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Sample records for organics fy1995 progress

  1. Organic analysis and analytical methods development: FY 1995 progress report

    SciTech Connect

    Clauss, S.A.; Hoopes, V.; Rau, J.

    1995-09-01

    This report describes the status of organic analyses and developing analytical methods to account for the organic components in Hanford waste tanks, with particular emphasis on tanks assigned to the Flammable Gas Watch List. The methods that have been developed are illustrated by their application to samples obtained from Tank 241-SY-103 (Tank 103-SY). The analytical data are to serve as an example of the status of methods development and application. Samples of the convective and nonconvective layers from Tank 103-SY were analyzed for total organic carbon (TOC). The TOC value obtained for the nonconvective layer using the hot persulfate method was 10,500 {mu}g C/g. The TOC value obtained from samples of Tank 101-SY was 11,000 {mu}g C/g. The average value for the TOC of the convective layer was 6400 {mu}g C/g. Chelator and chelator fragments in Tank 103-SY samples were identified using derivatization. gas chromatography/mass spectrometry (GC/MS). Organic components were quantified using GC/flame ionization detection. Major components in both the convective and nonconvective-layer samples include ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), succinic acid, nitrosoiminodiacetic acid (NIDA), citric acid, and ethylenediaminetriacetic acid (ED3A). Preliminary results also indicate the presence of C16 and C18 carboxylic acids in the nonconvective-layer sample. Oxalic acid was one of the major components in the nonconvective layer as determined by derivatization GC/flame ionization detection.

  2. Advanced organic analysis and analytical methods development: FY 1995 progress report. Waste Tank Organic Safety Program

    SciTech Connect

    Wahl, K.L.; Campbell, J.A.; Clauss, S.A.

    1995-09-01

    This report describes the work performed during FY 1995 by Pacific Northwest Laboratory in developing and optimizing analysis techniques for identifying organics present in Hanford waste tanks. The main focus was to provide a means for rapidly obtaining the most useful information concerning the organics present in tank waste, with minimal sample handling and with minimal waste generation. One major focus has been to optimize analytical methods for organic speciation. Select methods, such as atmospheric pressure chemical ionization mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry, were developed to increase the speciation capabilities, while minimizing sample handling. A capillary electrophoresis method was developed to improve separation capabilities while minimizing additional waste generation. In addition, considerable emphasis has been placed on developing a rapid screening tool, based on Raman and infrared spectroscopy, for determining organic functional group content when complete organic speciation is not required. This capability would allow for a cost-effective means to screen the waste tanks to identify tanks that require more specialized and complete organic speciation to determine tank safety.

  3. Hydrologic resources management program. FY 1995 progress report

    SciTech Connect

    Smith, D.K.; Esser, B.K.; Kenneally, J.M.

    1996-03-01

    This report presents the results of FY 1995 technical studies conducted by the Lawrence Livermore National Laboratory (LLNL) as part of the Hydrology and Radionuclide Migration Program (HRMP), a multi-agency program sponsored by the U.S. Department of Energy, Nevada Operations Office (DOE/NV), to address the environmental consequences of nuclear weapons testing at the Nevada Test Site (NTS). A priority is to better characterize the complex near-field environment in order to assess and predict the movement of radionuclides in groundwater. Other participating organizations include the Los Alamos National Laboratory (LANL), the U.S. Geological Survey (USGS) and the Desert Research Institute (DRI) of the University of Nevada. A radiologic source term in excess of 10{sup 8} curies of tritium, fission products, activation products and actinides is residual from more than three decades of underground nuclear weapons testing at the Nevada Test Site (NTS). Burial depths to insure containment of these explosions necessitated firing approximately one third of the more than 800 underground nuclear tests within one cavity radius or below the static water table. Work at LLNL has focused on studies of radionuclide transport under saturated, partially saturated or unsaturated conditions as well as investigations of the stable, radiogenic and cosmogenic isotope systematics of NTS groundwaters. LLNL has prioritized these studies because of the significance for potential radionuclide migration at the Nevada Test Site. LLNL utilizes expertise in nuclear weapons testing, radiochemical diagnostics, nuclear test phenomenology, mass spectrometry, aqueous geochemistry and field and laboratory studies of radionuclide migration to bring a unique measurement and interpretative capability to this research.

  4. Advanced Industrial Materials (AIM) Program: Annual progress report FY 1995

    SciTech Connect

    1996-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This Annual Report for FY 1995 contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Areas covered here are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

  5. A descriptive model of the molten salt reactor experiment after shutdown: Review of FY 1995 progress

    SciTech Connect

    Williams, D.F.; Del Cul, G.D.; Toth, L.M.

    1996-01-01

    During FY 1995 considerable progress was made toward gaining a better understanding of the chemistry and transport processes that continue to govern the behavior of the Molten Salt Reactor Experiment (MSRE). As measurements in the MSRE proceed, laboratory studies continue, and better analyses are available, our understanding of the state of the MSRE and the best path toward remediation improves. Because of the immediate concern about the deposit in the auxiliary charcoal bed (ACB), laboratory studies in the past year focused on carbon-fluorine chemistry. Secondary efforts were directed toward investigation of gas generation from MSRE salts by both radiolytic and nonradiolytic pathways. In addition to the laboratory studies, field measurements at the MSRE provided the basis for estimating the inventory of uranium and fluorine in the ACB. Analysis of both temperature and radiation measurements provided independent and consistent estimates of about 2.6 kg of uranium deposited in the top of the ACB. Further analysis efforts included a refinement in the estimates of the fuel- salt source term, the deposited decay energy, and the projected rate of radiolytic gas generation. This report also provides the background material necessary to explain new developments and to review areas of particular interest. The detailed history of the MSRE is extensively documented and is cited where appropriate. This work is also intended to update and complement the more recent MSRE assessment reports.

  6. Defense Information Services Organization FY 1995 Budget Estimates Information Technology Systems Budget (Exhibits 43)

    DTIC Science & Technology

    1994-02-01

    communicatons 7 EXHIBIT 43C (change 11 FEBRUARY 1994 U I DEPARTMENT OF DEFENSE DEFENSE INFORMATION SYSTEMS AGENCY DEFENSE INFORMATION SERVICES...threshold in FY 1993 and $25,000 expense/investment threshold for FY 1994 and FY 1995. (2) Includes voice and data communicatons EXHIBIT 43C i FEBRUARY 1994...I Desktop Computer Companion 22 I Desktop IV 23 Electronic Data Corporation 24 Electronic Data Systems 25 Lapheld II 26 Material Management

  7. FY 1995 progress report on the ANS thermal-hydraulic test loop operation and results

    SciTech Connect

    Siman-Tov, M.; Felde, D.K.; Farquharson, G.; McDuffee, J.L.; McFee, M.T.; Ruggles, A.E.; Wendel, M.W.; Yoder, G.L.

    1997-07-01

    The Thermal-Hydraulic Test Loop (THTL) is an experimental facility constructed to support the development of the Advanced Neutron Source Reactor (ANSR) at Oak Ridge National Laboratory (ORNL). The THTL facility was designed and built to provide known thermal-hydraulic (T/H) conditions for a simulated full-length coolant subchannel of the ANS reactor core, thus facilitating experimental determination of FE and CHF thermal limits under expected ANSR T/H conditions. Special consideration was given to allow operation of the system in a stiff mode (constant flow) and in a soft mode (constant pressure drop) for proper implementation of true FE and DNB experiments. The facility is also designed to examine other T/H phenomena, including onset of incipient boiling (IB), single-phase heat transfer coefficients and friction factors, and two-phase heat transfer and pressure drop characteristics. Tests will also be conducted that are representative of decay heat levels at both high pressure and low pressure as well as other quasi-equilibrium conditions encountered during transient scenarios. A total of 22 FE tests and 2 CHF tests were performed during FY 1994 and FY 1995 with water flowing vertically upward. Comparison of these data as well as extensive data from other investigators led to a proposed modification to the Saha and Zuber correlation for onset of significant void (OSV), applied to FE prediction. The modification takes into account a demonstrated dependence of the OSV or FE thermal limits on subcooling levels, especially in the low subcooling regime.

  8. FY 1995 cost savings report

    SciTech Connect

    Andrews-Smith, K.L., Westinghouse Hanford

    1996-06-21

    Fiscal Year (FY) 1995 challenged us to dramatically reduce costs at Hanford. We began the year with an 8 percent reduction in our Environmental Management budget but at the same time were tasked with accomplishing additional workscope. This resulted in a Productivity Challenge whereby we took on more work at the beginning of the year than we had funding to complete. During the year, the Productivity Challenge actually grew to 23 percent because of recissions, Congressional budget reductions, and DOE Headquarters actions. We successfully met our FY 1995 Productivity Challenge through an aggressive cost reduction program that identified and eliminated unnecessary workscope and found ways to be more efficient. We reduced the size of the workforce, cut overhead expenses, eliminated paperwork, cancelled construction of new facilities, and reengineered our processes. We are proving we can get the job done better and for less money at Hanford. DOE`s drive to do it ``better, faster, cheaper`` has led us to look for more and larger partnerships with the private sector. The biggest will be privatization of Hanford`s Tank Waste Remediation System, which will turn liquid tank waste into glass logs for eventual disposal. We will also save millions of dollars and avoid the cost of replacing aging steam plants by contracting Hanford`s energy needs to a private company. Other privatization successes include the Hanford Mail Service, a spinoff of advanced technical training, low level mixed waste thermal treatment, and transfer of the Hanford Museums of Science and history to a private non-profit organization. Despite the rough roads and uncertainty we faced in FY 1995, less than 3 percent of our work fell behind schedule, while the work that was performed was completed with an 8.6 percent cost under-run. We not only met the FY 1995 productivity challenge, we also met our FY 1995-1998 savings commitments and accelerated some critical cleanup milestones. The challenges continue

  9. Tank Focus Area Pretreatment Program. FY 1995 Program Management Plan

    SciTech Connect

    Morrison, M.I.; McGinnis, C.P.; Wilkenson, W.T.; Hunt, R.D.

    1995-02-01

    This program management plan (PMP) describes the FY 1995 project plans for the Pretreatment Program of the Tank Focus Area. The Tank Focus Area is one of five areas of environmental concerns originally identified by the Deputy Assistant Secretary for Technology Development (EM-50). Projects in the Tank Focus Area relate to the remediation of liquid waste stored in underground storage tanks at various US Department of Energy sites. The Pretreatment Program is an organizational unit performing work within the Tank Focus Area. The function of the Pretreatment Program is to develop, test, evaluate, and demonstrate new technologies, with emphasis on separations. The 11 Pretreatment Program projects for FY 1995 are (1) Cesium Extraction Testing, (2) Comprehensive Supernate Treatment, (3) Hot Cell Studies, (4) Cesium Removal Demonstration, (5) Out-of-Tank Evaporator Demonstration, (6) Crossflow Filtration, (7) Technical Interchange with CEA, (8) TRUEX Applications, (9) NAC/NAG Process Studies (conducted at Oak Ridge National Laboratory), (10) NAC/NAG Process and Waste Form Studies (conducted at Florida International University), and (11) Program Management. Section 2 of this PMP contains a separate subsection for each FY 1995 project. A brief description of the project, a schedule of major milestones, and a breakdown of costs are provided for each project. The PMP also contains sections that describe the project controls that are in place. Quality assurance, document control, the project management system, and the management organization are described in these sections.

  10. Biological and chemical technologies research. FY 1995 annual summary report

    SciTech Connect

    1996-03-01

    The annual summary report presents the fiscal year (FY) 1995 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program. This BCTR program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1995 (ASR 95) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1995; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents; and awards arising from work supported by the BCTR.

  11. Advanced energy projects; FY 1995 research summaries

    SciTech Connect

    1995-09-01

    The AEP Division supports projects to explore novel energy-related concepts which are typically at an early stage of scientific development, and high-risk, exploratory concepts. Topical areas presently receiving support are: novel materials for energy technology, renewable and biodegradable materials, exploring uses of new scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, and innovative approaches to waste treatment and reduction. There were 46 research projects during FY 1995; ten were initiated during that fiscal year. The summaries are separated into grant and laboratory programs, and small business innovation research programs.

  12. Trace gas concentrator FY 1995 summary report

    SciTech Connect

    Andriulli, J.B.; Szady, A.J. Jr.

    1996-05-01

    This report summarizes the accomplishments of the Trace Gas Concentrator Technology Demonstration Project during FY 1995 and through February 1996. The purpose of the activity was to demonstrate proof of principle of a system that concentrates airborne substances (e.g., chemical agents, explosives, narcotics and their precursors, and pollutants) to aid in their detection. A comprehensive computer model (initiated in FY 1994) was developed for the theoretical prediction of the fluid dynamics and mass concentration of the trace gas concentrator. The gas test stand has been installed and checked out. An automated computer data acquisition system has been installed and connected to the concentrator test stand. The data acquisition system is needed to record gas and mechanical operations.

  13. High performance computing and communications: FY 1995 implementation plan

    SciTech Connect

    1994-04-01

    The High Performance Computing and Communications (HPCC) Program was formally established following passage of the High Performance Computing Act of 1991 signed on December 9, 1991. Ten federal agencies in collaboration with scientists and managers from US industry, universities, and laboratories have developed the HPCC Program to meet the challenges of advancing computing and associated communications technologies and practices. This plan provides a detailed description of the agencies` HPCC implementation plans for FY 1994 and FY 1995. This Implementation Plan contains three additional sections. Section 3 provides an overview of the HPCC Program definition and organization. Section 4 contains a breakdown of the five major components of the HPCC Program, with an emphasis on the overall directions and milestones planned for each one. Section 5 provides a detailed look at HPCC Program activities within each agency. Although the Department of Education is an official HPCC agency, its current funding and reporting of crosscut activities goes through the Committee on Education and Health Resources, not the HPCC Program. For this reason the Implementation Plan covers nine HPCC agencies.

  14. Department of Defense Manpower Requirements Report FY 1995

    DTIC Science & Technology

    1994-05-01

    SECDEF’s Bottom-Up Review of Defense Needs and Programs while addressing requirements stretching beyond today’s programs. The Air Force has continued...typically manned below 100 percent. In time of crisis, these forces will be augmented by realigning Active Component assets or using pre -trained manpower...174,000 was submitted for FY 1995. 2. Proae- Kannoe BtLre and ProSrrutaed KMin a. Proarammed Mannower Structure. Proarammed Manning. andEnd_ Stregth

  15. Photovoltaics program plan, FY 1991--FY 1995

    SciTech Connect

    Not Available

    1991-10-01

    This program plan describes the goals and philosophy of DOE National Photovoltaics Program and its major research and development activities for fiscal years (FY) 1991 through 1995. The plan represents a consensus among researchers and manufacturers, as well as current and potential users of photovoltaics (PV). It defines the activites that we believe are necessary to continue the rapid progress toward acceptance of photovoltaics as a serious candidate for cost-competitive electric power generation by the utility, transportation, buildings, and industrial sectors. A succesful National Photovoltaics Program will help achieve many of our national priorities. The mission of the National Photovoltaics Program is to help US industry to develop photovoltaic technology for large-scale generation of economically competitive electric power in the United States, making PV a significant part of our national energy mix. To fully achieve this, we must continue to work toward the long-term goals established in our previous program plan: reducing the price of delivered electricity to 5 to 6 cents per kilowatt-hour (kWh), increasing lifetimes to 30 years, and increasing module efficiencies to 15% for flat-plate and 25% for concentrator technologies. If progress continues at its current pace, we expect that the PV industry will have installed at least 1000 megawatts (MW) of capacity in the United States and 500 MW internationally by the year 2000.

  16. Laboratory directed research and development. FY 1995 progress report

    SciTech Connect

    Vigil, J.; Prono, J.

    1996-03-01

    This document presents an overview of Laboratory Directed Research and Development Programs at Los Alamos. The nine technical disciplines in which research is described include materials, engineering and base technologies, plasma, fluids, and particle beams, chemistry, mathematics and computational science, atmic and molecular physics, geoscience, space science, and astrophysics, nuclear and particle physics, and biosciences. Brief descriptions are provided in the above programs.

  17. Summary of research for FY-1995: Progress report

    SciTech Connect

    Brasseur, G.; Erickson, D.; Tie, X.X.; Walters, S.

    1996-03-01

    The object of this proposal is to study the reduction in mid-latitude stratospheric ozone and to estimate the budget of tropospheric ozone. The product of this proposal include: (1) the estimation of dilution of air masses processed by polar stratospheric clouds inside the polar vortex during winter; and (2) the destruction of ozone via heterogeneous reactions on the surface of aerosol particles which are present at all latitudes, especially after large volcanic eruptions such as Mt. Pinatubo; (3) to quantify photochemical production and destruction of O{sub 3} in the free troposphere; (4) to quantify export of ozone from polluted to remote regions, and (5) to quantify cross-tropopause exchanges of O{sub 3} and other species. The approach of this proposal is to use and to improve the two-dimensional and three-dimensional global chemical/dynamical models.

  18. ORNL Superconducting Technology Program for electric power systems. Annual report for FY 1995

    SciTech Connect

    Hawsey, R.A.; Turner, J.W.

    1996-05-01

    The Oak Ridge National Laboratory (ORNL) Superconducting Technology Program is conducted as part of a national effort by the U.S. Department of Energy`s Office of Energy Efficiency and Renewable Energy to develop the science and technology base needed by U.S. industry for commercial development of electric power applications of high-temperature superconductivity. The two major elements of this program are wire development and systems development. This document describes the major research and development activities for this program together with related accomplishments. The technical progress reported was summarized from information prepared for the FY 1995 Annual Program Review held August 1-2, 1995. This ORNL program is highly leveraged by the staff and other resources of U.S. industry and universities. In fact, nearly three-fourths of the ORNL effort is devoted to cooperative projects with private companies. Interlaboratory teams are also in place on a number of industry-driven projects. Patent disclosures, working group meetings, staff exchanges, and joint publications and presentations ensure that there is technology transfer with U.S. industry. Working together, the collaborative teams are making rapid progress in solving the scientific and technical issues necessary for the commercialization of long lengths of practical high-temperature superconductor wire and wire-using systems.

  19. Microgravity science & applications. Program tasks and bibliography for FY 1995

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This annual report includes research projects funded by the Office of Life and Microgravity Sciences and Applications, Microgravity Science and Applications Division, during FY 1994. It is a compilation of program tasks (objective, description, significance, progress, students funded under research, and bibliographic citations) for flight research and ground based research in five major scientific disciplines: benchmark science, biotechnology, combustion science, fluid physics, and materials science. Advanced technology development (ATD) program task descriptions are also included. The bibliography cites the related principle investigator (PI) publications and presentations for these program tasks in FY 1994. Three appendices include a Table of Acronyms, a Guest Investigator index and a Principle Investigator index.

  20. Program status. 2nd quarter - FY 1995. Confinement systems programs

    SciTech Connect

    1995-04-18

    We conducted physics experiments: record normalized {Beta} = 4.9 achieved in VH-mode, {Beta} limits of ITER-like configurations evaluated, FWCD commissioning. The tokamak vessel was opened to atmosphere for six weeks and a number of key diagnostics for understanding the divertor were installed. The DIII-D Advisory Committee met in January to review the DIII-D program and plan. They commended us for recent progress and supported the vanadium divertor design. The U.S./Japan DIII-D steering committee met and recommended extending the agreement to the year 2000. The field work proposal for FY 96/97 was presented in Washington on March 29, 1995. A review of the DIII-D plan to install vanadium structural components as part of the new radiative divertor modification was held in Washington 31, 1995 and the panel endorsed the plans. Preliminary plans were developed with PPPL for collaborations in FY96,

  1. Hanford prototype-barrier status report: FY 1995

    SciTech Connect

    Gee, G.W.; Ward, A.L.; Gilmore, B.G.; Ligotke, M.W.; Link, S.O.

    1995-11-01

    Surface barriers (or covers) have been proposed for use at the Hanford Site as a means to isolate certain waste sites that, for reasons of cost or worker safety or both, may not be exhumed. Surface barriers are intende to isolated the wastes from the accessible environment and to provide long-term protection to future populations that might use the Hanford Site. Currently, no ``proven`` long-term barrier system is available. For this reason, the Hanford Site Permanent Isolation Surface-Barrier Development Program (BDP) was organized to develop the technology needed to provide long-term surface barrier capability for the Hanford Site for the US Department of Energy (DOE). Designs have been proposed to meet the most stringent needs for long-term waste disposal. The objective of the current barrier design is to use natural materials to develop a protective barrier system that isolates wastes for at least 1000 years by limiting water, plant, animal, and human intrusion; and minimizing erosion. The design criteria for water drainage has been set at 0.5 mm/yr. While other design criteria are more qualitative, it is clear that waste isolation for an extended time is the prime objective of the design. Constructibility and performance. are issues that can be tested and dealt with by evaluating prototype designs prior to extensive construction and deployment of covers for waste sites at Hanford.

  2. FY 1995 separation studies for liquid low-level waste treatment at Oak Ridge National Laboratory

    SciTech Connect

    Bostick, D.T.; Arnold, W.D.; Burgess, M.W.

    1995-01-01

    During FY 1995, studies were continued to develop improved methods for centralized treatment of liquid low-level waste (LLLW) at Oak Ridge National Laboratory (ORNL). Focus in this reporting period was on (1) identifying the parameters that affect the selective removal of {sup 90}Sr and {sup 137}Cs, two of the principal radioactive contaminants expected in the waste; (2) validating the effectiveness of the treatment methods by testing an ac Melton Valley Storage Tank (MVST) supernate; (3) evaluating the optimum solid/liquid separation techniques for the waste; (4) identifying potential treatment methods for removal of technetium from LLLW; and (5) identifying potential methods for stabilizing the high-activity secondary solid wastes generated by the treatment.

  3. Department of the Navy FY 1995 Budget Estimates. Justification of Estimates, Research, Development, Test and Evaluation, Navy Descriptive Summaries

    DTIC Science & Technology

    1994-02-01

    original copy. This document contains blank pages that were not filmed NAVY RDT&E PROGRAM ELEMENT DESCRIPTIVE SUMMARIES INTRODUCTION AND KIPLANATION OF...CONTENTS 1. general. This document has been prepared to provide information on the Department of the Navy Research, Development, Test and Evaluation...Program to Congressional committees during the FY 1995 hearings. The Descriptive Summaries provide narrative information on all non-special access Navy RDT

  4. Defense Business Operations Fund, Navy. FY 1995 Budget Estimates Operating and Capital Budgets

    DTIC Science & Technology

    1994-02-01

    material surcharge. 0057 LOGISTICS SUPPORT ACTIITIES.- NAVY REVENUE AD EXPENSES (Doll.s in Milns) FY*193 FY 104 FY 1995 Revemue Gram Saele Operons 0.0 0.0...1_=w I i ~s -.II l.• II I RI s- I 1 ", I so Is I , I a a __I oI• I ,- c S 5 a I a a0 laC ’ ;4 L 1 46 I 3I I C0 I *cI I-ce ~0 I• . I I•i I aI."I I...A . Lee -,Cv SWSV90S C 316 a uC v-4SM azuI I z US.Cmw0OOvLauaw ft0 vMUSvq3J.005I V30 go V U I :MUSat 41LaUS- -- 0 6ua5 u a-4 0C C Ilz 01 a 04 a 3 EUM

  5. Mechanisms of gas generation from simulated SY tank farm wastes: FY 1995 progress report

    SciTech Connect

    Barefield, E.K.; Boatright, D.; Deshpande, A.; Doctorovich, F.; Liotta, C.L.; Neumann, H.M.; Seymore, S.

    1996-07-01

    The objective of this work is to develop a better understanding of the mechanism of formation of flammable gases in the thermal decomposition of metal complexants such as HEDTA and sodium glycolate in simulated SY tank farm waste mixtures. This report summarizes the results of work done at the Georgia Institute of Technology in fiscal year 1995. Topics discussed are (1) long-term studies of the decomposition of HEDTA in simulated waste mixtures under an argon atmosphere at 90 and 120{degrees}C, including time profiles for disappearance of HEDTA and appearance of products and the quantitative analysis of the kinetic behavior; (2) considerations of hydroxylamine as an intermediate in the production of nitrogen containing gases by HEDTA decomposition; (3) some thoughts on the revision of the global mechanism for thermal decomposition of HEDTA under argon; (4) preliminary long-term studies of the decomposition of HEDTA in simulated waste under an oxygen atmosphere at 120{degrees}C; (5) estimation of the amount of NH{sub 3} in the gas phase above HEDTA reaction mixtures; and (6) further, examination of the interaction of aluminum with nitrite ion using {sup 27}Al NMR spectroscopy. Section 2 of this report describes the work conducted over the last three years at GIT. Section 3 contains a discussion of the kinetic behavior of HEDTA under argon; Section 4 discusses the role of hydroxylamine. Thermal decomposition of HEDTA to ED3A is the subject of Section 5, and decomposition of HEDTA in simulated waste mixtures under oxygen is covered in Section 6. In Section 7 we estimate ammonia in the gas phase; the role of aluminum is discussed in Section 8.

  6. Energy Division progress report, fiscal years 1994--1995

    SciTech Connect

    Moser, C.I.

    1996-06-01

    At ORNL, the Energy Division`s mission is to provide innovative solutions to energy and related issues of national and global importance through interdisciplinary research and development. Its goals and accomplishments are described in this progress report for FY 1994 and FY 1995. The Division`s expenditures in FY 1995 totaled 44.9 million. Sixty percent of the divisions work was supported by the US DOE. Other significant sponsors include the US DOT, the US DOD, other federal agencies, and some private organizations. The Division`s programmatic activities cover three main areas: (1) analysis and assessment, (2) transportation systems, and (3) energy use and delivery technologies. Analysis and assessment activities involve energy and resource analysis, preparation of environmental assessments and impact statements, and impact statements, research on emergency preparedness, analysis of energy and environmental needs in developing countries, and transportation analysis. Transportation systems research seeks to improve the quality of both civilian and military transportation efforts. Energy use and delivery technologies focus on building equipment, building envelopes, (walls, roofs, attics, and materials), improvement of energy efficiency in buildings, and electric power systems.

  7. FY 1995 remedial investigation work plan for Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    SciTech Connect

    Watkins, D.R.; Herbes, S.E.

    1994-09-01

    Field activities to support the remedial investigation (RI) of Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL) include characterization of the nature and extent of contamination in WAG 2, specifically to support risk-based remediation decisions. WAG 2 is the major drainage system downgradient of other WAGs containing significant sources of contamination at ORNL. The RI of WAG 2 is developed in three phases: Phase 1, initial scoping characterization to determine the need for early action; Phase 2, interim activities during remediation of upgradient WAGs to evaluate potential changes in the contamination status of WAG 2 that would necessitate reevaluation of the need for early action; and Phase 3, completion of the RI process following remediation of upslope WAGs. Specifically, Phase 2 activities are required to track key areas to determine if changes have occurred in WAG 2 that would require (1) interim remedial action to protect human health and the environment or (2) changes in remedial action plans and schedules for WAG2 because of changing contaminant release patterns in upslope WAGs or because of the effects of interim remedial or removal actions in other WAGs. This report defines activities to be conducted in FY 1995 for completion of the Phase 1 RI and initiation of limited Phase 2 field work.

  8. Science and Technology Program, FY 1995. Research and Development Program 2.4

    DTIC Science & Technology

    1994-07-01

    of second language acquisition and retention including individual differences in learning style; (b) Identify the major dimensions of second language acquisition and... second language acquisition and retention. PROGRESS: Method for using a parser to create a dynamic student model First generation German language tutor

  9. Waste Tank Vapor Characterization Project: Annual status report for FY 1995

    SciTech Connect

    Ligotke, M.W.; Fruchter, J.S.; Huckaby, J.L.; Birn, M.B.; McVeety, B.D.; Evans, J.C. Jr.; Pool, K.H.; Silvers, K.L.; Goheen, S.C.

    1995-11-01

    This report compiles information collected during the Fiscal Year 1995 pertaining to the waste tank vapor characterization project. Information covers the following topics: project management; organic sampling and analysis; inorganic sampling and analysis; waste tank vapor data reports; and the waste tanks vapor database.

  10. Division of energy biosciences: Annual report and summaries of FY 1995 activities

    SciTech Connect

    1996-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

  11. Chemistry and materials science progress report. Weapons-supporting research and laboratory directed research and development: FY 1995

    SciTech Connect

    1996-04-01

    This report covers different materials and chemistry research projects carried out a Lawrence Livermore National Laboratory during 1995 in support of nuclear weapons programs and other programs. There are 16 papers supporting weapons research and 12 papers supporting laboratory directed research.

  12. Progress in abdominal organ transplantation

    PubMed Central

    Kosieradzki, Maciej; Lisik, Wojciech; Rowiński, Wojciech; Małkowski, Piotr

    2011-01-01

    Summary The excellent results of vascularized organ transplantation have resulted in an increasing number of end-stage organ failure patients seeking such treatment. The results of organ transplantation depend on a number of factors – the quality of the donor (and an organ), living vs. deceased donation, magnitude of ischemic injury (and its prevention), and recipient-dependent factors. Ischemia/reperfusion injury in organ transplantation is a multifactorial process, which may lead to delayed graft function. In addition, surgical and preservation techniques, type of immunosuppressive regimens, complications after transplantation and post-transplant management may also have a significant impact on short- and long-term results of transplantation. In this paper we describe advances in transplantation in recent years, with particular emphasis on kidney, liver, intestines, whole pancreas and pancreatic islets. PMID:22129915

  13. Bioengineering for Organ Transplantation: Progress and Challenges.

    PubMed

    Welman, Ted; Michel, Sebastian; Segaren, Nicholas; Shanmugarajah, Kumaran

    2015-01-01

    Organ transplantation can offer a curative option for patients with end stage organ failure. Unfortunately the treatment is severely limited by the availability of donor organs. Organ bioengineering could provide a solution to the worldwide critical organ shortage. The majority of protocols to date have employed the use of decellularization-recellularization technology of naturally occurring tissues and organs with promising results in heart, lung, liver, pancreas, intestine and kidney engineering. Successful decellularization has provided researchers with suitable scaffolds to attempt cell reseeding. Future work will need to focus on the optimization of organ specific recellularization techniques before organ bioengineering can become clinically translatable. This review will examine the current progress in organ bioengineering and highlight future challenges in the field.

  14. Special initiatives FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP) WBS 5.0

    SciTech Connect

    Jekel, R.A.

    1994-09-01

    The Special Initiatives mission supports programmatic requests for service to DOE offices, other organizations and agencies. These requests can include the following: Supporting priority DOE initiatives; Researching special programs; Studying locating new activities at the Hanford Site; Producing specialty materials; Providing consulting support to other sites; Managing a broad spectrum of US and international test programs.

  15. Current progress in xenotransplantation and organ bioengineering.

    PubMed

    Michel, Sebastian G; Madariaga, Maria Lucia L; Villani, Vincenzo; Shanmugarajah, Kumaran

    2015-01-01

    Organ transplantation represents a unique method of treatment to cure people with end-stage organ failure. Since the first successful organ transplant in 1954, the field of transplantation has made great strides forward. However, despite the ability to transform and save lives, transplant surgery is still faced with a fundamental problem the number of people requiring organ transplants is simply higher than the number of organs available. To put this in stark perspective, because of this critical organ shortage 18 people every day in the United States alone die on a transplant waiting list (U.S. Department of Health & Human Services, http://organdonor.gov/about/data.html). To address this problem, attempts have been made to increase the organ supply through xenotransplantation and more recently, bioengineering. Here we trace the development of both fields, discuss their current status and highlight limitations going forward. Ultimately, lessons learned in each field may prove widely applicable and lead to the successful development of xenografts, bioengineered constructs, and bioengineered xeno-organs, thereby increasing the supply of organs for transplantation.

  16. Gaps and Progress in Our Knowledge of Learning Organizations

    ERIC Educational Resources Information Center

    Tuggle, Francis D.

    2016-01-01

    Purpose: This study aims to review previously published issues of "The Learning Organization" ("TLO") to assess what progress has been made since the journal started in terms of what is known about learning organizations. The author also aims to identify important gaps in what is still to be discovered about organizations that…

  17. Progress in organic integrated circuit manufacture

    NASA Astrophysics Data System (ADS)

    Taylor, D. Martin

    2016-02-01

    This review article focuses on the development of processes for the manufacture of organic electronic circuits. Beginning with the first report of an organic transistor it highlights the key developments leading to the successful manufacture of microprocessors and other complex circuits incorporating organic transistors. Both batch processing (based on silicon integrated circuit technology) as well as mass-printing, roll-to-roll (R2R) approaches are discussed. Currently, the best circuit performances are achieved using batch processing. It is suggested that an emerging, large mass-market for electronic tags may dictate that R2R manufacture will likely be required to meet the high throughput rates needed. However, significant improvements in resolution and registration are necessary to achieve increased circuit operating speeds.

  18. The Progress of Theory in Knowledge Organization.

    ERIC Educational Resources Information Center

    Smiraglia, Richard P.

    2002-01-01

    Presents a background on theory in knowledge organization, which has moved from an epistemic stance of pragmatism and rationalism (based on observation of the construction of retrieval tools), to empiricism (based on the results of empirical research). Discusses historicism, external validity, classification, user-interface design, and…

  19. Organic analysis progress report FY 1997

    SciTech Connect

    Clauss, S.A.; Grant, K.E.; Hoopes, V.; Mong, G.M.; Steele, R.; Bellofatto, D.; Sharma, A.

