Estimation of skin concentrations of topically applied lidocaine at each depth profile.

PubMed

Oshizaka, Takeshi; Kikuchi, Keisuke; Kadhum, Wesam R; Todo, Hiroaki; Hatanaka, Tomomi; Wierzba, Konstanty; Sugibayashi, Kenji

2014-11-20

Skin concentrations of topically administered compounds need to be considered in order to evaluate their efficacies and toxicities. This study investigated the relationship between the skin permeation and concentrations of compounds, and also predicted the skin concentrations of these compounds using their permeation parameters. Full-thickness skin or stripped skin from pig ears was set on a vertical-type diffusion cell, and lidocaine (LID) solution was applied to the stratum corneum (SC) in order to determine in vitro skin permeability. Permeation parameters were obtained based on Fick's second law of diffusion. LID concentrations at each depth of the SC were measured using tape-stripping. Concentration-depth profiles were obtained from viable epidermis and dermis (VED) by analyzing horizontal sections. The corresponding skin concentration at each depth was calculated based on Fick's law using permeation parameters and then compared with the observed value. The steady state LID concentrations decreased linearly as the site became deeper in SC or VED. The calculated concentration-depth profiles of the SC and VED were almost identical to the observed profiles. The compound concentration at each depth could be easily predicted in the skin using diffusion equations and skin permeation data. Thus, this method was considered to be useful for promoting the efficient preparation of topically applied drugs and cosmetics. Copyright © 2014 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Isa, Sharena Mohamad; Ali, Anati

In this paper, the hydromagnetic flow of dusty fluid over a vertical stretching sheet with thermal radiation is investigated. The governing partial differential equations are reduced to nonlinear ordinary differential equations using similarity transformation. These nonlinear ordinary differential equations are solved numerically using Runge-Kutta Fehlberg fourth-fifth order method (RKF45 Method). The behavior of velocity and temperature profiles of hydromagnetic fluid flow of dusty fluid is analyzed and discussed for different parameters of interest such as unsteady parameter, fluid-particle interaction parameter, the magnetic parameter, radiation parameter and Prandtl number on the flow.

Using spin-label W-band EPR to study membrane fluidity profiles in samples of small volume

NASA Astrophysics Data System (ADS)

Mainali, Laxman; Hyde, James S.; Subczynski, Witold K.

2013-01-01

Conventional and saturation-recovery (SR) EPR at W-band (94 GHz) using phosphatidylcholine spin labels (labeled at the alkyl chain [n-PC] and headgroup [T-PC]) to obtain profiles of membrane fluidity has been demonstrated. Dimyristoylphosphatidylcholine (DMPC) membranes with and without 50 mol% cholesterol have been studied, and the results have been compared with similar studies at X-band (9.4 GHz) (L. Mainali, J.B. Feix, J.S. Hyde, W.K. Subczynski, J. Magn. Reson. 212 (2011) 418-425). Profiles of the spin-lattice relaxation rate (T1-1) obtained from SR EPR measurements for n-PCs and T-PC were used as a convenient quantitative measure of membrane fluidity. Additionally, spectral analysis using Freed's MOMD (microscopic-order macroscopic-disorder) model (E. Meirovitch, J.H. Freed J. Phys. Chem. 88 (1984) 4995-5004) provided rotational diffusion coefficients (R⊥ and R||) and order parameters (S0). Spectral analysis at X-band provided one rotational diffusion coefficient, R⊥. T1-1, R⊥, and R|| profiles reflect local membrane dynamics of the lipid alkyl chain, while the order parameter shows only the amplitude of the wobbling motion of the lipid alkyl chain. Using these dynamic parameters, namely T1-1, R⊥, and R||, one can discriminate the different effects of cholesterol at different depths, showing that cholesterol has a rigidifying effect on alkyl chains to the depth occupied by the rigid steroid ring structure and a fluidizing effect at deeper locations. The nondynamic parameter, S0, shows that cholesterol has an ordering effect on alkyl chains at all depths. Conventional and SR EPR measurements with T-PC indicate that cholesterol has a fluidizing effect on phospholipid headgroups. EPR at W-band provides more detailed information about the depth-dependent dynamic organization of the membrane compared with information obtained at X-band. EPR at W-band has the potential to be a powerful tool for studying membrane fluidity in samples of small volume, ˜30 nL, compared with a representative sample volume of ˜3 μL at X-band.

Facial profile parameters and their relative influence on bilabial prominence and the perceptions of facial profile attractiveness: A novel approach

PubMed Central

Denize, Erin Stewart; McDonald, Fraser; Sherriff, Martyn

2014-01-01

Objective To evaluate the relative importance of bilabial prominence in relation to other facial profile parameters in a normal population. Methods Profile stimulus images of 38 individuals (28 female and 10 male; ages 19-25 years) were shown to an unrelated group of first-year students (n = 42; ages 18-24 years). The images were individually viewed on a 17-inch monitor. The observers received standardized instructions before viewing. A six-question questionnaire was completed using a Likert-type scale. The responses were analyzed by ordered logistic regression to identify associations between profile characteristics and observer preferences. The Bayesian Information Criterion was used to select variables that explained observer preferences most accurately. Results Nasal, bilabial, and chin prominences; the nasofrontal angle; and lip curls had the greatest effect on overall profile attractiveness perceptions. The lip-chin-throat angle and upper lip curl had the greatest effect on forehead prominence perceptions. The bilabial prominence, nasolabial angle (particularly the lower component), and mentolabial angle had the greatest effect on nasal prominence perceptions. The bilabial prominence, nasolabial angle, chin prominence, and submental length had the greatest effect on lip prominence perceptions. The bilabial prominence, nasolabial angle, mentolabial angle, and submental length had the greatest effect on chin prominence perceptions. Conclusions More prominent lips, within normal limits, may be considered more attractive in the profile view. Profile parameters have a greater influence on their neighboring aesthetic units but indirectly influence related profile parameters, endorsing the importance of achieving an aesthetic balance between relative prominences of all aesthetic units of the facial profile. PMID:25133133

Evaluation of Thermal Evolution Profiles and Estimation of Kinetic Parameters for Pyrolysis of Coal/Corn Stover Blends Using Thermogravimetric Analysis

DOE PAGES

Bhagavatula, Abhijit; Huffman, Gerald; Shah, Naresh; ...

2014-01-01

The thermal evolution profiles and kinetic parameters for the pyrolysis of two Montana coals (DECS-38 subbituminous coal and DECS-25 lignite coal), one biomass sample (corn stover), and their blends (10%, 20%, and 30% by weight of corn stover) have been investigated at a heating rate of 5°C/min in an inert nitrogen atmosphere, using thermogravimetric analysis. The thermal evolution profiles of subbituminous coal and lignite coal display only one major peak over a wide temperature distribution, ~152–814°C and ~175–818°C, respectively, whereas the thermal decomposition profile for corn stover falls in a much narrower band than that of the coals, ~226–608°C. Themore » nonlinearity in the evolution of volatile matter with increasing percentage of corn stover in the blends verifies the possibility of synergistic behavior in the blends with subbituminous coal where deviations from the predicted yield ranging between 2% and 7% were observed whereas very little deviations (1%–3%) from predicted yield were observed in blends with lignite indicating no significant interactions with corn stover. In addition, a single first-order reaction model using the Coats-Redfern approximation was utilized to predict the kinetic parameters of the pyrolysis reaction. The kinetic analysis indicated that each thermal evolution profile may be represented as a single first-order reaction. Three temperature regimes were identified for each of the coals while corn stover and the blends were analyzed using two and four temperature regimes, respectively.« less

Evaluation of Thermal Evolution Profiles and Estimation of Kinetic Parameters for Pyrolysis of Coal/Corn Stover Blends Using Thermogravimetric Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhagavatula, Abhijit; Huffman, Gerald; Shah, Naresh

The thermal evolution profiles and kinetic parameters for the pyrolysis of two Montana coals (DECS-38 subbituminous coal and DECS-25 lignite coal), one biomass sample (corn stover), and their blends (10%, 20%, and 30% by weight of corn stover) have been investigated at a heating rate of 5°C/min in an inert nitrogen atmosphere, using thermogravimetric analysis. The thermal evolution profiles of subbituminous coal and lignite coal display only one major peak over a wide temperature distribution, ~152–814°C and ~175–818°C, respectively, whereas the thermal decomposition profile for corn stover falls in a much narrower band than that of the coals, ~226–608°C. Themore » nonlinearity in the evolution of volatile matter with increasing percentage of corn stover in the blends verifies the possibility of synergistic behavior in the blends with subbituminous coal where deviations from the predicted yield ranging between 2% and 7% were observed whereas very little deviations (1%–3%) from predicted yield were observed in blends with lignite indicating no significant interactions with corn stover. In addition, a single first-order reaction model using the Coats-Redfern approximation was utilized to predict the kinetic parameters of the pyrolysis reaction. The kinetic analysis indicated that each thermal evolution profile may be represented as a single first-order reaction. Three temperature regimes were identified for each of the coals while corn stover and the blends were analyzed using two and four temperature regimes, respectively.« less

Critical adsorption profiles around a sphere and a cylinder in a fluid at criticality: Local functional theory

NASA Astrophysics Data System (ADS)

Yabunaka, Shunsuke; Onuki, Akira

2017-09-01

We study universal critical adsorption on a solid sphere and a solid cylinder in a fluid at bulk criticality, where preferential adsorption occurs. We use a local functional theory proposed by Fisher et al. [M. E. Fisher and P. G. de Gennes, C. R. Acad. Sci. Paris Ser. B 287, 207 (1978); M. E. Fisher and H. Au-Yang, Physica A 101, 255 (1980), 10.1016/0378-4371(80)90112-0]. We calculate the mean order parameter profile ψ (r ) , where r is the distance from the sphere center and the cylinder axis, respectively. The resultant differential equation for ψ (r ) is solved exactly around a sphere and numerically around a cylinder. A strong adsorption regime is realized except for very small surface field h1, where the surface order parameter ψ (a ) is determined by h1 and is independent of the radius a . If r considerably exceeds a , ψ (r ) decays as r-(1 +η ) for a sphere and r-(1 +η )/2 for a cylinder in three dimensions, where η is the critical exponent in the order parameter correlation at bulk criticality.

An adaptive technique for estimating the atmospheric density profile during the AE mission

NASA Technical Reports Server (NTRS)

Argentiero, P.

1973-01-01

A technique is presented for processing accelerometer data obtained during the AE missions in order to estimate the atmospheric density profile. A minimum variance, adaptive filter is utilized. The trajectory of the probe and probe parameters are in a consider mode where their estimates are unimproved but their associated uncertainties are permitted an impact on filter behavior. Simulations indicate that the technique is effective in estimating a density profile to within a few percentage points.

The Blume-Capel model on hierarchical lattices: Exact local properties

NASA Astrophysics Data System (ADS)

Rocha-Neto, Mário J. G.; Camelo-Neto, G.; Nogueira, E., Jr.; Coutinho, S.

2018-03-01

The local properties of the spin one ferromagnetic Blume-Capel model defined on hierarchical lattices with dimension two and three are obtained by a numerical recursion procedure and studied as functions of the temperature and the reduced crystal-field parameter. The magnetization and the density of sites in the configuration S = 0 state are carefully investigated at low temperature in the region of the phase diagram that presents the phenomenon of phase reentrance. Both order parameters undergo transitions from the ferromagnetic to the ordered paramagnetic phase with abrupt discontinuities that decrease along the phase boundary at low temperatures. The distribution of magnetization in a typical profile was determined on the transition line presenting a broad multifractal spectrum that narrows towards the fractal limit (single point) as the discontinuities of the order parameters grow towards a maximum. The amplitude of the order-parameter discontinuities and the narrowing of the multifractal spectra were used to delimit the low temperature interval for the possible locus of the tricritical point.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johannsen, Tim; Psaltis, Dimitrios

According to the no-hair theorem, astrophysical black holes are fully characterized by their masses and spins and are described by the Kerr metric. This theorem can be tested observationally by measuring (at least) three different multipole moments of the spacetimes of black holes. In this paper, we calculate the profiles of fluorescent iron lines emitted from the accretion flows around black hole candidates within a framework that allows us to perform the calculation as a function of its mass and spin as well as of a free parameter that measures potential deviations from the Kerr metric. We show that suchmore » deviations lead to line profiles that are significantly altered and may exhibit a modified flux ratio of the two peaks in their characteristic double-peaked shape. We also show that the disk inclination can be measured independently of the spin and the deviation parameter at low to intermediate inclination angles, as in the case of Kerr black holes. We estimate the precision that near-future X-ray missions such as Astro-H and ATHENA+ are required to achieve in order to resolve deviations from the Kerr metric in iron line profiles and show that constraints on such deviations will be strongest for rapidly spinning black holes. More generally, we show that measuring the line profile with a precision of {approx}5% at disk inclinations of 30 Degree-Sign or 60 Degree-Sign constrains the deviation parameter to order unity for values of the spin a {approx}> 0.5M.« less

Analysis of earing behaviour in deep drawing of ASS 304 at elevated temperature

NASA Astrophysics Data System (ADS)

Gupta, Amit Kumar; Deole, Aditya; Kotkunde, Nitin; Singh, Swadesh Kumar; jella, Gangadhar

2016-08-01

Earing tendency in a deep drawn cup of circular blanks is one the most prominent characteristics observed due to anisotropy in a metal sheet. Such formation of uneven rim is mainly due to dissimilarity in yield stress as well as Lankford parameter (r- value) in different orientations. In this paper, an analytical function coupled with different yield functions viz., Hill 1948, Barlat 1989 and Barlat Yld 2000-2d has been used to provide an approximation of earing profile. In order to validate the results, material parameters for yield functions and hardening rule have been calibrated for ASS 304 at 250°C and deep drawing experiment is conducted to measure the earing profile. The predicted earing profiles based on analytical results have been validated using experimental earing profile. Based on this analysis, Barlat Yld 2000-2d has been observed to be a well suited yield model for deep drawing of ASS 304, which also confirms the reliability of analytical function for earing profile estimation.

Order and anarchy hand in hand in 5D SO(10)

NASA Astrophysics Data System (ADS)

Feruglio, Ferruccio; Patel, Ketan M.; Vicino, Denise

2014-09-01

We update a five-dimensional SO(10) grand unified model of fermion masses and mixing angles originally proposed by Kitano and Li. In our setup Yukawa couplings are anarchical and quark and lepton sectors are diversified by the profiles of the fermion zero modes in the extra dimension. The breaking of SO(10) down to SU(5)×U(1)X provides the key parameter that distinguishes the profiles of the different SU(5) components inside the same 16 representation. With respect to the original version of the model, we extend the Higgs sector to explicitly solve the doublet-triplet splitting problem through the missing partner mechanism and we perform a fit to an idealized set of data. By scanning the Yukawa couplings of the model we find that, for large tan β, both normal and inverted ordered neutrino spectrum can be accommodated. However, while the case of inverted order requires a severe fine tuning of the Yukawa parameters, the normal ordering is compatible with an anarchical distribution of Yukawa couplings. Thus, in a natural portion of the parameter space, the model predicts a normal ordered neutrino spectrum, the lightest neutrino mass below 5 meV, and | m ββ | in the range 0.1-5 meV. No particular preference is found for the Dirac CP phase in the lepton sector while the right-handed neutrino masses are too small to explain the baryon asymmetry of the universe through thermal leptogenesis.

Inverse analysis of water profile in starch by non-contact photopyroelectric method

NASA Astrophysics Data System (ADS)

Frandas, A.; Duvaut, T.; Paris, D.

2000-07-01

The photopyroelectric (PPE) method in a non-contact configuration was proposed to study water migration in starch sheets used for biodegradable packaging. A 1-D theoretical model was developed, allowing the study of samples having a water profile characterized by an arbitrary continuous function. An experimental setup was designed or this purpose which included the choice of excitation source, detection of signals, signal and data processing, and cells for conditioning the samples. We report here the development of an inversion procedure allowing for the determination of the parameters that influence the PPE signal. This procedure led to the optimization of experimental conditions in order to identify the parameters related to the water profile in the sample, and to monitor the dynamics of the process.

Complex free-energy landscapes in biaxial nematic liquid crystals and the role of repulsive interactions: A Wang-Landau study

NASA Astrophysics Data System (ADS)

Kamala Latha, B.; Murthy, K. P. N.; Sastry, V. S. S.

2017-09-01

General quadratic Hamiltonian models, describing the interaction between liquid-crystal molecules (typically with D2 h symmetry), take into account couplings between their uniaxial and biaxial tensors. While the attractive contributions arising from interactions between similar tensors of the participating molecules provide for eventual condensation of the respective orders at suitably low temperatures, the role of cross coupling between unlike tensors is not fully appreciated. Our recent study with an advanced Monte Carlo technique (entropic sampling) showed clearly the increasing relevance of this cross term in determining the phase diagram (contravening in some regions of model parameter space), the predictions of mean-field theory, and standard Monte Carlo simulation results. In this context, we investigated the phase diagrams and the nature of the phases therein on two trajectories in the parameter space: one is a line in the interior region of biaxial stability believed to be representative of the real systems, and the second is the extensively investigated parabolic path resulting from the London dispersion approximation. In both cases, we find the destabilizing effect of increased cross-coupling interactions, which invariably result in the formation of local biaxial organizations inhomogeneously distributed. This manifests as a small, but unmistakable, contribution of biaxial order in the uniaxial phase. The free-energy profiles computed in the present study as a function of the two dominant order parameters indicate complex landscapes. On the one hand, these profiles account for the unusual thermal behavior of the biaxial order parameter under significant destabilizing influence from the cross terms. On the other, they also allude to the possibility that in real systems, these complexities might indeed be inhibiting the formation of a low-temperature biaxial order itself—perhaps reflecting the difficulties in their ready realization in the laboratory.

Adaptive method for electron bunch profile prediction

DOE PAGES

Scheinker, Alexander; Gessner, Spencer

2015-10-15

We report on an experiment performed at the Facility for Advanced Accelerator Experimental Tests (FACET) at SLAC National Accelerator Laboratory, in which a new adaptive control algorithm, one with known, bounded update rates, despite operating on analytically unknown cost functions, was utilized in order to provide quasi-real-time bunch property estimates of the electron beam. Multiple parameters, such as arbitrary rf phase settings and other time-varying accelerator properties, were simultaneously tuned in order to match a simulated bunch energy spectrum with a measured energy spectrum. Thus, the simple adaptive scheme was digitally implemented using matlab and the experimental physics and industrialmore » control system. Finally, the main result is a nonintrusive, nondestructive, real-time diagnostic scheme for prediction of bunch profiles, as well as other beam parameters, the precise control of which are important for the plasma wakefield acceleration experiments being explored at FACET.« less

Adaptive method for electron bunch profile prediction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scheinker, Alexander; Gessner, Spencer

2015-10-01

We report on an experiment performed at the Facility for Advanced Accelerator Experimental Tests (FACET) at SLAC National Accelerator Laboratory, in which a new adaptive control algorithm, one with known, bounded update rates, despite operating on analytically unknown cost functions, was utilized in order to provide quasi-real-time bunch property estimates of the electron beam. Multiple parameters, such as arbitrary rf phase settings and other time-varying accelerator properties, were simultaneously tuned in order to match a simulated bunch energy spectrum with a measured energy spectrum. The simple adaptive scheme was digitally implemented using matlab and the experimental physics and industrial controlmore » system. The main result is a nonintrusive, nondestructive, real-time diagnostic scheme for prediction of bunch profiles, as well as other beam parameters, the precise control of which are important for the plasma wakefield acceleration experiments being explored at FACET. © 2015 authors. Published by the American Physical Society.« less

Strength analysis of welded corners of PVC window profiles

NASA Astrophysics Data System (ADS)

Postawa, P.; Stachowiak, T.; Gnatowski, A.

2017-08-01

The article presents the results of researches which main purpose was to define the influence of welding parameters on strength of welded corners of PVC window profile. PVC profiles of a branded name GENEO® produced by Rehau Company were used for this research. The profiles were made by using a co-extrusion method. The surface of the profile was made of PVC mixture with no additives. Its main task was to get a smooth surface resistant to a smudge. The use of an unfilled polyester provides an aesthetic look and improves the resistance of extrudate to water getting into inner layers. The profile's inner layers have been filled up with glass fibre in order to improve its stiffness and mechanical properties. Window frames with cut corners used for this research, were produced on technological line of EUROCOLOR Company based in Pyskowice (Poland). The main goal of this analysis was to evaluate the influence of the main welding parameter (temperature upsetting) on hardness of welds we received in whole process. A universal testing machine was used for the research.

Optimum Laser Beam Characteristics for Achieving Smoother Ablations in Laser Vision Correction.

PubMed

Verma, Shwetabh; Hesser, Juergen; Arba-Mosquera, Samuel

2017-04-01

Controversial opinions exist regarding optimum laser beam characteristics for achieving smoother ablations in laser-based vision correction. The purpose of the study was to outline a rigorous simulation model for simulating shot-by-shot ablation process. The impact of laser beam characteristics like super Gaussian order, truncation radius, spot geometry, spot overlap, and lattice geometry were tested on ablation smoothness. Given the super Gaussian order, the theoretical beam profile was determined following Lambert-Beer model. The intensity beam profile originating from an excimer laser was measured with a beam profiler camera. For both, the measured and theoretical beam profiles, two spot geometries (round and square spots) were considered, and two types of lattices (reticular and triangular) were simulated with varying spot overlaps and ablated material (cornea or polymethylmethacrylate [PMMA]). The roughness in ablation was determined by the root-mean-square per square root of layer depth. Truncating the beam profile increases the roughness in ablation, Gaussian profiles theoretically result in smoother ablations, round spot geometries produce lower roughness in ablation compared to square geometry, triangular lattices theoretically produce lower roughness in ablation compared to the reticular lattice, theoretically modeled beam profiles show lower roughness in ablation compared to the measured beam profile, and the simulated roughness in ablation on PMMA tends to be lower than on human cornea. For given input parameters, proper optimum parameters for minimizing the roughness have been found. Theoretically, the proposed model can be used for achieving smoothness with laser systems used for ablation processes at relatively low cost. This model may improve the quality of results and could be directly applied for improving postoperative surface quality.

SAGE III L2 Lunar Event Species Profiles (Binary)

Atmospheric Science Data Center

2017-10-27

... Search and Order:  Earthdata Search   FTP Access:  Data Pool Parameters:  Chlorine Dioxide Nitrogen Dioxide ... Data Additional Info:  Data Format: Big Endian/IEEE Binary; Avg Size in MB: 0.017 SCAR-B Block:  ...

Young addicted men hormone profile detection

NASA Astrophysics Data System (ADS)

Zieliński, Paweł; Wasiewicz, Piotr; Leszczyńska, Bożena; Gromadzka-Ostrowska, Joanna

2010-09-01

Hormone parameters were determined in the serum of young addicted men in order to compare them with those obtained from the group of healthy subjects. Three groups were investigated which were named opiates, mixed and control group. Statistical and data mining methods were applied to obtain significant differences. R package was used for all computation. The determination of hormones parameters provide important information relative to impact of addiction.

Dynamical phase transitions in generalized Kuramoto model with distributed Sakaguchi phase

NASA Astrophysics Data System (ADS)

Banerjee, Amitava

2017-11-01

In this numerical work, we have systematically studied the dynamical phase transitions in the Kuramoto-Sakaguchi model of synchronizing phase oscillators controlled by disorder in the Sakaguchi phases. We derive the numerical steady state phase diagrams for quenched and annealed kinds of disorder in the Sakaguchi parameters, using the conventional order parameter and other such statistical quantities as strength of incoherence and discontinuity measures. We have also considered the correlation profile of the local order parameter fluctuations in the various phases identified. The phase diagrams for quenched disorder are qualitatively much different from those in the global coupling regime. The order of various transitions is confirmed by a study of the distribution of the order parameter and its fourth order Binder’s cumulant across the transition for an ensemble of initial distribution of phases. For the annealed type of disorder, in contrast to the case with quenched disorder, the system is almost insensitive to the amount of disorder. We also elucidate the role of chimeralike states in the synchronizing transition of the system, and study the effect of disorder on these states. Finally, we seek justification of our results from simulations guided by the Ott-Antonsen ansatz.

PyLDTk: Python toolkit for calculating stellar limb darkening profiles and model-specific coefficients for arbitrary filters

NASA Astrophysics Data System (ADS)

Parviainen, Hannu

2015-10-01

PyLDTk automates the calculation of custom stellar limb darkening (LD) profiles and model-specific limb darkening coefficients (LDC) using the library of PHOENIX-generated specific intensity spectra by Husser et al. (2013). It facilitates exoplanet transit light curve modeling, especially transmission spectroscopy where the modeling is carried out for custom narrow passbands. PyLDTk construct model-specific priors on the limb darkening coefficients prior to the transit light curve modeling. It can also be directly integrated into the log posterior computation of any pre-existing transit modeling code with minimal modifications to constrain the LD model parameter space directly by the LD profile, allowing for the marginalization over the whole parameter space that can explain the profile without the need to approximate this constraint by a prior distribution. This is useful when using a high-order limb darkening model where the coefficients are often correlated, and the priors estimated from the tabulated values usually fail to include these correlations.

Clinical symptoms in fibromyalgia are associated to overweight and lipid profile.

PubMed

Cordero, Mario D; Alcocer-Gómez, Elísabet; Cano-García, Francisco J; Sánchez-Domínguez, Benito; Fernández-Riejo, Patricia; Moreno Fernández, Ana M; Fernández-Rodríguez, Ana; De Miguel, Manuel

2014-03-01

In order to analyze the association between body mass index (BMI), lipid profile and clinical symptoms in patients with fibromyalgia, we assessed BMI levels, lipid profile and its association with clinical symptoms in 183 patients with fibromyalgia. The patients were evaluated using tender points, FIQ and Visual Analogue Scales of pain (VAS). Serum lipid profile analysis (total cholesterol, triglyceride, HDL, LDL and VLDL), and biochemical parameters were measured in the biochemistry laboratory. The BMI distribution of the nonobese, overweight and obese patients' groups were relatively even with 37.7, 35.5 and 26.8%, respectively, with a mean BMI of 27.3 ± 4.9. The number of tender points showed significantly positive correlation with higher BMI (P < 0.05). A total of 57.9% of patients showed increased levels of total cholesterol, 63.4 % increased levels of LDL cholesterol and 19.9% high levels of triglycerides. BMI, total cholesterol and triglycerides showed high association with some clinical parameters. Overweight and lipid profile could be associated with fibromyalgia symptoms. A treatment program with weight loss strategies, and control in diet and increased physical activity is advised to patients.

Time scale variations of the physical parameters of the Si IV resonance lines in the case of the Be star HD 50138

NASA Astrophysics Data System (ADS)

Stathopoulos, D.

2012-01-01

As it is well known many lines in the spectra of hot emission stars (Be and Oe) present peculiar and very complex profiles. As a result, we cannot find a classical theoretical distribution in order to fit these profiles. Because of this, we are not able to calculate the physical parameters of the regions were these lines are created. In this paper, using the Gauss-Rotation model (GR-model Danezis et al), that proposed the idea that these complex profiles consist of a number of independent Discrete or Satellite Absorption Components (DACs, SACs), we study the UV Si IV (λλ 1393.755, 1402.77 A) resonance lines of the Be star HD 50138 in three different periods. From this analysis we can calculate the values of a group of physical parameters. The parameters are the apparent rotational and radial velocities, the random velocities of the thermal motions of the ions, as well as the Full Width at Half Maximum (FWHM) an the absorbed energy of the independent regions of matter which produce the main and the satellite components of the studied spectral line. Finally we calculate the time scale variations of the above physical parameters.

Impurity profiles and radial transport in the EXTRAP-T2 reversed field pinch

NASA Astrophysics Data System (ADS)

Sallander, J.

1999-05-01

Radially resolved spectroscopy has been used to measure the radial distribution of impurity ions (O III-O V and C III-CVI) in the EXTRAP-T2 reversed field pinch (RFP). The radial profile of the emission is reconstructed from line emission measured along five lines of sight. The ion density profile is the fitted quantity in the reconstruction of the brightness profile and is thus obtained directly in this process. These measurements are then used to adjust the parameters in transport calculations in order to obtain consistency with the observed ion density profiles. Comparison between model and measurements show that a radial dependence in the diffusion is needed to explain the measured ion densities.

Velocity Profile measurements in two-phase flow using multi-wave sensors

NASA Astrophysics Data System (ADS)

Biddinika, M. K.; Ito, D.; Takahashi, H.; Kikura, H.; Aritomi, M.

2009-02-01

Two-phase flow has been recognized as one of the most important phenomena in fluid dynamics. In addition, gas-liquid two-phase flow appears in various industrial fields such as chemical industries and power generations. In order to clarify the flow structure, some flow parameters have been measured by using many effective measurement techniques. The velocity profile as one of the important flow parameter, has been measured by using ultrasonic velocity profile (UVP) technique. This technique can measure velocity distributions along a measuring line, which is a beam formed by pulse ultrasounds. Furthermore, a multi-wave sensor can measure the velocity profiles of both gas and liquid phase using UVP method. In this study, two types of multi-wave sensors are used. A sensor has cylindrical shape, and another one has square shape. The piezoelectric elements of each sensor have basic frequencies of 8 MHz for liquid phase and 2 MHz for gas phase, separately. The velocity profiles of air-water bubbly flow in a vertical rectangular channel were measured by using these multi-wave sensors, and the validation of the measuring accuracy was performed by the comparison between the velocity profiles measured by two multi-wave sensors.

Pressure profiles of the BRing based on the simulation used in the CSRm

NASA Astrophysics Data System (ADS)

Wang, J. C.; Li, P.; Yang, J. C.; Yuan, Y. J.; Wu, B.; Chai, Z.; Luo, C.; Dong, Z. Q.; Zheng, W. H.; Zhao, H.; Ruan, S.; Wang, G.; Liu, J.; Chen, X.; Wang, K. D.; Qin, Z. M.; Yin, B.

2017-07-01

HIAF-BRing, a new multipurpose accelerator facility of the High Intensity heavy-ion Accelerator Facility project, requires an extremely high vacuum lower than 10-11 mbar to fulfill the requirements of radioactive beam physics and high energy density physics. To achieve the required process pressure, the bench-marked codes of VAKTRAK and Molflow+ are used to simulate the pressure profiles of the BRing system. In order to ensure the accuracy of the implementation of VAKTRAK, the computational results are verified by measured pressure data and compared with a new simulation code BOLIDE on the current synchrotron CSRm. Since the verification of VAKTRAK has been done, the pressure profiles of the BRing are calculated with different parameters such as conductance, out-gassing rates and pumping speeds. According to the computational results, the optimal parameters are selected to achieve the required pressure for the BRing.

SAGE III L2 Solar Event Species Profiles (Binary)

Atmospheric Science Data Center

2016-06-14

... Search and Order:  Earthdata Search   FTP Access:  Data Pool V3  |  Data Pool V4 Parameters:  Aerosol ... Data Additional Info:  Data Format: Big Endian/IEEE Binary; Avg Size in MB: 0.044 SCAR-B Block:  ...

Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process

PubMed Central

Djuriš, Jelena; Medarević, Djordje; Krstić, Marko; Vasiljević, Ivana; Mašić, Ivana; Ibrić, Svetlana

2012-01-01

The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach. Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters. They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design. Type of diluent and atomization pressure were selected as the most important parameters. In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed. Percent of paracetamol released and tablets hardness were determined as critical quality attributes. Artificial neural networks (ANNs) were applied in order to determine design space. ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness. Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors. PMID:22919295

Unsteady boundary layer flow over a sphere in a porous medium

NASA Astrophysics Data System (ADS)

Mohammad, Nurul Farahain; Waini, Iskandar; Kasim, Abdul Rahman Mohd; Majid, Nurazleen Abdul

2017-08-01

This study focuses on the problem of unsteady boundary layer flow over a sphere in a porous medium. The governing equations which consists of a system of dimensional partial differential equations is applied with dimensionless parameter in order to attain non-dimensional partial differential equations. Later, the similarity transformation is performed in order to attain nonsimilar governing equations. Afterwards, the nonsimilar governing equations are solved numerically by using the Keller-Box method in Octave programme. The effect of porosity parameter is examined on separation time, velocity profile and skin friction of the unsteady flow. The results attained are presented in the form of table and graph.

Steady boundary layer slip flow along with heat and mass transfer over a flat porous plate embedded in a porous medium.

PubMed

Aziz, Asim; Siddique, J I; Aziz, Taha

2014-01-01

In this paper, a simplified model of an incompressible fluid flow along with heat and mass transfer past a porous flat plate embedded in a Darcy type porous medium is investigated. The velocity, thermal and mass slip conditions are utilized that has not been discussed in the literature before. The similarity transformations are used to transform the governing partial differential equations (PDEs) into a nonlinear ordinary differential equations (ODEs). The resulting system of ODEs is then reduced to a system of first order differential equations which was solved numerically by using Matlab bvp4c code. The effects of permeability, suction/injection parameter, velocity parameter and slip parameter on the structure of velocity, temperature and mass transfer rates are examined with the aid of several graphs. Moreover, observations based on Schmidt number and Soret number are also presented. The result shows, the increase in permeability of the porous medium increase the velocity and decrease the temperature profile. This happens due to a decrease in drag of the fluid flow. In the case of heat transfer, the increase in permeability and slip parameter causes an increase in heat transfer. However for the case of increase in thermal slip parameter there is a decrease in heat transfer. An increase in the mass slip parameter causes a decrease in the concentration field. The suction and injection parameter has similar effect on concentration profile as for the case of velocity profile.

Steady Boundary Layer Slip Flow along with Heat and Mass Transfer over a Flat Porous Plate Embedded in a Porous Medium

PubMed Central

Aziz, Asim; Siddique, J. I.; Aziz, Taha

2014-01-01

In this paper, a simplified model of an incompressible fluid flow along with heat and mass transfer past a porous flat plate embedded in a Darcy type porous medium is investigated. The velocity, thermal and mass slip conditions are utilized that has not been discussed in the literature before. The similarity transformations are used to transform the governing partial differential equations (PDEs) into a nonlinear ordinary differential equations (ODEs). The resulting system of ODEs is then reduced to a system of first order differential equations which was solved numerically by using Matlab bvp4c code. The effects of permeability, suction/injection parameter, velocity parameter and slip parameter on the structure of velocity, temperature and mass transfer rates are examined with the aid of several graphs. Moreover, observations based on Schmidt number and Soret number are also presented. The result shows, the increase in permeability of the porous medium increase the velocity and decrease the temperature profile. This happens due to a decrease in drag of the fluid flow. In the case of heat transfer, the increase in permeability and slip parameter causes an increase in heat transfer. However for the case of increase in thermal slip parameter there is a decrease in heat transfer. An increase in the mass slip parameter causes a decrease in the concentration field. The suction and injection parameter has similar effect on concentration profile as for the case of velocity profile. PMID:25531301

Microstructural characterisation of proton irradiated niobium using X-ray diffraction technique

NASA Astrophysics Data System (ADS)

Dutta, Argha; Gayathri, N.; Neogy, S.; Mukherjee, P.

2018-04-01

The microstructural parameters in pure Nb, irradiated with 5 MeV proton beam have been evaluated as a function of dose using X-ray diffraction line profile analysis. In order to assess the microstructural changes in the homogeneous region and in the peak damage region of the damage energy deposition profile, X-ray diffraction patterns have been collected using two different geometries (Bragg-Brentano and parallel beam geometries). Different X-ray line profile analysis like Williamson-Hall (W-H) analysis, modified W-H analysis, double-Voigt analysis, modified Rietveld technique and convolutional multiple whole profile fitting have been employed to extract the microstructural parameters like coherent domain size, microstrain within the domain, dislocation density and arrangement of dislocations. The coherent domain size decreases drastically along with increase in microstrain and dislocation density in the first dose for both the geometries. With increasing dose, a decreasing trend in microstrain associated with decrease in dislocation density is observed for both the geometries. This is attributed to the formation of defect clusters due to irradiation which with increasing dose collapse to dislocation loops to minimise the strain in the matrix. This is corroborated with the observation of black dots and loops in the TEM images. No significant difference is observed in the trend of microstructural parameters between the homogeneous and peak damage region of the damage profile.

Spectral Line-Shape Model to Replace the Voigt Profile in Spectroscopic Databases

NASA Astrophysics Data System (ADS)

Lisak, Daniel; Ngo, Ngoc Hoa; Tran, Ha; Hartmann, Jean-Michel

2014-06-01

The standard description of molecular line shapes in spectral databases and radiative transfer codes is based on the Voigt profile. It is well known that its simplified assumptions of absorber free motion and independence of collisional parameters from absorber velocity lead to systematic errors in analysis of experimental spectra, and retrieval of gas concentration. We demonstrate1,2 that the partially correlated quadratic speed-dependent hardcollision profile3. (pCqSDHCP) is a good candidate to replace the Voigt profile in the next generations of spectroscopic databases. This profile takes into account the following physical effects: the Doppler broadening, the pressure broadening and shifting of the line, the velocity-changing collisions, the speed-dependence of pressure broadening and shifting, and correlations between velocity- and phase/state-changing collisions. The speed-dependence of pressure broadening and shifting is incorporated into the pCqSDNGP in the so-called quadratic approximation. The velocity-changing collisions lead to the Dicke narrowing effect; however in many cases correlations between velocityand phase/state-changing collisions may lead to effective reduction of observed Dicke narrowing. The hard-collision model of velocity-changing collisions is also known as the Nelkin-Ghatak model or Rautian model. Applicability of the pCqSDHCP for different molecular systems was tested on calculated and experimental spectra of such molecules as H2, O2, CO2, H2O in a wide span of pressures. For all considered systems, pCqSDHCP is able to describe molecular spectra at least an order of magnitude better than the Voigt profile with all fitted parameters being linear with pressure. In the most cases pCqSDHCP can reproduce the reference spectra down to 0.2% or better, which fulfills the requirements of the most demanding remote-sensing applications. An important advantage of pCqSDHCP is that a fast algorithm for its computation was developedab4,5 and allows for its calculation only a few times slower than the standard Voigt profile. Moreover, the pCqSDHCP reduces to many simpler models commonly used in experimental spectra analysis simply by setting some parameters to zero, and it can be easily extended to incorporate the line-mixing effect in the first-order approximation. The idea of using pCqSDHCP as a standard profile to go beyond the Voigt profile for description of H2O line shapes was recently supported by the IUPAC task group6 which also recommended to call this profile with fast computation algorithm the HTP profile (for Hartmann-Tran).

Chemical reaction and radiation effects on MHD flow past an exponentially stretching sheet with heat sink

NASA Astrophysics Data System (ADS)

Nur Wahida Khalili, Noran; Aziz Samson, Abdul; Aziz, Ahmad Sukri Abdul; Ali, Zaileha Md

2017-09-01

In this study, the problem of MHD boundary layer flow past an exponentially stretching sheet with chemical reaction and radiation effects with heat sink is studied. The governing system of PDEs is transformed into a system of ODEs. Then, the system is solved numerically by using Runge-Kutta-Fehlberg fourth fifth order (RKF45) method available in MAPLE 15 software. The numerical results obtained are presented graphically for the velocity, temperature and concentration. The effects of various parameters are studied and analyzed. The numerical values for local Nusselt number, skin friction coefficient and local Sherwood number are tabulated and discussed. The study shows that various parameters give significant effect on the profiles of the fluid flow. It is observed that the reaction rate parameter affected the concentration profiles significantly and the concentration thickness of boundary layer decreases when reaction rate parameter increases. The analysis found is validated by comparing with the results previous work done and it is found to be in good agreement.

Keep-Left Behavior Induced by Asymmetrically Profiled Walls

NASA Astrophysics Data System (ADS)

Oliveira, C. L. N.; Vieira, A. P.; Helbing, D.; Andrade, J. S.; Herrmann, H. J.

2016-01-01

We show, computationally and analytically, that asymmetrically shaped walls can organize the flow of pedestrians driven in opposite directions through a corridor. Precisely, a two-lane ordered state emerges in which people always walk on the left-hand side (or right-hand side), controlled by the system's parameters. This effect depends on features of the channel geometry, such as the asymmetry of the profile and the channel width, as well as on the density and the drift velocity of pedestrians, and the intensity of noise. We investigate in detail the influence of these parameters on the flow and discover a crossover between ordered and disordered states. Our results show that an ordered state only appears within a limited range of drift velocities. Moreover, increasing noise may suppress such flow organization, but the flow is always sustained. This is in contrast with the "freezing by heating" phenomenon according to which pedestrians tend to clog in smooth channels for strong noise [Phys. Rev. Lett. 84, 1240 (2000)]. Therefore, the ratchetlike effect proposed here acts on the system not only to induce a "keep-left" behavior but also to prevent the freezing by heating clogging phenomenon. Besides pedestrian flow, this new phenomenon has other potential applications in microfluidics systems.

Profiles of ion beams and plasma parameters on a multi-frequencies microwaves large bore electron cyclotron resonance ion source with permanent magnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kato, Yushi; Sakamoto, Naoki; Kiriyama, Ryutaro

2012-02-15

In order to contribute to various applications of plasma and beams based on an electron cyclotron resonance, a new concept on magnetic field with all magnets on plasma production and confinement has been proposed with enhanced efficiency for broad and dense ion beam. The magnetic field configuration consists of a pair of comb-shaped magnet surrounding plasma chamber cylindrically. Resonance zones corresponding for 2.45 GHz and 11-13 GHz frequencies are positioned at spatially different positions. We launch simultaneously multiplex frequencies microwaves operated individually, try to control profiles of the plasma parameters and the extracted ion beams, and to measure them inmore » detail.« less

Watershed Profiles and Stream-net Structure of Vesuvio Volcano, Italy

NASA Astrophysics Data System (ADS)

Lin, Z.; Oguchi, T.; Komatsu, G.

2006-12-01

Watershed topography including stream-net structure in 32 watersheds of Vesuvio Volcano was analyzed using a DEM with a 20-m resolution, with special attention to geomorphological differences between the northern ?0-8 area and the other areas. The longitudinal and transverse profiles and stream-nets of the watersheds were extracted from the DEM. Drainage density and statistical morphometric parameters representing the shape of the profiles were investigated, and their relations with other basic morphometric parameters such as slope angle were examined. The relationships between drainage density and slope angle for each watershed can be divided into two types: Type 1 - negative correlation and Type 2 - convex-form correlation. The Type 2 watersheds have smaller bifurcation ratios and larger low-order stream lengths than the Type 1 watersheds, indicating that low-order streams in the Type 2 watersheds are more integrated. The results of longitudinal and transverse profile analyses also show that the topography of the Type 2 watersheds is simpler and more organized than that of the Type 1 watersheds, suggesting that the Type 2 watersheds are closer to equilibrium conditions. The Type 2 watersheds are located in the steepest and highest part of the somma area, where only limited eruption products have been deposited during the Holocene, due to the existence of the high and steep outer rim of the caldera at the top of the volcano. The results including the existence of the two types are similar to those from non-volcanic watersheds in Japan, indicating that stream-net studies combined with profile analysis using DEMs are effective in discussing the erosional stages of watersheds.

Seabed roughness parameters from joint backscatter and reflection inversion at the Malta Plateau.

PubMed

Steininger, Gavin; Holland, Charles W; Dosso, Stan E; Dettmer, Jan

2013-09-01

This paper presents estimates of seabed roughness and geoacoustic parameters and uncertainties on the Malta Plateau, Mediterranean Sea, by joint Bayesian inversion of mono-static backscatter and spherical wave reflection-coefficient data. The data are modeled using homogeneous fluid sediment layers overlying an elastic basement. The scattering model assumes a randomly rough water-sediment interface with a von Karman roughness power spectrum. Scattering and reflection data are inverted simultaneously using a population of interacting Markov chains to sample roughness and geoacoustic parameters as well as residual error parameters. Trans-dimensional sampling is applied to treat the number of sediment layers and the order (zeroth or first) of an autoregressive error model (to represent potential residual correlation) as unknowns. Results are considered in terms of marginal posterior probability profiles and distributions, which quantify the effective data information content to resolve scattering/geoacoustic structure. Results indicate well-defined scattering (roughness) parameters in good agreement with existing measurements, and a multi-layer sediment profile over a high-speed (elastic) basement, consistent with independent knowledge of sand layers over limestone.

Velocity and thermal slip effects on MHD third order blood flow in an irregular channel though a porous medium with homogeneous/ heterogeneous reactions

NASA Astrophysics Data System (ADS)

Gnaneswara Reddy, M.

2017-09-01

This communication presents the transportation of third order hydromagnetic fluid with thermal radiation by peristalsis through an irregular channel configuration filled a porous medium under the low Reynolds number and large wavelength approximations. Joule heating, Hall current and homogeneous-heterogeneous reactions effects are considered in the energy and species equations. The Second-order velocity and energy slip restrictions are invoked. Final dimensionless governing transport equations along the boundary restrictions are resolved numerically with the help of NDsolve in Mathematica package. Impact of involved sundry parameters on the non-dimensional axial velocity, fluid temperature and concentration characteristics have been analyzed via plots and tables. It is manifest that an increasing porosity parameter leads to maximum velocity in the core part of the channel. Fluid velocity boosts near the walls of the channel where as the reverse effect in the central part of the channel for higher values of first order slip. Larger values of thermal radiation parameter R reduce the fluid temperature field. Also, an increase in heterogeneous reaction parameter Ks magnifies the concentration profile. The present study has the crucial application of thermal therapy in biomedical engineering.

A sustainable solid state recycling of pure aluminum by means of friction stir extrusion process (FSE)

NASA Astrophysics Data System (ADS)

Mehtedi, Mohamad El; Forcellese, Archimede; Simoncini, Michela; Spigarelli, Stefano

2018-05-01

In this research, the feasibility of solid-state recycling of pure aluminum AA1099 machining chips using FSE process is investigated. In the early stage, a FE simulation was conducted in order to optimize the die design and the process parameters in terms of plunge rotational speed and extrusion rate. The AA1099 aluminum chips were produced by turning of an as-received bar without lubrication. The chips were compacted on a MTS machine up to 150KN of load. The extruded samples were analyzed by optical and electron microscope in order to see the material flow and to characterize the microstructure. Finally, micro-hardness Vickers profiles were carried out, in both longitudinal and transversal direction of the obtained profiles, in order to investigate the homogeneity of the mechanical properties of the extrudate.

Monte Carlo study of one-dimensional confined fluids with Gay-Berne intermolecular potential

NASA Astrophysics Data System (ADS)

Moradi, M.; Hashemi, S.

2011-11-01

The thermodynamic quantities of a one dimensional system of particles with Gay-Berne model potential confined between walls have been obtained by means of Monte Carlo computer simulations. For a number of temperatures, the systems were considered and their density profiles, order parameter, pressure, configurational temperature and average potential energy per particle are reported. The results show that by decreasing the temperature, the soft particles become more ordered and they align to the walls and also they don't show any tendency to be near the walls at very low temperatures. We have also changed the structure of the walls by embedding soft ellipses in them, this change increases the total density near the wall whereas, increasing or decreasing the order parameter depend on the angle of embedded ellipses.

A statistical survey of heat input parameters into the cusp thermosphere

NASA Astrophysics Data System (ADS)

Moen, J. I.; Skjaeveland, A.; Carlson, H. C.

2017-12-01

Based on three winters of observational data, we present those ionosphere parameters deemed most critical to realistic space weather ionosphere and thermosphere representation and prediction, in regions impacted by variability in the cusp. The CHAMP spacecraft revealed large variability in cusp thermosphere densities, measuring frequent satellite drag enhancements, up to doublings. The community recognizes a clear need for more realistic representation of plasma flows and electron densities near the cusp. Existing average-value models produce order of magnitude errors in these parameters, resulting in large under estimations of predicted drag. We fill this knowledge gap with statistics-based specification of these key parameters over their range of observed values. The EISCAT Svalbard Radar (ESR) tracks plasma flow Vi , electron density Ne, and electron, ion temperatures Te, Ti , with consecutive 2-3 minute windshield-wipe scans of 1000x500 km areas. This allows mapping the maximum Ti of a large area within or near the cusp with high temporal resolution. In magnetic field-aligned mode the radar can measure high-resolution profiles of these plasma parameters. By deriving statistics for Ne and Ti , we enable derivation of thermosphere heating deposition under background and frictional-drag-dominated magnetic reconnection conditions. We separate our Ne and Ti profiles into quiescent and enhanced states, which are not closely correlated due to the spatial structure of the reconnection foot point. Use of our data-based parameter inputs can make order of magnitude corrections to input data driving thermosphere models, enabling removal of previous two fold drag errors.

Gradient parameter and axial and field rays in the gradient-index crystalline lens model

NASA Astrophysics Data System (ADS)

Pérez, M. V.; Bao, C.; Flores-Arias, M. T.; Rama, M. A.; Gómez-Reino, C.

2003-09-01

Gradient-index models of the human lens have received wide attention in optometry and vision sciences for considering how changes in the refractive index profile with age and accommodation may affect refractive power. This paper uses the continuous asymmetric bi-elliptical model to determine gradient parameter and axial and field rays of the human lens in order to study the paraxial propagation of light through the crystalline lens of the eye.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chrystal, C.; Grierson, B. A.; Staebler, G. M.

Here, experiments at the DIII-D tokamak have used dimensionless parameter scans to investigate the dependencies of intrinsic torque and momentum transport in order to inform a prediction of the rotation profile in ITER. Measurements of intrinsic torque profiles and momentum confinement time in dimensionless parameter scans of normalized gyroradius and collisionality are used to predict the amount of intrinsic rotation in the pedestal of ITER. Additional scans of T e/T i and safety factor are used to determine the accuracy of momentum flux predictions of the quasi-linear gyrokinetic code TGLF. In these scans, applications of modulated torque are used tomore » measure the incremental momentum diffusivity, and results are consistent with the E x B shear suppression of turbulent transport. These incremental transport measurements are also compared with the TGLF results. In order to form a prediction of the rotation profile for ITER, the pedestal prediction is used as a boundary condition to a simulation that uses TGLF to determine the transport in the core of the plasma. The predicted rotation is ≈20 krad/s in the core, lower than in many current tokamak operating scenarios. TGLF predictions show that this rotation is still significant enough to have a strong effect on confinement via E x B shear.« less

Predicting rotation for ITER via studies of intrinsic torque and momentum transport in DIII-D

DOE PAGES

Chrystal, C.; Grierson, B. A.; Staebler, G. M.; ...

2017-03-30

Here, experiments at the DIII-D tokamak have used dimensionless parameter scans to investigate the dependencies of intrinsic torque and momentum transport in order to inform a prediction of the rotation profile in ITER. Measurements of intrinsic torque profiles and momentum confinement time in dimensionless parameter scans of normalized gyroradius and collisionality are used to predict the amount of intrinsic rotation in the pedestal of ITER. Additional scans of T e/T i and safety factor are used to determine the accuracy of momentum flux predictions of the quasi-linear gyrokinetic code TGLF. In these scans, applications of modulated torque are used tomore » measure the incremental momentum diffusivity, and results are consistent with the E x B shear suppression of turbulent transport. These incremental transport measurements are also compared with the TGLF results. In order to form a prediction of the rotation profile for ITER, the pedestal prediction is used as a boundary condition to a simulation that uses TGLF to determine the transport in the core of the plasma. The predicted rotation is ≈20 krad/s in the core, lower than in many current tokamak operating scenarios. TGLF predictions show that this rotation is still significant enough to have a strong effect on confinement via E x B shear.« less

Magnetohydrodynamic Flow by a Stretching Cylinder with Newtonian Heating and Homogeneous-Heterogeneous Reactions

PubMed Central

Hayat, T.; Hussain, Zakir; Alsaedi, A.; Farooq, M.

2016-01-01

This article examines the effects of homogeneous-heterogeneous reactions and Newtonian heating in magnetohydrodynamic (MHD) flow of Powell-Eyring fluid by a stretching cylinder. The nonlinear partial differential equations of momentum, energy and concentration are reduced to the nonlinear ordinary differential equations. Convergent solutions of momentum, energy and reaction equations are developed by using homotopy analysis method (HAM). This method is very efficient for development of series solutions of highly nonlinear differential equations. It does not depend on any small or large parameter like the other methods i. e., perturbation method, δ—perturbation expansion method etc. We get more accurate result as we increase the order of approximations. Effects of different parameters on the velocity, temperature and concentration distributions are sketched and discussed. Comparison of present study with the previous published work is also made in the limiting sense. Numerical values of skin friction coefficient and Nusselt number are also computed and analyzed. It is noticed that the flow accelerates for large values of Powell-Eyring fluid parameter. Further temperature profile decreases and concentration profile increases when Powell-Eyring fluid parameter enhances. Concentration distribution is decreasing function of homogeneous reaction parameter while opposite influence of heterogeneous reaction parameter appears. PMID:27280883

Magnetohydrodynamic Flow by a Stretching Cylinder with Newtonian Heating and Homogeneous-Heterogeneous Reactions.

PubMed

Hayat, T; Hussain, Zakir; Alsaedi, A; Farooq, M

2016-01-01

This article examines the effects of homogeneous-heterogeneous reactions and Newtonian heating in magnetohydrodynamic (MHD) flow of Powell-Eyring fluid by a stretching cylinder. The nonlinear partial differential equations of momentum, energy and concentration are reduced to the nonlinear ordinary differential equations. Convergent solutions of momentum, energy and reaction equations are developed by using homotopy analysis method (HAM). This method is very efficient for development of series solutions of highly nonlinear differential equations. It does not depend on any small or large parameter like the other methods i. e., perturbation method, δ-perturbation expansion method etc. We get more accurate result as we increase the order of approximations. Effects of different parameters on the velocity, temperature and concentration distributions are sketched and discussed. Comparison of present study with the previous published work is also made in the limiting sense. Numerical values of skin friction coefficient and Nusselt number are also computed and analyzed. It is noticed that the flow accelerates for large values of Powell-Eyring fluid parameter. Further temperature profile decreases and concentration profile increases when Powell-Eyring fluid parameter enhances. Concentration distribution is decreasing function of homogeneous reaction parameter while opposite influence of heterogeneous reaction parameter appears.

Mean field study of a propagation-turnover lattice model for the dynamics of histone marking

NASA Astrophysics Data System (ADS)

Yao, Fan; Li, FangTing; Li, TieJun

2017-02-01

We present a mean field study of a propagation-turnover lattice model, which was proposed by Hodges and Crabtree [Proc. Nat. Acad. Sci. 109, 13296 (2012)] for understanding how posttranslational histone marks modulate gene expression in mammalian cells. The kinetics of the lattice model consists of nucleation, propagation and turnover mechanisms, and exhibits second-order phase transition for the histone marking domain. We showed rigorously that the dynamics essentially depends on a non-dimensional parameter κ = k +/ k -, the ratio between the propagation and turnover rates, which has been observed in the simulations. We then studied the lowest order mean field approximation, and observed the phase transition with an analytically obtained critical parameter. The boundary layer analysis was utilized to investigate the structure of the decay profile of the mark density. We also studied the higher order mean field approximation to achieve sharper estimate of the critical transition parameter and more detailed features. The comparison between the simulation and theoretical results shows the validity of our theory.

Volumetrical Characterization of Sheet Molding Compounds

PubMed Central

Calvimontes, Alfredo; Grundke, Karina; Müller, Anett

2010-01-01

For a comprehensive study of Sheet Molding Compound (SMC) surfaces, topographical data obtained by chromatic confocal imaging were submitted systematically for the development of a profile model to understand the formation of cavities on the surface. In order to qualify SMC surfaces and to predict their coatability, a characterization of cavities is applied. To quantify the effect of surface modification treatments, a new parameter (Surface Relative Smooth) is presented, applied and probed. The parameter proposed can be used for any surface modification of any solid material. PMID:28883370

A Boussinesq-scaled, pressure-Poisson water wave model

NASA Astrophysics Data System (ADS)

Donahue, Aaron S.; Zhang, Yao; Kennedy, Andrew B.; Westerink, Joannes J.; Panda, Nishant; Dawson, Clint

2015-02-01

Through the use of Boussinesq scaling we develop and test a model for resolving non-hydrostatic pressure profiles in nonlinear wave systems over varying bathymetry. A Green-Nagdhi type polynomial expansion is used to resolve the pressure profile along the vertical axis, this is then inserted into the pressure-Poisson equation, retaining terms up to a prescribed order and solved using a weighted residual approach. The model shows rapid convergence properties with increasing order of polynomial expansion which can be greatly improved through the application of asymptotic rearrangement. Models of Boussinesq scaling of the fully nonlinear O (μ2) and weakly nonlinear O (μN) are presented, the analytical and numerical properties of O (μ2) and O (μ4) models are discussed. Optimal basis functions in the Green-Nagdhi expansion are determined through manipulation of the free-parameters which arise due to the Boussinesq scaling. The optimal O (μ2) model has dispersion accuracy equivalent to a Padé [2,2] approximation with one extra free-parameter. The optimal O (μ4) model obtains dispersion accuracy equivalent to a Padé [4,4] approximation with two free-parameters which can be used to optimize shoaling or nonlinear properties. In comparison to experimental results the O (μ4) model shows excellent agreement to experimental data.

Sensitivity Analysis of Cf-252 (sf) Neutron and Gamma Observables in CGMF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, Austin Lewis; Talou, Patrick; Stetcu, Ionel

CGMF is a Monte Carlo code that simulates the decay of primary fission fragments by emission of neutrons and gamma rays, according to the Hauser-Feshbach equations. As the CGMF code was recently integrated into the MCNP6.2 transport code, great emphasis has been placed on providing optimal parameters to CGMF such that many different observables are accurately represented. Of these observables, the prompt neutron spectrum, prompt neutron multiplicity, prompt gamma spectrum, and prompt gamma multiplicity are crucial for accurate transport simulations of criticality and nonproliferation applications. This contribution to the ongoing efforts to improve CGMF presents a study of the sensitivitymore » of various neutron and gamma observables to several input parameters for Californium-252 spontaneous fission. Among the most influential parameters are those that affect the input yield distributions in fragment mass and total kinetic energy (TKE). A new scheme for representing Y(A,TKE) was implemented in CGMF using three fission modes, S1, S2 and SL. The sensitivity profiles were calculated for 17 total parameters, which show that the neutron multiplicity distribution is strongly affected by the TKE distribution of the fragments. The total excitation energy (TXE) of the fragments is shared according to a parameter RT, which is defined as the ratio of the light to heavy initial temperatures. The sensitivity profile of the neutron multiplicity shows a second order effect of RT on the mean neutron multiplicity. A final sensitivity profile was produced for the parameter alpha, which affects the spin of the fragments. Higher values of alpha lead to higher fragment spins, which inhibit the emission of neutrons. Understanding the sensitivity of the prompt neutron and gamma observables to the many CGMF input parameters provides a platform for the optimization of these parameters.« less

Anaerobic biodegradability of fish remains: experimental investigation and parameter estimation.

PubMed

Donoso-Bravo, Andres; Bindels, Francoise; Gerin, Patrick A; Vande Wouwer, Alain

2015-01-01

The generation of organic waste associated with aquaculture fish processing has increased significantly in recent decades. The objective of this study is to evaluate the anaerobic biodegradability of several fish processing fractions, as well as water treatment sludge, for tilapia and sturgeon species cultured in recirculated aquaculture systems. After substrate characterization, the ultimate biodegradability and the hydrolytic rate were estimated by fitting a first-order kinetic model with the biogas production profiles. In general, the first-order model was able to reproduce the biogas profiles properly with a high correlation coefficient. In the case of tilapia, the skin/fin, viscera, head and flesh presented a high level of biodegradability, above 310 mLCH₄gCOD⁻¹, whereas the head and bones showed a low hydrolytic rate. For sturgeon, the results for all fractions were quite similar in terms of both parameters, although viscera presented the lowest values. Both the substrate characterization and the kinetic analysis of the anaerobic degradation may be used as design criteria for implementing anaerobic digestion in a recirculating aquaculture system.

Miniregoliths. I - Dusty lunar rocks and lunar soil layers

NASA Technical Reports Server (NTRS)

Comstock, G. M.

1978-01-01

A detailed Monte-Carlo model for rock surface evolution shows that erosion processes alone cannot account for the shapes of the solar flare particle track profiles generally observed at depths of about 100 microns and less in rocks. The observed profiles are easily explained by a steady accumulation of fine dust at a rate of 0.3 to 3 mm per m.y., depending on the micrometeoroid impact rate which controls the dust cover and results in maximum dust thicknesses on the order of 100 microns to 1 mm. The commonly used lunar soil track parameters are derived in terms of parameters characterizing the exposure of soil grains in the few-millimeter-thick surface mixing and maturation zone which is one form of miniregolith. Correlation plots permit determining the degree of mixing in soil samples and the amount of processing (maturation) in surface miniregoliths. It is shown that the sampling process often artificially mixes together finer distinct layers, and that ancient miniregolith layers on the order of a millimeter thick are probably common in the lunar soil.

Causal dissipation and shock profiles in the relativistic fluid dynamics of pure radiation.

PubMed

Freistühler, Heinrich; Temple, Blake

2014-06-08

CURRENT THEORIES OF DISSIPATION IN THE RELATIVISTIC REGIME SUFFER FROM ONE OF TWO DEFICITS: either their dissipation is not causal or no profiles for strong shock waves exist. This paper proposes a relativistic Navier-Stokes-Fourier-type viscosity and heat conduction tensor such that the resulting second-order system of partial differential equations for the fluid dynamics of pure radiation is symmetric hyperbolic. This system has causal dissipation as well as the property that all shock waves of arbitrary strength have smooth profiles. Entropy production is positive both on gradients near those of solutions to the dissipation-free equations and on gradients of shock profiles. This shows that the new dissipation stress tensor complies to leading order with the principles of thermodynamics. Whether higher order modifications of the ansatz are required to obtain full compatibility with the second law far from the zero-dissipation equilibrium is left to further investigations. The system has exactly three a priori free parameters χ , η , ζ , corresponding physically to heat conductivity, shear viscosity and bulk viscosity. If the bulk viscosity is zero (as is stated in the literature) and the total stress-energy tensor is trace free, the entire viscosity and heat conduction tensor is determined to within a constant factor.

Causal dissipation and shock profiles in the relativistic fluid dynamics of pure radiation

PubMed Central

Freistühler, Heinrich; Temple, Blake

2014-01-01

Current theories of dissipation in the relativistic regime suffer from one of two deficits: either their dissipation is not causal or no profiles for strong shock waves exist. This paper proposes a relativistic Navier–Stokes–Fourier-type viscosity and heat conduction tensor such that the resulting second-order system of partial differential equations for the fluid dynamics of pure radiation is symmetric hyperbolic. This system has causal dissipation as well as the property that all shock waves of arbitrary strength have smooth profiles. Entropy production is positive both on gradients near those of solutions to the dissipation-free equations and on gradients of shock profiles. This shows that the new dissipation stress tensor complies to leading order with the principles of thermodynamics. Whether higher order modifications of the ansatz are required to obtain full compatibility with the second law far from the zero-dissipation equilibrium is left to further investigations. The system has exactly three a priori free parameters χ,η,ζ, corresponding physically to heat conductivity, shear viscosity and bulk viscosity. If the bulk viscosity is zero (as is stated in the literature) and the total stress–energy tensor is trace free, the entire viscosity and heat conduction tensor is determined to within a constant factor. PMID:24910526

Local Neutral Density and Plasma Parameter Measurements in a Hollow Cathode Plume

NASA Technical Reports Server (NTRS)

Jameson, Kristina K.; Goebel, Dan M.; MiKellides, Joannis; Watkins, Ron M.

2006-01-01

In order to understand the cathode and keeper wear observed during the Extended Life Test (ELT) of the DS1 flight spare NSTAR thruster and provide benchmarking data for a 2D cathode/cathode-plume model, a basic understanding of the plasma and neutral gas parameters in the cathode orifice and keeper region of the cathode plume must be obtained. The JPL cathode facility is instrumented with an array of Langmuir probe diagnostics along with an optical diagnostic to measure line intensity of xenon neutrals. In order to make direct comparisons with the present model, a flat plate anode arrangement was installed for these tests. Neutral density is deduced from the scanning probe data of the plasma parameters and the measured xenon line intensity in the optical regime. The Langmuir probes are scanned both axially, out to 7.0 cm downstream of the keeper, and radially to obtain 2D profile of the plasma parameters. The optical fiber is housed in a collimating stainless steel tube, and is scanned to view across the cathode plume along cuts in front of the keeper with a resolution of 1.5 mm. The radial intensities are unfolded using the Abel inversion technique that produces radial profiles of local neutral density. In this paper, detailed measurements of the plasma parameters and the local neutral densities will be presented in the cathode/keeper plume region for a 1.5 cm diameter NEXIS cathode at 25A of discharge current at several different strengths of applied magnetic field.

Atmospheric, Cloud, and Surface Parameters Retrieved from Satellite Ultra-spectral Infrared Sounder Measurements

NASA Technical Reports Server (NTRS)

Zhou, Daniel K.; Liu, Xu; Larar, Allen M.; Smith, William L.; Yang, Ping; Schluessel, Peter; Strow, Larrabee

2007-01-01

An advanced retrieval algorithm with a fast radiative transfer model, including cloud effects, is used for atmospheric profile and cloud parameter retrieval. This physical inversion scheme has been developed, dealing with cloudy as well as cloud-free radiance observed with ultraspectral infrared sounders, to simultaneously retrieve surface, atmospheric thermodynamic, and cloud microphysical parameters. A fast radiative transfer model, which applies to the clouded atmosphere, is used for atmospheric profile and cloud parameter retrieval. A one-dimensional (1-d) variational multivariable inversion solution is used to improve an iterative background state defined by an eigenvector-regression-retrieval. The solution is iterated in order to account for non-linearity in the 1-d variational solution. This retrieval algorithm is applied to the MetOp satellite Infrared Atmospheric Sounding Interferometer (IASI) launched on October 19, 2006. IASI possesses an ultra-spectral resolution of 0.25 cm(exp -1) and a spectral coverage from 645 to 2760 cm(exp -1). Preliminary retrievals of atmospheric soundings, surface properties, and cloud optical/microphysical properties with the IASI measurements are obtained and presented.

A physics-based fractional order model and state of energy estimation for lithium ion batteries. Part II: Parameter identification and state of energy estimation for LiFePO4 battery

NASA Astrophysics Data System (ADS)

Li, Xiaoyu; Pan, Ke; Fan, Guodong; Lu, Rengui; Zhu, Chunbo; Rizzoni, Giorgio; Canova, Marcello

2017-11-01

State of energy (SOE) is an important index for the electrochemical energy storage system in electric vehicles. In this paper, a robust state of energy estimation method in combination with a physical model parameter identification method is proposed to achieve accurate battery state estimation at different operating conditions and different aging stages. A physics-based fractional order model with variable solid-state diffusivity (FOM-VSSD) is used to characterize the dynamic performance of a LiFePO4/graphite battery. In order to update the model parameter automatically at different aging stages, a multi-step model parameter identification method based on the lexicographic optimization is especially designed for the electric vehicle operating conditions. As the battery available energy changes with different applied load current profiles, the relationship between the remaining energy loss and the state of charge, the average current as well as the average squared current is modeled. The SOE with different operating conditions and different aging stages are estimated based on an adaptive fractional order extended Kalman filter (AFEKF). Validation results show that the overall SOE estimation error is within ±5%. The proposed method is suitable for the electric vehicle online applications.

Measurement of the spatial distribution of atmospheric turbulence with SCINDAR on a mosaic of urban surfaces

NASA Astrophysics Data System (ADS)

Nguyen, K.-L.; Robert, C.; Conan, J.-M.; Mugnier, L. M.; Cohard, J.-M.; Irvine, M.; Lagouarde, J.-P.

2017-09-01

Two experiments of urban scintillometry were performed recently. Their objective was to study the SCINDAR Cn² profiler performance on a composite urbanforest ground. The SCINDAR provides horizontal Cn² profiles with a few hundred meter profile resolution. Several improvements in data processing are reported: the choice of the spatial resolution of the profile and the hyper-parameters adjustment for Cn² regularization. The distributed Cn² values along the optical path are estimated every minute with small error bars. Their non-uniformity is shown to be consistent with the differences of the line of sight to ground and the coverage of the terrain. The SCINDAR data are also in the same order of magnitude with the three scintillometer data that were simultaneously recorded.

Retrieval method of aerosol extinction coefficient profile by an integral lidar system and case study

NASA Astrophysics Data System (ADS)

Shan, Huihui; Zhang, Hui; Liu, Junjian; Wang, Shenhao; Ma, Xiaomin; Zhang, Lianqing; Liu, Dong; Xie, Chenbo; Tao, Zongming

2018-02-01

Aerosol extinction coefficient profile is an essential parameter for atmospheric radiation model. But it is difficult to get the full aerosol extinction profile from the ground to the tropopause especially in near ground precisely using backscattering lidar. A combined measurement of side-scattering, backscattering and Raman-scattering lidar is proposed to retrieve the aerosol extinction coefficient profile from the surface to the tropopause which covered a dynamic range of 5 orders. The side-scattering technique solves the dead zone and the overlap problem caused by the traditional lidar in the near range. Using the Raman-scattering the aerosol lidar ratio (extinction to backscatter ratio) can be obtained. The cases studies in this paper show the proposed method is reasonable and feasible.

Analytical modeling and tolerance analysis of a linear variable filter for spectral order sorting.

PubMed

Ko, Cheng-Hao; Chang, Kuei-Ying; Huang, You-Min

2015-02-23

This paper proposes an innovative method to overcome the low production rate of current linear variable filter (LVF) fabrication. During the fabrication process, a commercial coater is combined with a local mask on a substrate. The proposed analytical thin film thickness model, which is based on the geometry of the commercial coater, is developed to more effectively calculate the profiles of LVFs. Thickness tolerance, LVF zone width, thin film layer structure, transmission spectrum and the effects of variations in critical parameters of the coater are analyzed. Profile measurements demonstrate the efficacy of local mask theory in the prediction of evaporation profiles with a high degree of accuracy.

Gaussian beam profile shaping apparatus, method therefor and evaluation thereof

DOEpatents

Dickey, Fred M.; Holswade, Scott C.; Romero, Louis A.

1999-01-01

A method and apparatus maps a Gaussian beam into a beam with a uniform irradiance profile by exploiting the Fourier transform properties of lenses. A phase element imparts a design phase onto an input beam and the output optical field from a lens is then the Fourier transform of the input beam and the phase function from the phase element. The phase element is selected in accordance with a dimensionless parameter which is dependent upon the radius of the incoming beam, the desired spot shape, the focal length of the lens and the wavelength of the input beam. This dimensionless parameter can also be used to evaluate the quality of a system. In order to control the radius of the incoming beam, optics such as a telescope can be employed. The size of the target spot and the focal length can be altered by exchanging the transform lens, but the dimensionless parameter will remain the same. The quality of the system, and hence the value of the dimensionless parameter, can be altered by exchanging the phase element. The dimensionless parameter provides design guidance, system evaluation, and indication as to how to improve a given system.

Gaussian beam profile shaping apparatus, method therefore and evaluation thereof

DOEpatents

Dickey, F.M.; Holswade, S.C.; Romero, L.A.

1999-01-26

A method and apparatus maps a Gaussian beam into a beam with a uniform irradiance profile by exploiting the Fourier transform properties of lenses. A phase element imparts a design phase onto an input beam and the output optical field from a lens is then the Fourier transform of the input beam and the phase function from the phase element. The phase element is selected in accordance with a dimensionless parameter which is dependent upon the radius of the incoming beam, the desired spot shape, the focal length of the lens and the wavelength of the input beam. This dimensionless parameter can also be used to evaluate the quality of a system. In order to control the radius of the incoming beam, optics such as a telescope can be employed. The size of the target spot and the focal length can be altered by exchanging the transform lens, but the dimensionless parameter will remain the same. The quality of the system, and hence the value of the dimensionless parameter, can be altered by exchanging the phase element. The dimensionless parameter provides design guidance, system evaluation, and indication as to how to improve a given system. 27 figs.

Effect of thermal radiation and chemical reaction on non-Newtonian fluid through a vertically stretching porous plate with uniform suction

NASA Astrophysics Data System (ADS)

Khan, Zeeshan; Khan, Ilyas; Ullah, Murad; Tlili, I.

2018-06-01

In this work, we discuss the unsteady flow of non-Newtonian fluid with the properties of heat source/sink in the presence of thermal radiation moving through a binary mixture embedded in a porous medium. The basic equations of motion including continuity, momentum, energy and concentration are simplified and solved analytically by using Homotopy Analysis Method (HAM). The energy and concentration fields are coupled with Dankohler and Schmidt numbers. By applying suitable transformation, the coupled nonlinear partial differential equations are converted to couple ordinary differential equations. The effect of physical parameters involved in the solutions of velocity, temperature and concentration profiles are discussed by assign numerical values and results obtained shows that the velocity, temperature and concentration profiles are influenced appreciably by the radiation parameter, Prandtl number, suction/injection parameter, reaction order index, solutal Grashof number and the thermal Grashof. It is observed that the non-Newtonian parameter H leads to an increase in the boundary layer thickness. It was established that the Prandtl number decreases thee thermal boundary layer thickness which helps in maintaining system temperature of the fluid flow. It is observed that the temperature profiles higher for heat source parameter and lower for heat sink parameter throughout the boundary layer. Fromm this simulation it is analyzed that an increase in the Schmidt number decreases the concentration boundary layer thickness. Additionally, for the sake of comparison numerical method (ND-Solve) and Adomian Decomposition Method are also applied and good agreement is found.

Ionosphere Profile Estimation Using Ionosonde & GPS Data in an Inverse Refraction Calculation

NASA Astrophysics Data System (ADS)

Psiaki, M. L.

