybrid treatment for complex aortic problems combining surgery and stenting in the integrated operating theater.

    PubMed

    Brueck, Martin; Heidt, Martin C; Szente-Varga, Michael; Bandorski, Dirk; Kramer, Wilfried; Vogt, Paul R

    2006-12-01

    Conventional surgical treatment of complex aortic pathologies involving several thoracoabdominal aortic segments necessitates extended incisions or subsequent surgeries, resulting in significant mortality and morbidity rates. The combination of surgery and simultaneous stenting in the operating theater may reduce the surgical trauma. A total of nine patients (62 +/- 10 years, range 44-70) underwent a combined surgical and endovascular treatment of thoracic or thoracoabdominal aortic aneurysms or chronic dissection. Five patients were treated with viscero-renal artery translocation followed by transfemoral stenting of the entire thoracoabdominal aorta. Two patients underwent debranching of the supraaortic vessels followed by immediate transfemoral stenting of the aortic arch, and two patients with a history of an ascending aortic aneurysm repair were treated with open surgical debranching of the supraaortic trunks and repair of the ascending aorta and aortic arch with elephant trunk technique. Preoperatively, magnetic resonance imaging was used to check supraaortic and intracranial vessels as well as the completeness of the Circle of Willisi prior to arch stenting and/or supraaortic vessel surgery. Cerebrospinal fluid drainage and induced mild hypertension have been used for one-step thoracoabdominal aortic stenting. Thirty-day mortality rate and incidence of paraplegia was 0%. There was a single reversible perioperative stroke after aortic arch stenting. One patient required temporary renal replacement therapy using continuous arterio-venous hemofiltration. There was one early reoperation at the superior mesenteric artery after viscero-renal translocation. Four type I endoleaks occurred in three patients requiring two interventions. All patients have been discharged to home. The innovative combination of simultaneous conventional surgery and stenting reduces the operative burden for patients with complex aortic pathologies involving several segments of the thoracic

  14. A combined triggering-propagation modeling approach for the assessment of rainfall induced debris flow susceptibility

    NASA Astrophysics Data System (ADS)

    Stancanelli, Laura Maria; Peres, David Johnny; Cancelliere, Antonino; Foti, Enrico

    2017-07-01

    Rainfall-induced shallow slides can evolve into debris flows that move rapidly downstream with devastating consequences. Mapping the susceptibility to debris flow is an important aid for risk mitigation. We propose a novel practical approach to derive debris flow inundation maps useful for susceptibility assessment, that is based on the integrated use of DEM-based spatially-distributed hydrological and slope stability models with debris flow propagation models. More specifically, the TRIGRS infiltration and infinite slope stability model and the FLO-2D model for the simulation of the related debris flow propagation and deposition are combined. An empirical instability-to-debris flow triggering threshold calibrated on the basis of observed events, is applied to link the two models and to accomplish the task of determining the amount of unstable mass that develops as a debris flow. Calibration of the proposed methodology is carried out based on real data of the debris flow event occurred on 1 October 2009, in the Peloritani mountains area (Italy). Model performance, assessed by receiver-operating-characteristics (ROC) indexes, evidences fairly good reproduction of the observed event. Comparison with the performance of the traditional debris flow modeling procedure, in which sediment and water hydrographs are inputed as lumped at selected points on top of the streams, is also performed, in order to assess quantitatively the limitations of such commonly applied approach. Results show that the proposed method, besides of being more process-consistent than the traditional hydrograph-based approach, can potentially provide a more accurate simulation of debris-flow phenomena, in terms of spatial patterns of erosion and deposition as well on the quantification of mobilized volumes and depths, avoiding overestimation of debris flow triggering volume and, thus, of maximum inundation flow depths.

  15. Rational-operator-based depth-from-defocus approach to scene reconstruction.

    PubMed

    Li, Ang; Staunton, Richard; Tjahjadi, Tardi

    2013-09-01

    This paper presents a rational-operator-based approach to depth from defocus (DfD) for the reconstruction of three-dimensional scenes from two-dimensional images, which enables fast DfD computation that is independent of scene textures. Two variants of the approach, one using the Gaussian rational operators (ROs) that are based on the Gaussian point spread function (PSF) and the second based on the generalized Gaussian PSF, are considered. A novel DfD correction method is also presented to further improve the performance of the approach. Experimental results are considered for real scenes and show that both approaches outperform existing RO-based methods.

  16. Computational Analysis for Rocket-Based Combined-Cycle Systems During Rocket-Only Operation

    NASA Technical Reports Server (NTRS)

    Steffen, C. J., Jr.; Smith, T. D.; Yungster, S.; Keller, D. J.

    2000-01-01

    A series of Reynolds-averaged Navier-Stokes calculations were employed to study the performance of rocket-based combined-cycle systems operating in an all-rocket mode. This parametric series of calculations were executed within a statistical framework, commonly known as design of experiments. The parametric design space included four geometric and two flowfield variables set at three levels each, for a total of 729 possible combinations. A D-optimal design strategy was selected. It required that only 36 separate computational fluid dynamics (CFD) solutions be performed to develop a full response surface model, which quantified the linear, bilinear, and curvilinear effects of the six experimental variables. The axisymmetric, Reynolds-averaged Navier-Stokes simulations were executed with the NPARC v3.0 code. The response used in the statistical analysis was created from Isp efficiency data integrated from the 36 CFD simulations. The influence of turbulence modeling was analyzed by using both one- and two-equation models. Careful attention was also given to quantify the influence of mesh dependence, iterative convergence, and artificial viscosity upon the resulting statistical model. Thirteen statistically significant effects were observed to have an influence on rocket-based combined-cycle nozzle performance. It was apparent that the free-expansion process, directly downstream of the rocket nozzle, can influence the Isp efficiency. Numerical schlieren images and particle traces have been used to further understand the physical phenomena behind several of the statistically significant results.

  17. Physical Properties as Modal Operators in the Topos Approach to Quantum Mechanics

    NASA Astrophysics Data System (ADS)

    Freytes, H.; Domenech, G.; de Ronde, C.

    2014-12-01

    In the framework of the topos approach to quantum mechanics we give a representation of physical properties in terms of modal operators on Heyting algebras. It allows us to introduce a classical type study of the mentioned properties.

  18. Efficient Nonparametric Approaches for Estimating the Operating Characteristics of Discrete Item Responses.

    ERIC Educational Resources Information Center

    Samejima, Fumiko

    1998-01-01

    Introduces and discusses the rationale and procedures of two nonparametric approaches to estimating the operating characteristic of a discrete item response, or the conditional probability, given the latent trait, that the examinee's response be that specific response. (SLD)

  19. Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development.

    PubMed

    Ocana, Alberto; Pandiella, Atanasio

    2017-01-01

    Preclinical evaluation of drug combinations is challenging. In this mini-review we discuss the concept of synthetic lethality and how this can impact on the evaluation of drug combinations and its clinical development. We will also review novel combinations with immunologic agents and the concept of collateral lethality. We suggest that identification of synthetic lethality interactions including collateral lethality using novel drug combinations can speed up the drug development process. This approach may identify synergistic combinations in tumors with a specific molecular alteration, limiting toxicity to normal tissue. In addition, the combination of an immunotherapy with an agent targeting cancer cells have the potential for acting on different functions with no overlapping of toxicities. Here, we also discuss potential consequences of this approach in the design of early clinical studies.

  20. Phase-space representation of quantum state vectors: The relative-state approach and the displacement-operator approach

    NASA Astrophysics Data System (ADS)

    Ban, Masashi

    1999-08-01

    Phase-space representation of quantum state vectors has been recently formulated by means of the relative-state method developed by the present author [J. Math. Phys. 39, 1744 (1998)]. It is, however, pointed out by Mo/ller that the displacement-operator method provides another basis of phase-space representation of quantum state vectors [J. Math. Phys. (to appear)]. Hence the relation between the relative-state approach and the displacement-operator approach is discussed, both of which yield equivalent phase-space representations.

  1. Workspace design for crane cabins applying a combined traditional approach and the Taguchi method for design of experiments.

    PubMed

    Spasojević Brkić, Vesna K; Veljković, Zorica A; Golubović, Tamara; Brkić, Aleksandar Dj; Kosić Šotić, Ivana

    2016-01-01

    Procedures in the development process of crane cabins are arbitrary and subjective. Since approximately 42% of incidents in the construction industry are linked to them, there is a need to collect fresh anthropometric data and provide additional recommendations for design. In this paper, dimensioning of the crane cabin interior space was carried out using a sample of 64 crane operators' anthropometric measurements, in the Republic of Serbia, by measuring workspace with 10 parameters using nine measured anthropometric data from each crane operator. This paper applies experiments run via full factorial designs using a combined traditional and Taguchi approach. The experiments indicated which design parameters are influenced by which anthropometric measurements and to what degree. The results are expected to be of use for crane cabin designers and should assist them to design a cabin that may lead to less strenuous sitting postures and fatigue for operators, thus improving safety and accident prevention.

  2. Using Response Surface Methodology as an Approach to Understand and Optimize Operational Air Power

    DTIC Science & Technology

    2010-01-01

    Introduction to Taguchi Methodology . In Taguchi Methods : Proceedings of the 1988 European Conference, 1-14. London: Elsevier Applied Science. Box G. E. and N... Methodology As an Approach to Understand and Optimize Operational Air Power Marvin L. Simpson, Jr. Resit Unal Report Documentation Page Form...00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE Using Response Surface Methodology As an Approach to Understand and Optimize Operational Air Power

  3. Orbiter/payload proximity operations SES Postsim report. Lateral approach and other techniques

    NASA Technical Reports Server (NTRS)

    Olszewski, O.

    1978-01-01

    Various approach and stationkeeping simulations (proximity operations) were conducted in the Shuttle engineering simulator (SES). This simulator is the first to dynamically include the Orbiter reaction control system (RCS) plume effects on a payload being recovered after rendezvous operations. A procedure for braking, using the simultaneous firing of both jets, was evaluated and found very useful for proximity operations. However this procedure is very inefficient in the RCS usage and requires modifications to the digital autopilot (DAP) software. A new final approach, the lateral approach technique (LAT), or the momentum vector proximity approach, was also evaluated in the simulations. The LAT, which included a tailfirst approach for braking, was evaluated successfully with both inertial and gravity stabilized payloads.

  4. Use of combined biogeochemical model approaches and empirical data to assess critical loads of nitrogen

    Treesearch

    Mark Fenn; Charles Driscoll; Quingtao Zhou; Leela Rao; Thomas Meixner; Edith Allen; Fengming Yuan; Timothy Sullivan

    2015-01-01

    Empirical and dynamic biogeochemical modelling are complementary approaches for determining the critical load (CL) of atmospheric nitrogen (N) or other constituent deposition that an ecosystem can tolerate without causing ecological harm. The greatest benefits are obtained when these approaches are used in combination. Confounding environmental factors can complicate...

  5. Occupational therapists prefer combining multiple intervention approaches for children with learning difficulties.

    PubMed

    Nelson, Alison; Copley, Jodie; Flanigan, Kerry; Underwood, Katherine

    2009-02-01

    Research to date has not fully explored how occupational therapists provide intervention for children with learning difficulties in their day-to-day practice. The purpose of this study was to provide an in-depth description of the approaches and techniques used and how they are applied and combined to meet the complex and multifaceted needs of these children. In-depth interviews and short questionnaires were completed by seven occupational therapists who had provided intervention to children with learning difficulties. Observations of therapy sessions were also conducted. Thematic analysis gained insight into the approaches and techniques therapists used and how these were applied in practice. Therapists use a wide range of approaches in various combinations because they feel that these best meet the needs of individual children. Sensory-based and cognitive approaches were most frequently drawn from and combined with other approaches such as visual information analysis, biomechanical and psychosocial approaches added for particular purposes. Approaches were usually combined simultaneously within an activity or session. Therapists create their own 'multimodel' approach in order to best meet the needs of their clients. They are able to articulate the theoretical basis behind these choices, although lack of clarity exists about the frames of reference being used.

  6. Using Vision System Technologies for Offset Approaches in Low Visibility Operations

    NASA Technical Reports Server (NTRS)

    Kramer, Lynda J.; Bailey, Randall E.; Ellis, Kyle K.

    2015-01-01

    Flight deck-based vision systems, such as Synthetic Vision Systems (SVS) and Enhanced Flight Vision Systems (EFVS), have the potential to provide additional margins of safety for aircrew performance and enable the implementation of operational improvements for low visibility surface, arrival, and departure operations in the terminal environment with equivalent efficiency to visual operations. Twelve air transport-rated crews participated in a motion-base simulation experiment to evaluate the use of SVS/EFVS in Next Generation Air Transportation System low visibility approach and landing operations at Chicago O'Hare airport. Three monochromatic, collimated head-up display (HUD) concepts (conventional HUD, SVS HUD, and EFVS HUD) and three instrument approach types (straight-in, 3-degree offset, 15-degree offset) were experimentally varied to test the efficacy of the SVS/EFVS HUD concepts for offset approach operations. The findings suggest making offset approaches in low visibility conditions with an EFVS HUD or SVS HUD appear feasible. Regardless of offset approach angle or HUD concept being flown, all approaches had comparable ILS tracking during the instrument segment and were within the lateral confines of the runway with acceptable sink rates during the visual segment of the approach. Keywords: Enhanced Flight Vision Systems; Synthetic Vision Systems; Head-up Display; NextGen

  7. Empowering Sustained Patient Safety: The Benefits of Combining Top-down and Bottom-up Approaches.

    PubMed

    Stewart, Greg L; Manges, Kirstin A; Ward, Marcia M

    2015-01-01

    Implementation of TeamSTEPPS for improving patient safety is examined via descriptive qualitative analysis of semistructured interviews with 21 informants at 12 hospitals. Implementation approaches fit 3 strategies: top-down, bottom-up, and combination. The top-down approach failed to develop enough commitment to spread implementation. The bottom-up approach was unable to marshal the resources necessary to spread implementation. Combining top-down and bottom-up processes best facilitated the implementation and spread of the TeamSTEPPS safety initiative.

  8. Philosophy for operation of distribution system automation schemes: ACTEW`s approach

    SciTech Connect

    Cornell, J.

    1995-12-31

    ACTEW Corp has embarked on a series of pilot remote control and operations schemes to evaluate potential DSA operational philosophies in the national capital city of Australia, Canberra. In commercial districts which essentially comprise ring main unit connected underground circuits with some tee`d cross connections, ACTEW (in partnership with private engineers) is developing a network of actuator-operated switches controlled via VHF radio-, or Trunked Radio-, linked RTU`s. Domestic districts are reticulated by feeders which combine multiple-interspersed overhead and underground sections. To automate this arrangement, the philosophy must accommodate this diversity of circuitry and is being addressed by a combination of pole-mounted switches (on the overhead sections) and actuator operated switches on the underground sections. All operating philosophies are being trialed in a remote control mode before full automation is attempted.

  9. Why Do Fearful Facial Expressions Elicit Behavioral Approach? Evidence From a Combined Approach-Avoidance Implicit Association Test

    PubMed Central

    Hammer, Jennifer L.; Marsh, Abigail A.

    2015-01-01

    Despite communicating a “negative” emotion, fearful facial expressions predominantly elicit behavioral approach from perceivers. It has been hypothesized that this seemingly paradoxical effect may occur due to fearful expressions’ resemblance to vulnerable, infantile faces. However, this hypothesis has not yet been tested. We used a combined approach-avoidance/implicit association test (IAT) to test this hypothesis. Participants completed an approach-avoidance lever task during which they responded to fearful and angry facial expressions as well as neutral infant and adult faces presented in an IAT format. Results demonstrated an implicit association between fearful facial expressions and infant faces and showed that both fearful expressions and infant faces primarily elicit behavioral approach. The dominance of approach responses to both fearful expressions and infant faces decreased as a function of psychopathic personality traits. Results suggest that the prosocial responses to fearful expressions observed in most individuals may stem from their associations with infantile faces. PMID:25603135

  10. Why do fearful facial expressions elicit behavioral approach? Evidence from a combined approach-avoidance implicit association test.

    PubMed

    Hammer, Jennifer L; Marsh, Abigail A

    2015-04-01

    Despite communicating a "negative" emotion, fearful facial expressions predominantly elicit behavioral approach from perceivers. It has been hypothesized that this seemingly paradoxical effect may occur due to fearful expressions' resemblance to vulnerable, infantile faces. However, this hypothesis has not yet been tested. We used a combined approach-avoidance/implicit association test (IAT) to test this hypothesis. Participants completed an approach-avoidance lever task during which they responded to fearful and angry facial expressions as well as neutral infant and adult faces presented in an IAT format. Results demonstrated an implicit association between fearful facial expressions and infant faces and showed that both fearful expressions and infant faces primarily elicit behavioral approach. The dominance of approach responses to both fearful expressions and infant faces decreased as a function of psychopathic personality traits. Results suggest that the prosocial responses to fearful expressions observed in most individuals may stem from their associations with infantile faces. (PsycINFO Database Record

  11. 14 CFR 121.659 - Initial approach altitude: Domestic and supplemental operations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Initial approach altitude: Domestic and... Flight Release Rules § 121.659 Initial approach altitude: Domestic and supplemental operations. (a... navigation facility under IFR, no person may descend an aircraft below the pertinent minimum altitude...

  12. 14 CFR 121.659 - Initial approach altitude: Domestic and supplemental operations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Initial approach altitude: Domestic and... Flight Release Rules § 121.659 Initial approach altitude: Domestic and supplemental operations. (a... navigation facility under IFR, no person may descend an aircraft below the pertinent minimum altitude...

  13. 14 CFR 121.659 - Initial approach altitude: Domestic and supplemental operations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Initial approach altitude: Domestic and... Flight Release Rules § 121.659 Initial approach altitude: Domestic and supplemental operations. (a... navigation facility under IFR, no person may descend an aircraft below the pertinent minimum altitude...

  14. An End-User Approach to Using Microcomputers in Teaching Production/Operations Management.

    ERIC Educational Resources Information Center

    Luebbe, Richard L.; Finch, Byron J.

    1989-01-01

    Advocates using an end-user approach to microcomputers in production/operations management. This approach requires the student to design and create spreadsheet models to solve problems, enhancing subject area knowledge, creativity, and problem-solving and computer skills. (SK)

  15. Combined solar thermal and photovoltaic power plants - An approach to 24h solar electricity?

    NASA Astrophysics Data System (ADS)

    Platzer, Werner J.

    2016-05-01

    Solar thermal power plants have the advantage of being able to provide dispatchable renewable electricity even when the sun is not shining. Using thermal energy strorage (TES) they may increase the capacity factor (CF) considerably. However in order to increase the operating hours one has to increase both, thermal storage capacity and solar field size, because the additional solar field is needed to charge the storage. This increases investment cost, although levelised electricity cost (LEC) may decrease due to the higher generation. Photovoltaics as a fluctuating source on the other side has arrived at very low generation costs well below 10 ct/kWh even for Central Europe. Aiming at a capacity factor above 70% and at producing dispatchable power it is shown that by a suitable combination of CSP and PV we can arrive at lower costs than by increasing storage and solar field size in CSP plants alone. Although a complete baseload power plant with more than 90% full load hours may not be the most economic choice, power plants approaching a full 24h service in most days of the year seem to be possible at reasonably low tariffs.

  16. Combined pars plana and limbal approach for removal of congenital cataracts.

    PubMed

    Liu, Xin; Luo, Yi; Zhou, Xingtao; Jiang, Lin; Zhou, Peng; Lu, Yi

    2012-12-01

    We describe a combined pars plana-limbal approach using a 25-gauge transconjunctival sutureless vitrectomy system for removal of congenital cataracts in a 5-month-old boy. The operated eye had anterior capsulotomy, lensectomy, posterior capsulotomy, and anterior vitrectomy through a pars plana transconjunctival incision created with a 25-gauge trocar. A limbal port incision was used to introduce an infusion micro cannula to maintain the anterior chamber. Incisions did not require suture closure. Following the procedure, inflammation was mild, the pupil was circular and centric, and the intraocular pressure (IOP) was stable. The eyes were left aphakic, and vision was corrected with spectacles. Amblyopia treatment ensued. This surgical technique appears to be safe and effective for the removal of congenital cataracts. Advantages include a more precise capsulotomy and more sufficient lensectomy and anterior vitrectomy, stable intraoperative IOP, and reduced surgical trauma and inflammation. No author has a financial or proprietary interest in any material or method mentioned. Copyright © 2012 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

  17. Operating Conditions of a Three-stage Combined Power Cycle using Cold Energy for Maximizing Exergetic Efficiency

    NASA Astrophysics Data System (ADS)

    Miyazaki, Takahiko; Akisawa, Atsushi; Kashiwagi, Takao

    Waste heat utilization is a fundamental approach to end-use energy savings. Medium or low temperature waste heat is not usable unless its temperature level matches the demand. From this standpoint, power generation from medium or low temperature waste heat is beneficial because it improves the availability of the energy by converting waste heat into electricity or mechanical work. Conventional waste heat driven power generation cycles, such as the Kalina cycle, attain relatively low thermal efficiencies because of the low exergy in medium or low temperature heat. This paper proposes a three-stage combined power cycle using cold energy for power generation from medium temperature (≅200°C)waste heat. The system consists of an ammonia-water Rankine cycle, an ethane-propane Rankine cycle and a liquefied natural gas direct expansion cycle. A cycle simulation of the system is executed, and the operating conditions where the exergetic efficiency is maximized are presented in this article. It is found that the exergetic efficiency reaches 31% under these operating conditions.

  18. Analysis of a Rocket Based Combined Cycle Engine during Rocket Only Operation

    NASA Technical Reports Server (NTRS)

    Smith, T. D.; Steffen, C. J., Jr.; Yungster, S.; Keller, D. J.

