DQE and system optimization for indirect-detection flat-panel imagers in diagnostic radiology

NASA Astrophysics Data System (ADS)

Siewerdsen, Jeffrey H.; Antonuk, Larry E.

1998-07-01

The performance of indirect-detection flat-panel imagers incorporating CsI:Tl x-ray converters is examined through calculation of the detective quantum efficiency (DQE) under conditions of chest radiography, fluoroscopy, and mammography. Calculations are based upon a cascaded systems model which has demonstrated excellent agreement with empirical signal, noise- power spectra, and DQE results. For each application, the DQE is calculated as a function of spatial-frequency and CsI:Tl thickness. A preliminary investigation into the optimization of flat-panel imaging systems is described, wherein the x-ray converter thickness which provides optimal DQE for a given imaging task is estimated. For each application, a number of example tasks involving detection of an object of variable size and contrast against a noisy background are considered. The method described is fairly general and can be extended to account for a variety of imaging tasks. For the specific examples considered, the preliminary results estimate optimal CsI:Tl thicknesses of approximately 450 micrometer (approximately 200 mg/cm2), approximately 320 micrometer (approximately 140 mg/cm2), and approximately 200 micrometer (approximately 90 mg/cm2) for chest radiography, fluoroscopy, and mammography, respectively. These results are expected to depend upon the imaging task as well as upon the quality of available CsI:Tl, and future improvements in scintillator fabrication could result in increased optimal thickness and DQE.

Preliminary investigation of power flow and electrode phenomena in a multi-megawatt coaxial plasma thruster

NASA Technical Reports Server (NTRS)

Schoenberg, Kurt; Gerwin, Richard; Henins, Ivars; Mayo, Robert; Scheuer, Jay; Nurden, Glen

1993-01-01

This paper summarizes preliminary experimental and theoretical research that was directed towards the study of quasisteady-state power flow in a large, un-optimized, multi-megawatt coaxial plasma thruster. The report addresses large coaxial thruster operation and includes evaluation and interpretation of the experimental results with a view to the development of efficient, steady-state megawatt-class magnetoplasmadynamic (MPD) thrusters.

Development of a multiple-parameter nonlinear perturbation procedure for transonic turbomachinery flows: Preliminary application to design/optimization problems

NASA Technical Reports Server (NTRS)

Stahara, S. S.; Elliott, J. P.; Spreiter, J. R.

1983-01-01

An investigation was conducted to continue the development of perturbation procedures and associated computational codes for rapidly determining approximations to nonlinear flow solutions, with the purpose of establishing a method for minimizing computational requirements associated with parametric design studies of transonic flows in turbomachines. The results reported here concern the extension of the previously developed successful method for single parameter perturbations to simultaneous multiple-parameter perturbations, and the preliminary application of the multiple-parameter procedure in combination with an optimization method to blade design/optimization problem. In order to provide as severe a test as possible of the method, attention is focused in particular on transonic flows which are highly supercritical. Flows past both isolated blades and compressor cascades, involving simultaneous changes in both flow and geometric parameters, are considered. Comparisons with the corresponding exact nonlinear solutions display remarkable accuracy and range of validity, in direct correspondence with previous results for single-parameter perturbations.

Multidisciplinary Design, Analysis, and Optimization Tool Development Using a Genetic Algorithm

NASA Technical Reports Server (NTRS)

Pak, Chan-gi; Li, Wesley

2009-01-01

Multidisciplinary design, analysis, and optimization using a genetic algorithm is being developed at the National Aeronautics and Space Administration Dryden Flight Research Center (Edwards, California) to automate analysis and design process by leveraging existing tools to enable true multidisciplinary optimization in the preliminary design stage of subsonic, transonic, supersonic, and hypersonic aircraft. This is a promising technology, but faces many challenges in large-scale, real-world application. This report describes current approaches, recent results, and challenges for multidisciplinary design, analysis, and optimization as demonstrated by experience with the Ikhana fire pod design.!

Preliminary Structural Design Using Topology Optimization with a Comparison of Results from Gradient and Genetic Algorithm Methods

NASA Technical Reports Server (NTRS)

Burt, Adam O.; Tinker, Michael L.

2014-01-01

In this paper, genetic algorithm based and gradient-based topology optimization is presented in application to a real hardware design problem. Preliminary design of a planetary lander mockup structure is accomplished using these methods that prove to provide major weight savings by addressing the structural efficiency during the design cycle. This paper presents two alternative formulations of the topology optimization problem. The first is the widely-used gradient-based implementation using commercially available algorithms. The second is formulated using genetic algorithms and internally developed capabilities. These two approaches are applied to a practical design problem for hardware that has been built, tested and proven to be functional. Both formulations converged on similar solutions and therefore were proven to be equally valid implementations of the process. This paper discusses both of these formulations at a high level.

Application of decomposition techniques to the preliminary design of a transport aircraft

NASA Technical Reports Server (NTRS)

Rogan, J. E.; Kolb, M. A.

1987-01-01

A nonlinear constrained optimization problem describing the preliminary design process for a transport aircraft has been formulated. A multifaceted decomposition of the optimization problem has been made. Flight dynamics, flexible aircraft loads and deformations, and preliminary structural design subproblems appear prominently in the decomposition. The use of design process decomposition for scheduling design projects, a new system integration approach to configuration control, and the application of object-centered programming to a new generation of design tools are discussed.

Design and Optimization of Composite Gyroscope Momentum Wheel Rings

NASA Technical Reports Server (NTRS)

Bednarcyk, Brett A.; Arnold, Steven M.

2007-01-01

Stress analysis and preliminary design/optimization procedures are presented for gyroscope momentum wheel rings composed of metallic, metal matrix composite, and polymer matrix composite materials. The design of these components involves simultaneously minimizing both true part volume and mass, while maximizing angular momentum. The stress analysis results are combined with an anisotropic failure criterion to formulate a new sizing procedure that provides considerable insight into the design of gyroscope momentum wheel ring components. Results compare the performance of two optimized metallic designs, an optimized SiC/Ti composite design, and an optimized graphite/epoxy composite design. The graphite/epoxy design appears to be far superior to the competitors considered unless a much greater premium is placed on volume efficiency compared to mass efficiency.

X-48B Preliminary Flight Test Results

NASA Technical Reports Server (NTRS)

Taylor, Brian R.

2009-01-01

This slide presentation reviews the preliminary Flight tests of the X-48B development program. The X-48B is a blended wing body aircraft that is being used to test various features of the BWB concept. The research concerns the following: (1) Turbofan Development, (2) Intelligent Flight Control and Optimization, (3) Airdata Calibration (4) Parameter Identification (i.e., Determination of the parameters of a mathematical model of a system based on observation of the system inputs and response.)

Brayton cycle heat exchanger and duct assembly (HXDA, preliminary design and technology tests

NASA Technical Reports Server (NTRS)

Coombs, M. G.; Morse, C. J.; Graves, R. F.; Gibson, J. C.

1972-01-01

A preliminary design of the heat exchanger and duct assembly (HXDA) for a 60 kwe, closed loop, Brayton cycle space power system is presented. This system is weight optimized within the constraints imposed by the defined structural and operational requirements. Also presented are the results of several small scale tests, directed to obtaining specific design data and/or the resolution of a design approach for long life Brayton cycle heat exchanger systems.

Multidisciplinary optimization of controlled space structures with global sensitivity equations

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; James, Benjamin B.; Graves, Philip C.; Woodard, Stanley E.

1991-01-01

A new method for the preliminary design of controlled space structures is presented. The method coordinates standard finite element structural analysis, multivariable controls, and nonlinear programming codes and allows simultaneous optimization of the structures and control systems of a spacecraft. Global sensitivity equations are a key feature of this method. The preliminary design of a generic geostationary platform is used to demonstrate the multidisciplinary optimization method. Fifteen design variables are used to optimize truss member sizes and feedback gain values. The goal is to reduce the total mass of the structure and the vibration control system while satisfying constraints on vibration decay rate. Incorporating the nonnegligible mass of actuators causes an essential coupling between structural design variables and control design variables. The solution of the demonstration problem is an important step toward a comprehensive preliminary design capability for structures and control systems. Use of global sensitivity equations helps solve optimization problems that have a large number of design variables and a high degree of coupling between disciplines.

Preliminary supersonic flight test evaluation of performance seeking control

NASA Technical Reports Server (NTRS)

Orme, John S.; Gilyard, Glenn B.

1993-01-01

Digital flight and engine control, powerful onboard computers, and sophisticated controls techniques may improve aircraft performance by maximizing fuel efficiency, maximizing thrust, and extending engine life. An adaptive performance seeking control system for optimizing the quasi-steady state performance of an F-15 aircraft was developed and flight tested. This system has three optimization modes: minimum fuel, maximum thrust, and minimum fan turbine inlet temperature. Tests of the minimum fuel and fan turbine inlet temperature modes were performed at a constant thrust. Supersonic single-engine flight tests of the three modes were conducted using varied after burning power settings. At supersonic conditions, the performance seeking control law optimizes the integrated airframe, inlet, and engine. At subsonic conditions, only the engine is optimized. Supersonic flight tests showed improvements in thrust of 9 percent, increases in fuel savings of 8 percent, and reductions of up to 85 deg R in turbine temperatures for all three modes. The supersonic performance seeking control structure is described and preliminary results of supersonic performance seeking control tests are given. These findings have implications for improving performance of civilian and military aircraft.

A dynamic multi-level optimal design method with embedded finite-element modeling for power transformers

NASA Astrophysics Data System (ADS)

Zhang, Yunpeng; Ho, Siu-lau; Fu, Weinong

2018-05-01

This paper proposes a dynamic multi-level optimal design method for power transformer design optimization (TDO) problems. A response surface generated by second-order polynomial regression analysis is updated dynamically by adding more design points, which are selected by Shifted Hammersley Method (SHM) and calculated by finite-element method (FEM). The updating stops when the accuracy requirement is satisfied, and optimized solutions of the preliminary design are derived simultaneously. The optimal design level is modulated through changing the level of error tolerance. Based on the response surface of the preliminary design, a refined optimal design is added using multi-objective genetic algorithm (MOGA). The effectiveness of the proposed optimal design method is validated through a classic three-phase power TDO problem.

Implementation of a Low-Thrust Trajectory Optimization Algorithm for Preliminary Design

NASA Technical Reports Server (NTRS)

Sims, Jon A.; Finlayson, Paul A.; Rinderle, Edward A.; Vavrina, Matthew A.; Kowalkowski, Theresa D.

2006-01-01

A tool developed for the preliminary design of low-thrust trajectories is described. The trajectory is discretized into segments and a nonlinear programming method is used for optimization. The tool is easy to use, has robust convergence, and can handle many intermediate encounters. In addition, the tool has a wide variety of features, including several options for objective function and different low-thrust propulsion models (e.g., solar electric propulsion, nuclear electric propulsion, and solar sail). High-thrust, impulsive trajectories can also be optimized.

Performance modeling of ultraviolet Raman lidar systems for daytime profiling of atmospheric water vapor

NASA Technical Reports Server (NTRS)

Ferrare, R. A.; Whiteman, D. N.; Melfi, S. H.; Goldsmith, J. E. M.; Bisson, S. E.; Lapp, M.

1991-01-01

We describe preliminary results from a comprehensive computer model developed to guide optimization of a Raman lidar system for measuring daytime profiles of atmospheric water vapor, emphasizing an ultraviolet, solar-blind approach.

Recent work and results on sparrow project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harvey, Neal R

2010-12-23

This briefing describes recent work undertaken on the Sparrow Project and results of this work. It describes experiments comparing the use of Genie with 2 classes with 3 classes for the problem of ship delineation. It also describes some preliminary work in the area of the optimization of segmentation techniques.

Preliminary Results from Small-Pixel CdZnTe and CdTe Arrays

NASA Technical Reports Server (NTRS)

Ramsey, B. D.; Sharma, D. P.; Meisner, J.; Austin, R. A.

1999-01-01

We have evaluated 2 small-pixel (0.75 mm) Cadmium-Zinc-Telluride arrays, and one Cadmium-Telluride array, all fabricated for MSFC by Metorex (Finland) and Baltic Science Institute (Riga, Latvia). Each array was optimized for operating temperature and collection bias. It was then exposed to Cadmium-109 and Iron-55 laboratory isotopes, to measure the energy resolution for each pixel and was then scanned with a finely-collimated x-ray beam, of width 50 micron, to examine pixel to pixel and inter-pixel charge collections efficiency. Preliminary results from these array tests will be presented.

Tissue welding with 980-nm diode laser system: preliminary study for determination of optimal parameters

NASA Astrophysics Data System (ADS)

Korkut, Zeynep D.; Tabakoglu, Haşim Ö.; Bozkulak, Özgüncem; Aksel, Ayla A.; Gulsoy, Murat

2006-02-01

In this study, tissue welding with 980-nm laser system, which is first-time in the literature, was performed. Hence, a preliminary study was done to determine optimal parameters for further studies. 1 cm long incisions done on the Wistar rat's dorsal skin were welded. Tissue welding with 980-nm wavelength depends on the degree of photothermal interaction. Thus, different power levels and exposure schedule were investigated. Dorsal sides of all animals were photographed from the date of surgery until they were sacrificed. The clinical examination - opening of wound and presence of infection - was noted. The rats did not show any abnormality on their health, behavior and nutrition manner. As a result, 980-nm diode laser was concluded to be a good candidate for tissue welding applications.

A Pharmacist-Physician Collaboration to Optimize Benzodiazepine Use for Anxiety and Sleep Symptom Control in Primary Care.

PubMed

Furbish, Shannon M L; Kroehl, Miranda E; Loeb, Danielle F; Lam, Huong Mindy; Lewis, Carmen L; Nelson, Jennifer; Chow, Zeta; Trinkley, Katy E

2017-08-01

Benzodiazepines are prescribed inappropriately in up to 40% of outpatients. The purpose of this study is to describe a collaborative team-based care model in which clinical pharmacists work with primary care providers (PCPs) to improve the safe use of benzodiazepines for anxiety and sleep disorders and to assess the preliminary results of the impact of the clinical service on patient outcomes. Adult patients were eligible if they received care from the academic primary care clinic, were prescribed a benzodiazepine chronically, and were not pregnant or managed by psychiatry. Outcomes included baseline PCP confidence and knowledge of appropriate benzodiazepine use, patient symptom severity, and medication changes. Twenty-five of 57 PCPs responded to the survey. PCPs reported greater confidence in diagnosing and treating generalized anxiety and panic disorders than sleep disorder and had variable knowledge of appropriate benzodiazepine prescribing. Twenty-nine patients had at least 1 visit. Over 44 total patient visits, 59% resulted in the addition or optimization of a nonbenzodiazepine medication and 46% resulted in the discontinuation or optimization of a benzodiazepine. Generalized anxiety symptom severity scores significantly improved (-2.0; 95% confidence interval (CI): -3.57 to -0.43). Collaborative team-based models that include clinical pharmacists in primary care can assist in optimizing high-risk benzodiazepine use. Although these findings suggest improvements in safe medication use and symptoms, additional studies are needed to confirm these preliminary results.

Tetrahedron Formation Control

NASA Technical Reports Server (NTRS)

Guzman, Jose J.

2003-01-01

Spacecraft flying in tetrahedron formations are excellent instrument platforms for electromagnetic and plasma studies. A minimum of four spacecraft - to establish a volume - is required to study some of the key regions of a planetary magnetic field. The usefulness of the measurements recorded is strongly affected by the tetrahedron orbital evolution. This paper considers the preliminary development of a general optimization procedure for tetrahedron formation control. The maneuvers are assumed to be impulsive and a multi-stage optimization method is employed. The stages include targeting to a fixed tetrahedron orientation, rotating and translating the tetrahedron and/or varying the initial and final times. The number of impulsive maneuvers citn also be varied. As the impulse locations and times change, new arcs are computed using a differential corrections scheme that varies the impulse magnitudes and directions. The result is a continuous trajectory with velocity discontinuities. The velocity discontinuities are then used to formulate the cost function. Direct optimization techniques are employed. The procedure is applied to the Magnetospheric Multiscale Mission (MMS) to compute preliminary formation control fuel requirements.

Irrational beliefs, optimism, pessimism, and psychological distress: a preliminary examination of differential effects in a college population.

PubMed

Chang, E C; Bridewell, W B

1998-02-01

The present study compared the effects of irrational beliefs measured by the Survey of Personal Beliefs (SPB) and optimism and pessimism as measured by the revised Life Orientation Test (LOT-R) on depressive and anxious symptoms 6 weeks later. Results of analysis of variances for both measures of psychological distress indicated a significant main effect for pessimism only. Implications for Ellis Rational Emotive Therapy are discussed.

Application of response surface techniques to helicopter rotor blade optimization procedure

NASA Technical Reports Server (NTRS)

Henderson, Joseph Lynn; Walsh, Joanne L.; Young, Katherine C.

1995-01-01

In multidisciplinary optimization problems, response surface techniques can be used to replace the complex analyses that define the objective function and/or constraints with simple functions, typically polynomials. In this work a response surface is applied to the design optimization of a helicopter rotor blade. In previous work, this problem has been formulated with a multilevel approach. Here, the response surface takes advantage of this decomposition and is used to replace the lower level, a structural optimization of the blade. Problems that were encountered and important considerations in applying the response surface are discussed. Preliminary results are also presented that illustrate the benefits of using the response surface.

Optimal non-linear health insurance.

PubMed

Blomqvist, A

1997-06-01

Most theoretical and empirical work on efficient health insurance has been based on models with linear insurance schedules (a constant co-insurance parameter). In this paper, dynamic optimization techniques are used to analyse the properties of optimal non-linear insurance schedules in a model similar to one originally considered by Spence and Zeckhauser (American Economic Review, 1971, 61, 380-387) and reminiscent of those that have been used in the literature on optimal income taxation. The results of a preliminary numerical example suggest that the welfare losses from the implicit subsidy to employer-financed health insurance under US tax law may be a good deal smaller than previously estimated using linear models.

RJMCMC based Text Placement to Optimize Label Placement and Quantity

NASA Astrophysics Data System (ADS)

Touya, Guillaume; Chassin, Thibaud

2018-05-01

Label placement is a tedious task in map design, and its automation has long been a goal for researchers in cartography, but also in computational geometry. Methods that search for an optimal or nearly optimal solution that satisfies a set of constraints, such as label overlapping, have been proposed in the literature. Most of these methods mainly focus on finding the optimal position for a given set of labels, but rarely allow the removal of labels as part of the optimization. This paper proposes to apply an optimization technique called Reversible-Jump Markov Chain Monte Carlo that enables to easily model the removal or addition during the optimization iterations. The method, quite preliminary for now, is tested on a real dataset, and the first results are encouraging.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beltran, C; Kamal, H

Purpose: To provide a multicriteria optimization algorithm for intensity modulated radiation therapy using pencil proton beam scanning. Methods: Intensity modulated radiation therapy using pencil proton beam scanning requires efficient optimization algorithms to overcome the uncertainties in the Bragg peaks locations. This work is focused on optimization algorithms that are based on Monte Carlo simulation of the treatment planning and use the weights and the dose volume histogram (DVH) control points to steer toward desired plans. The proton beam treatment planning process based on single objective optimization (representing a weighted sum of multiple objectives) usually leads to time-consuming iterations involving treatmentmore » planning team members. We proved a time efficient multicriteria optimization algorithm that is developed to run on NVIDIA GPU (Graphical Processing Units) cluster. The multicriteria optimization algorithm running time benefits from up-sampling of the CT voxel size of the calculations without loss of fidelity. Results: We will present preliminary results of Multicriteria optimization for intensity modulated proton therapy based on DVH control points. The results will show optimization results of a phantom case and a brain tumor case. Conclusion: The multicriteria optimization of the intensity modulated radiation therapy using pencil proton beam scanning provides a novel tool for treatment planning. Work support by a grant from Varian Inc.« less

WMOST v2 Case Study: Monponsett Ponds

EPA Science Inventory

This webinar presents an overview of the preliminary results of a case study application of EPA's Watershed Management Optimization Support Tool v2 (WMOST) for stakeholders in the Monponsett Ponds Watershed Workgroup. Monponsett Ponds is a large water system consisting of two ba...

Preliminary Design of Low-Thrust Interplanetary Missions

NASA Technical Reports Server (NTRS)

Sims, Jon A.; Flanagan, Steve N.

1997-01-01

For interplanetary missions, highly efficient electric propulsion systems can be used to increase the mass delivered to the destination and/or reduce the trip time over typical chemical propulsion systems. This technology is being demonstrated on the Deep Space 1 mission - part of NASA's New Millennium Program validating technologies which can lower the cost and risk and enhance the performance of future missions. With the successful demonstration on Deep Space 1, future missions can consider electric propulsion as a viable propulsion option. Electric propulsion systems, while highly efficient, produce only a small amount of thrust. As a result, the engines operate during a significant fraction of the trajectory. This characteristic makes it much more difficult to find optimal trajectories. The methods for optimizing low-thrust trajectories are typically categorized as either indirect, or direct. Indirect methods are based on calculus of variations, resulting in a two-point boundary value problem that is solved by satisfying terminal constraints and targeting conditions. These methods are subject to extreme sensitivity to the initial guess of the variables - some of which are not physically intuitive. Adding a gravity assist to the trajectory compounds the sensitivity. Direct methods parameterize the problem and use nonlinear programming techniques to optimize an objective function by adjusting a set of variables. A variety of methods of this type have been examined with varying results. These methods are subject to the limitations of the nonlinear programming techniques. In this paper we present a direct method intended to be used primarily for preliminary design of low-thrust interplanetary trajectories, including those with multiple gravity assists. Preliminary design implies a willingness to accept limited accuracy to achieve an efficient algorithm that executes quickly.

Optimized Extraction, Preliminary Characterization, and In Vitro Antioxidant Activity of Polysaccharides from Glycyrrhiza Uralensis Fisch

PubMed Central

Chen, Jie; Li, Wan-chen; Gu, Xin-li

2017-01-01

Background This study performed optimized extraction, preliminary characterization, and in vitro antioxidant activities of polysaccharides from Glycyrrhiza uralensis Fisch. Material/Methods Three parameters (extraction temperature, ratio of water to raw material, and extraction time) were optimized for yields of G. uralensis polysaccharides (GUP) using response surface methodology with Box-Behnken design (BBD). The GUP was purified using DEAE cellulose 32-column chromatography. The main fraction obtained from G. uralensis Fisch was GUP-II, which was composed of rhamnose, arabinose, galactose, and glucose monosaccharide, was screened for antioxidant properties using DP Hand hydroxyl radical scavenging assays. In addition, immunological activity of GUP-II was determined by nitric oxide and lymphocyte proliferation assays. Results Optimization revealed maximum GUP yields with an extraction temperature of 99°C, water: raw material ratio of 15: 1, and extraction duration of 2 h. GUP-II purified from G. uralensis Fisch had good in vitro DPPH and hydroxyl radical scavenging abilities. Immunologically, GUP-II significantly stimulated NO production in RAW 264.7 macrophages, and significantly enhanced LPS-induced lymphocyte proliferation. Conclusions Extraction of GUP from G. uralensis Fisch can be optimized with respect to temperature, extraction period, and ratio of water to material, using response surface methodology. The purified product (GUP-II) possesses excellent antioxidant and immunological activities. PMID:28404983

X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization

PubMed Central

Schieferstein, Jeremy M.; Pawate, Ashtamurthy S.; Wan, Frank; Sheraden, Paige N.; Broecker, Jana; Ernst, Oliver P.; Gennis, Robert B.

2017-01-01

Elucidating and clarifying the function of membrane proteins ultimately requires atomic resolution structures as determined most commonly by X-ray crystallography. Many high impact membrane protein structures have resulted from advanced techniques such as in meso crystallization that present technical difficulties for the set-up and scale-out of high-throughput crystallization experiments. In prior work, we designed a novel, low-throughput X-ray transparent microfluidic device that automated the mixing of protein and lipid by diffusion for in meso crystallization trials. Here, we report X-ray transparent microfluidic devices for high-throughput crystallization screening and optimization that overcome the limitations of scale and demonstrate their application to the crystallization of several membrane proteins. Two complementary chips are presented: (1) a high-throughput screening chip to test 192 crystallization conditions in parallel using as little as 8 nl of membrane protein per well and (2) a crystallization optimization chip to rapidly optimize preliminary crystallization hits through fine-gradient re-screening. We screened three membrane proteins for new in meso crystallization conditions, identifying several preliminary hits that we tested for X-ray diffraction quality. Further, we identified and optimized the crystallization condition for a photosynthetic reaction center mutant and solved its structure to a resolution of 3.5 Å. PMID:28469762

Methods of Combinatorial Optimization to Reveal Factors Affecting Gene Length

PubMed Central

Bolshoy, Alexander; Tatarinova, Tatiana

2012-01-01

In this paper we present a novel method for genome ranking according to gene lengths. The main outcomes described in this paper are the following: the formulation of the genome ranking problem, presentation of relevant approaches to solve it, and the demonstration of preliminary results from prokaryotic genomes ordering. Using a subset of prokaryotic genomes, we attempted to uncover factors affecting gene length. We have demonstrated that hyperthermophilic species have shorter genes as compared with mesophilic organisms, which probably means that environmental factors affect gene length. Moreover, these preliminary results show that environmental factors group together in ranking evolutionary distant species. PMID:23300345

Phase 1 of the near team hybrid passenger vehicle development program. Appendix C: Preliminary design data package, volume 1

NASA Technical Reports Server (NTRS)

Piccolo, R.

1979-01-01

The methodology used for vehicle layout and component definition is described as well as techniques for system optimization and energy evaluation. The preliminary design is examined with particular attention given to body and structure; propulsion system; crash analysis and handling; internal combustion engine; DC motor separately excited; Ni-Zn battery; transmission; control system; vehicle auxiliarries; weight breakdown, and life cycle costs. Formulas are given for the quantification of energy consumption and results are compared with the reference vehicle.

Lyapunov optimal feedback control of a nonlinear inverted pendulum

NASA Technical Reports Server (NTRS)

Grantham, W. J.; Anderson, M. J.

1989-01-01

Liapunov optimal feedback control is applied to a nonlinear inverted pendulum in which the control torque was constrained to be less than the nonlinear gravity torque in the model. This necessitates a control algorithm which 'rocks' the pendulum out of its potential wells, in order to stabilize it at a unique vertical position. Simulation results indicate that a preliminary Liapunov feedback controller can successfully overcome the nonlinearity and bring almost all trajectories to the target.

Capability of microalgae for local saline sewage treatment towards biodiesel production

NASA Astrophysics Data System (ADS)

Wu, K.-C.; Yau, Y.-H.; Ho, K.-C.

2017-08-01

Seawater flushing was introduced in Hong Kong since 1950’s. High salinity has an inhibitory effect on nitrification and biological phosphorus uptake of microorganisms. Therefore, saline sewage has impact on traditional biological wastewater treatment. Saline conditions of domestic wastewater then pose opportunity to use algal technology in wastewater treatment. During the treatment (phycoremediation), biodiesel can be produced. This study aims to give an in-depth investigation and development on application of local microalgal strains on biodiesel production. Dunaliella tertiolecta was selected the appropriate algal species with high potential for phycoremediation then biodiesel production. D.tertiolecta was further investigated by optimizing its growth in different process condition in preliminary effluent as based medium. The optimized process condition were acclimated culture with medium initial cell number (5.0 ×105 cells mL-1), under 5% CO2 aerations in preliminary effluent adjust to 15 psu (denoting practical salinity unit). Results showed that lipid content increased from 30.2% to 42%, and biomass productivity reached 463.3 mg L-1day-1 by Fatty acid Methyl Ester (FAME) profile was found for biodiesel production in optimized stage. The treatment period of preliminary effluent was shortened from 15d in original design (unacclimated culture, low initial cell number (5.0 ×105 cells mL-1), without CO2 aeration) to 4d.

CORSS: Cylinder Optimization of Rings, Skin, and Stringers

NASA Technical Reports Server (NTRS)

Finckenor, J.; Rogers, P.; Otte, N.

1994-01-01

Launch vehicle designs typically make extensive use of cylindrical skin stringer construction. Structural analysis methods are well developed for preliminary design of this type of construction. This report describes an automated, iterative method to obtain a minimum weight preliminary design. Structural optimization has been researched extensively, and various programs have been written for this purpose. Their complexity and ease of use depends on their generality, the failure modes considered, the methodology used, and the rigor of the analysis performed. This computer program employs closed-form solutions from a variety of well-known structural analysis references and joins them with a commercially available numerical optimizer called the 'Design Optimization Tool' (DOT). Any ring and stringer stiffened shell structure of isotropic materials that has beam type loading can be analyzed. Plasticity effects are not included. It performs a more limited analysis than programs such as PANDA, but it provides an easy and useful preliminary design tool for a large class of structures. This report briefly describes the optimization theory, outlines the development and use of the program, and describes the analysis techniques that are used. Examples of program input and output, as well as the listing of the analysis routines, are included.

Evolutionary Optimization of Yagi-Uda Antennas

NASA Technical Reports Server (NTRS)

Lohn, Jason D.; Kraus, William F.; Linden, Derek S.; Colombano, Silvano P.

2001-01-01

Yagi-Uda antennas are known to be difficult to design and optimize due to their sensitivity at high gain, and the inclusion of numerous parasitic elements. We present a genetic algorithm-based automated antenna optimization system that uses a fixed Yagi-Uda topology and a byte-encoded antenna representation. The fitness calculation allows the implicit relationship between power gain and sidelobe/backlobe loss to emerge naturally, a technique that is less complex than previous approaches. The genetic operators used are also simpler. Our results include Yagi-Uda antennas that have excellent bandwidth and gain properties with very good impedance characteristics. Results exceeded previous Yagi-Uda antennas produced via evolutionary algorithms by at least 7.8% in mainlobe gain. We also present encouraging preliminary results where a coevolutionary genetic algorithm is used.

PROCESS ENGINEERING TO OPTIMIZE BIOSAND FILTRATION FOR POINT-OF-USE APPLICATIONS IN THE DEVELOPING WORLD

EPA Science Inventory

We anticipate that future laboratory results will verify our preliminary findings that the BSF is capable of removing approximately 99% of enteric bacteria and roughly 90% of enteric viruses as currently configured. We hope that by understanding the operating conditions and me...

Space Shuttle propulsion parameter estimation using optimal estimation techniques

NASA Technical Reports Server (NTRS)

1983-01-01

The fifth monthly progress report includes corrections and additions to the previously submitted reports. The addition of the SRB propellant thickness as a state variable is included with the associated partial derivatives. During this reporting period, preliminary results of the estimation program checkout was presented to NASA technical personnel.

Optimization of interplanetary trajectories with unpowered planetary swingbys

NASA Technical Reports Server (NTRS)

Sauer, Carl G., Jr.

1988-01-01

A method is presented for calculating and optimizing unpowered planetary swingby trajectories using a patched conic trajectory generator. Examples of unpowered swingby trajectories are given to demonstrate the method. The method, which uses primer vector theory, is not highly accurate, but provides projections for preliminary mission definition studies. Advantages to using a patched conic trajectory simulation for preliminary studies which examine many different and complex missions include calculation speed and adaptability to changes or additions to the formulation.

Preliminary experimental results from a MARS Micro-CT system.

PubMed

He, Peng; Yu, Hengyong; Thayer, Patrick; Jin, Xin; Xu, Qiong; Bennett, James; Tappenden, Rachael; Wei, Biao; Goldstein, Aaron; Renaud, Peter; Butler, Anthony; Butler, Phillip; Wang, Ge

2012-01-01

The Medipix All Resolution System (MARS) system is a commercial spectral/multi-energy micro-CT scanner designed and assembled by the MARS Bioimaging, Ltd. in New Zealand. This system utilizes the state-of-the-art Medipix photon-counting, energy-discriminating detector technology developed by a collaboration at European Organization for Nuclear Research (CERN). In this paper, we report our preliminary experimental results using this system, including geometrical alignment, photon energy characterization, protocol optimization, and spectral image reconstruction. We produced our scan datasets with a multi-material phantom, and then applied ordered subset-simultaneous algebraic reconstruction technique (OS-SART) to reconstruct images in different energy ranges and principal component analysis (PCA) to evaluate spectral deviation among the energy ranges.

Designing a freeform optic for oblique illumination

NASA Astrophysics Data System (ADS)

Uthoff, Ross D.; Ulanch, Rachel N.; Williams, Kaitlyn E.; Ruiz Diaz, Liliana; King, Page; Koshel, R. John

2017-11-01

The Functional Freeform Fitting (F4) method is utilized to design a freeform optic for oblique illumination of Mark Rothko's Green on Blue (1956). Shown are preliminary results from an iterative freeform design process; from problem definition and specification development to surface fit, ray tracing results, and optimization. This method is applicable to both point and extended sources of various geometries.

Development of a turbomachinery design optimization procedure using a multiple-parameter nonlinear perturbation method

NASA Technical Reports Server (NTRS)

Stahara, S. S.

1984-01-01

An investigation was carried out to complete the preliminary development of a combined perturbation/optimization procedure and associated computational code for designing optimized blade-to-blade profiles of turbomachinery blades. The overall purpose of the procedures developed is to provide demonstration of a rapid nonlinear perturbation method for minimizing the computational requirements associated with parametric design studies of turbomachinery flows. The method combines the multiple parameter nonlinear perturbation method, successfully developed in previous phases of this study, with the NASA TSONIC blade-to-blade turbomachinery flow solver, and the COPES-CONMIN optimization procedure into a user's code for designing optimized blade-to-blade surface profiles of turbomachinery blades. Results of several design applications and a documented version of the code together with a user's manual are provided.

Preliminary design of 1 kW bipolar Ni-MH battery for LEO-satellite application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, J.H.; Reisner, D.E.; Klein, M.G.

1996-12-31

Electro Energy, Inc. (EEI) is developing a bipolar nickel-metal hydride rechargeable battery based upon the use of stackable wafer cells. The key to viable bipolar operation has been this unique modular (unitized) approach. The patented unit wafer-cell construct exploits the chemical and thermal properties of a proprietary electrically conductive plastic film. Characteristic of bipolar batteries, current flows across the cell interfaces-perpendicular to the electrode plane. EEI has recently contracted with NASA Lewis Research Center (LeRC) to develop an optimized design 1 kW flightweight battery, for low-earth-orbit (LEO) satellite applications, over a 4-year period with a deliverable flightweight design package. Themore » contract includes an option for EEI to deliver up to three flight quality batteries in an 18-month follow-on program. NASA LeRC has promulgated that the program steps include the design, fabrication, and evaluation of four evolutionary stages of the final battery design which have been designated Preliminary, Improved, Optimized, and Flightweight Design. Initial results from the Preliminary Stage are presented including a 1 kW battery design, thermal design, parameter study, and component development in subscale bipolar batteries.« less

Options for Robust Airfoil Optimization under Uncertainty

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; Li, Wu

2002-01-01

A robust optimization method is developed to overcome point-optimization at the sampled design points. This method combines the best features from several preliminary methods proposed by the authors and their colleagues. The robust airfoil shape optimization is a direct method for drag reduction over a given range of operating conditions and has three advantages: (1) it prevents severe degradation in the off-design performance by using a smart descent direction in each optimization iteration, (2) it uses a large number of spline control points as design variables yet the resulting airfoil shape does not need to be smoothed, and (3) it allows the user to make a tradeoff between the level of optimization and the amount of computing time consumed. For illustration purposes, the robust optimization method is used to solve a lift-constrained drag minimization problem for a two-dimensional (2-D) airfoil in Euler flow with 20 geometric design variables.

An Optimization Framework for Dynamic Hybrid Energy Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wenbo Du; Humberto E Garcia; Christiaan J.J. Paredis

A computational framework for the efficient analysis and optimization of dynamic hybrid energy systems (HES) is developed. A microgrid system with multiple inputs and multiple outputs (MIMO) is modeled using the Modelica language in the Dymola environment. The optimization loop is implemented in MATLAB, with the FMI Toolbox serving as the interface between the computational platforms. Two characteristic optimization problems are selected to demonstrate the methodology and gain insight into the system performance. The first is an unconstrained optimization problem that optimizes the dynamic properties of the battery, reactor and generator to minimize variability in the HES. The second problemmore » takes operating and capital costs into consideration by imposing linear and nonlinear constraints on the design variables. The preliminary optimization results obtained in this study provide an essential step towards the development of a comprehensive framework for designing HES.« less

Preliminary investigation of power flow and electrode phenomena in a multi-megawatt coaxial plasma thruster

NASA Technical Reports Server (NTRS)

Schoenberg, Kurt F.; Gerwin, Richard A.; Henins, Ivars; Mayo, Robert; Scheuer, Jay; Wurden, Glen

1992-01-01

The present report on preliminary results of theoretical and experimental investigations of power flow in a large, unoptimized, multimegawatt coaxial thruster evaluates the significance of these data for the development of efficient, megawatt-class magnetoplasmadynamic (MPD) thrusters. The good agreement obtained between thruster operational performance and model predictions suggests that ideal MHD processes, including those of a magnetic nozzle, play an important role in coaxial plasma thruster dynamics at power levels relevant to advanced space propulsion. An optimized magnetic nozzle design would aid the development of efficient, multimegawatt MPD thrusters.

Neuronal Tracing with Magnetic Labels: NMR Imaging Methods, Preliminary Results, and New Optimized Coils.

NASA Astrophysics Data System (ADS)

Ghosh, Pratik

1992-01-01

The investigations focussed on in vivo NMR imaging studies of magnetic particles with and within neural cells. NMR imaging methods, both Fourier transform and projection reconstruction, were implemented and new protocols were developed to perform "Neuronal Tracing with Magnetic Labels" on small animal brains. Having performed the preliminary experiments with neuronal tracing, new optimized coils and experimental set-up were devised. A novel gradient coil technology along with new rf-coils were implemented, and optimized for future use with small animals in them. A new magnetic labelling procedure was developed that allowed labelling of billions of cells with ultra -small magnetite particles in a short time. The relationships among the viability of such cells, the amount of label and the contrast in the images were studied as quantitatively as possible. Intracerebral grafting of magnetite labelled fetal rat brain cells made it possible for the first time to attempt monitoring in vivo the survival, differentiation, and possible migration of both host and grafted cells in the host rat brain. This constituted the early steps toward future experiments that may lead to the monitoring of human brain grafts of fetal brain cells. Preliminary experiments with direct injection of horse radish peroxidase-conjugated magnetite particles into neurons, followed by NMR imaging, revealed a possible non-invasive alternative, allowing serial study of the dynamic transport pattern of tracers in single living animals. New gradient coils were built by using parallel solid-conductor ribbon cables that could be wrapped easily and quickly. Rapid rise times provided by these coils allowed implementation of fast imaging methods. Optimized rf-coil circuit development made it possible to understand better the sample-coil properties and the associated trade -offs in cases of small but conducting samples.

Dual-fuel, dual-throat engine preliminary analysis

NASA Technical Reports Server (NTRS)

Obrien, C. J.

1979-01-01

A propulsion system analysis of the dual fuel, dual throat engine for launch vehicle applications was conducted. Basic dual throat engine characterization data were obtained to allow vehicle optimization studies to be conducted. A preliminary baseline engine system was defined.

Efficient Simulation Budget Allocation for Selecting an Optimal Subset

NASA Technical Reports Server (NTRS)

Chen, Chun-Hung; He, Donghai; Fu, Michael; Lee, Loo Hay

2008-01-01

We consider a class of the subset selection problem in ranking and selection. The objective is to identify the top m out of k designs based on simulated output. Traditional procedures are conservative and inefficient. Using the optimal computing budget allocation framework, we formulate the problem as that of maximizing the probability of correc tly selecting all of the top-m designs subject to a constraint on the total number of samples available. For an approximation of this corre ct selection probability, we derive an asymptotically optimal allocat ion and propose an easy-to-implement heuristic sequential allocation procedure. Numerical experiments indicate that the resulting allocatio ns are superior to other methods in the literature that we tested, and the relative efficiency increases for larger problems. In addition, preliminary numerical results indicate that the proposed new procedur e has the potential to enhance computational efficiency for simulation optimization.

OPDOT: A computer program for the optimum preliminary design of a transport airplane

NASA Technical Reports Server (NTRS)

Sliwa, S. M.; Arbuckle, P. D.

1980-01-01

A description of a computer program, OPDOT, for the optimal preliminary design of transport aircraft is given. OPDOT utilizes constrained parameter optimization to minimize a performance index (e.g., direct operating cost per block hour) while satisfying operating constraints. The approach in OPDOT uses geometric descriptors as independent design variables. The independent design variables are systematically iterated to find the optimum design. The technical development of the program is provided and a program listing with sample input and output are utilized to illustrate its use in preliminary design. It is not meant to be a user's guide, but rather a description of a useful design tool developed for studying the application of new technologies to transport airplanes.

Stochastic Methods for Aircraft Design

NASA Technical Reports Server (NTRS)

Pelz, Richard B.; Ogot, Madara

1998-01-01

The global stochastic optimization method, simulated annealing (SA), was adapted and applied to various problems in aircraft design. The research was aimed at overcoming the problem of finding an optimal design in a space with multiple minima and roughness ubiquitous to numerically generated nonlinear objective functions. SA was modified to reduce the number of objective function evaluations for an optimal design, historically the main criticism of stochastic methods. SA was applied to many CFD/MDO problems including: low sonic-boom bodies, minimum drag on supersonic fore-bodies, minimum drag on supersonic aeroelastic fore-bodies, minimum drag on HSCT aeroelastic wings, FLOPS preliminary design code, another preliminary aircraft design study with vortex lattice aerodynamics, HSR complete aircraft aerodynamics. In every case, SA provided a simple, robust and reliable optimization method which found optimal designs in order 100 objective function evaluations. Perhaps most importantly, from this academic/industrial project, technology has been successfully transferred; this method is the method of choice for optimization problems at Northrop Grumman.

Algorithm for optimizing bipolar interconnection weights with applications in associative memories and multitarget classification.

PubMed

Chang, S; Wong, K W; Zhang, W; Zhang, Y

1999-08-10

An algorithm for optimizing a bipolar interconnection weight matrix with the Hopfield network is proposed. The effectiveness of this algorithm is demonstrated by computer simulation and optical implementation. In the optical implementation of the neural network the interconnection weights are biased to yield a nonnegative weight matrix. Moreover, a threshold subchannel is added so that the system can realize, in real time, the bipolar weighted summation in a single channel. Preliminary experimental results obtained from the applications in associative memories and multitarget classification with rotation invariance are shown.

Algorithm for Optimizing Bipolar Interconnection Weights with Applications in Associative Memories and Multitarget Classification

NASA Astrophysics Data System (ADS)

Chang, Shengjiang; Wong, Kwok-Wo; Zhang, Wenwei; Zhang, Yanxin

1999-08-01

An algorithm for optimizing a bipolar interconnection weight matrix with the Hopfield network is proposed. The effectiveness of this algorithm is demonstrated by computer simulation and optical implementation. In the optical implementation of the neural network the interconnection weights are biased to yield a nonnegative weight matrix. Moreover, a threshold subchannel is added so that the system can realize, in real time, the bipolar weighted summation in a single channel. Preliminary experimental results obtained from the applications in associative memories and multitarget classification with rotation invariance are shown.

Optimization process planning using hybrid genetic algorithm and intelligent search for job shop machining.

PubMed

Salehi, Mojtaba; Bahreininejad, Ardeshir

2011-08-01

Optimization of process planning is considered as the key technology for computer-aided process planning which is a rather complex and difficult procedure. A good process plan of a part is built up based on two elements: (1) the optimized sequence of the operations of the part; and (2) the optimized selection of the machine, cutting tool and Tool Access Direction (TAD) for each operation. In the present work, the process planning is divided into preliminary planning, and secondary/detailed planning. In the preliminary stage, based on the analysis of order and clustering constraints as a compulsive constraint aggregation in operation sequencing and using an intelligent searching strategy, the feasible sequences are generated. Then, in the detailed planning stage, using the genetic algorithm which prunes the initial feasible sequences, the optimized operation sequence and the optimized selection of the machine, cutting tool and TAD for each operation based on optimization constraints as an additive constraint aggregation are obtained. The main contribution of this work is the optimization of sequence of the operations of the part, and optimization of machine selection, cutting tool and TAD for each operation using the intelligent search and genetic algorithm simultaneously.

Optimization process planning using hybrid genetic algorithm and intelligent search for job shop machining

PubMed Central

Salehi, Mojtaba

2010-01-01

Optimization of process planning is considered as the key technology for computer-aided process planning which is a rather complex and difficult procedure. A good process plan of a part is built up based on two elements: (1) the optimized sequence of the operations of the part; and (2) the optimized selection of the machine, cutting tool and Tool Access Direction (TAD) for each operation. In the present work, the process planning is divided into preliminary planning, and secondary/detailed planning. In the preliminary stage, based on the analysis of order and clustering constraints as a compulsive constraint aggregation in operation sequencing and using an intelligent searching strategy, the feasible sequences are generated. Then, in the detailed planning stage, using the genetic algorithm which prunes the initial feasible sequences, the optimized operation sequence and the optimized selection of the machine, cutting tool and TAD for each operation based on optimization constraints as an additive constraint aggregation are obtained. The main contribution of this work is the optimization of sequence of the operations of the part, and optimization of machine selection, cutting tool and TAD for each operation using the intelligent search and genetic algorithm simultaneously. PMID:21845020

Initial operation of high power ICRF system for long pulse in EAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qin, C. M., E-mail: chmq@ipp.ac.cn; Zhao, Y. P.; Zhang, X. J.

2015-12-10

The ICRF heating system on EAST upgraded by active cooling aims for long pulse operation. In this paper, the main technical features of the ICRF system are described. One of a major challenges for long pulse operation is RF-edge interactions induced impurity production and heat loading. In EAST, ICRF antenna protections and Faraday screen bars damaged due to LH electron beam are found. Preliminary results for the analysis of the interaction between LHCD and ICRF antenna are discussed. Increase of metal impurities in the plasma during RF pulse and in a larger core radiation are also shown. These RF-edge interactionsmore » at EAST and some preliminary results for the optimizing RF performance will be presented.« less

Assessing Self-Efficacy Beliefs and Academic Outcomes: The Case for Specificity and Correspondence.

ERIC Educational Resources Information Center

Pajares, Frank

Guidelines regarding self-efficacy assessment are highlighted in the first section of this paper. In the second section, the issue of specificity versus generality of measurement is clarified. And last, preliminary results of a study of eighth graders (n=172) are presented which demonstrate that: (1) the optimal level of specificity of any…

Preliminary analysis of EUSO—TA data

NASA Astrophysics Data System (ADS)

Fenu, F.; Piotrowski, L. W.; Shin, H.; Jung, A.; Bacholle, S.; Bisconti, F.; Capel, F.; Eser, J.; Kawasaki, Y.; Kuznetsov, E.; Larsson, O.; Mackovjak, S.; Miyamoto, H.; Plebaniak, Z.; Prevot, G.; Putis, M.; Shinozaki, K.; Adams, J.; Bertaina, M.; Bobik, P.; Casolino, M.; Matthews, J. N.; Ricci, M.; Wiencke, L.; EUSO-TA Collaboration

2016-05-01

The EUSO-TA detector is a pathfinder for the JEM-EUSO project and is currently installed in Black Rock Mesa (Utah) on the site of the Telescope Array fluorescence detectors. Aim of this experiment is to validate the observation principle of JEM-EUSO on air showers measured from ground. The experiment gets data in coincidence with the TA triggers to increase the likelihood of cosmic ray detection. In this framework the collaboration is also testing the detector response with respect to several test events from lasers and LED flashers. Moreover, another aim of the project is the validation of the stability of the data acquisition chain in real sky condition and the optimization of the trigger scheme for the rejection of background. Data analysis is ongoing to identify cosmic ray events in coincidence with the TA detector. In this contribution we will show the response of the EUSO-TA detector to all the different typologies of events and we will show some preliminary results on the trigger optimization performed on such data.

Preliminary Sizing Study of Ares-I and Ares-V Liquid Hydrogen Tanks

NASA Technical Reports Server (NTRS)

Oliver, Stanley T.; Harper, David W.

2012-01-01

A preliminary sizing study of two cryogenic propellant tanks was performed using a FORTRAN optimization program to determine weight efficient orthogrid designs for the tank barrels sections only. Various tensile and compressive failure modes were considered, including general buckling of cylinders with a shell buckling knockdown factor. Eight independent combinations of three design requirements were also considered and their effects on the tanks weight. The approach was to investigate each design case with a variable shell buckling knockdown factor, determining the most weight efficient combination of orthogrid design parameters. Numerous optimization analyses were performed, and the results presented herein compare the effects of the different design requirements and shell buckling knockdown factor. Through a series of comparisons between design requirements or shell buckling knockdown factors, the relative change in overall tank barrel weights is shown. The findings indicate that the design requirements can substantually increase the tank weight while a less conservative shell buckling knockdown factor can modestly reduce the tank weight.

Looking for new biomarkers of skin wound vitality with a cytokine-based multiplex assay: preliminary study.

PubMed

Peyron, Pierre-Antoine; Baccino, Éric; Nagot, Nicolas; Lehmann, Sylvain; Delaby, Constance

2017-02-01

Determination of skin wound vitality is an important issue in forensic practice. No reliable biomarker currently exists. Quantification of inflammatory cytokines in injured skin with MSD ® technology is an innovative and promising approach. This preliminary study aims to develop a protocol for the preparation and the analysis of skin samples. Samples from ante mortem wounds, post mortem wounds, and intact skin ("control samples") were taken from corpses at the autopsy. After an optimization of the pre-analytical protocol had been performed in terms of skin homogeneisation and proteic extraction, the concentration of TNF-α was measured in each sample with the MSD ® approach. Then five other cytokines of interest (IL-1β, IL-6, IL-10, IL-12p70 and IFN-γ) were simultaneously quantified with a MSD ® multiplex assay. The optimal pre-analytical conditions consist in a proteic extraction from a 6 mm diameter skin sample, in a PBS buffer with triton 0,05%. Our results show the linearity and the reproductibility of the TNF-α quantification with MSD ® , and an inter- and intra-individual variability of the concentrations of proteins. The MSD ® multiplex assay is likely to detect differential skin concentrations for each cytokine of interest. This preliminary study was used to develop and optimize the pre-analytical and analytical conditions of the MSD ® method using injured and healthy skin samples, for the purpose of looking for and identifying the cytokine, or the set of cytokines, that may be biomarkers of skin wound vitality.

The optimization of the inverted occulter of the solar orbiter/METIS coronagraph/spectrometer

NASA Astrophysics Data System (ADS)

Landini, F.; Vives, S.; Romoli, M.; Guillon, C.; Pancrazzi, M.; Escolle, C.; Focardi, M.; Fineschi, S.; Antonucci, E.; Nicolini, G.; Naletto, G.; Nicolosi, P.; Spadaro, D.

2017-11-01

The coronagraph/spectrometer METIS (Multi Element Telescope for Imaging and Spectroscopy), selected to fly aboard the Solar Orbiter ESA/NASA mission, is conceived to perform imaging (in visible, UV and EUV) and spectroscopy (in EUV) of the solar corona. It is an integrated instrument suite located on a single optical bench and sharing a unique aperture on the satellite heat shield. As every coronagraph, METIS is highly demanding in terms of stray light suppression. In order to meet the strict thermal requirements of Solar Orbiter, METIS optical design has been optimized by moving the entrance pupil at the level of the external occulter on the S/C thermal shield, thus reducing the size of the external aperture. The scheme is based on an inverted external-occulter (IEO). The IEO consists of a circular aperture on the Solar Orbiter thermal shield. A spherical mirror rejects back the disk-light through the IEO. The experience built on all the previous space coronagraphs forces designers to dedicate a particular attention to the occulter optimization. Two breadboards were manufactured to perform occulter optimization measurements: BOA (Breadboard of the Occulting Assembly) and ANACONDA (AN Alternative COnfiguration for the Occulting Native Design Assembly). A preliminary measurement campaign has been carried on at the Laboratoire d'Astrophysique de Marseille. In this paper we describe BOA and ANACONDA designs, the laboratory set-up and the preliminary results.

Towards the novel reasoning among particles in PSO by the use of RDF and SPARQL.

PubMed

Fister, Iztok; Yang, Xin-She; Ljubič, Karin; Fister, Dušan; Brest, Janez; Fister, Iztok

2014-01-01

The significant development of the Internet has posed some new challenges and many new programming tools have been developed to address such challenges. Today, semantic web is a modern paradigm for representing and accessing knowledge data on the Internet. This paper tries to use the semantic tools such as resource definition framework (RDF) and RDF query language (SPARQL) for the optimization purpose. These tools are combined with particle swarm optimization (PSO) and the selection of the best solutions depends on its fitness. Instead of the local best solution, a neighborhood of solutions for each particle can be defined and used for the calculation of the new position, based on the key ideas from semantic web domain. The preliminary results by optimizing ten benchmark functions showed the promising results and thus this method should be investigated further.

Optimization of the imaging response of scanning microwave microscopy measurements

NASA Astrophysics Data System (ADS)

Sardi, G. M.; Lucibello, A.; Kasper, M.; Gramse, G.; Proietti, E.; Kienberger, F.; Marcelli, R.

2015-07-01

In this work, we present the analytical modeling and preliminary experimental results for the choice of the optimal frequencies when performing amplitude and phase measurements with a scanning microwave microscope. In particular, the analysis is related to the reflection mode operation of the instrument, i.e., the acquisition of the complex reflection coefficient data, usually referred as S11. The studied configuration is composed of an atomic force microscope with a microwave matched nanometric cantilever probe tip, connected by a λ/2 coaxial cable resonator to a vector network analyzer. The set-up is provided by Keysight Technologies. As a peculiar result, the optimal frequencies, where the maximum sensitivity is achieved, are different for the amplitude and for the phase signals. The analysis is focused on measurements of dielectric samples, like semiconductor devices, textile pieces, and biological specimens.

Multidisciplinary optimization of a controlled space structure using 150 design variables

NASA Technical Reports Server (NTRS)

James, Benjamin B.

1993-01-01

A controls-structures interaction design method is presented. The method coordinates standard finite-element structural analysis, multivariable controls, and nonlinear programming codes and allows simultaneous optimization of the structure and control system of a spacecraft. Global sensitivity equations are used to account for coupling between the disciplines. Use of global sensitivity equations helps solve optimization problems that have a large number of design variables and a high degree of coupling between disciplines. The preliminary design of a generic geostationary platform is used to demonstrate the multidisciplinary optimization method. Design problems using 15, 63, and 150 design variables to optimize truss member sizes and feedback gain values are solved and the results are presented. The goal is to reduce the total mass of the structure and the vibration control system while satisfying constraints on vibration decay rate. Incorporation of the nonnegligible mass of actuators causes an essential coupling between structural design variables and control design variables.

Optimal combining of ground-based sensors for the purpose of validating satellite-based rainfall estimates

NASA Technical Reports Server (NTRS)

Krajewski, Witold F.; Rexroth, David T.; Kiriaki, Kiriakie

1991-01-01

Two problems related to radar rainfall estimation are described. The first part is a description of a preliminary data analysis for the purpose of statistical estimation of rainfall from multiple (radar and raingage) sensors. Raingage, radar, and joint radar-raingage estimation is described, and some results are given. Statistical parameters of rainfall spatial dependence are calculated and discussed in the context of optimal estimation. Quality control of radar data is also described. The second part describes radar scattering by ellipsoidal raindrops. An analytical solution is derived for the Rayleigh scattering regime. Single and volume scattering are presented. Comparison calculations with the known results for spheres and oblate spheroids are shown.

Sequential Modelling of Building Rooftops by Integrating Airborne LIDAR Data and Optical Imagery: Preliminary Results

NASA Astrophysics Data System (ADS)

Sohn, G.; Jung, J.; Jwa, Y.; Armenakis, C.

2013-05-01

This paper presents a sequential rooftop modelling method to refine initial rooftop models derived from airborne LiDAR data by integrating it with linear cues retrieved from single imagery. A cue integration between two datasets is facilitated by creating new topological features connecting between the initial model and image lines, with which new model hypotheses (variances to the initial model) are produced. We adopt Minimum Description Length (MDL) principle for competing the model candidates and selecting the optimal model by considering the balanced trade-off between the model closeness and the model complexity. Our preliminary results, combined with the Vaihingen data provided by ISPRS WGIII/4 demonstrate the image-driven modelling cues can compensate the limitations posed by LiDAR data in rooftop modelling.

Scorpion: Close Air Support (CAS) aircraft

NASA Technical Reports Server (NTRS)

Allen, Chris; Cheng, Rendy; Koehler, Grant; Lyon, Sean; Paguio, Cecilia

1991-01-01

The objective is to outline the results of the preliminary design of the Scorpion, a proposed close air support aircraft. The results obtained include complete preliminary analysis of the aircraft in the areas of aerodynamics, structures, avionics and electronics, stability and control, weight and balance, propulsion systems, and costs. A conventional wing, twin jet, twin-tail aircraft was chosen to maximize the desirable characteristics. The Scorpion will feature low speed maneuverability, high survivability, low cost, and low maintenance. The life cycle cost per aircraft will be 17.5 million dollars. The maximum takeoff weight will be 52,760 pounds. Wing loading will be 90 psf. The thrust to weight will be 0.6 lbs/lb. This aircraft meets the specified mission requirements. Some modifications have been suggested to further optimize the design.

Preliminary flight evaluation of an engine performance optimization algorithm

NASA Technical Reports Server (NTRS)

Lambert, H. H.; Gilyard, G. B.; Chisholm, J. D.; Kerr, L. J.

1991-01-01

A performance seeking control (PSC) algorithm has undergone initial flight test evaluation in subsonic operation of a PW 1128 engined F-15. This algorithm is designed to optimize the quasi-steady performance of an engine for three primary modes: (1) minimum fuel consumption; (2) minimum fan turbine inlet temperature (FTIT); and (3) maximum thrust. The flight test results have verified a thrust specific fuel consumption reduction of 1 pct., up to 100 R decreases in FTIT, and increases of as much as 12 pct. in maximum thrust. PSC technology promises to be of value in next generation tactical and transport aircraft.

Evolutionary computing for the design search and optimization of space vehicle power subsystems

NASA Technical Reports Server (NTRS)

Kordon, Mark; Klimeck, Gerhard; Hanks, David; Hua, Hook

2004-01-01

Evolutionary computing has proven to be a straightforward and robust approach for optimizing a wide range of difficult analysis and design problems. This paper discusses the application of these techniques to an existing space vehicle power subsystem resource and performance analysis simulation in a parallel processing environment. Out preliminary results demonstrate that this approach has the potential to improve the space system trade study process by allowing engineers to statistically weight subsystem goals of mass, cost and performance then automatically size power elements based on anticipated performance of the subsystem rather than on worst-case estimates.

Controlled supercontinua via spatial beam shaping

NASA Astrophysics Data System (ADS)

Zhdanova, Alexandra A.; Shen, Yujie; Thompson, Jonathan V.; Scully, Marlan O.; Yakovlev, Vladislav V.; Sokolov, Alexei V.

2018-06-01

Recently, optimization techniques have had a significant impact in a variety of fields, leading to a higher signal-to-noise and more streamlined techniques. We consider the possibility for using programmable phase-only spatial optimization of the pump beam to influence the supercontinuum generation process. Preliminary results show that significant broadening and rough control of the supercontinuum spectrum in the visible region are possible without loss of input energy. This serves as a proof-of-concept demonstration that spatial effects can controllably influence the supercontinuum spectrum, leading to possibilities for utilizing supercontinuum power more efficiently and achieving excellent spectral control.

A Numerical-Analytical Approach Based on Canonical Transformations for Computing Optimal Low-Thrust Transfers

NASA Astrophysics Data System (ADS)

da Silva Fernandes, S.; das Chagas Carvalho, F.; Bateli Romão, J. V.

2018-04-01

A numerical-analytical procedure based on infinitesimal canonical transformations is developed for computing optimal time-fixed low-thrust limited power transfers (no rendezvous) between coplanar orbits with small eccentricities in an inverse-square force field. The optimization problem is formulated as a Mayer problem with a set of non-singular orbital elements as state variables. Second order terms in eccentricity are considered in the development of the maximum Hamiltonian describing the optimal trajectories. The two-point boundary value problem of going from an initial orbit to a final orbit is solved by means of a two-stage Newton-Raphson algorithm which uses an infinitesimal canonical transformation. Numerical results are presented for some transfers between circular orbits with moderate radius ratio, including a preliminary analysis of Earth-Mars and Earth-Venus missions.