2014-12-01

A method has been developed to assimilate ionosonde virtual heights and GPS slant TEC data to estimate the parameters of a local ionosphere model, including estimates of the topside and of latitude and longitude variations. This effort seeks to better assimilate a variety of remote sensing data in order to characterize local (and eventually regional and global) ionosphere electron density profiles. The core calculations involve a forward refractive ray-tracing solution and a nonlinear optimal estimation algorithm that inverts the forward model. The ray-tracing calculations solve a nonlinear two-point boundary value problem for the curved ionosonde or GPS ray path through a parameterized electron density profile. It implements a full 3D solution that can handle the case of a tilted ionosphere. These calculations use Hamiltonian equivalents of the Appleton-Hartree magneto-plasma refraction index model. The current ionosphere parameterization is a modified Booker profile. It has been augmented to include latitude and longitude dependencies. The forward ray-tracing solution yields a given signal's group delay and beat carrier phase observables. An auxiliary set of boundary value problem solutions determine the sensitivities of the ray paths and observables with respect to the parameters of the augmented Booker profile. The nonlinear estimation algorithm compares the measured ionosonde virtual-altitude observables and GPS slant-TEC observables to the corresponding values from the forward refraction model. It uses the parameter sensitivities of the model to iteratively improve its parameter estimates in a way the reduces the residual errors between the measurements and their modeled values. This method has been applied to data from HAARP in Gakona, AK and has produced good TEC and virtual height fits. It has been extended to characterize electron density perturbations caused by HAARP heating experiments through the use of GPS slant TEC data for an LOS through the heated zone. The next planned extension of the method is to estimate the parameters of a regional ionosphere profile. The input observables will be slant TEC from an array of GPS receivers and group delay and carrier phase observables from an array of high-frequency beacons. The beacon array will function as a sort of multi-static ionosonde.

High-order sliding-mode control for blood glucose regulation in the presence of uncertain dynamics.

PubMed

Hernández, Ana Gabriela Gallardo; Fridman, Leonid; Leder, Ron; Andrade, Sergio Islas; Monsalve, Cristina Revilla; Shtessel, Yuri; Levant, Arie

2011-01-01

The success of blood glucose automatic regulation depends on the robustness of the control algorithm used. It is a difficult task to perform due to the complexity of the glucose-insulin regulation system. The variety of model existing reflects the great amount of phenomena involved in the process, and the inter-patient variability of the parameters represent another challenge. In this research a High-Order Sliding-Mode Control is proposed. It is applied to two well known models, Bergman Minimal Model, and Sorensen Model, to test its robustness with respect to uncertain dynamics, and patients' parameter variability. The controller designed based on the simulations is tested with the specific Bergman Minimal Model of a diabetic patient whose parameters were identified from an in vivo assay. To minimize the insulin infusion rate, and avoid the hypoglycemia risk, the glucose target is a dynamical profile.

Observation of High-Order Polarization-Locked Vector Solitons in a Fiber Laser

NASA Astrophysics Data System (ADS)

Tang, D. Y.; Zhang, H.; Zhao, L. M.; Wu, X.

2008-10-01

We report on the experimental observation of a new type of polarization-locked vector soliton in a passively mode-locked fiber laser. The vector soliton is characterized by the fact that not only are the two orthogonally polarized soliton components phase-locked, but also one of the components has a double-humped intensity profile. Multiple phase-locked high-order vector solitons with identical soliton parameters and harmonic mode locking of the vector solitons were also obtained in the laser. Numerical simulations confirmed the existence of stable high-order vector solitons in the fiber laser.

Observation of high-order polarization-locked vector solitons in a fiber laser.

PubMed

Tang, D Y; Zhang, H; Zhao, L M; Wu, X

2008-10-10

We report on the experimental observation of a new type of polarization-locked vector soliton in a passively mode-locked fiber laser. The vector soliton is characterized by the fact that not only are the two orthogonally polarized soliton components phase-locked, but also one of the components has a double-humped intensity profile. Multiple phase-locked high-order vector solitons with identical soliton parameters and harmonic mode locking of the vector solitons were also obtained in the laser. Numerical simulations confirmed the existence of stable high-order vector solitons in the fiber laser.

A high resolution hand-held focused beam profiler

NASA Astrophysics Data System (ADS)

Zapata-Farfan, J.; Garduño-Mejía, J.; Rosete-Aguilar, M.; Ascanio, G.; Román-Moreno, C. J.

2017-05-01

The shape of a beam is important in any laser application and depending on the final implementation, there exists a preferred one which is defined by the irradiance distribution.1 The energy distribution (or laser beam profile) is an important parameter in a focused beam, for instance, in laser cut industry, where the beam shape determines the quality of the cut. In terms of alignment and focusing, the energy distribution also plays an important role since the system must be configured in order to reduce the aberration effects and achieve the highest intensity. Nowadays a beam profiler is used in both industry and research laboratories with the aim to characterize laser beams used in free-space communications, focusing and welding, among other systems. The purpose of the profile analyzers is to know the main parameters of the beam, to control its characteristics as uniformity, shape and beam size as a guide to align the focusing system. In this work is presented a high resolution hand-held and compact design of a beam profiler capable to measure at the focal plane, with covered range from 400 nm to 1000 nm. The detection is reached with a CMOS sensor sized in 3673.6 μm x 2738.4 μm which acquire a snap shot of the previously attenuated focused beam to avoid the sensor damage, the result is an image of beam intensity distribution, which is digitally processed with a RaspberryTMmodule gathering significant parameters such as beam waist, centroid, uniformity and also some aberrations. The profiler resolution is 1.4 μm and was probed and validated in three different focusing systems. The spot sizes measurements were compared with the Foucault knife-edge test.

Implementation and Performance Evaluation of Parameter Improvement Mechanisms for Intelligent E-Learning Systems

ERIC Educational Resources Information Center

Huang, Chenn-Jung; Chu, San-Shine; Guan, Chih-Tai

2007-01-01

In recent years, designing useful learning diagnosis systems has become a hot research topic in the literature. In order to help teachers easily analyze students' profiles in intelligent tutoring system, it is essential that students' portfolios can be transformed into some useful information to reflect the extent of students' participation in the…

A gradient-based model parametrization using Bernstein polynomials in Bayesian inversion of surface wave dispersion

NASA Astrophysics Data System (ADS)

Gosselin, Jeremy M.; Dosso, Stan E.; Cassidy, John F.; Quijano, Jorge E.; Molnar, Sheri; Dettmer, Jan

2017-10-01

This paper develops and applies a Bernstein-polynomial parametrization to efficiently represent general, gradient-based profiles in nonlinear geophysical inversion, with application to ambient-noise Rayleigh-wave dispersion data. Bernstein polynomials provide a stable parametrization in that small perturbations to the model parameters (basis-function coefficients) result in only small perturbations to the geophysical parameter profile. A fully nonlinear Bayesian inversion methodology is applied to estimate shear wave velocity (VS) profiles and uncertainties from surface wave dispersion data extracted from ambient seismic noise. The Bayesian information criterion is used to determine the appropriate polynomial order consistent with the resolving power of the data. Data error correlations are accounted for in the inversion using a parametric autoregressive model. The inversion solution is defined in terms of marginal posterior probability profiles for VS as a function of depth, estimated using Metropolis-Hastings sampling with parallel tempering. This methodology is applied to synthetic dispersion data as well as data processed from passive array recordings collected on the Fraser River Delta in British Columbia, Canada. Results from this work are in good agreement with previous studies, as well as with co-located invasive measurements. The approach considered here is better suited than `layered' modelling approaches in applications where smooth gradients in geophysical parameters are expected, such as soil/sediment profiles. Further, the Bernstein polynomial representation is more general than smooth models based on a fixed choice of gradient type (e.g. power-law gradient) because the form of the gradient is determined objectively by the data, rather than by a subjective parametrization choice.

Modulational instability and higher-order rogue waves with parameters modulation in a coupled integrable AB system via the generalized Darboux transformation.

PubMed

Wen, Xiao-Yong; Yan, Zhenya

2015-12-01

We study higher-order rogue wave (RW) solutions of the coupled integrable dispersive AB system (also called Pedlosky system), which describes the evolution of wave-packets in a marginally stable or unstable baroclinic shear flow in geophysical fluids. We propose its continuous-wave (CW) solutions and existent conditions for their modulation instability to form the rogue waves. A new generalized N-fold Darboux transformation (DT) is proposed in terms of the Taylor series expansion for the spectral parameter in the Darboux matrix and its limit procedure and applied to the CW solutions to generate multi-rogue wave solutions of the coupled AB system, which satisfy the general compatibility condition. The dynamical behaviors of these higher-order rogue wave solutions demonstrate both strong and weak interactions by modulating parameters, in which some weak interactions can generate the abundant triangle, pentagon structures, etc. Particularly, the trajectories of motion of peaks and depressions of profiles of the first-order RWs are explicitly analyzed. The generalized DT method used in this paper can be extended to other nonlinear integrable systems. These results may be useful for understanding the corresponding rogue-wave phenomena in fluid mechanics and related fields.

Higher-order rational solitons and rogue-like wave solutions of the (2 + 1)-dimensional nonlinear fluid mechanics equations

NASA Astrophysics Data System (ADS)

Wen, Xiao-Yong; Yan, Zhenya

2017-02-01

The novel generalized perturbation (n, M)-fold Darboux transformations (DTs) are reported for the (2 + 1)-dimensional Kadomtsev-Petviashvili (KP) equation and its extension by using the Taylor expansion of the Darboux matrix. The generalized perturbation (1 , N - 1) -fold DTs are used to find their higher-order rational solitons and rogue wave solutions in terms of determinants. The dynamics behaviors of these rogue waves are discussed in detail for different parameters and time, which display the interesting RW and soliton structures including the triangle, pentagon, heptagon profiles, etc. Moreover, we find that a new phenomenon that the parameter (a) can control the wave structures of the KP equation from the higher-order rogue waves (a ≠ 0) into higher-order rational solitons (a = 0) in (x, t)-space with y = const . These results may predict the corresponding dynamical phenomena in the models of fluid mechanics and other physically relevant systems.

Soliton solutions to the fifth-order Korteweg-de Vries equation and their applications to surface and internal water waves

NASA Astrophysics Data System (ADS)

Khusnutdinova, K. R.; Stepanyants, Y. A.; Tranter, M. R.

2018-02-01

We study solitary wave solutions of the fifth-order Korteweg-de Vries equation which contains, besides the traditional quadratic nonlinearity and third-order dispersion, additional terms including cubic nonlinearity and fifth order linear dispersion, as well as two nonlinear dispersive terms. An exact solitary wave solution to this equation is derived, and the dependence of its amplitude, width, and speed on the parameters of the governing equation is studied. It is shown that the derived solution can represent either an embedded or regular soliton depending on the equation parameters. The nonlinear dispersive terms can drastically influence the existence of solitary waves, their nature (regular or embedded), profile, polarity, and stability with respect to small perturbations. We show, in particular, that in some cases embedded solitons can be stable even with respect to interactions with regular solitons. The results obtained are applicable to surface and internal waves in fluids, as well as to waves in other media (plasma, solid waveguides, elastic media with microstructure, etc.).

Order and anarchy hand in hand in 5D SO(10)

NASA Astrophysics Data System (ADS)

Vicino, D.

2015-07-01

A mechanism to generate flavour hierarchy via 5D wave-function localization is revisited in the context of SO(10) grand unified theory. In an extra-dimension compactified on an orbifold, fermions (living in the same 16 representation of SO(10)) result having exponential zero-modes profiles, localized around one of the brane. The breaking of SO(10) down to SU(5) × U(1)x provides the key parameter that distinguishes the profiles of the different SU(5) components inside the same 16 representation. Utilizing a suitable set of scalar fields, a predictive model for fermion masses and mixing is constructed and shown to be viable with the current data through a detailed numerical analysis. The scalar field content of the model is also suitable to solve the doublet-triplet splitting problem through the missing partner mechanism. All the Yukawa couplings in the model are anarchical and of order unity, while the hierarchies among different fermions result only from zero-mode profiles. The naturalness of Anarchical Yukawa couplings is studied, showing a preference for a normal ordered neutrino spectrum; predictions for various observables in the lepton sector are also derived.

Analytical solutions to the problem of transient heat transfer in living tissue.

NASA Technical Reports Server (NTRS)

Shitzer, A.; Chato, J. C.

1971-01-01

An analytical model of transient heat transfer in living biological tissue is considered. The model includes storage, generation, conduction, and convective transport of heat in the tissue. Solutions for rectangular and cylindrical coordinates are presented and discussed. Transient times for reaching the ?locally fully developed' temperature profile were found to be of the order of 5 to 25 min. These transients are dominated by a geometrical parameters and, to a lesser extent, by a parameter representing the ratio of heat supplied by blood flow to heat conducted in the tissue.

Influence of polymer network parameters of tragacanth gum-based pH responsive hydrogels on drug delivery.

PubMed

Singh, Baljit; Sharma, Vikrant

2014-01-30

The present article deals with design of tragacanth gum-based pH responsive hydrogel drug delivery systems. The characterization of hydrogels has been carried out by SEMs, EDAX, FTIR, (13)C NMR, XRD, TGA/DTA/DTG and swelling studies. The correlation between reaction conditions and structural parameters of polymer networks such as polymer volume fraction in the swollen state (ϕ), Flory-Huggins interaction parameter (χ), molecular weight of the polymer chain between two neighboring cross links (M¯c), crosslink density (ρ) and mesh size (ξ) has been determined. The different kinetic models such as zero order, first order, Higuchi square root law, Korsmeyer-Peppas model and Hixson-Crowell cube root model were applied and it has been observed that release profile of amoxicillin best followed the first order model for the release of drug from the polymer matrix. The swelling of the hydrogels and release of drug from the drug loaded hydrogels occurred through non-Fickian diffusion mechanism in pH 7.4 solution. Copyright © 2013 Elsevier Ltd. All rights reserved.

Two healing lengths in a two-band GL-model with quadratic terms: Numerical results

NASA Astrophysics Data System (ADS)

Macias-Medri, A. E.; Rodríguez-Núñez, J. J.

2018-05-01

A two-band and quartic interaction order Ginzburg-Landau model in the presence of a single vortex is studied in this work. Interactions of second (quadratic, with coupling parameter γ) and fourth (quartic, with coupling parameter γ˜) order between the two superconducting order parameters (fi with i = 1,2) are incorporated in a functional. Terms beyond quadratic gradient contributions are neglected in the corresponding minimized free energy. The solution of the system of coupled equations is solved by numerical methods to obtain the fi-profiles, where our starting point was the calculation of the superconducting critical temperature Tc. With this at hand, we evaluate fi and the magnetic field along the z-axis, B0, as function of γ, γ˜, the radial distance r/λ1(0) and the temperature T, for T ≈ Tc. The self-consistent equations allow us to compute λ (penetration depth) and the healing lengths of fi (Lhi with i = 1,2) as functions of T, γ and γ˜. At the end, relevant discussions about type-1.5 superconductivity in the compounds we have studied are presented.

A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens

PubMed Central

Wu, Jun Jie; Wu, Weiju; Tholozan, Frederique M.; Saunter, Christopher D.; Girkin, John M.; Quinlan, Roy A.

2015-01-01

We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species comparisons where lens sizes can vary greatly (e.g. bovine (approx. 18 mm); mouse (approx. 2 mm)) and confirms that mammalian lenses scale with size. The validated model includes two parameters: β/α, which is the ratio of the proliferation rate in the peripheral and in the central region of the lens; and γGZ, a dimensionless pull-through parameter that accounts for the cell transition and exit from the epithelium into the lens body. Best-fit values were determined for mouse, rat, rabbit, bovine and human lens epithelia. The OPT model accounts for the peak in cell density at the periphery of the lens epithelium, a region where cell proliferation is concentrated and reaches a maximum coincident with the germinative zone. The β/α ratio correlates with the measured FGF-2 gradient, a morphogen critical to lens cell survival, proliferation and differentiation. As proliferation declines with age, the OPT model predicted age-dependent changes in cell-density profiles, which we observed in mouse and human lenses. PMID:26236824

Noise Whitening in Airborne Wind Profiling With a Pulsed 2-Micron Coherent Doppler Lidar at NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Beyon, Jeffrey Y.; Arthur, Grant E.; Koch, Grady J.; Kavaya, Michael J.

2012-01-01

Two different noise whitening methods in airborne wind profiling with a pulsed 2-micron coherent Doppler lidar system at NASA Langley Research Center in Virginia are presented. In order to provide accurate wind parameter estimates from the airborne lidar data acquired during the NASA Genesis and Rapid Intensification Processes (GRIP) campaign in 2010, the adverse effects of background instrument noise must be compensated properly in the early stage of data processing. The results of the two methods are presented using selected GRIP data and compared with the dropsonde data for verification purposes.

Deconvolution of complex differential scanning calorimetry profiles for protein transitions under kinetic control.

PubMed

Toledo-Núñez, Citlali; Vera-Robles, L Iraís; Arroyo-Maya, Izlia J; Hernández-Arana, Andrés

2016-09-15

A frequent outcome in differential scanning calorimetry (DSC) experiments carried out with large proteins is the irreversibility of the observed endothermic effects. In these cases, DSC profiles are analyzed according to methods developed for temperature-induced denaturation transitions occurring under kinetic control. In the one-step irreversible model (native → denatured) the characteristics of the observed single-peaked endotherm depend on the denaturation enthalpy and the temperature dependence of the reaction rate constant, k. Several procedures have been devised to obtain the parameters that determine the variation of k with temperature. Here, we have elaborated on one of these procedures in order to analyze more complex DSC profiles. Synthetic data for a heat capacity curve were generated according to a model with two sequential reactions; the temperature dependence of each of the two rate constants involved was determined, according to the Eyring's equation, by two fixed parameters. It was then shown that our deconvolution procedure, by making use of heat capacity data alone, permits to extract the parameter values that were initially used. Finally, experimental DSC traces showing two and three maxima were analyzed and reproduced with relative success according to two- and four-step sequential models. Copyright © 2016 Elsevier Inc. All rights reserved.

The role of emotions in spatial prisoner's dilemma game with voluntary participation

NASA Astrophysics Data System (ADS)

Wang, Lu; Ye, Shun-Qiang; Cheong, Kang Hao; Bao, Wei; Xie, Neng-gang

2018-01-01

This paper develops an extended emotional model in the voluntary prisoner's dilemma game. It fills a gap in the traditional imitation mechanism by assuming that players do not simply imitate pure strategies, but imitate the emotional profiles of one another instead. The relationship between emotional profiles and strategy are constructed and Monte Carlo simulations are performed on a square lattice. Simulation results reveal that with an increase in the temptation parameter T (1 ⩽ T ⩽ 2), the order-chaos-order transition occurs. When T is around 1.2, we find that a bifurcation occurs. From a social system perspective, as T increases, the system changes from a benign one (respect for the 'successful' people and sympathy towards the weak one) to one that is of vicious nature (that is, bully the weak and fear the strong).

Estimation of Mass-Loss Rates from Emission Line Profiles in the UV Spectra of Cool Stars

NASA Technical Reports Server (NTRS)

Carpenter, K. G.; Robinson, R. D.; Harper, G. M.

1999-01-01

The photon-scattering winds of cool, low-gravity stars (K-M giants and supergiants) produce absorption features in the strong chromospheric emission lines. This provides us with an opportunity to assess important parameters of the wind, including flow and turbulent velocities, the optical depth of the wind above the region of photon creation, and the star's mass-loss rate. We have used the Lamers et al. Sobolev with Exact Integration (SEI) radiative transfer code along with simple models of the outer atmospheric structure to compute synthetic line profiles for comparison with the observed line profiles. The SEI code has the advantage of being computationally fast and allows a great number of possible wind models to be examined. We therefore use it here to obtain initial first-order estimates of the wind parameters. More sophisticated, but more time-consuming and resource intensive calculations will be performed at a later date, using the SEI-deduced wind parameters as a starting point. A comparison of the profiles over a range of wind velocity laws, turbulence values, and line opacities allows us to constrain the wind parameters, and to estimate the mass-loss rates. We have applied this analysis technique (using lines of Mg II, 0 I, and Fe II) so far to four stars: the normal K5-giant alpha Tau, the hybrid K-giant gamma Dra, the K5 supergiant lambda Vel, and the M-giant gamma Cru. We present in this paper a description of the technique, including the assumptions which go into its use, an assessment of its robustness, and the results of our analysis.

Determining the vertical evolution of hydrodynamic parameters in weathered and fractured south Indian crystalline-rock aquifers: insights from a study on an instrumented site

NASA Astrophysics Data System (ADS)

Boisson, A.; Guihéneuf, N.; Perrin, J.; Bour, O.; Dewandel, B.; Dausse, A.; Viossanges, M.; Ahmed, S.; Maréchal, J. C.

2015-02-01

Due to extensive irrigation, most crystalline aquifers of south India are overexploited. Aquifer structure consists of an upper weathered saprolite followed by a fractured zone whose fracture density decreases with depth. To achieve sustainable management, the evolution of hydrodynamic parameters (transmissivity and storage coefficient) by depth in the south Indian context should be quantified. Falling-head borehole permeameter tests, injection tests, flowmeter profiles, single-packer tests and pumping tests were carried out in the unsaturated saprolite and saturated fractured granite. Results show that the saprolite is poorly transmissive (T fs = 3 × 10-7 to 8.5 × 10-8 m2 s-1) and that the most conductive part of the aquifer corresponds to the bottom of the saprolite and the upper part of the fractured rock (T = 1.0 × 10-3 to 7.0 × 10-4 m2 s-1). The transmissivity along the profile is mostly controlled by two distinct conductive zones without apparent vertical hydraulic connection. The transmissivity and storage coefficient both decrease with depth depending on the saturation of the main fracture zones, and boreholes are not exploitable after a certain depth (27.5 m on the investigated section). The numerous investigations performed allow a complete quantification with depth of the hydrodynamic parameters along the weathering profile, and a conceptual model is presented. Hydrograph observations (4 years) are shown to be relevant as a first-order characterization of the media and diffusivity evolution with depth. The evolution of these hydrodynamic parameters along the profile has a great impact on groundwater prospecting, exploitation and transport properties in such crystalline rock aquifers.

The multiuniverse transition in superfluid 3He

NASA Astrophysics Data System (ADS)

Bunkov, Yury

2013-10-01

The symmetry-breaking phase transitions of the universe and of superfluid 3He may lead to the formation of different states with different order parameters. In both cases the energy potential below the transition temperature has a complicated multidimensional profile with many local minima and saddle points, which correspond to different states. Consequently, not only topological defects, but also islands of different metastable states can be created. Using 3He we can analyse the properties and experimental consequences of such transitions and, in particular, the first-order phase transition between the two low symmetry states.

The multiuniverse transition in superfluid 3He.

PubMed

Bunkov, Yury

2013-10-09

The symmetry-breaking phase transitions of the universe and of superfluid (3)He may lead to the formation of different states with different order parameters. In both cases the energy potential below the transition temperature has a complicated multidimensional profile with many local minima and saddle points, which correspond to different states. Consequently, not only topological defects, but also islands of different metastable states can be created. Using (3)He we can analyse the properties and experimental consequences of such transitions and, in particular, the first-order phase transition between the two low symmetry states.

Crystal water dynamics of guanosine dihydrate: analysis of atomic displacement parameters, time profile of hydrogen-bonding probability, and translocation of water by MD simulation.

PubMed

Yoneda, Shigetaka; Sugawara, Yoko; Urabe, Hisako

2005-01-27

The dynamics of crystal water molecules of guanosine dihydrate are investigated in detail by molecular dynamics (MD) simulation. A 2 ns simulation is performed using a periodic boundary box composed of 4 x 5 x 8 crystallographic unit cells and using the particle-mesh Ewald method for calculation of electrostatic energy. The simulated average atomic positions and atomic displacement parameters are remarkably coincident with the experimental values determined by X-ray analysis, confirming the high accuracy of this simulation. The dynamics of crystal water are analyzed in terms of atomic displacement parameters, orientation vectors, order parameters, self-correlation functions of the orientation vectors, time profiles of hydrogen-bonding probability, and translocations. The simulation clarifies that the average structure is composed of various stable and transient structures of the molecules. The simulated guanosine crystal forms a layered structure, with four water sites per asymmetric unit, classified as either interlayer water or intralayer water. From a detailed analysis of the translocations of water molecules in the simulation, columns of intralayer water molecules along the c axis appear to represent a pathway for hydration and dehydration by a kind of molecular valve mechanism.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kao, Kuo-Hsing; Meyer, Kristin De; Department of Electrical Engineering, KU Leuven, Leuven

Band-to-band tunneling parameters of strained indirect bandgap materials are not well-known, hampering the reliability of performance predictions of tunneling devices based on these materials. The nonlocal band-to-band tunneling model for compressively strained SiGe is calibrated based on a comparison of strained SiGe p-i-n tunneling diode measurements and doping-profile-based diode simulations. Dopant and Ge profiles of the diodes are determined by secondary ion mass spectrometry and capacitance-voltage measurements. Theoretical parameters of the band-to-band tunneling model are calculated based on strain-dependent properties such as bandgap, phonon energy, deformation-potential-based electron-phonon coupling, and hole effective masses of strained SiGe. The latter is determined withmore » a 6-band k·p model. The calibration indicates an underestimation of the theoretical electron-phonon coupling with nearly an order of magnitude. Prospects of compressively strained SiGe tunneling transistors are made by simulations with the calibrated model.« less

Modeling of the laser beam shape for high-power applications

NASA Astrophysics Data System (ADS)

Jabczyński, Jan K.; Kaskow, Mateusz; Gorajek, Lukasz; Kopczyński, Krzysztof; Zendzian, Waldemar

2018-04-01

Aperture losses and thermo-optic effects (TOE) inside optics as well as the effective beam width in far field should be taken into account in the analysis of the most appropriate laser beam profile for high-power applications. We have theoretically analyzed such a problem for a group of super-Gaussian beams taking first only diffraction limitations. Furthermore, we have investigated TOE on far-field parameters of such beams to determine the influence of absorption in optical elements on beam quality degradation. The best compromise gives the super-Gaussian profile of index p = 5, for which beam quality does not decrease noticeably and the thermo-optic higher order aberrations are compensated. The simplified formulas were derived for beam quality metrics (parameter M2 and Strehl ratio), which enable estimation of the influence of heat deposited in optics on degradation of beam quality. The method of dynamic compensation of such effect was proposed.

Spent fuel pool storage calculations using the ISOCRIT burnup credit tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kucukboyaci, Vefa; Marshall, William BJ J

2012-01-01

In order to conservatively apply burnup credit in spent fuel pool criticality safety analyses, Westinghouse has developed a software tool, ISOCRIT, for generating depletion isotopics. This tool is used to create isotopics data based on specific reactor input parameters, such as design basis assembly type; bounding power/burnup profiles; reactor specific moderator temperature profiles; pellet percent theoretical density; burnable absorbers, axial blanket regions, and bounding ppm boron concentration. ISOCRIT generates burnup dependent isotopics using PARAGON; Westinghouse's state-of-the-art and licensed lattice physics code. Generation of isotopics and passing the data to the subsequent 3D KENO calculations are performed in an automated fashion,more » thus reducing the chance for human error. Furthermore, ISOCRIT provides the means for responding to any customer request regarding re-analysis due to changed parameters (e.g., power uprate, exit temperature changes, etc.) with a quick turnaround.« less

Genetic algorithm applied to a Soil-Vegetation-Atmosphere system: Sensitivity and uncertainty analysis

NASA Astrophysics Data System (ADS)

Schneider, Sébastien; Jacques, Diederik; Mallants, Dirk

2010-05-01

Numerical models are of precious help for predicting water fluxes in the vadose zone and more specifically in Soil-Vegetation-Atmosphere (SVA) systems. For such simulations, robust models and representative soil hydraulic parameters are required. Calibration of unsaturated hydraulic properties is known to be a difficult optimization problem due to the high non-linearity of the water flow equations. Therefore, robust methods are needed to avoid the optimization process to lead to non-optimal parameters. Evolutionary algorithms and specifically genetic algorithms (GAs) are very well suited for those complex parameter optimization problems. Additionally, GAs offer the opportunity to assess the confidence in the hydraulic parameter estimations, because of the large number of model realizations. The SVA system in this study concerns a pine stand on a heterogeneous sandy soil (podzol) in the Campine region in the north of Belgium. Throughfall and other meteorological data and water contents at different soil depths have been recorded during one year at a daily time step in two lysimeters. The water table level, which is varying between 95 and 170 cm, has been recorded with intervals of 0.5 hour. The leaf area index was measured as well at some selected time moments during the year in order to evaluate the energy which reaches the soil and to deduce the potential evaporation. Water contents at several depths have been recorded. Based on the profile description, five soil layers have been distinguished in the podzol. Two models have been used for simulating water fluxes: (i) a mechanistic model, the HYDRUS-1D model, which solves the Richards' equation, and (ii) a compartmental model, which treats the soil profile as a bucket into which water flows until its maximum capacity is reached. A global sensitivity analysis (Morris' one-at-a-time sensitivity analysis) was run previously to the calibration, in order to check the sensitivity in the chosen parameter search space. For the inversion procedure a genetical algorithm (GA) was used. Specific features such as elitism, roulette-wheel process for selection operator and island theory were implemented. Optimization was based on the water content measurements recorded at several depths. Ten scenarios have been elaborated and applied on the two lysimeters in order to investigate the impact of the conceptual model in terms of processes description (mechanistic or compartmental) and geometry (number of horizons in the profile description) on the calibration accuracy. Calibration leads to a good agreement with the measured water contents. The most critical parameters for improving the goodness of fit are the number of horizons and the type of process description. Best fit are found for a mechanistic model with 5 horizons resulting in absolute differences between observed and simulated water contents less than 0.02 cm3cm-3 in average. Parameter estimate analysis shows that layers thicknesses are poorly constrained whereas hydraulic parameters are much well defined.

Tension Amplification in Molecular Brushes in Solutions and on Substrates

PubMed Central

Panyukov, Sergey; Zhulina, Ekaterina B.; Sheiko, Sergei S.; Randall, Greg C.; Brock, James; Rubinstein, Michael

2009-01-01

Molecular bottle-brushes are highly branched macromolecules with side chains densely grafted to a long polymer backbone. The brush-like architecture allows focusing of the side-chain tension to the backbone and its amplification from the picoNewton to nanoNewton range. The backbone tension depends on the overall molecular conformation and the surrounding environment. Here we study the relation between the tension and conformation of the molecular brushes in solutions, melts, and on substrates. In solutions, we find that the backbone tension in dense brushes with side chains attached to every backbone monomer is on the order of f0N3/8 in athermal solvents, f0N1/3 in θ-solvents, and f0 in poor solvents and melts, where N is the degree of polymerization of side chains, f0≃ kBT/b is the maximum tension in side chains, b is the Kuhn length, kB is Boltzmann constant, and T is absolute temperature. Depending on the side chain length and solvent quality, molecular brushes in solutions develop tension on the order of 10–100 picoNewtons, which is sufficient to break hydrogen bonds. Significant amplification of tension occurs upon adsorption of brushes onto a substrate. On a strongly attractive substrate, maximum tension in the brush backbone is ~ f0N, reaching values on the order of several nanoNewtons which exceed the strength of a typical covalent bond. At low grafting density and high spreading parameter the cross-sectional profile of adsorbed molecular brush is approximately rectangular with thicknes ~bA/S, where A is the Hamaker constant and S is the spreading parameter. At a very high spreading parameter (S > A), the brush thickness saturates at monolayer ~ b. At a low spreading parameter, the cross-sectional profile of adsorbed molecular brush has triangular tent-like shape. In the cross-over between these two opposite cases, covering a wide range of parameter space, the adsorbed molecular brush consists of two layers. Side chains in the lower layer gain surface energy due to the direct interaction with the substrate, while the second layer spreads on the top of the first layer. Scaling theory predicts that this second layer has a triangular cross-section with width R ~ N3/5 and height h ~ N2/5. Using self-consistent field theory we calculate the cap profile y (x) = h (1 − x2/R2)2, where x is the transverse distance from the backbone. The predicted cap shape is in excellent agreement with both computer simulation and experiment. PMID:19673133

Discovery of safety biomarkers for atorvastatin in rat urine using mass spectrometry based metabolomics combined with global and targeted approach.

PubMed

Kumar, Bhowmik Salil; Lee, Young-Joo; Yi, Hong Jae; Chung, Bong Chul; Jung, Byung Hwa

2010-02-19

In order to develop a safety biomarker for atorvastatin, this drug was orally administrated to hyperlipidemic rats, and a metabolomic study was performed. Atorvastatin was given in doses of either 70 mg kg(-1) day(-1) or 250 mg kg(-1) day(-1) for a period of 7 days (n=4 for each group). To evaluate any abnormal effects of the drug, physiological and plasma biochemical parameters were measured and histopathological tests were carried out. Safety biomarkers were derived by comparing these parameters and using both global and targeted metabolic profiling. Global metabolic profiling was performed using liquid chromatography/time of flight/mass spectrometry (LC/TOF/MS) with multivariate data analysis. Several safety biomarker candidates that included various steroids and amino acids were discovered as a result of global metabolic profiling, and they were also confirmed by targeted metabolic profiling using gas chromatography/mass spectrometry (GC/MS) and capillary electrophoresis/mass spectrometry (CE/MS). Serum biochemical and histopathological tests were used to detect abnormal drug reactions in the liver after repeating oral administration of atorvastatin. The metabolic differences between control and the drug-treated groups were compared using PLS-DA score plots. These results were compared with the physiological and plasma biochemical parameters and the results of a histopathological test. Estrone, cortisone, proline, cystine, 3-ureidopropionic acid and histidine were proposed as potential safety biomarkers related with the liver toxicity of atorvastatin. These results indicate that the combined application of global and targeted metabolic profiling could be a useful tool for the discovery of drug safety biomarkers. Copyright 2009 Elsevier B.V. All rights reserved.

Orientational order in smectic liquid-crystalline phases of amphiphilic diols

NASA Astrophysics Data System (ADS)

Giesselmann, Frank; Germer, Roland; Saipa, Alexander

2005-07-01

The thermotropic smectic phases of amphiphilic 2-(trans-4-n-alkylcyclohexyl)-propane-1,3-diols were investigated by means of small- and wide-angle x-ray scattering and values of the smectic (bi-)layer spacing, the orientational order parameters ⟨P2⟩ and ⟨P4⟩, the orientational distribution function as well as the intralayer correlation length were extracted from the scattering profiles. The results for the octyl homolog indicate that these smectic phases combine a very high degree of smectic one-dimensional-translational order with remarkably low orientational order, the order parameter of which (⟨P2⟩≈0.56) is far below those values typically found in nonamphiphilic smectics. This combination, quite exceptional in thermotropic smectics, most likely originates from the intermolecular hydrogen bonding between the terminal diol groups which seems to be the specific driving force in the formation of the thermotropic smectic structure in these amphiphiles and leads to a type of microphase segregation. Even in the absence of a solvent, the liquid-crystalline ordering of the amphiphilic mesogens comes close to the structure of the so-called neat soaps, found in lyotropic liquid crystals.

On the Geometry of the X-Ray Emission from Pulsars. I. Model Formulation and Tests

NASA Astrophysics Data System (ADS)

Cappallo, Rigel; Laycock, Silas G. T.; Christodoulou, Dimitris M.

2017-12-01

X-ray pulsars are complex magnetized astronomical objects in which many different attributes shape the pulse profiles of the emitted radiation. For each pulsar, the orientation of the spin axis relative to our viewing angle, the inclination of the magnetic dipole axis relative to the spin axis, and the geometries of the emission regions all play key roles in producing its unique pulse profile. In this paper, we describe in detail a new geometric computer model for X-ray emitting pulsars and the tests that we carried out in order to ensure its proper operation. This model allows for simultaneous tuning of multiple parameters for each pulsar and, by fitting observed profiles, it has the potential to determine the underlying geometries of many pulsars whose pulse profiles have been cataloged and made public in modern X-ray databases.

Investigation of Ion-Implanted Photosensitive Silicon Structures by Electrochemical Capacitance–Voltage Profiling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yakovlev, G. E., E-mail: geyakovlev@etu.ru; Frolov, D. S.; Zubkova, A. V.

2016-03-15

The method of electrochemical capacitance–voltage profiling is used to study boron-implanted silicon structures for CCD matrices with backside illumination. A series of specially prepared structures with different energies and doses of ion implantation and also with various materials used for the coating layers (aluminum, silicon oxide, and their combinations) is studied. The profiles of the depth distribution of majority charge carriers of the studied structures are obtained experimentally. Also, using the Poisson equation and the Fredholm equation of the first kind, the distributions of the charge-carrier concentration and of the electric field in the structures are calculated. On the basismore » of the analysis and comparison of theoretical and experimental concentration profiles, recommendations concerning optimization of the structures’ parameters in order to increase the value of the pulling field and decrease the effect of the surface potential on the transport of charge carriers are suggested.« less

Unsteady Sisko magneto-nanofluid flow with heat absorption and temperature dependent thermal conductivity: A 3D numerical study

NASA Astrophysics Data System (ADS)

Khan, Masood; Ahmad, Latif; Gulzar, M. Mudassar

2018-03-01

The impact of temperature dependent thermal conductivity and convective surface conditions on unsteady 3D Sisko nanofluid flow over a stretching surface is studied in the presence of heat generation/absorption and magnetic field. The numerical solution of nonlinear coupled equations has been carried out to explore the properties of different physical profiles of the fluid flow with varying of parameters. Specifically, the application of generalized Biot numbers and heat generation/absorption parameter in the sketching of temperature and concentration profiles are explored. The effect of all three parameters is noticed in the increasing order for shear thinning (0 < n < 1) and for shear thickening (n > 1) fluids. Moreover, the influence of Biot number γ1 on heat and mass transfer rates, are found in the enhancement and diminishing conducts respectively, in both cases of shear thinning as well as shear thickening fluids and a reverse trend is observed with the variation of Biot number γ2 . Additionally, the present results are validated through skin friction, heat and mass transfer rate values with the comparable values in the existing previous values.

Electroosmosis modulated biomechanical transport through asymmetric microfluidics channel

NASA Astrophysics Data System (ADS)

Jhorar, R.; Tripathi, D.; Bhatti, M. M.; Ellahi, R.

2018-05-01

This article addresses the electrokinetically modulated biomechanical transport through a two-dimensional asymmetric microchannel induced by peristaltic waves. Electrokinetic transport with peristaltic phenomena grabbed a significant attention due to its novel applications in engineering. Electrical fields also provide an excellent mode for regulating flows. The electrohydrodynamics problem is modified by means of Debye-Hückel linearization. Firstly, the governing flow problem is described by continuity and momentum equations in the presence of electrokinetic forces in Cartesian coordinates, then long wavelength and low/zero Reynolds ("neglecting the inertial forces") approximations are applied to modify the governing flow problem. The resulting differential equations are solved analytically in order to obtain exact solutions for velocity profile whereas the numerical integration is carried out to analyze the pumping characteristics. The physical behaviour of sundry parameters is discussed for velocity profile, pressure rise and volume flow rate. In particular, the behaviour of electro-osmotic parameter, phase difference, and Helmholtz-Smoluchowski velocity is examined and discussed. The trapping mechanism is also visualized by drawing streamlines against the governing parameters. The present study offers various interesting results that warrant further study on electrokinetic transport with peristalsis.

Stacking fault density and bond orientational order of fcc ruthenium nanoparticles

NASA Astrophysics Data System (ADS)

Seo, Okkyun; Sakata, Osami; Kim, Jae Myung; Hiroi, Satoshi; Song, Chulho; Kumara, Loku Singgappulige Rosantha; Ohara, Koji; Dekura, Shun; Kusada, Kohei; Kobayashi, Hirokazu; Kitagawa, Hiroshi

2017-12-01

We investigated crystal structure deviations of catalytic nanoparticles (NPs) using synchrotron powder X-ray diffraction. The samples were fcc ruthenium (Ru) NPs with diameters of 2.4, 3.5, 3.9, and 5.4 nm. We analyzed average crystal structures by applying the line profile method to a stacking fault model and local crystal structures using bond orientational order (BOO) parameters. The reflection peaks shifted depending on rules that apply to each stacking fault. We evaluated the quantitative stacking faults densities for fcc Ru NPs, and the stacking fault per number of layers was 2-4, which is quite large. Our analysis shows that the fcc Ru 2.4 nm-diameter NPs have a considerably high stacking fault density. The B factor tends to increase with the increasing stacking fault density. A structural parameter that we define from the BOO parameters exhibits a significant difference from the ideal value of the fcc structure. This indicates that the fcc Ru NPs are highly disordered.

Petrophysical Properties (Density and Magnetization) of Rocks from the Suhbaatar-Ulaanbaatar-Dalandzadgad Geophysical Profile in Mongolia and Their Implications

PubMed Central

Gao, Jintian; Gu, Zuowen; Dagva, Baatarkhuu; Tserenpil, Batsaikhan

2013-01-01

Petrophysical properties of 585 rock samples from the Suhbaatar-Ulaanbaatar-Dalandzadgad geophysical profile in Mongolia are presented. Based on the rock classifications and tectonic units, petrophysical parameters (bulk density, magnetic susceptibility, intensity of natural remanent magnetization, and Köenigsberger ratio) of these rocks are summarized. Results indicate that (1) significant density contrast of different rocks would result in variable gravity anomalies along the profile; (2) magnetic susceptibility and natural remanent magnetization of all rocks are variable, covering 5-6 orders of magnitude, which would make a variable induced magnetization and further links to complex magnetic anomalies in ground surface; (3) the distribution of rocks with different lithologies controls the pattern of lithospheric magnetic anomaly along the profile. The petrophysical database thus provides not only one of the keys to understand the geological history and structure of the profile, but also essential information for analysis and interpretation of the geophysical (e.g., magnetic and gravity) survey data. PMID:24324382

Petrophysical properties (density and magnetization) of rocks from the Suhbaatar-Ulaanbaatar-Dalandzadgad geophysical profile in Mongolia and their implications.

PubMed

Yang, Tao; Gao, Jintian; Gu, Zuowen; Dagva, Baatarkhuu; Tserenpil, Batsaikhan

2013-01-01

Petrophysical properties of 585 rock samples from the Suhbaatar-Ulaanbaatar-Dalandzadgad geophysical profile in Mongolia are presented. Based on the rock classifications and tectonic units, petrophysical parameters (bulk density, magnetic susceptibility, intensity of natural remanent magnetization, and Köenigsberger ratio) of these rocks are summarized. Results indicate that (1) significant density contrast of different rocks would result in variable gravity anomalies along the profile; (2) magnetic susceptibility and natural remanent magnetization of all rocks are variable, covering 5-6 orders of magnitude, which would make a variable induced magnetization and further links to complex magnetic anomalies in ground surface; (3) the distribution of rocks with different lithologies controls the pattern of lithospheric magnetic anomaly along the profile. The petrophysical database thus provides not only one of the keys to understand the geological history and structure of the profile, but also essential information for analysis and interpretation of the geophysical (e.g., magnetic and gravity) survey data.

Generation and Characterization of Electron Bunches with Ramped Current Profiles in a Dual-Frequency Superconducting Linear Accelerator

DOE PAGES

Piot, P.; Behrens, C.; Gerth, C.; ...

2011-09-07

We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radiofrequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced {approx} 700-MeV bunches have peak currents of the order of a kilo-Ampere. Data taken for various accelerator settings demonstrate the versatility of the method and in particular its ability to produce current profiles that have a quasi-linear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak acceleratingmore » electric fields with transformer ratios larger than 2 in dielectric-lined waveguides.« less

Generation and characterization of electron bunches with ramped current profiles in a dual-frequency superconducting linear accelerator.

PubMed

Piot, P; Behrens, C; Gerth, C; Dohlus, M; Lemery, F; Mihalcea, D; Stoltz, P; Vogt, M

2012-01-20

We report on the successful experimental generation of electron bunches with ramped current profiles. The technique relies on impressing nonlinear correlations in the longitudinal phase space using a superconducing radio frequency linear accelerator operating at two frequencies and a current-enhancing dispersive section. The produced ~700-MeV bunches have peak currents of the order of a kilo-Ampère. Data taken for various accelerator settings demonstrate the versatility of the method and, in particular, its ability to produce current profiles that have a quasilinear dependency on the longitudinal (temporal) coordinate. The measured bunch parameters are shown, via numerical simulations, to produce gigavolt-per-meter peak accelerating electric fields with transformer ratios larger than 2 in dielectric-lined waveguides. © 2012 American Physical Society

Lateral mode control in edge-emitting lasers with modified mirrors

NASA Astrophysics Data System (ADS)

Payusov, A.; Serin, A.; Mukhin, I.; Shernyakov, Y.; Zadiranov, Y.; Maximov, M.; Gordeev, N.

2017-11-01

We present a study on lateral mode control in edge-emitting lasers with profiled mirror reflectivity. The object was to eliminate high-order lateral modes in conventional ridge-waveguide InAs/InGaAs QD (quantum dot) lasers with the stripe width of 10 μm. We have used a FIB (focused ion beam) technique to selectively etch windows in the AR (anti-reflection) facet coatings in order to introduce extra mirror losses for the high order modes. This approach allowed us to eliminate the first-order mode lasing without deterioration of the laser parameters. We suppose that further optimisation of the laser heterostructure and window designs may lead to a pure lateral single-mode lasing in the broadened ridge waveguides.

Optimization of GATE and PHITS Monte Carlo code parameters for uniform scanning proton beam based on simulation with FLUKA general-purpose code

NASA Astrophysics Data System (ADS)

Kurosu, Keita; Takashina, Masaaki; Koizumi, Masahiko; Das, Indra J.; Moskvin, Vadim P.

2014-10-01

Although three general-purpose Monte Carlo (MC) simulation tools: Geant4, FLUKA and PHITS have been used extensively, differences in calculation results have been reported. The major causes are the implementation of the physical model, preset value of the ionization potential or definition of the maximum step size. In order to achieve artifact free MC simulation, an optimized parameters list for each simulation system is required. Several authors have already proposed the optimized lists, but those studies were performed with a simple system such as only a water phantom. Since particle beams have a transport, interaction and electromagnetic processes during beam delivery, establishment of an optimized parameters-list for whole beam delivery system is therefore of major importance. The purpose of this study was to determine the optimized parameters list for GATE and PHITS using proton treatment nozzle computational model. The simulation was performed with the broad scanning proton beam. The influences of the customizing parameters on the percentage depth dose (PDD) profile and the proton range were investigated by comparison with the result of FLUKA, and then the optimal parameters were determined. The PDD profile and the proton range obtained from our optimized parameters list showed different characteristics from the results obtained with simple system. This led to the conclusion that the physical model, particle transport mechanics and different geometry-based descriptions need accurate customization in planning computational experiments for artifact-free MC simulation.

Non-destructive scanning for applied stress by the continuous magnetic Barkhausen noise method

NASA Astrophysics Data System (ADS)

Franco Grijalba, Freddy A.; Padovese, L. R.

2018-01-01

This paper reports the use of a non-destructive continuous magnetic Barkhausen noise technique to detect applied stress on steel surfaces. The stress profile generated in a sample of 1070 steel subjected to a three-point bending test is analyzed. The influence of different parameters such as pickup coil type, scanner speed, applied magnetic field and frequency band analyzed on the effectiveness of the technique is investigated. A moving smoothing window based on a second-order statistical moment is used to analyze the time signal. The findings show that the technique can be used to detect applied stress profiles.

On the information content of natural frequency spectra associated with different angular numbers. [acoustic velocity in vibrating fluid sphere model of earth structure

NASA Technical Reports Server (NTRS)

Barcilon, V.

1978-01-01

The problem of inferring the speed of sound in a contained spherically symmetric fluid solely from its natural frequencies of vibration is considered. An investigation of the case in which the data consist of the two spectra associated with the angular numbers 0 and 1, suggests the possibility that a one-parameter family of slowness profiles can be constructed. These profiles are compatible with the data, up to first order in the non-uniformity of the fluid. It is conjectured that for other angular numbers, the loss of information increases as the difference between them increases.

KINK AND SAUSAGE MODES IN NONUNIFORM MAGNETIC SLABS WITH CONTINUOUS TRANSVERSE DENSITY DISTRIBUTIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yu, Hui; Li, Bo; Chen, Shao-Xia

2015-11-20

We examine the influence of a continuous density structuring transverse to coronal slabs on the dispersive properties of fundamental standing kink and sausage modes supported therein. We derive generic dispersion relations (DRs) governing linear fast waves in pressureless straight slabs with general transverse density distributions, and focus on cases where the density inhomogeneity takes place in a layer of arbitrary width and in arbitrary form. The physical relevance of the solutions to the DRs is demonstrated by the corresponding time-dependent computations. For all profiles examined, the lowest order kink modes are trapped regardless of longitudinal wavenumber k. A continuous density distribution introducesmore » a difference to their periods of ≲13% when k is the observed range relative to the case where the density profile takes a step function form. Sausage modes and other branches of kink modes are leaky at small k, and their periods and damping times are heavily influenced by how the transverse density profile is prescribed, in particular the length scale. These modes have sufficiently high quality to be observable only for physical parameters representative of flare loops. We conclude that while the simpler DR pertinent to a step function profile can be used for the lowest order kink modes, the detailed information on the transverse density structuring needs to be incorporated into studies of sausage modes and higher order kink modes.« less

An approach to parameter estimation for breast tumor by finite element method

NASA Astrophysics Data System (ADS)

Xu, A.-qing; Yang, Hong-qin; Ye, Zhen; Su, Yi-ming; Xie, Shu-sen

2009-02-01

The temperature of human body on the surface of the skin depends on the metabolic activity, the blood flow, and the temperature of the surroundings. Any abnormality in the tissue, such as the presence of a tumor, alters the normal temperature on the skin surface due to increased metabolic activity of the tumor. Therefore, abnormal skin temperature profiles are an indication of diseases such as tumor or cancer. This study is to present an approach to detect the female breast tumor and its related parameter estimations by combination the finite element method with infrared thermography for the surface temperature profile. A 2D simplified breast embedded a tumor model based on the female breast anatomical structure and physiological characteristics was first established, and then finite element method was used to analyze the heat diffuse equation for the surface temperature profiles of the breast. The genetic optimization algorithm was used to estimate the tumor parameters such as depth, size and blood perfusion by minimizing a fitness function involving the temperature profiles simulated data by finite element method to the experimental data obtained by infrared thermography. This preliminary study shows it is possible to determine the depth and the heat generation rate of the breast tumor by using infrared thermography and the optimization analysis, which may play an important role in the female breast healthcare and diseases evaluation or early detection. In order to develop the proposed methodology to be used in clinical, more accurate anatomy 3D breast geometry should be considered in further investigations.

Robust/optimal temperature profile control of a high-speed aerospace vehicle using neural networks.

PubMed

Yadav, Vivek; Padhi, Radhakant; Balakrishnan, S N

2007-07-01

An approximate dynamic programming (ADP)-based suboptimal neurocontroller to obtain desired temperature for a high-speed aerospace vehicle is synthesized in this paper. A 1-D distributed parameter model of a fin is developed from basic thermal physics principles. "Snapshot" solutions of the dynamics are generated with a simple dynamic inversion-based feedback controller. Empirical basis functions are designed using the "proper orthogonal decomposition" (POD) technique and the snapshot solutions. A low-order nonlinear lumped parameter system to characterize the infinite dimensional system is obtained by carrying out a Galerkin projection. An ADP-based neurocontroller with a dual heuristic programming (DHP) formulation is obtained with a single-network-adaptive-critic (SNAC) controller for this approximate nonlinear model. Actual control in the original domain is calculated with the same POD basis functions through a reverse mapping. Further contribution of this paper includes development of an online robust neurocontroller to account for unmodeled dynamics and parametric uncertainties inherent in such a complex dynamic system. A neural network (NN) weight update rule that guarantees boundedness of the weights and relaxes the need for persistence of excitation (PE) condition is presented. Simulation studies show that in a fairly extensive but compact domain, any desired temperature profile can be achieved starting from any initial temperature profile. Therefore, the ADP and NN-based controllers appear to have the potential to become controller synthesis tools for nonlinear distributed parameter systems.

Retrieval and characterization of ozone profiles from solar infrared spectra at the Jungfraujoch

NASA Astrophysics Data System (ADS)

Barret, B.; de MazièRe, M.; Demoulin, P.

2002-12-01

Vertical distributions of ozone from June 1996 to November 2000 have been retrieved from high-resolution Fourier transform infrared (FTIR) solar absorption spectra recorded at the primary Network for Detection of Stratospheric Change station of the Jungfraujoch in the Swiss Alps (46.5°N, 8°E, 3580 m above sea level (asl). The retrievals were performed using the Optimal Estimation Method (OEM), both in a narrow spectral interval (1002.567-1003.2 cm-1) and in a broad spectral interval (1000.0-1005.0 cm-1) in the O3 9.6-μm band. A thorough characterization of the retrievals has been performed following the lines of OEM, including an information content analysis, a study of the correlations between retrieved instrumental parameters and retrieved ozone concentrations, and an evaluation of the O3 profile error budget. It is demonstrated that the information content is significantly higher for spectra in the broad microwindow, resulting in higher vertical resolutions, on the order of 8 km, of the retrieved profiles extending up to 40 km, and less correlations between retrieved parameters. An independent statistical verification of the retrieval results and their characterization has been performed by comparison of the FTIR ozone profiles with independent measurements. These are the ozone profile measurements from balloon soundings at Payerne, from the microwave radiometer at Bern and the lidar at Observatoire de Haute-Provence (OHP), and the total column data from the Dobson spectrophotometer at Arosa. Applying the optimum retrieval procedure in the broad spectral interval, an excellent agreement has been found between the FTIR O3 profile data and the correlative data. The largest offset of the FTIR data in comparison with the correlative data is found with respect to the lidar data in the 24- to 40-km layer, and is on the order of 5%. No systematic biases have been found in the troposphere, neither in the upper troposphere-lower stratosphere (UTLS) up to 18 km. The dispersion of the relative differences between the data sets, if any, is never larger than half of the natural ozone variability.

Roughness exponent in two-dimensional percolation, Potts model, and clock model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Redinz, Jose Arnaldo; Martins, Marcelo Lobato

We present a numerical study of the self-affine profiles obtained from configurations of the q-state Potts (with q=2,3, and 7) and p=10 clock models as well as from the occupation states for site percolation on the square lattice. The first and second order static phase transitions of the Potts model are located by a sharp change in the value of the roughness exponent {alpha} characterizing those profiles. The low temperature phase of the Potts model corresponds to flat ({alpha}{approx_equal}1) profiles, whereas its high temperature phase is associated with rough ({alpha}{approx_equal}0.5) ones. For the p=10 clock model, in addition to themore » flat (ferromagnetic) and rough (paramagnetic) profiles, an intermediate rough (0.5{lt}{alpha}{lt}1) phase{emdash}associated with a soft spin-wave one{emdash}is observed. Our results for the transition temperatures in the Potts and clock models are in agreement with the static values, showing that this approach is able to detect the phase transitions in these models directly from the spin configurations, without any reference to thermodynamical potentials, order parameters, or response functions. Finally, we show that the roughness exponent {alpha} is insensitive to geometric critical phenomena.« less

Flux tubes and coherence length in the SU(3) vacuum

NASA Astrophysics Data System (ADS)

Cea, P.; Cosmai, L.; Cuteri, F.; Papa, A.

An estimate of the London penetration and coherence lengths in the vacuum of the SU(3) pure gauge theory is given downstream an analysis of the transverse profile of the chromoelectric flux tubes. Within ordinary superconductivity, a simple variational model for the magnitude of the normalized order parameter of an isolated vortex produces an analytic expression for magnetic field and supercurrent density. In the picture of SU(3) vacuum as dual superconductor, this expression provides us with the function that fits the chromoelectric field data. The smearing procedure is used in order to reduce noise.

Models for estimating photosynthesis parameters from in situ production profiles

NASA Astrophysics Data System (ADS)

Kovač, Žarko; Platt, Trevor; Sathyendranath, Shubha; Antunović, Suzana

2017-12-01

The rate of carbon assimilation in phytoplankton primary production models is mathematically prescribed with photosynthesis irradiance functions, which convert a light flux (energy) into a material flux (carbon). Information on this rate is contained in photosynthesis parameters: the initial slope and the assimilation number. The exactness of parameter values is crucial for precise calculation of primary production. Here we use a model of the daily production profile based on a suite of photosynthesis irradiance functions and extract photosynthesis parameters from in situ measured daily production profiles at the Hawaii Ocean Time-series station Aloha. For each function we recover parameter values, establish parameter distributions and quantify model skill. We observe that the choice of the photosynthesis irradiance function to estimate the photosynthesis parameters affects the magnitudes of parameter values as recovered from in situ profiles. We also tackle the problem of parameter exchange amongst the models and the effect it has on model performance. All models displayed little or no bias prior to parameter exchange, but significant bias following parameter exchange. The best model performance resulted from using optimal parameter values. Model formulation was extended further by accounting for spectral effects and deriving a spectral analytical solution for the daily production profile. The daily production profile was also formulated with time dependent growing biomass governed by a growth equation. The work on parameter recovery was further extended by exploring how to extract photosynthesis parameters from information on watercolumn production. It was demonstrated how to estimate parameter values based on a linearization of the full analytical solution for normalized watercolumn production and from the solution itself, without linearization. The paper complements previous works on photosynthesis irradiance models by analysing the skill and consistency of photosynthesis irradiance functions and parameters for modeling in situ production profiles. In light of the results obtained in this work we argue that the choice of the primary production model should reflect the available data and these models should be data driven regarding parameter estimation.

Analysis of FORTE data to extract ionospheric parameters

NASA Astrophysics Data System (ADS)

Roussel-Dupré, Robert A.; Jacobson, Abram R.; Triplett, Laurie A.

2001-01-01

The ionospheric transfer function is derived for a spherically symmetric ionosphere with an arbitrary radial electron density profile in the limit where the radio frequencies of interest ω are much larger than the plasma frequency ωpe. An expansion of the transfer function to second order in the parameter X (= ω2pe/ω2) is carried out. In this limit the dispersive properties of the ionosphere are manifested as a frequency-dependent time of arrival that includes quadratic, cubic, and quartic terms in 1/ω. The coefficients of these terms are related to the total electron content (TEC) along the slant path from transmitter to receiver, the product of TEC and the longitudinal magnetic field strength along the slant path, and refractive bending and higher-order electron density profile effects, respectively. By fitting the time of arrival versus frequency of a transionospheric signal to a polynomial in 1/ω it is possible to extract the TEC, the longitudinal magnetic field strength, the peak electron density, and an effective thickness for the ionosphere. This exercise was carried out for a number of transionospheric pulses measured in the VHF by the FORTE satellite receiver and generated by the Los Alamos Portable Pulser. The results are compared with predictions derived from the International Reference Ionosphere and the United States Geological Survey geomagnetic field model.

Gas metal arc welding in refurbishment of cobalt base superalloys

NASA Astrophysics Data System (ADS)

Shahriary, M. S.; Miladi Gorji, Y.; Kolagar, A. M.

2017-01-01

Refurbishments of superalloys which are used in manufacturing gas turbine hot components usually consists of removing cracks and other defects by blending and then repair welding in order to reconstruct damaged area. In this study, the effects of welding parameters on repair of FSX-414 superalloy, as the most applicable cobalt base superalloy in order to manufacture gas turbine nozzles, by use of Gas Metal Arc Welding (GMAW) technic were investigated. Results then were compared by Gas Tungsten Arc Welding (GTAW). Metallographic and SEM studies of the microstructure of the weld and HAZ showed that there are no noticeable defects in the microstructure by use of GMAW. Also, chemical analysis and morphologies of carbide in both methods are similar. Hardness profile of the GM AW structure then also compared with GTAW and no noticeable difference was observed between the profiles. Also, proper tensile properties, compared with GTAW, can be achieved by use of optimum parameters that can be obtained by examining the current and welding speed. Tensile properties of optimized condition of the GMAW then were compared with GTAW. It was seen that the room and high temperature tensile properties of the GMAW structure is very similar and results confirmed that changing the technic did not have any significant influence on the properties.

Design of broadband dispersion flattened fiber for DWDM system: Performance analysis using various modulation formats

NASA Astrophysics Data System (ADS)

Goel, Aditya; Pandey, Gaurav

2018-05-01

In this paper, unique design of an optimal broadband optical dispersion flattened fiber (DFF) is proposed, which is capable of supporting the data rate of the order of Tb/s. The analysis of the single mode fiber for the design of the proposed DFF has been carried out by employing the quadratic Finite Element Method (FEM) with generalized refractive index (R. I.) profile. The minimization of the dispersion with respect to various profile parameters within the specified wavelength band is the essential optimization criteria. Computations show that a DFF can be designed where the overall dispersion can be restricted within ± 1 ps/km-nm over the entire spectral span ranging from 1290 to 1540 nm (250 nm) exhibiting a very small maximum value of dispersion slope (± 0.02 ps / (nm2-km)) in particular. The detailed performance analysis of the proposed DFF with different modulation techniques has been carried out in order to critically evaluate the performance of the DFF with respect to various significant parameters. The results suggest an excellent design of broadband optical waveguide capable of supporting high-speed data rate (40 Tb/s) through the single DFF, ideally suitable for the long haul dense wavelength division multiplexing (DWDM) optical transmission systems.

Target parameter estimation

NASA Technical Reports Server (NTRS)

Hocking, W. K.

1989-01-01

The objective of any radar experiment is to determine as much as possible about the entities which scatter the radiation. This review discusses many of the various parameters which can be deduced in a radar experiment, and also critically examines the procedures used to deduce them. Methods for determining the mean wind velocity, the RMS fluctuating velocities, turbulence parameters, and the shapes of the scatterers are considered. Complications with these determinations are discussed. It is seen throughout that a detailed understanding of the shape and cause of the scatterers is important in order to make better determinations of these various quantities. Finally, some other parameters, which are less easily acquired, are considered. For example, it is noted that momentum fluxes due to buoyancy waves and turbulence can be determined, and on occasions radars can be used to determine stratospheric diffusion coefficients and even temperature profiles in the atmosphere.

A pictorial study of an invariant torus in phase space of four dimensions.

NASA Technical Reports Server (NTRS)

Baxter, R.; Eiserike, H.; Stokes, A.

1972-01-01

An investigation was conducted with the aid of a computer graphics device at Goddard Space Flight Center to study the behavior of the invariant manifolds of a particular fourth-order equation, as a parameter in the equation is varied over the interval from 0 to 1. The equation consists of two coupled Van der Pol equations. For a small parameter value, the manifold is an asymptotically stable torus, where the flow on the torus is simply a rotation. As the value of the parameter is increased, the only thing that changes is the nature of the flow on the torus, which itself persists throughout the parameter variation. It is shown that ultimately the four periodic cycles which appear play a more significant part in the phase profile of the system than does the torus itself.

A simplified method for power-law modelling of metabolic pathways from time-course data and steady-state flux profiles.

PubMed

Kitayama, Tomoya; Kinoshita, Ayako; Sugimoto, Masahiro; Nakayama, Yoichi; Tomita, Masaru

2006-07-17

In order to improve understanding of metabolic systems there have been attempts to construct S-system models from time courses. Conventionally, non-linear curve-fitting algorithms have been used for modelling, because of the non-linear properties of parameter estimation from time series. However, the huge iterative calculations required have hindered the development of large-scale metabolic pathway models. To solve this problem we propose a novel method involving power-law modelling of metabolic pathways from the Jacobian of the targeted system and the steady-state flux profiles by linearization of S-systems. The results of two case studies modelling a straight and a branched pathway, respectively, showed that our method reduced the number of unknown parameters needing to be estimated. The time-courses simulated by conventional kinetic models and those described by our method behaved similarly under a wide range of perturbations of metabolite concentrations. The proposed method reduces calculation complexity and facilitates the construction of large-scale S-system models of metabolic pathways, realizing a practical application of reverse engineering of dynamic simulation models from the Jacobian of the targeted system and steady-state flux profiles.

X-ray Pulsars Across the Parameter Space of Luminosity, Accretion Mode, and Spin

NASA Astrophysics Data System (ADS)

Laycock, Silas; Yang, Jun; Christodoulou, Dimitris; Coe, Malcolm; Cappallo, Rigel; Zezas, Andreas; Ho, Wynn C. G.; Hong, JaeSub; Fingerman, Samuel; Drake, Jeremy J.; Kretschmar, Peter; Antoniou, Vallia

2017-08-01

We present our multi-satellite library of X-ray Pulsar observations to the community, and highlight recent science results. Available at www.xraypulsars.space the library provides a range of high-level data products, including: activity histories, pulse-profiles, phased event files, and a unique pulse-profile modeling interface. The initial release (v1.0) contains some 15 years of RXTE-PCA, Chandra ACIS-I, and XMM-PN observations of the Small Magellanic Cloud, creating a valuable record of pulsar behavior. Our library is intended to enable new progress on fundamental NS parameters and accretion physics. The major motivations are (1) Assemble a large homogeneous sample to enable population statistics. This has so far been used to map the propeller transition, and explore the role of retrograde and pro-grade accretion disks. (2) Obtain pulse-profiles for the same pulsars on many different occasions, at different luminosities and states in order to break model degeneracies. This effort has led to preliminary measurements of the offsets between magnetic and spin axes. With the addition of other satellites, and Galactic pulsars, the library will cover the entire available range of luminosity, variability timescales and accretion regimes.

Improvements to the George/Castillo Boundary Layer Theory

NASA Astrophysics Data System (ADS)

Wosnik, Martin; George, William K.; Castillo, Luciano

2000-11-01

George and Castillo (1997)(George WK and Castillo L (1997) Appl.Mech.Rev.), 50, 12/1, 689-729. presented a new theory for Zero Pressure Gradient Turbulent Boundary Layers based on an application of Near-Asymptotics to scaling laws derived from equilibrium similarity to the Reynolds-averaged equations. The resulting overlap velocity profiles retained a dependence on local Reynolds number, the parameters for which had to satisfy the following constraint equation: ln \\varepsilon fracdγd ln δ^+ = fracdln [C_o/C_i] d ln δ^+ where γ is the power exponent, Co and Ci are the coefficients in inner and outer variables respectively. GC considered only the first term in an asymptotic expansion of the exact solution, but higher order terms can be considered with no increase in the number of unknowns. The improved theory is tested against new experimental Zero Pressure Gradient Turbulent Boundary Layer data of Smith (1994), Oesterlund (1999) and Johansson and Castillo (2000). For the friction law, the first order term is sufficient, but for Co and γ the higher order terms improve the fit to the velocity profiles significantly.

The torsional energy profile of 1,2-diphenylethane: an ab initio study

NASA Astrophysics Data System (ADS)

Ivanov, Petko M.

1997-08-01

Ab initio molecular orbital calculations were carried out for the antiperiplanar (ap), the synclinal (sc), phenyl/phenyl eclipsed (syn barrier), and phenyl/H eclipsed (ap/sc barrier) conformations of 1,2-diphenylethane, and the energy ordering of conformations thus obtained was compared with the torsional energy profile estimated with the MM2 and MM3 molecular mechanics force fields. The basis set effect on the results was studied at the restricted Hartree-Fock (RHF) self-consistent field (SCF) level of theory, and the electron correlation energies were corrected by the second-order (MP2) Møller-Plesset perturbation treatment using the 6-31G * basis set. The performance of a DFT model (Becke-style three-parameter hybrid method using the correlation functional of Lee, Yang and Parr, B3LYP) was also tested to assess relative energies of the conformations using two basis sets, 6-31G * and 6-311G **. The RHF and B3LYP results are qualitatively the same, while the MP2 calculations produced significant differences in the geometries and reversed the order of preference for the antiperiplanar and the synclinal conformations.

A local PDE model of aggregation formation in bacterial colonies

NASA Astrophysics Data System (ADS)

Chavy-Waddy, Paul-Christopher; Kolokolnikov, Theodore

2016-10-01

We study pattern formation in a model of cyanobacteria motion recently proposed by Galante, Wisen, Bhaya and Levy. By taking a continuum limit of their model, we derive a novel fourth-order nonlinear parabolic PDE equation that governs the behaviour of the model. This PDE is {{u}t}=-{{u}xx}-{{u}xxxx}+α {{≤ft(\\frac{{{u}x}{{u}xx}}{u}\\right)}x} . We then derive the instability thresholds for the onset of pattern formation. We also compute analytically the spatial profiles of the steady state aggregation density. These profiles are shown to be of the form \\text{sec}{{\\text{h}}p} where the exponent p is related to the parameters of the model. Full numerical simulations give a favorable comparison between the continuum and the underlying discrete system, and show that the aggregation profiles are stable above the critical threshold.

Real-time MSE measurements for current profile control on KSTAR.

PubMed

De Bock, M F M; Aussems, D; Huijgen, R; Scheffer, M; Chung, J

2012-10-01

To step up from current day fusion experiments to power producing fusion reactors, it is necessary to control long pulse, burning plasmas. Stability and confinement properties of tokamak fusion reactors are determined by the current or q profile. In order to control the q profile, it is necessary to measure it in real-time. A real-time motional Stark effect diagnostic is being developed at Korean Superconducting Tokamak for Advanced Research for this purpose. This paper focuses on 3 topics important for real-time measurements: minimize the use of ad hoc parameters, minimize external influences and a robust and fast analysis algorithm. Specifically, we have looked into extracting the retardance of the photo-elastic modulators from the signal itself, minimizing the influence of overlapping beam spectra by optimizing the optical filter design and a multi-channel, multiharmonic phase locking algorithm.

A Stokes drift approximation based on the Phillips spectrum

NASA Astrophysics Data System (ADS)

Breivik, Øyvind; Bidlot, Jean-Raymond; Janssen, Peter A. E. M.

2016-04-01

A new approximation to the Stokes drift velocity profile based on the exact solution for the Phillips spectrum is explored. The profile is compared with the monochromatic profile and the recently proposed exponential integral profile. ERA-Interim spectra and spectra from a wave buoy in the central North Sea are used to investigate the behavior of the profile. It is found that the new profile has a much stronger gradient near the surface and lower normalized deviation from the profile computed from the spectra. Based on estimates from two open-ocean locations, an average value has been estimated for a key parameter of the profile. Given this parameter, the profile can be computed from the same two parameters as the monochromatic profile, namely the transport and the surface Stokes drift velocity.

Cooperative ordering and kinetics of cellulose nanocrystal alignment in a magnetic field

DOE PAGES

De France, Kevin J.; Yager, Kevin G.; Hoare, Todd; ...

2016-07-13

Cellulose nanocrystals (CNCs) are emerging nanomaterials that form chiral nematic liquid crystals above a critical concentration (C*) and additionally orient within electromagnetic fields. The control over CNC alignment is significant for materials processing and end use; to date, magnetic alignment has been demonstrated using only strong fields over extended or arbitrary time scales. This work investigates the effects of comparatively weak magnetic fields (0–1.2 T) and CNC concentration (1.65–8.25 wt %) on the kinetics and degree of CNC ordering using small-angle X-ray scattering. Interparticle spacing, correlation length, and orientation order parameters (η and S) increased with time and field strengthmore » following a sigmoidal profile. In a 1.2 T magnetic field for CNC suspensions above C*, partial alignment occurred in under 2 min followed by slower cooperative ordering to achieve nearly perfect alignment in under 200 min (S = –0.499 where S = –0.5 indicates perfect antialignment). At 0.56 T, nearly perfect alignment was also achieved, yet the ordering was 36% slower. Outside of a magnetic field, the order parameter plateaued at 52% alignment (S = –0.26) after 5 h, showcasing the drastic effects of relatively weak magnetic fields on CNC alignment. For suspensions below C*, no magnetic alignment was detected.« less

Nonparaxial Dark-Hollow Gaussian Beams

NASA Astrophysics Data System (ADS)

Gao, Zeng-Hui; Lü, Bai-Da

2006-01-01

The concept of nonparaxial dark-hollow Gaussian beams (DHGBs) is introduced. By using the Rayleigh-Sommerfeld diffraction integral, the analytical propagation equation of DHGBs in free space is derived. The on-axis intensity, far-field equation and, in particular, paraxial expressions are given and treated as special cases of our result. It is shown that the parameter f = 1/kw0 with k being the wave number and w0 being the waist width determines the nonparaxiality of DHGBs. However, the parameter range, within which the paraxial approach is valid, depends on the propagation distance. The beam order affects the beam profile and position of maximum on-axis intensity.

Phase behavior and orientational ordering in block copolymers doped with anisotropic nanoparticles

NASA Astrophysics Data System (ADS)

Osipov, M. A.; Gorkunov, M. V.; Berezkin, A. V.; Kudryavtsev, Y. V.

2018-04-01

A molecular field theory and coarse-grained computer simulations with dissipative particle dynamics have been used to study the spontaneous orientational ordering of anisotropic nanoparticles in the lamellar and hexagonal phases of diblock copolymers and the effect of nanoparticles on the phase behavior of these systems. Both the molecular theory and computer simulations indicate that strongly anisotropic nanoparticles are ordered orientationally mainly in the boundary region between the domains and the nematic order parameter possesses opposite signs in adjacent domains. The orientational order is induced by the boundary and by the interaction between nanoparticles and the monomer units in different domains. In simulations, sufficiently long and strongly selective nanoparticles are ordered also inside the domains. The nematic order parameter and local concentration profiles of nanoparticles have been calculated numerically using the model of a nanoparticle with two interaction centers and also determined using the results of computer simulations. A number of phase diagrams have been obtained which illustrate the effect of nanoparticle selectivity and molar fraction of the stability ranges of various phases. Different morphologies have been identified by analyzing the static structure factor and a phase diagram has been constructed in coordinates' nanoparticle concentration-copolymer composition. Orientational ordering of even a small fraction of nanoparticles may result in a significant increase of the dielectric anisotropy of a polymer nanocomposite, which is important for various applications.

Tunability of temperature dependent THz photonic band gaps in 1-D photonic crystals composed of graded index materials and semiconductor InSb

NASA Astrophysics Data System (ADS)

Singh, Bipin K.; Pandey, Praveen C.; Rastogi, Vipul

2018-05-01

Tunable temperature dependent terahertz photonic band gaps (PBGs) in one-dimensional (1-D) photonic crystal composed of alternating layers of graded index and semiconductor materials are demonstrated. Results show the influence of temperature, geometrical parameters, grading profile and material damping factor on the PBGs. Number of PBG increases with increasing the layer thickness and their bandwidth can be tuned with external temperature and grading parameters. Lower order band gap is more sensitive to the temperature which shows increasing trend with temperature, and higher order PBGs can also be tuned by controlling the external temperature. Band edges of PBGs are shifted toward higher frequency side with increasing the temperature. Results show that the operational frequencies of PBGs are unaffected when loss involved. This work enables to design tunable Temperature dependent terahertz photonic devices such as reflectors, sensors and filters etc.

Stable amorphous binary systems of glipizide and atorvastatin powders with enhanced dissolution profiles: formulation and characterization.