    1998-01-01

    The all rocket mode of operation is a critical factor in the overall performance of a rocket based combined cycle (RBCC) vehicle. However, outside of performing experiments or a full three dimensional analysis, there are no first order parametric models to estimate performance. As a result, an axisymmetric RBCC engine was used to analytically determine specific impulse efficiency values based upon both full flow and gas generator configurations. Design of experiments methodology was used to construct a test matrix and statistical regression analysis was used to build parametric models. The main parameters investigated in this study were: rocket chamber pressure, rocket exit area ratio, percent of injected secondary flow, mixer-ejector inlet area, mixer-ejector area ratio, and mixer-ejector length-to-inject diameter ratio. A perfect gas computational fluid dynamics analysis was performed to obtain values of vacuum specific impulse. Statistical regression analysis was performed based on both full flow and gas generator engine cycles. Results were also found to be dependent upon the entire cycle assumptions. The statistical regression analysis determined that there were five significant linear effects, six interactions, and one second-order effect. Two parametric models were created to provide performance assessments of an RBCC engine in the all rocket mode of operation.

  19. Quantum Hall conductance of graphene combined with charge-trap memory operation.

    PubMed

    Kang, Haeyong; Yun, Yoojoo; Park, Jeongmin; Kim, Joonggyu; Truong, Thuy Kieu; Kim, Jeong-Gyun; Park, Nahee; Yun, Hoyeol; Lee, Sang Wook; Lee, Young Hee; Suh, Dongseok

    2015-08-28

    The combination of quantum Hall conductance and charge-trap memory operation was qualitatively examined using a graphene field-effect transistor. The characteristics of two terminal quantum Hall conductance appeared clearly on the background of a huge conductance hysteresis during a gate-voltage sweep for a device using monolayer graphene as a channel,hexagonal boron-nitride flakes as a tunneling dielectric and defective silicon oxide as the charge storage node. Even though there was a giant shift of the charge neutrality point, the deviation of quantized resistance value at the state of filling factor 2 was less than 1.6% from half of the von Klitzing constant. At high Landau level indices, the behaviors of quantum conductance oscillation between the increasing and the decreasing electron densities were identical in spite ofa huge memory window exceeding 100 V. Our results indicate that the two physical phenomena, two-terminal quantum Hall conductance and charge-trap memory operation, can be integrated into one device without affecting each other.

  20. Quantum Hall conductance of graphene combined with charge-trap memory operation

    NASA Astrophysics Data System (ADS)

    Kang, Haeyong; Yun, Yoojoo; Park, Jeongmin; Kim, Joonggyu; Kieu Truong, Thuy; Kim, Jeong-Gyun; Park, Nahee; Yun, Hoyeol; Lee, Sang Wook; Lee, Young Hee; Suh, Dongseok

    2015-08-01

    The combination of quantum Hall conductance and charge-trap memory operation was qualitatively examined using a graphene field-effect transistor. The characteristics of two-terminal quantum Hall conductance appeared clearly on the background of a huge conductance hysteresis during a gate-voltage sweep for a device using monolayer graphene as a channel, hexagonal boron-nitride flakes as a tunneling dielectric and defective silicon oxide as the charge storage node. Even though there was a giant shift of the charge neutrality point, the deviation of quantized resistance value at the state of filling factor 2 was less than 1.6% from half of the von Klitzing constant. At high Landau level indices, the behaviors of quantum conductance oscillation between the increasing and the decreasing electron densities were identical in spite of a huge memory window exceeding 100 V. Our results indicate that the two physical phenomena, two-terminal quantum Hall conductance and charge-trap memory operation, can be integrated into one device without affecting each other.

  1. Production of wheat gluten hydrolysates with reduced antigenicity employing enzymatic hydrolysis combined with downstream unit operations.

    PubMed

    Merz, Michael; Kettner, Lucas; Langolf, Emma; Appel, Daniel; Blank, Imre; Stressler, Timo; Fischer, Lutz

    2016-08-01

    Due to allergies or other health disorders a certain segment of the population is not able to safely consume some plant proteins, which are the main protein support in human nutrition. Coeliac disease is a prominent autoimmune disorder and requires a strict adherence to a gluten-free diet. The aim of this study was to identify suitable combinations of enzymatic hydrolysis and common unit operations in food processing (centrifugation, ultra-filtration) to produce gluten-free wheat gluten hydrolysates for food application. To analyse the hydrolysates, a simple and cheap competitive ELISA protocol was designed and validated in this study as well. The competitive ELISA was validated using gliadin spiked skim milk protein hydrolysates, due to the latter application of the assay. The limit of quantification was 4.19 mg kg(-1) , which allowed the identification of gluten-free (<20 mg kg(-1) ) hydrolysates. Enzymatic hydrolysis, including the type of peptidase, and the downstream processing greatly affected the antigenicity of the hydrolysates. Enzymatic hydrolysis and downstream processing operations, such as centrifugation and ultra-filtration, reduced the antigenicity of wheat gluten hydrolysates. Gluten-free hydrolysates were obtained with Flavourzyme after centrifugation (25 g L(-1) substrate) and after 1 kDa ultra-filtration (100 g L(-1) substrate). A multiple peptidase complex, such as Flavourzyme, seems to be required for the production of gluten-free hydrolysates. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  2. Reference-based combined deterministic stochastic subspace identification for experimental and operational modal analysis

    NASA Astrophysics Data System (ADS)

    Reynders, Edwin; Roeck, Guido De

    2008-04-01

    The modal analysis of mechanical or civil engineering structures consists of three steps: data collection, system identification and modal parameter estimation. The system identification step plays a crucial role in the quality of the modal parameters, that are derived from the identified system model, as well as in the number of modal parameters that can be determined. This explains the increasing interest in sophisticated system identification methods for both experimental and operational modal analysis. In purely operational or output-only modal analysis, absolute scaling of the obtained mode shapes is not possible and the frequency content of the ambient forces could be narrow banded so that only a limited number of modes are obtained. This drives the demand for system identification methods that take both artificial and ambient excitation into account so that the amplitude of the artificial excitation can be small compared to that of the ambient excitation. An accurate, robust and efficient system identification method that meets this requirements is combined deterministic-stochastic subspace identification. It can be used both for experimental modal analysis and for operational modal analysis with deterministic inputs. In this paper, the method is generalized to a reference-based version which is faster and, if the chosen reference outputs have the highest SNR values, more accurate than the classical algorithm. The algorithm is validated with experimental data from the Z24 bridge that overpassing the A1 highway between Bern and Zurich in Switzerland, that have been proposed as a benchmark for the assessment of system identification methods for the modal analysis of large structures. With the presented algorithm, the most complete set of modes reported so far is obtained.

  3. HYBRID ALARM SYSTEMS: COMBINING SPATIAL ALARMS AND ALARM LISTS FOR OPTIMIZED CONTROL ROOM OPERATION

    SciTech Connect

    Ronald L. Boring; J.J. Persensky

    2012-07-01

    The US Department of Energy (DOE) is sponsoring research, development, and deployment on Light Water Reactor Sustainability (LWRS), in which the Idaho National Laboratory (INL) is working closely with nuclear utilities to develop technologies and solutions to help ensure the safe operational life extension of current nuclear power plants. One of the main areas of focus is control room modernization. Within control room modernization, alarm system upgrades present opportunities to meet the broader goals of the LWRS project in demonstrating the use and safety of the advanced instrumentation and control (I&C) technologies and the short-term and longer term objectives of the plant. In this paper, we review approaches for and human factors issues behind upgrading alarms in the main control room of nuclear power plants.

  4. Combination of conspicuity improved synthetic mammograms and digital breast tomosynthesis: a promising approach for mass detection

    NASA Astrophysics Data System (ADS)

    Kim, Seong Tae; Kim, Dae Hoe; Ro, Yong Man

    2015-03-01

    In this study, a novel mass detection framework that utilizes the information from synthetic mammograms has been developed for detecting masses in digital breast tomosynthesis (DBT). In clinical study, it is demonstrated that the combination of DBT and full field digital mammography (FFDM) increases the reader performance. To reduce the radiation dose in this approach, synthetic mammogram has been developed in previous researches and it is demonstrated that synthetic mammogram can alternate the FFDM when it is used with DBT. In this study, we investigate the feasibility of the combined approach of DBT and synthetic mammogram in point of computer-aided detection (CAD). As a synthetic mammogram, two-dimensional image was generated by adopting conspicuous voxels of three-dimensional DBT volume in our study. The mass likelihood scores estimated for each mass candidates in synthetic mammogram and DBT are merged to differentiate masses and false positives (FPs) in combined approach. We compared the performance of detecting masses in the proposed combined approach and DBT alone. A clinical data set of 196 DBT volumes was used to evaluate the different detection schemes. The combined approach achieved sensitivity of 80% and 89% with 1.16 and 2.37 FPs per DBT volume. The DBT alone approach achieved same sensitivities with 1.61 and 3.46 FPs per DBT volume. Experimental results show that statistically significant improvement (p = 0.002) is achieved in combined approach compared to DBT alone. These results imply that the information fusion of synthetic mammogram and DBT is a promising approach to detect masses in DBT.

  5. Combined videothoracoscopic and videomediastinoscopic approach improves radicality of minimally invasive mediastinal lymphadenectomy for early stage lung carcinoma.

    PubMed

    Witte, Biruta; Messerschmidt, Antje; Hillebrand, Hubertus; Gross, Stefan; Wolf, Michael; Kriegel, Elke; Neumeister, Wolfgang; Hürtgen, Martin

    2009-02-01

    To assess the feasibility and radicality of a combined thoracoscopic and mediastinoscopic approach to mediastinal lymphadenectomy compared to thoracoscopy only for minimally invasive management of early stage lung carcinoma. Prospective observational study of patients undergoing anatomical thoracoscopic lung resection for lung carcinoma in our department in 2007. Mediastinal lymphadenectomy was performed either thoracoscopically (VATS group) or by a combination of video-assisted mediastinoscopic lymphadenectomy (VAMLA) and thoracoscopy (VAMLA+VATS group). Inclusion criteria for the study were: stage Ia on CT scan, no central tumor at bronchoscopy, and no contraindications against lobectomy or segmentectomy. Eighteen VAMLA+VATS and fourteen VATS patients were studied. For histology, pTNM stage, type of resection, semiquantitative assessment of the fissure and vascular dissection plane, conversions, blood loss, operation time, adverse events and drainage time, no differences between the two groups were observed. In the VATS group, there was a slight preponderance of women, and right-sided tumors. In the VAMLA+VATS group, both the number of dissected mediastinal lymph node stations (mean, 6.4 stations vs 3.6 stations) and the weight of the mediastinal specimen (median, 11.2 groups vs 5.5 groups), were significantly higher than in the VATS group (p<0.05). A combined approach by VATS and VAMLA improves radicality of minimally invasive mediastinal lymphadenectomy without increase in operation time, morbidity, and drainage time.

  6. A combined surface and bulk TCAD damage model for the analysis of radiation detectors operating at HL-LHC fluences

    NASA Astrophysics Data System (ADS)

    Morozzi, A.; Passeri, D.; Moscatelli, F.; Dalla Betta, G.-F.; Bilei, G. M.

    2016-12-01

    In this work we present the development and the application of a new TCAD modelling scheme to simulate the effects of radiation damage on silicon radiation detectors at the very high fluence levels expected at High Luminosity LHC (up to 2 × 1016 1MeV n/cm2). In particular, we propose a combined approach for the analysis of the surface effects (oxide charge build-up and interface trap states introduction) as well as bulk effects (deep level traps and/or recombination centers introduction). Experimental measurements have been carried out aiming at: i) extraction from simple test structures of relevant parameters to be included within the TCAD model and ii) validation of the new modelling scheme through comparison with measurements of different test structures (e.g. different technologies) before and after irradiation. The good agreements between experimental measurements and simulation findings foster the suitability of the TCAD modelling approach as a predictive tool for investigating the radiation detector behavior at different fluences and operating conditions. This would allow the design and optimization of innovative 3D and planar silicon detectors for future HL-LHC High Energy Physics experiments.

  7. Operative Treatment of Terrible Triad of the Elbow via Posterolateral and Anteromedial Approaches.

    PubMed

    Chen, Hong-Wei; Liu, Guo-dong; Ou, Shan; Fei, Jun; Zhao, Gang-sheng; Wu, Li-Jun; Pan, Jun

    2015-01-01

    The aim of the study was to explore the clinical outcome of posterolateral and anteromedial approaches in treatment of terrible triad of the elbow. The study involved 12 patients with closed terrible triad of the elbow treated by posterolateral and anteromedial approaches between January 2010 and June 2012. The mechanism of injury included fall from height in 9 patients and traffic accident in 3. According to O'Driscoll classification for fractures of the ulnar coronoid, there were 11 patients with type Ⅰ and 1 with type Ⅱ fractures. According to Mason classification for fractures of the radial head, there were 3 patients with type Ⅰ, 7 with type Ⅱ and 2 with type Ⅲ fractures. All patients were followed up for 12-27 months (average 15.5 months), which showed no pain or severe pain in all patients except for 2 patients with mild pain. At the last follow-up, the mean flexion was for 125°(range, 90°-140°), the mean extension loss for 20°(range, 0°-70°), the mean pronation for 66°(range, 20°-85°) and the mean supination for 60°(range, 30°-85°). The bony union time was 8-14 weeks (average 11 weeks) and the elbows were stable in flexion-extension and varus-valgus in all patients. The elbows maintained a concentric reduction of both the ulnotrochlear and the radiocapitellar articulation. Mild heterotopic ossification of the elbow occurred in 3 patients at 6 months after operation and mild degenerative change in 1 patient at 18 months after operation. The Broberg and Morrey elbow performance score was 82 points (range, 58-98 points). The results were excellent in 6 patients, good in 4, fair in 1 and poor in 1, with excellence rate of 83.3%. The results showed that the combined posterolateral and anteromedial approaches can facilitate the reduction and fixation of terrible triad of the elbow. Repair of radial head, coronoid, medial and lateral collateral ligaments can sufficiently restore the elbow stability, allow early postoperative motion and

  8. 10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... nuclear power reactor included in a single referenced safety analysis report means the design of those... Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple...

  9. 10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... nuclear power reactor included in a single referenced safety analysis report means the design of those... Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple...

  10. 10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... nuclear power reactor included in a single referenced safety analysis report means the design of those... Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple...

  11. OPERATIONAL EXPERIENCE: UPGRADED MPC AND A SYSTEMS FOR THE RADIOCHEMICAL PLANT OF THE SIBERIAN CHEMICAL COMBINE

    SciTech Connect

    RODRIGUEZ,C.GOLOSKOKOV,I.FISHBONE,L.GOODEY,K.LOOMIS,M.CRAIN,B.JR.LARSEN,R.

    2003-07-18

    The success of reducing the risk of nuclear proliferation through physical protection and material control/accounting systems depends upon the development of an effective design that includes consideration of the objectives of the systems and the resources available to implement the design. Included among the objectives of the design are facility characterization, definition of threat, and identification of targets. When considering resources, the designer must consider funds available, rapid low-cost elements, technology elements, human resources, and the availability of resources to sustain operation of the end system. The Siberian Chemical Combine (SCC) is a multi-function nuclear facility located in the Tomsk region of Siberia, Russia. Beginning in 1996, SCC joined with the United States Department of Energy (US/DOE) Material Protection, Control, and Accounting (MPC&A) Program to develop and implement MPC&A upgrades for the Radiochemical, Chemical Metallurgical, Conversion, Uranium Enrichment, and Reactor Plants of the SCC. At the Radiochemical Plant the MPC&A design and implementation process has been largely completed for the Plutonium Storage Facility and related areas of the Radiochemical Plant. Design and implementation of upgrades for the Radiochemical Plant include rapid physical protection upgrades such as bricking up of doors and windows, and installation of security-hardened doors. Rapid material control and accounting upgrades include installation of modern balances and bar code equipment. Comprehensive MPC&A upgrades include the installation of access controls to sensitive areas of the Plant, alarm communication and display (AC&D) systems to detect and annunciate alarm conditions, closed circuit (CCTV) systems to assess alarm conditions, central and secondary alarm station upgrades that enable security forces to assess and respond to alarm conditions, material control and accounting upgrades that include upgraded physical inventory procedures, and

  12. Effects of tramadol, morphine or their combination in dogs undergoing ovariohysterectomy on peri-operative electroencephalographic responses and post-operative pain.

    PubMed

    Kongara, K; Chambers, J P; Johnson, C B

    2012-03-01

    To compare the peri-operative electroencephalogram (EEG) responses and post-operative analgesic efficacy of pre-operative morphine or tramadol with a combination of low-dose pre-operative morphine and post-operative tramadol, in dogs undergoing ovariohysterectomy. Dogs undergoing routine ovariohysterectomy were treated with either pre-operative morphine (0.5 mg/kg S/C, n=8), or tramadol (3 mg/kg S/C, n=8), or pre-operative low-dose morphine (0.1 mg/kg S/C) and post-operative tramadol (3 mg/kg I/V, n=8). All dogs received routine pre-anaesthetic medication, and anaesthesia was induced with I/V thiopentone to effect and maintained with halothane in oxygen. Respiratory rate, heart rate, end-tidal halothane tension (EtHal) and end-tidal CO₂ tension (EtCO₂) were monitored throughout surgery. The EEG was recorded continuously in a three electrode montage. Median frequency (F50), total power (Ptot) and 95% spectral edge frequency (F95) of the EEG power spectra were compared during different 100-second periods of surgery: prior to and during skin incision, ligation of each ovarian pedicle, ligation of uterine body and skin closure. Post-operatively, pain was assessed using the short form of the Glasgow composite measure pain scale (CMPS-SF). There was no difference in F50 or Ptot of the EEG between baseline and noxious surgical events within each treatment group, or between the three groups (p>0.05). The mean F95 was higher during the first three periods of surgery for dogs administered tramadol and low-dose morphine than those that received 0.5 mg/kg morphine (p=0.001). Dogs that received low-dose morphine and tramadol had lower CMPS-SF pain scores after ovariohysterectomy than those that received either tramadol or morphine alone (p=0.001). There was no difference in pain scores between dogs in the latter two groups. Tramadol and morphine administered pre-operatively provided an equal degree of post-operative analgesia in dogs after ovariohysterectomy. A combination

  13. [COMBINED POSTERIOR AND ANTERIOR APPROACHES FOR RESECTION OF THORACOLUMBAR SPINAL HUGE DUMBBELL-SHAPED TUMOR].

    PubMed

    Shi, Jiandang; Zhao, Chen; Ding, Huiqiang; Fu, Bin; Niu, Ningkui; Yue, Xuefeng; Yang, Zongqiang; He, Yin

    2016-02-01

    To investigate the surgical outcome of combined posterior and anterior approaches for the resection of thoracolumbar spinal canal huge dumbbell-shaped tumor. Between January 2009 and March 2015, 12 patients with thoracolumbar spinal canal huge dumbbell-shaped tumor were treated by posterior approach and anterolateral approach through diaphragmatic crura and thoracoabdominal incision for complete resection. There were 9 males and 3 females, with an average age of 45 years (range, 30-65 years). The disease duration was 8-64 weeks (mean, 12.7 weeks). The tumor was located at T(12), L1 in 6 cases, at L(1,2) in 5 cases, and at L(2,3) in 1 case. The tumor size ranged from 4.3 cm x 4.0 cm x 3.5 cm to 7.5 cm x 6.3 cm x 6.0 cm. According to tumor outside the spinal involvement scope and site and based on the typing of Eden, 5 cases were rated as type b, 2 cases as type d, 4 cases as type e, and 1 case as type f in the transverse direction; two segments were involved in 8 cases, and more than two segments in 4 cases. The degree of tumor excision, tumor recurrence, and the spine stability were observed during follow-up. The verbal rating scale (VRS) was used to evaluate pain improvement. The average surgical time was 170 minutes (range, 150-230 minutes); the average intraoperative blood loss was 350 mL (range, 270-600 mL). All incisions healed by first intention, and no thoracic cavity infection and other operation related complication occurred. Of 12 cases, 10 were histologically confirmed as schwannoma, and 2 as neurofibroma. The patients were followed up 6 months to 6 years (mean, 31 months). Neurological symptoms were significantly improved in all patients, without lower back soreness. The thoracolumbar X-ray film and MRI showed no tumor residue. No tumor recurrence, internal fixator loosening, scoliosis, and other complications were observed during follow-up. VRS at last follow-up was significantly improved to grade 0 (10 cases) or grade 1 (2 cases) from preoperative

  14. On the preventive management of sediment-related sewer blockages: a combined maintenance and routing optimization approach.

    PubMed

    Fontecha, John E; Akhavan-Tabatabaei, Raha; Duque, Daniel; Medaglia, Andrés L; Torres, María N; Rodríguez, Juan Pablo

    In this work we tackle the problem of planning and scheduling preventive maintenance (PM) of sediment-related sewer blockages in a set of geographically distributed sites that are subject to non-deterministic failures. To solve the problem, we extend a combined maintenance and routing (CMR) optimization approach which is a procedure based on two components: (a) first a maintenance model is used to determine the optimal time to perform PM operations for each site and second (b) a mixed integer program-based split procedure is proposed to route a set of crews (e.g., sewer cleaners, vehicles equipped with winches or rods and dump trucks) in order to perform PM operations at a near-optimal minimum expected cost. We applied the proposed CMR optimization approach to two (out of five) operative zones in the city of Bogotá (Colombia), where more than 100 maintenance operations per zone must be scheduled on a weekly basis. Comparing the CMR against the current maintenance plan, we obtained more than 50% of cost savings in 90% of the sites.