Optimal pricing and marketing planning for deteriorating items.

PubMed

Moosavi Tabatabaei, Seyed Reza; Sadjadi, Seyed Jafar; Makui, Ahmad

2017-01-01

Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and after-sales service expenditures. The proposed model is formulated as a geometric programming with 5 degrees of difficulty and the problem is solved using the recent advances in optimization techniques. The study is supported by several numerical examples and sensitivity analysis is performed to analyze the effects of the changes in different parameters on the optimal solution. The preliminary results indicate that with the change in parameters influencing on demand, inventory holding, inventory deteriorating and set-up costs change and also significantly affect total revenue.

Parallel-vector computation for linear structural analysis and non-linear unconstrained optimization problems

NASA Technical Reports Server (NTRS)

Nguyen, D. T.; Al-Nasra, M.; Zhang, Y.; Baddourah, M. A.; Agarwal, T. K.; Storaasli, O. O.; Carmona, E. A.

1991-01-01

Several parallel-vector computational improvements to the unconstrained optimization procedure are described which speed up the structural analysis-synthesis process. A fast parallel-vector Choleski-based equation solver, pvsolve, is incorporated into the well-known SAP-4 general-purpose finite-element code. The new code, denoted PV-SAP, is tested for static structural analysis. Initial results on a four processor CRAY 2 show that using pvsolve reduces the equation solution time by a factor of 14-16 over the original SAP-4 code. In addition, parallel-vector procedures for the Golden Block Search technique and the BFGS method are developed and tested for nonlinear unconstrained optimization. A parallel version of an iterative solver and the pvsolve direct solver are incorporated into the BFGS method. Preliminary results on nonlinear unconstrained optimization test problems, using pvsolve in the analysis, show excellent parallel-vector performance indicating that these parallel-vector algorithms can be used in a new generation of finite-element based structural design/analysis-synthesis codes.

Galaxy Redshifts from Discrete Optimization of Correlation Functions

NASA Astrophysics Data System (ADS)

Lee, Benjamin C. G.; Budavári, Tamás; Basu, Amitabh; Rahman, Mubdi

2016-12-01

We propose a new method of constraining the redshifts of individual extragalactic sources based on celestial coordinates and their ensemble statistics. Techniques from integer linear programming (ILP) are utilized to optimize simultaneously for the angular two-point cross- and autocorrelation functions. Our novel formalism introduced here not only transforms the otherwise hopelessly expensive, brute-force combinatorial search into a linear system with integer constraints but also is readily implementable in off-the-shelf solvers. We adopt Gurobi, a commercial optimization solver, and use Python to build the cost function dynamically. The preliminary results on simulated data show potential for future applications to sky surveys by complementing and enhancing photometric redshift estimators. Our approach is the first application of ILP to astronomical analysis.

Density-Difference-Driven Optimized Embedding Potential Method To Study the Spectroscopy of Br₂ in Water Clusters.

PubMed

Roncero, Octavio; Aguado, Alfredo; Batista-Romero, Fidel A; Bernal-Uruchurtu, Margarita I; Hernández-Lamoneda, Ramón

2015-03-10

A variant of the density difference driven optimized embedding potential (DDD-OEP) method, proposed by Roncero et al. (J. Chem. Phys. 2009, 131, 234110), has been applied to the calculation of excited states of Br2 within small water clusters. It is found that the strong interaction of Br2 with the lone electronic pair of the water molecules makes necessary to optimize specific embedding potentials for ground and excited electronic states, separately and using the corresponding densities. Diagnosis and convergence studies are presented with the aim of providing methods to be applied for the study of chromophores in solution. Also, some preliminary results obtained for the study of electronic states of Br2 in clathrate cages are presented.

The benefits of adaptive parametrization in multi-objective Tabu Search optimization

NASA Astrophysics Data System (ADS)

Ghisu, Tiziano; Parks, Geoffrey T.; Jaeggi, Daniel M.; Jarrett, Jerome P.; Clarkson, P. John

2010-10-01

In real-world optimization problems, large design spaces and conflicting objectives are often combined with a large number of constraints, resulting in a highly multi-modal, challenging, fragmented landscape. The local search at the heart of Tabu Search, while being one of its strengths in highly constrained optimization problems, requires a large number of evaluations per optimization step. In this work, a modification of the pattern search algorithm is proposed: this modification, based on a Principal Components' Analysis of the approximation set, allows both a re-alignment of the search directions, thereby creating a more effective parametrization, and also an informed reduction of the size of the design space itself. These changes make the optimization process more computationally efficient and more effective - higher quality solutions are identified in fewer iterations. These advantages are demonstrated on a number of standard analytical test functions (from the ZDT and DTLZ families) and on a real-world problem (the optimization of an axial compressor preliminary design).

Neural network for nonsmooth pseudoconvex optimization with general convex constraints.

PubMed

Bian, Wei; Ma, Litao; Qin, Sitian; Xue, Xiaoping

2018-05-01

In this paper, a one-layer recurrent neural network is proposed for solving a class of nonsmooth, pseudoconvex optimization problems with general convex constraints. Based on the smoothing method, we construct a new regularization function, which does not depend on any information of the feasible region. Thanks to the special structure of the regularization function, we prove the global existence, uniqueness and "slow solution" character of the state of the proposed neural network. Moreover, the state solution of the proposed network is proved to be convergent to the feasible region in finite time and to the optimal solution set of the related optimization problem subsequently. In particular, the convergence of the state to an exact optimal solution is also considered in this paper. Numerical examples with simulation results are given to show the efficiency and good characteristics of the proposed network. In addition, some preliminary theoretical analysis and application of the proposed network for a wider class of dynamic portfolio optimization are included. Copyright © 2018 Elsevier Ltd. All rights reserved.

Integration of a CAD System Into an MDO Framework

NASA Technical Reports Server (NTRS)

Townsend, J. C.; Samareh, J. A.; Weston, R. P.; Zorumski, W. E.

1998-01-01

NASA Langley has developed a heterogeneous distributed computing environment, called the Framework for Inter-disciplinary Design Optimization, or FIDO. Its purpose has been to demonstrate framework technical feasibility and usefulness for optimizing the preliminary design of complex systems and to provide a working environment for testing optimization schemes. Its initial implementation has been for a simplified model of preliminary design of a high-speed civil transport. Upgrades being considered for the FIDO system include a more complete geometry description, required by high-fidelity aerodynamics and structures codes and based on a commercial Computer Aided Design (CAD) system. This report presents the philosophy behind some of the decisions that have shaped the FIDO system and gives a brief case study of the problems and successes encountered in integrating a CAD system into the FEDO framework.

Application of decomposition techniques to the preliminary design of a transport aircraft

NASA Technical Reports Server (NTRS)

Rogan, J. E.; Mcelveen, R. P.; Kolb, M. A.

1986-01-01

A multifaceted decomposition of a nonlinear constrained optimization problem describing the preliminary design process for a transport aircraft has been made. Flight dynamics, flexible aircraft loads and deformations, and preliminary structural design subproblems appear prominently in the decomposition. The use of design process decomposition for scheduling design projects, a new system integration approach to configuration control, and the application of object-centered programming to a new generation of design tools are discussed.

Sail Plan Configuration Optimization for a Modern Clipper Ship

NASA Astrophysics Data System (ADS)

Gerritsen, Margot; Doyle, Tyler; Iaccarino, Gianluca; Moin, Parviz

2002-11-01

We investigate the use of gradient-based and evolutionary algorithms for sail shape optimization. We present preliminary results for the optimization of sheeting angles for the rig of the future three-masted clipper yacht Maltese Falcon. This yacht will be equipped with square-rigged masts made up of yards of circular arc cross sections. This design is especially attractive for megayachts because it provides a large sail area while maintaining aerodynamic and structural efficiency. The rig remains almost rigid in a large range of wind conditions and therefore a simple geometrical model can be constructed without accounting for the true flying shape. The sheeting angle optimization studies are performed using both gradient-based cost function minimization and evolutionary algorithms. The fluid flow is modeled by the Reynolds-averaged Navier-Stokes equations with the Spallart-Allmaras turbulence model. Unstructured non-conforming grids are used to increase robustness and computational efficiency. The optimization process is automated by integrating the system components (geometry construction, grid generation, flow solver, force calculator, optimization). We compare the optimization results to those done previously by user-controlled parametric studies using simple cost functions and user intuition. We also investigate the effectiveness of various cost functions in the optimization (driving force maximization, ratio of driving force to heeling force maximization).

Preliminary analysis of a membrane-based atmosphere-control subsystem

NASA Technical Reports Server (NTRS)

Mccray, Scott B.; Newbold, David D.; Ray, Rod; Ogle, Kathryn

1993-01-01

Controlled ecological life supprot systems will require subsystems for maintaining the consentrations of atmospheric gases within acceptable ranges in human habitat chambers and plant growth chambers. The goal of this work was to develop a membrane-based atmosphere comntrol (MBAC) subsystem that allows the controlled exchange of atmospheric componets (e.g., oxygen, carbon dioxide, and water vapor) between these chambers. The MBAC subsystem promises to offer a simple, nonenergy intensive method to separate, store and exchange atmospheric components, producing optimal concentrations of components in each chamber. In this paper, the results of a preliminary analysis of the MBAC subsystem for control of oxygen and nitrogen are presented. Additionally, the MBAC subsystem and its operation are described.

System Synthesis in Preliminary Aircraft Design using Statistical Methods

NASA Technical Reports Server (NTRS)

DeLaurentis, Daniel; Mavris, Dimitri N.; Schrage, Daniel P.

1996-01-01

This paper documents an approach to conceptual and preliminary aircraft design in which system synthesis is achieved using statistical methods, specifically design of experiments (DOE) and response surface methodology (RSM). These methods are employed in order to more efficiently search the design space for optimum configurations. In particular, a methodology incorporating three uses of these techniques is presented. First, response surface equations are formed which represent aerodynamic analyses, in the form of regression polynomials, which are more sophisticated than generally available in early design stages. Next, a regression equation for an overall evaluation criterion is constructed for the purpose of constrained optimization at the system level. This optimization, though achieved in a innovative way, is still traditional in that it is a point design solution. The methodology put forward here remedies this by introducing uncertainty into the problem, resulting a solutions which are probabilistic in nature. DOE/RSM is used for the third time in this setting. The process is demonstrated through a detailed aero-propulsion optimization of a high speed civil transport. Fundamental goals of the methodology, then, are to introduce higher fidelity disciplinary analyses to the conceptual aircraft synthesis and provide a roadmap for transitioning from point solutions to probabalistic designs (and eventually robust ones).

Design, synthesis and preliminary antimicrobial evaluation of n-alkyl chain tethered c-5 functionalized bis-isatins

USDA-ARS?s Scientific Manuscript database

A series of N-alkyl tethered C-5 functionalized bis-isatins were synthesized and evaluated for antimicrobial activity against pathogenic microorganisms. The preliminary evaluation studies revealed the compound 4t, with an optimal combination of bromo-substituent at the C-5 position of isatin ring al...

Adaptive Optimization of Aircraft Engine Performance Using Neural Networks

NASA Technical Reports Server (NTRS)

Simon, Donald L.; Long, Theresa W.

1995-01-01

Preliminary results are presented on the development of an adaptive neural network based control algorithm to enhance aircraft engine performance. This work builds upon a previous National Aeronautics and Space Administration (NASA) effort known as Performance Seeking Control (PSC). PSC is an adaptive control algorithm which contains a model of the aircraft's propulsion system which is updated on-line to match the operation of the aircraft's actual propulsion system. Information from the on-line model is used to adapt the control system during flight to allow optimal operation of the aircraft's propulsion system (inlet, engine, and nozzle) to improve aircraft engine performance without compromising reliability or operability. Performance Seeking Control has been shown to yield reductions in fuel flow, increases in thrust, and reductions in engine fan turbine inlet temperature. The neural network based adaptive control, like PSC, will contain a model of the propulsion system which will be used to calculate optimal control commands on-line. Hopes are that it will be able to provide some additional benefits above and beyond those of PSC. The PSC algorithm is computationally intensive, it is valid only at near steady-state flight conditions, and it has no way to adapt or learn on-line. These issues are being addressed in the development of the optimal neural controller. Specialized neural network processing hardware is being developed to run the software, the algorithm will be valid at steady-state and transient conditions, and will take advantage of the on-line learning capability of neural networks. Future plans include testing the neural network software and hardware prototype against an aircraft engine simulation. In this paper, the proposed neural network software and hardware is described and preliminary neural network training results are presented.

Partial Data Traces: Efficient Generation and Representation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mueller, F; De Supinski, B R; McKee, S A

2001-08-20

Binary manipulation techniques are increasing in popularity. They support program transformations tailored toward certain program inputs, and these transformations have been shown to yield performance gains beyond the scope of static code optimizations without profile-directed feedback. They even deliver moderate gains in the presence of profile-guided optimizations. In addition, transformations can be performed on the entire executable, including library routines. This work focuses on program instrumentation, yet another application of binary manipulation. This paper reports preliminary results on generating partial data traces through dynamic binary rewriting. The contributions are threefold. First, a portable method for extracting precise data traces formore » partial executions of arbitrary applications is developed. Second, a set of hierarchical structures for compactly representing these accesses is developed. Third, an efficient online algorithm to detect regular accesses is introduced. The authors utilize dynamic binary rewriting to selectively collect partial address traces of regions within a program. This allows partial tracing of hot paths for only a short time during program execution in contrast to static rewriting techniques that lack hot path detection and also lack facilities to limit the duration of data collection. Preliminary results show reductions of three orders of a magnitude of inline instrumentation over a dual process approach involving context switching. They also report constant size representations for regular access patters in nested loops. These efforts are part of a larger project to counter the increasing gap between processor and main memory speeds by means of software optimization and hardware enhancements.« less

A comprehensive method for preliminary design optimization of axial gas turbine stages

NASA Technical Reports Server (NTRS)

Jenkins, R. M.

1982-01-01

A method is presented that performs a rapid, reasonably accurate preliminary pitchline optimization of axial gas turbine annular flowpath geometry, as well as an initial estimate of blade profile shapes, given only a minimum of thermodynamic cycle requirements. No geometric parameters need be specified. The following preliminary design data are determined: (1) the optimum flowpath geometry, within mechanical stress limits; (2) initial estimates of cascade blade shapes; (3) predictions of expected turbine performance. The method uses an inverse calculation technique whereby blade profiles are generated by designing channels to yield a specified velocity distribution on the two walls. Velocity distributions are then used to calculate the cascade loss parameters. Calculated blade shapes are used primarily to determine whether the assumed velocity loadings are physically realistic. Model verification is accomplished by comparison of predicted turbine geometry and performance with four existing single stage turbines.

RLV Turbine Performance Optimization

NASA Technical Reports Server (NTRS)

Griffin, Lisa W.; Dorney, Daniel J.

2001-01-01

A task was developed at NASA/Marshall Space Flight Center (MSFC) to improve turbine aerodynamic performance through the application of advanced design and analysis tools. There are four major objectives of this task: 1) to develop, enhance, and integrate advanced turbine aerodynamic design and analysis tools; 2) to develop the methodology for application of the analytical techniques; 3) to demonstrate the benefits of the advanced turbine design procedure through its application to a relevant turbine design point; and 4) to verify the optimized design and analysis with testing. Final results of the preliminary design and the results of the two-dimensional (2D) detailed design of the first-stage vane of a supersonic turbine suitable for a reusable launch vehicle (R-LV) are presented. Analytical techniques for obtaining the results are also discussed.

Recent developments in large-scale structural optimization

NASA Technical Reports Server (NTRS)

Venkayya, Vipperla B.

1989-01-01

A brief discussion is given of mathematical optimization and the motivation for the development of more recent numerical search procedures. A review of recent developments and issues in multidisciplinary optimization is also presented. These developments are discussed in the context of the preliminary design of aircraft structures. A capability description of programs FASTOP, TSO, STARS, LAGRANGE, ELFINI and ASTROS is included.

A hydrophone prototype for ultra high energy neutrino acoustic detection

NASA Astrophysics Data System (ADS)

Cotrufo, A.; Plotnikov, A.; Yershova, O.; Anghinolfi, M.; Piombo, D.

2009-06-01

The design of an air-backed fiber-optic hydrophone is presented. With respect to the previous models this prototype is optimized to provide a bandwidth sufficiently large to detect acoustic signals produced by high energy hadronic showers in water. In addiction to the geometrical configuration and to the choice of the materials, the preliminary results of the measured performances in air are presented.

A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists.

PubMed

Dordal, Alberto; Lipkin, Mike; Macritchie, Jackie; Mas, Josep; Port, Adriana; Rose, Sally; Salgado, Leonardo; Savic, Vladimir; Schmidt, Wolfgang; Serafini, Maria Teresa; Spearing, William; Torrens, Antoni; Yeste, Sandra

2005-08-15

The metabolic stability of benzoxazinone derivatives, a potent series of NPY Y5 antagonists, has been investigated. This study resulted in the identification of the structural moieties prone to metabolic transformations and which strongly influenced the in vitro half-life. This provides opportunities to optimize the structure of this new class of NPY Y5 antagonists.

Optimization in the systems engineering process

NASA Technical Reports Server (NTRS)

Lemmerman, Loren A.

1993-01-01

The essential elements of the design process consist of the mission definition phase that provides the system requirements, the conceptual design, the preliminary design and finally the detailed design. Mission definition is performed largely by operations analysts in conjunction with the customer. The result of their study is handed off to the systems engineers for documentation as the systems requirements. The document that provides these requirements is the basis for the further design work of the design engineers at the Lockheed-Georgia Company. The design phase actually begins with conceptual design, which is generally conducted by a small group of engineers using multidisciplinary design programs. Because of the complexity of the design problem, the analyses are relatively simple and generally dependent on parametric analyses of the configuration. The result of this phase is a baseline configuration from which preliminary design may be initiated.

Poster — Thur Eve — 61: A new framework for MPERT plan optimization using MC-DAO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, M; Lloyd, S AM; Townson, R

2014-08-15

This work combines the inverse planning technique known as Direct Aperture Optimization (DAO) with Intensity Modulated Radiation Therapy (IMRT) and combined electron and photon therapy plans. In particular, determining conditions under which Modulated Photon/Electron Radiation Therapy (MPERT) produces better dose conformality and sparing of organs at risk than traditional IMRT plans is central to the project. Presented here are the materials and methods used to generate and manipulate the DAO procedure. Included is the introduction of a powerful Java-based toolkit, the Aperture-based Monte Carlo (MC) MPERT Optimizer (AMMO), that serves as a framework for optimization and provides streamlined access tomore » underlying particle transport packages. Comparison of the toolkit's dose calculations to those produced by the Eclipse TPS and the demonstration of a preliminary optimization are presented as first benchmarks. Excellent agreement is illustrated between the Eclipse TPS and AMMO for a 6MV photon field. The results of a simple optimization shows the functioning of the optimization framework, while significant research remains to characterize appropriate constraints.« less

Optimal pricing and marketing planning for deteriorating items

PubMed Central

Moosavi Tabatabaei, Seyed Reza; Sadjadi, Seyed Jafar; Makui, Ahmad

2017-01-01

Optimal pricing and marketing planning plays an essential role in production decisions on deteriorating items. This paper presents a mathematical model for a three-level supply chain, which includes one producer, one distributor and one retailer. The proposed study considers the production of a deteriorating item where demand is influenced by price, marketing expenditure, quality of product and after-sales service expenditures. The proposed model is formulated as a geometric programming with 5 degrees of difficulty and the problem is solved using the recent advances in optimization techniques. The study is supported by several numerical examples and sensitivity analysis is performed to analyze the effects of the changes in different parameters on the optimal solution. The preliminary results indicate that with the change in parameters influencing on demand, inventory holding, inventory deteriorating and set-up costs change and also significantly affect total revenue. PMID:28306750

Optimizing Excited-State Electronic-Structure Codes for Intel Knights Landing: A Case Study on the BerkeleyGW Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deslippe, Jack; da Jornada, Felipe H.; Vigil-Fowler, Derek

2016-10-06

We profile and optimize calculations performed with the BerkeleyGW code on the Xeon-Phi architecture. BerkeleyGW depends both on hand-tuned critical kernels as well as on BLAS and FFT libraries. We describe the optimization process and performance improvements achieved. We discuss a layered parallelization strategy to take advantage of vector, thread and node-level parallelism. We discuss locality changes (including the consequence of the lack of L3 cache) and effective use of the on-package high-bandwidth memory. We show preliminary results on Knights-Landing including a roofline study of code performance before and after a number of optimizations. We find that the GW methodmore » is particularly well-suited for many-core architectures due to the ability to exploit a large amount of parallelism over plane-wave components, band-pairs, and frequencies.« less

Actinobacillus succinogenes ATCC 55618 Fermentation Medium Optimization for the Production of Succinic Acid by Response Surface Methodology

PubMed Central

Zhu, Li-Wen; Wang, Cheng-Cheng; Liu, Rui-Sang; Li, Hong-Mei; Wan, Duan-Ji; Tang, Ya-Jie

2012-01-01

As a potential intermediary feedstock, succinic acid takes an important place in bulk chemical productions. For the first time, a method combining Plackett-Burman design (PBD), steepest ascent method (SA), and Box-Behnken design (BBD) was developed to optimize Actinobacillus succinogenes ATCC 55618 fermentation medium. First, glucose, yeast extract, and MgCO3 were identified to be key medium components by PBD. Second, preliminary optimization was run by SA method to access the optimal region of the key medium components. Finally, the responses, that is, the production of succinic acid, were optimized simultaneously by using BBD, and the optimal concentration was located to be 84.6 g L−1 of glucose, 14.5 g L−1 of yeast extract, and 64.7 g L−1 of MgCO3. Verification experiment indicated that the maximal succinic acid production of 52.7 ± 0.8 g L−1 was obtained under the identified optimal conditions. The result agreed with the predicted value well. Compared with that of the basic medium, the production of succinic acid and yield of succinic acid against glucose were enhanced by 67.3% and 111.1%, respectively. The results obtained in this study may be useful for the industrial commercial production of succinic acid. PMID:23093852

Global Optimization of Interplanetary Trajectories in the Presence of Realistic Mission Contraints

NASA Technical Reports Server (NTRS)

Hinckley, David, Jr.; Englander, Jacob; Hitt, Darren

2015-01-01

Interplanetary missions are often subject to difficult constraints, like solar phase angle upon arrival at the destination, velocity at arrival, and altitudes for flybys. Preliminary design of such missions is often conducted by solving the unconstrained problem and then filtering away solutions which do not naturally satisfy the constraints. However this can bias the search into non-advantageous regions of the solution space, so it can be better to conduct preliminary design with the full set of constraints imposed. In this work two stochastic global search methods are developed which are well suited to the constrained global interplanetary trajectory optimization problem.

ARRAY OPTIMIZATION FOR TIDAL ENERGY EXTRACTION IN A TIDAL CHANNEL – A NUMERICAL MODELING ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Zhaoqing; Wang, Taiping; Copping, Andrea

This paper presents an application of a hydrodynamic model to simulate tidal energy extraction in a tidal dominated estuary in the Pacific Northwest coast. A series of numerical experiments were carried out to simulate tidal energy extraction with different turbine array configurations, including location, spacing and array size. Preliminary model results suggest that array optimization for tidal energy extraction in a real-world site is a very complex process that requires consideration of multiple factors. Numerical models can be used effectively to assist turbine siting and array arrangement in a tidal turbine farm for tidal energy extraction.

Mode-field adapter for tapered-fiber-bundle signal and pump combiners.

PubMed

Koška, Pavel; Baravets, Yauhen; Peterka, Pavel; Bohata, Jan; Písařík, Michael

2015-02-01

We report on a novel mode-field adapter that is proposed to be incorporated inside tapered fused-fiber-bundle pump and signal combiners for high-power double-clad fiber lasers. Such an adapter allows optimization of signal-mode-field matching on the input and output fibers. Correspondingly, losses of the combiner signal branch are significantly reduced. The mode-field adapter optimization procedure is demonstrated on a combiner based on commercially available fibers. Signal wavelengths of 1.55 and 2 μm are considered. The losses can be further improved by using specially designed intermediate fiber and by dopant diffusion during splicing as confirmed by preliminary experimental results.

Practical automated glass selection and the design of apochromats with large field of view.

PubMed

Siew, Ronian

2016-11-10

This paper presents an automated approach to the selection of optical glasses for the design of an apochromatic lens with large field of view, based on a design originally provided by Yang et al. [Appl. Opt.55, 5977 (2016)APOPAI0003-693510.1364/AO.55.005977]. Following from this reference's preliminary optimized structure, it is shown that the effort of glass selection is significantly reduced by using the global optimization feature in the Zemax optical design program. The glass selection process is very fast, complete within minutes, and the key lies in automating the substitution of glasses found from the global search without the need to simultaneously optimize any other lens parameter during the glass search. The result is an alternate optimized version of the lens from the above reference possessing zero axial secondary color within the visible spectrum and a large field of view. Supplementary material is provided in the form of Zemax and text files, before and after final optimization.

Desiccant humidity control system

NASA Technical Reports Server (NTRS)

Amazeen, J. (Editor)

1973-01-01

A regenerable sorbent system was investigated for controlling the humidity and carbon dioxide concentration of the space shuttle cabin atmosphere. The sorbents considered for water and carbon dioxide removal were silica gel and molecular sieves. Bed optimization and preliminary system design are discussed along with system optimization studies and weight penalites.

Application of genetic algorithm in modeling on-wafer inductors for up to 110 Ghz

NASA Astrophysics Data System (ADS)

Liu, Nianhong; Fu, Jun; Liu, Hui; Cui, Wenpu; Liu, Zhihong; Liu, Linlin; Zhou, Wei; Wang, Quan; Guo, Ao

2018-05-01

In this work, the genetic algorithm has been introducted into parameter extraction for on-wafer inductors for up to 110 GHz millimeter-wave operations, and nine independent parameters of the equivalent circuit model are optimized together. With the genetic algorithm, the model with the optimized parameters gives a better fitting accuracy than the preliminary parameters without optimization. Especially, the fitting accuracy of the Q value achieves a significant improvement after the optimization.

4MOST fiber feed preliminary design: prototype testing and performance

NASA Astrophysics Data System (ADS)

Haynes, Dionne M.; Kelz, Andreas; Barden, Samuel C.; Bauer, Svend-Marian; Ehrlich, Katjana; Haynes, Roger; Jahn, Thomas; Saviauk, Allar; de Jong, Roelof S.

2016-08-01

The 4MOST instrument is a multi-object-spectrograph for the ESO-VISTA telescope. The 4MOST fiber feed subsystem is composed of a fiber positioner (AESOP) holding 2436 science fibers based on the Echidna tilting spine concept, and the fiber cable, which feeds two low-resolution spectrographs (1624 fibers) and one high-resolution spectrograph (812 fibers). In order to optimize the fiber feed subsystem design and provide essential information required for the spectrograph design, prototyping and testing has been undertaken. In this paper we give an overview of the current fiber feed subsystem design and present the preliminary FRD, scrambling, throughput and system performance impact results for: maximum and minimum spine tilt, fiber connectors, cable de-rotator simulator for fiber cable lifetime tests.

Poly ɛ-caprolactone nanoparticles loaded with Uncaria tomentosa extract: preparation, characterization, and optimization using the Box–Behnken design

PubMed Central

Ribeiro, Ana Ferreira; de Oliveira Rezende, Ricardo Leite; Cabral, Lúcio Mendes; de Sousa, Valéria Pereira

2013-01-01

Purpose The aim of this research was to develop and optimize a process for obtaining poly ɛ-caprolactone (PCL) nanoparticles loaded with Uncaria tomentosa (UT) extract. Methods Nanoparticles were produced by the oil-in-water emulsion solvent evaporation method. Preliminary experiments determined the initial conditions of the organic phase (OP) and of the aqueous phase (AP) that would be utilized for this study. Ultimately, a three-factor three-level Box–Behnken design (BBD) was employed during the optimization process. PCL and polyvinyl alcohol (PVA) concentrations (X1 and X2, respectively) and the AP/OP volume ratio (X3) were the independent variables studied, while entrapment efficiency (Y1), particle mean diameter (Y2), polydispersity (Y3), and zeta potential (Y4) served as the evaluated responses. Results Preliminary experiments revealed that the optimal initial conditions for the preparation of nanoparticles were as follows: OP composed of 5 mL ethyl acetate/acetone (3/2) mixture containing UT extract and PCL, and an AP of buffered PVA (pH 7.5) solution. Statistical analysis of the BBD results indicated that all of the studied factors had significant effects on the responses Y1, Y2, and Y4, and these effects are closely described or fitted by regression equations. Based on the obtained models and the selected desirability function, the nanoparticles were optimized to maximize Y1 and minimize Y2. These optimal conditions were achieved using 3% (w/v) PCL, 1% (w/v) PVA, and an AP/OP ratio of 1.7, with predicted values of 89.1% for Y1 and 280 nm for Y2. Another batch was produced under the same optimal conditions. The entrapment efficiency of this new batch was measured at 81.6% (Y1) and the particles had a mean size of 247 nm (Y2) and a polydispersity index of 0.062 (Y3). Conclusion This investigation obtained UT-loaded nanoparticle formulations with desired characteristics. The BBD approach was a useful tool for nanoparticle development and optimization, and thus should be useful especially in the realm of phytotherapeutics, in which varied compositions may be assessed in quantitative and qualitative terms. PMID:23378765

Are genetically robust regulatory networks dynamically different from random ones?

NASA Astrophysics Data System (ADS)

Sevim, Volkan; Rikvold, Per Arne

We study a genetic regulatory network model developed to demonstrate that genetic robustness can evolve through stabilizing selection for optimal phenotypes. We report preliminary results on whether such selection could result in a reorganization of the state space of the system. For the chosen parameters, the evolution moves the system slightly toward the more ordered part of the phase diagram. We also find that strong memory effects cause the Derrida annealed approximation to give erroneous predictions about the model's phase diagram.

From measurements to metrics: PCA-based indicators of cyber anomaly

NASA Astrophysics Data System (ADS)

Ahmed, Farid; Johnson, Tommy; Tsui, Sonia

2012-06-01

We present a framework of the application of Principal Component Analysis (PCA) to automatically obtain meaningful metrics from intrusion detection measurements. In particular, we report the progress made in applying PCA to analyze the behavioral measurements of malware and provide some preliminary results in selecting dominant attributes from an arbitrary number of malware attributes. The results will be useful in formulating an optimal detection threshold in the principal component space, which can both validate and augment existing malware classifiers.

Ares I Scale Model Acoustic Test Above Deck Water Sound Suppression Results

NASA Technical Reports Server (NTRS)

Counter, Douglas D.; Houston, Janice D.

2011-01-01

The Ares I Scale Model Acoustic Test (ASMAT) program test matrix was designed to determine the acoustic reduction for the Liftoff acoustics (LOA) environment with an above deck water sound suppression system. The scale model test can be used to quantify the effectiveness of the water suppression system as well as optimize the systems necessary for the LOA noise reduction. Several water flow rates were tested to determine which rate provides the greatest acoustic reductions. Preliminary results are presented.

4MOST systems engineering: from conceptual design to preliminary design review

NASA Astrophysics Data System (ADS)

Bellido-Tirado, Olga; Frey, Steffen; Barden, Samuel C.; Brynnel, Joar; Giannone, Domenico; Haynes, Roger; de Jong, Roelof S.; Phillips, Daniel; Schnurr, Olivier; Walcher, Jakob; Winkler, Roland

2016-08-01

The 4MOST Facility is a high-multiplex, wide-field, brief-fed spectrograph system for the ESO VISTA telescope. It aims to create a world-class spectroscopic survey facility unique in its combination of wide-field multiplex, spectral resolution, spectral coverage, and sensitivity. At the end of 2014, after a successful concept optimization design phase, 4MOST entered into its Preliminary Design Phase. Here we present the process and tools adopted during the Preliminary Design Phase to define the subsystems specifications, coordinate the interface control documents and draft the system verification procedures.

Electron bunch energy and phase feed-forward stabilization system for the Mark V RF-linac free-electron laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadmack, M. R.; Kowalczyk, J. M. D.; Lienert, B. R.

2013-06-15

An amplitude and phase compensation system has been developed and tested at the University of Hawai'i for the optimization of the RF drive system to the Mark V free-electron laser. Temporal uniformity of the RF drive is essential to the generation of an electron beam suitable for optimal free-electron laser performance and the operation of an inverse Compton scattering x-ray source. The design of the RF measurement and compensation system is described in detail and the results of RF phase compensation are presented. Performance of the free-electron laser was evaluated by comparing the measured effects of phase compensation with themore » results of a computer simulation. Finally, preliminary results are presented for the effects of amplitude compensation on the performance of the complete system.« less

A Simulation Optimization Approach to Epidemic Forecasting

PubMed Central

Nsoesie, Elaine O.; Beckman, Richard J.; Shashaani, Sara; Nagaraj, Kalyani S.; Marathe, Madhav V.

2013-01-01

Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast the epidemic curve and infer underlying model parameters during an influenza outbreak. The SIMOP procedure combines an individual-based model and the Nelder-Mead simplex optimization method. The method is used to forecast epidemics simulated over synthetic social networks representing Montgomery County in Virginia, Miami, Seattle and surrounding metropolitan regions. The results are presented for the first four weeks. Depending on the synthetic network, the peak time could be predicted within a 95% CI as early as seven weeks before the actual peak. The peak infected and total infected were also accurately forecasted for Montgomery County in Virginia within the forecasting period. Forecasting of the epidemic curve for both seasonal and pandemic influenza outbreaks is a complex problem, however this is a preliminary step and the results suggest that more can be achieved in this area. PMID:23826222

A Simulation Optimization Approach to Epidemic Forecasting.

PubMed

Nsoesie, Elaine O; Beckman, Richard J; Shashaani, Sara; Nagaraj, Kalyani S; Marathe, Madhav V

2013-01-01

Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast the epidemic curve and infer underlying model parameters during an influenza outbreak. The SIMOP procedure combines an individual-based model and the Nelder-Mead simplex optimization method. The method is used to forecast epidemics simulated over synthetic social networks representing Montgomery County in Virginia, Miami, Seattle and surrounding metropolitan regions. The results are presented for the first four weeks. Depending on the synthetic network, the peak time could be predicted within a 95% CI as early as seven weeks before the actual peak. The peak infected and total infected were also accurately forecasted for Montgomery County in Virginia within the forecasting period. Forecasting of the epidemic curve for both seasonal and pandemic influenza outbreaks is a complex problem, however this is a preliminary step and the results suggest that more can be achieved in this area.

Engine performance analysis and optimization of a dual-mode scramjet with varied inlet conditions

NASA Astrophysics Data System (ADS)

Tian, Lu; Chen, Li-Hong; Chen, Qiang; Zhong, Feng-Quan; Chang, Xin-Yu

2016-02-01

A dual-mode scramjet can operate in a wide range of flight conditions. Higher thrust can be generated by adopting suitable combustion modes. Based on the net thrust, an analysis and preliminary optimal design of a kerosene-fueled parameterized dual-mode scramjet at a crucial flight Mach number of 6 were investigated by using a modified quasi-one-dimensional method and simulated annealing strategy. Engine structure and heat release distributions, affecting the engine thrust, were chosen as analytical parameters for varied inlet conditions (isolator entrance Mach number: 1.5-3.5). Results show that different optimal heat release distributions and structural conditions can be obtained at five different inlet conditions. The highest net thrust of the parameterized dual-mode engine can be achieved by a subsonic combustion mode at an isolator entrance Mach number of 2.5. Additionally, the effects of heat release and scramjet structure on net thrust have been discussed. The present results and the developed analytical method can provide guidance for the design and optimization of high-performance dual-mode scramjets.

Development of a solar-powered residential air conditioner: System optimization preliminary specification

NASA Technical Reports Server (NTRS)

Rousseau, J.; Hwang, K. C.

1975-01-01

Investigations aimed at the optimization of a baseline Rankine cycle solar powered air conditioner and the development of a preliminary system specification were conducted. Efforts encompassed the following: (1) investigations of the use of recuperators/regenerators to enhance the performance of the baseline system, (2) development of an off-design computer program for system performance prediction, (3) optimization of the turbocompressor design to cover a broad range of conditions and permit operation at low heat source water temperatures, (4) generation of parametric data describing system performance (COP and capacity), (5) development and evaluation of candidate system augmentation concepts and selection of the optimum approach, (6) generation of auxiliary power requirement data, (7) development of a complete solar collector-thermal storage-air conditioner computer program, (8) evaluation of the baseline Rankine air conditioner over a five day period simulating the NASA solar house operation, and (9) evaluation of the air conditioner as a heat pump.

Rapid Preliminary Design of Interplanetary Trajectories Using the Evolutionary Mission Trajectory Generator

NASA Technical Reports Server (NTRS)

Englander, Jacob

2016-01-01

Preliminary design of interplanetary missions is a highly complex process. The mission designer must choose discrete parameters such as the number of flybys, the bodies at which those flybys are performed, and in some cases the final destination. In addition, a time-history of control variables must be chosen that defines the trajectory. There are often many thousands, if not millions, of possible trajectories to be evaluated. This can be a very expensive process in terms of the number of human analyst hours required. An automated approach is therefore very desirable. This work presents such an approach by posing the mission design problem as a hybrid optimal control problem. The method is demonstrated on notional high-thrust chemical and low-thrust electric propulsion missions. In the low-thrust case, the hybrid optimal control problem is augmented to include systems design optimization.

Optimal cure cycle design of a resin-fiber composite laminate

NASA Technical Reports Server (NTRS)

Hou, Jean W.; Sheen, Jeenson

1987-01-01

A unified computed aided design method was studied for the cure cycle design that incorporates an optimal design technique with the analytical model of a composite cure process. The preliminary results of using this proposed method for optimal cure cycle design are reported and discussed. The cure process of interest is the compression molding of a polyester which is described by a diffusion reaction system. The finite element method is employed to convert the initial boundary value problem into a set of first order differential equations which are solved simultaneously by the DE program. The equations for thermal design sensitivities are derived by using the direct differentiation method and are solved by the DE program. A recursive quadratic programming algorithm with an active set strategy called a linearization method is used to optimally design the cure cycle, subjected to the given design performance requirements. The difficulty of casting the cure cycle design process into a proper mathematical form is recognized. Various optimal design problems are formulated to address theses aspects. The optimal solutions of these formulations are compared and discussed.

Preliminary Work for Examining the Scalability of Reinforcement Learning

NASA Technical Reports Server (NTRS)

Clouse, Jeff

1998-01-01

Researchers began studying automated agents that learn to perform multiple-step tasks early in the history of artificial intelligence (Samuel, 1963; Samuel, 1967; Waterman, 1970; Fikes, Hart & Nilsonn, 1972). Multiple-step tasks are tasks that can only be solved via a sequence of decisions, such as control problems, robotics problems, classic problem-solving, and game-playing. The objective of agents attempting to learn such tasks is to use the resources they have available in order to become more proficient at the tasks. In particular, each agent attempts to develop a good policy, a mapping from states to actions, that allows it to select actions that optimize a measure of its performance on the task; for example, reducing the number of steps necessary to complete the task successfully. Our study focuses on reinforcement learning, a set of learning techniques where the learner performs trial-and-error experiments in the task and adapts its policy based on the outcome of those experiments. Much of the work in reinforcement learning has focused on a particular, simple representation, where every problem state is represented explicitly in a table, and associated with each state are the actions that can be chosen in that state. A major advantage of this table lookup representation is that one can prove that certain reinforcement learning techniques will develop an optimal policy for the current task. The drawback is that the representation limits the application of reinforcement learning to multiple-step tasks with relatively small state-spaces. There has been a little theoretical work that proves that convergence to optimal solutions can be obtained when using generalization structures, but the structures are quite simple. The theory says little about complex structures, such as multi-layer, feedforward artificial neural networks (Rumelhart & McClelland, 1986), but empirical results indicate that the use of reinforcement learning with such structures is promising. These empirical results make no theoretical claims, nor compare the policies produced to optimal policies. A goal of our work is to be able to make the comparison between an optimal policy and one stored in an artificial neural network. A difficulty of performing such a study is finding a multiple-step task that is small enough that one can find an optimal policy using table lookup, yet large enough that, for practical purposes, an artificial neural network is really required. We have identified a limited form of the game OTHELLO as satisfying these requirements. The work we report here is in the very preliminary stages of research, but this paper provides background for the problem being studied and a description of our initial approach to examining the problem. In the remainder of this paper, we first describe reinforcement learning in more detail. Next, we present the game OTHELLO. Finally we argue that a restricted form of the game meets the requirements of our study, and describe our preliminary approach to finding an optimal solution to the problem.

New lab-made coagulant based on Schinopsis balansae tannin extract: synthesis optimization and preliminary tests on refractory water pollutants

NASA Astrophysics Data System (ADS)

Sánchez-Martín, J.; Beltrán-Heredia, J.; Coco-Rivero, B.

2014-09-01

Quebracho colorado tannin extract was used as a coagulant raw material for water and wastewater treatment. The chemical synthesis follows a Mannich reaction mechanism and provides a fully working coagulant that can remove several pollutants from water. This paper addresses the optimization of such synthesis and confirms the feasibility of the coagulant by testing it in a preliminary screening for the elimination of dyes and detergents. The optimum combination of reagents was 6.81 g of diethanolamine (DEA) and 2.78 g of formaldehyde (F) per g of tannin extract. So obtained coagulant was succesfully tested on the removal of 9 dyes and 8 detergents.

A preliminary design of the Ti:LiNbO3 optical channel waveguide

NASA Astrophysics Data System (ADS)

Choi, Yat

1992-03-01

One of the goals of technology-based activities within the Electronic Warfare Division is to facilitate the development within Australia, of facilities and a capability to manufacture sophisticated, highspeed electro-optic devices, in particular, the integrated optical amplitude modulator and integrated optical switch, for use in microwave and millimetre-wave systems for the Australian Defense Force (ADF). An initial step towards this goal would be to produce a low-loss and single-mode propagation optical channel waveguide using titanium-indiffused lithium niobate (Ti:LiNbO3). As no dimensions and fabrication parameters have yet been optimized, this technical report provides preliminary design data which optimizes these parameters.

Preliminary assessment of the ATHENA/WFI non-X-ray background

NASA Astrophysics Data System (ADS)

Perinati, Emanuele; Barbera, Marco; Diebold, Sebastian; Guzman, Alejandro; Santangelo, Andrea; Tenzer, Chris

2017-12-01

We present a preliminary assessment of the non-X-ray background for the WFI on board ATHENA conducted at IAAT in the context of the collaborative background and radiation damage working group activities. Our main result is that in the baseline configuration originally assumed for the camera the requirement on the level of non-X-ray background could not be met. In light of the results of Geant4 simulations we propose and discuss a possible optimization of the camera design and pinpoint some open issues to be addressed in the next phase of investigation. One of these concerns the possible contribution to the non-X-ray background from soft protons and ions funneled to the focal plane through the optics. This is not quantified at this stage, here we just briefly report on our ongoing activities aimed at validating the mechanisms of proton scattering at grazing incidence.

Healing of the canoe: preliminary results of a culturally tailored intervention to prevent substance abuse and promote tribal identity for Native youth in two Pacific Northwest tribes.

PubMed

Donovan, Dennis M; Thomas, Lisa Rey; Sigo, Robin Little Wing; Price, Laura; Lonczak, Heather; Lawrence, Nigel; Ahvakana, Katie; Austin, Lisette; Lawrence, Albie; Price, Joseph; Purser, Abby; Bagley, Lenora

2015-01-01

Using Community-based and Tribal Participatory Research (CBPR/TPR) approaches, an academic-tribal partnership between the University of Washington Alcohol and Drug Abuse Institute and the Suquamish and Port Gamble S'Klallam Tribes developed a culturally grounded social skills intervention to promote increased cultural belonging and prevent substance abuse among tribal youth. Participation in the intervention, which used the Canoe Journey as a metaphor for life, was associated with increased hope, optimism, and self-efficacy and with reduced substance use, as well as with higher levels of cultural identity and knowledge about alcohol and drugs among high school-age tribal youth. These results provide preliminary support for the intervention curricula in promoting positive youth development, an optimistic future orientation, and the reduction of substance use among Native youth.

HEALING OF THE CANOE: PRELIMINARY RESULTS OF A CULTURALLY GROUNDED INTERVENTION TO PREVENT SUBSTANCE ABUSE AND PROMOTE TRIBAL IDENTITY FOR NATIVE YOUTH IN TWO PACIFIC NORTHWEST TRIBE

PubMed Central

Donovan, Dennis M.; Thomas, Lisa Rey; Sigo, Robin Little Wing; Price, Laura; Lonczak, Heather; Lawrence, Nigel; Ahvakana, Katie; Austin, Lisette; Lawrence, Albie; Price, Joseph; Purser, Abby; Bagley, Lenora

2015-01-01

Using Community-Based and tribal Participatory Research (CBPR/TPR) approaches, an academic-tribal partnership between the University of Washington Alcohol and Drug Abuse Institute and the Suquamish and Port Gamble S’Klallam Tribes developed a culturally grounded social skills intervention to promote increased cultural belonging and prevent substance abuse among tribal youth. Participation in the intervention, which used the Canoe Journey as a metaphor for life, was associated with increased hope, optimism, and self-efficacy and with reduced substance use, as well as with higher levels of cultural identity and knowledge about alcohol and drugs among high school-age tribal youth. These results provide preliminary support for the intervention curricula in promoting positive youth development, an optimistic future orientation, and the reduction of substance use among Native youth. PMID:25768390

Status of ADRIANO R&D in T1015 Collaboration

DOE PAGES

Gatto, Corrado; Di Benedetto, V.; Mazzacane, A.

2015-02-13

The physics program for future High Energy and High Intensity experiments requires an energy resolution of the calorimetric component of detectors at limits of traditional techniques and an excellent particle identification. The novel ADRIANO technology (A Dualreadout Integrally Active Non-segmented Option), currently under development at Fermilab, is showing excellent performance on those respects. Results from detailed Monte Carlo studies on the performance with respect to energy resolution, linear response and transverse containment and a preliminary optimization of the layout are presented. A baseline configuration is chosen with an estimated energy resolution of σ(E)/E ≈ 30%/√E , to support an extensivemore » R&D program recently started by T1015 Collaboration at Fermilab. Furthermore, preliminary results from several test beams at the Fermilab Test Beam Facility (FTBF) of a ~ 1λI prototype are presented. Future prospects with ultra-heavy glass are, also, summarized.« less

Reliability Analysis and Reliability-Based Design Optimization of Circular Composite Cylinders Under Axial Compression

NASA Technical Reports Server (NTRS)

Rais-Rohani, Masoud

2001-01-01

This report describes the preliminary results of an investigation on component reliability analysis and reliability-based design optimization of thin-walled circular composite cylinders with average diameter and average length of 15 inches. Structural reliability is based on axial buckling strength of the cylinder. Both Monte Carlo simulation and First Order Reliability Method are considered for reliability analysis with the latter incorporated into the reliability-based structural optimization problem. To improve the efficiency of reliability sensitivity analysis and design optimization solution, the buckling strength of the cylinder is estimated using a second-order response surface model. The sensitivity of the reliability index with respect to the mean and standard deviation of each random variable is calculated and compared. The reliability index is found to be extremely sensitive to the applied load and elastic modulus of the material in the fiber direction. The cylinder diameter was found to have the third highest impact on the reliability index. Also the uncertainty in the applied load, captured by examining different values for its coefficient of variation, is found to have a large influence on cylinder reliability. The optimization problem for minimum weight is solved subject to a design constraint on element reliability index. The methodology, solution procedure and optimization results are included in this report.

Preliminary design report: Babcock and Wilcox BR-100 100-ton rail/barge spent fuel shipping cask

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1990-02-01

The purpose of this document is to provide information on burnup credit as applied to the preliminary design of the BR-100 shipping cask. There is a brief description of the preliminary basket design and the features used to maintain a critically safe system. Following the basket description is a discussion of various criticality analyses used to evaluate burnup credit. The results from these analyses are then reviewed in the perspective of fuel burnups expected to be shipped to either the final repository or a Monitored Retrievable Storage (MRS) facility. The hurdles to employing burnup credit in the certification of anymore » cask are then outlines and reviewed. the last section gives conclusions reached as to burnup credit for the BR-100 cask, based on our analyses and experience. All information in this study refers to the cask configured to transport PWR fuel. Boiling Water Reactor (BWR) fuel satisfies the criticality requirements so that burnup credit is not needed. All calculations generated in the preparation of this report were based upon the preliminary design which will be optimized during the final design. 8 refs., 19 figs., 16 tabs.« less

Optimization of a Biometric System Based on Acoustic Images

PubMed Central

Izquierdo Fuente, Alberto; Del Val Puente, Lara; Villacorta Calvo, Juan J.; Raboso Mateos, Mariano

2014-01-01

On the basis of an acoustic biometric system that captures 16 acoustic images of a person for 4 frequencies and 4 positions, a study was carried out to improve the performance of the system. On a first stage, an analysis to determine which images provide more information to the system was carried out showing that a set of 12 images allows the system to obtain results that are equivalent to using all of the 16 images. Finally, optimization techniques were used to obtain the set of weights associated with each acoustic image that maximizes the performance of the biometric system. These results improve significantly the performance of the preliminary system, while reducing the time of acquisition and computational burden, since the number of acoustic images was reduced. PMID:24616643

Remote sensing for industrial applications in the energy business: digital territorial data integration for planning of overhead power transmission lines (OHTLs)

NASA Astrophysics Data System (ADS)

Terrazzino, Alfonso; Volponi, Silvia; Borgogno Mondino, Enrico

2001-12-01

An investigation has been carried out, concerning remote sensing techniques, in order to assess their potential application to the energy system business: the most interesting results concern a new approach, based on digital data from remote sensing, to infrastructures with a large territorial distribution: in particular OverHead Transmission Lines, for the high voltage transmission and distribution of electricity on large distances. Remote sensing could in principle be applied to all the phases of the system lifetime, from planning to design, to construction, management, monitoring and maintenance. In this article, a remote sensing based approach is presented, targeted to the line planning: optimization of OHTLs path and layout, according to different parameters (technical, environmental and industrial). Planning new OHTLs is of particular interest in emerging markets, where typically the cartography is missing or available only on low accuracy scale (1:50.000 and lower), often not updated. Multi- spectral images can be used to generate thematic maps of the region of interest for the planning (soil coverage). Digital Elevation Models (DEMs), allow the planners to easily access the morphologic information of the surface. Other auxiliary information from local laws, environmental instances, international (IEC) standards can be integrated in order to perform an accurate optimized path choice and preliminary spotting of the OHTLs. This operation is carried out by an ABB proprietary optimization algorithm: the output is a preliminary path that bests fits the optimization parameters of the line in a life cycle approach.

Object-Oriented MDAO Tool with Aeroservoelastic Model Tuning Capability

NASA Technical Reports Server (NTRS)

Pak, Chan-gi; Li, Wesley; Lung, Shun-fat

2008-01-01

An object-oriented multi-disciplinary analysis and optimization (MDAO) tool has been developed at the NASA Dryden Flight Research Center to automate the design and analysis process and leverage existing commercial as well as in-house codes to enable true multidisciplinary optimization in the preliminary design stage of subsonic, transonic, supersonic and hypersonic aircraft. Once the structural analysis discipline is finalized and integrated completely into the MDAO process, other disciplines such as aerodynamics and flight controls will be integrated as well. Simple and efficient model tuning capabilities based on optimization problem are successfully integrated with the MDAO tool. More synchronized all phases of experimental testing (ground and flight), analytical model updating, high-fidelity simulations for model validation, and integrated design may result in reduction of uncertainties in the aeroservoelastic model and increase the flight safety.

Poly ɛ-caprolactone nanoparticles loaded with Uncaria tomentosa extract: preparation, characterization, and optimization using the Box-Behnken design.

PubMed

Ribeiro, Ana Ferreira; de Oliveira Rezende, Ricardo Leite; Cabral, Lúcio Mendes; de Sousa, Valéria Pereira

2013-01-01

The aim of this research was to develop and optimize a process for obtaining poly ɛ-caprolactone (PCL) nanoparticles loaded with Uncaria tomentosa (UT) extract. Nanoparticles were produced by the oil-in-water emulsion solvent evaporation method. Preliminary experiments determined the initial conditions of the organic phase (OP) and of the aqueous phase (AP) that would be utilized for this study. Ultimately, a three-factor three-level Box-Behnken design (BBD) was employed during the optimization process. PCL and polyvinyl alcohol (PVA) concentrations (X(1) and X(2), respectively) and the AP/OP volume ratio (X(3)) were the independent variables studied, while entrapment efficiency (Y(1)), particle mean diameter (Y(2)), polydispersity (Y(3)), and zeta potential (Y(4)) served as the evaluated responses. PRELIMINARY EXPERIMENTS REVEALED THAT THE OPTIMAL INITIAL CONDITIONS FOR THE PREPARATION OF NANOPARTICLES WERE AS FOLLOWS: OP composed of 5 mL ethyl acetate/acetone (3/2) mixture containing UT extract and PCL, and an AP of buffered PVA (pH 7.5) solution. Statistical analysis of the BBD results indicated that all of the studied factors had significant effects on the responses Y(1), Y(2), and Y(4,) and these effects are closely described or fitted by regression equations. Based on the obtained models and the selected desirability function, the nanoparticles were optimized to maximize Y(1) and minimize Y(2). These optimal conditions were achieved using 3% (w/v) PCL, 1% (w/v) PVA, and an AP/OP ratio of 1.7, with predicted values of 89.1% for Y(1) and 280 nm for Y(2). Another batch was produced under the same optimal conditions. The entrapment efficiency of this new batch was measured at 81.6% (Y(1)) and the particles had a mean size of 247 nm (Y(2)) and a polydispersity index of 0.062 (Y(3)). This investigation obtained UT-loaded nanoparticle formulations with desired characteristics. The BBD approach was a useful tool for nanoparticle development and optimization, and thus should be useful especially in the realm of phytotherapeutics, in which varied compositions may be assessed in quantitative and qualitative terms.

Optimization of the blade trailing edge geometric parameters for a small scale ORC turbine

NASA Astrophysics Data System (ADS)

Zhang, L.; Zhuge, W. L.; Peng, J.; Liu, S. J.; Zhang, Y. J.

2013-12-01

In general, the method proposed by Whitfield and Baines is adopted for the turbine preliminary design. In this design procedure for the turbine blade trailing edge geometry, two assumptions (ideal gas and zero discharge swirl) and two experience values (WR and γ) are used to get the three blade trailing edge geometric parameters: relative exit flow angle β6, the exit tip radius R6t and hub radius R6h for the purpose of maximizing the rotor total-to-static isentropic efficiency. The method above is established based on the experience and results of testing using air as working fluid, so it does not provide a mathematical optimal solution to instruct the optimization of geometry parameters and consider the real gas effects of the organic, working fluid which must be taken into consideration for the ORC turbine design procedure. In this paper, a new preliminary design and optimization method is established for the purpose of reducing the exit kinetic energy loss to improve the turbine efficiency ηts, and the blade trailing edge geometric parameters for a small scale ORC turbine with working fluid R123 are optimized based on this method. The mathematical optimal solution to minimize the exit kinetic energy is deduced, which can be used to design and optimize the exit shroud/hub radius and exit blade angle. And then, the influence of blade trailing edge geometric parameters on turbine efficiency ηts are analysed and the optimal working ranges of these parameters for the equations are recommended in consideration of working fluid R123. This method is used to modify an existing ORC turbine exit kinetic energy loss from 11.7% to 7%, which indicates the effectiveness of the method. However, the internal passage loss increases from 7.9% to 9.4%, so the only way to consider the influence of geometric parameters on internal passage loss is to give the empirical ranges of these parameters, such as the recommended ranges that the value of γ is at 0.3 to 0.4, and the value of τ is at 0.5 to 0.6.

Classical Optimal Control for Energy Minimization Based On Diffeomorphic Modulation under Observable-Response-Preserving Homotopy.

PubMed

Soley, Micheline B; Markmann, Andreas; Batista, Victor S

2018-06-12

We introduce the so-called "Classical Optimal Control Optimization" (COCO) method for global energy minimization based on the implementation of the diffeomorphic modulation under observable-response-preserving homotopy (DMORPH) gradient algorithm. A probe particle with time-dependent mass m( t;β) and dipole μ( r, t;β) is evolved classically on the potential energy surface V( r) coupled to an electric field E( t;β), as described by the time-dependent density of states represented on a grid, or otherwise as a linear combination of Gaussians generated by the k-means clustering algorithm. Control parameters β defining m( t;β), μ( r, t;β), and E( t;β) are optimized by following the gradients of the energy with respect to β, adapting them to steer the particle toward the global minimum energy configuration. We find that the resulting COCO algorithm is capable of resolving near-degenerate states separated by large energy barriers and successfully locates the global minima of golf potentials on flat and rugged surfaces, previously explored for testing quantum annealing methodologies and the quantum optimal control optimization (QuOCO) method. Preliminary results show successful energy minimization of multidimensional Lennard-Jones clusters. Beyond the analysis of energy minimization in the specific model systems investigated, we anticipate COCO should be valuable for solving minimization problems in general, including optimization of parameters in applications to machine learning and molecular structure determination.

PREPARATION AND PROPERTIES OF COMPOUND ARNEBIAE RADIX MICROEMULSION GEL

PubMed Central

Chen, Jing; He, Yanping; Gao, Ting; Zhang, Licheng; Zhao, Yuna

2017-01-01

Background: Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound Arnebiae radix microemulsion gel for transdermal delivery system and evaluate its characteristics. Materials and Methods: Based on the solubility of Shikonin, the active component of Arnebiae radix and the results of phase studies, adequate ratio of each component in microemulsion was determined. The optimized microemulsion gel was prepared using Carbomer 940. The gels were characterized in terms of appearance, preliminary stability test and the content of Shikonin in the compound Arnebiae radix microemulsion gel with HPLC analysis. Results: The optimized conditions for preparing microemulsion were Tween-80, glycerin, isopropyl myristate (IPM) with the ratio of 6:3:2. The optimal microemulsion gel was obtained with Carbomer 940 (1.0%). Conclusion: The prepared compound Arnebiae radix microemulsion gel showed good stability over time. It is more convenience in application than the previous used formulations. PMID:28480438

Towards a Quantum Dynamical Study of the H_2O+H_2O Inelastic Collision: Representation of the Potential and Preliminary Results

NASA Astrophysics Data System (ADS)

Ndengue, Steve Alexandre; Dawes, Richard

2017-06-01

Water, an essential ingredient of life, is prevalent in space and various media. H_2O in the gas phase is the major polyatomic species in the interstellar medium (ISM) and a primary target of current studies of collisional dynamics. In recent years a number of theoretical and experimental studies have been devoted to H_2O-X (with X=He, H_2, D_2, Ar, ?) elastic and inelastic collisions in an effort to understand rotational distributions of H_2O in molecular clouds. Although those studies treated several abundant species, no quantum mechanical calculation has been reported to date for a nonlinear polyatomic collider. We present in this talk the preliminary steps toward this goal, using the H_2O molecule itself as our collider, the very accurate MB-Pol surface to describe the intermolecular interaction and the MultiConfiguration Time Dependent (MCTDH) algorithm to study the dynamics. One main challenge in this effort is the need to express the Potential Energy Surface (PES) in a sum-of-products form optimal for MCTDH calculations. We will describe how this was done and present preliminary results of state-to-state probabilities.

Human Performance on Hard Non-Euclidean Graph Problems: Vertex Cover

ERIC Educational Resources Information Center

Carruthers, Sarah; Masson, Michael E. J.; Stege, Ulrike

2012-01-01

Recent studies on a computationally hard visual optimization problem, the Traveling Salesperson Problem (TSP), indicate that humans are capable of finding close to optimal solutions in near-linear time. The current study is a preliminary step in investigating human performance on another hard problem, the Minimum Vertex Cover Problem, in which…

Conjugate gradient determination of optimal plane changes for a class of three-impulse transfers between noncoplanar circular orbits

NASA Technical Reports Server (NTRS)

Burrows, R. R.