PubMed

Renuka; Singh, Sachin Kumar; Gulati, Monica; Narang, Rakesh

2017-02-01

The aim of this study was to enhance the dissolution profile of the combination of glipizide and atorvastatin used for simultaneous treatment of hyperglycemia and hyperlipidemia. The strategy to formulate coamorphous glipizide-atorvastatin binary mixture was explored to achieve enhancement in dissolution. The coamorphous glipizide-atorvastatin mixtures (1:1, 1:2 and 2:1) were prepared by cryomilling and characterized with respect to their dissolution profiles, preformulation parameters and physical stability. Amorphization was found to be possible by cryomilling at various tried ratios of the two drugs. The data obtained from glass transition temperatures and from Raman spectroscopy point toward practically no interaction between the two drugs. The dissolution studies revealed the highest enhancement in dissolution profiles of cryomilled coamorphous mixtures containing GPZ:ATV in ratios 1:1 (B-5) and 2:1 (B-7). These two mixtures were, therefore, subjected to studies for the evaluation of precompression parameters in order to find their amenability to satisfactory compression into tablet dosage form. The selected formulation was found to be stable when subjected to accelerated stability testing at 40°. C/75% RH for six months as per ICH guidelines. Based on all these studies, it was concluded that GPZ:ATV (1:1) combination may be able to provide an effective therapy for the comorbidities of hyperglycemia and hyperlipidemia.

Tracking control of concentration profiles in a fed-batch bioreactor using a linear algebra methodology.

PubMed

Rómoli, Santiago; Serrano, Mario Emanuel; Ortiz, Oscar Alberto; Vega, Jorge Rubén; Eduardo Scaglia, Gustavo Juan

2015-07-01

Based on a linear algebra approach, this paper aims at developing a novel control law able to track reference profiles that were previously-determined in the literature. A main advantage of the proposed strategy is that the control actions are obtained by solving a system of linear equations. The optimal controller parameters are selected through Monte Carlo Randomized Algorithm in order to minimize a proposed cost index. The controller performance is evaluated through several tests, and compared with other controller reported in the literature. Finally, a Monte Carlo Randomized Algorithm is conducted to assess the performance of the proposed controller. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

Enhanced THz radiation generation by photo-mixing of tophat lasers in rippled density plasma with a planar magnetostatic wiggler and s-parameter

NASA Astrophysics Data System (ADS)

Abedi-Varaki, M.

2018-02-01

In this paper, the effects of planar magnetostatic wiggler and s-parameter on the terahertz (THz) radiation generation through rippled plasma have been investigated. Efficient THz radiation generation by photo-mixing of tophat lasers for rippled density plasma in the presence of the wiggler field has been presented. Fundamental equations for the analysis of the non-linear current density and THz radiation generation by wiggler magnetostatic field have been derived. It is shown that for the higher order of the tophat lasers, the values of THz amplitude are greater. In fact, the higher order of the tophat lasers has a sharp gradient in the intensity of lasers, which leads to a stronger nonlinear ponderomotive force and, consequently, a stronger current density. In addition, it is seen that by increasing s-parameter, the normalized transverse profile becomes more focused near the axis of y. Furthermore, it is observed that the normalized laser efficiency has a decreasing trend with increasing normalized THz frequency for different values of the wiggler field. Also, it is shown that by employing a greater order of the tophat lasers and a stronger wiggler field, the efficiency of order of 30% can be achieved. Moreover, it is found that we can control focus and intensity of THz radiation emitted in rippled plasma by choosing the appropriate order of the tophat lasers and tuning of the wiggler field.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Zhuoyu; Yuan, Hongtao; Xie, Yanwu

Carrier density and disorder are two crucial parameters that control the properties of correlated two-dimensional electron systems. Furthermore, in order to disentangle their individual contributions to quantum phenomena, independent tuning of these two parameters is required. By utilizing a hybrid liquid/solid electric dual-gate geometry acting on the conducting LaAlO 3/SrTiO 3 heterointerface, we obtain an additional degree of freedom to strongly modify the electron confinement profile and thus the strength of interfacial scattering, independent from the carrier density. A dual-gate controlled nonlinear Hall effect is a direct manifestation of this profile, which can be quantitatively understood by a Poisson–Schrödinger sub-bandmore » model. In particular, the large nonlinear dielectric response of SrTiO 3 enables a very wide range of tunable density and disorder, far beyond that for conventional semiconductors. This study provides a broad framework for understanding various reported phenomena at the LaAlO 3/SrTiO 3 interface.« less

Exploiting the full power of temporal gene expression profiling through a new statistical test: application to the analysis of muscular dystrophy data.

PubMed

Vinciotti, Veronica; Liu, Xiaohui; Turk, Rolf; de Meijer, Emile J; 't Hoen, Peter A C

2006-04-03

The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Most statistical methods used in the literature do not fully exploit the temporal ordering in the dataset and are not suited to the case where temporal profiles are measured for a number of different biological conditions. We present a statistical test that makes explicit use of the temporal order in the data by fitting polynomial functions to the temporal profile of each gene and for each biological condition. A Hotelling T2-statistic is derived to detect the genes for which the parameters of these polynomials are significantly different from each other. We validate the temporal Hotelling T2-test on muscular gene expression data from four mouse strains which were profiled at different ages: dystrophin-, beta-sarcoglycan and gamma-sarcoglycan deficient mice, and wild-type mice. The first three are animal models for different muscular dystrophies. Extensive biological validation shows that the method is capable of finding genes with temporal profiles significantly different across the four strains, as well as identifying potential biomarkers for each form of the disease. The added value of the temporal test compared to an identical test which does not make use of temporal ordering is demonstrated via a simulation study, and through confirmation of the expression profiles from selected genes by quantitative PCR experiments. The proposed method maximises the detection of the biologically interesting genes, whilst minimising false detections. The temporal Hotelling T2-test is capable of finding relatively small and robust sets of genes that display different temporal profiles between the conditions of interest. The test is simple, it can be used on gene expression data generated from any experimental design and for any number of conditions, and it allows fast interpretation of the temporal behaviour of genes. The R code is available from V.V. The microarray data have been submitted to GEO under series GSE1574 and GSE3523.

Exploiting the full power of temporal gene expression profiling through a new statistical test: Application to the analysis of muscular dystrophy data

PubMed Central

Vinciotti, Veronica; Liu, Xiaohui; Turk, Rolf; de Meijer, Emile J; 't Hoen, Peter AC

2006-01-01

Background The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Most statistical methods used in the literature do not fully exploit the temporal ordering in the dataset and are not suited to the case where temporal profiles are measured for a number of different biological conditions. We present a statistical test that makes explicit use of the temporal order in the data by fitting polynomial functions to the temporal profile of each gene and for each biological condition. A Hotelling T2-statistic is derived to detect the genes for which the parameters of these polynomials are significantly different from each other. Results We validate the temporal Hotelling T2-test on muscular gene expression data from four mouse strains which were profiled at different ages: dystrophin-, beta-sarcoglycan and gamma-sarcoglycan deficient mice, and wild-type mice. The first three are animal models for different muscular dystrophies. Extensive biological validation shows that the method is capable of finding genes with temporal profiles significantly different across the four strains, as well as identifying potential biomarkers for each form of the disease. The added value of the temporal test compared to an identical test which does not make use of temporal ordering is demonstrated via a simulation study, and through confirmation of the expression profiles from selected genes by quantitative PCR experiments. The proposed method maximises the detection of the biologically interesting genes, whilst minimising false detections. Conclusion The temporal Hotelling T2-test is capable of finding relatively small and robust sets of genes that display different temporal profiles between the conditions of interest. The test is simple, it can be used on gene expression data generated from any experimental design and for any number of conditions, and it allows fast interpretation of the temporal behaviour of genes. The R code is available from V.V. The microarray data have been submitted to GEO under series GSE1574 and GSE3523. PMID:16584545

Reduced-order model for dynamic optimization of pressure swing adsorption processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, A.; Biegler, L.; Zitney, S.

2007-01-01

Over the past decades, pressure swing adsorption (PSA) processes have been widely used as energy-efficient gas and liquid separation techniques, especially for high purity hydrogen purification from refinery gases. The separation processes are based on solid-gas equilibrium and operate under periodic transient conditions. Models for PSA processes are therefore multiple instances of partial differential equations (PDEs) in time and space with periodic boundary conditions that link the processing steps together. The solution of this coupled stiff PDE system is governed by steep concentrations and temperature fronts moving with time. As a result, the optimization of such systems for either designmore » or operation represents a significant computational challenge to current differential algebraic equation (DAE) optimization techniques and nonlinear programming algorithms. Model reduction is one approach to generate cost-efficient low-order models which can be used as surrogate models in the optimization problems. The study develops a reduced-order model (ROM) based on proper orthogonal decomposition (POD), which is a low-dimensional approximation to a dynamic PDE-based model. Initially, a representative ensemble of solutions of the dynamic PDE system is constructed by solving a higher-order discretization of the model using the method of lines, a two-stage approach that discretizes the PDEs in space and then integrates the resulting DAEs over time. Next, the ROM method applies the Karhunen-Loeve expansion to derive a small set of empirical eigenfunctions (POD modes) which are used as basis functions within a Galerkin's projection framework to derive a low-order DAE system that accurately describes the dominant dynamics of the PDE system. The proposed method leads to a DAE system of significantly lower order, thus replacing the one obtained from spatial discretization before and making optimization problem computationally-efficient. The method has been applied to the dynamic coupled PDE-based model of a two-bed four-step PSA process for separation of hydrogen from methane. Separate ROMs have been developed for each operating step with different POD modes for each of them. A significant reduction in the order of the number of states has been achieved. The gas-phase mole fraction, solid-state loading and temperature profiles from the low-order ROM and from the high-order simulations have been compared. Moreover, the profiles for a different set of inputs and parameter values fed to the same ROM were compared with the accurate profiles from the high-order simulations. Current results indicate the proposed ROM methodology as a promising surrogate modeling technique for cost-effective optimization purposes. Moreover, deviations from the ROM for different set of inputs and parameters suggest that a recalibration of the model is required for the optimization studies. Results for these will also be presented with the aforementioned results.« less

Planetary gear profile modification design based on load sharing modelling

NASA Astrophysics Data System (ADS)

Iglesias, Miguel; Fernández Del Rincón, Alfonso; De-Juan, Ana Magdalena; Garcia, Pablo; Diez, Alberto; Viadero, Fernando

2015-07-01

In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications.

Spectral Variability of the Herbig Ae/Be Star HD 37806

NASA Astrophysics Data System (ADS)

Pogodin, M. A.; Pavlovskiy, S. E.; Kozlova, O. V.; Beskrovnaya, N. G.; Alekseev, I. Yu.; Valyavin, G. G.

2018-03-01

Results are reported from a spectroscopic study of the Herbig Ae/Be star HD 37806 from 2009 through 2017 using high resolution spectrographs at the Crimean Astrophysical Observatory and the OAN SPM Observatory in Mexico. 72 spectra of this object near the Hα, Hβ, HeI 5876 and D NaI lines are analyzed. The following results were obtained: 1. The type of spectral profile of the Hα line can change from P Cyg III to double emission and vice versa over a time scale on the order of a month. 2. Narrow absorption components are observed in the profiles of the Hα and D NaI lines with radial velocities that vary over a characteristic time on the order of a day. 3. On some days, the profiles of the Hβ, HeI 5876, and D NaI lines show signs of accretion of matter to the star with a characteristic lifetime of a few days. A possible interpretation of these phenomena was considered. The transformation of the Hα profile may be related to a change in the outer latitudinal width of the boundary of the wind zone. The narrow variable absorption lines may be caused by the rotation of local azimuthal inhomogeneities in the wind zone owing to the interaction of the disk with the star's magnetosphere in a propeller regime. Several current theoretical papers that predict the formation of similar inhomogeneous wind structures were examined. It is suggested that the episodes with signs of accretion in the spectral line profiles cannot be a consequence of the modulation of these profiles by the star's rotation but are more likely caused by sudden, brief changes in the accretion rate. These spectral observations of HD 37806 should be continued in a search for cyclical variability in the spectral parameters in order to identify direct signs of magnetospheric accretion and detect possible binary behavior in this object.

Profiling of patterned metal layers by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

NASA Astrophysics Data System (ADS)

Bi, Melody; Ruiz, Antonio M.; Gornushkin, Igor; Smith, Ben W.; Winefordner, James D.

2000-02-01

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used for profiling patterned thin metal layers on a polymer/silicon substrate. The parameters of the laser and ICP-MS operating conditions have been studied and optimized for this purpose. A new laser ablation chamber was designed and built to achieve the best spatial resolution. The results of the profiling by LA-ICP-MS were compared to those obtained from a laser ablation optical emission spectrometry (LA-OES) instrument, which measured the emission of the plasma at the sample surface, and thus, eliminated the time delay caused by the sample transport into the ICP-MS system. Emission spectra gave better spatial resolution than mass spectra. However, LA-ICP-MS provided much better sensitivity and was able to profile thin metal layers (on the order of a few nanometers) on the silicon surface. A lateral spatial resolution of 45 μm was achieved.

Structure of micro-instabilities in tokamak plasmas: Stiff transport or plasma eruptions?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickinson, D., E-mail: dd502@york.ac.uk; EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon, Oxon OX14 3DB; Roach, C. M.

2014-01-15

Solutions to a model 2D eigenmode equation describing micro-instabilities in tokamak plasmas are presented that demonstrate a sensitivity of the mode structure and stability to plasma profiles. In narrow regions of parameter space, with special plasma profiles, a maximally unstable mode is found that balloons on the outboard side of the tokamak. This corresponds to the conventional picture of a ballooning mode. However, for most profiles, this mode cannot exist, and instead, a more stable mode is found that balloons closer to the top or bottom of the plasma. Good quantitative agreement with a 1D ballooning analysis is found, providedmore » the constraints associated with higher order profile effects, often neglected, are taken into account. A sudden transition from this general mode to the more unstable ballooning mode can occur for a critical flow shear, providing a candidate model for why some experiments observe small plasma eruptions (Edge Localised Modes, or ELMs) in place of large Type I ELMs.« less

Analysis of Total Electron Content and Electron Density Profile during Different Geomagnetic Storms

NASA Astrophysics Data System (ADS)

Chapagain, N. P.; Rana, B.; Adhikari, B.

2017-12-01

Total Electron content (TEC) and electron density are the key parameters in the mitigation of ionospheric effects on radio communication system. Detail study of the TEC and electron density variations has been carried out during geomagnetic storms, with longitude and latitude, for four different locations: (13˚N -17˚N, 88˚E -98˚E), (30˚N-50˚N, 120˚W -95˚W), (29˚S-26˚S, 167˚W-163˚W,) and (60˚S-45˚S, 120˚W-105˚W) using the Gravity Recovery and Climate Experiment (GRACE) satellite observations. In order to find the geomagnetic activity, the solar wind parameters such as north-south component of inter planetary magnetic field (Bz), plasma drift velocity (Vsw), flow pressure (nPa), AE, Dst and Kp indices were obtained from Operating Mission as Nodes on the Internet (OMNI) web system. The data for geomagnetic indices have been correlated with the TEC and electron density for four different events of geomagnetic storms on 6 April 2008, 27 March 2008, 4 September 2008, and 11 October 2008. The result illustrates that the observed TEC and electron density profile significantly vary with longitudes and latitudes. This study illustrates that the values of TEC and the vertical electron density profile are influenced by the solar wind parameters associated with solar activities. The peak values of electron density and TEC increase as the geomagnetic storms become stronger. Similarly, the electron density profile varies with altitudes, which peaks around the altitude range of about 250- 350 km, depending on the strength of geomagnetic storms. The results clearly show that the peak electron density shifted to higher altitude (from about 250 km to 350 km) as the geomagnetic disturbances becomes stronger.

Magnetic Properties of A Bulgarian Loess/paleosol Profile Related To The Pedogenic Enhancement Model

NASA Astrophysics Data System (ADS)

van Velzen, A. J.; Jordanova, D.; Bachtadse, V.

Magnetic susceptibility variations along the loess/palaeosol profile at Lubenovo (Cen- tral North Bulgaria) covering the last 800 ky show strong discrimination between loess and palaeosol units. Variations in susceptibility () and its frequency dependent part (FD) are consistent with a varying pedogenic component with fixed grain-size distri- bution superimposed on a background level (BG) of pristine loess material through- out the 62 m long profile. In the lower half a BG of 1.9*10-6 m3/kg was extrap- olated, opposed to 2.7*10-6 m3/kg in the upper half (with the exception of a 1 m interval at the base of a paleosol at 10 m depth). A variation in source material can be inferred. After subtraction of BG, FD is close to 14 % in paleosol and in loess layers, compliant with a log-normal grain-size distribution for the pedogenic magnetic fraction. Thermomagnetic measurements identify both magnetite and maghemite. The presence of superficially oxidised magnetite grains is inferred from measurements of rockmagnetic parameters before and after heating to 150 C. Hysteresis and back-field measurements show minima for Hc and Hcr in paleosol layers. Viscous magnetisation in paleosol layers is an order of magnitude larger than in loess layers. Magnetic pa- rameters in the top half and the bottom half of the profile react in a different way to heating to 150 C. The magnitude of the changes after heating is proposed as a new analytical parameter. Measurements of hysteresis loops at several temperatures up to 500 C and at room temperature after these heating steps allow monitoring of temper- ature dependence of magnetic parameters and the detection of alterations involving magnetic minerals.

Global Sampling for Integrating Physics-Specific Subsystems and Quantifying Uncertainties of CO 2 Geological Sequestration

DOE PAGES

Sun, Y.; Tong, C.; Trainor-Guitten, W. J.; ...

2012-12-20

The risk of CO 2 leakage from a deep storage reservoir into a shallow aquifer through a fault is assessed and studied using physics-specific computer models. The hypothetical CO 2 geological sequestration system is composed of three subsystems: a deep storage reservoir, a fault in caprock, and a shallow aquifer, which are modeled respectively by considering sub-domain-specific physics. Supercritical CO 2 is injected into the reservoir subsystem with uncertain permeabilities of reservoir, caprock, and aquifer, uncertain fault location, and injection rate (as a decision variable). The simulated pressure and CO 2/brine saturation are connected to the fault-leakage model as amore » boundary condition. CO 2 and brine fluxes from the fault-leakage model at the fault outlet are then imposed in the aquifer model as a source term. Moreover, uncertainties are propagated from the deep reservoir model, to the fault-leakage model, and eventually to the geochemical model in the shallow aquifer, thus contributing to risk profiles. To quantify the uncertainties and assess leakage-relevant risk, we propose a global sampling-based method to allocate sub-dimensions of uncertain parameters to sub-models. The risk profiles are defined and related to CO 2 plume development for pH value and total dissolved solids (TDS) below the EPA's Maximum Contaminant Levels (MCL) for drinking water quality. A global sensitivity analysis is conducted to select the most sensitive parameters to the risk profiles. The resulting uncertainty of pH- and TDS-defined aquifer volume, which is impacted by CO 2 and brine leakage, mainly results from the uncertainty of fault permeability. Subsequently, high-resolution, reduced-order models of risk profiles are developed as functions of all the decision variables and uncertain parameters in all three subsystems.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Y.; Tong, C.; Trainor-Guitten, W. J.

The risk of CO 2 leakage from a deep storage reservoir into a shallow aquifer through a fault is assessed and studied using physics-specific computer models. The hypothetical CO 2 geological sequestration system is composed of three subsystems: a deep storage reservoir, a fault in caprock, and a shallow aquifer, which are modeled respectively by considering sub-domain-specific physics. Supercritical CO 2 is injected into the reservoir subsystem with uncertain permeabilities of reservoir, caprock, and aquifer, uncertain fault location, and injection rate (as a decision variable). The simulated pressure and CO 2/brine saturation are connected to the fault-leakage model as amore » boundary condition. CO 2 and brine fluxes from the fault-leakage model at the fault outlet are then imposed in the aquifer model as a source term. Moreover, uncertainties are propagated from the deep reservoir model, to the fault-leakage model, and eventually to the geochemical model in the shallow aquifer, thus contributing to risk profiles. To quantify the uncertainties and assess leakage-relevant risk, we propose a global sampling-based method to allocate sub-dimensions of uncertain parameters to sub-models. The risk profiles are defined and related to CO 2 plume development for pH value and total dissolved solids (TDS) below the EPA's Maximum Contaminant Levels (MCL) for drinking water quality. A global sensitivity analysis is conducted to select the most sensitive parameters to the risk profiles. The resulting uncertainty of pH- and TDS-defined aquifer volume, which is impacted by CO 2 and brine leakage, mainly results from the uncertainty of fault permeability. Subsequently, high-resolution, reduced-order models of risk profiles are developed as functions of all the decision variables and uncertain parameters in all three subsystems.« less

Optical gradients in a-Si:H thin films detected using real-time spectroscopic ellipsometry with virtual interface analysis

NASA Astrophysics Data System (ADS)

Junda, Maxwell M.; Karki Gautam, Laxmi; Collins, Robert W.; Podraza, Nikolas J.

2018-04-01

Virtual interface analysis (VIA) is applied to real time spectroscopic ellipsometry measurements taken during the growth of hydrogenated amorphous silicon (a-Si:H) thin films using various hydrogen dilutions of precursor gases and on different substrates during plasma enhanced chemical vapor deposition. A procedure is developed for optimizing VIA model configurations by adjusting sampling depth into the film and the analyzed spectral range such that model fits with the lowest possible error function are achieved. The optimal VIA configurations are found to be different depending on hydrogen dilution, substrate composition, and instantaneous film thickness. A depth profile in the optical properties of the films is then extracted that results from a variation in an optical absorption broadening parameter in a parametric a-Si:H model as a function of film thickness during deposition. Previously identified relationships are used linking this broadening parameter to the overall shape of the optical properties. This parameter is observed to converge after about 2000-3000 Å of accumulated thickness in all layers, implying that similar order in the a-Si:H network can be reached after sufficient thicknesses. In the early stages of growth, however, significant variations in broadening resulting from substrate- and processing-induced order are detected and tracked as a function of bulk layer thickness yielding an optical property depth profile in the final film. The best results are achieved with the simplest film-on-substrate structures while limitations are identified in cases where films have been deposited on more complex substrate structures.

Analysis of the Tikhonov regularization to retrieve thermal conductivity depth-profiles from infrared thermography data

NASA Astrophysics Data System (ADS)

Apiñaniz, Estibaliz; Mendioroz, Arantza; Salazar, Agustín; Celorrio, Ricardo

2010-09-01

We analyze the ability of the Tikhonov regularization to retrieve different shapes of in-depth thermal conductivity profiles, usually encountered in hardened materials, from surface temperature data. Exponential, oscillating, and sigmoidal profiles are studied. By performing theoretical experiments with added white noises, the influence of the order of the Tikhonov functional and of the parameters that need to be tuned to carry out the inversion are investigated. The analysis shows that the Tikhonov regularization is very well suited to reconstruct smooth profiles but fails when the conductivity exhibits steep slopes. We check a natural alternative regularization, the total variation functional, which gives much better results for sigmoidal profiles. Accordingly, a strategy to deal with real data is proposed in which we introduce this total variation regularization. This regularization is applied to the inversion of real data corresponding to a case hardened AISI1018 steel plate, giving much better anticorrelation of the retrieved conductivity with microindentation test data than the Tikhonov regularization. The results suggest that this is a promising way to improve the reliability of local inversion methods.

Trans-dimensional joint inversion of seabed scattering and reflection data.

PubMed

Steininger, Gavin; Dettmer, Jan; Dosso, Stan E; Holland, Charles W

2013-03-01

This paper examines joint inversion of acoustic scattering and reflection data to resolve seabed interface roughness parameters (spectral strength, exponent, and cutoff) and geoacoustic profiles. Trans-dimensional (trans-D) Bayesian sampling is applied with both the number of sediment layers and the order (zeroth or first) of auto-regressive parameters in the error model treated as unknowns. A prior distribution that allows fluid sediment layers over an elastic basement in a trans-D inversion is derived and implemented. Three cases are considered: Scattering-only inversion, joint scattering and reflection inversion, and joint inversion with the trans-D auto-regressive error model. Including reflection data improves the resolution of scattering and geoacoustic parameters. The trans-D auto-regressive model further improves scattering resolution and correctly differentiates between strongly and weakly correlated residual errors.

Satellite-derived vertical profiles of temperature and dew point for mesoscale weather forecast

NASA Astrophysics Data System (ADS)

Masselink, Thomas; Schluessel, P.

1995-12-01

Weather forecast-models need spatially high resolutioned vertical profiles of temperature and dewpoint for their initialisation. These profiles can be supplied by a combination of data from the Tiros-N Operational Vertical Sounder (TOVS) and the imaging Advanced Very High Resolution Radiometer (AVHRR) on board the NOAA polar orbiting sate!- lites. In cloudy cases the profiles derived from TOVS data only are of insufficient accuracy. The stanthrd deviations from radiosonde ascents or numerical weather analyses likely exceed 2 K in temperature and 5Kin dewpoint profiles. It will be shown that additional cloud information as retrieved from AVHIRR allows a significant improvement in theaccuracy of vertical profiles. The International TOVS Processing Package (ITPP) is coupled to an algorithm package called AVHRR Processing scheme Over cLouds, Land and Ocean (APOLLO) where parameters like cloud fraction and cloud-top temperature are determined with higher accuracy than obtained from TOVS retrieval alone. Furthermore, a split-window technique is applied to the cloud-free AVHRR imagery in order to derive more accurate surface temperatures than can be obtained from the pure TOVS retrieval. First results of the impact of AVHRR cloud detection on the quality of the profiles are presented. The temperature and humidity profiles of different retrieval approaches are validated against analyses of the European Centre for Medium-Range Weatherforecasts.

Transfer characteristics of optical profilers with respect to rectangular edge and step height measurement

NASA Astrophysics Data System (ADS)

Xie, Weichang; Hagemeier, Sebastian; Bischoff, Jörg; Mastylo, Rostyslav; Manske, Eberhard; Lehmann, Peter

2017-06-01

Optical profilers are mature instruments used in research and industry to study surface topography features. Although the corresponding standards are based on simple step height measurements, in practical applications these instruments are often used to study the fidelity of surface topography. In this context it is well-known that in certain situations a surface profile obtained by an optical profiler will differ from the real profile. With respect to practical applications such deviations often occur in the vicinity of steep walls and in cases of high aspect ratio. In this contribution we compare the transfer characteristics of different 3D optical profiler principles, namely white-light interferometry, focus sensing, and confocal microscopy. Experimental results demonstrate that the transfer characteristics do not only depend on the parameters of the optical measurement system (e. g. wavelength and coherence of light, numerical aperture, evaluated signal feature, polarization) but also on the properties of the measuring object such as step height, aspect ratio, material properties and homogeneity, rounding and steepness of the edges, surface roughness. As a result, typical artefacts such as batwings occur for certain parameter combinations, particularly at certain height-to-wavelength ratio (HWR) values. Understanding of the mechanisms behind these phenomena enables to reduce them by an appropriate parameter adaption. However, it is not only the edge artefacts, but also the position of an edge that may be changed due to the properties of the measuring object. In order to investigate the relevant effects theoretically, several models are introduced. These are based on either an extension of Richards-Wolf modeling or rigorous coupled wave analysis (RCWA). Although these models explain the experimental effects quite well they suffer from different limitations, so that a quantitative correspondence of theoretical modeling and experimental results is hard to achieve. Nevertheless, these models are used to study the characteristics of the measured signals occurring at edges of different step height compared to signals occurring at plateaus. Moreover, a special calibration sample with continuous step height variation was developed to reduce the impact of unknown sample properties. We analyzed the signals in both, the spatial and the spatial frequency domain, and found systematic signal changes that will be discussed. As a consequence, these simulations will help to interpret measurement results appropriately and to improve them by proper parameter settings and calibration and finally to increase the edge detection accuracy.

Computational Study of Chaotic and Ordered Solutions of the Kuramoto-Sivashinsky Equation

NASA Technical Reports Server (NTRS)

Smyrlis, Yiorgos S.; Papageorgiou, Demetrios T.

1996-01-01

We report the results of extensive numerical experiments on the Kuramoto-Sivashinsky equation in the strongly chaotic regime as the viscosity parameter is decreased and increasingly more linearly unstable modes enter the dynamics. General initial conditions are used and evolving states do not assume odd-parity. A large number of numerical experiments are employed in order to obtain quantitative characteristics of the dynamics. We report on different routes to chaos and provide numerical evidence and construction of strange attractors with self-similar characteristics. As the 'viscosity' parameter decreases the dynamics becomes increasingly more complicated and chaotic. In particular it is found that regular behavior in the form of steady state or steady state traveling waves is supported amidst the time-dependent and irregular motions. We show that multimodal steady states emerge and are supported on decreasing windows in parameter space. In addition we invoke a self-similarity property of the equation, to show that these profiles are obtainable from global fixed point attractors of the Kuramoto-Sivashinsky equation at much larger values of the viscosity.

Spectra of High-Ionization Seyfert 1 Galaxies: Implications for the Narrow-Line Region

NASA Technical Reports Server (NTRS)

Moore, David; Cohen, Ross D.; Marcy, Geoffrey W.

1996-01-01

We present line profiles and profile parameters for the Narrow-Line Regions (NLRs) of six Seyfert 1 galaxies with high-ionization lines: MCG 8-11-11, Mrk 79, Mrk 704, Mrk 841, NGC 4151, and NGC 5548. The sample was chosen primarily with the goal of obtaining high-quality [Fe VII] lambda6087 and, when possible, [Fe X] lambda6374 profiles to determine if these lines are more likely formed in a physically distinct 'coronal line region' or are formed throughout the NLR along with lines of lower critical density (n(sub cr)) and/or Ionization Potential (IP). We discuss correlations of velocity shift and width with n(sub cr) and IP. In some objects, lines of high IP and/or n(sub cr) are systematically broader than those of low IP/n(sub cr). Of particular interest, however, are objects that show no correlations of line width with either IP or n(sub cr). In these objects, lines of high and low IP/n(sub cr), are remarkably similar, which is difficult to reconcile with the classical picture of the NLR, in which lines of high and low IP/n(sub cr) are formed in physically distinct regions. We argue for similar spatial extents for the flux in lines with similar profiles. Here, as well as in a modeling-oriented companion paper, we develop further an idea suggested by Moore & Cohen that objects that do and do not show line width correlations with IP/n(sub cr) can both be explained in terms of a single NLR model with only a small difference in the cloud column density distinguishing the two types of object. Overall, our objects do not show correlations between the Full Width at Half-Maximum (FWHM) and IP and/or n(sub cr). The width must be defined by a parameter that is sensitive to extended profile wings in order for the correlations to result. We present models in which FWHM correlations with IP and/or n(sub cr) result only after simulating the lower spectral resolution used in previous observational studies. The models that simulate the higher spectral resolution of our observational study produce line width correlations only if the width is defined by a parameter that is more sensitive to extended profile wings than is the FWHM. Our sample of six objects is in effect augmented by incorporating the larger sample (16 objects) of Veilleux into some of our discussion. This paper focuses on new interpretations of NLR emission-line spectra and line profiles that stem directly from the observations. Paper 2 focuses on modeling and complements this paper by illustrating explicitly the effects that spatial variations in electron density, ionization parameter, and column density have on model profiles. By comparing model profiles with the observed profiles presented here, as well as with those presented by Veilleux, Paper 2 yields insight into how the electron density, ionization parameter, and column density likely vary throughout the NLR.

Elastic full-waveform inversion and parameterization analysis applied to walk-away vertical seismic profile data for unconventional (heavy oil) reservoir characterization

NASA Astrophysics Data System (ADS)

Pan, Wenyong; Innanen, Kristopher A.; Geng, Yu

2018-03-01

Seismic full-waveform inversion (FWI) methods hold strong potential to recover multiple subsurface elastic properties for hydrocarbon reservoir characterization. Simultaneously updating multiple physical parameters introduces the problem of interparameter tradeoff, arising from the covariance between different physical parameters, which increases nonlinearity and uncertainty of multiparameter FWI. The coupling effects of different physical parameters are significantly influenced by model parameterization and acquisition arrangement. An appropriate choice of model parameterization is critical to successful field data applications of multiparameter FWI. The objective of this paper is to examine the performance of various model parameterizations in isotropic-elastic FWI with walk-away vertical seismic profile (W-VSP) dataset for unconventional heavy oil reservoir characterization. Six model parameterizations are considered: velocity-density (α, β and ρ΄), modulus-density (κ, μ and ρ), Lamé-density (λ, μ΄ and ρ‴), impedance-density (IP, IS and ρ″), velocity-impedance-I (α΄, β΄ and I_P^'), and velocity-impedance-II (α″, β″ and I_S^'). We begin analyzing the interparameter tradeoff by making use of scattering radiation patterns, which is a common strategy for qualitative parameter resolution analysis. In this paper, we discuss the advantages and limitations of the scattering radiation patterns and recommend that interparameter tradeoffs be evaluated using interparameter contamination kernels, which provide quantitative, second-order measurements of the interparameter contaminations and can be constructed efficiently with an adjoint-state approach. Synthetic W-VSP isotropic-elastic FWI experiments in the time domain verify our conclusions about interparameter tradeoffs for various model parameterizations. Density profiles are most strongly influenced by the interparameter contaminations; depending on model parameterization, the inverted density profile can be over-estimated, under-estimated or spatially distorted. Among the six cases, only the velocity-density parameterization provides stable and informative density features not included in the starting model. Field data applications of multicomponent W-VSP isotropic-elastic FWI in the time domain were also carried out. The heavy oil reservoir target zone, characterized by low α-to-β ratios and low Poisson's ratios, can be identified clearly with the inverted isotropic-elastic parameters.

Elastic full-waveform inversion and parameterization analysis applied to walk-away vertical seismic profile data for unconventional (heavy oil) reservoir characterization

DOE PAGES

Pan, Wenyong; Innanen, Kristopher A.; Geng, Yu

2018-03-06

We report seismic full-waveform inversion (FWI) methods hold strong potential to recover multiple subsurface elastic properties for hydrocarbon reservoir characterization. Simultaneously updating multiple physical parameters introduces the problem of interparameter tradeoff, arising from the covariance between different physical parameters, which increases nonlinearity and uncertainty of multiparameter FWI. The coupling effects of different physical parameters are significantly influenced by model parameterization and acquisition arrangement. An appropriate choice of model parameterization is critical to successful field data applications of multiparameter FWI. The objective of this paper is to examine the performance of various model parameterizations in isotropic-elastic FWI with walk-away vertical seismicmore » profile (W-VSP) dataset for unconventional heavy oil reservoir characterization. Six model parameterizations are considered: velocity-density (α, β and ρ'), modulus-density (κ, μ and ρ), Lamé-density (λ, μ' and ρ'''), impedance-density (IP, IS and ρ''), velocity-impedance-I (α', β' and I' P), and velocity-impedance-II (α'', β'' and I'S). We begin analyzing the interparameter tradeoff by making use of scattering radiation patterns, which is a common strategy for qualitative parameter resolution analysis. In this paper, we discuss the advantages and limitations of the scattering radiation patterns and recommend that interparameter tradeoffs be evaluated using interparameter contamination kernels, which provide quantitative, second-order measurements of the interparameter contaminations and can be constructed efficiently with an adjoint-state approach. Synthetic W-VSP isotropic-elastic FWI experiments in the time domain verify our conclusions about interparameter tradeoffs for various model parameterizations. Density profiles are most strongly influenced by the interparameter contaminations; depending on model parameterization, the inverted density profile can be over-estimated, under-estimated or spatially distorted. Among the six cases, only the velocity-density parameterization provides stable and informative density features not included in the starting model. Field data applications of multicomponent W-VSP isotropic-elastic FWI in the time domain were also carried out. Finally, the heavy oil reservoir target zone, characterized by low α-to-β ratios and low Poisson’s ratios, can be identified clearly with the inverted isotropic-elastic parameters.« less

Elastic full-waveform inversion and parameterization analysis applied to walk-away vertical seismic profile data for unconventional (heavy oil) reservoir characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pan, Wenyong; Innanen, Kristopher A.; Geng, Yu

We report seismic full-waveform inversion (FWI) methods hold strong potential to recover multiple subsurface elastic properties for hydrocarbon reservoir characterization. Simultaneously updating multiple physical parameters introduces the problem of interparameter tradeoff, arising from the covariance between different physical parameters, which increases nonlinearity and uncertainty of multiparameter FWI. The coupling effects of different physical parameters are significantly influenced by model parameterization and acquisition arrangement. An appropriate choice of model parameterization is critical to successful field data applications of multiparameter FWI. The objective of this paper is to examine the performance of various model parameterizations in isotropic-elastic FWI with walk-away vertical seismicmore » profile (W-VSP) dataset for unconventional heavy oil reservoir characterization. Six model parameterizations are considered: velocity-density (α, β and ρ'), modulus-density (κ, μ and ρ), Lamé-density (λ, μ' and ρ'''), impedance-density (IP, IS and ρ''), velocity-impedance-I (α', β' and I' P), and velocity-impedance-II (α'', β'' and I'S). We begin analyzing the interparameter tradeoff by making use of scattering radiation patterns, which is a common strategy for qualitative parameter resolution analysis. In this paper, we discuss the advantages and limitations of the scattering radiation patterns and recommend that interparameter tradeoffs be evaluated using interparameter contamination kernels, which provide quantitative, second-order measurements of the interparameter contaminations and can be constructed efficiently with an adjoint-state approach. Synthetic W-VSP isotropic-elastic FWI experiments in the time domain verify our conclusions about interparameter tradeoffs for various model parameterizations. Density profiles are most strongly influenced by the interparameter contaminations; depending on model parameterization, the inverted density profile can be over-estimated, under-estimated or spatially distorted. Among the six cases, only the velocity-density parameterization provides stable and informative density features not included in the starting model. Field data applications of multicomponent W-VSP isotropic-elastic FWI in the time domain were also carried out. Finally, the heavy oil reservoir target zone, characterized by low α-to-β ratios and low Poisson’s ratios, can be identified clearly with the inverted isotropic-elastic parameters.« less

Elastic full-waveform inversion and parametrization analysis applied to walk-away vertical seismic profile data for unconventional (heavy oil) reservoir characterization

NASA Astrophysics Data System (ADS)

Pan, Wenyong; Innanen, Kristopher A.; Geng, Yu

2018-06-01

Seismic full-waveform inversion (FWI) methods hold strong potential to recover multiple subsurface elastic properties for hydrocarbon reservoir characterization. Simultaneously updating multiple physical parameters introduces the problem of interparameter trade-off, arising from the simultaneous variations of different physical parameters, which increase the nonlinearity and uncertainty of multiparameter FWI. The coupling effects of different physical parameters are significantly influenced by model parametrization and acquisition arrangement. An appropriate choice of model parametrization is important to successful field data applications of multiparameter FWI. The objective of this paper is to examine the performance of various model parametrizations in isotropic-elastic FWI with walk-away vertical seismic profile (W-VSP) data for unconventional heavy oil reservoir characterization. Six model parametrizations are considered: velocity-density (α, β and ρ΄), modulus-density (κ, μ and ρ), Lamé-density (λ, μ΄ and ρ‴), impedance-density (IP, IS and ρ″), velocity-impedance-I (α΄, β΄ and I_P^' }) and velocity-impedance-II (α″, β″ and I_S^' }). We begin analysing the interparameter trade-off by making use of scattering radiation patterns, which is a common strategy for qualitative parameter resolution analysis. We discuss the advantages and limitations of the scattering radiation patterns and recommend that interparameter trade-offs be evaluated using interparameter contamination kernels, which provide quantitative, second-order measurements of the interparameter contaminations and can be constructed efficiently with an adjoint-state approach. Synthetic W-VSP isotropic-elastic FWI experiments in the time domain verify our conclusions about interparameter trade-offs for various model parametrizations. Density profiles are most strongly influenced by the interparameter contaminations; depending on model parametrization, the inverted density profile can be overestimated, underestimated or spatially distorted. Among the six cases, only the velocity-density parametrization provides stable and informative density features not included in the starting model. Field data applications of multicomponent W-VSP isotropic-elastic FWI in the time domain were also carried out. The heavy oil reservoir target zone, characterized by low α-to-β ratios and low Poisson's ratios, can be identified clearly with the inverted isotropic-elastic parameters.

Determination of Critical Parameters Based on the Intensity of Transmitted Light Around Gas-Liquid Interface: Critical Parameters of CO

NASA Astrophysics Data System (ADS)

Nakayama, Masaki; Katano, Hiroaki; Sato, Haruki

2014-05-01

A precise determination of the critical temperature and density for technically important fluids would be possible on the basis of the digital image for the visual observation of the phase boundary in the vicinity of the critical point since the sensitivity and resolution are higher than those of naked eyes. In addition, the digital image can avoid the personal uncertainty of an observer. A strong density gradient occurs in a sample cell at the critical point due to gravity. It was carefully assessed to determine the critical density, where the density profile in the sample cell can be observed from the luminance profile of a digital image. The density-gradient profile becomes symmetric at the critical point. One of the best fluids, whose thermodynamic properties have been measured with the highest reliability among technically important fluids, would be carbon dioxide. In order to confirm the reliability of the proposed method, the critical temperature and density of carbon dioxide were determined using the digital image. The critical temperature and density values of carbon dioxide are ( and ( kg m, respectively. The critical temperature and density values agree with the existing best values within estimated uncertainties. The reliability of the method was confirmed. The critical pressure, 7.3795 MPa, corresponding to the determined critical temperature of 304.143 K is also proposed. A new set of parameters for the vapor-pressure equation is also provided.

Axisymmetric Powell-Eyring fluid flow over a stretching sheet with a convective boundary condition and suction effects

NASA Astrophysics Data System (ADS)

Nasir, Nor Ain Azeany Mohd; Ishak, Anuar; Pop, Ioan

2018-04-01

In this paper, the heat and mass transfer of an axisymmetric Powell-Eyring fluid flow over a stretching sheet with a convective boundary condition and suction effects are investigated. An appropriate similarity transformation is used to reduce the highly non-linear partial differential equation into second and third order non-linear ordinary differential equations. Numerical solutions of the reduced governing equations are computed numerically by utilizing the MATLAB's built-in boundary value problem solver, bvp4c. The physical significance of various parameters such as Biot number, fluid parameters and Prandtl number on the velocity and temperature evolution profiles are illustrated graphically. The effects of these governing parameters on the skin friction coefficient and the local Nusselt number are also displayed graphically. It is noticed that the Powell-Eyring fluid parameter gives significant influence on the rates of heat and mass transfer of the fluid.

Determining Spacecraft Reaction Wheel Friction Parameters

NASA Technical Reports Server (NTRS)

Sarani, Siamak

2009-01-01

Software was developed to characterize the drag in each of the Cassini spacecraft's Reaction Wheel Assemblies (RWAs) to determine the RWA friction parameters. This tool measures the drag torque of RWAs for not only the high spin rates (greater than 250 RPM), but also the low spin rates (less than 250 RPM) where there is a lack of an elastohydrodynamic boundary layer in the bearings. RWA rate and drag torque profiles as functions of time are collected via telemetry once every 4 seconds and once every 8 seconds, respectively. Intermediate processing steps single-out the coast-down regions. A nonlinear model for the drag torque as a function of RWA spin rate is incorporated in order to characterize the low spin rate regime. The tool then uses a nonlinear parameter optimization algorithm based on the Nelder-Mead simplex method to determine the viscous coefficient, the Dahl friction, and the two parameters that account for the low spin-rate behavior.

Parametric optimisation and microstructural analysis on high power Yb-fibre laser welding of Ti-6Al-4V

NASA Astrophysics Data System (ADS)

Ahn, J.; Chen, L.; Davies, C. M.; Dear, J. P.

2016-11-01

In this work thin sheets of Ti-6Al-4V were full penetration welded using a 5 kW fibre laser in order to evaluate the effectiveness of high power fibre laser as a welding processing tool for welding Ti-6Al-4V with the requirements of the aircraft industry and to determine the effect of welding parameters including laser power, welding speed and beam focal position on the weld microstructure, bead profile and weld quality. It involved establishing an understanding of the influence of welding parameters on microstructural change, welding defects, and the characteristics of heat affected zone (HAZ) and weld metal (WM) of fibre laser welded joints. The optimum range of welding parameters which produced welds without cracking and porosity were identified. The influence of the welding parameters on the weld joint heterogeneity was characterised by conducting detailed microstructural analysis.

Chemically reactive species in squeezed flow through modified Fourier's and Fick's laws

NASA Astrophysics Data System (ADS)

Farooq, M.; Ahmad, S.; Javed, M.; Anjum, Aisha

2018-02-01

The squeezing flow of a Newtonian fluid with variable viscosity over a stretchable sheet embedded in Darcy porous medium is addressed. Cattaneo-Christov double diffusion models are adopted to disclose the salient features of heat and mass transport via variable thermal conductivity and variable mass diffusivity instead of conventional Fourier's and Fick's laws. Further, the concept of heat generation/absorption coefficient and first-order chemical reaction are also imposed to illustrate the characteristics of heat and mass transfer. Highly nonlinear computations are developed in dimensionless form and analyzed via the homotopic technique. The variation of flow parameters on velocity, concentration, and temperature distributions are sketched and disclosed physically. The results found that both concentration and temperature distributions decay for higher solutal and thermal relaxation parameters, respectively. Moreover, a higher chemical reaction parameter results in the reduction of the concentration field whereas the temperature profile enhances for a higher heat generation/absorption parameter.

Application of Layered Perforation Profile Control Technique to Low Permeable Reservoir

NASA Astrophysics Data System (ADS)

Wei, Sun

2018-01-01

it is difficult to satisfy the demand of profile control of complex well section and multi-layer reservoir by adopting the conventional profile control technology, therefore, a research is conducted on adjusting the injection production profile with layered perforating parameters optimization. i.e. in the case of coproduction for multi-layer, water absorption of each layer is adjusted by adjusting the perforating parameters, thus to balance the injection production profile of the whole well section, and ultimately enhance the oil displacement efficiency of water flooding. By applying the relationship between oil-water phase percolation theory/perforating damage and capacity, a mathematic model of adjusting the injection production profile with layered perforating parameters optimization, besides, perforating parameters optimization software is programmed. Different types of optimization design work are carried out according to different geological conditions and construction purposes by using the perforating optimization design software; furthermore, an application test is done for low permeable reservoir, and the water injection profile tends to be balanced significantly after perforation with optimized parameters, thereby getting a good application effect on site.

Dark localized structures in a cavity filled with a left-handed material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tlidi, Mustapha; Kockaert, Pascal; Gelens, Lendert

2011-07-15

We consider a nonlinear passive optical cavity filled with left-handed and right-handed materials and driven by a coherent injected beam. We assume that both left-handed and right-handed materials possess a Kerr focusing type of nonlinearity. We show that close to the zero-diffraction regime, high-order diffraction allows us to stabilize dark localized structures in this device. These structures consist of dips in the transverse profile of the intracavity field and do not exist without high-order diffraction. We analyze the snaking bifurcation diagram associated with these structures. Finally, a realistic estimation of the model parameters is provided.

Novel approaches to increasing the brightness of broad area lasers

NASA Astrophysics Data System (ADS)

Crump, P.; Winterfeldt, M.; Decker, J.; Ekterai, M.; Fricke, J.; Knigge, S.; Maaßdorf, A.; Erbert, G.

2016-03-01

Progress in studies to increase the lateral brightness Blat of broad area lasers is reviewed. Blat=Pout/BPPlat is maximized by developing designs and technology for lowest lateral beam parameter product, BPPlat, at highest optical output power Pout. This can be achieved by limiting the number of guided lateral modes and by improving the beam quality of low-order lateral modes. Important effects to address include process and packaging induced wave-guiding, lateral carrier accumulation and the thermal lens profile. A careful selection of vertical design is also shown to be important, as are advanced techniques to filter out higher order modes.

All half-lives are wrong, but some half-lives are useful.

PubMed

Wright, J G; Boddy, A V

2001-01-01

The half-life of a drug, which expresses a change in concentration in units of time, is perhaps the most easily understood pharmacokinetic parameter and provides a succinct description of many concentration-time profiles. The calculation of a half-life implies a linear, first-order, time-invariant process. No drug perfectly obeys such assumptions, although in practise this is often a valid approximation and provides invaluable quantitative information. Nevertheless, the physiological processes underlying half-life should not be forgotten. The concept of clearance facilitates the interpretation of factors affecting drug elimination, such as enzyme inhibition or renal impairment. Relating clearance to the observed concentration-time profile is not as naturally intuitive as is the case with half-life. As such, these 2 approaches to parameterising a linear pharmacokinetic model should be viewed as complementary rather than alternatives. The interpretation of pharmacokinetic parameters when there are multiple disposition phases is more challenging. Indeed, in any pharmacokinetic model, the half-lives are only one component of the parameters required to specify the concentration-time profile. Furthermore, pharmacokinetic parameters are of little use without a dose history. Other factors influencing the relevance of each disposition phase to clinical end-points must also be considered. In summarising the pharmacokinetics of a drug, statistical aspects of the estimation of a half-life are often overlooked. Half-lives are rarely reported with confidence intervals or measures of variability in the population, and some approaches to this problem are suggested. Half-life is an important summary statistic in pharmacokinetics, but care must be taken to employ it appropriately in the context of dose history and clinically relevant pharmacodynamic end-points.

Role of roughness parameters on the tribology of randomly nano-textured silicon surface.

PubMed

Gualtieri, E; Pugno, N; Rota, A; Spagni, A; Lepore, E; Valeri, S

2011-10-01

This experimental work is oriented to give a contribution to the knowledge of the relationship among surface roughness parameters and tribological properties of lubricated surfaces; it is well known that these surface properties are strictly related, but a complete comprehension of such correlations is still far to be reached. For this purpose, a mechanical polishing procedure was optimized in order to induce different, but well controlled, morphologies on Si(100) surfaces. The use of different abrasive papers and slurries enabled the formation of a wide spectrum of topographical irregularities (from the submicro- to the nano-scale) and a broad range of surface profiles. An AFM-based morphological and topographical campaign was carried out to characterize each silicon rough surface through a set of parameters. Samples were subsequently water lubricated and tribologically characterized through ball-on-disk tribometer measurements. Indeed, the wettability of each surface was investigated by measuring the water droplet contact angle, that revealed a hydrophilic character for all the surfaces, even if no clear correlation with roughness emerged. Nevertheless, this observation brings input to the purpose, as it allows to exclude that the differences in surface profile affect lubrication. So it is possible to link the dynamic friction coefficient of rough Si samples exclusively to the opportune set of surface roughness parameters that can exhaustively describe both height amplitude variations (Ra, Rdq) and profile periodicity (Rsk, Rku, Ic) that influence asperity-asperity interactions and hydrodynamic lift in different ways. For this main reason they cannot be treated separately, but with dependent approach through which it was possible to explain even counter intuitive results: the unexpected decreasing of friction coefficient with increasing Ra is justifiable by a more consistent increasing of kurtosis Rku.

Parameter optimization for surface flux transport models

NASA Astrophysics Data System (ADS)

Whitbread, T.; Yeates, A. R.; Muñoz-Jaramillo, A.; Petrie, G. J. D.

2017-11-01

Accurate prediction of solar activity calls for precise calibration of solar cycle models. Consequently we aim to find optimal parameters for models which describe the physical processes on the solar surface, which in turn act as proxies for what occurs in the interior and provide source terms for coronal models. We use a genetic algorithm to optimize surface flux transport models using National Solar Observatory (NSO) magnetogram data for Solar Cycle 23. This is applied to both a 1D model that inserts new magnetic flux in the form of idealized bipolar magnetic regions, and also to a 2D model that assimilates specific shapes of real active regions. The genetic algorithm searches for parameter sets (meridional flow speed and profile, supergranular diffusivity, initial magnetic field, and radial decay time) that produce the best fit between observed and simulated butterfly diagrams, weighted by a latitude-dependent error structure which reflects uncertainty in observations. Due to the easily adaptable nature of the 2D model, the optimization process is repeated for Cycles 21, 22, and 24 in order to analyse cycle-to-cycle variation of the optimal solution. We find that the ranges and optimal solutions for the various regimes are in reasonable agreement with results from the literature, both theoretical and observational. The optimal meridional flow profiles for each regime are almost entirely within observational bounds determined by magnetic feature tracking, with the 2D model being able to accommodate the mean observed profile more successfully. Differences between models appear to be important in deciding values for the diffusive and decay terms. In like fashion, differences in the behaviours of different solar cycles lead to contrasts in parameters defining the meridional flow and initial field strength.

Trenched raised cosine FMF for differential mode delay management in next generation optical networks

NASA Astrophysics Data System (ADS)

Chebaane, Saleh; Fathallah, Habib; Seleem, Hussein; Machhout, Mohsen

2018-02-01

Dispersion management in few mode fiber (FMF) technology is crucial to support the upcoming standard that reaches 400 Gbps and Terabit/s per wavelength. Recently in Chebaane et al. (2016), we defined two potential differential mode delay (DMD) management strategies, namely sawtooth and triangular. Moreover we proposed a novel parametric refractive index profile for FMF, referred as raised cosine (RC) profile. In this article, we improve and optimize the RC profile design by including additional shaping parameters, in order to obtain much more attractive dispersion characteristics. Our improved design enabled to obtain a zero DMD (z-DMD), strong positive DMD (p-DMD) and near-zero DMD (nz-DMD) for six-mode fiber, all appropriate for dispersion management in FMF system. In addition, we propose a positive DMD (p-DMD) fiber designs for both, four-mode fiber (4-FMF) and six-mode fiber (6-FMF), respectively, having particularly attractive dispersion characteristics.

Field Measurements of the 1983 Royal Gardens Lava Flows, Kilauea Volcano, and 1984 Mauna Loa Lava Flow, Hawaii

NASA Technical Reports Server (NTRS)

Fink, J.; Zimbelman, J.

1985-01-01

Theoretical models used in the remote determination of lava flow rheology and compositions rely on estimates of such geometric and flow parameters as volume flow rates, levee heights, and channel dimensions, as well as morphologic and structural patterns on the flow surfaces. Quantitative measures of these variables are difficult to obtain, even under optimum conditions. Detailed topographic profiles across several Hawaiian lava flows that were carefully monitored by the U.S. Geological Survey during their emplacement in 1983 were surveyed in order to test various flow emplacement models. Twenty two accurate channel cross sections were constructed by combining these profiles with digitized pre-flow topographic measurements. Levee heights, shear zone widths, and flow depths could then be read directly from the cross sections and input into the models. The profiles were also compared with ones constructed for some Martian lava flows.

Shock wave boundary layer interaction on suction side of compressor profile in single passage test section

NASA Astrophysics Data System (ADS)

Flaszynski, Pawel; Doerffer, Piotr; Szwaba, Ryszard; Kaczynski, Piotr; Piotrowicz, Michal

2015-11-01

The shock wave boundary layer interaction on the suction side of transonic compressor blade is one of the main objectives of TFAST project (Transition Location Effect on Shock Wave Boundary Layer Interaction). In order to investigate the flow structure on the suction side of a profile, a design of a generic test section in linear transonic wind tunnel was proposed. The experimental and numerical results for the flow structure investigations are shown for the flow conditions as the existing ones on the suction side of the compressor profile. Near the sidewalls the suction slots are applied for the corner flow structure control. It allows to control the Axial Velocity Density Ratio (AVDR), important parameter for compressor cascade investigations. Numerical results for Explicit Algebraic Reynolds Stress Model with transition modeling are compared with oil flow visualization, schlieren and Pressure Sensitive Paint. Boundary layer transition location is detected by Temperature Sensitive Paint.

An accurate analytic description of neutrino oscillations in matter

NASA Astrophysics Data System (ADS)

Akhmedov, E. Kh.; Niro, Viviana

2008-12-01

A simple closed-form analytic expression for the probability of two-flavour neutrino oscillations in a matter with an arbitrary density profile is derived. Our formula is based on a perturbative expansion and allows an easy calculation of higher order corrections. The expansion parameter is small when the density changes relatively slowly along the neutrino path and/or neutrino energy is not very close to the Mikheyev-Smirnov-Wolfenstein (MSW) resonance energy. Our approximation is not equivalent to the adiabatic approximation and actually goes beyond it. We demonstrate the validity of our results using a few model density profiles, including the PREM density profile of the Earth. It is shown that by combining the results obtained from the expansions valid below and above the MSW resonance one can obtain a very good description of neutrino oscillations in matter in the entire energy range, including the resonance region.

Stratified wakes, the high Froude number approximation, and potential flow

NASA Astrophysics Data System (ADS)

Vasholz, David P.

2011-12-01

Properties of a steady wake generated by a body moving uniformly at constant depth through a stratified fluid are studied as a function of two parameters inserted into the linearized equations of motion. The first parameter, μ, multiplies the along-track gradient term in the source equation. When formal solutions for an arbitrary buoyancy frequency profile are written as eigenfunction expansions, one finds that the limit μ → 0 corresponds to a high Froude number approximation accompanied by a substantial reduction in the complexity of the calculation. For μ = 1, upstream effects are present and the eigenvalues correspond to critical speeds above which transverse waves disappear for any given mode. For sufficiently high modes, the high Froude number approximation is valid. The second tracer multiplies the square of the buoyancy frequency term in the linearized conservation of mass equation and enables direct comparisons with the limit of potential flow. Detailed results are given for the simplest possible profile, in which the buoyancy frequency is independent of depth; emphasis is placed upon quantities that can, in principle, be experimentally measured in a laboratory experiment. The vertical displacement field is written in terms of a stratified wake form factor {{H}} , which is the sum of a wavelike contribution that is non-zero downstream and an evanescent contribution that appears symmetrically upstream and downstream. First- and second-order cross-track moments of {{H}} are analyzed. First-order results predict enhanced upstream vertical displacements. Second-order results expand upon previous predictions of wavelike resonances and also predict evanescent resonance effects.

The effect of non-sphericity on mass and anisotropy measurements in dSph galaxies with Schwarzschild method

NASA Astrophysics Data System (ADS)

Kowalczyk, Klaudia; Łokas, Ewa L.; Valluri, Monica

2018-05-01

In our previous work we confirmed the reliability of the spherically symmetric Schwarzschild orbit-superposition method to recover the mass and velocity anisotropy profiles of spherical dwarf galaxies. Here, we investigate the effect of its application to intrinsically non-spherical objects. For this purpose we use a model of a dwarf spheroidal galaxy formed in a numerical simulation of a major merger of two discy dwarfs. The shape of the stellar component of the merger remnant is axisymmetric and prolate which allows us to identify and measure the bias caused by observing the spheroidal galaxy along different directions, especially the longest and shortest principal axis. The modelling is based on mock data generated from the remnant that are observationally available for dwarfs: projected positions and line-of-sight velocities of the stars. In order to obtain a reliable tool while keeping the number of parameters low we parametrize the total mass distribution as a radius-dependent mass-to-light ratio with just two free parameters we aim to constrain. Our study shows that if the total density profile is known, the true, radially increasing anisotropy profile can be well recovered for the observations along the longest axis whereas the data along the shortest axis lead to the inference of an incorrect, isotropic model. On the other hand, if the density profile is derived from the method as well, the anisotropy is always underestimated but the total mass profile is well recovered for the data along the shortest axis whereas for the longest axis the mass content is overestimated.

Morphology and anisotropy of thin conductive inkjet printed lines of single-walled carbon nanotubes

NASA Astrophysics Data System (ADS)

Torres-Canas, Fernando; Blanc, Christophe; Mašlík, Jan; Tahir, Said; Izard, Nicolas; Karasahin, Senguel; Castellani, Mauro; Dammasch, Matthias; Zamora-Ledezma, Camilo; Anglaret, Eric

2017-03-01

We show that the properties of thin conductive inkjet printed lines of single-walled carbon nanotubes (SWCNT) can be greatly tuned, using only a few deposition parameters. The morphology, anisotropy and electrical resistivity of single-stroke printed lines are studied as a function of ink concentration and drop density. An original method based on coupled profilometry-Raman measurements is developed to determine the height, mass, orientational order and density profiles of SWCNT across the printed lines with a micrometric lateral resolution. Height profiles can be tuned from ‘rail tracks’ (twin parallel lines) to layers of homogeneous thickness by controlling nanotube concentration and drop density. In all samples, the nanotubes are strongly oriented parallel to the line axis at the edges of the lines, and the orientational order decreases continuously towards the center of the lines. The resistivity of ‘rail tracks’ is significantly larger than that of homogeneous deposits, likely because of large amounts of electrical dead-ends.

Modeling and studying of white light emitting diodes based on CdS/ZnS spherical quantum dots

NASA Astrophysics Data System (ADS)

Hasanirokh, K.; Asgari, A.

2018-07-01

In this paper, we propose a quantum dot (QD) based white light emitting diode (WLED) structure to study theoretically the material gain and quantum efficiency of the system. We consider the spherical QDs with a II-VI semiconductor core (CdS) that covered with a wider band gap semiconductor acting as a shell (ZnS). In order to generate white light spectrum, we use layers with different dot size that can emit blue, green and red colors. The blue emission originating from CdS core combines to green/orange components originating from ZnS shell and creates an efficiency white light emission. To model this device, at first, we solve Schrödinger and Poisson equations self consistently and obtain eigen energies and wave functions. Then, we calculate the optical gain and internal quantum efficiency (IQE) of a CdS/ZnS LED sample. We investigate the structural parameter effects on the optical properties of the WLED. The numerical results show that the gain profile and IQE curves depend strongly on the structural parameters such as dot size, carrier density and volume scaling parameter. The gain profile becomes higher and wider with increasing the core radius while it becomes less and narrower with increasing the shell thickness. Furthermore, it is found that the volume scaling parameter can manage the system quantum efficiency.

Speed dependence of CH335Cl-O2 line-broadening parameters probed on rotational transitions: Measurements and semi-classical calculations

NASA Astrophysics Data System (ADS)

Buldyreva, J.; Margulès, L.; Motiyenko, R. A.; Rohart, F.

2013-11-01

Relaxation parameters for K-components (K≤6) of six J→J+1 rotational transitions (J=6, 10, 17, 22, 31 and 33) of CH335Cl perturbed by O2 are measured at room temperature with Voigt, speed-dependent Voigt and Galatry profiles in order to probe the speed-dependence effects. With respect to the previous study of CH335Cl-N2 system [Guinet et al., J Quant Spectrosc Radiat Transfer 2012;113:1113], higher active-gas pressures are reached, providing better signal-to-noise ratios, and the exact expression of the Beer-Lambert law is introduced in the fitting procedure, leading, among other advantages, to much more realistic low-pressure results. The broadening parameters of the considered lines are also computed by a semi-classical method for various relative velocities of colliders and the powers characterizing the dependence of the collisional cross-sections on relative speeds are deduced as functions of the rotational numbers J and K. Additional calculations performed with the Maxwell-Boltzmann distribution of velocities show no significant difference with the earlier results [Buldyreva et al., Phys Chem Chem Phys 2011;13:20326] obtained within the mean thermal velocity approximation. Weighted sums of the presently measured Voigt-profile O2-broadening parameters and of the previously published N2-broadening ones are calculated to yield experimental air-broadening coefficients for spectroscopic databases.

A transfer function type of simplified electrochemical model with modified boundary conditions and Padé approximation for Li-ion battery: Part 2. Modeling and parameter estimation

NASA Astrophysics Data System (ADS)

Yuan, Shifei; Jiang, Lei; Yin, Chengliang; Wu, Hongjie; Zhang, Xi

2017-06-01

The electrochemistry-based battery model can provide physics-meaningful knowledge about the lithium-ion battery system with extensive computation burdens. To motivate the development of reduced order battery model, three major contributions have been made throughout this paper: (1) the transfer function type of simplified electrochemical model is proposed to address the current-voltage relationship with Padé approximation method and modified boundary conditions for electrolyte diffusion equations. The model performance has been verified under pulse charge/discharge and dynamic stress test (DST) profiles with the standard derivation less than 0.021 V and the runtime 50 times faster. (2) the parametric relationship between the equivalent circuit model and simplified electrochemical model has been established, which will enhance the comprehension level of two models with more in-depth physical significance and provide new methods for electrochemical model parameter estimation. (3) four simplified electrochemical model parameters: equivalent resistance Req, effective diffusion coefficient in electrolyte phase Deeff, electrolyte phase volume fraction ε and open circuit voltage (OCV), have been identified by the recursive least square (RLS) algorithm with the modified DST profiles under 45, 25 and 0 °C. The simulation results indicate that the proposed model coupled with RLS algorithm can achieve high accuracy for electrochemical parameter identification in dynamic scenarios.

Fabrication Equipment for Periodic Material Assemblies and Ph Assemblies and Photonic Crystals (DURIP FY06)

DTIC Science & Technology

2008-04-29

An exhaust hood is necessary for binder removal. Cooling requires a fan at a second speed setpoint . Firing profiles need to be precisely...29,935.06 from Ohio match. Plasmalab 80 Plus Compact etching system (left) and heater/ chiller unit (right). CAHN TherMax 500 High Pressure TGA...the current research is aimed to optimize parameters of the structure, in order to improve the resonant properties of the periodic layered structures

Study the effect of chemical reaction and variable viscosity on free convection MHD radiating flow over an inclined plate bounded by porous medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ali, M., E-mail: ali.mehidi93@gmail.com; Department of Mathematics, Chittagong University of Engineering and Technology, Chittagong-4349; Alim, M. A., E-mail: maalim@math.buet.ac.bd

An analysis is performed to study the free convection heat and mass transfer flow of an electrically conducting incompressible viscous fluid about a semi-infinite inclined porous plate under the action of radiation, chemical reaction in presence of magnetic field with variable viscosity. The dimensionless governing equations are steady, two-dimensional coupled and non-linear ordinary differential equation. Nachtsgeim-Swigert shooting iteration technique along with Runge-Kutta integration scheme is used to solve the non-dimensional governing equations. The effects of magnetic parameter, viscosity parameter and chemical reaction parameter on velocity, temperature and concentration profiles are discussed numerically and shown graphically. Therefore, the results of velocitymore » profile decreases for increasing values of magnetic parameter and viscosity parameter but there is no effect for reaction parameter. The temperature profile decreases in presence of magnetic parameter, viscosity parameter and Prandtl number but increases for radiation parameter. Also, concentration profile decreases for the increasing values of magnetic parameter, viscosity parameter and reaction parameter. All numerical calculations are done with respect to salt water and fixed angle of inclination of the plate.« less

Reparameterization of All-Atom Dipalmitoylphosphatidylcholine Lipid Parameters Enables Simulation of Fluid Bilayers at Zero Tension

PubMed Central

Sonne, Jacob; Jensen, Morten Ø.; Hansen, Flemming Y.; Hemmingsen, Lars; Peters, Günther H.

2007-01-01

Molecular dynamics simulations of dipalmitoylphosphatidylcholine (DPPC) lipid bilayers using the CHARMM27 force field in the tensionless isothermal-isobaric (NPT) ensemble give highly ordered, gel-like bilayers with an area per lipid of ∼48 Å2. To obtain fluid (Lα) phase properties of DPPC bilayers represented by the CHARMM energy function in this ensemble, we reparameterized the atomic partial charges in the lipid headgroup and upper parts of the acyl chains. The new charges were determined from the electron structure using both the Mulliken method and the restricted electrostatic potential fitting method. We tested the derived charges in molecular dynamics simulations of a fully hydrated DPPC bilayer. Only the simulation with the new restricted electrostatic potential charges shows significant improvements compared with simulations using the original CHARMM27 force field resulting in an area per lipid of 60.4 ± 0.1 Å2. Compared to the 48 Å2, the new value of 60.4 Å2 is in fair agreement with the experimental value of 64 Å2. In addition, the simulated order parameter profile and electron density profile are in satisfactory agreement with experimental data. Thus, the biologically more interesting fluid phase of DPPC bilayers can now be simulated in all-atom simulations in the NPT ensemble by employing our modified CHARMM27 force field. PMID:17400696

Synthesis of dynamic phase profile by the correlation technique for spatial control of optical beams in multiplexing and switching

NASA Astrophysics Data System (ADS)

Bugaychuk, Svitlana A.; Gnatovskyy, Vladimir O.; Sidorenko, Andrey V.; Pryadko, Igor I.; Negriyko, Anatoliy M.

2015-11-01

New approach for the correlation technique, which is based on multiple periodic structures to create a controllable angular spectrum, is proposed and investigated both theoretically and experimentally. The transformation of an initial laser beam occurs due to the actions of consecutive phase periodic structures, which may differ by their parameters. Then, after the Fourier transformation of a complex diffraction field, the output diffraction orders will be changed both by their intensities and by their spatial position. The controllable change of output angular spectrum is carried out by a simple control of the parameters of the periodic structures. We investigate several simple examples of such management.

Study of the Effects of Impurities on the Properties of Silicon Materials and Performance of Silicon Solar Cell

NASA Technical Reports Server (NTRS)

Sah, C. T.

1979-01-01

Numerical solutions were obtained from the exact one dimensional transmission line circuit model to study the following effects on the terrestrial performance of silicon solar cells: interband Auger recombination; surface recombination at the contact interfaces; enhanced metallic impurity solubility; diffusion profiles; and defect-impurity recombination centers. Thermal recombination parameters of titanium impurity in silicon were estimated from recent experimental data. Based on those parameters, computer model calculations showed that titanium concentration must be kept below 6x10 to the 12th power Ti/cu cm in order to achieve 16% AM1 efficiency in a silicon solar cell of 250 micrometers thick and 1.5 ohm-cm resistivity.

Hyperspectral scattering profiles for prediction of the microbial spoilage of beef

NASA Astrophysics Data System (ADS)

Peng, Yankun; Zhang, Jing; Wu, Jianhu; Hang, Hui

2009-05-01

Spoilage in beef is the result of decomposition and the formation of metabolites caused by the growth and enzymatic activity of microorganisms. There is still no technology for the rapid, accurate and non-destructive detection of bacterially spoiled or contaminated beef. In this study, hyperspectral imaging technique was exploited to measure biochemical changes within the fresh beef. Fresh beef rump steaks were purchased from a commercial plant, and left to spoil in refrigerator at 8°C. Every 12 hours, hyperspectral scattering profiles over the spectral region between 400 nm and 1100 nm were collected directly from the sample surface in reflection pattern in order to develop an optimal model for prediction of the beef spoilage, in parallel the total viable count (TVC) per gram of beef were obtained by classical microbiological plating methods. The spectral scattering profiles at individual wavelengths were fitted accurately by a two-parameter Lorentzian distribution function. TVC prediction models were developed, using multi-linear regression, on relating individual Lorentzian parameters and their combinations at different wavelengths to log10(TVC) value. The best predictions were obtained with r2= 0.96 and SEP = 0.23 for log10(TVC). The research demonstrated that hyperspectral imaging technique is a valid tool for real-time and non-destructive detection of bacterial spoilage in beef.

Constraining the Structure of Hot Jupiter Atmospheres Using a Hybrid Version of the NEMESIS Retrieval Algorithm

NASA Astrophysics Data System (ADS)

Badhan, Mahmuda A.; Mandell, Avi M.; Hesman, Brigette; Nixon, Conor; Deming, Drake; Irwin, Patrick; Barstow, Joanna; Garland, Ryan

2015-11-01

Understanding the formation environments and evolution scenarios of planets in nearby planetary systems requires robust measures for constraining their atmospheric physical properties. Here we have utilized a combination of two different parameter retrieval approaches, Optimal Estimation and Markov Chain Monte Carlo, as part of the well-validated NEMESIS atmospheric retrieval code, to infer a range of temperature profiles and molecular abundances of H2O, CO2, CH4 and CO from available dayside thermal emission observations of several hot-Jupiter candidates. In order to keep the number of parameters low and henceforth retrieve more plausible profile shapes, we have used a parametrized form of the temperature profile based upon an analytic radiative equilibrium derivation in Guillot et al. 2010 (Line et al. 2012, 2014). We show retrieval results on published spectroscopic and photometric data from both the Hubble Space Telescope and Spitzer missions, and compare them with simulations from the upcoming JWST mission. In addition, since NEMESIS utilizes correlated distribution of absorption coefficients (k-distribution) amongst atmospheric layers to compute these models, updates to spectroscopic databases can impact retrievals quite significantly for such high-temperature atmospheres. As high-temperature line databases are continually being improved, we also compare retrievals between old and newer databases.

Numerical modelling on pulsatile flow of Casson nanofluid through an inclined artery with stenosis and tapering under the influence of magnetic field and periodic body acceleration

NASA Astrophysics Data System (ADS)

Ponalagusamy, R.; Priyadharshini, S.

2017-11-01

The present study investigates the pulsatile flow of Casson nanofluid through an inclined and stenosed artery with tapering in the presence of magnetic field and periodic body acceleration. The iron oxide nanoparticles are allowed to flow along with it. The governing equations for the flow of Casson fluid when the artery is tapered slightly having mild stenosis are highly non-linear and the momentum equations for temperature and concentration are coupled and are solved using finite difference numerical schemes in order to find the solutions for velocity, temperature, concentration, wall shear stress, and resistance to blood flow. The aim of the present study is to analyze the effects of flow parameters on the flow of nanofluid through an inclined arterial stenosis with tapering. These effects are represented graphically and concluded that the wall shear stress profiles enhance with increase in yield stress, magnetic field, thermophoresis parameter and decreases with Brownian motion parameter, local temperature Grashof number, local nanoparticle Grashof number. The significance of the model is the existence of yield stress and it is examined that when the rheology of blood changes from Newtonian to Casson fluid, the percentage of decrease in the flow resistance is higher with respect to the increase in the parameters local temperature Grashof number, local nanoparticle Grashof number, Brownian motion parameter, and Prandtl number. It is pertinent to observe that increase in the Brownian motion parameter leads to increment in concentration and temperature profiles. It is observed that the concentration of nanoparticles decreases with increase in the value of thermophoresis parameter.

On mantle heterogeneity and anisotropy as mapped by inversion of global surface wave data

NASA Astrophysics Data System (ADS)

Khan, A.; Boschi, L.; Connolly, J.; Deschamps, F.