    1998-04-01

    The Organic Analysis and Methods Development Task is being conducted by Pacific Northwest National Laboratory (PNNL) as part of the Organic Tank Waste Safety Project. The objective of the task is to apply developed analytical methods to identify and/or quantify the amount of particular organic species in tank wastes. In addition, this task provides analytical support for the Gas Generation Studies Task, Waste Aging, and Solubility Studies. This report presents the results from analyses of tank waste samples archived at Pacific Northwest National Laboratory (PNNL) and received from the Project Hanford Management Contractor (PHMC), which included samples associated with both the Flammable Gas and Organic Tank Waste Safety Programs. The data are discussed in Section 2.0. In addition, the results of analytical support for analyzing (1) simulated wastes for Waste Aging, (2) tank waste samples for Gas Generation, and (3) simulated wastes associated with solubility studies discussed in Sections 3.0, 4.0, and 5.0, respectively. The latter part of FY 1997 was devoted to documenting the analytical procedures, including derivation gas chromatography/mass spectrometry (GC/MS) and GC/FID for quantitation, ion-pair chromatography (IPC), IC, and the cation exchange procedure for reducing the radioactivity of samples. The documentation of analytical procedures is included here and discussed in Section 6.0 and Section 7.0 discusses other analytical procedures. The references are listed in Section 8.0 and future plans are discussed in Section 9.0. Appendix A is a preprint of a manuscript accepted for publication. Appendix B contains the cc mail messages and chain-of-custody forms for the samples received for analyses. Appendix C contains the test plan for analysis of tank waste samples.

  20. Removal of strontium and transuranics from Hanford tank waste via addition of metal cations and chemical oxidant: FY 1995 test results

    SciTech Connect

    Orth, R.J.; Zacher, A.H.; Schmidt, A.J.; Elmore, M.R.; Elliott, K.R.; Neuenschwander, G.G.; Gano, S.R.

    1995-09-01

    Chelating organics and some of their degradation products in the Hanford tank waste, such as EDTA, HEDTA, and NTA act to solubilize strontium and transuranics (TRU) in the tank waste supernatant. Displacement of strontium and TRU will facilitate the removal of these radionuclides via precipitation/filtration, ion exchange, or solvent extraction so that low-level waste feed specifications can be met. Pacific Northwest Laboratory has investigated two methods for releasing organic-complexed strontium and TRU components to allow for effective pretreatment of tank waste supernatant: metal cation addition (to promote displacement and flocculation) and chemical oxidant (pennanganate) addition (to promote chelator destruction/defunctionalization and possibly flocculation). These methods, which can be conducted at near-ambient. temperatures and pressures, could be deployed as intank processes.

  1. Summaries of FY 1995 geosciences research

    SciTech Connect

    1995-12-01

    The summaries in this document, prepared by the investigators, describe the scope of the individual programs. The Geosciences Research Program includes research in geophysics, geochemistry, resource evaluation, solar-terrestrial interactions, and their subdivisions including earth dynamics, properties of earth materials, rock mechanics, underground imaging, rock-fluid interactions, continental scientific drilling, geochemical transport, solar/atmospheric physics, and modeling, with emphasis on the interdisciplinary areas. All such research is related either direct or indirect to the Department of Energy`s long-range technological needs.

  2. NREL Photovoltaic Program FY 1995 annual report

    SciTech Connect

    1996-06-01

    This report summarizes the in-house and subcontracted R&D activities from Oct. 1994 through Sept. 1995; their objectives are to conduct basic, applied, and engineering research, manage subcontracted R&D projects, perform research complementary to subcontracted work, develop and maintain state-of-the-art measurement and device capabilities, develop PV manufacturing technology and modules, transfer results to industry, and evolve viable partnerships for PV systems and market development. The research activities are grouped into 5 sections: crystalline Si and advanced devices, thin-film PV, PV manufacturing, PV module and system performance and engineering, and PV applications and market development.

  3. Technology development needs summary, FY 1995

    SciTech Connect

    Not Available

    1994-03-01

    Historic activities of DOE during the period of nuclear weapons development, and disposal practices of that time, resulted in the discharge of chemical and radioactive materials to the environment at many DOE facilities and sites. DOE has now focused a major technical effort on mitigating the effects of those discharges through an environmental restoration program. Since this could lead to prohibitive costs if conventional technology is applied for remedial action, a national program will be initiated to develop and demonstrate faster, better, cheaper, and safer means of restoring the DOE sites to conditions that will meet state and federal environment regulations. Key elements of the initiative are the Integrated Programs and Integrated Demonstrations, which work together to identify possible solutions to major environmental problems. Needed statements are given for the following programs: mixed waste landfill, uranium in soils, VOC-arid, decontamination and decommissioning of facilities, buried waste, characterization/monitoring/sensor technology, mixed waste, in situ remediation, efficient separations/processing, minimum additive waste stabilization, supercritical water oxidation. A section on how to get involved is included.

  4. Summaries of FY 1995 engineering research

    SciTech Connect

    1996-03-01

    The individual engineering project summaries follow the program overview. The summaries are ordered alphabetically by name of institution and so the table of contents lists all the institutions at which projects were sponsored in fiscal year 1995. Each project entry begins with an institutional-departmental heading. The names of investigators are listed immediately below the title. The funding level for fiscal year 1995 appears to the right of title; it is followed by the budget activity number. These numbers categorize the projects for budgetary purposes and the categories are described in the budget number index. A separate index of Principal Investigators includes phone number, fax number and e-mail address, where available. The fiscal year in which either the project began or was renewed and the anticipated duration in years are indicated respectively by the first two and last digits of the sequence directly below the budget activity number. The summary description of the project completes the entry.

  5. Institutional Plan, FY 1995--2000

    SciTech Connect

    1994-10-01

    Sandia recently completed an updated strategic plan, the essence of which is presented in chapter 4. Sandia`s Strategic Plan 1994 takes its direction from DOE`s Fueling a Competitive Economy: Strategic Plan and provides tangible guidance for Sandia`s programs and operations. Although it is impossible to foresee precisely what activities Sandia will pursue many years from now, the strategic plan makes one point clear: the application of our scientific and engineering skills to the stewardship of the nation`s nuclear deterrent will be central to our service to the nation. We will provide the necessary institutional memory and continuity, experience base, and technical expertise to ensure the continued safety, security, and reliability of the nuclear weapons stockpile. As a multiprogram laboratory, Sandia will also continue to focus maximum effort on a broad spectrum of other topics consistent with DOE`s enduring core mission responsibilities: Defense (related to nuclear weapons), Energy, Environment (related to waste management and environmental remediation), and Basic Science.

  6. CRPE: Cesium Return Program Experience FY 1995

    SciTech Connect

    Clements, E.P.

    1995-11-01

    Since 1945, the chemical reprocessing of irradiated nuclear fuels in the Hanford Chemical Separation areas has resulted in the generation of significant volumes of high-level, liquid, radioactive, by-product materials. However, because these materials were recognized to have beneficial uses, their disposal was delayed. To investigate the possibilities, the By-product Utilization Program (BUP) was initiated. The program mission was to develop a means for the application of radioactive-fission products for the benefit of society. Cs capsules were fabricated and distributed to private irradiation facilities for beneficial product sterilization. In June of 1988, a small leak developed in one of the Cs capsules at a private irradiator facility that is located in Decatur, Georgia. This leak prompted DOE to remove these capsules and to re-evaluate the BUP with the irradiator facilities that were currently using Cs capsules. As a result of this evaluation, a recall was issued to require that all remaining Cs capsules be returned to Hanford for safe management and storage pending final capsule disposition. The WHC completed the return of 309 capsules from a private irradiation facility, located in Northglenn, Colorado, to the Hanford Reservation. The DOE is also planning to remove 25 Cs capsules from a small, private irradiator facility located in Lynchburg, Virginia. This small irradiator facility is currently operational and uses the capsules for the underwater irradiation of wood-flooring products. This report discusses transportation-related activities that WHC has researched, developed, implemented, and is currently managing to ensure the safe and efficient movement of Cs-137 back to the Hanford Reservation.

  7. Idaho Public Library Statistics, FY 1995.

    ERIC Educational Resources Information Center

    Bolles, Charles

    This document is a compilation of input and output measures and other statistics in reference to Idaho's public libraries, covering the period October 1, 1994 to September 30, 1995. This report includes data gathered by the State Library with the "Public and District Library Annual Statistical Report Form" which reflects all monies…

  8. Recent progress in photoactive organic field-effect transistors.

    PubMed

    Wakayama, Yutaka; Hayakawa, Ryoma; Seo, Hoon-Seok

    2014-04-01

    Recent progress in photoactive organic field-effect transistors (OFETs) is reviewed. Photoactive OFETs are divided into light-emitting (LE) and light-receiving (LR) OFETs. In the first part, LE-OFETs are reviewed from the viewpoint of the evolution of device structures. Device performances have improved in the last decade with the evolution of device structures from single-layer unipolar to multi-layer ambipolar transistors. In the second part, various kinds of LR-OFETs are featured. These are categorized according to their functionalities: phototransistors, non-volatile optical memories, and photochromism-based transistors. For both, various device configurations are introduced: thin-film based transistors for practical applications, single-crystalline transistors to investigate fundamental physics, nanowires, multi-layers, and vertical transistors based on new concepts.

  9. Recent progress in photoactive organic field-effect transistors

    NASA Astrophysics Data System (ADS)

    Wakayama, Yutaka; Hayakawa, Ryoma; Seo, Hoon-Seok

    2014-04-01

    Recent progress in photoactive organic field-effect transistors (OFETs) is reviewed. Photoactive OFETs are divided into light-emitting (LE) and light-receiving (LR) OFETs. In the first part, LE-OFETs are reviewed from the viewpoint of the evolution of device structures. Device performances have improved in the last decade with the evolution of device structures from single-layer unipolar to multi-layer ambipolar transistors. In the second part, various kinds of LR-OFETs are featured. These are categorized according to their functionalities: phototransistors, non-volatile optical memories, and photochromism-based transistors. For both, various device configurations are introduced: thin-film based transistors for practical applications, single-crystalline transistors to investigate fundamental physics, nanowires, multi-layers, and vertical transistors based on new concepts.

  10. Self-organization of progress across the century of physics

    PubMed Central

    Perc, Matjaž

    2013-01-01

    We make use of information provided in the titles and abstracts of over half a million publications that were published by the American Physical Society during the past 119 years. By identifying all unique words and phrases and determining their monthly usage patterns, we obtain quantifiable insights into the trends of physics discovery from the end of the 19th century to today. We show that the magnitudes of upward and downward trends yield heavy-tailed distributions, and that their emergence is due to the Matthew effect. This indicates that both the rise and fall of scientific paradigms is driven by robust principles of self-organization. Data also confirm that periods of war decelerate scientific progress, and that the later is very much subject to globalisation.

  11. Self-organization of progress across the century of physics

    NASA Astrophysics Data System (ADS)

    Perc, Matjaž

    2013-04-01

    We make use of information provided in the titles and abstracts of over half a million publications that were published by the American Physical Society during the past 119 years. By identifying all unique words and phrases and determining their monthly usage patterns, we obtain quantifiable insights into the trends of physics discovery from the end of the 19th century to today. We show that the magnitudes of upward and downward trends yield heavy-tailed distributions, and that their emergence is due to the Matthew effect. This indicates that both the rise and fall of scientific paradigms is driven by robust principles of self-organization. Data also confirm that periods of war decelerate scientific progress, and that the later is very much subject to globalisation.

  12. Progress on lanthanide-based organic-inorganic hybrid phosphors.

    PubMed

    Carlos, Luís D; Ferreira, Rute A S; de Zea Bermudez, Verónica; Julián-López, Beatriz; Escribano, Purificación

    2011-02-01

    Research on organic-inorganic hybrid materials containing trivalent lanthanide ions (Ln(3+)) is a very active field that has rapidly shifted in the last couple of years to the development of eco-friendly, versatile and multifunctional systems, stimulated by the challenging requirements of technological applications spanning domains as diverse as optics, environment, energy, and biomedicine. This tutorial review offers a general overview of the myriad of advanced Ln(3+)-based organic-inorganic hybrid materials recently synthesised, which may be viewed as a major innovation in areas of phosphors, lighting, integrated optics and optical telecommunications, solar cells, and biomedicine.

  13. Recent progress in the synthesis of metal–organic frameworks

    PubMed Central

    Sun, Yujia; Zhou, Hong-Cai

    2015-01-01

    Metal–organic frameworks (MOFs) have attracted considerable attention for various applications due to their tunable structure, porosity and functionality. In general, MOFs have been synthesized from isolated metal ions and organic linkers under hydrothermal or solvothermal conditions via one-spot reactions. The emerging precursor approach and kinetically tuned dimensional augmentation strategy add more diversity to this field. In addition, to speed up the crystallization process and create uniform crystals with reduced size, many alternative synthesis routes have been explored. Recent advances in microwave-assisted synthesis and electrochemical synthesis are presented in this review. In recent years, post-synthetic approaches have been shown to be powerful tools to synthesize MOFs with modified functionality, which cannot be attained via de novo synthesis. In this review, some current accomplishments of post-synthetic modification (PSM) based on covalent transformations and coordinative interactions as well as post-synthetic exchange (PSE) in robust MOFs are provided. PMID:27877831

  14. Progress in organic molecular single crystal FET electronics

    NASA Astrophysics Data System (ADS)

    Butko, Vladimir; Chi, Xiaoliu; Ramirez, Arthur

    2004-03-01

    Semiconducting organic materials have received increased attention because they promise bulk processing of flexible, large-area electronic devices. Field Effect Transistors (FETs) provide a powerful method of investigating two-dimensional properties of these materials. We report on fabrication and characterization of FETs on organic molecular single-crystals of pentacene and tetracene [1,2]. The FETs exhibit hole conductivity with room temperature record effective mobility, up to 2 -3 cm^2/Vs and on/off ratios up to 2*10^7. We were able to suppress an activation energy of pentacene down to ˜ 30 mK by applying gate voltage of 45 V. 1. V.Y. Butko, X. Chi, D. V. Lang and A. P. Ramirez, Applied Physics Letters, v.83, #23, pp. 4773-4775, December 8, 2003 2. V.Y. Butko, X. Chi, A. P. Ramirez , Solid State Communications, v. 128/11, pp. 431, 2003

  15. Recent progress in the synthesis of metal-organic frameworks

    NASA Astrophysics Data System (ADS)

    Sun, Yujia; Zhou, Hong-Cai

    2015-10-01

    Metal-organic frameworks (MOFs) have attracted considerable attention for various applications due to their tunable structure, porosity and functionality. In general, MOFs have been synthesized from isolated metal ions and organic linkers under hydrothermal or solvothermal conditions via one-spot reactions. The emerging precursor approach and kinetically tuned dimensional augmentation strategy add more diversity to this field. In addition, to speed up the crystallization process and create uniform crystals with reduced size, many alternative synthesis routes have been explored. Recent advances in microwave-assisted synthesis and electrochemical synthesis are presented in this review. In recent years, post-synthetic approaches have been shown to be powerful tools to synthesize MOFs with modified functionality, which cannot be attained via de novo synthesis. In this review, some current accomplishments of post-synthetic modification (PSM) based on covalent transformations and coordinative interactions as well as post-synthetic exchange (PSE) in robust MOFs are provided.

  16. Recent progress in the synthesis of metal–organic frameworks

    SciTech Connect

    Sun, Yujia; Zhou, Hong -Cai

    2015-09-25

    Metal–organic frameworks (MOFs) have attracted considerable attention for various applications due to their tunable structure, porosity and functionality. In general, MOFs have been synthesized from isolated metal ions and organic linkers under hydrothermal or solvothermal conditions via one-spot reactions. The emerging precursor approach and kinetically tuned dimensional augmentation strategy add more diversity to this field. In addition, to speed up the crystallization process and create uniform crystals with reduced size, many alternative synthesis routes have been explored. Recent advances in microwave-assisted synthesis and electrochemical synthesis are presented in this review. In recent years, post-synthetic approaches have been shown to be powerful tools to synthesize MOFs with modified functionality, which cannot be attained via de novo synthesis. In this study, some current accomplishments of post-synthetic modification (PSM) based on covalent transformations and coordinative interactions as well as post-synthetic exchange (PSE) in robust MOFs are provided.

  17. Recent progress in the synthesis of metal–organic frameworks

    DOE PAGES

    Sun, Yujia; Zhou, Hong -Cai

    2015-09-25

    Metal–organic frameworks (MOFs) have attracted considerable attention for various applications due to their tunable structure, porosity and functionality. In general, MOFs have been synthesized from isolated metal ions and organic linkers under hydrothermal or solvothermal conditions via one-spot reactions. The emerging precursor approach and kinetically tuned dimensional augmentation strategy add more diversity to this field. In addition, to speed up the crystallization process and create uniform crystals with reduced size, many alternative synthesis routes have been explored. Recent advances in microwave-assisted synthesis and electrochemical synthesis are presented in this review. In recent years, post-synthetic approaches have been shown to bemore » powerful tools to synthesize MOFs with modified functionality, which cannot be attained via de novo synthesis. In this study, some current accomplishments of post-synthetic modification (PSM) based on covalent transformations and coordinative interactions as well as post-synthetic exchange (PSE) in robust MOFs are provided.« less

  18. Recent progress in the synthesis of metal-organic frameworks.

    PubMed

    Sun, Yujia; Zhou, Hong-Cai

    2015-10-01

    Metal-organic frameworks (MOFs) have attracted considerable attention for various applications due to their tunable structure, porosity and functionality. In general, MOFs have been synthesized from isolated metal ions and organic linkers under hydrothermal or solvothermal conditions via one-spot reactions. The emerging precursor approach and kinetically tuned dimensional augmentation strategy add more diversity to this field. In addition, to speed up the crystallization process and create uniform crystals with reduced size, many alternative synthesis routes have been explored. Recent advances in microwave-assisted synthesis and electrochemical synthesis are presented in this review. In recent years, post-synthetic approaches have been shown to be powerful tools to synthesize MOFs with modified functionality, which cannot be attained via de novo synthesis. In this review, some current accomplishments of post-synthetic modification (PSM) based on covalent transformations and coordinative interactions as well as post-synthetic exchange (PSE) in robust MOFs are provided.

  19. [World Population Day: progress in organization in the Sahel].

    PubMed

    1993-08-01

    Soil degradation, energy consumption, women and education, age structure of the population, and people's needs were some of the themes for the 1993 celebration of World Population Day (July 11). United Nations Population Fund (UNFPA) and national authorities of UN members organized it. World Population Day is an occasion to bring attention to population issues so the public and decision makers can achieve sustainable development. This year, the event examined support of an agreed effort at a global level to find an equilibrium between population, development, and the environment. World Population Day was celebrated half-way between the Rio Conference on the Environment (June 1992) and the World Population Conference in September 1994 in Cairo. In the Sahel region, the organization of earlier World Population Days had, without doubt, favorable effects since, this year, World Population Day was celebrated over several days, sometimes even for an entire week, e.g., Mali and Chad. Some speeches were presented, audiovisual spots were broadcast, articles were published in the press, and various other organized activities occurred, which allowed World Population Day to stress the importance of population issues. UNFPA's executive director believes it is possible to find some sustainable solutions to the problems of the environment and poverty if we rise to the occasion to resolve population issues.

  20. [Progress of organometallic complexes and their application to organic electroluminescent materials].

    PubMed

    Zhou, Rui; An, Zhong-Wei; Chai, Sheng-Yong

    2004-08-01

    Organic electroluminescent (EL) material is one of most prospective display materials in flat panel display. Organometallic complexes, which have five or six member ring structures, with high stability, high melting point and high fluorescence quantum efficiency, are widely applied in organic EL devices. The recent progress in organometallic complexes is summarized in terms of the electroluminescence of ligands and metal atoms.

  1. The Learning Organization: Tracking Progress in a Developing Country--A Comparative Analysis Using the DLOQ

    ERIC Educational Resources Information Center

    Jamali, Dima; Sidani, Yusuf; Zouein, Charbel

    2009-01-01

    Purpose: The purpose of this paper is to survey the various measurement instruments of the learning organization on offer, leading to the adoption of a tool that was considered most suitable for gauging progress towards the learning organization in two sectors of the Lebanese economy, namely banking and information technology (IT).…

  2. Organization of the R chromosome region in maize. [Progress report

    SciTech Connect

    Kermicle, J.

    1992-03-01

    The maize R gene is said to show more phenotypic variation than any other locus in higher plants. The locus is organized on a modular basis. Individual units -- termed ``genic elements`` since they function as independent genes -- differ by regulating the presence, intensity and timing of anthocyanin pigmentation in different plant parts. A given allele may comprise only one genic element or, more commonly, an allele comprises a complex of elements, organized as a small gene family. Different numbers and combinations of even a few genic elements gives a large number of possible complexes. Following molecular cloning of R we concentrated effort initially on a genic element that confers strong pigmentation only to the kernel. The functional limits of this gene (R-sc:124) had been defined genetically by extensive mutagenesis with the transposable element Dissociation. Subsequently, a set of contiguous probes were prepared from a genomic clone of R-sc:124. This set of probes distinguishes among various R-genic elements, providing physical evidence on gene complexes whose overall organization had been determined genetically. Some surprises were in store, as detailed below. These same tools made it possible to analyze the effect of position of Ds insertion within R-sc:124 on spotting phenotype, germinal reversion rate and frequency of Ds excision. Furthermore, we are now able to address in much more detail some of the unique phenomena of R action, such as a difference in kernel phenotype when certain alleles are transmitted by ovules relative to sperm. The last category of objectives is discussed in the section entitled ``updated research plan.``

  3. Reaction of organic material to progressive geologic heating

    SciTech Connect

    Creaney, S.

    1985-02-01

    The generation of oil is a process that begins to occur at some point during the burial history of a source rock. This onset of maturation is dictated largely by temperature and residence time. However, the nature of the source rock itself also influences the hydrocarbon product being expelled from the source rock. The vast majority of the world's oil can be ascribed to source rocks of the following types. (1) Marine mudrocks deposited in anoxic conditions and dominated by phytoplankton organisms; this type of source rock can have a carbonate or clay inorganic matrix and total organic carbon values from 1 to 30% (commonly 4 to 10% when immature). Examples of this classical oil source rock would be the source rocks of western Canada, the Middle East, and the North Sea. (2) Specific coal facies such as torbanites and channel coals, which contain a mixture of hydrogen-rich plant detritus (e.g., spores, pollen, cuticle, resin, and algae); deposition was probably in open-water areas of an overall coal-swamp environment. Examples of hydrocarbons from this type of source include the Gippsland basin, Canadian Beaufort Sea, and Southeast Asia. (3) Lacustrine organic-rich deposits, rich in freshwater algae, which ultimately result in high-wax crude oils. Examples are relatively rare, but include major source rocks in the Uinta basin and China. The effect of increasing maturity on marine mudrocks of the Devonian Duvernay Formation of Alberta illustrates oil generation from this type of source rock. The data base in this unit consists of 40 conventional cores, ranging from immature to completely overmature, and 80 oils from separate accumulations sourced from the Duvernay. An illustration of oil generation in a coaly source rock is provided by a single core from the Lower Cretaceous of the Beaufort-Mackenzie basin plus many of the oils and condensates reservoired in that area.

  4. Recent progress of high performance polymer OLED and OPV materials for organic printed electronics

    NASA Astrophysics Data System (ADS)

    Sekine, Chizu; Tsubata, Yoshiaki; Yamada, Takeshi; Kitano, Makoto; Doi, Shuji

    2014-06-01

    The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported.

  5. Recent progress of high performance polymer OLED and OPV materials for organic printed electronics

    PubMed Central

    Sekine, Chizu; Tsubata, Yoshiaki; Yamada, Takeshi; Kitano, Makoto; Doi, Shuji

    2014-01-01

    The development of organic printed electronics has been expanding to a variety of applications and is expected to bring innovations to our future life. Along with this trend, high performance organic materials with cost-efficient fabrication processes and specific features such as thin, light weight, bendable, and low power consumption are required. A variety of organic materials have been investigated in the development of this field. The basic guidelines for material design and the recent progress of polymer-based organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs) are reported. PMID:27877671

  6. Perceived Progress, Risks of Information Sharing and Interoperability between Military Organizations and Federal Agencies

    ERIC Educational Resources Information Center

    Aburto, Rafael

    2014-01-01

    This qualitative study examined efforts by the military organizations and federal agencies to improve information sharing, interoperability, and systems integration in all business practices. More specifically, a survey instrument with six open-ended and eight demographic questions was used to measure the perceived progress, issues, challenges of…

  7. Graphitization of Organic Material in a Progressively Metamorphosed Precambrian Iron Formation.

    PubMed

    French, B M

    1964-11-13

    Organic matter in the sedimentary Biwabik iron formation in northern Minnesota shows a progressive increase in crystallinity where the formation is metamorphosed by the intrusive Duluth gabbro complex. X-ray diffraction of acid-insoluble residues shows that there is a complete range in crystallinity, from amorphous material in the unmetamorphosed sediments to completely crystalline graphite adjacent to the gabbro.

  8. Organic geochemistry: Effects of organic components of shales on adsorption: Progress report

    SciTech Connect

    Ho, P.C.

    1988-11-01

    The Sedimentary Rock Program at the Oak Ridge National Laboratory is investigating shale to determine its potential suitability as a host rock for the disposal of high-level radioactive wastes (HLW). The selected shales are Upper Dowelltown, Pierre, Green River Formation, and two Conasauga (Nolichucky and Pumpkin Valley) Shales, which represent mineralogical and compositional extremes of shales in the United States. According to mineralogical studies, the first three shales contain 5 to 13 wt % of organic matter, and the two Conasauga Shales only contain trace amounts (2 wt %) of organic matter. Soxhlet extraction with chloroform and a mixture of chloroform and methanol can remove 0.07 to 5.9 wt % of the total organic matter from these shales. Preliminary analysis if these organic extracts reveals the existence of organic carboxylic acids and hydrocarbons in these samples. Adsorption of elements such as Cs(I), Sr(II) and Tc(VII) on the organic-extracted Upper Dowelltown, Pierre, green River Formation and Pumpkin Valley Shales in synthetic groundwaters (simulating groundwaters in the Conasauga Shales) and in 0.03-M NaHCO/sub 3/ solution indicates interaction between each of the three elements and the organic-extractable bitumen. 28 refs., 8 figs., 10 tabs.

  9. Organic Tanks Safety Program: Advanced organic analysis FY 1996 progress report

    SciTech Connect

    1996-09-01

    Major focus during the first part of FY96 was to evaluate using organic functional group concentrations to screen for energetics. Fourier transform infrared and Raman spectroscopy would be useful screening tools for determining C-H and COO- organic content in tank wastes analyzed in a hot cell. These techniques would be used for identifying tanks of potential safety concern that may require further analysis. Samples from Tanks 241-C-106 and -C-204 were analyzed; the major organic in C-106 was B2EHPA and in C-204 was TBP. Analyses of simulated wastes were also performed for the Waste Aging Studies Task; organics formed as a result of degradation were identified, and the original starting components were monitored quantitatively. Sample analysis is not routine and required considerable methods adaptation and optimization. Several techniques have been evaluated for directly analyzing chelator and chelator fragments in tank wastes: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and liquid chromatography with ultraviolet detection using Cu complexation. Although not directly funded by the Tanks Safety Program, the success of these techniques have implications for both the Flammable Gas and Organic Tanks Safety Programs.

  10. Recent progress of dopant-free organic hole-transporting materials in perovskite solar cells

    NASA Astrophysics Data System (ADS)

    Dongxue, Liu; Liu, Yongsheng

    2017-01-01

    Organic–inorganic hybrid perovskite solar cells have undergone especially intense research and transformation over the past seven years due to their enormous progress in conversion efficiencies. In this perspective, we review the latest developments of conventional perovskite solar cells with a main focus on dopant-free organic hole transporting materials (HTMs). Regarding the rapid progress of perovskite solar cells, stability of devices using dopant-free HTMs are also discussed to help readers understand the challenges and opportunities in high performance and stable perovskite solar cells. Project supported by the Scientific Research Starting Foundation for Overseas Introduced Talents of College of Chemistry, Nankai University.

  11. Waste Tank Organic Safety Program: Analytical methods development. Progress report, FY 1994

    SciTech Connect

    Campbell, J.A.; Clauss, S.A.; Grant, K.E.

    1994-09-01

    The objectives of this task are to develop and document extraction and analysis methods for organics in waste tanks, and to extend these methods to the analysis of actual core samples to support the Waste Tank organic Safety Program. This report documents progress at Pacific Northwest Laboratory (a) during FY 1994 on methods development, the analysis of waste from Tank 241-C-103 (Tank C-103) and T-111, and the transfer of documented, developed analytical methods to personnel in the Analytical Chemistry Laboratory (ACL) and 222-S laboratory. This report is intended as an annual report, not a completed work.

  12. Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

    PubMed Central

    Nagpal, Harsh; Hori, Tetsuya; Furukawa, Ayako; Sugase, Kenji; Osakabe, Akihisa; Kurumizaka, Hitoshi; Fukagawa, Tatsuo

    2015-01-01

    The kinetochore is a crucial structure for faithful chromosome segregation during mitosis and is formed in the centromeric region of each chromosome. The 16-subunit protein complex known as the constitutive centromere-associated network (CCAN) forms the foundation for kinetochore assembly on the centromeric chromatin. Although the CCAN can be divided into several subcomplexes, it remains unclear how CCAN proteins are organized to form the functional kinetochore. In particular, this organization may vary as the cell cycle progresses. To address this, we analyzed the relationship of centromeric protein (CENP)-C with the CENP-H complex during progression of the cell cycle. We find that the middle portion of chicken CENP-C (CENP-C166–324) is sufficient for centromere localization during interphase, potentially through association with the CENP-L-N complex. The C-terminus of CENP-C (CENP-C601–864) is essential for centromere localization during mitosis, through binding to CENP-A nucleosomes, independent of the CENP-H complex. On the basis of these results, we propose that CCAN organization changes dynamically during progression of the cell cycle. PMID:26354420

  13. Tank Waste Remediation System Tank Waste Analysis Plan. FY 1995

    SciTech Connect

    Haller, C.S.; Dove, T.H.

    1994-11-01

    This documents lays the groundwork for preparing the implementing the TWRS tank waste analysis planning and reporting for Fiscal Year 1995. This Tank Waste Characterization Plan meets the requirements specified in the Hanford Federal Facility Agreement and Consent Order, better known as the Tri-Party Agreement.

  14. The AMTEX Partnership. Third quarterly report, FY 1995

    SciTech Connect

    Lemon, D.K.; Quisenberry, R.K.

    1995-06-01

    Key activities for the quarter were the initiation of tactical work on the OPCon Project, development of a draft of the AMTEX Policies and Procedures document, and a meeting of the Industry Technical Advisory Committee. A significant milestone was reached when a memorandum of understanding was signed between the DOE and The Department of Commerce. The agreement signified the official participation of the National Institute of Standards and Technology on the Demand Activated Manufacturing Architecture (DAMA) project in AMTEX. Project accomplishments are given for: computer-aided manufacturing, cotton biotechnology, DAMA, electronic embedded fingerprints, rapid cutting, sensors for agile manufacturing, and textile resource conservation.

  15. NASA University Program Management Information System: FY 1995

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The University Program Report, Fiscal Year 1995, provides current information and related statistics for grants/contracts/cooperative agreements active during the report period. NASA field centers and certain Headquarters program offices provide funds for those R&D activities in universities which contribute to the mission needs of that particular NASA element. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA's University Program.

  16. OSU Reactor Sharing Program FY 1995 annual report

    SciTech Connect

    Higginbotham, J.F.

    1996-10-01

    This is the annual report of the activities supported under the Oregon State University Reactor Sharing Program, award number DE-FG06-NE38137. The beginning date for the award was September, 30, 1995 and the end date was September 29, 1996. Work conducted under this award is internally administered at the Radiation Center through a project tasking system. This allows for excellent quality control for the work which is performed from the point of initial contact, through the reactor application, project report generation and financial accounting. For the current fiscal year, FY95, the total cost of the reactor sharing program, including Radiation Center contributions, was $66,323.20 of which $40,000.00 was supplied by the DOE Reactor Sharing Program. The details of individual project costs is given in Table 1. The work performed for the individual projects are described in the brief work descriptions given in Table 2.

  17. Oak Ridge National Laboratory Institutional Plan, FY 1995--FY 2000

    SciTech Connect

    Not Available

    1994-11-01

    This report discusses the institutional plan for Oak Ridge National Laboratory for the next five years (1995-2000). Included in this report are the: laboratory director`s statement; laboratory mission, vision, and core competencies; laboratory plan; major laboratory initiatives; scientific and technical programs; critical success factors; summaries of other plans; and resource projections.

  18. FY 1995 Cohort Default Rates for Originating Lenders/Holders.

    ERIC Educational Resources Information Center

    Office of Postsecondary Education (ED), Washington, DC.

    This report provides data on fiscal year 1995 cohort default rates for lending institutions and loan holders with 30 or more borrowers in repayment, calculated from data reported to the National Student Loan Data System by guaranty agencies. Types of loans covered include subsidized Federal Stafford, unsubsidized Federal Stafford, Federal…

  19. Technical Support Section annual work plan for FY 1995

    SciTech Connect

    Adkisson, B.P.; Hess, R.A.; Kunselman, C.W.; Millet, A.J.; Smelcer, D.R.