  15. Analysis of the Impact of Decreasing District Heating Supply Temperature on Combined Heat and Power Plant Operation

    NASA Astrophysics Data System (ADS)

    Bolonina, Alona; Bolonins, Genadijs; Blumberga, Dagnija

    2014-12-01

    District heating systems are widely used to supply heat to different groups of heat consumers. The district heating system offers great opportunities for combined heat and power production. In this paper decreasing district heating supply temperature is analysed in the context of combined heat and power plant operation. A mathematical model of a CHP plant is developed using both empirical and theoretical equations. The model is used for analysis of modified CHP plant operation modes with reduced district heating supply temperature. Conclusions on the benefits of new operation modes are introduced.

  16. Removal of the submandibular gland using a combined retroauricular and transoral approach.

    PubMed

    Chen, Wei-liang; Yang, Zhao-hui; Wang, Yong-jie; Huang, Zhi-quan; Wang, You-yuan

    2009-03-01

    To evaluate the feasibility and outcome of a combined retroauricular and transoral approach for removing the submandibular gland. Thirteen patients underwent removal of benign submandibular gland lesions (6 sialoadenitis with sialolithiasis, 4 chronic sialoadenitis, and 3 pleomorphic adenomas) using a combined retroauricular and intraoral approach. All 13 submandibular sialoadenectomies were successful and all of the wounds healed uneventfully. A temporary deficit of the lingual nerve developed in 2 cases and mild limited movement of the tongue developed in 3 cases. No patient suffered from weakness of the marginal mandibular branch of the facial nerve. The follow-up averaged 14.1 months (range, 6-24 months); no tumors recurred. The incision scars were invisible. Submandibular gland resection using a combined retroauricular and transoral approach is a feasible method for benign submandibular gland lesions that provides an acceptable cosmetic outcome.

  17. Optimizing water supply and hydropower reservoir operation rule curves: An imperialist competitive algorithm approach

    NASA Astrophysics Data System (ADS)

    Afshar, Abbas; Emami Skardi, Mohammad J.; Masoumi, Fariborz

    2015-09-01

    Efficient reservoir management requires the implementation of generalized optimal operating policies that manage storage volumes and releases while optimizing a single objective or multiple objectives. Reservoir operating rules stipulate the actions that should be taken under the current state of the system. This study develops a set of piecewise linear operating rule curves for water supply and hydropower reservoirs, employing an imperialist competitive algorithm in a parameterization-simulation-optimization approach. The adaptive penalty method is used for constraint handling and proved to work efficiently in the proposed scheme. Its performance is tested deriving an operation rule for the Dez reservoir in Iran. The proposed modelling scheme converged to near-optimal solutions efficiently in the case examples. It was shown that the proposed optimum piecewise linear rule may perform quite well in reservoir operation optimization as the operating period extends from very short to fairly long periods.

  18. PBO Operations in Alaska and Cascadia, Combining Regions and Collaborating with our Regional Partners

    NASA Astrophysics Data System (ADS)

    Austin, K. E.; Boyce, E. S.; Dausz, K.; Feaux, K.; Mattioli, G. S.; Pyatt, C.; Willoughby, H.; Woolace, A. C.

    2015-12-01

    During the last year, the Alaska and the Cascadia regions of the EarthScope Plate Boundary Observatory (PBO) network were combined into a single management unit. While both remain distinct regions with their own challenges and engineering staff, every effort has been made to operate as a single team to improve efficiency and provide the highest possible data quality and uptime. Over the last several years a concerted effort has been made to work collaboratively with other institutions and stakeholders to defray ongoing costs by sharing staff and resources. UNAVCO currently operates four integrated GPS/seismic stations in collaboration with the Alaska Earthquake Center, eight with the Alaska Volcano Observatory, and three with the EarthScope TA. By the end of 2015, PBO and TA plan to install another 3 integrated and/or co-located geodetic and seismic systems. While most of these are designed around existing PBO stations, the 2014 installation at Middleton Island is a new station for both groups, providing PBO with an opportunity to expand geodetic data in Alaska. There were two major joint maintenance efforts in 2015:, the largest was a 5 day mission among PBO, AVO, and TA, which shared boat, helicopter, and staff on and around Augustine Volcano; the second, was a 10 day helicopter mission shared between AVO and PBO on Unimak Island. PBO Pacific Northwest is working closely with University of Washington to co-locate at least 9 Earthquake Early Warning Systems, which include the addition of strong motion sensors and high speed RT telemetry at PBO sites. The project is managed by University of Washington but UNAVCO is providing land contact information and infrastructure support. Summer 2015 upgrades include a complete overhaul of aging radio technology at two major networks and several small radio networks in Cascadia. The upgrades will increase reliability and enhance the speed of existing telemetry infrastructure and will continue through summer 2018.

  19. Image-Based Airborne Sensors: A Combined Approach for Spectral Signatures Classification through Deterministic Simulated Annealing.

    PubMed

    Guijarro, María; Pajares, Gonzalo; Herrera, P Javier

    2009-01-01

    The increasing technology of high-resolution image airborne sensors, including those on board Unmanned Aerial Vehicles, demands automatic solutions for processing, either on-line or off-line, the huge amountds of image data sensed during the flights. The classification of natural spectral signatures in images is one potential application. The actual tendency in classification is oriented towards the combination of simple classifiers. In this paper we propose a combined strategy based on the Deterministic Simulated Annealing (DSA) framework. The simple classifiers used are the well tested supervised parametric Bayesian estimator and the Fuzzy Clustering. The DSA is an optimization approach, which minimizes an energy function. The main contribution of DSA is its ability to avoid local minima during the optimization process thanks to the annealing scheme. It outperforms simple classifiers used for the combination and some combined strategies, including a scheme based on the fuzzy cognitive maps and an optimization approach based on the Hopfield neural network paradigm.

  20. Enhanced vulnerability assessment in karst areas by combining mapping with modeling approaches.

    PubMed

    Butscher, Christoph; Huggenberger, Peter

    2009-01-15

    The objective of this work is to facilitate a sustainable regional planning of water resources in karst areas by providing a conceptual framework for an integrative vulnerability assessment. A combined mapping and modeling approach is proposed, taking into account both spatial and temporal aspects of karst groundwater vulnerability. The conceptual framework comprises the delineation of recharge areas, vulnerability mapping, numerical flow and transport modeling and the integration of information into a combined vulnerability map and time series. The approach is illustrated at a field site in northwest Switzerland (Gempen plateau). The results show that the combination of vulnerability mapping and numerical modeling allows the vulnerability distribution, both in the recharge and discharge areas, to be identified, and at the same time, the time dependence of karst groundwater vulnerability to be assessed. The combined vulnerability map and time series provide a quantitative basis for drinking water management and for regional planning.

  1. Image-Based Airborne Sensors: A Combined Approach for Spectral Signatures Classification through Deterministic Simulated Annealing

    PubMed Central

    Guijarro, María; Pajares, Gonzalo; Herrera, P. Javier

    2009-01-01

    The increasing technology of high-resolution image airborne sensors, including those on board Unmanned Aerial Vehicles, demands automatic solutions for processing, either on-line or off-line, the huge amountds of image data sensed during the flights. The classification of natural spectral signatures in images is one potential application. The actual tendency in classification is oriented towards the combination of simple classifiers. In this paper we propose a combined strategy based on the Deterministic Simulated Annealing (DSA) framework. The simple classifiers used are the well tested supervised parametric Bayesian estimator and the Fuzzy Clustering. The DSA is an optimization approach, which minimizes an energy function. The main contribution of DSA is its ability to avoid local minima during the optimization process thanks to the annealing scheme. It outperforms simple classifiers used for the combination and some combined strategies, including a scheme based on the fuzzy cognitive maps and an optimization approach based on the Hopfield neural network paradigm. PMID:22399989

  2. Operational earthquake forecasting in California: A prototype system combining UCERF3 and CyberShake

    NASA Astrophysics Data System (ADS)

    Milner, K. R.; Jordan, T. H.; Field, E. H.

    2014-12-01

    Operational earthquake forecasting (OEF) is the dissemination of authoritative information about time-dependent earthquake probabilities to help communities prepare for potentially destructive earthquakes. The goal of OEF is to inform the decisions that people and organizations must continually make to mitigate seismic risk and prepare for potentially destructive earthquakes on time scales from days to decades. To attain this goal, OEF must provide a complete description of the seismic hazard—ground motion exceedance probabilities as well as short-term rupture probabilities—in concert with the long-term forecasts of probabilistic seismic hazard analysis. We have combined the Third Uniform California Earthquake Rupture Forecast (UCERF3) of the Working Group on California Earthquake Probabilities (Field et al., 2014) with the CyberShake ground-motion model of the Southern California Earthquake Center (Graves et al., 2011; Callaghan et al., this meeting) into a prototype OEF system for generating time-dependent hazard maps. UCERF3 represents future earthquake activity in terms of fault-rupture probabilities, incorporating both Reid-type renewal models and Omori-type clustering models. The current CyberShake model comprises approximately 415,000 earthquake rupture variations to represent the conditional probability of future shaking at 285 geographic sites in the Los Angeles region (~236 million horizontal-component seismograms). This combination provides significant probability gains relative to OEF models based on empirical ground-motion prediction equations (GMPEs), primarily because the physics-based CyberShake simulations account for the rupture directivity, basin effects, and directivity-basin coupling that are not represented by the GMPEs.

  3. Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures

    PubMed Central

    Goldman, Alberto; Wollina, Uwe

    2010-01-01

    Facial rejuvenation is a significant process involved in restoring youthfulness. The introduction of less invasive procedures has increased acceptance of such procedures. Often a combination of different techniques allows individualized treatment with optimal outcomes. Furthermore, this leads to a natural look without a significant downtime. We report herein the use of such a combined approach in middle-aged women with particular emphasis on botulinum toxin type A, dermal fillers, and chemical peels. PMID:20924438

  4. A Hybrid Approach to Composite Damage and Failure Analysis Combining Synergistic Damage Mechanics and Peridynamics

    DTIC Science & Technology

    2016-06-30

    composites . However, this temperature can be varied. Today, resins are avai lable to do room temperature curing of thermosetting resins . Therefore, the... Composite Damage and Failure Analysis Combining Synerg istic Damage Mechanics and Peridynamics Sb. GRANT NUMBER N00014-16-1 -2 173 Sc. PROGRAM ELEMENT...by ANSI Std. Z39.18 Quarterly Progress Report, Aprill -June 30, 2016 A Hybrid Approach to Composite Damage and Failure Analysis Combining

  5. A deterministic-stochastic approach to compute the Boltzmann collision integral in O(MN) operations

    NASA Astrophysics Data System (ADS)

    Alekseenko, Alexander; Nguyen, Truong; Wood, Aihua

    2016-11-01

    We developed and implemented a numerical algorithm for evaluating the Boltzmann collision operator with O(MN) operations, where N is the number of the discrete velocity points and M < N. The approach is formulated using a bilinear convolution form of the Galerkin projection of the collision operator and discontinuous Galerkin (DG) discretizations of the collision operator. Key ingredients of the new approach are singular value decomposition (SVD) compression of the collision kernel and approximations of the solution by a sum of Maxwellian streams using a stochastic likelihood maximization algorithm. The developed method is significantly faster than the full deterministic DG velocity discretization of the collision integral. Accuracy of the method is established on solutions to the problem of spatially homogeneous relaxation.

  6. An approach to combining heuristic and qualitative reasoning in an expert system

    NASA Technical Reports Server (NTRS)

    Jiang, Wei-Si; Han, Chia Yung; Tsai, Lian Cheng; Wee, William G.

    1988-01-01

    An approach to combining the heuristic reasoning from shallow knowledge and the qualitative reasoning from deep knowledge is described. The shallow knowledge is represented in production rules and under the direct control of the inference engine. The deep knowledge is represented in frames, which may be put in a relational DataBase Management System. This approach takes advantage of both reasoning schemes and results in improved efficiency as well as expanded problem solving ability.

  7. An approach to combining heuristic and qualitative reasoning in an expert system

    NASA Technical Reports Server (NTRS)

    Jiang, Wei-Si; Han, Chia Yung; Tsai, Lian Cheng; Wee, William G.

    1988-01-01

    An approach to combining the heuristic reasoning from shallow knowledge and the qualitative reasoning from deep knowledge is described. The shallow knowledge is represented in production rules and under the direct control of the inference engine. The deep knowledge is represented in frames, which may be put in a relational DataBase Management System. This approach takes advantage of both reasoning schemes and results in improved efficiency as well as expanded problem solving ability.

  8. Dual-mode Operation of a Rocket-Ramjet Combined Cycle Engine

    NASA Astrophysics Data System (ADS)

    Tomioka, Sadatake; Tani, Koichiro; Masumoto, Ryo; Ueda, Shuuichi

    One-dimensional evaluation of Ramjet-mode operation was carried out on a rocket-ramjet combined cycle engine model. For simplicity, instantaneous mixing between the airflow and rocket exhaust, instantaneous heat release, and pressure recovery by a normal-shock wave were assumed. Shock wave location was so decided that the heat release at the injection (heat addition) location was to thermally-choke the combustion gas flow. By changing the injection location, it was shown that a further downstream injection resulted in a further thrust production and a further fuel flow rate requirement for choking, and a lesser specific impulse. Balancing the thrust production and the specific impulse in terms of the launch vehicle acceleration performance should be pursued. The total pressure loss within the engine model was dominated by the shock wave location, not depended on injection location and fuel flow rate, so that having shock wave penetration to further upstream location was beneficial both for thrust production in the engine and at the external nozzle.

  9. Combined analysis of job and task benzene air exposures among workers at four US refinery operations

    PubMed Central

    Shin, Jennifer (Mi); Unice, Ken M; Gaffney, Shannon H; Kreider, Marisa L; Gelatt, Richard H; Panko, Julie M

    2016-01-01

    Workplace air samples analyzed for benzene at four US refineries from 1976 to 2007 were pooled into a single dataset to characterize similarities and differences between job titles, tasks and refineries, and to provide a robust dataset for exposure reconstruction. Approximately 12,000 non-task (>180 min) personal samples associated with 50 job titles and 4000 task (<180 min) samples characterizing 24 tasks were evaluated. Personal air sample data from four individual refineries were pooled based on a number of factors including (1) the consistent sampling approach used by refinery industrial hygienists over time, (2) the use of similar exposure controls, (3) the comparability of benzene content of process streams and end products, (4) the ability to assign uniform job titles and task codes across all four refineries, and (5) our analysis of variance (ANOVA) of the distribution of benzene air concentrations for select jobs/tasks across all four refineries. The jobs and tasks most frequently sampled included those with highest potential contact with refinery product streams containing benzene, which reflected the targeted sampling approach utilized by the facility industrial hygienists. Task and non-task data were analyzed to identify and account for significant differences within job-area, task-job, and task-area categories. This analysis demonstrated that in general, areas with benzene containing process streams were associated with greater benzene air concentrations compared to areas with process streams containing little to no benzene. For several job titles and tasks analyzed, there was a statistically significant decrease in benzene air concentration after 1990. This study provides a job and task-focused analysis of occupational exposure to benzene during refinery operations, and it should be useful for reconstructing refinery workers’ exposures to benzene over the past 30 years. PMID:26862134

  10. Combined analysis of job and task benzene air exposures among workers at four US refinery operations.

    PubMed

    Burns, Amanda; Shin, Jennifer Mi; Unice, Ken M; Gaffney, Shannon H; Kreider, Marisa L; Gelatt, Richard H; Panko, Julie M

    2017-03-01

    Workplace air samples analyzed for benzene at four US refineries from 1976 to 2007 were pooled into a single dataset to characterize similarities and differences between job titles, tasks and refineries, and to provide a robust dataset for exposure reconstruction. Approximately 12,000 non-task (>180 min) personal samples associated with 50 job titles and 4000 task (<180 min) samples characterizing 24 tasks were evaluated. Personal air sample data from four individual refineries were pooled based on a number of factors including (1) the consistent sampling approach used by refinery industrial hygienists over time, (2) the use of similar exposure controls, (3) the comparability of benzene content of process streams and end products, (4) the ability to assign uniform job titles and task codes across all four refineries, and (5) our analysis of variance (ANOVA) of the distribution of benzene air concentrations for select jobs/tasks across all four refineries. The jobs and tasks most frequently sampled included those with highest potential contact with refinery product streams containing benzene, which reflected the targeted sampling approach utilized by the facility industrial hygienists. Task and non-task data were analyzed to identify and account for significant differences within job-area, task-job, and task-area categories. This analysis demonstrated that in general, areas with benzene containing process streams were associated with greater benzene air concentrations compared to areas with process streams containing little to no benzene. For several job titles and tasks analyzed, there was a statistically significant decrease in benzene air concentration after 1990. This study provides a job and task-focused analysis of occupational exposure to benzene during refinery operations, and it should be useful for reconstructing refinery workers' exposures to benzene over the past 30 years.

  11. Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery.

    PubMed

    Fang, Ye

    2015-04-01

    Drug discovery is a long and costly process. Innovations and paradigm shifts are essential for continuous improvement in the productivity of pharmaceutical R&D. The author reviews the progress of label-free cell phenotypic and computational approaches in early drug discovery since 2004 and proposes a novel paradigm, which combines both approaches. Label-free cell phenotypic profiling techniques offer an unprecedented and integrated approach to comprehend drug-target interactions in their native environments. However, these approaches have disadvantages associated with the lack of molecular details. Computational approaches, including ligand-, structure- and phenotype-based virtual screens, have become versatile tools in the early drug discovery process. However, these approaches mostly predict the binding of drug molecules to targets of interest and are limited to targets that are either well annotated for ligands or that are structurally resolved. Thus, combining label-free cell phenotypic profiling with computational approaches can provide a potential paradigm to accelerate novel drug discovery by taking advantages of the best of both approaches.

  12. Combining probability from independent tests: the weighted Z-method is superior to Fisher's approach.

    PubMed

    Whitlock, M C

    2005-09-01

    The most commonly used method in evolutionary biology for combining information across multiple tests of the same null hypothesis is Fisher's combined probability test. This note shows that an alternative method called the weighted Z-test has more power and more precision than does Fisher's test. Furthermore, in contrast to some statements in the literature, the weighted Z-method is superior to the unweighted Z-transform approach. The results in this note show that, when combining P-values from multiple tests of the same hypothesis, the weighted Z-method should be preferred.

  13. SimSup's Loop: A Control Theory Approach to Spacecraft Operator Training

    NASA Technical Reports Server (NTRS)

    Owens, Brandon Dewain; Crocker, Alan R.

    2015-01-01

    Immersive simulation is a staple of training for many complex system operators, including astronauts and ground operators of spacecraft. However, while much has been written about simulators, simulation facilities, and operator certification programs, the topic of how one develops simulation scenarios to train a spacecraft operator is relatively understated in the literature. In this paper, an approach is presented for using control theory as the basis for developing the immersive simulation scenarios for a spacecraft operator training program. The operator is effectively modeled as a high level controller of lower level hardware and software control loops that affect a select set of system state variables. Simulation scenarios are derived from a STAMP-based hazard analysis of the operator's high and low level control loops. The immersive simulation aspect of the overall training program is characterized by selecting a set of scenarios that expose the operator to the various inadequate control actions that stem from control flaws and inadequate control executions in the different sections of the typical control loop. Results from the application of this approach to the Lunar Atmosphere and Dust Environment Explorer (LADEE) mission are provided through an analysis of the simulation scenarios used for operator training and the actual anomalies that occurred during the mission. The simulation scenarios and inflight anomalies are mapped to specific control flaws and inadequate control executions in the different sections of the typical control loop to illustrate the characteristics of anomalies arising from the different sections of the typical control loop (and why it is important for operators to have exposure to these characteristics). Additionally, similarities between the simulation scenarios and inflight anomalies are highlighted to make the case that the simulation scenarios prepared the operators for the mission.

  14. Probabilistic approach to derive operational intervention levels for nuclear emergency preparedness.

    PubMed

    Lauritzen, B; Bäverstam, U

    1999-08-01

    A probabilistic approach is presented for the derivation of operational intervention levels as guidelines for intervention in a nuclear emergency. The probabilistic approach differs from the standard, deterministic approach in that the many variables needed for a risk and dose estimate are allowed to fluctuate and sampled, rather than using point estimate of key parameters. The fluctuations have a large effect on the operational intervention levels, leading to optimized levels that depend both on the accident scenario and on the distance from the site of the hypothetical accident. The methodology is illustrated for the case of dose rate operational intervention levels for sheltering. At distances larger than a few kilometers, values of dose rate operational intervention levels are obtained that are considerably higher than values developed through deterministic practices. As demonstrated, calculations of site-specific operational intervention levels can augment the emergency preparedness for nuclear facilities. In principle, the approach can be expanded to yield optimized emergency response planning for any nuclear facility subject to various accident conditions.

  15. An Approach to Realizing Process Control for Underground Mining Operations of Mobile Machines.

    PubMed

    Song, Zhen; Schunnesson, Håkan; Rinne, Mikael; Sturgul, John

    2015-01-01

    The excavation and production in underground mines are complicated processes which consist of many different operations. The process of underground mining is considerably constrained by the geometry and geology of the mine. The various mining operations are normally performed in series at each working face. The delay of a single operation will lead to a domino effect, thus delay the starting time for the next process and the completion time of the entire process. This paper presents a new approach to the process control for underground mining operations, e.g. drilling, bolting, mucking. This approach can estimate the working time and its probability for each operation more efficiently and objectively by improving the existing PERT (Program Evaluation and Review Technique) and CPM (Critical Path Method). If the delay of the critical operation (which is on a critical path) inevitably affects the productivity of mined ore, the approach can rapidly assign mucking machines new jobs to increase this amount at a maximum level by using a new mucking algorithm under external constraints.