2008-12-01

We jointly invert Love and Rayleigh wave dispersion curves for the Earth's mantle composition, thermal state, P and S wave anisotropy at different locations on the Earth, based on self-consistent thermodynamic calculations. The method consists of four parts: 1. The composition of the Earth is modeled by the chemical system CaO-FeO-MgO- Al2O3-SiO2. Given these parameters and a geotherm (also an unknown), we calculate stable mineral modes, elastic properties, bulk density at the prevailing physical conditions using Gibbs free energy minimisation. Voigt-Reuss-Hill averaging is subsequently emplouyed to compute radial isotropic P and S wave velocity profiles in the elastic limit. 2. Anisotropic P and S wave velocities are determined from the isotropic ones by employing the relations ξ=(Vsh/Vsv)2, φ = (Vpv/Vph)2, η=F/(2A-L), Vs=(2Vsv2+Vsh2)/3 and Vp=(Vpv2+4Vph2)/5. The former three parameters are the standard anisotropy parameters, that we also invert for. 4. From these radial profiles, i.e. of Vsv, Vsh, Vph, Vpv and ρ, sunthetic Love and Rayleigh wave dispersion curves are calculated. The dispersion curves, which comprise fundamental and overtones up to 5th (Love) and 6th (Rayleigh) order have been extracted from global surface wave velocity maps. Given the above scheme, the data are at each location are jointly inverted using a Markov Chain Monte Carlo algorithm, from which a range of compositions, temperatures and radial profiles of anisotropy parameters, fitting data within uncertainties, are obtained. Our method has several advantages over standard approaches, in that no scaling relationships between Vs and Vp and ρ and Vs have to be introduced, implying that the full sensitivity of Rayleigh and Love waves to the parameters Vs, Vp and ρ is accounted for. In this particular study we investigate 5 locations distributed across the globe and reveal mantle chemical and thermal differences at these locations.

Kinetic rate laws of Cd, Pb, and Zn vaporization during municipal solid waste incineration.

PubMed

Falcoz, Quentin; Gauthier, Daniel; Abanades, Stéphane; Flamant, Gilles; Patisson, Fabrice

2009-03-15

The kinetic rate laws of heavy metal (HM) vaporization from municipal solid waste during its incineration were studied. Realistic artificial waste (RAW) samples spiked with Pb, Zn, and Cd were injected into a fluidized bed reactor. Metal vaporization wastracked by continuous measure ofthe above metals in exhaust gases. An inverse model of the reactor was used to calculate the metal vaporization rates from the concentration vs time profiles in the outlet gas. For each metal, experiments were carried out at several temperatures in order to determine the kinetic parameters and to obtain specific rate laws as functions of temperature. Temperature has a strong influence on the HM vaporization dynamics, especially on the vaporization kinetics profile. This phenomenon was attributed to internal diffusion control of the HM release. Two types of kinetic rate laws were established based on temperature: a fourth- or fifth-order polynomial rate law (r(x) = k0e(-E(A)/RT)p(x)) for temperatures lower than 740 degrees C and a first-order polynomial (r(x) = k0e(-E(A)/ RT(q-q(f) for temperatures higher than 740 degrees C.

Numerical modeling of materials processing applications of a pulsed cold cathode electron gun

NASA Astrophysics Data System (ADS)

Etcheverry, J. I.; Martínez, O. E.; Mingolo, N.

1998-04-01

A numerical study of the application of a pulsed cold cathode electron gun to materials processing is performed. A simple semiempirical model of the discharge is used, together with backscattering and energy deposition profiles obtained by a Monte Carlo technique, in order to evaluate the energy source term inside the material. The numerical computation of the heat equation with the calculated source term is performed in order to obtain useful information on melting and vaporization thresholds, melted radius and depth, and on the dependence of these variables on processing parameters such as operating pressure, initial voltage of the discharge and cathode-sample distance. Numerical results for stainless steel are presented, which demonstrate the need for several modifications of the experimental design in order to achieve a better efficiency.

Automatic genetic optimization approach to two-dimensional blade profile design for steam turbines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trigg, M.A.; Tubby, G.R.; Sheard, A.G.

1999-01-01

In this paper a systematic approach to the optimization of two-dimensional blade profiles is presented. A genetic optimizer has been developed that modifies the blade profile and calculates its profile loss. This process is automatic, producing profile designs significantly faster and with significantly lower loss than has previously been possible. The optimizer developed uses a genetic algorithm to optimize a two-dimensional profile, defined using 17 parameters, for minimum loss with a given flow condition. The optimizer works with a population of two-dimensional profiles with varied parameters. A CFD mesh is generated for each profile, and the result is analyzed usingmore » a two-dimensional blade-to-blade solver, written for steady viscous compressible flow, to determine profile loss. The loss is used as the measure of a profile`s fitness. The optimizer uses this information to select the members of the next population, applying crossovers, mutations, and elitism in the process. Using this method, the optimizer tends toward the best values for the parameters defining the profile with minimum loss.« less

Geometry modeling of single track cladding deposited by high power diode laser with rectangular beam spot

NASA Astrophysics Data System (ADS)

Liu, Huaming; Qin, Xunpeng; Huang, Song; Hu, Zeqi; Ni, Mao

2018-01-01

This paper presents an investigation on the relationship between the process parameters and geometrical characteristics of the sectional profile for the single track cladding (STC) deposited by High Power Diode Laser (HPDL) with rectangle beam spot (RBS). To obtain the geometry parameters, namely cladding width Wc and height Hc of the sectional profile, a full factorial design (FFD) of experiment was used to conduct the experiments with a total of 27. The pre-placed powder technique has been employed during laser cladding. The influence of the process parameters including laser power, powder thickness and scanning speed on the Wc and Hc was analyzed in detail. A nonlinear fitting model was used to fit the relationship between the process parameters and geometry parameters. And a circular arc was adopted to describe the geometry profile of the cross-section of STC. The above models were confirmed by all the experiments. The results indicated that the geometrical characteristics of the sectional profile of STC can be described as the circular arc, and the other geometry parameters of the sectional profile can be calculated only using Wc and Hc. Meanwhile, the Wc and Hc can be predicted through the process parameters.

The position profiles of order cancellations in an emerging stock market

NASA Astrophysics Data System (ADS)

Gu, Gao-Feng; Xiong, Xiong; Ren, Fei; Zhou, Wei-Xing; Zhang, Wei

2013-04-01

Order submission and cancellation are two constituent actions of stock trading behaviors in order-driven markets. Order submission dynamics has been extensively studied for different markets, while order cancellation dynamics is less understood. There are two positions associated with a cancellation, that is, the price level in the limit-order book (LOB) and the position in the queue at each price level. We study the profiles of these two order cancellation positions through rebuilding the limit-order book using the order flow data of 23 liquid stocks traded on the Shenzhen Stock Exchange in the year 2003. We find that the profiles of relative price levels where cancellations occur obey a log-normal distribution. After normalizing the relative price level by removing the factor of order numbers stored at the price level, we find that the profiles exhibit a power-law scaling behavior on the right tails for both buy and sell orders. When focusing on the order cancellation positions in the queue at each price level, we find that the profiles increase rapidly in the front of the queue, and then fluctuate around a constant value till the end of the queue. These profiles are similar for different stocks. In addition, the profiles of cancellation positions can be fitted by an exponent function for both buy and sell orders. These two kinds of cancellation profiles seem universal for different stocks investigated and exhibit minor asymmetry between buy and sell orders. Our empirical findings shed new light on the order cancellation dynamics and pose constraints on the construction of order-driven stock market models.

Developing a methodology for the inverse estimation of root architectural parameters from field based sampling schemes

NASA Astrophysics Data System (ADS)

Morandage, Shehan; Schnepf, Andrea; Vanderborght, Jan; Javaux, Mathieu; Leitner, Daniel; Laloy, Eric; Vereecken, Harry

2017-04-01

Root traits are increasingly important in breading of new crop varieties. E.g., longer and fewer lateral roots are suggested to improve drought resistance of wheat. Thus, detailed root architectural parameters are important. However, classical field sampling of roots only provides more aggregated information such as root length density (coring), root counts per area (trenches) or root arrival curves at certain depths (rhizotubes). We investigate the possibility of obtaining the information about root system architecture of plants using field based classical root sampling schemes, based on sensitivity analysis and inverse parameter estimation. This methodology was developed based on a virtual experiment where a root architectural model was used to simulate root system development in a field, parameterized for winter wheat. This information provided the ground truth which is normally unknown in a real field experiment. The three sampling schemes coring, trenching, and rhizotubes where virtually applied to and aggregated information computed. Morris OAT global sensitivity analysis method was then performed to determine the most sensitive parameters of root architecture model for the three different sampling methods. The estimated means and the standard deviation of elementary effects of a total number of 37 parameters were evaluated. Upper and lower bounds of the parameters were obtained based on literature and published data of winter wheat root architectural parameters. Root length density profiles of coring, arrival curve characteristics observed in rhizotubes, and root counts in grids of trench profile method were evaluated statistically to investigate the influence of each parameter using five different error functions. Number of branches, insertion angle inter-nodal distance, and elongation rates are the most sensitive parameters and the parameter sensitivity varies slightly with the depth. Most parameters and their interaction with the other parameters show highly nonlinear effect to the model output. The most sensitive parameters will be subject to inverse estimation from the virtual field sampling data using DREAMzs algorithm. The estimated parameters can then be compared with the ground truth in order to determine the suitability of the sampling schemes to identify specific traits or parameters of the root growth model.

Glucose ameliorates the metabolic profile and mitochondrial function of platelet concentrates during storage in autologous plasma

PubMed Central

Amorini, Angela M.; Tuttobene, Michele; Tomasello, Flora M.; Biazzo, Filomena; Gullotta, Stefano; De Pinto, Vito; Lazzarino, Giuseppe; Tavazzi, Barbara

2013-01-01

Background It is essential that the quality of platelet metabolism and function remains high during storage in order to ensure the clinical effectiveness of a platelet transfusion. New storage conditions and additives are constantly evaluated in order to achieve this. Using glucose as a substrate is controversial because of its potential connection with increased lactate production and decreased pH, both parameters triggering the platelet lesion during storage. Materials and methods In this study, we analysed the morphological status and metabolic profile of platelets stored for various periods in autologous plasma enriched with increasing glucose concentrations (13.75, 27.5 and 55 mM). After 0, 2, 4, 6 and 8 days, high energy phosphates (ATP, GTP, ADP, AMP), oxypurines (hypoxanthine, xanthine, uric acid), lactate, pH, mitochondrial function, cell lysis and morphology, were evaluated. Results The data showed a significant dose-dependent improvement of the different parameters in platelets stored with increasing glucose, compared to what detected in controls. Interestingly, this phenomenon was more marked at the highest level of glucose tested and in the period of time generally used for platelet transfusion (0–6 days). Conclusion These results indicate that the addition of glucose during platelet storage ameliorates, in a dose-dependent manner, the biochemical parameters related to energy metabolism and mitochondrial function. Since there was no correspondence between glucose addition, lactate increase and pH decrease in our experiments, it is conceivable that platelet derangement during storage is not directly caused by glucose through an increase of anaerobic glycolysis, but rather to a loss of mitochondrial functions caused by reduced substrate availability. PMID:22682337

[Measurement of atomic number of alkali vapor and pressure of buffer gas based on atomic absorption].

PubMed

Zheng, Hui-jie; Quan, Wei; Liu, Xiang; Chen, Yao; Lu, Ji-xi

2015-02-01

High sensitivitymagnetic measurementscanbe achieved by utilizing atomic spinmanipulation in the spin-exchange-relaxation-free (SERF) regime, which uses an alkali cell as a sensing element. The atomic number density of the alkali vapor and the pressure of the buffer gasare among the most important parameters of the cell andrequire accurate measurement. A method has been proposed and developedto measure the atomic number density and the pressure based on absorption spectroscopy, by sweeping the absorption line and fittingthe experiment data with a Lorentzian profile to obtainboth parameters. Due to Doppler broadening and pressure broadening, which is mainly dominated by the temperature of the cell and the pressure of buffer gas respectively, this work demonstrates a simulation of the errorbetween the peaks of the Lorentzian profile and the Voigt profile caused by bothfactors. The results indicates that the Doppler broadening contribution is insignificant with an error less than 0.015% at 313-513 K for a 4He density of 2 amg, and an error of 0.1% in the presence of 0.6-5 amg at 393 K. We conclude that the Doppler broadening could be ignored under above conditions, and that the Lorentzianprofile is suitably applied to fit the absorption spectrumobtainingboth parameters simultaneously. In addition we discuss the resolution and the instability due to thelight source, wavelength and the temperature of the cell. We find that the cell temperature, whose uncertainty is two orders of magnitude larger than the instability of the light source and the wavelength, is one of the main factors which contributes to the error.

Spectral Analysis and Metastable Absorption Measurements of High Pressure Capacitively and Inductively Coupled Radio-Frequency Argon-Helium Discharges

DTIC Science & Technology

2013-06-01

density of the s5 and s3 metastable states for different discharge parameters. The absorption data was fit to an approximated Voigt profile from which...pressures are required in order to have enough spin-orbit relaxation to maintain CW lasing without significant bottlenecking. There are many methods to...for just that [(5),(12)]. This method allows for a wide study of energy levels since the limiting factor is the sensitivity of the detector and modern

General solution of a fractional Parker diffusion-convection equation describing the superdiffusive transport of energetic particles

NASA Astrophysics Data System (ADS)

Tawfik, Ashraf M.; Fichtner, Horst; Elhanbaly, A.; Schlickeiser, Reinhard

2018-06-01

Anomalous diffusion models of energetic particles in space plasmas are developed by introducing the fractional Parker diffusion-convection equation. Analytical solution of the space-time fractional equation is obtained by use of the Caputo and Riesz-Feller fractional derivatives with the Laplace-Fourier transforms. The solution is given in terms of the Fox H-function. Profiles of particle densities are illustrated for different values of the space fractional order and the so-called skewness parameter.

Copula-based analysis of rhythm

NASA Astrophysics Data System (ADS)

García, J. E.; González-López, V. A.; Viola, M. L. Lanfredi

2016-06-01

In this paper we establish stochastic profiles of the rhythm for three languages: English, Japanese and Spanish. We model the increase or decrease of the acoustical energy, collected into three bands coming from the acoustic signal. The number of parameters needed to specify a discrete multivariate Markov chain grows exponentially with the order and dimension of the chain. In this case the size of the database is not large enough for a consistent estimation of the model. We apply a strategy to estimate a multivariate process with an order greater than the order achieved using standard procedures. The new strategy consist on obtaining a partition of the state space which is constructed from a combination of the partitions corresponding to the three marginal processes, one for each band of energy, and the partition coming from to the multivariate Markov chain. Then, all the partitions are linked using a copula, in order to estimate the transition probabilities.

Optimizing the Determination of Roughness Parameters for Model Urban Canopies

NASA Astrophysics Data System (ADS)

Huq, Pablo; Rahman, Auvi

2018-05-01

We present an objective optimization procedure to determine the roughness parameters for very rough boundary-layer flow over model urban canopies. For neutral stratification the mean velocity profile above a model urban canopy is described by the logarithmic law together with the set of roughness parameters of displacement height d, roughness length z_0 , and friction velocity u_* . Traditionally, values of these roughness parameters are obtained by fitting the logarithmic law through (all) the data points comprising the velocity profile. The new procedure generates unique velocity profiles from subsets or combinations of the data points of the original velocity profile, after which all possible profiles are examined. Each of the generated profiles is fitted to the logarithmic law for a sequence of values of d, with the representative value of d obtained from the minima of the summed least-squares errors for all the generated profiles. The representative values of z_0 and u_* are identified by the peak in the bivariate histogram of z_0 and u_* . The methodology has been verified against laboratory datasets of flow above model urban canopies.

Design of crossed planar phase grating for metrology

NASA Astrophysics Data System (ADS)

Tang, Yu; Chen, Xinrong; Li, Chaoming; Wang, Rui; Xu, Haiyan; Cheng, Yushui

2018-01-01

Crossed-grating is widely used as the standard element for metrology in two-dimensional precision positioning system. It has many advantages such as high resolution, compact structure, good environmental adaptability and less Abbe error. In this paper, the design of crossed planar reflecting phase grating used under the Littrow condition with circularly polarized light at 780nm wavelength has been carried out. The aim of the design is to find out the range of structure parameters of crossed-grating that has higher -1st order diffraction efficiency and good efficiency equilibrium for both of TE- and TM-polarized incident lights. By adoption of the Fourier modal method (FMM), the microstructure parameters of the 1200lines/mm crossed grating with the duty cycle range of 10% to 50% and the profile depth of 150nm to 350nm have been searched exactly. The calculation results show that: When the duty cycle range of the grating is 42% to 44% and profile depth is 210nm to 220nm, the -1st diffraction efficiencies of TE- and TM-polarized lights are both above 60% and the efficiency equilibrium is better than 80%.

Timing irregularities of PSR J1705-1906

NASA Astrophysics Data System (ADS)

Liu, Y. L.; Yuan, J. P.; Wang, J. B.; Liu, X. W.; Wang, N.; Yuen, R.

2018-05-01

Timing analysis of PSR J1705-1906 using data from Nanshan 25-m and Parkes 64-m radio telescopes, which span over fourteen years, shows that the pulsar exhibits significant proper motion, and rotation instability. We updated the astrometry parameters and the spin parameters of the pulsar. In order to minimize the effect of timing irregularities on measuring its position, we employ the Cholesky method to analyse the timing noise. We obtain the proper motion of -77(3) mas yr-1 in right ascension and -38(29) mas yr-1 in declination. The power spectrum of timing noise is analyzed for the first time, which gives the spectral exponent α =-5.2 for the power-law model indicating that the fluctuations in spin frequency and spin-down rate dominate the red noise. We detect two small glitches from this pulsar with fractional jump in spin frequency of Δ ν /ν ˜ 2.9 × 10^{-10} around MJD 55199 and Δ ν /ν ˜ 2.7× 10^{-10} around MJD 55953. Investigations of pulse profile at different time segments suggest no significant changes in the pulse profiles around the two glitches.

Dual-Gate Modulation of Carrier Density and Disorder in an Oxide Two-Dimensional Electron System

DOE PAGES

Chen, Zhuoyu; Yuan, Hongtao; Xie, Yanwu; ...

2016-09-08

Carrier density and disorder are two crucial parameters that control the properties of correlated two-dimensional electron systems. Furthermore, in order to disentangle their individual contributions to quantum phenomena, independent tuning of these two parameters is required. By utilizing a hybrid liquid/solid electric dual-gate geometry acting on the conducting LaAlO 3/SrTiO 3 heterointerface, we obtain an additional degree of freedom to strongly modify the electron confinement profile and thus the strength of interfacial scattering, independent from the carrier density. A dual-gate controlled nonlinear Hall effect is a direct manifestation of this profile, which can be quantitatively understood by a Poisson–Schrödinger sub-bandmore » model. In particular, the large nonlinear dielectric response of SrTiO 3 enables a very wide range of tunable density and disorder, far beyond that for conventional semiconductors. This study provides a broad framework for understanding various reported phenomena at the LaAlO 3/SrTiO 3 interface.« less

Image Tiling for Profiling Large Objects

NASA Technical Reports Server (NTRS)

Venkataraman, Ajit; Schock, Harold; Mercer, Carolyn R.

1992-01-01

Three dimensional surface measurements of large objects arc required in a variety of industrial processes. The nature of these measurements is changing as optical instruments arc beginning to replace conventional contact probes scanned over the objects. A common characteristic of the optical surface profilers is the trade off between measurement accuracy and field of view. In order to measure a large object with high accuracy, multiple views arc required. An accurate transformation between the different views is needed to bring about their registration. In this paper, we demonstrate how the transformation parameters can be obtained precisely by choosing control points which lie in the overlapping regions of the images. A good starting point for the transformation parameters is obtained by having a knowledge of the scanner position. The selection of the control points arc independent of the object geometry. By successively recording multiple views and obtaining transformation with respect to a single coordinate system, a complete physical model of an object can be obtained. Since all data arc in the same coordinate system, it can thus be used for building automatic models for free form surfaces.

Flow and heat transfer of nanofluid over a stretching sheet with non-linear velocity in the presence of thermal radiation and chemical reaction

NASA Astrophysics Data System (ADS)

Madaki, A. G.; Roslan, R.; Kandasamy, R.; Chowdhury, M. S. H.

2017-04-01

In this paper, the effects of Brownian motion, thermophoresis, chemical reaction, heat generation, magnetohydrodynamic and thermal radiation has been included in the model of nanofluid flow and heat transfer over a moving surface with variable thickness. The similarity transformation is used to transform the governing boundary layer equations into ordinary differential equations (ODE). Both optimal homotopy asymptotic method (OHAM) and Runge-Kutta fourth order method with shooting technique are employed to solve the resulting ODEs. For different values of the pertinent parameters on the velocity, temperature and concentration profiles have been studied and details are given in tables and graphs respectively. A comparison with the previous study is made, where an excellent agreement is achieved. The results demonstrate that the radiation parameter N increases, with the increase in both the temperature and the thermal boundary layer thickness respectively. While the nanoparticles concentration profiles increase with the influence of generative chemical reaction γ < 0, while it decreases with destructive chemical reaction γ > 0.

Surface roughness analysis after laser assisted machining of hard to cut materials

NASA Astrophysics Data System (ADS)

Przestacki, D.; Jankowiak, M.

2014-03-01

Metal matrix composites and Si3N4 ceramics are very attractive materials for various industry applications due to extremely high hardness and abrasive wear resistance. However because of these features they are problematic for the conventional turning process. The machining on a classic lathe still requires special polycrystalline diamond (PCD) or cubic boron nitride (CBN) cutting inserts which are very expensive. In the paper an experimental surface roughness analysis of laser assisted machining (LAM) for two tapes of hard-to-cut materials was presented. In LAM, the surface of work piece is heated directly by a laser beam in order to facilitate, the decohesion of material. Surface analysis concentrates on the influence of laser assisted machining on the surface quality of the silicon nitride ceramic Si3N4 and metal matrix composite (MMC). The effect of the laser assisted machining was compared to the conventional machining. The machining parameters influence on surface roughness parameters was also investigated. The 3D surface topographies were measured using optical surface profiler. The analysis of power spectrum density (PSD) roughness profile were analyzed.

An unsupervised technique for optimal feature selection in attribute profiles for spectral-spatial classification of hyperspectral images

NASA Astrophysics Data System (ADS)

Bhardwaj, Kaushal; Patra, Swarnajyoti

2018-04-01

Inclusion of spatial information along with spectral features play a significant role in classification of remote sensing images. Attribute profiles have already proved their ability to represent spatial information. In order to incorporate proper spatial information, multiple attributes are required and for each attribute large profiles need to be constructed by varying the filter parameter values within a wide range. Thus, the constructed profiles that represent spectral-spatial information of an hyperspectral image have huge dimension which leads to Hughes phenomenon and increases computational burden. To mitigate these problems, this work presents an unsupervised feature selection technique that selects a subset of filtered image from the constructed high dimensional multi-attribute profile which are sufficiently informative to discriminate well among classes. In this regard the proposed technique exploits genetic algorithms (GAs). The fitness function of GAs are defined in an unsupervised way with the help of mutual information. The effectiveness of the proposed technique is assessed using one-against-all support vector machine classifier. The experiments conducted on three hyperspectral data sets show the robustness of the proposed method in terms of computation time and classification accuracy.

Estimates of Shear Stress and Measurements of Water Levels in the Lower Fox River near Green Bay, Wisconsin

USGS Publications Warehouse

Westenbroek, Stephen M.

2006-01-01

Turbulent shear stress in the boundary layer of a natural river system largely controls the deposition and resuspension of sediment, as well as the longevity and effectiveness of granular-material caps used to cover and isolate contaminated sediments. This report documents measurements and calculations made in order to estimate shear stress and shear velocity on the Lower Fox River, Wisconsin. Velocity profiles were generated using an acoustic Doppler current profiler (ADCP) mounted on a moored vessel. This method of data collection yielded 158 velocity profiles on the Lower Fox River between June 2003 and November 2004. Of these profiles, 109 were classified as valid and were used to estimate the bottom shear stress and velocity using log-profile and turbulent kinetic energy methods. Estimated shear stress ranged from 0.09 to 10.8 dynes per centimeter squared. Estimated coefficients of friction ranged from 0.001 to 0.025. This report describes both the field and data-analysis methods used to estimate shear-stress parameters for the Lower Fox River. Summaries of the estimated values for bottom shear stress, shear velocity, and coefficient of friction are presented. Confidence intervals about the shear-stress estimates are provided.

Satellite radio occultation investigations of internal gravity waves in the planetary atmospheres

NASA Astrophysics Data System (ADS)

Kirillovich, Ivan; Gubenko, Vladimir; Pavelyev, Alexander

Internal gravity waves (IGWs) modulate the structure and circulation of the Earth’s atmosphere, producing quasi-periodic variations in the wind velocity, temperature and density. Similar effects are anticipated for the Venus and Mars since IGWs are a characteristic of stably stratified atmosphere. In this context, an original method for the determination of IGW parameters from a vertical temperature profile measurement in a planetary atmosphere has been developed [Gubenko et al., 2008, 2011, 2012]. This method does not require any additional information not contained in the profile and may be used for the analysis of profiles measured by various techniques. The criterion for the IGW identification has been formulated and argued. In the case when this criterion is satisfied, the analyzed temperature fluctuations can be considered as wave-induced. The method is based on the analysis of relative amplitudes of the wave field and on the linear IGW saturation theory in which these amplitudes are restricted by dynamical (shear) instability processes in the atmosphere. When the amplitude of an internal wave reaches the shear instability threshold, energy is assumed to be dissipated in such a way that the IGW amplitude is maintained at the instability threshold level as the wave propagates upwards. We have extended the developed technique [Gubenko et al., 2008] in order to reconstruct the complete set of wave characteristics including such important parameters as the wave kinetic and potential energy per unit mass and IGW fluxes of the energy and horizontal momentum [Gubenko et al., 2011]. We propose also an alternative method to estimate the relative amplitudes and to extract IGW parameters from an analysis of perturbations of the Brunt-Vaislala frequency squared [Gubenko et al., 2011]. An application of the developed method to the radio occultation (RO) temperature data has given the possibility to identify the IGWs in the Earth's, Martian and Venusian atmospheres and to determine the magnitudes of key wave parameters such as the intrinsic frequency, amplitudes of vertical and horizontal wind velocity perturbations, vertical and horizontal wavelengths, intrinsic vertical and horizontal phase (and group) speeds, kinetic and potential energy per unit mass, vertical fluxes of the wave energy and horizontal momentum. Vertical profiles of temperature retrieved from RO measurements of the CHAMP (Earth), Mars Global Surveyor (Mars), Magellan and Venus Express (Venus) missions are used and analyzed to identify discrete or “narrow spectral” wave events and to determine IGW characteristics in the Earth’s, Martian and Venusian atmospheres. This work was partially supported by the RFBR grant 13-02-00526-a and Program 22 of the RAS Presidium. References. Gubenko V.N., Pavelyev A.G., Andreev V.E. Determination of the intrinsic frequency and other wave parameters from a single vertical temperature or density profile measurement // J. Geophys. Res. 2008. V. 113. No.D08109, doi:10.1029/2007JD008920. Gubenko V.N., Pavelyev A.G., Salimzyanov R.R., Pavelyev A.A. Reconstruction of internal gravity wave parameters from radio occultation retrievals of vertical temperature profiles in the Earth’s atmosphere // Atmos. Meas. Tech. 2011. V. 4. No.10. P. 2153-2162, doi:10.5194/amt-4-2153-2011. Gubenko V.N., Pavelyev A.G., Salimzyanov R.R., Andreev V.E. A method for determination of internal gravity wave parameters from a vertical temperature or density profile measurement in the Earth’s atmosphere // Cosmic Res. 2012. V. 50. No.1. P. 21-31, doi: 10.1134/S0010952512010029.

A case study on the in silico absorption simulations of levothyroxine sodium immediate-release tablets.

PubMed

Kocic, Ivana; Homsek, Irena; Dacevic, Mirjana; Grbic, Sandra; Parojcic, Jelena; Vucicevic, Katarina; Prostran, Milica; Miljkovic, Branislava

2012-04-01

The aim of this case study was to develop a drug-specific absorption model for levothyroxine (LT4) using mechanistic gastrointestinal simulation technology (GIST) implemented in the GastroPlus™ software package. The required input parameters were determined experimentally, in silico predicted and/or taken from the literature. The simulated plasma profile was similar and in a good agreement with the data observed in the in vivo bioequivalence study, indicating that the GIST model gave an accurate prediction of LT4 oral absorption. Additionally, plasma concentration-time profiles were simulated based on a set of experimental and virtual in vitro dissolution data in order to estimate the influence of different in vitro drug dissolution kinetics on the simulated plasma profiles and to identify biorelevant dissolution specification for LT4 immediate-release (IR) tablets. A set of experimental and virtual in vitro data was also used for correlation purposes. In vitro-in vivo correlation model based on the convolution approach was applied in order to assess the relationship between the in vitro and in vivo data. The obtained results suggest that dissolution specification of more than 85% LT4 dissolved in 60 min might be considered as biorelevant dissolution specification criteria for LT4 IR tablets. Copyright © 2012 John Wiley & Sons, Ltd.

Ice haze, snow, and the Mars water cycle

NASA Technical Reports Server (NTRS)

Kahn, Ralph

1990-01-01

Light curves and extinction profiles derived from Martian limb observations are used to constrain the atmospheric temperature structure in regions of the atmosphere with thin haze and to analyze the haze particle properties and atmospheric eddy mixing. Temperature between 170 and 190 K are obtained for three cases at levels in the atmosphere ranging from 20 to 50 km. Eddy diffusion coefficients around 100,000 sq cm/s, typical of a nonconvecting atmosphere, are derived in the haze regions at times when the atmosphere is relatively clear of dust. This parameter apparently changes by more than three orders of magnitude with season and local conditions. The derived particle size parameter varies systematically by more than an order of magnitude with condensation level, in such a way that the characteristic fall time is always about one Martian day. Ice hazes provide a mechanism for scavenging water vapor in the thin Mars atmosphere and may play a key role in the seasonal cycle of water on Mars.

Simultaneous effects of coagulation and variable magnetic field on peristaltically induced motion of Jeffrey nanofluid containing gyrotactic microorganism.

PubMed

Bhatti, M M; Zeeshan, A; Ellahi, R

2017-03-01

In this article, simultaneous effects of coagulation (blood clot) and variable magnetic field on peristaltically induced motion of non-Newtonian Jeffrey nanofluid containing gyrotactic microorganism through an annulus have been studied. The effects of an endoscope also taken into consideration in our study as a special case. The governing flow problem is simplified by taking the approximation of long wavelength and creeping flow regime. The resulting highly coupled differential equations are solved analytically with the help of perturbation method and series solution have been presented up to second order approximation. The impact of all the sundry parameters is discussed for velocity profile, temperature profile, nanoparticle concentration profile, motile microorganism density profile, pressure rise and friction forces. Moreover, numerical integration is also used to evaluate the expressions for pressure rise and friction forces for outer tube and inner tube. It is found that velocity of a fluid diminishes near the walls due to the increment in the height of clot. However, the influence of magnetic field depicts opposite behavior near the walls. Copyright © 2016 Elsevier Inc. All rights reserved.

Study on airflow characteristics in the semi-closed irregular narrow flow channel

NASA Astrophysics Data System (ADS)

Jin, Yuzhen; Hu, Xiaodong; Zhu, Linhang; Hu, Xudong; Jin, Yingzi

2016-04-01

The air-jet loom is widely used in the textile industry. The interaction mechanism of airflow and yarn is not clear in such a narrow flow channel, the gas consumption is relatively large, the yarn motion is unstable and the weft insertion is often interrupted during the operation. In order to study the characteristics of the semi-closed flow field in profiled dents, the momentum conservation equation is modified and the model parameters and boundary conditions are set. Compared with the different r, the ratio of profiled dent's thickness and gap, the results show that the smaller the r is, the smaller the velocity fluctuations of the airflow is. When the angle of profiled dents α is close to zero, the diffusion of the airflow will be less. The experiment is also conducted to verify the result of the simulation with a high-speed camera and pressure sensor in profiled dents. The airflow characteristics in the semi-closed irregular narrow flow channel in the paper would provide the theoretical basis for optimizing the weft insertion process of the air-jet loom.

Quiet-Sun Connection between the C IV Resonance Lines and the Photospheric Magnetic Field

NASA Astrophysics Data System (ADS)

Brynildsen, Nils; Kjeldseth-Moe, Olav; Maltby, Per

1996-05-01

The quiet-Sun relation between the C iv resonance line parameters and the photospheric magnetic field is studied with a spatial resolution of 1" x 1". The material is ordered into groups according to the magnitude of the magnetic flux density, |B|, and conditional probabilities are calculated. We find that red shifted profiles with either high intensity, large Doppler shift, or large line broadening occupy an increasing fraction of the area when |B| increases. These results are contrasted by blueshifted profiles which indicate a slight decrease with increasing magnetic flux density. The similarity in the results obtained with magneto grams taken several hours before and after the UV data led us to suggest that the tendency for red shifted profiles to outnumber blueshifted profiles in quiet regions originates in the super-granular network. Suggestions regarding the origin of the redshift phenomenon are briefly confronted with the observations. It appears difficult to explain the observations with models based on continuous gas flows. However, a model containing Alfvén wave pulses traveling from the corona toward the transition region promises to be compatible with the observations.

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

PubMed

Feng, Yan; Mitchison, Timothy J; Bender, Andreas; Young, Daniel W; Tallarico, John A

2009-07-01

Multi-parameter phenotypic profiling of small molecules provides important insights into their mechanisms of action, as well as a systems level understanding of biological pathways and their responses to small molecule treatments. It therefore deserves more attention at an early step in the drug discovery pipeline. Here, we summarize the technologies that are currently in use for phenotypic profiling--including mRNA-, protein- and imaging-based multi-parameter profiling--in the drug discovery context. We think that an earlier integration of phenotypic profiling technologies, combined with effective experimental and in silico target identification approaches, can improve success rates of lead selection and optimization in the drug discovery process.

A FEM simulation study of the solid state hydrostatic extrusion of PMMA

NASA Astrophysics Data System (ADS)

Costa, André L. M.; Riffel, Douglas B.; Misiolek, Wojciech Z.; Valberg, Henry S.

2018-05-01

Solid state hydrostatic extrusion (SSHE) of polymers below glass transition temperature is used to obtain highly oriented structures. Experimental studies on the SSHE of polymethyl-methacrylate (PMMA) have been made since early eighties but there is no information on internal temperature, stress and strain distribution. In this work we have made 3D FEM simulations of SSHE of PMMA by using the commercial DEFORM package with experimental flow curves and thermal properties from literature. The initial temperature of tooling and workpiece was 90°C, ram speeds were 1.0 and 10.0 mm/min with extrusion ratio R = 3.0. For a comparative analysis, SSHE simulation of the AA7108 aluminum alloy at 400°C was also performed. These ranges of parameters were chosen in order to encompass the parameters found in previously mentioned experiments. The best correlation with experimental hydrostatic pressure was verified for a shear friction coefficient at the material-conical die interface m = 0.50. Force-displacement curve for PMMA presented a constitutive and thermal softening in contrast to a constant force curve for aluminum. The internal temperature in the deformation zone increased in a characteristic "owl's face" profile in contrast to quasi-constant profile of aluminum alloy. In both PMMA and aluminum the stress is hydrostatic inside the container, but the stress profiles are significantly different inside the deformation zone. As expected, the strain and strain-rate profiles are practically the same for the two materials, but the temperature profile has promoted slightly differences in material flow. The velocity gradient from center to surface is higher in PMMA than aluminum. It's supposed that during hydrostatic extrusion solid PMMA has a characteristic thermally-inducted mechanical behavior.

A study on the application of Fourier series in IMRT treatment planning.

PubMed

Almeida-Trinidad, R; Garnica-Garza, H M

2007-12-01

In intensity-modulated radiotherapy, a set of x-ray fluence profiles is iteratively adjusted until a desired absorbed dose distribution is obtained. The purpose of this article is to present a method that allows the optimization of fluence profiles based on the Fourier series decomposition of an initial approximation to the profile. The method has the advantage that a new fluence profile can be obtained in a precise and controlled way with the tuning of only two parameters, namely the phase of the sine and cosine terms of one of the Fourier components, in contrast to the point-by-point tuning of the profile. Also, because the method uses analytical functions, the resultant profiles do not exhibit numerical artifacts. A test case consisting of a mathematical phantom with a target wrapped around a critical structure is discussed to illustrate the algorithm. It is shown that the degree of conformality of the absorbed dose distribution can be tailored by varying the number of Fourier terms made available to the optimization algorithm. For the test case discussed here, it is shown that the number of Fourier terms to be modified depends on the number of radiation beams incident on the target but it is in general in the order of 10 terms.

The ratio of profile peak separations as a probe of pulsar radio-beam structure

NASA Astrophysics Data System (ADS)

Dyks, J.; Pierbattista, M.

2015-12-01

The known population of pulsars contains objects with four- and five-component profiles, for which the peak-to-peak separations between the inner and outer components can be measured. These Q- and M-type profiles can be interpreted as a result of sightline cut through a nested-cone beam, or through a set of azimuthal fan beams. We show that the ratio RW of the components' separations provides a useful measure of the beam shape, which is mostly independent of parameters that determine the beam scale and complicate interpretation of simpler profiles. In particular, the method does not depend on the emission altitude and the dipole tilt distribution. The different structures of the radio beam imply manifestly different statistical distributions of RW, with the conal model being several orders of magnitude less consistent with data than the fan-beam model. To bring the conal model into consistency with data, strong effects of observational selection need to be called for, with 80 per cent of Q and M profiles assumed to be undetected because of intrinsic blending effects. It is concluded that the statistical properties of Q and M profiles are more consistent with the fan-shaped beams, than with the traditional nested-cone geometry.

A Comparison of Seyfert 1 and 2 Host Galaxies

NASA Astrophysics Data System (ADS)

De Robertis, M.; Virani, S.

2000-12-01

Wide-field, R-band CCD data of 15 Seyfert 1 and 15 Seyfert 2 galaxies taken from the CfA survey were analysed in order to compare the properties of their host galaxies. As well, B-band images for a subset of 12 Seyfert 1s and 7 Seyfert 2s were acquired and analysed in the same way. A robust technique for decomposing the three components---nucleus, bulge and disk---was developed in order determine the structural parameters for each galaxy. In effect, the nuclear contribution was removed empirically by using a spatially nearby, high signal-to-noise ratio point source as a template. Profile fits to the bulge+disk ignored data within three seeing disks of the nucleus. Of the many parameters that were compared between Seyfert 1s and 2s, only two distributions differed at greater than the 95% confidence level for the K-S test: the magnitude of the nuclear component, and the radial color gradient outside the nucleus. The former is expected. The latter could be consistent with some proposed evolutionary models. There is some suggestion that other parameters may differ, but at a lower confidence level.

Geomorphic effectiveness of long profile shape and role of inherent geological controls, Ganga River Basin, India

NASA Astrophysics Data System (ADS)

Sonam, Sonam; Jain, Vikrant

2017-04-01

River long profile is one of the fundamental geomorphic parameters which provides a platform to study interaction of geological and geomorphic processes at different time scales. Long profile shape is governed by geological processes at 10 ^ 5 - 10 ^ 6 years' time scale and it controls the modern day (10 ^ 0 - 10 ^ 1 years' time scale) fluvial processes by controlling the spatial variability of channel slope. Identification of an appropriate model for river long profile may provide a tool to analyse the quantitative relationship between basin geology, profile shape and its geomorphic effectiveness. A systematic analysis of long profiles has been carried for the Himalayan tributaries of the Ganga River basin. Long profile shape and stream power distribution pattern is derived using SRTM DEM data (90 m spatial resolution). Peak discharge data from 34 stations is used for hydrological analysis. Lithological variability and major thrusts are marked along the river long profile. The best fit of long profile is analysed for power, logarithmic and exponential function. Second order exponential function provides the best representation of long profiles. The second order exponential equation is Z = K1*exp(-β1*L) + K2*exp(-β2*L), where Z is elevation of channel long profile, L is the length, K and β are coefficients of the exponential function. K1 and K2 are the proportion of elevation change of the long profile represented by β1 (fast) and β2 (slow) decay coefficients of the river long profile. Different values of coefficients express the variability in long profile shapes and is related with the litho-tectonic variability of the study area. Channel slope of long profile is estimated taking the derivative of exponential function. Stream power distribution pattern along long profile is estimated by superimposing the discharge and long profile slope. Sensitivity analysis of stream power distribution with decay coefficients of the second order exponential equation is evaluated for a range of coefficient values. Our analysis suggests that the amplitude of stream power peak value is dependent on K1, the proportion of elevation change coming under the fast decay exponent and the location of stream power peak is dependent of the long profile decay coefficient (β1). Different long profile shapes owing to litho-tectonic variability across the Himalayas are responsible for spatial variability of stream power distribution pattern. Most of the stream power peaks lie in the Higher Himalaya. In general, eastern rivers have higher stream power in hinterland area and low stream power in the alluvial plains. This is responsible for, 1) higher erosion rate and sediment supply in hinterland of eastern rivers, 2) the incised and stable nature of channels in the western alluvial plains and 3) aggrading channels with dynamic nature in the eastern alluvial plains. Our study shows that the spatial variability of litho-units defines the coefficients of long profile function which in turn controls the position and magnitude of stream power maxima and hence the geomorphic variability in a fluvial system.

Experimental Design for Parameter Estimation of Gene Regulatory Networks

PubMed Central

Timmer, Jens

2012-01-01

Systems biology aims for building quantitative models to address unresolved issues in molecular biology. In order to describe the behavior of biological cells adequately, gene regulatory networks (GRNs) are intensively investigated. As the validity of models built for GRNs depends crucially on the kinetic rates, various methods have been developed to estimate these parameters from experimental data. For this purpose, it is favorable to choose the experimental conditions yielding maximal information. However, existing experimental design principles often rely on unfulfilled mathematical assumptions or become computationally demanding with growing model complexity. To solve this problem, we combined advanced methods for parameter and uncertainty estimation with experimental design considerations. As a showcase, we optimized three simulated GRNs in one of the challenges from the Dialogue for Reverse Engineering Assessment and Methods (DREAM). This article presents our approach, which was awarded the best performing procedure at the DREAM6 Estimation of Model Parameters challenge. For fast and reliable parameter estimation, local deterministic optimization of the likelihood was applied. We analyzed identifiability and precision of the estimates by calculating the profile likelihood. Furthermore, the profiles provided a way to uncover a selection of most informative experiments, from which the optimal one was chosen using additional criteria at every step of the design process. In conclusion, we provide a strategy for optimal experimental design and show its successful application on three highly nonlinear dynamic models. Although presented in the context of the GRNs to be inferred for the DREAM6 challenge, the approach is generic and applicable to most types of quantitative models in systems biology and other disciplines. PMID:22815723

Evaluation of dissolution profile similarity - Comparison between the f2, the multivariate statistical distance and the f2 bootstrapping methods.

PubMed

Paixão, Paulo; Gouveia, Luís F; Silva, Nuno; Morais, José A G

2017-03-01

A simulation study is presented, evaluating the performance of the f 2 , the model-independent multivariate statistical distance and the f 2 bootstrap methods in the ability to conclude similarity between two dissolution profiles. Different dissolution profiles, based on the Noyes-Whitney equation and ranging from theoretical f 2 values between 100 and 40, were simulated. Variability was introduced in the dissolution model parameters in an increasing order, ranging from a situation complying with the European guidelines requirements for the use of the f 2 metric to several situations where the f 2 metric could not be used anymore. Results have shown that the f 2 is an acceptable metric when used according to the regulatory requirements, but loses its applicability when variability increases. The multivariate statistical distance presented contradictory results in several of the simulation scenarios, which makes it an unreliable metric for dissolution profile comparisons. The bootstrap f 2 , although conservative in its conclusions is an alternative suitable method. Overall, as variability increases, all of the discussed methods reveal problems that can only be solved by increasing the number of dosage form units used in the comparison, which is usually not practical or feasible. Additionally, experimental corrective measures may be undertaken in order to reduce the overall variability, particularly when it is shown that it is mainly due to the dissolution assessment instead of being intrinsic to the dosage form. Copyright © 2016. Published by Elsevier B.V.

Wide spectral band beam analysis

NASA Astrophysics Data System (ADS)

Aharon, Oren

2015-03-01

The reality in laser beam profiling is that measurements are performed over a wide spectrum of wavelengths and power ranges. Many applications use multiple laser wavelengths with very different power levels, a fact which dictates a need for a better measuring tool. Rapid progress in the fiber laser area has increased the demand for lasers in the wavelength range of 900 - 1030 nm, while the telecommunication market has increased the demand for wavelength range of 1300nm - 1600 nm, on the other hand the silicone chip manufacturing and mass production requirements tend to lower the laser wavelength towards the 190nm region. In many cases there is a need to combine several lasers together in order to perform a specific task. A typical application is to combine one visible laser for pointing, with a different laser for material processing with a very different wavelength and power level. The visible laser enables accurate pointing before the second laser is operated. The beam profile of the intensity distribution is an important parameter that indicates how a laser beam will behave in an application. Currently a lab, where many different lasers are used, will find itself using various laser beam profilers from several vendors with different specifications and accuracies. It is the propose of this article to present a technological breakthrough in the area of detectors, electronics and optics allowing intricate measurements of lasers with different wavelength and with power levels that vary many orders of magnitude by a single beam profiler.

Breather solutions of a fourth-order nonlinear Schrödinger equation in the degenerate, soliton, and rogue wave limits

NASA Astrophysics Data System (ADS)

Chowdury, Amdad; Krolikowski, Wieslaw; Akhmediev, N.

2017-10-01

We present one- and two-breather solutions of the fourth-order nonlinear Schrödinger equation. With several parameters to play with, the solution may take a variety of forms. We consider most of these cases including the general form and limiting cases when the modulation frequencies are 0 or coincide. The zero-frequency limit produces a combination of breather-soliton structures on a constant background. The case of equal modulation frequencies produces a degenerate solution that requires a special technique for deriving. A zero-frequency limit of this degenerate solution produces a rational second-order rogue wave solution with a stretching factor involved. Taking, in addition, the zero limit of the stretching factor transforms the second-order rogue waves into a soliton. Adding a differential shift in the degenerate solution results in structural changes in the wave profile. Moreover, the zero-frequency limit of the degenerate solution with differential shift results in a rogue wave triplet. The zero limit of the stretching factor in this solution, in turn, transforms the triplet into a singlet plus a low-amplitude soliton on the background. A large value of the differential shift parameter converts the triplet into a pure singlet.

Breather solutions of a fourth-order nonlinear Schrödinger equation in the degenerate, soliton, and rogue wave limits.

PubMed

Chowdury, Amdad; Krolikowski, Wieslaw; Akhmediev, N

2017-10-01

We present one- and two-breather solutions of the fourth-order nonlinear Schrödinger equation. With several parameters to play with, the solution may take a variety of forms. We consider most of these cases including the general form and limiting cases when the modulation frequencies are 0 or coincide. The zero-frequency limit produces a combination of breather-soliton structures on a constant background. The case of equal modulation frequencies produces a degenerate solution that requires a special technique for deriving. A zero-frequency limit of this degenerate solution produces a rational second-order rogue wave solution with a stretching factor involved. Taking, in addition, the zero limit of the stretching factor transforms the second-order rogue waves into a soliton. Adding a differential shift in the degenerate solution results in structural changes in the wave profile. Moreover, the zero-frequency limit of the degenerate solution with differential shift results in a rogue wave triplet. The zero limit of the stretching factor in this solution, in turn, transforms the triplet into a singlet plus a low-amplitude soliton on the background. A large value of the differential shift parameter converts the triplet into a pure singlet.

Effects of Mean Flow Profiles on Instability of a Low-Density Gas Jet Injected into a High-Density Gas

NASA Technical Reports Server (NTRS)

Vedantam, Nanda Kishore

2003-01-01

The objective of this study was to investigate the effects of the mean flow profiles on the instability characteristics in the near-injector region of low-density gas jets injected into high-density ambient gas mediums. To achieve this, a linear temporal stability analysis and a spatio-temporal stability analysis of a low-density round gas jet injected vertically upwards into a high-density ambient gas were performed by assuming three different sets of mean velocity and density profiles. The flow was assumed to be isothermal and locally parallel. Viscous and diffusive effects were ignored. The mean flow parameters were represented as the sum of the mean value and a small normal-mode fluctuation. A second order differential equation governing the pressure disturbance amplitude was derived from the basic conservation equations. The first set of mean velocity and density profiles assumed were those used by Monkewitz and Sohn for investigating absolute instability in hot jets. The second set of velocity and density profiles assumed for this study were the ones used by Lawson. And the third set of mean profiles included a parabolic velocity profile and a hyperbolic tangent density profile. The effects of the inhomogeneous shear layer and the Froude number (signifying the effects of gravity) on the temporal and spatio-temporal results for each set of mean profiles were delineated. Additional information is included in the original extended abstract.

Inversion of scattered radiance horizon profiles for gaseous concentrations and aerosol parameters

NASA Technical Reports Server (NTRS)

Malchow, H. L.; Whitney, C. K.

1977-01-01

Techniques have been developed and used to invert limb scan measurements for vertical profiles of atmospheric state parameters. The parameters which can be found are concentrations of Rayleigh scatters, ozone, NO2, and aerosols, and aerosol physical properties including a Junge-size distribution parameter and real and imaginary parts of the index of refraction.

The shape parameter and its modification for defining coastal profiles

NASA Astrophysics Data System (ADS)

Türker, Umut; Kabdaşli, M. Sedat

2009-03-01

The shape parameter is important for the theoretical description of the sandy coastal profiles. This parameter has previously been defined as a function of the sediment-settling velocity. However, the settling velocity cannot be characterized over a wide range of sediment grains. This, in turn, limits the calculation of the shape parameter over a wide range. This paper provides a simpler and faster analytical equation to describe the shape parameter. The validity of the equation has been tested and compared with the previously estimated values given in both graphical and tabular forms. The results of this study indicate that the analytical solutions of the shape parameter improved the usability of profile better than graphical solutions, predicting better results both at the surf zone and offshore.

Geocoronal Balmer α line profile observations and forward-model analysis

NASA Astrophysics Data System (ADS)

Mierkiewicz, E. J.; Bishop, J.; Roesler, F. L.; Nossal, S. M.

2006-05-01

High spectral resolution geocoronal Balmer α line profile observations from Pine Bluff Observatory (PBO) are presented in the context of forward-model analysis. Because Balmer series column emissions depend significantly on multiple scattering, retrieval of hydrogen parameters of general aeronomic interest from these observations (e.g., the hydrogen column abundance) currently requires a forward modeling approach. This capability is provided by the resonance radiative transfer code LYAO_RT. We have recently developed a parametric data-model comparison search procedure employing an extensive grid of radiative transport model input parameters (defining a 6-dimensional parameter space) to map-out bounds for feasible forward model retrieved atomic hydrogen density distributions. We applied this technique to same-night (March, 2000) ground-based Balmer α data from PBO and geocoronal Lyman β measurements from the Espectrógrafo Ultravioleta extremo para la Radiación Difusa (EURD) instrument on the Spanish satellite MINISAT-1 (provided by J.F. Gómez and C. Morales of the Laboratorio de Astrofisica Espacial y Física Fundamental, INTA, Madrid, Spain) in order to investigate the modeling constraints imposed by two sets of independent geocoronal intensity measurements, both of which rely on astronomical calibration methods. In this poster we explore extending this analysis to the line profile information also contained in the March 2000 PBO Balmer α data set. In general, a decrease in the Doppler width of the Balmer α emission with shadow altitude is a persistent feature in every night of PBO observations in which a wide range of shadow altitudes are observed. Preliminary applications of the LYAO_RT code, which includes the ability to output Doppler line profiles for both the singly and multiply scattered contributions to the Balmer α emission line, displays good qualitative agreement with regard to geocoronal Doppler width trends observed from PBO. Model-data Balmer α Doppler width comparisons, using the best-fit model parameters obtained during the March 2000 PBO/EURD forward-model study, will be presented and discussed, including the feasibility of using Balmer α observed Doppler widths as an additional model constraint in our forward-model search procedure.

Fundamental Parameters Line Profile Fitting in Laboratory Diffractometers

PubMed Central

Cheary, R. W.; Coelho, A. A.; Cline, J. P.

2004-01-01

The fundamental parameters approach to line profile fitting uses physically based models to generate the line profile shapes. Fundamental parameters profile fitting (FPPF) has been used to synthesize and fit data from both parallel beam and divergent beam diffractometers. The refined parameters are determined by the diffractometer configuration. In a divergent beam diffractometer these include the angular aperture of the divergence slit, the width and axial length of the receiving slit, the angular apertures of the axial Soller slits, the length and projected width of the x-ray source, the absorption coefficient and axial length of the sample. In a parallel beam system the principal parameters are the angular aperture of the equatorial analyser/Soller slits and the angular apertures of the axial Soller slits. The presence of a monochromator in the beam path is normally accommodated by modifying the wavelength spectrum and/or by changing one or more of the axial divergence parameters. Flat analyzer crystals have been incorporated into FPPF as a Lorentzian shaped angular acceptance function. One of the intrinsic benefits of the fundamental parameters approach is its adaptability any laboratory diffractometer. Good fits can normally be obtained over the whole 20 range without refinement using the known properties of the diffractometer, such as the slit sizes and diffractometer radius, and emission profile. PMID:27366594

Simulation on Natural Convection of a Nanofluid along an Isothermal Inclined Plate

NASA Astrophysics Data System (ADS)

Mitra, Asish

2017-08-01

A numerical algorithm is presented for studying laminar natural convection flow of a nanofluid along an isothermal inclined plate. By means of similarity transformation, the original nonlinear partial differential equations of flow are transformed to a set of nonlinear ordinary differential equations. Subsequently they are reduced to a first order system and integrated using Newton Raphson and adaptive Runge-Kutta methods. The computer codes are developed for this numerical analysis in Matlab environment. Dimensionless velocity, temperature profiles and nanoparticle concentration for various angles of inclination are illustrated graphically. The effects of Prandtl number, Brownian motion parameter and thermophoresis parameter on Nusselt number are also discussed. The results of the present simulation are then compared with previous one available in literature with good agreement.

Polarizable atomic multipole-based force field for DOPC and POPE membrane lipids

NASA Astrophysics Data System (ADS)

Chu, Huiying; Peng, Xiangda; Li, Yan; Zhang, Yuebin; Min, Hanyi; Li, Guohui

2018-04-01

A polarizable atomic multipole-based force field for the membrane bilayer models 1,2-dioleoyl-phosphocholine (DOPC) and 1-palmitoyl-2-oleoyl-phosphatidylethanolamine (POPE) has been developed. The force field adopts the same framework as the Atomic Multipole Optimized Energetics for Biomolecular Applications (AMOEBA) model, in which the charge distribution of each atom is represented by the permanent atomic monopole, dipole and quadrupole moments. Many-body polarization including the inter- and intra-molecular polarization is modelled in a consistent manner with distributed atomic polarizabilities. The van der Waals parameters were first transferred from existing AMOEBA parameters for small organic molecules and then optimised by fitting to ab initio intermolecular interaction energies between models and a water molecule. Molecular dynamics simulations of the two aqueous DOPC and POPE membrane bilayer systems, consisting of 72 model molecules, were then carried out to validate the force field parameters. Membrane width, area per lipid, volume per lipid, deuterium order parameters, electron density profile, etc. were consistent with experimental values.

Kinetic study of olive oil degradation monitored by fourier transform infrared spectrometry. Application to oil characterization.

PubMed

Román Falcó, Iván P; Grané Teruel, Nuria; Prats Moya, Soledad; Martín Carratalá, M Luisa

2012-11-28

A new approach for the determination of kinetic parameters of the cis/trans isomerization during the oxidation process of 24 virgin olive oils belonging to 8 different varieties is presented. The accelerated process of degradation at 100 °C was monitored by recording the Fourier transform infrared spectra. The parameters obtained confirm pseudo-first-order kinetics for the degradation of cis and the appearance of trans double bonds. The kinetic approach affords the induction time and the rate coefficient; these parameters are related to the fatty acid profile of the fresh olive oils. The data obtained were used to compare the oil stability of the samples with the help of multivariate statistical techniques. Fatty acid allowed a classification of the samples in five groups, one of them constituted by the cultivars with higher stability. Meanwhile, the kinetic parameters showed greater ability for the characterization of olive oils, allowing the classification in seven groups.

Behavior of some psychological parameters in a population of a Hg extraction plant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camerino, D.; Cassitto, M.G.; Desideri, E.

1981-11-01

52 workers of a plant transforming Hg mineral were subjected to psychological investigation in order to detect behavioral alterations which might be related to Hg exposure. A group of 29 subjects living in the same area was used as the control. The test battery included reaction times, mental efficiency measures, and personality indexes for a total of 33 variables. Results were analyzed through statistical elaboration using parametric tests. Efficiency and memory measures could discriminate exposed individuals from controls; for the personality profiles, an interpretation explaining the differences observed is proposed in terms of a dynamic profile having different characteristics inmore » the different groups studied. Reference to existing literature is made to verify any possible correlation with other authors' findings.« less

Catenary-induced geometric nonlinearity effects on cable linear vibrations

NASA Astrophysics Data System (ADS)

Mansour, Achref; Mekki, Othman Ben; Montassar, Sami; Rega, Giuseppe

2018-01-01

This paper investigates the free undamped vibrations of cables of arbitrary sag and inclination according to the catenary theory. The proposed approach accounts for the catenary effect on the static profile around which the cable motion is defined. Considering first order geometric nonlinearities, exact expression of the curvature is obtained along with the ensuing correction of the well known Irvine parameter. Taking into account the new characterization, different regions of shallow and non-shallow profiles are identified for various inclinations. In view of such classification, the analysis carried out on cable linear modal properties shows the emergence of new dynamic features such as additional hybrid modes and internal resonances. Analytical and numerical results reduce to those obtained by classic formulations in the cases of both horizontal and inclined shallow/non-shallow cables.

Influence of low-temperature resistivity on fast electron transport in solids: scaling to fast ignition electron beam parameters

NASA Astrophysics Data System (ADS)

McKenna, P.; MacLellan, D. A.; Butler, N. M. H.; Dance, R. J.; Gray, R. J.; Robinson, A. P. L.; Neely, D.; Desjarlais, M. P.

2015-06-01

The role of low-temperature electrical resistivity in defining the transport properties of mega-Ampere currents of fast (MeV) electrons in solids is investigated using 3D hybrid particle-in-cell (PIC) simulations. By considering resistivity profiles intermediate to the ordered (lattice) and disordered forms of two example materials, lithium and silicon, it is shown that both the magnitude of the resistivity and the shape of the resistivity-temperature profile at low temperatures strongly affect the self-generated resistive magnetic fields and the onset of resistive instabilities, and thus the overall fast electron beam transport pattern. The scaling of these effects to the giga-Ampere electron currents required for the fast ignition scheme for inertial fusion is also explored.

Transparency of the 2 μm (5000 cm-1) methane window in Titan's atmosphere and impact on retrieved surface reflectivity

NASA Astrophysics Data System (ADS)

Rannou, Pascal; Seignovert, Benoit; Le Mouélic, Stéphane; Sotin, Christophe

2016-10-01

The study of Titan properties with remote sensing relies on a good knowledge of the atmosphere properties. The in-situ observations made by Huygens combined with recent advances in the definition of methane properties enable to model and interpret observations with a very good accuracy. Thanks to these progresses, we can analyze in this work the observations made at the limb of Titan in order to retrieve information on the haze properties as its vertical profiles and its spectral behaviour along the VIMS/Cassini range (from 0.88 to 5.1 μm). However, for applications to real atmospheres, one need to account for the widening of the spectroscopic lines (e.g., Voigt profile) and apply an empirical cut-off of the far wings. In general, this is a multiplying function of the wavenumber, f(ν), applied to the Voigt profile that allows a faster decay of the wing profile beyond a given distance from the center of the line ν0 : f(ν)=1 if |ν- ν0| ≤ Δν, and f(ν)=exp(-|ν- ν0|/ σ) if |ν- ν0| > Δν. Although the 2-μm window is apparently straitforward to model, it appears that the standard cut-off parameters (that is Δν ~ 26 cm-1 and σ ~ 120 cm-1) which is used for other windows in Titan's atmosphere is not adequat for this window. Other sets of parameter must be used to reproduce Titan spectrum at 2 μm. However, there is no convergence of the results between these works and a large variety of cut-off parameters are used. Alternatively, it was found that some gas absorptions (ethane and another unknown gas) leave a signature around 2-μm and also affect the transparency in this window. In our study we make an exhaustive investigation on the cut-off parameters to determine which are the best couples of parameters to fit the 2-μm window. We also evaluated how gaseous absorptions can allow to reach a satisfactory agreement and, especially, if it allows to match observations with the standard cut-off. Finally, we investigate the impact of the different solutions (different cut-off, with or without supplementary absorptions) on the retrieved surface albedo.

Smoothing of geoelectrical resistivity profiles in order to build a 3D model: A case study from an outcropping limestone block

NASA Astrophysics Data System (ADS)

Tóth, Krisztina; Kovács, Gábor

2014-05-01

Geoelectrical imaging is one of the most common survey methods in the field of shallow geophysics. In order to get information from the subsurface electric current is induced into the ground. In our summer camp organized by the Department of Geophysics and Space Sciences, Eötvös Loránd University we have carried out resistivity surveys to get more accurate information about the lithology of the Dorog basin located in the Transdanubian range, Middle Hungary. This study focused on the outcropping limestone block located next to the village Leányvár in the Dorog basin. The main aim of the research is the impoundment of the subsurface continuation of the limestone outcrop. Cable problems occurred during field survey therefore the dataset obtained by the measurement have become very noisy thus we had to gain smoothed data with the appropriate editing steps. The goal was to produce an optimized model to demonstrate the reality beneath the subsurface. In order to achieve better results from the noisy dataset we changed some parameters based on the description of the program. Whereas cable problems occurred we exterminated the bad datum points visually and statistically as well. Because of the noisiness we increased the value of the so called damping factor which is a variable parameter in the equation used by the inversion routine responsible for smoothing the data. The limitation of the range of model resistivity values based on our knowledge about geological environment was also necessary in order to avoid physically unrealistic results. The purpose of the modification was to obtain smoothed and more interpretable geoelectric profiles. The geological background combined with the explanation of the profiles gave us the approximate location of the block. In the final step of the research we created a 3D model with proper location and smoothed resistivity data included. This study was supported by the Hungarian Scientific Research Fund (OTKA NK83400) and was realized in the frames of TÁMOP 4.2.4.A/2-11-1-2012-0001 high priority "National Excellence Program - Elaborating and Operating an Inland Student and Researcher Personal Support System convergence program" project's scholarship support.

A statistical evaluation and comparison of VISSR Atmospheric Sounder (VAS) data

NASA Technical Reports Server (NTRS)

Jedlovec, G. J.

1984-01-01

In order to account for the temporal and spatial discrepancies between the VAS and rawinsonde soundings, the rawinsonde data were adjusted to a common hour of release where the new observation time corresponded to the satellite scan time. Both the satellite and rawinsonde observations of the basic atmospheric parameters (T Td, and Z) were objectively analyzed to a uniform grid maintaining the same mesoscale structure in each data set. The performance of each retrieval algorithm in producing accurate and representative soundings was evaluated using statistical parameters such as the mean, standard deviation, and root mean square of the difference fields for each parameter and grid level. Horizontal structure was also qualitatively evaluated by examining atmospheric features on constant pressure surfaces. An analysis of the vertical structure of the atmosphere were also performed by looking at colocated and grid mean vertical profiles of both the satellite and rawinsonde data sets. Highlights of these results are presented.

Investigation of antenna pattern constraints for passive geosynchronous microwave imaging radiometers

NASA Technical Reports Server (NTRS)

Gasiewski, A. J.; Skofronick, G. M.

1992-01-01

Progress by investigators at Georgia Tech in defining the requirements for large space antennas for passive microwave Earth imaging systems is reviewed. In order to determine antenna constraints (e.g., the aperture size, illumination taper, and gain uncertainty limits) necessary for the retrieval of geophysical parameters (e.g., rain rate) with adequate spatial resolution and accuracy, a numerical simulation of the passive microwave observation and retrieval process is being developed. Due to the small spatial scale of precipitation and the nonlinear relationships between precipitation parameters (e.g., rain rate, water density profile) and observed brightness temperatures, the retrieval of precipitation parameters are of primary interest in the simulation studies. Major components of the simulation are described as well as progress and plans for completion. The overall goal of providing quantitative assessments of the accuracy of candidate geosynchronous and low-Earth orbiting imaging systems will continue under a separate grant.

Inversion method applied to the rotation curves of galaxies

NASA Astrophysics Data System (ADS)

Márquez-Caicedo, L. A.; Lora-Clavijo, F. D.; Sanabria-Gómez, J. D.

2017-07-01

We used simulated annealing, Montecarlo and genetic algorithm methods for matching both numerical data of density and velocity profiles in some low surface brigthness galaxies with theoretical models of Boehmer-Harko, Navarro-Frenk-White and Pseudo Isothermal Profiles for galaxies with dark matter halos. We found that Navarro-Frenk-White model does not fit at all in contrast with the other two models which fit very well. Inversion methods have been widely used in various branches of science including astrophysics (Charbonneau 1995, ApJS, 101, 309). In this work we have used three different parametric inversion methods (MonteCarlo, Genetic Algorithm and Simmulated Annealing) in order to determine the best fit of the observed data of the density and velocity profiles of a set of low surface brigthness galaxies (De Block et al. 2001, ApJ, 122, 2396) with three models of galaxies containing dark mattter. The parameters adjusted by the inversion methods were the central density and a characteristic distance in the Boehmer-Harko BH (Boehmer & Harko 2007, JCAP, 6, 25), Navarro-Frenk-White NFW (Navarro et al. 2007, ApJ, 490, 493) and Pseudo Isothermal Profile PI (Robles & Matos 2012, MNRAS, 422, 282). The results obtained showed that the BH and PI Profile dark matter galaxies fit very well for both the density and the velocity profiles, in contrast the NFW model did not make good adjustments to the profiles in any analized galaxy.

Development of Fractal Dimension and Characteristic Roughness Models for Turned Surface of Carbon Steels

NASA Astrophysics Data System (ADS)

Zuo, Xue; Zhu, Hua; Zhou, Yuankai; Ding, Cong; Sun, Guodong

2016-08-01

Relationships between material hardness, turning parameters (spindle speed and feed rate) and surface parameters (surface roughness Ra, fractal dimension D and characteristic roughness τ∗) are studied and modeled using response surface methodology (RSM). The experiments are carried out on a CNC lathe for six carbon steel material AISI 1010, AISI 1020, AISI 1030, AISI 1045, AISI 1050 and AISI 1060. The profile of turned surface and the surface roughness value are measured by a JB-5C profilometer. Based on the profile data, D and τ∗ are computed through the root-mean-square method. The analysis of variance (ANOVA) reveals that spindle speed is the most significant factors affecting Ra, while material hardness is the most dominant parameter affecting τ∗. Material hardness and spindle speed have the same influence on D. Feed rate has less effect on three surface parameters than spindle speed and material hardness. The second-order models of RSM are established for estimating Ra, D and τ∗. The validity of the developed models is approximately 80%. The response surfaces show that a surface with small Ra and large D and τ∗ can be obtained by selecting a high speed and a large hardness material. According to the established models, Ra, D and τ∗ of six carbon steels surfaces can be predicted under cutting conditions studied in this paper. The results have an instructive meaning to estimate the surface quality before turning.

Nonlocal homogenization theory in metamaterials: Effective electromagnetic spatial dispersion and artificial chirality

NASA Astrophysics Data System (ADS)

Ciattoni, Alessandro; Rizza, Carlo

2015-05-01

We develop, from first principles, a general and compact formalism for predicting the electromagnetic response of a metamaterial with nonmagnetic inclusions in the long-wavelength limit, including spatial dispersion up to the second order. Specifically, by resorting to a suitable multiscale technique, we show that the effective medium permittivity tensor and the first- and second-order tensors describing spatial dispersion can be evaluated by averaging suitable spatially rapidly varying fields, each satisfying electrostatic-like equations within the metamaterial unit cell. For metamaterials with negligible second-order spatial dispersion, we exploit the equivalence of first-order spatial dispersion and reciprocal bianisotropic electromagnetic response to deduce a simple expression for the metamaterial chirality tensor. Such an expression allows us to systematically analyze the effect of the composite spatial symmetry properties on electromagnetic chirality. We find that even if a metamaterial is geometrically achiral, i.e., it is indistinguishable from its mirror image, it shows pseudo-chiral-omega electromagnetic chirality if the rotation needed to restore the dielectric profile after the reflection is either a 0∘ or 90∘ rotation around an axis orthogonal to the reflection plane. These two symmetric situations encompass two-dimensional and one-dimensional metamaterials with chiral response. As an example admitting full analytical description, we discuss one-dimensional metamaterials whose single chirality parameter is shown to be directly related to the metamaterial dielectric profile by quadratures.

Computer Program for Calculation of a Gas Temperature Profile by Infrared Emission: Absorption Spectroscopy

NASA Technical Reports Server (NTRS)

Buchele, D. R.

1977-01-01

A computer program to calculate the temperature profile of a flame or hot gas was presented in detail. Emphasis was on profiles found in jet engine or rocket engine exhaust streams containing H2O or CO2 radiating gases. The temperature profile was assumed axisymmetric with an assumed functional form controlled by two variable parameters. The parameters were calculated using measurements of gas radiation at two wavelengths in the infrared. The program also gave some information on the pressure profile. A method of selection of wavelengths was given that is likely to lead to an accurate determination of the parameters. The program is written in FORTRAN IV language and runs in less than 60 seconds on a Univac 1100 computer.

Quantification of key long-term risks at CO₂ sequestration sites: Latest results from US DOE's National Risk Assessment Partnership (NRAP) Project

DOE PAGES

Pawar, Rajesh; Bromhal, Grant; Carroll, Susan; ...

2014-12-31

Risk assessment for geologic CO₂ storage including quantification of risks is an area of active investigation. The National Risk Assessment Partnership (NRAP) is a US-Department of Energy (US-DOE) effort focused on developing a defensible, science-based methodology and platform for quantifying risk profiles at geologic CO₂ sequestration sites. NRAP has been developing a methodology that centers round development of an integrated assessment model (IAM) using system modeling approach to quantify risks and risk profiles. The IAM has been used to calculate risk profiles with a few key potential impacts due to potential CO₂ and brine leakage. The simulation results are alsomore » used to determine long-term storage security relationships and compare the long-term storage effectiveness to IPCC storage permanence goal. Additionally, we also demonstrate application of IAM for uncertainty quantification in order to determine parameters to which the uncertainty in model results is most sensitive.« less

Residual vibration control based on a global search method in a high-speed white light scanning interferometer.

PubMed

Song, Zhenyuan; Guo, Tong; Fu, Xing; Hu, Xiaotang

2018-05-01

To achieve high-speed measurements using white light scanning interferometers, the scanning devices used need to have high feedback gain in closed-loop operations. However, flexure hinges induce a residual vibration that can cause a misidentification of the fringe order. The reduction of this residual vibration is crucial because the highly nonlinear distortions in interferograms lead to clearly incorrect measured profiles. Input shaping can be used to control the amplitude of the residual vibration. The conventional method uses continuous wavelet transform (CWT) to estimate parameters of the scanning device. Our proposed method extracts equivalent modal parameters using a global search algorithm. Due to its simplicity, ease of implementation, and response speed, this global search method outperforms CWT. The delay time is shortened by searching, because fewer modes are needed for the shaper. The effectiveness of the method has been confirmed by the agreement between simulated shaped responses and experimental displacement information from the capacitive sensor inside the scanning device, and the intensity profiles of the interferometer have been greatly improved. An experiment measuring the surface of a silicon wafer is also presented. The method is shown to be effective at improving the intensity profiles and recovering accurate surface topography. Finally, frequency localizations are found to be almost stable with different proportional gains, but their energy distributions change.

Current drive for stability of thermonuclear plasma reactor

NASA Astrophysics Data System (ADS)

Amicucci, L.; Cardinali, A.; Castaldo, C.; Cesario, R.; Galli, A.; Panaccione, L.; Paoletti, F.; Schettini, G.; Spigler, R.; Tuccillo, A.

2016-01-01

To produce in a thermonuclear fusion reactor based on the tokamak concept a sufficiently high fusion gain together stability necessary for operations represent a major challenge, which depends on the capability of driving non-inductive current in the hydrogen plasma. This request should be satisfied by radio-frequency (RF) power suitable for producing the lower hybrid current drive (LHCD) effect, recently demonstrated successfully occurring also at reactor-graded high plasma densities. An LHCD-based tool should be in principle capable of tailoring the plasma current density in the outer radial half of plasma column, where other methods are much less effective, in order to ensure operations in the presence of unpredictably changes of the plasma pressure profiles. In the presence of too high electron temperatures even at the periphery of the plasma column, as envisaged in DEMO reactor, the penetration of the coupled RF power into the plasma core was believed for long time problematic and, only recently, numerical modelling results based on standard plasma wave theory, have shown that this problem should be solved by using suitable parameter of the antenna power spectrum. We show here further information on the new understanding of the RF power deposition profile dependence on antenna parameters, which supports the conclusion that current can be actively driven over a broad layer of the outer radial half of plasma column, thus enabling current profile control necessary for the stability of a reactor.

Flow characteristics control turnover of polar trace organic compounds in the hyporheic zone of an urban lowland river

NASA Astrophysics Data System (ADS)

Schaper, Jonas L.; Seher, Wiebke; Jaeger, Anna; Galloway, Jason; Nuetzmann, Gunnar; Putschew, Anke; Lewandowski, Joerg

2017-04-01

Hyporheic zones are hypothesized to be important sinks for polar trace organic compounds (TrOCs) in lotic systems, mitigating potential adverse effects of TrOCs on ecosystem functioning and drinking water production. Predicting the fate of TrOCs in the hyporheic zone, however, is difficult as the attenuation rate itself as well as the biogeochemical factors and hydrological conditions controlling attenuation rates are unknown. We used time series of temperature depth profiles as well as heat pulse sensing with a 1D advection dispersion transport model to calculate first order attenuation rates of several TrOCs from equilibrium depth profiles in an urban lowland river in Berlin, Germany. Ring enclosures were used to prohibit horizontal flow and to create distinct biogeochemical conditions within the hyporheic zone. Flow characteristics as well as biogeochemical conditions showed pronounced differences between depth profiles inside and outside of enclosures. TrOCs attenuation rates varied considerably among compounds reflecting their general susceptibility to biodegradation and sorption. While for some compounds such as benzotriazole and sulfamethoxazole redox conditions had an influence on attenuation rates, the fate of other compounds was not affected by biogeochemical parameters. Under loosing conditions, hyporheic zones of urban lowland rivers can thus be regarded as sinks for TrOCs. Their effectiveness is dependent on both, hyporheic exchange characteristics as well as biogeochemical parameters.