    1994-10-01

    The Technical Support Section (TSS) of the Instrumentation and Controls (I and C) Division of Oak Ridge National Laboratory (ORNL) provides technical services such as fabrication, modification, installation, calibration, operation, repair, and preventive maintenance of instruments and other related equipment. Work performed by TSS is in support of basic and applied research and development (R and D), engineering, and instrument and computer systems managed by ORNL. Because the activities and priorities of TSS must be adapted to the technical support needs of ORNL, the TSS Annual Work Plan is derived from and driven directly by current trends in the budgets and activities of each ORNL division for which TSS provides support. Trends that will affect TSS planning during this period are reductions in the staffing levels of some R and D programs because of attrition or budget cuts and the establishment of new facilities or environmental safety and health programs. The ``Long-Range Work Plan`` is based on estimates of impact of the long-range priorities and directions of the Laboratory. Identifiable proposed new facilities and programs provide additional basis for long-range planning. After identifying long-range initiatives, TSS planning includes future training requirements, reevaluation of qualifications for new-hires, and identification of essential test equipment needed in new work.

  20. Program status 4. quarter -- FY 1995: ITER and technology

    SciTech Connect

    1995-10-24

    A scoping level analysis of heat exhaust for the DEMO divertor strawman design was performed. It was concluded that to reduce the surface heat flux to the divertor, a combination of impurities radiation, compression, and increase in SOL electron density will have to be used. GA completed the preparation on the description of the helium-cooled, lithium breeder and V-alloy/ferritic steel DEMO blanket design focusing on addressing the issues of materials compatibility and reliability of high pressure gas system. Using ferritic steel, a helium Li-breeder design can handle neutron wall loading in the range of 6 to 8 MW/M{sup 2}. With advanced material like V-alloy, neutron wall loading in the range of 9 to 11 MW/m{sup 2} can be handled by similar design. The design of all components for a combline antenna for JFT-2M has been completed. Completion of the fabrication is scheduled for 11/95. The 4in x 4in 110 GHz window was fabricated and delivered to CPI (Varian) for testing. The second DiMES sample with Be/W striped coatings was exposed to four DIII-D plasma shots. Deuterium areal density measurements by W. Wampler of SNL showed the results from Be/W and Mo/V coated DiMES samples. High uptake of about 2x10{sup 17} atoms/cm{sup 2} was recorded for V. Be and C were lower by a factor of two, and Mo and W were lowest by about a factor of ten. An ITER magnetic coil has been fabricated and shipped to Brookhaven awaiting time for radiation testing. High-Nicalon and Super-Nicalon SiC fibers were received from PNL. Fabrication of different composite samples with different coatings is proceeding.

  1. Research in the chemical sciences. Summaries of FY 1995

    SciTech Connect

    1995-09-01

    This summary book is published annually to provide information on research supported by the Department of Energy`s Division of Chemical Sciences, which is one of four Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries provide the scientific and technical public, as well as the legislative and executive branches of the Government, information, either generally or in some depth, about the Chemical Sciences program. Scientists interested in proposing research for support will find the publication useful for gauging the scope of the present basic research program and it`s relationship to their interests. Proposals that expand this scope may also be considered or directed to more appropriate offices. The primary goal of the research summarized here is to add significantly to the knowledge base in which existing and future efficient and safe energy technologies can evolve. As a result, scientific excellence is a major criterion applied in the selection of research supported by the Division of Chemical Sciences, but another important consideration is emphasis on science that is advancing in ways that will produce new information related to energy.

  2. Lawrence Berkeley Laboratory Institutional Plan FY 1995--2000

    SciTech Connect

    1994-12-01

    This report presents the details of the mission and strategic plan for Lawrence Berkeley Laboratory during the fiscal years of 1995--2000. It presents summaries of current programs and potential changes; critical success factors such as human resources; management practices; budgetary allowances; and technical and administrative initiatives.

  3. Information Resources Management Long Range Plan, FY 1995-1999

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Table of Contents: Introduction; Agency 5-Year IRM Investment Projections; Major IRM Program Accomplishments for FY 1993; Information Collection Budget; Summary of Computer Security Plans; Appendix: Acronym List.

  4. Congressional Submission RDT&E Descriptive Summaries, FY 1995

    DTIC Science & Technology

    1994-02-01

    C 00V-4.AWQ04) 0 4.4 .1 X 43.)40)0 4) V4: CCM 4 0 05400 0, 4 .- l 0 1r 430)09 43 0 4) 000 > 1 0 r: 4 A0) 0 014. C1 0 14.4.) Ag .0 -t4 4 j V -4 4-)0...0 r-4 ., 44 00 Ag H - 0> 140 $24 uŘ 0% V.C0 4J1 r4 *.4 0 020..C4 2).4. : w R- 02020% 4 4 12 4 H 0. 4) 4)- o I )oo (1 0 4)0 $ cC: 410 UC 0 0 C 0jM1...i $4 inn U) 04) 41C-4 in 04) -A4 0441 :3 0~ M -441)0Vd1 0 v0 v.4 041r M4 ~ 4id (L X : A U -4~ 04) E-4 > 0-4-9w 4) 0 94nt a) 04 At W. 4)144 0J-9

  5. Missouri Coordinating Board for Higher Education: FY 1995 Annual Report.

    ERIC Educational Resources Information Center

    Missouri State Coordinating Board for Higher Education, Jefferson City.

    The annual report on the state of Missouri higher education provides information on system finance, operations, and planning at the state level. First, highlights are identified in the areas of: enhancements, a new state technical college, Missouri Student Loan Program innovations, performance funding, and a new blueprint for higher education. An…

  6. FY 1995 research highlights: PNL accomplishments in OER programs

    SciTech Connect

    1995-10-01

    Pacific Northwest Laboratory (PNL) conducts fundamental and applied research in support of the US Department of Energy`s (DOE) core missions in science and technology, environmental quality, energy resources, and national security. Much of this research is funded by the program offices of DOE`s Office of Energy Research (DOE-ER), primarily the Office of Basic Energy Sciences (BES) and the Office of Health and Environmental Research (OHER), and by PNL`s Laboratory Directed Research and Development (LDRD) Program. This document is a collection of research highlights that describe PNL`s accomplishments in DOE-ER funded programs during Fiscal Year 1995. Included are accomplishments in research funded by OHER`s Analytical Technologies, Environmental Research, Health Effects, General Life Sciences, and Carbon Dioxide Research programs; BES`s Materials Science, Chemical Sciences, Engineering and Geoscience, and Applied Mathematical Sciences programs; and PNL`s LDRD Program. Summaries are given for 70 projects.

  7. Laboratory Directed Research and Development Program, FY 1995

    SciTech Connect

    1995-12-31

    This program provides the resources for Berkeley Lab scientists to make rapid and significant contributions to critical nation science and technology problems: accelerators and fusion, chemical sciences, earth sciences, energy and environment, engineering, life sciences, materials, nuclear science, physics, and structural biology (hyperthermophilic microorganisms).

  8. Pacific Northwest Laboratory Institutional Plan FY 1995-2000

    SciTech Connect

    Not Available

    1994-12-01

    This report serves as a document to describe the role PNL is positioned to take in the Department of Energy`s plans for its national centers in the period 1995-2000. It highlights the strengths of the facilities and personnel present at the laboratory, touches on the accomplishments and projects they have contributed to, and the direction being taken to prepare for the demands to be placed on DOE facilities in the near and far term. It consists of sections titled: director`s statement; laboratory mission and core competencies; laboratory strategic plan; laboratory initiatives; core business areas; critical success factors.

  9. Analog site for fractured rock characterization. Annual report FY 1995

    SciTech Connect

    Long, J.C.S.; Loughty, C.; Faybishenko, B.

    1995-10-01

    This report describes the accomplishments of the Analog Site for Fracture Rock Characterization Project during fiscal year 1995. This project is designed to address the problem of characterizing contaminated fractured rock. In order to locate contaminant plumes, develop monitoring schemes, and predict future fate and transport, the project will address the following questions: What parts of the system control flow-geometry of a fracture network? What physical processes control flow and transport? What are the limits on measurements to determine the above? What instrumentation should be used? How should it be designed and implemented? How can field tests be designed to provide information for predicting behavior? What numerical models are good predictors of the behavior of the system? The answers to these question can be used to help plan drilling programs that are likely to intersect plumes and provide effective monitoring of plume movement. The work is done at an {open_quotes}analogue{close_quotes} site, i.e., a site that is not contaminated, but has similar geology to sites that are contaminated, in order to develop tools and techniques without the financial, time and legal burdens of a contaminated site. The idea is to develop conceptual models and investigations tools and methodology that will apply to the contaminated sites in the same geologic regimes. The Box Canyon site, chosen for most of this work represents a unique opportunity because the Canyon walls allow us to see a vertical plane through the rock. The work represents a collaboration between the Lawrence Berkeley National Laboratory (LBL), Stanford University (Stanford), Idaho National Engineering Laboratory (INEL) and Parsons Environmental Engineering (Parsons). LBL and Stanford bring extensive experience in research in fractured rock systems. INEL and Parsons bring significant experience with the contamination problem at INEL.

  10. United States Department of Energy Budget Highlights FY 1995

    SciTech Connect

    O`Leary, H.R.

    1994-02-01

    The Department of Energy is entrusted to contribute to the welfare of the Nation by providing the scientific and educational foundation or the technology, policy, and institutional leadership necessary to achieve efficiency in energy use, diversity in energy sources, and access to technical information required for a more productive and competitive economy, improved environmental quality, and a secure national defense.

  11. Oak Ridge National Laboratory institutional plan, FY 1990--FY 1995

    SciTech Connect

    Not Available

    1989-11-01

    The Oak Ridge National Laboratory is one of DOE's major multiprogram energy laboratories. ORNL's program missions are (1) to conduct applied research and engineering development in support of DOE's programs in fusion, fission, fossil, renewables (biomass), and other energy technologies, and in the more efficient conversion and use of energy (conservation) and (2) to perform basic scientific research in selected areas of the physical and life sciences. These missions are to be carried out in compliance with environmental, safety, and health regulations. Transfer of science and technology is an integral component of our missions. A complementary mission is to apply the Laboratory's resources to other nationally important tasks when such work is synergistic with the program missions. Some of the issues addressed include education, international competitiveness, hazardous waste research and development, and selected defense technologies. In addition to the R D missions, ORNL performs important service roles for DOE; these roles include designing, building, and operating user facilities for the benefit of university and industrial researchers and supplying radioactive and stable isotopes that are not available from private industry. Scientific and technical efforts in support of the Laboratory's missions cover a spectrum of activities. In fusion, the emphasis is on advanced studies of toroidal confinement, plasma heating, fueling systems, superconducting magnets, first-wall and blanket materials, and applied plasma physics. 69 figs., 49 tabs.

  12. Environmental Sciences Division: Summaries of research in FY 1995

    SciTech Connect

    1996-09-01

    This report focuses on research in global change, as well as environmental remediation. Global change research investigates the following: distribution and balance of radiative heat energy; identification of the sources and sinks of greenhouse gases; and prediction of changes in the climate and concomitant ecological effects. Environmental remediation develops the basic understanding needed to remediate soils, sediments, and ground water that have undergone radioactive and chemical contamination.

  13. Summary report of FY 1995 Raman spectroscopy technology development

    SciTech Connect

    Douglas, J.G.

    1995-11-01

    US DOE is sponsoring development of remote, fiber-optic Raman spectroscopy for rapid chemical characterization of Hanford high-level radioactive tank waste. Deployment targets for this technology are analytical hot cells and, via the Light-Duty Utility Arm and cone penetrometer, the waste tanks themselves. Perceived benefits of fiber-optic Raman spectroscopy are (1) rapid generation of tank-waste safety-related data, (2) reduced personnel exposure to highly radioactive waste, (3) reduced tank-waste sampling and analysis costs, and (4) reduced radioactive analytical waste. This document presents the results from the investigation of two dispersive, transmission-grating Raman systems and four fiber-optic Raman probe designs with non-radioactive tank waste simulants. One Raman system used a 532-nm, 400 mW, solid-state laser; the other used a 785-nm, 500 mW, solid-state diode laser. We found (1) the transmission-grating systems had better wavelength stability than previously tried Czerny-Turner-Based systems and (2) the 785-nm system`s specie detection limits in the spectral fingerprint regiion were at least as good as those for the 532-nm system. Based on these results, and the fact that some tank wastes luminesce with 514.5nm excitation, we selected the 785-nm system for hot-cell use. Of the four probes tested, three had a ``six-around-on`` fiber probe design; the fourth probe was a one-fiber-in-one-fiber-out, diffuse-relectance design. Comparison of the four probes` signal-to-noise rations, rations, transmission/collection efficiencies, and probe-silica Raman backgrounds showed that the best probe for use with Hanford-Site tank waste should (1) be filtered as close to the probe tip as possible to reduce the probe-silica Raman background and (2) have multiple collection fibers. The responses of all the probes tested showed a strong dependence on probe-sample distance, and the presence of a probe window appeared to increase the probe`s silica Raman background.

  14. Progress Towards Identifying and Quantifying the Organic Ice Nucleating Particles in Soils and Aerosols

    NASA Astrophysics Data System (ADS)

    Hill, T. C. J.; DeMott, P. J.; Fröhlich-Nowoisky, J.; Tobo, Y.; Suski, K. J.; Levin, E. J.; Kreidenweis, S. M.; Franc, G. D.

    2014-12-01

    Soil and plant surfaces emit ice nucleating particles (INP) to the atmosphere, especially when disturbed by wind, harvesting, rain or fire. Organic (biogenic) INP are abundant in most soils and dominate the population that nucleate >-15°C. For example, the sandy topsoil of sagebrush shrubland, a widespread ecotype prone to wind erosion after fire, contains ~106 organic INP g-1 at -6°C. The relevance of organic INP may also extend to colder temperatures than previously thought: Particles of soil organic matter (SOM) have been shown to be more important than mineral particles for the ice nucleating ability of agricultural soil dusts to -34°C. While the abundance of ice nucleation active (INA) bacteria on plants has been established, the identity of the organic INP in and emitted by soils remains a 40-year-old mystery. The need to understand their production and release is highlighted by recent findings that INA bacteria (measured with qPCR) account for few, if any, of the warm-temperature organic INP that predominate in boundary layer aerosols and snow; organic INP lofted with soil dusts seem a likely source. The complexity of SOM hinders its investigation. It contains decomposing plant materials, a diverse microbial and microfaunal community, humus, and inert organic matter. All are biochemically complex and all may contain ice nucleating constituents, either by design or by chance. Indeed the smoothness of the INP temperature spectra of soils is indicative of numerous, overlapping distributions of INP. We report recent progress in identifying and quantifying the organic INP in soils and boundary layer aerosols representative of West Central U.S. ecosystems, and how their characteristics may affect their dispersal. Chemical, enzymatic and DNA-based tests were used to assess contributions of INP from plant tissues, INA bacteria, INA fungi, organic crystals, monolayers of aliphatic alcohols, carbohydrates, and humic substances, while heat- and peroxide-based tests

  15. Dissolved organic matter and lake metabolism. Technical progress report, 1 July 1979-30 June 1980

    SciTech Connect

    Wetzel, R.G.

    1980-01-01

    Progress in research to evaluate the impact of utilization of fossil fuels on surface water is reported. Analyses of regulatory mechanisms of growth and rates of carbon cycling center on evaluation of quantitative control interactions among the microflora of the pelagial zones of several lakes of progressively greater eutrophy, littoral photosynthetic producer-decomposer complex, and allochthonous inorganic-organic influxes and their biotic processing. The underlying thesis is that quantification of the dynamic carbon fluxes among these components and their rate control mechanisms by physical and chemical factors are fundamental to elucidation of the rate functions of lake eutrophication. A major portion of the research has been directed towards the fate and nutrient mechanisms regulating qualitative and quantitative utilization and losses of organic carbon synthesized within lakes and their drainage basins. It has become increasingly apparent that the wetland and littoral flora, and attendant epiphytic and benthic microflora, have major regulatory controls on biogeochemical cycling of whole lake systems. A major effort on factors regulating the metabolism of littoral macrophytes and attached algae has been coupled to integrated studies on their decomposition and the fate of detrital dissolved and particulate organic matter. These organic products are being coupled to influences on enzymatic activity and inorganic nutrient cycling.

  16. [Deposition and burial of organic carbon in coastal salt marsh: research progress].

    PubMed

    Cao, Lei; Song, Jin-Ming; Li, Xue-Gang; Yuan, Hua-Mao; Li, Ning; Duan, Li-Qin

    2013-07-01

    Coastal salt marsh has higher potential of carbon sequestration, playing an important role in mitigating global warming, while coastal saline soil is the largest organic carbon pool in the coastal salt marsh carbon budget. To study the carbon deposition and burial in this soil is of significance for clearly understanding the carbon budget of coastal salt marsh. This paper summarized the research progress on the deposition and burial of organic carbon in coastal salt marsh from the aspects of the sources of coastal salt marsh soil organic carbon, soil organic carbon storage and deposition rate, burial mechanisms of soil organic carbon, and the relationships between the carbon sequestration in coastal salt marsh and the global climate change. Some suggestions for the future related researches were put forward: 1) to further study the underlying factors that control the variability of carbon storage in coastal salt marsh, 2) to standardize the methods for measuring the carbon storage and the deposition and burial rates of organic carbon in coastal salt marsh, 3) to quantify the lateral exchange of carbon flux between coastal salt marsh and adjacent ecosystems under the effects of tide, and 4) to approach whether the effects of global warming and the increased productivity could compensate for the increase of the organic carbon decomposition rate resulted from sediment respiration. To make clear the driving factors determining the variability of carbon sequestration rate and how the organic carbon storage is affected by climate change and anthropogenic activities would be helpful to improve the carbon sequestration capacity of coastal salt marshes in China.

  17. Alchemy in the underworld - recent progress and future potential of organic geochemistry applied to speleothems.

    NASA Astrophysics Data System (ADS)

    Blyth, Alison

    2016-04-01

    Speleothems are well used archives for chemical records of terrestrial environmental change, and the integration of records from a range of isotopic, inorganic, and organic geochemical techniques offers significant power in reconstructing both changes in past climates and identifying the resultant response in the overlying terrestrial ecosystems. The use of organic geochemistry in this field offers the opportunity to recover new records of vegetation change (via biomarkers and compound specific isotopes), temperature change (via analysis of glycerol dialkyl glycerol tetraethers, a compound group derived from microbes and varying in structure in response to temperature and pH), and changes in soil microbial behaviour (via combined carbon isotope analysis). However, to date the use of organic geochemical techniques has been relatively limited, due to issues relating to sample size, concerns about contamination, and unanswered questions about the origins of the preserved organic matter and rates of transport. Here I will briefly review recent progress in the field, and present a framework for the future research needed to establish organic geochemical analysis in speleothems as a robust palaeo-proxy approach.

  18. 25th anniversary article: progress in chemistry and applications of functional indigos for organic electronics.

    PubMed

    Głowacki, Eric Daniel; Voss, Gundula; Sariciftci, Niyazi Serdar

    2013-12-17

    Indigo and its derivatives are dyes and pigments with a long and distinguished history in organic chemistry. Recently, applications of this 'old' structure as a functional organic building block for organic electronics applications have renewed interest in these molecules and their remarkable chemical and physical properties. Natural-origin indigos have been processed in fully bio-compatible field effect transistors, operating with ambipolar mobilities up to 0.5 cm(2) /Vs and air-stability. The synthetic derivative isoindigo has emerged as one of the most successful building-blocks for semiconducting polymers for plastic solar cells with efficiencies > 5%. Another isomer of indigo, epindolidione, has also been shown to be one of the best reported organic transistor materials in terms of mobility (∼2 cm(2) /Vs) and stability. This progress report aims to review very recent applications of indigoids in organic electronics, but especially to logically bridge together the hereto independent research directions on indigo, isoindigo, and other materials inspired by historical dye chemistry: a field which was the root of the development of modern chemistry in the first place.

  19. Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression

    PubMed Central

    Gusky, H. Chkourko; Diedrich, J.; MacDougald, O. A.; Podgorski, I.

    2016-01-01

    Summary A number of clinical studies have linked adiposity with increased cancer incidence, progression and metastasis, and adipose tissue is now being credited with both systemic and local effects on tumour development and survival. Adipocytes, a major component of benign adipose tissue, represent a significant source of lipids, cytokines and adipokines, and their presence in the tumour microenvironment substantially affects cellular trafficking, signalling and metabolism. Cancers that have a high predisposition to metastasize to the adipocyte-rich host organs are likely to be particularly affected by the presence of adipocytes. Although our understanding of how adipocytes influence tumour progression has grown significantly over the last several years, the mechanisms by which adipocytes regulate the meta-static niche are not well-understood. In this review, we focus on the omentum, a visceral white adipose tissue depot, and the bone, a depot for marrow adipose tissue, as two distinct adipocyte-rich organs that share common characteristic: they are both sites of significant metastatic growth. We highlight major differences in origin and function of each of these adipose depots and reveal potential common characteristics that make them environments that are attractive and conducive to secondary tumour growth. Special attention is given to how omental and marrow adipocytes modulate the tumour microenvironment by promoting angiogenesis, affecting immune cells and altering metabolism to support growth and survival of metastatic cancer cells. PMID:27432523

  20. Autoreactive T cells in endocrine/organ-specific autoimmunity: why has progress been so slow?

    PubMed

    Roep, Bart O

    2002-12-01

    It has been generally accepted that T cells play a critical role in endocrine autoimmune diseases. Immunotherapy aimed at T cells usually intervenes in the disease process. Yet, it has proven very difficult to identify the pathogenic T cells. This is partly caused by lack of measures to detect autoreactive T cells in a specific, sensitive and reproducible fashion as is achievable for determination of autoantibodies. There are, however, more explanations for the perhaps disappointing progress in this area: unlike autoantibodies, the relevant (disease-associated) autoreactive T cells act in the tissue lesion, and only circulate in very low precursor frequencies. Moreover, T cell autoreactivity is counteracted by various mechanisms of immune regulation. Candidate target autoantigens of T cells have been identified by autoantibodies, while there is little evidence that these autoantibodies are pathogenic. It is therefore conceivable that additional T cell targets exist. Finally, results from experimental animal models of endocrine autoimmunity have raised false expectations. Nonetheless, significant progress in our understanding of the contribution of (autoreactive) T cells to organ-specific destruction and autoimmune disease has been achieved. Although cross-sectional detection of autoreactive T cells bears little relevance to diagnosis, longitudinal studies have proven useful in determining the fate of islet implantation in type 1 diabetes patients, defined the immunological efficacy of immuno-intervention studies, and have led to definition of relevant target autoantigens and peptides that will help to monitor disease-associated autoimmunity. In conclusion, progress in the area of autoreactive T cells in the pathogenesis of type 1 diabetes may have seemed slow in the eyes of the beholder, but in fact, studies on T cells have contributed significantly to the unravelling of the pathogenic processes leading to the definition of appropriate targets for immuno-intervention.

  1. Recent progress in n-channel organic thin-film transistors.

    PubMed

    Wen, Yugeng; Liu, Yunqi

    2010-03-26

    Particular attention has been focused on n-channel organic thin-film transistors (OTFTs) during the last few years, and the potentially cost-effective circuitry-based applications in flexible electronics, such as flexible radiofrequency identity tags, smart labels, and simple displays, will benefit from this fast development. This article reviews recent progress in performance and molecular design of n-channel semiconductors in the past five years, and limitations and practicable solutions for n-channel OTFTs are dealt with from the viewpoint of OTFT constitution and geometry, molecular design, and thin-film growth conditions. Strategy methodology is especially highlighted with an aim to investigate basic issues in this field.

  2. Skin thickness progression rate: a predictor of mortality and early internal organ involvement in diffuse scleroderma

    PubMed Central

    Domsic, Robyn T; Rodriguez-Reyna, Tatiana; Lucas, Mary; Fertig, Noreen; Medsger, Thomas A

    2013-01-01

    Objective To examine the association of skin thickness progression rate (STPR) with mortality, and as a predictor of future internal organ involvement in an inception cohort of diffuse cutaneous systemic sclerosis (SSc) patients. Methods Diffuse cutaneous SSc patients older than 16 years of age evaluated at the University of Pittsburgh within 2 years of the first evidence of skin thickening between 1980 and 2005 were eligible. The authors calculated the STPR on these patients, and examined the relationship of this variable to the development of early internal organ involvement and short-term mortality using logistic regression. Results 826 patients were included in the analysis. Patients with a rapid STPR experienced significantly reduced short-term survival at 1 and 2 years from the time of first Pittsburgh evaluation (p=0.002). Patients with a rapid STPR were more likely to develop renal crisis within 1–2 years of follow-up. Rapid STPR was found to be an independent predictor of both mortality (OR 1.72; 95% CI 1.13 to 2.62; p=0.01) and ‘renal crisis’ (OR 2.05, 95% CI 1.10 to 3.85; p=0.02) within 2 years from first evaluation. Conclusion The STPR is an easy measure to perform at the time of initial evaluation for identifying those diffuse cutaneous SSc patients who are at increased risk of mortality and the development of renal crisis during the following 2 years. PMID:20679474

  3. An evaluability assessment of a West Africa based Non-Governmental Organization's (NGO) progressive evaluation strategy.

    PubMed

    D'Ostie-Racine, Léna; Dagenais, Christian; Ridde, Valéry

    2013-02-01

    While program evaluations are increasingly valued by international organizations to inform practices and public policies, actual evaluation use (EU) in such contexts is inconsistent. Moreover, empirical literature on EU in the context of humanitarian Non-Governmental Organizations (NGOs) is very limited. The current article focuses on the evaluability assessment (EA) of a West-Africa based humanitarian NGO's progressive evaluation strategy. Since 2007, the NGO has established an evaluation strategy to inform its maternal and child health care user-fee exemption intervention. Using Wholey's (2004) framework, the current EA enabled us to clarify with the NGO's evaluation partners the intent of their evaluation strategy and to design its program logic model. The EA ascertained the plausibility of the evaluation strategy's objectives, the accessibility of relevant data, and the utility for intended users of evaluating both the evaluation strategy and the conditions that foster EU. Hence, key evaluability conditions for an EU study were assured. This article provides an example of EA procedures when such guidance is scant in the literature. It also offers an opportunity to analyze critically the use of EAs in the context of a humanitarian NGO's collaboration with evaluators and political actors.

  4. Early Outgrowth Cells Release Soluble Endocrine Antifibrotic Factors That Reduce Progressive Organ Fibrosis

    PubMed Central

    Yuen, Darren A.; Connelly, Kim A.; Zhang, Yanling; Advani, Suzanne L.; Thai, Kerri; Kabir, Golam; Kepecs, David; Spring, Christopher; Smith, Christopher; Batruch, Ihor; Kosanam, Hari; Advani, Andrew; Diamandis, Eleftherios; Marsden, Philip A.; Gilbert, Richard E.

    2017-01-01

    Adult bone marrow-derived cells can improve organ function in chronic disease models, ostensibly by the release of paracrine factors. It has, however, been difficult to reconcile this prevailing paradigm with the lack of cell retention within injured organs and their rapid migration to the reticuloendothelial system. Here, we provide evidence that the salutary antifibrotic effects of bone marrow-derived early outgrowth cells (EOCs) are more consistent with an endocrine mode of action, demonstrating not only the presence of antifibrotic factors in the plasma of EOC-treated rats but also that EOC conditioned medium (EOC-CM) potently attenuates both TGF-β- and angiotensin II-induced fibroblast collagen production in vitro. To examine the therapeutic relevance of these findings in vivo, 5/6 subtotally nephrectomized rats, a model of chronic kidney and heart failure characterized by progressive fibrosis of both organs, were randomized to receive i.v. injections of EOC-CM, unconditioned medium, or 106 EOCs. Rats that received unconditioned medium developed severe kidney injury with cardiac diastolic dysfunction. In comparison, EOC-CM-treated rats demonstrated substantially improved renal and cardiac function and structure, mimicking the changes found in EOC-treated animals. Mass spectrometric analysis of EOC-CM identified proteins that regulate cellular functions implicated in fibrosis. These results indicate that EOCs secrete soluble factor(s) with highly potent antifibrotic activity, that when injected intravenously replicate the salutary effects of the cells themselves. Together, these findings suggest that an endocrine mode of action may underlie the effectiveness of cell therapy in certain settings and portend the possibility for systemic delivery of cell-free therapy. PMID:23922321

  5. Progress in Adsorption-Based CO2 Capture by Metal-Organic Frameworks

    SciTech Connect

    Liu, Jian; Thallapally, Praveen K.; McGrail, B. Peter; Brown, Daryl R.; Liu, Jun

    2012-01-01

    Metal-organic frameworks (MOFs) have recently attracted intense research interest because of their permanent porous structures, large surface areas, and potential applications as novel adsorbents. The recent progress in adsorption-based CO2 capture by MOFs is reviewed and summarized in this paper. CO2 adsorption in MOFs has been divided into two sections, adsorption at high pressures and selective adsorption at approximate atmospheric pressures. Keys to CO2 adsorption in MOFs at high pressures and low pressures are summarized to be pore volumes of MOFs, and heats of adsorption, respectively. Many MOFs have high CO2 selectivities over N2 and CH4. Water effects on CO2 adsorption in MOFs are presented and compared with benchmark zeolites. In addition, strategies appeared in the literature to enhance CO2 adsorption capacities and/or selectivities in MOFs have been summarized into three main categories, catenation and interpenetration, chemical bonding enhancement, and electrostatic force involvement. Besides the advantages, two main challenges for using MOFs in CO2 capture, the cost of synthesis and the stability toward water vapor, have been analyzed and possible solutions and path-forward have been proposed to address the two challenges as well.

  6. Recent progresses on materials for electrophosphorescent organic light-emitting devices.

    PubMed

    Xiao, Lixin; Chen, Zhijian; Qu, Bo; Luo, Jiaxiu; Kong, Sheng; Gong, Qihuang; Kido, Junji

    2011-02-22

    Although organic light-emitting devices have been commercialized as flat panel displays since 1997, only singlet excitons were emitted. Full use of singlet and triplet excitons, electrophosphorescence, has attracted increasing attentions after the premier work made by Forrest, Thompson, and co-workers. In fact, red electrophosphorescent dye has already been used in sub-display of commercial mobile phones since 2003. Highly efficient green phosphorescent dye is now undergoing of commercialization. Very recently, blue phosphorescence approaching the theoretical efficiency has also been achieved, which may overcome the final obstacle against the commercialization of full color display and white light sources from phosphorescent materials. Combining light out-coupling structures with highly efficient phosphors (shown in the table-of-contents image), white emission with an efficiency matching that of fluorescent tubes (90 lm/W) has now been realized. It is possible to tune the color to the true white region by changing to a deep blue emitter and corresponding wide gap host and transporting material for the blue phosphor. In this article, recent progresses in red, green, blue, and white electrophosphorescent materials for OLEDs are reviewed, with special emphasis on blue electrophosphorescent materials.

  7. [Progress in engineering Escherichia coli for production of high-value added organic acids and alcohols].

    PubMed

    Wang, Jiming; Liu, Wei; Xu, Xin; Zhang, Haibo; Xian, Mo

    2013-10-01

    Confronted with the gradual exhaustion of the earth's fossil energy resources and the grimmer environmental deterioration, the bio-based process to produce high-value added platform chemicals from renewable biomass is attracting growing interest. Escherichia coli has been chosen as a workhouse for the production of many valuable chemicals due to various advantages, such as clear genetic background, convenient to be genetically modified and good growth properties with low nutrient requirements. Rational strain development of E. coli achieved by metabolic engineering strategies has provided new processes for efficiently biotechnological production of various high-value chemical building blocks. This review focuses on recent progresses in metabolic engineering of E. coli that lead to efficient recombinant biocatalysts for production of high-value organic acids such as succinic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like glycerol and xylitol. Besides, this review also discusses several other platform chemicals, including 2,5-furan dicarboxylic acid, aspartic acid, glutamic acid, itaconic acid, levulinic acid, 3-hydroxy-gamma-butyrolactone and sorbitol, which have not been produced by E. coli until now.

  8. Flammable Gas Safety Program: actual waste organic analysis FY 1996 progress report; Flammable Gas Safety Program: actual waste organic analysis FY 1996 progress report

    SciTech Connect

    Clauss, S.A.; Grant, K.E.; Hoopes, V.; Mong, G.M.; Rau, J.; Steele, R.; Wahl, K.H.

    1996-09-01

    This report describes the status of optimizing analytical methods to account for the organic components in Hanford waste tanks, with emphasis on tanks assigned to the Flammable Gas Watch List. The methods developed are illustrated by their application to samples from Tanks 241-SY-103 and 241-S-102. Capability to account for organic carbon in Tank SY-101 was improved significantly by improving techniques for isolating organic constituents relatively free from radioactive contamination and by improving derivatization methodology. The methodology was extended to samples from Tank SY-103 and results documented in this report. Results from analyzing heated and irradiated SY-103 samples (Gas Generation Task) and evaluating methods for analyzing tank waste directly for chelators and chelator fragments are also discussed.

  9. Selective transformation of carbonyl ligands to organic molecules. Progress report, September 1, 1989--November 14, 1992

    SciTech Connect

    Cutler, A.R.