1972-01-01

A particular type of three-impulse transfer between two circular orbits is analyzed. The possibility of three plane changes is recognized, and the problem is to optimally distribute these plane changes to minimize the sum of the individual impulses. Numerical difficulties and their solution are discussed. Numerical results obtained from a conjugate gradient technique are presented for both the case where the individual plane changes are unconstrained and for the case where they are constrained. Possibly not unexpectedly, multiple minima are found. The techniques presented could be extended to the finite burn case, but primarily the contents are addressed to preliminary mission design and vehicle sizing.

Automating Initial Guess Generation for High Fidelity Trajectory Optimization Tools

NASA Technical Reports Server (NTRS)

Villa, Benjamin; Lantoine, Gregory; Sims, Jon; Whiffen, Gregory

2013-01-01

Many academic studies in spaceflight dynamics rely on simplified dynamical models, such as restricted three-body models or averaged forms of the equations of motion of an orbiter. In practice, the end result of these preliminary orbit studies needs to be transformed into more realistic models, in particular to generate good initial guesses for high-fidelity trajectory optimization tools like Mystic. This paper reviews and extends some of the approaches used in the literature to perform such a task, and explores the inherent trade-offs of such a transformation with a view toward automating it for the case of ballistic arcs. Sample test cases in the libration point regimes and small body orbiter transfers are presented.

Study on Process Parameters of Extraction of γ-aminobutyric Acid Instant Moringa oleifera Powder

NASA Astrophysics Data System (ADS)

Tiaokun, Fu; Suhui, Zhang; Neng, Liu; Jihua, Li; Shaodan, Peng; Changqing, Guo; Wei, Zhou

2017-12-01

To preliminary optimize the extraction of γ-aminobutyric acid instant tea powder from Moringa oleifera leaves,taking γ-aminobutyric acid Moringa oleifera leaves as raw material and pure water as extraction solvent and GABA content as the main evaluation index,the effects of extraction temperature, ratio of liquid to material and extraction time on biochemical components and sensory qualities of Moringa oleifera leaves extractor was studied by using one-factor-at-a-time experiment.The results showed shat the optimal extraction conditions for γ-aminobutyric acid instant tea powder were extraction temperature of 60 °C, material-to-water ration of 1:10 and extraction time of 40 min.

Trajectories for High Specific Impulse High Specific Power Deep Space Exploration

NASA Technical Reports Server (NTRS)

Polsgrove, T.; Adams, R. B.; Brady, Hugh J. (Technical Monitor)

2002-01-01

Preliminary results are presented for two methods to approximate the mission performance of high specific impulse high specific power vehicles. The first method is based on an analytical approximation derived by Williams and Shepherd and can be used to approximate mission performance to outer planets and interstellar space. The second method is based on a parametric analysis of trajectories created using the well known trajectory optimization code, VARITOP. This parametric analysis allows the reader to approximate payload ratios and optimal power requirements for both one-way and round-trip missions. While this second method only addresses missions to and from Jupiter, future work will encompass all of the outer planet destinations and some interstellar precursor missions.

Endoscopic Carbon Dioxide Laser Photocoagulation Of Bleeding Canine Gastric Ulcers

NASA Astrophysics Data System (ADS)

Gal, Dov; Ron, Nimrod; Orgad, Uri; Katzir, Abraham

1987-04-01

This is the first report which describes carbon dioxide laser photocoagulation of upper gastrointestinal bleeding via a flexible endoscope, using an infrared transmitting siver nalide fiber. Various laser parameters were checked to determine the optimal conditions for hemostasis. Both the acute effects of laser irradiation on tissue and the chronic effects on healing process were examined. Preliminary results indicate that carbon dioxide laser beam can successfully photocoagulate moderately bleeding ulcers.

A persuasive toothbrush to enhance oral hygiene adherence.

PubMed

Walji, Muhammad F; Coker, Ololade; Valenza, John A; Henson, Harold; Warren-Morris, Donna; Zhong, Lin

2008-11-06

In this research we propose that a real-time wireless monitoring and reminder system can assist patients in maintaining optimal oral health. We provide a conceptual framework that incorporates both the behavioral and technical aspects of the proposed system. Further we present preliminary results of a feasibility experiment of modifying an inexpensive electric toothbrush by attaching an accelerometer and determining the ability to track motion and time by wirelessly transmitting data via Bluetooth technology.

Solving large-scale fixed cost integer linear programming models for grid-based location problems with heuristic techniques

NASA Astrophysics Data System (ADS)

Noor-E-Alam, Md.; Doucette, John

2015-08-01

Grid-based location problems (GBLPs) can be used to solve location problems in business, engineering, resource exploitation, and even in the field of medical sciences. To solve these decision problems, an integer linear programming (ILP) model is designed and developed to provide the optimal solution for GBLPs considering fixed cost criteria. Preliminary results show that the ILP model is efficient in solving small to moderate-sized problems. However, this ILP model becomes intractable in solving large-scale instances. Therefore, a decomposition heuristic is proposed to solve these large-scale GBLPs, which demonstrates significant reduction of solution runtimes. To benchmark the proposed heuristic, results are compared with the exact solution via ILP. The experimental results show that the proposed method significantly outperforms the exact method in runtime with minimal (and in most cases, no) loss of optimality.

DMS cyclone separation processes for optimization of plastic wastes recycling and their implications.

PubMed

Gent, Malcolm Richard; Menendez, Mario; Toraño, Javier; Torno, Susana

2011-06-01

It is demonstrated that substantial reductions in plastics presently disposed of in landfills can be achieved by cyclone density media separation (DMS). In comparison with the size fraction of plastics presently processed by industrial density separations (generally 6.4 to 9.5 mm), cyclone DMS methods are demonstrated to effectively process a substantially greater range of particle sizes (from 0.5 up to 120 mm). The purities of plastic products and recoveries obtained with a single stage separation using a cylindrical cyclone are shown to attain virtually 100% purity and recoveries >99% for high-density fractions and >98% purity and recoveries were obtained for low-density products. Four alternative schemas of multi-stage separations are presented and analyzed as proposed methods to obtain total low- and high-density plastics fraction recoveries while maintaining near 100% purities. The results of preliminary tests of two of these show that the potential for processing product purities and recoveries >99.98% of both density fractions are indicated. A preliminary economic comparison of capital costs of DMS systems suggests cyclone DMS methods to be comparable with other DMS processes even if the high volume capacity for recycling operations of these is not optimized.

Optimization for ultrasonic-microwave synergistic extraction of polysaccharides from Cornus officinalis and characterization of polysaccharides.

PubMed

Yin, Xiulian; You, Qinghong; Jiang, Zhonghai; Zhou, Xinghai

2016-02-01

Ultrasonic-microwave synergistic extraction (UMSE) of polysaccharides from Cornus officinalis was optimized by response surface methodology (RSM). The effect of four different factors on the yield of C. officinalis polysaccharides (COP) was studied. RSM results showed that the optimal conditions were extraction time of 31.49823 min, microwave power of 99.39769 W, and water-to-raw material ratio of 28.16273. The COP yield was 11.38±0.31% using the modified optimal conditions, which was consistent with the value predicted by the model. The crude COP was purified by DEAE-Cellulose 52 chromatography and Sephadex G-100 chromatography. Five fractions, namely, crude COP, COP-1, COP-2, COP-3, and COP-4, were obtained. Monosaccharide composition analysis revealed that the COP was composed of glucose, arabinose, fucose, xylose, mannose, and rhamnose. Preliminary structural characterizations of COP were conducted by scanning electron microscopy and Fourier transform infrared spectroscopy. Copyright © 2015 Elsevier B.V. All rights reserved.

Digi Island: A Serious Game for Teaching and Learning Digital Circuit Optimization

NASA Technical Reports Server (NTRS)

Harper, Michael; Miller, Joseph; Shen, Yuzhong

2011-01-01

Karnaugh maps, also known as K-maps, are a tool used to optimize or simplify digital logic circuits. A K-map is a graphical display of a logic circuit. K-map optimization is essentially the process of finding a minimum number of maximal aggregations of K-map cells. with values of 1 according to a set of rules. The Digi Island is a serious game designed for aiding students to learn K-map optimization. The game takes place on an exotic island (called Digi Island) in the Pacific Ocean . The player is an adventurer to the Digi Island and will transform it into a tourist attraction by developing real estates, such as amusement parks.and hotels. The Digi Island game elegantly converts boring 1s and Os in digital circuits into usable and unusable spaces on a beautiful island and transforms K-map optimization into real estate development, an activity with which many students are familiar and also interested in. This paper discusses the design, development, and some preliminary results of the Digi Island game.

United States Air Force Graduate Student Research Program. Program Management Report

DTIC Science & Technology

1988-12-01

PRELIMINARY STRUCTURAL DESIGN/OPTIMIZATION by Richard A. Swift ABSTRACT Finite element analysis for use in structural design has advanced to the point where...Plates Subjected Gregory Schoeppner to Low Velocity Impact *** Same Report as Prof. William Wolfe * 57 Finite Element Analysis for Preliminary Richard...and dynamic load conditions using both radial and bias- ply tires. A detailed three-dimensional finite - element model of the wheel was generated for

Aero-Thermo-Structural Design Optimization of Internally Cooled Turbine Blades

NASA Technical Reports Server (NTRS)

Dulikravich, G. S.; Martin, T. J.; Dennis, B. H.; Lee, E.; Han, Z.-X.

1999-01-01

A set of robust and computationally affordable inverse shape design and automatic constrained optimization tools have been developed for the improved performance of internally cooled gas turbine blades. The design methods are applicable to the aerodynamics, heat transfer, and thermoelasticity aspects of the turbine blade. Maximum use of the existing proven disciplinary analysis codes is possible with this design approach. Preliminary computational results demonstrate possibilities to design blades with minimized total pressure loss and maximized aerodynamic loading. At the same time, these blades are capable of sustaining significantly higher inlet hot gas temperatures while requiring remarkably lower coolant mass flow rates. These results suggest that it is possible to design internally cooled turbine blades that will cost less to manufacture, will have longer life span, and will perform as good, if not better than, film cooled turbine blades.

Spatial Light Modulators and Applications. 1988 Technical Digest Series, Volume 8

DTIC Science & Technology

1988-06-01

presence of an applied field but without run- ning gratings; then the fringes are allowed to move, with a velocity that optimizes self- in which F0...Laboratories. The optimization of an MQW modulator for both phase and amplitude modulation is reported, along with preliminary structural N.J design for a...Canyon Road Malibu, California 90265 ABSTRACT The optimization of an MOW modulator for both phase and amplitude modulation is reported,along with

The preliminary SOL (Sizing and Optimization Language) reference manual

NASA Technical Reports Server (NTRS)

Lucas, Stephen H.; Scotti, Stephen J.

1989-01-01

The Sizing and Optimization Language, SOL, a high-level special-purpose computer language has been developed to expedite application of numerical optimization to design problems and to make the process less error-prone. This document is a reference manual for those wishing to write SOL programs. SOL is presently available for DEC VAX/VMS systems. A SOL package is available which includes the SOL compiler and runtime library routines. An overview of SOL appears in NASA TM 100565.

Provisional-Ideal-Point-Based Multi-objective Optimization Method for Drone Delivery Problem

NASA Astrophysics Data System (ADS)

Omagari, Hiroki; Higashino, Shin-Ichiro

2018-04-01

In this paper, we proposed a new evolutionary multi-objective optimization method for solving drone delivery problems (DDP). It can be formulated as a constrained multi-objective optimization problem. In our previous research, we proposed the "aspiration-point-based method" to solve multi-objective optimization problems. However, this method needs to calculate the optimal values of each objective function value in advance. Moreover, it does not consider the constraint conditions except for the objective functions. Therefore, it cannot apply to DDP which has many constraint conditions. To solve these issues, we proposed "provisional-ideal-point-based method." The proposed method defines a "penalty value" to search for feasible solutions. It also defines a new reference solution named "provisional-ideal point" to search for the preferred solution for a decision maker. In this way, we can eliminate the preliminary calculations and its limited application scope. The results of the benchmark test problems show that the proposed method can generate the preferred solution efficiently. The usefulness of the proposed method is also demonstrated by applying it to DDP. As a result, the delivery path when combining one drone and one truck drastically reduces the traveling distance and the delivery time compared with the case of using only one truck.

Overview: Applications of numerical optimization methods to helicopter design problems

NASA Technical Reports Server (NTRS)

Miura, H.

1984-01-01

There are a number of helicopter design problems that are well suited to applications of numerical design optimization techniques. Adequate implementation of this technology will provide high pay-offs. There are a number of numerical optimization programs available, and there are many excellent response/performance analysis programs developed or being developed. But integration of these programs in a form that is usable in the design phase should be recognized as important. It is also necessary to attract the attention of engineers engaged in the development of analysis capabilities and to make them aware that analysis capabilities are much more powerful if integrated into design oriented codes. Frequently, the shortcoming of analysis capabilities are revealed by coupling them with an optimization code. Most of the published work has addressed problems in preliminary system design, rotor system/blade design or airframe design. Very few published results were found in acoustics, aerodynamics and control system design. Currently major efforts are focused on vibration reduction, and aerodynamics/acoustics applications appear to be growing fast. The development of a computer program system to integrate the multiple disciplines required in helicopter design with numerical optimization technique is needed. Activities in Britain, Germany and Poland are identified, but no published results from France, Italy, the USSR or Japan were found.

Simultaneous Microwave Extraction and Separation of Volatile and Non-Volatile Organic Compounds of Boldo Leaves. From Lab to Industrial Scale

PubMed Central

Petigny, Loïc; Périno, Sandrine; Minuti, Matteo; Visinoni, Francesco; Wajsman, Joël; Chemat, Farid

2014-01-01

Microwave extraction and separation has been used to increase the concentration of the extract compared to the conventional method with the same solid/liquid ratio, reducing extraction time and separate at the same time Volatile Organic Compounds (VOC) from non-Volatile Organic Compounds (NVOC) of boldo leaves. As preliminary study, a response surface method has been used to optimize the extraction of soluble material and the separation of VOC from the plant in laboratory scale. The results from the statistical analysis revealed that the optimized conditions were: microwave power 200 W, extraction time 56 min and solid liquid ratio of 7.5% of plants in water. Lab scale optimized microwave method is compared to conventional distillation, and requires a power/mass ratio of 0.4 W/g of water engaged. This power/mass ratio is kept in order to upscale from lab to pilot plant. PMID:24776762

Advanced fast 3D DSA model development and calibration for design technology co-optimization

NASA Astrophysics Data System (ADS)

Lai, Kafai; Meliorisz, Balint; Muelders, Thomas; Welling, Ulrich; Stock, Hans-Jürgen; Marokkey, Sajan; Demmerle, Wolfgang; Liu, Chi-Chun; Chi, Cheng; Guo, Jing

2017-04-01

Direct Optimization (DO) of a 3D DSA model is a more optimal approach to a DTCO study in terms of accuracy and speed compared to a Cahn Hilliard Equation solver. DO's shorter run time (10X to 100X faster) and linear scaling makes it scalable to the area required for a DTCO study. However, the lack of temporal data output, as opposed to prior art, requires a new calibration method. The new method involves a specific set of calibration patterns. The calibration pattern's design is extremely important when temporal data is absent to obtain robust model parameters. A model calibrated to a Hybrid DSA system with a set of device-relevant constructs indicates the effectiveness of using nontemporal data. Preliminary model prediction using programmed defects on chemo-epitaxy shows encouraging results and agree qualitatively well with theoretical predictions from a strong segregation theory.

A Multiobjective Interval Programming Model for Wind-Hydrothermal Power System Dispatching Using 2-Step Optimization Algorithm

PubMed Central

Jihong, Qu

2014-01-01

Wind-hydrothermal power system dispatching has received intensive attention in recent years because it can help develop various reasonable plans to schedule the power generation efficiency. But future data such as wind power output and power load would not be accurately predicted and the nonlinear nature involved in the complex multiobjective scheduling model; therefore, to achieve accurate solution to such complex problem is a very difficult task. This paper presents an interval programming model with 2-step optimization algorithm to solve multiobjective dispatching. Initially, we represented the future data into interval numbers and simplified the object function to a linear programming problem to search the feasible and preliminary solutions to construct the Pareto set. Then the simulated annealing method was used to search the optimal solution of initial model. Thorough experimental results suggest that the proposed method performed reasonably well in terms of both operating efficiency and precision. PMID:24895663

A multiobjective interval programming model for wind-hydrothermal power system dispatching using 2-step optimization algorithm.

PubMed

Ren, Kun; Jihong, Qu

2014-01-01

Wind-hydrothermal power system dispatching has received intensive attention in recent years because it can help develop various reasonable plans to schedule the power generation efficiency. But future data such as wind power output and power load would not be accurately predicted and the nonlinear nature involved in the complex multiobjective scheduling model; therefore, to achieve accurate solution to such complex problem is a very difficult task. This paper presents an interval programming model with 2-step optimization algorithm to solve multiobjective dispatching. Initially, we represented the future data into interval numbers and simplified the object function to a linear programming problem to search the feasible and preliminary solutions to construct the Pareto set. Then the simulated annealing method was used to search the optimal solution of initial model. Thorough experimental results suggest that the proposed method performed reasonably well in terms of both operating efficiency and precision.

An intelligent emissions controller for fuel lean gas reburn in coal-fired power plants.

PubMed

Reifman, J; Feldman, E E; Wei, T Y; Glickert, R W

2000-02-01

The application of artificial intelligence techniques for performance optimization of the fuel lean gas reburn (FLGR) system is investigated. A multilayer, feedforward artificial neural network is applied to model static nonlinear relationships between the distribution of injected natural gas into the upper region of the furnace of a coal-fired boiler and the corresponding oxides of nitrogen (NOx) emissions exiting the furnace. Based on this model, optimal distributions of injected gas are determined such that the largest NOx reduction is achieved for each value of total injected gas. This optimization is accomplished through the development of a new optimization method based on neural networks. This new optimal control algorithm, which can be used as an alternative generic tool for solving multidimensional nonlinear constrained optimization problems, is described and its results are successfully validated against an off-the-shelf tool for solving mathematical programming problems. Encouraging results obtained using plant data from one of Commonwealth Edison's coal-fired electric power plants demonstrate the feasibility of the overall approach. Preliminary results show that the use of this intelligent controller will also enable the determination of the most cost-effective operating conditions of the FLGR system by considering, along with the optimal distribution of the injected gas, the cost differential between natural gas and coal and the open-market price of NOx emission credits. Further study, however, is necessary, including the construction of a more comprehensive database, needed to develop high-fidelity process models and to add carbon monoxide (CO) emissions to the model of the gas reburn system.

Microscopic Optical Characterization of Free Standing III-Nitride Substrates, ZnO Bulk Crystals, and III-V Structures for Non-Linear Optics. Part 2

DTIC Science & Technology

2010-05-18

strong radiation hardness of ZnO. Positron annihilation studies have revealed the presence of Zn vacancies under high energy electron irradiation, as...SUPPLEMENTARY NOTES 14. ABSTRACT CL study of ammonothermal GaN crystals. Preliminary results on ammonothermal AlGaN crystals show a clear...prevalence of deep level luminescence Study of the luminescence spectral characteristics. Optimization of the excitonic emission vs deep level emission

An integrated aerodynamic/propulsion study for generic aero-space planes based on waverider concepts

NASA Technical Reports Server (NTRS)

Rasmussen, M. L.; Emanuel, George

1989-01-01

The design of a unified aero-space plane based on waverider technology is analyzed. The overall aerodynamic design and performance of an aero-space plane are discussed in terms of the forebody, scramjet, and afterbody. Other subjects considered in the study are combustion/nozzle optimization, the idealized tip-to-tail waverider model, and the two-dimensional minimum length nozzle. Charts and graphs are provided to show the results of the preliminary investigations.

Platelet lysate mucohadesive formulation to treat oral mucositis in graft versus host disease patients: a new therapeutic approach.

PubMed

Del Fante, Claudia; Perotti, Cesare; Bonferoni, Maria Cristina; Rossi, Silvia; Sandri, Giuseppina; Ferrari, Franca; Scudeller, Luigia; Caramella, Carla Marcella

2011-09-01

Optimal treatment of oral mucositis (OM) due to graft versus host disease (GvHD) is currently not available. Platelet-derived growth factors (PDGFs) have high capability for tissue healing and may play a role in repairing the mucosal barrier. The aim of the present work was to develop a mucoadhesive formulation to administer platelet lysate to oral cavity prolonging contact time of platelet lysate with oral mucosa. The mucoadhesive formulation was characterized for in vitro properties (PDGF-AB concentration, mucoadhesive properties, cytotoxicity, fibroblast proliferation, wound healing). Moreover, a preliminary clinical study on seven GvHD patients with OM refractory to other therapies was conducted, to evaluate feasibility, safety, and efficacy. GVPL (mucoadhesive gel vehicle mixed with platelet lysate)showed good mucoadhesive properties; additionally, it was characterized by good biocompatibility in vitro on fibroblasts and it was able to enhance fibroblast proliferation and wound healing, maintaining the efficacy for up to 14 days following storage at 2-8°C. In vivo, clinical response was good-to-complete in five, fair in one, none in the remaining one. The in vitro results indicate that GVPL has optimal mucoadhesive and healing enhancer properties, maintained over time (up to 14 days); preliminary clinical results suggest that oral application of platelet lysate-loaded mucoadhesive formulation is feasible, safe, well tolerated, and effective. A larger controlled randomized study is needed.

Electro-optic fringe locking and photometric tuning using a two-stage Mach-Zehnder lithium niobate waveguide for high-contrast mid-infrared interferometry

NASA Astrophysics Data System (ADS)

Martin, Guillermo; Heidmann, Samuel; Rauch, Jean-Yves; Jocou, Laurent; Courjal, Nadège

2014-03-01

We present an optimization process to improve the rejection ratio in integrated beam combiners by locking the dark fringe and then monitoring its intensity. The method proposed here uses the electro-optic effect of lithium niobate in order to lock the dark fringe and to real-time balance the photometric flux by means of a two-stage Mach-Zehnder interferometer waveguide. By applying a control voltage on the output Y-junction, we are able to lock the phase and stay in the dark fringe, while an independent second voltage is applied on the first-stage intensity modulator, to finely balance the photometries. We have obtained a rejection ratio of 4600 (36.6 dB) at 3.39 μm in transverse electric polarization, corresponding to 99.98% fringe contrast, and shown that the system can compensate external phase perturbations (a piston variation of 100 nm) up to around 1 kHz. We also show the preliminary results of this process on wide-band modulation, where a contrast of 38% in 3.25- to 3.65-μm spectral range is obtained. These preliminary results on wide-band need to be optimized, in particular, for reducing scattered light of the device at the Y-junction. We expect this active method to be useful in high-contrast interferometry, in particular, for astronomical spatial projects actually under study.

Nontangent, Developed Contour Bulkheads for a Single-Stage Launch Vehicle

NASA Technical Reports Server (NTRS)

Wu, K. Chauncey; Lepsch, Roger A., Jr.

2000-01-01

Dry weights for single-stage launch vehicles that incorporate nontangent, developed contour bulkheads are estimated and compared to a baseline vehicle with 1.414 aspect ratio ellipsoidal bulkheads. Weights, volumes, and heights of optimized bulkhead designs are computed using a preliminary design bulkhead analysis code. The dry weights of vehicles that incorporate the optimized bulkheads are predicted using a vehicle weights and sizing code. Two optimization approaches are employed. A structural-level method, where the vehicle's three major bulkhead regions are optimized separately and then incorporated into a model for computation of the vehicle dry weight, predicts a reduction of4365 lb (2.2 %) from the 200,679-lb baseline vehicle dry weight. In the second, vehicle-level, approach, the vehicle dry weight is the objective function for the optimization. For the vehicle-level analysis, modified bulkhead designs are analyzed and incorporated into the weights model for computation of a dry weight. The optimizer simultaneously manipulates design variables for all three bulkheads to reduce the dry weight. The vehicle-level analysis predicts a dry weight reduction of 5129 lb, a 2.6% reduction from the baseline weight. Based on these results, nontangent, developed contour bulkheads may provide substantial weight savings for single stage vehicles.

Applications of wavelet-based compression to multidimensional Earth science data

NASA Technical Reports Server (NTRS)

Bradley, Jonathan N.; Brislawn, Christopher M.

1993-01-01

A data compression algorithm involving vector quantization (VQ) and the discrete wavelet transform (DWT) is applied to two different types of multidimensional digital earth-science data. The algorithms (WVQ) is optimized for each particular application through an optimization procedure that assigns VQ parameters to the wavelet transform subbands subject to constraints on compression ratio and encoding complexity. Preliminary results of compressing global ocean model data generated on a Thinking Machines CM-200 supercomputer are presented. The WVQ scheme is used in both a predictive and nonpredictive mode. Parameters generated by the optimization algorithm are reported, as are signal-to-noise (SNR) measurements of actual quantized data. The problem of extrapolating hydrodynamic variables across the continental landmasses in order to compute the DWT on a rectangular grid is discussed. Results are also presented for compressing Landsat TM 7-band data using the WVQ scheme. The formulation of the optimization problem is presented along with SNR measurements of actual quantized data. Postprocessing applications are considered in which the seven spectral bands are clustered into 256 clusters using a k-means algorithm and analyzed using the Los Alamos multispectral data analysis program, SPECTRUM, both before and after being compressed using the WVQ program.

Co-state initialization for the minimum-time low-thrust trajectory optimization

NASA Astrophysics Data System (ADS)

Taheri, Ehsan; Li, Nan I.; Kolmanovsky, Ilya

2017-05-01

This paper presents an approach for co-state initialization which is a critical step in solving minimum-time low-thrust trajectory optimization problems using indirect optimal control numerical methods. Indirect methods used in determining the optimal space trajectories typically result in two-point boundary-value problems and are solved by single- or multiple-shooting numerical methods. Accurate initialization of the co-state variables facilitates the numerical convergence of iterative boundary value problem solvers. In this paper, we propose a method which exploits the trajectory generated by the so-called pseudo-equinoctial and three-dimensional finite Fourier series shape-based methods to estimate the initial values of the co-states. The performance of the approach for two interplanetary rendezvous missions from Earth to Mars and from Earth to asteroid Dionysus is compared against three other approaches which, respectively, exploit random initialization of co-states, adjoint-control transformation and a standard genetic algorithm. The results indicate that by using our proposed approach the percent of the converged cases is higher for trajectories with higher number of revolutions while the computation time is lower. These features are advantageous for broad trajectory search in the preliminary phase of mission designs.

Optimization of helicopter airframe structures for vibration reduction considerations, formulations and applications

NASA Technical Reports Server (NTRS)

Murthy, T. Sreekanta

1988-01-01

Several key issues involved in the application of formal optimization technique to helicopter airframe structures for vibration reduction are addressed. Considerations which are important in the optimization of real airframe structures are discussed. Considerations necessary to establish relevant set of design variables, constraints and objectives which are appropriate to conceptual, preliminary, detailed design, ground and flight test phases of airframe design are discussed. A methodology is suggested for optimization of airframes in various phases of design. Optimization formulations that are unique to helicopter airframes are described and expressions for vibration related functions are derived. Using a recently developed computer code, the optimization of a Bell AH-1G helicopter airframe is demonstrated.

Preliminary control law and hardware designs for a ride quality augmentation system for commuter aircraft. Phase 2

NASA Technical Reports Server (NTRS)

Davis, D. J.; Linse, D. J.; Suikat, R.; Entz, D. P.

1986-01-01

The continued investigation of the design of Ride Quality Augmentation Systems (RQAS) for commuter aircraft is described. The purpose of these RQAS is the reduction of the vertical and lateral acceleration response of the aircraft due to atmospheric turbulence by the application of active control. The current investigations include the refinement of the sample data feedback control laws based on the control-rate-weighting and output-weighting optimal control design techniqes. These control designs were evaluated using aircraft time simulations driven by Dryden spectra turbulence. Fixed gain controllers were tested throughout the aircrft operating envelope. The preliminary design of the hardware modifications necessary to implement and test the RQAS on a commuter aircraft is included. These include a separate surface elevator and the flap modifications to provide both direct lift and roll control. A preliminary failure mode investigation was made for the proposed configuration. The results indicate that vertical acceleration reductions of 45% and lateral reductions of more than 50% are possible. A fixed gain controller appears to be feasible with only minor response degradation.

Quantum Heterogeneous Computing for Satellite Positioning Optimization

NASA Astrophysics Data System (ADS)

Bass, G.; Kumar, V.; Dulny, J., III

2016-12-01

Hard optimization problems occur in many fields of academic study and practical situations. We present results in which quantum heterogeneous computing is used to solve a real-world optimization problem: satellite positioning. Optimization problems like this can scale very rapidly with problem size, and become unsolvable with traditional brute-force methods. Typically, such problems have been approximately solved with heuristic approaches; however, these methods can take a long time to calculate and are not guaranteed to find optimal solutions. Quantum computing offers the possibility of producing significant speed-up and improved solution quality. There are now commercially available quantum annealing (QA) devices that are designed to solve difficult optimization problems. These devices have 1000+ quantum bits, but they have significant hardware size and connectivity limitations. We present a novel heterogeneous computing stack that combines QA and classical machine learning and allows the use of QA on problems larger than the quantum hardware could solve in isolation. We begin by analyzing the satellite positioning problem with a heuristic solver, the genetic algorithm. The classical computer's comparatively large available memory can explore the full problem space and converge to a solution relatively close to the true optimum. The QA device can then evolve directly to the optimal solution within this more limited space. Preliminary experiments, using the Quantum Monte Carlo (QMC) algorithm to simulate QA hardware, have produced promising results. Working with problem instances with known global minima, we find a solution within 8% in a matter of seconds, and within 5% in a few minutes. Future studies include replacing QMC with commercially available quantum hardware and exploring more problem sets and model parameters. Our results have important implications for how heterogeneous quantum computing can be used to solve difficult optimization problems in any field.

Indexed triangle strips optimization for real-time visualization using genetic algorithm: preliminary study

NASA Astrophysics Data System (ADS)

Tanaka, Kiyoshi; Takano, Shuichi; Sugimura, Tatsuo

2000-10-01

In this work we focus on the indexed triangle strips that is an extended representation of triangle strips to improve the efficiency for geometrical transformation of vertices, and present a method to construct optimum indexed triangle strips using Genetic Algorithm (GA) for real-time visualization. The main objective of this work is how to optimally construct indexed triangle strips by improving the ratio that reuses the data stored in the cash memory and simultaneously reducing the total index numbers with GA. Simulation results verify that the average index numbers and cache miss ratio per polygon cold be small, and consequently the total visualization time required for the optimum solution obtained by this scheme could be remarkably reduced.

MHD Code Optimizations and Jets in Dense Gaseous Halos

NASA Astrophysics Data System (ADS)

Gaibler, Volker; Vigelius, Matthias; Krause, Martin; Camenzind, Max

We have further optimized and extended the 3D-MHD-code NIRVANA. The magnetized part runs in parallel, reaching 19 Gflops per SX-6 node, and has a passively advected particle population. In addition, the code is MPI-parallel now - on top of the shared memory parallelization. On a 512^3 grid, we reach 561 Gflops with 32 nodes on the SX-8. Also, we have successfully used FLASH on the Opteron cluster. Scientific results are preliminary so far. We report one computation of highly resolved cocoon turbulence. While we find some similarities to earlier 2D work by us and others, we note a strange reluctancy of cold material to enter the low density cocoon, which has to be investigated further.

A modelling framework for mitigating customers' waiting time at a vehicle inspection centre

NASA Astrophysics Data System (ADS)

Ahmad, Norazura; Abidin, Norhaslinda Zainal; Ilyas, Khibtiyah; Abduljabbar, Waleed Khalid

2017-11-01

In Malaysia, an agency that is entrusted by the Government to perform mandatory vehicle inspection for public, commercial and private vehicles, receive many customers daily. Often complaints of problems received from the customers are associated with waiting time that leads to lost of business and dissatisfied customers. To address this issue, we propose a framework for modelling a vehicle inspection system using an integration of simulation and optimization approaches. The strengths of simulation and optimization are reviewed briefly that is hoped to reveal the synergy between the established methods in determining an appropriate customer's waiting time for inspection at a vehicle inspection centre. Relevant concepts and preliminary results are also presented and discussed in this paper.

Optimal plane search method in blood flow measurements by magnetic resonance imaging

NASA Astrophysics Data System (ADS)

Bargiel, Pawel; Orkisz, Maciej; Przelaskowski, Artur; Piatkowska-Janko, Ewa; Bogorodzki, Piotr; Wolak, Tomasz

2004-07-01

This paper offers an algorithm for determining the blood flow parameters in the neck vessel segments using a single (optimal) measurement plane instead of the usual approach involving four planes orthogonal to the artery axis. This new approach aims at significantly shortening the time required to complete measurements using Nuclear Magnetic Resonance techniques. Based on a defined error function, the algorithm scans the solution space to find the minimum of the error function, and thus to determine a single plane characterized by a minimum measurement error, which allows for an accurate measurement of blood flow in the four carotid arteries. The paper also comprises a practical implementation of this method (as a module of a larger imaging-measuring system), including preliminary research results.

Utilization of an agility assessment module in analysis and optimization of preliminary fighter configuration

NASA Technical Reports Server (NTRS)

Ngan, Angelen; Biezad, Daniel

1996-01-01

A study has been conducted to develop and to analyze a FORTRAN computer code for performing agility analysis on fighter aircraft configurations. This program is one of the modules of the NASA Ames ACSYNT (AirCraft SYNThesis) design code. The background of the agility research in the aircraft industry and a survey of a few agility metrics are discussed. The methodology, techniques, and models developed for the code are presented. The validity of the existing code was evaluated by comparing with existing flight test data. A FORTRAN program was developed for a specific metric, PM (Pointing Margin), as part of the agility module. Example trade studies using the agility module along with ACSYNT were conducted using a McDonnell Douglas F/A-18 Hornet aircraft model. Tile sensitivity of thrust loading, wing loading, and thrust vectoring on agility criteria were investigated. The module can compare the agility potential between different configurations and has capability to optimize agility performance in the preliminary design process. This research provides a new and useful design tool for analyzing fighter performance during air combat engagements in the preliminary design.

Magnetohydrodynamic Augmented Propulsion Experiment

NASA Technical Reports Server (NTRS)

Litchford, Ron J.

2008-01-01

Over the past several years, efforts have been under way to design and develop an operationally flexible research facility for investigating the use of cross-field MHD accelerators as a potential thrust augmentation device for thermal propulsion systems. The baseline configuration for this high-power experimental facility utilizes a 1.5-MWe multi-gas arc-heater as a thermal driver for a 2-MWe MHD accelerator, which resides in a large-bore 2-tesla electromagnet. A preliminary design study using NaK seeded nitrogen as the working fluid led to an externally diagonalized segmented MHD channel configuration based on an expendable heat-sink design concept. The current status report includes a review of engineering/design work and performance optimization analyses and summarizes component hardware fabrication and development efforts, preliminary testing results, and recent progress toward full-up assembly and testing

Status of Magnetohydrodynamic Augmented Propulsion Experiment

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Lineberry, John T.

2007-01-01

Over the past several years, efforts have been under way to design and develop an operationally flexible research facility for investigating the use of cross-field MHD accelerators as a potential thrust augmentation device for thermal propulsion systems, The baseline configuration for this high-power experimental facility utilizes a 1,5-MW, multi-gas arc-heater as a thermal driver for a 2-MW, MHD accelerator, which resides in a large-bore 2-tesla electromagnet. A preliminary design study using NaK seeded nitrogen as the working fluid led to an externally diagonalized segmented MHD channel configuration based on an expendable beat-sink design concept. The current status report includes a review of engineering/design work and performance optimization analyses and summarizes component hardware fabrication and development efforts, preliminary testing results, and recent progress toward full-up assembly and testing

Time optimal control of a jet engine using a quasi-Hermite interpolation model. M.S. Thesis

NASA Technical Reports Server (NTRS)

Comiskey, J. G.

1979-01-01

This work made preliminary efforts to generate nonlinear numerical models of a two-spooled turbofan jet engine, and subject these models to a known method of generating global, nonlinear, time optimal control laws. The models were derived numerically, directly from empirical data, as a first step in developing an automatic modelling procedure.

Investigating the optimality of proactive management of an invasive forest pest

Treesearch

Craig A. Bond; Patricia Champ; James Meldrum; Anna Schoettle

2011-01-01

This paper offers a preliminary investigation into the conditions under which it might be optimal to engage in proactive management of a non-timber forest resource in the presence of an invasive species whose spread is unaffected by management action. Proactive management is defined as treating an uninfected area to encourage healthy ecosystem function, given that the...

Proactive or reactive? Optimal management of an invasive forest pest in a spatial framework

Treesearch

Craig A. Bond; Patricia Champ; James Meldrum; Anna Schoettle

2010-01-01

This paper offers a preliminary investigation into the conditions under which it might be optimal to engage in proactive management of a non-timber forest resource in the presence of an invasive species whose spread is unaffected by management action. Proactive management is defined as treating an uninfected area in order to encourage healthy ecosystem...

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors.

PubMed

Vontzalidou, Argyro; Zoidis, Grigoris; Chaita, Eliza; Makropoulou, Maria; Aligiannis, Nektarios; Lambrinidis, George; Mikros, Emmanuel; Skaltsounis, Alexios-Leandros

2012-09-01

The synthesis, molecular modeling and biological evaluation of substituted deoxybenzoins and optimized dihydrostilbenes are reported. Preliminary structure-activity relationship data were elucidated and lead compounds suitable for further optimization were discovered. Dihydrostilbene 7 is a particularly potent inhibitor (IC(50)=8.44 μM, more potent than kojic acid). Copyright © 2012 Elsevier Ltd. All rights reserved.

Expert System Approach For Generating And Evaluating Engine Design Alternatives

NASA Astrophysics Data System (ADS)

Shen, Stewart N. T.; Chew, Meng-Sang; Issa, Ghassan F.

1989-03-01

Artificial intelligence is becoming an increasingly important subject of study for computer scientists, engineering designers, as well as professionals in other fields. Even though AI technology is a relatively new discipline, many of its concepts have already found practical applications. Expert systems, in particular, have made significant contributions to technologies in such fields as business, medicine, engineering design, chemistry, and particle physics. This paper describes an expert system developed to aid the mechanical designer with the preliminary design of variable-stroke internal-combustion engines. The expert system accomplished its task by generating and evaluating a large number of design alternatives represented in the form of graphs. Through the application of structural and design rules directly to the graphs, optimal and near optimal preliminary design configurations of engines are deduced.

What is unrealistic optimism?

PubMed

Jefferson, Anneli; Bortolotti, Lisa; Kuzmanovic, Bojana

2017-04-01

Here we consider the nature of unrealistic optimism and other related positive illusions. We are interested in whether cognitive states that are unrealistically optimistic are belief states, whether they are false, and whether they are epistemically irrational. We also ask to what extent unrealistically optimistic cognitive states are fixed. Based on the classic and recent empirical literature on unrealistic optimism, we offer some preliminary answers to these questions, thereby laying the foundations for answering further questions about unrealistic optimism, such as whether it has biological, psychological, or epistemic benefits. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Performance Gains of Propellant Management Devices for Liquid Hydrogen Depots

NASA Technical Reports Server (NTRS)

Hartwig, Jason W.; McQuillen, John B.; Chato, David J.

2013-01-01

This paper presents background, experimental design, and preliminary experimental results for the liquid hydrogen bubble point tests conducted at the Cryogenic Components Cell 7 facility at the NASA Glenn Research Center in Cleveland, Ohio. The purpose of the test series was to investigate the parameters that affect liquid acquisition device (LAD) performance in a liquid hydrogen (LH2) propellant tank, to mitigate risk in the final design of the LAD for the Cryogenic Propellant Storage and Transfer Technology Demonstration Mission, and to provide insight into optimal LAD operation for future LH2 depots. Preliminary test results show an increase in performance and screen retention over the low reference LH2 bubble point value for a 325 2300 screen in three separate ways, thus improving fundamental LH2 LAD performance. By using a finer mesh screen, operating at a colder liquid temperature, and pressurizing with a noncondensible pressurant gas, a significant increase in margin is achieved in bubble point pressure for LH2 screen channel LADs.

Prospects for reduced energy transports: A preliminary analysis

NASA Technical Reports Server (NTRS)

Ardema, M. D.; Harper, M.; Smith, C. L.; Waters, M. H.; Williams, L. J.

1974-01-01

The recent energy crisis and subsequent substantial increase in fuel prices have provided increased incentive to reduce the fuel consumption of civil transport aircraft. At the present time many changes in operational procedures have been introduced to decrease fuel consumption of the existing fleet. In the future, however, it may become desirable or even necessary to introduce new fuel-conservative aircraft designs. This paper reports the results of a preliminary study of new near-term fuel conservative aircraft. A parametric study was made to determine the effects of cruise Mach number and fuel cost on the optimum configuration characteristics and on economic performance. For each design, the wing geometry was optimized to give maximum return on investment at a particular fuel cost. Based on the results of the parametric study, a nominal reduced energy configuration was selected. Compared with existing transport designs, the reduced energy design has a higher aspect ratio wing with lower sweep, and cruises at a lower Mach number. It has about 30% less fuel consumption on a seat-mile basis.

Preliminary results from the High Speed Airframe Integration Research project

NASA Technical Reports Server (NTRS)

Coen, Peter G.; Sobieszczanski-Sobieski, Jaroslaw; Dollyhigh, Samuel M.

1992-01-01

A review is presented of the accomplishment of the near term objectives of developing an analysis system and optimization methods during the first year of the NASA Langley High Speed Airframe Integration Research (HiSAIR) project. The characteristics of a Mach 3 HSCT transport have been analyzed utilizing the newly developed process. In addition to showing more detailed information about the aerodynamic and structural coupling for this type of vehicle, this exercise aided in further refining the data requirements for the analysis process.

AIC Computations Using Navier-Stokes Equations on Single Image Supercomputers For Design Optimization

NASA Technical Reports Server (NTRS)

Guruswamy, Guru

2004-01-01

A procedure to accurately generate AIC using the Navier-Stokes solver including grid deformation is presented. Preliminary results show good comparisons between experiment and computed flutter boundaries for a rectangular wing. A full wing body configuration of an orbital space plane is selected for demonstration on a large number of processors. In the final paper the AIC of full wing body configuration will be computed. The scalability of the procedure on supercomputer will be demonstrated.

Hybrid supply chain model for material requirement planning under financial constraints: A case study

NASA Astrophysics Data System (ADS)

Curci, Vita; Dassisti, Michele; Josefa, Mula Bru; Manuel, Díaz Madroñero

2014-10-01

Supply chain model (SCM) are potentially capable to integrate different aspects in supporting decision making for enterprise management tasks. The aim of the paper is to propose an hybrid mathematical programming model for optimization of production requirements resources planning. The preliminary model was conceived bottom-up from a real industrial case analysed oriented to maximize cash flow. Despite the intense computational effort required to converge to a solution, optimisation done brought good result in solving the objective function.

Response of nickel to zinc cells to electric vehicle chopper discharge waveforms

NASA Technical Reports Server (NTRS)

Cataldo, R. L.

1981-01-01

The preliminary results of simulated electric vehicle chopper controlled discharge of a Nickel/Zinc battery shows delivered energy increases of 5 to 25 percent compared to constant current discharges of the same average current. The percentage increase was a function of chopper frequency, the ratio of peak to average current, and the magnitude of the discharge current. Because the chopper effects are of a complex nature, electric vehicle battery/speed controller interaction must be carefully considered in vehicle design to optimize battery performance.

Genetic Algorithm Tuned Fuzzy Logic for Gliding Return Trajectories

NASA Technical Reports Server (NTRS)

Burchett, Bradley T.

2003-01-01

The problem of designing and flying a trajectory for successful recovery of a reusable launch vehicle is tackled using fuzzy logic control with genetic algorithm optimization. The plant is approximated by a simplified three degree of freedom non-linear model. A baseline trajectory design and guidance algorithm consisting of several Mamdani type fuzzy controllers is tuned using a simple genetic algorithm. Preliminary results show that the performance of the overall system is shown to improve with genetic algorithm tuning.

Three-Dimensional Implant Positioning with a Piezosurgery Implant Site Preparation Technique and an Intraoral Surgical Navigation System: Case Report.

PubMed

Pellegrino, Gerardo; Taraschi, Valerio; Vercellotti, Tomaso; Ben-Nissan, Besim; Marchetti, Claudio

This case report describes new implant site preparation techniques joining the benefits of using an intraoral navigation system to optimize three-dimensional implant site positioning in combination with an ultrasonic osteotomy. A report of five patients is presented, and the implant positions as planned in the navigation software with the postoperative scan image were compared. The preliminary results are useful, although further clinical studies with larger populations are needed to confirm these findings.

Development of a Pneumatic Robot for MRI-guided Transperineal Prostate Biopsy and Brachytherapy: New Approaches

PubMed Central

Song, Sang-Eun; Cho, Nathan B.; Fischer, Gregory; Hata, Nobuhito; Tempany, Clare; Fichtinger, Gabor; Iordachita, Iulian

2011-01-01

Magnetic Resonance Imaging (MRI) guided prostate biopsy and brachytherapy has been introduced in order to enhance the cancer detection and treatment. For the accurate needle positioning, a number of robotic assistants have been developed. However, problems exist due to the strong magnetic field and limited workspace. Pneumatically actuated robots have shown the minimum distraction in the environment but the confined workspace limits optimal robot design and thus controllability is often poor. To overcome the problem, a simple external damping mechanism using timing belts was sought and a 1-DOF mechanism test result indicated sufficient positioning accuracy. Based on the damping mechanism and modular system design approach, a new workspace-optimized 4-DOF parallel robot was developed for the MRI-guided prostate biopsy and brachytherapy. A preliminary evaluation of the robot was conducted using previously developed pneumatic controller and satisfying results were obtained. PMID:21399734

OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma.

PubMed

Kaufman, Howard L; Bines, Steven D

2010-06-01

There are few effective treatment options available for patients with advanced melanoma. An oncolytic herpes simplex virus type 1 encoding granulocyte macrophage colony-stimulating factor (GM-CSF; Oncovex(GM-CSF)) for direct injection into accessible melanoma lesions resulted in a 28% objective response rate in a Phase II clinical trial. Responding patients demonstrated regression of both injected and noninjected lesions highlighting the dual mechanism of action of Oncovex(GM-CSF) that includes both a direct oncolytic effect in injected tumors and a secondary immune-mediated anti-tumor effect on noninjected tumors. Based on these preliminary results a prospective, randomized Phase III clinical trial in patients with unresectable Stage IIIb or c and Stage IV melanoma has been initiated. The rationale, study design, end points and future development of the Oncovex(GM-CSF) Pivotal Trial in Melanoma (OPTIM) trial are discussed in this article.

Introduction of the ASGARD code (Automated Selection and Grouping of events in AIA Regional Data)

NASA Astrophysics Data System (ADS)

Bethge, Christian; Winebarger, Amy; Tiwari, Sanjiv K.; Fayock, Brian

2017-08-01

We have developed the ASGARD code to automatically detect and group brightenings ("events") in AIA data. The event selection and grouping can be optimized to the respective dataset with a multitude of control parameters. The code was initially written for IRIS data, but has since been optimized for AIA. However, the underlying algorithm is not limited to either and could be used for other data as well.Results from datasets in various AIA channels show that brightenings are reliably detected and that coherent coronal structures can be isolated by using the obtained information about the start, peak, and end times of events. We are presently working on a follow-up algorithm to automatically determine the heating and cooling timescales of coronal structures. This will be done by correlating the information from different AIA channels with different temperature responses. We will present the code and preliminary results.

Cirrus Heterogeneity Effects on Cloud Optical Properties Retrieved with an Optimal Estimation Method from MODIS VIS to TIR Channels.

NASA Technical Reports Server (NTRS)

Fauchez, T.; Platnick, S.; Meyer, K.; Sourdeval, O.; Cornet, C.; Zhang, Z.; Szczap, F.

2016-01-01

This study presents preliminary results on the effect of cirrus heterogeneities on top-of-atmosphere (TOA) simulated radiances or reflectances for MODIS channels centered at 0.86, 2.21, 8.56, 11.01 and 12.03 micrometers , and on cloud optical properties retrieved with a research-level optimal estimation method (OEM). Synthetic cirrus cloud fields are generated using a 3D cloud generator (3DCLOUD) and radiances/reflectances are simulated using a 3D radiative transfer code (3DMCPOL). We find significant differences between the heterogeneity effects on either visible and near-infrared (VNIR) or thermal infrared (TIR) radiances. However, when both wavelength ranges are combined, heterogeneity effects are dominated by the VNIR horizontal radiative transport effect. As a result, small optical thicknesses are overestimated and large ones are underestimated. Retrieved effective diameter are found to be slightly affected, contrarily to retrievals using TIR channels only.

Polynomial elimination theory and non-linear stability analysis for the Euler equations

NASA Technical Reports Server (NTRS)

Kennon, S. R.; Dulikravich, G. S.; Jespersen, D. C.

1986-01-01

Numerical methods are presented that exploit the polynomial properties of discretizations of the Euler equations. It is noted that most finite difference or finite volume discretizations of the steady-state Euler equations produce a polynomial system of equations to be solved. These equations are solved using classical polynomial elimination theory, with some innovative modifications. This paper also presents some preliminary results of a new non-linear stability analysis technique. This technique is applicable to determining the stability of polynomial iterative schemes. Results are presented for applying the elimination technique to a one-dimensional test case. For this test case, the exact solution is computed in three iterations. The non-linear stability analysis is applied to determine the optimal time step for solving Burgers' equation using the MacCormack scheme. The estimated optimal time step is very close to the time step that arises from a linear stability analysis.

[Thoughts on optimizing the breast cancer screening strategies and implementation effects].

PubMed

Wu, K J

2018-02-01

Reasonable and effective breast cancer screening can make early diagnosis of breast cancer, improve the cure rate, prolong survival and improve the patients' quality of life. China has made preliminary exploration and attempt in breast cancer screening, however, there are still some problems that have not been solved in terms of the proportion of opportunistic screening, the selection of screening targets, methods and frequency, and the judgment of screening results. Therefore, this article analyzes the above problems in details, and presents some thoughts and recommendations on how to optimize the breast cancer screening strategies and implementation effects in China, from the experience of clinical practice, under the background of constantly emerging new research results and techniques and the rapid development of artificial intelligence, that is, to adjust measures to local conditions, provide personalized strategies, achieve precise screening, preach and educate, ensure health insurance coverage, improve quality control, offer technical support and employ artificial intelligence.

Optimization of Porous Pellets for Phosphate Recovery

EPA Science Inventory

The poster presents the preliminary adsorption experiment showing that phosphate concentration is decreasing over time as well as presenting the kinetics models that best fit the data collected over 25 days.

The role of oxidized regenerate cellulose to prevent cosmetic defects in oncoplastic breast surgery.

PubMed

Franceschini, G; Visconti, G; Terribile, D; Fabbri, C; Magno, S; Di Leone, A; Salgarello, M; Masetti, R

2012-07-01

Breast conserving surgery (BCS) combined with postoperative radiotherapy has become the gold standard of locoregional treatment for the majority of patients with early-stage breast cancer, offering equivalent survival and improved body image and lifestyle scores as compared to mastectomy. In an attempt to optimize the oncologic safety and cosmetic results of BCS, oncoplastic procedures (OPP) have been introduced in recent years combining the best principles of surgical oncology with those of plastic surgery. However, even with the use of OPP, cosmetic outcomes may result unsatisfying when a large volume of parenchyma has to be removed, particularly in small-medium size breasts. The aim of this article is to report our preliminary results with the use of oxidized regenerate cellulose (ORC) (Tabotamp fibrillar, Johnson & Johnson; Ethicon, USA) as an agent to prevent cosmetic defects in patients undergoing OPP for breast cancer and to analyze the technical refinements that can enhance its efficacy in optimizing cosmetic defects. Different OPP are selected based on the location and size of the tumor as well as volume and shape of the breast. After excision of the tumor, glandular flaps are created by dissection of the residual parenchyma from the pectoralis and serratus muscles and from the skin. After careful haemostasis, five layers of ORC are positioned on the pectoralis major in the residual cavity and covered by advancement of the glandular flaps. Two additional layers of ORC are positioned above the flaps and covered by cutaneous-subcutaenous flaps. The use of ORC after OPP has shown promising preliminary results, indicating a good tolerability and positive effects on cosmesis. This simple and reliable surgical technique may allow not only to reduce the rate of post-operative bleeding and infection at the surgical site but also to improve cosmetic results.

FOREX Trades: Can the Takens Algorithm Help to Obtain Steady Profit at Investment Reallocations?

NASA Astrophysics Data System (ADS)

Petrov, V. Yu.; Tribelsky, M. I.

2015-12-01

We report our preliminary results of application of the Takens algorithm to build a FOREX trade strategy, resulting in a steady long-time gain for a trader. The actual historical rates for pair EUR vs. USD are used. The values of various parameters of the problem including the "stop loss" and "take profit" thresholds are optimized to provide the maximal gain during the training period. Then, these values are employed for trades. We have succeeded to get the steady gain, if the spread is neglected. It proves that the FOREX market is predictable.

[Conservative anal fistula treatment with collagenic plug and human fibrin sealant. Preliminary results].

PubMed

Gubitosi, A; Moccia, G; Malinconico, F A; Docimo, G; Ruggiero, R; Iside, G; Avenia, N; Docimo, L; Foroni, F; Gilio, F; Sparavigna, L; Agresti, M

2009-01-01

The authors, on the basis of a long clinical experience with human fibrin glue in general surgery, compared two different extracellular matrix (collagen), Surgisis and TissueDura, with human fibrin glue, applied during the operation, and sometimes in postoperative, to obtain the healing of perianal fistulas. The collagenic extracellular matrix provides, according to the rationale suggested, an optimal three-dimensional structure for the fibroblastic implant and neoangiogenesis, hence for the fistula "fibrotizzation" and closure. The encouraging results for transphincteric fistulas and a simple and easy technique push to researchers on samples statistically significant.

Use of High Fidelity Methods in Multidisciplinary Optimization-A Preliminary Survey

NASA Technical Reports Server (NTRS)

Guruswamy, Guru P.; Kwak, Dochan (Technical Monitor)

2002-01-01

Multidisciplinary optimization is a key element of design process. To date multidiscipline optimization methods that use low fidelity methods are well advanced. Optimization methods based on simple linear aerodynamic equations and plate structural equations have been applied to complex aerospace configurations. However, use of high fidelity methods such as the Euler/ Navier-Stokes for fluids and 3-D (three dimensional) finite elements for structures has begun recently. As an activity of Multidiscipline Design Optimization Technical Committee (MDO TC) of AIAA (American Institute of Aeronautics and Astronautics), an effort was initiated to assess the status of the use of high fidelity methods in multidisciplinary optimization. Contributions were solicited through the members MDO TC committee. This paper provides a summary of that survey.

Multidisciplinary Optimization Methods for Aircraft Preliminary Design

NASA Technical Reports Server (NTRS)

Kroo, Ilan; Altus, Steve; Braun, Robert; Gage, Peter; Sobieski, Ian

1994-01-01

This paper describes a research program aimed at improved methods for multidisciplinary design and optimization of large-scale aeronautical systems. The research involves new approaches to system decomposition, interdisciplinary communication, and methods of exploiting coarse-grained parallelism for analysis and optimization. A new architecture, that involves a tight coupling between optimization and analysis, is intended to improve efficiency while simplifying the structure of multidisciplinary, computation-intensive design problems involving many analysis disciplines and perhaps hundreds of design variables. Work in two areas is described here: system decomposition using compatibility constraints to simplify the analysis structure and take advantage of coarse-grained parallelism; and collaborative optimization, a decomposition of the optimization process to permit parallel design and to simplify interdisciplinary communication requirements.

Development of a 10 MHz oscillator working with an LGT crystal resonator: preliminary results.

PubMed

Imbaud, Joël; Galliou, Serge; Romand, Jean Pierre; Abbe, Philippe; Bourquin, Roger

2008-09-01

Presently, to our knowledge, measurement of the noise of langatate (LGT) crystal oscillators has not previously been reported. First results of such a measurement are given in this paper. They have been obtained from 10 MHz resonator prototypes tested with a dedicated electronics. The main steps of the resonator manufacturing are described in this paper. Good quality factors, close to 1.4 10(6), have already been achieved on the 5th overtone of the thickness shear mode of LGT Y cuts, even if the energy trapping should still be optimized. The motional parameters of these resonator prototypes are quite different from those of usual quartz crystal resonators. As a consequence, dedicated sustaining electronics have been designed. The explored options are reported to justify the implemented one. Moreover, the high thermal sensitivity of LGT crystal resonators (parabolic f-T curve) requires that particular attention be paid to the oven thermal stability. This important feature is also pointed out in the paper. The preliminary version of the resulting system exhibits a relative frequency stability of 6 10(-12).

Global Cost and Weight Evaluation of Fuselage Side Panel Design Concepts

NASA Technical Reports Server (NTRS)

Polland, D. R.; Finn, S. R.; Griess, K. H.; Hafenrichter, J. L.; Hanson, C. T.; Ilcewicz, L. B.; Metschan, S. L.; Scholz, D. B.; Smith, P. J.

1997-01-01

This report documents preliminary design trades conducted under NASA contracts NAS1 18889 (Advanced Technology Composite Aircraft Structures, ATCAS) and NAS1-19349 (Task 3, Pathfinder Shell Design) for a subsonic wide body commercial aircraft fuselage side panel section utilizing composite materials. Included in this effort were (1) development of two complete design concepts, (2) generation of cost and weight estimates, (3) identification of technical issues and potential design enhancements, and (4) selection of a single design to be further developed. The first design concept featured an open-section stringer stiffened skin configuration while the second was based on honeycomb core sandwich construction. The trade study cost and weight results were generated from comprehensive assessment of each structural component comprising the fuselage side panel section from detail fabrication through airplane final assembly. Results were obtained in three phases: (1) for the baseline designs, (2) after global optimization of the designs, and (3) the results anticipated after detailed design optimization. A critical assessment of both designs was performed to determine the risk associated with each concept, that is the relative probability of achieving the cost and weight projections. Seven critical technical issues were identified as the first step towards side panel detailed design optimization.

Optimizing parameters of GTU cycle and design values of air-gas channel in a gas turbine with cooled nozzle and rotor blades

NASA Astrophysics Data System (ADS)

Kler, A. M.; Zakharov, Yu. B.

2012-09-01

The authors have formulated the problem of joint optimization of pressure and temperature of combustion products before gas turbine, profiles of nozzle and rotor blades of gas turbine, and cooling air flow rates through nozzle and rotor blades. The article offers an original approach to optimization of profiles of gas turbine blades where the optimized profiles are presented as linear combinations of preliminarily formed basic profiles. The given examples relate to optimization of the gas turbine unit on the criterion of power efficiency at preliminary heat removal from air flows supplied for the air-gas channel cooling and without such removal.

Preliminary Analysis of Optimal Round Trip Lunar Missions

NASA Astrophysics Data System (ADS)

Gagg Filho, L. A.; da Silva Fernandes, S.

2015-10-01

A study of optimal bi-impulsive trajectories of round trip lunar missions is presented in this paper. The optimization criterion is the total velocity increment. The dynamical model utilized to describe the motion of the space vehicle is a full lunar patched-conic approximation, which embraces the lunar patched-conic of the outgoing trip and the lunar patched-conic of the return mission. Each one of these parts is considered separately to solve an optimization problem of two degrees of freedom. The Sequential Gradient Restoration Algorithm (SGRA) is employed to achieve the optimal solutions, which show a good agreement with the ones provided by literature, and, proved to be consistent with the image trajectories theorem.

Optimized treatment conditions for textile wastewater reuse using photocatalytic processes under UV and visible light sources.