Efficient calculation of general Voigt profiles

NASA Astrophysics Data System (ADS)

Cope, D.; Khoury, R.; Lovett, R. J.

1988-02-01

An accurate and efficient program is presented for the computation of OIL profiles, generalizations of the Voigt profile resulting from the one-interacting-level model of Ward et al. (1974). These profiles have speed dependent shift and width functions and have asymmetric shapes. The program contains an adjustable error control parameter and includes the Voigt profile as a special case, although the general nature of this program renders it slower than a specialized Voigt profile method. Results on accuracy and computation time are presented for a broad set of test parameters, and a comparison is made with previous work on the asymptotic behavior of general Voigt profiles.

Virtual Ionosonde Construction by using ITS and IRI-2012 models

NASA Astrophysics Data System (ADS)

Kabasakal, Mehmet; Toker, Cenk

2016-07-01

Ionosonde is a kind of radar which is used to examine several properties of the ionosphere, including the electron density and drift velocity. Ionosonde is an expensive device and its installation requires special expertise and a proper area clear of sources of radio interference. In order to overcome the difficulties of installing an ionosonde hardware, the target of this study is to construct a virtual ionosonde based on communication channel models where the model parameters are determined by ray tracing obtained by the PHaRLAP software and the International Reference Ionosphere (IRI-2012) model. Although narrowband high frequency (HF) communication models have been widely used to represent the behaviour of the radio channel, they are applicable to a limited set of actual propagation conditions and wideband models are needed to better understand the HF channel. In 1997, the Institute for Telecommunication Science (ITS) developed a wideband HF ionospheric model, the so-called ITS model, however, it has some restrictions in real life applications. The ITS model parameters are grouped into two parts; the deterministic and the stochastic parameters. The deterministic parameters are the delay time (tau _{c}) of each reflection path based on the penetration frequency (f _{p}), the height (h _{0}) of the maximum electron density and the half thickness (sigma) of the reflective layer. The stochastic parameters, delay spread (sigma _{tau}), delay rise time (sigma _{c}), Doppler spread (sigma _{D}), Doppler shift (f _{s}), are to calculate the impulse response of the channel. These parameters are generally difficult to obtain and are based on the measured data which may not be available in all cases. In order to obtain these parameters, we propose to integrate the PHaRLAP ray tracing toolbox and the IRI-2012 model. When Total Electron Content (TEC) estimates obtained from GNSS measurements are input to IRI-2012, the model generates electron density profiles close to the actual profiles, which are used for ray tracing between the user defined geographical coordinates. Then, ITS model parameters are obtained from both ray tracing and also the IRI-2012 model. Finally, an ionosonde signal waveform is transmitted through the channel obtained from the ITS model to generate the ionogram. As an application, oblique sounding between two points is simulated with ITS channel model. M-sequence, Barker sequence and complementary sequences are used as sounding waveforms. The effects of channel on the oblique ionogram and sounding waveform characteristics are also investigated.

A Microwave Radiometric Method to Obtain the Average Path Profile of Atmospheric Temperature and Humidity Structure Parameters and Its Application to Optical Propagation System Assessment

NASA Technical Reports Server (NTRS)

Manning, Robert M.; Vyhnalek, Brian E.

2015-01-01

The values of the key atmospheric propagation parameters Ct2, Cq2, and Ctq are highly dependent upon the vertical height within the atmosphere thus making it necessary to specify profiles of these values along the atmospheric propagation path. The remote sensing method suggested and described in this work makes use of a rapidly integrating microwave profiling radiometer to capture profiles of temperature and humidity through the atmosphere. The integration times of currently available profiling radiometers are such that they are approaching the temporal intervals over which one can possibly make meaningful assessments of these key atmospheric parameters. Since these parameters are fundamental to all propagation conditions, they can be used to obtain Cn2 profiles for any frequency, including those for an optical propagation path. In this case the important performance parameters of the prevailing isoplanatic angle and Greenwood frequency can be obtained. The integration times are such that Kolmogorov turbulence theory and the Taylor frozen-flow hypothesis must be transcended. Appropriate modifications to these classical approaches are derived from first principles and an expression for the structure functions are obtained. The theory is then applied to an experimental scenario and shows very good results.

An analytical model for the distribution of CO2 sources and sinks, fluxes, and mean concentration within the roughness sub-layer

NASA Astrophysics Data System (ADS)

Siqueira, M. B.; Katul, G. G.

2009-12-01

A one-dimensional analytical model that predicts foliage CO2 uptake rates, turbulent fluxes, and mean concentration throughout the roughness sub-layer (RSL), a layer that extends from the ground surface up to 5 times the canopy height (h), is proposed. The model combines the mean continuity equation for CO2 with first-order closure principles for turbulent fluxes and simplified physiological and radiative transfer schemes for foliage uptake. This combination results in a second-order ordinary differential equation in which it is imposed soil respiration (RE) as lower and CO2 concentration well above the RSL as upper boundary conditions. An inverse version of the model was tested against data sets from two contrasting ecosystems: a tropical forest (TF, h=40 m) and a managed irrigated rice canopy (RC, h=0.7 m) - with good agreement noted between modeled and measured mean CO2 concentration profiles within the entire RSL (see figure). Sensitivity analysis on the model parameters revealed a plausible scaling regime between them and a dimensionless parameter defined by the ratio between external (RE) and internal (stomatal conductance) characteristics controlling the CO2 exchange process. The model can be used to infer the thickness of the RSL for CO2 exchange, the inequality in zero-plane displacement between CO2 and momentum, and its consequences on modeled CO2 fluxes. A simplified version of the solution is well suited for being incorporated into large-scale climate models. Furthermore, the model framework here can be used to a priori estimate relative contributions from the soil surface and the atmosphere to canopy-air CO2 concentration thereby making it synergetic to stable isotopes studies. Panels a) and c): Profiles of normalized measured leaf area density distribution (a) for TF and RC, respectively. Continuous lines are the constant a used in the model and dashed lines represent data-derived profiles. Panels b) and d) are modeled and ensemble-averaged measured CO2 profiles reference to the uppermost measured point for TF and RC, respectively.

Interpersonal Development, Stability, and Change in Early Adulthood

PubMed Central

Wright, Aidan G. C.; Pincus, Aaron L.; Lenzenweger, Mark F.

2011-01-01

Objective This goal of this research was to explore the development of the interpersonal system mapped by the interpersonal circumplex in early adulthood (Ages 18-22). Method This study uses the Longitudinal Study of Personality Disorders sample (N = 250; 53% Female). Participants completed the Revised Interpersonal Adjective Scales (Wiggins, Trapnell, & Phillips, 1988) in their freshman, sophomore, and senior years of college. Estimates of structural, rank-order, mean, individual, and ipsative stability were calculated for the broad interpersonal dimensions of Dominance and Affiliation, and also the lower-order octant scales. Additionally, the interpersonal profile parameters of differentiation and prototypicality were calculated at each wave and explored longitudinally, and also used as predictors of interpersonal stability. Results We found excellent structural and high rank-order and ipsative stability in the interpersonal scales over this time period. Mean increases on the Affiliation axis, but not on the Dominance axis, were found to mask differential rates of change among the octant scales, along with significant individual variation in the rates of change. Interpersonal differentiation and prototypicality were related to higher stability in overall interpersonal style. Conclusions Results point to evidence of both stability and nuanced change, illuminating some of the features of the structural variables that can be derived from interpersonal circumplex profiles. PMID:22224462

Arrays of quasi-hexagonally ordered silica nanopillars with independently controlled areal density, diameter and height gradients

NASA Astrophysics Data System (ADS)

Özdemir, Burcin; Huang, Wenting; Plettl, Alfred; Ziemann, Paul

2015-03-01

A consecutive fabrication approach of independently tailored gradients of the topographical parameters distance, diameter and height in arrays of well-ordered nanopillars on smooth SiO2-Si-wafers is presented. For this purpose, previously reported preparation techniques are further developed and combined. First, self-assembly of Au-salt loaded micelles by dip-coating with computer-controlled pulling-out velocities and subsequent hydrogen plasma treatment produce quasi-hexagonally ordered, 2-dimensional arrays of Au nanoparticles (NPs) with unidirectional variations of the interparticle distances along the pulling direction between 50-120 nm. Second, the distance (or areal density) gradient profile received in this way is superimposed with a diameter-controlled gradient profile of the NPs applying a selective photochemical growth technique. For demonstration, a 1D shutter is used for locally defined UV exposure times to prepare Au NP size gradients varying between 12 and 30 nm. Third, these double-gradient NP arrangements serve as etching masks in a following reactive ion etching step delivering arrays of nanopillars. For height gradient generation, the etching time is locally controlled by applying a shutter made from Si wafer piece. Due to the high flexibility of the etching process, the preparation route works on various materials such as cover slips, silicon, silicon oxide, silicon nitride and silicon carbide.

Parameters controlling mechanical stratification of gas-bearing shale complexes: integration of wellbore logging and core profiling (Peri-Baltic Basin, Poland).

NASA Astrophysics Data System (ADS)

Pachytel, Radomir; Jarosiński, Marek; Bobek, Kinga; Roszkowska-Remin, Joanna; Roman, Michał

2016-04-01

In our study of mechanical properties of gas-bearing shale complexes from exploration wells in Pomerania, we take advantage from having access to continuous, several hundred meters long core profiles which are supplemented with complete sets of geophysical logging from the same shale intervals. We are focused on different approaches to discriminate the Consistent Mechanical Units (CMUs). Such units are essential for mechanical modeling of stress and strain in shales and their scale is highly dependent on the purpose of analyses. We have done a precise lithological and structural core profiling, which results in distinguishing Consistent Lithological Units (CLUs) at a centimeter scale. The geophysical logs, essential for mechanical studies, exhibit resolution from tens of centimeters to a meter. The meter resolution we have found appropriate for consideration of mechanics of hydraulic fracture propagation and therefore we have used it in CMUs analysis. The first challenge we have faced is to switch between scales of analyses without significant losses of information coming from the lower level of observation. The next challenge, is to find the mechanical parameter which is able to discriminate CMUs most efficiently. Brittleness Indexes (BIs) are commonly used parameters in order to characterize mechanical shale units, but at the same time these indexes are arbitrary defined to match individual requirements of the users. In our study, we have determined the BIs in several ways, based either on mineral composition or on elastic modules, both supplemented with pore volume. The gamma ray (GR), Young modulus (YM), Poisson Ratio (ν) interpretation from acoustic logging, bulk density (RHOB), porosity interpretation (ø) and mineralogical profile (ULTRA, GEM) from spectral logging were computed. Detailed comparison of lithological profile and discriminated CLUs with above logs led us to conclusions about geophysical representation of dolomite and silica lithified shale, organic matter enrichment tuffite layers or disturbances in lamination, which are important for mechanical differentiation of shale complexes. Finally, we have checked which of the calculated BIs matches best the lithological differentiation and the natural fracture density profile that allowed us for selection of the BI which, in our opinion, represents the potential for hydraulic fracture propagation. Our study in the frame of ShaleMech Project (Blue Gas Program) is in progress and the results are preliminary.

Partial compensation interferometry for measurement of surface parameter error of high-order aspheric surfaces

NASA Astrophysics Data System (ADS)

Hao, Qun; Li, Tengfei; Hu, Yao

2018-01-01

Surface parameters are the properties to describe the shape characters of aspheric surface, which mainly include vertex radius of curvature (VROC) and conic constant (CC). The VROC affects the basic properties, such as focal length of an aspheric surface, while the CC is the basis of classification for aspheric surface. The deviations of the two parameters are defined as surface parameter error (SPE). Precisely measuring SPE is critical for manufacturing and aligning aspheric surface. Generally, SPE of aspheric surface is measured directly by curvature fitting on the absolute profile measurement data from contact or non-contact testing. And most interferometry-based methods adopt null compensators or null computer-generated holograms to measure SPE. To our knowledge, there is no effective way to measure SPE of highorder aspheric surface with non-null interferometry. In this paper, based on the theory of slope asphericity and the best compensation distance (BCD) established in our previous work, we propose a SPE measurement method for high-order aspheric surface in partial compensation interferometry (PCI) system. In the procedure, firstly, we establish the system of two element equations by utilizing the SPE-caused BCD change and surface shape change. Then, we can simultaneously obtain the VROC error and CC error in PCI system by solving the equations. Simulations are made to verify the method, and the results show a high relative accuracy.

Modeling the degradation kinetics of ascorbic acid.

PubMed

Peleg, Micha; Normand, Mark D; Dixon, William R; Goulette, Timothy R

2018-06-13

Most published reports on ascorbic acid (AA) degradation during food storage and heat preservation suggest that it follows first-order kinetics. Deviations from this pattern include Weibullian decay, and exponential drop approaching finite nonzero retention. Almost invariably, the degradation rate constant's temperature-dependence followed the Arrhenius equation, and hence the simpler exponential model too. A formula and freely downloadable interactive Wolfram Demonstration to convert the Arrhenius model's energy of activation, E a , to the exponential model's c parameter, or vice versa, are provided. The AA's isothermal and non-isothermal degradation can be simulated with freely downloadable interactive Wolfram Demonstrations in which the model's parameters can be entered and modified by moving sliders on the screen. Where the degradation is known a priori to follow first or other fixed order kinetics, one can use the endpoints method, and in principle the successive points method too, to estimate the reaction's kinetic parameters from considerably fewer AA concentration determinations than in the traditional manner. Freeware to do the calculations by either method has been recently made available on the Internet. Once obtained in this way, the kinetic parameters can be used to reconstruct the entire degradation curves and predict those at different temperature profiles, isothermal or dynamic. Comparison of the predicted concentration ratios with experimental ones offers a way to validate or refute the kinetic model and the assumptions on which it is based.

High Vertically Resolved Atmospheric and Surface/Cloud Parameters Retrieved with Infrared Atmospheric Sounding Interferometer (IASI)

NASA Technical Reports Server (NTRS)

Zhou, Daniel K.; Liu, Xu; Larar, Allen M.; Smith, WIlliam L.; Taylor, Jonathan P.; Schluessel, Peter; Strow, L. Larrabee; Mango, Stephen A.

2008-01-01

The Joint Airborne IASI Validation Experiment (JAIVEx) was conducted during April 2007 mainly for validation of the IASI on the MetOp satellite. IASI possesses an ultra-spectral resolution of 0.25/cm and a spectral coverage from 645 to 2760/cm. Ultra-spectral resolution infrared spectral radiance obtained from near nadir observations provide atmospheric, surface, and cloud property information. An advanced retrieval algorithm with a fast radiative transfer model, including cloud effects, is used for atmospheric profile and cloud parameter retrieval. This physical inversion scheme has been developed, dealing with cloudy as well as cloud-free radiance observed with ultraspectral infrared sounders, to simultaneously retrieve surface, atmospheric thermodynamic, and cloud microphysical parameters. A fast radiative transfer model, which applies to the cloud-free and/or clouded atmosphere, is used for atmospheric profile and cloud parameter retrieval. A one-dimensional (1-d) variational multi-variable inversion solution is used to improve an iterative background state defined by an eigenvector-regression-retrieval. The solution is iterated in order to account for non-linearity in the 1-d variational solution. It is shown that relatively accurate temperature and moisture retrievals are achieved below optically thin clouds. For optically thick clouds, accurate temperature and moisture profiles down to cloud top level are obtained. For both optically thin and thick cloud situations, the cloud top height can be retrieved with relatively high accuracy (i.e., error < 1 km). Preliminary retrievals of atmospheric soundings, surface properties, and cloud optical/microphysical properties with the IASI observations are obtained and presented. These retrievals will be further inter-compared with those obtained from airborne FTS system, such as the NPOESS Airborne Sounder Testbed - Interferometer (NAST-I), dedicated dropsondes, radiosondes, and ground based Raman Lidar. The capabilities of satellite ultra-spectral sounder such as the IASI are investigated indicating a high vertical structure of atmosphere is retrieved.

Airborne gamma-ray spectrometer and magnetometer survey: Weed quadrangle, California. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-05-01

Volume II contains the flight path, radiometric multi-parameter stacked profiles, magnetic and ancillary parameter stacked profiles, histograms, and anomaly maps for the Weed Quadrangle in California.

Higher order string effects and the properties of the Pomeron

DOE PAGES

Kharzeev, Dmitri; Shuryak, Edward; Zahed, Ismail

2018-01-18

In this paper, we revisit the description of the Pomeron within the effective string theory of QCD. Using a string duality relation, we show how the static potential maps onto the high-energy scattering amplitude that exhibits the Pomeron behavior. Besides the Pomeron intercept and slope, new additional terms stemming from the higher order string corrections are shown to affect both the growth of the nucleon’s size at high energies and its profile in impact parameter space. The stringy description also allows for an odderon that only disappears in critical dimension. Lastlyl, some of the Pomeron’s features that emerge within themore » effective string description can be studied at the future EIC collider.« less

Corneal higher-order aberrations and higher-order Strehl ratio after aberration-free ablation profile to treat compound myopic astigmatism.

PubMed

Brenner, Luis F

2015-12-01

To evaluate the changes in corneal higher-order aberrations (HOAs) and their impact on corneal higher-order Strehl ratio after aberration-free ablation profile. Verter Institute, H. Olhos, São Paulo, Brazil. Prospective interventional study. Eyes that had aberration-free myopic ablation were divided into 3 groups, based on the spherical equivalent (SE). The corneal HOAs and higher-order Strehl ratios were calculated before surgery and 3 months after surgery. The postoperative uncorrected-distance visual acuity, corrected-distance visual acuity, and SE did not present statistical differences among groups (88 eyes, P > .05). For a 6 mm pupil, the corneal HOA showed a mean increase of 0.17 μm (range 0.39 to 0.56 μm) (P < .001) and the corneal higher-order Strehl ratio presented a reduction of 0.03 (from 0.25 to 0.22) (P = .001). The following consistent linear predictive model was obtained: corneal HOA induction = 1.474 - 0.032 × SE - 0.225 × OZ, where OZ is the optical zone (R(2) = 0.49, adjusted R(2) = 0.48, P < .001). The corneal HOAs and the higher-order Strehl ratios deteriorated after moderate and high myopic ablations. The worsening in corneal aberrations and optical quality were related to the magnitude of the intended correction and did not affect high-contrast visual performance. The OZ was the only modifiable parameter capable to restrain the optical quality loss. The author has no financial or proprietary interest in any material or method mentioned. Copyright © 2015 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Avalanches and scaling collapse in the large-N Kuramoto model

NASA Astrophysics Data System (ADS)

Coleman, J. Patrick; Dahmen, Karin A.; Weaver, Richard L.

2018-04-01

We study avalanches in the Kuramoto model, defined as excursions of the order parameter due to ephemeral episodes of synchronization. We present scaling collapses of the avalanche sizes, durations, heights, and temporal profiles, extracting scaling exponents, exponent relations, and scaling functions that are shown to be consistent with the scaling behavior of the power spectrum, a quantity independent of our particular definition of an avalanche. A comprehensive scaling picture of the noise in the subcritical finite-N Kuramoto model is developed, linking this undriven system to a larger class of driven avalanching systems.

The use of radar and visual observations to characterize the surface structure of the planet Mercury

NASA Technical Reports Server (NTRS)

Clark, P. E.; Kobrick, M.; Jurgens, R. F.

1985-01-01

An analysis is conducted of available topographic profiles and scattering parameters derived from earth-based S- and X-band radar observations of Mercury, in order to determine the nature and origin of regional surface variations and structures that are typical of the planet. Attention is given to the proposal that intercrater plains on Mercury formed from extensive volcanic flooding during bombardment, so that most craters were formed on a partially molten surface and were thus obliterated, together with previously formed tectonic features.

Wavelets solution of MHD 3-D fluid flow in the presence of slip and thermal radiation effects

NASA Astrophysics Data System (ADS)

Usman, M.; Zubair, T.; Hamid, M.; Haq, Rizwan Ul; Wang, Wei

2018-02-01

This article is devoted to analyze the magnetic field, slip, and thermal radiations effects on generalized three-dimensional flow, heat, and mass transfer in a channel of lower stretching wall. We supposed two various lateral direction rates for the lower stretching surface of the wall while the upper wall of the channel is subjected to constant injection. Moreover, influence of thermal slip on the temperature profile beside the viscous dissipation and Joule heating is also taken into account. The governing set of partial differential equations of the heat transfer and flow are transformed to nonlinear set of ordinary differential equations (ODEs) by using the compatible similarity transformations. The obtained nonlinear ODE set tackled by means of a new wavelet algorithm. The outcomes obtained via modified Chebyshev wavelet method are compared with Runge-Kutta (order-4). The worthy comparison, error, and convergence analysis shows an excellent agreement. Additionally, the graphical representation for various physical parameters including the skin friction coefficient, velocity, the temperature gradient, and the temperature profiles are plotted and discussed. It is observed that for a fixed value of velocity slip parameter a suitable selection of stretching ratio parameter can be helpful in hastening the heat transfer rate and in reducing the viscous drag over the stretching sheet. Finally, the convergence analysis is performed which endorsing that this proposed method is well efficient.

Experimental Study of the Structure of a Wingtip Vortex

NASA Technical Reports Server (NTRS)

Anderson, Elgin A.; Wright, Christopher T.

2000-01-01

A complete look at the near-field development and subsequent role-up of a wingtip vortex from a NACA 0015 wing section is investigated. Two separate but equally important surveys of the vortex structure in the region adjacent to the wingtip and approximately one chord length downstream of the trailing edge are performed. The two surveys provide qualitative flow-visualization an quantitative velocity measurement data. The near-field development and subsequent role-up of the vortex structures is strongly influenced by the angle-of-attack and the end-cap treatment of the wing section. The velocity field near the wingtip of the NACA 0015 wing section was measured with a triple-sensor hot wire probe and compared to flow visualization images produced with titanium tetrachloride smoke injection and laser illumination. The flat end-cap results indicate the formation of multiple, relatively strong vortex structures as opposed to the formation of a single vortex produced with the round end-cap. The multiple vortices generated by the flat end-cap are seen to rotate around a common ce te in a helical pattern until they eventually merge into a single vortex. Compared to a non-dimensional loading parameter, the results of the velocity and flow visualization data shows a "jetlike" axial velocity profile for loading parameter values on the order of 0.1 and a "wakelike" profile for much lower loading parameter values.

Analytical solution of concentric two-pole Halbach cylinders as a preliminary design tool for magnetic refrigeration systems

NASA Astrophysics Data System (ADS)

Fortkamp, F. P.; Lozano, J. A.; Barbosa, J. R.

2017-12-01

This work presents a parametric analysis of the performance of nested permanent magnet Halbach cylinders intended for applications in magnetic refrigeration and heat pumping. An analytical model for the magnetic field generated by the cylinders is used to systematically investigate the influence of their geometric parameters. The proposed configuration generates two poles in the air gap between the cylinders, where active magnetic regenerators are positioned for conversion of magnetic work into cooling capacity or heat power. A sample geometry based on previous designs of magnetic refrigerators is investigated, and the results show that the magnetic field in the air gap oscillates between 0 to approximately 1 T, forming a rectified cosine profile along the circumference of the gap. Calculations of the energy density of the magnets indicate the need to operate at a low energy (particular the inner cylinder) in order to generate a magnetic profile suitable for a magnetic cooler. In practice, these low-energy regions of the magnet can be potentially replaced by soft ferromagnetic material. A parametric analysis of the air gap height has been performed, showing that there are optimal values which maximize the magnet efficiency parameter Λcool . Some combinations of cylinder radii resulted in magnetic field changes that were too small for practical purposes. No demagnetization of the cylinders has been found for the range of parameters considered.

Effective one-dimensional approach to the source reconstruction problem of three-dimensional inverse optoacoustics

NASA Astrophysics Data System (ADS)

Stritzel, J.; Melchert, O.; Wollweber, M.; Roth, B.

2017-09-01

The direct problem of optoacoustic signal generation in biological media consists of solving an inhomogeneous three-dimensional (3D) wave equation for an initial acoustic stress profile. In contrast, the more defiant inverse problem requires the reconstruction of the initial stress profile from a proper set of observed signals. In this article, we consider an effectively 1D approach, based on the assumption of a Gaussian transverse irradiation source profile and plane acoustic waves, in which the effects of acoustic diffraction are described in terms of a linear integral equation. The respective inverse problem along the beam axis can be cast into a Volterra integral equation of the second kind for which we explore here efficient numerical schemes in order to reconstruct initial stress profiles from observed signals, constituting a methodical progress of computational aspects of optoacoustics. In this regard, we explore the validity as well as the limits of the inversion scheme via numerical experiments, with parameters geared toward actual optoacoustic problem instances. The considered inversion input consists of synthetic data, obtained in terms of the effectively 1D approach, and, more generally, a solution of the 3D optoacoustic wave equation. Finally, we also analyze the effect of noise and different detector-to-sample distances on the optoacoustic signal and the reconstructed pressure profiles.

Comparative study of quantitative phase imaging techniques for refractometry of optical fibers

NASA Astrophysics Data System (ADS)

de Dorlodot, Bertrand; Bélanger, Erik; Bérubé, Jean-Philippe; Vallée, Réal; Marquet, Pierre

2018-02-01

The refractive index difference profile of optical fibers is the key design parameter because it determines, among other properties, the insertion losses and propagating modes. Therefore, an accurate refractive index profiling method is of paramount importance to their development and optimization. Quantitative phase imaging (QPI) is one of the available tools to retrieve structural characteristics of optical fibers, including the refractive index difference profile. Having the advantage of being non-destructive, several different QPI methods have been developed over the last decades. Here, we present a comparative study of three different available QPI techniques, namely the transport-of-intensity equation, quadriwave lateral shearing interferometry and digital holographic microscopy. To assess the accuracy and precision of those QPI techniques, quantitative phase images of the core of a well-characterized optical fiber have been retrieved for each of them and a robust image processing procedure has been applied in order to retrieve their refractive index difference profiles. As a result, even if the raw images for all the three QPI methods were suffering from different shortcomings, our robust automated image-processing pipeline successfully corrected these. After this treatment, all three QPI techniques yielded accurate, reliable and mutually consistent refractive index difference profiles in agreement with the accuracy and precision of the refracted near-field benchmark measurement.

Association of Ambulatory Blood Pressure Monitoring parameters with the Framingham Stroke Risk Profile.

PubMed

Tsivgoulis, Georgios; Pikilidou, Maria; Katsanos, Aristeidis H; Stamatelopoulos, Kimon; Michas, Fotios; Lykka, Aikaterini; Zompola, Christina; Filippatou, Angeliki; Boviatsis, Efstathios; Voumvourakis, Konstantinos; Zakopoulos, Nikolaos; Manios, Efstathios

2017-09-15

The Framingham Stroke Risk Profile (FSRP) is a novel and reliable tool for estimating the 10-year probability for incident stroke in stroke-free individuals, while the predictive value of ambulatory blood pressure monitoring (ABPM) for first-ever and recurrent stroke has been well established. We sought to evaluate cross-sectionally the association of ABPM parameters with FSRP score in a large sample of 2343 consecutive stroke-free individuals (mean age: 56.0±12.9, 49.1% male) who underwent 24-hour ABPM. True hypertensives showed significantly higher FSRP (11.2±5.0) compared to the normotensives (8.2±5.0, p<0.001), while subjects with white coat hypertension also had higher FSRP (10.2±4.7) than normotensives (8.2±5.0, p<0.001). Compared to dippers that exhibited the lowest FSRP, non-dippers and reverse-dippers exhibited significantly higher FSRP (9.8±4.8 for dippers vs 10.6±5.2 and 11.5±5.0 for non-dippers and reverse-dippers respectively, p≤0.001 for comparisons). In univariate analyses, the ABPM parameters that had the strongest correlation with FSRP were 24-hour (r=0.440, p<0.001), daytime (r=0.435, p<0.001) and night-time (r=0.423; p<0.001) pulse pressure (PP). The best fitting model for predicting FSRP (R 2 =24.6%) on multiple linear regression analyses after adjustment for vascular risk factors not included in FSRP comprised the following parameters in descending order: 24-hour PP (β=0.349, p<0.001), daytime SBP variability (β=0.124, p<0.001), 24-hour HR variability (β=-0.091, p<0.001), mean 24-hour HR (β=-0.107, p<0.001), BMI (β=0.081, p<0.001) and dipping percentage (β=-0.063, p=0.001). 24-hour PP and daytime SBP variability are the two ABPM parameters that were more strongly associated with FSRP-score. Reverse dippers had the highest FSRP among all dipping status profiles. Copyright © 2017 Elsevier B.V. All rights reserved.

Multiplexing a high-throughput liability assay to leverage efficiencies.

PubMed

Herbst, John; Anthony, Monique; Stewart, Jeremy; Connors, David; Chen, Taosheng; Banks, Martyn; Petrillo, Edward W; Agler, Michele

2009-06-01

In order to identify potential cytochrome P-450 3A4 (drug-metabolizing enzyme) inducers at an early stage of the drug discovery process, a cell-based transactivation high-throughput luciferase reporter assay for the human pregnane X receptor (PXR) in HepG2 cells has been implemented and multiplexed with a viability end point for data interpretation, as part of a Lead Profiling portfolio of assays. As a routine part of Lead Profiling operations, assays are periodically evaluated for utility as well as for potential improvements in technology or process. We used a recent evaluation of our PXR-transactivation assay as a model for the application of Lean Thinking-based process analysis to lab-bench assay optimization and automation. This resulted in the development of a 384-well multiplexed homogeneous assay simultaneously detecting PXR transactivation and HepG2 cell cytotoxicity. In order to multiplex fluorescent and luminescent read-outs, modifications to each assay were necessary, which included optimization of multiple assay parameters such as cell density, plate type, and reagent concentrations. Subsequently, a set of compounds including known cytotoxic compounds and PXR inducers were used to validate the multiplexed assay. Results from the multiplexed assay correlate well with those from the singleplexed assay formats measuring PXR transactivation and viability separately. Implementation of the multiplexed assay for routine compound profiling provides improved data quality, sample conservation, cost savings, and resource efficiencies.

Effect of exponential density transition on self-focusing of q-Gaussian laser beam in collisionless plasma

NASA Astrophysics Data System (ADS)

Valkunde, Amol T.; Vhanmore, Bandopant D.; Urunkar, Trupti U.; Gavade, Kusum M.; Patil, Sandip D.; Takale, Mansing V.

2018-05-01

In this work, nonlinear aspects of a high intensity q-Gaussian laser beam propagating in collisionless plasma having upward density ramp of exponential profiles is studied. We have employed the nonlinearity in dielectric function of plasma by considering ponderomotive nonlinearity. The differential equation governing the dimensionless beam width parameter is achieved by using Wentzel-Kramers-Brillouin (WKB) and paraxial approximations and solved it numerically by using Runge-Kutta fourth order method. Effect of exponential density ramp profile on self-focusing of q-Gaussian laser beam for various values of q is systematically carried out and compared with results Gaussian laser beam propagating in collisionless plasma having uniform density. It is found that exponential plasma density ramp causes the laser beam to become more focused and gives reasonably interesting results.

A study of the feasibility of ultraviolet spectrometry for cometary missions

NASA Technical Reports Server (NTRS)

Feldman, P. D.

1979-01-01

Ultraviolet spectra fo the comet West obtained by sounding rocket experiments in 1976 are reproduced and interpreted in order to estimate the expected brightness of the emission features and determine the spatial extent of these features for the proposed Halley Flyby/Tempel 2 rendezvous and the possible Halley or Encke flybys close to perihelion. A coma model was constructed and evaluated for the physical condition of candidate targets such as heliocentric distance, gas production, and composition. In addition to brightness profiles, the neutral and ion densities of the principal species are also dervied. The brightness profiles can be used to determine the feasibility of utilizing the space telescope to provide supporting observations during the mission. Basic parameters identified are spectral range, wavelength resolution, spatial resolution, sensitivity and dynamic range, rejection of scattered light, and integration or accumulation time.

Luminescence profiling of loess-dominated archaeological layers of a Chalcolithic site, Northern Negev Desert fringe, Israel

NASA Astrophysics Data System (ADS)

López, Gloria I.; Roskin, Joel; Bee'ri, Ron

2017-04-01

This study applies a pulsed-photon Portable OSL Reader (PPSL) in investigating the palaeoenviroment and stages of development of a Chalcolithic site revealed during a salvage excavation. The (Shoqet Junction) site, within late Pleistocene loess-dominated sediment, is adjacent to the meandering and ephemeral Hebron Wadi in the Beer-Sheva Valley, at the fringe of the Northern Negev Desert (Israel). The site intermittently covers approximately 8 hectares and was exposed at 0.3 - 0.5 m depths beneath a plowed field. Five areas were excavated down to 4 meters. The site was dominated by an array of underground facilities: tunnels, (capped) shafts, walls, floors and infilled cavities were found within four main layers. The site includes a mixture of sediments: large amounts of organic material, weathered bricks, a powdery loess-like unit and thin Bk horizons. The artifact assemblage is associated with the Ghassulian culture. The objectives of this multi-parameter study, which combines PPSL luminescence profiling with sedimentological and geomorphic analyses, are to (1) analyze the Chalcolithic palaeoenvironments, aeolian and fluvial processes and location and morphology of streambeds, (2) identify possible deterministic physical influences upon the occupations (3) decipher the natural stratigraphic archive and discriminate between human and natural (aeolian/fluvial) induced sedimentation (4) create relative age profiles based on portable OSL measurements and OSL ages, in order to minimize OSL dating. Three main sections were profiled: a natural section - in order to identify the natural sedimentological regime and two walls of two excavation squares down to the sites' alluvial base. A small section above a prominent Bk horizon was also profiled. Altogether 58 samples were obtained for sediment and PPSL analyses. Luminescence profiles in general fit the stratigraphic breaks and enable discrimination between layers. Plowed and surface loess give low reads. Inverse reads along the profile are partly understood to be due to anthropogenic intervention with the sediment. The study highlights the potential and some of the complexities involved with portable OSL profiling of multi-layer prehistoric sites.

Improving the particle beam characteristics resulting from laser ion acceleration at ultra high intensity through target manipulation - Numerical modeling

NASA Astrophysics Data System (ADS)

Tatomirescu, Dragos; d'Humieres, Emmanuel; Vizman, Daniel

2017-12-01

The necessity to produce superior quality ion and electron beams has been a hot research field due to the advances in laser science in the past decade. This work focuses on the parametric study of different target density profiles in order to determine their effect on the spatial distribution of the accelerated particle beam, the particle maximum energy, and the electromagnetic field characteristics. For the scope of this study, the laser pulse parameters were kept constant, while varying the target parameters. The study continues the work published in [1] and focuses on further studying the effects of target curvature coupled with a cone laser focusing structure. The results show increased particle beam focusing and a significant enhancement in particle maximum energy.

Dynamics of nonautonomous discrete rogue wave solutions for an Ablowitz-Musslimani equation with PT-symmetric potential.

PubMed

Yu, Fajun

2017-02-01

Starting from a discrete spectral problem, we derive a hierarchy of nonlinear discrete equations which include the Ablowitz-Ladik (AL) equation. We analytically study the discrete rogue-wave (DRW) solutions of AL equation with three free parameters. The trajectories of peaks and depressions of profiles for the first- and second-order DRWs are produced by means of analytical and numerical methods. In particular, we study the solutions with dispersion in parity-time ( PT) symmetric potential for Ablowitz-Musslimani equation. And we consider the non-autonomous DRW solutions, parameters controlling and their interactions with variable coefficients, and predict the long-living rogue wave solutions. Our results might provide useful information for potential applications of synthetic PT symmetric systems in nonlinear optics and condensed matter physics.

Cross diffusion effect on MHD mixed convection flow of nonlinear radiative heat and mass transfer of Casson fluid over a vertical plate

NASA Astrophysics Data System (ADS)

Ganesh Kumar, K.; Archana, M.; Gireesha, B. J.; Krishanamurthy, M. R.; Rudraswamy, N. G.

2018-03-01

A study on magnetohydrodynamic mixed convection flow of Casson fluid over a vertical plate has been modelled in the presence of Cross diffusion effect and nonlinear thermal radiation. The governing partial differential equations are remodelled into ordinary differential equations by using similarity transformation. The accompanied differential equations are resolved numerically by using Runge-Kutta-Fehlberg forth-fifth order along with shooting method (RKF45 Method). The results of various physical parameters on velocity and temperature profiles are given diagrammatically. The numerical values of the local skin friction coefficient, local Nusselt number and local Sherwood number also are shown in a tabular form. It is found that, effect of Dufour and Soret parameter increases the temperature and concentration component correspondingly.

End-of-Discharge and End-of-Life Prediction in Lithium-Ion Batteries with Electrochemistry-Based Aging Models

NASA Technical Reports Server (NTRS)

Daigle, Matthew; Kulkarni, Chetan S.

2016-01-01

As batteries become increasingly prevalent in complex systems such as aircraft and electric cars, monitoring and predicting battery state of charge and state of health becomes critical. In order to accurately predict the remaining battery power to support system operations for informed operational decision-making, age-dependent changes in dynamics must be accounted for. Using an electrochemistry-based model, we investigate how key parameters of the battery change as aging occurs, and develop models to describe aging through these key parameters. Using these models, we demonstrate how we can (i) accurately predict end-of-discharge for aged batteries, and (ii) predict the end-of-life of a battery as a function of anticipated usage. The approach is validated through an experimental set of randomized discharge profiles.

Topological Fulde-Ferrell and Larkin-Ovchinnikov states in spin-orbit-coupled lattice system

NASA Astrophysics Data System (ADS)

Guo, Yao-Wu; Chen, Yan

2018-04-01

The spin-orbit coupled lattice system under Zeeman fields provides an ideal platform to realize exotic pairing states. Notable examples range from the topological superfluid/superconducting (tSC) state, which is gapped in the bulk but metallic at the edge, to the Fulde-Ferrell (FF) state (having a phase-modulated order parameter with a uniform amplitude) and the Larkin-Ovchinnikov (LO) state (having a spatially varying order parameter amplitude). Here, we show that the topological FF state with Chern number ( C = -1) (tFF1) and topological LO state with C= 2 (tLO2) can be stabilized in Rashba spin-orbit coupled lattice systems in the presence of both in-plane and out-of-plane Zeeman fields. Besides the inhomogeneous tSC states, in the presence of a weak in-plane Zeeman field, two topological BCS phases may emerge with C = -1 (tBCS1) far from half filling and C = 2 (tBCS2) near half filling. We show intriguing effects such as different spatial profiles of order parameters for FF and LO states, the topological evolution among inhomogeneous tSC states, and different non-trivial Chern numbers for the tFF1 and tLO1,2 states, which are peculiar to the lattice system. Global phase diagrams for various topological phases are presented for both half-filling and doped cases. The edge states as well as local density of states spectra are calculated for tSC states in a 2D strip.

Comparing emerging and mature markets during times of crises: A non-extensive statistical approach

NASA Astrophysics Data System (ADS)

Namaki, A.; Koohi Lai, Z.; Jafari, G. R.; Raei, R.; Tehrani, R.

2013-07-01

One of the important issues in finance and economics for both scholars and practitioners is to describe the behavior of markets, especially during times of crises. In this paper, we analyze the behavior of some mature and emerging markets with a Tsallis entropy framework that is a non-extensive statistical approach based on non-linear dynamics. During the past decade, this technique has been successfully applied to a considerable number of complex systems such as stock markets in order to describe the non-Gaussian behavior of these systems. In this approach, there is a parameter q, which is a measure of deviation from Gaussianity, that has proved to be a good index for detecting crises. We investigate the behavior of this parameter in different time scales for the market indices. It could be seen that the specified pattern for q differs for mature markets with regard to emerging markets. The findings show the robustness of the stated approach in order to follow the market conditions over time. It is obvious that, in times of crises, q is much greater than in other times. In addition, the response of emerging markets to global events is delayed compared to that of mature markets, and tends to a Gaussian profile on increasing the scale. This approach could be very useful in application to risk and portfolio management in order to detect crises by following the parameter q in different time scales.

Analysis of residual transverse stresses in a thick UD glass/polyester pultruded profile using hole drilling with strain gage and digital image correlation

NASA Astrophysics Data System (ADS)

Yuksel, Onur; Baran, Ismet; Ersoy, Nuri; Akkerman, Remko

2018-05-01

Process induced stresses inherently exist in fiber reinforced polymer composites particularly in thick parts due to the presence of non-uniform cure, shrinkage and thermal expansion/contraction during manufacturing. In order to increase the reliability and the performance of the composite materials, process models are developed to predict the residual stress formation. The accuracy of the process models is dependent on the geometrical (micro to macro), material and process parameters as well as the numerical implementation. Therefore, in order to have reliable process modelling framework, there is a need for validation and if necessary calibration of the developed models. This study focuses on measurement of the transverse residual stresses in a relatively thick pultruded profile (20×20 mm) made of glass/polyester. Process-induced residual stresses in the middle of the profile are examined with different techniques which have never been applied for transverse residual stresses in thick unidirectional composites. Hole drilling method with strain gage and digital image correlation are employed. Strain values measured from measurements are used in a finite element model (FEM) to simulate the hole drilling process and predict the residual stress level. The measured released strain is found to be approximately 180 μm/m from the strain gage. The tensile residual stress at the core of the profile is estimated approximately as 7-10 MPa. Proposed methods and measured values in this study will enable validation and calibration of the process models based on the residual stresses.

Vertical radar profiles for the calibration of unsaturated flow models under dynamic water table conditions

NASA Astrophysics Data System (ADS)

Cassiani, G.; Gallotti, L.; Ventura, V.; Andreotti, G.

2003-04-01

The identification of flow and transport characteristics in the vadose zone is a fundamental step towards understanding the dynamics of contaminated sites and the resulting risk of groundwater pollution. Borehole radar has gained popularity for the monitoring of moisture content changes, thanks to its apparent simplicity and its high resolution characteristics. However, cross-hole radar requires closely spaced (a few meters), plastic-cased boreholes, that are rarely available as a standard feature in sites of practical interest. Unlike cross-hole applications, Vertical Radar Profiles (VRP) require only one borehole, with practical and financial benefits. High-resolution, time-lapse VRPs have been acquired at a crude oil contaminated site in Trecate, Northern Italy, on a few existing boreholes originally developed for remediation via bioventing. The dynamic water table conditions, with yearly oscillations of roughly 5 m from 6 to 11 m bgl, offers a good opportunity to observe via VRP a field scale drainage-imbibition process. Arrival time inversion has been carried out using a regularized tomographic algorithm, in order to overcome the noise introduced by first arrival picking. Interpretation of the vertical profiles in terms of moisture content has been based on standard models (Topp et al., 1980; Roth et al., 1990). The sedimentary sequence manifests itself as a cyclic pattern in moisture content over most of the profiles. We performed preliminary Richards' equation simulations with time varying later table boundary conditions, in order to estimate the unsaturated flow parameters, and the results have been compared with laboratory evidence from cores.

Aromaticity Parameters in Asphalt Binders Calculated From Profile Fitting X-ray Line Spectra Using Pearson VII and Pseudo-Voigt Functions

NASA Astrophysics Data System (ADS)

Shirokoff, J.; Lewis, J. Courtenay

2010-10-01

The aromaticity and crystallite parameters in asphalt binders are calculated from data obtained after profile fitting x-ray line spectra using Pearson VII and pseudo-Voigt functions. The results are presented and discussed in terms of the peak profile fit parameters used, peak deconvolution procedure, and differences in calculated values that can arise owing to peak shape and additional peaks present in the pattern. These results have implications concerning the evaluation and performance of asphalt binders used in highways and road applications.

Doppler Feature Based Classification of Wind Profiler Data

NASA Astrophysics Data System (ADS)

Sinha, Swati; Chandrasekhar Sarma, T. V.; Lourde. R, Mary

2017-01-01

Wind Profilers (WP) are coherent pulsed Doppler radars in UHF and VHF bands. They are used for vertical profiling of wind velocity and direction. This information is very useful for weather modeling, study of climatic patterns and weather prediction. Observations at different height and different wind velocities are possible by changing the operating parameters of WP. A set of Doppler power spectra is the standard form of WP data. Wind velocity, direction and wind velocity turbulence at different heights can be derived from it. Modern wind profilers operate for long duration and generate approximately 4 megabytes of data per hour. The radar data stream contains Doppler power spectra from different radar configurations with echoes from different atmospheric targets. In order to facilitate systematic study, this data needs to be segregated according the type of target. A reliable automated target classification technique is required to do this job. Classical techniques of radar target identification use pattern matching and minimization of mean squared error, Euclidean distance etc. These techniques are not effective for the classification of WP echoes, as these targets do not have well-defined signature in Doppler power spectra. This paper presents an effective target classification technique based on range-Doppler features.

The MONET code for the evaluation of the dose in hadrontherapy

NASA Astrophysics Data System (ADS)

Embriaco, A.

2018-01-01

The MONET is a code for the computation of the 3D dose distribution for protons in water. For the lateral profile, MONET is based on the Molière theory of multiple Coulomb scattering. To take into account also the nuclear interactions, we add to this theory a Cauchy-Lorentz function, where the two parameters are obtained by a fit to a FLUKA simulation. We have implemented the Papoulis algorithm for the passage from the projected to a 2D lateral distribution. For the longitudinal profile, we have implemented a new calculation of the energy loss that is in good agreement with simulations. The inclusion of the straggling is based on the convolution of energy loss with a Gaussian function. In order to complete the longitudinal profile, also the nuclear contributions are included using a linear parametrization. The total dose profile is calculated in a 3D mesh by evaluating at each depth the 2D lateral distributions and by scaling them at the value of the energy deposition. We have compared MONET with FLUKA in two cases: a single Gaussian beam and a lateral scan. In both cases, we have obtained a good agreement for different energies of protons in water.

Laser Fluence Recognition Using Computationally Intelligent Pulsed Photoacoustics Within the Trace Gases Analysis

NASA Astrophysics Data System (ADS)

Lukić, M.; Ćojbašić, Ž.; Rabasović, M. D.; Markushev, D. D.; Todorović, D. M.

2017-11-01

In this paper, the possibilities of computational intelligence applications for trace gas monitoring are discussed. For this, pulsed infrared photoacoustics is used to investigate SF6-Ar mixtures in a multiphoton regime, assisted by artificial neural networks. Feedforward multilayer perceptron networks are applied in order to recognize both the spatial characteristics of the laser beam and the values of laser fluence Φ from the given photoacoustic signal and prevent changes. Neural networks are trained in an offline batch training regime to simultaneously estimate four parameters from theoretical or experimental photoacoustic signals: the laser beam spatial profile R(r), vibrational-to-translational relaxation time τ _{V-T} , distance from the laser beam to the absorption molecules in the photoacoustic cell r* and laser fluence Φ . The results presented in this paper show that neural networks can estimate an unknown laser beam spatial profile and the parameters of photoacoustic signals in real time and with high precision. Real-time operation, high accuracy and the possibility of application for higher intensities of radiation for a wide range of laser fluencies are factors that classify the computational intelligence approach as efficient and powerful for the in situ measurement of atmospheric pollutants.

Reactive Burn Model Calibration for PETN Using Ultra-High-Speed Phase Contrast Imaging

NASA Astrophysics Data System (ADS)

Johnson, Carl; Ramos, Kyle; Bolme, Cindy; Sanchez, Nathaniel; Barber, John; Montgomery, David

2017-06-01

A 1D reactive burn model (RBM) calibration for a plastic bonded high explosive (HE) requires run-to-detonation data. In PETN (pentaerythritol tetranitrate, 1.65 g/cc) the shock to detonation transition (SDT) is on the order of a few millimeters. This rapid SDT imposes experimental length scales that preclude application of traditional calibration methods such as embedded electromagnetic gauge methods (EEGM) which are very effective when used to study 10 - 20 mm thick HE specimens. In recent work at Argonne National Laboratory's Advanced Photon Source we have obtained run-to-detonation data in PETN using ultra-high-speed dynamic phase contrast imaging (PCI). A reactive burn model calibration valid for 1D shock waves is obtained using density profiles spanning the transition to detonation as opposed to particle velocity profiles from EEGM. Particle swarm optimization (PSO) methods were used to operate the LANL hydrocode FLAG iteratively to refine SURF RBM parameters until a suitable parameter set attained. These methods will be presented along with model validation simulations. The novel method described is generally applicable to `sensitive' energetic materials particularly those with areal densities amenable to radiography.

UNDERSTANDING THE STRUCTURE OF THE HOT INTERSTELLAR MEDIUM IN NORMAL EARLY-TYPE GALAXIES.

NASA Astrophysics Data System (ADS)

Traynor, Liam; Kim, Dong-Woo; Chandra Galaxy Atlas

2018-01-01

The hot interstellar medium (ISM) of early-type galaxies (ETG's) provides crucial insight into the understanding of their formation and evolution. Mechanisms such as type Ia supernovae heating, AGN feedback, deepening potential depth through dark matter assembly and ramp-pressure stripping are known to affect the structure of the ISM. By using temperature maps and radial temperature profiles of the hot ISM from ~70 ETG's with archival Chandra data, it is possible to classify the galaxy's ISM into common structural types. This is extended by using 3D fitting of the radial temperature profile in order to provide models that further constrain the structural types. Five structural types are present, negative (temperature decreases with radii), positive (temperature increases with radii), hybrid-dip (temperature decreases at small radii and increases at large radii), hybrid-bump (inverse of hybrid-dip) and quasi-isothermal (temperature is constant at all radii). This work will be continued by 1) determining which mechanisms are present in which galaxies and 2) analysing the model parameters between galaxies within each structural type to determine whether each type can be described by a single set of model parameters, indicating that the same physical processes are responsible for creating that structural type.

The segmented non-uniform dielectric module design for uniformity control of plasma profile in a capacitively coupled plasma chamber

NASA Astrophysics Data System (ADS)

Xia, Huanxiong; Xiang, Dong; Yang, Wang; Mou, Peng

2014-12-01

Low-temperature plasma technique is one of the critical techniques in IC manufacturing process, such as etching and thin-film deposition, and the uniformity greatly impacts the process quality, so the design for the plasma uniformity control is very important but difficult. It is hard to finely and flexibly regulate the spatial distribution of the plasma in the chamber via controlling the discharge parameters or modifying the structure in zero-dimensional space, and it just can adjust the overall level of the process factors. In the view of this problem, a segmented non-uniform dielectric module design solution is proposed for the regulation of the plasma profile in a CCP chamber. The solution achieves refined and flexible regulation of the plasma profile in the radial direction via configuring the relative permittivity and the width of each segment. In order to solve this design problem, a novel simulation-based auto-design approach is proposed, which can automatically design the positional sequence with multi independent variables to make the output target profile in the parameterized simulation model approximate the one that users preset. This approach employs an idea of quasi-closed-loop control system, and works in an iterative mode. It starts from initial values of the design variable sequences, and predicts better sequences via the feedback of the profile error between the output target profile and the expected one. It never stops until the profile error is narrowed in the preset tolerance.

A data driven nonlinear stochastic model for blood glucose dynamics.

PubMed

Zhang, Yan; Holt, Tim A; Khovanova, Natalia

2016-03-01

The development of adequate mathematical models for blood glucose dynamics may improve early diagnosis and control of diabetes mellitus (DM). We have developed a stochastic nonlinear second order differential equation to describe the response of blood glucose concentration to food intake using continuous glucose monitoring (CGM) data. A variational Bayesian learning scheme was applied to define the number and values of the system's parameters by iterative optimisation of free energy. The model has the minimal order and number of parameters to successfully describe blood glucose dynamics in people with and without DM. The model accounts for the nonlinearity and stochasticity of the underlying glucose-insulin dynamic process. Being data-driven, it takes full advantage of available CGM data and, at the same time, reflects the intrinsic characteristics of the glucose-insulin system without detailed knowledge of the physiological mechanisms. We have shown that the dynamics of some postprandial blood glucose excursions can be described by a reduced (linear) model, previously seen in the literature. A comprehensive analysis demonstrates that deterministic system parameters belong to different ranges for diabetes and controls. Implications for clinical practice are discussed. This is the first study introducing a continuous data-driven nonlinear stochastic model capable of describing both DM and non-DM profiles. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Characterisation of case depth in induction-hardened medium carbon steels based on magnetic minor hysteresis loop measurement technique

NASA Astrophysics Data System (ADS)

He, Cunfu; Yang, Meng; Liu, Xiucheng; Wang, Xueqian; Wu, Bin

2017-11-01

The magnetic hysteresis behaviours of ferromagnetic materials vary with the heat treatment-induced micro-structural changes. In the study, the minor hysteresis loop measurement technique was used to quantitatively characterise the case depth in two types of medium carbon steels. Firstly, high-frequency induction quenching was applied in rod samples to increase the volume fraction of hard martensite to the soft ferrite/pearlite (or sorbite) in the sample surface. In order to determine the effective and total case depth, a complementary error function was employed to fit the measured hardness-depth profiles of induction-hardened samples. The cluster of minor hysteresis loops together with the tangential magnetic field (TMF) were recorded from all the samples and the comparative study was conducted among three kinds of magnetic parameters, which were sensitive to the variation of case depth. Compared to the parameters extracted from an individual minor loop and the distortion factor of the TMF, the magnitude of three-order harmonic of TMF was more suitable to indicate the variation in case depth. Two new minor-loop coefficients were introduced by combining two magnetic parameters with cumulative statistics of the cluster of minor-loops. The experimental results showed that the two coefficients monotonically linearly varied with the case depth within the carefully selected magnetisation region.

Sensitivity analysis of the space shuttle to ascent wind profiles

NASA Technical Reports Server (NTRS)

Smith, O. E.; Austin, L. D., Jr.

1982-01-01

A parametric sensitivity analysis of the space shuttle ascent flight to the wind profile is presented. Engineering systems parameters are obtained by flight simulations using wind profile models and samples of detailed (Jimsphere) wind profile measurements. The wind models used are the synthetic vector wind model, with and without the design gust, and a model of the vector wind change with respect to time. From these comparison analyses an insight is gained on the contribution of winds to ascent subsystems flight parameters.

A Semi-Analytical Method for Rapid Estimation of Near-Well Saturation, Temperature, Pressure and Stress in Non-Isothermal CO2 Injection

NASA Astrophysics Data System (ADS)

LaForce, T.; Ennis-King, J.; Paterson, L.

2015-12-01

Reservoir cooling near the wellbore is expected when fluids are injected into a reservoir or aquifer in CO2 storage, enhanced oil or gas recovery, enhanced geothermal systems, and water injection for disposal. Ignoring thermal effects near the well can lead to under-prediction of changes in reservoir pressure and stress due to competition between increased pressure and contraction of the rock in the cooled near-well region. In this work a previously developed semi-analytical model for immiscible, nonisothermal fluid injection is generalised to include partitioning of components between two phases. Advection-dominated radial flow is assumed so that the coupled two-phase flow and thermal conservation laws can be solved analytically. The temperature and saturation profiles are used to find the increase in reservoir pressure, tangential, and radial stress near the wellbore in a semi-analytical, forward-coupled model. Saturation, temperature, pressure, and stress profiles are found for parameters representative of several CO2 storage demonstration projects around the world. General results on maximum injection rates vs depth for common reservoir parameters are also presented. Prior to drilling an injection well there is often little information about the properties that will determine the injection rate that can be achieved without exceeding fracture pressure, yet injection rate and pressure are key parameters in well design and placement decisions. Analytical solutions to simplified models such as these can quickly provide order of magnitude estimates for flow and stress near the well based on a range of likely parameters.

Analysis of heat transfer for unsteady MHD free convection flow of rotating Jeffrey nanofluid saturated in a porous medium

NASA Astrophysics Data System (ADS)

Mohd Zin, Nor Athirah; Khan, Ilyas; Shafie, Sharidan; Alshomrani, Ali Saleh

In this article, the influence of thermal radiation on unsteady magnetohydrodynamics (MHD) free convection flow of rotating Jeffrey nanofluid passing through a porous medium is studied. The silver nanoparticles (AgNPs) are dispersed in the Kerosene Oil (KO) which is chosen as conventional base fluid. Appropriate dimensionless variables are used and the system of equations is transformed into dimensionless form. The resulting problem is solved using the Laplace transform technique. The impact of pertinent parameters including volume fraction φ , material parameters of Jeffrey fluid λ1 , λ , rotation parameter r , Hartmann number Ha , permeability parameter K , Grashof number Gr , Prandtl number Pr , radiation parameter Rd and dimensionless time t on velocity and temperature profiles are presented graphically with comprehensive discussions. It is observed that, the rotation parameter, due to the Coriolis force, tends to decrease the primary velocity but reverse effect is observed in the secondary velocity. It is also observed that, the Lorentz force retards the fluid flow for both primary and secondary velocities. The expressions for skin friction and Nusselt number are also evaluated for different values of emerging parameters. A comparative study with the existing published work is provided in order to verify the present results. An excellent agreement is found.

Unsteady magnetohydrodynamics micropolar fluid in boundary layer flow past a sphere influenced by magnetic fluid

NASA Astrophysics Data System (ADS)

Pratomo, Rizky Verdyanto; Widodo, Basuki; Adzkiya, Dieky

2017-12-01

Research about fluid flow was very interesting because have a lot of advantages and it can be applied in many aspects of life. The study on fluid flow which is now widely studied is on magnetohydrodynamic (MHD). Magnetohydrodynamic is a conductive and electrical in a magnetic field. This paper considers the effect of unsteady magnetic fields on the flow of magneto-hydrodynamic fluid on the boundary layer that flows past a sphere in micropolar fluid influenced by magnetic field. Our approach is as follows. First, we construct a mathematical model and then the system of equations obtained will be solved numerically using the Keller-Box scheme. Then the system is simulated to assess its effect on the fluid flow velocity profile and the profile of microrotation particles. The result of this research indicates, that when the magnetic parameters increase, then velocity profile increases. If material parameters increase, then velocity profile decreases and magnetic parameters increase for n = 0. For n = 0.5, if magnetic parameters increase, then microrotation profile decreases.

Development of near zero-order release dosage forms using three-dimensional printing (3-DP) technology.

PubMed

Wang, Chen-Chao; Tejwani Motwani, Monica R; Roach, Willie J; Kay, Jennifer L; Yoo, Jaedeok; Surprenant, Henry L; Monkhouse, Donald C; Pryor, Timothy J

2006-03-01

Three near zero-order controlled-release pseudoephedrine hydrochloride (PEH) formulations demonstrating proportional release rates were developed using 3-Dimensional Printing (3-DP) technology. Mixtures of Kollidon SR and hydroxypropylmethyl cellulose (HPMC) were used as drug carriers. The release rates were adjusted by varying the Kollidon SR-HPMC ratio while keeping fabrication parameters constant. The dosage forms were composed of an immediate release core and a release rate regulating shell, fabricated with an aqueous PEH and an ethanolic triethyl citrate (TEC) binder, respectively. The dosage form design called for the drug to be released via diffusional pathways formed by HPMC in the shell matrix. The release rate was shown to increase correspondingly with the fraction of HPMC contained in the polymer blend. The designed formulations resulted in dosage forms that were insensitive to changes in pH of the dissolution medium, paddle stirring rate, and the presence/absence of a sinker. The near zero-order release properties were unchanged regardless of the dissolution test being performed on either single cubes or on a group of eight cubes encased within a gelatin capsule shell. The chemical and dissolution properties of the three formulations remained unchanged following 1 month's exposure to 25 degrees C/60% RH or 40 degrees C/75% RH environment under open container condition. The in vivo performance of the three formulations was evaluated using a single-dose, randomized, open-label, four-way crossover clinical study composed of 10 fasted healthy volunteers. The pharmacokinetic parameters were analyzed using a noncompartmental model. Qualitative rank order linear correlations between in vivo absorption profiles and in vitro dissolution parameters (with slope and intercept close to unity and origin, respectively) were obtained for all three formulations, indicating good support for a Level A in vivo/in vitro correlation.

Using Nice-Ohvms Lineshapes to Study Relaxation Rates and Transition Dipole Moments

NASA Astrophysics Data System (ADS)

Hodges, James N.; McCall, Benjamin J.

2016-06-01

Noise Immune Cavity Enhanced Optical Heterodyne Velocity Modulation Spectroscopy (NICE-OHVMS) is a successful technique that we have developed to sensitively, precisely, and accurately record transitions of molecular ions. It has been used exclusively as a method for precise transition frequency measurement via saturation and fitting of the resultant Lamb dips. NICE-OHVMS has been employed to improve the uncertainties on H_3^+, CH_5^+, HeH^+, and OH^+, reducing the transition frequency uncertainties by two orders of magnitude. Because NICE-OHVMS is a saturation technique, this provides a unique opportunity to access information about the ratio of the transition dipole moment to the relaxation rate of the transition. This can be done in two ways, either through comparison of Lamb dip depth to the transition profile or comparison of the absorption intensity and dispersion intensity. Due to the complexity of the modulation scheme, there are many parameters that affect the apparent intensity of the recorded lineshape. A complete understanding of the lineshape is required to make the measurements of interest. Here we present a model that accounts for the heterodyne modulation and velocity modulation, assuming that the fundamental lineshape is represented by a Voigt profile. Fits to data are made and interpreted in order to extract the saturation parameter. K.N. Crabtree et al., Chem. Phys. Lett. 551, 1 (2012). J.N. Hodges et al., J. Chem. Phys. 139, 164201 (2013). A.J. Perry et al., J. Mol. Spectrosc. 317, 71 (2015). A.J. Perry et al., J. Chem. Phys. 141, 101101 (2014). C.R. Marcus et al., Astrophys. J. 817, 138 (2016).

Magnetic Doppler imaging of 53 Camelopardalis in all four Stokes parameters

NASA Astrophysics Data System (ADS)

Kochukhov, O.; Bagnulo, S.; Wade, G. A.; Sangalli, L.; Piskunov, N.; Landstreet, J. D.; Petit, P.; Sigut, T. A. A.

2004-02-01

We present the first investigation of the structure of the stellar surface magnetic field using line profiles in all four Stokes parameters. We extract the information about the magnetic field geometry and abundance distributions of the chemically peculiar star 53 Cam by modelling time-series of high-resolution spectropolarimetric observations with the help of a new magnetic Doppler imaging code. This combination of the unique four Stokes parameter data and state-of-the-art magnetic imaging technique makes it possible to infer the stellar magnetic field topology directly from the rotational variability of the Stokes spectra. In the magnetic imaging of 53 Cam we discard the traditional multipolar assumptions about the structure of magnetic fields in Ap stars and explore the stellar magnetic topology without introducing any global a priori constraints on the field structure. The complex magnetic model of 53 Cam derived with our magnetic Doppler imaging method achieves a good fit to the observed intensity, circular and linear polarization profiles of strong magnetically sensitive Fe II spectral lines. Such an agreement between observations and model predictions was not possible with any earlier multipolar magnetic models, based on modelling Stokes I spectra and fitting surface averaged magnetic observables (e.g., longitudinal field, magnetic field modulus, etc.). Furthermore, we demonstrate that even the direct inversion of the four Stokes parameters of 53 Cam assuming a low-order multipolar magnetic geometry is incapable of achieving an adequate fit to our spectropolarimetric observations. Thus, as a main result of our investigation, we discover that the magnetic field topology of 53 Cam is considerably more complex than any low-order multipolar expansion, raising a general question about the validity of the multipolar assumption in the studies of magnetic field structures of Ap stars. In addition to the analysis of the magnetic field of 53 Cam, we reconstruct surface abundance distributions of Si, Ca, Ti, Fe and Nd. These abundance maps confirm results of the previous studies of 53 Cam, in particular dramatic antiphase variation of Ca and Ti abundances. Based on observations obtained with the Bernard Lyot telescope of the Pic du Midi Observatory and Isaac Newton Telescope of the La Palma Observatory.

The A and m coefficients in the Bruun/Dean equilibrium profile equation seen from the Arctic

USGS Publications Warehouse

Are, F.; Reimnitz, E.

2008-01-01

The Bruun/Dean relation between water depth and distance from the shore with a constant profile shape factor is widely used to describe shoreface profiles in temperate environments. However, it has been shown that the sediment scale parameter (A) and the profile shape factor (m) are interrelated variables. An analysis of 63 Arctic erosional shoreface profiles shows that both coefficients are highly variable. Relative frequency of the average m value is only 16% by the class width 0.1. No other m value frequency exceeds 21%. Therefore, there is insufficient reason to use average m to characterize Arctic shoreface profile shape. The shape of each profile has a definite combination of A and m values. Coefficients A and m show a distinct inverse relationship, as in temperate climate. A dependence of m values on coastal sediment grain size is seen, and m decreases with increasing grain size. With constant m = 0.67, parameter A obtains a dimension unit m1/3. But A equals the water depth in meters 1 m from the water edge. This fact and the variability of parameter m testify that the Bruun/Dean equation is essentially an empirical formula. There is no need to give any measurement unit to parameter A. But the International System of Units (SI) has to be used in applying the Bruun/Dean equation for shoreface profiles. A comparison of the shape of Arctic shoreface profiles with those of temperate environments shows surprising similarity. Therefore, the conclusions reached in this Arctic paper seem to apply also to temperate environments.

Are non-linearity effects of absorption important for MAX-DOAS observations?

NASA Astrophysics Data System (ADS)

Pukite, Janis; Wang, Yang; Wagner, Thomas

2017-04-01

For scattered light observations the absorption optical depth depends non-linearly on the trace gas concentrations if their absorption is strong. This is the case because the Beer-Lambert law is generally not applicable for scattered light measurements due to many (i.e. more than one) light paths contributing to the measurement. While in many cases a linear approximation can be made, for scenarios with strong absorption non-linear effects cannot always be neglected. This is especially the case for observation geometries with spatially extended and diffuse light paths, especially in satellite limb geometry but also for nadir measurements as well. Fortunately the effects of non-linear effects can be quantified by means of expanding the radiative transfer equation in a Taylor series with respect to the trace gas absorption coefficients. Herewith if necessary (1) the higher order absorption structures can be described as separate fit parameters in the DOAS fit and (2) the algorithm constraints of retrievals of VCDs and profiles can be improved by considering higher order sensitivity parameters. In this study we investigate the contribution of the higher order absorption structures for MAX-DOAS observation geometry for different atmospheric and ground properties (cloud and aerosol effects, trace gas amount, albedo) and geometry (different Sun and viewing angles).

Exploiting three kinds of interface propensities to identify protein binding sites.

PubMed

Liu, Bin; Wang, Xiaolong; Lin, Lei; Dong, Qiwen; Wang, Xuan

2009-08-01

Predicting the binding sites between two interacting proteins provides important clues to the function of a protein. In this study, we present a building block of proteins called order profiles to use the evolutionary information of the protein sequence frequency profiles and apply this building block to produce a class of propensities called order profile interface propensities. For comparisons, we revisit the usage of residue interface propensities and binary profile interface propensities for protein binding site prediction. Each kind of propensities combined with sequence profiles and accessible surface areas are inputted into SVM. When tested on four types of complexes (hetero-permanent complexes, hetero-transient complexes, homo-permanent complexes and homo-transient complexes), experimental results show that the order profile interface propensities are better than residue interface propensities and binary profile interface propensities. Therefore, order profile is a suitable profile-level building block of the protein sequences and can be widely used in many tasks of computational biology, such as the sequence alignment, the prediction of domain boundary, the designation of knowledge-based potentials and the protein remote homology detection.

Abelmoschi Corolla non-flavonoid components altered the pharmacokinetic profile of its flavonoids in rat.

PubMed

Lu, Linling; Qian, Dawei; Guo, Jianming; Qian, Yefei; Xu, Boyi; Sha, Mei; Duan, Jinao

2013-07-30

Abelmoschi Corolla is a well-known herbal medicine used for the treatment of chronic renal disease. Flavonoids are the major bioactive ingredients of Abelmoschi Corolla, but some non-flavonoid components also exist in this herb. In order to clarify the influences of non-flavonoid components on the pharmacokinetics profile of the flavonoid fraction from Abelmoschi Corolla (FFA), an investigation was carried out to compare the pharmacokinetic parameters of seven flavonoid components after administration of FFA and after administration of FFA combined with different non-flavonoid fractions. A selective and sensitive UPLC-MS/MS method was established to determine the plasma concentrations of the seven compounds. Sprague-Dawley rats were allocated to four groups which orally administered FFA, FFA combined with macromolecular fraction (FFA-MF), FFA combined with small molecule fraction (FFA-SF) and FFA combined with MF-SF (FFA-MF-SF) with approximately the same dose of FFA. At different time points, the concentration of rutin (1), hyperoside (2), isoquercitrin (3), hibifolin (4), myricetin (5), quercetin-3'-O-glucose (6), quercetin (7) in rat plasma were determined and main pharmacokinetic parameters including T(1/2), T(max), AUC and C(max) were calculated using the DAS 2.0 software package. The statistical analysis was performed using the Student's t-test with P<0.05 as the level of significance. Flavonoids almost had similar pharmacokinetics profile that were rapidly absorbed, reached the peak concentration at 30-60 min in group A, but the pharmacokinetic profiles and parameters of these flavonoids changed when co-administered with non-flavonoid components. It was found that AUC of five flavonoids but not hibifolin and quercetin in group FFA-SF and group FFA-MF-SF increased (P<0.05) in comparison with group FFA while the tendency was not observed in group FFA-MF. Moreover, seven flavonoids had varying degrees of differences in the pharmacokinetics parameters such as C(max), T(max) and T(1/2) (P<0.05) in group FFA-MF, FFA-SF and FFA-MF-SF by comparison with group FFA. These results indicate that non-flavonoid components could improve the bioavailability and delay the elimination of some flavonoids in rat. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Lithium-ion battery cell-level control using constrained model predictive control and equivalent circuit models

NASA Astrophysics Data System (ADS)

Xavier, Marcelo A.; Trimboli, M. Scott

2015-07-01

This paper introduces a novel application of model predictive control (MPC) to cell-level charging of a lithium-ion battery utilizing an equivalent circuit model of battery dynamics. The approach employs a modified form of the MPC algorithm that caters for direct feed-though signals in order to model near-instantaneous battery ohmic resistance. The implementation utilizes a 2nd-order equivalent circuit discrete-time state-space model based on actual cell parameters; the control methodology is used to compute a fast charging profile that respects input, output, and state constraints. Results show that MPC is well-suited to the dynamics of the battery control problem and further suggest significant performance improvements might be achieved by extending the result to electrochemical models.

The effect of magnetohydrodynamic nano fluid flow through porous cylinder

NASA Astrophysics Data System (ADS)

Widodo, Basuki; Arif, Didik Khusnul; Aryany, Deviana; Asiyah, Nur; Widjajati, Farida Agustini; Kamiran

2017-08-01

This paper concerns about the analysis of the effect of magnetohydrodynamic nano fluid flow through horizontal porous cylinder on steady and incompressible condition. Fluid flow is assumed opposite gravity and induced by magnet field. Porous cylinder is assumed had the same depth of porous and was not absorptive. The First thing to do in this research is to build the model of fluid flow to obtain dimentional governing equations. The dimentional governing equations are consist of continuity equation, momentum equation, and energy equation. Furthermore, the dimensional governing equations are converted to non-dimensional governing equation by using non-dimensional parameters and variables. Then, the non-dimensional governing equations are transformed into similarity equations using stream function and solved using Keller-Box method. The result of numerical solution further is obtained by taking variation of magnetic parameter, Prandtl number, porosity parameter, and volume fraction. The numerical results show that velocity profiles increase and temperature profiles decrease when both of the magnetic and the porosity parameter increase. However, the velocity profiles decrease and the temperature profiles increase when both of the magnetic and the porosity parameter increase.

Estimation of parameter uncertainty for an activated sludge model using Bayesian inference: a comparison with the frequentist method.

PubMed

Zonta, Zivko J; Flotats, Xavier; Magrí, Albert

2014-08-01

The procedure commonly used for the assessment of the parameters included in activated sludge models (ASMs) relies on the estimation of their optimal value within a confidence region (i.e. frequentist inference). Once optimal values are estimated, parameter uncertainty is computed through the covariance matrix. However, alternative approaches based on the consideration of the model parameters as probability distributions (i.e. Bayesian inference), may be of interest. The aim of this work is to apply (and compare) both Bayesian and frequentist inference methods when assessing uncertainty for an ASM-type model, which considers intracellular storage and biomass growth, simultaneously. Practical identifiability was addressed exclusively considering respirometric profiles based on the oxygen uptake rate and with the aid of probabilistic global sensitivity analysis. Parameter uncertainty was thus estimated according to both the Bayesian and frequentist inferential procedures. Results were compared in order to evidence the strengths and weaknesses of both approaches. Since it was demonstrated that Bayesian inference could be reduced to a frequentist approach under particular hypotheses, the former can be considered as a more generalist methodology. Hence, the use of Bayesian inference is encouraged for tackling inferential issues in ASM environments.

Numerical Evaluation of Parameter Correlation in the Hartmann-Tran Line Profile

NASA Astrophysics Data System (ADS)

Adkins, Erin M.; Reed, Zachary; Hodges, Joseph T.

2017-06-01

The partially correlated quadratic, speed-dependent hard-collision profile (pCqSDHCP), for simplicity referred to as the Hartmann-Tran profile (HTP), has been recommended as a generalized lineshape for high resolution spectroscopy. The HTP parameterizes complex collisional effects such as Dicke narrowing, speed dependent narrowing, and correlations between velocity-changing and dephasing collisions, while also simplifying to simpler profiles that are widely used, such as the Voigt profile. As advanced lineshape profiles are adopted by more researchers, it is important to understand the limitations that data quality has on the ability to retrieve physically meaningful parameters using sophisticated lineshapes that are fit to spectra of finite signal-to-noise ratio. In this work, spectra were simulated using the HITRAN Application Programming Interface (HAPI) across a full range of line parameters. Simulated spectra were evaluated to quantify the precision with which fitted lineshape parameters can be determined at a given signal-to-noise ratio, focusing on the numerical correlation between the retrieved Dicke narrowing frequency and the velocity-changing and dephasing collisions correlation parameter. Tran, H., N. Ngo, and J.-M. Hartmann, Journal of Quantitative Spectroscopy and Radiative Transfer 2013. 129: p. 89-100. Tennyson, et al., Pure Appl. Chem. 2014, 86: p. 1931-1943. Kochanov, R.V., et al., Journal of Quantitative Spectroscopy and Radiative Transfer 2016. 177: p. 15-30. Tran, H., N. Ngo, and J.-M. Hartmann, Journal of Quantitative Spectroscopy and Radiative Transfer 2013. 129: p. 199-203.