    1992-05-12

    Studies on the carbonylation of ({eta}{sup 5}-indenyl)(L)(CO)Ru-R complexes (L = CO, PPh{sub 3}; R = CH{sub 2}OMe, CH{sub 3}) have been completed. Particularly noteworthy is that the methoxymethyl complexes readily transform to their acyl derivatives under mild conditions that leave their iron congeners inert towards CO. Surprisingly, even ({eta}{sup 5}-indenyl)(PPh{sub 3}){sub 2}Ru-CH{sub 3} carbonylates and gives ({eta}{sup 5}-indenyl)(PPh{sub 3})(CO)Ru-C(O)CH{sub 3}. Mechanistic studies on the ``non catalyzed`` hydrosilation of the manganese acyls (CO){sub 5}Mn-C(O)CH{sub 2}R (R = H, OCH{sub 3}, CH{sub 3}) with Et{sub 3}SiH and of cobalt acetyls (CO){sub 3}(PR{sub 3})CoC(O)CH{sub 3} with several monohydrosilanes have been completed. The cobalt acetyls cleanly give ethoxysilanes (not acetaldehyde), and the manganese acyls provide {alpha}-siloxyvinyl complexes Z-(CO){sub 5}Mn-C(OSiEt{sub 3})=CHR (R = H, CH{sub 3}, OCH{sub 3}). Carbonylation and protolytic cleavage of the latter generate pyruvoyl complexes (CO){sub 5}Mn-COCOR (R = CH{sub 3}, CH{sub 2}CH{sub 3}), formally the products of net ``double carbonylation`` sequences. Studies in progress are concerned with how manganese complexes as diverse as (CO){sub 5}Mn-Y [Y = C(O)R, R, BR - but not SiMe{sub 3} or Mn(CO){sub 5}] and ({eta}{sup 3}-C{sub 3}H{sub 5})Mn(CO){sub 2}L [but not CpMn(CO){sub 3} or CpMn(CO){sub 2}({eta}{sup 2}HSiR{sub 3})] function as efficient hydrosilation catalysts towards Cp(CO){sub 2}FeC(O)CH{sub 3}, for example. These reactions cleanly afford fully characterized {alpha}-siloxyethyl complexes Fp-CH(OSiR{sub 3})CH{sub 3} under conditions where typically Rh(1) hydrosilation catalysts are inactive. Several of these manganese complexes also catalytically hydrosilate organic esters, including lactones, to their ethers R-CH{sub 2}OR; these novel ester reductions occur quantitatively at room temperature and appear to be general in scope.

  10. Current progress in public health models addressing the critical organ shortage.

    PubMed

    Shanmugarajah, Kumaran; Villani, Vincenzo; Madariaga, Maria Lucia L; Shalhoub, Joseph; Michel, Sebastian G

    2014-12-01

    Since its inauguration in 1954, the field of modern transplantation has made great strides in surgical technique, the prevention of acute and chronic rejection, the minimization of immunosuppression-related side-effects and transplant tolerance. As such, organ transplantation is used worldwide as a curative, life-saving treatment for people with end-stage organ failure. However, the successes of organ transplantation have resulted in the number of patients on transplant waiting lists far exceeding the number of organs available, with growing numbers of patients dying while awaiting transplants. In order to address this critical organ shortage, a number of legislative changes have been implemented worldwide to increase the number of individuals registering as organ donors. These have included presumed consent donation, incentivized organ donation, commercial organ transplantation and mandated choice models. This article will address these public health policies in turn. The implementation of these strategies and the evidence for their efficacy will be evaluated. Based on this, we have identified that well-supported transplant coordinators approaching next-of-kin, incentives and public health campaigns are key factors that increase organ donation. Finally we propose a modified mandated choice model that may be an alternative option to maximize the number of available organs for transplantation.

  11. Development and applications of photosensitive device systems to studies of biological and organic materials. Progress report

    SciTech Connect

    Not Available

    1984-01-01

    The purpose was to develop and improve appropriate experimental techniques to the point where they could be applied to specific classes of biological problems. Progress is reported in the following areas: (1) area detectors; (2) x-ray diffraction studies of membranes; (3) electron transfer in loosely coupled systems; (4) bioluminescence and fluorescence; and (5) sonoluminescence. (ACR)

  12. Role of bacteria in organic matter fluxes in the Southern California Coastal Zone: (Progress report)

    SciTech Connect

    Not Available

    1988-07-01

    The fate of organic matter in the sea, whether produced in situ or introduced from land, is greatly influenced by the metabolic trophic activities of the resident biota. Until recently it was thought that much of the primary production is consumed by the herbivores, making them the main determinants of fate of organic matter. It now appears that the microbial component of marine foodweb also plays a significant role in the decomposition, distribution, and vertical flux of organic material in seawater. The goal of the proposed research is to quantify this role of the microbial foodweb as part of a DOE-sponsored interdisciplinary study. We are testing the hypothesis that organic matter utilization by heterotrophic bacterioplankton represents a major sink for organic matter in the Southern California Coastal Zone.

  13. Recent progress on thin-film encapsulation technologies for organic electronic devices

    NASA Astrophysics Data System (ADS)

    Yu, Duan; Yang, Yong-Qiang; Chen, Zheng; Tao, Ye; Liu, Yun-Fei

    2016-03-01

    Among the advanced electronic devices, flexible organic electronic devices with rapid development are the most promising technologies to customers and industries. Organic thin films accommodate low-cost fabrication and can exploit diverse molecules in inexpensive plastic light emitting diodes, plastic solar cells, and even plastic lasers. These properties may ultimately enable organic materials for practical applications in industry. However, the stability of organic electronic devices still remains a big challenge, because of the difficulty in fabricating commercial products with flexibility. These organic materials can be protected using substrates and barriers such as glass and metal; however, this results in a rigid device and does not satisfy the applications demanding flexible devices. Plastic substrates and transparent flexible encapsulation barriers are other possible alternatives; however, these offer little protection to oxygen and water, thus rapidly degrading the devices. Thin-film encapsulation (TFE) technology is most effective in preventing water vapor and oxygen permeation into the flexible devices. Because of these (and other) reasons, there has been an intense interest in developing transparent barrier materials with much lower permeabilities, and their market is expected to reach over 550 million by 2025. In this study, the degradation mechanism of organic electronic devices is reviewed. To increase the stability of devices in air, several TFE technologies were applied to provide efficient barrier performance. In this review, the degradation mechanism of organic electronic devices, permeation rate measurement, traditional encapsulation technologies, and TFE technologies are presented.

  14. Organic Tank Safety Project: Equilibrium moisture determination task fiscal year 1997. Annual progress report

    SciTech Connect

    Scheele, R.D.; Bredt, P.R.; Sell, R.L.

    1997-09-01

    Twenty waste storage tanks at the U.S. Department of Energy`s Hanford Site are included in the Organic Tank Watch List. The water content in the wastes plays a significant role in preventing propagating or sustainable chemical reactions, and the fuel and energetics independent safety criterion has been determined to be 20 wt % water. To ensure that the organic-bearing wastes continue to be stored safely, Duke Engineering and Services Hanford commissioned the Pacific Northwest National Laboratory to investigate the effect of water partial pressure (P{sub H2O}) on the water content of organic-bearing or representative wastes. If necessary, the P{sub H2O} could be managed to maintain the water content at an acceptable level or adjust the water content back to an acceptable level. During fiscal year 1997, the effect of P{sub H2O} was tested to determine how organic-bearing wastes will respond if exposed to environmental Hanford water partial pressures or other potential water partial pressures. The samples tested were obtained from Organic Watch List Tanks, tanks that D.A. Reynolds of Lockheed Martin Hanford suspects may contain wastes having significant organic content, or wastes characteristic of organic-bearing wastes. Temperatures at or near maximum tank waste surface temperatures were used in the tests. At 26{degrees}C, the lowest temperature used, the water partial pressures used in the tests ranged from 2 to 22 torr. At 41{degrees}C, the highest temperature used, the water partial pressures used ran ed from 3.5 to 48 torr.

  15. Development of gas chromatographic system for dissolved organic carbon analysis in seawater. Annual progress report

    SciTech Connect

    Chipman, D.W.; Takahashi, T.

    1992-12-01

    During the first six months of this two-year grant, we have completed the construction of the analytical portion of a prototype gas chromatograph-based system for the analysis of dissolved organic carbon in seawater. We also have begun testing the procedures to be used to cryogenically concentrate and transfer carbon dioxide from the oxidizing atmosphere of the high-temperature furnace into the reducing hydrogen carrier gas of the gas chromatograph. During the second half of the first year, we will construct the high-temperature catalytic oxidation furnace and test the entire system on laboratory-prepared aqueous solutions of various organic compounds. Also during this period, we will take part in an initial scoping study within the Cape Hatteras field area on board the R/V Gyre. This study will involve both the collection of samples of seawater for organic and inorganic carbon analysis and the measurement of surface-water pCO{sub 2}.

  16. Calcium sulfate solubility in organic-laden wastewater. Progress report, September 1981-December 1982

    SciTech Connect

    Banz, I.; Luthy, R.G.

    1982-12-01

    The purpose of this investigation was to determine the solubility of calcium sulfate in wastewaters, and to examine the effect of organic constituents in wastewater and in synthetic waters on calcium sulfate solubility. The study entailed both laboratory experiments and chemical equilibria computer modeling. The calcium sulfate solubility product in a solvent-extracted, ammonia-stripped coal gasification wastewater was found to be 3.65 x 10/sup -5/ M/sup 2/; this is 45% higher than that observed in clean water. Wastewater treated further by activated carbon adsorption showed the solubility product of calcium sulfate to be 2.87 x 10/sup -5/ M/sup 2/. This is only 14% higher than that observed in clean water; this indicates that organic material removed in the adsorption process may be responsible for enhanced solubility in wastewater. Synthetic wastewaters were prepared using humic-like organic compounds, since it was believed that humic-like material accounted for a major fraction of the residual organic carbon content of solvent-extracted coal gasification wastewater. Calcium sulfate solubility in oxidized samples of resorcinol, catechol, and tannic acid showed little difference from that in clean water. In humic acid, however, the calcium sulfate solubility product was 47% higher than in clean water; this increase in solubility product was similar to that observed in pretreated wastewater, indicating that a complex organic material is responsible for the increase in solubility. These results imply that calcium and organic constituents in wastewater form a chemical complex which has the effect of increasing total calcium in solution without preciptating calcium sulfate. Thus higher levels of calcium and sulfate may be maintained in wastewaters destined for reuse in recirculating cooling waters than would be indicated by considering only inorganic chemical interactions. 51 references, 18 figures, 40 tables.

  17. Progress Report for Activities of the U. S. Burning Plasma Organization

    SciTech Connect

    Van Dam, James W

    2009-04-07

    This report describes the activities of the past year of the U. S. Burning Plasma Organization (USBPO), a national organization of scientists involved in researching the properties of magnetically confined burning fusion plasmas. Its main activities are the coordination, facilitation, and promotion of research activities in the U. S. fusion energy sciences program relevant to burning plasma science and, specifically, of preparations for U. S. participation in the international ITER experiment. Specifically, the USBPO mission is to advance the scientific understanding of burning plasmas and to ensure the greatest benefit from a burning plasma experiment by coordinating relevant U. S. fusion research with broad community participation.

  18. [Physicochemical and microbiological factors influencing the bioavailability of organic contaminants in subsoils]. Progress report, [July 1, 1992--June 30, 1993

    SciTech Connect

    Not Available

    1992-12-31

    We report progress in elucidating the microbiological variables important in determining the relative success of bacteria in utilizing soil-sorbed contaminants. Two bacterial species, Pseudomonas putida (ATCC 17484) and an Alcaligenes sp. isolated from petroleum contaminated soil are known to differ markedly in their ability to utilize soil-sorbed napthalene based on a kinetic comparison of their capability of naphthalene mineralization in soil-containing and soil-free systems. The kinetic analysis led us to conclude that strain 17484 had direct access to naphthalene present in a labile sorbed state which promoted the rapid desorption of naphthalene from the non-labile phase. Conversely, both the rate and extent of naphthalene mineralization by strain NP-Alk suggested that this organism had access only to naphthalene in solution. Desorption was thus limited and the efficiency of total naphthalene removal from these soil slurries was poor. These conclusions were based on the average activities of cells in soil slurries without regard for the disposition of the organisms with respect to the sorbent. Since both organisms degrade naphthalene by apparently identical biochemical pathways, have similar enzyme kinetic properties, and are both motile, gram negative organisms, we undertook a series of investigations to gain a better understanding of what microbiological properties were important in bioavailability.

  19. Use of sonication for in-well softening of semivolatile organic compounds. 1997 annual progress report

    SciTech Connect

    Peters, R.W.; Manning, J.; Hoffman, M.R.; Gorelick, S.

    1997-01-01

    'This project investigates the in-situ degradation of semivolatile organic compounds (SVOCs) and volatile organic compounds (VOCs) using in-well sonication, in-well vapor stripping, and bioremediation. Pretreating groundwaters with sonication techniques in-situ would form VOCs that can be effectively removed by in-well vapor stripping and bioremediation. The mechanistic studies focus on the coupling of megasonics and ultrasonics to soften (i.e., partially degrade) the SVOCs; oxidative reaction mechanism studies; surface corrosion studies (on the reactor walls/well); enhancement due to addition of oxidants, quantification of the hydroxyl radical formation; identification/quantification of degradation products; volatility/degradability of the treated waters; development of a computer simulation model to describe combined in-well sonication/in-well vapor stripping/bioremediation; systems analysis/economic analysis; large laboratory-scale experiment verification; and field demonstration of the integrated technology. Benefits of this approach include: (1) Remediation is performed in-situ; (2) The treatment systems complement each other; their combination can drastically reduce or remove SVOCs and VOCs; (3) Ability to convert hard-to-degrade organics into more volatile organic compounds; (4) Ability to remove residual VOCs and softened SVOCs through the combined action of in-well vapor stripping and biodegradation; (5) Does not require handling or disposing of water at the ground surface; and (6) Cost-effective and improved efficiency, resulting in shortened clean-up times to remediate a site.'

  20. The solubilities of significant organic compounds in HLW tanks upernate solutions - FY 1997 progress report

    SciTech Connect

    Barney, G.S.

    1997-09-16

    The solubilities of seven sodium salts of organic acids that are thought to exist in high-level waste at the Hanford Site were measured in tank supernatant simulant solutions during FY 1997. This solubility information will be used to determine if these organic salts could exist in solid phases (saltcake or sludges) in the waste where they might react violently with the nitrate or nitrite salts present in the tanks. The solubility of sodium acetate was measured in simulated waste supernate solutions at 25C, 30C, 40C, and 50C that were both unsaturated and saturated with sodium nitrate. Solubilities of sodium glycolate, citrate, ethylenediaminetetraacetate (EDTA), nitrilotriacetate (NTA), formate, and oxalate were measured in simulated waste supernate solutions that were saturated with sodium nitrate. In addition, solubilities of sodium EDTA, citrate, glycolate, and NTA were measured in a complex waste matrix. The organic compounds were selected because they are expected to exist in relatively high concentrations in the tanks. The solubilities of sodium glycolate citrate, EDTA, NTA, and formate were high over the temperature and sodium hydroxide concentration ranges expected in the tanks. The solubility of sodium oxalate in solutions saturated with sodium nitrate were quite low. The presence of additional sodium in the waste simulant solutions that were saturated with sodium nitrate slightly lowered the solubilities of each of the organic salts. Solubilities were, however, high enough to prevent solid sodium salts of all the organic acids from precipitating from tank supernate solutions, except for sodium oxalate. The total organic carbon concentrations (TOC) of actual tank supernates are generally much lower than the TOC ranges for the simulated supernate solutions saturated (at the solubility limit) with the organic salts. This is true even if all the dissolved carbon in a given tank supernate is due to only one of these soluble compounds (an unlikely situation

  1. Membrane boenergetics of salt tolerant organisms. Progress report, June 1993--June 1995

    SciTech Connect

    Lanyi, J.K.

    1996-06-01

    Substantial progress was made on describing the pathway of the transported proton in bacteriorhodopsin, and the thermodynamics of the proton transfers. The underlying principle of the transport was identified as the alternating access of the retinal Schiff base toward the two membrane surfaces, regulated by electrostatic interaction between the retinylidene nitrogen and its counterion. Consistent with a shared transport mechanism for both retinal proteins, bacteriorhodopsin was converted into a balorhodopsin-like chloride pump by replacing asp-85 with threonine. This region is thereby identified as the active site that determines ion specificity. Description of the metal ion-dependent kinetics of the ATP hydrolysis provided clues to the structure of active site in the halobacterial ATPase.

  2. Total light loss optic spectroscopy. Progress towards a fiber optic Raman organic vapor sensor

    SciTech Connect

    Kyle, K.R.; Vess, T.M.; Angel, S.M.

    1993-09-01

    A Raman probe has been developed utilizing a single optical fiber as both a light pipe and an active sensing element. By coating a small segment of the surface of an exposed glass fiber core with a thin polymer film, an inverted waveguide is formed where light transmitted down the fiber is stripped out of the core and into the polymer film. The polymer coating is used both as a waveguide and as a medium for concentrating small organic molecules to be interrogated by Raman spectroscopy. The ability of the fiber optic thin film waveguide probe to detect organic vapors is demonstrated. The utility of the probe in the detection of nonaqueous phase liquids (NAPLs) is also described.

  3. Dimethyl Sulfoxide Perturbs Cell Cycle Progression and Spindle Organization in Porcine Meiotic Oocytes

    PubMed Central

    Li, Xuan; Wang, Yan-Kui; Song, Zhi-Qiang; Du, Zhi-Qiang; Yang, Cai-Xia

    2016-01-01

    Meiotic maturation of mammalian oocytes is a precisely orchestrated and complex process. Dimethyl sulfoxide (DMSO), a widely used solvent, drug, and cryoprotectant, is capable of disturbing asymmetric cytokinesis of oocyte meiosis in mice. However, in pigs, DMSO’s effect on oocyte meiosis still remains unknown. We aimed to evaluate if DMSO treatment will affect porcine oocyte meiosis and the underlying molecular changes as well. Interestingly, we did not observe the formation of the large first polar body and symmetric division for porcine oocytes treated with DMSO, contrary to findings reported in mice. 3% DMSO treatment could inhibit cumulus expansion, increase nuclear abnormality, disturb spindle organization, decrease reactive oxygen species level, and elevate mitochondrial membrane potential of porcine oocytes. There was no effect on germinal vesicle breakdown rate regardless of DMSO concentration. 3% DMSO treatment did not affect expression of genes involved in spindle organization (Bub1 and Mad2) and apoptosis (NF-κB, Pten, Bcl2, Caspase3 and Caspase9), however, it significantly decreased expression levels of pluripotency genes (Oct4, Sox2 and Lin28) in mature oocytes. Therefore, we demonstrated that disturbed cumulus expansion, chromosome alignment, spindle organization and pluripotency gene expression could be responsible for DMSO-induced porcine oocyte meiotic arrest and the lower capacity of subsequent embryo development. Our results provide new insights on DMSO’s effect on porcine oocyte meiosis and raise safety concerns over DMSO’s usage on female reproduction in both farm animals and humans. PMID:27348312

  4. Organic sensitizers for dye-sensitized solar cell (DSSC): Properties from computation, progress and future perspectives

    NASA Astrophysics Data System (ADS)

    Obotowo, I. N.; Obot, I. B.; Ekpe, U. J.

    2016-10-01

    The advent of the dye-sensitized solar cells (DSSCs) came at a time when the quest for alternative energy was high, replacing p-n junction photovoltaic devices. Its uniqueness arises from the fact that unlike the conventional systems where the semiconductor assumes the task of light absorption and charge transport, the two functions are separated in DSSC. Organic sensitizers have been used to harvest a large fraction of sunlight ranging from the UV region to the near infrared region of the spectrum leading to power conversion efficiencies of up to ∼ 10.65 % for metal-free organic sensitizers. Currently, experimental analysis of photo sensitizers utilized in DSSCs is often a trial and error process, often laborious and require extensive and expensive chemical synthesis. In most cases, disappointing results from late-stage of the dye synthesis indicate an urgent need to understand the properties of the dyes at a molecular level, before experiments take place. Fortunately, the use of quantum chemical calculations especially Density Functional Theory (DFT) to screen potential dyes has helped in developing efficient sensitizers and to reduce cost. In the present review article, we discuss the current state of the field, new concepts, design strategies, challenges facing the theoretical design and development of organic sensitizers for DSSCs and future perspectives.

  5. Immobilized enzymes in organic media: Determinants of water dependence. Progress statement

    SciTech Connect

    Nandi, S.; DeFilippi, I.; Bedwell, B.; Zemel, H.

    1994-08-01

    The overall goals of this project are to investigate the critical factors that limit commercial scale applications of enzymes in organic solvents, and to scale-up a process for the production of a precursor to a specialty polymer. The overall performance of an immobilized enzyme can be influenced by its intrinsic structure and by external factors such as water content, support, pH, etc.. We have investigated the interrelation between support morphology and water content, and its effect on overall enzyme performance. Using a lipase catalyzed inter-esterification reaction as a model, we studied the controlling factors when water content in the organic solvent is such that a micro-aqueous phase is formed. In such an environment it was found that support particle aggregation is the major cause for decline in enzyme activity. We have shown that particle porosity, as well as the use of a particular non-woven fabric as an enzyme support, could alleviate this problem. These findings are being translated into a bioreactor design. We have also studied two {open_quotes}dry{close_quotes} non-aqueous systems, where a water phase is not formed since the water content is below its solubility in the organic solvent. In one of the systems, Subtilisin catalyzed trans-esterification of vinyl acrylate with a chiral alcohol, we have demonstrated that the use of a proprietary fabric support provides a significant boost in enzyme activity. We suggest that this particular fabric with its hydrophilic fibers acts as a lyoprotectant in the process of drying the enzyme. The benefits of this material as an enzyme support and its use in a lab scale bioreactor are being studied. Preliminary experiments have also been performed with a second {open_quotes}dry{close_quotes} reaction. This is the lipase catalyzed synthesis of AlliedSignal`s new product, VEctomer 4010.

  6. Kif2a regulates spindle organization and cell cycle progression in meiotic oocytes

    PubMed Central

    Yi, Zi-Yun; Ma, Xue-Shan; Liang, Qiu-Xia; Zhang, Teng; Xu, Zhao-Yang; Meng, Tie-Gang; Ouyang, Ying-Chun; Hou, Yi; Schatten, Heide; Sun, Qing-Yuan; Quan, Song

    2016-01-01

    Kif2a is a member of the Kinesin-13 microtubule depolymerases. Here, we report the expression, subcellular localization and functions of Kif2a during mouse oocyte meiotic maturation. Immunoblotting analysis showed that Kif2a was gradually increased form GV to the M I stages, and then decreased slightly at the M II stage. Confocal microscopy identified that Kif2a localized to the meiotic spindle, especially concentrated at the spindle poles and inner centromeres in metaphase and translocated to the midbody at telophase. Kif2a depletion by siRNA microinjection generated severely defective spindles and misaligned chromosomes, reduced microtubule depolymerization, which led to significant pro-M I/M Iarrest and failure of first polar body (PB1) extrusion. Kif2a-depleted oocytes were also defective in spindle pole localization of γ-tubulin and showed spindle assembly checkpoint (SAC) protein Bub3 at the kinetochores even after 10 hr extended culture. These results demonstrate that Kif2a may act as a microtubule depolymerase, regulating microtubule dynamics, spindle assembly and chromosome congression, and thus cell cycle progression during mouse oocyte meiotic maturation. PMID:27991495

  7. Photooxidation of organic wastes using semiconductor nanoclusters. 1998 annual progress report

    SciTech Connect

    Wilcoxon, J.P.

    1998-06-01

    'This report summarizes work after 1.5 years of a 3-year project. The authors efforts have focused on demonstration of photocatalysis of organic pollutants using nanosize MoS{sub 2}. They investigated the effects of (1) bandgap, valence and conduction band energies; (2) surface modification of MoS{sub 2} by deposition of metal and metal oxide islands to enhance electron transfer; and (3) use of semi-conductor semi-conductor composites to achieve improved charge separation and thus photooxidation of pollutants. They synthesized and studied nanosize MoS{sub 2} of three different sizes and associated bandgaps and studied photoredox reactions of nanosize MoS{sub 2} dispersed in solution and supported on a macroscopic powder. The latter would be the method of choice for use as a practical photocatalyst for water purification. As they emphasized in the original proposal, MoS{sub 2} in nanosize form can be tuned to absorb various amounts of the solar spectrum. They discovered there is an optimal choice of absorbance characteristics and valence and conduction band levels which allow the rapid photo-oxidation of a chosen organic molecule. The advantages of having a photostable material with a tunable bandgap were demonstrated in an experiment where phenol destruction with visible (> 450 nm) light occurred at a dramatically faster rate with nanoscale MoS{sub 2} catalysts compared to the best available previous material TiO{sub 2}. This was the first demonstration of rapid photooxidation of an organic molecule using a completely photostable catalyst and only visible light. The possibility of transferring electrons or holes between nanoscale MoS{sub 2} and other semiconductor materials in order to increase electron/hole lifetimes were explored. It was shown that small amounts (<5 weight %) of nanoscale MoS{sub 2} deposited on to TiO{sub 2} can lead to significant ({approximately}2) enhancements of phenol destruction rates. A number of different chemicals were photocatalyzed

  8. Y-12 Development Organization technical progress report: Part 3 -- Metal processing, period ending March 1, 1994

    SciTech Connect

    Northcutt, W.G. Jr.

    1994-05-26

    As part of the effort to downsize its uranium processing facilities, the Y-12 Plant has supported an investigation to identify extraction solvents that would both work efficiently in centrifugal contactors and be disposed of easily. Various organic ethers, hydroxy ethers, ether ketones, acids, amides, and diketones were studied for their ability to extract uranyl nitrate from aqueous solutions. Although many of these solvents were obtained commercially, others had to be synthesized in-house. The authors found a large range of extraction coefficients for these solvents. Because of steric hindrance or some other factor, certain ethers performed poorly. On the other hand, various mono- and diethers of tetrahydrofurfuryl alcohol exhibited excellent extraction and stripping coefficients for uranyl nitrate, justifying purchase of a pilot plant batch of one of this family of solvents. Likewise, the authors determined the extraction coefficient for one of the two amides synthesized in-house to be quite high.

  9. Bronchiolitis obliterans organizing pneumonia: clinicopathologic review of a series of 45 Korean patients including rapidly progressive form.

    PubMed Central

    Chang, Joon; Han, Joungho; Kim, Dong Won; Lee, Inchul; Lee, Kyo Young; Jung, Soonhee; Han, Hye Seung; Chun, Bong Kwon; Cho, Seong Jin; Lee, Kibeom; Lim, Beom Jin; Shin, Dong Hwan

    2002-01-01

    Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathological syndrome associated with a variety of disease entities. The aim of this study was to review cases with initial diagnosis of BOOP applying uniform histopathologic criteria, and analyze the clinical characteristics of proven cases of BOOP including rapidly progressive form. A total of 81 cases, initially diagnosed as BOOP and with available tissue sections, was collected. Thirty six cases (44.4%) were excluded from the study, more than two thirds of which were given a revised diagnosis of interstitial pneumonitis/fibrosis other than BOOP. Thirty one patients were classified as idiopathic BOOP, 8 patients as secondary BOOP, and 6 patients as rapidly progressive BOOP. Open lung biopsy specimen from all six cases with lethal outcome showed more severe interstitial inflammation and septal fibrosis and/or alveolar exudate with a varying degree than those with good prognosis. There was no difference by the sexes. The two most frequent presenting symptoms were cough and dyspnea. Bilateral multifocal consolidation was a common radiological finding. More than 70% cases of idiopathic BOOP experienced clinical improvements. The diagnosis of BOOP is usually suggested by clinicoradiologic findings, but needs to be confirmed histopathologically, preferably through surgical open or video-assisted thoracoscopic biopsy. PMID:11961300

  10. Photocatalytic and chemical oxidation of organic compounds in supercritical carbon dioxide. Progress report for FY97

    SciTech Connect

    Blake, D.M.; Bryant, D.L.; Reinsch, V.

    1997-09-30

    'The background for the project is briefly reviewed and the work done during the nine months since funding was received is documented. Work began in January, 1997. A post doctoral fellow joined the team in April. The major activities completed this fiscal year were: staffing the project, design of the experimental system, procurement of components, assembly of the system. preparation of the Safe Operating Procedure and ES and H compliance, pressure testing, establishing data collection and storage methodology, and catalyst preparation. Objective The objective of the project is to develop new chemistry for the removal of organic contaminants from supercritical carbon dioxide. This has application in processes used for continuous cleaning and extraction of parts and waste materials. A secondary objective is to increase the fundamental understanding of photocatalytic chemistry. Cleaning and extraction using supercritical carbon dioxide (scCO{sub 2}) can be applied to the solution of a wide range of environmental and pollution prevention problems in the DOE complex. Work is being done that explores scCO{sub 2} in applications ranging from cleaning contaminated soil to cleaning components constructed from plutonium. The rationale for use of scCO{sub 2} are based on the benign nature, availability and low cost, attractive solvent properties, and energy efficient separation of the extracted solute from the solvent by moderate temperature or pressure changes. To date, R and D has focussed on the methods and applications of the extraction steps of the process. Little has been done that addresses methods to polish the scCO{sub 2} for recycle in the cleaning or extraction operations. In many applications it will be desirable to reduce the level of contamination from that which would occur at steady state operation of a process. This proposal addresses chemistry to achieve that. This would be an alternative to removing a fraction of the contaminated scCO{sub 2} for disposal

  11. Teachers Union Organizes Members to Enforce AHERA Law--A Work in Progress.

    PubMed

    Sireci, Michael P; Levenstein, Charles; Gibson, Sarah

    2016-05-01

    The Massachusetts Teachers Association's Environmental Health and Safety Committee is using a number of approaches to evaluate and improve the enforcement of the U.S. Asbestos Hazard Emergency Response Act legislation intended to ensure the proper management of asbestos in public buildings, including schools. The committee first approached state regulators directly concerning enforcement concerns, with limited success. Next, the Massachusetts Teachers Association developed an organizing strategy and a curriculum focusing on the requirements of the Asbestos Hazard Emergency Response Act and on building a membership-run health and safety committee infrastructure in local unions. Five trainings took place throughout Massachusetts over a 2-month period in 2015. The committee implemented follow-up procedures and support for locals to continue to engage in this ongoing effort. This work illustrates that the passage of the Asbestos Hazard Emergency Response Act in 1986 was insufficient action to remediate school asbestos exposures. It is necessary for unions representing school employees to systematically hold regulators and school districts accountable for enforcement and compliance.

  12. Recent progress on application of UV excilamps for degradation of organic pollutants and microbial inactivation.

    PubMed

    Matafonova, Galina; Batoev, Valeriy

    2012-10-01

    Excilamps as modern mercury-free sources of narrow-band UV radiation represent an attractive alternative in environmental applications. This review focuses on recent studies on the water and surface decontamination with excilamps by means of direct photolysis and advanced oxidation processes. To date, direct photolysis and advanced oxidation processes (AOPs) such as UV/H(2)O(2), UV/Fenton and UV/O(3) have been applied for degradation of organic compounds (mainly, phenols, dyes and herbicides) in model aqueous solutions. Special emphasis is placed on studies combining UV irradiation (as a pre-treatment or post-treatment step) with biological treatment. In this review, the efficiencies of direct UV, UV/H(2)O(2) and UV/TiO(2) processes for inactivation of a variety of pathogenic microorganisms in water and on surfaces are discussed. The analysis of the literature shows that more works need to be done on scaling up the processes, degradation/mineralization of target pollutant(s) in real effluents and evaluation of energy requirements.

  13. Liquid chromatographic determination of organic nitrogenous bases in dosage forms: a progress report.

    PubMed

    Walker, S T

    1985-01-01

    A liquid chromatographic (LC) method has been developed as a general procedure for the assay of the salts of organic nitrogenous bases in a variety of dosage forms. The method uses a nitrile-bonded reverse phase column, a methanol-0.003M ammonium acetate (90 + 10) mobile phase, and photometric detection at 254 nm. The sample is dissolved in the mobile phase and an aliquot is injected through a 20 microL injection loop. Average recovery values for duplicate assays were chlorpheniramine maleate injection 97.8%, chlorpheniramine maleate tablets 99.1%, cyclizine hydrochloride tablets 100.0%, doxylamine succinate tablets 103.3%, mesoridazine besylate tablets 100.4%, pentazocine hydrochloride tablets 103.0%, promethazine hydrochloride injection 98.4%, protriptyline hydrochloride tablets 101.2%, pyrilamine maleate tablets 97.8%, pyrimethamine tablets 100.0%, tripelennamine citrate elixir 100.0%, and tripelennamine hydrochloride tablets 97.2%. Results by this method were in good agreement with those obtained by the USP XX method. This study, which is being continued, will be expanded to include additional drugs.

  14. Organization and control of genes encoding catabolic enzymes in Rhizobiaceae. Progress report, March 1993

    SciTech Connect

    Parke, D.; Ornston, L.N.

    1993-03-01

    Rhizobiaceae, a diverse bacterial group comprising rhizobia and agrobacteria, symbiotic partnership with plants form nitrogen-fixing nodules on plant roots or are plant pathogens. Phenolic compounds produced by plants serve as inducers of rhizobial nodulation genes and agrobacterial virulence genes reflect their capacity to utilize numerous aromatics, including phenolics, as a source of carbon and energy. In many microbes the aerobic degradation of numerous aromatic compounds to tricarboxylic acid cycle intermediates is achieved by the {beta}-ketoadipate pathway. Our initial studies focused on the organization and regulation of the ketoadipate pathway in Agrobacterium tumefaciens. We have cloned, identified and characterized a novel regulatory gene that modulates expression of an adjacent pca (protocatechuate) structural gene, pcaD. Regulation of pcaD is mediated by the regulatory gene, termed pcaQ, in concert with the intermediate {beta}-carboxy-cis,cis-muconate. {beta}-carboxy-cis,cismuconate is an unstable chemical, not marketed commercially, and it is unlikely to permeate Escherichia coli cells if supplied in media. Because of these factors, characterization of pcaQ in E. coli required an in vivo delivery system for {beta}-carboxycis,cis-muconate. This was accomplished by designing an E. coli strain that expressed an Acinetobacter calcoaceticus pcaA gene for conversion of protocatechuate to {beta}-carboxy-cis,cis-muconate.