PubMed

Starling, Maria Clara V M; Castro, Luiz Augusto S; Marcelino, Rafaela B P; Leão, Mônica M D; Amorim, Camila C

2017-03-01

In this study, photo-Fenton systems using visible light sources with iron and ferrioxalate were tested for the DOC degradation and decolorization of textile wastewater. Textile wastewaters originated after the dyeing stage of dark-colored tissue in the textile industry, and the optimization of treatment processes was studied to produce water suitable for reuse. Dissolved organic carbon, absorbance, turbidity, anionic concentrations, carboxylic acids, and preliminary cost analysis were performed for the proposed treatments. Conventional photo-Fenton process achieved near 99 % DOC degradation rates and complete absorbance removal, and no carboxylic acids were found as products of degradation. Ferrioxalate photo-Fenton system achieved 82 % of DOC degradation and showed complete absorbance removal, and oxalic acid has been detected through HPLC analysis in the treated sample. In contrast, photo-peroxidation with UV light was proved effective only for absorbance removal, with DOC degradation efficiency near 50 %. Treated wastewater was compared with reclaimed water and had a similar quality, indicating that these processes can be effectively applied for textile wastewater reuse. The results of the preliminary cost analysis indicated costs of 0.91 to 1.07 US$ m -3 for the conventional and ferrioxalate photo-Fenton systems, respectively. Graphical Abstract ᅟ.

Martian resource locations: Identification and optimization

NASA Astrophysics Data System (ADS)

Chamitoff, Gregory; James, George; Barker, Donald; Dershowitz, Adam

2005-04-01

The identification and utilization of in situ Martian natural resources is the key to enable cost-effective long-duration missions and permanent human settlements on Mars. This paper presents a powerful software tool for analyzing Martian data from all sources, and for optimizing mission site selection based on resource collocation. This program, called Planetary Resource Optimization and Mapping Tool (PROMT), provides a wide range of analysis and display functions that can be applied to raw data or imagery. Thresholds, contours, custom algorithms, and graphical editing are some of the various methods that can be used to process data. Output maps can be created to identify surface regions on Mars that meet any specific criteria. The use of this tool for analyzing data, generating maps, and collocating features is demonstrated using data from the Mars Global Surveyor and the Odyssey spacecraft. The overall mission design objective is to maximize a combination of scientific return and self-sufficiency based on utilization of local materials. Landing site optimization involves maximizing accessibility to collocated science and resource features within a given mission radius. Mission types are categorized according to duration, energy resources, and in situ resource utilization. Preliminary optimization results are shown for a number of mission scenarios.

Simulation-based planning for theater air warfare

NASA Astrophysics Data System (ADS)

Popken, Douglas A.; Cox, Louis A., Jr.

2004-08-01

Planning for Theatre Air Warfare can be represented as a hierarchy of decisions. At the top level, surviving airframes must be assigned to roles (e.g., Air Defense, Counter Air, Close Air Support, and AAF Suppression) in each time period in response to changing enemy air defense capabilities, remaining targets, and roles of opposing aircraft. At the middle level, aircraft are allocated to specific targets to support their assigned roles. At the lowest level, routing and engagement decisions are made for individual missions. The decisions at each level form a set of time-sequenced Courses of Action taken by opposing forces. This paper introduces a set of simulation-based optimization heuristics operating within this planning hierarchy to optimize allocations of aircraft. The algorithms estimate distributions for stochastic outcomes of the pairs of Red/Blue decisions. Rather than using traditional stochastic dynamic programming to determine optimal strategies, we use an innovative combination of heuristics, simulation-optimization, and mathematical programming. Blue decisions are guided by a stochastic hill-climbing search algorithm while Red decisions are found by optimizing over a continuous representation of the decision space. Stochastic outcomes are then provided by fast, Lanchester-type attrition simulations. This paper summarizes preliminary results from top and middle level models.

An equivalent method for optimization of particle tuned mass damper based on experimental parametric study

NASA Astrophysics Data System (ADS)

Lu, Zheng; Chen, Xiaoyi; Zhou, Ying

2018-04-01

A particle tuned mass damper (PTMD) is a creative combination of a widely used tuned mass damper (TMD) and an efficient particle damper (PD) in the vibration control area. The performance of a one-storey steel frame attached with a PTMD is investigated through free vibration and shaking table tests. The influence of some key parameters (filling ratio of particles, auxiliary mass ratio, and particle density) on the vibration control effects is investigated, and it is shown that the attenuation level significantly depends on the filling ratio of particles. According to the experimental parametric study, some guidelines for optimization of the PTMD that mainly consider the filling ratio are proposed. Furthermore, an approximate analytical solution based on the concept of an equivalent single-particle damper is proposed, and it shows satisfied agreement between the simulation and experimental results. This simplified method is then used for the preliminary optimal design of a PTMD system, and a case study of a PTMD system attached to a five-storey steel structure following this optimization process is presented.

Multi-criteria multi-stakeholder decision analysis using a fuzzy-stochastic approach for hydrosystem management

NASA Astrophysics Data System (ADS)

Subagadis, Y. H.; Schütze, N.; Grundmann, J.

2014-09-01

The conventional methods used to solve multi-criteria multi-stakeholder problems are less strongly formulated, as they normally incorporate only homogeneous information at a time and suggest aggregating objectives of different decision-makers avoiding water-society interactions. In this contribution, Multi-Criteria Group Decision Analysis (MCGDA) using a fuzzy-stochastic approach has been proposed to rank a set of alternatives in water management decisions incorporating heterogeneous information under uncertainty. The decision making framework takes hydrologically, environmentally, and socio-economically motivated conflicting objectives into consideration. The criteria related to the performance of the physical system are optimized using multi-criteria simulation-based optimization, and fuzzy linguistic quantifiers have been used to evaluate subjective criteria and to assess stakeholders' degree of optimism. The proposed methodology is applied to find effective and robust intervention strategies for the management of a coastal hydrosystem affected by saltwater intrusion due to excessive groundwater extraction for irrigated agriculture and municipal use. Preliminary results show that the MCGDA based on a fuzzy-stochastic approach gives useful support for robust decision-making and is sensitive to the decision makers' degree of optimism.

Screening and optimization of pectin lyase and polygalacturonase activity from ginseng pathogen Cylindrocarpon Destructans

PubMed Central

Sathiyaraj, Gayathri; Srinivasan, Sathiyaraj; Kim, Ho-Bin; Subramaniyam, Sathiyamoorthy; Lee, Ok Ran; Kim, Yeon-Ju; Yang, Deok Chun

2011-01-01

Cylindrocarpon destructans isolated from ginseng field was found to produce pectinolytic enzymes. A Taguchi’s orthogonal array experimental design was applied to optimize the preliminary production of polygalacturonase (PG) and pectin lyase (PL) using submerged culture condition. This method was applied to evaluate the significant parameters for the production of enzymes. The process variables were pH, pectin concentration, incubation time and temperature. Optimization of process parameters resulted in high levels of enzyme (PG and PL) production after ten days of incubation at a pH of 5.0 at 25°C in the presence of 1.5% pectin. Among different nitrogen sources, urea and peptone showed high production of PG and PL, respectively. The enzyme production and mycelial growth seems to have direct influence on the culture conditions; therefore, at stationary state high enzyme production and mycelial growth were obtained than agitation state. Along with this, optimization of enzyme activity was also determined using various physiological parameters like, temperature, incubation time and pH. Taguchi’s data was also analyzed using one step ANOVA statistical method. PMID:24031695

Direct stenting with a combined intravascular ultrasound-coronary stent delivery platform: a feasibility trial.

PubMed

Eeckhout, Eric; Berger, Alexandre; Roguelov, Christan; Lyon, Xavier; Imsand, Christophe; Fivaz-Arbane, Malika; Girod, Grégoire; De Benedetti, Edoardo

2003-08-01

IVUS is considered as the most accurate tool for the assessment of optimal stent deployment. Direct stenting has shown to be a safe, efficient, and resource-saving procedure in selected patients. In a prospective 1-month feasibility trial, a new combined IVUS-coronary stent delivery platform (Josonics Flex, Jomed, Helsingborn, Sweden) was evaluated during direct stenting in consecutive patients considered eligible for direct stenting. The feasibility endpoint was successful stent deployment without any clinical adverse event, while the efficacy endpoint was strategic adaptation according to standard IVUS criteria for optimal stent deployment at the intermediate phase (after a result considered angiographically optimal) and at the end of the intervention (after optimization according to IVUS standards). A total of 16 patients were successfully treated with this device without any major clinical complication. At the intermediate phase, optimal stent deployment was achieved in four patients only, while at the end only one patient had nonoptimal IVUS stent deployment. In particular, the minimal in-stent cross-section area increased from 6.3 +/- 1.2 to 8.3 +/- 2.5 mm(2). These preliminary data demonstrate the feasibility of direct stenting with a combined IVUS-stent catheter in selected patients and confirm the results from larger randomized trials on the impact of IVUS on strategic adaptations during coronary stent placement. Copyright 2003 Wiley-Liss, Inc.

Preliminary design study of an alternate heat source assembly for a Brayton isotope power system

NASA Technical Reports Server (NTRS)

Strumpf, H. J.

1978-01-01

Results are presented for a study of the preliminary design of an alternate heat source assembly (HSA) intended for use in the Brayton isotope power system (BIPS). The BIPS converts thermal energy emitted by a radioactive heat source into electrical energy by means of a closed Brayton cycle. A heat source heat exchanger configuration was selected and optimized. The design consists of a 10 turn helically wound Hastelloy X tube. Thermal analyses were performed for various operating conditions to ensure that post impact containment shell (PICS) temperatures remain within specified limits. These limits are essentially satisfied for all modes of operation except for the emergency cooling system for which the PICS temperatures are too high. Neon was found to be the best choice for a fill gas for auxiliary cooling system operation. Low cycle fatigue life, natural frequency, and dynamic loading requirements can be met with minor modifications to the existing HSA.

Design study of wind turbines, 50 kW to 3000 kW for electric utility applications: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

Preliminary designs of low power (50 to 500 kW) and high power (500 to 3000 kW) wind generator systems (WGS) for electric utility applications were developed. These designs provide the bases for detail design, fabrication, and experimental demonstration testing of these units at selected utility sites. Several feasible WGS configurations were evaluated, and the concept offering the lowest energy cost potential and minimum technical risk for utility applications was selected. The selected concept was optimized utilizing a parametric computer program prepared for this purpose. The utility requirements evaluation task examined the economic, operational and institutional factors affecting the WGS in a utility environment, and provided additional guidance for the preliminary design effort. Results of the conceptual design task indicated that a rotor operating at constant speed, driving an AC generator through a gear transmission is the most cost effective WGS configuration.

Broadband spectrally dynamic solid state illumination source

NASA Astrophysics Data System (ADS)

Nicol, David B.; Asghar, Ali; Gupta, Shalini; Kang, Hun; Pan, Ming; Strassburg, Martin; Summers, Chris; Ferguson, Ian T.

2006-06-01

Solid state lighting has done well recently in niche markets such as signage and displays, however, no available SSL technologies incorporate all the necessary attributes for general illumination. Development of a novel solid state general illumination source is discussed here. Two LEDs emitting at two distinct wavelengths can be monolithically grown and used to excite two or more phosphors with varied excitation spectra. The combined phosphorescence spectrum can then be controlled by adjusting the relative intensities of the two LED emissions. Preliminary phosphor analysis shows such a scheme to be viable for use in a spectrally dynamic broadband general illumination source. A tunnel junction is envisioned as a means of current spreading in a buried layer for three terminal operation. However, tunnel junction properties in GaN based materials are not well understood, and require further optimization to be practical devices. Preliminary results on GaN tunnel junctions are presented here as well.

Preliminary study of rib articulated model based on dynamic fluoroscopy images

NASA Astrophysics Data System (ADS)

Villard, Pierre-Frederic; Escamilla, Pierre; Kerrien, Erwan; Gorges, Sebastien; Trousset, Yves; Berger, Marie-Odile

2014-03-01

We present in this paper a preliminary study of rib motion tracking during Interventional Radiology (IR) fluoroscopy guided procedures. It consists in providing a physician with moving rib three-dimensional (3D) models projected in the fluoroscopy plane during a treatment. The strategy is to help to quickly recognize the target and the no-go areas i.e. the tumor and the organs to avoid. The method consists in i) elaborating a kinematic model of each rib from a preoperative computerized tomography (CT) scan, ii) processing the on-line fluoroscopy image and iii) optimizing the parameters of the kinematic law such as the transformed 3D rib projected on the medical image plane fit well with the previously processed image. The results show a visually good rib tracking that has been quantitatively validated by showing a periodic motion as well as a good synchronism between ribs.

Self-organization in neural networks - Applications in structural optimization

NASA Technical Reports Server (NTRS)

Hajela, Prabhat; Fu, B.; Berke, Laszlo

1993-01-01

The present paper discusses the applicability of ART (Adaptive Resonance Theory) networks, and the Hopfield and Elastic networks, in problems of structural analysis and design. A characteristic of these network architectures is the ability to classify patterns presented as inputs into specific categories. The categories may themselves represent distinct procedural solution strategies. The paper shows how this property can be adapted in the structural analysis and design problem. A second application is the use of Hopfield and Elastic networks in optimization problems. Of particular interest are problems characterized by the presence of discrete and integer design variables. The parallel computing architecture that is typical of neural networks is shown to be effective in such problems. Results of preliminary implementations in structural design problems are also included in the paper.

PV integration into a CSP plant

NASA Astrophysics Data System (ADS)

Carvajal, Javier López; Barea, Jose M.; Barragan, Jose; Ortega, Carlos

2017-06-01

This paper describes a preliminary techno-economic analysis of the integration of a PV plant into an optimized Parabolic Trough Plant in order to reduce the online consumptions and thus, increase the net electricity injected into the grid. The idea is to assess the feasibility of such project and see what configuration would be the optimal. An extra effort has been made in terms of modelling as the analysis has to be done to the integrated CSP + PV plant instead of analyzing them independently. Two different technologies have been considered for the PV plant, fix and one-axis tracking. Additionally three different scenarios have been considered for the CSP plant auxiliary consumptions as they are essential for determining the optimal PV plant (the higher the auxiliary consumption the higher the optimal PV plant). As could be expected, the results for all cases with PV show an improvement in terms of electricity generation and also in terms of LCOE with respect to the CSP plant. Such improvement is slightly higher with tracking technology for this specific study. Although this exercise has been done to an already designed CSP plant (so only the PV plant had to be optimized), the methodology could be applied for the optimization of an integrated CSP + PV plant during the design phase.

Optimizing the Entrainment Geometry of a Dry Powder Inhaler: Methodology and Preliminary Results.

PubMed

Kopsch, Thomas; Murnane, Darragh; Symons, Digby

2016-11-01

For passive dry powder inhalers (DPIs) entrainment and emission of the aerosolized drug dose depends strongly on device geometry and the patient's inhalation manoeuvre. We propose a computational method for optimizing the entrainment part of a DPI. The approach assumes that the pulmonary delivery location of aerosol can be determined by the timing of dose emission into the tidal airstream. An optimization algorithm was used to iteratively perform computational fluid dynamic (CFD) simulations of the drug emission of a DPI. The algorithm seeks to improve performance by changing the device geometry. Objectives were to achieve drug emission that was: A) independent of inhalation manoeuvre; B) similar to a target profile. The simulations used complete inhalation flow-rate profiles generated dependent on the device resistance. The CFD solver was OpenFOAM with drug/air flow simulated by the Eulerian-Eulerian method. To demonstrate the method, a 2D geometry was optimized for inhalation independence (comparing two breath profiles) and an early-bolus delivery. Entrainment was both shear-driven and gas-assisted. Optimization for a delay in the bolus delivery was not possible with the chosen geometry. Computational optimization of a DPI geometry for most similar drug delivery has been accomplished for an example entrainment geometry.

Evaluation of orbits with incomplete knowledge of the mathematical expectancy and the matrix of covariation of errors

NASA Technical Reports Server (NTRS)

Bakhshiyan, B. T.; Nazirov, R. R.; Elyasberg, P. E.

1980-01-01

The problem of selecting the optimal algorithm of filtration and the optimal composition of the measurements is examined assuming that the precise values of the mathematical expectancy and the matrix of covariation of errors are unknown. It is demonstrated that the optimal algorithm of filtration may be utilized for making some parameters more precise (for example, the parameters of the gravitational fields) after preliminary determination of the elements of the orbit by a simpler method of processing (for example, the method of least squares).

Extraction optimization, preliminary characterization and antioxidant activities of polysaccharides from Glycine soja.

PubMed

Jing, Changliang; Yuan, Yuan; Tang, Qi; Zou, Ping; Li, Yiqiang; Zhang, Chengsheng

2017-10-01

Single-factor experiment and Central Composite Design (CCD) was applied to optimize the ultrasound-assisted extraction (UAE) conditions of polysaccharides from Glycine soja (CGPS), and a preliminary characterization of three polysaccharide fractions (CGPS, GPS-1, and GPS-2) and their antioxidant activities were investigated. Under the optimal conditions: ratio of liquid to solid 42.7mL/g, extraction power 293.7W, extraction temperature 68.9°C, and extraction time 34.7min, the experimental CGPS yield was 6.04mg/g. CGPS was further purified by DEAE-cellulose and Sephadex-100 chromatography to obtain two fractions (GPS-1 and GPS-2), and their monosaccharides compositions were characterized by HPLC. Fourier-transform infrared spectra (FT-IR) indicated the chemical structures of them. Moreover, they exhibited high antioxidant activities in a concentration-dependent manner in vitro. In summary, the present study suggested that UAE was a very effective method to extract polysaccharides from Glycine soja and the polysaccharides could be explored as potential antioxidant agents for medicine and function food. Copyright © 2017 Elsevier B.V. All rights reserved.

A preliminary look at an optimal multivariable design for propulsion-only flight control of jet-transport aircraft

NASA Technical Reports Server (NTRS)

Azzano, Christopher P.

1992-01-01

Control of a large jet transport aircraft without the use of conventional control surfaces was studied. Engine commands were used to attempt to recreate the forces and moments typically provided by the elevator, ailerons, and rudder. Necessary conditions for aircraft controllability were developed pertaining to aircraft configuration such as the number of engines and engine placement. An optimal linear quadratic regulator controller was developed for the Boeing 707-720, in particular, for regulation of its natural dynamic modes. The design used a method of assigning relative weights to the natural modes, i.e., phugoid and dutch roll, for a more intuitive selection of the cost function. A prototype pilot command interface was then integrated into the loop based on pseudorate command of both pitch and roll. Closed loop dynamics were evaluated first with a batch linear simulation and then with a real time high fidelity piloted simulation. The NASA research pilots assisted in evaluation of closed loop handling qualities for typical cruise and landing tasks. Recommendations for improvement on this preliminary study of optimal propulsion only flight control are provided.

Micro Asteroid Prospector Powered by Energetic Radioisotopes: MAPPER

NASA Astrophysics Data System (ADS)

Howe, Steven D.; Jackson, Gerald P.

2005-02-01

The solar system is an almost limitless store-house of resources. As humanity begins to expand into space, we can greatly reduce the cost and effort of exploration by using the resources from other orbiting bodies. The ability to extract volatile gases or structural materials from moons and other planetesimals will allow smaller ships, faster missions, and lower costs. Part of the problem, however, will be to locate the desired deposits from the billions of square miles of surface area present in the solar system. The asteroid belt between Mars and Jupiter is perhaps the most valuable and most overlooked of resource deposits in the solar system. The total mass of the Belt is estimated to be 1/1000 the mass of the Earth. The ultimate goal of this project is to identify and investigate an exploration architecture that would allow a hundreds of ultra-light-weight instrument packages to be sent to the Asteroid Belt. We have performed a preliminary analysis that has characterized the bodies in the Asteroid Belt, identified subsystems needed on the platform, and completed a preliminary optimization of the flight profile and propulsion characteristics to maximize the number of bodies that could be catalogued. The results showed that the mass and power of the platform is strongly dependent upon the average cruise velocity, the specific impulse of the thruster, and the time to accelerate up to speed. The preliminary optimization indicates that the best cruise velocity is around 0.5 km/s and the best Isp is 1500 s. Our conclusion is that platforms with near 100 kg total mass could be built relatively inexpensively. This many spacecraft would catalogue an area equivalent to 20% the area of the Earth's surface in a 20 year period.

Modeling human decision making behavior in supervisory control

NASA Technical Reports Server (NTRS)

Tulga, M. K.; Sheridan, T. B.

1977-01-01

An optimal decision control model was developed, which is based primarily on a dynamic programming algorithm which looks at all the available task possibilities, charts an optimal trajectory, and commits itself to do the first step (i.e., follow the optimal trajectory during the next time period), and then iterates the calculation. A Bayesian estimator was included which estimates the tasks which might occur in the immediate future and provides this information to the dynamic programming routine. Preliminary trials comparing the human subject's performance to that of the optimal model show a great similarity, but indicate that the human skips certain movements which require quick change in strategy.

Combined structures-controls optimization of lattice trusses

NASA Technical Reports Server (NTRS)

Balakrishnan, A. V.

1991-01-01

The role that distributed parameter model can play in CSI is demonstrated, in particular in combined structures controls optimization problems of importance in preliminary design. Closed form solutions can be obtained for performance criteria such as rms attitude error, making possible analytical solutions of the optimization problem. This is in contrast to the need for numerical computer solution involving the inversion of large matrices in traditional finite element model (FEM) use. Another advantage of the analytic solution is that it can provide much needed insight into phenomena that can otherwise be obscured or difficult to discern from numerical computer results. As a compromise in level of complexity between a toy lab model and a real space structure, the lattice truss used in the EPS (Earth Pointing Satellite) was chosen. The optimization problem chosen is a generic one: of minimizing the structure mass subject to a specified stability margin and to a specified upper bond on the rms attitude error, using a co-located controller and sensors. Standard FEM treating each bar as a truss element is used, while the continuum model is anisotropic Timoshenko beam model. Performance criteria are derived for each model, except that for the distributed parameter model, explicit closed form solutions was obtained. Numerical results obtained by the two model show complete agreement.

Illumination system development using design and analysis of computer experiments

NASA Astrophysics Data System (ADS)

Keresztes, Janos C.; De Ketelaere, Bart; Audenaert, Jan; Koshel, R. J.; Saeys, Wouter

2015-09-01

Computer assisted optimal illumination design is crucial when developing cost-effective machine vision systems. Standard local optimization methods, such as downhill simplex optimization (DHSO), often result in an optimal solution that is influenced by the starting point by converging to a local minimum, especially when dealing with high dimensional illumination designs or nonlinear merit spaces. This work presents a novel nonlinear optimization approach, based on design and analysis of computer experiments (DACE). The methodology is first illustrated with a 2D case study of four light sources symmetrically positioned along a fixed arc in order to obtain optimal irradiance uniformity on a flat Lambertian reflecting target at the arc center. The first step consists of choosing angular positions with no overlap between sources using a fast, flexible space filling design. Ray-tracing simulations are then performed at the design points and a merit function is used for each configuration to quantify the homogeneity of the irradiance at the target. The obtained homogeneities at the design points are further used as input to a Gaussian Process (GP), which develops a preliminary distribution for the expected merit space. Global optimization is then performed on the GP more likely providing optimal parameters. Next, the light positioning case study is further investigated by varying the radius of the arc, and by adding two spots symmetrically positioned along an arc diametrically opposed to the first one. The added value of using DACE with regard to the performance in convergence is 6 times faster than the standard simplex method for equal uniformity of 97%. The obtained results were successfully validated experimentally using a short-wavelength infrared (SWIR) hyperspectral imager monitoring a Spectralon panel illuminated by tungsten halogen sources with 10% of relative error.

Optimization of Selective Laser Melting by Evaluation Method of Multiple Quality Characteristics

NASA Astrophysics Data System (ADS)

Khaimovich, A. I.; Stepanenko, I. S.; Smelov, V. G.

2018-01-01

Article describes the adoption of the Taguchi method in selective laser melting process of sector of combustion chamber by numerical and natural experiments for achieving minimum temperature deformation. The aim was to produce a quality part with minimum amount of numeric experiments. For the study, the following optimization parameters (independent factors) were chosen: the laser beam power and velocity; two factors for compensating the effect of the residual thermal stresses: the scale factor of the preliminary correction of the part geometry and the number of additional reinforcing elements. We used an orthogonal plan of 9 experiments with a factor variation at three levels (L9). As quality criterias, the values of distortions for 9 zones of the combustion chamber and the maximum strength of the material of the chamber were chosen. Since the quality parameters are multidirectional, a grey relational analysis was used to solve the optimization problem for multiple quality parameters. As a result, according to the parameters obtained, the combustion chamber segments of the gas turbine engine were manufactured.

PREPARATION AND PROPERTIES OF COMPOUND ARNEBIAE RADIX MICROEMULSION GEL.

PubMed

Chen, Jing; He, Yanping; Gao, Ting; Zhang, Licheng; Zhao, Yuna

2017-01-01

Compound Arnebiae radix oil has been clinically applied to treat burns and scalds for a long time. However, it is unstable and inconvenient to use. The aim of this study was to prepare a compound Arnebiae radix microemulsion gel for transdermal delivery system and evaluate its characteristics. Based on the solubility of Shikonin, the active component of Arnebiae radix and the results of phase studies, adequate ratio of each component in microemulsion was determined. The optimized microemulsion gel was prepared using Carbomer 940. The gels were characterized in terms of appearance, preliminary stability test and the content of Shikonin in the compound Arnebiae radix microemulsion gel with HPLC analysis. The optimized conditions for preparing microemulsion were Tween-80, glycerin, isopropyl myristate (IPM) with the ratio of 6:3:2. The optimal microemulsion gel was obtained with Carbomer 940 (1.0%). The prepared compound Arnebiae radix microemulsion gel showed good stability over time. It is more convenience in application than the previous used formulations.

Spectrally optimal illuminations for diabetic retinopathy detection in retinal imaging

NASA Astrophysics Data System (ADS)

Bartczak, Piotr; Fält, Pauli; Penttinen, Niko; Ylitepsa, Pasi; Laaksonen, Lauri; Lensu, Lasse; Hauta-Kasari, Markku; Uusitalo, Hannu

2017-04-01

Retinal photography is a standard method for recording retinal diseases for subsequent analysis and diagnosis. However, the currently used white light or red-free retinal imaging does not necessarily provide the best possible visibility of different types of retinal lesions, important when developing diagnostic tools for handheld devices, such as smartphones. Using specifically designed illumination, the visibility and contrast of retinal lesions could be improved. In this study, spectrally optimal illuminations for diabetic retinopathy lesion visualization are implemented using a spectrally tunable light source based on digital micromirror device. The applicability of this method was tested in vivo by taking retinal monochrome images from the eyes of five diabetic volunteers and two non-diabetic control subjects. For comparison to existing methods, we evaluated the contrast of retinal images taken with our method and red-free illumination. The preliminary results show that the use of optimal illuminations improved the contrast of diabetic lesions in retinal images by 30-70%, compared to the traditional red-free illumination imaging.

On Revenue-Optimal Dynamic Auctions for Bidders with Interdependent Values

NASA Astrophysics Data System (ADS)

Constantin, Florin; Parkes, David C.

In a dynamic market, being able to update one's value based on information available to other bidders currently in the market can be critical to having profitable transactions. This is nicely captured by the model of interdependent values (IDV): a bidder's value can explicitly depend on the private information of other bidders. In this paper we present preliminary results about the revenue properties of dynamic auctions for IDV bidders. We adopt a computational approach to design single-item revenue-optimal dynamic auctions with known arrivals and departures but (private) signals that arrive online. In leveraging a characterization of truthful auctions, we present a mixed-integer programming formulation of the design problem. Although a discretization is imposed on bidder signals the solution is a mechanism applicable to continuous signals. The formulation size grows exponentially in the dependence of bidders' values on other bidders' signals. We highlight general properties of revenue-optimal dynamic auctions in a simple parametrized example and study the sensitivity of prices and revenue to model parameters.

An Innovative Design of a Clay-Zeolite Medium for the Adsorption of Total Phosphorus from Wastewater.

PubMed

Ciosek, Amanda Lidia; Luk, Grace K; Warner, Michèle; Warner, R Anthony

2016-02-01

Phosphorus significantly influences the eutrophication process, modifying the quality of waterways and habitat, especially in stagnant waterbodies exposed to septic tank effluent at high nutrient levels. This research explores the development of a cost-effective, efficient, and affordable on-site wastewater treatment system targeted as total phosphorus (TP) removal technology. The research objective is to demonstrate the TP removal efficiency of an optimized clay-zeolite medium by chemical adsorption. The study observes the effects of pellet medium design and modifications, influent concentrations, and contact time. Following various stages of optimization, the preliminary testing achieves a 45 ± 1.8% removal after 45 minutes of contact time. The optimized pellets are contained within a five-layer bench-scale model, achieving equilibrium TP removal of 72 ± 2.9% after 3 hours. Theoretical extrapolation to 12 contact hours indicates an achievement of 88% removal is possible. The results show a positive correlation with the linearized Langmuir and Freundlich adsorption isotherms.

Preliminary design study of a lateral-directional control system using thrust vectoring

NASA Technical Reports Server (NTRS)

Lallman, F. J.

1985-01-01

A preliminary design of a lateral-directional control system for a fighter airplane capable of controlled operation at extreme angles of attack is developed. The subject airplane is representative of a modern twin-engine high-performance jet fighter, is equipped with ailerons, rudder, and independent horizontal-tail surfaces. Idealized bidirectional thrust-vectoring engine nozzles are appended to the mathematic model of the airplane to provide additional control moments. Optimal schedules for lateral and directional pseudo control variables are calculated. Use of pseudo controls results in coordinated operation of the aerodynamic and thrust-vectoring controls with minimum coupling between the lateral and directional airplane dynamics. Linear quadratic regulator designs are used to specify a preliminary flight control system to improve the stability and response characteristics of the airplane. Simulated responses to step pilot control inputs are stable and well behaved. For lateral stick deflections, peak stability axis roll rates are between 1.25 and 1.60 rad/sec over an angle-of-attack range of 10 deg to 70 deg. For rudder pedal deflections, the roll rates accompanying the sideslip responses can be arrested by small lateral stick motions.

Preliminary Process Design of ITER ELM Coil Bracket Brazing

NASA Astrophysics Data System (ADS)

LI, Xiangbin; SHI, Yi

2015-03-01

With the technical requirement of the International Thermonuclear Experimental Reactor (ITER) project, the manufacture and assembly technology of the mid Edge Localized Modes (ELM) coil was developed by the Institute of Plasma Physics, Chinese Academy of Science (ASIPP). As the gap between the bracket and the Stainless Steel jacketed and Mineral Insulated Conductor (SSMIC) can be larger than 0.5 mm instead of 0.01 mm to 0.1 mm as in normal industrial cases, the process of mid ELM coil bracket brazing to the SSMICT becomes quiet challenging, from a technical viewpoint. This paper described the preliminary design of ELM coil bracket brazing to the SSMIC process, the optimal bracket brazing curve and the thermal simulation of the bracket furnace brazing method developed by ANSYS. BAg-6 foil (Bag50Cu34Zn16) plus BAg-1a paste (Bag45CuZnCd) solders were chosen as the brazing filler. By testing an SSMICT prototype, it is shown that the average gap between the bracket and the SSMIC could be controlled to 0.2-0.3 mm, and that there were few voids in the brazing surface. The results also verified that the preliminary design had a favorable heat conducting performance in the bracket.

Effects of inclination and eccentricity on optimal trajectories between earth and Venus

NASA Technical Reports Server (NTRS)

Gravier, J.-P.; Marchal, C.; Culp, R. D.

1973-01-01

The true optimal transfers, including the effects of the inclination and eccentricity of the planets' orbits, between earth and Venus are presented as functions of the corresponding idealized Hohmann transfers. The method of determining the optimal transfers using the calculus of variations is presented. For every possible Hohmann window, specified as a continuous function of the longitude of perihelion of the Hohmann trajectory, the corresponding numerically exact optimal two-impulse transfers are given in graphical form. The cases for which the optimal two-impulse transfer is the absolute optimal, and those for which a three-impulse transfer provides the absolute optimal transfer are indicated. This information furnishes everything necessary for quick and accurate orbit calculations for preliminary Venus mission analysis. This makes it possible to use the actual optimal transfers for advanced planning in place of the standard Hohmann transfers.

Multi-Disciplinary Design Optimization Using WAVE

NASA Technical Reports Server (NTRS)

Irwin, Keith

2000-01-01

The current preliminary design tools lack the product performance, quality and cost prediction fidelity required to design Six Sigma products. They are also frequently incompatible with the tools used in detailed design, leading to a great deal of rework and lost or discarded data in the transition from preliminary to detailed design. Thus, enhanced preliminary design tools are needed in order to produce adequate financial returns to the business. To achieve this goal, GEAE has focused on building the preliminary design system around the same geometric 3D solid model that will be used in detailed design. With this approach, the preliminary designer will no longer convert a flowpath sketch into an engine cross section but rather, automatically create 3D solid geometry for structural integrity, life, weight, cost, complexity, producibility, and maintainability assessments. Likewise, both the preliminary design and the detailed design can benefit from the use of the same preliminary part sizing routines. The design analysis tools will also be integrated with the 3D solid model to eliminate manual transfer of data between programs. GEAE has aggressively pursued the computerized control of engineering knowledge for many years. Through its study and validation of 3D CAD programs and processes, GEAE concluded that total system control was not feasible at that time. Prior CAD tools focused exclusively on detail part geometry and Knowledge Based Engineering systems concentrated on rules input and data output. A system was needed to bridge the gap between the two to capture the total system. With the introduction of WAVE Engineering from UGS, the possibilities of an engineering system control device began to formulate. GEAE decided to investigate the new WAVE functionality to accomplish this task. NASA joined GEAE in funding this validation project through Task Order No. 1. With the validation project complete, the second phase under Task Order No. 2 was established to develop an associative control structure (framework) in the UG WAVE environment enabling multi-disciplinary design of turbine propulsion systems. The capabilities of WAVE were evaluated to assess its use as a rapid optimization and productivity tool. This project also identified future WAVE product enhancements that will make the tool still more beneficial for product development.

Optimizing a Sensor Network with Data from Hazard Mapping Demonstrated in a Heavy-Vehicle Manufacturing Facility.

PubMed

Berman, Jesse D; Peters, Thomas M; Koehler, Kirsten A

2018-05-28

To design a method that uses preliminary hazard mapping data to optimize the number and location of sensors within a network for a long-term assessment of occupational concentrations, while preserving temporal variability, accuracy, and precision of predicted hazards. Particle number concentrations (PNCs) and respirable mass concentrations (RMCs) were measured with direct-reading instruments in a large heavy-vehicle manufacturing facility at 80-82 locations during 7 mapping events, stratified by day and season. Using kriged hazard mapping, a statistical approach identified optimal orders for removing locations to capture temporal variability and high prediction precision of PNC and RMC concentrations. We compared optimal-removal, random-removal, and least-optimal-removal orders to bound prediction performance. The temporal variability of PNC was found to be higher than RMC with low correlation between the two particulate metrics (ρ = 0.30). Optimal-removal orders resulted in more accurate PNC kriged estimates (root mean square error [RMSE] = 49.2) at sample locations compared with random-removal order (RMSE = 55.7). For estimates at locations having concentrations in the upper 10th percentile, the optimal-removal order preserved average estimated concentrations better than random- or least-optimal-removal orders (P < 0.01). However, estimated average concentrations using an optimal-removal were not statistically different than random-removal when averaged over the entire facility. No statistical difference was observed for optimal- and random-removal methods for RMCs that were less variable in time and space than PNCs. Optimized removal performed better than random-removal in preserving high temporal variability and accuracy of hazard map for PNC, but not for the more spatially homogeneous RMC. These results can be used to reduce the number of locations used in a network of static sensors for long-term monitoring of hazards in the workplace, without sacrificing prediction performance.

Requirements analysis and preliminary design of a robotic assistant for reconstructive microsurgery.

PubMed

Vanthournhout, L; Herman, B; Duisit, J; Château, F; Szewczyk, J; Lengelé, B; Raucent, B

2015-08-01

Microanastomosis is a microsurgical gesture that involves suturing two very small blood vessels together. This gesture is used in many operations such as avulsed member auto-grafting, pediatric surgery, reconstructive surgery - including breast reconstruction by free flap. When vessels have diameters smaller than one millimeter, hand tremors make movements difficult to control. This paper introduces our preliminary steps towards robotic assistance for helping surgeons to perform microanastomosis in optimal conditions, in order to increase gesture quality and reliability even on smaller diameters. A general needs assessment and an experimental motion analysis were performed to define the requirements of the robot. Geometric parameters of the kinematic structure were then optimized to fulfill specific objectives. A prototype of the robot is currently being designed and built in order to providing a sufficient increase in accuracy without prolonging the duration of the procedure.

Mathematical modelling of risk reduction in reinsurance

NASA Astrophysics Data System (ADS)

Balashov, R. B.; Kryanev, A. V.; Sliva, D. E.

2017-01-01

The paper presents a mathematical model of efficient portfolio formation in the reinsurance markets. The presented approach provides the optimal ratio between the expected value of return and the risk of yield values below a certain level. The uncertainty in the return values is conditioned by use of expert evaluations and preliminary calculations, which result in expected return values and the corresponding risk levels. The proposed method allows for implementation of computationally simple schemes and algorithms for numerical calculation of the numerical structure of the efficient portfolios of reinsurance contracts of a given insurance company.

Microwave Measurement of Refractory Materials at High-Temperature

NASA Astrophysics Data System (ADS)

Kharkovsky, S.; Zoughi, R.; Smith, J.; Davis, B.; Limmer, R.

2009-03-01

Knowledge of the electrical behavior of refractory materials may enable the development and optimization of microwave nondestructive techniques to detect and evaluate changes in their physical properties while the materials are in service. This paper presents the results of a limited and preliminary investigation in which two refractory materials (dense chrome and dense zircon) were subjected to increasing temperature in a furnace and in which a frequency-modulated continuous-wave radar operating in the frequency range of 8-18 GHz radar was used to evaluate their attenuation properties.

Long-range, noncoherent laser Doppler velocimeter.

PubMed

Bloom, S H; Kremer, R; Searcy, P A; Rivers, M; Menders, J; Korevaar, E

1991-11-15

An experimental demonstration of a long-range, noncoherent laser Doppler velocimeter (LDV) is presented. The LDV detects incoming Doppler-shifted signal photons by using the sharp spectral absorption features in atomic or molecular vapors. The edge of the absorption feature is used to convert changes in frequency to large changes in transmission. Preliminary measurements of wind velocity using seeded aerosols showed that the LDV results agreed with mechanical anemometer measurements to within the accuracy of the LDV measurements. With optimization the LDV will provide accurate range-resolved and vibration-tolerant wind-speed measurements at large distances.

Initial Assessment of the Consolidation of Chalcogels into a Viable Waste Form

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riley, Brian J.; Lepry, William C.

2012-08-31

This report provides some preliminary data for the consolidation of chalcogen-based aerogels. The chalcogels tested to date at PNNL show great promise as iodine sorbents and preliminary consolidation research shows that they can be melted into a phase-pure glass at moderate temperatures. The preliminary consolidation experiments show that these materials might attack fused quartz so an alternative crucible material will likely need to be used to prevent this. The next steps will be to • Consider melting other chalcogel chemistries, e.g., Sn-Sb-S, Ge-Sn-S chalcogels • Consider melting chalcogels with adsorbed iodine to monitor iodine loss during melting • Optimize themore » consolidation temperatures to minimize the iodine loss and volatilization« less

Preliminary Design Optimization For A Supersonic Turbine For Rocket Propulsion

NASA Technical Reports Server (NTRS)

Papila, Nilay; Shyy, Wei; Griffin, Lisa; Huber, Frank; Tran, Ken; McConnaughey, Helen (Technical Monitor)

2000-01-01

In this study, we present a method for optimizing, at the preliminary design level, a supersonic turbine for rocket propulsion system application. Single-, two- and three-stage turbines are considered with the number of design variables increasing from 6 to 11 then to 15, in accordance with the number of stages. Due to its global nature and flexibility in handling different types of information, the response surface methodology (RSM) is applied in the present study. A major goal of the present Optimization effort is to balance the desire of maximizing aerodynamic performance and minimizing weight. To ascertain required predictive capability of the RSM, a two-level domain refinement approach has been adopted. The accuracy of the predicted optimal design points based on this strategy is shown to he satisfactory. Our investigation indicates that the efficiency rises quickly from single stage to 2 stages but that the increase is much less pronounced with 3 stages. A 1-stage turbine performs poorly under the engine balance boundary condition. A portion of fluid kinetic energy is lost at the turbine discharge of the 1-stage design due to high stage pressure ratio and high-energy content, mostly hydrogen, of the working fluid. Regarding the optimization technique, issues related to the design of experiments (DOE) has also been investigated. It is demonstrated that the criteria for selecting the data base exhibit significant impact on the efficiency and effectiveness of the construction of the response surface.

A preliminary study to metaheuristic approach in multilayer radiation shielding optimization

NASA Astrophysics Data System (ADS)

Arif Sazali, Muhammad; Rashid, Nahrul Khair Alang Md; Hamzah, Khaidzir

2018-01-01

Metaheuristics are high-level algorithmic concepts that can be used to develop heuristic optimization algorithms. One of their applications is to find optimal or near optimal solutions to combinatorial optimization problems (COPs) such as scheduling, vehicle routing, and timetabling. Combinatorial optimization deals with finding optimal combinations or permutations in a given set of problem components when exhaustive search is not feasible. A radiation shield made of several layers of different materials can be regarded as a COP. The time taken to optimize the shield may be too high when several parameters are involved such as the number of materials, the thickness of layers, and the arrangement of materials. Metaheuristics can be applied to reduce the optimization time, trading guaranteed optimal solutions for near-optimal solutions in comparably short amount of time. The application of metaheuristics for radiation shield optimization is lacking. In this paper, we present a review on the suitability of using metaheuristics in multilayer shielding design, specifically the genetic algorithm and ant colony optimization algorithm (ACO). We would also like to propose an optimization model based on the ACO method.

SU-E-T-488: An Iso-Dose Curve Based Interactive IMRT Optimization System for Physician-Driven Plan Tuning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shi, F; Tian, Z; Jia, X

Purpose: In treatment plan optimization for Intensity Modulated Radiation Therapy (IMRT), after a plan is initially developed by a dosimetrist, the attending physician evaluates its quality and often would like to improve it. As opposed to having the dosimetrist implement the improvements, it is desirable to have the physician directly and efficiently modify the plan for a more streamlined and effective workflow. In this project, we developed an interactive optimization system for physicians to conveniently and efficiently fine-tune iso-dose curves. Methods: An interactive interface is developed under C++/Qt. The physician first examines iso-dose lines. S/he then picks an iso-dose curvemore » to be improved and drags it to a more desired configuration using a computer mouse or touchpad. Once the mouse is released, a voxel-based optimization engine is launched. The weighting factors corresponding to voxels between the iso-dose lines before and after the dragging are modified. The underlying algorithm then takes these factors as input to re-optimize the plan in near real-time on a GPU platform, yielding a new plan best matching the physician's desire. The re-optimized DVHs and iso-dose curves are then updated for the next iteration of modifications. This process is repeated until a physician satisfactory plan is achieved. Results: We have tested this system for a series of IMRT plans. Results indicate that our system provides the physicians an intuitive and efficient tool to edit the iso-dose curves according to their preference. The input information is used to guide plan re-optimization, which is achieved in near real-time using our GPU-based optimization engine. Typically, a satisfactory plan can be developed by a physician in a few minutes using this tool. Conclusion: With our system, physicians are able to manipulate iso-dose curves according to their preferences. Preliminary results demonstrate the feasibility and effectiveness of this tool.« less

Textile wastewater treatment and reuse by solar catalysis: results from a pilot plant in Tunisia.

PubMed

Bousselmi, L; Geissen, S U; Schroeder, H

2004-01-01

Based on results from bench-scale flow-film-reactors (FFR) and aerated cascade photoreactors, a solar catalytic pilot plant has been built at the site of a textile factory. This plant has an illuminated surface area of 50 m2 and is designed for the treatment of 1 m3 h(-1) of wastewater. The preliminary results are presented and compared with a bench-scale FFR using textile wastewater and dichloroacetic acid. Equivalent degradation kinetics were obtained and it was demonstrated that the solar catalytic technology is able to remove recalcitrant compounds and color. However, on-site optimization is still necessary for wastewater reuse and for an economic application.

Preliminary Design of an Autonomous Underwater Vehicle Using Multi-Objective Optimization

DTIC Science & Technology

2014-03-01

fuel cell PC propulsive coefficient PEMFC proton exchange membrane fuel cell PHP propulsive horsepower PO Pareto optimal PSO particle swarm...membrane fuel cell ( PEMFC ), molten carbonate fuel cell (MCFC), solid oxide fuel cell (SOFC) and direct and indirect methanol fuel cell (DMFC). Figure...of fuel cells in depth, I will note that PEMFCs are smaller and have a lower operating temperature compared to the other types. Those are the main

Preliminary test data using the MOS DRO with Si:In detector material

NASA Technical Reports Server (NTRS)

Fowler, A. M.; Britt, J. P.; Joyce, R. R.; Probst, R. G.; Gates, J. L.

1986-01-01

The initial testing performed on the Hughes Metal Oxide Semiconductor Direct Readout (MOS DRO) with a Si:In extrinsic infrared array is described. The testing to date was of a screening nature and the results are primarily qualitative rather than quantitative. At a later date the performance optimization phase will be initiated. An encouraging result is that this response is strongly dependent on the detector temperature, to the extent that thermal transients introduced during the chip readout will affect the performance. A responsivity of 1 A/W at 2.2 microns with a bias of 15 volts, which is well below what is optimum bias, was obtained.

Combined Numerical/Analytical Perturbation Solutions of the Navier-Stokes Equations for Aerodynamic (Ejector Nozzle) Flows

NASA Technical Reports Server (NTRS)

DeChant, Lawrence J.

1997-01-01

In spite of the rapid advances in both scalar and parallel computational tools, the large number and breadth of variables involved in aerodynamic systems make the use of parabolized or even boundary layer fluid flow models impractical for both preliminary design and inverse design problems. Given this restriction, we have concluded that reduced or approximate models are an important family of tools for design purposes. This study of a combined perturbation/numerical modeling methodology with an application to ejector-mixer nozzles (shown schematically in the following figure) is nearing completion. The work is being funded by a grant from the NASA Lewis Research Center to Texas A&M University. These ejector-mixer nozzle models are designed to be of use to the High Speed Civil Transport Program and may be adopted by both NASA and industry. A computer code incorporating the ejector-mixer models is under development. This code, the Differential Reduced Ejector/Mixer Analysis (DREA), can be run fast enough to be used as a subroutine or to be called by a design optimization routine. Simplified conservation equations--x-momentum, energy, and mass conservation--are used to define the model. Unlike other preliminary design models, DREA requires minimal empirical input and includes vortical mixing and a fully compressible formulation among other features. DREA is being validated by comparing it with results obtained from open literature and proprietary industry data. Preliminary results for a subsonic ejector and a supersonic ejector are shown. In addition, dedicated experiments have been performed at Texas A&M. These experiments use a hydraulic/gas flow analog to provide information about the inviscid mixing interface structure. Final validation and documentation of this work is expected by May of 1997. However, preliminary versions of DREA can be expected in early 1997. In summary, DREA provides a sufficiently detailed and realistic ejector-mixer nozzle model at a computational cost compatible with preliminary design applications.

Conception preliminaire de disques de turbine axiale pour moteurs d'aeronefs

NASA Astrophysics Data System (ADS)

Ouellet, Yannick

The preliminary design phase of a turbine rotor has an important impact on the architecture of a new engine definition, as it sets the technical orientation right from start and provides a good estimate of product performance, weight and cost. In addition, the execution speed at this preliminary phase has become critical into capturing business opportunities. Improving upfront accuracy also alleviates downstream detailed design work and therefore reduces overall product development cycle time. This preliminary phase contains elements slowing down its process, including low interoperability of currently used systems, incompatibility of software and ineffective management of data. In order to overcome these barriers, we have developed the first module of a new Design and Analysis (D&A) platform for the rotor disc. This complete platform ensures integration of different tools processing in batch mode, and is driven from a single graphical user interface. The platform developed has been linked with different optimization methods (algorithms, configuration) in order to automate the disc design and propose best practices for rotor structural optimization. This methodology allowed reduction in design cycle time and improvement of performance. It was applied on two reference P&WC axial discs. The platform's architecture was also used in the development of reference charts to better understand disc performance within given design space. Four high pressure rotor discs of P&WC turbofan and turboprop engines were used to generate the technical charts and understand the effect of various parameters. The new tools supporting disc D&A, combined with the optimization process and reference charts, has proven to be profitable in terms of component performance and engineering effort inputs.

Design Optimization of Gas Generator Hybrid Propulsion Boosters

NASA Technical Reports Server (NTRS)

Weldon, Vincent; Phillips, Dwight; Fink, Larry

1990-01-01

A methodology used in support of a study for NASA/MSFC to optimize the design of gas generator hybrid propulsion booster for uprating the National Space Transportation System (NSTS) is presented. The objective was to compare alternative configurations for this booster approach, optimizing each candidate concept on different bases, in order to develop data for a trade table on which a final decision was based. The methodology is capable of processing a large number of independent and dependent variables, adjusting the overall subsystems characteristics to arrive at a best compromise integrated design to meet various specific optimization criteria subject to selected constraints. For each system considered, a detailed weight statement was generated along with preliminary cost and reliability estimates.

Influence of Articulating Paper Thickness on Occlusal Contacts Registration: A Preliminary Report.

PubMed

Brizuela-Velasco, Aritza; Álvarez-Arenal, Ángel; Ellakuria-Echevarria, Joseba; del Río-Highsmith, Jaime; Santamaría-Arrieta, Gorka; Martín-Blanco, Nerea

2015-01-01

The objective of this preliminary study was to determine if the occlusal contact surface registered with an articulating paper during fixed prosthodontic treatment was contained within the area marked on a thicker articulating paper. This information would optimize any necessary occlusal adjustment of a prosthesis' veneering material. A convenience sample of 15 patients who were being treated with an implant-supported fixed singleunit dental prosthesis was selected. Occlusal registrations were obtained from each patient using 12-μm, 40-μm, 80-μm, and 200-μm articulating paper. Photographs of the occlusal registrations were obtained, and pixel measurements of the surfaces were taken and overlapped for comparison. The results showed that the thicker the articulating paper, the larger the occlusal contact area obtained. The differences were statistically significant. In all cases, the occlusal registrations obtained with the thinnest articulating paper were contained within the area marked on the thickest articulating paper. The results suggested that the use of thin articulating papers (12-μm or 40-μm) can avoid unnecessary grinding of veneering material or teeth during occlusal adjustment.

Technical Status Report: Preliminary Glass Formulation Report for INEEL HAW. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peeler, D.; Reamer, I.; Vienna, J.

1998-03-01

Preliminary glass formulation work has been initiated at Pacific Northwest National Laboratory (PNNL) and the Savannah River Technology Center (SRTC) to support immobilization efforts of Idaho National Engineering and Environmental Laboratory (INEEL) high activity waste (HAW). Based on current pretreatment flow sheet assumptions, several glasses were fabricated and tested using an average `All Blend` waste stream composition which is dominated by the presence of ZrO{sub 2} (i.e., approximately 80 wt percent). The results of this initial work show that immobilization via vitrification is a viable option for a specific INEEL HAW waste stream. Waste loadings of at least 19 wtmore » percent can be achieved for the `All Blend` stream while maintaining targeted processing and product performance criteria. This waste loading translates into a ZrO{sub 2} content in excess of 15 wt percent in the final glass waste form. Frits developed for this work are based in the alkali borosilicate system. Although the results indicate that vitrification can be used to immobilize the `All Blend` waste stream, the glass compositions are by no means optimized.« less

Radiation Mitigation and Power Optimization Design Tools for Reconfigurable Hardware in Orbit

NASA Technical Reports Server (NTRS)

French, Matthew; Graham, Paul; Wirthlin, Michael; Wang, Li; Larchev, Gregory

2005-01-01

The Reconfigurable Hardware in Orbit (RHinO)project is focused on creating a set of design tools that facilitate and automate design techniques for reconfigurable computing in space, using SRAM-based field-programmable-gate-array (FPGA) technology. In the second year of the project, design tools that leverage an established FPGA design environment have been created to visualize and analyze an FPGA circuit for radiation weaknesses and power inefficiencies. For radiation, a single event Upset (SEU) emulator, persistence analysis tool, and a half-latch removal tool for Xilinx/Virtex-II devices have been created. Research is underway on a persistence mitigation tool and multiple bit upsets (MBU) studies. For power, synthesis level dynamic power visualization and analysis tools have been completed. Power optimization tools are under development and preliminary test results are positive.

Design of a sensor network for structural health monitoring of a full-scale composite horizontal tail

NASA Astrophysics Data System (ADS)

Gao, Dongyue; Wang, Yishou; Wu, Zhanjun; Rahim, Gorgin; Bai, Shengbao

2014-05-01

The detection capability of a given structural health monitoring (SHM) system strongly depends on its sensor network placement. In order to minimize the number of sensors while maximizing the detection capability, optimal design of the PZT sensor network placement is necessary for structural health monitoring (SHM) of a full-scale composite horizontal tail. In this study, the sensor network optimization was simplified as a problem of determining the sensor array placement between stiffeners to achieve the desired the coverage rate. First, an analysis of the structural layout and load distribution of a composite horizontal tail was performed. The constraint conditions of the optimal design were presented. Then, the SHM algorithm of the composite horizontal tail under static load was proposed. Based on the given SHM algorithm, a sensor network was designed for the full-scale composite horizontal tail structure. Effective profiles of cross-stiffener paths (CRPs) and uncross-stiffener paths (URPs) were estimated by a Lamb wave propagation experiment in a multi-stiffener composite specimen. Based on the coverage rate and the redundancy requirements, a seven-sensor array-network was chosen as the optimal sensor network for each airfoil. Finally, a preliminary SHM experiment was performed on a typical composite aircraft structure component. The reliability of the SHM result for a composite horizontal tail structure under static load was validated. In the result, the red zone represented the delamination damage. The detection capability of the optimized sensor network was verified by SHM of a full-scale composite horizontal tail; all the diagnosis results were obtained in two minutes. The result showed that all the damage in the monitoring region was covered by the sensor network.

A new DWT/MC/DPCM video compression framework based on EBCOT

NASA Astrophysics Data System (ADS)

Mei, L. M.; Wu, H. R.; Tan, D. M.

2005-07-01

A novel Discrete Wavelet Transform (DWT)/Motion Compensation (MC)/Differential Pulse Code Modulation (DPCM) video compression framework is proposed in this paper. Although the Discrete Cosine Transform (DCT)/MC/DPCM is the mainstream framework for video coders in industry and international standards, the idea of DWT/MC/DPCM has existed for more than one decade in the literature and the investigation is still undergoing. The contribution of this work is twofold. Firstly, the Embedded Block Coding with Optimal Truncation (EBCOT) is used here as the compression engine for both intra- and inter-frame coding, which provides good compression ratio and embedded rate-distortion (R-D) optimization mechanism. This is an extension of the EBCOT application from still images to videos. Secondly, this framework offers a good interface for the Perceptual Distortion Measure (PDM) based on the Human Visual System (HVS) where the Mean Squared Error (MSE) can be easily replaced with the PDM in the R-D optimization. Some of the preliminary results are reported here. They are also compared with benchmarks such as MPEG-2 and MPEG-4 version 2. The results demonstrate that under specified condition the proposed coder outperforms the benchmarks in terms of rate vs. distortion.

Optimization of intra-voxel incoherent motion imaging at 3.0 Tesla for fast liver examination.

PubMed

Leporq, Benjamin; Saint-Jalmes, Hervé; Rabrait, Cecile; Pilleul, Frank; Guillaud, Olivier; Dumortier, Jérôme; Scoazec, Jean-Yves; Beuf, Olivier

2015-05-01

Optimization of multi b-values MR protocol for fast intra-voxel incoherent motion imaging of the liver at 3.0 Tesla. A comparison of four different acquisition protocols were carried out based on estimated IVIM (DSlow , DFast , and f) and ADC-parameters in 25 healthy volunteers. The effects of respiratory gating compared with free breathing acquisition then diffusion gradient scheme (simultaneous or sequential) and finally use of weighted averaging for different b-values were assessed. An optimization study based on Cramer-Rao lower bound theory was then performed to minimize the number of b-values required for a suitable quantification. The duration-optimized protocol was evaluated on 12 patients with chronic liver diseases No significant differences of IVIM parameters were observed between the assessed protocols. Only four b-values (0, 12, 82, and 1310 s.mm(-2) ) were found mandatory to perform a suitable quantification of IVIM parameters. DSlow and DFast significantly decreased between nonadvanced and advanced fibrosis (P < 0.05 and P < 0.01) whereas perfusion fraction and ADC variations were not found to be significant. Results showed that IVIM could be performed in free breathing, with a weighted-averaging procedure, a simultaneous diffusion gradient scheme and only four optimized b-values (0, 10, 80, and 800) reducing scan duration by a factor of nine compared with a nonoptimized protocol. Preliminary results have shown that parameters such as DSlow and DFast based on optimized IVIM protocol can be relevant biomarkers to distinguish between nonadvanced and advanced fibrosis. © 2014 Wiley Periodicals, Inc.

Response Surface Methodology Optimization of Ultrasonic-Assisted Extraction of Acer Truncatum Leaves for Maximal Phenolic Yield and Antioxidant Activity.

PubMed

Yang, Lingguang; Yin, Peipei; Fan, Hang; Xue, Qiang; Li, Ke; Li, Xiang; Sun, Liwei; Liu, Yujun

2017-02-04

This study is the first to report the use of response surface methodology to improve phenolic yield and antioxidant activity of Acer truncatum leaves extracts (ATLs) obtained by ultrasonic-assisted extraction. The phenolic composition in ATLs extracted under the optimized conditions were characterized by UPLC-QTOF-MS/MS. Solvent and extraction time were selected based on preliminary experiments, and a four-factors-three-levels central composite design was conducted to optimize solvent concentration ( X ₁), material-to-liquid ratio ( X ₂), ultrasonic temperature ( X ₃) and power ( X ₄) for an optimal total phenol yield ( Y ₁) and DPPH• antioxidant activity ( Y ₂). The results showed that the optimal combination was ethanol:water ( v : v ) 66.21%, material-to-liquid ratio 1:15.31 g/mL, ultrasonic bath temperature 60 °C, power 267.30 W, and time 30 min with three extractions, giving a maximal total phenol yield of 7593.62 mg gallic acid equivalent/100 g d.w. and a maximal DPPH• antioxidant activity of 74,241.61 μmol Trolox equivalent/100 g d.w. Furthermore, 22 phenolics were first identified in ATL extract obtained under the optimized conditions, indicating that gallates, gallotannins, quercetin, myricetin and chlorogenic acid derivatives were the main phenolic components in ATL. What's more, a gallotannins pathway existing in ATL from gallic acid to penta- O -galloylglucoside was proposed. All these results provide practical information aiming at full utilization of phenolics in ATL, together with fundamental knowledge for further research.

Preliminary field investigation of intelligent compaction of hot-mix asphalt.

DOT National Transportation Integrated Search

2007-01-01

Attention is being directed toward intelligent compaction (IC) of pavement layers, which uses rollers especially manufactured to determine the degree of compaction and regulate the compactive effort required to produce a pavement layer with the optim...

Structural analysis for preliminary design of High Speed Civil Transport (HSCT)

NASA Technical Reports Server (NTRS)

Bhatia, Kumar G.

1992-01-01

In the preliminary design environment, there is a need for quick evaluation of configuration and material concepts. The simplified beam representations used in the subsonic, high aspect ratio wing platform are not applicable for low aspect ratio configurations typical of supersonic transports. There is a requirement to develop methods for efficient generation of structural arrangement and finite element representation to support multidisciplinary analysis and optimization. In addition, empirical data bases required to validate prediction methods need to be improved for high speed civil transport (HSCT) type configurations.