Clinical state assessment in bipolar patients by means of HRV features obtained with a sensorized T-shirt.

PubMed

Mariani, Sara; Migliorini, Matteo; Tacchino, Giulia; Gentili, Claudio; Bertschy, Gilles; Werner, Sandra; Bianchi, Anna M

2012-01-01

The aim of this study is to identify parameters extracted from the Heart Rate Variability (HRV) signal that correlate to the clinical state in patients affected by bipolar disorder. 25 ECG and activity recordings from 12 patients were obtained by means of a sensorized T-shirt and the clinical state of the subjects was assessed by a psychiatrist. Features in the time and frequency domain were extracted from each signal. HRV features were also used to automatically compute the sleep profile of each subject by means of an Artificial Neural Network, trained on a control group of healthy subjects. From the hypnograms, sleep-specific parameters were computed. All the parameters were compared with those computed on the control group, in order to highlight significant differences in their values during different stages of the pathology. The analysis was performed by grouping the subjects first on the basis of the depression-mania level and then on the basis of the anxiety level.

Numerical treatment for Carreau nanofluid flow over a porous nonlinear stretching surface

NASA Astrophysics Data System (ADS)

Eid, Mohamed R.; Mahny, Kasseb L.; Muhammad, Taseer; Sheikholeslami, Mohsen

2018-03-01

The impact of magnetic field and nanoparticles on the two-phase flow of a generalized non-Newtonian Carreau fluid over permeable non-linearly stretching surface has been analyzed in the existence of all suction/injection and thermal radiation. The governing PDEs with congruous boundary condition are transformed into a system of non-linear ODEs with appropriate boundary conditions by using similarity transformation. It solved numerically by using 4th-5th order Runge-Kutta-Fehlberg method based on shooting technique. The impacts of non-dimensional controlling parameters on velocity, temperature, and nanoparticles volume concentration profiles are scrutinized with aid of graphs. The Nusselt and the Sherwood numbers are studied at the different situations of the governing parameters. The numerical computations are in excellent consent with previously reported studies. It is found that the heat transfer rate is reduced with an increment of thermal radiation parameter and on contrary of the rising of magnetic field. The opposite trend happens in the mass transfer rate.

Device and method for creating Gaussian aberration-corrected electron beams

DOEpatents

McMorran, Benjamin; Linck, Martin

2016-01-19

Electron beam phase gratings have phase profiles that produce a diffracted beam having a Gaussian or other selected intensity profile. Phase profiles can also be selected to correct or compensate electron lens aberrations. Typically, a low diffraction order produces a suitable phase profile, and other orders are discarded.

Numerical Study of Aeroacoustic Sound on Performance of Bladeless Fan

NASA Astrophysics Data System (ADS)

Jafari, Mohammad; Sojoudi, Atta; Hafezisefat, Parinaz

2017-03-01

Aeroacoustic performance of fans is essential due to their widespread application. Therefore, the original aim of this paper is to evaluate the generated noise owing to different geometric parameters. In current study, effect of five geometric parameters was investigated on well performance of a Bladeless fan. Airflow through this fan was analyzed simulating a Bladeless fan within a 2 m×2 m×4 m room. Analysis of the flow field inside the fan and evaluating its performance were obtained by solving conservations of mass and momentum equations for aerodynamic investigations and FW-H noise equations for aeroacoustic analysis. In order to design Bladeless fan Eppler 473 airfoil profile was used as the cross section of this fan. Five distinct parameters, namely height of cross section of the fan, outlet angle of the flow relative to the fan axis, thickness of airflow outlet slit, hydraulic diameter and aspect ratio for circular and quadratic cross sections were considered. Validating acoustic code results, we compared numerical solution of FW-H noise equations for NACA0012 with experimental results. FW-H model was selected to predict the noise generated by the Bladeless fan as the numerical results indicated a good agreement with experimental ones for NACA0012. To validate 3-D numerical results, the experimental results of a round jet showed good agreement with those simulation data. In order to indicate the effect of each mentioned parameter on the fan performance, SPL and OASPL diagrams were illustrated.

Three-dimensional modelling of thin liquid films over spinning disks

NASA Astrophysics Data System (ADS)

Zhao, Kun; Wray, Alex; Yang, Junfeng; Matar, Omar

2016-11-01

In this research the dynamics of a thin film flowing over a rapidly spinning, horizontal disk is considered. A set of non-axisymmetric evolution equations for the film thickness, radial and azimuthal flow rates are derived using a boundary-layer approximation in conjunction with the Karman-Polhausen approximation for the velocity distribution in the film. These highly nonlinear partial differential equations are then solved numerically in order to reveal the formation of two and three-dimensional large-amplitude waves that travel from the disk inlet to its periphery. The spatio-temporal profile of film thickness provides us with visualization of flow structures over the entire disk and by varying system parameters(volumetric flow rate of fluid and rotational speed of disk) different wave patterns can be observed, including spiral, concentric, smooth waves and wave break-up in exceptional conditions. Similar types of waves can be found by experimentalists in literature and CFD simulation and our results show good agreement with both experimental and CFD results. Furthermore, the semi-parabolic velocity profile assumed in our model under the waves is directly compared with CFD data in various flow regimes in order to validate our model. EPSRC UK Programme Grant EP/K003976/1.

Segmentation of vessel-like patterns using mathematical morphology and curvature evaluation.

PubMed

Zana, F; Klein, J C

2001-01-01

This paper presents an algorithm based on mathematical morphology and curvature evaluation for the detection of vessel-like patterns in a noisy environment. Such patterns are very common in medical images. Vessel detection is interesting for the computation of parameters related to blood flow. Its tree-like geometry makes it a usable feature for registration between images that can be of a different nature. In order to define vessel-like patterns, segmentation is performed with respect to a precise model. We define a vessel as a bright pattern, piece-wise connected, and locally linear, mathematical morphology is very well adapted to this description, however other patterns fit such a morphological description. In order to differentiate vessels from analogous background patterns, a cross-curvature evaluation is performed. They are separated out as they have a specific Gaussian-like profile whose curvature varies smoothly along the vessel. The detection algorithm that derives directly from this modeling is based on four steps: (1) noise reduction; (2) linear pattern with Gaussian-like profile improvement; (3) cross-curvature evaluation; (4) linear filtering. We present its theoretical background and illustrate it on real images of various natures, then evaluate its robustness and its accuracy with respect to noise.

Design and Operation of a Two-Color Interferometer to Measure Plasma and Neutral Gas Densities in a Laser-Triggered Spark Gap Switch

NASA Astrophysics Data System (ADS)

Camacho, J. F.; Ruden, E. L.; Domonkos, M. T.; Schmitt-Sody, A.; Lucero, A.

2014-10-01

A Mach-Zehnder imaging interferometer, operating with 1064-nm and 532-nm wavelength beams from a short-pulse laser and a frequency-doubled branch, respectively, has been designed and built to simultaneously measure plasma free electron and neutral gas densities profiles within a laser-triggered spark gap switch with a 5-mm gap. The switch will be triggered by focusing a separate 532-nm or 1064-nm laser pulse along the gap's axis to trigger low-jitter breakdown. Illuminating the gap transverse to this axis, the diagnostic will generate interferograms for each wavelength, which will then be numerically converted to phase-shift maps. These will be used to calculate independent line-integrated free electron and neutral density profiles by exploiting their different frequency dispersion curves. The density profiles themselves, then, will be calculated by Abel inversion. Details of the interferometer's design will be presented along with density data obtained using a variety of fill gasses at various pressures. Other switch parameters will be varied as well in order to characterize more fully the performance of the switch.

Measuring electron temperature in the extended corona

NASA Technical Reports Server (NTRS)

Hassler, Donald M.; Gardner, L. D.; Kohl, John L.

1992-01-01

A technique for measuring electron temperature in the extended corona from the line profile of the electron scattered component of coronal H I Ly alpha produced by Thomson scattering of chromospheric Ly alpha emission is discussed. Because of the high thermal velocity of electrons at coronal temperatures (approximately 6800 km/s at T(sub e) = 1,500,000 K) the effect of nonthermal velocities and solar wind flows on the electron velocity distribution are negligible. However, the low electron mass which is responsible for the high thermal velocity also results in a very wide profile (approximately equal to 50 A). This wide profile, together with an intensity that is three orders of magnitude weaker than the resonantly scattered component of Ly alpha makes the direct measurement of T(sub e) a challenging observational problem. An evaluation of this technique based on simulated measurements is presented and the subsequent instrumental requirements necessary to make a meaningful determination of the electron temperature are discussed. Estimates of uncertainties in the measured electron temperature are related to critical instrument parameters such as grating stray light suppression.

Higher-order paraxial theory of the propagation of ring rippled laser beam in plasma: Relativistic ponderomotive regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Purohit, Gunjan, E-mail: gunjan75@gmail.com; Rawat, Priyanka; Chauhan, Prashant

This article presents higher-order paraxial theory (non-paraxial theory) for the ring ripple formation on an intense Gaussian laser beam and its propagation in plasma, taking into account the relativistic-ponderomotive nonlinearity. The intensity dependent dielectric constant of the plasma has been determined for the main laser beam and ring ripple superimposed on the main laser beam. The dielectric constant of the plasma is modified due to the contribution of the electric field vector of ring ripple. Nonlinear differential equations have been formulated to examine the growth of ring ripple in plasma, self focusing of main laser beam, and ring rippled lasermore » beam in plasma using higher-order paraxial theory. These equations have been solved numerically for different laser intensities and plasma frequencies. The well established experimental laser and plasma parameters are used in numerical calculation. It is observed that the focusing of the laser beams (main and ring rippled) becomes fast in the nonparaxial region by expanding the eikonal and other relevant quantities up to the fourth power of r. The splitted profile of laser beam in the plasma is observed due to uneven focusing/defocusing of the axial and off-axial rays. The growths of ring ripple increase when the laser beam intensity increases. Furthermore, the intensity profile of ring rippled laser beam gets modified due to the contribution of growth rate.« less

Relationship of psychological and physiological parameters during an arctic ski expedition

NASA Astrophysics Data System (ADS)

Bishop, Sheryl L.; Grobler, Lukas C.; SchjØll, Olaf

2001-08-01

Considerable data (primarily physiological) have been collected during expeditions in extreme environments over the last century. Physiological measurements have only recently been examined in association with the emotional or behavioral state of the subject. Establishing this psychophysiological relationship is essential to understanding fully the adaptation of humans to the stresses of extreme environments. This pilot study investigated the simultaneous collection of physiological, psychological and behavioral data from a two-man Greenland expedition in order to model how specific relationships between physiological and psychological adaptation to a polar environment may be identified. The data collected describes changes in adrenal and other hormonal activity and psychological functioning. Levels of cortisol and testosterone were calculated. Factors influencing the plasma profiles of the aforementioned included 24-hour sunlight, high calorific intake of more than 28 000 kJ/day and extreme physical exercise. There was a difference between individual psychological profiles as well as self-report stress and physiological stress.

Analysis of intensity variability in multislice and cone beam computed tomography.

PubMed

Nackaerts, Olivia; Maes, Frederik; Yan, Hua; Couto Souza, Paulo; Pauwels, Ruben; Jacobs, Reinhilde

2011-08-01

The aim of this study was to evaluate the variability of intensity values in cone beam computed tomography (CBCT) imaging compared with multislice computed tomography Hounsfield units (MSCT HU) in order to assess the reliability of density assessments using CBCT images. A quality control phantom was scanned with an MSCT scanner and five CBCT scanners. In one CBCT scanner, the phantom was scanned repeatedly in the same and in different positions. Images were analyzed using registration to a mathematical model. MSCT images were used as a reference. Density profiles of MSCT showed stable HU values, whereas in CBCT imaging the intensity values were variable over the profile. Repositioning of the phantom resulted in large fluctuations in intensity values. The use of intensity values in CBCT images is not reliable, because the values are influenced by device, imaging parameters and positioning. © 2011 John Wiley & Sons A/S.

Dynamical behavior of the random field on the pulsating and snaking solitons in cubic-quintic complex Ginzburg-Landau equation

NASA Astrophysics Data System (ADS)

Bakhtiar, Nurizatul Syarfinas Ahmad; Abdullah, Farah Aini; Hasan, Yahya Abu

2017-08-01

In this paper, we consider the dynamical behaviour of the random field on the pulsating and snaking solitons in a dissipative systems described by the one-dimensional cubic-quintic complex Ginzburg-Landau equation (cqCGLE). The dynamical behaviour of the random filed was simulated by adding a random field to the initial pulse. Then, we solve it numerically by fixing the initial amplitude profile for the pulsating and snaking solitons without losing any generality. In order to create the random field, we choose 0 ≤ ɛ ≤ 1.0. As a result, multiple soliton trains are formed when the random field is applied to a pulse like initial profile for the parameters of the pulsating and snaking solitons. The results also show the effects of varying the random field of the transient energy peaks in pulsating and snaking solitons.

A laser based frequency modulated NL-OSL phenomenon

NASA Astrophysics Data System (ADS)

Mishra, D. R.; Bishnoi, A. S.; Soni, Anuj; Rawat, N. S.; Bhatt, B. C.; Kulkarni, M. S.; Babu, D. A. R.

2015-01-01

The detailed theoretical and experimental approach to novel technique of pulse frequency modulated stimulation (PFMS) method has been described for NL-OSL phenomenon. This method involved pulsed frequency modulation with respect to time for fixed pulse width of 532 nm continuous wave (CW)-laser light. The linearly modulated (LM)-, non-linearly (NL)-stimulation profiles have been generated using fast electromagnetic optical shutter. The PFMS parameters have been determined for present experimental setup. The PFMS based LM-, NL-OSL studies have been carried out on dosimetry grade single crystal α-Al2O3:C. The photo ionization cross section of α-Al2O3:C has been found to be ∼9.97 × 10-19 cm2 for 532 nm laser light using PFMS LM-OSL studies under assumption of first order of kinetic. This method of PFMS is found to be a potential alternative to generate different stimulation profiles using CW-light sources.

[Effect of a change in posture on the diurnal variations of fructosamine concentration in diabetic patients].

PubMed

Willms, B; Schumann, E

1990-01-01

Daily profiles of blood glucose, HbA1c, total protein and fructosamine were measured in 10 diabetic patients and the factor fructosamine x 7/g total protein was calculated. Measurements were done at 4 a.m. to be sure that the patients were sleeping for some time, during the day and the following evening at 11 p.m., when the patients were lying again, so that the influence of orthostasis, the difference between bed rest and walking could be demonstrated. The blood glucose profile was typical whereas the HbA1c concentration was very stable and constant. Total protein and fructosamine increased significantly by orthostasis; the correction of fructosamine by total protein diminished the differences, but did not completely eliminate the effect of orthostasis. However, fructosamine should be corrected by the total protein concentration in order to increase the diagnostic value of the parameter.

Perspective on the reactions between F- and CH3CH2F: the free energy landscape of the E2 and SN2 reaction channels.

PubMed

Ensing, Bernd; Klein, Michael L

2005-05-10

Recently, we computed the 3D free energy surface of the base-induced elimination reaction between F(-) and CH(3)CH(2)F by using a powerful technique within Car-Parrinello molecular dynamics simulation. Here, the set of three order parameters is expanded to six, which allows the study of the competing elimination and substitution reactions simultaneously. The power of the method is exemplified by the exploration of the six-dimensional free energy landscape, sampling, and mapping out the eight stable states as well as the connecting bottlenecks. The free energy profile and barrier along the E2 and S(N)2 reaction channels are refined by using umbrella sampling. The two mechanisms do not share a common "E2C-like" transition state. Comparison with the zero temperature profiles shows a particularly significant entropy contribution to the S(N)2 channel.

The growth of the tearing mode - Boundary and scaling effects

NASA Technical Reports Server (NTRS)

Steinolfson, R. S.; Van Hoven, G.

1983-01-01

A numerical model of resistive magnetic tearing is developed in order to verify and relate the results of the principal approximations used in analytic analyses and to investigate the solutions and their growth-rate scalings over a large range of primary parameters which include parametric values applicable to the solar atmosphere. The computations cover the linear behavior for a variety of boundary conditions, emphasizing effects which differentiate magnetic tearing in astrophysical situations from that in laboratory devices. Eigenfunction profiles for long and short wavelengths are computed and the applicability of the 'constant psi' approximation is investigated. The growth rate is computed for values of the magnetic Reynolds number up to a trillion and of the dimensionless wavelength parameter down to 0.001. The analysis predicts significant effects due to differing values of the magnetic Reynolds number.

Economic method for helical gear flank surface characterisation

NASA Astrophysics Data System (ADS)

Koulin, G.; Reavie, T.; Frazer, R. C.; Shaw, B. A.

2018-03-01

Typically the quality of a gear pair is assessed based on simplified geometric tolerances which do not always correlate with functional performance. In order to identify and quantify functional performance based parameters, further development of the gear measurement approach is required. Methodology for interpolation of the full active helical gear flank surface, from sparse line measurements, is presented. The method seeks to identify the minimum number of line measurements required to sufficiently characterise an active gear flank. In the form ground gear example presented, a single helix and three profile line measurements was considered to be acceptable. The resulting surfaces can be used to simulate the meshing engagement of a gear pair and therefore provide insight into functional performance based parameters. Therefore the assessment of the quality can be based on the predicted performance in the context of an application.

A technique for routinely updating the ITU-R database using radio occultation electron density profiles

NASA Astrophysics Data System (ADS)

Brunini, Claudio; Azpilicueta, Francisco; Nava, Bruno

2013-09-01

Well credited and widely used ionospheric models, such as the International Reference Ionosphere or NeQuick, describe the variation of the electron density with height by means of a piecewise profile tied to the F2-peak parameters: the electron density,, and the height, . Accurate values of these parameters are crucial for retrieving reliable electron density estimations from those models. When direct measurements of these parameters are not available, the models compute the parameters using the so-called ITU-R database, which was established in the early 1960s. This paper presents a technique aimed at routinely updating the ITU-R database using radio occultation electron density profiles derived from GPS measurements gathered from low Earth orbit satellites. Before being used, these radio occultation profiles are validated by fitting to them an electron density model. A re-weighted Least Squares algorithm is used for down-weighting unreliable measurements (occasionally, entire profiles) and to retrieve and values—together with their error estimates—from the profiles. These values are used to monthly update the database, which consists of two sets of ITU-R-like coefficients that could easily be implemented in the IRI or NeQuick models. The technique was tested with radio occultation electron density profiles that are delivered to the community by the COSMIC/FORMOSAT-3 mission team. Tests were performed for solstices and equinoxes seasons in high and low-solar activity conditions. The global mean error of the resulting maps—estimated by the Least Squares technique—is between and elec/m for the F2-peak electron density (which is equivalent to 7 % of the value of the estimated parameter) and from 2.0 to 5.6 km for the height (2 %).

Interaction between a normal shock wave and a turbulent boundary layer at high transonic speeds. Part 1: Pressure distribution

NASA Technical Reports Server (NTRS)

Messiter, A. F.

1979-01-01

Analytical solutions are derived which incorporate additional physical effects as higher order terms for the case when the sonic line is very close to the wall. The functional form used for the undisturbed velocity profile is described to indicate how various parameters will be calculated for later comparison with experiment. The basic solutions for the pressure distribution are derived. Corrections are added for flow along a wall having longitudinal curvature and for flow in a circular pipe, and comparisons with available experimental data are shown.

Effect of rheological parameters on curing rate during NBR injection molding

NASA Astrophysics Data System (ADS)

Kyas, Kamil; Stanek, Michal; Manas, David; Skrobak, Adam

2013-04-01

In this work, non-isothermal injection molding process for NBR rubber mixture considering Isayev-Deng curing kinetic model, generalized Newtonian model with Carreau-WLF viscosity was modeled by using finite element method in order to understand the effect of volume flow rate, index of non-Newtonian behavior and relaxation time on the temperature profile and curing rate. It was found that for specific geometry and processing conditions, increase in relaxation time or in the index of non-Newtonian behavior increases the curing rate due to viscous dissipation taking place at the flow domain walls.

Dark Energy and Key Physical Parameters of Clusters of Galaxies

NASA Astrophysics Data System (ADS)

Chernin, A. D.; Bisnovatyi-Kogan, G. S.

We discuss the physics of clusters of galaxies embedded in the cosmic dark energy background and show that 1) the halo cut-off radius of a cluster like the Virgo cluster is practically, if not exactly, equal to the zero-gravity radius at which the dark matter gravity is balanced by the dark energy antigravity; 2) the halo averaged density is equal to two densities of dark energy; 3) the halo edge (cut-off) density is the dark energy density with a numerical factor of the unity order slightly depending on the halo profile.

Study of component technologies for fuel cell on-site integrated energy system. Volume 2: Appendices

NASA Technical Reports Server (NTRS)

Lee, W. D.; Mathias, S.

1980-01-01

This data base catalogue was compiled in order to facilitate the analysis of various on site integrated energy system with fuel cell power plants. The catalogue is divided into two sections. The first characterizes individual components in terms of their performance profiles as a function of design parameters. The second characterizes total heating and cooling systems in terms of energy output as a function of input and control variables. The integrated fuel cell systems diagrams and the computer analysis of systems are included as well as the cash flows series for baseline systems.

Modelling of the internal dynamics and density in a tens of joules plasma focus device

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marquez, Ariel; Gonzalez, Jose; Tarifeno-Saldivia, Ariel

2012-01-15

Using MHD theory, coupled differential equations were generated using a lumped parameter model to describe the internal behaviour of the pinch compression phase in plasma focus discharges. In order to provide these equations with appropriate initial conditions, the modelling of previous phases was included by describing the plasma sheath as planar shockwaves. The equations were solved numerically, and the results were contrasted against experimental measurements performed on the device PF-50J. The model is able to predict satisfactorily the timing and the radial electron density profile at the maximum compression.

An automatic scaling method for obtaining the trace and parameters from oblique ionogram based on hybrid genetic algorithm

NASA Astrophysics Data System (ADS)

Song, Huan; Hu, Yaogai; Jiang, Chunhua; Zhou, Chen; Zhao, Zhengyu; Zou, Xianjian

2016-12-01

Scaling oblique ionogram plays an important role in obtaining ionospheric structure at the midpoint of oblique sounding path. The paper proposed an automatic scaling method to extract the trace and parameters of oblique ionogram based on hybrid genetic algorithm (HGA). The extracted 10 parameters come from F2 layer and Es layer, such as maximum observation frequency, critical frequency, and virtual height. The method adopts quasi-parabolic (QP) model to describe F2 layer's electron density profile that is used to synthesize trace. And it utilizes secant theorem, Martyn's equivalent path theorem, image processing technology, and echoes' characteristics to determine seven parameters' best fit values, and three parameter's initial values in QP model to set up their searching spaces which are the needed input data of HGA. Then HGA searches the three parameters' best fit values from their searching spaces based on the fitness between the synthesized trace and the real trace. In order to verify the performance of the method, 240 oblique ionograms are scaled and their results are compared with manual scaling results and the inversion results of the corresponding vertical ionograms. The comparison results show that the scaling results are accurate or at least adequate 60-90% of the time.

JavaProtein Dossier: a novel web-based data visualization tool for comprehensive analysis of protein structure

PubMed Central

Neshich, Goran; Rocchia, Walter; Mancini, Adauto L.; Yamagishi, Michel E. B.; Kuser, Paula R.; Fileto, Renato; Baudet, Christian; Pinto, Ivan P.; Montagner, Arnaldo J.; Palandrani, Juliana F.; Krauchenco, Joao N.; Torres, Renato C.; Souza, Savio; Togawa, Roberto C.; Higa, Roberto H.

2004-01-01

JavaProtein Dossier (JPD) is a new concept, database and visualization tool providing one of the largest collections of the physicochemical parameters describing proteins' structure, stability, function and interaction with other macromolecules. By collecting as many descriptors/parameters as possible within a single database, we can achieve a better use of the available data and information. Furthermore, data grouping allows us to generate different parameters with the potential to provide new insights into the sequence–structure–function relationship. In JPD, residue selection can be performed according to multiple criteria. JPD can simultaneously display and analyze all the physicochemical parameters of any pair of structures, using precalculated structural alignments, allowing direct parameter comparison at corresponding amino acid positions among homologous structures. In order to focus on the physicochemical (and consequently pharmacological) profile of proteins, visualization tools (showing the structure and structural parameters) also had to be optimized. Our response to this challenge was the use of Java technology with its exceptional level of interactivity. JPD is freely accessible (within the Gold Sting Suite) at http://sms.cbi.cnptia.embrapa.br, http://mirrors.rcsb.org/SMS, http://trantor.bioc.columbia.edu/SMS and http://www.es.embnet.org/SMS/ (Option: JavaProtein Dossier). PMID:15215458

Variations of the ionospheric parameters and vertical electron density distribution at the northern edge of the EIA from 2010 to 2015 along 95°E and comparison with the IRI-2012

NASA Astrophysics Data System (ADS)

Kalita, Bitap Raj; Bhuyan, Pradip Kumar

2017-07-01

The vertical electron density profiles over Dibrugarh (27.5°N, 95°E, 43° dip) a low mid latitude station normally located at the northern edge of the EIA for the period of July 2010 till October 2015 are constructed from the measured bottom side profiles and ionosonde-GPS TEC assisted Topside Sounder Model (TSM) topside profiles. The bottom side density profiles are obtained by using POLAN on the manually scaled ionograms. The topside is constructed by the modified ionosonde assisted TSM model (TaP-TSM assisted by POLAN) which is integrated with POLAN for the first time. The reconstructed vertical profile is compared with the IRI predicted density profile and the electron density profile obtained from the COSMIC/FORMOSAT radio occultation measurements over Dibrugarh. The bottom side density profiles are fitted to the IRI bottom side function to obtain best-fit bottom side thickness parameter B0 and shape parameter B1. The temporal and solar activity variation of the B-parameters over Dibrugarh are investigated and compared to those predicted by IRI-2012 model with ABT-2009 option. The bottom side thickness parameter B0 predicted by the IRI model is found to be similar to the B0 measured over Dibrugarh in the night time and the forenoon hours. Differences are observed in the early morning and the afternoon period. The IRI doesn't reproduce the morning collapse of B0 and overestimates the B0 over Dibrugarh in the afternoon period, particularly in summer and equinox. The IRI model predictions are closest to the measured B0 in the winter of low solar activity. The B0 over Dibrugarh is found to increase by about 15% with solar activity during the period of study encompassing almost the first half of solar cycle 24 but solar activity effect was not observed in the B1 parameter. The topside profile obtained from TaP profiler is thicker than the IRI topside in equinox from afternoon to sunrise period but is similar to the IRI in summer daytime. The differences in the bottom side may be attributed to the non-inclusion of ground measurements from 90°E to 100°E longitude in the ABT-2009 model while differences in the topside could be due the non-uniform longitudinal distribution of topside sounder profiles data and the stronger fountain effect in this longitude.

A retrieval algorithm of hydrometer profile for submillimeter-wave radiometer

NASA Astrophysics Data System (ADS)

Liu, Yuli; Buehler, Stefan; Liu, Heguang

2017-04-01

Vertical profiles of particle microphysics perform vital functions for the estimation of climatic feedback. This paper proposes a new algorithm to retrieve the profile of the parameters of the hydrometeor(i.e., ice, snow, rain, liquid cloud, graupel) based on passive submillimeter-wave measurements. These parameters include water content and particle size. The first part of the algorithm builds the database and retrieves the integrated quantities. Database is built up by Atmospheric Radiative Transfer Simulator(ARTS), which uses atmosphere data to simulate the corresponding brightness temperature. Neural network, trained by the precalculated database, is developed to retrieve the water path for each type of particles. The second part of the algorithm analyses the statistical relationship between water path and vertical parameters profiles. Based on the strong dependence existing between vertical layers in the profiles, Principal Component Analysis(PCA) technique is applied. The third part of the algorithm uses the forward model explicitly to retrieve the hydrometeor profiles. Cost function is calculated in each iteration, and Differential Evolution(DE) algorithm is used to adjust the parameter values during the evolutionary process. The performance of this algorithm is planning to be verified for both simulation database and measurement data, by retrieving profiles in comparison with the initial one. Results show that this algorithm has the ability to retrieve the hydrometeor profiles efficiently. The combination of ARTS and optimization algorithm can get much better results than the commonly used database approach. Meanwhile, the concept that ARTS can be used explicitly in the retrieval process shows great potential in providing solution to other retrieval problems.

Inorganic material profiling using Arn+ cluster: Can we achieve high quality profiles?

NASA Astrophysics Data System (ADS)

Conard, T.; Fleischmann, C.; Havelund, R.; Franquet, A.; Poleunis, C.; Delcorte, A.; Vandervorst, W.

2018-06-01

Retrieving molecular information by sputtering of organic systems has been concretized in the last years due to the introduction of sputtering by large gas clusters which drastically eliminated the compound degradation during the analysis and has led to strong improvements in depth resolution. Rapidly however, a limitation was observed for heterogeneous systems where inorganic layers or structures needed to be profiled concurrently. As opposed to organic material, erosion of the inorganic layer appears very difficult and prone to many artefacts. To shed some light on these problems we investigated a simple system consisting of aluminum delta layer(s) buried in a silicon matrix in order to define the most favorable beam conditions for practical analysis. We show that counterintuitive to the small energy/atom used and unlike monoatomic ion sputtering, the information depth obtained with large cluster ions is typically very large (∼10 nm) and that this can be caused both by a large roughness development at early stages of the sputtering process and by a large mixing zone. As a consequence, a large deformation of the Al intensity profile is observed. Using sample rotation during profiling significantly improves the depth resolution while sample temperature has no significant effect. The determining parameter for high depth resolution still remains the total energy of the cluster instead of the energy per atom in the cluster.

Dry etching of chrome for photomasks for 100-nm technology using chemically amplified resist

NASA Astrophysics Data System (ADS)

Mueller, Mark; Komarov, Serguie; Baik, Ki-Ho

2002-07-01

Photo mask etching for the 100nm technology node places new requirements on dry etching processes. As the minimum-size features on the mask, such as assist bars and optical proximity correction (OPC) patterns, shrink down to 100nm, it is necessary to produce etch CD biases of below 20nm in order to reproduce minimum resist features into chrome with good pattern fidelity. In addition, vertical profiles are necessary. In previous generations of photomask technology, footing and sidewall profile slope were tolerated, since this dry etch profile was an improvement from wet etching. However, as feature sizes shrink, it is extremely important to select etch processes which do not generate a foot, because this will affect etch linearity and also limit the smallest etched feature size. Chemically amplified resist (CAR) from TOK is patterned with a 50keV MEBES eXara e-beam writer, allowing for patterning of small features with vertical resist profiles. This resist is developed for raster scan 50 kV e-beam systems. It has high contrast, good coating characteristics, good dry etch selectivity, and high environmental stability. Chrome etch process development has been performed using Design of Experiments to optimize parameters such as sidewall profile, etch CD bias, etch CD linearity for varying sizes of line/space patterns, etch CD linearity for varying sizes of isolated lines and spaces, loading effects, and application to contact etching.

Determination of the effect of lift characteristics on dynamic performance profiles during manual materials handling tasks.

PubMed

Khalaf, K A; Parnianpour, M; Sparto, P J; Barin, K

1999-01-01

In any quantitative gait or occupational biomechanics investigation, the quantification of the different kinematic, kinetic, and electromyographic parameters is essential towards assessment of functional capacity and development of a biomechanical profile of the task demands. In the current study, the authors presented a methodology for using inferential statistics to evaluate the effect of lift characteristics on phase-dependent and phase-independent variability in performance. Using a database of kinematic and kinetic profiles obtained from a manual lifting study, the phase-dependent effects of lift characteristics: box mass (load), mode (technique of lift), and speed (frequency of lift) were investigated through the use of analysis of variance (ANOVA) techniques, which recognize the vectorial constitution of the profiles. In addition, the Karhunen-Loeve Expansion (KLE) feature extraction method was used for representing the lifting patterns of measured joint angular position, velocity, acceleration, and net muscular torque profiles obtained from a 2-D biomechanical lifting model in order to study the phase-independent effects. In comparison to traditional descriptive statistical analyses currently used in various occupational biomechanics experimental investigations, this method allows the significant information content of the time varying signal to be captured, enhancing the sensitivity of subsequent hypothesis testing procedures. The application of this technique to MMH investigations allows identification of the lift characteristics that dominate the variability of task demands, hence aiding in the design and assessment of ergonomic solutions.

Absorption characteristics of epidural levobupivacaine with adrenaline and clonidine in children.

PubMed

Chalkiadis, George A; Abdullah, Farah; Bjorksten, Andrew R; Clarke, Alexander; Cortinez, Luis I; Udayasiri, Sonal; Anderson, Brian J

2013-01-01

To determine if the addition of adrenaline, clonidine, or their combination altered the pharmacokinetic profile of levobupivacaine administered via the caudal epidural route in children. Children aged <18 years old scheduled to undergo sub-umbilical surgery were administered caudal levobupivacaine plain 2.5 mg · ml(-1) or with adjuvants adrenaline 5 mcg · ml(-1) or clonidine 2 mcg · ml(-1) or their combination. Covariate analysis included weight and postnatal age (PNA). Time-concentration profile analysis was undertaken using nonlinear mixed effects models. A one-compartment linear disposition model with first-order input and first-order elimination was used to describe the data. The effect of either clonidine or adrenaline on absorption was investigated using a scaling parameter (Fabs(CLON), Fabs(ADR)) applied to the absorption half-life (Tabs). There were 240 children (median weight 11.0, range 1.9-56.1 kg; median postnatal age 16.7, range 0.6-167.6 months). Absorption of levobupivacaine was faster when mixed with clonidine (Fabs(CLON) 0.60; 95%CI 0.44, 0.83) but slower when mixed with adrenaline (Fabs(ADR) 2.12; 95%CI 1.45, 3.08). The addition of adrenaline to levobupivacaine resulted in a bifid absorption pattern. While initial absorption was unchanged (Tabs 0.15 h 95%CI 0.12, 0.18 h), there was a late absorption peak characterized by a Tabs(LATE) 2.34 h (95%CI 1.44, 4.97 h). The additional use of clonidine with adrenaline had minimal effect on the bifid absorption profile observed with adrenaline alone. Neither clonidine nor adrenaline had any effect on clearance. The population parameter estimate for volume of distribution was 157 l 70 kg(-1). Clearance was 6.5 l · h(-1) 70 kg(-1) at 1-month PNA and increased with a maturation half-time of 1.6 months to reach 90% of the mature value (18.5 l · h(-1) 70 kg(-1)) by 5 months PNA. The addition of adrenaline decreases the rate of levobupivacaine systemic absorption, reducing peak concentration by half. Levobupivacaine concentrations with adrenaline adjuvant were reduced compared to plain levobupivacaine for up to 3.5 hours. Clonidine as an adjuvant results in faster systemic absorption of levobupivacaine and similar concentration time profile to levobupivacaine alone. Adding adrenaline with clonidine does not alter the concentration profile observed with adrenaline alone. © 2012 Blackwell Publishing Ltd.

SASS Applied to Optimum Work Roll Profile Selection in the Hot Rolling of Wide Steel

NASA Astrophysics Data System (ADS)

Nolle, Lars

The quality of steel strip produced in a wide strip rolling mill depends heavily on the careful selection of initial ground work roll profiles for each of the mill stands in the finishing train. In the past, these profiles were determined by human experts, based on their knowledge and experience. In previous work, the profiles were successfully optimised using a self-organising migration algorithm (SOMA). In this research, SASS, a novel heuristic optimisation algorithm that has only one control parameter, has been used to find the optimum profiles for a simulated rolling mill. The resulting strip quality produced using the profiles found by SASS is compared with results from previous work and the quality produced using the original profile specifications. The best set of profiles found by SASS clearly outperformed the original set and performed equally well as SOMA without the need of finding a suitable set of control parameters.

Protective effect of ascorbic acid on netilmicin-induced lipid profile and peroxidation parameters in rabbit blood plasma.

PubMed

Devbhuti, Pritesh; Sikdar, Debasis; Saha, Achintya; Sengupta, Chandana

2011-01-01

A drug may cause alteration in blood-lipid profile and induce lipid peroxidation phenomena on administration in the body. Antioxidant may play beneficial role to control the negative alteration in lipid profile and lipid peroxidation. In view of this context, the present in vivo study was carried out to evaluate the role of ascorbic acid as antioxidant on netilmicin-induced alteration of blood lipid profile and peroxidation parameters. Rabbits were used as experimental animals and blood was collected to estimate blood-lipid profiles, such as total cholesterol (TCh), high density lipoprotein cholesterol (HDL-Ch), low density lipoprotein cholesterol (LDL-Ch), very low density lipoprotein cholesterol (VLDL-Ch), triglycerides (Tg), phospholipids (PL), and total lipids (TL), as well as peroxidation parameters, such as malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), reduced glutathione (GSH) and nitric oxide (NO). The results revealed that netilmicin caused significant enhancement of MDA, HNE, TCh, LDL-Ch, VLDL-Ch, Tg levels and reduction in GSH, NO, HDL-Ch, PL, TL levels. On co-administration, ascorbic acid was found to be effective in reducing netilmicin-induced negative alterations of the above parameters.

As-Built design specification for PARPLT. [program to produce scatter plots of crop greenness profile parameters

NASA Technical Reports Server (NTRS)

Tompkins, M. A.; Cheng, D. E. (Principal Investigator)

1981-01-01

The design and implementation of the PARPLT program are described. The program produces scatter plots of the greenness profile derived parameters alpha, beta, and t sub o computed by the CLASFYG program (alpha being the approximate greenness rise time; beta, the greenness decay time; and t sub o, the spectral crop emergence date). Statistical information concerning the parameters is also computed.

Pepsi-SAXS: an adaptive method for rapid and accurate computation of small-angle X-ray scattering profiles.

PubMed

Grudinin, Sergei; Garkavenko, Maria; Kazennov, Andrei

2017-05-01

A new method called Pepsi-SAXS is presented that calculates small-angle X-ray scattering profiles from atomistic models. The method is based on the multipole expansion scheme and is significantly faster compared with other tested methods. In particular, using the Nyquist-Shannon-Kotelnikov sampling theorem, the multipole expansion order is adapted to the size of the model and the resolution of the experimental data. It is argued that by using the adaptive expansion order, this method has the same quadratic dependence on the number of atoms in the model as the Debye-based approach, but with a much smaller prefactor in the computational complexity. The method has been systematically validated on a large set of over 50 models collected from the BioIsis and SASBDB databases. Using a laptop, it was demonstrated that Pepsi-SAXS is about seven, 29 and 36 times faster compared with CRYSOL, FoXS and the three-dimensional Zernike method in SAStbx, respectively, when tested on data from the BioIsis database, and is about five, 21 and 25 times faster compared with CRYSOL, FoXS and SAStbx, respectively, when tested on data from SASBDB. On average, Pepsi-SAXS demonstrates comparable accuracy in terms of χ 2 to CRYSOL and FoXS when tested on BioIsis and SASBDB profiles. Together with a small allowed variation of adjustable parameters, this demonstrates the effectiveness of the method. Pepsi-SAXS is available at http://team.inria.fr/nano-d/software/pepsi-saxs.

Feature Profile Evolution of SiO2 Trenches In Fluorocarbon Plasmas

NASA Technical Reports Server (NTRS)

Hwang, Helen; Govindan, T. R.; Meyyappan, M.; Arunachalam, Valli; Rauf, Shahid; Coronell, Dan; Carroll, Carol W. (Technical Monitor)

1999-01-01

Etching of silicon microstructures for semiconductor manufacturing in chlorine plasmas has been well characterized. The etching proceeds in a two-part process, where the chlorine neutrals passivate the Si surface and then the ions etch away SiClx. However, etching in more complicated gas mixtures and materials, such as etching of SiO2 in Ar/C4F8, requires knowledge of the ion and neutral distribution functions as a function of angle and velocity, in addition to modeling the gas surface reactions. In order to address these needs, we have developed and integrated a suite of models to simulate the etching process from the plasma reactor level to the feature profile evolution level. This arrangement allows for a better understanding, control, and prediction of the influence of equipment level process parameters on feature profile evolution. We are currently using the HPEM (Hybrid Plasma Equipment Model) and PCMCM (Plasma Chemistry Monte Carlo Model) to generate plasma properties and ion and neutral distribution functions for argon/fluorocarbon discharges in a GEC Reference Cell. These quantities are then input to the feature scale model, Simulation of Profile Evolution by Level Sets (SPELS). A surface chemistry model is used to determine the interaction of the incoming species with the substrate material and simulate the evolution of the trench profile. The impact of change of gas pressure and inductive power on the relative flux of CFx and F to the wafer, the etch and polymerization rates, and feature profiles will be examined. Comparisons to experimental profiles will also be presented.

Method and system for SCR optimization

DOEpatents

Lefebvre, Wesley Curt [Boston, MA; Kohn, Daniel W [Cambridge, MA

2009-03-10

Methods and systems are provided for controlling SCR performance in a boiler. The boiler includes one or more generally cross sectional areas. Each cross sectional area can be characterized by one or more profiles of one or more conditions affecting SCR performance and be associated with one or more adjustable desired profiles of the one or more conditions during the operation of the boiler. The performance of the boiler can be characterized by boiler performance parameters. A system in accordance with one or more embodiments of the invention can include a controller input for receiving a performance goal for the boiler corresponding to at least one of the boiler performance parameters and for receiving data values corresponding to boiler control variables and to the boiler performance parameters. The boiler control variables include one or more current profiles of the one or more conditions. The system also includes a system model that relates one or more profiles of the one or more conditions in the boiler to the boiler performance parameters. The system also includes an indirect controller that determines one or more desired profiles of the one or more conditions to satisfy the performance goal for the boiler. The indirect controller uses the system model, the received data values and the received performance goal to determine the one or more desired profiles of the one or more conditions. The system model also includes a controller output that outputs the one or more desired profiles of the one or more conditions.

Edge Modeling by Two Blur Parameters in Varying Contrasts.

PubMed

Seo, Suyoung

2018-06-01

This paper presents a method of modeling edge profiles with two blur parameters, and estimating and predicting those edge parameters with varying brightness combinations and camera-to-object distances (COD). First, the validity of the edge model is proven mathematically. Then, it is proven experimentally with edges from a set of images captured for specifically designed target sheets and with edges from natural images. Estimation of the two blur parameters for each observed edge profile is performed with a brute-force method to find parameters that produce global minimum errors. Then, using the estimated blur parameters, actual blur parameters of edges with arbitrary brightness combinations are predicted using a surface interpolation method (i.e., kriging). The predicted surfaces show that the two blur parameters of the proposed edge model depend on both dark-side edge brightness and light-side edge brightness following a certain global trend. This is similar across varying CODs. The proposed edge model is compared with a one-blur parameter edge model using experiments of the root mean squared error for fitting the edge models to each observed edge profile. The comparison results suggest that the proposed edge model has superiority over the one-blur parameter edge model in most cases where edges have varying brightness combinations.

A multi-approach geophysical estimation of soil dynamic properties in settlements: a case study in Güzelbahce-İzmir (Western Anatolia)

NASA Astrophysics Data System (ADS)

Akgün, Mustafa; Gönenç, Tolga; Tunçel, Aykut; Pamukçu, Oya

2013-08-01

An earthquake is a natural disaster which cannot be predicted beforehand. The economic losses and casualties induced by earthquakes badly influence human life. In order to reduce these negative effects, buildings and structures should be designed to be earthquake resistant. In the design stage of earthquake-resistant structures, models of soil under dynamic conditions are used. The parameters that are required to account for soil dynamic models are shear wave velocity (Vs) values, stiffness, thickness, the number of layers, attenuation, rigidity and the depth to bedrock. These parameters are used to calculate an empirical transfer function, the bearing capacity of the soil and liquefaction. Within this context, these soil dynamic parameters should be obtained with the help of geophysical methods in situ, in the İzmir-Güzelbahçe region and its surrounds. The İzmir-Güzelbahçe region and its surrounds are located at the intersection point of two major faults (the İzmir fault and the Seferihisar fault). For this reason, soil dynamic parameters are variable in the lateral and vertical directions. These changes affect the soil Vs profiles. To identify the shear wave velocity (Vs) profile, common mid-point cross-correlation analysis of multi-channel surface-wave data (CMPCC MASW method), microtremor and microgravity methods can be used in common. As a result, when these three methods were evaluated together, it was concluded that the aforementioned region shows sudden lateral structure changes. Relying on these changes, the dynamic analyses that would be carried out to determine soil behavior at a possible earthquake site should be taken into consideration.

Evaluation of parameters of color profile models of LCD and LED screens

NASA Astrophysics Data System (ADS)

Zharinov, I. O.; Zharinov, O. O.

2017-12-01

The purpose of the research relates to the problem of parametric identification of the color profile model of LCD (liquid crystal display) and LED (light emitting diode) screens. The color profile model of a screen is based on the Grassmann’s Law of additive color mixture. Mathematically the problem is to evaluate unknown parameters (numerical coefficients) of the matrix transformation between different color spaces. Several methods of evaluation of these screen profile coefficients were developed. These methods are based either on processing of some colorimetric measurements or on processing of technical documentation data.

Enhancing analog seismic data resolution using the A/D converter: Examples of Sicilia Channel and Marmara Sea data set

NASA Astrophysics Data System (ADS)

Alp, H.

2015-12-01

We present here two data set composed of about 20 multichannel seismic data profiles, for a total of 1102 km of data acquired in the Sicilia Channel in Italy and Marmara Sea in Turkey. The data set of Multichannel seismic reflection profiles and well information acquired for commercial purpose by oil companies in the 1970's and 1980's. All profiles in Sicilia Channel, which are available on .pdf files were downloaded from VIDEPI website. Other profiles in Marmara Sea were taken from Turkish Petroleum Corporation. The first step was to convert the graphic files SEG-Y format files, using SeisTrans® software. Due to the great inhomogeneity of the various seismic lines, which have been recorded from different companies with different acquisition parameters, it has been necessary a great job of homogenization and noise reduction through the use of adequate band-pass filters. Then, for each reconstructed seismic line, SEG-Y header editing was necessary in order to assign the CDP (common-depth-points) and the SP (shot points) to the corresponding geographic coordinates. The SEG-Y files so created were uploaded and archived into a project using the Kingdom Suite® seismic package. To perform the calibration of seismic data with the stratigraphic wells, the classic problem is to identify on seismic profiles the reflections corresponding to the lithological variations identified in the wells. This is because the vertical scale of the seismic data is expressed in time, while that of the wells is expressed in meters. The main unknown is then the sound velocity within the different lithologies. In order to better correlate real data reflections with the corresponding stratigraphic discontinuities, synthetic seismogram have been created from the reflectivity series obtained through acoustic impedance calculations. They represent an example of forward modeling to match as closely as possible the real seismic data.

The electrical MHD and Hall current impact on micropolar nanofluid flow between rotating parallel plates

NASA Astrophysics Data System (ADS)

Shah, Zahir; Islam, Saeed; Gul, Taza; Bonyah, Ebenezer; Altaf Khan, Muhammad

2018-06-01

The current research aims to examine the combined effect of magnetic and electric field on micropolar nanofluid between two parallel plates in a rotating system. The nanofluid flow between two parallel plates is taken under the influence of Hall current. The flow of micropolar nanofluid has been assumed in steady state. The rudimentary governing equations have been changed to a set of differential nonlinear and coupled equations using suitable similarity variables. An optimal approach has been used to acquire the solution of the modelled problems. The convergence of the method has been shown numerically. The impact of the Skin friction on velocity profile, Nusslet number on temperature profile and Sherwood number on concentration profile have been studied. The influences of the Hall currents, rotation, Brownian motion and thermophoresis analysis of micropolar nanofluid have been mainly focused in this work. Moreover, for comprehension the physical presentation of the embedded parameters that is, coupling parameter N1 , viscosity parameter Re , spin gradient viscosity parameter N2 , rotating parameter Kr , Micropolar fluid constant N3 , magnetic parameter M , Prandtl number Pr , Thermophoretic parameter Nt , Brownian motion parameter Nb , and Schmidt number Sc have been plotted and deliberated graphically.

Body composition indices and predicted cardiovascular disease risk profile among urban dwellers in Malaysia.

PubMed

Su, Tin Tin; Amiri, Mohammadreza; Mohd Hairi, Farizah; Thangiah, Nithiah; Dahlui, Maznah; Majid, Hazreen Abdul

2015-01-01

This study aims to compare various body composition indices and their association with a predicted cardiovascular disease (CVD) risk profile in an urban population in Kuala Lumpur, Malaysia. A cross-sectional survey was conducted in metropolitan Kuala Lumpur, Malaysia, in 2012. Households were selected using a simple random-sampling method, and adult members were invited for medical screening. The Framingham Risk Scoring algorithm was used to predict CVD risk, which was then analyzed in association with body composition measurements, including waist circumference, waist-hip ratio, waist-height ratio, body fat percentage, and body mass index. Altogether, 882 individuals were included in our analyses. Indices that included waist-related measurements had the strongest association with CVD risk in both genders. After adjusting for demographic and socioeconomic variables, waist-related measurements retained the strongest correlations with predicted CVD risk in males. However, body mass index, waist-height ratio, and waist circumference had the strongest correlation with CVD risk in females. The waist-related indicators of abdominal obesity are important components of CVD risk profiles. As waist-related parameters can quickly and easily be measured, they should be routinely obtained in primary care settings and population health screens in order to assess future CVD risk profiles and design appropriate interventions.

Body Composition Indices and Predicted Cardiovascular Disease Risk Profile among Urban Dwellers in Malaysia

PubMed Central

Su, Tin Tin; Amiri, Mohammadreza; Mohd Hairi, Farizah; Thangiah, Nithiah; Dahlui, Maznah; Majid, Hazreen Abdul

2015-01-01

Objectives. This study aims to compare various body composition indices and their association with a predicted cardiovascular disease (CVD) risk profile in an urban population in Kuala Lumpur, Malaysia. Methods. A cross-sectional survey was conducted in metropolitan Kuala Lumpur, Malaysia, in 2012. Households were selected using a simple random-sampling method, and adult members were invited for medical screening. The Framingham Risk Scoring algorithm was used to predict CVD risk, which was then analyzed in association with body composition measurements, including waist circumference, waist-hip ratio, waist-height ratio, body fat percentage, and body mass index. Results. Altogether, 882 individuals were included in our analyses. Indices that included waist-related measurements had the strongest association with CVD risk in both genders. After adjusting for demographic and socioeconomic variables, waist-related measurements retained the strongest correlations with predicted CVD risk in males. However, body mass index, waist-height ratio, and waist circumference had the strongest correlation with CVD risk in females. Conclusions. The waist-related indicators of abdominal obesity are important components of CVD risk profiles. As waist-related parameters can quickly and easily be measured, they should be routinely obtained in primary care settings and population health screens in order to assess future CVD risk profiles and design appropriate interventions. PMID:25710002

A comparative study of surface waves inversion techniques at strong motion recording sites in Greece

USGS Publications Warehouse

Panagiotis C. Pelekis,; Savvaidis, Alexandros; Kayen, Robert E.; Vlachakis, Vasileios S.; Athanasopoulos, George A.

2015-01-01

Surface wave method was used for the estimation of Vs vs depth profile at 10 strong motion stations in Greece. The dispersion data were obtained by SASW method, utilizing a pair of electromechanical harmonic-wave source (shakers) or a random source (drop weight). In this study, three inversion techniques were used a) a recently proposed Simplified Inversion Method (SIM), b) an inversion technique based on a neighborhood algorithm (NA) which allows the incorporation of a priori information regarding the subsurface structure parameters, and c) Occam's inversion algorithm. For each site constant value of Poisson's ratio was assumed (ν=0.4) since the objective of the current study is the comparison of the three inversion schemes regardless the uncertainties resulting due to the lack of geotechnical data. A penalty function was introduced to quantify the deviations of the derived Vs profiles. The Vs models are compared as of Vs(z), Vs30 and EC8 soil category, in order to show the insignificance of the existing variations. The comparison results showed that the average variation of SIM profiles is 9% and 4.9% comparing with NA and Occam's profiles respectively whilst the average difference of Vs30 values obtained from SIM is 7.4% and 5.0% compared with NA and Occam's.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Triana, S. A.; Moravveji, E.; Pápics, P. I.

The internal angular momentum distribution of a star is the key to determining its evolution. Fortunately, stellar internal rotation can be probed through studies of rotationally split nonradial oscillation modes. In particular, the detection of nonradial gravity modes (g modes) in massive young stars has recently become feasible thanks to the Kepler space mission. Our goal is to derive the internal rotation profile of the Kepler B8V star KIC 10526294 through asteroseismology. We interpret the observed rotational splittings of its dipole g modes using four different approaches based on the best seismic models of the star and their rotational kernels.more » We show that these kernels can resolve differential rotation within the radiative envelope if a smooth rotational profile is assumed and if the observational errors are small. Based on Kepler data, we find that the rotation rate near the core-envelope boundary is well constrained to 163 ± 89 nHz. The seismic data are consistent with rigid rotation but a profile with counter-rotation within the envelope has a statistical advantage over constant rotation. Our study should be repeated for other massive stars with a variety of stellar parameters in order to determine the physical conditions that control the internal rotation profile of young massive stars, with the aim of improving the input physics of their models.« less

Depth resolution and preferential sputtering in depth profiling of sharp interfaces

NASA Astrophysics Data System (ADS)

Hofmann, S.; Han, Y. S.; Wang, J. Y.

2017-07-01

The influence of preferential sputtering on depth resolution of sputter depth profiles is studied for different sputtering rates of the two components at an A/B interface. Surface concentration and intensity depth profiles on both the sputtering time scale (as measured) and the depth scale are obtained by calculations with an extended Mixing-Roughness-Information depth (MRI)-model. The results show a clear difference for the two extreme cases (a) preponderant roughness and (b) preponderant atomic mixing. In case (a), the interface width on the time scale (Δt(16-84%)) increases with preferential sputtering if the faster sputtering component is on top of the slower sputtering component, but the true resolution on the depth scale (Δz(16-84%)) stays constant. In case (b), the interface width on the time scale stays constant but the true resolution on the depth scale varies with preferential sputtering. For similar order of magnitude of the atomic mixing and the roughness parameters, a transition state between the two extremes is obtained. While the normalized intensity profile of SIMS represents that of the surface concentration, an additional broadening effect is encountered in XPS or AES by the influence of the mean electron escape depth which may even cause an additional matrix effect at the interface.

Determination of the vinyl fluoride line intensities by TDL spectroscopy: the object oriented approach of Visual Line Shape Fitting Program to line profile analysis

NASA Astrophysics Data System (ADS)

Tasinato, Nicola; Pietropolli Charmet, Andrea; Stoppa, Paolo; Giorgianni, Santi

2010-03-01

In this work the self-broadening coefficients and the integrated line intensities for a number of ro-vibrational transitions of vinyl fluoride have been determined for the first time by means of TDL spectroscopy. The spectra recorded in the atmospheric window around 8.7 µm appear very crowded with a density of about 90 lines per cm-1. In order to fit these spectral features a new fitting software has been implemented. The program, which is designed for laser spectroscopy, can fit many lines simultaneously on the basis of different theoretical profiles (Doppler, Lorentz, Voigt, Galatry and Nelkin-Ghatak). Details of the object oriented implementation of the application are given. The reliability of the program is demonstrated by determining the line parameters of some ro-vibrational lines of sulphur dioxide in the ν1 band region around 9 µm. Then the software is used for the line profile analysis of vinyl fluoride. The experimental line shapes show deviations from the Voigt profile, which can be well modelled by using a Dicke narrowed line shape function. This leads to the determination of the self-narrowing coefficient within the framework of the strong collision model.

Statistical inference methods for sparse biological time series data.

PubMed

Ndukum, Juliet; Fonseca, Luís L; Santos, Helena; Voit, Eberhard O; Datta, Susmita

2011-04-25

Comparing metabolic profiles under different biological perturbations has become a powerful approach to investigating the functioning of cells. The profiles can be taken as single snapshots of a system, but more information is gained if they are measured longitudinally over time. The results are short time series consisting of relatively sparse data that cannot be analyzed effectively with standard time series techniques, such as autocorrelation and frequency domain methods. In this work, we study longitudinal time series profiles of glucose consumption in the yeast Saccharomyces cerevisiae under different temperatures and preconditioning regimens, which we obtained with methods of in vivo nuclear magnetic resonance (NMR) spectroscopy. For the statistical analysis we first fit several nonlinear mixed effect regression models to the longitudinal profiles and then used an ANOVA likelihood ratio method in order to test for significant differences between the profiles. The proposed methods are capable of distinguishing metabolic time trends resulting from different treatments and associate significance levels to these differences. Among several nonlinear mixed-effects regression models tested, a three-parameter logistic function represents the data with highest accuracy. ANOVA and likelihood ratio tests suggest that there are significant differences between the glucose consumption rate profiles for cells that had been--or had not been--preconditioned by heat during growth. Furthermore, pair-wise t-tests reveal significant differences in the longitudinal profiles for glucose consumption rates between optimal conditions and heat stress, optimal and recovery conditions, and heat stress and recovery conditions (p-values <0.0001). We have developed a nonlinear mixed effects model that is appropriate for the analysis of sparse metabolic and physiological time profiles. The model permits sound statistical inference procedures, based on ANOVA likelihood ratio tests, for testing the significance of differences between short time course data under different biological perturbations.

On the Use of Topside RO-Derived Electron Density for Model Validation

NASA Astrophysics Data System (ADS)

Shaikh, M. M.; Nava, B.; Haralambous, H.

2018-05-01

In this work, the standard Abel inversion has been exploited as a powerful observation tool, which may be helpful to model the topside of the ionosphere and therefore to validate ionospheric models. A thorough investigation on the behavior of radio occultation (RO)-derived topside electron density (Ne(h))-profiles has therefore been performed with the main purpose to understand whether it is possible to predict the accuracy of a single RO-retrieved topside by comparing the peak density and height of the retrieved profile to the true values. As a first step, a simulation study based on the use of the NeQuick2 model has been performed to show that when the RO-derived electron density peak and height match the true peak values, the full topside Ne(h)-profile may be considered accurate. In order to validate this hypothesis with experimental data, electron density profiles obtained from four different incoherent scatter radars have therefore been considered together with co-located RO-derived Ne(h)-profiles. The evidence presented in this paper show that in all cases examined, if the incoherent scatter radar and the corresponding co-located RO profile have matching peak parameter values, their topsides are in very good agreement. The simulation results presented in this work also highlighted the importance of considering the occultation plane azimuth while inverting RO data to obtain Ne(h)-profile. In particular, they have indicated that there is a preferred range of azimuths of the occultation plane (80°-100°) for which the difference between the "true" and the RO-retrieved Ne(h)-profile in the topside is generally minimal.

Whole Tumor Histogram-profiling of Diffusion-Weighted Magnetic Resonance Images Reflects Tumorbiological Features of Primary Central Nervous System Lymphoma.

PubMed

Schob, Stefan; Münch, Benno; Dieckow, Julia; Quäschling, Ulf; Hoffmann, Karl-Titus; Richter, Cindy; Garnov, Nikita; Frydrychowicz, Clara; Krause, Matthias; Meyer, Hans-Jonas; Surov, Alexey

2018-04-01

Diffusion weighted imaging (DWI) quantifies motion of hydrogen nuclei in biological tissues and hereby has been used to assess the underlying tissue microarchitecture. Histogram-profiling of DWI provides more detailed information on diffusion characteristics of a lesion than the standardly calculated values of the apparent diffusion coefficient (ADC)-minimum, mean and maximum. Hence, the aim of our study was to investigate, which parameters of histogram-profiling of DWI in primary central nervous system lymphoma can be used to specifically predict features like cellular density, chromatin content and proliferative activity. Pre-treatment ADC maps of 21 PCNSL patients (8 female, 13 male, 28-89 years) from a 1.5T system were used for Matlab-based histogram profiling. Results of histopathology (H&E staining) and immunohistochemistry (Ki-67 expression) were quantified. Correlations between histogram-profiling parameters and neuropathologic examination were calculated using SPSS 23.0. The lower percentiles (p10 and p25) showed significant correlations with structural parameters of the neuropathologic examination (cellular density, chromatin content). The highest percentile, p90, correlated significantly with Ki-67 expression, resembling proliferative activity. Kurtosis of the ADC histogram correlated significantly with cellular density. Histogram-profiling of DWI in PCNSL provides a comprehensible set of parameters, which reflect distinct tumor-architectural and tumor-biological features, and hence, are promising biomarkers for treatment response and prognosis. Copyright © 2018. Published by Elsevier Inc.

Evidence for different accretion regimes in GRO J1008-57

NASA Astrophysics Data System (ADS)

Kühnel, Matthias; Fürst, Felix; Pottschmidt, Katja; Kreykenbohm, Ingo; Ballhausen, Ralf; Falkner, Sebastian; Rothschild, Richard E.; Klochkov, Dmitry; Wilms, Jörn

2017-11-01

We present a comprehensive spectral analysis of the BeXRB GRO J1008-57 over a luminosity range of three orders of magnitude using NuSTAR, Suzaku, and RXTE data. We find significant evolution of the spectral parameters with luminosity. In particular, the photon index hardens with increasing luminosity at intermediate luminosities in the range 1036-1037 erg s-1. This evolution is stable and repeatedly observed over different outbursts. However, at the extreme ends of the observed luminosity range, we find that the correlation breaks down, with a significance level of at least 3.7σ. We conclude that these changes indicate transitions to different accretion regimes, which are characterized by different deceleration processes, such as Coulomb or radiation breaking. We compare our observed luminosity levels of these transitions to theoretical predications and discuss the variation of those theoretical luminosity values with fundamental neutron star parameters. Finally, we present detailed spectroscopy of the unique "triple peaked" outburst in 2014/15 which does not fit in the general parameter evolution with luminosity. The pulse profile on the other hand is consistent with what is expected at this luminosity level, arguing against a change in accretion geometry. In summary, GRO J1008-57 is an ideal target to study different accretion regimes due to the well-constrained evolution of its broad-band spectral continuum over several orders of magnitude in luminosity.

Performance and robustness of optimal fractional fuzzy PID controllers for pitch control of a wind turbine using chaotic optimization algorithms.

PubMed

Asgharnia, Amirhossein; Shahnazi, Reza; Jamali, Ali

2018-05-11

The most studied controller for pitch control of wind turbines is proportional-integral-derivative (PID) controller. However, due to uncertainties in wind turbine modeling and wind speed profiles, the need for more effective controllers is inevitable. On the other hand, the parameters of PID controller usually are unknown and should be selected by the designer which is neither a straightforward task nor optimal. To cope with these drawbacks, in this paper, two advanced controllers called fuzzy PID (FPID) and fractional-order fuzzy PID (FOFPID) are proposed to improve the pitch control performance. Meanwhile, to find the parameters of the controllers the chaotic evolutionary optimization methods are used. Using evolutionary optimization methods not only gives us the unknown parameters of the controllers but also guarantees the optimality based on the chosen objective function. To improve the performance of the evolutionary algorithms chaotic maps are used. All the optimization procedures are applied to the 2-mass model of 5-MW wind turbine model. The proposed optimal controllers are validated using simulator FAST developed by NREL. Simulation results demonstrate that the FOFPID controller can reach to better performance and robustness while guaranteeing fewer fatigue damages in different wind speeds in comparison to FPID, fractional-order PID (FOPID) and gain-scheduling PID (GSPID) controllers. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

Monitoring of performance and training in rowing.

PubMed

Mäestu, Jarek; Jürimäe, Jaak; Jürimäe, Toivo

2005-01-01

Rowing is a strength-endurance type of sport and competition performance depends on factors such as aerobic and anaerobic power, physical power, rowing technique and tactics. Therefore, a rower has to develop several capacities in order to be successful and a valid testing battery of a rower has to include parameters that are highly related to rowing performance. Endurance training is the mainstay in rowing. For the 2000 m race, power training at high velocities should be preferred to resistance training at low velocities in order to train more specifically during the off-season. The specific training of the international rower has to be approximately 70% of the whole training time. Several studies have reported different biochemical parameters for monitoring the training of rowers. There is some evidence that plasma leptin is more sensitive to training volume changes than specific stress hormones (e.g. cortisol, testosterone, growth hormone). In rowing, the stress hormone reactions to training volume and/or intensity changes are controversial. The Recovery-Stress Questionnaire for Athletes measures both stress and recovery, and may therefore be more effective than the previously used Borg ratio scale or the Profile of Mood States, which both focus mainly on the stress component. In the future, probably the most effective way to evaluate the training of rowers is to monitor both stress and recovery components at the same time, using both psychometric data together with the biochemical and performance parameters.

Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives.

PubMed

Demir Özkay, Ümide; Kaya, Ceren; Acar Çevik, Ulviye; Can, Özgür Devrim

2017-09-07

Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a - 3h . The chemical structures of the synthesized compounds were elucidated by spectroscopic methods. Test compounds were administered orally at a dose of 40 mg/kg to mice 24, 5 and 1 h before performing tail suspension, modified forced swimming, and activity cage tests. The obtained results showed that compounds 3c , 3d , 3f - 3h reduced the immobility time of mice as assessed in the tail suspension test. Moreover, in the modified forced swimming tests, the same compounds significantly decreased the immobility, but increased the swimming frequencies of mice, without any alteration in the climbing frequencies. These results, similar to the results induced by the reference drug fluoxetine (20 mg/kg, po), indicated the antidepressant-like activities of the compounds 3c , 3d , 3f - 3h . Owing to the fact that test compounds did not induce any significant alteration in the total number of spontaneous locomotor activities, the antidepressant-like effects of these derivatives seemed to be specific. In order to predict ADME parameters of the synthesized compounds 3a - 3h , some physicochemical parameters were calculated. The ADME prediction study revealed that all synthesized compounds may possess good pharmacokinetic profiles.

Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet.

PubMed

Balbaa, Mahmoud; El-Zeftawy, Marwa; Ghareeb, Doaa; Taha, Nabil; Mandour, Abdel Wahab

2016-01-01

The black cumin (Nigella sativa) "NS" or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538. The administration of NSO significantly induced the gene expression of insulin receptor compared to rats that did not receive NSO. Also, it upregulated the expression of insulin-like growth factor-1 and phosphoinositide-3 kinase, whereas the expression of ADAM-17 was downregulated. The expression of ADAM-17 is corroborated by the analysis of TIMP-3 content. In addition, the NSO significantly reduced blood glucose level, components of the lipid profile, oxidative stress parameters, serum insulin/insulin receptor ratio, and the tumor necrosis factor-α, confirming that NSO has an antidiabetic activity. Thus, the daily NSO treatment in our rat model indicates that NSO has a potential in the management of diabetes as well as improvement of insulin-induced signaling.

Meat quality and intramuscular fatty acid composition of Catria Horse.

PubMed

Trombetta, Maria Federica; Nocelli, Francesco; Pasquini, Marina

2017-08-01

In order to extend scientific knowledge on autochthonous Italian equine meat, the physical-chemical parameters of Catria Horse Longissimus thoracis (LT) muscle and its nutritional characteristics have been investigated. Ten steaks of Catria foal raised at pasture and fattened indoors for 2 months were dissected, and LT muscle was analyzed for chemical composition, total iron, drip loss, colorimetric characteristics, intramuscular fat, fatty acid profile and nutritional indexes. Steak dissection showed that LT muscle accounted for 36.78% and fat accounted for 9.19% of weight of steak. Regarding chemical composition, protein and fat content was 20.31% and 2.83%, respectively. Total iron content (1.95 mg/100 g) was lower than data reported in the literature. Color parameters showed a luminous and intense red hue muscle. The sum of unsaturated fatty acid composition (50.3%) was higher than the sum of saturated fatty acids (46.64 %). The fatty acid profile and nutritional values of Catria Horse meat could be modified adopting extensive rearing systems and grazing. The data suggests that further investigation on the composition of Catria Horse meat should be carried out to valorize this autochthonous breed, reared in sustainable livestock systems, and its meat in local short-chain systems. © 2016 Japanese Society of Animal Science.

Wine aromatic compound production and fermentative behaviour within different non-Saccharomyces species and clones.

PubMed

Escribano, R; González-Arenzana, L; Portu, J; Garijo, P; López-Alfaro, I; López, R; Santamaría, P; Gutiérrez, A R

2018-06-01

Twenty-five enological yeasts belonging to nine different species (Candida zeylanoides, Cryptococcus uzbekistanensis, Debaryomyces hansenii, Lachancea thermotolerans, Metschnikowia pulcherrima, Torulaspora delbrueckii, Williopsis pratensis, Zygosaccharomyces bailii and Saccharomyces cerevisiae) were screened for aroma formation and fermentative behaviour as part of a non-Saccharomyces yeast selection programme. Pure cultures were inoculated in pasteurized grape juice in order to perform alcoholic fermentations. Some non-Saccharomyces species did not ferment, others did not get established and none of them completed alcoholic fermentations. The physico-chemical parameters of the wines and the abundance of aromatic compounds at the end of alcoholic fermentation highlighted the notable differences in the aroma-forming ability and fermentative behaviour of the different non-Saccharomyces species, but not within clones. Lower diversity was detected within non-Saccharomyces species than that reported in S. cerevisiae with regard to enological behaviour and aromatic profiles. Metschnikowia pulcherrima and L. thermotolerans are the two species with higher possibilities to become an inoculum. Few significant differences were found within clones of the same species, but very important parameters in wine quality, such as volatile acidity, ethyl acetate and acetoin, which would justify selection programmes within those species. The results also demonstrated that T. delbrueckii and L. thermotolerans are two close species in their aromatic profiles. © 2018 The Society for Applied Microbiology.

Optimal design of high-rise buildings with respect to fundamental eigenfrequency

NASA Astrophysics Data System (ADS)

Alavi, Arsalan; Rahgozar, Reza; Torkzadeh, Peyman; Hajabasi, Mohamad Ali

2017-12-01

In modern tall and slender structures, dynamic responses are usually the dominant design requirements, instead of strength criteria. Resonance is often a threatening phenomenon for such structures. To avoid this problem, the fundamental eigenfrequency, an eigenfrequency of higher order, should be maximized. An optimization problem with this objective is constructed in this paper and is applied to a high-rise building. Using variational method, the objective function is maximized, contributing to a particular profile for the first mode shape. Based on this preselected profile, a parametric formulation for flexural stiffness is calculated. Due to some near-zero values for stiffness, the obtained formulation will be modified by adding a lower bound constraint. To handle this constraint some new parameters are introduced; thereby allowing for construction of a model relating the unknown parameters. Based on this mathematical model, a design algorithmic procedure is presented. For the sake of convenience, a single-input design graph is presented as well. The main merit of the proposed method, compared to previous researches, is its hand calculation aspect, suitable for parametric studies and sensitivity analysis. As the presented formulations are dimensionless, they are applicable in any dimensional system. Accuracy and practicality of the proposed method is illustrated at the end by applying it to a real-life structure.

Bioreactor process parameter screening utilizing a Plackett-Burman design for a model monoclonal antibody.

PubMed

Agarabi, Cyrus D; Schiel, John E; Lute, Scott C; Chavez, Brittany K; Boyne, Michael T; Brorson, Kurt A; Khan, Mansoora; Read, Erik K

2015-06-01

Consistent high-quality antibody yield is a key goal for cell culture bioprocessing. This endpoint is typically achieved in commercial settings through product and process engineering of bioreactor parameters during development. When the process is complex and not optimized, small changes in composition and control may yield a finished product of less desirable quality. Therefore, changes proposed to currently validated processes usually require justification and are reported to the US FDA for approval. Recently, design-of-experiments-based approaches have been explored to rapidly and efficiently achieve this goal of optimized yield with a better understanding of product and process variables that affect a product's critical quality attributes. Here, we present a laboratory-scale model culture where we apply a Plackett-Burman screening design to parallel cultures to study the main effects of 11 process variables. This exercise allowed us to determine the relative importance of these variables and identify the most important factors to be further optimized in order to control both desirable and undesirable glycan profiles. We found engineering changes relating to culture temperature and nonessential amino acid supplementation significantly impacted glycan profiles associated with fucosylation, β-galactosylation, and sialylation. All of these are important for monoclonal antibody product quality. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association.

Flow Cytometry: Impact On Early Drug Discovery

PubMed Central

Edwards, Bruce S.; Sklar, Larry A.

2015-01-01

Summary Modern flow cytometers can make optical measurements of 10 or more parameters per cell at tens-of-thousands of cells per second and over five orders of magnitude dynamic range. Although flow cytometry is used in most drug discovery stages, “sip-and-spit” sampling technology has restricted it to low sample throughput applications. The advent of HyperCyt sampling technology has recently made possible primary screening applications in which tens-of-thousands of compounds are analyzed per day. Target-multiplexing methodologies in combination with extended multi-parameter analyses enable profiling of lead candidates early in the discovery process, when the greatest numbers of candidates are available for evaluation. The ability to sample small volumes with negligible waste reduces reagent costs, compound usage and consumption of cells. Improved compound library formatting strategies can further extend primary screening opportunities when samples are scarce. Dozens of targets have been screened in 384- and 1536-well assay formats, predominantly in academic screening lab settings. In concert with commercial platform evolution and trending drug discovery strategies, HyperCyt-based systems are now finding their way into mainstream screening labs. Recent advances in flow-based imaging, mass spectrometry and parallel sample processing promise dramatically expanded single cell profiling capabilities to bolster systems level approaches to drug discovery. PMID:25805180

Resistive switching near electrode interfaces: Estimations by a current model

NASA Astrophysics Data System (ADS)

Schroeder, Herbert; Zurhelle, Alexander; Stemmer, Stefanie; Marchewka, Astrid; Waser, Rainer

2013-02-01

The growing resistive switching database is accompanied by many detailed mechanisms which often are pure hypotheses. Some of these suggested models can be verified by checking their predictions with the benchmarks of future memory cells. The valence change memory model assumes that the different resistances in ON and OFF states are made by changing the defect density profiles in a sheet near one working electrode during switching. The resulting different READ current densities in ON and OFF states were calculated by using an appropriate simulation model with variation of several important defect and material parameters of the metal/insulator (oxide)/metal thin film stack such as defect density and its profile change in density and thickness, height of the interface barrier, dielectric permittivity, applied voltage. The results were compared to the benchmarks and some memory windows of the varied parameters can be defined: The required ON state READ current density of 105 A/cm2 can only be achieved for barriers smaller than 0.7 eV and defect densities larger than 3 × 1020 cm-3. The required current ratio between ON and OFF states of at least 10 requests defect density reduction of approximately an order of magnitude in a sheet of several nanometers near the working electrode.