  15. Progress in Understanding Degradation Mechanisms and Improving Stability in Organic Photovoltaics.

    PubMed

    Mateker, William R; McGehee, Michael D

    2017-03-01

    Understanding the degradation mechanisms of organic photovoltaics is particularly important, as they tend to degrade faster than their inorganic counterparts, such as silicon and cadmium telluride. An overview is provided here of the main degradation mechanisms that researchers have identified so far that cause extrinsic degradation from oxygen and water, intrinsic degradation in the dark, and photo-induced burn-in. In addition, it provides methods for researchers to identify these mechanisms in new materials and device structures to screen them more quickly for promising long-term performance. These general strategies will likely be helpful in other photovoltaic technologies that suffer from insufficient stability, such as perovskite solar cells. Finally, the most promising lifetime results are highlighted and recommendations to improve long-term performance are made. To prevent degradation from oxygen and water for sufficiently long time periods, OPVs will likely need to be encapsulated by barrier materials with lower permeation rates of oxygen and water than typical flexible substrate materials. To improve stability at operating temperatures, materials will likely require glass transition temperatures above 100 °C. Methods to prevent photo-induced burn-in are least understood, but recent research indicates that using pure materials with dense and ordered film morphologies can reduce the burn-in effect.

  16. [Research Progress in Technology of Using Soil Micro-organisms to Generate Electricity and Its Potential Applications].

    PubMed

    Deng, Huan; Xue, Hong-jing; Jiang, Yun-bin; Zhong, Wen-hui

    2015-10-01

    Microbial fuel cells ( microbial fuel cells, MFCs) are devices in which micro-organisms convert chemical energy into electrical power. Soil has electrogenic bacteria and organic substrates, thus can generate electrical current in MFCs. Soil MFCs can be operated and applied to real-time and continuously monitor soil pollution, remove soil pollutants and to reduce methane emitted from flooded rice paddy, without energy consumption and the application of chemical reagents to the soil. Instead, the operation of soil MFCs generates small amount of electrical power. Therefore, soil MFCs are useful in the development of environment-friendly technology for monitoring and remediating soil pollution, which have potential value for applications in the domain of environmental science and engineering. However, much of advanced technology hasn't been applied into soil MFCs since the studies on soil MFCs was not started until recently. This paper summarized the research progress in related to soil MFCs combining with the frontier of MFCs technology, and brought forward the possible direction in studies on soil MFCs.

  17. Building organizational supports for knowledge sharing in county human service organizations: a cross-case analysis of works-in-progress.

    PubMed

    Lee, Chris; Austin, Michael J

    2012-01-01

    Building on the literature related to evidence-based practice, knowledge management, and learning organizations, this cross-case analysis presents twelve works-in-progress in ten local public human service organizations seeking to develop their own knowledge sharing systems. The data for this cross-case analysis can be found in the various contributions to this Special Issue. The findings feature the developmental aspects of building a learning organization that include knowledge sharing systems featuring transparency, self-assessment, and dissemination and utilization. Implications for practice focus on the structure and processes involved in building knowledge sharing teams inside public human service organizations.

  18. Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis

    PubMed Central

    Yang, Shang-Wu; Gao, Chen; Chen, Lei; Song, Ya-Li; Zhu, Jin-Liang; Qi, Shu-Tao; Jiang, Zong-Zhe; Wang, Zhong-Wei; Lin, Fei; Huang, Hao; Xing, Fu-Qi; Sun, Qing-Yuan

    2012-01-01

    Nek9 (also known as Nercc1), a member of the NIMA (never in mitosis A) family of protein kinases, regulates spindle formation, chromosome alignment and segregation in mitosis. Here, we showed that Nek9 protein was expressed from germinal vesicle (GV) to metaphase II (MII) stages in mouse oocytes with no detectable changes. Confocal microscopy identified that Nek9 was localized to the spindle poles at the metaphase stages and associated with the midbody at anaphase or telophase stage in both meiotic oocytes and the first mitotic embyros. Depletion of Nek9 by specific morpholino injection resulted in severely defective spindles and misaligned chromosomes with significant pro-MI/MI arrest and failure of first polar body (PB1) extrusion. Knockdown of Nek9 also impaired the spindle-pole localization of γ-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores even after 10 h of culture. Live-cell imaging analysis also confirmed that knockdown of Nek9 resulted in oocyte arrest at the pro-MI/MI stage with abnormal spindles, misaligned chromosomes and failed polar body emission. Taken together, our results suggest that Nek9 may act as a MTOC-associated protein regulating microtubule nucleation, spindle organization and, thus, cell cycle progression during mouse oocyte meiotic maturation, fertilization and early embryo cleavage. PMID:23159858

  19. Progressive alterations in microstructural organization and biomechanical response in the ApoE mouse model of aneurysm

    PubMed Central

    Haskett, Darren; Azhar, Mohamad; Utzinger, Urs; Vande Geest, Jonathan P.

    2013-01-01

    AAA is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the ApoE−/− AngII mouse model of aneurysm during disease progression. Adult ApoE−/− AngII infused mice along with wild-type controls were taken at 14 and 28 d. Aortas were excised and tested simultaneously for biaxial mechanical response and ECM organization. Data sets were fit to a Fung-type constitutive model to give peak strains and stiffness values. Images from two photon microscopy were quantified in order to assess the preferred fiber alignment and degree of fiber orientation. Biomechanical results found significant differences that were present at 14 d had returned to normal by 28 d along with significant changes in fiber orientation and dispersion indicating remodeling occurring within the aneurysmal wall. This return of some of the normal biomechanical function, in addition the continuing changes that occur in the microstructure suggest a restorative response that occurs in the ApoE−/− AngII infused model after the initial aneurysm formation. PMID:23628871

  20. Department of Defense Program Solicitation 95; Small Business Technology Transfer (STTR) Program; FY 1995.

    DTIC Science & Technology

    1995-01-01

    remediation technologies such as in situ aerobic bioremediation . Knowledge gained through this research can be incorporated into a treatment process plan...Environics Directorate and the Occupational and Environmental Health Directorate. a. Innovative research is needed to develop a technique to image...3 2.1 Research or Research and Development ............................................ 2 2.2 Cooperative Research and Development

  1. FY 1991--FY 1995 Information Technology Resources Long-Range Plan

    SciTech Connect

    Not Available

    1989-12-01

    The Department of Energy has consolidated its plans for Information Systems, Computing Resources, and Telecommunications into a single document, the Information Technology Resources Long-Range Plan. The consolidation was done as a joint effort by the Office of ADP Management and the Office of Computer Services and Telecommunications Management under the Deputy Assistant Secretary for Administration, Information, and Facilities Management. This Plan is the product of a long-range planning process used to project both future information technology requirements and the resources necessary to meet those requirements. It encompasses the plans of the various organizational components within the Department and its management and operating contractors over the next 5 fiscal years, 1991 through 1995.

  2. Radiological control FY 1995 site support program plan WBS 6.7.2.4

    SciTech Connect

    Not Available

    1994-09-01

    The 1995 Site Support Program Plan (SSPP) brings year planning and execution year planning into a single document. The plan presented consists of the following four major sections: Overview and Introduction - Health physics has been renamed Radiological Control (RadCon) with the role of protecting workers, the public and the environment from the harmful effects of radiation resulting from the DOE Hanford Site Operations; Cost Baselines which contains cost, technical and schedule baselines; Execution Year work Plan - cost summaries and detailed descriptions of the work to be done; Appendix - including brief description of other project activities directly coupled to RadCon.

  3. External communication FY 1995 Site Support Program Plan WBS 6.10.6

    SciTech Connect

    Whiting, W.P.

    1994-09-01

    External Communications activities provide value to the company, its projects, and DOE by achieving compliance to more than 30 DOE orders, DOE directives, policies, state and federal laws. Through the systematic development of informed consent involving Hanford management, stakeholders, the general public and regulators, Hanford cleanup is better able to proceed in concert with involved parties. External Communications provides further efficiencies as the single point of contact for media interactions which otherwise would be scattered throughout WHC programs. Enhanced efficiency is expected from the realignment of multi-purpose communication teams which are dedicated to five key programmatic areas: TWRS Communications, Transition Facilities Communications, Spent Fuels Communications, Waste, Analytical and Environmental Services Communications, and Program Communications Services.

  4. Materials management FY 1995 site support program plan WBS 6.10.7

    SciTech Connect

    Dahlin, E.C.

    1994-09-01

    The Work Breakdown Structure is tabulated for the six main activities within the materials management site support program. Materials Management involves the receipt, storage, issuance, management and disposition of the government`s physical assets. Property Management involves maintaining acceptable levels of property accountability and proper utilization of government owned property. Warehousing involves the shipping, receiving, storage, issuance, and distribution of materials, parts, components and equipment required to support the ongoing operation of the Hanford Site. Inventory Management maintains appropriate levels of general supplies, spare parts, and essential materials to ensure availability of items required to support site operations is timely and provided at the lowest possible cost. Investment Recovery involves the identification and disposition of assets excess to the needs of the site through redeployment, recycling initiatives, and public sale of surplus property. Property Systems operate, maintain and enhance the development of cost effective data systems to control and administer multi-contractor personal property assets.

  5. Quality assurance FY 1995 site support program plan WBS 6.7.2.5

    SciTech Connect

    Dell, L.D.

    1994-09-01

    This report is a summary of the quality assurance plan and program for the Westinghouse Hanford Company. The quality assurance plan verifies that the appropriate quality assurance programs and controls are applied to activities that affect quality related to work in: waste management; environmental activities (restoration, remediation, and monitoring); implementation of environmental, state, local, and federal regulations; tri-party agreement activities; facility operation and deactivation/transition to shutdown; new facility construction and operation.

  6. Human resources FY 1995 Site Program Plan WBS 6.10.2

    SciTech Connect

    Not Available

    1994-09-01

    This document contains information concerning human resources management at the Hanford Reservation. Information discusses the following topics: Cost estimates, closure and placement of labor resources, and management of human resources throughout the Hanford Site.

  7. Department of the Navy. FY 1994/FY 1995 Biennial Budget Estimates. Military Construction Program. FY 1994

    DTIC Science & Technology

    1992-01-01

    APPROPRIATIONS . - (NON-ADD)( 6,400) p 10. DESCRIPTION OF PROPOSED CONSTRUCTION Two-story reinforced concrete and masonry building, pile foundation, brick... concrete and masonry addition on concrete slab, built-up roof. air conditioning. sound attenuation, raised computer flooring, utilities. fire protection...CONSTRUCTION Permanent-type construction. concrete foundation walls, footing and concrete floors, masonry walls; interior control room with special lighting

  8. FY 1995 Scientific and Technical Reports, Articles, Papers, and Presentations, Volume 1

    NASA Technical Reports Server (NTRS)

    Turner, Joyce E. (Compiler)

    1995-01-01

    This document presents formal NASA technical reports, papers published in technical journals, and presentations by MSFC personnel in FY95. It also includes papers of MSFC contractors. The information in this report may be of value to the scientific and engineering community in determining what information has been published and what is available.

  9. Small Change: Expenditures for Resources in School Library Media Centers, FY 1995-1996.

    ERIC Educational Resources Information Center

    Miller, Marilyn L.; Shontz, Marilyn L.

    1997-01-01

    Comparing 1994 and 1996, the eighth biennial survey of school libraries found median expenditures for books unchanged; audiovisuals, periodicals, microforms, and CD-ROM expenditures down; and software, local area network, and Internet expenditures up. The report also examines the extent of collaboration between library media specialists and…

  10. Pollution prevention opportunity assessment approach, training, and technical assistance for DOE contractors. FY 1995 report

    SciTech Connect

    Pemberton, S.

    1996-02-01

    The Department of Energy and its contractors are faced with environmental concerns and large waste management costs. Federal legislation and DOE Orders require sites to develop waste minimization/pollution prevention programs. In response to these requirements, the Kansas City Plant developed a pollution prevention tool called a pollution prevention opportunity assessment (PPOA). Pilot assessments resulted in the development of a graded approach to reduce the amount of effort required for activities that utilized nonhazardous and/or low-volume waste streams. The project`s objectives in FY95 were to validate DOE`s PPOA Graded Approach methodology, provide PPOA training and technical assistance to interested DOE personnel and DOE contractors, enhance the methodology with energy analysis and tools for environmental restoration activities, implement a DOE-wide PPOA database, and provide support to DOE EM-334 in the completion of a report which estimates the future potential for pollution prevention and waste minimization in the DOE complex.

  11. Emergency Medical Services for Children: Abstracts of Active Projects FY 1995.

    ERIC Educational Resources Information Center

    National Center for Education in Maternal and Child Health, Arlington, VA.

    This publication provides abstracts of 43 active and 34 completed projects designed to improve pediatric emergency care. The projects were funded by the United States Department of Health and Human Services' Maternal and Child Health Bureau, in collaboration with the United States Department of Transportation's National Highway Traffic Safety…

  12. Advanced Industrial Materials (AIM) Program: Compilation of project summaries and significant accomplishments, FY 1995

    SciTech Connect

    1996-04-01

    In many ways, the Advanced Industrial Materials (AIM) Program underwent a major transformation in Fiscal Year 1995 and these changes have continued to the present. When the Program was established in 1990 as the Advanced Industrial Concepts (AIC) Materials Program, the mission was to conduct applied research and development to bring materials and processing technologies from the knowledge derived from basic research to the maturity required for the end use sectors for commercialization. In 1995, the Office of Industrial Technologies (OIT) made radical changes in structure and procedures. All technology development was directed toward the seven ``Vision Industries`` that use about 80% of industrial energy and generated about 90% of industrial wastes. The mission of AIM has, therefore, changed to ``Support development and commercialization of new or improved materials to improve productivity, product quality, and energy efficiency in the major process industries.`` Though AIM remains essentially a National Laboratory Program, it is essential that each project have industrial partners, including suppliers to, and customers of, the seven industries. Now, well into FY 1996, the transition is nearly complete and the AIM Program remains reasonably healthy and productive, thanks to the superb investigators and Laboratory Program Managers. This report contains the technical details of some very remarkable work by the best materials scientists and engineers in the world. Subject areas covered are: advanced metals and composites; advanced ceramics and composites; polymers and biobased materials; and new materials and processes.

  13. Joint Logistics Systems Center Information Technology Budget FY 1995 Budget Estimates

    DTIC Science & Technology

    1994-01-01

    methods, communication backbone and standardized record formats, supporting Electronic Data Interchange, application of artificial intelligence ...standardized record formats, supporting Electronic Data Interchange, application of artificial intelligence technologies to tactical logistics planning...6.044 6,52 4,94 7,393 7,124 1-18cIP10 Cap hift Mgmt (COM Wholesale siuofaw I’m4 7,006 6,35 7.W5 6,006 6,102 30 wodlyoam 2 2 2 2 2 2 2 Detense Busines

  14. SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM ANNUAL REPORT TO CONGRESS FY 1995

    EPA Science Inventory

    The Superfund Innovative Technology Evaluation (SITE) Program was established more than nine years ago to encourage the development and implementation of innovative treatment technologies for hazardous waste site remediation. Development of this program was in direct response to ...

  15. Financial services FY 1995 site support program plan WBS 6.10.4

    SciTech Connect

    Vodney, E.P.

    1994-09-01

    This is the signed Financial Service fiscal year 1995 Site Support Program Plan, Work Breakdown Structure 6.10.4, for the Hanford site. This plan is intended to enable the contractor to accomplish the following: ensure financial integrity in all Westinghouse Hanford Company (WHC) operation while supporting the programmatic activities of WHC, the US Department of Energy, Richland Operations Office, and other Hanford contractors; provide efficient and effective financial services, and value added audits and review that enable management to enhance future operational results.

  16. General Counsel`s office FY 1995 site support program plan WBS 6.10.5

    SciTech Connect

    Moreno, S.R.

    1994-09-01

    The General Counsel`s office provides legal counsel to all levels of WHC management; administers the intellectual property program; coordinates all WHC investigative activity and supports WHC activities to ensure compliance with all applicable federal, state, and local laws, DOE directives, contractual provisions, and other requirements. In so doing, the Office of General Counsel supports the Hanford site mission of transforming the Hanford site into an environmentally attractive and economically sustainable community. This document briefs the FY95 site support plan.

  17. Department of the Air Force. FY 1995 Budget Estimates. Military Construction and Family Housing

    DTIC Science & Technology

    1994-02-01

    of 6-14 inch single wall fiberglass piping installed in 1972. This system has no provision for leak detection or spill containment as required by the...interior runway overruns with two inches of asphalt pavement. Construct asphalt shoulders with minimum of four inches of base material. Restripe...replace with double-walled fiberglass reinforced plastic tanks and upgrade five deep buried tanks to include replacing the product supply lines

  18. Capital Construction Funding Priorities, FY 1995-96. Presentation to the Legislative Capital Development Committee.

    ERIC Educational Resources Information Center

    Colorado Commission on Higher Education, Denver.

    The primary goal of the Capital Construction Program for Colorado public colleges and universities is to adopt an action schedule for legislative budgeting of funds to meet approved educational program needs, to provide facilities of comparable quality to serve the students at the 22 campuses, and to create a safe and healthful environment…

  19. Defense Information Systems Agency, FY 1995 Budget Estimates. Report on Information Technology.

    DTIC Science & Technology

    1994-02-01

    2,000 0 0 DFAS: Technical integration services 0 0 25 DMA: DPACS support 25 15 5 DMSA : Commercial training 176 129 136 Migration studies 50 25 25 Exhibit...SUMMARY REPORT ON OPERATIONS AND OTHER COST DMA: DPACS supm 25 15 5 DMSA : Commercial training 176 129 136 Mgration studies 50 25 25 DSS-W: Data admin

  20. Planning integration FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP)

    SciTech Connect

    Not Available

    1994-09-01

    This Multi-Year Program Plan (MYPP) for the Planning Integration Program, Work Breakdown structure (WBS) Element 1.8.2, is the primary management tool to document the technical, schedule, and cost baseline for work directed by the US Department of Energy (DOE), Richland Operations Office (RL). As an approved document, it establishes a binding agreement between RL and the performing contractors for the work to be performed. It was prepared by the Westinghouse Hanford Company (WHC) and the Pacific Northwest Laboratory (PNL). This MYPP provides a picture from fiscal year 1995 through FY 2001 for the Planning Integration Program. The MYPP provides a window of detailed information for the first three years. It also provides `execution year` work plans. The MYPP provides summary information for the next four years, documenting the same period as the Activity Data Sheets.

  1. Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

    PubMed Central

    Honarpisheh, Mohsen; Desai, Jyaysi; Marschner, Julian A.; Weidenbusch, Marc; Lech, Maciej; Vielhauer, Volker; Anders, Hans-Joachim; Mulay, Shrikant R.

    2016-01-01

    The species-specific, as well as organ-specific expression of regulated necrosis (RN)-related molecules, is not known. We determined the expression levels of tumour necrosis factor receptor-1 (TNFR1), receptor activated protein kinase (RIPK)1, RIPK3, mixed lineage kinase domain-like (MLKL), CASP8, Fas-associated protein with death domain (FADD), cellular inhibitor of apoptosis protein (CIAP)1, CIAP2, glutathione peroxidase-4 (GPX4), cyclophilin D (CYPD), CASP1, NLRP3 and poly(ADP-ribose) polymerase-1 (PARP1) in human and mouse solid organs. We observed significant differences in expression of these molecules between human and mice. In addition, we characterized their expression profiles in acute as well as persistent tissue injury and chronic tissue remodelling using acute and chronic kidney injury models. We observed that the degree and pattern of induction of RN-related molecules were highly dependent on the trigger and disease pathogenesis. Furthermore, we studied their expression patterns in mice with lupus-like systemic autoimmunity, which revealed that the expression of MLKL, GPX4 and PARP1 significantly increased in the spleen along disease progression and CASP1, RIPK1, RIPK3 and CYPD were higher at the earlier stages but were significantly decreased in the later stages. In contrast, in the kidney, the expression of genes involved in pyroptosis, e.g. NLRP3 and CASP1 were significantly increased and TNFR1, RIPK1, RIPK3, CIAP1/2 and GPX4 were significantly decreased along the progression of lupus nephritis (LN). Thus, the organ- and species-specific expression of RN-related molecules should be considered during designing experiments, interpreting the results as well as extrapolating the conclusions from one species or organ to another species or organ respectively. PMID:27811014

  2. Parallel comparison of risk factors between progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome by covariance structure analysis

    PubMed Central

    Ogawa, Kazuo; Minai, Kosuke; Kawai, Makoto; Tanaka, Toshikazu; Nagoshi, Tomohisa; Ogawa, Takayuki; Yoshimura, Michihiro

    2017-01-01

    Background It is widely accepted that progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome (ACS) are similar in the development of atherosclerosis. However, the extent of the association of each risk factor with the respective pathological conditions has not been fully elucidated. Objectives We investigated the differences in risk factors between these conditions using a statistical procedure. Methods The study population consisted of 1,029 patients with ischemic heart disease (IHD). We divided the study population into two groups (ACS and non-ACS) and by diseased vessels (organic stenosis). Covariance structure analysis was simultaneously performed in one equation model for determination and comparison of the risk factors for organic stenosis and ACS. Results The analysis revealed that age (standardized regression coefficient, β: 0.206, P < 0.001), male gender (β: 0.126, P < 0.001), HbA1c level (β: 0.109, P < 0.001), HDL level (β: -0.109, P < 0.001) and LDL level (β: 0.127, P = 0.002) were significant for the advancement of organic stenosis. HDL level (β: 0100, P = 0.002) and MDA-LDL level (β: 0.335, P < 0.001) were significant for the onset of ACS, but age, HbA1c and LDL (P = NS or β < 0.1, respectively) were not. Among the risk factors, age, HbA1c and LDL were significantly more strongly associated with organic stenosis than ACS, while MDA-LDL was significantly more strongly associated with ACS than organic stenosis. Conclusions The current statistical analysis revealed clear differences among the risk factors between the progression of organic stenosis and the onset of ACS. Among them, the MDA-LDL level should be considered to indicate a substantial risk of ACS. PMID:28301565

  3. Design and construction of deinococcus radiodurans for biodegradation of organic toxins at radioactive DOE waste sites. 1998 annual progress report

    SciTech Connect

    Daly, M.J.; Wackett, L.P.; Minton, K.W.

    1998-06-01

    'A 1992 survey of DOE waste sites indicates that about 32% of soils and 45% of groundwaters at these sites contain radionuclides and metals plus an organic toxin class. The most commonly reported combinations of these hazardous compounds being radionuclides and metals (e.g., U, Pu, Cs, Pb, Cr, As) plus chlorinated hydrocarbons (e.g., trichloroethylene), fuel hydrocarbons (e.g., toluene), or polychlorinated biphenyls (e.g., Arochlor 1248). These wastes are some of the most hazardous pollutants and pose an increasing risk to human health as they leach into the environment. The objective of this research is to develop novel organisms, that are highly resistant to radiation and the toxic effects of metals and radionuclides, for in-situ bioremediation of organic toxins. Few organisms exist that are able to remediate such environmental organic pollutants, and among those that can, the bacteria belonging to the genus Pseudomonas are the most characterized. Unfortunately, these bacteria are very radiation sensitive. For example, Pseudomonas spp. is even more sensitive than Escherichia coli and, thus, is not suitable as a bioremediation host in environments subjected to radiation. By contrast, D. radiodurans, a natural soil bacterium, is the most radiation resistant organism yet discovered; it is several thousand times more resistant to ionizing radiation than Pseudomonas. The sophisticated gene transfer and expression systems the authors have developed for D. radiodurans over the last eight years make this organism an ideal candidate for high-level expression of genes that degrade organic toxins, in radioactive environments. The authors ultimate aim is to develop organisms and approaches that will be useful for remediating the large variety of toxic organic compounds found in DOE waste sites that are too radioactive to support other bioremediation organisms. This report summarizes work after the first 6 months of a 3-year project.'

  4. Organics.

    ERIC Educational Resources Information Center

    Chian, Edward S. K.; DeWalle, Foppe B.

    1978-01-01

    Presents water analysis literature for 1978. This review is concerned with organics, and it covers: (1) detergents and surfactants; (2) aliphatic and aromatic hydrocarbons; (3) pesticides and chlorinated hydrocarbons; and (4) naturally occurring organics. A list of 208 references is also presented. (HM)

  5. Organizers.

    ERIC Educational Resources Information Center

    Callison, Daniel

    2000-01-01

    Focuses on "organizers," tools or techniques that provide identification and classification along with possible relationships or connections among ideas, concepts, and issues. Discusses David Ausubel's research and ideas concerning advance organizers; the implications of Ausubel's theory to curriculum and teaching; "webbing," a…

  6. The use of dielectric and NMR measurements to determine the pore-scale location of organic contaminants. 1997 annual progress report

    SciTech Connect

    Knight, R.; Bryar, T.; Caputi, M.

    1997-07-15

    'The objective of the three-year research project is to investigate the effect of adsorbed organics on the dielectric and nuclear magnetic resonance (NMR) response of porous geological materials. This will allow us to assess the use of dielectric and NMR measurements at a site to determine whether organic contaminants are present in the central volume of the pore space (in a water-wet system) or are adsorbed to the solid surface. In addition, the authors propose to use laboratory dielectric and NMR measurements to study the kinetics of the adsorption and desorption of organics by conducting experiments where the authors control temperature and vary fluid chemistry. This project can be divided into three parts: sample preparation, NMR studies, dielectric studies. Over the past nine months the authors have made significant progress in sample preparation and NMR studies. As the plan is to conduct the NMR and dielectric measurements on the same set of samples, the authors delayed the start of the dielectric measurements until the first stage of NMR measurements were complete. Below the authors summarize the progress in sample preparation and NMR measurements, first briefly introducing the method used for the NMR measurements.'

  7. Petroleum effects on neural systems in marine organisms. Progress report, 1 August 1979-14 April 1980

    SciTech Connect

    Not Available

    1980-01-01

    Progress is reported in the following areas: (1) petroleum effects on chemosensory systems in the kelp crab, Pugettia producta, and the California spiny lobster, Panulirus interruptus; (2) chemosensory bradycardia in the spiny lobster; (3) petroleum effects on epithelial potentials in the coelenterate Tubularia; (4) petroleum effects on bioluminescence in the marine dinoflagellate, Pyrocystis fusiformis; and (5) analysis of petroleum for neurological testing on crustacea. (ACR)

  8. Bacteria Contribute to Sediment Nutrient Release and Reflect Progressed Eutrophication-Driven Hypoxia in an Organic-Rich Continental Sea

    PubMed Central

    Sinkko, Hanna; Lukkari, Kaarina; Sihvonen, Leila M.; Sivonen, Kaarina; Leivuori, Mirja; Rantanen, Matias; Paulin, Lars; Lyra, Christina

    2013-01-01

    In the sedimental organic matter of eutrophic continental seas, such as the largest dead zone in the world, the Baltic Sea, bacteria may directly participate in nutrient release by mineralizing organic matter or indirectly by altering the sediment’s ability to retain nutrients. Here, we present a case study of a hypoxic sea, which receives riverine nutrient loading and in which microbe-mediated vicious cycles of nutrients prevail. We showed that bacterial communities changed along the horizontal loading and vertical mineralization gradients in the Gulf of Finland of the Baltic Sea, using multivariate statistics of terminal restriction fragments and sediment chemical, spatial and other properties of the sampling sites. The change was mainly explained by concentrations of organic carbon, nitrogen and phosphorus, which showed strong positive correlation with Flavobacteria, Sphingobacteria, Alphaproteobacteria and Gammaproteobacteria. These bacteria predominated in the most organic-rich coastal surface sediments overlain by oxic bottom water, whereas sulphate-reducing bacteria, particularly the genus Desulfobacula, prevailed in the reduced organic-rich surface sediments in the open sea. They correlated positively with organic nitrogen and phosphorus, as well as manganese oxides. These relationships suggest that the bacterial groups participated in the aerobic and anaerobic degradation of organic matter and contributed to nutrient cycling. The high abundance of sulphate reducers in the surficial sediment layers reflects the persistence of eutrophication-induced hypoxia causing ecosystem-level changes in the Baltic Sea. The sulphate reducers began to decrease below depths of 20 cm, where members of the family Anaerolineaceae (phylum Chloroflexi) increased, possibly taking part in terminal mineralization processes. Our study provides valuable information on how organic loading affects sediment bacterial community compositions, which consequently may maintain active

  9. Bacteria contribute to sediment nutrient release and reflect progressed eutrophication-driven hypoxia in an organic-rich continental sea.

    PubMed

    Sinkko, Hanna; Lukkari, Kaarina; Sihvonen, Leila M; Sivonen, Kaarina; Leivuori, Mirja; Rantanen, Matias; Paulin, Lars; Lyra, Christina

    2013-01-01

    In the sedimental organic matter of eutrophic continental seas, such as the largest dead zone in the world, the Baltic Sea, bacteria may directly participate in nutrient release by mineralizing organic matter or indirectly by altering the sediment's ability to retain nutrients. Here, we present a case study of a hypoxic sea, which receives riverine nutrient loading and in which microbe-mediated vicious cycles of nutrients prevail. We showed that bacterial communities changed along the horizontal loading and vertical mineralization gradients in the Gulf of Finland of the Baltic Sea, using multivariate statistics of terminal restriction fragments and sediment chemical, spatial and other properties of the sampling sites. The change was mainly explained by concentrations of organic carbon, nitrogen and phosphorus, which showed strong positive correlation with Flavobacteria, Sphingobacteria, Alphaproteobacteria and Gammaproteobacteria. These bacteria predominated in the most organic-rich coastal surface sediments overlain by oxic bottom water, whereas sulphate-reducing bacteria, particularly the genus Desulfobacula, prevailed in the reduced organic-rich surface sediments in the open sea. They correlated positively with organic nitrogen and phosphorus, as well as manganese oxides. These relationships suggest that the bacterial groups participated in the aerobic and anaerobic degradation of organic matter and contributed to nutrient cycling. The high abundance of sulphate reducers in the surficial sediment layers reflects the persistence of eutrophication-induced hypoxia causing ecosystem-level changes in the Baltic Sea. The sulphate reducers began to decrease below depths of 20 cm, where members of the family Anaerolineaceae (phylum Chloroflexi) increased, possibly taking part in terminal mineralization processes. Our study provides valuable information on how organic loading affects sediment bacterial community compositions, which consequently may maintain active

  10. A 200 year sedimentary record of progressive eutrophication in Lake Greifen (Switzerland): Implications for the origin of organic-carbon-rich sediments

    SciTech Connect

    Hollander, D.J. ); McKenzie, J.A. ); Haven, H.L. ten )

    1992-09-01

    Over the past 200 years Lake Greifen, a small lake in northeastern Switzerland, has undergone dramatic changes in primary productivity and eutrophication due to increased nutrient supply from agricultural activity and industrialization. A 40 year historical record of the water-column chemistry indicates that productivity and eutrophication reached a maximum in 1974, after which stricter regulations on the input of nutrients resulted in a progressive decrease. Collected cores show the sedimentary expression of this anthropogenically induced eutrophication by a well-developed annual sedimentation and by enhanced values of total organic carbon, organic-carbon accumulation rates, and hydrogen indices (HI) of the kerogens. Analyses of the carbon isotopic composition of sedimentary carbonates and organic matter reveal that the fractionation between these two phases varies with the HI of kerogens. This observation is explicable in terms of changing productivity and preservation of the organic matter, and the CO[sub 2 (aq)] budget of the water body. The authors propose that if high primary productivity were primarily responsible for the preservation and accumulation of organic matter, then a negative correlation will occur between [Delta][delta][sup 13]C[sub calcite-organic matter]([Delta][delta][sup 13]C[sub cal-om]) and HI values. In an environment with relatively low to moderate productivity but with bottom-water anoxia, a positive correlation will exist between [Delta][delta][sup 13]C[sub cal-om] and HI values. This study of Lake Greifen has implications for understanding paleoenvironmental controls on ancient organic-carbon-rich sediments.

  11. Interfacing supercritical fluid reaction apparatus with on-line liquid chromatography: monitoring the progress of a synthetic organic reaction performed in supercritical fluid solution.

    PubMed

    Ramsey, Edward D; Li, Ben; Guo, Wei; Liu, Jing Y

    2015-04-03

    An interface has been developed that connects a supercritical fluid reaction (SFR) vessel directly on-line to a liquid chromatograph. The combined SFR-LC system has enabled the progress of the esterification reaction between phenol and benzoyl chloride to synthesize phenyl benzoate in supercritical fluid carbon dioxide solution to be dynamically monitored. This was achieved by the periodic SFR-LC analysis of samples directly withdrawn from the esterification reaction mixture. Using the series of SFR-LC analysis results obtained for individual esterification reactions, the reaction progress profile for each esterification reaction was obtained by expressing the measured yield of phenyl benzoate as a function of reaction time. With reaction temperature fixed at 75°C, four sets (n=3) of SFR-LC reaction progress profiles were obtained at four different SFR pressures ranging from 13.79 to 27.58 MPa. The maximum SFR yield obtained for phenyl benzoate using a standard set of reactant concentrations was 85.2% (R.S.D. 4.2%) when the reaction was performed at 13.79 MPa for 90 min. In comparison, a phenyl benzoate yield of less than 0.3% was obtained using the same standard reactant concentrations after 90 min reaction time at 75°C using either: heptane, ethyl acetate or acetonitrile as conventional organic reaction solvents.