Shape Optimization of the Assisted Bi-directional Glenn surgery for stage-1 single ventricle palliation

NASA Astrophysics Data System (ADS)

Verma, Aekaansh; Shang, Jessica; Esmaily-Moghadam, Mahdi; Wong, Kwai; Marsden, Alison

2016-11-01

Babies born with a single functional ventricle typically undergo three open-heart surgeries starting as neonates. The first of these stages (BT shunt or Norwood) has the highest mortality rates of the three, approaching 30%. Proceeding directly to a stage-2 Glenn surgery has historically demonstrated inadequate pulmonary flow (PF) & high mortality. Recently, the Assisted Bi-directional Glenn (ABG) was proposed as a promising means to achieve a stable physiology by assisting the PF via an 'ejector pump' from the systemic circulation. We present preliminary parametrization and optimization results for the ABG geometry, with the goal of increasing PF. To limit excessive pressure increases in the Superior Vena Cava (SVC), the SVC pressure is included as a constraint. We use 3-D finite element flow simulations coupled with a single ventricle lumped parameter network to evaluate PF & the pressure constraint. We employ a derivative free optimization method- the Surrogate Management Framework, in conjunction with the OpenDIEL framework to simulate multiple simultaneous evaluations. Results show that nozzle diameter is the most important design parameter affecting ABG performance. The application of these results to patient specific situations will be discussed. This work was supported by an NSF CAREER award (OCI1150184) and by the XSEDE National Computing Resource.

Minimizing Uncertainties Impact in Decision Making with an Applicability Study for Economic Power Dispatch

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Hong; Wang, Shaobu; Fan, Rui

This report summaries the work performed under the LDRD project on the preliminary study on knowledge automation, where specific focus has been made on the investigation of the impact of uncertainties of human decision making onto the optimization of the process operation. At first the statistics on signals from the Brain-Computing Interface (BCI) is analyzed so as to obtain the uncertainties characterization of human operators during the decision making phase using the electroencephalogram (EEG) signals. This is then followed by the discussions of an architecture that reveals the equivalence between optimization and closed loop feedback control design, where it hasmore » been shown that all the optimization problems can be transferred into the control design problem for closed loop systems. This has led to a “closed loop” framework, where the structure of the decision making is shown to be subjected to both process disturbances and controller’s uncertainties. The latter can well represent the uncertainties or randomness occurred during human decision making phase. As a result, a stochastic optimization problem has been formulated and a novel solution has been proposed using probability density function (PDF) shaping for both the cost function and the constraints using stochastic distribution control concept. A sufficient condition has been derived that guarantees the convergence of the optimal solution and discussions have been made for both the total probabilistic solution and chanced constrained optimization which have been well-studied in optimal power flows (OPF) area. A simple case study has been carried out for the economic dispatch of powers for a grid system when there are distributed energy resources (DERs) in the system, and encouraging results have been obtained showing that a significant savings on the generation cost can be expected.« less

Shape Optimization of Supersonic Turbines Using Response Surface and Neural Network Methods

NASA Technical Reports Server (NTRS)

Papila, Nilay; Shyy, Wei; Griffin, Lisa W.; Dorney, Daniel J.

2001-01-01

Turbine performance directly affects engine specific impulse, thrust-to-weight ratio, and cost in a rocket propulsion system. A global optimization framework combining the radial basis neural network (RBNN) and the polynomial-based response surface method (RSM) is constructed for shape optimization of a supersonic turbine. Based on the optimized preliminary design, shape optimization is performed for the first vane and blade of a 2-stage supersonic turbine, involving O(10) design variables. The design of experiment approach is adopted to reduce the data size needed by the optimization task. It is demonstrated that a major merit of the global optimization approach is that it enables one to adaptively revise the design space to perform multiple optimization cycles. This benefit is realized when an optimal design approaches the boundary of a pre-defined design space. Furthermore, by inspecting the influence of each design variable, one can also gain insight into the existence of multiple design choices and select the optimum design based on other factors such as stress and materials considerations.

A Preliminary Engineering Design of Intravascular Dual-Frequency Transducers for Contrast-Enhanced Acoustic Angiography and Molecular Imaging

PubMed Central

Ma, Jianguo; Martin, K. Heath; Dayton, Paul A.; Jiang, Xiaoning

2014-01-01

Current intravascular ultrasound (IVUS) probes are not optimized for contrast detection because of their design for high-frequency fundamental-mode imaging. However, data from transcutaneous contrast imaging suggests the possibility of utilizing contrast ultrasound for molecular imaging or vasa vasorum assessment to further elucidate atherosclerotic plaque deposition. This paper presents the design, fabrication, and characterization of a small-aperture (0.6 × 3 mm) IVUS probe optimized for high-frequency contrast imaging. The design utilizes a dual-frequency (6.5 MHz/30 MHz) transducer arrangement for exciting microbubbles at low frequencies (near their resonance) and detecting their broadband harmonics at high frequencies, minimizing detected tissue backscatter. The prototype probe is able to generate nonlinear microbubble response with more than 1.2 MPa of rarefractional pressure (mechanical index: 0.48) at 6.5 MHz, and is also able to detect microbubble response with a broadband receiving element (center frequency: 30 MHz, −6-dB fractional bandwidth: 58.6%). Nonlinear super-harmonics from microbubbles flowing through a 200-μm-diameter micro-tube were clearly detected with a signal-to-noise ratio higher than 12 dB. Preliminary phantom imaging at the fundamental frequency (30 MHz) and dual-frequency super-harmonic imaging results suggest the promise of small aperture, dual-frequency IVUS transducers for contrast-enhanced IVUS imaging. PMID:24801226

Multidisciplinary Design Optimization for Aeropropulsion Engines and Solid Modeling/Animation via the Integrated Forced Methods

NASA Technical Reports Server (NTRS)

2004-01-01

The grant closure report is organized in the following four chapters: Chapter describes the two research areas Design optimization and Solid mechanics. Ten journal publications are listed in the second chapter. Five highlights is the subject matter of chapter three. CHAPTER 1. The Design Optimization Test Bed CometBoards. CHAPTER 2. Solid Mechanics: Integrated Force Method of Analysis. CHAPTER 3. Five Highlights: Neural Network and Regression Methods Demonstrated in the Design Optimization of a Subsonic Aircraft. Neural Network and Regression Soft Model Extended for PX-300 Aircraft Engine. Engine with Regression and Neural Network Approximators Designed. Cascade Optimization Strategy with Neural network and Regression Approximations Demonstrated on a Preliminary Aircraft Engine Design. Neural Network and Regression Approximations Used in Aircraft Design.

Optimizing the implementation of the target motion sampling temperature treatment technique - How fast can it get?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuomas, V.; Jaakko, L.

This article discusses the optimization of the target motion sampling (TMS) temperature treatment method, previously implemented in the Monte Carlo reactor physics code Serpent 2. The TMS method was introduced in [1] and first practical results were presented at the PHYSOR 2012 conference [2]. The method is a stochastic method for taking the effect of thermal motion into account on-the-fly in a Monte Carlo neutron transport calculation. It is based on sampling the target velocities at collision sites and then utilizing the 0 K cross sections at target-at-rest frame for reaction sampling. The fact that the total cross section becomesmore » a distributed quantity is handled using rejection sampling techniques. The original implementation of the TMS requires 2.0 times more CPU time in a PWR pin-cell case than a conventional Monte Carlo calculation relying on pre-broadened effective cross sections. In a HTGR case examined in this paper the overhead factor is as high as 3.6. By first changing from a multi-group to a continuous-energy implementation and then fine-tuning a parameter affecting the conservativity of the majorant cross section, it is possible to decrease the overhead factors to 1.4 and 2.3, respectively. Preliminary calculations are also made using a new and yet incomplete optimization method in which the temperature of the basis cross section is increased above 0 K. It seems that with the new approach it may be possible to decrease the factors even as low as 1.06 and 1.33, respectively, but its functionality has not yet been proven. Therefore, these performance measures should be considered preliminary. (authors)« less

An Optimized Centrifugal Method for Separation of Semen from Superabsorbent Polymers for Forensic Analysis.

PubMed

Camarena, Lucy R; Glasscock, Bailey K; Daniels, Demi; Ackley, Nicolle; Sciarretta, Marybeth; Seashols-Williams, Sarah J

2017-03-01

Connection of a perpetrator to a sexual assault is best performed through the confirmed presence of semen, thereby proving sexual contact. Evidentiary items can include sanitary napkins or diapers containing superabsorbent polymers (SAPs), complicating spermatozoa visualization and DNA analysis. In this report, we evaluated the impact of SAPS on the current forensic DNA workflow, developing an efficient centrifugal protocol for separating spermatozoa from SAP material. The optimized filtration method was compared to common practices of excising the top layer only, resulting in significantly higher sperm yields when a core sample of the substrate was taken. Direct isolation of the SAP-containing materials without filtering resulted in 20% sample failure; additionally, SAP material was observed in the final eluted DNA samples, causing physical interference. Thus, use of the described centrifugal-filtering method is a simple preliminary step that improves spermatozoa visualization and enables more consistent DNA yields, while also avoiding SAP interference. © 2016 American Academy of Forensic Sciences.

Application-Oriented Chemical Optimization of a Metakaolin Based Geopolymer.

PubMed

Ferone, Claudio; Colangelo, Francesco; Roviello, Giuseppina; Asprone, Domenico; Menna, Costantino; Balsamo, Alberto; Prota, Andrea; Cioffi, Raffaele; Manfredi, Gaetano

2013-05-10

In this study the development of a metakaolin based geopolymeric mortar to be used as bonding matrix for external strengthening of reinforced concrete beams is reported. Four geopolymer formulations have been obtained by varying the composition of the activating solution in terms of SiO₂/Na₂O ratio. The obtained samples have been characterized from a structural, microstructural and mechanical point of view. The differences in structure and microstructure have been correlated to the mechanical properties. A major issue of drying shrinkage has been encountered in the high Si/Al ratio samples. In the light of the characterization results, the optimal geopolymer composition was then applied to fasten steel fibers to reinforced concrete beams. The mechanical behavior of the strengthened reinforced beams was evaluated by four-points bending tests, which were performed also on reinforced concrete beams as they are for comparison. The preliminary results of the bending tests point out an excellent behavior of the geopolymeric mixture tested, with the failure load of the reinforced beams roughly twice that of the control beam.

Plasma motor generator system

NASA Technical Reports Server (NTRS)

Hite, Gerald E.

1987-01-01

The significant potential advantages of a plasma motor generator system over conventional systems for the generation of electrical power and propulsion for spacecraft in low Earth orbits warrants its further investigation. The two main components of such a system are a long insulated wire and the plasma generating hollow cathodes needed to maintain electrical contact with the ionosphere. Results of preliminary theoretical and experimental investigations of this system are presented. The theoretical work involved the equilibrium configurations of the wire and the nature of small oscillation about these equilibrium positions. A particularly interesting result was that two different configurations are allowed when the current is above a critical value. Experimental investigations were made of the optimal starting and running conditions for the proposed, low current hollow cathodes. Although optimal ranges of temperature, argon pressure and discharge voltage were identified, start up became progressively more difficult. This supposed depletion or contamination of the emissive surface could be countered by the addition of new emissive material.

GTX Reference Vehicle Structural Verification Methods and Weight Summary

NASA Technical Reports Server (NTRS)

Hunter, J. E.; McCurdy, D. R.; Dunn, P. W.

2002-01-01

The design of a single-stage-to-orbit air breathing propulsion system requires the simultaneous development of a reference launch vehicle in order to achieve the optimal mission performance. Accordingly, for the GTX study a 300-lb payload reference vehicle was preliminary sized to a gross liftoff weight (GLOW) of 238,000 lb. A finite element model of the integrated vehicle/propulsion system was subjected to the trajectory environment and subsequently optimized for structural efficiency. This study involved the development of aerodynamic loads mapped to finite element models of the integrated system in order to assess vehicle margins of safety. Commercially available analysis codes were used in the process along with some internally developed spread-sheets and FORTRAN codes specific to the GTX geometry for mapping of thermal and pressure loads. A mass fraction of 0.20 for the integrated system dry weight has been the driver for a vehicle design consisting of state-of-the-art composite materials in order to meet the rigid weight requirements. This paper summarizes the methodology used for preliminary analyses and presents the current status of the weight optimization for the structural components of the integrated system.

Inverse problem and variation method to optimize cascade heat exchange network in central heating system

NASA Astrophysics Data System (ADS)

Zhang, Yin; Wei, Zhiyuan; Zhang, Yinping; Wang, Xin

2017-12-01

Urban heating in northern China accounts for 40% of total building energy usage. In central heating systems, heat is often transferred from heat source to users by the heat network where several heat exchangers are installed at heat source, substations and terminals respectively. For given overall heating capacity and heat source temperature, increasing the terminal fluid temperature is an effective way to improve the thermal performance of such cascade heat exchange network for energy saving. In this paper, the mathematical optimization model of the cascade heat exchange network with three-stage heat exchangers in series is established. Aim at maximizing the cold fluid temperature for given hot fluid temperature and overall heating capacity, the optimal heat exchange area distribution and the medium fluids' flow rates are determined through inverse problem and variation method. The preliminary results show that the heat exchange areas should be distributed equally for each heat exchanger. It also indicates that in order to improve the thermal performance of the whole system, more heat exchange areas should be allocated to the heat exchanger where flow rate difference between two fluids is relatively small. This work is important for guiding the optimization design of practical cascade heating systems.

Pharmaceutical development and optimization of azithromycin suppository for paediatric use.

PubMed

Kauss, Tina; Gaubert, Alexandra; Boyer, Chantal; Ba, Boubakar B; Manse, Muriel; Massip, Stephane; Léger, Jean-Michel; Fawaz, Fawaz; Lembege, Martine; Boiron, Jean-Michel; Lafarge, Xavier; Lindegardh, Niklas; White, Nicholas J; Olliaro, Piero; Millet, Pascal; Gaudin, Karen

2013-01-30

Pharmaceutical development and manufacturing process optimization work was undertaken in order to propose a potential paediatric rectal formulation of azithromycin as an alternative to existing oral or injectable formulations. The target product profile was to be easy-to-use, cheap and stable in tropical conditions, with bioavailability comparable to oral forms, rapidly achieving and maintaining bactericidal concentrations. PEG solid solution suppositories were characterized in vitro using visual, HPLC, DSC, FTIR and XRD analyses. In vitro drug release and in vivo bioavailability were assessed; a study in rabbits compared the bioavailability of the optimized solid solution suppository to rectal solution and intra-venous product (as reference) and to the previous, non-optimized formulation (suspended azithromycin suppository). The bioavailability of azithromycin administered as solid solution suppositories relative to intra-venous was 43%, which compared well to the target of 38% (oral product in humans). The results of 3-month preliminary stability and feasibility studies were consistent with industrial production scale-up. This product has potential both as a classical antibiotic and as a product for use in severely ill children in rural areas. Industrial partners for further development are being sought. Copyright © 2012 Elsevier B.V. All rights reserved.

Pharmaceutical development and optimization of azithromycin suppository for paediatric use

PubMed Central

Kauss, Tina; Gaubert, Alexandra; Boyer, Chantal; Ba, Boubakar B.; Manse, Muriel; Massip, Stephane; Léger, Jean-Michel; Fawaz, Fawaz; Lembege, Martine; Boiron, Jean-Michel; Lafarge, Xavier; Lindegardh, Niklas; White, Nicholas J.; Olliaro, Piero; Millet, Pascal; Gaudin, Karen

2013-01-01

Pharmaceutical development and manufacturing process optimization work was undertaken in order to propose a potential paediatric rectal formulation of azithromycin as an alternative to existing oral or injectable formulations. The target product profile was to be easy-to-use, cheap and stable in tropical conditions, with bioavailability comparable to oral forms, rapidly achieving and maintaining bactericidal concentrations. PEG solid solution suppositories were characterized in vitro using visual, HPLC, DSC, FTIR and XRD analyses. In vitro drug release and in vivo bioavailability were assessed; a study in rabbits compared the bioavailability of the optimized solid solution suppository to rectal solution and intra-venous product (as reference) and to the previous, non-optimized formulation (suspended azithromycin suppository). The bioavailability of azithromycin administered as solid solution suppositories relative to intra-venous was 43%, which compared well to the target of 38% (oral product in humans). The results of 3-month preliminary stability and feasibility studies were consistent with industrial production scale-up. This product has potential both as a classical antibiotic and as a product for use in severely ill children in rural areas. Industrial partners for further development are being sought. PMID:23220079

Runway Scheduling Using Generalized Dynamic Programming

NASA Technical Reports Server (NTRS)

Montoya, Justin; Wood, Zachary; Rathinam, Sivakumar

2011-01-01

A generalized dynamic programming method for finding a set of pareto optimal solutions for a runway scheduling problem is introduced. The algorithm generates a set of runway fight sequences that are optimal for both runway throughput and delay. Realistic time-based operational constraints are considered, including miles-in-trail separation, runway crossings, and wake vortex separation. The authors also model divergent runway takeoff operations to allow for reduced wake vortex separation. A modeled Dallas/Fort Worth International airport and three baseline heuristics are used to illustrate preliminary benefits of using the generalized dynamic programming method. Simulated traffic levels ranged from 10 aircraft to 30 aircraft with each test case spanning 15 minutes. The optimal solution shows a 40-70 percent decrease in the expected delay per aircraft over the baseline schedulers. Computational results suggest that the algorithm is promising for real-time application with an average computation time of 4.5 seconds. For even faster computation times, two heuristics are developed. As compared to the optimal, the heuristics are within 5% of the expected delay per aircraft and 1% of the expected number of runway operations per hour ad can be 100x faster.

Mission Design and Optimal Asteroid Deflection for Planetary Defense

NASA Technical Reports Server (NTRS)

Sarli, Bruno V.; Knittel, Jeremy M.; Englander, Jacob A.; Barbee, Brent W.

2017-01-01

Planetary defense is a topic of increasing interest for many reasons, which has been mentioned in "Vision and Voyages for Planetary Science in the Decade 2013-2022''. However, perhaps one of the most significant rationales for asteroid studies is the number of close approaches that have been documented recently. A space mission with a planetary defense objective aims to deflect the threatening body as far as possible from Earth. The design of a mission that optimally deflects an asteroid has different challenges: speed, precision, and system trade-off. This work addresses such issues and develops a fast transcription of the problem that can be implemented into an optimization tool, which allows for a broader trade study of different mission concepts with a medium fidelity. Such work is suitable for a mission?s preliminary study. It is shown, using the fictitious asteroid impact scenario 2017 PDC, that the complete tool is able to account for the orbit sensitivity to small perturbations and quickly optimize a deflection trajectory. The speed in which the tool operates allows for a trade study between the available hardware. As a result, key deflection dates and mission strategies are identified for the 2017 PDC.

Mission Design and Optimal Asteroid Deflection for Planetary Defense

NASA Technical Reports Server (NTRS)

Sarli, Bruno V.; Knittel, Jeremy M.; Englander, Jacob A.; Barbee, Brent W.

2017-01-01

Planetary defense is a topic of increasing interest for many reasons, which has been mentioned in "Vision and Voyages for Planetary Science in the Decade 2013-2022". However, perhaps one of the most significant rationales for asteroid studies is the number of close approaches that have been documented recently. A space mission with a planetary defense objective aims to deflect the threatening body as far as possible from Earth. The design of a mission that optimally deflects an asteroid has different challenges: speed, precision, and system trade-off. This work addresses such issues and develops a fast transcription of the problem that can be implemented into an optimization tool, which allows for a broader trade study of different mission concepts with a medium fidelity. Such work is suitable for a mission's preliminary study. It is shown, using the fictitious asteroid impact scenario 2017 PDC, that the complete tool is able to account for the orbit sensitivity to small perturbations and quickly optimize a deflection trajectory. The speed in which the tool operates allows for a trade study between the available hardware. As a result, key deflection dates and mission strategies are identified for the 2017 PDC.

Optimizing Industrial Consumer Demand Response Through Disaggregation, Hour-Ahead Pricing, and Momentary Autonomous Control

NASA Astrophysics Data System (ADS)

Abdulaal, Ahmed

The work in this study addresses the current limitations of the price-driven demand response (DR) approach. Mainly, the dependability on consumers to respond in an energy aware conduct, the response timeliness, the difficulty of applying DR in a busy industrial environment, and the problem of load synchronization are of utmost concern. In order to conduct a simulation study, realistic price simulation model and consumers' building load models are created using real data. DR action is optimized using an autonomous control method, which eliminates the dependency on frequent consumer engagement. Since load scheduling and long-term planning approaches are infeasible in the industrial environment, the proposed method utilizes instantaneous DR in response to hour-ahead price signals (RTP-HA). Preliminary simulation results concluded savings at the consumer-side at the cost of increased supplier-side burden due to the aggregate effect of the universal DR policies. Therefore, a consumer disaggregation strategy is briefly discussed. Finally, a refined discrete-continuous control system is presented, which utilizes multi-objective Pareto optimization, evolutionary programming, utility functions, and bidirectional loads. Demonstrated through a virtual testbed fit with real data, the new system achieves momentary optimized DR in real-time while maximizing the consumer's wellbeing.

Central Composite Design Optimization of Zinc Removal from Contaminated Soil, Using Citric Acid as Biodegradable Chelant.

PubMed

Asadzadeh, Farrokh; Maleki-Kaklar, Mahdi; Soiltanalinejad, Nooshin; Shabani, Farzin

2018-02-08

Citric acid (CA) was evaluated in terms of its efficiency as a biodegradable chelating agent, in removing zinc (Zn) from heavily contaminated soil, using a soil washing process. To determine preliminary ranges of variables in the washing process, single factor experiments were carried out with different CA concentrations, pH levels and washing times. Optimization of batch washing conditions followed using a response surface methodology (RSM) based central composite design (CCD) approach. CCD predicted values and experimental results showed strong agreement, with an R 2 value of 0.966. Maximum removal of 92.8% occurred with a CA concentration of 167.6 mM, pH of 4.43, and washing time of 30 min as optimal variable values. A leaching column experiment followed, to examine the efficiency of the optimum conditions established by the CCD model. A comparison of two soil washing techniques indicated that the removal efficiency rate of the column experiment (85.8%) closely matching that of the batch experiment (92.8%). The methodology supporting the research experimentation for optimizing Zn removal may be useful in the design of protocols for practical engineering soil decontamination applications.

Method of interplanetary trajectory optimization for the spacecraft with low thrust and swing-bys

NASA Astrophysics Data System (ADS)

Konstantinov, M. S.; Thein, M.

2017-07-01

The method developed to avoid the complexity of solving the multipoint boundary value problem while optimizing interplanetary trajectories of the spacecraft with electric propulsion and a sequence of swing-bys is presented in the paper. This method is based on the use of the preliminary problem solutions for the impulsive trajectories. The preliminary problem analyzed at the first stage of the study is formulated so that the analysis and optimization of a particular flight path is considered as the unconstrained minimum in the space of the selectable parameters. The existing methods can effectively solve this problem and make it possible to identify rational flight paths (the sequence of swing-bys) to receive the initial approximation for the main characteristics of the flight path (dates, values of the hyperbolic excess velocity, etc.). These characteristics can be used to optimize the trajectory of the spacecraft with electric propulsion. The special feature of the work is the introduction of the second (intermediate) stage of the research. At this stage some characteristics of the analyzed flight path (e.g. dates of swing-bys) are fixed and the problem is formulated so that the trajectory of the spacecraft with electric propulsion is optimized on selected sites of the flight path. The end-to-end optimization is carried out at the third (final) stage of the research. The distinctive feature of this stage is the analysis of the full set of optimal conditions for the considered flight path. The analysis of the characteristics of the optimal flight trajectories to Jupiter with Earth, Venus and Mars swing-bys for the spacecraft with electric propulsion are presented. The paper shows that the spacecraft weighing more than 7150 kg can be delivered into the vicinity of Jupiter along the trajectory with two Earth swing-bys by use of the space transportation system based on the "Angara A5" rocket launcher, the chemical upper stage "KVTK" and the electric propulsion system with input electrical power of 100 kW.

Applications of numerical optimization methods to helicopter design problems: A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1984-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Applications of numerical optimization methods to helicopter design problems - A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1985-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Applications of numerical optimization methods to helicopter design problems - A survey

NASA Technical Reports Server (NTRS)

Miura, H.

1984-01-01

A survey of applications of mathematical programming methods is used to improve the design of helicopters and their components. Applications of multivariable search techniques in the finite dimensional space are considered. Five categories of helicopter design problems are considered: (1) conceptual and preliminary design, (2) rotor-system design, (3) airframe structures design, (4) control system design, and (5) flight trajectory planning. Key technical progress in numerical optimization methods relevant to rotorcraft applications are summarized.

Fabrication of Thermoplastic Composite Laminates Having Film Interleaves By Automated Fiber Placement

NASA Technical Reports Server (NTRS)

Hulcher, A. B.; Tiwari, S. N.; Marchello, J. M.; Johnston, Norman J. (Technical Monitor)

2001-01-01

Experiments were carried out at the NASA Langley Research Center automated Fiber placement facility to determine an optimal process for the fabrication of composite materials having polymer film interleaves. A series of experiments was conducted to determine an optimal process for the composite prior to investigation of a process to fabricate laminates with polymer films. The results of the composite tests indicated that a well-consolidated, void-free laminate could be attained. Preliminary interleaf processing trials were then conducted to establish some broad guidelines for film processing. The primary finding of these initial studies was that a two-stage process was necessary in order to process these materials adequately. A screening experiment was then performed to determine the relative influence of the process variables on the quality of the film interface as determined by the wedge peel test method. Parameters that were found to be of minor influence on specimen quality were subsequently held at fixed values enabling a more rapid determination of an optimal process. Optimization studies were then performed by varying the remaining parameters at three film melt processing rates. The resulting peel data were fitted with quadratic response surfaces. Additional specimens were fabricated at levels of high peel strength as predicted by the regression models in an attempt to gage the accuracy of the predicted response and to assess the repeatability of the process. The overall results indicate that quality laminates having film interleaves can be successfully and repeatably fabricated by automated fiber placement.

X-Ray Imaging Applied to Problems in Planetary Materials

NASA Technical Reports Server (NTRS)

Jurewicz, A. J. G.; Mih, D. T.; Jones, S. M.; Connolly, H.

2000-01-01

Real-time radiography (X-ray imaging) can be a useful tool for tasks such as (1) the non-destructive, preliminary examination of opaque samples and (2) optimizing how to section opaque samples for more traditional microscopy and chemical analysis.

Diagnostics and Optimization of a Miniature High Frequency Pulse Tube Cryocooler

NASA Astrophysics Data System (ADS)

Garaway, I.; Veprik, A.; Radebaugh, R.

2010-04-01

A miniature, high energy density, pulse tube cryocooler with an inertance tube and reservoir has been developed, tested, diagnosed and optimized to provide appropriate cooling for size-limited cryogenic applications demanding fast cool down. This cryocooler, originally designed using REGEN 3.2 for 80 K, an operating frequency of 150 Hz and an average pressure of 5.0 MPa, has regenerator dimensions of 4.4 mm inside diameter and 27 mm length and is filled with ♯635 mesh stainless steel screen. Various design features, such as the use of compact heat exchangers and a miniature linear compressor, resulted in a remarkably compact pulse tube cryocooler. In this report, we present the preliminary test results and the subsequent diagnostic and optimization sequence performed to improve the overall design and operation of the complete cryocooler. These experimentally determined optimal parameters, though slightly different from those proposed in the initial numerical model, yielded 530 mW of gross cooling power at 120 K with an input electrical power of only 25 W. This study highlights the need to further establish our understanding of miniature, high frequency, regenerative cryocoolers, not only as a collection of independent subcomponents, but as one single working unit. It has also led to a list of additional improvements that may yet be made to even further improve the operating characteristics of such a complete miniature cryocooler.

Absorbable energy monitoring scheme: new design protocol to test vehicle structural crashworthiness.

PubMed

Ofochebe, Sunday M; Enibe, Samuel O; Ozoegwu, Chigbogu G

2016-05-01

In vehicle crashworthiness design optimization detailed system evaluation capable of producing reliable results are basically achieved through high-order numerical computational (HNC) models such as the dynamic finite element model, mesh-free model etc. However the application of these models especially during optimization studies is basically challenged by their inherent high demand on computational resources, conditional stability of the solution process, and lack of knowledge of viable parameter range for detailed optimization studies. The absorbable energy monitoring scheme (AEMS) presented in this paper suggests a new design protocol that attempts to overcome such problems in evaluation of vehicle structure for crashworthiness. The implementation of the AEMS involves studying crash performance of vehicle components at various absorbable energy ratios based on a 2DOF lumped-mass-spring (LMS) vehicle impact model. This allows for prompt prediction of useful parameter values in a given design problem. The application of the classical one-dimensional LMS model in vehicle crash analysis is further improved in the present work by developing a critical load matching criterion which allows for quantitative interpretation of the results of the abstract model in a typical vehicle crash design. The adequacy of the proposed AEMS for preliminary vehicle crashworthiness design is demonstrated in this paper, however its extension to full-scale design-optimization problem involving full vehicle model that shows greater structural detail requires more theoretical development.

Coping with occupational stress: the role of optimism and coping flexibility.

PubMed

Reed, Daniel J

2016-01-01

The current study aimed at measuring whether coping flexibility is a reliable and valid construct in a UK sample and subsequently investigating the association between coping flexibility, optimism, and psychological health - measured by perceived stress and life satisfaction. A UK university undergraduate student sample (N=95) completed an online questionnaire. The study is among the first to examine the validity and reliability of the English version of a scale measuring coping flexibility in a Western population and is also the first to investigate the association between optimism and coping flexibility. The results revealed that the scale had good reliability overall; however, factor analysis revealed no support for the existing two-factor structure of the scale. Coping flexibility and optimism were found to be strongly correlated, and hierarchical regression analyses revealed that the interaction between them predicted a large proportion of the variance in both perceived stress and life satisfaction. In addition, structural equation modeling revealed that optimism completely mediated the relationship between coping flexibility and both perceived stress and life satisfaction. The findings add to the occupational stress literature to further our understanding of how optimism is important in psychological health. Furthermore, given that optimism is a personality trait, and consequently relatively stable, the study also provides preliminary support for the potential of targeting coping flexibility to improve psychological health in Western populations. These findings must be replicated, and further analyses of the English version of the Coping Flexibility Scale are needed.

Vector-model-supported optimization in volumetric-modulated arc stereotactic radiotherapy planning for brain metastasis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Eva Sau Fan; Department of Health Technology and Informatics, The Hong Kong Polytechnic University; Wu, Vincent Wing Cheung

Long planning time in volumetric-modulated arc stereotactic radiotherapy (VMA-SRT) cases can limit its clinical efficiency and use. A vector model could retrieve previously successful radiotherapy cases that share various common anatomic features with the current case. The prsent study aimed to develop a vector model that could reduce planning time by applying the optimization parameters from those retrieved reference cases. Thirty-six VMA-SRT cases of brain metastasis (gender, male [n = 23], female [n = 13]; age range, 32 to 81 years old) were collected and used as a reference database. Another 10 VMA-SRT cases were planned with both conventional optimization and vector-model-supported optimization, followingmore » the oncologists' clinical dose prescriptions. Planning time and plan quality measures were compared using the 2-sided paired Wilcoxon signed rank test with a significance level of 0.05, with positive false discovery rate (pFDR) of less than 0.05. With vector-model-supported optimization, there was a significant reduction in the median planning time, a 40% reduction from 3.7 to 2.2 hours (p = 0.002, pFDR = 0.032), and for the number of iterations, a 30% reduction from 8.5 to 6.0 (p = 0.006, pFDR = 0.047). The quality of plans from both approaches was comparable. From these preliminary results, vector-model-supported optimization can expedite the optimization of VMA-SRT for brain metastasis while maintaining plan quality.« less

Effect of oxygen mass transfer rate on the production of 2,3-butanediol from glucose and agro-industrial byproducts by Bacillus licheniformis ATCC9789.

PubMed

Rebecchi, Stefano; Pinelli, Davide; Zanaroli, Giulio; Fava, Fabio; Frascari, Dario

2018-01-01

2,3-Butanediol (BD) is a largely used fossil-based platform chemical. The yield and productivity of bio-based BD fermentative production must be increased and cheaper substrates need to be identified, to make bio-based BD production more competitive. As BD bioproduction occurs under microaerobic conditions, a fine tuning and control of the oxygen transfer rate (OTR) is crucial to maximize BD yield and productivity. Very few studies on BD bioproduction focused on the use of non-pathogenic microorganisms and of byproducts as substrate. The goal of this work was to optimize BD bioproduction by the non-pathogenic strain Bacillus licheniformis ATCC9789 by (i) identifying the ranges of volumetric and biomass-specific OTR that maximize BD yield and productivity using standard sugar and protein sources, and (ii) performing a preliminary evaluation of the variation in process performances and cost resulting from the replacement of glucose with molasses, and beef extract/peptone with chicken meat and bone meal, a byproduct of the meat production industry. OTR optimization with an expensive, standard medium containing glucose, beef extract and peptone revealed that OTRs in the 7-15 mmol/L/h range lead to an optimal BD yield (0.43 ± 0.03 g/g) and productivity (0.91 ± 0.05 g/L/h). The corresponding optimal range of biomass-specific OTR was equal to 1.4-7.9 [Formula: see text], whereas the respiratory quotient ranged from 1.8 to 2.5. The switch to an agro-industrial byproduct-based medium containing chicken meat and bone meal and molasses led to a 50% decrease in both BD yield and productivity. A preliminary economic analysis indicated that the use of the byproduct-based medium can reduce by about 45% the BD production cost. A procedure for OTR optimization was developed and implemented, leading to the identification of a range of biomass-specific OTR and respiratory quotient to be used for the scale-up and control of BD bioproduction by Bacillus licheniformis . The switch to a byproduct-based medium led to a relevant decrease in BD production cost. Further research is needed to optimize the process of BD bioproduction from the tested byproduct-based medium.

How Much Can We Learn from a Single Chromatographic Experiment? A Bayesian Perspective.

PubMed

Wiczling, Paweł; Kaliszan, Roman

2016-01-05

In this work, we proposed and investigated a Bayesian inference procedure to find the desired chromatographic conditions based on known analyte properties (lipophilicity, pKa, and polar surface area) using one preliminary experiment. A previously developed nonlinear mixed effect model was used to specify the prior information about a new analyte with known physicochemical properties. Further, the prior (no preliminary data) and posterior predictive distribution (prior + one experiment) were determined sequentially to search towards the desired separation. The following isocratic high-performance reversed-phase liquid chromatographic conditions were sought: (1) retention time of a single analyte within the range of 4-6 min and (2) baseline separation of two analytes with retention times within the range of 4-10 min. The empirical posterior Bayesian distribution of parameters was estimated using the "slice sampling" Markov Chain Monte Carlo (MCMC) algorithm implemented in Matlab. The simulations with artificial analytes and experimental data of ketoprofen and papaverine were used to test the proposed methodology. The simulation experiment showed that for a single and two randomly selected analytes, there is 97% and 74% probability of obtaining a successful chromatogram using none or one preliminary experiment. The desired separation for ketoprofen and papaverine was established based on a single experiment. It was confirmed that the search for a desired separation rarely requires a large number of chromatographic analyses at least for a simple optimization problem. The proposed Bayesian-based optimization scheme is a powerful method of finding a desired chromatographic separation based on a small number of preliminary experiments.

In-Space Radiator Shape Optimization using Genetic Algorithms

NASA Technical Reports Server (NTRS)

Hull, Patrick V.; Kittredge, Ken; Tinker, Michael; SanSoucie, Michael

2006-01-01

Future space exploration missions will require the development of more advanced in-space radiators. These radiators should be highly efficient and lightweight, deployable heat rejection systems. Typical radiators for in-space heat mitigation commonly comprise a substantial portion of the total vehicle mass. A small mass savings of even 5-10% can greatly improve vehicle performance. The objective of this paper is to present the development of detailed tools for the analysis and design of in-space radiators using evolutionary computation techniques. The optimality criterion is defined as a two-dimensional radiator with a shape demonstrating the smallest mass for the greatest overall heat transfer, thus the end result is a set of highly functional radiator designs. This cross-disciplinary work combines topology optimization and thermal analysis design by means of a genetic algorithm The proposed design tool consists of the following steps; design parameterization based on the exterior boundary of the radiator, objective function definition (mass minimization and heat loss maximization), objective function evaluation via finite element analysis (thermal radiation analysis) and optimization based on evolutionary algorithms. The radiator design problem is defined as follows: the input force is a driving temperature and the output reaction is heat loss. Appropriate modeling of the space environment is added to capture its effect on the radiator. The design parameters chosen for this radiator shape optimization problem fall into two classes, variable height along the width of the radiator and a spline curve defining the -material boundary of the radiator. The implementation of multiple design parameter schemes allows the user to have more confidence in the radiator optimization tool upon demonstration of convergence between the two design parameter schemes. This tool easily allows the user to manipulate the driving temperature regions thus permitting detailed design of in-space radiators for unique situations. Preliminary results indicate an optimized shape following that of the temperature distribution regions in the "cooler" portions of the radiator. The results closely follow the expected radiator shape.

Optimal Decision-making Model of Integrated Water Resources Management - A Case of Hsinchu Water Resources Management

NASA Astrophysics Data System (ADS)

Wang, S. Y.; Ho, C. C.; Chang, L. C.

2017-12-01

The public use water in Hsinchu are mainly supplied from Baoshan Reservoir, Second Baoshan Reservoir, Yongheshan Reservoir and Longen Weir. However, the increasing water demand, caused by development of the Hsinchu Science and Industrial Park, results in supply stable water getting more difficult. For stabilize water supply in Hsinchu, the study applies long-term and short-term plans to fulfill the water shortage. Developing an efficient methodology to define a cost-effective action portfolio is an important task. Hence, the study develops a novel decision model, the Stochastic Programming with Recourse Decision Model (SPRDM), to estimate a cost-effective action portfolio. The first-stage of SPRDM determine the long-term action portfolio and the portfolio accompany recourse information (the probability for water shortage event). The second-stage of SPRDM optimize the cost-effective action portfolio in response to the recourse information. In order to consider the uncertainty of reservoir sediment and demand growth, the study set 9 scenarios comprise optimistic, most likely, and pessimistic reservoir sediment and demand growth. The results show the optimal action portfolio consist of FengTain Lake and Panlon Weir, Hsinchu Desalination Plant, Domestic and Industrial Water long-term plans, and Emergency Backup Well, Irrigation Water Transference, Preliminary Water Rationing, Advanced Water Rationing and Water Transport from Other Districts short-term plans. The minimum expected cost of optimal action portfolio is NT$1.1002 billion. The results can be used as a reference for decision making because the results have considered the uncertainty of varied hydrology, reservoir sediment, and water demand growth.

Rapid design and optimization of low-thrust rendezvous/interception trajectory for asteroid deflection missions

NASA Astrophysics Data System (ADS)

Li, Shuang; Zhu, Yongsheng; Wang, Yukai

2014-02-01

Asteroid deflection techniques are essential in order to protect the Earth from catastrophic impacts by hazardous asteroids. Rapid design and optimization of low-thrust rendezvous/interception trajectories is considered as one of the key technologies to successfully deflect potentially hazardous asteroids. In this paper, we address a general framework for the rapid design and optimization of low-thrust rendezvous/interception trajectories for future asteroid deflection missions. The design and optimization process includes three closely associated steps. Firstly, shape-based approaches and genetic algorithm (GA) are adopted to perform preliminary design, which provides a reasonable initial guess for subsequent accurate optimization. Secondly, Radau pseudospectral method is utilized to transcribe the low-thrust trajectory optimization problem into a discrete nonlinear programming (NLP) problem. Finally, sequential quadratic programming (SQP) is used to efficiently solve the nonlinear programming problem and obtain the optimal low-thrust rendezvous/interception trajectories. The rapid design and optimization algorithms developed in this paper are validated by three simulation cases with different performance indexes and boundary constraints.

Optimization of chlorine fluxing process for magnesium removal from molten aluminum

NASA Astrophysics Data System (ADS)

Fu, Qian

High-throughput and low operational cost are the keys to a successful industrial process. Much aluminum is now recycled in the form of used beverage cans and this aluminum is of alloys that contain high levels of magnesium. It is common practice to "demag" the metal by injecting chlorine that preferentially reacts with the magnesium. In the conventional chlorine fluxing processes, low reaction efficiency results in excessive reactive gas emissions. In this study, through an experimental investigation of the reaction kinetics involved in this process, a mathematical model is set up for the purpose of process optimization. A feedback controlled chlorine reduction process strategy is suggested for demagging the molten aluminum to the desired magnesium level without significant gas emissions. This strategy also needs the least modification of the existing process facility. The suggested process time will only be slightly longer than conventional methods and chlorine usage and emissions will be reduced. In order to achieve process optimization through novel designs in any fluxing process, a system is necessary for measuring the bubble distribution in liquid metals. An electro-resistivity probe described in the literature has low accuracy and its capability to measure bubble distribution has not yet been fully demonstrated. A capacitance bubble probe was designed for bubble measurements in molten metals. The probe signal was collected and processed digitally. Higher accuracy was obtained by higher discrimination against corrupted signals. A single-size bubble experiment in Belmont metal was designed to reveal the characteristic response of the capacitance probe. This characteristic response fits well with a theoretical model. It is suggested that using a properly designed deconvolution process, the actual bubble size distribution can be calculated. The capacitance probe was used to study some practical bubble generation devices. Preliminary results on bubble distribution generated by a porous plug in Belmont metal showed bubbles much bigger than those in a water model. Preliminary results in molten aluminum showed that the probe was applicable in this harsh environment. An interesting bubble coalescence phenomenon was also observed in both Belmont metal and molten aluminum.

Automatic picker of P & S first arrivals and robust event locator

NASA Astrophysics Data System (ADS)

Pinsky, V.; Polozov, A.; Hofstetter, A.

2003-12-01

We report on further development of automatic all distances location procedure designed for a regional network. The procedure generalizes the previous "loca l" (R < 500 km) and "regional" (500 < R < 2000 km) routines and comprises: a) preliminary data processing (filtering and de-spiking), b) phase identificatio n, c) P, S first arrival picking, d) preliminary location and e) robust grid-search optimization procedure. Innovations concern phase identification, automa tic picking and teleseismic location. A platform free flexible Java interface was recently created, allowing easy parameter tuning and on/off switching to t he full-scale manual picking mode. Identification of the regional P and S phase is provided by choosing between the two largest peaks in the envelope curve. For automatic on-time estimation we utilize now ratio of two STAs, calculated in two consecutive and equal time windows (instead of previously used Akike Information Criterion). "Teleseismic " location is split in two stages: preliminary and final one. The preliminary part estimates azimuth and apparent velocity by fitting a plane wave to the P automatic pickings. The apparent velocity criterion is used to decide about strategy of the following computations: teleseismic or regional. The preliminary estimates of azimuth and apparent velocity provide starting value for the final teleseismic and regional location. Apparent velocity is used to get first a pproximation distance to the source on the basis of the P, Pn, Pg travel-timetables. The distance estimate together with the preliminary azimuth estimate provides first approximations of the source latitude and longitude via sine and cosine theorems formulated for the spherical triangle. Final location is based on robust grid-search optimization procedure, weighting the number of pickings that simultaneously fit the model travel times. The grid covers initial location and becomes finer while approaching true hypocenter. The target function is a sum of the bell-shaped characteristic functions, used to emphasize true pickings and eliminate outliers. The final solution is a grid point that provides maximum to the target function. The procedure was applied to a list of ML > 4 earthquakes recorded by the Israel Seismic Network (ISN) in the 1999-2002 time period. Most of them are badly constrained relative the network. However, the results of location with average normalized error relative bulletin solutions e=dr/R of 5% were obtained, in each of the distance ranges. The first version of the procedure was incorporated in the national Early Warning System in 2001. Recently, we started to send automatic Early Warn ing reports, to the EMSC Real Time Bulletin. Initially reported some teleseismic location discrepancies have been eliminated by introduction of station corrections.

Configuration evaluation and criteria plan. Volume 1: System trades study and design methodology plan (preliminary). Space Transportation Main Engine (STME) configuration study

NASA Technical Reports Server (NTRS)

Bair, E. K.

1986-01-01

The System Trades Study and Design Methodology Plan is used to conduct trade studies to define the combination of Space Shuttle Main Engine features that will optimize candidate engine configurations. This is accomplished by using vehicle sensitivities and engine parametric data to establish engine chamber pressure and area ratio design points for candidate engine configurations. Engineering analyses are to be conducted to refine and optimize the candidate configurations at their design points. The optimized engine data and characteristics are then evaluated and compared against other candidates being considered. The Evaluation Criteria Plan is then used to compare and rank the optimized engine configurations on the basis of cost.

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

PubMed

Zhang, Yiqun; Clark, Julie A; Connelly, Michele C; Zhu, Fangyi; Min, Jaeki; Guiguemde, W Armand; Pradhan, Anupam; Iyer, Lalitha; Furimsky, Anna; Gow, Jason; Parman, Toufan; El Mazouni, Farah; Phillips, Margaret A; Kyle, Dennis E; Mirsalis, Jon; Guy, R Kiplin

2012-05-10

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multidrug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization.

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

PubMed Central

Zhang, Yiqun; Clark, Julie A; Connelly, Michele C.; Zhu, Fangyi; Min, Jaeki; Guiguemde, W. Armand; Pradhan, Anupam; Iyer, Lalitha; Furimsky, Anna; Gow, Jason; Parman, Toufan; El Mazouni, Farah; Phillips, Margaret A.; Kyle, Dennis E.; Mirsalis, Jon; Guy, R. Kiplin

2012-01-01

Malaria is a protozoal parasitic disease that is widespread in tropical and subtropical regions of Africa, Asia, and the Americas and causes more than 800,000 deaths per year. The continuing emergence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new and effective antimalarial drugs. Our previous work has explored the preliminary structural optimization of 4(1H)-quinolone ester derivatives, a new series of antimalarials related to the endochins. Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability. These studies led to the development of orally efficacious antimalarials including quinolone analogue 20g, a promising candidate for further optimization. PMID:22435599

Design Sensitivity for a Subsonic Aircraft Predicted by Neural Network and Regression Models

NASA Technical Reports Server (NTRS)

Hopkins, Dale A.; Patnaik, Surya N.

2005-01-01

A preliminary methodology was obtained for the design optimization of a subsonic aircraft by coupling NASA Langley Research Center s Flight Optimization System (FLOPS) with NASA Glenn Research Center s design optimization testbed (COMETBOARDS with regression and neural network analysis approximators). The aircraft modeled can carry 200 passengers at a cruise speed of Mach 0.85 over a range of 2500 n mi and can operate on standard 6000-ft takeoff and landing runways. The design simulation was extended to evaluate the optimal airframe and engine parameters for the subsonic aircraft to operate on nonstandard runways. Regression and neural network approximators were used to examine aircraft operation on runways ranging in length from 4500 to 7500 ft.

Design optimization of gas generator hybrid propulsion boosters

NASA Technical Reports Server (NTRS)

Weldon, Vincent; Phillips, Dwight U.; Fink, Lawrence E.

1990-01-01

A methodology used in support of a contract study for NASA/MSFC to optimize the design of gas generator hybrid propulsion booster for uprating the National Space Transportation System (NSTS) is presented. The objective was to compare alternative configurations for this booster approach, optimizing each candidate concept on different bases, in order to develop data for a trade table on which a final decision was based. The methodology is capable of processing a large number of independent and dependent variables, adjusting the overall subsystems characteristics to arrive at a best compromise integrated design to meet various specified optimization criteria subject to selected constraints. For each system considered, a detailed weight statement was generated along with preliminary cost and reliability estimates.

78 FR 34644 - Stainless Steel Plate in Coils From Belgium: Preliminary Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... Coils From Belgium: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012 AGENCY... of the scope of the order, see the ``Decision Memorandum for the Preliminary Results of Antidumping... Preliminary Decision Memorandum are identical in content. Preliminary Results of the Review As a result of...

Development and preliminary validation of the physician support of skin self-examination scale.

PubMed

Coroiu, Adina; Moran, Chelsea; Garland, Rosalind; Körner, Annett

2018-05-01

Skin self-examination (SSE) is a crucial preventive health behaviour in melanoma survivors, as it facilitates early detection. Physician endorsement of SSE is important for the initiation and maintenance of this behaviour. This study focussed on the preliminary validation of a new nine-item measure assessing physician support of SSE in melanoma patients. English and French versions of this measure were administered to 188 patients diagnosed with melanoma in the context of a longitudinal study investigating predictors and facilitators of SSE. Structural validity was investigated using exploratory factor analysis conducted in Mplus and convergent and divergent validity was assessed using bivariate correlations conducted in spss. Results suggest that the scale is a unidimensional and reliable measure of physician support for SSE. Given the uncertainty regarding the optimal frequency of SSE for at-risk individuals, we recommend that future psychometric evaluations of this scale consider tailoring items according to the most up-to-date research on SSE effectiveness.

Preliminary Analysis of High-Flux RSG-GAS to Transmute Am-241 of PWR’s Spent Fuel in Asian Region

NASA Astrophysics Data System (ADS)

Budi Setiawan, M.; Kuntjoro, S.

2018-02-01

A preliminary study of minor actinides (MA) transmutation in the high flux profile RSG-GAS research reactor was performed, aiming at an optimal transmutation loading for present nuclear energy development. The MA selected in the analysis includes Am-241 discharged from pressurized water reactors (PWRs) in Asian region. Until recently, studies have been undertaken in various methods to reduce radiotoxicity from actinides in high-level waste. From the cell calculation using computer code SRAC2006, it is obtained that the target Am-241 which has a cross section of the thermal energy absorption in the region (group 8) is relatively large; it will be easily burned in the RSG-GAS reactor. Minor actinides of Am-241 which can be inserted in the fuel (B/T fuel) is 2.5 kg which is equivalent to Am-241 resulted from the partition of spent fuel from 2 units power reactors PWR with power 1000MW(th) operated for one year.

Preliminary Study of Gas Cooled Fast Breeder Reactor with Heterogen Percentage of Uranium-Plutonium Carbide based fuel and 300 MWt Power

NASA Astrophysics Data System (ADS)

Clief Pattipawaej, Sandro; Su'ud, Zaki

2017-01-01

A preliminary design study of GFR with helium gas-cooled has been performed. In this study used natural uranium and plutonium results LWR waste as fuel. Fuel with a small percentage of plutonium are arranged on the inside of the core area, and the fuel with a greater percentage set on the outside of the core area. The configuration of such fuel is deliberately set to increase breeding in this part of the central core and reduce the leakage of neutrons on the outer side of the core, in order to get long-lived reactor with a small reactivity. Configuration of fuel as it is also useful to generate a peak power reactors with relatively low in both the direction of axial or radial. Optimization has been done to fuel fraction 45.0% was found that the reactor may be operating in more than 10 year time with excess reactivity less than 1%.

Spin exchange optical pumping based polarized 3He filling station for the Hybrid Spectrometer at the Spallation Neutron Source.

PubMed

Jiang, C Y; Tong, X; Brown, D R; Culbertson, H; Graves-Brook, M K; Hagen, M E; Kadron, B; Lee, W T; Robertson, J L; Winn, B

2013-06-01

The Hybrid Spectrometer (HYSPEC) is a new direct geometry spectrometer at the Spallation Neutron Source at the Oak Ridge National Laboratory. This instrument is equipped with polarization analysis capability with 60° horizontal and 15° vertical detector coverages. In order to provide wide angle polarization analysis for this instrument, we have designed and built a novel polarized (3)He filling station based on the spin exchange optical pumping method. It is designed to supply polarized (3)He gas to HYSPEC as a neutron polarization analyzer. In addition, the station can optimize the (3)He pressure with respect to the scattered neutron energies. The depolarized (3)He gas in the analyzer can be transferred back to the station to be repolarized. We have constructed the prototype filling station. Preliminary tests have been carried out demonstrating the feasibility of the filling station. Here, we report on the design, construction, and the preliminary results of the prototype filling station.

76 FR 60491 - Mona South Pumped Storage Project; Notice of Preliminary Permit Application Accepted for Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-29

... efficiency; (7) optimization of generation and energy storage ranging from a 4 unit, 500 megawatts (MW) (4... brief comments up to 6,000 characters, without prior registration, using the eComment system at http...

Application of Rasch analysis to the parent adherence report questionnaire in juvenile idiopathic arthritis.

PubMed

Toupin April, Karine; Higgins, Johanne; Ehrmann Feldman, Debbie

2016-07-28

Adherence to treatment in children with juvenile idiopathic arthritis (JIA) is associated with better outcomes. Assessing patient adherence in JIA, as well as attitudes and beliefs about prescribed treatments, is important for the clinician in order to optimize patient management. The objective of the current study was to evaluate the psychometric properties of the Parent (proxy-report) Adherence Report Questionnaires (PARQ), which assesses beliefs and behaviors related to adherence to treatments prescribed for JIA. A Rasch analysis was conducted on data collected with parents of children with JIA from two studies in which the PARQ was used as a measure of adherence. The PARQ showed preliminary evidence of multidimensionality with two factors, accounting for 38 % and 27 % of the variance respectively. The PARQ in its original version does not adhere to expectations of the Rasch model. A transformed version of the PARQ obtained by deletion of the general adherence scale and modification of visual analog scales into 5-point likert scales improved fit to the model and showed preliminary evidence of unidimensionality. The PARQ was transformed based on the results of the Rasch analysis. The transformed version of the PARQ shows preliminary evidence of unidimensionality and may allow computation of a total score, although further testing is needed to verify these findings.

Image denoising by exploring external and internal correlations.

PubMed

Yue, Huanjing; Sun, Xiaoyan; Yang, Jingyu; Wu, Feng

2015-06-01

Single image denoising suffers from limited data collection within a noisy image. In this paper, we propose a novel image denoising scheme, which explores both internal and external correlations with the help of web images. For each noisy patch, we build internal and external data cubes by finding similar patches from the noisy and web images, respectively. We then propose reducing noise by a two-stage strategy using different filtering approaches. In the first stage, since the noisy patch may lead to inaccurate patch selection, we propose a graph based optimization method to improve patch matching accuracy in external denoising. The internal denoising is frequency truncation on internal cubes. By combining the internal and external denoising patches, we obtain a preliminary denoising result. In the second stage, we propose reducing noise by filtering of external and internal cubes, respectively, on transform domain. In this stage, the preliminary denoising result not only enhances the patch matching accuracy but also provides reliable estimates of filtering parameters. The final denoising image is obtained by fusing the external and internal filtering results. Experimental results show that our method constantly outperforms state-of-the-art denoising schemes in both subjective and objective quality measurements, e.g., it achieves >2 dB gain compared with BM3D at a wide range of noise levels.

Multidisciplinary optimization of a controlled space structure using 150 design variables

NASA Technical Reports Server (NTRS)

James, Benjamin B.

1992-01-01

A general optimization-based method for the design of large space platforms through integration of the disciplines of structural dynamics and control is presented. The method uses the global sensitivity equations approach and is especially appropriate for preliminary design problems in which the structural and control analyses are tightly coupled. The method is capable of coordinating general purpose structural analysis, multivariable control, and optimization codes, and thus, can be adapted to a variety of controls-structures integrated design projects. The method is used to minimize the total weight of a space platform while maintaining a specified vibration decay rate after slewing maneuvers.

Sequence Optimized Real-Time RT-PCR Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus

DTIC Science & Technology

2017-03-21

19-23]. Real-56 time reverse-transcription PCR remains the gold standard for quantitative , sensitive, and specific 57 detection of CCHFV; however...five-fold in two different series , and samples were run by real- time RT-PCR 116 in triplicate. The preliminary LOD was the lowest RNA dilution where...1 Sequence optimized real- time RT-PCR assay for detection of Crimean-Congo hemorrhagic fever 1 virus 2 3 JW Koehler1, KL Delp1, AT Hall1, SP

Trajectory optimization for the national aerospace plane

NASA Technical Reports Server (NTRS)

Lu, Ping

1993-01-01

During the past six months the research objectives outlined in the last semi-annual report were accomplished. Specifically, these are: three-dimensional (3-D) fuel-optimal ascent trajectory of the aerospace plane and the effects of thrust vectoring control (TVC) on the fuel consumption and trajectory shaping were investigated; the maximum abort landing area (footprint) was studied; preliminary assessment of simultaneous design of the ascent trajectory and the vehicle configuration for the aerospace plane was also conducted. The work accomplished in the reporting period is summarized.

Antireflective nanostructures for CPV

NASA Astrophysics Data System (ADS)

Buencuerpo, Jeronimo; Torne, Lorena; Alvaro, Raquel; Llorens, Jose Manuel; Dotor, María Luisa; Ripalda, Jose Maria

2017-09-01

We have optimized a periodic antireflective nanostructure. The optimal design has a theoretical broadband reflectivity of 0.54% on top of GaInP with an AlInP window layer. Preliminary fabrication attempts have been carried out on top of GaAs substrates. Due to the lack of a window layer, and the need to fine tune the fabrication process, the fabricated nanostructures have a reflectivity of 3.1%, but this is already significantly lower than the theoretical broadband reflectance of standard MgF2/ZnS bilayers (4.5%).

A Framework for Preliminary Design of Aircraft Structures Based on Process Information. Part 1

NASA Technical Reports Server (NTRS)

Rais-Rohani, Masoud

1998-01-01

This report discusses the general framework and development of a computational tool for preliminary design of aircraft structures based on process information. The described methodology is suitable for multidisciplinary design optimization (MDO) activities associated with integrated product and process development (IPPD). The framework consists of three parts: (1) product and process definitions; (2) engineering synthesis, and (3) optimization. The product and process definitions are part of input information provided by the design team. The backbone of the system is its ability to analyze a given structural design for performance as well as manufacturability and cost assessment. The system uses a database on material systems and manufacturing processes. Based on the identified set of design variables and an objective function, the system is capable of performing optimization subject to manufacturability, cost, and performance constraints. The accuracy of the manufacturability measures and cost models discussed here depend largely on the available data on specific methods of manufacture and assembly and associated labor requirements. As such, our focus in this research has been on the methodology itself and not so much on its accurate implementation in an industrial setting. A three-tier approach is presented for an IPPD-MDO based design of aircraft structures. The variable-complexity cost estimation methodology and an approach for integrating manufacturing cost assessment into design process are also discussed. This report is presented in two parts. In the first part, the design methodology is presented, and the computational design tool is described. In the second part, a prototype model of the preliminary design Tool for Aircraft Structures based on Process Information (TASPI) is described. Part two also contains an example problem that applies the methodology described here for evaluation of six different design concepts for a wing spar.

Design of a Vehicle Based Intervention System to Prevent Ozone Loss

NASA Technical Reports Server (NTRS)

Cole, Robin; Fisher, Daniel; Meade, Matt; Neel, James; Olson, Kristin; Pittman, Andrew; Valdivia, Anne; Wibisono, Aria; Mason, William H.; Kirschbaum, Nathan

1995-01-01

This project was designed to be completed over a period of three years. Overall project goals were: (1) To understand the processes that contribute to stratospheric ozone loss; (2) To determine the best prevention scheme for loss; (3) To design a delivery vehicle to accomplish the prevention scheme. The 1994-1995 design objectives included: (1) To review the results of the 1993-1994 design team, including a reevaluation of the major assumptions and criteria selected to choose a vehicle; (2) To evaluate preliminary vehicle concepts and perform quantitative trade studies to select the optimal vehicle concept.

A kicking simulator to investigate the foot-ball interaction during a rugby place kick.

PubMed

Minnaar, Nick; van den Heever, Dawie J

2015-01-01

Foot-ball interaction is an important aspect in rugby place kicking but has received very little attention in literature. This preliminary study presents an adjustable mechanical kicking simulator used to investigate different foot positions and orientations during the foot-ball interaction on resultant ball motion. It was found that changes in foot position and orientation during ball contact can have a large influence on ball motion. It is believed that with further research an optimal place-kicking technique can be found to maximize energy transfer to the ball while still maintaining accuracy.

Shortest path problem on a grid network with unordered intermediate points

NASA Astrophysics Data System (ADS)

Saw, Veekeong; Rahman, Amirah; Eng Ong, Wen

2017-10-01

We consider a shortest path problem with single cost factor on a grid network with unordered intermediate points. A two stage heuristic algorithm is proposed to find a feasible solution path within a reasonable amount of time. To evaluate the performance of the proposed algorithm, computational experiments are performed on grid maps of varying size and number of intermediate points. Preliminary results for the problem are reported. Numerical comparisons against brute forcing show that the proposed algorithm consistently yields solutions that are within 10% of the optimal solution and uses significantly less computation time.

Application of pattern recognition techniques to crime analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bender, C.F.; Cox, L.A. Jr.; Chappell, G.A.