  16. An Approach to Realizing Process Control for Underground Mining Operations of Mobile Machines

    PubMed Central

    Song, Zhen; Schunnesson, Håkan; Rinne, Mikael; Sturgul, John

    2015-01-01

    The excavation and production in underground mines are complicated processes which consist of many different operations. The process of underground mining is considerably constrained by the geometry and geology of the mine. The various mining operations are normally performed in series at each working face. The delay of a single operation will lead to a domino effect, thus delay the starting time for the next process and the completion time of the entire process. This paper presents a new approach to the process control for underground mining operations, e.g. drilling, bolting, mucking. This approach can estimate the working time and its probability for each operation more efficiently and objectively by improving the existing PERT (Program Evaluation and Review Technique) and CPM (Critical Path Method). If the delay of the critical operation (which is on a critical path) inevitably affects the productivity of mined ore, the approach can rapidly assign mucking machines new jobs to increase this amount at a maximum level by using a new mucking algorithm under external constraints. PMID:26062092

  17. Optimization of chemical fungicide combinations targeting the maize fungal pathogen, Bipolaris maydis: a systematic quantitative approach.

    PubMed

    Wang, Xiang; Ma, Jia; Li, Xiaowei; Zhao, Xiaodong; Lin, Zongli; Chen, Jie; Shao, Zhifeng

    2015-01-01

    To control the southern corn leaf blight, a severe disease of maize around the world, a combination of fungicides is often more potent than using individual fungicides. However, the number of possible combinations increases exponentially with the increase of the number of fungicides combined and their concentrations. It is thus extremely challenging to identify effective fungicide combinations by trial and error from all possible combinations. In this paper, a systematic approach based on a support vector machine, a machine learning algorithm, is proposed to searching for the optimal combinations using only a limited number of measurements. The constructed model also incorporates information related to the inhibition rate (IR) and the cost of each composing fungicide into the optimization process. With this method, we show that only around 130 measurements on a coarse grid of concentrations out of thousands of possible experiments are sufficient to reconstruct the response model and to obtain the optimal fungicide combinations. Experimental results demonstrate that the optimized combinations can achieve an IR greater than 90%, while the required concentrations and the cost of individual fungicides are dramatically reduced. We anticipate that this method should be equally effective in the search for optimal combinations of multiple compounds in other diseases.

  18. Robust processing of phase dislocations based on combined unwrapping and inpainting approaches.

    PubMed

    Xia, Haiting; Montresor, Silvio; Guo, Rongxin; Li, Junchang; Olchewsky, François; Desse, Jean-Michel; Picart, Pascal

    2017-01-15

    This Letter proposes a robust processing of phase dislocations to recover continuous phase maps. The approach is based on combined unwrapping and inpainting methods. Phase dislocations are determined using an estimator based on the second order phase gradient. The algorithm is validated using a realistic simulation of phase dislocations, and the phase restoration exhibits only weak errors. A comparison with other inpainting algorithms is also provided, demonstrating the suitability of the approach. The approach is applied to experimental data from off-axis digital holographic interferometry. The phase dislocation from phase data from a wake flow at Mach 0.73 are identified and processed. Excellent phase restoration can be appreciated.

  19. Combined phosphorescence-holographic approach for singlet oxygen detection in biological media

    NASA Astrophysics Data System (ADS)

    Semenova, I. V.; Belashov, A. V.; Beltukova, D. M.; Petrov, N. V.; Vasyutinskii, O. S.

    2015-06-01

    The paper presents a novel combined approach aimed to detect and monitor singlet oxygen molecules in biological specimens by means of the simultaneous recording and monitoring of their deactivation dynamics in the two complementary channels: radiative and nonradiative. The approach involves both the direct registration of phosphorescence at the wavelength of about 1270 nm caused by radiative relaxation of excited singlet oxygen molecules and holographic recording of thermal disturbances in the medium produced by their nonradiative relaxation. The data provides a complete set of information on singlet oxygen location and dynamics in the medium. The approach was validated in the case study of photosensitized generation of singlet oxygen in onion cell structures.

  20. Simulation of operational typhoon rainfall nowcasting using radar reflectivity combined with meteorological data

    NASA Astrophysics Data System (ADS)

    Wei, Chih-Chiang

    2014-06-01

    In this study, a practical typhoon effective rainfall nowcasting (TERN) model was developed for use in real-time forecasting. The TERN model was derived from a data-driven adaptive network-based fuzzy inference system (ANFIS). The model inputs include meteorological data and radar reflectivity data. The model simulation process begins with an online typhoon warning issued by the Central Weather Bureau (CWB) of Taiwan. It is then determined whether the typhoon approaches the study area according to the typhoon track predicted by the CWB. When a typhoon hits Taiwan, various data are received from sensor instruments, including the ground precipitation data, typhoon climatological data, and radar reflectivity factor by using Weather Surveillance Radar, 1988, Doppler (WSR-88D) products. The study site was Shihmen Catchment. A maximum of 10 typhoon events from 2000 to 2010 were collected. Regarding the model construction, the input combinations of the ground precipitations and reflectivity factors over the catchment functioned as optimal input variables. To verify the practicability of the ANFIS-based TERN model, Typhoon Krosa, which hit Taiwan in 2007, was simulated. The results demonstrated that the proposed methodology of real-time rainfall forecasts during typhoon warning periods yielded favorable performance levels, reliably predicting results regarding 1 h to 6 h forecasting horizons.

  1. A decomposition approach for the combined master surgical schedule and surgical case assignment problems.

    PubMed

    Agnetis, Alessandro; Coppi, Alberto; Corsini, Matteo; Dellino, Gabriella; Meloni, Carlo; Pranzo, Marco

    2014-03-01

    This research aims at supporting hospital management in making prompt Operating Room (OR) planning decisions, when either unpredicted events occur or alternative scenarios or configurations need to be rapidly evaluated. We design and test a planning tool enabling managers to efficiently analyse several alternatives to the current OR planning and scheduling. To this aim, we propose a decomposition approach. More specifically, we first focus on determining the Master Surgical Schedule (MSS) on a weekly basis, by assigning the different surgical disciplines to the available sessions. Next, we allocate surgeries to each session, focusing on elective patients only. Patients are selected from the waiting lists according to several parameters, including surgery duration, waiting time and priority class of the operations. We performed computational experiments to compare the performance of our decomposition approach with an (exact) integrated approach. The case study selected for our simulations is based on the characteristics of the operating theatre (OT) of a medium-size public Italian hospital. Scalability of the method is tested for different OT sizes. A pilot example is also proposed to highlight the usefulness of our approach for decision support. The proposed decomposition approach finds satisfactory solutions with significant savings in computation time.

  2. Analytical solutions for determining extreme water levels in surge tank of hydropower station under combined operating conditions

    NASA Astrophysics Data System (ADS)

    Wang, Bingbao; Guo, Wencheng; Yang, Jiandong

    2017-06-01

    Combined operating condition usually refers to the control operating condition under which the highest and lowest water levels occur in a surge tank of hydropower station. In this paper, with the basic equations of surge analysis and nonlinear vibrational asymptotic method, analytical expressions of the worst superimposition time of surge waves in an upstream surge tank under four typical combined operating conditions (i.e. load-acceptance-then-rejection, successive load rejection, successive load acceptance and load-rejection-then-acceptance) are derived firstly. Then using these expressions, the analytical extreme water levels are determined. The analytical solutions are verified with numerical simulation results. Finally, the effect of the hydraulic resistance coefficient of surge tank on the control operating condition is investigated. The results indicate that: The analytical solutions for determining extreme water levels in surge tank under various combined operating conditions are accurate due to the good agreements between the analytical results and the numerical results. With the increase of the hydraulic resistance coefficient of surge tank, the control operating condition for the highest water level shifts from load-acceptance-then-rejection condition to successive load rejection condition, and the control operating condition for the lowest water level shifts from load-rejection-then-acceptance condition to successive load acceptance condition.

  3. Combination HIV Prevention Interventions: The Potential of Integrated Behavioral and Biomedical Approaches

    PubMed Central

    Brown, Jennifer L.; Sales, Jessica M.; DiClemente, Ralph J.

    2014-01-01

    Background Combination HIV prevention interventions that integrate efficacious behavioral and biomedical strategies offer the potential to reduce new HIV infections. Purpose We overview the efficacy data for three biomedical HIV prevention approaches: microbicides, pre-exposure prophylaxis (PrEP), and an HIV vaccination, review factors associated with differential acceptability and uptake of these methods, and suggest strategies to optimize the effectiveness and dissemination of combination HIV prevention approaches. Methods A narrative review was conducted highlighting key efficacy data for microbicides, PrEP, and an HIV vaccination and summarizing acceptability data for each of the three biomedical HIV prevention approaches. Recommendations for the integration and dissemination of combined behavioral and biomedical HIV prevention approaches are provided. Results To date, microbicides and an HIV vaccination have demonstrated limited efficacy for the prevention of HIV. However, PrEP has demonstrated efficacy in reducing HIV incident infections. A diverse array of factors influences both hypothetical willingness and actual usage of each biomedical prevention method. Conclusions Strategies to effectively integrate and evaluate combination HIV prevention interventions are urgently needed. PMID:25216985

  4. Is Combining Child Labour and School Education the Right Approach? Investigating the Cambodian Case

    ERIC Educational Resources Information Center

    Kim, Chae-Young

    2009-01-01

    The paper considers whether letting children combine work and school is a valid and effective approach in Cambodia. Policy makers' suggestions that child labour should be allowed to some extent due to household poverty appear ungrounded as no significant relation between children's work and household poverty is found while arranging school…

  5. Evaluation of a Combined Treatment Approach for Childhood Apraxia of Speech

    ERIC Educational Resources Information Center

    Iuzzini, Jenya; Forrest, Karen

    2010-01-01

    The current study investigated the impact of a dual treatment approach that included stimulability training protocol (STP) paired with a modified core vocabulary treatment (mCVT) on the speech sounds produced by children with CAS. The combined treatment was assessed for changes in consistency and expansion of the phonetic inventories of four…

  6. Evaluation of the Combined AERCOARE/AERMOD Modeling Approach for Offshore Sources

    EPA Science Inventory

    ENVIRON conducted an evaluation of the combined AERCOARE/AERMOD (AERCOARE-MOD) modeling approach for offshore sources using tracer data from four field studies. AERCOARE processes overwater meteorological data for use by the AERMOD air quality dispersion model (EPA, 2004a). AERC...

  7. Evaluation of a Combined Treatment Approach for Childhood Apraxia of Speech

    ERIC Educational Resources Information Center

    Iuzzini, Jenya; Forrest, Karen

    2010-01-01

    The current study investigated the impact of a dual treatment approach that included stimulability training protocol (STP) paired with a modified core vocabulary treatment (mCVT) on the speech sounds produced by children with CAS. The combined treatment was assessed for changes in consistency and expansion of the phonetic inventories of four…

  8. Assessment of Dysarthric Speech: A Case for a Combined Perceptual and Physiological Approach.

    ERIC Educational Resources Information Center

    Theodoros, Deborah; Murdoch, Bruce; Horton, Sue

    1999-01-01

    Highlights the importance of a combined approach to the assessment of dysarthria with reference to two case studies of individuals with dysarthric speech: a 32-year-old adult who suffered a severe closed head injury and a 9-year-old child who experienced a cerebrovascular accident involving the basilar artery. (Author/VWL)

  9. Assessment of Dysarthric Speech: A Case for a Combined Perceptual and Physiological Approach.

    ERIC Educational Resources Information Center

    Theodoros, Deborah; Murdoch, Bruce; Horton, Sue

    1999-01-01

    Highlights the importance of a combined approach to the assessment of dysarthria with reference to two case studies of individuals with dysarthric speech: a 32-year-old adult who suffered a severe closed head injury and a 9-year-old child who experienced a cerebrovascular accident involving the basilar artery. (Author/VWL)

  10. Combining Best-Practice and Experimental Approaches: Redundancy, Images, and Misperceptions in Multimedia Learning

    ERIC Educational Resources Information Center

    Fenesi, Barbara; Heisz, Jennifer J.; Savage, Philip I.; Shore, David I.; Kim, Joseph A.

    2014-01-01

    This experiment combined controlled experimental design with a best-practice approach (i.e., real course content, subjective evaluations) to clarify the role of verbal redundancy, confirm the multimodal impact of images and narration, and highlight discrepancies between actual and perceived understanding. The authors presented 1 of 3…

  11. Combining Best-Practice and Experimental Approaches: Redundancy, Images, and Misperceptions in Multimedia Learning

    ERIC Educational Resources Information Center

    Fenesi, Barbara; Heisz, Jennifer J.; Savage, Philip I.; Shore, David I.; Kim, Joseph A.

    2014-01-01

    This experiment combined controlled experimental design with a best-practice approach (i.e., real course content, subjective evaluations) to clarify the role of verbal redundancy, confirm the multimodal impact of images and narration, and highlight discrepancies between actual and perceived understanding. The authors presented 1 of 3…

  12. Evaluation of the Combined AERCOARE/AERMOD Modeling Approach for Offshore Sources

    EPA Science Inventory

    ENVIRON conducted an evaluation of the combined AERCOARE/AERMOD (AERCOARE-MOD) modeling approach for offshore sources using tracer data from four field studies. AERCOARE processes overwater meteorological data for use by the AERMOD air quality dispersion model (EPA, 2004a). AERC...

  13. Is Combining Child Labour and School Education the Right Approach? Investigating the Cambodian Case

    ERIC Educational Resources Information Center

    Kim, Chae-Young

    2009-01-01

    The paper considers whether letting children combine work and school is a valid and effective approach in Cambodia. Policy makers' suggestions that child labour should be allowed to some extent due to household poverty appear ungrounded as no significant relation between children's work and household poverty is found while arranging school…

  14. Enhanced Flight Vision Systems and Synthetic Vision Systems for NextGen Approach and Landing Operations

    NASA Technical Reports Server (NTRS)

    Kramer, Lynda J.; Bailey, Randall E.; Ellis, Kyle K. E.; Williams, Steven P.; Arthur, Jarvis J., III; Prinzel, Lawrence J., III; Shelton, Kevin J.

    2013-01-01

    Synthetic Vision Systems and Enhanced Flight Vision System (SVS/EFVS) technologies have the potential to provide additional margins of safety for aircrew performance and enable operational improvements for low visibility operations in the terminal area environment with equivalent efficiency as visual operations. To meet this potential, research is needed for effective technology development and implementation of regulatory standards and design guidance to support introduction and use of SVS/EFVS advanced cockpit vision technologies in Next Generation Air Transportation System (NextGen) operations. A fixed-base pilot-in-the-loop simulation test was conducted at NASA Langley Research Center that evaluated the use of SVS/EFVS in NextGen low visibility approach and landing operations. Twelve crews flew approach and landing operations in a simulated NextGen Chicago O'Hare environment. Various scenarios tested the potential for using EFVS to conduct approach, landing, and roll-out operations in visibility as low as 1000 feet runway visual range (RVR). Also, SVS was tested to evaluate the potential for lowering decision heights (DH) on certain instrument approach procedures below what can be flown today. Expanding the portion of the visual segment in which EFVS can be used in lieu of natural vision from 100 feet above the touchdown zone elevation to touchdown and rollout in visibilities as low as 1000 feet RVR appears to be viable as touchdown performance was acceptable without any apparent workload penalties. A lower DH of 150 feet and/or possibly reduced visibility minima using SVS appears to be viable when implemented on a Head-Up Display, but the landing data suggests further study for head-down implementations.

  15. A multiobjective reinforcement learning approach to water resources systems operation: Pareto frontier approximation in a single run

    NASA Astrophysics Data System (ADS)

    Castelletti, A.; Pianosi, F.; Restelli, M.

    2013-06-01

    The operation of large-scale water resources systems often involves several conflicting and noncommensurable objectives. The full characterization of tradeoffs among them is a necessary step to inform and support decisions in the absence of a unique optimal solution. In this context, the common approach is to consider many single objective problems, resulting from different combinations of the original problem objectives, each one solved using standard optimization methods based on mathematical programming. This scalarization process is computationally very demanding as it requires one optimization run for each trade-off and often results in very sparse and poorly informative representations of the Pareto frontier. More recently, bio-inspired methods have been applied to compute an approximation of the Pareto frontier in one single run. These methods allow to acceptably cover the full extent of the Pareto frontier with a reasonable computational effort. Yet, the quality of the policy obtained might be strongly dependent on the algorithm tuning and preconditioning. In this paper we propose a novel multiobjective Reinforcement Learning algorithm that combines the advantages of the above two approaches and alleviates some of their drawbacks. The proposed algorithm is an extension of fitted Q-iteration (FQI) that enables to learn the operating policies for all the linear combinations of preferences (weights) assigned to the objectives in a single training process. The key idea of multiobjective FQI (MOFQI) is to enlarge the continuous approximation of the value function, that is performed by single objective FQI over the state-decision space, also to the weight space. The approach is demonstrated on a real-world case study concerning the optimal operation of the HoaBinh reservoir on the Da river, Vietnam. MOFQI is compared with the reiterated use of FQI and a multiobjective parameterization-simulation-optimization (MOPSO) approach. Results show that MOFQI provides a

  16. Guide to Combined Heat and Power Systems for Boiler Owners and Operators

    SciTech Connect

    Oland, CB

    2004-08-19

    Combined heat and power (CHP) or cogeneration is the sequential production of two forms of useful energy from a single fuel source. In most CHP applications, chemical energy in fuel is converted to both mechanical and thermal energy. The mechanical energy is generally used to generate electricity, while the thermal energy or heat is used to produce steam, hot water, or hot air. Depending on the application, CHP is referred to by various names including Building Cooling, Heating, and Power (BCHP); Cooling, Heating, and Power for Buildings (CHPB); Combined Cooling, Heating, and Power (CCHP); Integrated Energy Systems (IES), or Distributed Energy Resources (DER). The principal technical advantage of a CHP system is its ability to extract more useful energy from fuel compared to traditional energy systems such as conventional power plants that only generate electricity and industrial boiler systems that only produce steam or hot water for process applications. By using fuel energy for both power and heat production, CHP systems can be very energy efficient and have the potential to produce electricity below the price charged by the local power provider. Another important incentive for applying cogeneration technology is to reduce or eliminate dependency on the electrical grid. For some industrial processes, the consequences of losing power for even a short period of time are unacceptable. The primary objective of the guide is to present information needed to evaluate the viability of cogeneration for new or existing industrial, commercial, and institutional (ICI) boiler installations and to make informed CHP equipment selection decisions. Information presented is meant to help boiler owners and operators understand the potential benefits derived from implementing a CHP project and recognize opportunities for successful application of cogeneration technology. Topics covered in the guide follow: (1) an overview of cogeneration technology with discussions about benefits

  17. Spine deformity surgery in the elderly: risk factors and 30-day outcomes are comparable in posterior versus combined approaches.

    PubMed

    Yue, John K; Sing, David C; Sharma, Sourabh; Upadhyayula, Pavan S; Winkler, Ethan A; Shaw, Jeremy D; Metz, Lionel N

    2017-09-19

    vs. combined approaches to correct deformity in the elderly. Multi-level fusions are associated with increased operation time, HLOS, and discharge to higher level of care.

  18. A Kalman-Filter-Based Approach to Combining Independent Earth-Orientation Series

    NASA Technical Reports Server (NTRS)

    Gross, Richard S.; Eubanks, T. M.; Steppe, J. A.; Freedman, A. P.; Dickey, J. O.; Runge, T. F.

    1998-01-01

    An approach. based upon the use of a Kalman filter. that is currently employed at the Jet Propulsion Laboratory (JPL) for combining independent measurements of the Earth's orientation, is presented. Since changes in the Earth's orientation can be described is a randomly excited stochastic process, the uncertainty in our knowledge of the Earth's orientation grows rapidly in the absence of measurements. The Kalman-filter methodology allows for an objective accounting of this uncertainty growth, thereby facilitating the intercomparison of measurements taken at different epochs (not necessarily uniformly spaced in time) and with different precision. As an example of this approach to combining Earth-orientation series, a description is given of a combination, SPACE95, that has been generated recently at JPL.

  19. Improved Discrimination for Brassica Vegetables Treated with Agricultural Fertilizers Using a Combined Chemometric Approach.

    PubMed

    Yuan, Yuwei; Hu, Guixian; Chen, Tianjin; Zhao, Ming; Zhang, Yongzhi; Li, Yong; Xu, Xiahong; Shao, Shengzhi; Zhu, Jiahong; Wang, Qiang; Rogers, Karyne M

    2016-07-20

    Multielement and stable isotope (δ(13)C, δ(15)N, δ(2)H, δ(18)O, (207)Pb/(206)Pb, and (208)Pb/(206)Pb) analyses were combined to provide a new chemometric approach to improve the discrimination between organic and conventional Brassica vegetable production. Different combinations of organic and conventional fertilizer treatments were used to demonstrate this authentication approach using Brassica chinensis planted in experimental test pots. Stable isotope analyses (δ(15)N and δ(13)C) of B. chinensis using elemental analyzer-isotope ratio mass spectrometry easily distinguished organic and chemical fertilizer treatments. However, for low-level application fertilizer treatments, this dual isotope approach became indistinguishable over time. Using a chemometric approach (combined isotope and elemental approach), organic and chemical fertilizer mixes and low-level applications of synthetic and organic fertilizers were detectable in B. chinensis and their associated soils, improving the detection limit beyond the capacity of individual isotopes or elemental characterization. LDA shows strong promise as an improved method to discriminate genuine organic Brassica vegetables from produce treated with chemical fertilizers and could be used as a robust test for organic produce authentication.