  12. Rapid Progressive Seeding of a Community Acquired Pathogen in an Immune-Competent Host: End Organ Damage from Head to Bone

    PubMed Central

    Torres-Miranda, Daisy; Al-Saffar, Farah; Ibrahim, Saif; Diaz-Font, Stephanie

    2015-01-01

    Methicillin-sensitive Staphylococcus aureus (MSSA) meningitis is a rare disease when not related to neurosurgery: there are only few reported cases in the literature to date. We describe a case that highlights not only meningeal but also diffuse and rapidly progressive systemic involvement with multi-organ failure. A 64-year-old male presented to our hospital with a chief complaint of acute worsening of his usual chronic lower back pain, progressive weakness in lower extremities and subjective fevers at home. Hospital course demonstrated MSSA bacteremia, of questionable source, that resulted in endocarditis affecting right and left heart in a patient with no history of intravenous drug use. The case was complicated by septic emboli to systemic circulation involving the kidneys, vertebral spine, lungs and brain with consequent meningitis and stroke, even when treated empirically with vancomycin and then switched to nafcillin as indicated. Even though MSSA infections are well known, there are very few case reports describing such an acute-simultaneous-manifestation of multi-end-organ failure, including meningitis and stroke. Our case, also presented with an uncommon manifestation of persistent infection dissemination despite adequate antibiotic treatment. PMID:26294951

  13. Organization of the R chromosome region in maize: Final progress report, June 1, 1983--May 31, 1986

    SciTech Connect

    Kermicle, J.

    1989-02-01

    For the present study, insertional mutagenesis using transposable sequences proved the most effective means of producing /und R/ variants for fine structure study. Considerable effort was directed toward developing this means of mutagenesis. It was also necessary to describe the pattern of recombination that prevailed in this region when insertions were present. Thus some of the topics considered as separate items in the following discussion concern transposable element behavior and recombination as such. Until recently, genetic analysis had been the principal means of investigating /und R/ structure and function. With the advent of molecular cloning of maize genes by transposon tagging, a more direct means of investigating /und R/ structure was envisioned. This possibility was realized. We are now collaborating with these investigators to integrate genetic and molecular sources of evidence. This document summarizes publications of research sponsored by this grant, and recent findings that appear to be major advances but concerning which further experiments are in progress. 12 refs.

  14. Ion kinetics and thermochemistry pertinent to mass spectrometric organic speciation. Progress report, November 15, 1992--14 November 1995

    SciTech Connect

    Sieck, L.W.

    1998-05-01

    Essentially all of the completed/in progress studies during the last contract period have involved the NIST HPMS unit. Three distinct areas of in-house research are recognizable: (i) determinations of binding energies and entropies for association and cluster ions, which is accomplished by measuring the temperature dependence of the appropriate equilibrium, (ii) measurement of the temperature dependence unimolecular and bimolecular rate constants, and (iii) evaluation of PA`s, HA`s, and IP`s via measurement of variable-temperature equilibria of the type AH{sup +} + B {leftrightarrow} BH{sup +} + A, A{sup -} + BH {leftrightarrow} AH + B{sup -}, and A{sup +} + B {leftrightarrow} B+ + A. Key results from some representative projects are summarized below.

  15. The use of dielectric and NMR measurements to determine the pore-scale location of organic. 1998 annual progress report

    SciTech Connect

    Knight, R.

    1998-06-01

    'The objective of the three-year research project is to investigate the effect of adsorbed organics on the dielectric and nuclear magnetic resonance (NMR) response of porous geological materials. This will allow the author to assess the use of dielectric and NMR measurements at a site to determine whether organic contaminants are present in the central volume of the pore space or are adsorbed to the solid surfaces. In addition, she proposes to use laboratory dielectric and NMR measurements to study the kinetics of the adsorption and desorption of organics. This report summarizes work completed after 20 months of a three-year project. The research involves the study of the NMR and dielectric behavior of sands with three types of solid surfaces: water-wet, where water spontaneously coats and adsorbs to the solid surfaces; hydrophobic, where water is repelled from the solid surfaces by an organosilane coating; and oil-wet, where oil coats the solid surfaces. The oil-wet case is representative of a contaminated soil, in which oil has become adsorbed to the solid surfaces.'

  16. Noninvasive near-infrared fluorescent protein-based imaging of tumor progression and metastases in deep organs and intraosseous tissues

    NASA Astrophysics Data System (ADS)

    Jiguet-Jiglaire, Carine; Cayol, Mylène; Mathieu, Sylvie; Jeanneau, Charlotte; Bouvier-Labit, Corinne; Ouafik, L.'houcine; El-Battari, Assou

    2014-01-01

    Whole-body imaging of experimental tumor growth is more feasible within the near-infrared (NIR) optical window because of the highest transparency of mammalian tissues within this wavelength spectrum, mainly due to improved tissue penetration and lower autofluorescence. We took advantage from the recently cloned infrared fluorescent protein (iRFP) together with a human immunodeficiency virus (HIV)-based lentiviral vector to produce virally transduced tumor cells that permanently express this protein. We then noninvasively explored metastatic spread as well as primary tumor growth in deep organs and behind bone barriers. Intrabone tumor growth was investigated through intracranial and intratibial injections of glioblastoma and osteosarcoma cells, respectively, and metastasis was assessed by tail vein injection of melanoma cells. We found that the emitted fluorescence is captured as sharp images regardless of the organ or tissue considered. Furthermore, by overlaying fluorescence spots with the white light, it was possible to afford whole-body images yet never observed before. This approach allowed us to continuously monitor the growth and dissemination of tumor cells with a small number of animals, minimal animal handling, and without the need for any additive. This iRFP-based system provides high-resolution readouts of tumorigenesis that should greatly facilitate preclinical trials with anticancer therapeutic molecules.

  17. VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells.

    PubMed

    Ringer, Lymor; Sirajuddin, Paul; Heckler, Mary; Ghosh, Anup; Suprynowicz, Frank; Yenugonda, Venkata M; Brown, Milton L; Toretsky, Jeffrey A; Uren, Aykut; Lee, YiChien; MacDonald, Tobey J; Rodriguez, Olga; Glazer, Robert I; Schlegel, Richard; Albanese, Chris

    2011-11-01

    Medulloblastoma is the most prevalent of childhood brain malignancies, constituting 25% of childhood brain tumors. Craniospinal radiotherapy is a standard of care, followed by a 12mo regimen of multi-agent chemotherapy. For children less than 3 y of age, irradiation is avoided due to its destructive effects on the developing nervous system. Long-term prognosis is worst for these youngest children and more effective treatment strategies with a better therapeutic index are needed. VMY-1-103, a novel dansylated analog of purvalanol B, was previously shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. In the current study, we have identified new mechanisms of action by which VMY-1-103 affected cellular proliferation in medulloblastoma cells. VMY-1-103, but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death Receptors DR4 and DR5, Bax and Bad while decreasing the number of viable cells, all supporting apoptosis as a mechanism of cell death. p21(CIP1/WAF1) levels were greatly suppressed. Importantly, we found that while both VMY and flavopiridol inhibited intracellular CDK1 catalytic activity, VMY-1-103 was unique in its ability to severely disrupt the mitotic spindle apparatus significantly delaying metaphase and disrupting mitosis. Our data suggest that VMY-1-103 possesses unique antiproliferative capabilities and that this compound may form the basis of a new candidate drug to treat medulloblastoma.

  18. Organic geochemistry of continental margin and deep ocean sediments. Progress report, 1 March 1991--28 February 1993

    SciTech Connect

    Whelan, J.K.; Hunt, J.M.; Seewald, J.M.; Eglinton, L.B.; Zawoysky, M.; Dickinson, P.; Dickneider, T.

    1992-09-01

    Objective was to study petroleum formation, migration, and accumulation in marine sediments. Collaboration in Global Basin Research Network (GBRN) showed that the hydrocarbon parameters used in oil exploration are also valuable in understanding sedimentary basin fluid flow processes, crucial to production of drinking water, metal ore deposits, and gas and oil. Two goals are : (1) to run hydrous pyrolysis experiments on immature gas-prone source rocks, in order to evaluate the potential influence of gas evolution on oil migration and subsurface pressurization, and (2) to integrate organic geochemical data from the Louisiana Gulf Coast into GBRN subsurface visualization and computer modeling. Experimental methods (petrography, EPR, thermogravimetric Fourier transform infrared spectroscopy) were also studied.

  19. Regulation and genetic organization of hydrogenase: Final progress report for the period June 1, 1985--July 31, 1988

    SciTech Connect

    Krasna, A.I.

    1988-10-01

    Hydrogenase is an enzyme which plays an important role in the anaerobic metabolism of many bacteria. The objectives of the research were to elucidate the regulation and genetic organization of hydrogenase in microorganisms. A mutation in the E. coli hydE gene leads to loss of all hydrogenase activities and isoenzymes as well as all formate-related activities. A 0.9 kb DNA fragment has been cloned from an E. coli genomic DNA library which restored all hydrogenase and formate activities to a hydE mutant strain. This gene coded for a polypeptide of subunit mw 36 kDa which is required for hydrogenase synthesis. It is involved in incorporation of nickel into hydrogenase. A mutation in the E coli hupB gene leads to the loss of the uptake of H/sub 2/ by dyes and the ability to grow on fumarate plus H/sub 2/, but expresses normal levels of hydrogenase when assayed by deuterium exchange. This mutation also leads to loss of all formate-related activities. The mutation mapped near minute 17 and a single mutation was responsible for loss of both activities. A 1.4 kb DNA fragment was isolated which restored the hydrogen uptake activities and coded for a polypeptide of subunit mw 30 kDa. Dna fragments have been isolated from Chromatium vinosum and Proteus vulgaris which restored hydrogenase activities to E. coli strains with mutations in the hydA or hydB regulatory genes and which lack all hydrogenase activities. 6 refs., 12 figs.

  20. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension.

    PubMed

    Holditch, Sara J; Schreiber, Claire A; Nini, Ryan; Tonne, Jason M; Peng, Kah-Whye; Geurts, Aron; Jacob, Howard J; Burnett, John C; Cataliotti, Alessandro; Ikeda, Yasuhiro

    2015-07-01

    Altered myocardial structure and function, secondary to chronically elevated blood pressure, are leading causes of heart failure and death. B-type natriuretic peptide (BNP), a guanylyl cyclase A agonist, is a cardiac hormone integral to cardiovascular regulation. Studies have demonstrated a causal relationship between reduced production or impaired BNP release and the development of human hypertension. However, the consequences of BNP insufficiency on blood pressure and hypertension-associated complications remain poorly understood. Therefore, the goal of this study was to create and characterize a novel model of BNP deficiency to investigate the effects of BNP absence on cardiac and renal structure, function, and survival. Genetic BNP deletion was generated in Dahl salt-sensitive rats. Compared with age-matched controls, BNP knockout rats demonstrated adult-onset hypertension. Increased left ventricular mass with hypertrophy and substantially augmented hypertrophy signaling pathway genes, developed in young adult knockout rats, which preceded hypertension. Prolonged hypertension led to increased cardiac stiffness, cardiac fibrosis, and thrombi formation. Significant elongation of the QT interval was detected at 9 months in knockout rats. Progressive nephropathy was also noted with proteinuria, fibrosis, and glomerular alterations in BNP knockout rats. End-organ damage contributed to a significant decline in overall survival. Systemic BNP overexpression reversed the phenotype of genetic BNP deletion. Our results demonstrate the critical role of BNP defect in the development of systemic hypertension and associated end-organ damage in adulthood.

  1. Comparison or organic and inorganic ion exchange materials for removal of cesium and strontium from Hanford waste

    SciTech Connect

    Brown, G.N.; Carson, K.J.; DesChane, J.R.; Elovich, R.J.

    1997-10-01

    This work is part of an ESP-CP task to develop and evaluate high-capacity, selective, solid extractants for the uptake of cesium, strontium, and technetium (Cs, Sr, and Tc) from nuclear wastes. Pacific Northwest National Laboratory (PNNL) staff, in collaboration with researchers from industry, academia, and national laboratories are investigating these and other novel and commercial ion exchangers for use in nuclear waste remediation of groundwater, HLW, and LLW. Since FY 1995, experimental work at PNNL has focused on small-scale batch distribution (K{sub d}) testing of numerous solid sorbents with actual and simulated Hanford wastes, chemical and radiolytic stability of various organic ion exchanger resins, bench-scale column ion exchange testing in actual and simulated Complexant Concentrate (CC) and Neutralized Current Acid Waste (NCAW), and Tc and Sr removal from groundwater and LLW. In addition, PNNL has continued to support various site demonstrations at the Idaho National Engineering Laboratory, Savannah River Site, West Valley Nuclear Services, Hanford N-Springs, and Hanford N-Basin using technologies developed by their industrial partners. This summary will focus on batch distribution results from the actual waste tests. The data collected in these development and testing tasks provide a rational basis for the selection and direct comparison of various ion exchange materials in simulated and actual HLW, LLW, and groundwater. In addition, prediction of large-scale column loading performance for the materials tested is possible using smaller volumes of actual waste solution. The method maximizes information while minimizing experimental expense, time, and laboratory and process wastes.

  2. Department of Defense, Department of the Navy FY 1995 Budget Estimates Submission Report on Information Technology Systems

    DTIC Science & Technology

    1994-02-01

    awarded in 1984 to Martin Marietta Data System. A one-year extension to this contract has been approved, with the option of an additional year, if needed...DescriDtion: This program brings various Regional Administrative Service Center ( RASC ) and USMC base-level information technology infrastructure...remaining enhancements currently available with the Increment I software. B. Contracts: Martin Marietta, Information Systems Group is the systems

  3. FY 1995 Remedial Investigation Work Plan for Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

    SciTech Connect

    Watkins, D.R.; Herbes, S.E.

    1994-12-01

    The purpose of this project is to provide key information needed by decision makers to expedite the process of environmental restoration and to provide the data base required by the Remedial Investigation/Feasibility Study (RI/FS) for Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL). WAG 2 is the major drainage system downgradient of other WAGs that contain significant sources of contamination at ORNL. Field activities to support the remedial investigation for the RI portion include characterization of the nature and extent of contamination in WAG 2 [consisting of White Oak Creek (WOC) and associated tributaries and floodplain, White Oak Lake (WOL), and White Oak Creek Embayment (WOCE)], specifically to support risk-based remediation decisions. The project consists of three phases: Phase 1, initial scoping characterization to determine the need for early action; Phase 2, interim activities during remediation of upslope WAGs to evaluate potential changes in the contamination status of WAG 2 that would necessitate revaluation of the need for early action; and Phase 3, completion of the RI process following remediation of upslope WAGs. Overall RI objectives, consistent with ORNL Environmental Restoration (ER) Program strategic objectives to reduce risks and comply with environmental regulations, are discussed in the WAG 2 Remedial Investigation Plan.

  4. Isotope production and distribution Programs Fiscal Year (FY) 1995 Financial Statement Audit (ER-FC-96-01)

    SciTech Connect

    1996-02-12

    The charter of the Department of Energy (DOE) Isotope Production and Distribution Program (Isotope Program) covers the production and sale of radioactive and stable isotopes, associated byproducts, surplus materials such as lithium and deuterium, and related isotope services. Services provided include, but are not limited to, irradiation services, target preparation and processing, source encapsulation and other special preparations, analyses, chemical separations, and leasing of stable isotopes for research purposes. Isotope Program products and services are sold worldwide for use in a wide variety of research, development, biomedical, and industrial applications. The Isotope Program reports to the Director of the Office of Nuclear Energy, Science and Technology. The Isotope Program operates under a revolving fund, as established by the Fiscal Year 1990 Energy and Water Appropriations Act (Public Law 101-101). The Fiscal Year 1995 Appropriations Act (Public Law 103-316) modified predecessor acts to allow prices charged for Isotope Program products and services to be based on production costs, market value, the needs of the research community, and other factors. Prices set for small-volume, high-cost isotopes that are needed for research may not achieve full-cost recovery. Isotope Program costs are financed by revenues from the sale of isotopes and associated services and through payments from the isotope support decision unit, which was established in the DOE fiscal year 1995 Energy, Supply, Research, and Development appropriation. The isotope decision unit finances the production and processing of unprofitable isotopes that are vital to the national interest.

  5. Visual display of reservoir parameters affecting enhanced oil recovery. Quarterly report, April 1995--June 1995. 2nd Quarter, FY 1995

    SciTech Connect

    Wood, J.R.

    1995-04-05

    This report describes the development of a Spatial Database Manager (SDBM) shell/interface which will provide information to users on how to collect, store, analyze, interpret, visualize and present data in an integrated reservoir characterization study. SDBM will provide access to various geologic, reservoir visual data via a well log interpretation program (Crocker Petrolog), mapping and cross section software ( the GeoGraphix Exploration System Workbench) and a volume visualization application. Data tables for geochemical and petrographic data, well logs, well header information, well production data, formation tops, and fault trace data have been completed. Spectral mineral data are currently being collected which will ultimately be used for identification of mineral assemblages. The geochemical program CHILLER is being used to model fluid-rock interactions and possibly porosity predictions.

  6. Development and application of photosensitive device systems to studies of biological and organic materials. Third year progress report, January 1, 1992--December 31, 1992

    SciTech Connect

    Gruner, S.M.; Reynolds, G.T.

    1992-05-15

    This report describes progress as of the third year of a 3-year DoE grant for 1/1/92 to 12/31/92. Because this is the last year of a 3- year grant cycle, this report will summarize progress over the entire 3-year period. The overall goals of the grant are to develop novel instrumentation and techniques for the performance of biological and materials research, and especially for the development of x-ray detectors suitable for use at storage ring sources. Research progress has been excellent and the overall goals, as well as most of the specific goals have been successfully met.

  7. Scanning electron microscopic analyses of Ferrocyanide tank wastes for the Ferrocyanide safety program

    SciTech Connect

    Callaway, W.S.

    1995-09-01

    This is Fiscal Year 1995 Annual Report on the progress of activities relating to the application of scanning electron microscopy in addressing the Ferrocyanide Safety Issue associated with Hanford Site high-level radioactive waste tanks. The status of the FY 1995 activities directed towards establishing facilities capable of providing SEM based micro-characterization of ferrocyanide tank wastes is described. A summary of key events in the SEM task over FY 1995 and target activities in FY 1996 are presented. A brief overview of the potential applications of computer controlled SEM analytical data in light of analyses of ferrocyanide simulants performed by an independent contractor is also presented

  8. Oak Ridge Reservation Federal Facility Agreement. Quarterly report for the Environmental Restoration Program. Volume 4, July 1995--September 1995

    SciTech Connect

    1995-10-01

    This quarterly progress report satisfies requirements for the Environmental Restoration (ER) Program that are specified in the Oak Ridge Reservation Federal Facility Agreement (FFA) established between the U.S. Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA), and the Tennessee Department of Environment and Conservation (TDEC). The reporting period covered herein is July through September 1995 (fourth quarter of FY 1995). Sections 1.1 and 1.2 provide respectively the milestones scheduled for completion during the reporting period and a list of documents that have been proposed for transmittal during the following quarter but have not been approved as FY 1995 commitments.

  9. AGS experiments: 1993 - 1994 - 1995

    SciTech Connect

    Depken, J.C.

    1996-04-01

    This report contains: FY 1995 AGS Schedule as Run; FY 1996-97 AGE Schedule (working copy); AGS Beams 1995; AGS Experimental Area FY 1993 Physics Program; AGS Experimental Area FY 1994 Physics Program; AGS Experimental Area FY 1995 Physics Program; AGS Experimental Area FY 1996 Physics Program (In progress); A listing of experiments by number; Two-page summaries of each experiment begin here, also ordered by number; Listing of publications of AGS experiments begins here; and Listing of AGS experimenters begins here. This is the twelfth edition.

  10. DEVELOPING AN EXPOSURE-DOSE-RESPONSE MODEL FOR THE ACUTE NEUROTOXICITY OF ORGANIC SOLVENTS: OVERVIEW AND PROGRESS ON IN VITRO MODELS AND DOSIMETRY.

    EPA Science Inventory

    This article provides an overview of the current status of an exposure-dose-response (EDR) model for the volatile organic compound toluene. This model is being developed as a vehicle for understanding the neurotoxicity of organic solvents and will be used to support risk assessme...

  11. Dissolved organic matter and lake metabolism: Biogeochemistry and controls of nutrient flux dynamics to fresh waters. Technical progress report, January 1, 1990--December 31, 1991

    SciTech Connect

    Wetzel, R.G.

    1992-12-31

    The land-water interface region consists of two major components: the wetland, and the down-gradient adjacent littoral floating-leaved and submersed, macrophyte communities. Because of the importance of very high production and nutrient turnover of attached microbiota, a major emphasis of this investigation was placed upon these biota and their metabolic capacities for assimilation and release of organic compounds and nutrient retention and cycling. Examination of the capacities of wetland littoral communities to regulate fluxes of nutrients and organic compounds often has been limited to input-output analyses. These input-output data are an integral part of these investigations, but most of the research effort concentrated on the biotic and metabolic mechanisms that control fluxes and retention capacities and their effects upon biota in the down-gradient waters. The important regulatory capacities of dissolved organic compounds on enzyme reactivity was examined experimentally and coupled to the wetland-littoral organic carbon flux budgets.

  12. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site characterization study. Progress report, January 1, 1995--March 31, 1995

    SciTech Connect

    Stetzenbach, K.; Farnham, I.

    1995-05-01

    Fluorinated organic acids were utilized in a test study as hydrologic tracers for the Yucca Mountain Project. Fluorinated acids included cinnamic acid; benzoic acid, and toluic acid. Results are discussed pertaining to retention time, elution time, and stability.

  13. Burial, remineralization and utilization of organic matter at the seafloor under a strong western boundary current. Annual progress report, 1 May 1993--30 April 1994

    SciTech Connect

    Jahnke, R.A.

    1993-12-30

    The overall objectives of this project are to quantify the rates of organic carbon export from the southern mid-Atlantic Bight and to quantify the rates at which carbon is exchanged between the inorganic and organic pools within the bottom sediments. The strategy for achieving these goals is to quantify the rates of benthic exchange and burial of bioactive elements including oxidants (such as oxygen, nitrate, sulfate), micronutrient, and carbon system parameters on the continental shelf, slope and rise regions within and adjacent to the south portion of the mid-Atlantic Bight. This information, in conjunction with burial rates provided by others in this program, will be used to determine the locations and rates of export and oxidative loss of organic matter from the shelf. During this past funding period, three expeditions were completed to the study region, successfully conducting 6 in situ benthic flux chamber experiments. The results provide an initial assessment of the magnitude and location of organic matter export from the southern Middle Atlantic Bight shelf and of the importance of this region as a supplier of organic carbon to the North Atlantic Ocean Basin.

  14. Analysis of populations of boring and fouling organisms in the vicinity of the Oyster Creek Nuclear Generating Station. Quarterly progress report No. 12, Jun-Aug 79

    SciTech Connect

    Hoagland, K.E.; Crocket, L.

    1980-07-01

    The growth, distribution, and species composition of marine borers (primarily shipworms) and fouling organisms are being studied in the vicinity of the Oyster Creek Nuclear Generating Station, Barnegat Bay, New Jersey. Untreated wood test panels are used to collect organisms at 18 localities. Our most recent findings covering June-August, 1979, are that at least one subtropical species of the borer family Teredinidae, Teredo bartschi, continues to live in Oyster Creek and can breed in Forked River, although many die off in winter in Forked River and the species may have to recolonize. A few of the subtropical T. furcifera also survive in Oyster Creek but cause negligible damage at present, compared with T. bartschi. The summer, 1979, outbreak of T. bartschi in Oyster Creek was severe, causing nearly total destruction to wood panels. The breeding season for T. bartschi was the same as in 1978. Some fouling organisms were present in Oyster Creek that are absent in control creek stations due to low salinity.

  15. Production and turnover of suspended organic detritus in the coastal water of the southeastern continental shelf: Progress report, June 1, 1987-May 31, 1988

    SciTech Connect

    Pomeroy, L.R.

    1987-12-01

    This project describes specific aspects of microbial processes and related phenomena that influence the fate of particulate organic materials naturally produced on the continental shelf. SPREX is a cooperative study of the spring removal of water from the southeastern continental shelf. Our contribution included studies of respiratory rate of microorganisms, measurement of bacterial biomass and bacterial biomass production and measurement of carbon and nitrogen content of total seston. BIOTRANS is a cooperative study of the cycle of nitrogen and the flux of energy in the coastal water of the Georgia bight. We are measuring bacterial numbers and biomass production and bacterial respiration in the coastal water. Our studies provide us with an estimate of the rate of turnover of organic matter produced on the inner continental shelf. Marked differences occurred in the efficiency of bacterial utilization of dissolved organic matter between the coastal water and the more oceanic water of the middle and outer continental shelf. FLEX is a cooperative study of the removal of coastal water from the shelf as a result of the change from the summer to the fall wind regime in the southeast. We observed movement of water off the shelf north of Cape Canaveral and various biological consequences of this water movement. Our specific tasks included the measurement of microbial respiratory rates and tracing coastal water by means of dissolved lignins. The latter, which are of exclusively terrestrial origin, not only serve as a tracer tag on coastal water but also provide clues to the length of time the water has been in the coastal zone through changes in composition resulting from differential utilization by microorganisms of various components of the lignin molecules. Humates and fulvates were extracted at sea by chromatography. 60 refs., 12 figs., 7 tabs.

  16. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site Characterization Study; Progress report, July 1, 1991--December 31, 1991

    SciTech Connect

    Dombrowski, T.; Stetzenbach, K.

    1991-12-31

    Studies continued on organic tracers for use as hydrologic tracers as part of the Yucca Mountain Site Characterization project. Tracers studied include benzoic acids, cinnamic acids, and salicylic acids. The main focus of the work performed during the time period from 07/01/91 to 12/31/91 has been the continuation of (1) LC-MS optimization for tracer identification, (2) batch sorption and degradation studies, (3) neoprene tubing evaluation studies, and (4) soil column evaluation of tracer compounds. All of these areas of research (except perhaps the neoprene tubing evaluation) are ongoing and will continue throughout the coming year.

  17. 1. Progress toward the synthesis of vancosamine using a tandem [4+2]/[3+2] cycloaddition. 2. Discussion boards and pre-lecture quizzes in organic chemistry courses

    NASA Astrophysics Data System (ADS)

    Miller, Tyson A.

    The sugar vancosamine is one of the two sugar residues found on the broad spectrum antibiotic vancomycin. A strategy using a tandem intermolecular [4+2]/intermolecular [3+2] cycloaddition with nitro olefins was employed in an effort to enantioselectively synthesize the target. The [4+2] cycloaddition proceeded well with tin tetrachloride in high yield. However, the products from the [3+2] cycloaddition afforded diastereomers with stereocenters that were inconsistent with the natural product. An online facilitated group work assignment was introduced to a first semester non-majors organic chemistry lecture courses with large enrollments (˜300--660 students). Student opinion surveys, performance scores, and a detailed account of time spent by the facilitator afforded insight on the value of such assignments with large class sizes. Format and number of attempts were varied in online pre-lecture quizzes administered to a first semester non-majors organic chemistry lecture course. Student quiz performance and post-quiz assessment shows significant differences in mastery of material and class preparedness with format and number of attempts. When combined with student survey data, recommendations are made as to how format selection and number of attempts can optimize the value of online pre-lecture quizzes as a learning tool and as an assessment tool.

  18. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain site characterization study. Progress report, October 1, 1994--December 31, 1994

    SciTech Connect

    Stetzenbach, K.; Farnham, I.

    1994-12-31

    The bromide anion has been used extensively as a tracer for mapping the flow of groundwater. It has proven to be both a safe and reliable groundwater tracer. The goal in this study is to find several tracing compounds with characteristics similar to the bromide anion to be used in multiple well tracing tests. Four groups of fluorinated organic acids were selected as candidates for groundwater tracers. These groups include fluorinated benzoic acids (FBA), fluorinated salicylic acids (FSA), fluorinated toluic acids (FTA), and fluorinated cinnamic acids (FCA). These compounds have been shown to move readily with the flow of water and do not adsorb to soil. They are also non-toxic. In this study, the retention of the fluorinated organic acids on to a soil column is compared to that of the bromide ion. The time required for the elution of each analyte from the soil column is measured using a UV-Vis detector. The soils consist of the light, medium, and dark tuffs used in the batch study. The work performed during this quarter consists of the continuation of the batch studies for the fluorinated benzoic acids and column studies for several potential tracer compounds.

  19. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain Site Characterization Study; Progress report, June 1--December 31, 1990

    SciTech Connect

    Stetzenbach, K.J.

    1990-12-31

    Ground water tracers are solutes dissolved in or carried by ground water to delineate flow pathways. Tracers provide information on direction and speed of water movement and that of contaminants that might be conveyed by the water. Tracers can also be used to measure effective porosity, hydraulic conductivity, dispersivity and solute distribution coefficients. For most applications tracers should be conservative, that is, move at the same rate as the water and not sorb to aquifer materials. Tracers must have a number of properties to be functional. Regardless of the desired properties, the chemical and physical behavior of a tracer in ground water and the porous medium under study must be understood. Good estimates of tracer behavior can be obtained from laboratory studies. Studies in this proposal will address tracer properties with analytical method development, static sorption and degradation studies and column transport studies, Mutagenicity tests will be performed on promising candidates. The tracers that will be used for these experiments are fluorinated organic acids and other organic compounds that have the chemical and biological stability necessary to be effective in the Yucca Mountain environment. Special emphasis will be placed on compounds that fluoresce or have very large ultraviolet absorption coefficients for very high analytical sensitivity.

  20. The influence of interfacial properties on two-phase liquid flow of organic contaminants in groundwater. Progress report, September 1, 1993--August 31, 1994

    SciTech Connect

    Demond, A.H.; Hayes, K.F.

    1994-04-01

    Wettability is sometimes described as the most important factor influencing two-phase flow in porous media. A groundwater aquifer is often thought of as water-wet. But that state, in reality, depends on the nature of the aquifer solids, the composition of the groundwater and the properties of the organic liquid contaminant. The primary purpose of the research conducted here is to examine quantitatively the impact on wettability of a range of factors which may be critical at actual DOE waste sites. The goal is to understand how sorption at the various interfaces of the system modifies interfacial properties, primarily wettability, and then how, in turn, wettability determines the soil transport property of capillary pressure as a function of saturation. Specifically, this research seeks to (1) determine the range of wettability changes that may occur for DOE waste sites using wettability measures suitable for complex systems, (2) establish a correlation between these alternate measures of wettability and the contact angle, (3) establish the mechanism by which metals, organic solutes and soil particle coatings impact wettability, (4) evaluate whether the methodology developed in previous project periods among sorption, contact angle, and capillary pressure can be extended to more complex systems.

  1. Empirical estimates to reduce modeling uncertainties of soil organic carbon in permafrost regions: a review of recent progress and remaining challenges

    USGS Publications Warehouse

    Mishra, U.; Jastrow, J.D.; Matamala, R.; Hugelius, G.; Koven, C.D.; Harden, J.W.; Ping, S.L.; Michaelson, G.J.; Fan, Z.; Miller, R.M.; McGuire, A.D.; Tarnocai, C.; Kuhry, P.; Riley, W.J.; Schaefer, K.; Schuur, E.A.G.; Jorgenson, M.T.; Hinzman, L.D.

    2013-01-01

    The vast amount of organic carbon (OC) stored in soils of the northern circumpolar permafrost region is a potentially vulnerable component of the global carbon cycle. However, estimates of the quantity, decomposability, and combustibility of OC contained in permafrost-region soils remain highly uncertain, thereby limiting our ability to predict the release of greenhouse gases due to permafrost thawing. Substantial differences exist between empirical and modeling estimates of the quantity and distribution of permafrost-region soil OC, which contribute to large uncertainties in predictions of carbon–climate feedbacks under future warming. Here, we identify research challenges that constrain current assessments of the distribution and potential decomposability of soil OC stocks in the northern permafrost region and suggest priorities for future empirical and modeling studies to address these challenges.

  2. A study of the physical-chemical mechanisms and variables which affect the transport of inorganic and organic heterogeneous systems: Annual progress report for 1986-1987

    SciTech Connect

    Zeltner, W.A.

    1987-01-01

    Goal is to investigate the reaction mechanisms and key nonbiological variables which affect the partitioning of microcontaminants between aqueous solutions and solid phase adsorbents. The primary technique used is cylindrical internal reflection - Fourier transform infrared (CIR-FTIR) spectroscopy, in conjunction with wet chemical adsorption isotherm and electrophoretic mobility measurements. CIR-FTIR study of the adsorption of phenol, benzoic acid and derivatives on goethite indicated that phenol and o-nitrophenol do not adsorb. Two separate adsorption mechanisms were observed for five other organics: (1) bidentate adsorption; (2) chelate adsorption along crystal edges. Phosphate adsorption was also studied using CIR-FTIR, with a bidentate adsorption mechanism also indicated. Another aspect of this investigation is to determine the effect of possible particle aggregation on adsorption. This aspect requires the use of a Matec Instruments System 8010, which is currently being purchased. 4 refs.

  3. Production and turnover of suspended organic detritus in the coastal water of the southeastern continental shelf: Progress report, June 1, 1988--May 31, 1989

    SciTech Connect

    Pomeroy, L.R.

    1988-12-01

    As one of a group cooperative research projects on the southeastern continental shelf, this project is concerned with specific aspects of microbial processes and related phenomena that influence the fate of particulate organic materials naturally produced on the continental shelf. The projects of other grantees encompass the dynamics of the shelf from physical oceanography to biology. The integrated information as a whole will be useful in understanding the potential fate of a variety of energy related pollutants that may be released in continental shelf waters. With a focus on events on the southeastern continental shelf and their boundary conditions (Gulf Stream dynamics; river and estuarine processes), we form an interface between studies of oceanic processes such as GOFS and WOCE, and studies of processes at the land-sea boundary. During this grant year we completed two research cruises on the southeastern continental shelf on R/V Blue Fin, and processed data from previous cruises.