1976-08-15

The initial goal was to evaluate the capabilities of current pattern recognition techniques when applied to existing computerized crime data. Performance was to be evaluated both in terms of the system's capability to predict crimes and to optimize police manpower allocation. A relation was sought to predict the crime's susceptibility to solution, based on knowledge of the crime type, location, time, etc. The preliminary results of this work are discussed. They indicate that automatic crime analysis involving pattern recognition techniques is feasible, and that efforts to determine optimum variables and techniques are warranted. 47 figures (RWR)

Front-end electronics for the LZ experiment

NASA Astrophysics Data System (ADS)

Morad, James; LZ Collaboration

2016-03-01

LZ is a second generation direct dark matter detection experiment with 5.6 tonnes of liquid xenon active target, which will be instrumented as a two-phase time projection chamber (TPC). The peripheral xenon outside the active TPC (``skin'') will also be instrumented. In addition, there will be a liquid scintillator based outer veto surrounding the main cryostat. All of these systems will be read out using photomultiplier tubes. I will present the designs for front-end electronics for all these systems, which have been optimized for shaping times, gains, and low noise. Preliminary results from prototype boards will also be presented.

Change in the Embedding Dimension as an Indicator of an Approaching Transition

PubMed Central

Neuman, Yair; Marwan, Norbert; Cohen, Yohai

2014-01-01

Predicting a transition point in behavioral data should take into account the complexity of the signal being influenced by contextual factors. In this paper, we propose to analyze changes in the embedding dimension as contextual information indicating a proceeding transitive point, called OPtimal Embedding tRANsition Detection (OPERAND). Three texts were processed and translated to time-series of emotional polarity. It was found that changes in the embedding dimension proceeded transition points in the data. These preliminary results encourage further research into changes in the embedding dimension as generic markers of an approaching transition point. PMID:24979691

High-sensitivity silicon nanowire phototransistors

NASA Astrophysics Data System (ADS)

Tan, Siew Li; Zhao, Xingyan; Dan, Yaping

2014-08-01

Silicon nanowires (SiNWs) have emerged as a promising material for high-sensitivity photodetection in the UV, visible and near-infrared spectral ranges. In this work, we demonstrate novel planar SiNW phototransistors on silicon-oninsulator (SOI) substrate using CMOS-compatible processes. The device consists of a bipolar transistor structure with an optically-injected base region. The electronic and optical properties of the SiNW phototransistors are investigated. Preliminary simulation and experimental results show that nanowire geometry, doping densities and surface states have considerable effects on the device performance, and that a device with optimized parameters can potentially outperform conventional Si photodetectors.

Pyrotechnic hazards classification and evaluation program. Run-up reaction testing in pyrotechnic dust suspensions

NASA Technical Reports Server (NTRS)

1971-01-01

A preliminary investigation of the parameters included in run-up dust reactions is presented. Two types of tests were conducted: (1) ignition criteria of large bulk pyrotechnic dusts, and (2) optimal run-up conditions of large bulk pyrotechnic dusts. These tests were used to evaluate the order of magnitude and gross scale requirements needed to induce run-up reactions in pyrotechnic dusts and to simulate at reduced scale an accident that occurred in a manufacturing installation. Test results showed that propagation of pyrotechnic dust clouds resulted in a fireball of relatively long duration and large size. In addition, a plane wave front was observed to travel down the length of the gallery.

[Determination of glutamic acid in biological material by capillary electrophoresis].

PubMed

Narezhnaya, E; Krukier, I; Avrutskaya, V; Degtyareva, A; Igumnova, E A

2015-01-01

The conditions for the identification and determination of Glutamic acid by capillary zone electrophoresis without their preliminary derivatization have been optimized. The effect of concentration of buffer electrolyte and pH on determination of Glutamic acid has been investigated. It is shown that the 5 Mm borate buffer concentration and a pH 9.15 are optimal. Quantitative determination of glutamic acid has been carried out using a linear dependence between the concentration of the analyte and the area of the peak. The accuracy and reproducibility of the determination are confirmed by the method "introduced - found". Glutamic acid has been determined in the placenta homogenate. The duration of analysis doesn't exceed 30 minutes. The results showed a decrease in the level of glutamic acid in cases of pregnancy complicated by placental insufficiency compared with the physiological, and this fact allows to consider the level of glutamic acid as a possible marker of complicated pregnancy.

Precision Neutron Time-of-Flight Detectors Provide Insight into NIF Implosion Dynamics

NASA Astrophysics Data System (ADS)

Schlossberg, David; Eckart, M. J.; Grim, G. P.; Hartouni, E. P.; Hatarik, R.; Moore, A. S.; Waltz, C. S.

2017-10-01

During inertial confinement fusion, higher-order moments of neutron time-of-flight (nToF) spectra can provide essential information for optimizing implosions. The nToF diagnostic suite at the National Ignition Facility (NIF) was recently upgraded to include novel, quartz Cherenkov detectors. These detectors exploit the rapid Cherenkov radiation process, in contrast with conventional scintillator decay times, to provide high temporal-precision measurements that support higher-order moment analyses. Preliminary measurements have been made on the NIF during several implosions and initial results are presented here. Measured line-of-sight asymmetries, for example in ion temperatures, will be discussed. Finally, advanced detector optimization is shown to advance accessible physics, with possibilities for energy discrimination, gamma source identification, and further reduction in quartz response times. Work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.

Navigation for space shuttle approach and landing using an inertial navigation system augmented by data from a precision ranging system or a microwave scan beam landing guidance system

NASA Technical Reports Server (NTRS)

Mcgee, L. A.; Smith, G. L.; Hegarty, D. M.; Merrick, R. B.; Carson, T. M.; Schmidt, S. F.

1970-01-01

A preliminary study has been made of the navigation performance which might be achieved for the high cross-range space shuttle orbiter during final approach and landing by using an optimally augmented inertial navigation system. Computed navigation accuracies are presented for an on-board inertial navigation system augmented (by means of an optimal filter algorithm) with data from two different ground navigation aids; a precision ranging system and a microwave scanning beam landing guidance system. These results show that augmentation with either type of ground navigation aid is capable of providing a navigation performance at touchdown which should be adequate for the space shuttle. In addition, adequate navigation performance for space shuttle landing is obtainable from the precision ranging system even with a complete dropout of precision range measurements as much as 100 seconds before touchdown.

Performance Trades Study for Robust Airfoil Shape Optimization

NASA Technical Reports Server (NTRS)

Li, Wu; Padula, Sharon

2003-01-01

From time to time, existing aircraft need to be redesigned for new missions with modified operating conditions such as required lift or cruise speed. This research is motivated by the needs of conceptual and preliminary design teams for smooth airfoil shapes that are similar to the baseline design but have improved drag performance over a range of flight conditions. The proposed modified profile optimization method (MPOM) modifies a large number of design variables to search for nonintuitive performance improvements, while avoiding off-design performance degradation. Given a good initial design, the MPOM generates fairly smooth airfoils that are better than the baseline without making drastic shape changes. Moreover, the MPOM allows users to gain valuable information by exploring performance trades over various design conditions. Four simulation cases of airfoil optimization in transonic viscous ow are included to demonstrate the usefulness of the MPOM as a performance trades study tool. Simulation results are obtained by solving fully turbulent Navier-Stokes equations and the corresponding discrete adjoint equations using an unstructured grid computational fluid dynamics code FUN2D.

Application of preconditioned alternating direction method of multipliers in depth from focal stack

NASA Astrophysics Data System (ADS)

Javidnia, Hossein; Corcoran, Peter

2018-03-01

Postcapture refocusing effect in smartphone cameras is achievable using focal stacks. However, the accuracy of this effect is totally dependent on the combination of the depth layers in the stack. The accuracy of the extended depth of field effect in this application can be improved significantly by computing an accurate depth map, which has been an open issue for decades. To tackle this issue, a framework is proposed based on a preconditioned alternating direction method of multipliers for depth from the focal stack and synthetic defocus application. In addition to its ability to provide high structural accuracy, the optimization function of the proposed framework can, in fact, converge faster and better than state-of-the-art methods. The qualitative evaluation has been done on 21 sets of focal stacks and the optimization function has been compared against five other methods. Later, 10 light field image sets have been transformed into focal stacks for quantitative evaluation purposes. Preliminary results indicate that the proposed framework has a better performance in terms of structural accuracy and optimization in comparison to the current state-of-the-art methods.

Development of X-TOOLSS: Preliminary Design of Space Systems Using Evolutionary Computation

NASA Technical Reports Server (NTRS)

Schnell, Andrew R.; Hull, Patrick V.; Turner, Mike L.; Dozier, Gerry; Alverson, Lauren; Garrett, Aaron; Reneau, Jarred

2008-01-01

Evolutionary computational (EC) techniques such as genetic algorithms (GA) have been identified as promising methods to explore the design space of mechanical and electrical systems at the earliest stages of design. In this paper the authors summarize their research in the use of evolutionary computation to develop preliminary designs for various space systems. An evolutionary computational solver developed over the course of the research, X-TOOLSS (Exploration Toolset for the Optimization of Launch and Space Systems) is discussed. With the success of early, low-fidelity example problems, an outline of work involving more computationally complex models is discussed.

Preliminary design of a mobile lunar power supply

NASA Technical Reports Server (NTRS)

Schmitz, Paul C.; Kenny, Barbara H.; Fulmer, Christopher R.

1991-01-01

A preliminary design for a Stirling isotope power system for use as a mobile lunar power supply is presented. Performance and mass of the components required for the system are estimated. These estimates are based on power requirements and the operating environment. Optimizations routines are used to determine minimum mass operational points. Shielding for the isotope system are given as a function of the allowed dose, distance from the source, and the time spent near the source. The technologies used in the power conversion and radiator systems are taken from ongoing research in the Civil Space Technology Initiative (CSTI) program.

Control of water distribution networks with dynamic DMA topology using strictly feasible sequential convex programming

NASA Astrophysics Data System (ADS)

Wright, Robert; Abraham, Edo; Parpas, Panos; Stoianov, Ivan

2015-12-01

The operation of water distribution networks (WDN) with a dynamic topology is a recently pioneered approach for the advanced management of District Metered Areas (DMAs) that integrates novel developments in hydraulic modeling, monitoring, optimization, and control. A common practice for leakage management is the sectorization of WDNs into small zones, called DMAs, by permanently closing isolation valves. This facilitates water companies to identify bursts and estimate leakage levels by measuring the inlet flow for each DMA. However, by permanently closing valves, a number of problems have been created including reduced resilience to failure and suboptimal pressure management. By introducing a dynamic topology to these zones, these disadvantages can be eliminated while still retaining the DMA structure for leakage monitoring. In this paper, a novel optimization method based on sequential convex programming (SCP) is outlined for the control of a dynamic topology with the objective of reducing average zone pressure (AZP). A key attribute for control optimization is reliable convergence. To achieve this, the SCP method we propose guarantees that each optimization step is strictly feasible, resulting in improved convergence properties. By using a null space algorithm for hydraulic analyses, the computations required are also significantly reduced. The optimized control is actuated on a real WDN operated with a dynamic topology. This unique experimental program incorporates a number of technologies set up with the objective of investigating pioneering developments in WDN management. Preliminary results indicate AZP reductions for a dynamic topology of up to 6.5% over optimally controlled fixed topology DMAs. This article was corrected on 12 JAN 2016. See the end of the full text for details.

The use of least squares methods in functional optimization of energy use prediction models

NASA Astrophysics Data System (ADS)

Bourisli, Raed I.; Al-Shammeri, Basma S.; AlAnzi, Adnan A.

2012-06-01

The least squares method (LSM) is used to optimize the coefficients of a closed-form correlation that predicts the annual energy use of buildings based on key envelope design and thermal parameters. Specifically, annual energy use is related to a number parameters like the overall heat transfer coefficients of the wall, roof and glazing, glazing percentage, and building surface area. The building used as a case study is a previously energy-audited mosque in a suburb of Kuwait City, Kuwait. Energy audit results are used to fine-tune the base case mosque model in the VisualDOE{trade mark, serif} software. Subsequently, 1625 different cases of mosques with varying parameters were developed and simulated in order to provide the training data sets for the LSM optimizer. Coefficients of the proposed correlation are then optimized using multivariate least squares analysis. The objective is to minimize the difference between the correlation-predicted results and the VisualDOE-simulation results. It was found that the resulting correlation is able to come up with coefficients for the proposed correlation that reduce the difference between the simulated and predicted results to about 0.81%. In terms of the effects of the various parameters, the newly-defined weighted surface area parameter was found to have the greatest effect on the normalized annual energy use. Insulating the roofs and walls also had a major effect on the building energy use. The proposed correlation and methodology can be used during preliminary design stages to inexpensively assess the impacts of various design variables on the expected energy use. On the other hand, the method can also be used by municipality officials and planners as a tool for recommending energy conservation measures and fine-tuning energy codes.

PRELIMINARY ASSESSMENT OF LIFE-CYCLE COSTS OF PROTECTIVE CLOTHING

EPA Science Inventory

Many different types of chemical protective clothing (CPC) are used to isolate workers at hazardous waste sites from contact with the potential hazards posed by chemical wastes. he goal in selecting the appropriate clothing for a particular occupational situation is to optimize w...

Designer's unified cost model

NASA Technical Reports Server (NTRS)

Freeman, William T.; Ilcewicz, L. B.; Swanson, G. D.; Gutowski, T.

1992-01-01

A conceptual and preliminary designers' cost prediction model has been initiated. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state of the art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a data base and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. The approach, goals, plans, and progress is presented for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

TU-EF-204-09: A Preliminary Method of Risk-Informed Optimization of Tube Current Modulation for Dose Reduction in CT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Y; Liu, B; Kalra, M

Purpose: X-rays from CT scans can increase cancer risk to patients. Lifetime Attributable Risk of Cancer Incidence for adult patients has been investigated and shown to decrease as patient age. However, a new risk model shows an increasing risk trend for several radiosensitive organs for middle age patients. This study investigates the feasibility of a general method for optimizing tube current modulation (TCM) functions to minimize risk by reducing radiation dose to radiosensitive organs of patients. Methods: Organ-based TCM has been investigated in literature for eye lens dose and breast dose. Adopting the concept in organ-based TCM, this study seeksmore » to find an optimized tube current for minimal total risk to breasts and lungs by reducing dose to these organs. The contributions of each CT view to organ dose are determined through simulations of CT scan view-by-view using a GPU-based fast Monte Carlo code, ARCHER. A Linear Programming problem is established for tube current optimization, with Monte Carlo results as weighting factors at each view. A pre-determined dose is used as upper dose boundary, and tube current of each view is optimized to minimize the total risk. Results: An optimized tube current is found to minimize the total risk of lungs and breasts: compared to fixed current, the risk is reduced by 13%, with breast dose reduced by 38% and lung dose reduced by 7%. The average tube current is maintained during optimization to maintain image quality. In addition, dose to other organs in chest region is slightly affected, with relative change in dose smaller than 10%. Conclusion: Optimized tube current plans can be generated to minimize cancer risk to lungs and breasts while maintaining image quality. In the future, various risk models and greater number of projections per rotation will be simulated on phantoms of different gender and age. National Institutes of Health R01EB015478.« less

Design of operating rules in complex water resources systems using historical records, expert criteria and fuzzy logic

NASA Astrophysics Data System (ADS)

Pulido-Velazquez, Manuel; Macian-Sorribes, Hector; María Benlliure-Moreno, Jose; Fullana-Montoro, Juan

2015-04-01

Water resources systems in areas with a strong tradition in water use are complex to manage by the high amount of constraints that overlap in time and space, creating a complicated framework in which past, present and future collide between them. In addition, it is usual to find "hidden constraints" in system operations, which condition operation decisions being unnoticed by anyone but the river managers and users. Being aware of those hidden constraints requires usually years of experience and a degree of involvement in that system's management operations normally beyond the possibilities of technicians. However, their impact in the management decisions is strongly imprinted in the historical data records available. The purpose of this contribution is to present a methodology capable of assessing operating rules in complex water resources systems combining historical records and expert criteria. Both sources are coupled using fuzzy logic. The procedure stages are: 1) organize expert-technicians preliminary meetings to let the first explain how they manage the system; 2) set up a fuzzy rule-based system (FRB) structure according to the way the system is managed; 3) use the historical records available to estimate the inputs' fuzzy numbers, to assign preliminary output values to the FRB rules and to train and validate these rules; 4) organize expert-technician meetings to discuss the rule structure and the input's quantification, returning if required to the second stage; 5) once the FRB structure is accepted, its output values must be refined and completed with the aid of the experts by using meetings, workshops or surveys; 6) combine the FRB with a Decision Support System (DSS) to simulate the effect of those management decisions; 7) compare its results with the ones offered by the historical records and/or simulation or optimization models; and 8) discuss with the stakeholders the model performance returning, if it's required, to the fifth or the second stage. The methodology proposed has been applied to the Jucar River Basin (Spain). This basin has 3 reservoirs, 4 headwaters, 11 demands and 5 environmental flows; which form together a complex constraint set. After the preliminary meetings, one 81-rule FRB was created, using as inputs the system state variables at the start of the hydrologic year, and as outputs the target reservoir release schedule. The inputs' fuzzy numbers were estimated jointly using surveys. Fifteen years of historical records were used to train the system's outputs. The obtained FRB was then refined during additional expert-technician meetings. After that, the resulting FRB was introduced into a DSS simulating the effect of those management rules for different hydrological conditions. Three additional FRB's were created using: 1) exclusively the historical records; 2) a stochastic optimization model; and 3) a deterministic optimization model. The results proved to be consistent with the expectations, with the stakeholder's FRB performance located between the data-driven simulation and the stochastic optimization FRB's; and reflect the stakeholders' major goals and concerns about the river management. ACKNOWLEDGEMENT: This study has been partially supported by the IMPADAPT project (CGL2013-48424-C2-1-R) with Spanish MINECO (Ministerio de Economía y Competitividad) funds.

Optimal policy for mitigating emissions in the European transport sector

NASA Astrophysics Data System (ADS)

Leduc, Sylvain; Piera, Patrizio; Sennai, Mesfun; Igor, Staritsky; Berien, Elbersen; Tijs, Lammens; Florian, Kraxner

2017-04-01

A geographic explicit techno-economic model, BeWhere (www.iiasa.ac.at/bewhere), has been developed at the European scale (Europe 28, the Balkans countries, Turkey, Moldavia and Ukraine) at a 40km grid size, to assess the potential of bioenergy from non-food feedstock. Based on the minimization of the supply chain from feedstock collection to the final energy product distribution, the model identifies the optimal bioenergy production plants in terms of spatial location, technology and capacity. The feedstock of interests are woody biomass (divided into eight types from conifers and non-conifers) and five different crop residuals. For each type of feedstock, one or multiple technologies can be applied for either heat, electricity or biofuel production. The model is run for different policy tools such as carbon cost, biofuel support, or subsidies, and the optimal mix of technologies and biomass needed is optimized to reach a production cost competitive against the actual reference system which is fossil fuel based. From this approach, the optimal mix of policy tools that can be applied country wide in Europe will be identified. The preliminary results show that high carbon tax and biofuel support contribute to the development of large scale biofuel production based on woody biomass plants mainly located in the northern part of Europe. Finally the highest emission reduction is reached with low biofuel support and high carbon tax evenly distributed in Europe.

A new method for optimization of low-thrust gravity-assist sequences

NASA Astrophysics Data System (ADS)

Maiwald, V.

2017-09-01

Recently missions like Hayabusa and Dawn have shown the relevance and benefits of low-thrust spacecraft concerning the exploration of our solar system. In general, the efficiency of low-thrust propulsion is one means of improving mission payload mass. At the same time, gravity-assist maneuvers can serve as mission enablers, as they have the capability to provide "free energy." A combination of both, gravity-assist and low-thrust propulsion, has the potential to generally improve mission performance, i.e. planning and optimization of gravity-assist sequences for low-thrust missions is a desirable asset. Currently no established methods exist to include the gravity-assist partners as optimization variable for low-thrust missions. The present paper explains how gravity-assists are planned and optimized, including the gravity-assist partners, for high-thrust missions and discusses the possibility to transfer the established method, based on the Tisserand Criterion, to low-thrust missions. It is shown how the Tisserand Criterion needs to be adapted using a correction term for the low-thrust situation. It is explained why this necessary correction term excludes an a priori evaluation of sequences and therefore their planning and an alternate approach is proposed. Preliminary results of this method, by application of a Differential Evolution optimization algorithm, are presented and discussed, showing that the method is valid but can be improved. Two constraints on the search space are briefly presented for that aim.

Cluster categorization of urban roads to optimize their noise monitoring.

PubMed

Zambon, G; Benocci, R; Brambilla, G

2016-01-01

Road traffic in urban areas is recognized to be associated with urban mobility and public health, and it is often the main source of noise pollution. Lately, noise maps have been considered a powerful tool to estimate the population exposure to environmental noise, but they need to be validated by measured noise data. The project Dynamic Acoustic Mapping (DYNAMAP), co-funded in the framework of the LIFE 2013 program, is aimed to develop a statistically based method to optimize the choice and the number of monitoring sites and to automate the noise mapping update using the data retrieved from a low-cost monitoring network. Indeed, the first objective should improve the spatial sampling based on the legislative road classification, as this classification is mainly based on the geometrical characteristics of the road, rather than its noise emission. The present paper describes the statistical approach of the methodology under development and the results of its preliminary application to a limited sample of roads in the city of Milan. The resulting categorization of roads, based on clustering the 24-h hourly L Aeqh, looks promising to optimize the spatial sampling of noise monitoring toward a description of the noise pollution due to complex urban road networks more efficient than that based on the legislative road classification.

A review on existing OSSEs and their implications on European marine observation requirements

NASA Astrophysics Data System (ADS)

She, Jun

2017-04-01

Marine observations are essential for understanding marine processes and improving the forecast quality, they are also expensive. It has always been an important issue to optimize sampling schemes of marine observational networks so that the value of marine observations can be maximized and the cost can be lowered. Ocean System Simulation Experiment (OSSE) is an efficient tool in assessing impacts of proposed future sampling schemes on reconstructing and forecasting the ocean and ecosystem conditions. In this study existing OSSE research results from EU projects (such as JERICO, OPEC, SANGOMA, E-AIMS and AtlantOS), institutional studies and review papers are collected and analyzed, according to regions (Arctic, Baltic, N. Atlantic, Mediterranean Sea and Black Sea) and instruments/variables. The preliminary results show that significant gaps for OSSEs in regions and instruments. Among the existing OSSEs, Argo (Bio-Argo and Deep See Argo), gliders and ferrybox are the most often investigated instruments. Although many of the OSSEs are dedicated for very specific monitoring strategies and not sufficiently comprehensive for making solid recommendations for optimizing the existing networks, the detailed findings for future marine observation requirements from the OSSEs will be summarized in the presentation. Recommendations for systematic OSSEs for optimizing European marine observation networks are also given.

An accurate homogenized tissue phantom for broad spectrum autofluorescence studies: a tool for optimizing quantum dot-based contrast agents

NASA Astrophysics Data System (ADS)

Roy, Mathieu; Wilson, Brian C.

2008-02-01

We are investigating the use of ZnS-capped CdSe quantum dot (QD) bioconjugates combined with fluorescence endoscopy for improved early cancer detection in the esophagus, colon and lung. A major challenge in using fluorescent contrast agents in vivo is to extract the relevant signal from the tissue autofluorescence (AF). The present studies are aimed at maximizing the QD signal to AF background ratio (SBR) to facilitate detection. These contrast optimization studies require optical phantoms that simulate tissue autofluorescence, absorption and scattering over the entire visible spectrum, while allowing us to control the optical thickness. We present an optical phantom made of fresh homogenized tissue diluted in water. The homogenized tissue is poured into a clear polymer tank designed to hold a QD-loaded silica capillary in its center. Because of the non-linear effects of absorption and scattering on measured autofluorescence, direct comparison between results obtained using tissue phantoms of different concentration is not possible. We introduce mathematical models that make it possible to perform measurements on diluted tissue homogenates and subsequently extrapolate the results to intact (non-diluted) tissue. Finally, we present preliminary QD contrast data showing that the 380-420 nm spectral window is optimal for surface QD imaging.

A multi-fidelity framework for physics based rotor blade simulation and optimization

NASA Astrophysics Data System (ADS)

Collins, Kyle Brian

New helicopter rotor designs are desired that offer increased efficiency, reduced vibration, and reduced noise. Rotor Designers in industry need methods that allow them to use the most accurate simulation tools available to search for these optimal designs. Computer based rotor analysis and optimization have been advanced by the development of industry standard codes known as "comprehensive" rotorcraft analysis tools. These tools typically use table look-up aerodynamics, simplified inflow models and perform aeroelastic analysis using Computational Structural Dynamics (CSD). Due to the simplified aerodynamics, most design studies are performed varying structural related design variables like sectional mass and stiffness. The optimization of shape related variables in forward flight using these tools is complicated and results are viewed with skepticism because rotor blade loads are not accurately predicted. The most accurate methods of rotor simulation utilize Computational Fluid Dynamics (CFD) but have historically been considered too computationally intensive to be used in computer based optimization, where numerous simulations are required. An approach is needed where high fidelity CFD rotor analysis can be utilized in a shape variable optimization problem with multiple objectives. Any approach should be capable of working in forward flight in addition to hover. An alternative is proposed and founded on the idea that efficient hybrid CFD methods of rotor analysis are ready to be used in preliminary design. In addition, the proposed approach recognizes the usefulness of lower fidelity physics based analysis and surrogate modeling. Together, they are used with high fidelity analysis in an intelligent process of surrogate model building of parameters in the high fidelity domain. Closing the loop between high and low fidelity analysis is a key aspect of the proposed approach. This is done by using information from higher fidelity analysis to improve predictions made with lower fidelity models. This thesis documents the development of automated low and high fidelity physics based rotor simulation frameworks. The low fidelity framework uses a comprehensive code with simplified aerodynamics. The high fidelity model uses a parallel processor capable CFD/CSD methodology. Both low and high fidelity frameworks include an aeroacoustic simulation for prediction of noise. A synergistic process is developed that uses both the low and high fidelity frameworks together to build approximate models of important high fidelity metrics as functions of certain design variables. To test the process, a 4-bladed hingeless rotor model is used as a baseline. The design variables investigated include tip geometry and spanwise twist distribution. Approximation models are built for metrics related to rotor efficiency and vibration using the results from 60+ high fidelity (CFD/CSD) experiments and 400+ low fidelity experiments. Optimization using the approximation models found the Pareto Frontier anchor points, or the design having maximum rotor efficiency and the design having minimum vibration. Various Pareto generation methods are used to find designs on the frontier between these two anchor designs. When tested in the high fidelity framework, the Pareto anchor designs are shown to be very good designs when compared with other designs from the high fidelity database. This provides evidence that the process proposed has merit. Ultimately, this process can be utilized by industry rotor designers with their existing tools to bring high fidelity analysis into the preliminary design stage of rotors. In conclusion, the methods developed and documented in this thesis have made several novel contributions. First, an automated high fidelity CFD based forward flight simulation framework has been built for use in preliminary design optimization. The framework was built around an integrated, parallel processor capable CFD/CSD/AA process. Second, a novel method of building approximate models of high fidelity parameters has been developed. The method uses a combination of low and high fidelity results and combines Design of Experiments, statistical effects analysis, and aspects of approximation model management. And third, the determination of rotor blade shape variables through optimization using CFD based analysis in forward flight has been performed. This was done using the high fidelity CFD/CSD/AA framework and method mentioned above. While the low and high fidelity predictions methods used in the work still have inaccuracies that can affect the absolute levels of the results, a framework has been successfully developed and demonstrated that allows for an efficient process to improve rotor blade designs in terms of a selected choice of objective function(s). Using engineering judgment, this methodology could be applied today to investigate opportunities to improve existing designs. With improvements in the low and high fidelity prediction components that will certainly occur, this framework could become a powerful tool for future rotorcraft design work. (Abstract shortened by UMI.)

Mass-based design and optimization of wave rotors for gas turbine engine enhancement

NASA Astrophysics Data System (ADS)

Chan, S.; Liu, H.

2017-03-01

An analytic method aiming at mass properties was developed for the preliminary design and optimization of wave rotors. In the present method, we introduce the mass balance principle into the design and thus can predict and optimize the mass qualities as well as the performance of wave rotors. A dedicated least-square method with artificial weighting coefficients was developed to solve the over-constrained system in the mass-based design. This method and the adoption of the coefficients were validated by numerical simulation. Moreover, the problem of fresh air exhaustion (FAE) was put forward and analyzed, and exhaust gas recirculation (EGR) was investigated. Parameter analyses and optimization elucidated which designs would not only achieve the best performance, but also operate with minimum EGR and no FAE.

Aerodynamic Shape Optimization of Supersonic Aircraft Configurations via an Adjoint Formulation on Parallel Computers

NASA Technical Reports Server (NTRS)

Reuther, James; Alonso, Juan Jose; Rimlinger, Mark J.; Jameson, Antony

1996-01-01

This work describes the application of a control theory-based aerodynamic shape optimization method to the problem of supersonic aircraft design. The design process is greatly accelerated through the use of both control theory and a parallel implementation on distributed memory computers. Control theory is employed to derive the adjoint differential equations whose solution allows for the evaluation of design gradient information at a fraction of the computational cost required by previous design methods. The resulting problem is then implemented on parallel distributed memory architectures using a domain decomposition approach, an optimized communication schedule, and the MPI (Message Passing Interface) Standard for portability and efficiency. The final result achieves very rapid aerodynamic design based on higher order computational fluid dynamics methods (CFD). In our earlier studies, the serial implementation of this design method was shown to be effective for the optimization of airfoils, wings, wing-bodies, and complex aircraft configurations using both the potential equation and the Euler equations. In our most recent paper, the Euler method was extended to treat complete aircraft configurations via a new multiblock implementation. Furthermore, during the same conference, we also presented preliminary results demonstrating that this basic methodology could be ported to distributed memory parallel computing architectures. In this paper, our concern will be to demonstrate that the combined power of these new technologies can be used routinely in an industrial design environment by applying it to the case study of the design of typical supersonic transport configurations. A particular difficulty of this test case is posed by the propulsion/airframe integration.

Electrically Driven Liquid Film Boiling Experiment

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2016-01-01

This presentation presents the science background and ground based results that form the basis of the Electrically Driven Liquid Film Boiling Experiment. This is an ISS experiment that is manifested for 2021. Objective: Characterize the effects of gravity on the interaction of electric and flow fields in the presence of phase change specifically pertaining to: a) The effects of microgravity on the electrically generated two-phase flow. b) The effects of microgravity on electrically driven liquid film boiling (includes extreme heat fluxes). Electro-wetting of the boiling section will repel the bubbles away from the heated surface in microgravity environment. Relevance/Impact: Provides phenomenological foundation for the development of electric field based two-phase thermal management systems leveraging EHD, permitting optimization of heat transfer surface area to volume ratios as well as achievement of high heat transfer coefficients thus resulting in system mass and volume savings. EHD replaces buoyancy or flow driven bubble removal from heated surface. Development Approach: Conduct preliminary experiments in low gravity and ground-based facilities to refine technique and obtain preliminary data for model development. ISS environment required to characterize electro-wetting effect on nucleate boiling and CHF in the absence of gravity. Will operate in the FIR - designed for autonomous operation.

Bent Laue X-ray Fluorescence Imaging of Manganese in Biological Tissues—Preliminary Results

NASA Astrophysics Data System (ADS)

Zhu, Ying; Bewer, Brian; Zhang, Honglin; Nichol, Helen; Thomlinson, Bill; Chapman, Dean

2010-06-01

Manganese (Mn) is not abundant in human brain tissue, but it is recognized as a neurotoxin. The symptoms of manganese intoxication are similar to Parkinson's disease (PD), but the link between environmental, occupational or dietary Mn exposure and PD in humans is not well established. X-ray Absorption Spectroscopy (XAS) and in particular X-ray fluorescence can provide precise information on the distribution, concentration and chemical form of metals. However the scattered radiation and fluorescence from the adjacent abundant element, iron (Fe), may interfere with and limit the ability to detect ultra-dilute Mn. A bent Laue analyzer based Mn fluorescence detection system has been designed and fabricated to improve elemental specificity in XAS imaging. This bent Laue analyzer of logarithmic spiral shape placed upstream of an energy discriminating detector should improve the energy resolution from hundreds of eV to several eV. The bent Laue detection system was validated by imaging Mn fluorescence from Mn foils, gelatin calibration samples and adult Drosophila at the Hard X-ray MicroAnalysis (HXMA) beamline at the Canadian Light Source (CLS). Optimization of the design parameters, fabrication procedures and preliminary experimental results are presented along with future plans.

Preliminary design of the cavity-end deformable mirror of the megajoule laser

NASA Astrophysics Data System (ADS)

Bozec, Xavier; Mercier-Ythier, Renaud; Carel, Jean-Louis; Coustal, Pierre; Michelin, Jean L.

1999-07-01

This paper describes a preliminary design to realize a 400 X 400 mm2 active deformable mirror in the framework of the LaserMegajoule French program. The proposed design is based on a force control strategy. Forces are generated by specific designed electromechanical actuators and transmitted to a Zerodur mirror through an annular soft pad. This pad is optimized to filter high frequency ripple generated by the spatial sampling of the efforts at the back of the mirror in order to decrease the needed number of actuators, and thus the cost of the deformable mirror, a specific optimization method has been developed and is applied to determine the best actuator pattern fitted on the wavefront aberrations to be corrected. Analysis, calculations, finite elements models, preliminary test and validations on breadboard models have shown that the proposed design in compliant with the functional and operation requirements. A design description and the main justifications, as the guidelines of mirror integration are given in this paper. Due to the simplicity of the concept and the use of validate and mastered technologies at SFIM Industries and REOSC, the design present a good reliability. Furthermore, a complete and very easy to work maintainability is favored by this deformable mirror definition. Each parts of the system is easily removable and replaceable on the laser line without carrying out a heavy procedure and complex tools.

Assessing Methods for Mapping 2D Field Concentrations of CO2 Over Large Spatial Areas for Monitoring Time Varying Fluctuations

NASA Astrophysics Data System (ADS)

Zaccheo, T. S.; Pernini, T.; Botos, C.; Dobler, J. T.; Blume, N.; Braun, M.; Levine, Z. H.; Pintar, A. L.

2014-12-01

This work presents a methodology for constructing 2D estimates of CO2 field concentrations from integrated open path measurements of CO2 concentrations. It provides a description of the methodology, an assessment based on simulated data and results from preliminary field trials. The Greenhouse gas Laser Imaging Tomography Experiment (GreenLITE) system, currently under development by Exelis and AER, consists of a set of laser-based transceivers and a number of retro-reflectors coupled with a cloud-based compute environment to enable real-time monitoring of integrated CO2 path concentrations, and provides 2D maps of estimated concentrations over an extended area of interest. The GreenLITE transceiver-reflector pairs provide laser absorption spectroscopy (LAS) measurements of differential absorption due to CO2 along intersecting chords within the field of interest. These differential absorption values for the intersecting chords of horizontal path are not only used to construct estimated values of integrated concentration, but also employed in an optimal estimation technique to derive 2D maps of underlying concentration fields. This optimal estimation technique combines these sparse data with in situ measurements of wind speed/direction and an analytic plume model to provide tomographic-like reconstruction of the field of interest. This work provides an assessment of this reconstruction method and preliminary results from the Fall 2014 testing at the Zero Emissions Research and Technology (ZERT) site in Bozeman, Montana. This work is funded in part under the GreenLITE program developed under a cooperative agreement between Exelis and the National Energy and Technology Laboratory (NETL) under the Department of Energy (DOE), contract # DE-FE0012574. Atmospheric and Environmental Research, Inc. is a major partner in this development.

Embedded algorithms within an FPGA-based system to process nonlinear time series data

NASA Astrophysics Data System (ADS)

Jones, Jonathan D.; Pei, Jin-Song; Tull, Monte P.

2008-03-01

This paper presents some preliminary results of an ongoing project. A pattern classification algorithm is being developed and embedded into a Field-Programmable Gate Array (FPGA) and microprocessor-based data processing core in this project. The goal is to enable and optimize the functionality of onboard data processing of nonlinear, nonstationary data for smart wireless sensing in structural health monitoring. Compared with traditional microprocessor-based systems, fast growing FPGA technology offers a more powerful, efficient, and flexible hardware platform including on-site (field-programmable) reconfiguration capability of hardware. An existing nonlinear identification algorithm is used as the baseline in this study. The implementation within a hardware-based system is presented in this paper, detailing the design requirements, validation, tradeoffs, optimization, and challenges in embedding this algorithm. An off-the-shelf high-level abstraction tool along with the Matlab/Simulink environment is utilized to program the FPGA, rather than coding the hardware description language (HDL) manually. The implementation is validated by comparing the simulation results with those from Matlab. In particular, the Hilbert Transform is embedded into the FPGA hardware and applied to the baseline algorithm as the centerpiece in processing nonlinear time histories and extracting instantaneous features of nonstationary dynamic data. The selection of proper numerical methods for the hardware execution of the selected identification algorithm and consideration of the fixed-point representation are elaborated. Other challenges include the issues of the timing in the hardware execution cycle of the design, resource consumption, approximation accuracy, and user flexibility of input data types limited by the simplicity of this preliminary design. Future work includes making an FPGA and microprocessor operate together to embed a further developed algorithm that yields better computational and power efficiency.

Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments.

PubMed

Cahyadi, Christine; Heng, Paul Wan Sia; Chan, Lai Wah

2011-03-01

The aim of this study was to identify and optimize the critical process parameters of the newly developed Supercell quasi-continuous coater for optimal tablet coat quality. Design of experiments, aided by multivariate analysis techniques, was used to quantify the effects of various coating process conditions and their interactions on the quality of film-coated tablets. The process parameters varied included batch size, inlet temperature, atomizing pressure, plenum pressure, spray rate and coating level. An initial screening stage was carried out using a 2(6-1(IV)) fractional factorial design. Following these preliminary experiments, optimization study was carried out using the Box-Behnken design. Main response variables measured included drug-loading efficiency, coat thickness variation, and the extent of tablet damage. Apparent optimum conditions were determined by using response surface plots. The process parameters exerted various effects on the different response variables. Hence, trade-offs between individual optima were necessary to obtain the best compromised set of conditions. The adequacy of the optimized process conditions in meeting the combined goals for all responses was indicated by the composite desirability value. By using response surface methodology and optimization, coating conditions which produced coated tablets of high drug-loading efficiency, low incidences of tablet damage and low coat thickness variation were defined. Optimal conditions were found to vary over a large spectrum when different responses were considered. Changes in processing parameters across the design space did not result in drastic changes to coat quality, thereby demonstrating robustness in the Supercell coating process. © 2010 American Association of Pharmaceutical Scientists

Optimization of a Turboprop UAV for Maximum Loiter and Specific Power Using Genetic Algorithm

NASA Astrophysics Data System (ADS)

Dinc, Ali

2016-09-01

In this study, a genuine code was developed for optimization of selected parameters of a turboprop engine for an unmanned aerial vehicle (UAV) by employing elitist genetic algorithm. First, preliminary sizing of a UAV and its turboprop engine was done, by the code in a given mission profile. Secondly, single and multi-objective optimization were done for selected engine parameters to maximize loiter duration of UAV or specific power of engine or both. In single objective optimization, as first case, UAV loiter time was improved with an increase of 17.5% from baseline in given boundaries or constraints of compressor pressure ratio and burner exit temperature. In second case, specific power was enhanced by 12.3% from baseline. In multi-objective optimization case, where previous two objectives are considered together, loiter time and specific power were increased by 14.2% and 9.7% from baseline respectively, for the same constraints.

Research on design method of the full form ship with minimum thrust deduction factor

NASA Astrophysics Data System (ADS)

Zhang, Bao-ji; Miao, Ai-qin; Zhang, Zhu-xin

2015-04-01

In the preliminary design stage of the full form ships, in order to obtain a hull form with low resistance and maximum propulsion efficiency, an optimization design program for a full form ship with the minimum thrust deduction factor has been developed, which combined the potential flow theory and boundary layer theory with the optimization technique. In the optimization process, the Sequential Unconstrained Minimization Technique (SUMT) interior point method of Nonlinear Programming (NLP) was proposed with the minimum thrust deduction factor as the objective function. An appropriate displacement is a basic constraint condition, and the boundary layer separation is an additional one. The parameters of the hull form modification function are used as design variables. At last, the numerical optimization example for lines of after-body of 50000 DWT product oil tanker was provided, which indicated that the propulsion efficiency was improved distinctly by this optimal design method.

Application of advanced technologies to small, short-haul aircraft

NASA Technical Reports Server (NTRS)

Andrews, D. G.; Brubaker, P. W.; Bryant, S. L.; Clay, C. W.; Giridharadas, B.; Hamamoto, M.; Kelly, T. J.; Proctor, D. K.; Myron, C. E.; Sullivan, R. L.

1978-01-01

The results of a preliminary design study which investigates the use of selected advanced technologies to achieve low cost design for small (50-passenger), short haul (50 to 1000 mile) transports are reported. The largest single item in the cost of manufacturing an airplane of this type is labor. A careful examination of advanced technology to airframe structure was performed since one of the most labor-intensive parts of the airplane is structures. Also, preliminary investigation of advanced aerodynamics flight controls, ride control and gust load alleviation systems, aircraft systems and turbo-prop propulsion systems was performed. The most beneficial advanced technology examined was bonded aluminum primary structure. The use of this structure in large wing panels and body sections resulted in a greatly reduced number of parts and fasteners and therefore, labor hours. The resultant cost of assembled airplane structure was reduced by 40% and the total airplane manufacturing cost by 16% - a major cost reduction. With further development, test verification and optimization appreciable weight saving is also achievable. Other advanced technology items which showed significant gains are as follows: (1) advanced turboprop-reduced block fuel by 15.30% depending on range; (2) configuration revisions (vee-tail)-empennage cost reduction of 25%; (3) leading-edge flap addition-weight reduction of 2500 pounds.

Preliminary test results of electrical charged particle generator for application to fog dispersal

NASA Technical Reports Server (NTRS)

Frost, W.

1982-01-01

A charged particle generator for use in fog dispersal applications was built and preliminary tests were carried out. The parameter used as a measure of performance was the current measured with a needle probe positioned in the charged jet connected to ground through an ammeter. The needle was movable and allowed the current profile throughout the jet to be determined. The measured current is referred to as the current output. The major independent parameters were liquid water injection rate, plenum pressure, and corona voltage. Optimum current output was achieved at the approximate pressure of 30 psig, corona voltage of 5600 volts, and liquid water injection rate of 6 cc/min. The results of the test with the prototype charged particle generator clearly demonstrate that a current on the order of 20 microamperes can be routinely achieved with the system. This measurement of current does not necessarily represent the total issuing from the nozzle current which is expected to be larger. From these results, confidence was established that a charged particle generator which will operate continuously and consistently can be designed, constructed, and operated. Further work is required, however, to better understand the physical mechanisms involved and to optimize the system for fog dispersal application.

77 FR 6061 - Citric Acid and Certain Citrate Salts From Canada: Preliminary Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-07

... Citrate Salts From Canada: Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import... below normal value (NV). If the preliminary results are adopted in the final results of the... all appropriate entries. Interested parties are invited to comment on the preliminary results. FOR...

78 FR 28192 - Polyethylene Retail Carrier Bags From Thailand: Preliminary Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... Bags From Thailand: Preliminary Results of Antidumping Duty Administrative Review; 2011-2012 AGENCY... Import Administration, ``Decision Memorandum for Preliminary Results of the 2011/12 Antidumping Duty... (August 12, 2010) (Section 129 Determination). Preliminary Results of Review As a result of our review, we...

Development of a semidefined growth medium for Pedobacter cryoconitis BG5 using statistical experimental design.

PubMed

Ong, Magdalena; Ongkudon, Clarence M; Wong, Clemente Michael Vui Ling

2016-10-02

Pedobacter cryoconitis BG5 are psychrophiles isolated from the cold environment and capable of proliferating and growing well at low temperature regime. Their cellular products have found a broad spectrum of applications, including in food, medicine, and bioremediation. Therefore, it is imperative to develop a high-cell density cultivation strategy coupled with optimized growth medium for P. cryoconitis BG5. To date, there has been no published report on the design and optimization of growth medium for P. cryoconitis, hence the objective of this research project. A preliminary screening of four commercially available media, namely tryptic soy broth, R2A, Luria Bertani broth, and nutrient broth, was conducted to formulate the basal medium. Based on the preliminary screening, tryptone, glucose, NaCl, and K2HPO4 along with three additional nutrients (yeast extract, MgSO4, and NH4Cl) were identified to form the basal medium which was further analyzed by Plackett-Burman experimental design. Central composite experimental design using response surface methodology was adopted to optimize tryptone, yeast extract, and NH4Cl concentrations in the formulated growth medium. Statistical data analysis showed a high regression factor of 0.84 with a predicted optimum optical (600 nm) cell density of 7.5 using 23.7 g/L of tryptone, 8.8 g/L of yeast extract, and 0.7 g/L of NH4Cl. The optimized medium for P. cryoconitis BG5 was tested, and the observed optical density was 7.8. The cost-effectiveness of the optimized medium was determined as 6.25 unit prices per gram of cell produced in a 250-ml Erlenmeyer flask.

Methodology for sensitivity analysis, approximate analysis, and design optimization in CFD for multidisciplinary applications. [computational fluid dynamics

NASA Technical Reports Server (NTRS)

Taylor, Arthur C., III; Hou, Gene W.

1992-01-01

Fundamental equations of aerodynamic sensitivity analysis and approximate analysis for the two dimensional thin layer Navier-Stokes equations are reviewed, and special boundary condition considerations necessary to apply these equations to isolated lifting airfoils on 'C' and 'O' meshes are discussed in detail. An efficient strategy which is based on the finite element method and an elastic membrane representation of the computational domain is successfully tested, which circumvents the costly 'brute force' method of obtaining grid sensitivity derivatives, and is also useful in mesh regeneration. The issue of turbulence modeling is addressed in a preliminary study. Aerodynamic shape sensitivity derivatives are efficiently calculated, and their accuracy is validated on two viscous test problems, including: (1) internal flow through a double throat nozzle, and (2) external flow over a NACA 4-digit airfoil. An automated aerodynamic design optimization strategy is outlined which includes the use of a design optimization program, an aerodynamic flow analysis code, an aerodynamic sensitivity and approximate analysis code, and a mesh regeneration and grid sensitivity analysis code. Application of the optimization methodology to the two test problems in each case resulted in a new design having a significantly improved performance in the aerodynamic response of interest.

Optimization of the fiber laser parameters for local high-temperature impact on metal

NASA Astrophysics Data System (ADS)

Yatsko, Dmitrii S.; Polonik, Marina V.; Dudko, Olga V.

2016-11-01

This paper presents the local laser heating process of surface layer of the metal sample. The aim is to create the molten pool with the required depth by laser thermal treatment. During the heating the metal temperature at any point of the molten zone should not reach the boiling point of the main material. The laser power, exposure time and the spot size of a laser beam are selected as the variable parameters. The mathematical model for heat transfer in a semi-infinite body, applicable to finite slab, is used for preliminary theoretical estimation of acceptable parameters values of the laser thermal treatment. The optimization problem is solved by using an algorithm based on the scanning method of the search space (the zero-order method of conditional optimization). The calculated values of the parameters (the optimal set of "laser radiation power - exposure time - spot radius") are used to conduct a series of natural experiments to obtain a molten pool with the required depth. A two-stage experiment consists of: a local laser treatment of metal plate (steel) and then the examination of the microsection of the laser irradiated region. According to the experimental results, we can judge the adequacy of the ongoing calculations within the selected models.

The optimization of phthalate analysis from plastic matrices by using GC/MS related techniques

NASA Astrophysics Data System (ADS)

Pusfitasari, Eka Dian; Hendarsyah, Hendris; Athaillah, Zatil Afrah

2017-11-01

Indication of malicious acts conducted by food vendors has been reported in many places in Indonesia and has been worrying the population. One of the issues is the indication that frying oil used by the vendors has been added with food packaging plastic to impart more crispy texture of the fried foods. One of the challenges for the monitoring process is to find suitable analytical method to identify this type of food adulteration. Because some food packaging, particularly from polyethylene group, contains plasticizer diethylhexylphthalate (DEHP), we intended to investigate the adulteration by detecting the phthalate compound. In this preliminary study, we focused on the optimization of GC equipment as well as the optimization of plastic extraction process with various types of solvents (hexane, dichloromethane, and acetonitrile) and extraction time (24, 48, and 72 hours). For 72-hour duration, treatment with solvent refreshment was also conducted to minimize solvent saturation effect. Our findings suggested that LOD and LOQ of the GC/MS instrument used for the DEHP analysis were 19.6 ng and 65.5 ng, respectively. In addition, it could be concluded that the process of plastic extraction through sonication for five minutes with n-hexane as a solvent resulted in the optimal value.

Tuning Parameters in Heuristics by Using Design of Experiments Methods

NASA Technical Reports Server (NTRS)

Arin, Arif; Rabadi, Ghaith; Unal, Resit

2010-01-01

With the growing complexity of today's large scale problems, it has become more difficult to find optimal solutions by using exact mathematical methods. The need to find near-optimal solutions in an acceptable time frame requires heuristic approaches. In many cases, however, most heuristics have several parameters that need to be "tuned" before they can reach good results. The problem then turns into "finding best parameter setting" for the heuristics to solve the problems efficiently and timely. One-Factor-At-a-Time (OFAT) approach for parameter tuning neglects the interactions between parameters. Design of Experiments (DOE) tools can be instead employed to tune the parameters more effectively. In this paper, we seek the best parameter setting for a Genetic Algorithm (GA) to solve the single machine total weighted tardiness problem in which n jobs must be scheduled on a single machine without preemption, and the objective is to minimize the total weighted tardiness. Benchmark instances for the problem are available in the literature. To fine tune the GA parameters in the most efficient way, we compare multiple DOE models including 2-level (2k ) full factorial design, orthogonal array design, central composite design, D-optimal design and signal-to-noise (SIN) ratios. In each DOE method, a mathematical model is created using regression analysis, and solved to obtain the best parameter setting. After verification runs using the tuned parameter setting, the preliminary results for optimal solutions of multiple instances were found efficiently.

Studying Treatment Intensity: Lessons from Two Preliminary Studies

ERIC Educational Resources Information Center

Neil, Nicole; Jones, Emily A.

2015-01-01

Determining how best to meet the needs of learners with Down syndrome requires an approach to intervention delivered at some level of intensity. How treatment intensity affects learner acquisition, maintenance, and generalization of skills can help optimize the efficiency and cost-effectiveness of interventions. There is a growing body of research…

A Preliminary Examination of Covitality as Integrated Well-Being in College Students

ERIC Educational Resources Information Center

Jones, Camille N.; You, Sukkyung; Furlong, Michael J.

2013-01-01

The emergence of positive psychology has generated increased interest about the correlates of positive psychological functioning. Researchers have identified and studied various positive psychological constructs (e.g., hope, optimism, self-efficacy, gratitude, and life satisfaction) and found them to covary and to be positively associated with…

Prototype through-pellicle coherent imaging using a 30nm tabletop EUV source

NASA Astrophysics Data System (ADS)

Bevis, Charles S.; Karl, Robert M.; Wang, Bin; Esashi, Yuka; Tanksalvala, Michael; Porter, Christina L.; Johnsen, Peter; Adams, Daniel E.; Murnane, Margaret M.; Kapteyn, Henry C.

2018-03-01

We present preliminary through-pellicle imaging using a 30nm tabletop extreme ultraviolet (EUV) coherent diffractive imaging microscope. We show that even in a non-optimized setup, this technique enables through-pellicle imaging of a sample with no detectable impact on image fidelity or resolution.

Extending Flow Further: Narrative of a Filipino Musician

ERIC Educational Resources Information Center

Garces-Bacsal, Rhoda Myra

2016-01-01

This paper is a preliminary attempt to describe how flow was experienced by an eminent singer-songwriter from the Philippines. Csikszentmihalyi (1990, 1996) has written extensively about the elements of the flow state among creative people and its contributions to positive psychology and optimal level of functioning. Through multiple in-depth…

Intense Terahertz Fields for Fast Energy Release

DTIC Science & Technology

2016-11-01

could allow us to monitor shock propagation in the sample and observe any effects of THz irradiation . In order to optimize the system, we moved a...the response and access for the THz light needed to simultaneously irradiate the sample. Preliminary measurements of sample responses to each of the

Identification and hit-to-lead optimization of a novel class of CB1 antagonists.

PubMed

Letourneau, Jeffrey J; Jokiel, Patrick; Olson, John; Riviello, Christopher M; Ho, Koc-Kan; McAleer, Lihong; Yang, Jingchun; Swanson, Robert N; Baker, James; Cowley, Phillip; Edwards, Darren; Ward, Nick; Ohlmeyer, Michael H J; Webb, Maria L

2010-09-15

The discovery, synthesis and preliminary structure-activity relationships (SARs) of a novel class of CB1 antagonists is described. Initial optimization of benzimidazole-based screening hit 4 led to the identification of 'inverted' indole-based lead compound 18c with improved properties versus compound 4 including reduced AlogP, improved microsomal stability and improved aqueous solubility. Compound 18c demonstrates in vivo CB1 antagonist efficacy (CB1 agonist induced hypothermia model) and is orally bioavailable in rat. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Hormesis and the salk polio vaccine.

PubMed

Calabrese, Edward J

2012-01-01

The production of the Salk vaccine polio virus by monkey kidney cells was generated using the synthetic tissue culture medium, Mixture 199. In this paper's retrospective assessment of this process, it was discovered that Mixture 199 was modified by the addition of ethanol to optimize animal cell survival based on experimentation that revealed a hormetic-like biphasic response relationship. This hormesis-based optimization procedure was then applied to all uses of Mixture 199 and modifications of it, including its application to the Salk polio vaccine during preliminary testing and in its subsequent major societal treatment programs.

76 FR 44305 - Honey From Argentina: Extension of Time Limit for Preliminary Results of Antidumping Duty New...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

...: Extension of Time Limit for Preliminary Results of Antidumping Duty New Shipper Review AGENCY: Import... results of this review is July 24, 2011. Extension of Time Limits for Preliminary Results of Review... time to complete the preliminary results. Specifically, the Department requires additional time to...

Detection of biomolecules in complex media using surface plasmon resonance sensors

NASA Astrophysics Data System (ADS)

Malone, Michael R.; Masson, Jean-Francois; Barhnart, Margaret; Beaudoin, Stephen; Booksh, Karl S.

2005-11-01

Detection of multiple biologically relevant molecules was accomplished at sub-ng/mL levels in highly fouling media using fiber- optic based surface plasmon resonance sensors. Myocardial infarction markers, myoglobin and cTnI, were quantified in full serum with limits of detection below 1 ng/mL. Biologically relevant levels are between 15-30 ng/mL and 1-5 ng/mL for myoglobin and cTnI respectively. Cytokines involved in chronic wound healing, Interleukin 1, Interleukin 6, and tumor necrosis factor α, were detected at around 1 ng/mL in cell culture media. Preliminary results in monitoring these cytokines in cell cultures expressing the cytokines were obtained. The protein diagnostic of spinal muscular atrophy, survival motor neuron protein, was quantified from cell lysate. To obtain such results in complex media, the sensor's stability to non-specific protein adsorption had to be optimized. A layer of the N-hydroxysuccinimide ester of 16-mercaptohexadecanoic acid is attached to the sensor. This layer optimizes the antibody attachment to the sensor while minimizing the non-specific signal from serum proteins.

Local search for optimal global map generation using mid-decadal landsat images

USGS Publications Warehouse

Khatib, L.; Gasch, J.; Morris, Robert; Covington, S.

2007-01-01

NASA and the US Geological Survey (USGS) are seeking to generate a map of the entire globe using Landsat 5 Thematic Mapper (TM) and Landsat 7 Enhanced Thematic Mapper Plus (ETM+) sensor data from the "mid-decadal" period of 2004 through 2006. The global map is comprised of thousands of scene locations and, for each location, tens of different images of varying quality to chose from. Furthermore, it is desirable for images of adjacent scenes be close together in time of acquisition, to avoid obvious discontinuities due to seasonal changes. These characteristics make it desirable to formulate an automated solution to the problem of generating the complete map. This paper formulates a Global Map Generator problem as a Constraint Optimization Problem (GMG-COP) and describes an approach to solving it using local search. Preliminary results of running the algorithm on image data sets are summarized. The results suggest a significant improvement in map quality using constraint-based solutions. Copyright ?? 2007, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.

Application-Oriented Chemical Optimization of a Metakaolin Based Geopolymer

PubMed Central

Ferone, Claudio; Colangelo, Francesco; Roviello, Giuseppina; Asprone, Domenico; Menna, Costantino; Balsamo, Alberto; Prota, Andrea; Cioffi, Raffaele; Manfredi, Gaetano

2013-01-01

In this study the development of a metakaolin based geopolymeric mortar to be used as bonding matrix for external strengthening of reinforced concrete beams is reported. Four geopolymer formulations have been obtained by varying the composition of the activating solution in terms of SiO2/Na2O ratio. The obtained samples have been characterized from a structural, microstructural and mechanical point of view. The differences in structure and microstructure have been correlated to the mechanical properties. A major issue of drying shrinkage has been encountered in the high Si/Al ratio samples. In the light of the characterization results, the optimal geopolymer composition was then applied to fasten steel fibers to reinforced concrete beams. The mechanical behavior of the strengthened reinforced beams was evaluated by four-points bending tests, which were performed also on reinforced concrete beams as they are for comparison. The preliminary results of the bending tests point out an excellent behavior of the geopolymeric mixture tested, with the failure load of the reinforced beams roughly twice that of the control beam. PMID:28809251

Preliminary Results of Solid Gas Generator Micropropulsion

NASA Technical Reports Server (NTRS)

deGroot, Wilhelmus A.; Reed, Brian D.; Brenizer, Marshall

1999-01-01

A decomposing solid thruster concept, which creates a more benign thermal and chemical environment than solid propellant combustion, while maintaining, performance similar to solid combustion, is described. A Micro-Electro-Mechanical (MEMS) thruster concept with diode laser and fiber-optic initiation is proposed, and thruster components fabricated with MEMS technology are presented. A high nitrogen content solid gas generator compound is evaluated and tested in a conventional axisymmetric thrust chamber with nozzle throat area ratio of 100. Results show incomplete decomposition of this compound in both low pressure (1 kPa) and high pressure (1 MPa) environments, with decomposition of up to 80% of the original mass. Chamber pressures of 1.1 MPa were obtained, with maximum calculated thrust of approximately 2.7 N. Resistively heated wires and resistively heated walls were used to initiate decomposition. Initiation tests using available lasers were unsuccessful, but infrared spectra of the compound show that the laser initiation tests used inappropriate wavelengths for optimal propellant absorption. Optimal wavelengths for laser ignition were identified. Data presented are from tests currently in progress. Alternative solid gas generator compounds are being evaluated for future tests.

Development of a NRSE Spectrometer with the Help of McStas - Application to the Design of Present and Future Instruments

NASA Astrophysics Data System (ADS)

Kredler, L.; Häußler, W.; Martin, N.; Böni, P.

The flux is still a major limiting factor in neutron research. For instruments being supplied by cold neutrons using neutron guides, both at present steady-state and at new spallation neutron sources, it is therefore important to optimize the instrumental setup and the neutron guidance. Optimization of neutron guide geometry and of the instrument itself can be performed by numerical ray-tracing simulations using existing open-access codes. In this paper, we discuss how such Monte Carlo simulations have been employed in order to plan improvements of the Neutron Resonant Spin Echo spectrometer RESEDA (FRM II, Germany) as well as the neutron guides before and within the instrument. The essential components have been represented with the help of the McStas ray-tracing package. The expected intensity has been tested by means of several virtual detectors, implemented in the simulation code. Comparison between simulations and preliminary measurements results shows good agreement and demonstrates the reliability of the numerical approach. These results will be taken into account in the planning of new components installed in the guide system.

Hybrid feature selection for supporting lightweight intrusion detection systems

NASA Astrophysics Data System (ADS)

Song, Jianglong; Zhao, Wentao; Liu, Qiang; Wang, Xin

2017-08-01

Redundant and irrelevant features not only cause high resource consumption but also degrade the performance of Intrusion Detection Systems (IDS), especially when coping with big data. These features slow down the process of training and testing in network traffic classification. Therefore, a hybrid feature selection approach in combination with wrapper and filter selection is designed in this paper to build a lightweight intrusion detection system. Two main phases are involved in this method. The first phase conducts a preliminary search for an optimal subset of features, in which the chi-square feature selection is utilized. The selected set of features from the previous phase is further refined in the second phase in a wrapper manner, in which the Random Forest(RF) is used to guide the selection process and retain an optimized set of features. After that, we build an RF-based detection model and make a fair comparison with other approaches. The experimental results on NSL-KDD datasets show that our approach results are in higher detection accuracy as well as faster training and testing processes.