Lithium-ion battery cell-level control using constrained model predictive control and equivalent circuit models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xavier, MA; Trimboli, MS

This paper introduces a novel application of model predictive control (MPC) to cell-level charging of a lithium-ion battery utilizing an equivalent circuit model of battery dynamics. The approach employs a modified form of the MPC algorithm that caters for direct feed-though signals in order to model near-instantaneous battery ohmic resistance. The implementation utilizes a 2nd-order equivalent circuit discrete-time state-space model based on actual cell parameters; the control methodology is used to compute a fast charging profile that respects input, output, and state constraints. Results show that MPC is well-suited to the dynamics of the battery control problem and further suggestmore » significant performance improvements might be achieved by extending the result to electrochemical models. (C) 2015 Elsevier B.V. All rights reserved.« less

Fast novel nonlinear optical NLC system with local response

NASA Astrophysics Data System (ADS)

Iljin, Andrey; Residori, Stefania; Bortolozzo, Umberto

2017-06-01

Nonlinear optical performance of a novel liquid crystalline (LC) cell has been studied in two-wave mixing experiments revealing high diffraction efficiency within extremely wide intensity range, fast recording times and spatial resolution. Photo-induced modulation of the LC order parameter resulting from trans-cis isomerisation of dye molecules causes consequent changes of refractive indices of the medium (Light-Induced Order Modification, LIOM-mechanism) and is proved to be the main mechanism of optical nonlinearity. The proposed arrangement of the electric-field-stabilised homeotropic alignment hinders the LC director reorientation, prevents appearance of surface effects and ensures the optical cell quality. The LIOM-type nonlinearity, characterised with the substantially local nonlinear optical response, could also be extended for the recording of arbitrary phase profiles as requested in several applications for light-beam manipulation, recording of dynamic volume holograms and photonic lattices.

Simultaneously phase-matched second- and third-harmonic generation from 1.55 microm radiation in annealed proton-exchanged periodically poled lithium niobate waveguides.

PubMed

Marangoni, M; Lobino, M; Ramponi, R

2006-09-15

Third-harmonic generation (THG) in the cw regime from C-band radiation was achieved in annealed proton-exchanged periodically poled lithium niobate (PPLN) waveguides. By suitable design of fabrication parameters and operating conditions, quasi-phase-matching (QPM) is obtained simultaneously for the second-harmonic generation process (omega-->2omega, first-order QPM) and for the sum-frequency-generation process (omega+2omega-->3omega, third-order QPM), which provides the third harmonic of the pump field. The high overlap between the field profiles of the interacting modes--TM00 at omega and TM10 at 2omega and 3omega--results in what is believed to be the highest ever reported normalized conversion efficiency for THG from telecommunication wavelengths, equal to 0.72%W(-2) cm(-4).

Electrostatic and hydrodynamics effects in a sedimented magnetorheological suspension.

PubMed

Domínguez-García, P; Pastor, J M; Melle, Sonia; Rubio, Miguel A

2009-08-01

We present experimental results on the equilibrium microstructure of a sedimented magnetorheological suspension, namely, an aqueous suspension of micron-sized superparamagnetic particles. We develop a study of the electrical interactions on the suspension by processing video-microscopy images of the sedimented particles. We calculate the pair distribution function, g(r), which yields the electrostatic pair potential u(r), showing an anomalous attractive interaction for distances on the order of twice the particle diameter, with characteristic parameters whose values show a dependence with the two-dimensional concentration of particles. The repulsive body of the potential is adjusted to a DLVO expression in order to calculate the Debye screening length and the effective surface charge density. Influence of confinement and variations on the Boltzmann sedimentation profile because of the electrostatic interactions appear to be essential for the interpretation of experimental results.

Dependence of sound characteristics on the bowing position in a violin

NASA Astrophysics Data System (ADS)

Roh, YuJi; Kim, Young H.

2014-12-01

A quantitative analysis of violin sounds produced for different bowing positions over the full length of a violin string has been carried out. An automated bowing machine was employed in order to keep the bowing parameters constant. A 3-dimensional profile of the frequency spectrum was introduced in order to characterize the violin's sound. We found that the fundamental frequency did not change for different bowing positions, whereas the frequencies of the higher harmonics were different. Bowing the string at 30 mm from the bridge produced musical sounds. The middle of the string was confirmed to be a dead zone, as reported in previous works. In addition, the quarter position was also found to be a dead zone. Bowing the string 90 mm from the bridge dominantly produces a fundamental frequency of 864 Hz and its harmonics.

Multisensor Retrieval of Atmospheric Properties.

NASA Astrophysics Data System (ADS)

Boba Stankov, B.

1998-09-01

A new method, Multisensor Retrieval of Atmospheric Properties (MRAP), is presented for deriving vertical profiles of atmospheric parameters throughout the troposphere. MRAP integrates measurements from multiple, diverse, remote sensing, and in situ instruments, the combination of which provides better capabilities than any instrument alone. Since remote sensors can deliver measurements automatically and continuously with high time resolution, MRAP provides better coverage than traditional rawinsondes. MRAP's design is flexible, being capable of incorporating measurements from different instruments in order to take advantage of new or developing advanced sensor technology. Furthermore, new or alternative atmospheric parameters for a variety of applications may be easily added as products of MRAP.A combination of passive radiometric, active radar, and in situ observations provide the best temperature and humidity profile measurements. Therefore, MRAP starts with a traditional, radiometer-based, physical retrieval algorithm provided by the International TOVS (TIROS-N Operational Vertical Sounder) Processing Package (ITPP) that constrains the retrieved profiles to agree with brightness temperature measurements. The first-guess profiles required by the ITPP's iterative retrieval algorithm are obtained by using a statistical inversion technique and ground-based remote sensing measurements. Because the individual ground-based remote sensing measurements are usually of sufficiently high quality, the first-guess profiles by themselves provide a satisfactory solution to establish the atmospheric water vapor and temperature state, and the TOVS data are included to provide profiles with better accuracy at higher levels, MRAP provides a physically consistent mechanism for combining the ground- and space-based humidity and temperature profiles.Data that have been used successfully to retrieve humidity and temperature profiles with MRAP are the following: temperature profiles in the lower troposphere from the ground-based Radio Acoustic Sounding System (RASS); total water vapor measurements from the Global Positioning System; specific humidity gradient profiles from the wind-profiling radar/RASS system; surface meteorological observations from standard instruments; cloud-base heights from a lidar ceilometer; temperature from the Aeronautical Radio, Incorporated Communication, Addressing and Reporting System aboard commercial airlines; and brightness temperature observations from TOVS.Data from the experiment conducted in the late summer of 1995 at Point Loma, California, were used for comparisons of MRAP results and 20 nearby rawinsonde releases to assess the statistical error estimates of MRAP. The temperature profiles had a bias of -0.27°C and a standard deviation of 1.56°C for the entire troposphere. Dewpoint profile retrievals did not have an overall accuracy as high as that of the temperature profiles but they exhibited a markedly improved standard deviation and bias in the lower atmosphere when the wind profiler/RASS specific humidity gradient information was available as a further constraint on the process. The European Centre for Medium-Range Weather Forecasts (ECMWF) model profiles of humidity and temperature for the grid point nearest to the Point Loma site were also used for comparison with the rawinsonde soundings to establish the usefulness of MRAP profiles to the weather forecasting community. The comparison showed that the vertical resolution of the ECMWF model profiles within the planetary boundary layer is not capable of detecting sharp gradients.

UNDERSTANDING HARD ROCK HYDROGEOLOGY THROUGH AN EXPERIMENTAL HYDROGEOLOGICAL PARK IN SOUTH INDIA: Site development and investigations on the major role of the fractured zone in crystalline aquifers

NASA Astrophysics Data System (ADS)

Ahmed, S.; Guiheneuf, N.; Boisson, A.; Marechal, J.; Chandra, S.; Dewandel, B.; Perrin, J.

2012-12-01

In water stressed south India most of the groundwater used for irrigation is pumped from crystalline rocks aquifers. In those structures groundwater flow dominantly occur in a shallow higher-permeability zone that overlies a deeper lower-permeability zone hosting little flow. The fractured zone of the weathering profile plays an important role for groundwater. In order to understand clearly this impact on water availability and quality changes the Experimental Hydrogeological Park at Choutuppal, Andhra Pradesh, India is developed in the framework of the SORE H+ network. Several hydraulic tests (injection, flowmeter profiles, single-packer tests…) and geophysical measurements (ERT, Borehole logging…) are carried out on the site in order to characterize the depth-dependence of hydrodynamic parameters in the Indian Archean granite. Specific investigation on a borewell through packer tests demonstrate that the most conductive part of the aquifer corresponds to the upper part of the fractured layer, located just below the saprolite bottom, between 15 meters and 20 meters depth. There is no highly conductive fracture beyond 20 meters depth and no indication for any conductive fracture beyond 25 meters depth. Packer tests show that the upper part of the fractured layer (15-20 m depth) is characterized by a good vertical connectivity. On the contrary, the tests carried out below 20 m depth show no vertical connectivity at all. The geometry of the fracture network and associated hydrodynamic parameters are in agreement with the conceptual model of hard-rock aquifers that derive its properties from weathering processes. The general existence of such a highly conductive structure at the top of the fractured zone has a great impact on water prospection and exploitation in such crystalline aquifers.

Experimental study on interfacial area transport in downward two-phase flow

NASA Astrophysics Data System (ADS)

Wang, Guanyi

In view of the importance of two group interfacial area transport equations and lack of corresponding accurate downward flow database that can reveal two group interfacial area transport, a systematic database for adiabatic, air-water, vertically downward two-phase flow in a round pipe with inner diameter of 25.4 mm was collected to gain an insight of interfacial structure and provide benchmarking data for two-group interfacial area transport models. A four-sensor conductivity probe was used to measure the local two phase flow parameters and data was collected with data sampling frequency much higher than conventional data sampling frequency to ensure the accuracy. Axial development of local flow parameter profiles including void fraction, interfacial area concentration, and Sauter mean diameter were presented. Drastic inter-group transfer of void fraction and interfacial area was observed at bubbly to slug transition flow. And the wall peaked interfacial area concentration profiles were observed in churn-turbulent flow. The importance of local data about these phenomenon on flow structure prediction and interfacial area transport equation benchmark was analyzed. Bedsides, in order to investigate the effect of inlet conditions, all experiments were repeated after installing the flow straightening facility, and the results were briefly analyzed. In order to check the accuracy of current data, the experiment results were cross-checked with rotameter measurement as well as drift-flux model prediction, the averaged error is less than 15%. Current models for two-group interfacial area transport equation were evaluated using these data. The results show that two-group interfacial area transport equations with current models can predict most flow conditions with error less than 20%, except some bubbly to slug transition flow conditions and some churn-turbulent flow conditions. The disagreement between models and experiments could result from underestimate of inter-group void transfer.

Free energy landscape and molecular pathways of gas hydrate nucleation.

PubMed

Bi, Yuanfei; Porras, Anna; Li, Tianshu

2016-12-07

Despite the significance of gas hydrates in diverse areas, a quantitative knowledge of hydrate formation at a molecular level is missing. The impediment to acquiring this understanding is primarily attributed to the stochastic nature and ultra-fine scales of nucleation events, posing a great challenge for both experiment and simulation to explore hydrate nucleation. Here we employ advanced molecular simulation methods, including forward flux sampling (FFS), p B histogram analysis, and backward flux sampling, to overcome the limit of direct molecular simulation for exploring both the free energy landscape and molecular pathways of hydrate nucleation. First we test the half-cage order parameter (H-COP) which we developed for driving FFS, through conducting the p B histogram analysis. Our results indeed show that H-COP describes well the reaction coordinates of hydrate nucleation. Through the verified order parameter, we then directly compute the free energy landscape for hydrate nucleation by combining both forward and backward flux sampling. The calculated stationary distribution density, which is obtained independently of nucleation theory, is found to fit well against the classical nucleation theory (CNT). Subsequent analysis of the obtained large ensemble of hydrate nucleation trajectories show that although on average, hydrate formation is facilitated by a two-step like mechanism involving a gradual transition from an amorphous to a crystalline structure, there also exist nucleation pathways where hydrate crystallizes directly, without going through the amorphous stage. The CNT-like free energy profile and the structural diversity suggest the existence of multiple active transition pathways for hydrate nucleation, and possibly also imply the near degeneracy in their free energy profiles among different pathways. Our results thus bring a new perspective to the long standing question of how hydrates crystallize.

Correlations Between Anthropometry and Lipid Profile in Women With PCOS.

PubMed

Kiranmayee, Donthu; Kavya, Kothapalli; Himabindu, Yalamanchali; Sriharibabu, Manne; Madhuri, Gadi Leela Jaya; Venu, Swargam

2017-01-01

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive age women and is associated with both reproductive and metabolic abnormalities. Recent studies have demonstrated an early onset of abnormal cardiovascular risk profile in women with PCOS. Abnormal lipid profile patterns are common in women with PCOS, and these abnormalities are not uniform in all populations. Anthropometry is a simple and commonly used research tool for assessing metabolic risk in women with PCOS. Therefore, this study examined the correlations between anthropometric parameters and lipid profile in women with PCOS. The objectives of the study were (1) To study the anthropometric profile of women with PCOS, (2) To examine the lipid profile pattern of these women with PCOS and (3) To see whether there exists any correlation between these anthropometric parameters and lipid profile. This observational cross-sectional study examined anthropometry and lipid profile in 86 married women with PCOS in the age group of 18-35 years and correlated them by using Pearson's correlation coefficient. More than 80% of the women with PCOS demonstrated abnormal anthropometric parameters, and in more than 70% women, lipid abnormalities such as low levels of high-density lipoprotein (HDL) cholesterol and high levels of triglycerides and low-density lipoprotein cholesterol were observed. Significant positive correlations were seen between body mass index (BMI) and triglycerides ( P ≤ 0.001) and waist circumference (WC) and triglycerides ( P ≤ 0.029). Negative correlations were observed between BMI and HDL cholesterol ( P ≤ 0.013). This study revealed that BMI and WC are the most important anthropometric parameters correlated to dyslipidemia in the south Indian women with PCOS.

Characteristics of nocturnal coastal boundary layer in Ahtopol based on averaged SODAR profiles

NASA Astrophysics Data System (ADS)

Barantiev, Damyan; Batchvarova, Ekaterina; Novitzky, Mikhail

2014-05-01

The ground-based remote sensing instruments allow studying the wind regime and the turbulent characteristics of the atmosphere with height, achieving new knowledge and solving practical problems, such as air quality assessments, mesoscale models evaluation with high resolution data, characterization of the exchange processes between the surface and the atmosphere, the climate comfort conditions and the risk for extreme events, etc. Very important parameter in such studies is the height of the atmospheric boundary layer. Acoustic remote sensing data of the coastal atmospheric boundary layer were explored based on over 4-years continuous measurements at the meteorological observatory of Ahtopol (Bulgarian Southern Black Sea Coast) under Bulgarian - Russian scientific agreement. Profiles of 12 parameters from a mid-range acoustic sounding instrument type SCINTEC MFAS are derived and averaged up to about 600 m according filtering based on wind direction (land or sea type of night fowls). From the whole investigated period of 1454 days with 10-minute resolution SODAR data 2296 profiles represented night marine air masses and 1975 profiles represented the night flow from land during the months May to September. Graphics of averaged profiles of 12 SODAR output parameters with different availability of data in height are analyzed for both cases. A marine boundary-layer height of about 300 m is identified in the profiles of standard deviation of vertical wind speed (σw), Turbulent Kinetic Energy (TKE) and eddy dissipation rate (EDR). A nocturnal boundary-layer height of about 420 m was identified from the profiles of the same parameters under flows from land condition. In addition, the Buoyancy Production (BP= σw3/z) profiles were calculated from the standard deviation of the vertical wind speed and the height z above ground.

A system for online beam emittance measurements and proton beam characterization

NASA Astrophysics Data System (ADS)

Nesteruk, K. P.; Auger, M.; Braccini, S.; Carzaniga, T. S.; Ereditato, A.; Scampoli, P.

2018-01-01

A system for online measurement of the transverse beam emittance was developed. It is named 4PrOBεaM (4-Profiler Online Beam Emittance Measurement) and was conceived to measure the emittance in a fast and efficient way using the multiple beam profiler method. The core of the system is constituted by four consecutive UniBEaM profilers, which are based on silica fibers passing across the beam. The 4PrOBεaM system was deployed for characterization studies of the 18 MeV proton beam produced by the IBA Cyclone 18 MeV cyclotron at Bern University Hospital (Inselspital). The machine serves daily radioisotope production and multi-disciplinary research, which is carried out with a specifically conceived Beam Transport Line (BTL). The transverse RMS beam emittance of the cyclotron was measured as a function of several machine parameters, such as the magnetic field, RF peak voltage, and azimuthal angle of the stripper. The beam emittance was also measured using the method based on the quadrupole strength variation. The results obtained with both techniques were compared and a good agreement was found. In order to characterize the longitudinal dynamics, the proton energy distribution was measured. For this purpose, a method was developed based on aluminum absorbers of different thicknesses, a UniBEaM detector, and a Faraday cup. The results were an input for a simulation of the BTL developed in the MAD-X software. This tool allows machine parameters to be tuned online and the beam characteristics to be optimized for specific applications.

Bioequivalence of HX575 (recombinant human epoetin alfa) and a comparator epoetin alfa after multiple intravenous administrations: an open-label randomised controlled trial.

PubMed

Sörgel, Fritz; Thyroff-Friesinger, Ursula; Vetter, Andrea; Vens-Cappell, Bernhard; Kinzig, Martina

2009-05-22

HX575 is a human recombinant epoetin alfa that was approved for use in Europe in 2007 under the European Medicines Agency biosimilar approval pathway. Therefore, in order to demonstrate the bioequivalence of HX575 to an existing epoetin alfa, the pharmacokinetic and pharmacodynamic response to steady state circulating concentrations of HX575 and a comparator epoetin alfa were compared following multiple intravenous administrations. An open, randomised, parallel group study was conducted in 80 healthy adult males. Subjects were randomised to multiple intravenous doses of 100 IU/kg body weight of HX575 or of the comparator epoetin alfa three-times-weekly for four weeks. Serum epoetin concentrations were measured using an enzyme-linked immunosorbent assay and pharmacokinetic parameters for the two treatments were compared. The time course and area under the effect curve ratio of haematological characteristics were used as surrogate parameters for efficacy evaluation. The haematological profiles of both treatments were similar, as determined from their population mean curves and the AUECHb ratio and 90% confidence interval (99.9% [98.5-101.2%]), the primary pharmacodynamic endpoint of this study. The pharmacokinetic parameters after the treatments showed minor differences after single dosing, but not at steady state doses. After multiple doses, HX575 was bioequivalent to the comparator with respect to the rate and extent of exposure of exogenous epoetin (AUCtau ratio and 90% confidence interval: 89.2% [82.5-96.2%]). Study medication was well tolerated with no clinically relevant differences between safety profiles of the treatments. Anti-epoetin antibodies were not detected. HX575 and the comparator epoetin alfa were bioequivalent at steady state circulating drug concentrations with respect to their pharmacokinetic profile and pharmacodynamic action. This supports the conclusion that HX575 and the comparator epoetin alfa, when administered intraveneously, will be equally efficacious and may be interchangeable as therapy.

Winds in hot main-sequence stars near the static limit

NASA Technical Reports Server (NTRS)

Morrison, Nancy D.

1995-01-01

This project began with the acquisition of short-wavelength, high-dispersion IUE spectra of selected late O- and early B-type stars that are near the main sequence in open clusters and associations. The profiles of the resonance lines of N(V), Si(IV), and C(IV) were studied, and we found that the C(IV) lines are the most sensitive indicators of mass loss (stellar winds) in stars of this type. The mass loss manifests itself as an extension of the short-wavelength absorption wing of the doublet, while there is no P Cygni-type emission on the long-wavelength side of the line profile. We investigated whether the short-wavelength extension could be caused by blended lines of other ionic species formed in the photosphere. Although blending is present and introduces uncertainty into the estimation of the precise location on the main sequence of the onset of the mass-loss signature, it is a crucial issue only in a few marginal cases. Mass loss certainly overwhelms blending in its influence on the spectrum between spectral types B0 and B1 (effective temperatures in the range 25,000-27,000 K). We defined a parameter called P(sub w), to describe the degree of asymmetry of the C(IV) resonance-line profile, and we studied the dependence of this parameter on the fundamental stellar parameters. For this purpose, we derived new estimates of the stellar T(eff) and log g from a non-LTE, line-blanketed model-atmosphere analysis of these stars (Grigsby, Morrison, and Anderson 1992). In order to estimate the stellar luminosities, we performed an exhaustive search of the literature for the most reliable available estimates of the distances of the clusters and associations to which the program stars belong. The dependence of P(sub w) on stellar temperature and luminosity is also studied.

Synthesis and Structure of A New Perovskite, SrCuO 2.5

NASA Astrophysics Data System (ADS)

Chen, Bai-Hao; Walker, Dave; Scott, Bruce A.; Mitzi, David B.

1996-02-01

A new oxygen-deficient perovskite, SrCuO2.5, was prepared at 950°C and 100 kbar pressure in a multianvil apparatus. Rietveld profile analysis, using X-ray powder diffraction data, was employed for the structural determination. SrCuO2.5is orthorhombic,Pbam(No. 55),Z= 4,a= 5.424(2) Â,b= 10.837(4) Â, andc= 3.731(1) Â, which is related to the perovskite subcell by root{2}ap× 2root{2}ap×ap, whereapis the simple cubic perovskite lattice parameter. It consists of corner-shared CuO5square pyramids with oxygen vacancy ordering in the CuO2layers. The ordered oxygen vacancies create parallel pseudo-hexagonal tunnels where the Sr atoms reside, forming SrO10polyhedra. Structural features with respect to oxygen vacancies, superstructures, and distortions are analogous to the type of ordering observed in Sr2CuO3+δ. Superconductivity was not observed in SrCuO2.5down to 5 K.

Complex collective dynamics of active torque-driven colloids at interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snezhko, Alexey

Modern self-assembly techniques aiming to produce complex structural order or functional diversity often rely on non-equilibrium conditions in the system. Light, electric, or magnetic fields are predominantly used to modify interaction profiles of colloidal particles during self-assembly or induce complex out-of-equilibrium dynamic ordering. The energy injection rate, properties of the environment are important control parameters that influence the outcome of active (dynamic) self-assembly. The current review is focused on a case of collective dynamics and self-assembly of particles with externally driven torques coupled to a liquid or solid interface. The complexity of interactions in such systems is further enriched bymore » strong hydrodynamic coupling between particles. Unconventionally ordered dynamic self-assembled patterns, spontaneous symmetry breaking phenomena, self-propulsion, and collective transport have been reported in torque-driven colloids. Some of the features of the complex collective behavior and dynamic pattern formation in those active systems have been successfully captured in simulations.« less

Continuous piecewise-linear, reduced-order electrochemical model for lithium-ion batteries in real-time applications

NASA Astrophysics Data System (ADS)

Farag, Mohammed; Fleckenstein, Matthias; Habibi, Saeid

2017-02-01

Model-order reduction and minimization of the CPU run-time while maintaining the model accuracy are critical requirements for real-time implementation of lithium-ion electrochemical battery models. In this paper, an isothermal, continuous, piecewise-linear, electrode-average model is developed by using an optimal knot placement technique. The proposed model reduces the univariate nonlinear function of the electrode's open circuit potential dependence on the state of charge to continuous piecewise regions. The parameterization experiments were chosen to provide a trade-off between extensive experimental characterization techniques and purely identifying all parameters using optimization techniques. The model is then parameterized in each continuous, piecewise-linear, region. Applying the proposed technique cuts down the CPU run-time by around 20%, compared to the reduced-order, electrode-average model. Finally, the model validation against real-time driving profiles (FTP-72, WLTP) demonstrates the ability of the model to predict the cell voltage accurately with less than 2% error.

Continuous depth profile of mechanical properties in the Nankai accretionary prism based on drilling performance parameters

NASA Astrophysics Data System (ADS)

Hamada, Y.; Kitamura, M.; Yamada, Y.; Sanada, Y.; Moe, K.; Hirose, T.

2016-12-01

In-situ rock properties in/around seismogenic zone in an accretionary prism are key parameters to understand the development mechanisms of an accretionary prism, spatio-temporal variation of stress state, and so on. For the purpose of acquiring continuous-depth-profile of in-situ formation strength in an accretionary prism, here we propose the new method to evaluate the in-situ rock strength using drilling performance property. Drilling parameters are inevitably obtained by any drilling operation even in the non-coring intervals or at challenging environment where core recovery may be poor. The relationship between the rock properties and drilling parameters has been proposed by previous researches [e.g. Teale 1964]. We introduced the relationship theory of Teale [1964], and developed a converting method to estimate in-situ rock strength without depending on uncertain parameters such as weight on bit (WOB). Specifically, we first calculated equivalent specific toughness (EST) which represents gradient of the relationship between Torque energy and volume of penetration at arbitrary interval (in this study, five meters). Then the EST values were converted into strength using the drilling parameters-rock strengths correlation obtained by Karasawa et al. [2002]. This method was applied to eight drilling holes in the Site C0002 of IODP NanTroSEIZE in order to evaluate in-situ rock strength in shallow to deep accretionary prism. In the shallower part (0 - 300 mbsf), the calculated strength shows sharp increase up to 20 MPa. Then the strength has approximate constant value to 1500 mbsf without significant change even at unconformity around 1000 mbsf (boundary between forearc basin and accretionary prism). Below that depth, value of the strength gradually increases with depth up to 60 MPa at 3000 mbsf with variation between 10 and 80 MPa. Because the calculated strength is across approximately the same lithology, the increase trend can responds to the rock strength. This strength-depth curve correspond reasonably well with the strength data of core and cutting samples collected from hole C0002N and C0002P [Kitamura et al., 2016 AGU]. These results show the validity of the method evaluating in-situ strength from the drilling parameters.

AOF LTAO mode: reconstruction strategy and first test results

NASA Astrophysics Data System (ADS)

Oberti, Sylvain; Kolb, Johann; Le Louarn, Miska; La Penna, Paolo; Madec, Pierre-Yves; Neichel, Benoit; Sauvage, Jean-François; Fusco, Thierry; Donaldson, Robert; Soenke, Christian; Suárez Valles, Marcos; Arsenault, Robin

2016-07-01

GALACSI is the Adaptive Optics (AO) system serving the instrument MUSE in the framework of the Adaptive Optics Facility (AOF) project. Its Narrow Field Mode (NFM) is a Laser Tomography AO (LTAO) mode delivering high resolution in the visible across a small Field of View (FoV) of 7.5" diameter around the optical axis. From a reconstruction standpoint, GALACSI NFM intends to optimize the correction on axis by estimating the turbulence in volume via a tomographic process, then projecting the turbulence profile onto one single Deformable Mirror (DM) located in the pupil, close to the ground. In this paper, the laser tomographic reconstruction process is described. Several methods (virtual DM, virtual layer projection) are studied, under the constraint of a single matrix vector multiplication. The pseudo-synthetic interaction matrix model and the LTAO reconstructor design are analysed. Moreover, the reconstruction parameter space is explored, in particular the regularization terms. Furthermore, we present here the strategy to define the modal control basis and split the reconstruction between the Low Order (LO) loop and the High Order (HO) loop. Finally, closed loop performance obtained with a 3D turbulence generator will be analysed with respect to the most relevant system parameters to be tuned.

Darboux transformation of the coupled nonisospectral Gross-Pitaevskii system and its multi-component generalization

NASA Astrophysics Data System (ADS)

Xu, Tao; Chen, Yong

2018-04-01

In this paper, we extend the one-component Gross-Pitaevskii (GP) equation to the two-component coupled GP system including damping term, linear and parabolic density profiles. The Lax pair with nonisospectral parameter and infinitely-many conservation laws of this coupled GP system are presented. Actually, the Darboux transformation (DT) for this kind of nonautonomous system is essentially different from the autonomous case. Consequently, we construct the DT of the coupled GP equations, besides, nonautonomous multi-solitons, one-breather and the first-order rogue wave are also obtained. Various kinds of one-soliton solution are constructed, which include stationary one-soliton and nonautonomous one-soliton propagating along the negative (positive) direction of x-axis. The interaction of two solitons and two-soliton bound state are demonstrated respectively. We get the nonautonomous one-breather on a curved background and this background is completely controlled by the parameter β. Using a limiting process, the nonautonomous first-order rogue wave can be obtained. Furthermore, some dynamic structures of these analytical solutions are discussed in detail. In addition, the multi-component generalization of GP equations are given, then the corresponding Lax pair and DT are also constructed.

Adaptive model reduction for continuous systems via recursive rational interpolation

NASA Technical Reports Server (NTRS)

Lilly, John H.

1994-01-01

A method for adaptive identification of reduced-order models for continuous stable SISO and MIMO plants is presented. The method recursively finds a model whose transfer function (matrix) matches that of the plant on a set of frequencies chosen by the designer. The algorithm utilizes the Moving Discrete Fourier Transform (MDFT) to continuously monitor the frequency-domain profile of the system input and output signals. The MDFT is an efficient method of monitoring discrete points in the frequency domain of an evolving function of time. The model parameters are estimated from MDFT data using standard recursive parameter estimation techniques. The algorithm has been shown in simulations to be quite robust to additive noise in the inputs and outputs. A significant advantage of the method is that it enables a type of on-line model validation. This is accomplished by simultaneously identifying a number of models and comparing each with the plant in the frequency domain. Simulations of the method applied to an 8th-order SISO plant and a 10-state 2-input 2-output plant are presented. An example of on-line model validation applied to the SISO plant is also presented.

Probing the tides in interacting galaxy pairs

NASA Technical Reports Server (NTRS)

Borne, Kirk D.

1990-01-01

Detailed spectroscopic and imaging observations of colliding elliptical galaxies revealed unmistakable diagnostic signatures of the tidal interactions. It is possible to compare both the distorted luminosity distributions and the disturbed internal rotation profiles with numerical simulations in order to model the strength of the tidal gravitational field acting within a given pair of galaxies. Using the best-fit numerical model, one can then measure directly the mass of a specific interacting binary system. This technique applies to individual pairs and therefore complements the classical methods of measuring the masses of galaxy pairs in well-defined statistical samples. The 'personalized' modeling of galaxy pairs also permits the derivation of each binary's orbit, spatial orientation, and interaction timescale. Similarly, one can probe the tides in less-detailed observations of disturbed galaxies in order to estimate some of the physical parameters for larger samples of interacting galaxy pairs. These parameters are useful inputs to the more universal problems of (1) the galaxy merger rate, (2) the strength and duration of the driving forces behind tidally stimulated phenomena (e.g., starbursts and maybe quasi steller objects), and (3) the identification of long-lived signatures of interaction/merger events.

Neural network evaluation of tokamak current profiles for real time control

NASA Astrophysics Data System (ADS)

Wróblewski, Dariusz

1997-02-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental datais demonstrated.

Neural network evaluation of tokamak current profiles for real time control (abstract)

NASA Astrophysics Data System (ADS)

Wróblewski, Dariusz

1997-01-01

Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental data is demonstrated.

Model and Comparative Study for Flow of Viscoelastic Nanofluids with Cattaneo-Christov Double Diffusion

PubMed Central

Hayat, Tasawar; Aziz, Arsalan; Muhammad, Taseer; Alsaedi, Ahmed

2017-01-01

Here two classes of viscoelastic fluids have been analyzed in the presence of Cattaneo-Christov double diffusion expressions of heat and mass transfer. A linearly stretched sheet has been used to create the flow. Thermal and concentration diffusions are characterized firstly by introducing Cattaneo-Christov fluxes. Novel features regarding Brownian motion and thermophoresis are retained. The conversion of nonlinear partial differential system to nonlinear ordinary differential system has been taken into place by using suitable transformations. The resulting nonlinear systems have been solved via convergent approach. Graphs have been sketched in order to investigate how the velocity, temperature and concentration profiles are affected by distinct physical flow parameters. Numerical values of skin friction coefficient and heat and mass transfer rates at the wall are also computed and discussed. Our observations demonstrate that the temperature and concentration fields are decreasing functions of thermal and concentration relaxation parameters. PMID:28046011

Advection-diffusion model for the simulation of air pollution distribution from a point source emission

NASA Astrophysics Data System (ADS)

Ulfah, S.; Awalludin, S. A.; Wahidin

2018-01-01

Advection-diffusion model is one of the mathematical models, which can be used to understand the distribution of air pollutant in the atmosphere. It uses the 2D advection-diffusion model with time-dependent to simulate air pollution distribution in order to find out whether the pollutants are more concentrated at ground level or near the source of emission under particular atmospheric conditions such as stable, unstable, and neutral conditions. Wind profile, eddy diffusivity, and temperature are considered in the model as parameters. The model is solved by using explicit finite difference method, which is then visualized by a computer program developed using Lazarus programming software. The results show that the atmospheric conditions alone influencing the level of concentration of pollutants is not conclusive as the parameters in the model have their own effect on each atmospheric condition.

Left ventricular longitudinal strain in soccer referees.

PubMed

Gianturco, Luigi; Bodini, Bruno; Gianturco, Vincenzo; Lippo, Giuseppina; Solbiati, Agnese; Turiel, Maurizio

2017-06-13

Along the years, the analysis of soccer referees perfomance has interested the experts and we can find several types of studies in literature using in particular cardiac imaging. The aim of this retrospective study was to observe relationship between VO2max uptake and some conventional and not-conventional echocardiographic parameters. In order to perform this evaluation, we have enrolled 20 referees, belonging to Italian Soccer Referees' Association and we have investigated cardiovascular profile of them. We found a strong direct relationship between VO2max and global longitudinal strain of left ventricle assessed by means of speckle tracking echocardiographic analysis (R2=0.8464). The most common classic echocardiographic indexes have showed mild relations (respectively, VO2max vs EF: R2=0.4444; VO2max vs LV indexed mass: R2=0.2268). Therefore, our study suggests that longitudinal strain could be proposed as a specific echocardiographic parameter to evaluate the soccer referees performance.

Comparison of fate profiles of PAHs in soil, sediments and mangrove leaves after oil spills by QSAR and QSPR.

PubMed

Tansel, Berrin; Lee, Mengshan; Tansel, Derya Z

2013-08-15

First order removal rates for 15 polyaromatic hydrocarbons (PAHs) in soil, sediments and mangrove leaves were compared in relation to the parameters used in fate transport analyses (i.e., octanol-water partition coefficient, organic carbon-water partition coefficient, solubility, diffusivity in water, HOMO-LUMO gap, molecular size, molecular aspect ratio). The quantitative structure activity relationships (QSAR) and quantitative structure property relationships (QSPR) showed that the rate of disappearance of PAHs is correlated with their diffusivities in water as well as molecular volumes in different media. Strong correlations for the rate of disappearance of PAHs in sediments could not be obtained in relation to most of the parameters evaluated. The analyses showed that the QSAR and QSPR correlations developed for removal rates of PAHs in soils would not be adequate for sediments and plant tissues. Copyright © 2013 Elsevier Ltd. All rights reserved.

The river absorption capacity determination as a tool to evaluate state of surface water

NASA Astrophysics Data System (ADS)

Wilk, Paweł; Orlińska-Woźniak, Paulina; Gębala, Joanna

2018-02-01

In order to complete a thorough and systematic assessment of water quality, it is useful to measure the absorption capacity of a river. Absorption capacity is understood as a pollution load introduced into river water that will not cause permanent and irreversible changes in the aquatic ecosystem and will not cause a change in the classification of water quality in the river profile. In order to implement the method, the Macromodel DNS/SWAT basin for the Middle Warta pilot (central Poland) was used to simulate nutrient loads. This enabled detailed analysis of water quality in each water body and the assessment of the size of the absorption capacity parameter, which allows the determination of how much pollution can be added to the river without compromising its quality class. Positive values of the calculated absorption capacity parameter mean that it is assumed that the ecosystem is adjusted in such a way that it can eliminate pollution loads through a number of self-purification processes. Negative values indicate that the load limit has been exceeded, and too much pollution has been introduced into the ecosystem for it to be able to deal with through the processes of self-purification. Absorption capacity thus enables the connection of environmental standards of water quality and water quality management plans in order to meet these standards.

Membrane Perturbation Induced by Interfacially Adsorbed Peptides

PubMed Central

Zemel, Assaf; Ben-Shaul, Avinoam; May, Sylvio

2004-01-01

The structural and energetic characteristics of the interaction between interfacially adsorbed (partially inserted) α-helical, amphipathic peptides and the lipid bilayer substrate are studied using a molecular level theory of lipid chain packing in membranes. The peptides are modeled as “amphipathic cylinders” characterized by a well-defined polar angle. Assuming two-dimensional nematic order of the adsorbed peptides, the membrane perturbation free energy is evaluated using a cell-like model; the peptide axes are parallel to the membrane plane. The elastic and interfacial contributions to the perturbation free energy of the “peptide-dressed” membrane are evaluated as a function of: the peptide penetration depth into the bilayer's hydrophobic core, the membrane thickness, the polar angle, and the lipid/peptide ratio. The structural properties calculated include the shape and extent of the distorted (stretched and bent) lipid chains surrounding the adsorbed peptide, and their orientational (C-H) bond order parameter profiles. The changes in bond order parameters attendant upon peptide adsorption are in good agreement with magnetic resonance measurements. Also consistent with experiment, our model predicts that peptide adsorption results in membrane thinning. Our calculations reveal pronounced, membrane-mediated, attractive interactions between the adsorbed peptides, suggesting a possible mechanism for lateral aggregation of membrane-bound peptides. As a special case of interest, we have also investigated completely hydrophobic peptides, for which we find a strong energetic preference for the transmembrane (inserted) orientation over the horizontal (adsorbed) orientation. PMID:15189858

Orbital Injection of the SEDSAT Satellite: Tethered Systems Dynamics and Flight Data Analysis

NASA Technical Reports Server (NTRS)

Lorenzini, Enrico C.; Gullahorn, Gordon E.; Cosmo, Mario L.; Ruiz, Manuel; Pelaez, Jesus

1996-01-01

This report deals with the following topics which are all related to the orbital injection of the SEDSAT satellite: Dynamics and Stability of Tether Oscillations after the First Cut. The dynamics of the tether after the first cut (i.e., without the Shuttle attached to it) is investigated. The tether oscillations with the free end are analyzed in order to assess the stability of the rectilinear configuration in between the two tether cuts; analysis of Unstable Modes. The unstable modes that appear for high libration angles are further investigated in order to determine their occurrences and the possible transition from bound librations to rotations; Orbital Release Strategies for SEDSAT. A parametric analysis of the orbital decay rate of the SEDSAT satellite after the two tether cuts has been carried out as a function of the following free parameters: libration amplitude at the end of deployment, deviation angle from LV at the first cut, and orbital anomaly at the second cut. The values of these parameters that provide a minimum orbital decay rate of the satellite (after the two cuts) have been computed; and Dynamics and Control of SEDSAT. The deployment control law has been modified to cope with the new ejection velocity of the satellite from the Shuttle cargo bay. New reference profiles have been derived as well as new control parameters. Timing errors at the satellite release as a function of the variations of the initial conditions and the tension model parameters have been estimated for the modified control law.

Spatially uniform and nonuniform analyses of electroencephalographic dynamics,with application to the topography of the alpha rhythm

NASA Astrophysics Data System (ADS)

O'Connor, S. C.; Robinson, P. A.

2004-07-01

Corticothalamic dynamics are investigated using a model in which spatial nonuniformities are incorporated via the coupling of spatial eigenmodes. Comparison of spectra generated using the nonuniform analysis with those generated using a uniform one demonstrates that, for most frequencies, local activity is only weakly dependent on activity elsewhere in the cortex; however, dispersion of low-wave-number activity ensures that distant dynamics influence local dynamics at low frequencies (below approximately 2Hz ), and at the alpha frequency (approximately 10Hz ), where propagating signals are inherently weakly damped, and wavelengths are large. When certain model parameters have similar spatial profiles, as is expected from physiology, the low-frequency discrepancies tend to cancel, and the uniform analysis with local parameter values is an adequate approximation to the full nonuniform one across the whole spectrum, at least for large-scale nonuniformities. After comparing the uniform and nonuniform analyses, we consider one possible application of the nonuniform analysis: studying the phenomenon of occipital alpha dominance, whereby the alpha frequency and power are greater at the back of the head (occipitally) than at the front. In order to infer realistic nonuniformities in the model parameters, the uniform version of the model is first fitted to data recorded from 98 normal subjects in a waking, eyes-closed state. This yields a set of parameters at each of five electrode sites along the midline. The inferred parameter nonuniformities are consistent with anatomical and physiological constraints. Introducing these spatial profiles into the full nonuniform model then quantitatively reproduces observed site-dependent variations in the alpha power and frequency. The results confirm that the frequency shift is mainly due to a decrease in the corticothalamic propagation delay, but indicate that the delay nonuniformity cannot account for the observed occipital increase in alpha power; the occipital alpha dominance is due to decreased cortical gains and increased thalamic gains in occipital regions compared to frontal ones.

IUE observations of interstellar hydrogen and deuterium toward Alpha Centauri B

NASA Technical Reports Server (NTRS)

Landsman, W. B.; Murthy, J.; Henry, R. C.; Moos, H. W.; Linsky, J. L.

1986-01-01

A high dispersion profile is presented of the Lyman-alpha emission toward Alpha Cen B as recorded in two images taken with the IUE spacecraft. The spectra were examined with a three-parameter Gaussian or five-parameter solar-type profile to derive the intrinsic background stellar emission. Voight absorption profiles were calculated for the intervening H I and D I gas. A uniform, thermally broadened medium was assumed, with the calculations being based on the free stellar parameters of density, velocity dispersion and the bulk velocity of H I, and the density of D I. The use of a small aperture is shown to have been effective in eliminating geocoronal and interplanetary diffuse Ly-alpha contamination. The H I absorption profile toward Alpha Cen B is found to be equivalent to that toward Alpha Cen A, indicating that the H I profiles derived are essentially independent of stellar emission. Less success, however, was attained in obtaining any definitive D I profile, although an asymmetry in the blue and red wings of the Lyman-alpha emissions did show the presence of absorption by interstellar deuterium and allow setting a lower limit of 0.00001 for the D I/H I ratio.

Buoyancy effects on the radiative magneto Micropolar nanofluid flow with double stratification, activation energy and binary chemical reaction.

PubMed

Ramzan, M; Ullah, Naeem; Chung, Jae Dong; Lu, Dianchen; Farooq, Umer

2017-10-10

A mathematical model has been developed to examine the magneto hydrodynamic micropolar nanofluid flow with buoyancy effects. Flow analysis is carried out in the presence of nonlinear thermal radiation and dual stratification. The impact of binary chemical reaction with Arrhenius activation energy is also considered. Apposite transformations are engaged to transform nonlinear partial differential equations to differential equations with high nonlinearity. Resulting nonlinear system of differential equations is solved by differential solver method in Maple software which uses Runge-Kutta fourth and fifth order technique (RK45). To authenticate the obtained results, a comparison with the preceding article is also made. The evaluations are executed graphically for numerous prominent parameters versus velocity, micro rotation component, temperature, and concentration distributions. Tabulated numerical calculations of Nusselt and Sherwood numbers with respective well-argued discussions are also presented. Our findings illustrate that the angular velocity component declines for opposing buoyancy forces and enhances for aiding buoyancy forces by changing the micropolar parameter. It is also found that concentration profile increases for higher values of chemical reaction parameter, whereas it diminishes for growing values of solutal stratification parameter.

Impact of heating on sensory properties of French Protected Designation of Origin (PDO) blue cheeses. Relationships with physicochemical parameters.

PubMed

Bord, Cécile; Guerinon, Delphine; Lebecque, Annick

2016-07-01

The aim of this study was to measure the impact of heating on the sensory properties of blue-veined cheeses in order to characterise their sensory properties and to identify their specific sensory typology associated with physicochemical parameters. Sensory profiles were performed on a selection of Protected Designation of Origin (PDO) cheeses representing the four blue-veined cheese categories produced in the Massif Central (Fourme d'Ambert, Fourme de Montbrison, Bleu d'Auvergne and Bleu des Causses). At the same time, physicochemical parameters were measured in these cheeses. The relationship between these two sets of data was investigated. Four types of blue-veined cheeses displayed significantly different behaviour after heating and it is possible to discriminate these cheese categories through specific sensory attributes. Fourme d'Ambert and Bleu d'Auvergne exhibited useful culinary properties: they presented good meltability, stretchability and a weak oiling-off. However, basic tastes (salty, bitter and sour) are also sensory attributes which can distinguish heated blue cheeses. The relationship between the sensory and physicochemical data indicated a correlation suggesting that some of these sensory properties may be explained by certain physicochemical parameters of heated cheeses. © The Author(s) 2015.

Analysis of Flatness Deviations for Austenitic Stainless Steel Workpieces after Efficient Surface Machining

NASA Astrophysics Data System (ADS)

Nadolny, K.; Kapłonek, W.

2014-08-01

The following work is an analysis of flatness deviations of a workpiece made of X2CrNiMo17-12-2 austenitic stainless steel. The workpiece surface was shaped using efficient machining techniques (milling, grinding, and smoothing). After the machining was completed, all surfaces underwent stylus measurements in order to obtain surface flatness and roughness parameters. For this purpose the stylus profilometer Hommel-Tester T8000 by Hommelwerke with HommelMap software was used. The research results are presented in the form of 2D surface maps, 3D surface topographies with extracted single profiles, Abbott-Firestone curves, and graphical studies of the Sk parameters. The results of these experimental tests proved the possibility of a correlation between flatness and roughness parameters, as well as enabled an analysis of changes in these parameters from shaping and rough grinding to finished machining. The main novelty of this paper is comprehensive analysis of measurement results obtained during a three-step machining process of austenitic stainless steel. Simultaneous analysis of individual machining steps (milling, grinding, and smoothing) enabled a complementary assessment of the process of shaping the workpiece surface macro- and micro-geometry, giving special consideration to minimize the flatness deviations

A deterministic (non-stochastic) low frequency method for geoacoustic inversion.

PubMed

Tolstoy, A

2010-06-01

It is well known that multiple frequency sources are necessary for accurate geoacoustic inversion. This paper presents an inversion method which uses the low frequency (LF) spectrum only to estimate bottom properties even in the presence of expected errors in source location, phone depths, and ocean sound-speed profiles. Matched field processing (MFP) along a vertical array is used. The LF method first conducts an exhaustive search of the (five) parameter search space (sediment thickness, sound-speed at the top of the sediment layer, the sediment layer sound-speed gradient, the half-space sound-speed, and water depth) at 25 Hz and continues by retaining only the high MFP value parameter combinations. Next, frequency is slowly increased while again retaining only the high value combinations. At each stage of the process, only those parameter combinations which give high MFP values at all previous LF predictions are considered (an ever shrinking set). It is important to note that a complete search of each relevant parameter space seems to be necessary not only at multiple (sequential) frequencies but also at multiple ranges in order to eliminate sidelobes, i.e., false solutions. Even so, there are no mathematical guarantees that one final, unique "solution" will be found.

Evolutionary optimization with data collocation for reverse engineering of biological networks.

PubMed

Tsai, Kuan-Yao; Wang, Feng-Sheng

2005-04-01

Modern experimental biology is moving away from analyses of single elements to whole-organism measurements. Such measured time-course data contain a wealth of information about the structure and dynamic of the pathway or network. The dynamic modeling of the whole systems is formulated as a reverse problem that requires a well-suited mathematical model and a very efficient computational method to identify the model structure and parameters. Numerical integration for differential equations and finding global parameter values are still two major challenges in this field of the parameter estimation of nonlinear dynamic biological systems. We compare three techniques of parameter estimation for nonlinear dynamic biological systems. In the proposed scheme, the modified collocation method is applied to convert the differential equations to the system of algebraic equations. The observed time-course data are then substituted into the algebraic system equations to decouple system interactions in order to obtain the approximate model profiles. Hybrid differential evolution (HDE) with population size of five is able to find a global solution. The method is not only suited for parameter estimation but also can be applied for structure identification. The solution obtained by HDE is then used as the starting point for a local search method to yield the refined estimates.

3D Human cartilage surface characterization by optical coherence tomography.

PubMed

Brill, Nicolai; Riedel, Jörn; Schmitt, Robert; Tingart, Markus; Truhn, Daniel; Pufe, Thomas; Jahr, Holger; Nebelung, Sven

2015-10-07

Early diagnosis and treatment of cartilage degeneration is of high clinical interest. Loss of surface integrity is considered one of the earliest and most reliable signs of degeneration, but cannot currently be evaluated objectively. Optical Coherence Tomography (OCT) is an arthroscopically available light-based non-destructive real-time imaging technology that allows imaging at micrometre resolutions to millimetre depths. As OCT-based surface evaluation standards remain to be defined, the present study investigated the diagnostic potential of 3D surface profile parameters in the comprehensive evaluation of cartilage degeneration. To this end, 45 cartilage samples of different degenerative grades were obtained from total knee replacements (2 males, 10 females; mean age 63.8 years), cut to standard size and imaged using a spectral-domain OCT device (Thorlabs, Germany). 3D OCT datasets of 8  ×  8, 4  ×  4 and 1  ×  1 mm (width  ×  length) were obtained and pre-processed (image adjustments, morphological filtering). Subsequent automated surface identification algorithms were used to obtain the 3D primary profiles, which were then filtered and processed using established algorithms employing ISO standards. The 3D surface profile thus obtained was used to calculate a set of 21 3D surface profile parameters, i.e. height (e.g. Sa), functional (e.g. Sk), hybrid (e.g. Sdq) and segmentation-related parameters (e.g. Spd). Samples underwent reference histological assessment according to the Degenerative Joint Disease classification. Statistical analyses included calculation of Spearman's rho and assessment of inter-group differences using the Kruskal Wallis test. Overall, the majority of 3D surface profile parameters revealed significant degeneration-dependent differences and correlations with the exception of severe end-stage degeneration and were of distinct diagnostic value in the assessment of surface integrity. None of the 3D surface profile parameters investigated were capable of reliably differentiating healthy from early-degenerative cartilage, while scan area sizes considerably affected parameter values. In conclusion, cartilage surface integrity may be adequately assessed by 3D surface profile parameters, which should be used in combination for the comprehensive and thorough evaluation and overall improved diagnostic performance. OCT- and image-based surface assessment could become a valuable adjunct tool to standard arthroscopy.

3D Human cartilage surface characterization by optical coherence tomography

NASA Astrophysics Data System (ADS)

Brill, Nicolai; Riedel, Jörn; Schmitt, Robert; Tingart, Markus; Truhn, Daniel; Pufe, Thomas; Jahr, Holger; Nebelung, Sven

2015-10-01

Early diagnosis and treatment of cartilage degeneration is of high clinical interest. Loss of surface integrity is considered one of the earliest and most reliable signs of degeneration, but cannot currently be evaluated objectively. Optical Coherence Tomography (OCT) is an arthroscopically available light-based non-destructive real-time imaging technology that allows imaging at micrometre resolutions to millimetre depths. As OCT-based surface evaluation standards remain to be defined, the present study investigated the diagnostic potential of 3D surface profile parameters in the comprehensive evaluation of cartilage degeneration. To this end, 45 cartilage samples of different degenerative grades were obtained from total knee replacements (2 males, 10 females; mean age 63.8 years), cut to standard size and imaged using a spectral-domain OCT device (Thorlabs, Germany). 3D OCT datasets of 8  ×  8, 4  ×  4 and 1  ×  1 mm (width  ×  length) were obtained and pre-processed (image adjustments, morphological filtering). Subsequent automated surface identification algorithms were used to obtain the 3D primary profiles, which were then filtered and processed using established algorithms employing ISO standards. The 3D surface profile thus obtained was used to calculate a set of 21 3D surface profile parameters, i.e. height (e.g. Sa), functional (e.g. Sk), hybrid (e.g. Sdq) and segmentation-related parameters (e.g. Spd). Samples underwent reference histological assessment according to the Degenerative Joint Disease classification. Statistical analyses included calculation of Spearman’s rho and assessment of inter-group differences using the Kruskal Wallis test. Overall, the majority of 3D surface profile parameters revealed significant degeneration-dependent differences and correlations with the exception of severe end-stage degeneration and were of distinct diagnostic value in the assessment of surface integrity. None of the 3D surface profile parameters investigated were capable of reliably differentiating healthy from early-degenerative cartilage, while scan area sizes considerably affected parameter values. In conclusion, cartilage surface integrity may be adequately assessed by 3D surface profile parameters, which should be used in combination for the comprehensive and thorough evaluation and overall improved diagnostic performance. OCT- and image-based surface assessment could become a valuable adjunct tool to standard arthroscopy.

Advanced interactive display formats for terminal area traffic control

NASA Technical Reports Server (NTRS)

Grunwald, Arthur J.

1995-01-01

The basic design considerations for perspective Air Traffic Control displays are described. A software framework has been developed for manual viewing parameter setting (MVPS) in preparation for continued, ongoing developments on automated viewing parameter setting (AVPS) schemes. The MVPS system is based on indirect manipulation of the viewing parameters. Requests for changes in viewing parameter setting are entered manually by the operator by moving viewing parameter manipulation pointers on the screen. The motion of these pointers, which are an integral part of the 3-D scene, is limited to the boundaries of screen. This arrangement has been chosen, in order to preserve the correspondence between the new and the old viewing parameter setting, a feature which contributes to preventing spatial disorientation of the operator. For all viewing operations, e.g. rotation, translation and ranging, the actual change is executed automatically by the system, through gradual transitions with an exponentially damped, sinusoidal velocity profile, in this work referred to as 'slewing' motions. The slewing functions, which eliminate discontinuities in the viewing parameter changes, are designed primarily for enhancing the operator's impression that he, or she, is dealing with an actually existing physical system, rather than an abstract computer generated scene. Current, ongoing efforts deal with the development of automated viewing parameter setting schemes. These schemes employ an optimization strategy, aimed at identifying the best possible vantage point, from which the Air Traffic Control scene can be viewed, for a given traffic situation.

[Spatial distribution and ecological significance of heavy metals in soils from Chatian mercury mining deposit, western Hunan province].

PubMed

Sun, Hong-Fei; Li, Yong-Hu; Ji, Yan-Fang; Yang, Lin-Sheng; Wang, Wu-Yi

2009-04-15

Ores, waste tailings and slag, together with three typical soil profiles (natural soil profiles far from mine entrance and near mine entrance, soil profile under slag) in Chatian mercury mining deposit (CMD), western Hunan province were sampled and their concentrations of mercury (Hg), arsenic (As), lead (Pb), cadmium (Cd), zinc (Zn) were determined by HG-ICP-AES and ICP-MS. Enrichment factor and correlation analysis were taken to investigate the origins, distribution and migration of Hg, as well as other heavy metals in the CMD. The results show that Hg is enriched in the bottom of the soil profile far from mine entrance but accumulated in the surface of soil profiles near mine entrance and under slag. The soil profiles near mine entrance and under slag are both contaminated by Hg, while the latter is contaminated more heavily. In the soil profile under slag, Hg concentration in the surface soil, Hg average concentration in the total profile, and the leaching depth of soil Hg are 640 microg x g(-1), (76.74 +/- 171.71) microg x g(-1), and more than 100 cm, respectively; while 6.5 microg x g(-1), (2.74 +/- 1.90) microg x g(-1), and 40 cm, respectively, are found in the soil profile near mine entrance. Soil in the mercury mine area is also polluted by Cd, As, Pb, Zn besides metallogenic element Hg, among which Cd pollution is relatively heavier than others. The mobility of the studied heavy metals in soil follows the order as Hg > Cd > As > Zn approximately equal to Pb. The leaching depth of the heavy metals is influenced by total concentration in the surface soil and soil physico-chemical parameters. The origins, distribution and migration of heavy metals in soil profile in the mining area are related to primary geological environment, and strongly influenced by human mining activities.

A summary report on the search for current technologies and developers to develop depth profiling/physical parameter end effectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Q.H.

1994-09-12

This report documents the search strategies and results for available technologies and developers to develop tank waste depth profiling/physical parameter sensors. Sources searched include worldwide research reports, technical papers, journals, private industries, and work at Westinghouse Hanford Company (WHC) at Richland site. Tank waste physical parameters of interest are: abrasiveness, compressive strength, corrosiveness, density, pH, particle size/shape, porosity, radiation, settling velocity, shear strength, shear wave velocity, tensile strength, temperature, viscosity, and viscoelasticity. A list of related articles or sources for each physical parameters is provided.

MO-FG-202-03: Efficient Data Collection of Continuous 2D and Discrete Relative Dosimetric Data for Annual LINAC QA Using TrueBeam Developer Mode and a 1D Scanning Tank

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knutson, N; Schmidt, M; University of Rhode Island, Kingston, RI

2016-06-15

Purpose: To develop a method to exploit real-time dynamic machine and couch parameter control during linear accelerator (LINAC) beam delivery to facilitate efficient performance of TG-142 suggested, Annual LINAC QA tests. Methods: Varian’s TrueBeam Developer Mode (Varian Medical Systems, Palo Alto, CA) facilitates control of Varian’s TrueBeam LINAC via instructions provided in Extensible Markup Language (XML) files. This allows machine and couch parameters to be varied dynamically, in real-time, during beam delivery. Custom XML files were created to allow for the collection of (1) continuous Tissue Maximum Ratios (TMRs), (2) beam profiles, and (3) continuous output factors using a 1D-scanningmore » tank. TMRs were acquired by orienting an ionization chamber (IC) at isocenter (depth=25cm) and synchronizing a depth scan towards the water surface while lowering the couch at 1mm/s. For beam profiles, the couch was driven laterally and longitudinally while logging IC electrometer readings. Output factors (OFs) where collected by continually varying field sizes (4×4 to 30×30-cm{sup 2}) at a constant speed of 6.66 mm/s. To validate measurements, comparisons were made to data collected using traditional methods (e.g. 1D or 3D tank). Results: All data collecting using the proposed methods agreed with traditionally collected data (TMRs within 1%, OFs within 0.5% and beam profile agreement within 1% / 1mm) while taking less time to collect (factor of approximately 1/10) and with a finer sample resolution. Conclusion: TrueBeam developer mode facilitates collection of continuous data with the same accuracy as traditionally collected data with a finer resolution in less time. Results demonstrate an order of magnitude increase in sampled resolution and an order of magnitude reduction in collection time compared to traditional acquisition methods (e.g. 3D scanning tank). We are currently extending this approach to perform other TG-142 tasks.« less

Main features of anthropogenic inner-urban soils in Szeged, Hungary

NASA Astrophysics Data System (ADS)

Puskás, Irén.; Farsang, Andrea

2010-05-01

At the beginning of the 21st century, due to the intensive urbanization it is necessary to gather more and more information on altered physical, chemical and biological parameters of urban soils in order to ensure their suitable management and protection for appropriate living conditions. Nowadays, these measures are very relevant since negative environmental effects can modify the soil forming factors in cities. Szeged, the 4th largest city of Hungary, proved to be an ideal sampling area for the research of urban soils since its original surface has been altered by intensive anthropogenic activities. The main objectives of my research are the investigation, description and evaluation of the altered soils in Szeged. For the physical and chemical analysis (humus, nitrogen, carbonate content, heavy metals, pH, artefacts etc.) of soils 124 samples were taken from the horizons of 25 profiles in Szeged and its peripherals (as control samples). The profiles were sampled at sites affected by different extent of artificial infill according to infill maps (1. profiles fully made up of infill; 2. so-called mixed profiles consisting of considerable amount of infill material and buried soil horizons; 3. natural profiles located in the peripherals of the city). With the help of the above-mentioned parameters, the studied soils of Szeged were assigned into the classification system of WRB(2006), which classifies the soils of urban and industrial areas as an individual soil group (under the term Technosols) for the first time. In accordance with the WRB(2006) nomenclature three main soil types can be identified in Szeged with respect to the degree of human influence: profiles slightly influenced, strongly modified, completely altered by human activities. During this poster, we present the peculiarities of typical urban profiles strongly and completely altered by human influence. Most profiles were placed into the group of Technosols due to the considerable transformation of their diagnostic properties (e.g. coverage by artificial objects, intensive compaction, horizontal and vertical variability, abrupt colour and textural changes usually high amount of artefacts, irregular fluctuation of diagnostic properties along the profiles, anthropogenic parent material, high pH and carbonate content, poor humus quality, mainly sand, sandy loam texture etc.). Transformations were best reflected by suffixes such as Ekranic, Urbic, Linic. Among the suffix qualifiers Calcaric, Ruptic, Densic and Arenic were used the most frequently. Furthermore, we found that some of the studied profiles were not situated in the city centre. Consequently, the location of these profiles in the city centre is not necessary since local influences can overwhelm the effect of artificial infill. Considering all the profiles, two of them in city centre can be consider to be the most anthropogenic: profile No. 11 [Ekranic Technosol (Ruptic, Toxic, Endoclayic)] and profile No. 22 [Urbic Technosol (Calcaric, Ruptic, Densic, Arenic)]. It can be claimed that profile No. 11 with "technic hard rock" has the least chance to experience pedogenetic processes since the horizons are covered by thick, surface artificial object, and isolated from the outside world. However, in case of profile No. 22 with dense vegetation and without surface artificial object, the high amount of artefact inhibits pedogenesis.

Ensemble assimilation of ARGO temperature profile, sea surface temperature, and altimetric satellite data into an eddy permitting primitive equation model of the North Atlantic Ocean

NASA Astrophysics Data System (ADS)

Yan, Y.; Barth, A.; Beckers, J. M.; Candille, G.; Brankart, J. M.; Brasseur, P.

2015-07-01

Sea surface height, sea surface temperature, and temperature profiles at depth collected between January and December 2005 are assimilated into a realistic eddy permitting primitive equation model of the North Atlantic Ocean using the Ensemble Kalman Filter. Sixty ensemble members are generated by adding realistic noise to the forcing parameters related to the temperature. The ensemble is diagnosed and validated by comparison between the ensemble spread and the model/observation difference, as well as by rank histogram before the assimilation experiments. An incremental analysis update scheme is applied in order to reduce spurious oscillations due to the model state correction. The results of the assimilation are assessed according to both deterministic and probabilistic metrics with independent/semiindependent observations. For deterministic validation, the ensemble means, together with the ensemble spreads are compared to the observations, in order to diagnose the ensemble distribution properties in a deterministic way. For probabilistic validation, the continuous ranked probability score (CRPS) is used to evaluate the ensemble forecast system according to reliability and resolution. The reliability is further decomposed into bias and dispersion by the reduced centered random variable (RCRV) score in order to investigate the reliability properties of the ensemble forecast system. The improvement of the assimilation is demonstrated using these validation metrics. Finally, the deterministic validation and the probabilistic validation are analyzed jointly. The consistency and complementarity between both validations are highlighted.

IMPROVED SEARCH OF PRINCIPAL COMPONENT ANALYSIS DATABASES FOR SPECTRO-POLARIMETRIC INVERSION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casini, R.; Lites, B. W.; Ramos, A. Asensio

2013-08-20

We describe a simple technique for the acceleration of spectro-polarimetric inversions based on principal component analysis (PCA) of Stokes profiles. This technique involves the indexing of the database models based on the sign of the projections (PCA coefficients) of the first few relevant orders of principal components of the four Stokes parameters. In this way, each model in the database can be attributed a distinctive binary number of 2{sup 4n} bits, where n is the number of PCA orders used for the indexing. Each of these binary numbers (indices) identifies a group of ''compatible'' models for the inversion of amore » given set of observed Stokes profiles sharing the same index. The complete set of the binary numbers so constructed evidently determines a partition of the database. The search of the database for the PCA inversion of spectro-polarimetric data can profit greatly from this indexing. In practical cases it becomes possible to approach the ideal acceleration factor of 2{sup 4n} as compared to the systematic search of a non-indexed database for a traditional PCA inversion. This indexing method relies on the existence of a physical meaning in the sign of the PCA coefficients of a model. For this reason, the presence of model ambiguities and of spectro-polarimetric noise in the observations limits in practice the number n of relevant PCA orders that can be used for the indexing.« less

Photospheres of hot stars. IV - Spectral type O4

NASA Technical Reports Server (NTRS)

Bohannan, Bruce; Abbott, David C.; Voels, Stephen A.; Hummer, David G.

1990-01-01

The basic stellar parameters of a supergiant (Zeta Pup) and two main-sequence stars, 9 Sgr and HD 46223, at spectral class O4 are determined using line profile analysis. The stellar parameters are determined by comparing high signal-to-noise hydrogen and helium line profiles with those from stellar atmosphere models which include the effect of radiation scattered back onto the photosphere from an overlying stellar wind, an effect referred to as wind blanketing. At spectral class O4, the inclusion of wind-blanketing in the model atmosphere reduces the effective temperature by an average of 10 percent. This shift in effective temperature is also reflected by shifts in several other stellar parameters relative to previous O4 spectral-type calibrations. It is also shown through the analysis of the two O4 V stars that scatter in spectral type calibrations is introduced by assuming that the observed line profile reflects the photospheric stellar parameters.

Improved depth profiling with slow positrons of ion implantation-induced damage in silicon

NASA Astrophysics Data System (ADS)

Fujinami, M.; Miyagoe, T.; Sawada, T.; Akahane, T.

2003-10-01

Variable-energy positron annihilation spectroscopy (VEPAS) has been extensively applied to study defects in near-surface regions and buried interfaces, but there is an inherent limit for depth resolution due to broadening of the positron implantation profile. In order to overcome this limit and obtain optimum depth resolution, iterative chemical etching of the sample surface and VEPAS measurement are employed. This etch-and-measure technique is described in detail and the capabilities are illustrated by investigating the depth profile of defects in Si after B and P implantations with 2×1014/cm2 at 100 keV followed by annealing. Defect tails can be accurately examined and the extracted defect profile is proven to extend beyond the implanted ion range predicted by the Monte Carlo code TRIM. This behavior is more remarkable for P ion implantation than B, and the mass difference of the implanted ions is strongly related to it. No significant difference is recognized in the annealing behavior between B and P implantations. After annealing at 300 °C, the defect profile is hardly changed, but the ratio of the characteristic Doppler broadening, S, a parameter for defects, to that for the bulk Si rises by 0.01, indicating that divacancies, V2, are transformed into V4. Annealing at more than 500 °C causes diffusion of the defects toward the surface and positron traps are annealed out at 800 °C. It is proved that this resolution-enhanced VEPAS can eliminate some discrepancies in defect profiles extracted by conventional means.

The relative importance of decomposition and transport mechanisms in accounting for soil organic carbon profiles

NASA Astrophysics Data System (ADS)

Guenet, B.; Eglin, T.; Vasilyeva, N.; Peylin, P.; Ciais, P.; Chenu, C.

2013-04-01

Soil is the major terrestrial reservoir of carbon and a substantial part of this carbon is stored in deep layers, typically deeper than 50 cm below the surface. Several studies underlined the quantitative importance of this deep soil organic carbon (SOC) pool and models are needed to better understand this stock and its evolution under climate and land-uses changes. In this study, we tested and compared three simple theoretical models of vertical transport for SOC against SOC profiles measurements from a long-term bare fallow experiment carried out by the Central-Chernozem State Natural Biosphere Reserve in the Kursk Region of Russia. The transport schemes tested are diffusion, advection and both diffusion and advection. They are coupled to three different formulations of soil carbon decomposition kinetics. The first formulation is a first order kinetics widely used in global SOC decomposition models; the second one, so-called "priming" model, links SOC decomposition rate to the amount of fresh organic matter, representing the substrate interactions. The last one is also a first order kinetics, but SOC is split into two pools. Field data are from a set of three bare fallow plots where soil received no input during the past 20, 26 and 58 yr, respectively. Parameters of the models were optimised using a Bayesian method. The best results are obtained when SOC decomposition is assumed to be controlled by fresh organic matter (i.e., the priming model). In comparison to the first-order kinetic model, the priming model reduces the overestimation in the deep layers. We also observed that the transport scheme that improved the fit with the data depended on the soil carbon mineralisation formulation chosen. When soil carbon decomposition was modelled to depend on the fresh organic matter amount, the transport mechanism which improved best the fit to the SOC profile data was the model representing both advection and diffusion. Interestingly, the older the bare fallow is, the lesser the need for diffusion is, suggesting that stabilised carbon may not be transported within the profile by the same mechanisms than more labile carbon.

Rational selection of experimental readout and intervention sites for reducing uncertainties in computational model predictions.

PubMed

Flassig, Robert J; Migal, Iryna; der Zalm, Esther van; Rihko-Struckmann, Liisa; Sundmacher, Kai

2015-01-16

Understanding the dynamics of biological processes can substantially be supported by computational models in the form of nonlinear ordinary differential equations (ODE). Typically, this model class contains many unknown parameters, which are estimated from inadequate and noisy data. Depending on the ODE structure, predictions based on unmeasured states and associated parameters are highly uncertain, even undetermined. For given data, profile likelihood analysis has been proven to be one of the most practically relevant approaches for analyzing the identifiability of an ODE structure, and thus model predictions. In case of highly uncertain or non-identifiable parameters, rational experimental design based on various approaches has shown to significantly reduce parameter uncertainties with minimal amount of effort. In this work we illustrate how to use profile likelihood samples for quantifying the individual contribution of parameter uncertainty to prediction uncertainty. For the uncertainty quantification we introduce the profile likelihood sensitivity (PLS) index. Additionally, for the case of several uncertain parameters, we introduce the PLS entropy to quantify individual contributions to the overall prediction uncertainty. We show how to use these two criteria as an experimental design objective for selecting new, informative readouts in combination with intervention site identification. The characteristics of the proposed multi-criterion objective are illustrated with an in silico example. We further illustrate how an existing practically non-identifiable model for the chlorophyll fluorescence induction in a photosynthetic organism, D. salina, can be rendered identifiable by additional experiments with new readouts. Having data and profile likelihood samples at hand, the here proposed uncertainty quantification based on prediction samples from the profile likelihood provides a simple way for determining individual contributions of parameter uncertainties to uncertainties in model predictions. The uncertainty quantification of specific model predictions allows identifying regions, where model predictions have to be considered with care. Such uncertain regions can be used for a rational experimental design to render initially highly uncertain model predictions into certainty. Finally, our uncertainty quantification directly accounts for parameter interdependencies and parameter sensitivities of the specific prediction.

Bayesian identification of acoustic impedance in treated ducts.

PubMed

Buot de l'Épine, Y; Chazot, J-D; Ville, J-M

2015-07-01

The noise reduction of a liner placed in the nacelle of a turbofan engine is still difficult to predict due to the lack of knowledge of its acoustic impedance that depends on grazing flow profile, mode order, and sound pressure level. An eduction method, based on a Bayesian approach, is presented here to adjust an impedance model of the liner from sound pressures measured in a rectangular treated duct under multimodal propagation and flow. The cost function is regularized with prior information provided by Guess's [J. Sound Vib. 40, 119-137 (1975)] impedance of a perforated plate. The multi-parameter optimization is achieved with an Evolutionary-Markov-Chain-Monte-Carlo algorithm.

Stellar Populations in Elliptical Galaxies

NASA Astrophysics Data System (ADS)

Angeletti, Lucio; Giannone, Pietro

The R1/n law for the radial surface brightness of elliptical galaxies and the "Best Accretion Model" together with the "Concentration Model" have been combined in order to determine the mass and dynamical structure of largely-populated star systems. Families of models depending on four parameters have been used to fit the observed surface radial profiles of some spectro-photometric indices of a sample of eleven galaxies. We present the best agreements of the spectral index Mg2 with observations for three selected galaxies representative of the full sample. For them we have also computed the spatial distributions of the metal abundances, which are essential to achieve a population synthesis.

Navigating ligand protein binding free energy landscapes: universality and diversity of protein folding and molecular recognition mechanisms

NASA Astrophysics Data System (ADS)

Verkhivker, Gennady M.; Rejto, Paul A.; Bouzida, Djamal; Arthurs, Sandra; Colson, Anthony B.; Freer, Stephan T.; Gehlhaar, Daniel K.; Larson, Veda; Luty, Brock A.; Marrone, Tami; Rose, Peter W.

2001-03-01

Thermodynamic and kinetic aspects of ligand-protein binding are studied for the methotrexate-dihydrofolate reductase system from the binding free energy profile constructed as a function of the order parameter. Thermodynamic stability of the native complex and a cooperative transition to the unique native structure suggest the nucleation kinetic mechanism at the equilibrium transition temperature. Structural properties of the transition state ensemble and the ensemble of nucleation conformations are determined by kinetic simulations of the transmission coefficient and ligand-protein association pathways. Structural analysis of the transition states and the nucleation conformations reconciles different views on the nucleation mechanism in protein folding.

Excitation efficiency of an optical fiber core source

NASA Technical Reports Server (NTRS)

Egalon, Claudio O.; Rogowski, Robert S.; Tai, Alan C.

1992-01-01

The exact field solution of a step-index profile fiber is used to determine the excitation efficiency of a distribution of sources in the core of an optical fiber. Previous results of a thin-film cladding source distribution to its core source counterpart are used for comparison. The behavior of power efficiency with the fiber parameters is examined and found to be similar to the behavior exhibited by cladding sources. It is also found that a core-source fiber is two orders of magnitude more efficient than a fiber with a bulk distribution of cladding sources. This result agrees qualitatively with previous ones obtained experimentally.