  4. Progressive multiple sclerosis

    PubMed Central

    Ontaneda, Daniel; Fox, Robert J.

    2015-01-01

    Purpose to Review To highlight the pathological features and clinical aspects of progressive multiple sclerosis (PMS). To highlight results of clinical trial experience to date and review ongoing clinical trials and perspective new treatment options. Explain the challenges of clinical trial design in PMS. Recent Findings MS has been identified as a chronic immune mediated disease, and the progressive phase of the disease appears to have significant neurodegenerative mechanisms. The classification of the course of PMS has been re-organized into categories of active vs. inactive inflammatory disease and the presence vs. absence of gradual disease progression. This differentiation allows clearer conceptualization of PMS and possibly even more efficient recruitment of PMS subjects into clinical trials. Clinical trial experience to date in PMS has been negative with anti-inflammatory medications used in relapsing MS. Simvastatin was recently tested in a phase II trial and showed a 43% reduction on annualized atrophy progression in secondary progressive MS. Ongoing PMS trials are currently being conducted with the phosphodiesterase inhibitor ibudilast, S1P modulator siponimod, and anti-B-cell therapy ocrelizumab. Several efforts for development of outcome measures in PMS are ongoing. Summary PMS represents a significant challenge, as the pathogenesis of the disease is not well understood, no validated outcome metrics have been established, and clinical trial experience to date has been disappointing. Advances in the understanding of the disease and lessons learned in previous clinical trials are paving the way for successful development of disease modifying agents for this disease. PMID:25887766

  5. Progressing towards more quantitative analytical pyrolysis of soil organic matter using molecular beam mass spectroscopy of whole soils and added standards

    SciTech Connect

    Haddix, Michelle L.; Magrini-Bair, Kim; Evans, Robert J.; Conant, Richard T.; Wallenstein, Matthew D.; Morris, Sherri J.; Calderón, Francisco; Paul, Eldor A.

    2016-12-01

    Soil organic matter (SOM) is extremely complex. It is composed of hundreds of different organic substances and it has been difficult to quantify these diverse substances in a dynamic-ecosystem functioning standpoint. Analytical pyrolysis has been used to compare chemical differences between soils, but its ability to measure the absolute amount of a specific compound in the soil is still in question. Our objective was to assess whether utilizing pyrolysis-molecular beam mass spectroscopy (py-MBMS) to define the signature of known reference compounds (adenine, indole, palmitic acid, etc.) and biological samples (chitin, fungi, cellulose, etc.) separately and when added to whole soils it was possible to make py-MBMS more quantitative. Reference compounds, spanning a wide variety of compound categories, and biological samples, expected to be present in SOM, were added to three soils from Colorado, Ohio, and Massachusetts that have varying total C, % clay, and clay type. Py-MBMS, a rapid analysis technique originally developed to analyze complex biomolecules, flash pyrolyzes soil organic matter to form products that are often considered characteristic of the original molecular structure. Samples were pyrolyzed at 550 degrees C by py-MBMS. All samples were weighed and %C and %N determined both before and after pyrolysis to evaluate mass loss, C loss, and N loss for the samples.An average relationship of r2 = 0.76 (P = 0.005) was found for the amount of cellulose added to soil at 25, 50, and 100% of soil C relative to the ion intensity of select mass/charge of the compound.There was a relationship of r2 = 0.93 (P < 0.001) for the amount of indole added to soil at 25, 50, and 100% of soil C and the ion intensity of the associated mass variables (mass/charge). Comparing spectra of pure compounds with the spectra of the compounds added to soil and isolated clay showed that interference could occur based on soil type and compound with the Massachusetts soil with high C (55

  6. [Regulation of alternative CO{sub 2} fixation pathways in prokaryotic and eukaryotic photosynthetic organisms]. Progress report, June 15, 1991--June 14, 1993

    SciTech Connect

    Tabita, R.

    1993-12-31

    The goal of this project to determine how photosynthetic microorganisms regulate the assimilation of CO{sub 2} via pathways alternative to the usual Calvin-Benson-Bassham reductive pentose phosphate scheme, particularly in the molecular basis for switches in CO{sub 2} metabolic paths. We have identified proteins on one-dimensional and two-dimensional SDS gels that appear differentially expressed in R. sphaeroides strain 16PHC which may be due to a mutation or change in some locus that controls the expression of several genes and their products. Similar observations were made relative to R. rubrum I-19 and the wild-type, namely that additional protein bands were observed in extracts of I-19 compared to the wild-type when both were grown photoheterotrophically with malate as electron donor and CO{sub 2} as the obligatory electron acceptor. The results of Tn5 mutagenesis of R. sphaeroides 16PHC resulted in the isolation of several strains that effectively changed back to the 16 phenotype; i.e., no malate-dependent phototrophic growth with CO{sub 2} as electron acceptor. We have found that both wild-type R. sphaeroides and R. rubrum, and the respective RubisCO negative mutant strains, are all capable of photolithoautotrophic growth using reduced sulfur compounds as electron donors and CO{sub 2} as the sole carbon source and electron acceptor. The fact that the RubisCO negative are capable of photoautotrophic growth is an exciting development for us because it proves that alternative or nonCalvin CO{sub 2} fixation pathways are extremely important to the overall carbon metabolism of these organisms. Moreover, wild-type strains turn off the synthesis of RubisCO under these cultural conditions. Thus, there appears to be separate autotrophic CO{sub 2} fixation pathways in these organisms, and a major emphasis has been placed to identify how these bacteria can grow autotrophically and fix CO{sub 2} in the absence of RubisCO.

  7. The influence of interfacial properties on two-phase liquid flow of organic contaminants in groundwater. Progress report, January 1, 1991--August 31, 1991

    SciTech Connect

    Hayes, K.F.; Demond, A.H.

    1991-08-01

    An improved understanding of the factors influencing the movement of a separate organic liquid phase in groundwater aquifers is important to the US Department of Energy`s efforts to alleviate groundwater contamination by many common solvents. The overall objective of this project is to investigate how changes in interfacial chemical properties affect two-phase flow relationships. Specifically, the objective is to develop a quantitative theory that will enable the prediction of changes in the capillary pressure-saturation relationship, a fundamental constitutive relationship in multiphase flow modeling, from changes in interfacial properties through a knowledge of their effect on wettability. The work over the past eight months of the project summarized here shows the interrelationship between the surface chemical properties of sorption, electrophoretic mobility, contact angle, surface tension and capillary pressure, and how the effects on capillary pressure might be predicted on the basis of surface tension and contact angle. The model system we have been examining consists of o-xylene, water, silica sand, and cetyltrimethylammonium bromide (CTAB), in which all three interfacial tensions of the system change.

  8. Solitary Bone Plasmacytoma Progressing into Retroperitoneal Plasma Cell Myeloma with No Related End Organ or Tissue Impairment: A Case Report and Review of the Literature

    PubMed Central

    Tikku, Gargi; Jain, Monica; Mridha, Asit; Grover, Rajesh

    2014-01-01

    Solitary bone plasmacytomas and plasma cell myeloma are clonal proliferations of plasma cells. Many patients with solitary bone plasmacytomas develop plasma cell myeloma on follow-up. We present a case of a 70-year-old man who presented with fracture and a lytic lesion in the subtrochanteric region of the left femur and was assigned a diagnosis of solitary bone plasmacytoma. He received local curative radiotherapy. However, 4 months later his serum M protein and β2-microglobulin levels increased to 2.31 g/dL and 5.965 mg/L, respectively. He complained of abdominal fullness and constipation. Ultrasound and non-contrast CT imaging revealed multiple retroperitoneal masses. Colonoscopic examination was normal. Biopsy of the a retroperitoneal mass confirmed it to be a plasmacytoma. Repeat hemogram, blood urea, serum creatinine, skeletal survey, and bone marrow examination revealed no abnormalities. This is an unusual presentation of plasma cell myeloma, which manifested as multiple huge extramedullary retroperitoneal masses and arose from a solitary bone plasmacytoma, without related end organ or tissue impairment and bone marrow plasmacytosis. The patient succumbed to his disease 8 months after the appearance of the retroperitoneal masses. This case highlights the importance of close monitoring of patients diagnosed with solitary bone plasmacytoma with increased serum M protein and serum β2-microglobulin levels, so that early therapy can be instituted to prevent conversion to plasma cell myeloma. PMID:25330522

  9. Solitary bone plasmacytoma progressing into retroperitoneal plasma cell myeloma with no related end organ or tissue impairment: a case report and review of the literature.

    PubMed

    Tikku, Gargi; Jain, Monica; Mridha, Asit; Grover, Rajesh

    2014-09-05

    Solitary bone plasmacytomas and plasma cell myeloma are clonal proliferations of plasma cells. Many patients with solitary bone plasmacytomas develop plasma cell myeloma on follow-up. We present a case of a 70-year-old man who presented with fracture and a lytic lesion in the subtrochanteric region of the left femur and was assigned a diagnosis of solitary bone plasmacytoma. He received local curative radiotherapy. However, 4 months later his serum M protein and β2-microglobulin levels increased to 2.31 g/dL and 5.965 mg/L, respectively. He complained of abdominal fullness and constipation. Ultrasound and non-contrast CT imaging revealed multiple retroperitoneal masses. Colonoscopic examination was normal. Biopsy of the a retroperitoneal mass confirmed it to be a plasmacytoma. Repeat hemogram, blood urea, serum creatinine, skeletal survey, and bone marrow examination revealed no abnormalities. This is an unusual presentation of plasma cell myeloma, which manifested as multiple huge extramedullary retroperitoneal masses and arose from a solitary bone plasmacytoma, without related end organ or tissue impairment and bone marrow plasmacytosis. The patient succumbed to his disease 8 months after the appearance of the retroperitoneal masses. This case highlights the importance of close monitoring of patients diagnosed with solitary bone plasmacytoma with increased serum M protein and serum β2-microglobulin levels, so that early therapy can be instituted to prevent conversion to plasma cell myeloma.

  10. Production and turnover of suspended organic detritus in the coastal water of the southeastern continental shelf: Progress report, June 1, 1986 to May 31, 1987

    SciTech Connect

    Pomeroy, L.R.

    1986-12-01

    We are investigating the physics, chemistry and biology of the southeastern continental shelf, so energy-related impacts may be predicted or evaluated. While the study of water movement is basic to understanding the movement of water-borne pollutants, pollutants are frequently associated with particles. However, the transport and transformation of pollutants is strongly influenced by biological processes which create and destroy organic particles. The goals of this project are to understand and describe the biological processes which influence particle distribution and transport and their relation to physical transport processes. We have described the effects of water movements on the ecological processes on the shelf in terms of bacterial numbers, chlorophyll content, and other parameters of biomass and activity. We have sampled both the nearshore region of water of reduced salinity, influenced by river discharge, and the outer continental shelf, which is strongly influenced by the Gulf Stream. We are currently engaged in evaluating the interaction of these two systems, their effects on water movement on the continental shelf, and the biological consequences.

  11. Solubilization of trace organics in block copolymer micelles for environmental separation using membrane extraction principles. Progress report, May 1, 1992--December 31, 1992

    SciTech Connect

    Hatton, T.A.

    1992-12-01

    The solubilization of a range of polycyclic aromatic hydrocarbons in block copolymer micelles has been studied as a function of polymer composition, architecture, and temperature. Micelle formation is favored at high temperatures, leading to significant enhancements in solubilization capacity. At low temperatures, however, micelles do not form and the solubilization capacity of the block copolymer solution for the organics is low; this provides a convenient method for the regeneration of micellar solutions used as ``solvents`` in the treatment of contaminated feed streams using membrane extraction principles. It has also been shown (in collaboration with K.P. Johnston of University of Texas, Austin) that supercritical CO{sub 2} can be used effectively for micelle regeneration. Theoretical calculations of the structure of block copolymer micelles in the presence and absence of solutes using self-consistent mean-field lattice theories have successfully captured the trends observed with changing polymer composition and architecture, often quantitatively. The temperature and composition dependence of the micellar properties were determined by allowing the individual polymer segments to assume both polar and non-polar conformations.

  12. Effects of Electromagnetic Fields on Fish and Invertebrates: Task 2.1.3: Effects on Aquatic Organisms - Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy

    SciTech Connect

    Woodruff, Dana L.; Schultz, Irvin R.; Marshall, Kathryn E.; Ward, Jeffrey A.; Cullinan, Valerie I.

    2012-05-01

    This fiscal year (FY) 2011 progress report (Task 2.1.3 Effects on Aquatic Organisms, Subtask 2.3.1.1 Electromagnetic Fields) describes studies conducted by PNNL as part of the DOE Wind and Water Power Program to examine the potential effects of electromagnetic fields (EMF) from marine and hydrokinetic devices on aquatic organisms, including freshwater and marine fish and marine invertebrates. In this report, we provide a description of the methods and results of experiments conducted in FY 2010-FY 2011 to evaluate potential responses of selected aquatic organisms. Preliminary EMF laboratory experiments during FY 2010 and 2011 entailed exposures with representative fish and invertebrate species including juvenile coho salmon (Oncorhynchus kisutch), Atlantic halibut (Hippoglossus hippoglossus), California halibut (Paralicthys californicus), rainbow trout (Oncorhynchus mykiss), and Dungeness crab (Metacarcinus magister). These species were selected for their ecological, commercial, and/or recreational importance, as well as their potential to encounter an MHK device or transmission cable during part or all of their life cycle. Based on previous studies, acute effects such as mortality were not expected to occur from EMF exposures. Therefore, our measurement endpoints focused on behavioral responses (e.g., detection of EMF, interference with feeding behavior, avoidance or attraction to EMF), developmental changes (i.e., growth and survival from egg or larval stage to juvenile), and exposure markers indicative of physiological responses to stress. EMF intensities during the various tests ranged from 0.1 to 3 millitesla, representing a range of upper bounding conditions reported in the literature. Experiments to date have shown there is little evidence to indicate distinct or extreme behavioral responses in the presence of elevated EMF for the species tested. Several developmental and physiological responses were observed in the fish exposures, although most were not

  13. Control of the accumulation of non-process elements and organic compounds in pulp mills with bleach filtrate reuse. Milestones and progress, Quarter 9 (July 1--September 30, 1998)

    SciTech Connect

    Frederick, W.J.; Laver, M.L.; Rorrer, G.L.; Rudie, A.W.; Schmidl, W.

    1998-12-31

    The two approach changes that were discussed and recommended in the Quarter 8 (April 1--June 30, 1998) progress report have been implemented in the current project plan. The OLI software has been used to develop a preliminary process model for predicting the distribution of NPE`s in a two stage brownstock washer, and the OLI database has been upgraded to include improved chemical equilibrium data for metal-organic interactions. This exercise served as a tool to evaluate the data and methods developed in this study, and to demonstrate its utility to industry. The Weyerhaeuser-NAELS software has also been applied to predicting inorganic solubility behavior. Task C-1.2, Estimation of unavailable thermodynamic parameters (scheduled completion date: 12/97), has been combined with Task D-2.1, Evaluation of the estimation procedure (scheduled completion date: 3/99) with a new scheduled completion date of 8/99. A model for the adsorption of metal ions on wood pulp fibers will include transport effects as well as adsorption equilibrium, and will be combined with a brownstock washer model to evaluate its predictive capability in comparison with mill data, and to demonstrate the applicability of the results obtained in this project. Three tasks are behind schedule: Task A-2.3, Measurement of stability constants for wood organics with metal ions (scheduled completion date: 6/98), Task B-2.1, Measure metal adsorption isotherms on wood pulp (scheduled completion date: 9/97), and Task B-2.3, Measure metal ion adsorption kinetics for strongly adsorbing metal species (scheduled completion date: 3/98). The reasons and expected completion dates are discussed in the Performance Variances and Open Items section. All other tasks are either completed, on, or ahead of schedule.

  14. Effects of Electromagnetic Fields on Fish and Invertebrates Task 2.1.3: Effects on Aquatic Organisms Fiscal Year 2012 Progress Report Environmental Effects of Marine and Hydrokinetic Energy

    SciTech Connect

    Woodruff, Dana L.; Cullinan, Valerie I.; Copping, Andrea E.; Marshall, Kathryn E.

    2013-05-20

    Energy generated by the world’s oceans and rivers offers the potential to make substantial contributions to the domestic and global renewable energy supply. However, the marine and hydrokinetic (MHK) energy industry faces challenges related to siting, permitting, construction, and operation of pilotand commercial-scale facilities. One of the challenges is to understand the potential effects to marine organisms from electromagnetic fields, which are produced as a by-product of transmitting power from offshore to onshore locations through underwater transmission cables. This report documents the progress of the third year of research (fiscal year 2012) to investigate environmental issues associated with marine and hydrokinetic energy (MHK) generation. This work was conducted by Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) Wind and Water Technologies Office. The report addresses the effects of electromagnetic fields (EMFs) on selected marine species where significant knowledge gaps exist. The species studied this fiscal year included one fish and two crustacean species: the Atlantic halibut (Hippoglossus hippoglossus), Dungeness crab (Metacarcinus magister), and American lobster (Homarus americanus).

  15. Progressive Multifocal Leukoencephalopathy

    MedlinePlus

    ... clumsiness; progressive weakness; and visual, speech, and sometimes personality changes. The progression of deficits leads to life- ... clumsiness; progressive weakness; and visual, speech, and sometimes personality changes. The progression of deficits leads to life- ...

  16. Continuous Progress Program Inservice Materials.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL.

    The Continuous Progress Program of the Board of Education for the City of Chicago focuses on the improvement of education for the individual child and the upgrading of educational practices and techniques. The philosophy of the program is based on the individualized rate of teaching and learning of the pupil. Its planning and organization is…

  17. Gaining Momentum, Losing Ground. Progress Report, 2008

    ERIC Educational Resources Information Center

    Business Roundtable, 2008

    2008-01-01

    This report presents an update of the progress of Tapping America's Potential (TAP), a coalition of 15 of the nation's leading business organizations, and assesses three years' progress since 2005 in working towards the goal of doubling the number of students earning bachelor's degrees in science, technology, engineering and math (STEM) by 2015.…

  18. EDITORIAL: Catalysing progress Catalysing progress

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-01-01

    Examples of the merits of blue-sky research in the history of science are legion. The invention of the laser, celebrating its 50th anniversary this year, is an excellent example. When it was invented it was considered to be 'a solution waiting for a problem', and yet the level to which it has now infiltrated our day-to-day technological landscape speaks volumes. At the same time it is also true to say that the direction of research is also at times rightly influenced by the needs and concerns of the general public. Over recent years, growing concerns about the environment have had a noticeable effect on research in nanotechnology, motivating work on a range of topics from green nanomaterial synthesis [1] to high-efficiency solar cells [2] and hydrogen storage [3]. The impact of the world's energy consumption on the welfare of the planet is now an enduring and well founded concern. In the face of an instinctive reluctance to curtail habits of comfort and convenience and the appendages of culture and consumerism, research into renewable and more efficient energy sources seem an encouraging approach to alleviating an impending energy crisis. Fuel cells present one alternative to traditional combustion cells that have huge benefits in terms of the efficiency of energy conversion and the limited harmful emissions. In last week's issue of Nanotechnology, Chuan-Jian Zhong and colleagues at the State University of New York at Binghamton in the USA presented an overview of research on nanostructured catalysts in fuel cells [4]. The topical review includes insights into the interactions between nanoparticles and between nanoparticles and their substrate as well as control over the composition and nanostructure of catalysts. The review also serves to highlight how the flourishing of nanotechnology research has heralded great progress in the exploitation of catalysts with nanostructures ingeniously controlled to maximize surface area and optimize energetics for synthesis

  19. Transition projects FY 1995 multi-year program/fiscal year work plan WBS 1.3.1. and 7.1

    SciTech Connect

    Not Available

    1994-09-01

    The primary Transition Projects mission is to deactivate facilities on the Hanford site, in preparation for decontamination and decommissioning, and secondarily to provide safe and secure storage of special nuclear materials, nuclear materials, and nuclear fuel. Transition projects will protect the health and safety of the public and of workers, protect the environment, and provide beneficial use of the facilities and other resources. Goals include the following: Achieve deactivation of facilities for transfer to the Hanford Surplus Facility Program, suing PUREX plant deactivation as a model; Achieve excellence in the conduct of operations and maintenance of nuclear facilities in support of the Hanford Site Mission; manage nuclear materials in a safe and secure condition; treat nuclear materials as necessary and store onsite in long-term interim safe storage awaiting a final disposition decision. Description of the program and projects is included.

  20. Environmental support FY 1995 multi-year program plan/fiscal year work plan WBS 1.5.2/7.4.11

    SciTech Connect

    Moore, D.A.

    1994-09-01

    The multi-Year Program Plan (MYPP) is the programmatic planning baseline document for technical, schedule, and cost data. The MYPP contains data by which all work is managed, performed and controlled. The integrated planning process, defined by RL, is redicted on establishment of detailed data in the MYPP. The MYPP includes detailed information for the data elements including Level II critical path schedules, cost estimate detail, and updated technical data to be done annually. There will be baseline execution year and out year approval with work authorization for execution. The MYPP will concentrate on definition of the scope, schedule, cost and program element level critical path schedules that show the relationship of planned activities. The Fiscal Year Work Plan (FYWP) is prepared for each program to provide the basis for authorizing fiscal year work. The MYPP/FYWP will be structured into three main areas: (1) Program Overview; (2) Program Baselines; (3) Fiscal Year Work Plan.

  1. Department of the Navy FY 1995 Budget Estimates, DoD Base Realignment and Closure Program III (1993 Commission), Justification Data Submitted to Congress February 1994

    DTIC Science & Technology

    1994-02-01

    for uninterruptable power system (UPS), security fencing, loading platform, roof-mounted antenna supports, relocation of pod storage, parking, and...raised computer flooring, monorail, provisions for uninterruptible power system (UPS) and intrusion detection system (IDS); pre-engineered metal...MAINTENANCE SHELTER ... .......... SF 6,000 95.00 ( 570 ) LINE MAINTENANCE SHELTER CONVERSION .... ..... SF 3,420 52.00 ( 180) POWER CHECK PAD WITH SOUND

  2. Department of the Navy FY 1995 Budget Estimates. Military Construction and Family Housing Program. Justification Data Submitted to Congress February 1994

    DTIC Science & Technology

    1994-02-01

    6.000 NAVAL AIR FACILITY. 9 EL CENTRO. CALIFORNIA 213 POTABLE WATER DISTRIBUTION 1,500 1,500 50 132 SYSTEM UPGRADES 214 WASTEWATER TREATMENT PLANT 1.500...46.115 WASHINGTON PUGET SOUND NAVAL SHIPYARD. 85 BREMERTON. WASHINGTON 240 INDUSTRIAL WASTEWATER 3.200 3.200 35 139 TREATMENT FACILITY 295 UTILITIES AND...ISLAND. WASHINGTON 124 FIRE FIGHTING TRAINING 1.400 1.400 35 103 FACILITY 126 INDUSTRIAL WASTEWATER 1.400 1.400 40 140 PRETREATMENT FACILITY 125 WASTEWATER

  3. DoD Base Realignment and Closure Account 2. DISA (BRAC 93) FY 1995 Budget Estimates. Justification Data Submitted to Congress February 1994

    DTIC Science & Technology

    1994-02-01

    costs, Voluntary Early Retirement Authority/Voluntary Separation Incentive Pay, and severance pay for the estimated 130 civilian separations in FY95...Operation and Maintenance: Includes civilian PCS, Priority Placement costs, Voluntary Early Retirement Authority/Voluntary Separation Incentive Pay... Early Retirement Authority/Voluntary Separation Incentive Pay, and severance pay for the estimated 112 civilian separations in FY95. Also includes

  4. Temperature profile analysis for Amargosa Valley wells LWS-A, ASH-B, and MSH-C. DOE UGTA RI/FS geothermal gradient study results FY 1995

    SciTech Connect

    Gillespie, D.

    1995-09-01

    The purpose of this investigation is to estimate vertical fluid flux rates in saturated units penetrated by selected wells at the Nevada Test Site (NTS) using geothermal gradient data. Estimates of vertical fluid flux rates are critical in developing models for contaminate flow within, recharge potential to, and discharge from the groundwater system at the NTS. If temperature in the well is in equilibrium with the surrounding rocks, it is possible to detect the vertical flow of groundwater from the well`s thermal profile. Heat in the subsurface is transported by conduction through the rock and by advection caused by subsurface water movement. Units in which vertical flow is occurring will produce a curve in the thermal profile within the well. Prior to the implementation of the Underground Test Area Remedial Investigation/Feasibility Study (UGTA RI/FS), investigation of thermal data from wells at the NTS was hindered by the completion of wells as open holes or without casing cemented in place. The open-hole type of completion allows cross-flow within the wellbore which can yield information about relative pressures between connected aquifers, but which renders thermal gradient data essentially useless, or at best highly suspect for interpreting in situ groundwater movement. Wells recently completed in the Department of Energy (DOE) Environmental Restoration (ER) Program have been completed with casing cemented to the surface (to prohibit cross-flow between units in the annular space between the casing and the wellbore) and with completion zones open to a single hydrologic horizon. This type of completion results in temperature gradient profiles more representative of actual thermal conditions in the units penetrated by the well. Results are presented of temperature profiles of 3 wells located in the Death Valley Groundwater Basin, outside the southern border of the NTS.

  5. State Higher Education Finance in Ohio and the United States, FY 1995 to FY 2009: Results from 2009 SHEEO Finance Survey

    ERIC Educational Resources Information Center

    Ohio Board of Regents, 2010

    2010-01-01

    This report summarizes full-time equivalent enrollment, state and local higher education appropriations, and tuition revenue data collected through the State Higher Education Executive Officers (SHEEO) finance survey. The intent is to examine trends in higher education revenues per FTE and compare Ohio and U.S. outcomes. All dollar figures…

  6. Ecological studies related to the construction of the Defense Waste Processing Facility on the Savannah River Site. Annual report, FY-1994 and FY-1995

    SciTech Connect

    1995-12-01

    The Savannah River Ecology Laboratory initiated ecological studies related to the construction of the DWPF on the SRS in FY-1979. Two areas have been used for biological surveys and long-term monitoring: the DWPF construction site (S-Area and Z-Area), and two control sites (Rainbow Bay and Tinker Creek). The Rainbow Bay study area and S-Area are located within 5 km of each other on the SRS, and both once contained Carolina bays which were very similar ecologically. One goal of the SREL`s faunal studies is to compare the natural variation in amphibian populations at the Rainbow Bay control site to the variation observed at the human-altered site (Sun Bay, formerly on the DWPF construction site). Pre-construction biological surveys included data on vegetation, birds, mammals, amphibians, reptiles, fish and several invertebrate groups. No species on the Federal Endangered or Threatened lists were found on either site, but several plants and animals of threatened or special-concern status in South Carolina were present and the gopher frog (Rana areolata) currently is being considered for federal listing. Continuing studies are directed towards assessing construction impacts on the biota and towares modeling the effects of alteration of wetland hydroperiod on the biota. Primary emphasis is being paced on evaluation the effectiveness of mitigation measures undertaken by DOE.

  7. Transition projects FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP) WBS 1.3.1 and 7.1. Volume 2

    SciTech Connect

    Cartmell, D.B.

    1994-09-01

    This document contains information concerning the management of the Hanford Reservation. Information concerning the departmental schedules is presented in chart form. The following departmental schedules are included: The B-plant/Cesium Capsule Recovery, 300 Area Fuel Supply Program, Plutonium Finishing Plant, and Program and Environmental Management.

  8. Transition projects FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP) WBS 1.3.1 and 7.1. Volume 4

    SciTech Connect

    Cartmell, D.B.

    1994-09-01

    This reference contains information about the deactivation of the Purex Process Plant located on the Hanford Reservation. This document consists of a tabular schedule of events covering the next three years.

  9. Evaluation of improved technologies for the removal of {sup 90}Sr and {sup 137}Cs from process wastewater and groundwater: FY 1995 status

    SciTech Connect

    Bostick, D.T.; Arnold, W.D. Jr.; Burgess, M.W.; McTaggart, D.R.; Taylor, P.A.; Guo, B.

    1996-03-01

    A number of new sorbents are currently being developed for the removal of {sup 90}Sr and {sup 137}Cs from contaminated, caustic low-level liquid waste (LLLW). These sorbents are potentially promising for use in the cleanup of contaminated groundwater and process wastewater containing the two radionuclides. The goal of this subtask is to evaluate the new sorbents to determine whether their associated treatment technology is more selective for the decontamination of wastewater streams than that of currently available processes. Activities during fiscal year 1995 have included completing the characterization of the standard treatment technology, ion exchange on chabazite zeolite. Strontium and cesium sorption on sodium-modified zeolite was observed in the presence of elevated concentrations of wastewater components: sodium, potassium, magnesium, and calcium. The most significant loss of nuclide sorption was noted in the first 0- to 4-meq/L addition of the cations to a wastewater simulant. Radionuclide sorption on the pretreated zeolite was also determined under dynamic flow conditions. Resorcinol-formaldehyde (R-F) resin, which was developed at the Savannah River Site, was selected as the first new sorbent to be evaluated for wastewater treatment. Nuclide sorption on this resin was greater when the resin had been washed with ultrapure water and air dried prior to use.

  10. Development of a three-dimensional ground-water model of the Hanford Site unconfined aquifer system: FY 1995 status report

    SciTech Connect

    Wurstner, S.K.; Thorne, P.D.; Chamness, M.A.; Freshley, M.D.; Williams, M.D.

    1995-12-01

    A three-dimensional numerical model of ground-water flow was developed for the uppermost unconfined aquifer at the Hanford Site in south-central Washington. Development of the model is supported by the Hanford Site Ground-Water Surveillance Project, managed by the Pacific Northwest National Laboratory, which is responsible for monitoring the sitewide movement of contaminants in ground water beneath the Hanford Site. Two objectives of the Ground-Water Surveillance Project are to (1) identify and quantify existing, emerging, or potential ground-water quality problems, and (2) assess the potential for contaminants to migrate from the Hanford Site through the ground-water pathway. Numerical models of the ground-water flow system are important tools for estimating future aquifer conditions and predicting the movement of contaminants through ground water. The Ground-Water Surveillance Project has supported development and maintenance of a two-dimensional model of the unconfined aquifer. This report describes upgrade of the two-dimensional model to a three-dimensional model. The numerical model is based on a three-dimensional conceptual model that will be continually refined and updated as additional information becomes available. This report presents a description of the three-dimensional conceptual model of ground-water flow in the unconfined aquifer system and then discusses the cur-rent state of the three-dimensional numerical model.

  11. Economic transition FY 1995 Multi-Year Program Plan (MYPP)/Fiscal Year Work Plan (FYWP) WBS 7.4.9

    SciTech Connect

    Schwenk, R.M.

    1994-09-01

    The mission of the WHC Economic Transition Center is to support Hanford`s cleanup mission and to leverage the assets of that mission to promote diversification and long-term sustainability of the regional economy and workforce. Conducting an economic transition program is imperative at sites such as Hanford, which are faced with transition from a defense production mission to a massive cleanup mission, followed by rampdown and site closure. At issue are the human and physical resources of the Site and the final disposition of those resources. Without an effective economic transition program, the federal government will have invested billions of dollars to achieve environmental regulatory compliance without generating any greater return on investment. With an effective economic transition program, the potential exists to redeploy the highly skilled, well-trained, and educated workforce developed and utilized during the Site`s cleanup mission and find productive uses for land, facilities, and equipment. The Economic Transition Center has been divided into the following business areas: outsourcing; spinoffs; technology acquisition; technology transfer; conversion; and cross-cutting partnerships. A work package has been developed for each of these business areas in this Fiscal Year Work Plan.

  12. Department of the Navy FY 1995 Budget Estimates, DoD Base Closure and Realignment Program 2 (1991 Commission), Justification Data Submitted to Congress February 1994

    DTIC Science & Technology

    1994-02-01

    0 0 0 Operations 0 0 0 0 0 0 0 Environmental I14315 ) 17406) 20154 9867211 8052)1 17600 861991 Studies 1575 1500 1100 500 0 0 4675 Compliance 1350...0 0 0 0 0 0 Operation 0 0 0 0 0 0 0 Environmental 14315i1 1740611 20154 l[ 8672 l[ 802 ![ 17600 861991 Studies 1575 1500 1100 500 0 0 4675 Compliance

  13. Primary Progressive Aphasia

    MedlinePlus

    Primary progressive aphasia Overview By Mayo Clinic Staff Primary progressive aphasia (uh-FAY-zhuh) is a rare nervous system (neurological) syndrome ... your ability to communicate. People with primary progressive aphasia can have trouble expressing their thoughts and understanding ...

  14. Challenges in organ transplantation.

    PubMed

    Beyar, Rafael

    2011-04-01

    Organ transplantation has progressed tremendously with improvements in surgical methods, organ preservation, and pharmaco-immunologic therapies and has become a critical pathway in the management of severe organ failure worldwide. The major sources of organs are deceased donors after brain death; however, a substantial number of organs come from live donations, and a significant number can also be obtained from non-heart-beating donors. Yet, despite progress in medical, pharmacologic, and surgical techniques, the shortage of organs is a worldwide problem that needs to be addressed internationally at the highest possible levels. This particular field involves medical ethics, religion, and society behavior and beliefs. Some of the critical ethical issues that require aggressive interference are organ trafficking, payments for organs, and the delicate balance in live donations between the benefit to the recipient and the possible harm to the donor and others. A major issue in organ transplantation is the definition of death and particularly brain death. Another major critical factor is the internal tendency of a specific society to donate organs. In the review below, we will discuss the various challenges that face organ donation worldwide, and particularly in Israel, and some proposed mechanisms to overcome this difficulty.