78 FR 34648 - Citric Acid and Certain Citrate Salts: Preliminary Results of Countervailing Duty Administrative...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... Citrate Salts: Preliminary Results of Countervailing Duty Administrative Review; 2011 AGENCY: Import... December 31, 2011. These preliminary results cover RZBC Group Shareholding Co., Ltd., RZBC Co., Ltd., RZBC... Memorandum for the Preliminary Results of the Countervailing Duty Administrative Review: Citric Acid and...

Critical components of reflective supervision: responses from expert supervisors in the field.

PubMed

Tomlin, Angela M; Weatherston, Deborah J; Pavkov, Thomas

2014-01-01

This article offers a brief review of the history of supervision, defines reflective supervision, and reports the results of a Delphi study designed to identify critical components of reflective supervision. Academicians and master clinicians skilled in providing reflective supervision participated in a three-phase survey to elicit beliefs about best practice when engaging in reflective supervision. The process yielded consensus descriptions of optimal characteristics and behaviors of supervisors and supervisees when entering into supervisory relationships that encourage reflective practice. These results, although preliminary, suggest that it is possible to identify elements that are integral to effective reflective supervision. These initial findings may be used for future study of the reflective supervisory process. © 2013 Michigan Association for Infant Mental Health.

Impact of geostationary satellite water vapor channel data on weather analysis and forecasting

NASA Technical Reports Server (NTRS)

Velden, Christopher S.

1995-01-01

Preliminary results from NWP impact studies are indicating that upper-tropospheric wind information provided by tracking motions in sequences of geostationary satellite water vapor imagery can positively influence forecasts on regional scales, and possibly on global scales as well. The data are complimentary to cloud-tracked winds by providing data in cloud-free regions, as well as comparable in quality. First results from GOES-8 winds are encouraging, and further efforts and model impacts will be directed towards optimizing these data in numerical weather prediction (NWP). Assuming successful launches of GOES-J and GMS-5 satellites in 1995, high quality and resolution water vapor imagers will be available to provide nearly complete global upper-tropospheric wind coverage.

Limited-memory fast gradient descent method for graph regularized nonnegative matrix factorization.

PubMed

Guan, Naiyang; Wei, Lei; Luo, Zhigang; Tao, Dacheng

2013-01-01

Graph regularized nonnegative matrix factorization (GNMF) decomposes a nonnegative data matrix X[Symbol:see text]R(m x n) to the product of two lower-rank nonnegative factor matrices, i.e.,W[Symbol:see text]R(m x r) and H[Symbol:see text]R(r x n) (r < min {m,n}) and aims to preserve the local geometric structure of the dataset by minimizing squared Euclidean distance or Kullback-Leibler (KL) divergence between X and WH. The multiplicative update rule (MUR) is usually applied to optimize GNMF, but it suffers from the drawback of slow-convergence because it intrinsically advances one step along the rescaled negative gradient direction with a non-optimal step size. Recently, a multiple step-sizes fast gradient descent (MFGD) method has been proposed for optimizing NMF which accelerates MUR by searching the optimal step-size along the rescaled negative gradient direction with Newton's method. However, the computational cost of MFGD is high because 1) the high-dimensional Hessian matrix is dense and costs too much memory; and 2) the Hessian inverse operator and its multiplication with gradient cost too much time. To overcome these deficiencies of MFGD, we propose an efficient limited-memory FGD (L-FGD) method for optimizing GNMF. In particular, we apply the limited-memory BFGS (L-BFGS) method to directly approximate the multiplication of the inverse Hessian and the gradient for searching the optimal step size in MFGD. The preliminary results on real-world datasets show that L-FGD is more efficient than both MFGD and MUR. To evaluate the effectiveness of L-FGD, we validate its clustering performance for optimizing KL-divergence based GNMF on two popular face image datasets including ORL and PIE and two text corpora including Reuters and TDT2. The experimental results confirm the effectiveness of L-FGD by comparing it with the representative GNMF solvers.

Fiber optic thermo-hygrometers for soil moisture and temperature measurements: the SFORI project

NASA Astrophysics Data System (ADS)

Leone, M.; Consales, M.; Laudati, A.; Mennella, F.; Cutolo, A.; Cusano, A.

2015-09-01

This work deals with the development of fiber optic sensors for the measurement of soil moisture and temperature over large areas. It has been carried out within the Regional Project "Sensoristica in Fibra Ottica per il Risparmio Idrico - SFORI". The sensor system is based on the fiber Bragg gratings (FBGs) technology and is aimed at optimizing the irrigation practice in order to guarantee a sustainable water resources management. Two sensors networks, each one based on FBG thermo-hygrometers, have been realized and installed in two experimental sites. Preliminary results envisages good perspectives for a massive usage of the proposed technology.

Detector for positronium temperature measurements by two-photon angular correlation

NASA Astrophysics Data System (ADS)

Cecchini, G. G.; Jones, A. C. L.; Fuentes-Garcia, M.; Adams, D. J.; Austin, M.; Membreno, E.; Mills, A. P.

2018-05-01

We report on the design and characterization of a modular γ-ray detector assembly developed for accurate and efficient detection of coincident 511 keV back-to-back γ-rays following electron-positron annihilation. Each modular detector consists of 16 narrow lutetium yttrium oxyorthosilicate scintillators coupled to a multi-anode Hamamatsu H12700B photomultiplier tube. We discuss the operation and optimization of 511 keV γ-ray detection resulting from testing various scintillators and detector arrangements concluding with an estimate of the coincident 511 keV detection efficiency for the intended experiment and a preliminary test representing one-quarter of the completed array.

Synthesis and Evaluation of Novel Benzofuran Derivatives as Selective SIRT2 Inhibitors.

PubMed

Zhou, Yumei; Cui, Huaqing; Yu, Xiaoming; Peng, Tao; Wang, Gang; Wen, Xiaoxue; Sun, Yunbo; Liu, Shuchen; Zhang, Shouguo; Hu, Liming; Wang, Lin

2017-08-14

A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1-3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC 50 (half maximal inhibitory concentration) values at the micromolar level. The preliminary structure-activity relationships were analyzed and the binding features of compound 7e (IC 50 3.81 µM) was predicted using the CDOCKER program. The results of this research could provide informative guidance for further optimizing benzofuran derivatives as potent SIRT2 inhibitors.

Solar pond power plant feasibility study for Davis, California

NASA Technical Reports Server (NTRS)

Wu, Y. C.; Singer, M. J.; Marsh, H. E.; Harris, J.; Walton, A. L.

1982-01-01

The feasibility of constructing a solar pond power plant at Davis, California was studied. Site visits, weather data compilation, soil and water analyses, conceptual system design and analyses, a material and equipment market survey, conceptual site layout, and a preliminary cost estimate were studied. It was concluded that a solar pond power plant is technically feasible, but economically unattractive. The relatively small scale of the proposed plant and the high cost of importing salt resulted in a disproportionately high capital investment with respect to the annual energy production capacity of the plant. Cycle optimization and increased plant size would increase the economical attractiveness of the proposed concept.

Preliminary structural design of a lunar transfer vehicle aerobrake. M.S. Thesis

NASA Technical Reports Server (NTRS)

Bush, Lance B.

1992-01-01

An aerobrake concept for a Lunar transfer vehicle was weight optimized through the use of the Taguchi design method, structural finite element analyses and structural sizing routines. Six design parameters were chosen to represent the aerobrake structural configuration. The design parameters included honeycomb core thickness, diameter to depth ratio, shape, material, number of concentric ring frames, and number of radial frames. Each parameter was assigned three levels. The minimum weight aerobrake configuration resulting from the study was approx. half the weight of the average of all twenty seven experimental configurations. The parameters having the most significant impact on the aerobrake structural weight were identified.

Towards active capsular endoscopy: preliminary results on a legged platform.

PubMed

Menciassi, Arianna; Stefanini, Cesare; Orlandi, Giovanni; Quirini, Marco; Dario, Paolo

2006-01-01

This paper illustrates the problem of active locomotion in the gastrointestinal tract for endoscopic capsules. Authors analyze the problem of locomotion in unstructured, flexible and tubular environments and explain the reasons leading to the selection of a legged system. They present a theoretical simulation of legged capsule locomotion, which is used to define the optimal parameters for capsule design and gait selection. Finally, a legged capsule--about 3 cm3 in volume--is presented; it consists of 4 back legs whose actuation is achieved thanks to a miniaturized DC brushless motor. In vitro tests demonstrate good performance in terms of achievable speed (92 mm/min).

Design criteria and candidate electrical power systems for a reusable Space Shuttle booster.

NASA Technical Reports Server (NTRS)

Merrifield, D. V.

1972-01-01

This paper presents the results of a preliminary study to establish electrical power requirements, investigate candidate power sources, and select a representative power generation concept for the NASA Space Shuttle booster stage. Design guidelines and system performance requirements are established. Candidate power sources and combinations thereof are defined and weight estimates made. The selected power source concept utilizes secondary silver-zinc batteries, engine-driven alternators with constant speed drive, and an airbreathing gas turbine. The need for cost optimization, within safety, reliability, and performance constraints, is emphasized as being the most important criteria in design of the final system.

Wellhead power production with a rotary separator turbine (RP 1196)

NASA Astrophysics Data System (ADS)

Cerini, D. J.; Record, J.

1982-12-01

A rotary-separator turbine was built with full flow capacity for a 500 F downhole temperature with a 850,000 lbm/hr production rate. The test system and results obtained in field tests are described. The preliminary design of a 10-megawatt wellhead power plant for the Roosevelt type resource is described. This system shows a specific power of .0013 kW hr per lbm, which is 20 percent greater than an optimized wellhead single stage flash plant. This is 26 percent greater than a central plant of 20 to 50 MW capacity when consideration is given to steam-gathering system pressure drop between the wells and central plant.

Experimental model of the device for detection of nuclear cycle materials by photoneutron technology

NASA Astrophysics Data System (ADS)

Bakalyarov, A. M.; Karetnikov, M. D.; Kozlov, K. N.; Lebedev, V. I.; Meleshko, E. A.; Obinyakov, B. A.; Ostashev, I. E.; Tupikin, N. A.; Yakovlev, G. V.

2007-08-01

The inherent complexity of sea container control makes them potentially dangerous for smuggling nuclear materials. The experts believe that only active technologies based on recording the products of induced radiation from sensitive materials might solve the problem. The paper reports on the experimental model of the device on the basis of the electron LINAC U-28 for detection of nuclear materials by photonuclear technology. The preliminary numerical optimization of output units (converter, filter, collimator) for shaping the bremsstrahlung was carried out. The setup of experimental device and initial results of recording the prompt and delayed fission products are discussed.

Preliminary Benefits Assessment of Traffic Aware Strategic Aircrew Requests (TASAR)

NASA Technical Reports Server (NTRS)

Henderson, Jeff; Idris, Husni; Wing, David J.

2012-01-01

While en route, aircrews submit trajectory change requests to air traffic control (ATC) to better meet their objectives including reduced delays, reduced fuel burn, and passenger comfort. Aircrew requests are currently made with limited to no information on surrounding traffic. Consequently, these requests are uninformed about a key ATC objective, ensuring traffic separation, and therefore less likely to be accepted than requests informed by surrounding traffic and that avoids creating conflicts. This paper studies the benefits of providing aircrews with on-board decision support to generate optimized trajectory requests that are probed and cleared of known separation violations prior to issuing the request to ATC. These informed requests are referred to as traffic aware strategic aircrew requests (TASAR) and leverage traffic surveillance information available through Automatic Dependent Surveillance Broadcast (ADS-B) In capability. Preliminary fast-time simulation results show increased benefits with longer stage lengths since beneficial trajectory changes can be applied over a longer distance. Also, larger benefits were experienced between large hub airports as compared to other airport sizes. On average, an aircraft equipped with TASAR reduced its travel time by about one to four minutes per operation and fuel burn by about 50 to 550 lbs per operation depending on the objective of the aircrew (time, fuel, or weighted combination of time and fuel), class of airspace user, and aircraft type. These preliminary results are based on analysis of approximately one week of traffic in July 2012 and additional analysis is planned on a larger data set to confirm these initial findings.

Ares-I-X Vehicle Preliminary Range Safety Malfunction Turn Analysis

NASA Technical Reports Server (NTRS)

Beaty, James R.; Starr, Brett R.; Gowan, John W., Jr.

2008-01-01

Ares-I-X is the designation given to the flight test version of the Ares-I rocket (also known as the Crew Launch Vehicle - CLV) being developed by NASA. As part of the preliminary flight plan approval process for the test vehicle, a range safety malfunction turn analysis was performed to support the launch area risk assessment and vehicle destruct criteria development processes. Several vehicle failure scenarios were identified which could cause the vehicle trajectory to deviate from its normal flight path, and the effects of these failures were evaluated with an Ares-I-X 6 degrees-of-freedom (6-DOF) digital simulation, using the Program to Optimize Simulated Trajectories Version 2 (POST2) simulation framework. The Ares-I-X simulation analysis provides output files containing vehicle state information, which are used by other risk assessment and vehicle debris trajectory simulation tools to determine the risk to personnel and facilities in the vicinity of the launch area at Kennedy Space Center (KSC), and to develop the vehicle destruct criteria used by the flight test range safety officer. The simulation analysis approach used for this study is described, including descriptions of the failure modes which were considered and the underlying assumptions and ground rules of the study, and preliminary results are presented, determined by analysis of the trajectory deviation of the failure cases, compared with the expected vehicle trajectory.

Regional-scale brine migration along vertical pathways due to CO2 injection - Part 1: The participatory modeling approach

NASA Astrophysics Data System (ADS)

Scheer, Dirk; Konrad, Wilfried; Class, Holger; Kissinger, Alexander; Knopf, Stefan; Noack, Vera

2017-06-01

Saltwater intrusion into potential drinking water aquifers due to the injection of CO2 into deep saline aquifers is one of the potential hazards associated with the geological storage of CO2. Thus, in a site selection process, models for predicting the fate of the displaced brine are required, for example, for a risk assessment or the optimization of pressure management concepts. From the very beginning, this research on brine migration aimed at involving expert and stakeholder knowledge and assessment in simulating the impacts of injecting CO2 into deep saline aquifers by means of a participatory modeling process. The involvement exercise made use of two approaches. First, guideline-based interviews were carried out, aiming at eliciting expert and stakeholder knowledge and assessments of geological structures and mechanisms affecting CO2-induced brine migration. Second, a stakeholder workshop including the World Café format yielded evaluations and judgments of the numerical modeling approach, scenario selection, and preliminary simulation results. The participatory modeling approach gained several results covering brine migration in general, the geological model sketch, scenario development, and the review of the preliminary simulation results. These results were included in revised versions of both the geological model and the numerical model, helping to improve the analysis of regional-scale brine migration along vertical pathways due to CO2 injection.

Impact of structural optimization with aeroelastic/multidisciplinary constraints on helicopter rotor design

NASA Technical Reports Server (NTRS)

Friedmann, Peretz P.

1992-01-01

This paper presents a review of the state-of-the-art in the field of structural optimization when applied to vibration reduction of helicopters in forward flight with aeroelastic and multidisciplinary constraints. It emphasizes the application of the modern approach where the optimization is formulated as a mathematical programming problem and the objective function consists of the vibration levels at the hub and behavior constraints are imposed on the blade frequencies, aeroelastic stability margins as well as on a number of additional ingredients which can have a significant effect on the overall performance and flight mechanics of the helicopter. It is shown that the integrated multidisciplinary optimization of rotorcraft offers the potential for substantial improvements which can be achieved by careful preliminary design and analysis without requiring additional hardware such as rotor vibration absorbers or isolation systems.

Helicopter vibration reduction using structural optimization with aeroelastic/multidisciplinary constraints - A survey

NASA Technical Reports Server (NTRS)

Friedmann, Peretz P.

1991-01-01

This paper presents a survey of the state-of-the-art in the field of structural optimization when applied to vibration reduction of helicopters in forward flight with aeroelastic and multidisciplinary constraints. It emphasizes the application of the modern approach where the optimization is formulated as a mathematical programming problem, the objective function consists of the vibration levels at the hub, and behavior constraints are imposed on the blade frequencies and aeroelastic stability margins, as well as on a number of additional ingredients that can have a significant effect on the overall performance and flight mechanics of the helicopter. It is shown that the integrated multidisciplinary optimization of rotorcraft offers the potential for substantial improvements, which can be achieved by careful preliminary design and analysis without requiring additional hardware such as rotor vibration absorbers of isolation systems.

Preliminary Development of an Object-Oriented Optimization Tool

NASA Technical Reports Server (NTRS)

Pak, Chan-gi

2011-01-01

The National Aeronautics and Space Administration Dryden Flight Research Center has developed a FORTRAN-based object-oriented optimization (O3) tool that leverages existing tools and practices and allows easy integration and adoption of new state-of-the-art software. The object-oriented framework can integrate the analysis codes for multiple disciplines, as opposed to relying on one code to perform analysis for all disciplines. Optimization can thus take place within each discipline module, or in a loop between the central executive module and the discipline modules, or both. Six sample optimization problems are presented. The first four sample problems are based on simple mathematical equations; the fifth and sixth problems consider a three-bar truss, which is a classical example in structural synthesis. Instructions for preparing input data for the O3 tool are presented.

Quality of care of patients with type 1 diabetes: population-based results in a French region.

PubMed

Penfornis, A; Personeni, E; Tiv, M; Monnier, C; Meillet, L; Combes, J; Mouret, C; Picard, S

2012-11-01

Although the incidence of type 1 diabetes (T1D) has been increasing, little is known of its quality of care. Thus, our survey was designed to retrospectively evaluate this issue in French patients. Patients with T1D living in northeastern France were identified thanks to the healthcare system (CPAM) database, and the resulting list reviewed by local diabetes specialists. All of the listed patients and their primary physicians were asked to fill in a questionnaire including clinical data, laboratory results and follow-up habits. The 'optimized results' included CPAM-based results plus any specialized care provided during hospitalizations in diabetes and non-diabetes units, according to questionnaire data. A total of 227 individuals, for whom CPAM data were available, were identified as having T1D. From these patients, 174 questionnaires were answered, and optimized results (having both CPAM data and a completely filled-in questionnaire) were available for 149 patients. Of the 169 patients who responded, 71.3% reported at least a yearly visit with a diabetologist. This number reached 77.9% when optimized results were considered. Patients who received specialized care were younger, underwent HbA(1c) tests more often and were more frequently on optimal treatment; however, there was no difference in HbA(1c) values or in the prevalence of complications. Eye examinations and kidney tests had been performed at least once over the 2-year period in more than 87% of the patients, whereas around 30%, 21% and 23% had an eye exam, creatinine test and urinary albumin excretion measurement, respectively, only once over the same time period. This is the first large-scale study of the quality of care in patients with T1DM in France, and it could serve as a preliminary survey for a national study. Although the follow-up was better than previously reported, there is still considerable room for improvement. Copyright © 2012. Published by Elsevier Masson SAS.

76 FR 79655 - Honey From Argentina: Notice of Extension of Time Limit for Preliminary Results

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

... of Extension of Time Limit for Preliminary Results AGENCY: Import Administration, International Trade... preliminary results of this administrative review to no later than January 3, 2012. DATES: Effective Date... Initiation Notice. On September 7, 2011, the Department extended the time limit for the preliminary results...

76 FR 76374 - Honey From Argentina: Notice of Extension of Time Limit for Preliminary Results

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-07

... of Extension of Time Limit for Preliminary Results AGENCY: Import Administration, International Trade... preliminary results of this administrative review to no later than December 15, 2011. DATES: Effective Date... Initiation Notice. On September 7, 2011, the Department extended the time limit for the preliminary results...

75 FR 39207 - Purified Carboxymethylcellulose From Finland: Extension of Time Limit for Preliminary Results of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-08

... Carboxymethylcellulose From Finland: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative...: Extension of Time Limit for Preliminary Results of Antidumping Duty Administrative Review, 75 FR 3444... than July 7, 2010. Extension of Time Limits for Preliminary Results Section 751(a)(3)(A) of the Tariff...

An effective and comprehensive model for optimal rehabilitation of separate sanitary sewer systems.

PubMed

Diogo, António Freire; Barros, Luís Tiago; Santos, Joana; Temido, Jorge Santos

2018-01-15

In the field of rehabilitation of separate sanitary sewer systems, a large number of technical, environmental, and economic aspects are often relevant in the decision-making process, which may be modelled as a multi-objective optimization problem. Examples are those related with the operation and assessment of networks, optimization of structural, hydraulic, sanitary, and environmental performance, rehabilitation programmes, and execution works. In particular, the cost of investment, operation and maintenance needed to reduce or eliminate Infiltration from the underground water table and Inflows of storm water surface runoff (I/I) using rehabilitation techniques or related methods can be significantly lower than the cost of transporting and treating these flows throughout the lifespan of the systems or period studied. This paper presents a comprehensive I/I cost-benefit approach for rehabilitation that explicitly considers all elements of the systems and shows how the approximation is incorporated as an objective function in a general evolutionary multi-objective optimization model. It takes into account network performance and wastewater treatment costs, average values of several input variables, and rates that can reflect the adoption of different predictable or limiting scenarios. The approach can be used as a practical and fast tool to support decision-making in sewer network rehabilitation in any phase of a project. The fundamental aspects, modelling, implementation details and preliminary results of a two-objective optimization rehabilitation model using a genetic algorithm, with a second objective function related to the structural condition of the network and the service failure risk, are presented. The basic approach is applied to three real world cases studies of sanitary sewerage systems in Coimbra and the results show the simplicity, suitability, effectiveness, and usefulness of the approximation implemented and of the objective function proposed. Copyright © 2017 Elsevier B.V. All rights reserved.

Can Structural Optimization Explain Slow Dynamics of Rocks?

NASA Astrophysics Data System (ADS)

Kim, H.; Vistisen, O.; Tencate, J. A.

2009-12-01

Slow dynamics is a recovery process that describes the return to an equilibrium state after some external energy input is applied and then removed. Experimental studies on many rocks have shown that a modest acoustic energy input results in slow dynamics. The recovery process of the stiffness has consistently been found to be linear to log(time) for a wide range of geomaterials and the time constants appear to be unique to the material [TenCate JA, Shankland TJ (1996), Geophys Res Lett 23, 3019-3022]. Measurements of this nonequilibrium effect in rocks (e.g. sandstones and limestones) have been linked directly to the cement holding the individual grains together [Darling TW, TenCate JA, Brown DW, Clausen B, Vogel SC (2004), Geophys Res Lett 31, L16604], also suggesting a potential link to porosity and permeability. Noting that slow dynamics consistently returns the overall stiffness of rocks to its maximum (original) state, it is hypothesized that the original state represents the global minimum strain energy state. Consequently the slow dynamics process represents the global minimization or optimization process. Structural optimization, which has been developed for engineering design, minimises the total strain energy by rearranging the material distribution [Kim H, Querin OM, Steven GP, Xie YM (2002), Struct Multidiscip Optim 24, 441-448]. The optimization process effectively rearranges the way the material is cemented. One of the established global optimization methods is simulated annealing (SA). Derived from cooling of metal to a thermal equilibrium, SA finds an optimum solution by iteratively moving the system towards the minimum energy state with a probability of 'uphill' moves. It has been established that the global optimum can be guaranteed by applying a log(time) linear cooling schedule [Hajek B (1988, Math Ops Res, 15, 311-329]. This work presents the original study of applying SA to the maximum stiffness optimization problem. Preliminary results indicate that the maximum stiffness solutions are achieved when using log(time) linear cooling schedule. The optimization history reveals that the overall stiffness of the structure is increased linearly to log(time). The results closely resemble the slow dynamics stiffness recovery of geomaterials and support the hypothesis that the slow dynamics is an optimization process for strain energy. [Work supported by the Department of Energy through the LANL/LDRD Program].

High-Intensity Interval Training After Stroke: An Opportunity to Promote Functional Recovery, Cardiovascular Health, and Neuroplasticity.

PubMed

Crozier, Jennifer; Roig, Marc; Eng, Janice J; MacKay-Lyons, Marilyn; Fung, Joyce; Ploughman, Michelle; Bailey, Damian M; Sweet, Shane N; Giacomantonio, Nicholas; Thiel, Alexander; Trivino, Michael; Tang, Ada

2018-04-01

Stroke is the leading cause of adult disability. Individuals poststroke possess less than half of the cardiorespiratory fitness (CRF) as their nonstroke counterparts, leading to inactivity, deconditioning, and an increased risk of cardiovascular events. Preserving cardiovascular health is critical to lower stroke risk; however, stroke rehabilitation typically provides limited opportunity for cardiovascular exercise. Optimal cardiovascular training parameters to maximize recovery in stroke survivors also remains unknown. While stroke rehabilitation recommendations suggest the use of moderate-intensity continuous exercise (MICE) to improve CRF, neither is it routinely implemented in clinical practice, nor is the intensity always sufficient to elicit a training effect. High-intensity interval training (HIIT) has emerged as a potentially effective alternative that encompasses brief high-intensity bursts of exercise interspersed with bouts of recovery, aiming to maximize cardiovascular exercise intensity in a time-efficient manner. HIIT may provide an alternative exercise intervention and invoke more pronounced benefits poststroke. To provide an updated review of HIIT poststroke through ( a) synthesizing current evidence; ( b) proposing preliminary considerations of HIIT parameters to optimize benefit; ( c) discussing potential mechanisms underlying changes in function, cardiovascular health, and neuroplasticity following HIIT; and ( d) discussing clinical implications and directions for future research. Preliminary evidence from 10 studies report HIIT-associated improvements in functional, cardiovascular, and neuroplastic outcomes poststroke; however, optimal HIIT parameters remain unknown. Larger randomized controlled trials are necessary to establish ( a) effectiveness, safety, and optimal training parameters within more heterogeneous poststroke populations; (b) potential mechanisms of HIIT-associated improvements; and ( c) adherence and psychosocial outcomes.

SU-E-T-632: Preliminary Study On Treating Nose Skin Using Energy and Intensity Modulated Electron Beams with Monte Carlo Based Dose Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, L; Eldib, A; Li, J

Purpose: Uneven nose surfaces and air cavities underneath and the use of bolus present complexity and dose uncertainty when using a single electron energy beam to plan treatments of nose skin with a pencil beam-based planning system. This work demonstrates more accurate dose calculation and more optimal planning using energy and intensity modulated electron radiotherapy (MERT) delivered with a pMLC. Methods: An in-house developed Monte Carlo (MC)-based dose calculation/optimization planning system was employed for treatment planning. Phase space data (6, 9, 12 and 15 MeV) were used as an input source for MC dose calculations for the linac. To reducemore » the scatter-caused penumbra, a short SSD (61 cm) was used. Our previous work demonstrates good agreement in percentage depth dose and off-axis dose between calculations and film measurement for various field sizes. A MERT plan was generated for treating the nose skin using a patient geometry and a dose volume histogram (DVH) was obtained. The work also shows the comparison of 2D dose distributions between a clinically used conventional single electron energy plan and the MERT plan. Results: The MERT plan resulted in improved target dose coverage as compared to the conventional plan, which demonstrated a target dose deficit at the field edge. The conventional plan showed higher dose normal tissue irradiation underneath the nose skin while the MERT plan resulted in improved conformity and thus reduces normal tissue dose. Conclusion: This preliminary work illustrates that MC-based MERT planning is a promising technique in treating nose skin, not only providing more accurate dose calculation, but also offering an improved target dose coverage and conformity. In addition, this technique may eliminate the necessity of bolus, which often produces dose delivery uncertainty due to the air gaps that may exist between the bolus and skin.« less

Application of the generalized reduced gradient method to conceptual aircraft design

NASA Technical Reports Server (NTRS)

Gabriele, G. A.

1984-01-01

The complete aircraft design process can be broken into three phases of increasing depth: conceptual design, preliminary design, and detail design. Conceptual design consists primarily of developing general arrangements and selecting the configuration that optimally satisfies all mission requirements. The result of the conceptual phase is a conceptual baseline configuration that serves as the starting point for the preliminary design phase. The conceptual design of an aircraft involves a complex trade-off of many independent variables that must be investigated before deciding upon the basic configuration. Some of these variables are discrete (number of engines), some represent different configurations (canard vs conventional tail) and some may represent incorporation of new technologies (aluminum vs composite materials). At Lockheed-Georgia, the sizing program is known as GASP (Generalized Aircraft Sizing Program). GASP is a large program containing analysis modules covering the many different disciplines involved fin defining the aricraft, such as aerodynamics, structures, stability and control, mission performance, and cost. These analysis modules provide first-level estimates the aircraft properties that are derived from handbook, experimental, and historical sources.

Genetic programming based models in plant tissue culture: An addendum to traditional statistical approach.

PubMed

Mridula, Meenu R; Nair, Ashalatha S; Kumar, K Satheesh

2018-02-01

In this paper, we compared the efficacy of observation based modeling approach using a genetic algorithm with the regular statistical analysis as an alternative methodology in plant research. Preliminary experimental data on in vitro rooting was taken for this study with an aim to understand the effect of charcoal and naphthalene acetic acid (NAA) on successful rooting and also to optimize the two variables for maximum result. Observation-based modelling, as well as traditional approach, could identify NAA as a critical factor in rooting of the plantlets under the experimental conditions employed. Symbolic regression analysis using the software deployed here optimised the treatments studied and was successful in identifying the complex non-linear interaction among the variables, with minimalistic preliminary data. The presence of charcoal in the culture medium has a significant impact on root generation by reducing basal callus mass formation. Such an approach is advantageous for establishing in vitro culture protocols as these models will have significant potential for saving time and expenditure in plant tissue culture laboratories, and it further reduces the need for specialised background.

Innovative thin silicon detectors for monitoring of therapeutic proton beams: preliminary beam tests

NASA Astrophysics Data System (ADS)

Vignati, A.; Monaco, V.; Attili, A.; Cartiglia, N.; Donetti, M.; Fadavi Mazinani, M.; Fausti, F.; Ferrero, M.; Giordanengo, S.; Hammad Ali, O.; Mandurrino, M.; Manganaro, L.; Mazza, G.; Sacchi, R.; Sola, V.; Staiano, A.; Cirio, R.; Boscardin, M.; Paternoster, G.; Ficorella, F.

2017-12-01

To fully exploit the physics potentials of particle therapy in delivering dose with high accuracy and selectivity, charged particle therapy needs further improvement. To this scope, a multidisciplinary project (MoVeIT) of the Italian National Institute for Nuclear Physics (INFN) aims at translating research in charged particle therapy into clinical outcome. New models in the treatment planning system are being developed and validated, using dedicated devices for beam characterization and monitoring in radiobiological and clinical irradiations. Innovative silicon detectors with internal gain layer (LGAD) represent a promising option, overcoming the limits of currently used ionization chambers. Two devices are being developed: one to directly count individual protons at high rates, exploiting the large signal-to-noise ratio and fast collection time in small thicknesses (1 ns in 50 μm) of LGADs, the second to measure the beam energy with time-of-flight techniques, using LGADs optimized for excellent time resolutions (Ultra Fast Silicon Detectors, UFSDs). The preliminary results of first beam tests with therapeutic beam will be presented and discussed.

A six-degree-of-freedom passive arm with dynamic constraints (PADyC) for cardiac surgery application: preliminary experiments.

PubMed

Schneider, O; Troccaz, J

2001-01-01

The purpose of Computer-Assisted Surgery (CAS) is to help physicians and surgeons plan and execute optimal strategies from multimodal image data. The execution of such planned strategies may be assisted by guidance systems. Some of these systems, called synergistic systems, are based on the cooperation of a robotic device with a human operator. We have developed such a synergistic device: PADyC (Passive Arm with Dynamic Constraints). The basic principle of PADyC is to have a manually actuated arm that dynamically constrains the authorized motions of the surgical tool held by the human operator during a planned task. Dynamic constraints are computed from the task definition, and are implemented by a patented mechanical system. In this paper, we first introduce synergistic systems and then focus on modeling and algorithmic issues related to the dynamic constraints. Finally, we describe a 6-degree-of-freedom prototype robot designed for a clinical application (cardiac surgery) and report on preliminary experiments to date. The experimental results are then discussed, and future work is proposed. Copyright 2002 Wiley-Liss, Inc.

Microcatheter Shaping for Intracranial Aneurysm Coiling Using the 3-Dimensional Printing Rapid Prototyping Technology: Preliminary Result in the First 10 Consecutive Cases.

PubMed

Namba, Katsunari; Higaki, Ayuho; Kaneko, Naoki; Mashiko, Toshihiro; Nemoto, Shigeru; Watanabe, Eiju

2015-07-01

An optimal microcatheter is necessary for successful coiling of an intracranial aneurysm. The optimal shape may be predetermined before the endovascular surgery via the use of a 3-dimensional (3D) printing rapid prototyping technology. We report a preliminary series of intracranial aneurysms treated with a microcatheter shape determined by the patient's anatomy and configuration of the aneurysm, which was fabricated with a 3D printer aneurysm model. A solid aneurysm model was fabricated with a 3D printer based on the data acquired from the 3D rotational angiogram. A hollow aneurysm model with an identical vessel and aneurysm lumen to the actual anatomy was constructed with use of the solid model as a mold. With use of the solid model, a microcatheter shaping mandrel was formed to identically line the 3D curvature of the parent vessel and the long axis of the aneurysm. With use of the mandrel, a test microcatheter was shaped and validated for the accuracy with the hollow model. All the planning processes were undertaken at least 1 day before treatment. The preshaped mandrel was then applied in the endovascular procedure. Ten consecutive intracranial aneurysms were coiled with the pre-planned shape of the microcatheter and evaluated for the clinical and anatomical outcomes and microcatheter accuracy and stability. All of pre-planned microcatheters matched the vessel and aneurysm anatomy. Seven required no microguidewire assistance in catheterizing the aneurysm whereas 3 required guiding of a microguidewire. All of the microcatheters accurately aligned the long axis of the aneurysm. The pre-planned microcatheter shapes demonstrated stability in all except in 1 large aneurysm case. When a 3D printing rapid type prototyping technology is used, a patient-specific and optimal microcatheter shape may be determined preoperatively. Copyright © 2015 Elsevier Inc. All rights reserved.

Development and Application of a Tool for Optimizing Composite Matrix Viscoplastic Material Parameters

NASA Technical Reports Server (NTRS)

Murthy, Pappu L. N.; Naghipour Ghezeljeh, Paria; Bednarcyk, Brett A.

2018-01-01

This document describes a recently developed analysis tool that enhances the resident capabilities of the Micromechanics Analysis Code with the Generalized Method of Cells (MAC/GMC) and its application. MAC/GMC is a composite material and laminate analysis software package developed at NASA Glenn Research Center. The primary focus of the current effort is to provide a graphical user interface (GUI) capability that helps users optimize highly nonlinear viscoplastic constitutive law parameters by fitting experimentally observed/measured stress-strain responses under various thermo-mechanical conditions for braided composites. The tool has been developed utilizing the MATrix LABoratory (MATLAB) (The Mathworks, Inc., Natick, MA) programming language. Illustrative examples shown are for a specific braided composite system wherein the matrix viscoplastic behavior is represented by a constitutive law described by seven parameters. The tool is general enough to fit any number of experimentally observed stress-strain responses of the material. The number of parameters to be optimized, as well as the importance given to each stress-strain response, are user choice. Three different optimization algorithms are included: (1) Optimization based on gradient method, (2) Genetic algorithm (GA) based optimization and (3) Particle Swarm Optimization (PSO). The user can mix and match the three algorithms. For example, one can start optimization with either 2 or 3 and then use the optimized solution to further fine tune with approach 1. The secondary focus of this paper is to demonstrate the application of this tool to optimize/calibrate parameters for a nonlinear viscoplastic matrix to predict stress-strain curves (for constituent and composite levels) at different rates, temperatures and/or loading conditions utilizing the Generalized Method of Cells. After preliminary validation of the tool through comparison with experimental results, a detailed virtual parametric study is presented wherein the combined effects of temperature and loading rate on the predicted response of a braided composite is investigated.

Optimization of extraction and antioxidant activity of polysaccharides from Salvia miltiorrhiza Bunge residue.

PubMed

Jiang, Yuanyuan; Wang, Long; Zhang, Li; Wang, Tao; Zhou, Yonghong; Ding, Chunbang; Yang, Ruiwu; Wang, Xiaoli; Yu, Lin

2015-08-01

In this study, the process of extracting polysaccharides from Salvia miltiorrhiza Bunge residue was optimized by using a Box-Behnken design. Statistical analysis of the results showed that the linear and quadratic terms of the three variables of the extraction process had significant effects. The optimal conditions are as follows: extracting time of 2.6 h, extraction temperature of 89 °C, and ratio of water to raw material of 32 mL/g. Moreover, a new polysaccharide with antioxidant activity [i.e., SMWP-1 (∼5.27×10(5) Da)] was isolated from S. miltiorrhiza residue. The carbohydrate, uronic acid, and protein contents of SMWP-1 were 90.11%, 0.13%, and 0.53%, respectively. The SMWP-1 is composed of glucose, xylose, mannose, and galactose. The preliminary structural characterization of SMWP-1 was determined via Fourier transform infrared (FTIR) spectroscopy, and scanning electron microscopy (SEM) analyses. This polysaccharide exhibited strong reducing power and free-radical scavenging activities in vitro against 2,2-diphenyl-1-picrylhydrazyl, superoxide anion, and hydroxyl. Therefore, SMWP-1 can be investigated further as a novel natural antioxidant. Copyright © 2015 Elsevier B.V. All rights reserved.

Optimized Autonomous Space - In-situ Sensorweb: A new Tool for Monitoring Restless Volcanoes

NASA Astrophysics Data System (ADS)

Lahusen, R. G.; Kedar, S.; Song, W.; Chien, S.; Shirazi, B.; Davies, A.; Tran, D.; Pieri, D.

2007-12-01

An interagency team of earth scientists, space scientists and computer scientists are collaborating to develop a real-time monitoring system optimized for rapid deployment at restless volcanoes. The primary goals of this Optimized Autonomous Space In-situ Sensorweb (OASIS) are: 1) integrate complementary space and in-situ (ground-based) elements into an interactive, autonomous sensorweb; 2) advance sensorweb power and communication resource management technology; and 3) enable scalability for seamless infusion of future space and in-situ assets into the sensorweb. A prototype system will be deployed on Mount St. Helens by December 2009. Each node will include GPS, seismic, infrasonic and lightning (for ash plume detection) sensors plus autonomous decision making capabilities and interaction with EO-1 multi-spectral satellite. This three year project is jointly funded by NASA AIST program and USGS Volcano Hazards Program. Work has begun with a rigorous multi-disciplinary discussion and resulted in a system requirements document aimed to guide the design of OASIS and future networks and to achieve the project's stated goals. In this presentation we will highlight the key OASIS system requirements, their rationale and the physical and technical challenges they pose. Preliminary design decisions will be presented.

Batch and Continuous Ultrasound Assisted Extraction of Boldo Leaves (Peumus boldus Mol.).

PubMed

Petigny, Loïc; Périno-Issartier, Sandrine; Wajsman, Joël; Chemat, Farid

2013-03-12

Vegetal extracts are widely used as primary ingredients for various products from creams to perfumes in the pharmaceutical, nutraceutic and cosmetic industries. Having concentrated and active extract is essential, as the process must extract as much soluble material as possible in a minimum time, using the least possible volume of solvent. The boldo leaves extract is of great interest for the industry as it holds a great anti-oxidant activity due to high levels of flavonoids and alkaloids such as boldine. Ultrasound Assisted Extraction (UAE) has been used to improve the efficiency of the plant extraction, reducing extraction time, increasing the concentration of the extract with the same amount of solvent and plant material. After a preliminary study, a response surface method has been used to optimize the extraction of soluble material from the plant. The results provided by the statistical analysis revealed that the optimized conditions were: sonication power 23 W/cm2 for 40 min and a temperature of 36 °C. The optimized parameters of the UAE provide a better extraction compared to a conventional maceration in terms of process time (30 min instead of 120 min), higher yield, more energy saving, cleanliness, safety and product quality.

Batch and Continuous Ultrasound Assisted Extraction of Boldo Leaves (Peumus boldus Mol.)

PubMed Central

Petigny, Loïc; Périno-Issartier, Sandrine; Wajsman, Joël; Chemat, Farid

2013-01-01

Vegetal extracts are widely used as primary ingredients for various products from creams to perfumes in the pharmaceutical, nutraceutic and cosmetic industries. Having concentrated and active extract is essential, as the process must extract as much soluble material as possible in a minimum time, using the least possible volume of solvent. The boldo leaves extract is of great interest for the industry as it holds a great anti-oxidant activity due to high levels of flavonoids and alkaloids such as boldine. Ultrasound Assisted Extraction (UAE) has been used to improve the efficiency of the plant extraction, reducing extraction time, increasing the concentration of the extract with the same amount of solvent and plant material. After a preliminary study, a response surface method has been used to optimize the extraction of soluble material from the plant. The results provided by the statistical analysis revealed that the optimized conditions were: sonication power 23 W/cm2 for 40 min and a temperature of 36 °C. The optimized parameters of the UAE provide a better extraction compared to a conventional maceration in terms of process time (30 min instead of 120 min), higher yield, more energy saving, cleanliness, safety and product quality. PMID:23481637

Optimization of robotic welding procedures for maintenance repair of hydraulic turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamarche, L.; Galopin, M.; Simoneau, R.

1996-12-31

A six axes super-compact robot is used for field repair of cavitation damages found on the discharge ring of hydraulic turbines. Optimization of overlay welding procedures to minimize surface distortion and reduce tearing forces on anchors in concrete, were studied through experimentation and FEM modelling. Planned experimentation has been used to develop optimum pulsed GMAW schedules of stainless steel overlays in 2G position. Best welding sequence was resolved through over lay welding of free plates. Each overlay consisted in one or two layers which were welded in the longitudinal and/or transverse direction of the rectangular plate. A bidirectional welding mode,more » a longitudinal layer followed by a transverse layer position and no cooling between the two layers, were found to be most effective in reducing distortion. The optimized 2G welding procedure was applied to a simulated field repair. Plate was anchored on a massive iron bracket with a set of instrumented bolts, to understand how normal tearing forces in anchors evolve. Preliminary results on FEM modelling of lateral force on anchors indicate good correlation with experiments, for an elementary design.« less

Preliminary design of a superconducting coil array for NASA prototype magnetic balance. M.S. Thesis

NASA Technical Reports Server (NTRS)

Alishahi, M. M.

1980-01-01

Using a computer program a partly optimized configuration for a supeconducting version of side and lift coil system of NASA-MIT prototype is presented. Cable size for the mentioned coils and also for superconducting drag and magnetizing coils regarding the overall computed field was determined.

Student Acceptance of the TICCIT System: A Preliminary Study.

ERIC Educational Resources Information Center

Asay, Calvin S.; Schneider, Edward W.

Twenty male and female students from a high school psychology class participated in a formative evaluation of student acceptance and performance with the Primary Instruction Logic of the TICCIT delivery system. A secondary goal was a pilot effort to design a carrel that would optimize certain parameters of the physical/environmental conditions…

Detection of Prostate Cancer Progression by Serum DNA Integrity

DTIC Science & Technology

2010-04-01

qRT) Alu and direct qRT LINE1 is being optimized. We will also continue to develop circulating DNA methylated GSTP1 assay to complement the DNA...developed the LINE1 assay, assembled the manuscript on uLINE1, and performed preliminary analysis of circulating DNA GSTP1 methylation. The goal is to

Mod-2 wind turbine system concept and preliminary design report. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1979-01-01

The configuration development of the MOD-2 wind turbine system is presented. The MOD-2 is design optimized for commercial production rates which, in multi-unit installations, will be integrated into a utility power grid and achieve a cost of electricity at less than 4 cents per kilowatt hour.

Community Design for Optimal Energy and Resource Utilization.

ERIC Educational Resources Information Center

Bilenky, Stephen; And Others

Presented is a study which investigated the energy and resource dynamics of a semi-autonomous domestic system for 30 people. The investigation is organized on three levels: (1) developing a preliminary design and design parameters; (2) development and quantification of the energy and resource dynamics; and (3) designing a model to extrapolate…

Bimodal Nuclear Thermal Rocket Sizing and Trade Matrix for Lunar, Near Earth Asteroid and Mars Missions

NASA Astrophysics Data System (ADS)

McCurdy, David R.; Krivanek, Thomas M.; Roche, Joseph M.; Zinolabedini, Reza

2006-01-01

The concept of a human rated transport vehicle for various near earth missions is evaluated using a liquid hydrogen fueled Bimodal Nuclear Thermal Propulsion (BNTP) approach. In an effort to determine the preliminary sizing and optimal propulsion system configuration, as well as the key operating design points, an initial investigation into the main system level parameters was conducted. This assessment considered not only the performance variables but also the more subjective reliability, operability, and maintainability attributes. The SIZER preliminary sizing tool was used to facilitate rapid modeling of the trade studies, which included tank materials, propulsive versus an aero-capture trajectory, use of artificial gravity, reactor chamber operating pressure and temperature, fuel element scaling, engine thrust rating, engine thrust augmentation by adding oxygen to the flow in the nozzle for supersonic combustion, and the baseline turbopump configuration to address mission redundancy and safety requirements. A high level system perspective was maintained to avoid focusing solely on individual component optimization at the expense of system level performance, operability, and development cost.

PLA and two components silicon rubber blends aiming for frozen foods packaging applications

NASA Astrophysics Data System (ADS)

Meekum, Utai; Khiansanoi, Apichart

2018-03-01

Designing of PLA and two components silicone rubber blends was studies. Frozen food packaging application is the main ultimate aim. The statistical method using 23 DOE was conducted. The standard testing methods, in particular impact testing at sub-zero temperature, were performed. The preliminary blend formula comprised 1.0 phr of silane and polyester polyols, respectively, was initially resolved. Then, the optimize the silicone portion in the blends was determined. Blending formula using 8.0 phr of silicone with respect to PLA matrix gave rise to the overall satisfactory properties. 3. TETA was used as the silicone curing agent and reactively blended onto the ingredients. TETA at 0.4 phr, with respect to the silicone, enhanced the mechanical properties, especially flexibility and toughness, of the PLA/silicone blend. Exceeding the optimal TETA loading would cause the chain scission and also the dilution effects. Hence, marginal inferior properties of the blends were be experienced. The preliminary biodegradability investigation found that the PLA/silicone blend initially triggered at the second week. Its degradation rate was likely to be faster than neat PLA.

Designers' unified cost model

NASA Technical Reports Server (NTRS)

Freeman, W.; Ilcewicz, L.; Swanson, G.; Gutowski, T.

1992-01-01

The Structures Technology Program Office (STPO) at NASA LaRC has initiated development of a conceptual and preliminary designers' cost prediction model. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state-of-the-art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a database and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. This paper presents the team members, approach, goals, plans, and progress to date for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

Multi objective genetic algorithm to optimize the local heat treatment of a hardenable aluminum alloy

NASA Astrophysics Data System (ADS)

Piccininni, A.; Palumbo, G.; Franco, A. Lo; Sorgente, D.; Tricarico, L.; Russello, G.

2018-05-01

The continuous research for lightweight components for transport applications to reduce the harmful emissions drives the attention to the light alloys as in the case of Aluminium (Al) alloys, capable to combine low density with high values of the strength-to-weight ratio. Such advantages are partially counterbalanced by the poor formability at room temperature. A viable solution is to adopt a localized heat treatment by laser of the blank before the forming process to obtain a tailored distribution of material properties so that the blank can be formed at room temperature by means of conventional press machines. Such an approach has been extensively investigated for age hardenable alloys, but in the present work the attention is focused on the 5000 series; in particular, the optimization of the deep drawing process of the alloy AA5754 H32 is proposed through a numerical/experimental approach. A preliminary investigation was necessary to correctly tune the laser parameters (focus length, spot dimension) to effectively obtain the annealed state. Optimal process parameters were then obtained coupling a 2D FE model with an optimization platform managed by a multi-objective genetic algorithm. The optimal solution (i.e. able to maximize the LDR) in terms of blankholder force and extent of the annealed region was thus evaluated and validated through experimental trials. A good matching between experimental and numerical results was found. The optimal solution allowed to obtain an LDR of the locally heat treated blank larger than the one of the material either in the wrought condition (H32) either in the annealed condition (H111).

Optimization of a Lunar Pallet Lander Reinforcement Structure Using a Genetic Algorithm

NASA Technical Reports Server (NTRS)

Burt, Adam

2014-01-01

In this paper, a unique system level spacecraft design optimization will be presented. A Genetic Algorithm is used to design the global pattern of the reinforcing structure, while a gradient routine is used to adequately stiffen the sub-structure. The system level structural design includes determining the optimal physical location (and number) of reinforcing beams of a lunar pallet lander deck structure. Design of the substructure includes determining placement of secondary stiffeners and the number of rivets required for assembly.. In this optimization, several considerations are taken into account. The primary objective was to raise the primary natural frequencies of the structure such that the Pallet Lander primary structure does not significantly couple with the launch vehicle. A secondary objective is to determine how to properly stiffen the reinforcing beams so that the beam web resists the shear buckling load imparted by the spacecraft components mounted to the pallet lander deck during launch and landing. A third objective is that the calculated stress does not exceed the allowable strength of the material. These design requirements must be met while, minimizing the overall mass of the spacecraft. The final paper will discuss how the optimization was implemented as well as the results. While driven by optimization algorithms, the primary purpose of this effort was to demonstrate the capability of genetic algorithms to enable design automation in the preliminary design cycle. By developing a routine that can automatically generate designs through the use of Finite Element Analysis, considerable design efficiencies, both in time and overall product, can be obtained over more traditional brute force design methods.

Optimal systems of geoscience surveying A preliminary discussion

NASA Astrophysics Data System (ADS)

Shoji, Tetsuya

2006-10-01

In any geoscience survey, each survey technique must be effectively applied, and many techniques are often combined optimally. An important task is to get necessary and sufficient information to meet the requirement of the survey. A prize-penalty function quantifies effectiveness of the survey, and hence can be used to determine the best survey technique. On the other hand, an information-cost function can be used to determine the optimal combination of survey techniques on the basis of the geoinformation obtained. Entropy is available to evaluate geoinformation. A simple model suggests the possibility that low-resolvability techniques are generally applied at early stages of survey, and that higher-resolvability techniques should alternate with lower-resolvability ones with the progress of the survey.

Oncosurgical Management of Liver Limited Stage IV Colorectal Cancer: Preliminary Data and Protocol for a Randomized Controlled Trial.

PubMed

Sutton, Paul; Vimalachandran, Dale; Poston, Graeme; Fenwick, Stephen; Malik, Hassan

2018-05-09

Colorectal cancer is the fourth commonest cancer and second commonest cause of cancer-related death in the United Kingdom. Almost 15% of patients have metastases on presentation. An increasing number of surgical strategies and better neoadjuvant treatment options are responsible for more patients undergoing resection of liver metastases, with prolonged survival in a select group of patients who present with synchronous disease. It is clear that the optimal strategy for the management of these patients remains unclear, and there is certainly a complete absence of Level 1 evidence in the literature. The objective of this study is to undertake preliminary work and devise an outline trial protocol to inform the future development of clinical studies to investigate the management of patients with liver limited stage IV colorectal cancer. We have undertaken some preliminary work and begun the process of designing a randomized controlled trial and present a draft trial protocol here. This study is at the protocol development stage only, and as such no results are available. There is no funding in place for this study, and no anticipated start date. We have presented preliminary work and an outline trial protocol which we anticipate will inform the future development of clinical studies to investigate the management of patients with liver limited stage IV colorectal cancer. We do not believe that the trial we have designed will answer the most significant clinical questions, nor that it is feasible to be delivered within the United Kingdom's National Health Service at this current time. ©Paul Sutton, Dale Vimalachandran, Graeme Poston, Stephen Fenwick, Hassan Malik. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 09.05.2018.

Direct AUC optimization of regulatory motifs.

PubMed

Zhu, Lin; Zhang, Hong-Bo; Huang, De-Shuang

2017-07-15

The discovery of transcription factor binding site (TFBS) motifs is essential for untangling the complex mechanism of genetic variation under different developmental and environmental conditions. Among the huge amount of computational approaches for de novo identification of TFBS motifs, discriminative motif learning (DML) methods have been proven to be promising for harnessing the discovery power of accumulated huge amount of high-throughput binding data. However, they have to sacrifice accuracy for speed and could fail to fully utilize the information of the input sequences. We propose a novel algorithm called CDAUC for optimizing DML-learned motifs based on the area under the receiver-operating characteristic curve (AUC) criterion, which has been widely used in the literature to evaluate the significance of extracted motifs. We show that when the considered AUC loss function is optimized in a coordinate-wise manner, the cost function of each resultant sub-problem is a piece-wise constant function, whose optimal value can be found exactly and efficiently. Further, a key step of each iteration of CDAUC can be efficiently solved as a computational geometry problem. Experimental results on real world high-throughput datasets illustrate that CDAUC outperforms competing methods for refining DML motifs, while being one order of magnitude faster. Meanwhile, preliminary results also show that CDAUC may also be useful for improving the interpretability of convolutional kernels generated by the emerging deep learning approaches for predicting TF sequences specificities. CDAUC is available at: https://drive.google.com/drive/folders/0BxOW5MtIZbJjNFpCeHlBVWJHeW8 . dshuang@tongji.edu.cn. Supplementary data are available at Bioinformatics online. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Aerodynamic Shape Optimization of Supersonic Aircraft Configurations via an Adjoint Formulation on Parallel Computers

NASA Technical Reports Server (NTRS)

Reuther, James; Alonso, Juan Jose; Rimlinger, Mark J.; Jameson, Antony

1996-01-01

This work describes the application of a control theory-based aerodynamic shape optimization method to the problem of supersonic aircraft design. The design process is greatly accelerated through the use of both control theory and a parallel implementation on distributed memory computers. Control theory is employed to derive the adjoint differential equations whose solution allows for the evaluation of design gradient information at a fraction of the computational cost required by previous design methods (13, 12, 44, 38). The resulting problem is then implemented on parallel distributed memory architectures using a domain decomposition approach, an optimized communication schedule, and the MPI (Message Passing Interface) Standard for portability and efficiency. The final result achieves very rapid aerodynamic design based on higher order computational fluid dynamics methods (CFD). In our earlier studies, the serial implementation of this design method (19, 20, 21, 23, 39, 25, 40, 41, 42, 43, 9) was shown to be effective for the optimization of airfoils, wings, wing-bodies, and complex aircraft configurations using both the potential equation and the Euler equations (39, 25). In our most recent paper, the Euler method was extended to treat complete aircraft configurations via a new multiblock implementation. Furthermore, during the same conference, we also presented preliminary results demonstrating that the basic methodology could be ported to distributed memory parallel computing architectures [241. In this paper, our concem will be to demonstrate that the combined power of these new technologies can be used routinely in an industrial design environment by applying it to the case study of the design of typical supersonic transport configurations. A particular difficulty of this test case is posed by the propulsion/airframe integration.

Reverse total shoulder arthroplasty using helical blade to optimize glenoid fixation and bone preservation: preliminary results in thirty five patients with minimum two year follow-up.

PubMed

Zilber, Sebastien; Camana, Eleonora; Lapner, Peter; Haritinian, Emil; Nove Josserand, Laurent

2018-03-26

Glenoid loosening is a common cause of reverse total shoulder arthroplasty (RTSA) failure, and grafting of the glenoid is often required for revision due to bone loss due to the central peg in most glenoid baseplates. Helical blades have been used in the hip to optimize bone fixation in proximal femoral fracture. This study presents the initial results of specifically designed helical blade in the shoulder to optimize glenoid bone fixation and preservation as part of RTSA. Thirty-five patients underwent RTSA with glenoid helical blade fixation. An uncemented glenoid baseplate was used with a central helical blade partially coated with hydroxyapatite and two or three screws. Outcome analysis was performed pre-operatively and at two years. All patients were satisfied with the results and significant improvement was observed in functional outcome scores between baseline and final follow-up. There was a single intra-operative undisplaced glenoid fracture which did not compromise the baseplate fixation. There was no radiographic evidence of loosening or radiolucencies around the helical blade. The helical blade provides a satisfactory primary fixation. Because of its length (21 mm), care should be taken in cases of pre-existing bone loss or sclerotic bone to avoid glenoid fracture or anterior cortical perforation. Helical blade has the potential to facilitate glenoid implant revision by preserving the glenoid bone stock.

Potential of spark ignition engine for increased fuel efficiency. Final report, January-October 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, T. Jr.; Cole, D.; Bolt, J.A.

The objective of this study was to assess the potential of the spark ignition engine to deliver maximum fuel efficiency at 1981 Statutory Emission Standards in the 1983-1984 timeframe and beyond that to 1990. Based on the results of an extensive literature search, manufacturer's known product plans, and fuel economies of 1978 engines as a baseline, proposed methods of attaining fuel economy while complying with the future standards were ascertained. Methods of engine control optimization, engine design optimization as well as methods of varying engine parameters were considered. The potential improvements in fuel economy associated with these methods, singly andmore » in combination, were determined and are expressed as percentage changes of the fuel economy of the baseline engines. A summary of the principal conclusions are presented, followed by a description of the engine baseline reference, analysis and projection of fuel economy improvements, and a preliminary assessment of the impact of fuel economy benefits on manufacturing cost.« less

Optimization of ultrasound-assisted extraction to obtain mycosterols from Agaricus bisporus L. by response surface methodology and comparison with conventional Soxhlet extraction.

PubMed

Heleno, Sandrina A; Diz, Patrícia; Prieto, M A; Barros, Lillian; Rodrigues, Alírio; Barreiro, Maria Filomena; Ferreira, Isabel C F R

2016-04-15

Ergosterol, a molecule with high commercial value, is the most abundant mycosterol in Agaricus bisporus L. To replace common conventional extraction techniques (e.g. Soxhlet), the present study reports the optimal ultrasound-assisted extraction conditions for ergosterol. After preliminary tests, the results showed that solvents, time and ultrasound power altered the extraction efficiency. Using response surface methodology, models were developed to investigate the favourable experimental conditions that maximize the extraction efficiency. All statistical criteria demonstrated the validity of the proposed models. Overall, ultrasound-assisted extraction with ethanol at 375 W during 15 min proved to be as efficient as the Soxhlet extraction, yielding 671.5 ± 0.5mg ergosterol/100 g dw. However, with n-hexane extracts with higher purity (mg ergosterol/g extract) were obtained. Finally, it was proposed for the removal of the saponification step, which simplifies the extraction process and makes it more feasible for its industrial transference. Copyright © 2015 Elsevier Ltd. All rights reserved.

Flutter suppression control law synthesis for the Active Flexible Wing model

NASA Technical Reports Server (NTRS)

Mukhopadhyay, Vivek; Perry, Boyd, III; Noll, Thomas E.

1989-01-01

The Active Flexible Wing Project is a collaborative effort between the NASA Langley Research Center and Rockwell International. The objectives are the validation of methodologies associated with mathematical modeling, flutter suppression control law development and digital implementation of the control system for application to flexible aircraft. A flutter suppression control law synthesis for this project is described. The state-space mathematical model used for the synthesis included ten flexible modes, four control surface modes and rational function approximation of the doublet-lattice unsteady aerodynamics. The design steps involved developing the full-order optimal control laws, reducing the order of the control law, and optimizing the reduced-order control law in both the continuous and the discrete domains to minimize stochastic response. System robustness was improved using singular value constraints. An 8th order robust control law was designed to increase the symmetric flutter dynamic pressure by 100 percent. Preliminary results are provided and experiences gained are discussed.

