Sample records for opytnom proizvodstve tekhnologicheski

  1. Ways of Use of Ionizing Radiation in the Manufacture of Bacterial Preparations; PUTI ISPOL'ZOVANIYA IONIZIRUYUSHCHEI RADIATSII V PROIZVODSTVE BAKTERIINYKH PREPARATOV

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Troitskii, V.L.; Tumanyan, M.A. et al.

    1959-10-31

    Experiments are reported which give encouraging results for applications of ionizing radiations in the sterilization of vaccines, antitoxins, and serums for use in medical prophylaxis and treatment. A cobalt-60 gamma source was used. A dose of 1.5 Mr had a sterilizing effect, killing not only vegetative bacteria but sporeformers as well. Irradiation with sterilizing doses did not reduce the nutrient properties of meat media used for growth of bacteria of the intestinal group. The formation of diphtheria toxin proceeded on irradiated media the same as on nonirradiated. Irradiation did not reduce the antigenic or immunological properties of typhoid vaccines ormore » diphtheria and tetanus antitoxins. Serum products deteriorated after exposure to sterilizing doses but showed good tolerances to doses which killed vegetative forms of bacteria. It was concluded that ionizing radiation will prove practical for the preparation of many pharmaceutical products, the cold sterilization of nutrient broth, and the cold sterilization of the wastes from the manufacture of bacterial preparations. (C.H.)« less