  20. Study of operator's information in the course of complicated and combined activity

    NASA Astrophysics Data System (ADS)

    Krylova, N. V.; Bokovikov, A. K.

    1982-08-01

    Speech characteristics of operators performing control and observation operations, Information reception, transmission and processing, and decision making when exposed to the real stress of parachute jumps were investigated. Form and content speech characteristics whose variations reflect the level of operators adaptation to stressful activities are reported.

  1. Combined orthodontic-surgical approach in the treatment of impacted maxillary canines: three clinical cases

    PubMed Central

    SPUNTARELLI, M.; CECCHETTI, F.; ARCURI, L.; TESTI, D.; MELONE, P.; BIGELLI, E.; GERMANO, F.

    2015-01-01

    SUMMARY Impaction of maxillary canine is a relatively frequent orthodontic anomaly which could represent fuctional and aesthetic problems for patients. Nowadays, the conventional technique to impacted canines consists of a combined orthodontic and surgical approach, aimed to guide cuspids at the center of the alveolar ridge in a stable position and surrounded by healthy hard and soft tissues. This article presents three cases studies with different combined surgical-orthodontic approaches for the treatment of infraosseous impacted canines. An impacted maxillary canine could be guided, after adequate space is created orthodontically, to the center of the ridge through an orthodontic traction directly applied to the crown of impacted cuspid. Several surgical techniques have been proposed to expose the crown of impacted tooth. Location (buccal or palatal side) of impactation and depth influence surgical approach in order to obtain best aesthetic and functional results. PMID:27555906

  2. Resection of huge retrosternal goiter through a novel combined cervical and robot-assisted approach.

    PubMed

    Wang, Shumin; Xu, Shiguang; Liu, Bo

    2014-05-01

    A 53-year-old man was referred to our department with a history of cough, especially at night, for 3 months. He was found to have a huge retrosternal goiter. We applied a novel combined cervical and robot-assisted approach to resect this difficult goiter. Using the da Vinci robot system, the intrathoracic part of the goiter was dissected and mobilized completely from the mediastinum to the inlet of the thorax. The dissected part of the goiter was left in the thorax. A right cervical half-collar incision about 6 cm was then performed. The goiter was finally removed from the neck incision. Histopathologic examination reported a multinodular goiter. By the method shown in the case, resection of huge retrosternal goiters through a combined cervical and robot-assisted approach is feasible and safe. This method provides an alternative option to the more invasive traditional approaches.

  3. IMA clipping for a type ii endoleak: combined laparoscopic and endovascular approach.

    PubMed

    Zhou, Wei; Lumsden, Alan B; Li, James

    2006-08-01

    We describe herein a combined laparoscopic and endovascular approach to treat a type II endoleak due to retrograde flow in the patent inferior mesenteric artery (IMA). A 61-year-old gentleman presented with enlarging aneurysm sac confirmed on computed tomography scan evaluation after elective endovascular repair of an infrarenal abdominal aortic aneurysm. A combined laparoscopic and endovascular approach was used. After distal IMA was identified and marked with a clip laparoscopically, on-table angiography showed a proximal left colic branch and persistent flow in the IMA. Therefore, further laparoscopic exploration was performed by dissection along the distal branch. The origin of IMA was then located and subsequently sealed with 2 surgical clips. The completion angiography confirmed the proper position of the surgical clips and absence of endoleak. Our case demonstrated useful role of endovascular techniques in identifying the origin of IMA during laparoscopic approach for treating type II endoleak.

  4. Boost OCR accuracy using iVector based system combination approach

    NASA Astrophysics Data System (ADS)

    Peng, Xujun; Cao, Huaigu; Natarajan, Prem

    2015-01-01

    Optical character recognition (OCR) is a challenging task because most existing preprocessing approaches are sensitive to writing style, writing material, noises and image resolution. Thus, a single recognition system cannot address all factors of real document images. In this paper, we describe an approach to combine diverse recognition systems by using iVector based features, which is a newly developed method in the field of speaker verification. Prior to system combination, document images are preprocessed and text line images are extracted with different approaches for each system, where iVector is transformed from a high-dimensional supervector of each text line and is used to predict the accuracy of OCR. We merge hypotheses from multiple recognition systems according to the overlap ratio and the predicted OCR score of text line images. We present evaluation results on an Arabic document database where the proposed method is compared against the single best OCR system using word error rate (WER) metric.

  5. Management of cervical fractures in ankylosing spondylitis: anterior, posterior or combined approach?

    PubMed

    Longo, Umile Giuseppe; Loppini, Mattia; Petrillo, Stefano; Berton, Alessandra; Maffulli, Nicola; Denaro, Vincenzo

    2015-09-01

    Ankylosing spondylitis (AS) can lead to an increased risk of cervical fractures. A systematic review was undertaken using the keywords 'ankylosing spondylitis', 'spine fractures', 'cervical fractures', 'surgery' and 'postoperative outcomes' on Medline, Pubmed, Google Scholar, Ovid and Embase, and the quality of the studies included was evaluated according to the Coleman Methodology Score. Surgery ameliorates neurological function in patients with unstable AS-related cervical fractures. The combined anterior/posterior and the posterior approaches are more effective than the anterior approach. The optimal approach, anterior, posterior or combined anterior/posterior, for the management of AS related cervical fractures has not been defined. Open reduction and internal fixation allows avoiding worsening and enhances neurological function in AS patients with cervical fractures. Adequately powered randomized trials with appropriate subjective and objective outcome measures are necessary to reach definitive conclusions. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Vocational Rehabilitation Operations Within a Prison System: One Approach to Serving the Mentally Retarded Public Offender.

    ERIC Educational Resources Information Center

    Phelps, William R.

    The purpose of this paper is to present one approach to providing vocational rehabilitation for the mentally retarded public offender. The rehabilitation process for prison inmates is described, one southeastern state program is reviewed from an operational point of view, and some traits and characteristics of the mentally retarded public offender…

  7. Vocational Rehabilitation Operations Within a Prison System: One Approach to Serving the Mentally Retarded Public Offender.

    ERIC Educational Resources Information Center

    Phelps, William R.

    The purpose of this paper is to present one approach to providing vocational rehabilitation for the mentally retarded public offender. The rehabilitation process for prison inmates is described, one southeastern state program is reviewed from an operational point of view, and some traits and characteristics of the mentally retarded public offender…

  8. Survey Approaches to the Assessment of Family Functioning: Conceptual, Operational, and Analytical Issues.

    ERIC Educational Resources Information Center

    Sabatelli, Ronald M.; Bartle, Suzanne E.

    1995-01-01

    Presents a multidimensional conceptualization of family functioning that is embedded within a family systems framework. Discusses operational issues pertaining to the assessment of family functioning when conceived of as a complex and multidimensional construct, and explores measurement strategies and analytical approaches. (JPS)

  9. Schools' Capacity to Absorb a "Healthy School" Approach into Their Operations: Insights from a Realist Evaluation

    ERIC Educational Resources Information Center

    Deschesnes, Marthe; Drouin, Nathalie; Tessier, Caroline; Couturier, Yves

    2014-01-01

    Purpose: The purpose of this paper is to understand how a Canadian intervention based on a professional development (PD) model did or did not influence schools' capacities to absorb a Healthy School (HS) approach into their operations. This study is the second part of a research project: previously published results regarding this research…

  10. Schools' Capacity to Absorb a "Healthy School" Approach into Their Operations: Insights from a Realist Evaluation

    ERIC Educational Resources Information Center

    Deschesnes, Marthe; Drouin, Nathalie; Tessier, Caroline; Couturier, Yves

    2014-01-01

    Purpose: The purpose of this paper is to understand how a Canadian intervention based on a professional development (PD) model did or did not influence schools' capacities to absorb a Healthy School (HS) approach into their operations. This study is the second part of a research project: previously published results regarding this research…

  11. [Experience of application of multimodal combined spinal-epidural anesthesia during operative interventions for abdominal cavity tumors in children].

    PubMed

    Dmutriiev, D V

    2014-10-01

    The investigations were conducted in 44 children, operated on for abdominal cavity tumors and tumors of ovaries. In patients of the first group a combined spinal-epidural analgesia and a continuous intravenous phentanyl infusion were applied; while in the second group--the intravenous continuous infusion of phentanyl. Conduction of a multimodal analgesia have had reduced significantly a negative outcomes of insufficient analgesia in children and secured an effective analgesia after traumatic operations.

  12. Novel, Web-based, information-exploration approach for improving operating room logistics and system processes.

    PubMed

    Nagy, Paul G; Konewko, Ramon; Warnock, Max; Bernstein, Wendy; Seagull, Jacob; Xiao, Yan; George, Ivan; Park, Adrian

    2008-03-01

    Routine clinical information systems now have the ability to gather large amounts of data that surgical managers can access to create a seamless and proactive approach to streamlining operations and minimizing delays. The challenge lies in aggregating and displaying these data in an easily accessible format that provides useful, timely information on current operations. A Web-based, graphical dashboard is described in this study, which can be used to interpret clinical operational data, allow managers to see trends in data, and help identify inefficiencies that were not apparent with more traditional, paper-based approaches. The dashboard provides a visual decision support tool that assists managers in pinpointing areas for continuous quality improvement. The limitations of paper-based techniques, the development of the automated display system, and key performance indicators in analyzing aggregate delays, time, specialties, and teamwork are reviewed. Strengths, weaknesses, opportunities, and threats associated with implementing such a program in the perioperative environment are summarized.

  13. A non-equilibrium equation-of-motion approach to quantum transport utilizing projection operators.

    PubMed

    Ochoa, Maicol A; Galperin, Michael; Ratner, Mark A

    2014-11-12

    We consider a projection operator approach to the non-equilibrium Green function equation-of-motion (PO-NEGF EOM) method. The technique resolves problems of arbitrariness in truncation of an infinite chain of EOMs and prevents violation of symmetry relations resulting from the truncation (equivalence of left- and right-sided EOMs is shown and symmetry with respect to interchange of Fermi or Bose operators before truncation is preserved). The approach, originally developed by Tserkovnikov (1999 Theor. Math. Phys. 118 85) for equilibrium systems, is reformulated to be applicable to time-dependent non-equilibrium situations. We derive a canonical form of EOMs, thus explicitly demonstrating a proper result for the non-equilibrium atomic limit in junction problems. A simple practical scheme applicable to quantum transport simulations is formulated. We perform numerical simulations within simple models and compare results of the approach to other techniques and (where available) also to exact results.

  14. Robot-assisted Sistrunk operation via a retroauricular approach for thyroglossal duct cyst.

    PubMed

    Kim, Chul-Ho; Byeon, Hyung Kwon; Shin, Yoo Seob; Koh, Yoon Woo; Choi, Eun Chang

    2014-03-01

    Traditionally, simple excisions of midline neck masses were typically performed through an incision on the overlying skin causing displeasing cosmetic outcomes. From the recent demonstrations to overcome these disappointing aesthetic results from overt scars, we propose a novel approach to successfully remove lesions with satisfactory cosmetic outcomes from well-hidden scars. A detailed surgical technique is provided. A 20-year-old female patient with thyroglossal duct cyst (TGDC) was successfully treated via a retroauricular approach utilizing the robotic surgical system. The operative procedure was successfully completed with no conversion to open surgery. The operative time was reasonable and there were no intraoperative complications. Videographic demonstration of the robotic-assisted surgery is included in this study online. Surgical removal of midline neck mass (TGDC) via a retroauricular approach utilizing the robotic surgical system can be a technically feasible and safe treatment option with excellent cosmetic outcomes. Copyright © 2014 Wiley Periodicals, Inc.

  15. An Operational Approach for Selecting Open Source Components in a Software Development Project

    NASA Astrophysics Data System (ADS)

    Majchrowski, Annick; Deprez, Jean-Christophe

    Many organizations have started to integrate Free/Open Source Software (FlOSS) components in their applications. It is therefore crucial for these companies to select the most appropriate FlOSS components in terms of functional and non-functional needs. Although FlOSS selection methods have appeared in the last few years, they lack an operational description. In turn, this has slowed their use in software development project. This work presents an operational approach for selecting FlOSS components where the client, the development team and their respective quality assurance teams are involved in the selection process. Although the case study applying the FlOSS selection approach is left to future work, this article already describes an industrial case where the approach presented in this paper has been approved for use by the various partners, i.e., the client, the development firm and their respective quality teams.

  16. Actual evapotranspiration modeling using the operational Simplified Surface Energy Balance (SSEBop) approach

    USGS Publications Warehouse

    Savoca, Mark E.; Senay, Gabriel B.; Maupin, Molly A.; Kenny, Joan F.; Perry, Charles A.

    2013-01-01

    Remote-sensing technology and surface-energy-balance methods can provide accurate and repeatable estimates of actual evapotranspiration (ETa) when used in combination with local weather datasets over irrigated lands. Estimates of ETa may be used to provide a consistent, accurate, and efficient approach for estimating regional water withdrawals for irrigation and associated consumptive use (CU), especially in arid cropland areas that require supplemental water due to insufficient natural supplies from rainfall, soil moisture, or groundwater. ETa in these areas is considered equivalent to CU, and represents the part of applied irrigation water that is evaporated and/or transpired, and is not available for immediate reuse. A recent U.S. Geological Survey study demonstrated the application of the remote-sensing-based Simplified Surface Energy Balance (SSEB) model to estimate 10-year average ETa at 1-kilometer resolution on national and regional scales, and compared those ETa values to the U.S. Geological Survey’s National Water-Use Information Program’s 1995 county estimates of CU. The operational version of the operational SSEB (SSEBop) method is now used to construct monthly, county-level ETa maps of the conterminous United States for the years 2000, 2005, and 2010. The performance of the SSEBop was evaluated using eddy covariance flux tower datasets compiled from 2005 datasets, and the results showed a strong linear relationship in different land cover types across diverse ecosystems in the conterminous United States (correlation coefficient [r] ranging from 0.75 to 0.95). For example, r for woody savannas (0.75), grassland (0.75), forest (0.82), cropland (0.84), shrub land (0.89), and urban (0.95). A comparison of the remote-sensing SSEBop method for estimating ETa and the Hamon temperature method for estimating potential ET (ETp) also was conducted, using regressions of all available county averages of ETa for 2005 and 2010, and yielded correlations of r = 0

  17. Ethics education for clinician-researchers in genetics: The combined approach.

    PubMed

    Zawati, Ma'n; Cohen, Eliza; Parry, David; Avard, Denise; Syncox, David

    2015-03-01

    Advancements in genomic technology and genetic research have uncovered new and unforeseen ethical and legal issues that must now be faced by clinician-researchers. However, lack of adequate ethical training places clinician-researchers in a position where they might be unable to effectively assess and resolve the issues presented to them. The literature demonstrates that ethics education is relevant and engaging where it is targeted to the level and context of the learners, and it includes real-world based cases approached in innovative ways. In order to test the feasibility of a combined approach to ethics education, a conference was held in 2012 to raise awareness and familiarize participants with the ethical and legal issues surrounding medical technology in genetics and then to have them apply this to reality-based case studies. The conference included participants from a variety of backgrounds and was divided into three sections: (i) informative presentations by experts in the field; (ii) mock REB deliberations; and (iii) a second mock-REB, conducted by a panel of experts. Feedback from participants was positive and indicated that they felt the learning objectives had been met and that the material was presented in a clear and organized fashion. Although only an example of the combined approach in a particular setting, the success of this conference suggests that combining small group learning, practical cases, role-play and interdisciplinary learning provides a positive experience and is an effective approach to ethics education.

  18. Outcomes of a Combined Approach of Percutaneous Coronary Revascularization and Cardiac Valve Surgery.

    PubMed

    Santana, Orlando; Singla, Sandeep; Mihos, Christos G; Pineda, Andrés M; Stone, Gregg W; Kurlansky, Paul A; George, Isaac; Kirtane, Ajay J; Smith, Craig R; Beohar, Nirat

    A subset of patients requiring coronary revascularization and valve surgery may benefit from a combined approach of percutaneous coronary intervention (PCI) and valve surgery, as opposed to the standard median sternotomy approach of combined coronary artery bypass and valve surgery. To evaluate its potential benefits and limitations, a literature search was performed using PubMed, EMBASE, Ovid, and the Cochrane library, through March 2016 to identify all studies involving a combined approach of PCI and valve surgery in patients with coronary artery and valvular disease. There were five studies included in the study with a total of 324 patients, of which 75 (23.1%) had a history of previous cardiac surgery. The interval between PCI and surgery ranged from simultaneous intervention to a median of 38 days (interquartile range, 18-65 days). The surgical approach performed consisted of a minimally invasive one or median sternotomy. There were 275 single valve surgery (84.9%) and 49 double-valve surgery (15.1%) with a 30-day mortality ranging from 0% to 5.5%. The 1-year survival ranged from 78% to 96%, and the follow-up period ranged from 1.3 to 5 years. Herein, we present a review of the literature using this technique.

  19. Environmental impact efficiency of natural gas combined cycle power plants: A combined life cycle assessment and dynamic data envelopment analysis approach.

    PubMed

    Martín-Gamboa, Mario; Iribarren, Diego; Dufour, Javier

    2017-09-26

    The energy sector is still dominated by the use of fossil resources. In particular, natural gas represents the third most consumed resource, being a significant source of electricity in many countries. Since electricity production in natural gas combined cycle (NGCC) plants provides some benefits with respect to other non-renewable technologies, it is often seen as a transitional solution towards a future low‑carbon power generation system. However, given the environmental profile and operational variability of NGCC power plants, their eco-efficiency assessment is required. In this respect, this article uses a novel combined Life Cycle Assessment (LCA) and dynamic Data Envelopment Analysis (DEA) approach in order to estimate -over the period 2010-2015- the environmental impact efficiencies of 20 NGCC power plants located in Spain. A three-step LCA+DEA method is applied, which involves data acquisition, calculation of environmental impacts through LCA, and the novel estimation of environmental impact efficiency (overall- and term-efficiency scores) through dynamic DEA. Although only 1 out of 20 NGCC power plants is found to be environmentally efficient, all plants show a relatively good environmental performance with overall eco-efficiency scores above 60%. Regarding individual periods, 2011 was -on average- the year with the highest environmental impact efficiency (95%), accounting for 5 efficient NGCC plants. In this respect, a link between high number of operating hours and high environmental impact efficiency is observed. Finally, preliminary environmental benchmarks are presented as an additional outcome in order to further support decision-makers in the path towards eco-efficiency in NGCC power plants. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Assessing the impacts of reservoir operation to floodplain inundation by combining hydrological, reservoir management, and hydrodynamic models

    NASA Astrophysics Data System (ADS)

    Mateo, Cherry May; Hanasaki, Naota; Komori, Daisuke; Tanaka, Kenji; Kiguchi, Masashi; Champathong, Adisorn; Sukhapunnaphan, Thada; Yamazaki, Dai; Oki, Taikan

    2014-09-01

    A catastrophic flood event which caused massive economic losses occurred in Thailand, in 2011. Several studies have already been conducted to analyze the Thai floods, but none of them have assessed the impacts of reservoir operation on flood inundation. This study addresses this gap by combining physically based hydrological models to explicitly simulate the impacts of reservoir operation on flooding in the Chao Phraya River Basin, Thailand. H08, an integrated water resources model with a reservoir operation module, was combined with CaMa-Flood, a river routing model with representation of flood dynamics. The combined H08-CaMa model was applied to simulate and assess the historical and alternative reservoir operation rules in the two largest reservoirs in the basin. The combined H08-CaMa model effectively simulated the 2011 flood: regulated flows at a major gauging station have high daily NSE-coefficient of 92% as compared with observed discharge; spatiotemporal extent of simulated flood inundation match well with those of satellite observations. Simulation results show that through the operation of reservoirs in 2011, flood volume was reduced by 8.6 billion m3 and both depth and area of flooding were reduced by 40% on the average. Nonetheless, simple modifications in reservoir operation proved to further reduce the flood volume by 2.4 million m3 and the depth and area of flooding by 20% on the average. By modeling reservoir operation with a hydrodynamic model, a more realistic simulation of the 2011 Thai flood was made possible, and the potential of reducing flood inundation through improved reservoir management was quantified.

  1. Structured Operative Autonomy: An Institutional Approach to Enhancing Surgical Resident Education without Impacting Patient Outcomes.