Waveform Analysis Optimization for the 45Ca Beta Decay Experiment

NASA Astrophysics Data System (ADS)

Whitehead, Ryan; ⁴⁵Ca Collaboration

2017-09-01

The 45Ca experiment is searching for a non-zero Fierz interference term, which would imply a tensor type contribution to the low-energy weak interaction, possibly signaling Beyond-the-Standard-Model (BSM) physics. Beta spectrum measurements are being performed at LANL, using the segmented, large area, Si detectors developed for the Nab and UCNB experiments. 109 events have been recorded, with 38 of the 254 pixels instrumented, during the summers of 2016 and 2017. An important step to extracting the energy spectra is the correction of the waveform for pile-up events. A set of analysis tools has been developed to address this issue. A trapezoidal filter has been characterized and optimized for the experimental waveforms. This filter is primarily used for energy extraction, but, by adjusting certain parameters, it has been modified to identify pile-up events. The efficiency varies with the total energy of the particle and the amount deposited with each detector interaction. Preliminary results of this analysis will be presented.

Space Radiation Transport Methods Development

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Tripathi, R. K.; Qualls, G. D.; Cucinotta, F. A.; Prael, R. E.; Norbury, J. W.; Heinbockel, J. H.; Tweed, J.

2002-01-01

Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from the preliminary design concepts to the final design. In particular, we will discuss the progress towards a full three-dimensional and computationally efficient deterministic code for which the current HZETRN evaluates the lowest order asymptotic term. HZETRN is the first deterministic solution to the Boltzmann equation allowing field mapping within the International Space Station (ISS) in tens of minutes using standard Finite Element Method (FEM) geometry common to engineering design practice enabling development of integrated multidisciplinary design optimization methods. A single ray trace in ISS FEM geometry requires 14 milliseconds and severely limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given in terms of reconfigurable computing and could be utilized in the final design as verification of the deterministic method optimized design.

Grid sensitivity for aerodynamic optimization and flow analysis

NASA Technical Reports Server (NTRS)

Sadrehaghighi, I.; Tiwari, S. N.

1993-01-01

After reviewing relevant literature, it is apparent that one aspect of aerodynamic sensitivity analysis, namely grid sensitivity, has not been investigated extensively. The grid sensitivity algorithms in most of these studies are based on structural design models. Such models, although sufficient for preliminary or conceptional design, are not acceptable for detailed design analysis. Careless grid sensitivity evaluations, would introduce gradient errors within the sensitivity module, therefore, infecting the overall optimization process. Development of an efficient and reliable grid sensitivity module with special emphasis on aerodynamic applications appear essential. The organization of this study is as follows. The physical and geometric representations of a typical model are derived in chapter 2. The grid generation algorithm and boundary grid distribution are developed in chapter 3. Chapter 4 discusses the theoretical formulation and aerodynamic sensitivity equation. The method of solution is provided in chapter 5. The results are presented and discussed in chapter 6. Finally, some concluding remarks are provided in chapter 7.

SRM-Assisted Trajectory for the GTX Reference Vehicle

NASA Technical Reports Server (NTRS)

Riehl, John; Trefny, Charles; Kosareo, Daniel

2002-01-01

A goal of the GTX effort has been to demonstrate the feasibility of a single stage- to- orbit (SSTO) vehicle that delivers a small payload to low earth orbit. The small payload class was chosen in order to minimize the risk and cost of development of this revolutionary system. A preliminary design study by the GTX team has resulted in the current configuration that offers considerable promise for meeting the stated goal. The size and gross lift-off weight resulting from scaling the current design to closure however may be considered impractical for the small payload. In lieu of evolving the project's reference vehicle to a large-payload class, this paper offers the alternative of using solid-rocket motors in order to close the vehicle at a practical scale. This approach offers a near-term, quasi-reusable system that easily evolves to reusable SSTO following subsequent development and optimization. This paper presents an overview of the impact of the addition of SRM's to the GTX reference vehicle's performance and trajectory. The overall methods of vehicle modeling and trajectory optimization will also be presented. A key element in the trajectory optimization is the use of the program OTIS 3.10 that provides rapid convergence and a great deal of flexibility to the user. This paper will also present the methods used to implement GTX requirements into OTIS modeling.

SRM-Assisted Trajectory for the GTX Reference Vehicle

NASA Technical Reports Server (NTRS)

Riehl, John; Trefny, Charles; Kosareo, Daniel (Technical Monitor)

2002-01-01

A goal of the GTX effort has been to demonstrate the feasibility of a single stage-to-orbit (SSTO) vehicle that delivers a small payload to low earth orbit. The small payload class was chosen in order to minimize the risk and cost of development of this revolutionary system. A preliminary design study by the GTX team has resulted in the current configuration that offers considerable promise for meeting the stated goal. The size and gross lift-off weight resulting from scaling the current design to closure however may be considered impractical for the small payload. In lieu of evolving the project' reference vehicle to a large-payload class, this paper offers the alternative of using solid-rocket motors in order to close the vehicle at a practical scale. This approach offers a near-term, quasi-reusable system that easily evolves to reusable SSTO following subsequent development and optimization. This paper presents an overview of the impact of the addition of SRM's to the GTX reference vehicle#s performance and trajectory. The overall methods of vehicle modeling and trajectory optimization will also be presented. A key element in the trajectory optimization is the use of the program OTIS 3.10 that provides rapid convergence and a great deal of flexibility to the user. This paper will also present the methods used to implement GTX requirements into OTIS modeling.

Preliminary studies on SMA embedded wind turbine blades for passive control of vibration

NASA Astrophysics Data System (ADS)

Haghdoust, P.; Cinquemani, S.; Lo Conte, A.

2018-03-01

Wind turbine blades are being bigger and bigger, thus requiring lightweight structures that are more flexible and thus more sensitive to dynamic excitations and to vibration problems. This paper investigates a preliminary architecture of large wind turbine blades, embedding thin sheets of SMA to passively improve their total damping. A phenomenological material model is used for simulation of strain-dependent damping in SMA materials and an user defined material model was developed for this purpose. The response of different architectures of SMA embedded blades have been investigated in the time domain to find an optimal solution in which the less amount of SMA is used while the damping of the system is maximized

The New Year Wave: Generation, Propagation, Kinematics and Dynamics - Registered in a Seakeeping Basin

NASA Astrophysics Data System (ADS)

Clauss, Günther; Klein, Marco

2010-05-01

In the past years the existence of freak waves has been affirmed by observations, registrations, and severe accidents. One of the famous real world registrations is the so called 'New Year wave,' recorded in the North Sea at the Draupner jacket platform on January 1st, 1995. Since there is only a single point registration available, it is not possible to draw conclusions on the spatial development in front of and behind the point of registration, which is indispensable for a complete understanding of this phenomenon. This paper presents the temporal and spatial development of the New Year Wave generated in a model basin. To simulate the recorded New Year wave in the wave tank, an optimization approach for the experimental generation of wave sequences with predefined characteristics is used. The method is applied to generate scenarios with a single high wave superimposed to irregular seas. During the experimental optimization special emphasis is laid on the exact reproduction of the wave height, crest height, wave period, as well as the vertical and horizontal asymmetries of the New Year Wave. The fully automated optimization process is carried out in a small wave tank. At the beginning of the optimization process, the scaled real-sea measured sea state is transformed back to the position of the piston type wave generator by means of linear wave theory and by multiplication with the electrical and hydrodynamic transfer functions in the frequency domain. As a result a preliminary control signal for the wave generator is obtained. Due to nonlinear effects in the wave tank, the registration of the freak wave at the target position generated by this preliminary control signal deviates from the predefined target parameters. To improve the target wave in the tank only a short section of the control signal in time domain has to be adapted. For these temporally limited local changes in the control signal, the discrete wavelet transformation is introduced into the optimization process which samples the signal into several decomposition levels where each resulting coefficient describes the control signal in a specific time range and frequency bandwidth. To improve the control signal, the experimental optimization routine iterates until the target parameters are satisfied by applying the subplex optimization method. The resulting control signal in the small wave tank is then transferred to a large wave tank considering the electrical and hydrodynamic RAOs of the respective wave generator. The extreme sea state with the embedded New Year Wave obtained with this method is measured at different locations in the tank, in a range from 2163 m (full scale) ahead of to 1470 m behind the target position-520 registrations altogether. The focus lies on the detailed description of a possible evolution of the New Year Wave over a large area and time interval. The analysis of the registrations reveals freak waves occurring at three different positions in the wave tank and the observed freak waves are developing from a wave group of three waves, which travels with constant speed along the wave tank up to the target position. The group velocity, wave propagation, and the energy flux of this wave group are analyzed within this paper.

A Summary of Research on Energy Saving and Emission Reduction of Transportation

NASA Astrophysics Data System (ADS)

Cheng, Dongxiang; Wu, Lufen

2017-12-01

Road transport is an important part of transportation, and road in the field of energy-saving emission reduction is a very important industry. According to the existing problems of road energy saving and emission reduction, this paper elaborates the domestic and international research on energy saving and emission reduction from three aspects: road network optimization, pavement material and pavement maintenance. Road network optimization may be overlooked, and the research content is still relatively preliminary; pavement materials mainly from the asphalt pavement temperature mixed asphalt technology research; pavement maintenance technology development is relatively comprehensive.

Trials, tribulations, and triumphs of a pilot initiative to optimize the management of wounds complicated by diabetes within the home.

PubMed

Hodgins, Marilyn J; Logan, Susan M; Price, Karla; Thompson, Carol

2014-01-01

To support home health care nurses in their efforts to optimize the management of patients with wounds complicated by diabetes, an initiative was introduced that incorporated a standardized assessment tool, electronic data entry, and the provision of written treatment recommendations with supporting rationale prepared by nurses with expertise in diabetes and wound care. A pilot study was conducted that provided preliminary evidence of the feasibility of this initiative as well as its potential effect on outcomes for patients, nurses, and the home care program.

Hormesis and the Salk Polio Vaccine

PubMed Central

Calabrese, Edward J.

2011-01-01

The production of the Salk vaccine polio virus by monkey kidney cells was generated using the synthetic tissue culture medium, Mixture 199. In this paper’s retrospective assessment of this process, it was discovered that Mixture 199 was modified by the addition of ethanol to optimize animal cell survival based on experimentation that revealed a hormetic-like biphasic response relationship. This hormesis-based optimization procedure was then applied to all uses of Mixture 199 and modifications of it, including its application to the Salk polio vaccine during preliminary testing and in its subsequent major societal treatment programs. PMID:22423232

Three-dimensional aerodynamic shape optimization of supersonic delta wings

NASA Technical Reports Server (NTRS)

Burgreen, Greg W.; Baysal, Oktay

1994-01-01

A recently developed three-dimensional aerodynamic shape optimization procedure AeSOP(sub 3D) is described. This procedure incorporates some of the most promising concepts from the area of computational aerodynamic analysis and design, specifically, discrete sensitivity analysis, a fully implicit 3D Computational Fluid Dynamics (CFD) methodology, and 3D Bezier-Bernstein surface parameterizations. The new procedure is demonstrated in the preliminary design of supersonic delta wings. Starting from a symmetric clipped delta wing geometry, a Mach 1.62 asymmetric delta wing and two Mach 1. 5 cranked delta wings were designed subject to various aerodynamic and geometric constraints.

Optimization process in helicopter design

NASA Technical Reports Server (NTRS)

Logan, A. H.; Banerjee, D.

1984-01-01

In optimizing a helicopter configuration, Hughes Helicopters uses a program called Computer Aided Sizing of Helicopters (CASH), written and updated over the past ten years, and used as an important part of the preliminary design process of the AH-64. First, measures of effectiveness must be supplied to define the mission characteristics of the helicopter to be designed. Then CASH allows the designer to rapidly and automatically develop the basic size of the helicopter (or other rotorcraft) for the given mission. This enables the designer and management to assess the various tradeoffs and to quickly determine the optimum configuration.

Optimization of shape control of a cantilever beam using dielectric elastomer actuators

NASA Astrophysics Data System (ADS)

Liu, Chong; Mao, Boyong; Huang, Gangting; Wu, Qichen; Xie, Shilin; Xu, Minglong

2018-05-01

Dielectric elastomer (DE) is a kind of smart soft material that has many advantages such as large deformation, fast response, lightweight and easy synthesis. These features make dielectric elastomer a suitable material for actuators. This article focuses on the shape control of a cantilever beam by using dielectric elastomer actuators. The shape control equation in finite element formulation of the cantilever beam partially covered with dielectric elastomer actuators is derived based on the constitutive equation of dielectric elastomer material by using Hamilton principle. The actuating forces produced by dielectric elastomer actuators depend on the number of layers, the position and the actuation voltage of dielectric elastomer actuators. First, effects of these factors on the shape control accuracy when one pair or multiple pairs of actuators are employed are simulated, respectively. The simulation results demonstrate that increasing the number of actuators or the number of layers can improve the control effect and reduce the actuation voltages effectively. Second, to achieve the optimal shape control effect, the position of the actuators and the drive voltages are all determined using a genetic algorithm. The robustness of the genetic algorithm is analyzed. Moreover, the implications of using one pair and multiple pairs of actuators to drive the cantilever beam to the expected shape are investigated. The results demonstrate that a small number of actuators with optimal placement and optimal voltage values can achieve the shape control of the beam effectively. Finally, a preliminary experimental verification of the control effect is carried out, which shows the correctness of the theoretical method.

Process Integration and Optimization of ICME Carbon Fiber Composites for Vehicle Lightweighting: A Preliminary Development

DOE PAGES

Xu, Hongyi; Li, Yang; Zeng, Danielle

2017-01-02

Process integration and optimization is the key enabler of the Integrated Computational Materials Engineering (ICME) of carbon fiber composites. In this paper, automated workflows are developed for two types of composites: Sheet Molding Compounds (SMC) short fiber composites, and multi-layer unidirectional (UD) composites. For SMC, the proposed workflow integrates material processing simulation, microstructure representation volume element (RVE) models, material property prediction and structure preformation simulation to enable multiscale, multidisciplinary analysis and design. Processing parameters, microstructure parameters and vehicle subframe geometry parameters are defined as the design variables; the stiffness and weight of the structure are defined as the responses. Formore » multi-layer UD structure, this work focuses on the discussion of different design representation methods and their impacts on the optimization performance. Challenges in ICME process integration and optimization are also summarized and highlighted. Two case studies are conducted to demonstrate the integrated process and its application in optimization.« less

Optimization of OT-MACH Filter Generation for Target Recognition

NASA Technical Reports Server (NTRS)

Johnson, Oliver C.; Edens, Weston; Lu, Thomas T.; Chao, Tien-Hsin

2009-01-01

An automatic Optimum Trade-off Maximum Average Correlation Height (OT-MACH) filter generator for use in a gray-scale optical correlator (GOC) has been developed for improved target detection at JPL. While the OT-MACH filter has been shown to be an optimal filter for target detection, actually solving for the optimum is too computationally intensive for multiple targets. Instead, an adaptive step gradient descent method was tested to iteratively optimize the three OT-MACH parameters, alpha, beta, and gamma. The feedback for the gradient descent method was a composite of the performance measures, correlation peak height and peak to side lobe ratio. The automated method generated and tested multiple filters in order to approach the optimal filter quicker and more reliably than the current manual method. Initial usage and testing has shown preliminary success at finding an approximation of the optimal filter, in terms of alpha, beta, gamma values. This corresponded to a substantial improvement in detection performance where the true positive rate increased for the same average false positives per image.

Multi-objective optimization of an arch dam shape under static loads using an evolutionary game method

NASA Astrophysics Data System (ADS)

Meng, Rui; Cheong, Kang Hao; Bao, Wei; Wong, Kelvin Kian Loong; Wang, Lu; Xie, Neng-gang

2018-06-01

This article attempts to evaluate the safety and economic performance of an arch dam under the action of static loads. The geometric description of a crown cantilever section and the horizontal arch ring is presented. A three-objective optimization model of arch dam shape is established based on the arch dam volume, maximum principal tensile stress and total strain energy. The evolutionary game method is then applied to obtain the optimal solution. In the evolutionary game technique, a novel and more efficient exploration method of the game players' strategy space, named the 'sorting partition method under the threshold limit', is presented, with the game profit functions constructed according to both competitive and cooperative behaviour. By way of example, three optimization goals have all shown improvements over the initial solutions. In particular, the evolutionary game method has potentially faster convergence. This demonstrates the preliminary proof of principle of the evolutionary game method.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The objective of the contract is to consolidate the advances made during the previous contract in the conversion of syngas to motor fuels using Molecular Sieve-containing catalysts and to demonstrate the practical utility and economic value of the new catalyst/process systems with appropriate laboratory runs. Work on the program is divided into the following six tasks: (1) preparation of a detailed work plan covering the entire performance of the contract; (2) preliminary techno-economic assessment of the UCC catalyst/process system; (3) optimization of the most promising catalysts developed under prior contract; (4) optimization of the UCC catalyst system in a mannermore » that will give it the longest possible service life; (5) optimization of a UCC process/catalyst system based upon a tubular reactor with a recycle loop; and (6) economic evaluation of the optimal performance found under Task 5 for the UCC process/catalyst system. Accomplishments are reported for Tasks 2 through 5.« less

Optimally combining dynamical decoupling and quantum error correction.

PubMed

Paz-Silva, Gerardo A; Lidar, D A

2013-01-01

Quantum control and fault-tolerant quantum computing (FTQC) are two of the cornerstones on which the hope of realizing a large-scale quantum computer is pinned, yet only preliminary steps have been taken towards formalizing the interplay between them. Here we explore this interplay using the powerful strategy of dynamical decoupling (DD), and show how it can be seamlessly and optimally integrated with FTQC. To this end we show how to find the optimal decoupling generator set (DGS) for various subspaces relevant to FTQC, and how to simultaneously decouple them. We focus on stabilizer codes, which represent the largest contribution to the size of the DGS, showing that the intuitive choice comprising the stabilizers and logical operators of the code is in fact optimal, i.e., minimizes a natural cost function associated with the length of DD sequences. Our work brings hybrid DD-FTQC schemes, and their potentially considerable advantages, closer to realization.

Optimally combining dynamical decoupling and quantum error correction

PubMed Central

Paz-Silva, Gerardo A.; Lidar, D. A.

2013-01-01

Quantum control and fault-tolerant quantum computing (FTQC) are two of the cornerstones on which the hope of realizing a large-scale quantum computer is pinned, yet only preliminary steps have been taken towards formalizing the interplay between them. Here we explore this interplay using the powerful strategy of dynamical decoupling (DD), and show how it can be seamlessly and optimally integrated with FTQC. To this end we show how to find the optimal decoupling generator set (DGS) for various subspaces relevant to FTQC, and how to simultaneously decouple them. We focus on stabilizer codes, which represent the largest contribution to the size of the DGS, showing that the intuitive choice comprising the stabilizers and logical operators of the code is in fact optimal, i.e., minimizes a natural cost function associated with the length of DD sequences. Our work brings hybrid DD-FTQC schemes, and their potentially considerable advantages, closer to realization. PMID:23559088

Polarisation Measurement with a Dual Beam Interferometer (CATSI). Exploratory Results and Preliminary Phenomenological Analysis

DTIC Science & Technology

2006-06-01

Polarisation measurement with a dual beam interferometer (CATSI) Exploratory results and preliminary phenomenological analysis H. Lavoie J.-M... Polarisation measurement with a dual beam interferometer (CATSI) Exploratory results and preliminary phenomenological analysis H. Lavoie J.-M. Thériault... Polarisation measurement with a dual beam interferometer (CATSI) - Exploratory results and preliminary phenomenological analysis. ECR 2004-372. DRDC Valcartier

New human-centered linear and nonlinear motion cueing algorithms for control of simulator motion systems

NASA Astrophysics Data System (ADS)

Telban, Robert J.

While the performance of flight simulator motion system hardware has advanced substantially, the development of the motion cueing algorithm, the software that transforms simulated aircraft dynamics into realizable motion commands, has not kept pace. To address this, new human-centered motion cueing algorithms were developed. A revised "optimal algorithm" uses time-invariant filters developed by optimal control, incorporating human vestibular system models. The "nonlinear algorithm" is a novel approach that is also formulated by optimal control, but can also be updated in real time. It incorporates a new integrated visual-vestibular perception model that includes both visual and vestibular sensation and the interaction between the stimuli. A time-varying control law requires the matrix Riccati equation to be solved in real time by a neurocomputing approach. Preliminary pilot testing resulted in the optimal algorithm incorporating a new otolith model, producing improved motion cues. The nonlinear algorithm vertical mode produced a motion cue with a time-varying washout, sustaining small cues for longer durations and washing out large cues more quickly compared to the optimal algorithm. The inclusion of the integrated perception model improved the responses to longitudinal and lateral cues. False cues observed with the NASA adaptive algorithm were absent. As a result of unsatisfactory sensation, an augmented turbulence cue was added to the vertical mode for both the optimal and nonlinear algorithms. The relative effectiveness of the algorithms, in simulating aircraft maneuvers, was assessed with an eleven-subject piloted performance test conducted on the NASA Langley Visual Motion Simulator (VMS). Two methods, the quasi-objective NASA Task Load Index (TLX), and power spectral density analysis of pilot control, were used to assess pilot workload. TLX analysis reveals, in most cases, less workload and variation among pilots with the nonlinear algorithm. Control input analysis shows pilot-induced oscillations on a straight-in approach are less prevalent compared to the optimal algorithm. The augmented turbulence cues increased workload on an offset approach that the pilots deemed more realistic compared to the NASA adaptive algorithm. The takeoff with engine failure showed the least roll activity for the nonlinear algorithm, with the least rudder pedal activity for the optimal algorithm.

Motion Cueing Algorithm Development: Human-Centered Linear and Nonlinear Approaches

NASA Technical Reports Server (NTRS)

Houck, Jacob A. (Technical Monitor); Telban, Robert J.; Cardullo, Frank M.

2005-01-01

While the performance of flight simulator motion system hardware has advanced substantially, the development of the motion cueing algorithm, the software that transforms simulated aircraft dynamics into realizable motion commands, has not kept pace. Prior research identified viable features from two algorithms: the nonlinear "adaptive algorithm", and the "optimal algorithm" that incorporates human vestibular models. A novel approach to motion cueing, the "nonlinear algorithm" is introduced that combines features from both approaches. This algorithm is formulated by optimal control, and incorporates a new integrated perception model that includes both visual and vestibular sensation and the interaction between the stimuli. Using a time-varying control law, the matrix Riccati equation is updated in real time by a neurocomputing approach. Preliminary pilot testing resulted in the optimal algorithm incorporating a new otolith model, producing improved motion cues. The nonlinear algorithm vertical mode produced a motion cue with a time-varying washout, sustaining small cues for longer durations and washing out large cues more quickly compared to the optimal algorithm. The inclusion of the integrated perception model improved the responses to longitudinal and lateral cues. False cues observed with the NASA adaptive algorithm were absent. The neurocomputing approach was crucial in that the number of presentations of an input vector could be reduced to meet the real time requirement without degrading the quality of the motion cues.

Fusing Panchromatic and SWIR Bands Based on Cnn - a Preliminary Study Over WORLDVIEW-3 Datasets

NASA Astrophysics Data System (ADS)

Guo, M.; Ma, H.; Bao, Y.; Wang, L.

2018-04-01

The traditional fusion methods are based on the fact that the spectral ranges of the Panchromatic (PAN) and multispectral bands (MS) are almost overlapping. In this paper, we propose a new pan-sharpening method for the fusion of PAN and SWIR (short-wave infrared) bands, whose spectral coverages are not overlapping. This problem is addressed with a convolutional neural network (CNN), which is trained by WorldView-3 dataset. CNN can learn the complex relationship among bands, and thus alleviate spectral distortion. Consequently, in our network, we use the simple three-layer basic architecture with 16 × 16 kernels to conduct the experiment. Every layer use different receptive field. The first two layers compute 512 feature maps by using the 16 × 16 and 1 × 1 receptive field respectively and the third layer with a 8 × 8 receptive field. The fusion results are optimized by continuous training. As for assessment, four evaluation indexes including Entropy, CC, SAM and UIQI are selected built on subjective visual effect and quantitative evaluation. The preliminary experimental results demonstrate that the fusion algorithms can effectively enhance the spatial information. Unfortunately, the fusion image has spectral distortion, it cannot maintain the spectral information of the SWIR image.

Sewage sludge drying by energy recovery from OFMSW composting: preliminary feasibility evaluation.

PubMed

Rada, Elena Cristina; Ragazzi, Marco; Villotti, Stefano; Torretta, Vincenzo

2014-05-01

In this paper an original energy recovery method from composting is analyzed. The integrated system exploits the heat available from the aerobic biochemical process in order to support the drying of sewage sludge, using a specific solar greenhouse. The aim is to tackle the problem of organic waste treatment, with specific regard to food waste. This is done by optimizing the energy consumption of the aerobic process of composting, using the heat produced to solve a second important waste management problem such as the sewage waste treatment. Energy and mass balances are presented in a preliminary feasibility study. Referring to a composting plant with a capacity of 15,000 t/y of food waste, the estimation of the power from recovered heat for the entire plant resulted about 42 kW. The results demonstrated that the energy recoverable can cover part of the heat necessary for the treatment of sludge generated by the population served by the composting plant (in terms of food waste and green waste collection). The addition of a renewable source such as solar energy could cover the residual energy demand. The approach is presented in detail in order for it to be replicated in other case studies or at full scale applications. Copyright © 2014 Elsevier Ltd. All rights reserved.

Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project

PubMed Central

Benammar Elgaaied, Amel; Cascio, Donato; Bruno, Salvatore; Ciaccio, Maria Cristina; Cipolla, Marco; Fauci, Alessandro; Morgante, Rossella; Taormina, Vincenzo; Gorgi, Yousr; Marrakchi Triki, Raja; Ben Ahmed, Melika; Louzir, Hechmi; Yalaoui, Sadok; Imene, Sfar; Issaoui, Yassine; Abidi, Ahmed; Ammar, Myriam; Bedhiafi, Walid; Ben Fraj, Oussama; Bouhaha, Rym; Hamdi, Khouloud; Soumaya, Koudhi; Neili, Bilel; Asma, Gati; Lucchese, Mariano; Catanzaro, Maria; Barbara, Vincenza; Brusca, Ignazio; Fregapane, Maria; Amato, Gaetano; Friscia, Giuseppe; Neila, Trai; Turkia, Souayeh; Youssra, Haouami; Rekik, Raja; Bouokez, Hayet; Vasile Simone, Maria; Fauci, Francesco; Raso, Giuseppe

2016-01-01

Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This paper introduces the AIDA Project (autoimmunity: diagnosis assisted by computer) developed in the framework of an Italy-Tunisia cross-border cooperation and its preliminary results. A database of interpreted IIF images is being collected through the exchange of images and double reporting and a Gold Standard database, containing around 1000 double reported images, has been settled. The Gold Standard database is used for optimization of a CAD (Computer Aided Detection) solution and for the assessment of its added value, in order to be applied along with an Immunologist as a second Reader in detection of autoantibodies. This CAD system is able to identify on IIF images the fluorescence intensity and the fluorescence pattern. Preliminary results show that CAD, used as second Reader, appeared to perform better than Junior Immunologists and hence may significantly improve their efficacy; compared with two Junior Immunologists, the CAD system showed higher Intensity Accuracy (85,5% versus 66,0% and 66,0%), higher Patterns Accuracy (79,3% versus 48,0% and 66,2%), and higher Mean Class Accuracy (79,4% versus 56,7% and 64.2%). PMID:27042658

Influence of inter-stimulus interval of spinal cord stimulation in patients with disorders of consciousness: A preliminary functional near-infrared spectroscopy study.

PubMed

Zhang, Yujin; Yang, Yi; Si, Juanning; Xia, Xiaoyu; He, Jianghong; Jiang, Tianzi

2018-01-01

Spinal cord stimulation (SCS) is a promising treatment for disorders of consciousness (DOC), but the underlying mechanism and most effective procedures remain uncertain. To optimize the protocol, previous studies evaluated the frequency-specific effects of SCS on neurophysiological activities. However, whether and how the inter-stimulus interval (ISI) parameter affects the SCS neuromodulation in DOC remains unknown. We enrolled nine DOC patients who had implanted SCS devices and conducted three different durations of ISIs. Using functional near-infrared spectroscopy (fNIRS), we monitored the blood volume fluctuations in the prefrontal and occipital cortices during the SCS. The results showed that short stimuli (30 s) induced significant cerebral blood volume changes, especially in the prefrontal cortex, an important area in the consciousness system. By comparing the mean value of the responses from the first and the last block in each session, a shorter ISI was found to improve the blood volume in the prefrontal cortex. This phenomenon was more significant for the subgroup of patients with a favorable prognosis. These preliminary results imply that the ISI may be an important factor for SCS. The research paradigm proposed here also provides insights for further quantitative evaluations of the therapeutic effects of neuromodulation.

Vegetation change detection and quantification: linking Landsat imagery and LIDAR data

USGS Publications Warehouse

Peterson, Birgit E.; Nelson, Kurtis J.

2009-01-01

Measurements of the horizontal and vertical structure of vegetation are helpful for detecting and monitoring change or disturbance on the landscape. Lidar has a unique ability to capture the three-dimensional structure of vegetation canopies. In this preliminary study, we present the results of a series of exploratory data analyses that tested our assumptions about the links between the structural data obtainable from lidar and the change detection products derived from Landsat imagery. Our study area is located in the Sierra National Forest in the Sierra Nevada Mountains of California and covers a wide range of vegetation types. The lidar data used in this study were collected by the Laser Vegetation Imaging System (LVIS) (Blair et al., 1999). LVIS is a largefootprint lidar system optimized to measure canopy structure characteristics. A series of Landsat scenes from 1984 through 2008 was collected for the study area (Path 42, Row 34) and processed to generate maps of disturbance. The preliminary results described here indicate that even simple metrics of height can be useful in assessing changes in structure brought about by disturbance in forest canopies. For example, canopy height values for 2008 were higher on average than those measured for 1999 in undisturbed forest, whereas this trend is not clearly observable for the disturbed forest patches.

SU-D-12A-06: A Comprehensive Parameter Analysis for Low Dose Cone-Beam CT Reconstruction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, W; Southern Medical University, Guangzhou; Yan, H

Purpose: There is always a parameter in compressive sensing based iterative reconstruction (IR) methods low dose cone-beam CT (CBCT), which controls the weight of regularization relative to data fidelity. A clear understanding of the relationship between image quality and parameter values is important. The purpose of this study is to investigate this subject based on experimental data and a representative advanced IR algorithm using Tight-frame (TF) regularization. Methods: Three data sets of a Catphan phantom acquired at low, regular and high dose levels are used. For each tests, 90 projections covering a 200-degree scan range are used for reconstruction. Threemore » different regions-of-interest (ROIs) of different contrasts are used to calculate contrast-to-noise ratios (CNR) for contrast evaluation. A single point structure is used to measure modulation transfer function (MTF) for spatial-resolution evaluation. Finally, we analyze CNRs and MTFs to study the relationship between image quality and parameter selections. Results: It was found that: 1) there is no universal optimal parameter. The optimal parameter value depends on specific task and dose level. 2) There is a clear trade-off between CNR and resolution. The parameter for the best CNR is always smaller than that for the best resolution. 3) Optimal parameters are also dose-specific. Data acquired under a high dose protocol require less regularization, yielding smaller optimal parameter values. 4) Comparing with conventional FDK images, TF-based CBCT images are better under a certain optimally selected parameters. The advantages are more obvious for low dose data. Conclusion: We have investigated the relationship between image quality and parameter values in the TF-based IR algorithm. Preliminary results indicate optimal parameters are specific to both the task types and dose levels, providing guidance for selecting parameters in advanced IR algorithms. This work is supported in part by NIH (1R01CA154747-01)« less

Adaptive bi-level programming for optimal gene knockouts for targeted overproduction under phenotypic constraints

PubMed Central

2013-01-01

Background Optimization procedures to identify gene knockouts for targeted biochemical overproduction have been widely in use in modern metabolic engineering. Flux balance analysis (FBA) framework has provided conceptual simplifications for genome-scale dynamic analysis at steady states. Based on FBA, many current optimization methods for targeted bio-productions have been developed under the maximum cell growth assumption. The optimization problem to derive gene knockout strategies recently has been formulated as a bi-level programming problem in OptKnock for maximum targeted bio-productions with maximum growth rates. However, it has been shown that knockout mutants in fact reach the steady states with the minimization of metabolic adjustment (MOMA) from the corresponding wild-type strains instead of having maximal growth rates after genetic or metabolic intervention. In this work, we propose a new bi-level computational framework--MOMAKnock--which can derive robust knockout strategies under the MOMA flux distribution approximation. Methods In this new bi-level optimization framework, we aim to maximize the production of targeted chemicals by identifying candidate knockout genes or reactions under phenotypic constraints approximated by the MOMA assumption. Hence, the targeted chemical production is the primary objective of MOMAKnock while the MOMA assumption is formulated as the inner problem of constraining the knockout metabolic flux to be as close as possible to the steady-state phenotypes of wide-type strains. As this new inner problem becomes a quadratic programming problem, a novel adaptive piecewise linearization algorithm is developed in this paper to obtain the exact optimal solution to this new bi-level integer quadratic programming problem for MOMAKnock. Results Our new MOMAKnock model and the adaptive piecewise linearization solution algorithm are tested with a small E. coli core metabolic network and a large-scale iAF1260 E. coli metabolic network. The derived knockout strategies are compared with those from OptKnock. Our preliminary experimental results show that MOMAKnock can provide improved targeted productions with more robust knockout strategies. PMID:23368729

Improving rotorcraft survivability to RPG attack using inverse methods

NASA Astrophysics Data System (ADS)

Anderson, D.; Thomson, D. G.

2009-09-01

This paper presents the results of a preliminary investigation of optimal threat evasion strategies for improving the survivability of rotorcraft under attack by rocket propelled grenades (RPGs). The basis of this approach is the application of inverse simulation techniques pioneered for simulation of aggressive helicopter manoeuvres to the RPG engagement problem. In this research, improvements in survivability are achieved by computing effective evasive manoeuvres. The first step in this process uses the missile approach warning system camera (MAWS) on the aircraft to provide angular information of the threat. Estimates of the RPG trajectory and impact point are then estimated. For the current flight state an appropriate evasion response is selected then realised via inverse simulation of the platform dynamics. Results are presented for several representative engagements showing the efficacy of the approach.

Ablative thermal management structural material on the hypersonic vehicles

NASA Astrophysics Data System (ADS)

Shortland, H.; Tsai, C.

A hypersonic vehicle is designed to fly at high Mach number in the earth's atmosphere that will result in higher aerodynamic heating loads on specific areas of the vehicle. A thermal protection system is required for these areas that may exceed the operating temperature limit of structural materials. This paper delineates the application of ablative material as the passive type of thermal protection system for the nose or wing leading edges. A simplified quasi-steady-state one-dimensional computer model was developed to evaluate the performance and thermal design of a leading edge. The detailed description of the governing mathematical equations and results are presented. This model provides a quantitative information to support the design estimate, performance optimization, and assess preliminary feasibility of using ablation as a design approach.

Application of optimal control principles to describe the supervisory control behavior of AAA crew members

NASA Technical Reports Server (NTRS)

Hale, C.; Valentino, G. J.

1982-01-01

Supervisory decision making and control behavior within a C(3) oriented, ground based weapon system is being studied. The program involves empirical investigation of the sequence of control strategies used during engagement of aircraft targets. An engagement is conceptually divided into several stages which include initial information processing activity, tracking, and ongoing adaptive control decisions. Following a brief description of model parameters, two experiments which served as initial investigation into the accuracy of assumptions regarding the importance of situation assessment in procedure selection are outlined. Preliminary analysis of the results upheld the validity of the assumptions regarding strategic information processing and cue-criterion relationship learning. These results indicate that this model structure should be useful in studies of supervisory decision behavior.

Advanced electric propulsion research, 1989

NASA Technical Reports Server (NTRS)

Wilbur, Paul J.

1990-01-01

Results of an experimental study of the characteristics of ion thruster hollow cathodes operating at high discharge currents (up to 60 A) are presented in a companion report. This work shows that ions produced near the cathode orifice can acquire sufficient energy to induce the high sputter erosion rates on cathode potential surfaces that have been observed in ion thrusters. A mechanism by which these ions could be produced is also described. A second, brief study showing how a discharge chamber model developed previously can be applied to determine optimal values for one or more discharge chamber design parameters is presented. The experimental approach being used to study the plasma potential field and charge-exchange ion production rate downstream of the accelerator grid of an ion thruster is discussed and preliminary results are presented.

The Problem of Size in Robust Design

NASA Technical Reports Server (NTRS)

Koch, Patrick N.; Allen, Janet K.; Mistree, Farrokh; Mavris, Dimitri

1997-01-01

To facilitate the effective solution of multidisciplinary, multiobjective complex design problems, a departure from the traditional parametric design analysis and single objective optimization approaches is necessary in the preliminary stages of design. A necessary tradeoff becomes one of efficiency vs. accuracy as approximate models are sought to allow fast analysis and effective exploration of a preliminary design space. In this paper we apply a general robust design approach for efficient and comprehensive preliminary design to a large complex system: a high speed civil transport (HSCT) aircraft. Specifically, we investigate the HSCT wing configuration design, incorporating life cycle economic uncertainties to identify economically robust solutions. The approach is built on the foundation of statistical experimentation and modeling techniques and robust design principles, and is specialized through incorporation of the compromise Decision Support Problem for multiobjective design. For large problems however, as in the HSCT example, this robust design approach developed for efficient and comprehensive design breaks down with the problem of size - combinatorial explosion in experimentation and model building with number of variables -and both efficiency and accuracy are sacrificed. Our focus in this paper is on identifying and discussing the implications and open issues associated with the problem of size for the preliminary design of large complex systems.

75 FR 19610 - Solid Urea From the Russian Federation: Preliminary Results of Antidumping Duty Administrative...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-15

... Federation: Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration.... We invite interested parties to comment on these preliminary results. Parties who submit argument in...

Wind turbine blades: A study of prototypes in a steady regime - Unsteady considerations

NASA Astrophysics Data System (ADS)

Leblanc, R.; Goethals, R.; de Saint Louvent, B.

1981-11-01

The results of comparisons of numerical models with experimental results for the performance of prototype wind turbines in steady flows are presented, along with preliminary results on behavior in unsteady flows. The numerical models are based on previous schemes devised for propellers, with modifications for small perturbations, significant radial velocity effects from the wake, and the fact that the speed is induced. Two computational methods are currently used, one a method of short blades, the other the Prandtl lifting line theory. Trials have been run in the T4 wind tunnel using a 3 m horizontal axis machine and a 2.5 m Darrieus. Attention is given to modeling the structural dynamics and turbulent flow structures encountered by wind turbines. Experimental results relating windspeed, angle of attack, and output are presented. Optimization studies have indicated that wind farms will require a 6-7 blade diameter unit spacing to maintain satisfactory group output efficiencies.

Assessment of molecular contamination in mask pod

NASA Astrophysics Data System (ADS)

Foray, Jean Marie; Dejaune, Patrice; Sergent, Pierre; Gough, Stuart; Cheung, D.; Davenet, Magali; Favre, Arnaud; Rude, C.; Trautmann, T.; Tissier, Michel; Fontaine, H.; Veillerot, M.; Avary, K.; Hollein, I.; Lerit, R.

2008-04-01

Context/ study Motivation: Contamination and especially Airbone Molecular Contamination (AMC) is a critical issue for mask material flow with a severe and fairly unpredictable risk of induced contamination and damages especially for 193 nm lithography. It is therefore essential to measure, to understand and then try to reduce AMC in mask environment. Mask material flow was studied in a global approach by a pool of European partners, especially within the frame of European MEDEA+ project, so called "MUSCLE". This paper deals with results and assessment of mask pod environment in term of molecular contamination in a first step, then in a second step preliminary studies to reduce mask pod influence and contamination due to material out gassing. Approach and techniques: A specific assessment of environmental / molecular contamination along the supply chain was performed by all partners. After previous work presented at EMLC 07, further studies were performed on real time contamination measurement pod at different sites locations (including Mask manufacturing site, blank manufacturing sites, IC fab). Studies were linked to the main critical issues: cleaning, storage, handling, materials and processes. Contamination measurement campaigns were carried out along the mask supply chain using specific Adixen analyzer in order to monitor in real time organic contaminants (ppb level) in mask pods. Key results would be presented: VOC, AMC and humidity level on different kinds of mask carriers, impact of basic cleaning on pod outgassing measurement (VOC, NH3), and process influence on pod contamination... In a second step, preliminary specific pod conditioning studies for better pod environment were performed based on Adixen vacuum process. Process influence had been experimentally measured in term of molecular outgassing from mask pods. Different AMC experimental characterization methods had been carried out leading to results on a wide range of organic and inorganic contaminants: by inline techniques based on Adixen humidity, also VOC and organic sensors, together by off-line techniques already used in the extensive previous mask pods benchmark (TD-GCMS & Ionic Chromatography). Humidity and VOC levels from mask carriers had shown significant reduction after Adixen pod conditioning process. Focus had been made on optimized vacuum step (for AMC) after particles carrier cleaning cycle. Based upon these key results new procedures, as well as guidelines for mask carrier cleaning optimization are proposed to improve pod contamination control. Summary results/next steps: This paper reports molecular contamination measurement campaigns performed by a pool of European partners along the mask supply chain. It allows us to investigate, identify and quantify critical molecular contamination in mask pod, as well as VOC and humidity, issues depending on locations, uses, and carrier's type. Preliminary studies highlight initial process solutions for pods conditioning that are being used for short term industrialization and further industrialized.

An Analysis of Excellent Early Educational Practices: Preliminary Report.

ERIC Educational Resources Information Center

White, Burton L.

This document reports the first phase of a longitudinal research project designed to produce information on how to raise children so their basic abilities may develop optimally during the first six years of life. Although this Preschool Project has been in operation five years, the study is not yet completed because statements about the effects of…

75 FR 47307 - Center for Devices and Radiological Health 510(k) Working Group Preliminary Report and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-05

... 510(k) program optimally achieves these goals. In September 2009, CDRH convened an internal 510(k...) program and explore actions CDRH could take to strengthen the program and improve the consistency of its... CDRH uses science to guide its regulatory decision making across the total product life cycle of...

Discharge characteristics of 300 ampere-hour Ni-Zn traction cells

NASA Technical Reports Server (NTRS)

Ewashinka, J. G.

1979-01-01

Preliminary tests were performed on 300 amphere-hour nickel-zinc cells containing the Lewis improved inorganic-organic (I/O) separator. These cells also have other design features included to optimize performance and cycle life. The tests carried out were formation tests and characteristic discharge tests. Information obtained include case temperature and maximum power delivered.

Advanced Intelligent System Application to Load Forecasting and Control for Hybrid Electric Bus

NASA Technical Reports Server (NTRS)

Momoh, James; Chattopadhyay, Deb; Elfayoumy, Mahmoud

1996-01-01

The primary motivation for this research emanates from providing a decision support system to the electric bus operators in the municipal and urban localities which will guide the operators to maintain an optimal compromise among the noise level, pollution level, fuel usage etc. This study is backed up by our previous studies on study of battery characteristics, permanent magnet DC motor studies and electric traction motor size studies completed in the first year. The operator of the Hybrid Electric Car must determine optimal power management schedule to meet a given load demand for different weather and road conditions. The decision support system for the bus operator comprises three sub-tasks viz. forecast of the electrical load for the route to be traversed divided into specified time periods (few minutes); deriving an optimal 'plan' or 'preschedule' based on the load forecast for the entire time-horizon (i.e., for all time periods) ahead of time; and finally employing corrective control action to monitor and modify the optimal plan in real-time. A fully connected artificial neural network (ANN) model is developed for forecasting the kW requirement for hybrid electric bus based on inputs like climatic conditions, passenger load, road inclination, etc. The ANN model is trained using back-propagation algorithm employing improved optimization techniques like projected Lagrangian technique. The pre-scheduler is based on a Goal-Programming (GP) optimization model with noise, pollution and fuel usage as the three objectives. GP has the capability of analyzing the trade-off among the conflicting objectives and arriving at the optimal activity levels, e.g., throttle settings. The corrective control action or the third sub-task is formulated as an optimal control model with inputs from the real-time data base as well as the GP model to minimize the error (or deviation) from the optimal plan. These three activities linked with the ANN forecaster proving the output to the GP model which in turn produces the pre-schedule of the optimal control model. Some preliminary results based on a hypothetical test case will be presented for the load forecasting module. The computer codes for the three modules will be made available fe adoption by bus operating agencies. Sample results will be provided using these models. The software will be a useful tool for supporting the control systems for the Electric Bus project of NASA.

An Approach to Designing Passive Self-Leveling Landing Gear with Application to the Lunar Lander

NASA Technical Reports Server (NTRS)

Rippere, Troy B.; Wiens, Gloria J.

2010-01-01

Once the lunar lander has touched down on the moon problems can occur if the crew module is not level. To mitigate, compliant landing gear provide a solution that would allow the module to be leveled once it has landed on some ground slope. The work presented here uses compliant joints, or flexures, for each leg of the module and optimizes the mechanics of these flexures such that the module can be passively leveled over a range of landing slopes. Preliminary results suggest that for landing on a slope of up to 12 deg the effective slope of the module can be reduced to a maximum of 2.5 deg.

Engineering development studies for integrated evacuated CPC arrays

NASA Astrophysics Data System (ADS)

Winston, R.

1982-04-01

An evacuated tube concentrator which achieves respectable high temperature performance (100 C to 300 C) was developed. The design concept utilizes nonimaging CPC type concentration integrated into each tube by shaping the outer glass vacuum envelope. The detailed design, prototype fabrication and preliminary test measurements are reviewed. In addition the results of this first study specifically devoted to engineering development questions related to practical applications of this collector concept are summarized. Questions having to do with the deployment of medium to large area arrays, optimizations of the manifolding of individual tube panels, selected near term applications (with an emphasis on residential cooling based on Rankine driven chillers) and long term performance projections are addressed.

Development of the 7.3 MW MOD-5A wind-turbine generator system

NASA Astrophysics Data System (ADS)

Barton, R. S.; Lucas, W. C.

1983-12-01

The General Electric Company Advanced Energy Programs Department is designing, under DOE/NASA sponsorship through Contract DEN 3-153, the MOD-5A wind-turbine system, which must generate electricity for less than 3.75 cents/kWh (1980 dollars). During the conceptual and preliminary design phases, the basic features were established as a result of tradeoff and optimization studies driven by minimizing the system cost of energy. During the past year, the program has been in the final design phase, and a reassessment to minimize risk has received strong emphasis in the design process. The program has progressed to the point that an agreement of sale has been reached for the first unit.

E-Pad: a comfortable electrocutaneous-based tactile feedback display

NASA Astrophysics Data System (ADS)

Wang, Jiabin; Zhao, Lu; Liu, Yue; Wang, Yongtian; Cai, Yi

2018-01-01

The devices with touchscreen are becoming more popular recently; however, most of them suffer from the crucial drawbacks of lacking accurate tactile feedback. A novel electrocutaneous-based tactile device with the name of E-pad is proposed to provide a dynamic and static low-voltage feedback for touchscreen. We optimize the key parameters of the output voltage and design custom-made hardwares to guarantee a comfortable user experience. Users could move their fingers freely across the touchscreen of the proposed device to really feel virtual objects. Two preliminary experiments are conducted to evaluate the interactive performance of the proposed device and the experimental results show that the proposed device can provide a comfortable and distinct tactile feedback.

Preliminary design procedure for insulated structures subjected to transient heating

NASA Technical Reports Server (NTRS)

Adelman, H. M.

1979-01-01

Minimum-mass designs were obtained for insulated structural panels loaded by a general set of inplane forces and a time dependent temperature. Temperature and stress histories in the structure are given by closed-form solutions, and optimization of the insulation and structural thicknesses is performed by nonlinear mathematical programming techniques. Design calculations are described to evaluate the structural efficiency of eight materials under combined heating and mechanical loads: graphite/polyimide, graphite/epoxy, boron/aluminum, titanium, aluminum, Rene 41, carbon/carbon, and Lockalloy. The effect on design mass of intensity and duration of heating were assessed. Results indicate that an optimum structure may have a temperature response well below the recommended allowable temperature for the material.

Improved lifetime high voltage switch electrode

NASA Astrophysics Data System (ADS)

Halverson, W.

1985-06-01

In this Phase 1 Small Business Innovation Research (SBIR) program, preliminary tests of ion implantation to increase the lifetime of spark switch electrodes have indicated that a 185 keV carbon ion implant into a tungsten-copper composite has reduced electrode erosion by a factor of two to four. Apparently, the thin layer of tungsten carbide (WC) has better thermal properties than pure tungsten; the WC may have penetrated into the unimplanted body of the electrode by liquid and/or solid phase diffusion during erosion testing. These encouraging results should provide the basis for a Phase 2 SBIR program to investigate further the physical and chemical effects of ion implantation on spark gap electrodes and to optimize the technique for applications.

Performance optimization of internet firewalls

NASA Astrophysics Data System (ADS)

Chiueh, Tzi-cker; Ballman, Allen

1997-01-01

Internet firewalls control the data traffic in and out of an enterprise network by checking network packets against a set of rules that embodies an organization's security policy. Because rule checking is computationally more expensive than routing-table look-up, it could become a potential bottleneck for scaling up the performance of IP routers, which typically implement firewall functions in software. in this paper, we analyzed the performance problems associated with firewalls, particularly packet filters, propose a good connection cache to amortize the costly security check over the packets in a connection, and report the preliminary performance results of a trace-driven simulation that show the average packet check time can be reduced by a factor of 2.5 at the least.

Preliminary study of tissue concentrations of penicillin after local administration into the guttural pouches in four healthy horses.

PubMed

Kendall, A; Mayhew, I G; Petrovski, K

2016-08-01

Treatment of subclinical carriers of Streptococcus equi subsp. equi with a gelatine-penicillin formulation deposited in the guttural pouch has been empirically proposed, but data on local tissue penicillin concentrations after treatment are lacking. We analysed tissue levels of penicillin after administration into the guttural pouches of four healthy horses. Two horses received local treatment with gelatine-penicillin and two horses received local treatment with an intramammary formulation of penicillin. Tissues were harvested for analysis either 12 or 24 h later. Results indicate that local treatment may be effective, but more research on optimal drug formulations in a larger sample size is warranted. © 2016 Australian Veterinary Association.

Electromagnetic Physics Models for Parallel Computing Architectures

NASA Astrophysics Data System (ADS)

Amadio, G.; Ananya, A.; Apostolakis, J.; Aurora, A.; Bandieramonte, M.; Bhattacharyya, A.; Bianchini, C.; Brun, R.; Canal, P.; Carminati, F.; Duhem, L.; Elvira, D.; Gheata, A.; Gheata, M.; Goulas, I.; Iope, R.; Jun, S. Y.; Lima, G.; Mohanty, A.; Nikitina, T.; Novak, M.; Pokorski, W.; Ribon, A.; Seghal, R.; Shadura, O.; Vallecorsa, S.; Wenzel, S.; Zhang, Y.

2016-10-01

The recent emergence of hardware architectures characterized by many-core or accelerated processors has opened new opportunities for concurrent programming models taking advantage of both SIMD and SIMT architectures. GeantV, a next generation detector simulation, has been designed to exploit both the vector capability of mainstream CPUs and multi-threading capabilities of coprocessors including NVidia GPUs and Intel Xeon Phi. The characteristics of these architectures are very different in terms of the vectorization depth and type of parallelization needed to achieve optimal performance. In this paper we describe implementation of electromagnetic physics models developed for parallel computing architectures as a part of the GeantV project. Results of preliminary performance evaluation and physics validation are presented as well.

Unsupervised machine-learning method for improving the performance of ambulatory fall-detection systems

PubMed Central

2012-01-01

Background Falls can cause trauma, disability and death among older people. Ambulatory accelerometer devices are currently capable of detecting falls in a controlled environment. However, research suggests that most current approaches can tend to have insufficient sensitivity and specificity in non-laboratory environments, in part because impacts can be experienced as part of ordinary daily living activities. Method We used a waist-worn wireless tri-axial accelerometer combined with digital signal processing, clustering and neural network classifiers. The method includes the application of Discrete Wavelet Transform, Regrouping Particle Swarm Optimization, Gaussian Distribution of Clustered Knowledge and an ensemble of classifiers including a multilayer perceptron and Augmented Radial Basis Function (ARBF) neural networks. Results Preliminary testing with 8 healthy individuals in a home environment yields 98.6% sensitivity to falls and 99.6% specificity for routine Activities of Daily Living (ADL) data. Single ARB and MLP classifiers were compared with a combined classifier. The combined classifier offers the greatest sensitivity, with a slight reduction in specificity for routine ADL and an increased specificity for exercise activities. In preliminary tests, the approach achieves 100% sensitivity on in-group falls, 97.65% on out-group falls, 99.33% specificity on routine ADL, and 96.59% specificity on exercise ADL. Conclusion The pre-processing and feature-extraction steps appear to simplify the signal while successfully extracting the essential features that are required to characterize a fall. The results suggest this combination of classifiers can perform better than MLP alone. Preliminary testing suggests these methods may be useful for researchers who are attempting to improve the performance of ambulatory fall-detection systems. PMID:22336100

Vibroacoustic optimization using a statistical energy analysis model

NASA Astrophysics Data System (ADS)

Culla, Antonio; D`Ambrogio, Walter; Fregolent, Annalisa; Milana, Silvia

2016-08-01

In this paper, an optimization technique for medium-high frequency dynamic problems based on Statistical Energy Analysis (SEA) method is presented. Using a SEA model, the subsystem energies are controlled by internal loss factors (ILF) and coupling loss factors (CLF), which in turn depend on the physical parameters of the subsystems. A preliminary sensitivity analysis of subsystem energy to CLF's is performed to select CLF's that are most effective on subsystem energies. Since the injected power depends not only on the external loads but on the physical parameters of the subsystems as well, it must be taken into account under certain conditions. This is accomplished in the optimization procedure, where approximate relationships between CLF's, injected power and physical parameters are derived. The approach is applied on a typical aeronautical structure: the cabin of a helicopter.

Optimization of levitation and guidance forces in a superconducting Maglev system

NASA Astrophysics Data System (ADS)

Yildizer, Irfan; Cansiz, Ahmet; Ozturk, Kemal

2016-09-01

Optimization of the levitation for superconducting Maglev systems requires effective use of vertical and guidance forces during the operation. In this respect the levitation and guidance forces in terms of various permanent magnet array configurations are analyzed. The arrangements of permanent magnet arrays interacting with the superconductor are configured for the purpose of increasing the magnetic flux density. According to configurations, modeling the interaction forces between the permanent magnet and the superconductor are established in terms of the frozen image model. The model is complemented with the analytical calculations and provides a reasonable agreement with the experiments. The agreement of the analytical calculation associated with the frozen image model indicates a strong case to establish an optimization, in which provides preliminary analysis before constructing more complex Maglev system.

Development of methodologies for the estimation of thermal properties associated with aerospace vehicles

NASA Technical Reports Server (NTRS)

Scott, Elaine P.

1993-01-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles such as the National Aero-Space Plane (NASP) and the High-Speed Civil Transport (HSCT) at NASA-LaRC. These analyses require knowledge of the temperature within the structures which consequently necessitates the need for thermal property data. The initial goal of this research effort was to develop a methodology for the estimation of thermal properties of aerospace structural materials at room temperature and to develop a procedure to optimize the estimation process. The estimation procedure was implemented utilizing a general purpose finite element code. In addition, an optimization procedure was developed and implemented to determine critical experimental parameters to optimize the estimation procedure. Finally, preliminary experiments were conducted at the Aircraft Structures Branch (ASB) laboratory.

Synthesis and Process Optimization of Electrospun PEEK-Sulfonated Nanofibers by Response Surface Methodology

PubMed Central

Boaretti, Carlo; Roso, Martina; Lorenzetti, Alessandra; Modesti, Michele

2015-01-01

In this study electrospun nanofibers of partially sulfonated polyether ether ketone have been produced as a preliminary step for a possible development of composite proton exchange membranes for fuel cells. Response surface methodology has been employed for the modelling and optimization of the electrospinning process, using a Box-Behnken design. The investigation, based on a second order polynomial model, has been focused on the analysis of the effect of both process (voltage, tip-to-collector distance, flow rate) and material (sulfonation degree) variables on the mean fiber diameter. The final model has been verified by a series of statistical tests on the residuals and validated by a comparison procedure of samples at different sulfonation degrees, realized according to optimized conditions, for the production of homogeneous thin nanofibers. PMID:28793427

Parallel Monotonic Basin Hopping for Low Thrust Trajectory Optimization

NASA Technical Reports Server (NTRS)

McCarty, Steven L.; McGuire, Melissa L.

2018-01-01

Monotonic Basin Hopping has been shown to be an effective method of solving low thrust trajectory optimization problems. This paper outlines an extension to the common serial implementation by parallelizing it over any number of available compute cores. The Parallel Monotonic Basin Hopping algorithm described herein is shown to be an effective way to more quickly locate feasible solutions, and improve locally optimal solutions in an automated way without requiring a feasible initial guess. The increased speed achieved through parallelization enables the algorithm to be applied to more complex problems that would otherwise be impractical for a serial implementation. Low thrust cislunar transfers and a hybrid Mars example case demonstrate the effectiveness of the algorithm. Finally, a preliminary scaling study quantifies the expected decrease in solve time compared to a serial implementation.,

Development of methodologies for the estimation of thermal properties associated with aerospace vehicles

NASA Astrophysics Data System (ADS)

Scott, Elaine P.

1993-12-01

Thermal stress analyses are an important aspect in the development of aerospace vehicles such as the National Aero-Space Plane (NASP) and the High-Speed Civil Transport (HSCT) at NASA-LaRC. These analyses require knowledge of the temperature within the structures which consequently necessitates the need for thermal property data. The initial goal of this research effort was to develop a methodology for the estimation of thermal properties of aerospace structural materials at room temperature and to develop a procedure to optimize the estimation process. The estimation procedure was implemented utilizing a general purpose finite element code. In addition, an optimization procedure was developed and implemented to determine critical experimental parameters to optimize the estimation procedure. Finally, preliminary experiments were conducted at the Aircraft Structures Branch (ASB) laboratory.

Synthesis and Process Optimization of Electrospun PEEK-Sulfonated Nanofibers by Response Surface Methodology.

PubMed

Boaretti, Carlo; Roso, Martina; Lorenzetti, Alessandra; Modesti, Michele

2015-07-07

In this study electrospun nanofibers of partially sulfonated polyether ether ketone have been produced as a preliminary step for a possible development of composite proton exchange membranes for fuel cells. Response surface methodology has been employed for the modelling and optimization of the electrospinning process, using a Box-Behnken design. The investigation, based on a second order polynomial model, has been focused on the analysis of the effect of both process (voltage, tip-to-collector distance, flow rate) and material (sulfonation degree) variables on the mean fiber diameter. The final model has been verified by a series of statistical tests on the residuals and validated by a comparison procedure of samples at different sulfonation degrees, realized according to optimized conditions, for the production of homogeneous thin nanofibers.

MRI-guided procedures in various regions of the body using a robotic assistance system in a closed-bore scanner: preliminary clinical experience and limitations.

PubMed

Moche, Michael; Zajonz, Dirk; Kahn, Thomas; Busse, Harald

2010-04-01

To present the clinical setup and workflow of a robotic assistance system for image-guided interventions in a conventional magnetic resonance imaging (MRI) environment and to report our preliminary clinical experience with percutaneous biopsies in various body regions. The MR-compatible, servo-pneumatically driven, robotic device (Innomotion) fits into the 60-cm bore of a standard MR scanner. The needle placement (n = 25) accuracy was estimated by measuring the 3D deviation between needle tip and prescribed target point in a phantom. Percutaneous biopsies in six patients and different body regions were planned by graphically selecting entry and target points on intraoperatively acquired roadmap MR data. For insertion depths between 29 and 95 mm, the average 3D needle deviation was 2.2 +/- 0.7 mm (range 0.9-3.8 mm). Patients with a body mass index of up to approximately 30 kg/m(2) fitted into the bore with the device. Clinical work steps and limitations are reported for the various applications. All biopsies were diagnostic and could be completed without any major complications. Median planning and intervention times were 25 (range 20-36) and 44 (36-68) minutes, respectively. Preliminary clinical results in a standard MRI environment suggest that the presented robotic device provides accurate guidance for percutaneous procedures in various body regions. Shorter procedure times may be achievable by optimizing technical and workflow aspects. (c) 2010 Wiley-Liss, Inc.