The projected gravitational potential of the galaxy cluster MACS J1206 derived from galaxy kinematics

NASA Astrophysics Data System (ADS)

Stock, Dennis; Meyer, Sven; Sarli, Eleonora; Bartelmann, Matthias; Balestra, Italo; Grillo, Claudio; Koekemoer, Anton; Mercurio, Amata; Nonino, Mario; Rosati, Piero

2015-12-01

We reconstruct the radial profile of the projected gravitational potential of the galaxy cluster MACS J1206 from 592 spectroscopic measurements of velocities of cluster members. To accomplish this, we use a method we have developed recently based on the Richardson-Lucy deprojection algorithm and an inversion of the spherically-symmetric Jeans equation. We find that, within the uncertainties, our reconstruction agrees very well with a potential reconstruction from weak and strong gravitational lensing as well as with a potential obtained from X-ray measurements. In addition, our reconstruction is in good agreement with several common analytic profiles of the lensing potential. Varying the anisotropy parameter in the Jeans equation, we find that isotropy parameters, which are either small, β ≲ 0.2, or decrease with radius, yield potential profiles that strongly disagree with that obtained from gravitational lensing. We achieve the best agreement between our potential profile and the profile from gravitational lensing if the anisotropy parameter rises steeply to β ≈ 0.6 within ≈ 0.5 Mpc and stays constant further out.

Optimization of CO2 laser cutting parameters on Austenitic type Stainless steel sheet

NASA Astrophysics Data System (ADS)

Parthiban, A.; Sathish, S.; Chandrasekaran, M.; Ravikumar, R.

2017-03-01

Thin AISI 316L stainless steel sheet widely used in sheet metal processing industries for specific applications. CO2 laser cutting is one of the most popular sheet metal cutting processes for cutting of sheets in different profile. In present work various cutting parameters such as laser power (2000 watts-4000 watts), cutting speed (3500mm/min - 5500 mm/min) and assist gas pressure (0.7 Mpa-0.9Mpa) for cutting of AISI 316L 2mm thickness stainless sheet. This experimentation was conducted based on Box-Behenken design. The aim of this work is to develop a mathematical model kerf width for straight and curved profile through response surface methodology. The developed mathematical models for straight and curved profile have been compared. The Quadratic models have the best agreement with experimental data, and also the shape of the profile a substantial role in achieving to minimize the kerf width. Finally the numerical optimization technique has been used to find out best optimum laser cutting parameter for both straight and curved profile cut.

Degradation rates of alachlor, atrazine and bentazone in the profiles of Polish Luvisols

NASA Astrophysics Data System (ADS)

Paszko, Tadeusz; Muszyński, Paweł

2017-07-01

The degradation rates of three herbicides (alachlor, atrazine, and bentazone) were examined according to OECD Guideline 307 in three profiles of grey-brown podzolic soil (Luvisol) in a laboratory experiment. The aim of the experiment was to determine herbicide degradation parameters and their relationships with soil properties. Degradation processes were effectively described by a first-order model. However, in some cases, the best results were produced by bi-phasic kinetics (hockey-stick and bi-exponential model). The degradation rates of the tested herbicides at 25°C and 40% maximum water holding capacity, established based on half-life values in the Ap horizon, increased in the following order: atrazine (32.6-42.8 days) < bentazone (3.4-16.6 days < alachlor (4.4-5.7 days). The correlation analysis and the Principal Component Analysis revealed significant positive correlations between the herbicide degradation rates and the organic matter content of soils. The depth-dependent degradation factors obtained for topsoil and two subsoil horizons (1: 0.42: 0.11 - based on average values, and 1: 0.31: 0.12 - based on median values) reflect the degradation abilities of Polish Luvisols. The values noted are soil-specific; therefore, they can also be applied to other pesticides in Polish Luvisols.

Nanoscale β-nuclear magnetic resonance depth imaging of topological insulators

PubMed Central

Koumoulis, Dimitrios; Morris, Gerald D.; He, Liang; Kou, Xufeng; King, Danny; Wang, Dong; Hossain, Masrur D.; Wang, Kang L.; Fiete, Gregory A.; Kanatzidis, Mercouri G.; Bouchard, Louis-S.

2015-01-01

Considerable evidence suggests that variations in the properties of topological insulators (TIs) at the nanoscale and at interfaces can strongly affect the physics of topological materials. Therefore, a detailed understanding of surface states and interface coupling is crucial to the search for and applications of new topological phases of matter. Currently, no methods can provide depth profiling near surfaces or at interfaces of topologically inequivalent materials. Such a method could advance the study of interactions. Herein, we present a noninvasive depth-profiling technique based on β-detected NMR (β-NMR) spectroscopy of radioactive 8Li+ ions that can provide “one-dimensional imaging” in films of fixed thickness and generates nanoscale views of the electronic wavefunctions and magnetic order at topological surfaces and interfaces. By mapping the 8Li nuclear resonance near the surface and 10-nm deep into the bulk of pure and Cr-doped bismuth antimony telluride films, we provide signatures related to the TI properties and their topological nontrivial characteristics that affect the electron–nuclear hyperfine field, the metallic shift, and magnetic order. These nanoscale variations in β-NMR parameters reflect the unconventional properties of the topological materials under study, and understanding the role of heterogeneities is expected to lead to the discovery of novel phenomena involving quantum materials. PMID:26124141

O-regime dynamics and modeling in Tore Supra

NASA Astrophysics Data System (ADS)

Turco, F.; Giruzzi, G.; Imbeaux, F.; Udintsev, V. S.; Artaud, J. F.; Barana, O.; Dumont, R.; Mazon, D.; Ségui, J.-L.

2009-06-01

The regime of nonlinear temperature oscillations (O-regime), characteristic of noninductive discharges on Tore Supra [Équipe Tore Supra, Proceedings of the 12th International Conference on Plasma Physics and Controlled Nuclear Fusion Research, Nice, France, 1988 (International Atomic Energy Agency, Vienna, 1989), Vol. 1, p. 9], is investigated in its triggering and suppressing mechanism. This regime can be described by two nonlinearly coupled equations for the current density j(r ) and the electron temperature Te(r) where the equation coefficients are functions of j and Te themselves. Both the integrated modeling code CRONOS [V. Basiuk et al., Nucl. Fusion 43, 822 (2003)] and a two-patch predator-prey system with diffusion and noise have been used and results have been compared to the experimental observations of the O-regime. A database of discharges is analyzed which features monotonic, flat, and reversed safety factor (q) profiles in order to characterize the action of external actuators on the regime dynamics with the widest generality. Electron cyclotron current drive and neutral beam injections have been used in order to induce localized perturbations in the total current profile j(r ) as well as to change the plasma confinement conditions in the central region. Magnetic shear perturbations and modifications of the heat transport turn out to be the central parameters governing the dynamics of the O-regime.

MHD Jeffrey nanofluid past a stretching sheet with viscous dissipation effect

NASA Astrophysics Data System (ADS)

Zokri, S. M.; Arifin, N. S.; Salleh, M. Z.; Kasim, A. R. M.; Mohammad, N. F.; Yusoff, W. N. S. W.

2017-09-01

This study investigates the influence of viscous dissipation on magnetohydrodynamic (MHD) flow of Jeffrey nanofluid over a stretching sheet with convective boundary conditions. The nonlinear partial differential equations are reduced into the nonlinear ordinary differential equations by utilizing the similarity transformation variables. The Runge-Kutta Fehlberg method is used to solve the problem numerically. The numerical solutions obtained are presented graphically for several dimensionless parameters such as Brownian motion, Lewis number and Eckert number on the specified temperature and concentration profiles. It is noted that the temperature profile is accelerated due to increasing values of Brownian motion parameter and Eckert number. In contrast, both the Brownian motion parameter and Lewis number have caused the deceleration in the concentration profiles.

Effect of X-ray Line Spectra Profile Fitting with Pearson VII, Pseudo-Voigt and Generalized Fermi Functions on Asphalt Binder Aromaticity and Crystallite Parameters

NASA Astrophysics Data System (ADS)

Gebresellasie, K.; Shirokoff, J.; Lewis, J. C.

2012-12-01

X-ray line spectra profile fitting using Pearson VII, pseudo-Voigt and generalized Fermi functions was performed on asphalt binders prior to the calculation of aromaticity and crystallite size parameters. The effects of these functions on the results are presented and discussed in terms of the peak profile fit parameters, the uncertainties in calculated values that can arise owing to peak shape, peak features in the pattern and crystallite size according to the asphalt models (Yen, modified Yen or Yen-Mullins) and theories. Interpretation of these results is important in terms of evaluating the performance of asphalt binders widely used in the application of transportation systems (roads, highways, airports).

Optical property retrievals of subvisual cirrus clouds from OSIRIS limb-scatter measurements

NASA Astrophysics Data System (ADS)

Wiensz, J. T.; Degenstein, D. A.; Lloyd, N. D.; Bourassa, A. E.

2012-08-01

We present a technique for retrieving the optical properties of subvisual cirrus clouds detected by OSIRIS, a limb-viewing satellite instrument that measures scattered radiances from the UV to the near-IR. The measurement set is composed of a ratio of limb radiance profiles at two wavelengths that indicates the presence of cloud-scattering regions. Optical properties from an in-situ database are used to simulate scattering by cloud-particles. With appropriate configurations discussed in this paper, the SASKTRAN successive-orders of scatter radiative transfer model is able to simulate accurately the in-cloud radiances from OSIRIS. Configured in this way, the model is used with a multiplicative algebraic reconstruction technique (MART) to retrieve the cloud extinction profile for an assumed effective cloud particle size. The sensitivity of these retrievals to key auxiliary model parameters is shown, and it is demonstrated that the retrieved extinction profile models accurately the measured in-cloud radiances from OSIRIS. Since OSIRIS has an 11-yr record of subvisual cirrus cloud detections, the work described in this manuscript provides a very useful method for providing a long-term global record of the properties of these clouds.

Gyrokinetic simulations of particle transport in pellet fuelled JET discharges

NASA Astrophysics Data System (ADS)

Tegnered, D.; Oberparleiter, M.; Nordman, H.; Strand, P.; Garzotti, L.; Lupelli, I.; Roach, C. M.; Romanelli, M.; Valovič, M.; Contributors, JET

2017-10-01

Pellet injection is a likely fuelling method of reactor grade plasmas. When the pellet ablates, it will transiently perturb the density and temperature profiles of the plasma. This will in turn change dimensionless parameters such as a/{L}n,a/{L}T and plasma β. The microstability properties of the plasma then changes which influences the transport of heat and particles. In this paper, gyrokinetic simulations of a JET L-mode pellet fuelled discharge are performed. The ion temperature gradient/trapped electron mode turbulence is compared at the time point when the effect from the pellet is the most pronounced with a hollow density profile and when the profiles have relaxed again. Linear and nonlinear simulations are performed using the gyrokinetic code GENE including electromagnetic effects and collisions in a realistic geometry in local mode. Furthermore, global nonlinear simulations are performed in order to assess any nonlocal effects. It is found that the positive density gradient has a stabilizing effect that is partly counteracted by the increased temperature gradient in the this region. The effective diffusion coefficients are reduced in the positive density region region compared to the intra pellet time point. No major effect on the turbulent transport due to nonlocal effects are observed.

On the Origin of the Wind Variability of 55 Cyg

NASA Astrophysics Data System (ADS)

Haucke, M.; Kraus, M.; Venero, R. O. J.; Tomić, S.; Cidale, L. S.; Nickeler, D. H.; Curé, M.

2014-10-01

The early B-type supergiant 55 Cygni exhibits pronounced night-to-night variations in its Hα P-Cygni line profile, probably related to a strong variable stellar wind. In this work we studied a sample of spectroscopic observations, taken at the Observatory of Ondřejov (Czech Republic), in order to analyze the variations in the stellar and wind parameters. The observations were modeled using FASTWIND code (Santolaya-Rey, Puls & Herrero 1997, A&A 323, 488-512). Although we were not able to find an exact period from the Hα line profile variations, the same pattern (shape and intensity) seems to have a cyclic behaviour of about 17 days. The values for the wind and stellar parameters suggest changes of the mass loss rate by a factor of three during a cycle of variability. On the other hand, Kraus et al. (Precision Asteroseismology Proceedings, IAU Symposium 301, 2014) found that the HeI λ 6678 photospheric absorption line presents a 1.09 day period, which could be superimposed over a longer period. From the analysis of our theoretical parameters we found that a gravitational mode of pulsation could not be the only agent responsible for the observed variations. As the stars evolving from the main sequence to the red supergiant stage (RSG) have different pulsation properties than those evolving back to the blue supergiant region (Saio, Georgy & Meynet, 2013, MNRAS, 433, 1246), we conclude that 55 Cygni could be in a post-RSG phase with multiperiodic pulsation modes. The variable mass loss could be attributed to the coupling of the oscillation modes.

Does an alteration of dialyzer design and geometry affect biocompatibility parameters?

PubMed

Opatrný, Karel; Krouzzecký, Ales; Polanská, Kamila; Mares, Jan; Tomsů, Martina; Bowry, Sudhir K; Vienken, Jörg

2006-04-01

The aim of the study was to assess the biocompatibility profile of a newly developed high-flux polysulfone dialyzer type (FX-class dialyzer). The new class of dialyzers incorporates a number of novel design features (including a new membrane) that have been developed specifically in order to enhance the removal of small- and middle-size molecules. The new FX dialyzer series was compared with the classical routinely used high-flux polysulfone F series of dialyzers. In an open prospective, randomized, crossover clinical study, concentrations of the C5a complement component, and leukocyte count in blood and various thrombogenicity parameters were evaluated before, and at 15 and 60 min of hemodialysis at both dialyzer inlet and outlet in 9 long-term hemodialysis patients using the FX60S dialyzers and, after crossover, the classical F60S, while in another 9 patients, the evaluation was made with the dialyzers used in reverse order. The comparison of dialyzers based on evaluation of the group including all procedures with the FX60S and the group including procedures with the F60S did not reveal significant differences in platelet count, activated partial thromboplastin times, plasma heparin levels, platelet factor-4, D-dimer, C5a, and leukocyte count at any point of the collecting period. Both dialyzer types showed a significant increase in the plasma levels of the thrombin-antithrombin III complexes; however, the measured levels were only slightly elevated compared with the upper end of the normal range. Biocompatibility parameters reflecting the behavior of platelets, fibrinolysis, complement activation, and leukopenia do not differ during dialysis with either the FX60S or the F60S despite their large differences in design and geometry features. Although coagulation activation, as evaluated by one of the parameters used, was slightly higher with the FX60S, it was still within the range seen with other highly biocompatible dialyzers and therefore is not indicative of any appreciable activation of the coagulation system. Thus, the incorporation of various performance-enhancing design features into the new FX class of dialyzers does not result in a deterioration of their biocompatibility profile, which is comparable to that of the classical F series of dialyzers.

Structural domains and conformational changes in nuclear chromatin: a quantitative thermodynamic approach by differential scanning calorimetry.

PubMed

Balbi, C; Abelmoschi, M L; Gogioso, L; Parodi, S; Barboro, P; Cavazza, B; Patrone, E

1989-04-18

A good deal of information on the thermodynamic properties of chromatin was derived in the last few years from optical melting experiments. The structural domains of the polynucleosomal chain, the linker, and the core particle denature as independent units. The differential scanning calorimetry profile of isolated chromatin is made up of three endotherms, at approximately 74, 90, and 107 degrees C, having an almost Gaussian shape. Previous work on this matter, however, was mainly concerned with the dependence of the transition enthalpy on external parameters, such as the ionic strength, or with the melting of nuclei from different sources. In this paper we report the structural assignment of the transitions of rat liver nuclei, observed at 58, 66, 75, 92, and 107 degrees C. They are representative of the quiescent state of the cell. The strategy adopted in this work builds on the method developed for the investigation of complex biological macromolecules. The heat absorption profile of the nucleus was related to the denaturation of isolated nuclear components; electron microscopy and electrophoretic techniques were used for their morphological and molecular characterization. The digestion of chromatin by endogenous nuclease mimics perfectly the decondensation of the higher order structure and represented the source of several misinterpretations. This point was carefully examined in order to define unambiguously the thermal profile of native nuclei. The low-temperature transitions, centered around 58 and 66 degrees C, arise from the melting of scaffolding structures and of the proteins associated with heterogeneous nuclear RNA.(ABSTRACT TRUNCATED AT 250 WORDS)

Mg I as a probe of the solar chromosphere - The atomic model

NASA Technical Reports Server (NTRS)

Mauas, Pablo J.; Avrett, Eugene H.; Loeser, Rudolf

1988-01-01

This paper presents a complete atomic model for Mg I line synthesis, where all the atomic parameters are based on recent experimental and theoretical data. It is shown how the computed profiles at 4571 A and 5173 A are influenced by the choice of these parameters and the number of levels included in the model atom. In addition, observed profiles of the 5173 A b2 line and theoretical profiles for comparison (based on a recent atmospheric model for the average quiet sun) are presented.

Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence.

PubMed

Taylor, Terence E; Lacalle Muls, Helena; Costello, Richard W; Reilly, Richard B

2018-01-01

Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings. In this study, an audio-based method is presented that accurately estimates inhalation flow profile using only one calibration inhalation audio recording. Twenty healthy participants were asked to perform 15 inhalations through a placebo Ellipta™ DPI at a range of inspiratory flow rates. Inhalation flow signals were recorded using a pneumotachograph spirometer while inhalation audio signals were recorded simultaneously using the Inhaler Compliance Assessment device attached to the inhaler. The acoustic (amplitude) envelope was estimated from each inhalation audio signal. Using only one recording, linear and power law regression models were employed to determine which model best described the relationship between the inhalation acoustic envelope and flow signal. Each model was then employed to estimate the flow signals of the remaining 14 inhalation audio recordings. This process repeated until each of the 15 recordings were employed to calibrate single models while testing on the remaining 14 recordings. It was observed that power law models generated the highest average flow estimation accuracy across all participants (90.89±0.9% for power law models and 76.63±2.38% for linear models). The method also generated sufficient accuracy in estimating inhalation parameters such as peak inspiratory flow rate and inspiratory capacity within the presence of noise. Estimating inhaler inhalation flow profiles using audio based methods may be clinically beneficial for inhaler technique training and the remote monitoring of patient adherence.

Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence

PubMed Central

Lacalle Muls, Helena; Costello, Richard W.; Reilly, Richard B.

2018-01-01

Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings. In this study, an audio-based method is presented that accurately estimates inhalation flow profile using only one calibration inhalation audio recording. Twenty healthy participants were asked to perform 15 inhalations through a placebo Ellipta™ DPI at a range of inspiratory flow rates. Inhalation flow signals were recorded using a pneumotachograph spirometer while inhalation audio signals were recorded simultaneously using the Inhaler Compliance Assessment device attached to the inhaler. The acoustic (amplitude) envelope was estimated from each inhalation audio signal. Using only one recording, linear and power law regression models were employed to determine which model best described the relationship between the inhalation acoustic envelope and flow signal. Each model was then employed to estimate the flow signals of the remaining 14 inhalation audio recordings. This process repeated until each of the 15 recordings were employed to calibrate single models while testing on the remaining 14 recordings. It was observed that power law models generated the highest average flow estimation accuracy across all participants (90.89±0.9% for power law models and 76.63±2.38% for linear models). The method also generated sufficient accuracy in estimating inhalation parameters such as peak inspiratory flow rate and inspiratory capacity within the presence of noise. Estimating inhaler inhalation flow profiles using audio based methods may be clinically beneficial for inhaler technique training and the remote monitoring of patient adherence. PMID:29346430

The Boundary Layer Flows of a Rivlin-Ericksen Fluid

NASA Astrophysics Data System (ADS)

Sadeghy, K.; Khabazi, N.; Taghavi, S. M.

The present work deals with the two-dimensional incompressible, laminar, steady-state boundary layer equations. First, we determine a family of velocity distributions outside the boundary layer such that these problems may have similarity solutions. We study the Falkner-Skan flow of a viscoelastic fluid governed by second order model, as the Reynolds number Re→ ∞. We obtain an ordinary forth order differential equation to obtain the stream function, velocity profile and the stress. The stream function is then governed by a generalized Falkner-Skan equation. In comparison with Newtonian Falkner-Skan equation that has two coefficients this new one has four coefficients that two of them represent elastic properties of the fluid. The effects of the elastic parameter on the velocity filed have been discussed. As it is shown in the figure there is a good agreement between numerical results and previous special cases confirm the validity of the presented algorithm.

Mechatronic modeling of a 750kW fixed-speed wind energy conversion system using the Bond Graph Approach.

PubMed

Khaouch, Zakaria; Zekraoui, Mustapha; Bengourram, Jamaa; Kouider, Nourreeddine; Mabrouki, Mustapha

2016-11-01

In this paper, we would like to focus on modeling main parts of the wind turbines (blades, gearbox, tower, generator and pitching system) from a mechatronics viewpoint using the Bond-Graph Approach (BGA). Then, these parts are combined together in order to simulate the complete system. Moreover, the real dynamic behavior of the wind turbine is taken into account and with the new model; final load simulation is more realistic offering benefits and reliable system performance. This model can be used to develop control algorithms to reduce fatigue loads and enhance power production. Different simulations are carried-out in order to validate the proposed wind turbine model, using real data provided in the open literature (blade profile and gearbox parameters for a 750 kW wind turbine). Copyright © 2016 ISA. Published by Elsevier Ltd. All rights reserved.

Giant hub Src and Syk tyrosine kinase thermodynamic profiles recapitulate evolution

NASA Astrophysics Data System (ADS)

Phillips, J. C.

2017-10-01

Thermodynamic scaling theory, previously applied mainly to small proteins, here analyzes quantitative evolution of the titled functional network giant hub enzymes. The broad domain structure identified homologically is confirmed hydropathically using amino acid sequences only. The most surprising results concern the evolution of the tyrosine kinase globular surface roughness from avians to mammals, which is first order, compared to the evolution within mammals from rodents to humans, which is second order. The mystery of the unique amide terminal region of proto oncogene tyrosine protein kinase is resolved by the discovery there of a rare hydroneutral septad targeting cluster, which is paralleled by an equally rare octad catalytic cluster in tyrosine kinase in humans and a few other species (cat and dog). These results, which go far towards explaining why these proteins are among the largest giant hubs in protein interaction networks, use no adjustable parameters.

Does the performance of wet granulation and tablet hardness affect the drug dissolution profile of carvedilol in matrix tablets?

PubMed

Košir, Darjan; Ojsteršek, Tadej; Vrečer, Franc

2018-06-14

Wet granulation is mostly used process for manufacturing matrix tablets. Compared to the direct compression method, it allows for a better flow and compressibility properties of compression mixtures. Granulation, including process parameters and tableting, can influence critical quality attributes (CQAs) of hydrophilic matrix tablets. One of the most important CQAs is the drug release profile. We studied the influence of granulation process parameters (type of nozzle and water quantity used as granulation liquid) and tablet hardness on the drug release profile. Matrix tablets contained HPMC K4M hydrophilic matrix former and carvedilol as a model drug. The influence of selected HPMC characteristics on the drug release profile was also evaluated using two additional HPMC batches. For statistical evaluation, partial least square (PLS) models were generated for each time point of the drug release profile using the same number of latent factors. In this way, it was possible to evaluate how the importance of factors influencing drug dissolution changes in dependence on time throughout the drug release profile. The results of statistical evaluation show that the granulation process parameters (granulation liquid quantity and type of nozzle) and tablet hardness significantly influence the release profile. On the other hand, the influence of HPMC characteristics is negligible in comparison to the other factors studied. Using a higher granulation liquid quantity and the standard nozzle type results in larger granules with a higher density and lower porosity, which leads to a slower drug release profile. Lower tablet hardness also slows down the release profile.

Utilization of Gastrointestinal Simulator, an in Vivo Predictive Dissolution Methodology, Coupled with Computational Approach To Forecast Oral Absorption of Dipyridamole.

PubMed

Matsui, Kazuki; Tsume, Yasuhiro; Takeuchi, Susumu; Searls, Amanda; Amidon, Gordon L

2017-04-03

Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, which makes it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the gastrointestinal simulator (GIS), a novel in vivo predictive dissolution (iPD) methodology, in predicting the in vivo behavior of the weakly basic drug dipyridamole when coupled with in silico analysis. The GIS is a multicompartmental dissolution apparatus, which represents physiological gastric emptying in the fasted state. Kinetic parameters for drug dissolution and precipitation were optimized by fitting a curve to the dissolved drug amount-time profiles in the United States Pharmacopeia apparatus II and GIS. Optimized parameters were incorporated into mathematical equations to describe the mass transport kinetics of dipyridamole in the GI tract. By using this in silico model, intraluminal drug concentration-time profile was simulated. The predicted profile of dipyridamole in the duodenal compartment adequately captured observed data. In addition, the plasma concentration-time profile was also predicted using pharmacokinetic parameters following intravenous administration. On the basis of the comparison with observed data, the in silico approach coupled with the GIS successfully predicted in vivo pharmacokinetic profiles. Although further investigations are still required to generalize, these results indicated that incorporating GIS data into mathematical equations improves the predictability of in vivo behavior of weakly basic drugs like dipyridamole.

A risk-based approach to management of leachables utilizing statistical analysis of extractables.

PubMed

Stults, Cheryl L M; Mikl, Jaromir; Whelehan, Oliver; Morrical, Bradley; Duffield, William; Nagao, Lee M

2015-04-01

To incorporate quality by design concepts into the management of leachables, an emphasis is often put on understanding the extractable profile for the materials of construction for manufacturing disposables, container-closure, or delivery systems. Component manufacturing processes may also impact the extractable profile. An approach was developed to (1) identify critical components that may be sources of leachables, (2) enable an understanding of manufacturing process factors that affect extractable profiles, (3) determine if quantitative models can be developed that predict the effect of those key factors, and (4) evaluate the practical impact of the key factors on the product. A risk evaluation for an inhalation product identified injection molding as a key process. Designed experiments were performed to evaluate the impact of molding process parameters on the extractable profile from an ABS inhaler component. Statistical analysis of the resulting GC chromatographic profiles identified processing factors that were correlated with peak levels in the extractable profiles. The combination of statistically significant molding process parameters was different for different types of extractable compounds. ANOVA models were used to obtain optimal process settings and predict extractable levels for a selected number of compounds. The proposed paradigm may be applied to evaluate the impact of material composition and processing parameters on extractable profiles and utilized to manage product leachables early in the development process and throughout the product lifecycle.

[Altitude-belt zonality of wood vegetation within mountainous regions of the Sayan Mountains: a model of ecological second-order phase transitions ].

PubMed

Sukhovol'skiĭ, V G; Ovchinnikova, T M; Baboĭ, S D

2014-01-01

As a description of altitude-belt zonality of wood vegetation, a model of ecological second-order transitions is proposed. Objects of the study have been chosen to be forest cenoses of the northern slope of Kulumyss Ridge (the Sayan Mauntains), while the results are comprised by the altitude profiles of wood vegetation. An ecological phase transition can be considered as the transition of cenoses at different altitudes from the state of presence of certain tree species within the studied territory to the state of their absence. By analogy with the physical model of second-order, phase transitions the order parameter is introduced (i.e., the area portion occupied by a single tree species at the certain altitude) as well as the control variable (i.e., the altitude of the wood vegetation belt). As the formal relation between them, an analog of the Landau's equation for phase transitions in physical systems is obtained. It is shown that the model is in a good accordance with the empirical data. Thus, the model can be used for estimation of upper and lower boundaries of altitude belts for individual tree species (like birch, aspen, Siberian fir, Siberian pine) as well as the breadth of their ecological niches with regard to altitude. The model includes also the parameters that describe numerically the interactions between different species of wood vegetation. The approach versatility allows to simplify description and modeling of wood vegetation altitude zonality, and enables assessment of vegetation cenoses response to climatic changes.

Optimal experimental design for parameter estimation of a cell signaling model.

PubMed

Bandara, Samuel; Schlöder, Johannes P; Eils, Roland; Bock, Hans Georg; Meyer, Tobias

2009-11-01

Differential equation models that describe the dynamic changes of biochemical signaling states are important tools to understand cellular behavior. An essential task in building such representations is to infer the affinities, rate constants, and other parameters of a model from actual measurement data. However, intuitive measurement protocols often fail to generate data that restrict the range of possible parameter values. Here we utilized a numerical method to iteratively design optimal live-cell fluorescence microscopy experiments in order to reveal pharmacological and kinetic parameters of a phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) second messenger signaling process that is deregulated in many tumors. The experimental approach included the activation of endogenous phosphoinositide 3-kinase (PI3K) by chemically induced recruitment of a regulatory peptide, reversible inhibition of PI3K using a kinase inhibitor, and monitoring of the PI3K-mediated production of PIP(3) lipids using the pleckstrin homology (PH) domain of Akt. We found that an intuitively planned and established experimental protocol did not yield data from which relevant parameters could be inferred. Starting from a set of poorly defined model parameters derived from the intuitively planned experiment, we calculated concentration-time profiles for both the inducing and the inhibitory compound that would minimize the predicted uncertainty of parameter estimates. Two cycles of optimization and experimentation were sufficient to narrowly confine the model parameters, with the mean variance of estimates dropping more than sixty-fold. Thus, optimal experimental design proved to be a powerful strategy to minimize the number of experiments needed to infer biological parameters from a cell signaling assay.

A computational analysis subject to thermophysical aspects of Sisko fluid flow over a cylindrical surface

NASA Astrophysics Data System (ADS)

Awais, M.; Khalil-Ur-Rehman; Malik, M. Y.; Hussain, Arif; Salahuddin, T.

2017-09-01

The present analysis is devoted to probing the salient features of the mixed convection and non-linear thermal radiation effects on non-Newtonian Sisko fluid flow over a linearly stretching cylindrical surface. Properties of heat transfer are outlined via variable thermal conductivity and convective boundary conditions. The boundary layer approach is implemented to construct the mathematical model in the form of partial differential equations. Then, the requisite PDEs are transmuted into a complex ordinary differential system by invoking appropriate dimensionless variables. Solution of subsequent ODEs is obtained by utilizing the Runge-Kutta algorithm (fifth order) along with the shooting scheme. The graphical illustrations are presented to interpret the features of the involved pertinent flow parameters on concerning profiles. For a better description of the fluid flow, numerical variations in local skin friction coefficient and local Nusselt number are scrutinized in tables. From thorough analysis, it is inferred that the mixed convection parameter and the curvature parameter increase the velocity while temperature shows a different behavior. Additionally, both momentum and thermal distribution of fluid flow decrease with increasing values of the non-linearity index. Furthermore, variable thermal parameter and heat generation/absorption parameter amplify the temperature significantly. The skin friction is an increasing function of all momentum controlling parameters. The local Nusselt number also shows a similar behavior against heat radiation parameter and variable thermal conductivity parameter while it shows a dual nature for the heat generation/absorption parameter. Finally, the obtained results are validated by comparison with the existing literature and hence the correctness of the analysis is proved.

An Empirical Study on Raman Peak Fitting and Its Application to Raman Quantitative Research.

PubMed

Yuan, Xueyin; Mayanovic, Robert A

2017-10-01

Fitting experimentally measured Raman bands with theoretical model profiles is the basic operation for numerical determination of Raman peak parameters. In order to investigate the effects of peak modeling using various algorithms on peak fitting results, the representative Raman bands of mineral crystals, glass, fluids as well as the emission lines from a fluorescent lamp, some of which were measured under ambient light whereas others under elevated pressure and temperature conditions, were fitted using Gaussian, Lorentzian, Gaussian-Lorentzian, Voigtian, Pearson type IV, and beta profiles. From the fitting results of the Raman bands investigated in this study, the fitted peak position, intensity, area and full width at half-maximum (FWHM) values of the measured Raman bands can vary significantly depending upon which peak profile function is used in the fitting, and the most appropriate fitting profile should be selected depending upon the nature of the Raman bands. Specifically, the symmetric Raman bands of mineral crystals and non-aqueous fluids are best fit using Gaussian-Lorentzian or Voigtian profiles, whereas the asymmetric Raman bands are best fit using Pearson type IV profiles. The asymmetric O-H stretching vibrations of H 2 O and the Raman bands of soda-lime glass are best fit using several Gaussian profiles, whereas the emission lines from a florescent light are best fit using beta profiles. Multiple peaks that are not clearly separated can be fit simultaneously, provided the residuals in the fitting of one peak will not affect the fitting of the remaining peaks to a significant degree. Once the resolution of the Raman spectrometer has been properly accounted for, our findings show that the precision in peak position and intensity can be improved significantly by fitting the measured Raman peaks with appropriate profiles. Nevertheless, significant errors in peak position and intensity were still observed in the results from fitting of weak and wide Raman bands having unnormalized intensity/FWHM ratios lower than 200 counts/cm -1 .

He, U, and Th Depth Profiling of Apatite and Zircon Using Laser Ablation Noble Gas Mass Spectrometry and SIMS

NASA Astrophysics Data System (ADS)

Monteleone, B. D.; van Soest, M. C.; Hodges, K. V.; Hervig, R.; Boyce, J. W.

2008-12-01

Conventional (U-Th)/He thermochronology utilizes single or multiple grain analyses of U- and Th-bearing minerals such as apatite and zircon and does not allow for assessment of spatial variation in concentration of He, U, or Th within individual crystals. As such, age calculation and interpretation require assumptions regarding 4He loss through alpha ejection, diffusive redistribution of 4He, and U and Th distribution as an initial condition for these processes. Although models have been developed to predict 4He diffusion parameters, correct for the effect of alpha ejection on calculated cooling ages, and account for the effect of U and Th zonation within apatite and zircon, measurements of 4He, U, and Th distribution have not been combined within a single crystal. We apply ArF excimer laser ablation, combined with noble gas mass spectrometry, to obtain depth profiles within apatite and zircon crystals in order to assess variations in 4He concentration with depth. Our initial results from pre-cut, pre-heated slabs of Durango apatite, each subjected to different T-t schedules, suggest a general agreement of 4He profiles with those predicted by theoretical diffusion models (Farley, 2000). Depth profiles through unpolished grains give reproducible alpha ejection profiles in Durango apatite that deviate from alpha ejection profiles predicted for ideal, homogenous crystals. SIMS depth profiling utilizes an O2 primary beam capable of sputtering tens of microns and measuring sub-micron resolution variation in [U], [Th], and [Sm]. Preliminary results suggest that sufficient [U] and [Th] zonation is present in Durango apatite to influence the form of the 4He alpha ejection profile. Future work will assess the influence of measured [U] and [Th] zonation on previously measured 4He depth profiles. Farley, K.A., 2000. Helium diffusion from apatite; general behavior as illustrated by Durango fluorapatite. J. Geophys. Res., B Solid Earth Planets 105 (2), 2903-2914.

Magnetohydrodynamics of unsteady viscous fluid on boundary layer past a sliced sphere

NASA Astrophysics Data System (ADS)

Nursalim, Rahmat; Widodo, Basuki; Imron, Chairul

2017-10-01

Magnetohydrodynamics (MHD) is important study in engineering and industrial fields. By study on MHD, we can reach the fluid flow characteristics that can be used to minimize its negative effect to an object. In decades, MHD has been widely studied in various geometry forms and fluid types. The sliced sphere is a geometry form that has not been investigated. In this paper we study magnetohydrodynamics of unsteady viscous fluid on boundary layer past a sliced sphere. Assumed that the fluid is incompressible, there is no magnetic field, there is no electrical voltage, the sliced sphere is fix and there is no barrier around the object. In this paper we focus on velocity profile at stagnation point (x = 0°). Mathematical model is governed by continuity and momentum equation. It is converted to non-dimensional, stream function, and similarity equation. Solution of the mathematical model is obtained by using Keller-Box numerical method. By giving various of slicing angle and various of magnetic parameter we get the simulation results. The simulation results show that increasing the slicing angle causes the velocity profile be steeper. Also, increasing the value of magnetic parameter causes the velocity profile be steeper. On the large slicing angle there is no significant effect of magnetic parameter to velocity profile, and on the high the value of magnetic parameter there is no significant effect of slicing angle to velocity profile.

Statistical Nature of Atomic Disorder in Irradiated Crystals.

PubMed

Boulle, A; Debelle, A

2016-06-17

Atomic disorder in irradiated materials is investigated by means of x-ray diffraction, using cubic SiC single crystals as a model material. It is shown that, besides the determination of depth-resolved strain and damage profiles, x-ray diffraction can be efficiently used to determine the probability density function (PDF) of the atomic displacements within the crystal. This task is achieved by analyzing the diffraction-order dependence of the damage profiles. We thereby demonstrate that atomic displacements undergo Lévy flights, with a displacement PDF exhibiting heavy tails [with a tail index in the γ=0.73-0.37 range, i.e., far from the commonly assumed Gaussian case (γ=2)]. It is further demonstrated that these heavy tails are crucial to account for the amorphization kinetics in SiC. From the retrieved displacement PDFs we introduce a dimensionless parameter f_{D}^{XRD} to quantify the disordering. f_{D}^{XRD} is found to be consistent with both independent measurements using ion channeling and with molecular dynamics calculations.

A physical mechanism for the onset of radial electric fields in magnetically confined plasmas

NASA Astrophysics Data System (ADS)

Moleti, A.

1996-04-01

A simple physical mechanism is described, which could trigger the Low-mode to High-mode (L-H) transition. The instantaneous ion density profile is significantly modified by a sudden temperature increase, because Larmor radii and banana orbit widths are proportional to thermal velocity. The electric fields that are observed in H-mode plasmas could be produced in the radial region where a large second derivative of the density profile exists, either by strong additional heating or by the heat pulse associated to a sawtooth crash. The L-H transition threshold for the time derivative of the ion temperature is of the order of magnitude of the values that are measured in the outer part of the plasma by electron temperature fast diagnostics at sawtooth crashes. This model agrees with the experimental evidence that L-H transitions are often triggered by a sawtooth crash, and the predicted dependence of the threshold on plasma parameters is fairly consistent with available data.

Enhanced Carbon Diffusion in Austenitic Stainless Steel Carburized at Low Temperature

NASA Astrophysics Data System (ADS)

Ernst, F.; Avishai, A.; Kahn, H.; Gu, X.; Michal, G. M.; Heuer, A. H.

2009-08-01

Austenitic stainless steel AISI 316L was carburized by a novel, low-temperature gas-phase process. Using a calibrated scanning Auger microprobe (SAM) analysis of cross-sectional specimens under dynamic sputtering, we determined the fraction-depth profile of carbon. The profile is concave—very different from the shape expected for concentration-independent diffusion—and indicates a carbide-free solid solution with carbon levels up to 15 at. pct and a case depth of ≈30 μm. A Boltzmann-Matano analysis with a careful evaluation of the stochastic and potential systematic errors indicates that increasing levels of carbon significantly enhance carbon diffusion. For the highest carbon level observed (15 at. pct), the carbon diffusion coefficient is more than two orders of magnitude larger than in dilute solution. The most likely explanation for this strong increase is that carbon-induced local expansion of metal-metal atom distances, observed as an expansion of the lattice parameter, reduces the activation energy for carbon diffusion.

Electronic structures of GeSi nanoislands grown on pit-patterned Si(001) substrate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ye, Han, E-mail: Dabombyh@aliyun.com; Yu, Zhongyuan

2014-11-15

Patterning pit on Si(001) substrate prior to Ge deposition is an important approach to achieve GeSi nanoislands with high ordering and size uniformity. In present work, the electronic structures of realistic uncapped pyramid, dome, barn and cupola nanoislands grown in (105) pits are systematically investigated by solving Schrödinger equation for heavy-hole, which resorts to inhomogeneous strain distribution and nonlinear composition-dependent band parameters. Uniform, partitioned and equilibrium composition profile (CP) in nanoisland and inverted pyramid structure are simulated separately. We demonstrate the huge impact of composition profile on localization of heavy-hole: wave function of ground state is confined near pit facetsmore » for uniform CP, at bottom of nanoisland for partitioned CP and at top of nanoisland for equilibrium CP. Moreover, such localization is gradually compromised by the size effect as pit filling ratio or pit size decreases. The results pave the fundamental guideline of designing nanoislands on pit-patterned substrates for desired applications.« less

Statistical Nature of Atomic Disorder in Irradiated Crystals

NASA Astrophysics Data System (ADS)

Boulle, A.; Debelle, A.

2016-06-01

Atomic disorder in irradiated materials is investigated by means of x-ray diffraction, using cubic SiC single crystals as a model material. It is shown that, besides the determination of depth-resolved strain and damage profiles, x-ray diffraction can be efficiently used to determine the probability density function (PDF) of the atomic displacements within the crystal. This task is achieved by analyzing the diffraction-order dependence of the damage profiles. We thereby demonstrate that atomic displacements undergo Lévy flights, with a displacement PDF exhibiting heavy tails [with a tail index in the γ =0.73 - 0.37 range, i.e., far from the commonly assumed Gaussian case (γ =2 )]. It is further demonstrated that these heavy tails are crucial to account for the amorphization kinetics in SiC. From the retrieved displacement PDFs we introduce a dimensionless parameter fDXRD to quantify the disordering. fDXRD is found to be consistent with both independent measurements using ion channeling and with molecular dynamics calculations.

Experimental Determination of Infrared Extinction Coefficients of Interplanetary Dust Particles

NASA Technical Reports Server (NTRS)

Spann, J. F., Jr.; Abbas, M. M.

1998-01-01

This technique is based on irradiating a single isolated charged dust particle suspended in balance by an electric field, and measuring the scattered radiation as a function of angle. The observed scattered intensity profile at a specific wavelength obtained for a dust particle of known composition is compared with Mie theory calculations, and the variable parameters relating to the particle size and complex refractive index are adjusted for a best fit between the two profiles. This leads to a simultaneous determination of the particle radius, the complex refractive index, and the scattering and extinction coefficients. The results of these experiments can be utilized to examine the IRAS and DIRBE (Diffuse Infrared Background Experiment) infrared data sets in order to determine the dust particle physical characteristics and distributions by using infrared models and inversion techniques. This technique may also be employed for investigation of the rotational bursting phenomena whereby large size cosmic and interplanetary particles are believed to fragment into smaller dust particles.

Brain blood vessel segmentation using line-shaped profiles

NASA Astrophysics Data System (ADS)

Babin, Danilo; Pižurica, Aleksandra; De Vylder, Jonas; Vansteenkiste, Ewout; Philips, Wilfried

2013-11-01

Segmentation of cerebral blood vessels is of great importance in diagnostic and clinical applications, especially for embolization of cerebral aneurysms and arteriovenous malformations (AVMs). In order to perform embolization of the AVM, the structural and geometric information of blood vessels from 3D images is of utmost importance. For this reason, the in-depth segmentation of cerebral blood vessels is usually done as a fusion of different segmentation techniques, often requiring extensive user interaction. In this paper we introduce the idea of line-shaped profiling with an application to brain blood vessel and AVM segmentation, efficient both in terms of resolving details and in terms of computation time. Our method takes into account both local proximate and wider neighbourhood of the processed pixel, which makes it efficient for segmenting large blood vessel tree structures, as well as fine structures of the AVMs. Another advantage of our method is that it requires selection of only one parameter to perform segmentation, yielding very little user interaction.

Higher modes of the Orr-Sommerfeld problem for boundary layer flows

NASA Technical Reports Server (NTRS)

Lakin, W. D.; Grosch, C. E.

1983-01-01

The discrete spectrum of the Orr-Sommerfeld problem of hydrodynamic stability for boundary layer flows in semi-infinite regions is examined. Related questions concerning the continuous spectrum are also addressed. Emphasis is placed on the stability problem for the Blasius boundary layer profile. A general theoretical result is given which proves that the discrete spectrum of the Orr-Sommerfeld problem for boundary layer profiles (U(y), 0,0) has only a finite number of discrete modes when U(y) has derivatives of all orders. Details are given of a highly accurate numerical technique based on collocation with splines for the calculation of stability characteristics. The technique includes replacement of 'outer' boundary conditions by asymptotic forms based on the proper large parameter in the stability problem. Implementation of the asymptotic boundary conditions is such that there is no need to make apriori distinctions between subcases of the discrete spectrum or between the discrete and continuous spectrums. Typical calculations for the usual Blasius problem are presented.

Stochastic models for inferring genetic regulation from microarray gene expression data.

PubMed

Tian, Tianhai

2010-03-01

Microarray expression profiles are inherently noisy and many different sources of variation exist in microarray experiments. It is still a significant challenge to develop stochastic models to realize noise in microarray expression profiles, which has profound influence on the reverse engineering of genetic regulation. Using the target genes of the tumour suppressor gene p53 as the test problem, we developed stochastic differential equation models and established the relationship between the noise strength of stochastic models and parameters of an error model for describing the distribution of the microarray measurements. Numerical results indicate that the simulated variance from stochastic models with a stochastic degradation process can be represented by a monomial in terms of the hybridization intensity and the order of the monomial depends on the type of stochastic process. The developed stochastic models with multiple stochastic processes generated simulations whose variance is consistent with the prediction of the error model. This work also established a general method to develop stochastic models from experimental information. 2009 Elsevier Ireland Ltd. All rights reserved.

Perspective on the reactions between F– and CH3CH2F: The free energy landscape of the E2 and SN2 reaction channels

PubMed Central

Ensing, Bernd; Klein, Michael L.

2005-01-01

Recently, we computed the 3D free energy surface of the base-induced elimination reaction between F– and CH3CH2F by using a powerful technique within Car–Parrinello molecular dynamics simulation. Here, the set of three order parameters is expanded to six, which allows the study of the competing elimination and substitution reactions simultaneously. The power of the method is exemplified by the exploration of the six-dimensional free energy landscape, sampling, and mapping out the eight stable states as well as the connecting bottlenecks. The free energy profile and barrier along the E2 and SN2 reaction channels are refined by using umbrella sampling. The two mechanisms do not share a common “E2C-like” transition state. Comparison with the zero temperature profiles shows a particularly significant entropy contribution to the SN2 channel. PMID:15863622

Time-domain approach for the transient responses in stratified viscoelastic Earth models

NASA Technical Reports Server (NTRS)

Hanyk, L.; Moser, J.; Yuen, D. A.; Matyska, C.

1995-01-01

We have developed the numerical algorithm for the computation of transient viscoelastic responses in the time domain for a radially stratified Earth model. Stratifications in both the elastic parameters and the viscosity profile have been considered. The particular viscosity profile employed has a viscosity maximum with a constrast of O(100) in the mid lower mantle. The distribution of relaxation times reveals the presence of a continuous spectrum situated between O(100) and O(exp 4) years. The principal mode is embedded within this continuous spectrum. From this initial-value approach we have found that for the low degree harmonics the non-modal contributions are comparable to the modal contributions. For this viscosity model the differences between the time-domain and normal-mode results are found to decrease strongly with increasing angular order. These calculations also show that a time-dependent effective relaxation time can be defined, which can be bounded by the relaxation times of the principal modes.

Relevant principal component analysis applied to the characterisation of Portuguese heather honey.

PubMed

Martins, Rui C; Lopes, Victor V; Valentão, Patrícia; Carvalho, João C M F; Isabel, Paulo; Amaral, Maria T; Batista, Maria T; Andrade, Paula B; Silva, Branca M

2008-01-01

The main purpose of this study was the characterisation of 'Serra da Lousã' heather honey by using novel statistical methodology, relevant principal component analysis, in order to assess the correlations between production year, locality and composition. Herein, we also report its chemical composition in terms of sugars, glycerol and ethanol, and physicochemical parameters. Sugars profiles from 'Serra da Lousã' heather and 'Terra Quente de Trás-os-Montes' lavender honeys were compared and allowed the discrimination: 'Serra da Lousã' honeys do not contain sucrose, generally exhibit lower contents of turanose, trehalose and maltose and higher contents of fructose and glucose. Different localities from 'Serra da Lousã' provided groups of samples with high and low glycerol contents. Glycerol and ethanol contents were revealed to be independent of the sugars profiles. These data and statistical models can be very useful in the comparison and detection of adulterations during the quality control analysis of 'Serra da Lousã' honey.

Mesoscopic modeling of structural and thermodynamic properties of fluids confined by rough surfaces.

PubMed

Terrón-Mejía, Ketzasmin A; López-Rendón, Roberto; Gama Goicochea, Armando

2015-10-21

The interfacial and structural properties of fluids confined by surfaces of different geometries are studied at the mesoscopic scale using dissipative particle dynamics simulations in the grand canonical ensemble. The structure of the surfaces is modeled by a simple function, which allows us to simulate readily different types of surfaces through the choice of three parameters only. The fluids we have modeled are confined either by two smooth surfaces or by symmetrically and asymmetrically structured walls. We calculate structural and thermodynamic properties such as the density, temperature and pressure profiles, as well as the interfacial tension profiles for each case and find that a structural order-disorder phase transition occurs as the degree of surface roughness increases. However, the magnitude of the interfacial tension is insensitive to the structuring of the surfaces and depends solely on the magnitude of the solid-fluid interaction. These results are important for modern nanotechnology applications, such as in the enhanced recovery of oil, and in the design of porous materials with specifically tailored properties.

Laser depth profiling of diffusion and alpha ejection profiles in Durango apatite: testing the fundamental parameters of apatite (U-Th)/He dating

NASA Astrophysics Data System (ADS)

van Soest, M. C.; Monteleone, B. D.; Boyce, J. W.; Hodges, K.

2009-12-01

Since its development (e.g. Zeitler et al., 1987, Lippolt et al., 1994, Farley et al., 1996, Wolf et al., 1996) as a viable low temperature thermochronological method (U-Th)/He dating of apatite has become a popular and widely applied low temperature thermochronometer. The method has been applied with success to a great variety of geological problems, and the fundamental parameters of the method: the bulk diffusion parameters of helium in apatite, and the calculated theoretical helium stopping distance in apatite used to correct the ages for the effects of alpha ejection appear sound. However, the development of the UV laser microprobe technique for the (U-Th)/He method (Boyce et al., 2006) allows for in-situ testing of the helium bulk diffusion parameters (Farley, 2000) and can provide a direct measurement of the alpha ejection distance in apatite. So, with the ultimate goal of further developing the in-situ (U-Th)/He dating method and micro-analytical depth profiling techniques to constrain cooling histories in natural grains, we conducted a helium depth profiling study of induced diffusion and natural alpha ejection profiles in Durango apatite. For the diffusion depth profiling, a Durango crystal was cut in slabs oriented parallel and perpendicular to the crystal c-axis. The slabs were polished and heated using different temperature and time schedules to induce predictable diffusion profiles based on the bulk helium diffusion parameters in apatite. Depth profiling of the 4He diffusion profiles was done using an ArF excimer laser. The measured diffusion depth profiles at 350°, 400°, and 450° C coincide well with the predicted bulk diffusion curves, independent of slab orientation, but the 300° C profiles consistently deviate significantly. The possible cause for this deviation is currently being investigated. Alpha ejection profiling was carried out on crystal margins from two different Durango apatite crystals, several faces from each crystal were analyzed to evaluate the potential effects of crystallographic orientation on alpha ejection. The results from both crystals were very reproducible irrespective of crystal surface used and confirm the findings of Monteleone et al. (2008) that the measured alpha ejection profiles deviate significantly from and are shorter than the calculated theoretical average value. Efforts are currently underway to better constrain the measured alpha ejection distance and measure alpha ejection profiles in apatite crystals other than Durango apatite. References: Boyce, J. et al. (2006) GCA 70, pp. 3031-3039. Farley, K. et al. (1996) GCA 60, pp. 4223-4229. Farley, K. (2006) JGR SE 105, p. 2903-2914. Lippolt, H. et al. (1994) Chem Geol 112, pp. 179-191. Monteleone, B. et al. (2008) Eos Trans AGU, 89 Fall Meeting V53B-2162. Wolf, R. et al. (1996) GCA 60, pp. 4231-4240. Zeitler, P. et al. (1987) GCA 51, pp. 2865-2868.

Détermination du profil de modulation des réseaux holographiques de phase

NASA Astrophysics Data System (ADS)

Mechahougui, S.; Harthong, J.; Medjahed, A.

1993-12-01

The complete knowledge of the geometrical and physic-chemical parameters of a periodically modulated volume material, permits the determination of the diffraction picture. Such a purely mathematical and numerical determination is of great scientific and technological interest. The modulation profile (given by its Fourier coefficients) is one of these parameters. It can be determinated a posteriori only by the measurement of the different diffracted intensities at different orders. Starting from this idea, we can achieve a new method (theoritically exact) which permits the study of the diffraction of an electromagnetic plane wave by a dielectric grating. This method leads to the numerical treatment of ordinary differential equation with variable by periodic coefficients. The method is presented here for the classical case of a wave with electric polarization parallel to the grating. For the analysis of the modulation profile, we have considered realistic models of profiles, contrary to the current models, which have only a numerical existence. In order to achieve our experimental work, we have developed two experimental set-up: the first for the recording and the second for the analysis of diffractive elements. The whole set-up can be directed with the aid of a software from a personal computer. The validity of results are discussed. La connaissance parfaite des paramètres géométriques et physico-chimiques d'un matériau de volume modulé périodiquement, donne une bonne connaissance de la figure de diffraction. Celle-ci a une grande importance scientifique et technologique. Le profil de modulation (donné par ses coefficients de Fourier) est l'un de ces paramètres qui ne peut être déterminé a posteriori qu'à partir de la répartition d'intensité entre les différents ordres. A partir de cette idée, nous avons établi une méthode exacte permettant l'étude de la diffraction d'une onde plane électromagnétique par un réseau diélectrique, qui conduit au traitement numérique d'une équation différentielle à coefficients variables. La méthode est donnée pour le cas classique où le champ électrique est parallèle au plan du réseau. Pour analyser l'influence du profil de modulation, on considère des modèles mathématiques réalistes et non (comme il est courant dans la littérature) des modèles physiques irréalisables. Pour notre travail expérimental nous avons mis au point deux montages : le premier pour l'enregistrement et le second pour l'analyse. Ce dernier est totalement automatisé et piloté par un ordinateur. Les résultats obtenus sont largement discutés.

Galaxy luminosity profiles of SARS clusters

NASA Astrophysics Data System (ADS)

Coenda, V.; Donzelli, C.; Muriel, H.; Quintana, H.; Infante, L.

We have analyzed CCD images in the R filter of 14 Abell clusters of the SARS survey, with cz<40000 km/s. We have obtained the luminosity profiles of 507 galaxies and we have studied several relations between the photometric and structural parameters. In the present contributed paper we analyze the following relations: the Kormendy relation and the correlations among the Sérsic parameters.

Air Force Handbook. 109th Congress

DTIC Science & Technology

2009-01-01

FY06 Combat Survivor Evader Locator (CSEL) Acquisition Status Capabilities/Profile Functions /Performance Parameters 38 • Air Force’s primary source for...Broadcast Service (GBS) Capabilities/Profile Acquisition Status Functions /Performance Parameters • Purchase Requirements (Phase 2): • 3 primary ...Operations (AF CONOPS) that support the CSAF and joint vision of combat operations. • AF CONOPS describe key Air Force mission and/or functional areas

Pharmacokinetic analysis of modified-release metoprolol formulations: An interspecies comparison.

PubMed

De Thaye, Elien; Vervaeck, Anouk; Marostica, Eleonora; Remon, Jean Paul; Van Bocxlaer, Jan; Vervaet, Chris; Vermeulen, An

2017-01-15

In the current study, we investigated the metoprolol absorption kinetics of an in-house produced oral sustained-release formulation, matrices manufactured via prilling, and two commercially available formulations, ZOK-ZID ® (reservoir) and Slow-Lopresor ® (matrix) in both New Zealand White rabbits and Beagle dogs, using a population pharmacokinetic analysis approach. The aim of this study was to compare the in vivo pharmacokinetic (PK) profiles of different formulations based on metoprolol, a selective adrenergic β 1 -receptor antagonist, in dogs and rabbits and to contrast the observed differences. To that end, metoprolol (50 to 200mg) was administered to 6 Beagle dogs and 6 New Zealand White rabbits as a single intravenous (IV) bolus injection and to 8 dogs and 6 rabbits as an oral modified release formulation. To derive pharmacokinetic parameters from the data, a non-linear mixed-effects model was developed using NONMEM ® where the contribution of observations below the limit of detection (BDL, below detection limit) to the parameter estimates was taken into account in the parameter estimation procedure. In both species and for the three modified release formulations, different absorption models were tested to describe the PK of metoprolol following oral dosing. In Beagle dogs, plasma concentration-time profiles were best described using a sequential zero- and first-order absorption model. In rabbits though, the absorption phase was best described using a first-order process only. In both species, the reservoir formulation ZOK-ZID ® was behaving quite similarly. In contrast, the absorption properties of both matrix formulations were rather different between species. This study indicates that the PK of the reservoir formulation is similar in both species, even after accounting for the almost completely missed absorption phase in rabbits. The insights gained further illustrate that rabbits are not very well suited to study the PK of the current matrix formulations in view of their less optimal prolonged release characteristics and the resulting fast decline in metoprolol plasma levels. Copyright © 2016 Elsevier B.V. All rights reserved.

Characterization of zirconium carbides using electron microscopy, optical anisotropy, Auger depth profiles, X-ray diffraction, and electron density calculated by charge flipping method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chinthaka Silva, G.W., E-mail: chinthaka.silva@gmail.com; Kercher, Andrew A., E-mail: rokparent@comcast.net; Hunn, John D., E-mail: hunnjd@ornl.gov

2012-10-15

Samples with five different zirconium carbide compositions (C/Zr molar ratio=0.84, 0.89, 0.95, 1.05, and 1.17) have been fabricated and studied using a variety of experimental techniques. Each sample was zone refined to ensure that the end product was polycrystalline with a grain size of 10-100 {mu}m. It was found that the lattice parameter was largest for the x=0.89 composition and smallest for the x=1.17 total C/Zr composition, but was not linear; this nonlinearity is possibly explained using electron densities calculated using charge flipping technique. Among the five samples, the unit cell of the ZrC{sub 0.89} sample showed the highest electronmore » density, corresponding to the highest carbon incorporation and the largest lattice parameter. The ZrC{sub 0.84} sample showed the lowest carbon incorporation, resulting in a larger number of carbon vacancies and resultant strain. Samples with larger carbon ratios (x=0.95, 1.05, and 1.17) showed a slight decrease in lattice parameter, due to a decrease in electron density. Optical anisotropy measurements suggest that these three samples contained significant amounts of a graphitic carbon phase, not bonded to the Zr atoms. - Graphical abstract: Characterization of zirconium carbides using electron microscopy, optical anisotropy, Auger depth profiles, X-ray diffraction, and electron density calculated by the charge flipping method. Highlights: Black-Right-Pointing-Pointer The lattice parameter variation: ZrC{sub 0.89}>ZrC{sub 0.84}>ZrC{sub 0.95}>ZrC{sub 1.05}>ZrC{sub 1.17}. Black-Right-Pointing-Pointer Surface oxygen with no correlation to the lattice parameter variation. Black-Right-Pointing-Pointer ZrC{sub 0.89} had highest electron densities correspond to highest carbon incorporation. Black-Right-Pointing-Pointer Second highest lattice parameter in ZrC{sub 0.84} due to strain. Black-Right-Pointing-Pointer Unit cell electron density order: ZrC{sub 0.95}>ZrC{sub 1.05}>ZrC{sub 1.17}.« less

On the determination and investigation of the terrestrial ionospheric refractive indices using GEOS-3/ATS-6 satellite-to-satellite tracking data

NASA Technical Reports Server (NTRS)

Liu, A. S.

1978-01-01

When the radio link between two satellites (GEOS-3/ATS-6) is intercepted by the earth's ionosphere and neutral atmosphere, a change in the Doppler frequency results. Travel through the atmosphere causes the Doppler phase to be advanced in the ionosphere's portion and retarded in the neutral portion of the atmosphere. Analysis of the shortening and lengthening of the phase of the Satellite-to-Satellite Tracking (SST) data that passed within 40-700 km above the earth's surface during its ATS-6 to GEOS-3 to ATS-6 path, caused by the atmosphere, results in refractivity versus height profiles. The SST Doppler data were used directly to adjust the GEOS-3 orbit. Perturbation from the Moon, Sun and a 15th order/degree earth gravity field were included in the orbit solution. This orbit was continued through the occultation period and a model ionosphere was estimated by a least-square adjustment of the Chapman ionosphere parameters from the SST data residuals. The refractivity profile obtained by this model ionosphere was compared to a refractivity profile obtained by a direct integral inversion of the SST data residuals. Systematic differences between the 2 methods were caused by orbital errors, which propagated into the solution. The SST data yielded refractive index profiles in a novel economical manner because no additional or special on-board equipment were required.

Constraining ecosystem processes from tower fluxes and atmospheric profiles.

PubMed

Hill, T C; Williams, M; Woodward, F I; Moncrieff, J B

2011-07-01

The planetary boundary layer (PBL) provides an important link between the scales and processes resolved by global atmospheric sampling/modeling and site-based flux measurements. The PBL is in direct contact with the land surface, both driving and responding to ecosystem processes. Measurements within the PBL (e.g., by radiosondes, aircraft profiles, and flask measurements) have a footprint, and thus an integrating scale, on the order of 1-100 km. We use the coupled atmosphere-biosphere model (CAB) and a Bayesian data assimilation framework to investigate the amount of biosphere process information that can be inferred from PBL measurements. We investigate the information content of PBL measurements in a two-stage study. First, we demonstrate consistency between the coupled model (CAB) and measurements, by comparing the model to eddy covariance flux tower measurements (i.e., water and carbon fluxes) and also PBL scalar profile measurements (i.e., water, carbon dioxide, and temperature) from Canadian boreal forest. Second, we use the CAB model in a set of Bayesian inversions experiments using synthetic data for a single day. In the synthetic experiment, leaf area and respiration were relatively well constrained, whereas surface albedo and plant hydraulic conductance were only moderately constrained. Finally, the abilities of the PBL profiles and the eddy covariance data to constrain the parameters were largely similar and only slightly lower than the combination of both observations.

Determination and analysis of non-linear index profiles in electron-beam-deposited MgOAl2O3ZrO2 ternary composite thin-film optical coatings

NASA Astrophysics Data System (ADS)

Sahoo, N. K.; Thakur, S.; Senthilkumar, M.; Das, N. C.

2005-02-01

Thickness-dependent index non-linearity in thin films has been a thought provoking as well as intriguing topic in the field of optical coatings. The characterization and analysis of such inhomogeneous index profiles pose several degrees of challenges to thin-film researchers depending upon the availability of relevant experimental and process-monitoring-related information. In the present work, a variety of novel experimental non-linear index profiles have been observed in thin films of MgOAl2O3ZrO2 ternary composites in solid solution under various electron-beam deposition parameters. Analysis and derivation of these non-linear spectral index profiles have been carried out by an inverse-synthesis approach using a real-time optical monitoring signal and post-deposition transmittance and reflection spectra. Most of the non-linear index functions are observed to fit polynomial equations of order seven or eight very well. In this paper, the application of such a non-linear index function has also been demonstrated in designing electric-field-optimized high-damage-threshold multilayer coatings such as normal- and oblique-incidence edge filters and a broadband beam splitter for p-polarized light. Such designs can also advantageously maintain the microstructural stability of the multilayer structure due to the low stress factor of the non-linear ternary composite layers.

The fluid-dynamics of bubble-bearing magmas

NASA Astrophysics Data System (ADS)

colucci, simone; papale, paolo; montagna, chiara

2014-05-01

The rheological properties of a fluid establish how the shear stress, τ, is related to the shear strain-rate, γ . The simplest constitutive equation is represented by the linear relationship τ = μγ, where the viscosity parameter, μ, is independent of strain-rate and the velocity profile is parabolic. Fluids with such a flow curve are called Newtonian. Many fluids, though, exhibit non-Newtonian rheology, typically arising in magmas from the presence of a dispersed phase of either crystals or bubbles. In this case it is not possible to define a strain-rate-independent viscosity and the velocity profile is complex. In this work we extend the 1D, steady, isothermal, multiphase non-homogeneous magma ascent model of Papale (2001) to 1.5D including the Non-Newtonian rheology of the bubble-bearing magma. We describe such rheology in terms of an apparent viscosity, η, which is the ratio of stress to strain-rate (η = τ/γ) and varies with strain-rate across the conduit radius. In this way we calculate a depth-dependent Non-newtonian velocity profile across the radius along with shear strain-rate and viscosity distributions. The evolution of the velocity profile can now be studied in order to investigate processes which occur close to the conduit wall, such as fragmentation. Moreover, the model can quantify the effects of the Non-Newtonian rheology on conduit flow dynamics, in terms of flow variables (e.g. velocity, pressure).

UV-resonance Raman spectroscopy of amino acids

NASA Astrophysics Data System (ADS)

Höhl, Martin; Meinhardt-Wollweber, Merve; Schmitt, Heike; Lenarz, Thomas; Morgner, Uwe

2016-03-01

Resonant enhancement of Raman signals is a useful method to increase sensitivity in samples with low concentration such as biological tissue. The investigation of resonance profiles shows the optimal excitation wavelength and yields valuable information about the molecules themselves. However careful characterization and calibration of all experimental parameters affecting quantum yield is required in order to achieve comparability of the single spectra recorded. We present an experimental technique for measuring the resonance profiles of different amino acids. The absorption lines of these molecules are located in the ultraviolet (UV) wavelength range. One limitation for broadband measurement of resonance profiles is the limited availability of Raman filters in certain regions of the UV for blocking the Rayleigh scattered light. Here, a wavelength range from 244.8 nm to 266.0 nm was chosen. The profiles reveal the optimal wavelength for recording the Raman spectra of amino acids in aqueous solutions in this range. This study provides the basis for measurements on more complex molecules such as proteins in the human perilymph. The composition of this liquid in the inner ear is essential for hearing and cannot be analyzed non-invasively so far. The long term aim is to implement this technique as a fiber based endoscope for non-invasive measurements during surgeries (e. g. cochlear implants) making it available as a diagnostic tool for physicians. This project is embedded in the interdisciplinary cluster of excellence "Hearing for all" (H4A).

Quantitative analysis of three-dimensional biological cells using interferometric microscopy

NASA Astrophysics Data System (ADS)

Shaked, Natan T.; Wax, Adam

2011-06-01

Live biological cells are three-dimensional microscopic objects that constantly adjust their sizes, shapes and other biophysical features. Wide-field digital interferometry (WFDI) is a holographic technique that is able to record the complex wavefront of the light which has interacted with in-vitro cells in a single camera exposure, where no exogenous contrast agents are required. However, simple quasi-three-dimensional holographic visualization of the cell phase profiles need not be the end of the process. Quantitative analysis should permit extraction of numerical parameters which are useful for cytology or medical diagnosis. Using a transmission-mode setup, the phase profile represents the multiplication between the integral refractive index and the thickness of the sample. These coupled variables may not be distinct when acquiring the phase profiles of dynamic cells. Many morphological parameters which are useful for cell biologists are based on the cell thickness profile rather than on its phase profile. We first overview methods to decouple the cell thickness and its refractive index using the WFDI-based phase profile. Then, we present a whole-cell-imaging approach which is able to extract useful numerical parameters on the cells even in cases where decoupling of cell thickness and refractive index is not possible or desired.

Understanding Drug Release Data through Thermodynamic Analysis.

PubMed

Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda E; Genre, Julieta; Oliveira, Anselmo Gomes de; Egito, Eryvaldo Sócrates Tabosa do

2017-06-13

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas-Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability.

Understanding Drug Release Data through Thermodynamic Analysis

PubMed Central

Freire, Marjorie Caroline Liberato Cavalcanti; Alexandrino, Francisco; Marcelino, Henrique Rodrigues; Picciani, Paulo Henrique de Souza; Silva, Kattya Gyselle de Holanda e; Genre, Julieta; de Oliveira, Anselmo Gomes; do Egito, Eryvaldo Sócrates Tabosa

2017-01-01

Understanding the factors that can modify the drug release profile of a drug from a Drug-Delivery-System (DDS) is a mandatory step to determine the effectiveness of new therapies. The aim of this study was to assess the Amphotericin-B (AmB) kinetic release profiles from polymeric systems with different compositions and geometries and to correlate these profiles with the thermodynamic parameters through mathematical modeling. Film casting and electrospinning techniques were used to compare behavior of films and fibers, respectively. Release profiles from the DDSs were performed, and the mathematical modeling of the data was carried out. Activation energy, enthalpy, entropy and Gibbs free energy of the drug release process were determined. AmB release profiles showed that the relationship to overcome the enthalpic barrier was PVA-fiber > PVA-film > PLA-fiber > PLA-film. Drug release kinetics from the fibers and the films were better fitted on the Peppas–Sahlin and Higuchi models, respectively. The thermodynamic parameters corroborate these findings, revealing that the AmB release from the evaluated systems was an endothermic and non-spontaneous process. Thermodynamic parameters can be used to explain the drug kinetic release profiles. Such an approach is of utmost importance for DDS containing insoluble compounds, such as AmB, which is associated with an erratic bioavailability. PMID:28773009

Vector magnetic fields in sunspots. I - Stokes profile analysis using the Marshall Space Flight Center magnetograph

NASA Technical Reports Server (NTRS)

Balasubramaniam, K. S.; West, E. A.

1991-01-01

The Marshall Space Flight Center (MSFC) vector magnetograph is a tunable filter magnetograph with a bandpass of 125 mA. Results are presented of the inversion of Stokes polarization profiles observed with the MSFC vector magnetograph centered on a sunspot to recover the vector magnetic field parameters and thermodynamic parameters of the spectral line forming region using the Fe I 5250.2 A spectral line using a nonlinear least-squares fitting technique. As a preliminary investigation, it is also shown that the recovered thermodynamic parameters could be better understood if the fitted parameters like Doppler width, opacity ratio, and damping constant were broken down into more basic quantities like temperature, microturbulent velocity, or density parameter.

Ion beams extraction and measurements of plasma parameters on a multi-frequencies microwaves large bore ECRIS with permanent magnets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nozaki, Dai; Kiriyama, Ryutaro; Takenaka, Tomoya

2012-11-06

We have developed an all-permanent magnet large bore electron cyclotron resonance ion source (ECRIS) for broad ion beam processing. The cylindrically comb-shaped magnetic field configuration is adopted for efficient plasma production and good magnetic confinement. To compensate for disadvantages of fixed magnetic configuration, a traveling wave tube amplifier (TWTA) is used. In the comb-shaped ECRIS, it is difficult to achieve controlling ion beam profiles in the whole inside the chamber by using even single frequency-controllable TWTA (11-13GHz), because of large bore size with all-magnets. We have tried controlling profiles of plasma parameters and then those of extracted ion beams bymore » launching two largely different frequencies simultaneously, i.e., multi-frequencies microwaves. Here we report ion beam profiles and corresponding plasma parameters under various experimental conditions, dependence of ion beams against extraction voltages, and influence of different electrode positions on the electron density profile.« less

Motion-free hybrid design laser beam propagation analyzer using a digital micromirror device and a variable focus liquid lens.

PubMed

Sheikh, Mumtaz; Riza, Nabeel A

2010-06-01

To the best of our knowledge, we propose the first motion-free laser beam propagation analyzer with a hybrid design using a digital micromirror device (DMD) and a liquid electronically controlled variable focus lens (ECVFL). Unlike prior analyzers that require profiling the beam at multiple locations along the light propagation axis, the proposed analyzer profiles the beam at the same plane for multiple values of the ECVFL focal length, thus eliminating beam profiler assembly motion. In addition to measuring standard Gaussian beam parameters, the analyzer can also be used to measure the M(2) beam propagation parameter of a multimode beam. Proof-of-concept beam parameter measurements with the proposed analyzer are successfully conducted for a 633 nm laser beam. Given the all-digital nature of the DMD-based profiling and all-analog motion-free nature of the ECVFL beam focus control, the proposed analyzer versus prior art promises better repeatability, speed, and reliability.

A family of models for spherical stellar systems

NASA Technical Reports Server (NTRS)

Tremaine, Scott; Richstone, Douglas O.; Byun, Yong-Ik; Dressler, Alan; Faber, S. M.; Grillmair, Carl; Kormendy, John; Lauer, Tod R.

1994-01-01

We describe a one-parameter family of models of stable sperical stellar systems in which the phase-space distribution function depends only on energy. The models have similar density profiles in their outer parts (rho propotional to r(exp -4)) and central power-law density cusps, rho proportional to r(exp 3-eta), 0 less than eta less than or = 3. The family contains the Jaffe (1983) and Hernquist (1990) models as special cases. We evaluate the surface brightness profile, the line-of-sight velocity dispersion profile, and the distribution function, and discuss analogs of King's core-fitting formula for determining mass-to-light ratio. We also generalize the models to a two-parameter family, in which the galaxy contains a central black hole; the second parameter is the mass of the black hole. Our models can be used to estimate the detectability of central black holes and the velocity-dispersion profiles of galaxies that contain central cusps, with or without a central black hole.

Diagnostics, Control and Performance Parameters for the BELLA High Repetition Rate Petawatt Class Laser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nakamura, Kei; Mao, Hann-Shin; Gonsalves, Anthony J.

A laser system producing controllable and stable pulses with high power and ultrashort duration at high repetition rate is a key component of a high energy laser-plasma accelerator (LPA). Precise characterization and control of laser properties are essential to understanding laser-plasma interactions required to build a 10-GeV class LPA. This study discusses the diagnostics, control and performance parameters of a 1 Hz, 1 petawatt (PW) class laser at the Berkeley Lab Laser Accelerator (BELLA) facility. The BELLA PW laser provided up to 46 J on target with a 1% level energy fluctuation and 1.3-μrad pointing stability. The spatial profile wasmore » measured and optimized by using a camera, wavefront sensor, and deformable mirror (ILAO system). The focus waist was measured to be r 0 = 53 μm and the fraction of energy within the circular area defined by the first minimum of the diffraction pattern (r = 67 μm) was 0.75. The temporal profile was controlled via the angle of incidence on a stretcher and a compressor, as well as an acousto-optic programmable dispersive. The temporal pulse shape was measured to be about 33 fs in full width at half maximum (WIZZLER and GRENOUILLE diagnostics). In order to accurately evaluate peak intensity, the energy-normalized peak fluence, and energy-normalized peak power were analyzed for the measured spatial and temporal mode profiles, and were found to be 15 kJ/(cm 2 J) with 6% fluctuation (standard deviation) and 25 TW/J with 5% fluctuation for 46-J on-target energy, respectively. This yielded a peak power of 1.2 PW and a peak intensity of 17×10 18 W/cm 2 with 8% fluctuation. A method to model the pulse shape for arbitrary compressor grating distance with high accuracy was developed. The pulse contrast above the amplified spontaneous emission pedestal was measured by SEQUOIA and found to be better than 10 9. The first order spatiotemporal couplings (STCs) were measured with GRENOUILLE, and a simulation of the pulse's evolution at the vicinity of the target was presented. A maximum pulse front tilt angle of less than 7 mrad was achieved. The reduction of the peak power caused by the first order STCs was estimated to be less than 1%. Finally, the capabilities described in this paper are essential for generation of high quality electron beams.« less