    PubMed

    Wojcik, Brandon M; Fong, Zhi Ven; Patel, Madhukar S; Chang, David C; Long, Dustin R; Kaafarani, Haytham Ma; Petrusa, Emil; Mullen, John T; Lillemoe, Keith D; Phitayakorn, Roy

    2017-09-04

    Though barriers to granting surgical residents autonomy in the operating room are well described, few have proposed practical strategies to overcome them. Our department adopted a multidisciplinary approach to develop a rotation that aimed to grant chief residents structured operative autonomy. In this study, we assess the feasibility of implementation, impact on patient safety and educational benefit to residents following the program's pilot year. During a one-month rotation, chief residents began cases alone using their own operative block time. The attending surgeon was notified when the critical portion of the operation was reached and supervised its completion. Postoperative complications, intraoperative adverse events (iAEs), readmissions, operation duration, and length of stay in a subset of patients that underwent a cholecystectomy or appendectomy were compared to patients operated on by standard resident services. Follow-up surveys were administered to residents one-year after graduation. 124 operations were performed by chief residents that ranged in complexity. Unadjusted subset analysis comparing the structured operative autonomy (n=54) and standard resident (n=718) services' outcomes for appendectomies and cholecystectomies revealed no significant differences in 30-day postoperative complications (5.6% vs. 4.0%, p=0.59), major iAEs or readmissions (3.7% vs. 3.8%, p=1.00), respectively. Multivariate analysis performed for 30-day complications (OR=0.8, 95% CI=0.2-3.2, p=0.76) and readmissions (OR=0.4, 95% CI=0.1-2.1, p=0.3) corroborated unadjusted findings. All participants (n=8) strongly agreed that the rotation eased their transition to fellowship or independent practice. Structured operative autonomy overcomes known barriers to granting chief residents autonomy in the operating room. When utilized for select general surgery cases, resident education is enhanced without impacting patient outcomes. This training model has the potential to improve the

  2. Global land cover mapping at 30 m resolution: A POK-based operational approach

    NASA Astrophysics Data System (ADS)

    Chen, Jun; Chen, Jin; Liao, Anping; Cao, Xin; Chen, Lijun; Chen, Xuehong; He, Chaoying; Han, Gang; Peng, Shu; Lu, Miao; Zhang, Weiwei; Tong, Xiaohua; Mills, Jon

    2015-05-01

    Global Land Cover (GLC) information is fundamental for environmental change studies, land resource management, sustainable development, and many other societal benefits. Although GLC data exists at spatial resolutions of 300 m and 1000 m, a 30 m resolution mapping approach is now a feasible option for the next generation of GLC products. Since most significant human impacts on the land system can be captured at this scale, a number of researchers are focusing on such products. This paper reports the operational approach used in such a project, which aims to deliver reliable data products. Over 10,000 Landsat-like satellite images are required to cover the entire Earth at 30 m resolution. To derive a GLC map from such a large volume of data necessitates the development of effective, efficient, economic and operational approaches. Automated approaches usually provide higher efficiency and thus more economic solutions, yet existing automated classification has been deemed ineffective because of the low classification accuracy achievable (typically below 65%) at global scale at 30 m resolution. As a result, an approach based on the integration of pixel- and object-based methods with knowledge (POK-based) has been developed. To handle the classification process of 10 land cover types, a split-and-merge strategy was employed, i.e. firstly each class identified in a prioritized sequence and then results are merged together. For the identification of each class, a robust integration of pixel-and object-based classification was developed. To improve the quality of the classification results, a knowledge-based interactive verification procedure was developed with the support of web service technology. The performance of the POK-based approach was tested using eight selected areas with differing landscapes from five different continents. An overall classification accuracy of over 80% was achieved. This indicates that the developed POK-based approach is effective and feasible

  3. 10 CFR Appendix N to Part 52 - Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Standardization of Nuclear Power Plant Designs: Combined Licenses To Construct and Operate Nuclear Power Reactors of Identical Design at Multiple Sites N Appendix N... FOR NUCLEAR POWER PLANTS Pt. 52, App. N Appendix N to Part 52—Standardization of Nuclear Power...

  4. Combined effects of strong and electroweak flavor changing neutral current effective operators in top quark physics at the CERN LHC

    SciTech Connect

    Ferreira, P. M.; Guedes, R. B.; Santos, R.

    2008-06-01

    We study the combined effects of both strong and electroweak dimension six effective operators on flavor changing top quark physics at the CERN LHC. Analytic expressions for the cross sections and decay widths of several flavor changing processes will be presented, as well as an analysis of the feasibility of their observation at the LHC.

  5. 78 FR 67402 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... cases to mail copies on electronic storage media. Participants may not submit paper copies of their...), with their initial paper filing requesting authorization to continue to submit documents in paper... operations, health physics, and quality assurance personnel from operating pressures. This is changed to...

  6. 77 FR 43374 - Biweekly Notice, Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-24

    ... the facility. The proposed changes do not affect any plant operations, design functions, or analyses... proposed change will not result in plant operation in a configuration outside the design bases. The... precursor to any accident or transient. Plant design is not being modified by the proposed change....

  7. Resolving Nuclear Reactor Lifetime Extension Questions: A Combined Multiscale Modeling and Positron Characterization approach

    SciTech Connect

    Wirth, B; Asoka-Kumar, P; Denison, A; Glade, S; Howell, R; Marian, J; Odette, G; Sterne, P

    2004-04-06

    The objective of this work is to determine the chemical composition of nanometer precipitates responsible for irradiation hardening and embrittlement of reactor pressure vessel steels, which threaten to limit the operating lifetime of nuclear power plants worldwide. The scientific approach incorporates computational multiscale modeling of radiation damage and microstructural evolution in Fe-Cu-Ni-Mn alloys, and experimental characterization by positron annihilation spectroscopy and small angle neutron scattering. The modeling and experimental results are

  8. A dual active-restrictive approach to incorporating environmental flow targets into existing reservoir operation rules

    NASA Astrophysics Data System (ADS)

    Shiau, Jenq-Tzong; Wu, Fu-Chun

    2010-08-01

    Environmental flow schemes may be implemented through active or restrictive strategies. The former may be applied via reservoir releases, and the latter can be executed by reducing water demands. We present a dual active-restrictive approach to devising the optimal reservoir operation rules that aim to secure off-stream water supplies while maximizing environmental benefits. For the active part, a multicomponent environmental flow target (including the minimum and monthly flows) is incorporated in the operation rules. For the restrictive counterpart, we use a novel demands partitioning and prioritizing (DPP) approach to reallocating the demands of various sectors. The DPP approach partitions the existing off-stream demand and newly incorporated environmental demand and reassembles the two as the first- and second-priority demands. Water is reallocated to each demand according to the ratios derived from the prioritized demands. The proposed approach is coupled with a multicriteria optimization framework to seek the optimal operation rules for the existing Feitsui Reservoir system (Taiwan) under various scenarios. The best overall performance is achieved by an optimal dual strategy whose operational parameters are all determined by optimization. The optimal environmental flow target may well be a top-priority constant base flow rather than the variable quantities. The active strategy would outperform the restrictive one. For the former, a top-priority base flow target is essential; for the latter, the off-stream demand can become vanishingly small in compensation for the eliminated base flow target, thus promoting the monthly flow target as nearly the top-priority demand. For either the active or restrictive strategy, a prioritized environmental flow demand would provide a path toward the optimal overall performance. A significantly improved overall performance over the existing operation rules is unlikely if the active and restrictive parameters are both favorable

  9. Anatomical basis of transgluteal approach for pudendal neuralgia and operative technique.

    PubMed

    Peltier, Johann

    2013-09-01

    Pudendal neuralgia is an entrapment syndrome whose both anatomic landmarks and operative technique remain relatively unfamiliar to neurosurgeons. To provide an outline of operative steps that is important to correct application of this approach. Surgical illustrations are included. The different figures detail the important steps of the operation. We perform a transmuscular approach leading to the sacrotuberous ligament, which is opened sagittally. The pudendal nerve and internal pudendal artery are found to be enclosed by a fascia sheath. The pudendal nerve swings around the sacrospinous ligament sacrospinous ligament with tension. Both distal branches of the pudendal nerve can be followed, especially the rectal branch running medially. After the section of the sacrospinous ligament, the pudendal nerve can be transposed frontally to the ischial spine within the ischiorectal fat. During this maneuver, significant venous bleeding may be encountered as perineural satellite veins dilatation can accompany or surround the pudendal nerve. It is important to avoid overpacking to limit compression injury to the pudendal nerve using judiciously small pieces of hemostatic device and soft cottonoid with light pressure. Then, the obturator fascia and the membranous falciform process of the sacrotuberous ligament that extend toward the ischioanal fossa must be incised. Transgluteal approach is a safe technique and we demonstrate that this approach can be performed safely minimizing pain, size of incision, surgical corridor, and trauma to adjacent muscles of buttock.

  10. The combined effect of mathematics skills and formal operational reasoning on student performance in the general physics course

    NASA Astrophysics Data System (ADS)

    Hudson, H. T.; Liberman, Dov

    1982-12-01

    Precourse tests of computational skills in algebra and trigonometry and of formal operational reasoning have been correlated with performance in the algebra-based introductory physics course for 80 students. The correlation coefficient for mathematics and physics was 0.345 (p<0.001) and for formal operational reasoning and physics was 0.435 (p<0.001). However, a multiple regression analysis of the combined effect of mathematics and formal operational reasoning on the total physics grade yielded a multiple R of 0.518, R2=0.268. This study found that the combination of precourse measures of mathematics computational skills and abstract reasoning explained over 25% of the variance in the final physics grade distribution.

  11. A low cost commercial approach to space systems development and operations

    NASA Astrophysics Data System (ADS)

    Bonner, T. F.; Faget, M. A.; Allen, J. P.; Langstaff, D. H.

    In recent years a number of factors have led to increased attention to the lowering of costs for space flight systems and the operation of those systems. To that end Space Industries Inc. (SII), a small commercial space company based in Houston, Tex., is employing proven methods derived from over three decades of space flight development and space operations. These methods are based on a philosophy that is cost-sensitive focused with a primary objective to drive the cost of space systems and their operations down to the lowest level practical, consistent with the mission objectives, acceptable risk and safety considerations. This approach involves a process of: (1) addressing the basic requirements in the simplest and most cost effective manner, i.e. limit new development wherever possible, maximize use of proven and existing technology and eliminate non-essential requirements; (2) incorporation of proven industrial practices where possible, i.e. focus on performance envelopes (not on restrictive, specific and detailed specifications) and streamline program management, documentation, testing and other procedures; and (3) delivery of the "best" price, i.e. maximum customer utility at minimum cost with emphasis on customer service. The overriding factor, and indeed the most important aspect of the low cost commercial approach, is the willingness to accept greater risks to achieve all of the user's objectives. Our development approach is customer focused with emphasis on fully understanding the customer needs while striving constantly to limit new development requirements and, consequently, additional costs. This approach involves a process of designing for operations, i.e. low operation and life-cycle costs, while ensuring a reliability level consistent with customer budget constraints, mission objectives and safety consideration. In executing this low cost, customer-focused approach, we strive to maintain minimal overheads, simple interfaces, reduced documentation

  12. A Riemann-Hilbert approach to the inverse problem for the Stark operator on the line

    NASA Astrophysics Data System (ADS)

    Its, A.; Sukhanov, V.

    2016-05-01

    The paper is concerned with the inverse scattering problem for the Stark operator on the line with a potential from the Schwartz class. In our study of the inverse problem, we use the Riemann-Hilbert formalism. This allows us to overcome the principal technical difficulties which arise in the more traditional approaches based on the Gel’fand-Levitan-Marchenko equations, and indeed solve the problem. We also produce a complete description of the relevant scattering data (which have not been obtained in the previous works on the Stark operator) and establish the bijection between the Schwartz class potentials and the scattering data.

  13. Immunotherapy Combinations With Checkpoint Inhibitors in Metastatic Melanoma: Current Approaches and Future Directions.

    PubMed

    Atkins, Michael

    2015-12-01

    Based on the complexity of the immune response to cancer and the mechanisms of tumor evasion, it is likely that therapeutic modulation of multiple immune-mediated pathways will be needed to maximally induce tumor regression in patients with advanced melanoma. The rationale of using combination checkpoint inhibitor-based regimens may include the concomitant effects on re-activation of T cells, increased trafficking of tumor reactive lymphocytes into the tumor tissue, and enhanced killing of cancer cells. The administration of nivolumab in combination with ipilimumab demonstrated increased response rates, tumor shrinkage, and median progression-free survival using combined therapy compared with either treatment alone. Although toxicity was also increased, this trial established proof of principle that combination immunotherapy could enhance the efficacy seen with single-agent programmed cell death protein-1 (PD-1) pathway blockade for the unselected patient. Current and future trials are evaluating alternative schedules and other combinations of immunotherapies to determine if they could provide similar efficacy with less toxicity. In addition, efforts are underway to determine how best to integrate combination immunotherapy with other treatment approaches for patients with advanced melanoma.

  14. An instrumental approach to combining confocal microspectroscopy and 3D scanning probe nanotomography.

    PubMed

    Mochalov, Konstantin E; Chistyakov, Anton A; Solovyeva, Daria O; Mezin, Alexey V; Oleinikov, Vladimir A; Vaskan, Ivan S; Molinari, Michael; Agapov, Igor I; Nabiev, Igor; Efimov, Anton E

    2017-06-21

    In the past decade correlative microscopy, which combines the potentials of different types of high-resolution microscopies with a variety of optical microspectroscopy techniques, has been attracting increasing attention in material science and biological research. One of outstanding solutions in this area is the combination of scanning probe microscopy (SPM), which provides data on not only the topography, but also the spatial distribution of a wide range of physical properties (elasticity, conductivity, etc.), with ultramicrotomy, allowing 3D multiparametric examination of materials. The combination of SPM and ultramicrotomy (scanning probe nanotomography) is very appropriate for characterization of soft multicompound nanostructurized materials, such as polymer matrices and microstructures doped with different types of nanoparticles (magnetic nanoparticles, quantum dots, nanotubes, etc.), and biological materials. A serious problem of this technique is a lack of chemical and optical characterization tools, which may be solved by using optical microspectroscopy. Here, we report the development of an instrumental approach to combining confocal microspectroscopy and 3D scanning probe nanotomography in a single apparatus. This approach retains all the advantages of SPM and upright optical microspectroscopy and allows 3D multiparametric characterization using both techniques. As the first test of the system developed, we have performed correlative characterization of the morphology and the magnetic and fluorescent properties of fluorescent magnetic microspheres doped with a fluorescent dye and magnetic nanoparticles. The results of this study can be used to obtain 3D volume images of a specimen for most high-resolution near-field scanning probe microscopies: SNOM, TERS, AFM-IR, etc. This approach will result in development of unique techniques combining the advantages of SPM (nanoscale morphology and a wide range of physical parameters) and high-resolution optical

  15. Assessing human impact on droughts in a tropical Vietnamese catchment using a combined modelling approach

    NASA Astrophysics Data System (ADS)

    Nauditt, Alexandra; Birkel, Christian; Ribbe, Lars; Tran Van, Tra; Viet, Trinh Quoc; Firoz, Abm; Fink, Manfred

    2015-04-01

    Historical drought frequency, drought risk and types are still poorly investigated in tropical regions and particularly in South East Asia. However, evolving drought periods during the dry season severely impact on socio economic factors such as livelihood (irrigated rice production), hydropower generation and urban water supply in such regions as in the VuGiaThuBon river basin (10,350 km²) in Central Vietnam. Besides the increasing frequency of heat waves and prolonged dry periods without rainfall, hydropower development and over-exploitation of water resources due to demographic and socioeconomic development are the main causes for drought-related disasters and subsequent salt water intrusion. Precipitation and runoff time series from 1982 to 2009 were used to assess drought severity and typology before hydropower development started in 2010. We applied different rainfall-runoff modelling approaches of increasing complexity (HBV light, J2000 and Mike NAM) as well as meteorological and hydrological drought indices such as the Standardized Precipitation Index (SPI) and its runoff homologue (SRI). In the scope of the BMBF funded research project "Land use and Climate Change interactions (LUCCi)" (www.lucci-vietnam.info), the impacts of the human-induced hydrological alterations on drought risk were quantified by integrating the distributed physically-based hydrological model J2000 with the reservoir operation tool HEC ResSim and the River basin model Mike Basin to simulate the runoff to the coastal system. The salt water intrusion behavior in the flat coastal area was represented by the hydrodynamic Mike 11 model relating low flow thresholds to salt intrusion. The different discharge simulations before and after the reservoir construction were compared and evaluated regarding their relevance for the drought severity being dominated either by meteorological dry spells or hydrological alterations. Results show a clear impact of the hydropower reservoir and resulting

  16. Peri-operative treatment of anaemia in major orthopaedic surgery: a practical approach from Spain.

    PubMed

    Bisbe, Elvira; Basora, Misericordia; Colomina, María J

    2017-07-01

    In patients undergoing major orthopaedic surgery, pre-operative anaemia, peri-operative bleeding and a liberal transfusion policy are the main risk factors for requiring red blood cell transfusion (RBCT). The clinical and economic disadvantages of RBCT have led to the development and implementation of multidisciplinary, multimodal, individualised strategies, collectively termed patient blood management, which aim to reduce RBCT and improve patients' clinical outcome and safety. Within a patient blood management programme, low pre-operative haemoglobin is one of the few modifiable risk factors for RBCT. However, a survey among Anaesthesia Departments in Spain revealed that, although pre-operative assessment was performed in the vast majority of hospitals, optimisation of haemoglobin concentration was attempted in <40% of patients who may have benefitted from it, despite there being enough time prior to surgery. This indicates that haemoglobin optimisation takes planning and forethought to be implemented in an effective manner. This review, based on available clinical evidence and our experience, is intended to provide clinicians with a practical tool to optimise pre-operative haemoglobin levels, in order to minimise the risk of patients requiring RBCT. To this purpose, after reviewing the diagnostic value and limitations of available laboratory parameters, we developed an algorithm for the detection, classification and treatment of pre-operative anaemia, with a patient-tailored approach that facilitates decision-making in the pre-operative assessment. We also reviewed the efficacy of the different pharmacological options for pre-operative and post-operative management of anaemia. We consider that such an institutional pathway for anaemia management could be a viable, cost-effective strategy that is beneficial to both patients and healthcare systems.

  17. Change Detection in Uav Video Mosaics Combining a Feature Based Approach and Extended Image Differencing

    NASA Astrophysics Data System (ADS)

    Saur, Günter; Krüger, Wolfgang

    2016-06-01

    Change detection is an important task when using unmanned aerial vehicles (UAV) for video surveillance. We address changes of short time scale using observations in time distances of a few hours. Each observation (previous and current) is a short video sequence acquired by UAV in near-Nadir view. Relevant changes are, e.g., recently parked or moved vehicles. Examples for non-relevant changes are parallaxes caused by 3D structures of the scene, shadow and illumination changes, and compression or transmission artifacts. In this paper we present (1) a new feature based approach to change detection, (2) a combination with extended image differencing (Saur et al., 2014), and (3) the application to video sequences using temporal filtering. In the feature based approach, information about local image features, e.g., corners, is extracted in both images. The label "new object" is generated at image points, where features occur in the current image and no or weaker features are present in the previous image. The label "vanished object" corresponds to missing or weaker features in the current image and present features in the previous image. This leads to two "directed" change masks and differs from image differencing where only one "undirected" change mask is extracted which combines both label types to the single label "changed object". The combination of both algorithms is performed by merging the change masks of both approaches. A color mask showing the different contributions is used for visual inspection by a human image interpreter.

  18. Combination approaches to potentiate immune response after photodynamic therapy for cancer†

    PubMed Central

    St Denis, Tyler G.; Aziz, Kanza; Waheed, Anam A.; Huang, Ying-Ying; Sharma, Sulbha K.; Mroz, Pawel; Hamblin, Michael R.

    2012-01-01

    Photodynamic therapy (PDT) has been used as a cancer therapy for forty years but has not advanced to a mainstream cancer treatment. Although it has been shown to be an efficient way to destroy local tumors by a combination of non-toxic dyes and harmless visible light, it is its additional effects in mediating the stimulation of the host immune system that gives PDT great potential to become more widely used. Although the stimulation of tumor-specific cytotoxic T-cells that can destroy distant tumor deposits after PDT has been reported in some animal models, it remains the exception rather than the rule. This realization has prompted several investigators to test various combination approaches that could potentiate the immune recognition of tumor antigens that have been released after PDT. This review will cover these combination approaches using immunostimulants including various microbial preparations that activate Toll-like receptors and other receptors for pathogen-associated molecular patterns, cytokines growth factors, and approaches that target regulatory T-cells. We believe that by understanding the methods employed by tumors to evade immune response and neutralizing them, more precise ways of potentiating PDT-induced immunity can be devised. PMID:21479313

  19. Effectiveness of dereverberation, feature transformation, discriminative training methods, and system combination approach for various reverberant environments

    NASA Astrophysics Data System (ADS)

    Tachioka, Yuuki; Narita, Tomohiro; Watanabe, Shinji

    2015-12-01

    The recently released REverberant Voice Enhancement and Recognition Benchmark (REVERB) challenge includes a reverberant automatic speech recognition (ASR) task. This paper describes our proposed system based on multi-channel speech enhancement preprocessing and state-of-the-art ASR techniques. For preprocessing, we propose a single-channel dereverberation method with reverberation time estimation, which is combined with multichannel beamforming that enhances direct sound compared with the reflected sound. In addition, this paper also focuses on state-of-the-art ASR techniques such as discriminative training of acoustic models including the Gaussian mixture model, subspace Gaussian mixture model, and deep neural networks, as well as various feature transformation techniques. Although, for the REVERB challenge, it is necessary to handle various acoustic environments, a single ASR system tends to be overly tuned for a specific environment, which degrades the performance in the mismatch environments. To overcome this mismatch problem with a single ASR system, we use a system combination approach using multiple ASR systems with different features and different model types because a combination of various systems that have different error patterns is beneficial. In particular, we use our discriminative training technique for system combination that achieves better generalization by making systems complementary with the modified discriminative criteria. Experiments show the effectiveness of these approaches, reaching 6.76 and 18.60 % word error rates on the REVERB simulated and real test sets. These are 68.8 and 61.5 % relative improvements over the baseline.

  20. An Optimization Approach to Coexistence of Bluetooth and Wi-Fi Networks Operating in ISM Environment

    NASA Astrophysics Data System (ADS)

    Klajbor, Tomasz; Rak, Jacek; Wozniak, Jozef

    Unlicensed ISM band is used by various wireless technologies. Therefore, issues related to ensuring the required efficiency and quality of operation of coexisting networks become essential. The paper addresses the problem of mutual interferences between IEEE 802.11b transmitters (commercially named Wi-Fi) and Bluetooth (BT) devices.An optimization approach to modeling the topology of BT scatternets is introduced, resulting in more efficient utilization of ISM environment consisting of BT and Wi-Fi networks. To achieve it, the Integer Linear Programming approach has been proposed. Example results presented in the paper illustrate significant benefits of using the proposed modeling strategy.

  1. A Global Operator Approach to Wess-Zumino-Novikov-Witten models

    NASA Astrophysics Data System (ADS)

    Schlichenmaier, Martin

    2007-11-01

    We present a global operator approach to Wess-Zumino-Novikov models for compact Riemann surfaces of arbitrary genus g with N marked points. The approach is based on the multipoint Krichever-Novikov algebras of global meromorphic functions and vector fields, and the global algebras of affine type and their representations. Using the global Sugawara construction and the identification of a certain subspace of the vector field algebra with the tangent space to the moduli space of the geometric data, the Knizhnik-Zamalodchikov connection is defined. For fermionic representations it defines a projectively flat connection on the vector bundle of conformal blocks. The presented work is joint work with Oleg Sheinman.

  2. 78 FR 41118 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Radiological Source Terms for Evaluating Design Basis Accidents at Nuclear Power Reactors,'' by modifying the... Regulatory Commission. Michele G. Evans, Director, Division of Operating Reactor Licensing, Office of Nuclear... From the Federal Register Online via the Government Publishing Office NUCLEAR...

  3. The Operational Forecasting of Undesirable Pollution Levels Based on a Combined Pollution Index

    ERIC Educational Resources Information Center

    McAdie, H. G.; Gillies, D. K. A.

    1973-01-01

    Describes the application of an air pollution index, in conjunction with synoptic meteorological forecasting, to an operational program for forecasting pollution potential in the Sarnia (Ontario) petrochemical complex. (JR)

  4. 77 FR 67679 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... configuration and ensure Residual Heat Removal (RHR) system operability meets the TS 3.5.3 LCO requirement... loss of coolant accident (LOCA). Thus, the proposed deletion of the TS 3.5.3 LCO Note does not...

  5. An Evidenced-Based Approach for Estimating Decompression Sickness Risk in Aircraft Operations

    NASA Technical Reports Server (NTRS)

    Robinson, Ronald R.; Dervay, Joseph P.; Conkin, Johnny

    1999-01-01

    Estimating the risk of decompression Sickness (DCS) in aircraft operations remains a challenge, making the reduction of this risk through the development of operationally acceptable denitrogenation schedules difficult. In addition, the medical recommendations which are promulgated are often not supported by rigorous evaluation of the available data, but are instead arrived at by negotiation with the aircraft operations community, are adapted from other similar aircraft operations, or are based upon the opinion of the local medical community. We present a systematic approach for defining DCS risk in aircraft operations by analyzing the data available for a specific aircraft, flight profile, and aviator population. Once the risk of DCS in a particular aircraft operation is known, appropriate steps can be taken to reduce this risk to a level acceptable to the applicable aviation community. Using this technique will allow any aviation medical community to arrive at the best estimate of DCS risk for its specific mission and aviator population and will allow systematic reevaluation of the decisions regarding DCS risk reduction when additional data are available.

  6. Phytophagous Insects on Native and Non-Native Host Plants: Combining the Community Approach and the Biogeographical Approach

    PubMed Central

    Meijer, Kim; Zemel, Hidde; Chiba, Satoshi; Smit, Christian; Beukeboom, Leo W.; Schilthuizen, Menno

    2015-01-01

    During the past centuries, humans have introduced many plant species in areas where they do not naturally occur. Some of these species establish populations and in some cases become invasive, causing economic and ecological damage. Which factors determine the success of non-native plants is still incompletely understood, but the absence of natural enemies in the invaded area (Enemy Release Hypothesis; ERH) is one of the most popular explanations. One of the predictions of the ERH, a reduced herbivore load on non-native plants compared with native ones, has been repeatedly tested. However, many studies have either used a community approach (sampling from native and non-native species in the same community) or a biogeographical approach (sampling from the same plant species in areas where it is native and where it is non-native). Either method can sometimes lead to inconclusive results. To resolve this, we here add to the small number of studies that combine both approaches. We do so in a single study of insect herbivory on 47 woody plant species (trees, shrubs, and vines) in the Netherlands and Japan. We find higher herbivore diversity, higher herbivore load and more herbivory on native plants than on non-native plants, generating support for the enemy release hypothesis. PMID:25955254

  7. Phytophagous insects on native and non-native host plants: combining the community approach and the biogeographical approach.

    PubMed

    Meijer, Kim; Zemel, Hidde; Chiba, Satoshi; Smit, Christian; Beukeboom, Leo W; Schilthuizen, Menno

    2015-01-01

    During the past centuries, humans have introduced many plant species in areas where they do not naturally occur. Some of these species establish populations and in some cases become invasive, causing economic and ecological damage. Which factors determine the success of non-native plants is still incompletely understood, but the absence of natural enemies in the invaded area (Enemy Release Hypothesis; ERH) is one of the most popular explanations. One of the predictions of the ERH, a reduced herbivore load on non-native plants compared with native ones, has been repeatedly tested. However, many studies have either used a community approach (sampling from native and non-native species in the same community) or a biogeographical approach (sampling from the same plant species in areas where it is native and where it is non-native). Either method can sometimes lead to inconclusive results. To resolve this, we here add to the small number of studies that combine both approaches. We do so in a single study of insect herbivory on 47 woody plant species (trees, shrubs, and vines) in the Netherlands and Japan. We find higher herbivore diversity, higher herbivore load and more herbivory on native plants than on non-native plants, generating support for the enemy release hypothesis.

  8. A team leadership approach to managing the transition from construction to operations for an environmental project

    SciTech Connect

    Kelly, J.W.

    1994-06-01

    This presentation describes a team approach, at the totalproject level that focused team members with common objectives, for the transition to start-up and operation of the project. The Integrated Management Team (IMT) approach has been successful for this US Department of Energy (DOE) environmental restoration project at the Hanford Site in Richland, Washington. The $53.8-million project will collect, treat, and dispose of low-level mixed waste water discharges from the Hanford Site. Construction is scheduled for completion in September 1994 and facility start-up in June 1995. The project challenge is for leadership that is committed to the transition from construction to operation of the environmental restoration project.

  9. An operational approach to high resolution agro-ecological zoning in West-Africa

    PubMed Central

    Palminha, A.; Melo, I. Q.; Pereira, J. M. C.

    2017-01-01

    The objective of this work is to develop a simple methodology for high resolution crop suitability analysis under current and future climate, easily applicable and useful in Least Developed Countries. The approach addresses both regional planning in the context of climate change projections and pre-emptive short-term rural extension interventions based on same-year agricultural season forecasts, while implemented with off-the-shelf resources. The developed tools are applied operationally in a case-study developed in three regions of Guinea-Bissau and the obtained results, as well as the advantages and limitations of methods applied, are discussed. In this paper we show how a simple approach can easily generate information on climate vulnerability and how it can be operationally used in rural extension services. PMID:28873392

  10. An operational approach to high resolution agro-ecological zoning in West-Africa.

    PubMed

    Le Page, Y; Vasconcelos, Maria; Palminha, A; Melo, I Q; Pereira, J M C

    2017-01-01

    The objective of this work is to develop a simple methodology for high resolution crop suitability analysis under current and future climate, easily applicable and useful in Least Developed Countries. The approach addresses both regional planning in the context of climate change projections and pre-emptive short-term rural extension interventions based on same-year agricultural season forecasts, while implemented with off-the-shelf resources. The developed tools are applied operationally in a case-study developed in three regions of Guinea-Bissau and the obtained results, as well as the advantages and limitations of methods applied, are discussed. In this paper we show how a simple approach can easily generate information on climate vulnerability and how it can be operationally used in rural extension services.

  11. Combined Endonasal-Transcervical Approach to a Metastatic Parapharyngeal Space Papillary Thyroid Carcinoma

    PubMed Central

    Benet, Arnau; El-Sayed, Ivan

    2015-01-01

    Purpose: Although papillary thyroid carcinoma metastases to the parapharyngeal space are rare, the high amount of fat tissue allows tumors to grow clinically undetectable until they invade most of the parapharyngeal space. We describe for the first time a combined endonasal and transcervical approach for a parapharyngeal metastasis from a papillary thyroid carcinoma. Materials and Methods: A 51-year-old male with a previous history of papillary thyroid carcinoma presented with left ear fullness and left-sided facial numbness. Imaging revealed a 4x3 cm pre-styloid parapharyngeal space mass invading the foramen ovale and extending below the palate. Needle biopsy confirmed metastatic papillary thyroid carcinoma. Results: The lesion was resected with a combined endoscopic endonasal and transcervical approach. Postoperative MRI revealed gross total resection, and the patient recovered from his symptoms. Conclusion: This novel approach provides access to pre-styloid parapharyngeal tumors with superior extension to the skull base, avoiding more extensive traditional open approaches. PMID:26203403

  12. Combined endoscopic transforaminal-transchoroidal approach for the treatment of third ventricle colloid cysts.

    PubMed

    Iacoangeli, Maurizio; di Somma, Lucia Giovanna Maria; Di Rienzo, Alessandro; Alvaro, Lorenzo; Nasi, Davide; Scerrati, Massimo

    2014-06-01

    Colloid cysts are histologically benign lesions whose primary goal of treatment should be complete resection to avoid recurrence and sudden death. Open surgery is traditionally considered the standard approach, but, recently, the endoscopic technique has been recognized as a viable and safe alternative to microsurgery. The endoscopic approach to colloid cysts of the third ventricle is usually performed through the foramen of Monro. However, this route does not provide adequate visualization of the cyst attachment on the tela choroidea. The combined endoscopic transforaminal-transchoroidal approach (ETTA), providing exposure of the entire cyst and a better visualization of the tela choroidea, could increase the chances of achieving a complete cyst resection. Between April 2005 and February 2011, 19 patients with symptomatic colloid cyst of the third ventricle underwent an endoscopic transfrontal-transforaminal approach. Five of these patients, harboring a cyst firmly adherent to the tela choroidea or attached to the middle/posterior roof of the third ventricle, required a combined ETTA. Postoperative MRI documented a gross-total resection in all 5 cases. There were no major complications and only 1 patient experienced a transient worsening of the memory deficit. To date, no cyst recurrence has been observed. An ETTA is a minimally invasive procedure that can allow for a safe and complete resection of third ventricle colloid cysts, even in cases in which the lesions are firmly attached to the tela choroidea or located in the middle/posterior roof of the third ventricle.

  13. Use of Combined Biogeochemical Model Approaches and Empirical Data to Assess Critical Loads of Nitrogen

    SciTech Connect

    Fenn, Mark E.; Driscoll, Charles; Zhou, Qingtao; Rao, Leela E.; Meixner, Tom; Allen, Edith B.; Yuan, Fengming; Sullivan, Timothy J.

    2015-01-01

    Empirical and dynamic biogeochemical modelling are complementary approaches for determining the critical load (CL) of atmospheric nitrogen (N) or other constituent deposition that an ecosystem can tolerate without causing ecological harm. The greatest benefits are obtained when these approaches are used in combination. Confounding environmental factors can complicate the determination of empirical CLs across depositional gradients, while the experimental application of N amendments for estimating the CL does not realistically mimic the effects of chronic atmospheric N deposition. Biogeochemical and vegetation simulation models can provide CL estimates and valuable ecosystem response information, allowing for past and future scenario testing with various combinations of environmental factors, pollutants, pollutant control options, land management, and ecosystem response parameters. Even so, models are fundamentally gross simplifications of the real ecosystems they attempt to simulate. Empirical approaches are vital as a check on simulations and CL estimates, to parameterize models, and to elucidate mechanisms and responses under real world conditions. In this chapter, we provide examples of empirical and modelled N CL approaches in ecosystems from three regions of the United States: mixed conifer forest, desert scrub and pinyon- juniper woodland in California; alpine catchments in the Rocky Mountains; and lakes in the Adirondack region of New York state.

  14. Giant Petrous Bone Cholesteatoma: Combined Microscopic Surgery and an Adjuvant Endoscopic Approach.

    PubMed

    Iannella, Giannicola; Savastano, Ersilia; Pasquariello, Benedetta; Re, Massimo; Magliulo, Giuseppe

    2016-03-01

    Petrous bone cholesteatomas (PBCs) are epidermoid cysts, which have developed in the petrous portion of the temporal bone and may be congenital or acquired. Cholesteatomas arising in this region have a tendency to invade bone and functional structures and the middle and posterior fossae reaching an extensive size. Traditionally, surgery of a giant PBC contemplates lateral transtemporal or middle fossa microscopic surgery; however, in recent years, endoscopic surgical techniques (primary or complementary endoscopic approach) are starting to receive a greater consensus for middle ear and mastoid surgeries. We report the rare case of an 83-year-old Caucasian male affected by a giant cholesteatoma that eroded the labyrinth and the posterior fossa dura and extended to the infralabyrinthine region, going beyond the theca and reaching the first cervical vertebra. The giant cholesteatoma was managed through a combined approach (microscopic and, subsequently, complementary endoscopic approach). In this case report, we illustrate some advantages of this surgical choice.

  15. Giant Petrous Bone Cholesteatoma: Combined Microscopic Surgery and an Adjuvant Endoscopic Approach

    PubMed Central

    Iannella, Giannicola; Savastano, Ersilia; Pasquariello, Benedetta; Re, Massimo; Magliulo, Giuseppe

    2016-01-01

    Petrous bone cholesteatomas (PBCs) are epidermoid cysts, which have developed in the petrous portion of the temporal bone and may be congenital or acquired. Cholesteatomas arising in this region have a tendency to invade bone and functional structures and the middle and posterior fossae reaching an extensive size. Traditionally, surgery of a giant PBC contemplates lateral transtemporal or middle fossa microscopic surgery; however, in recent years, endoscopic surgical techniques (primary or complementary endoscopic approach) are starting to receive a greater consensus for middle ear and mastoid surgeries. We report the rare case of an 83-year-old Caucasian male affected by a giant cholesteatoma that eroded the labyrinth and the posterior fossa dura and extended to the infralabyrinthine region, going beyond the theca and reaching the first cervical vertebra. The giant cholesteatoma was managed through a combined approach (microscopic and, subsequently, complementary endoscopic approach). In this case report, we illustrate some advantages of this surgical choice. PMID:26937334

  16. Combining imaging with microbiopsy enables a more comprehensive approach for topical drug research (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Prow, Tarl W.

    2017-02-01

    Topical drug delivery is a challenging research field, but quantifying topical drug delivery also has significant challenges, especially in the clinical studies. Both cosmeceutical and pharmaceutical endpoints largely drive research in this area. Conventional drug delivery approaches primarily rely on testing trans dermal drug kinetics using excised skin in Franz cells. Thus is a largely unmet need for non- and minimally invasive approaches to evaluate topical drug delivery and efficacy in excised and volunteer skin. We are meeting this need through the development of non-invasive imaging based approaches such as fluorescent dermoscopy, fluorescence scanning and confocal microscopy followed by image analysis. Minimally invasive microbiopsies are being used to extract drug concentrations from tiny pieces of skin without the need for local anaesthetics and without scars. This combined strategy enables us to collect drug disposition information in addition to skin morphology and molecular characterisation which provides a more dynamic and comprehensive way to examine drug deliver, effects of enhancement technologies and efficacy.

  17. Consideration of proper operative route for interlaminar approach for percutaneous endoscopic lumbar discectomy

    PubMed Central

    Tonosu, Juichi; Oshima, Yasushi; Shiboi, Ryutaro; Hayashi, Akihiko; Takano, Yuichi; Inanami, Hirohiko

    2016-01-01

    Background Percutaneous endoscopic lumbar discectomy (PELD) is one of the less invasive treatments of lumbar disc herniation (LDH), and has three different operative approaches. This study focused on the interlaminar approach (ILA) and investigated the appropriate operative route for this approach. Methods ILA was performed in 41 patients with LDH. The width of the interlaminar space, LDH size, and positional relation between LDH and the corresponding nerve root were radiologically evaluated. Thirty-three LDHs were removed via the shoulder of the corresponding nerve root and eight were removed via the axilla of the corresponding nerve root and dural sac. Pre- and postoperative status were evaluated using the modified Japanese Orthopedic Association (mJOA) and numerical rating scale (NRS) scores. Results The mean age was 41.5 years; there was single-level involvement, mostly at L5/S1 (33 cases). The mean recovery rate of mJOA score was 59.8% and mean pre- and postoperative NRS scores were 5.8 and 0.98, respectively. Relatively severe complications developed in three patients treated by ILA via the shoulder. There was persistent numbness in the corresponding nerve area, transient muscular weakness, and transient bladder and rectal disturbance, may be due to excessive compression of the nerve root and/or dural sac by the endoscopic sheath. Conclusions ILA can be used to treat LDH revealing an interlaminar space of ≥20 mm. The procedure is minimally invasive and effective; however, appropriate selection of an operative route is important to avoid operative complications. Particularly for large LDH, the operative route via the axilla should be considered. PMID:28097245

  18. Operations

    ERIC Educational Resources Information Center

    Wilkins, Jesse L. M.; Norton, Anderson; Boyce, Steven J.

    2013-01-01

    Previous research has documented schemes and operations that undergird students' understanding of fractions. This prior research was based, in large part, on small-group teaching experiments. However, written assessments are needed in order for teachers and researchers to assess students' ways of operating on a whole-class scale. In this study,…

  19. Optimization of Multiple-Purpose Reservoir Systems Operations: A Review of Modeling and Analysis Approaches

    DTIC Science & Technology

    1991-01-01

    The model determines on a weekly basis the supply of water available to each of the three jurisdictions resulting from previous decisions made in...Chow), Academic Press, New York, N.Y., 1981. Kuczera, G., and G. Diment, "General Water Supply System Simulation Model : WASP," Journal of Water Resources...Unlimited. ....----- 91 5 10 031 Optimization of Multiple-Purpose Reservoir System Operations: A Review of Modeling and Analysis Approaches Accession For

  20. Creating Situational Awareness in Spacecraft Operations with the Machine Learning Approach

    NASA Astrophysics Data System (ADS)

    Li, Z.

    2016-09-01

    This paper presents a machine learning approach for the situational awareness capability in spacecraft operations. There are two types of time dependent data patterns for spacecraft datasets: the absolute time pattern (ATP) and the relative time pattern (RTP). The machine learning captures the data patterns of the satellite datasets through the data training during the normal operations, which is represented by its time dependent trend. The data monitoring compares the values of the incoming data with the predictions of machine learning algorithm, which can detect any meaningful changes to a dataset above the noise level. If the difference between the value of incoming telemetry and the machine learning prediction are larger than the threshold defined by the standard deviation of datasets, it could indicate the potential anomaly that may need special attention. The application of the machine-learning approach to the Advanced Himawari Imager (AHI) on Japanese Himawari spacecraft series is presented, which has the same configuration as the Advanced Baseline Imager (ABI) on Geostationary Environment Operational Satellite (GOES) R series. The time dependent trends generated by the data-training algorithm are in excellent agreement with the datasets. The standard deviation in the time dependent trend provides a metric for measuring the data quality, which is particularly useful in evaluating the detector quality for both AHI and ABI with multiple detectors in each channel. The machine-learning approach creates the situational awareness capability, and enables engineers to handle the huge data volume that would have been impossible with the existing approach, and it leads to significant advances to more dynamic, proactive, and autonomous spacecraft operations.

  1. Kinetic Rate Kernels via Hierarchical Liouville-Space Projection Operator Approach.

    PubMed

    Zhang, Hou-Dao; Yan, YiJing

    2016-05-19

    Kinetic rate kernels in general multisite systems are formulated on the basis of a nonperturbative quantum dissipation theory, the hierarchical equations of motion (HEOM) formalism, together with the Nakajima-Zwanzig projection operator technique. The present approach exploits the HEOM-space linear algebra. The quantum non-Markovian site-to-site transfer rate can be faithfully evaluated via projected HEOM dynamics. The developed method is exact, as evident by the comparison to the direct HEOM evaluation results on the population evolution.

  2. Give Design a Chance: A Case for a Human Centered Approach to Operational Art

    DTIC Science & Technology

    2017-05-25

    rather than fighting a strategy based on political and human dimensions within the current environment and with the adversary. Organizational behavior...the breadth and speed of human interaction and interconnectivity, in its various forms, is a contributing factor in societal complexity experienced...Give Design a Chance: A Case for a Human Centered Approach to Operational Art A Monograph by LTC Tyler K. Andersen US Army School of

  3. Bankruptcy Problem Approach to Load-Shedding in Agent-Based Microgrid Operation

    NASA Astrophysics Data System (ADS)

    Kim, Hak-Man; Kinoshita, Tetsuo; Lim, Yujin; Kim, Tai-Hoon

    Research, development, and demonstration projects on microgrids have been progressed in many countries. Furthermore, microgrids are expected to introduce into power grids as eco-friendly small-scale power grids in the near future. Load-shedding is a problem not avoided to meet power balance between power supply and power demand to maintain specific frequency such as 50 Hz or 60 Hz. Load-shedding causes consumers inconvenience and therefore should be performed minimally. Recently, agent-based microgrid operation has been studied and new algorithms for their autonomous operation including load-shedding has been required. The bankruptcy problem deals with distribution insufficient sources to claimants. In this paper, we approach the load-shedding problem as a bankruptcy problem and adopt the Talmud rule as an algorithm. Load-shedding using the Talmud rule is tested in islanded microgrid operation based on a multiagent system.

  4. Bearing fault identification by higher order energy operator fusion: A non-resonance based approach

    NASA Astrophysics Data System (ADS)

    Faghidi, H.; Liang, M.

    2016-10-01

    We report a non-resonance based approach to bearing fault detection. This is achieved by a higher order energy operator fusion (HOEO_F) method. In this method, multiple higher order energy operators are fused to form a single simple transform to process the bearing signal obscured by noise and vibration interferences. The fusion is guided by entropy minimization. Unlike the popular high frequency resonance technique, this method does not require the information of resonance excited by the bearing fault. The effects of the HOEO_F method on signal-to-noise ratio (SNR) and signal-to-interference ratio (SIR) are illustrated in this paper. The performance of the proposed method in handling noise and interferences has been examined using both simulated and experimental data. The results indicate that the HOEO_F method outperforms both the envelope method and the original energy operator method.

  5. Quantum Operator Approach Applied to the Position-Dependent Mass Schrödinger Equation

    NASA Astrophysics Data System (ADS)

    Ovando, G.; Peña, J. J.; Morales, J.

    2014-03-01

    In this work, the quantum operator approach is applied to both, the position-dependent mass Schrödinger equation (PDMSE) and the Schrodinger equation with constant mass (CMSE). This fact enable us to find the factorization operators that relates both Hamiltonians by means of a kinetic energy operator that comes from the proposal of Morrow and Brownstein. With this approach is possible to find the exactly-solvable PDMSE, for any value of the parameters α and γ in the von Roos's Hamiltonian. For that, our proposal can be considered as a unified treatment of the PDMSE because it contains as particular cases, the kinetic energy operators of various authors such as BenDaniel-Duke, Gora-Williams, Zhu-Kroemer and Li-Kuhn among others. To show the usefulness of our result, we show the solvable PDMSE that comes from the harmonic oscillator potential model for the CMSE. The proposal is general and can easily be extended to other potential models and mass distributions which will be given in the extended paper.

  6. A Systematic Approach for Real-Time Operator Functional State Assessment

    NASA Technical Reports Server (NTRS)

    Zhang, Guangfan; Wang, Wei; Pepe, Aaron; Xu, Roger; Schnell, Thomas; Anderson, Nick; Heitkamp, Dean; Li, Jiang; Li, Feng; McKenzie, Frederick

    2012-01-01

    A task overload condition often leads to high stress for an operator, causing performance degradation and possibly disastrous consequences. Just as dangerous, with automated flight systems, an operator may experience a task underload condition (during the en-route flight phase, for example), becoming easily bored and finding it difficult to maintain sustained attention. When an unexpected event occurs, either internal or external to the automated system, the disengaged operator may neglect, misunderstand, or respond slowly/inappropriately to the situation. In this paper, we discuss an approach for Operator Functional State (OFS) monitoring in a typical aviation environment. A systematic ground truth finding procedure has been designed based on subjective evaluations, performance measures, and strong physiological indicators. The derived OFS ground truth is continuous in time compared to a very sparse estimation of OFS based on an expert review or subjective evaluations. It can capture the variations of OFS during a mission to better guide through the training process of the OFS assessment model. Furthermore, an OFS assessment model framework based on advanced machine learning techniques was designed and the systematic approach was then verified and validated with experimental data collected in a high fidelity Boeing 737 simulator. Preliminary results show highly accurate engagement/disengagement detection making it suitable for real-time applications to assess pilot engagement.

  7. Operative techniques of percutaneous endoscopic mini-hemilaminectomy using a uniportal approach in dogs.

    PubMed

    Moon, Hee-Sup; Hwang, Yong-Hyun; Lee, Hee-Chun; Lee, Jae-Hoon

    2017-09-12

    The present study aimed to investigate the technical feasibility of percutaneous endoscopic mini-hemilaminectomy via a uniportal approach, and to evaluate the possibility of decompression and endoscopic examination of the thoracic and lumbar spinal canals in small dogs during such procedures. Fresh canine cadavers of mixed-breed dogs (n=7) were used in this study. Following injection of a barium and agarose mixture (BA-gel) to stimulate intervertebral disc herniation, percutaneous endoscopic mini-hemilaminectomy was performed using a lateral approach to the thoracic and lumbar vertebrae. BA-gel was removed to decompress the spinal cord using an elevator and rongeurs after mini-hemilaminectomy. Pre and post-operative computed tomography (CT) scans were obtained to evaluate surgical outcomes. Intra-operative complications, incision length, and procedure time were recorded. All procedures were completed with clear visualization of the spinal cord and floor of the spinal canal. The mean total operating time was 58.00 ± 18.06 min. Lengths of incision were under 1 cm in all dogs. Intra-operative complications included iatrogenic nerve root injuries caused by the micro-rongeur in two dogs. CT imaging revealed that removal of BA-gel resulted in sufficient spinal cord decompression. Our findings indicated that percutaneous endoscopic thoracolumbar mini-hemilaminectomy is feasible for spinal cord decompression and allows for adequate observation of the spinal canal. Thus, this technique may be an alternative surgical option for treatment of thoracolumbar disk disease in dogs.

  8. Operator approach to effective medium theory to overcome a breakdown of Maxwell Garnett approximation

    NASA Astrophysics Data System (ADS)

    Popov, Vladislav; Lavrinenko, Andrei V.; Novitsky, Andrey

    2016-08-01

    We elaborate on an operator approach to effective medium theory for homogenization of the periodic multilayered structures composed of nonmagnetic isotropic materials, which is based on equating the spatial evolution operators for the original structure and its effective alternative. We show that the zeroth-, first-, and second-order approximations of the operator effective medium theory correspond to electric dipoles, chirality, and magnetic dipoles plus electric quadrupoles, respectively. We discover that the spatially dispersive bianisotropic effective medium obtained in the second-order approximation perfectly replaces a multilayered composite and does not suffer from the effective medium approximation breakdown that happened near the critical angle of total internal reflection found previously in the conventional effective medium theory. We establish the criterion of the validity of the conventional effective medium theory depending on the ratio of unit-cell length to the wavelength, the number of unit cells, and the angle of incidence. The operator approach to effective medium theory is applicable for periodic and nonperiodic layered systems, being a fruitful tool in the fields of metamaterials and subwavelength nanophotonics.

  9. Mapping tillage operations over a peri-urban region using combined SPOT4 and ASAR/ENVISAT images

    NASA Astrophysics Data System (ADS)

    Vaudour, E.; Baghdadi, N.; Gilliot, J. M.

    2014-05-01

    This study aimed at assessing the potential of combining synchronous SPOT4 and ENVISAT/ASAR images (HH and HV polarizations) for mapping tillage operations (TOs) of bare agricultural fields over a peri-urban area characterized by conventional tillage system in the western suburbs of Paris (France). The reference spatial units for spatial modeling are 57 within-field areas named “reference zones” (RZs) homogeneous for their soil properties, constructed in the vicinity of 57 roughness measurement locations, spread across 20 agricultural fields for which TOs were known. The total RZ dataset was half dedicated to successive random selections of training/validating RZs, the remaining half (29 RZs) being kept for validating the final map results. Five supervised per-pixels classifiers were used in order to map 2 TOs classes (seedbed&harrowed and late winter plough) in addition to 4 landuse classes (forest, urban, crops and grass, water bodies): support vector machine with polynomial kernel (pSVM), SVM with radial basis kernel (rSVM), artificial neural network (ANN), Maximum Likelihood (ML), and regression tree (RT). All 5 classifiers were implemented in a bootstrapping approach in order to assess the uncertainty of map results. The best results were obtained with pSVM for the SPOT4/ASAR pair with producer's and user's mean validation accuracies (PmVA/UmVA) of 91.7%/89.8% and 73.2%/73.3% for seedbed&harrowed and late winter plough conditions, respectively. Whatever classifier, the SPOT4/ASAR pair appeared to perform better than each of the single images, particularly for late winter plough: PmVA/UmVA of 61.6%/53.0% for the single SPOT4 image; 0%/6% for the single ASAR image. About 73% of the validation agricultural fields (79% of the RZs) were correctly predicted in terms of TOs in the best pSVM-derived final map. Final map results could be improved through masking non-agricultural areas with land use identification system layer prior to classifying images. Such

  10. Future Directions in Myelodysplastic Syndrome: Newer Agents and the Role of Combination Approaches

    PubMed Central

    Gore, Steven D.; Hermes-DeSantis, Evelyn R.

    2009-01-01

    Myelodysplastic syndrome (MDS) is not a single disease, but a collection of hematopoietic disorders that require newer strategies. Currently, azacitidine, decitabine, and lenalidomide are approved by the US Food and Drug Administration for the treatment of MDS. A recent study demonstrated an improved overall survival (24.4 months vs 15 months) in high-risk MDS patients receiving azacitidine plus best supportive care vs conventional care which has resulted in an updated label for this product. Conventional care consisted of supportive care alone or either low-dose ara-C or standard chemotherapy plus best supportive care. While these data are encouraging, newer agents such as vorinostat, MGCD0103, MS-275, and tipifarnib are currently being studied as monotherapy or in combinations with approved treatments for MDS. The goal of combining pharmacotherapy, such as the combination of DNA methylation inhibitors and histone deacetylase inhibitors, in the management of MDS is to increase the response rates and decrease the toxicities associated with treatment. Clinical experience in the use of combination products has given practitioners the empirical knowledge necessary to better treat patients with MDS. Utilizing convergent or complementary molecular mechanisms with in vitro or in vivo evidence of synergy is a fresher and maybe a more efficacious approach to combination therapy. PMID:18813208

  11. Efficacy of Aliskiren/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Meta-Analytical Approach

    PubMed Central

    Morgado, Manuel P; Rolo, Sandra A; Castelo-Branco, Miguel

    2011-01-01

    Background: Single-pill combinations of aliskiren/hydrochlorothiazide have recently been approved by the European Medicines Agency for the treatment of hypertension. Objective: This study aimed to assess the antihypertensive efficacy of aliskiren/hydrochlorothiazide combination in reducing systolic and diastolic blood pressure in hypertensive patients. Methods: A search in International Pharmaceutical Abstracts, MEDLINE, The Cochrane Library and ISI Web of Knowledge was performed from 2000 to November 2009, to identify randomized, double-blind, clinical trials using aliskiren/hydrochlorothiazide for the treatment of hypertension. Studies were included if they evaluated the antihypertensive efficacy of aliskiren/hydrochlorothiazide in patients with mild or moderate essential hypertension and age ≥ 18 years. The meta-analytical approach calculated the weighted average reductions of systolic and diastolic blood pressure for each daily dosage combination. Results: We included 5 clinical trials testing several combinations of aliskiren/hydrochlorothiazide and containing data on 5448 patients. In all studies blood pressure was assessed at inclusion (baseline) and after 8 weeks of therapy. Blood pressure reductions and control rates were significantly (p < 0.05) higher with the aliskiren/hydrochlorothiazide combinations than with placebo and the same doses of aliskiren or hydrochlorothiazide alone. The weighted mean reductions (mm Hg) from baseline of systolic and diastolic blood pressure for each aliskiren/hydrochlorothiazide combination were: -15.8/-10.3 (150/25 mg); -15.9/-11.8 (300/12.5 mg); -16.9/-11.6 (300/25 mg). Blood pressure control rates (%) for the above combinations were, at least, respectively: 43.8, 50.1 and 51.9. Conclusions: Aliskiren/hydrochlorothiazide provided clinically significant additional blood pressure reductions and improved blood pressure control rates over aliskiren or hydrochlorothiazide monotherapy. PMID:21660247

  12. [MATCHE: Management Approach to Teaching Consumer and Homemaking Education.] Occupational Strand: Foods and Nutrition. Module II-C-2: Operations and Activities of a Food Service Operation.

    ERIC Educational Resources Information Center

    Waskey, Frank

    This competency-based preservice home economics teacher education module on operations and activities of a food service operation is the second in a set of three modules on occupational education relating to foods and nutrition. (This set is part of a larger series of sixty-seven modules on the Management Approach to Teaching Consumer and…

  13. Structure-oriented versus process-oriented approach to enhance efficiency for emergency room operations: what lessons can we learn?

    PubMed

    Hwang, Taik Gun; Lee, Younsuk; Shin, Hojung

    2011-01-01

    The efficiency and quality of a healthcare system can be defined as interactions among the system structure, processes, and outcome. This article examines the effect of structural adjustment (change in floor plan or layout) and process improvement (critical pathway implementation) on performance of emergency room (ER) operations for acute cerebral infarction patients. Two large teaching hospitals participated in this study: Korea University (KU) Guro Hospital and KU Anam Hospital. The administration of Guro adopted a structure-oriented approach in improving its ER operations while the administration of Anam employed a process-oriented approach, facilitating critical pathways and protocols. To calibrate improvements, the data for time interval, length of stay, and hospital charges were collected, before and after the planned changes were implemented at each hospital. In particular, time interval is the most essential measure for handling acute stroke patients because patients' survival and recovery are affected by the promptness of diagnosis and treatment. Statistical analyses indicated that both redesign of layout at Guro and implementation of critical pathways at Anam had a positive influence on most of the performance measures. However, reduction in time interval was not consistent at Guro, demonstrating delays in processing time for a few processes. The adoption of critical pathways at Anam appeared more effective in reducing time intervals than the structural rearrangement at Guro, mainly as a result of the extensive employee training required for a critical pathway implementation. Thus, hospital managers should combine structure-oriented and process-oriented strategies to maximize effectiveness of improvement efforts.

  14. Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes

    PubMed Central

    Kwon, Jea; An, Heeyoung; Sa, Moonsun; Won, Joungha; Shin, Jeong Im

    2017-01-01

    Astrocytes are non-excitable cells in the brain and their activity largely depends on the intracellular calcium (Ca2+) level. Therefore, maintaining the intracellular Ca2+ homeostasis is critical for proper functioning of astrocytes. One of the key regulatory mechanisms of Ca2+ homeostasis in astrocytes is the store-operated Ca2+ entry (SOCE). This process is mediated by a combination of the Ca2+-store-depletion-sensor, Stim, and the store-operated Ca2+-channels, Orai and TrpC families. Despite the existence of all those families in astrocytes, previous studies have provided conflicting results on the molecular identification of astrocytic SOCE. Here, using the shRNA-based gene-silencing approach and Ca2+-imaging from cultured mouse astrocytes, we report that Stim1 in combination with Orai1 and Orai3 contribute to the major portion of astrocytic SOCE. Gene-silencing of Stim1 showed a 79.2% reduction of SOCE, indicating that Stim1 is the major Ca2+-store-depletion-sensor. Further gene-silencing showed that Orai1, Orai2, Orai3, and TrpC1 contribute to SOCE by 35.7%, 20.3%, 26.8% and 12.2%, respectively. Simultaneous gene-silencing of all three Orai subtypes exhibited a 67.6% reduction of SOCE. Based on the detailed population analysis, we predict that Orai1 and Orai3 are expressed in astrocytes with a large SOCE, whereas TrpC1 is exclusively expressed in astrocytes with a small SOCE. This analytical approach allows us to identify the store operated channel (SOC) subtype in each cell by the degree of SOCE. Our results propose that Stim1 in combination with Orai1 and Orai3 are the major molecular components of astrocytic SOCE under various physiological and pathological conditions. PMID:28243166

  15. Organochlorine pesticides and polychlorinated biphenyls: An analytical approach for ``combined`` analyses

    SciTech Connect

    O`Neal, J.M.; Allgood, J.C.; Benson, W.H.

    1994-12-31

    Analysis or organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs) using gas chromatography (GC) can be tedious and time consuming. One problem has been a need to separate the sample into two fractions before analysis because of problems with resolution. The second is that because of the extreme sensitivity of ECD detectors, strict operating parameters must be maintained. In response to these issues, the authors have developed a ``combined`` method to analyze OC pesticides and PCBs. Using a combination of temperature programming and column size, baseline resolution of 17 pesticides, 21 PCB congeners, and 2 internal standards can be achieved in a single GC run. By use of a spiked-laboratory control material, recoveries of the individual analytes may be monitored for quality control.

  16. Circumferential Reconstruction of Subaxial Cervical and Cervicothoracic Spine by Simultaneously Combined Anterior-posterior Approaches in the Sitting Position.

    PubMed

    Han, Yue; Ma, Xin-Long; Hu, Yong-Cheng; Miao, Jun; Zhang, Ji-Dong; Bai, Jian-Qiang; Xia, Qun

    2017-08-01

    To introduce and analyze the feasibility of a new surgical strategy for circumferential reconstruction of subaxial cervical and cervicothoracic spine by simultaneously combined anterior-posterior approach in the sitting position. A retrospective review was performed for seven patients who underwent the above surgical procedure between July 2011 and January 2015. Among the seven patients, there were six men and one woman, with an average age of 52 years (range, 36-79 years). Six patients were confirmed to have a lower subaxial cervical fracture and dislocation with a locked facet joint, and the other patient had an invasive tumor involving both anterior and posterior parts of vertebrae and lamina, detected by radiological examination. The levels involved for all patients were from C4 to T2 . According to American Spinal Injury Association (ASIA) classification, one case was class A, four were class B, and two were class D. The patients were restricted in the sitting position with traction and a halo in extension to immobilize the head during the operation. The simultaneously combined anterior-posterior operation for reduction, decompression or tumor resection and circumferential reconstruction was carried out. Both anterior and posterior procedures were successfully completed simultaneously in the sitting position in all cases. There were no perioperative complications. The average operative time was 175 ± 32 min (range, 120-240 min), and the mean blood loss was 430 ± 85 mL (range, 200-1100 mL). The patients were followed up for 35.8 months (range, 18-60 months). The symptom of neck pain improved distinctly and no evidence of implant failure was noted in any patients. Neurological status improvement was confirmed in six patients, who had suffered incomplete paralysis. The ASIA grade improved in five patients, and two cases had no change in grade. The "sitting position" simultaneously combined anterior-posterior approach is safe and is

  17. Operational flight evaluation of the two-segment approach for use in airline service

    NASA Technical Reports Server (NTRS)

    Schwind, G. K.; Morrison, J. A.; Nylen, W. E.; Anderson, E. B.

    1975-01-01

    United Airlines has developed and evaluated a two-segment noise abatement approach procedure for use on Boeing 727 aircraft in air carrier service. In a flight simulator, the two-segment approach was studied in detail and a profile and procedures were developed. Equipment adaptable to contemporary avionics and navigation systems was designed and manufactured by Collins Radio Company and was installed and evaluated in B-727-200 aircraft. The equipment, profile, and procedures were evaluated out of revenue service by pilots representing government agencies, airlines, airframe manufacturers, and professional pilot associations. A system was then placed into scheduled airline service for six months during which 555 two-segment approaches were flown at three airports by 55 airline pilots. The system was determined to be safe, easy to fly, and compatible with the airline operational environment.

  18. Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4

    NASA Astrophysics Data System (ADS)

    Voet, Arnout R. D.; Kumar, Ashutosh; Berenger, Francois; Zhang, Kam Y. J.

    2014-04-01

    The SAMPL challenges provide an ideal opportunity for unbiased evaluation and comparison of different approaches used in computational drug design. During the fourth round of this SAMPL challenge, we participated in the virtual screening and binding pose prediction on inhibitors targeting the HIV-1 integrase enzyme. For virtual screening, we used well known and widely used in silico methods combined with personal in cerebro insights and experience. Regular docking only performed slightly better than random selection, but the performance was significantly improved upon incorporation of additional filters based on pharmacophore queries and electrostatic similarities. The best performance was achieved when logical selection was added. For the pose prediction, we utilized a similar consensus approach that amalgamated the results of the Glide-XP docking with structural knowledge and rescoring. The pose prediction results revealed that docking displayed reasonable performance in predicting the binding poses. However, prediction performance can be improved utilizing scientific experience and rescoring approaches. In both the virtual screening and pose prediction challenges, the top performance was achieved by our approaches. Here we describe the methods and strategies used in our approaches and discuss the rationale of their performances.

  19. Combining in silico and in cerebro approaches for virtual screening and pose prediction in SAMPL4.

    PubMed

    Voet, Arnout R D; Kumar, Ashutosh; Berenger, Francois; Zhang, Kam Y J

    2014-04-01

    The SAMPL challenges provide an ideal opportunity for unbiased evaluation and comparison of different approaches used in computational drug design. During the fourth round of this SAMPL challenge, we participated in the virtual screening and binding pose prediction on inhibitors targeting the HIV-1 integrase enzyme. For virtual screening, we used well known and widely used in silico methods combined with personal in cerebro insights and experience. Regular docking only performed slightly better than random selection, but the performance was significantly improved upon incorporation of additional filters based on pharmacophore queries and electrostatic similarities. The best performance was achieved when logical selection was added. For the pose prediction, we utilized a similar consensus approach that amalgamated the results of the Glide-XP docking with structural knowledge and rescoring. The pose prediction results revealed that docking displayed reasonable performance in predicting the binding poses. However, prediction performance can be improved utilizing scientific experience and rescoring approaches. In both the virtual screening and pose prediction challenges, the top performance was achieved by our approaches. Here we describe the methods and strategies used in our approaches and discuss the rationale of their performances.

  20. Combining Model-Based and Feature-Driven Diagnosis Approaches - A Case Study on Electromechanical Actuators

    NASA Technical Reports Server (NTRS)

    Narasimhan, Sriram; Roychoudhury, Indranil; Balaban, Edward; Saxena, Abhinav

    2010-01-01

    Model-based diagnosis typically uses analytical redundancy to compare predictions from a model against observations from the system being diagnosed. However this approach does not work very well when it is not feasible to create analytic relations describing all the observed data, e.g., for vibration data which is usually sampled at very high rates and requires very detailed finite element models to describe its behavior. In such cases, features (in time and frequency domains) that contain diagnostic information are extracted from the data. Since this is a computationally intensive process, it is not efficient to extract all the features all the time. In this paper we present an approach that combines the analytic model-based and feature-driven diagnosis approaches. The analytic approach is used to reduce the set of possible faults and then features are chosen to best distinguish among the remaining faults. We describe an implementation of this approach on the Flyable Electro-mechanical Actuator (FLEA) test bed.