  15. [Charles Darwin and the problem of evolutionary progress].

    PubMed

    Iordanskiĭ, N N

    2010-01-01

    According to Ch. Darwin's evolutionary theory, evolutionary progress (interpreted as morpho-physiological progress or arogenesis in recent terminology) is one of logical results of natural selection. At the same time, natural selection does not hold any factors especially promoting evolutionary progress. Darwin emphasized that the pattern of evolutionary changes depends on organism nature more than on the pattern of environment changes. Arogenesis specificity is determined by organization of rigorous biological systems - integral organisms. Onward progressive development is determined by fundamental features of living organisms: metabolism and homeostasis. The concept of social Darwinism differs fundamentally from Darwin's ideas about the most important role of social instincts in progress of mankind. Competition and selection play secondary role in socio-cultural progress of human society.

  16. News & Views Evaluation of Projects for Basic Research of Scientific Instruments in 2008 Completed NSFC Former President Tang Ao-qing Passed Away Professor Tang Aoqing and NSFC Carbon Nanotube Film-Based Speaker Developed in Tsinghua University Dinosaur Footprint Fossils Discovered in Xinjiang New Method for Early Cancer Diagnosis New Progress Achieved by NSFC Project in Basic Research of Black Hole Physics New progress in Organic FET 67 NSFC-RFBR Cooperative Projects Approved for 2008 Spin Configuration and Super-exchange Mechanism in Molecular Magnets Observed NSFC Strengthens its Funding in Wenchuan Concerns Go to Disaster's Impact on Economy and Emergency Response Thirty-seven NSFC-KOSEF Cooperative Projects Approved

    NASA Astrophysics Data System (ADS)

    2008-01-01

    Evaluation of Projects for Basic Research of Scientific Instruments in 2008 Completed NSFC Former President Tang Ao-qing Passed Away Professor Tang Aoqing and NSFC Carbon Nanotube Film-Based Speaker Developed in Tsinghua University Dinosaur Footprint Fossils Discovered in Xinjiang New Method for Early Cancer Diagnosis New Progress Achieved by NSFC Project in Basic Research of Black Hole Physics New progress in Organic FET 67 NSFC-RFBR Cooperative Projects Approved for 2008 Spin Configuration and Super-exchange Mechanism in Molecular Magnets Observed NSFC Strengthens its Funding in Wenchuan Concerns Go to Disaster's Impact on Economy and Emergency Response Thirty-seven NSFC-KOSEF Cooperative Projects Approved

  17. Progress in Fully Automated Abdominal CT Interpretation

    PubMed Central

    Summers, Ronald M.

    2016-01-01

    OBJECTIVE Automated analysis of abdominal CT has advanced markedly over just the last few years. Fully automated assessment of organs, lymph nodes, adipose tissue, muscle, bowel, spine, and tumors are some examples where tremendous progress has been made. Computer-aided detection of lesions has also improved dramatically. CONCLUSION This article reviews the progress and provides insights into what is in store in the near future for automated analysis for abdominal CT, ultimately leading to fully automated interpretation. PMID:27101207

  18. Progression of Liver Disease

    MedlinePlus

    ... The Progression of Liver Disease The Progression of Liver Disease There are many different types of liver ... may put your life in danger. The Healthy Liver Your liver helps fight infections and cleans your ...

  19. Reconstructing Progressive Education

    ERIC Educational Resources Information Center

    Kaplan, Andy

    2013-01-01

    The work of Colonel Francis W. Parker, the man whom Dewey called "the father of progressive education," provides a starting point for reconstructing the loose ambiguities of progressive education into a coherent social and educational philosophy. Although progressives have claimed their approach is more humane and sensitive to children, we need…

  20. Benchtop Energetics Progress

    NASA Astrophysics Data System (ADS)

    Fajardo, Mario

    2011-06-01

    We have constructed an apparatus for investigating the reactive chemical dynamics of mg-scale energetic materials samples. We seek to advance the understanding of the reaction kinetics of energetic materials, and of the chemical influences on energetic materials sensitivity. We employ direct laser irradiation, and indirect laser-driven shock, techniques to initiate thin-film explosive samples contained in a high-vacuum chamber. Expansion of the reacting flow into vacuum quenches the chemistry and preserves reaction intermediates for interrogation via time-of-flight mass spectrometry (TOFMS). By rastering the sample coupon through the fixed laser beam focus, we generate hundreds of repetitive energetic events in a few minutes. A detonation wave passing through an organic explosive, such as pentaerythritol tetranitrate (PETN, C5H4N4O12) , is remarkably efficient in converting the solid explosive into final thermodynamically-stable gaseous products (e . g . N2, CO2, H2O...). Termination of a detonation at an explosive-to-vacuum interface produces an expanding pulse of hyperthermal molecular species, with leading-edge velocities ~10 km/s. In contrast, deflagration (subsonic combustion) of PETN in vacuum produces mostly reaction intermediates, such as NO and NO2, with much slower molecular velocities; consistent with expansion-quenched thermal decomposition of PETN. We propose to exploit these differences in product chemical identities and molecular species velocities to provide a chemically-based diagnostic for distinguishing between detonation and deflagration events. In this talk we also report recent progress towards the quantitative detection of hyperthermal neutral species produced by direct laser ablation of aluminum metal and of organic energetic materials, as a step towards demonstrating the ability to discriminate slow reaction intermediates from fast thermodynamically-stable final products. Work done in collaboration with Emily Fossum, Christopher Molek, and

  1. IPY Progress and Prospects

    NASA Astrophysics Data System (ADS)

    Carlson, D.

    2008-12-01

    We can summarize the IPY goals as: (a) make major advances in polar knowledge and understanding; (b) leave a legacy of new or enhanced observational systems, facilities and infrastructure; (c) excite a new generation of polar scientists and engineers, and (d) elicit exceptional interest and participation from polar residents, schoolchildren, the general public, and decision-makers, worldwide. This talk reports on the progress and prospects in each of those areas from an overall international view; separate talks will describe details of future researcher and the IPY outreach efforts. To achieve major advances in knowledge, IPY has entrained the intellectual resources of thousands of scientists, many more than expected, often from 'non- polar' nations, and representing an unprecedented breadth of scientific specialties; integration of those efforts across disciplines to achieve integrated system-level understanding remains a substantial challenge. Many national and international organizations prepare plans to sustain new and improved observational systems, but clear outcomes and the necessary resources remain elusive. International outreach networks gradually build breadth and strength, largely through IPY Polar Science Days and other internationally- coordinated IPY events. A new Association of Polar Early Career Scientists (APECS) devotes talent and energy to shaping the future of polar research. These activities and networks may, with time and with continued international coordination, achieve an exceptional level of interest and participation. In all areas, much work remains.

  2. Progress Report NORSAR Phase 3

    DTIC Science & Technology

    1974-10-11

    PHASE 3 1 July - 30 September 1974 1 AUTHOR’«; Prepared by K.A. Berteussen 9 PERFORMING ORGANIZATION NAME AND ADDRESS NTNF...30 June 1975 F08606-74-C-0049 Norwegian Seismic Array (NORSAR) Phase 3 $900 000.— II October 1974 1 July - 30 September 197 4 Nils Maräs, (02)71...Hi.»,«—, Hl .1 ii.li in im. UM;!..». .1.1 „IM I,„LWII ■Mtffll^ A D/A-00 2 25 2 PROGRESS REPORT NORSAR PHASE

  3. Progress of the LASSO experiment

    NASA Technical Reports Server (NTRS)

    Serene, B. E. H.

    1981-01-01

    The LASSO (Later Synchronisation from Stationary Orbit) experiment, designed to demonstrate the feasibility of achieving time synchronization between remote atomic clocks with an accuracy of one nanosecond or better by using laser techniques for the first time is described. The experiment uses groundbased laser stations and the SIRIO-2 geostationary satellite to be launched towards the end of 1981. The qualification of the LASSO on-board equipment is discussed with a brief description of the electrical and optical test equipment used. The progress of the operational organization is included.

  4. Lung xenotransplantation: recent progress and current status.

    PubMed

    Harris, Donald G; Quinn, Kevin J; Dahi, Siamak; Burdorf, Lars; Azimzadeh, Agnes M; Pierson, Richard N

    2014-01-01

    Xenotransplantation has undergone important progress in controlling initial hyperacute rejection in many preclinical models, with some cell, tissue, and organ xenografts advancing toward clinical trials. However, acute injury, driven primarily by innate immune and inflammatory responses, continues to limit results in lung xenograft models. The purpose of this article is to review the current status of lung xenotransplantation--including the seemingly unique challenges posed by this organ-and summarize proven and emerging means of overcoming acute lung xenograft injury.

  5. Latest Progress in High Power VECSELs

    DTIC Science & Technology

    2013-01-01

    Air Force Academy) 5d. PROJECT NUMBER 2002 5e. TASK NUMBER IH 5f. WORK UNIT NUMBER Y053 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8...PERFORMING ORGANIZATION REPORT NUMBER AFRL-RY-WP-TP-2013-0030 Optoelectronic Technology Branch Aerospace Components & Subsystems Division...platform for multiple applications . This presentation outlines recent progress in VECSELs, measurements, novel cavities, and potential applications for

  6. [Incorporation of an organic MAGIC (Model of Acidification of Groundwater in Catchments) and testing of the revised model using independent data sources]. Progress report, March 16, 1992--September 15, 1992

    SciTech Connect

    Sullivan, T.J.

    1992-09-01

    A project was initiated in March, 1992 to (1) incorporate a rigorous organic acid representation, based on empirical data and geochemical considerations, into the MAGIC model of acidification response, and (2) test the revised model using three sets of independent data. After six months of performance, the project is on schedule and the majority of the tasks outlined for Year 1 have been successfully completed. Major accomplishments to data include development of the organic acid modeling approach, using data from the Adirondack Lakes Survey Corporation (ALSC), and coupling the organic acid model with MAGIC for chemical hindcast comparisons. The incorporation of an organic acid representation into MAGIC can account for much of the discrepancy earlier observed between MAGIC hindcasts and paleolimnological reconstructions of preindustrial pH and alkalinity for 33 statistically-selected Adirondack lakes. Additional work is on-going for model calibration and testing with data from two whole-catchment artificial acidification projects. Results obtained thus far are being prepared as manuscripts for submission to the peer-reviewed scientific literature.

  7. Organic solar cell exploratory research

    NASA Technical Reports Server (NTRS)

    Yalenty, S. J.

    1975-01-01

    Principles governing the photovoltaic effect in organic materials on the molecular level are studied and applied to the design and fabrication of laboratory devices having a photovoltaic organic polymer film as their key element. Progress to date has been in three areas: (1) materials synthesis; (2) apparatus development; and (3) ultra-thin film fabrication.

  8. The self-organizing consciousness.

    PubMed

    Perruchet, Pierre; Vinter, Annie

    2002-06-01

    We propose that the isomorphism generally observed between the representations composing our momentary phenomenal experience and the structure of the world is the end-product of a progressive organization that emerges thanks to elementary associative processes that take our conscious representations themselves as the stuff on which they operate, a thesis that we summarize in the concept of Self-Organizing Consciousness (SOC).

  9. Making Progress as Leaders among University Staff

    ERIC Educational Resources Information Center

    Quah, Cheng Sim; Sim, Sandra Phek Lin

    2014-01-01

    This study examined the overview of how individuals in their respective teams operated and contributed to their organization. This study also identified the salient characteristics of how the respondents made progress as leaders in their respective faculties or departments towards identifying directions for innovative future practice through…

  10. [Lingual involvement in progressive systemic sclerosis].

    PubMed

    Pila Pérez, R; Pila Peláez, R; Pila Peláez, M; Guerra Rodríguez, C; Rojas Casanova, C

    2000-01-01

    A case of a 40 year old female patient who began to present alterations in the tongue and who was diagnosed of Progressive Sclerosis of that organ is presented. The manifestation and diagnostic tools used in this case, as well as the treatment use, is given. The rareness of this disease, which is possible in systemic diseases, stands out.

  11. Progressive dysembryoplastic neuroepithelial tumour.

    PubMed

    Alexander, Hamish; Tannenburg, Anthony; Walker, David G; Coyne, Terry

    2015-01-01

    Dysembryoplastic neuroepithelial tumour (DNET) is a benign tumour characterised by cortical location and presentation with drug resistant partial seizures in children. Recently the potential for malignant transformation has been reported, however progression without malignant transformation remains rare. We report a case of clinical and radiologic progression of a DNET in a girl 10 years after initial biopsy.

  12. Development of more efficacious {Tc}-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceuticals. Annual technical progress report, September 1, 1992--August 31, 1993

    SciTech Connect

    Heineman, W.R.

    1993-05-03

    This research program is detailed at development of more efficacious technetium-99m radiopharmaceuticals for use as imaging agents in diagnostic nuclear medicine. We seek to isolate and develop distinct site imaging agents to provide diagnostic information concerning a given pathological condition. Analytical techniques are being developed to enable complete analysis of radiopharmaceutical preparations so that individual complexes can be characterized with respect to imaging efficacy and to enable a radiopharmaceutical to be monitored after injection into a test animal to determine the species that actually accumulates in an organ to provide the image. Administration of the isolated, single most effective imaging complex, rather than a mixture of technetium-containing complexes, wi-11 minimize radiation exposure to the patient and maximize diagnostic information available to the clinician. This report specifically describes the development of capillary electrophoresis (CE) for characterizating diphosphonate skeletal imaging agents. Advances in the development of electrochemical and fiber optic sensors for Tc and Re imaging agents are described. These sensors will ultimately be capable of monitoring a specific chemical state of an imaging agent in vivo after injection into a test animal by implantation in the organ of interest.

  13. Rapidly progressive Alzheimer disease.

    PubMed

    Schmidt, Christian; Wolff, Martin; Weitz, Michael; Bartlau, Thomas; Korth, Carsten; Zerr, Inga

    2011-09-01

    Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs. Progressive forms of Alzheimer disease have been reported with rapid cognitive decline and disease duration of only a few years. This short review aims to provide an overview of the current knowledge of rapidly progressive Alzheimer disease. Furthermore, we suggest that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.

  14. Rapidly Progressive Dementia

    PubMed Central

    Geschwind, Michael D.; Shu, Huidy; Haman, Aissa; Sejvar, James J.; Miller, Bruce L.

    2009-01-01

    In contrast with more common dementing conditions that typically develop over years, rapidly progressive dementias can develop subacutely over months, weeks, or even days and be quickly fatal. Because many rapidly progressive dementias are treatable, it is paramount to evaluate and diagnose these patients quickly. This review summarizes recent advances in the understanding of the major categories of RPD and outlines efficient approaches to the diagnosis of the various neurodegenerative, toxic-metabolic, infectious, autoimmune, neoplastic, and other conditions that may progress rapidly. PMID:18668637

  15. Analytical Chemistry Division annual progress report for period ending December 31, 1979

    SciTech Connect

    Shults, W.D.; Lyon, W.S.

    1980-05-01

    The progress is reported in the following sections: analytical methodology, mass and emission spectrometry, technical support, bio-organic analysis, nuclear and radiochemical analysis, and quality assurance. (DLC)

  16. PATHWAYS OF MEDICAL PROGRESS.

    PubMed

    Wiggers, C J

    1940-01-12

    During the three decades that have passed, medical science has ascended to a high plateau of achievement. The climb has involved several pathways; among them: (1) the physiological approach toward disease as experiments which nature performs on organisms, (2) the more intelligent interpretation of the functional reactions of the body in disease in accordance with latest discoveries in physiology, (3) the supplementation of observable phenomena through use of laboratory instruments, (4) the assumption of active investigation both on patients and experimental animals by clinicians themselves, (5) the shuttling of problems between clinical and experimental laboratories and (6) correlated research in clinical and physiological departments. As we look down from the heights we have reached, we have reason to be pleased with our progress; but when we look ahead we become aware that there are still high mountain ranges to be climbed. We realize that their ascent can not be accomplished by employing merely the methods, equipment and strategy that have proved successful so far; we must improve the application of principles that are old and well established, and evolve others that are new. Above all, we from laboratories and clinics must join hands to help each other climb; and through correlated team-work overcome the great obstacles that jealous nature places in our way. I have ventured to suggest a few directions which such mutual help may take. They include (1) means by which new fundamental discoveries can be utilized more quickly by clinicians and practitioners of medicine; (2) plans by which younger clinical investigators can be given approximately the same opportunity for training in research technique as their colleagues entering experimental sciences; (3) pleas that the shuttling of problems between hospitals and laboratories of fundamental science may continue in order that the ultimate significance of clinical results may be better understood and that the

  17. Progress for the Paralyzed

    MedlinePlus

    ... this page please turn Javascript on. Feature: NIBIB Robotics Progress for the Paralyzed Past Issues / Spring 2013 ... Paralyzed —The expanding options for paralyzed individuals include: robotic arms spinal cord stimulation improved prosthetic limbs restored ...

  18. Progressive hemifacial atrophy

    PubMed Central

    Sande, Abhijeet; Risbud, Mukund; Kshar, Avinash; Paranjpe, Arati Oka

    2013-01-01

    Progressive hemifacial atrophy, also known as Parry-Romberg Syndrome, is an uncommon degenerative and poorly understood condition. It is characterized by a slow and progressive but self-limited atrophy affecting one side of the face. The incidence and the cause of this alteration are unknown. A cerebral disturbance of fat metabolism has been proposed as a primary cause. Possible factors that are involved in the pathogenesis include trauma, viral infections, heredity, endocrine disturbances and auto-immunity. The most common complications that appear in association to this disorder are: trigeminal neuralgia, facial paresthesia, severe headache and epilepsy. Characteristically, the atrophy progresses slowly for several years and, it becomes stable. The objective of this work is, through the presentation of a clinical case, to accomplish a literature review concerning general characteristics, etiology, physiopathology and treatment of progressive hemifacial atrophy. PMID:23878573

  19. Orion Progress - Spring 2010

    NASA Video Gallery

    NASA and contractor teams are designing, building and testing the next generation human spacecraft Orion. Progress on Orion is highlighted by employees working on the project, along with video of t...

  20. Progressive Supranuclear Palsy

    MedlinePlus

    Progressive supranuclear palsy (PSP) is a rare brain disease. It affects brain cells that control the movement of your eyes. This leads to ... speech, vision and swallowing problems. Doctors sometimes confuse PSP with Parkinson's disease or Alzheimer's disease. PSP has ...

  1. Immunotherapy Slows TNBC Progression.

    PubMed

    2015-06-01

    The experimental monoclonal antibody MPDL3280A extended progression-free survival and produced durable responses in some patients with triple-negative breast cancer, according to preliminary results from a phase I trial.

  2. Identification and characterization of conservative organic tracers for use as hydrologic tracers for the Yucca Mountain site characterization project: Quality Assurance Project Plan, Revision 1; Quarterly progress report, October 1, 1993--December 31, 1993

    SciTech Connect

    Stetzenbach, K.J.

    1993-12-13

    The purpose of this work is to identify and characterize candidate conservative organic tracers for use as hydrologic tracers for experiments to be conducted at the Yucca Mountain C-well complex. During this quarter the main effort was directed towards rewriting the quality assurance program in preparation for a review and audit by the USGS. However, due to budget constraints the review and audit were not carried out. The tracer QA plan and standard operating procedures (SOPs) were revised and copies are included in the report. Instrumental problems were encountered and corrected with the addition of new integration and sample control software. In the sampling, there was an unexplained peak in the chromatograms of the tracers being tested in the light tuff. This was not correctable and these experiments will be repeated in the next quarter.

  3. Progressive supranuclear palsy.

    PubMed

    Kent, Anna

    Progressive supranuclear palsy (PSP), or Steele-Richardson-Olszewski syndrome, is a rare, progressive neurodegenerative condition with cognitive and motor involvement. Diagnosis can be challenging as some people do not display the classic symptoms of the condition and there are no specific investigations to confirm diagnosis. Timely discussions and access to symptom management and palliative care services need to be provided from diagnosis throughout the disease trajectory to ensure holistic care of people with PSP.

  4. Organ Donation

    MedlinePlus

    Organ donation takes healthy organs and tissues from one person for transplantation into another. Experts say that the ... lungs Skin Bone and bone marrow Cornea Most organ and tissue donations occur after the donor has died. But some ...

  5. [Progressive visual agnosia].

    PubMed

    Sugimoto, Azusa; Futamura, Akinori; Kawamura, Mitsuru

    2011-10-01

    Progressive visual agnosia was discovered in the 20th century following the discovery of classical non-progressive visual agnosia. In contrast to the classical type, which is caused by cerebral vascular disease or traumatic injury, progressive visual agnosia is a symptom of neurological degeneration. The condition of progressive visual loss, including visual agnosia, and posterior cerebral atrophy was named posterior cortical atrophy (PCA) by Benson et al. (1988). Progressive visual agnosia is also observed in semantic dementia (SD) and other degenerative diseases, but there is a difference in the subtype of visual agnosia associated with these diseases. Lissauer (1890) classified visual agnosia into apperceptive and associative types, and it in most cases, PCA is associated with the apperceptive type. However, SD patients exhibit symptoms of associative visual agnosia before changing to those of semantic memory disorder. Insights into progressive visual agnosia have helped us understand the visual system and discover how we "perceive" the outer world neuronally, with regard to consciousness. Although PCA is a type of atypical dementia, its diagnosis is important to enable patients to live better lives with appropriate functional support.

  6. Control of the accumulation of non-process elements and organic compounds in pulp mills with bleach filtrate reuse. Milestones and progress, Quarter 8 (April 1--June 30, 1998)

    SciTech Connect

    Frederick, W.J.; Laver, M.L.; Rorrer, G.L.; Rudie, A.W.; Schmidl, W.

    1998-08-01

    Overall, this project is on schedule and proceeding as planned. Two approach changes are recommended. One is to rely on commercially developed software, in particular that developed by OLI Systems, Inc., and now being expanded in a collaborative effort between OLI Systems, Inc. and IPST to provide a simulation package for the pulp and paper industry and to integrate it with existing process simulation tools used by that industry. The second is the development of a detailed brownstock/bleached fiber washer model as a tool to evaluate the data and methods developed in this study, and to demonstrate its utility to industry. Both of these are discussed in more detail in the Approach Changes section of this report. Two tasks are behind schedule. They are Task A-2.3, Measurement of stability constants for wood organics with metal ions (scheduled completion date: 6/98), and Task C-1.2, Estimation of unavailable thermodynamic parameters (scheduled completion date: 12/97). The reasons and expected completion dates for these tasks are discussed in the Performance Variances and Open Items section of this report. All other tasks are either completed, or on or ahead of schedule.

  7. Effects of Tidal Turbine Noise on Fish Task 2.1.3.2: Effects on Aquatic Organisms: Acoustics/Noise - Fiscal Year 2011 - Progress Report - Environmental Effects of Marine and Hydrokinetic Energy

    SciTech Connect

    Halvorsen, Michele B.; Carlson, Thomas J.; Copping, Andrea E.

    2011-09-30

    Naturally spawning stocks of Chinook salmon (Oncorhynchus tshawytscha) that utilize Puget Sound are listed as threatened (http://www.nwr.noaa.gov/ESA-Salmon-Listings/Salmon-Populations/ Chinook/CKPUG.cfm). Plans exist for prototype tidal turbines to be deployed into their habitat. Noise is known to affect fish in many ways, such as causing a threshold shift in auditory sensitivity or tissue damage. The characteristics of noise, its spectra and level, are important factors that influence the potential for the noise to injure fish. For example, the frequency range of the tidal turbine noise includes the audiogram (frequency range of hearing) of most fish. This study (Effects on Aquatic Organisms, Subtask 2.1.3.2: Acoustics) was performed during FY 2011 to determine if noise generated by a 6-m-diameter open-hydro turbine might affect juvenile Chinook salmon hearing or cause barotrauma. After they were exposed to simulated tidal turbine noise, the hearing of juvenile Chinook salmon was measured and necropsies performed to check for tissue damage. Experimental groups were (1) noise exposed, (2) control (the same handling as treatment fish but without exposure to tidal turbine noise), and (3) baseline (never handled). Preliminary results indicate that low levels of tissue damage may have occurred but that there were no effects of noise exposure on the auditory systems of the test fish.

  8. Commission on the Future of Howard Community College, Progress Report 2000.

    ERIC Educational Resources Information Center

    Howard Community Coll., Columbia, MD. Office of Planning and Evaluation.

    Presents the Commission on the Future of Howard Community College's (HCC) (Maryland) progress report 2000. Section 1, "Creating a World Class Learning Organization," presents strategic process and tactical action recommendations. Section 2, "Collaboration with Other Educational Organizations," discusses curricular and…

  9. Voices for America's Children: The Progress and the Promise.

    ERIC Educational Resources Information Center

    Foster, Catherine Crystal

    On the occasion of the fifteenth anniversary of the National Association of Child Advocates (NACA), this report discusses the current status of children, demonstrates the progress in the well-being of children due to the organization's efforts, identifies current challenges for child advocates, and describes the history of the organization.…

  10. Organic photovoltaics

    NASA Astrophysics Data System (ADS)

    Demming, Anna; Krebs, Frederik C.; Chen, Hongzheng

    2013-12-01

    Energy inflation, the constant encouragement to economize on energy consumption and the huge investments in developing alternative energy resources might seem to suggest that there is a global shortage of energy. Far from it, the energy the Sun beams on the Earth each hour is equivalent to a year's supply, even at our increasingly ravenous rate of global energy consumption [1]. But it's not what you have got it's what you do with it. Hence the intense focus on photovoltaic research to find more efficient ways to harness energy from the Sun. Recently much of this research has centred on organic solar cells since they offer simple, low-cost, light-weight and large-area flexible photovoltaic structures. This issue with guest editors Frederik C Krebs and Hongzheng Chen focuses on some of the developments at the frontier of organic photovoltaic technology. Improving the power conversion efficiency of organic photovoltaic systems, while maintaining the inherent material, economic and fabrication benefits, has absorbed a great deal of research attention in recent years. Here significant progress has been made with reports now of organic photovoltaic devices with efficiencies of around 10%. Yet operating effectively across the electromagnetic spectrum remains a challenge. 'The trend is towards engineering low bandgap polymers with a wide optical absorption range and efficient hole/electron transport materials, so that light harvesting in the red and infrared region is enhanced and as much light of the solar spectrum as possible can be converted into an electrical current', explains Mukundan Thelakkat and colleagues in Germany, the US and UK. In this special issue they report on how charge carrier mobility and morphology of the active blend layer in thin film organic solar cells correlate with device parameters [2]. The work contributes to a better understanding of the solar-cell characteristics of polymer:fullerene blends, which form the material basis for some of the most

  11. Establishment of an Institute for Fusion Studies. Technical progress report, November 1, 1994--October 31, 1995

    SciTech Connect

    1995-07-01

    The Institute for Fusion Studies is a national center for theoretical fusion plasma physics research. Its purposes are to (1) conduct research on theoretical questions concerning the achievement of controlled fusion energy by means of magnetic confinement--including both fundamental problems of long-range significance, as well as shorter-term issues; (2) serve as a national and international center for information exchange by hosting exchange visits, conferences, and workshops; and (3) train students and postdoctoral research personnel for the fusion energy program and plasma physics research areas. During FY 1995, a number of significant scientific advances were achieved at the IFS, both in long-range fundamental problems as well as in near-term strategic issues, consistent with the Institute`s mandate. Examples of these achievements include, for example, tokamak edge physics, analytical and computational studies of ion-temperature-gradient-driven turbulent transport, alpha-particle-excited toroidal Alfven eigenmode nonlinear behavior, sophisticated simulations for the Numerical Tokamak Project, and a variety of non-tokamak and non-fusion basic plasma physics applications. Many of these projects were done in collaboration with scientists from other institutions. Research discoveries are briefly described in this report.

  12. Crater-lake Santa Maria del Oro as a Pristine Reference for Persistent Organic Pollutants (POP' s) and Heavy Metals Content in Environmental Investigations in Western Mexico (Project Conacyt-Semarnat 2002-C01-0463, in Progress).

    NASA Astrophysics Data System (ADS)

    Zarate-Del Valle, P. F.; Gomez-Hermosillo, C. M.; Venegas-Garcia, D. J.

    2007-12-01

    Santa Maria del Oro Lake ( SMO) (21.37° N, 104.57° W; 750 m a.s.l.) is a quaternary crater-lake located at western Mexico in the natural border between two geological provinces: the plio-quaternary Trans-Mexican Volcanic Belt and the oligo-miocenic silicic volcanic province Sierra Madre Occidental. SMO, a tropical freshwater lake, is a warm-monomictic lake having a diameter of ca. 2 km and a mean depth at the depocenter of ca. 60 m, where three benthos cores were recovered. Contents of POP' s, total inorganic carbon (TIC), total organic carbon (TOC) and heavy metals were analyzed. Geochemistry and mineralogy also were studied in shallow sediments which corresponded to the decade of 50-60's, otherwise the beginning of industrial development of central Mexico; which is considered the possible source of emission of POP' s and heavy metals. Dioxin, furan, plaguicides and PCB' s contents were analyzed by a GC-MS applying USEPA methods. In the first 40 cm (n= 20) of the sedimentary column ( SC) the absence of POP' s was evidenced, applying a method detection limit ( MDL) of 5 μ g/ml for dioxin, furan and PCB' s. For plaguicides like chlordane and toxaphene the MDL was 0.5 μ g/ml and for plaguicides like DDT, aldrin, endrin, dieldrin, heptachlore and mirex the MDL was 5 μ g/ml. The MDL for HCB was 1 μ g/ml. The average (n= 30) for TIC, TOC and total carbon (TC) for the first 40 cm of the SC is as follows: TIC 2.4 %, TOC 3.7 % and TC 6.12 %. The average (n= 20) content (in ppm) of heavy metals for the first 20 cm of the SC is as follows: As 5.97, Cr 27.54, Cu 16.31, Ni 12.29, Pb 21.35 and Zn 82.46. These contents are roughly similar to the clarke of these metals in volcanic rocks. After the criteria of severe effect level ( SEL) of heavy metal in sediments, the content of these metals is below SEL levels. These results permit us to conclude that the sediments of SMO can be considered in unaffected state with respect to antropogenic contamination like POP' s and heavy

  13. Progressive supranuclear palsy: progression and survival.

    PubMed

    Arena, Julieta E; Weigand, Stephen D; Whitwell, Jennifer L; Hassan, Anhar; Eggers, Scott D; Höglinger, Günter U; Litvan, Irene; Josephs, Keith A

    2016-02-01

    Progressive supranuclear palsy (PSP) is a progressive neurodegenerative disorder characterized by postural instability and falls, vertical supranuclear gaze palsy, parkinsonism with poor levodopa response, pseudobulbar palsy, and frontal release signs. The natural history of the disease has been previously described. However, the time frame of appearance of clinical milestones and how these symptoms may relate to survival in PSP are unknown. The primary objective was to determine the prevalence of symptoms at different stages of PSP and to estimate the time of appearance of clinical symptoms characteristic of the disease. Second, we determined the association between clinical symptoms and survival. We prospectively studied 35 PSP patients during assessments scheduled every 6 months for up to 2 years. We estimated symptoms prevalence and the association between symptoms and survival. The median age of onset was 65.9 years (IQR 60.6-70.0), and the median time from onset to first assessment was 3.0 years (IQR 2.4-3.9). The most commonly reported symptoms at baseline were: motor (100%) followed by cognitive/behavioral (89%), systemic and bulbar (80%), and sleep disturbances (60%). Slowness of movement, falls, neck stiffness and difficulty looking up/down had high prevalence from baseline, while balance and gait impairment were less common at baseline but increased in prevalence over time. The presence of sleep disturbances, and possibly hallucinations, was associated with increased death risk. Improved recognition of the clinical spectrum and milestones of PSP advances knowledge of the disease, helps earlier diagnosis, and allows prognostic predictions.

  14. Genetic progression of malignant melanoma.

    PubMed

    Tímár, J; Vizkeleti, L; Doma, V; Barbai, T; Rásó, E

    2016-03-01

    possible organ-specific metastatic drivers in melanoma. These observations suggest that clinical management of melanoma patients must rely on the genetic analysis of the metastatic lesions to be able to monitor progression-associated changes and to personalize therapies.

  15. Pesticide reregistration progress report

    SciTech Connect

    Not Available

    1993-01-01

    The report is produced by the Special Review and Reregistration Division (SRRD), Office of Pesticide Programs, U.S. Environmental Protection Agency (EPA), on progress towards pesticide reregistration as mandated under 1988 amendments to the Federal Insecticide, Fungicide, and Rodenticide Act. The report shows the status of reregistration through the first quarter of the 1993 fiscal year. SRRD is in the process of re-evaluating the format and information in the Progress Report, as a result of the October 1992 Customer Survey sent to the recipients of the report. Results of the survey will be incorporated in the April 1993 issue of the report.

  16. Annual Progress Report (SEATO Medical Research Laboratory)

    DTIC Science & Technology

    1975-03-01

    Dengue Shock Syndrome ," in Amos, B. (ed): Progress in Immunology, New York, Academic Press, 1971, pp 831 -838. 2. Halstead, S.B. : Observations Related...transmission is primarily genital to oral. The fact that oropharyngeal Infections of N. gonorrhoeae were detected in women visiting a dental clinic on a...causative in 8096 of female genital tract Infections (9). These organisms have also been found in normal vaginal secretiors (10). Therefore, they should

  17. Validating and Optimizing the Effects of Model Progression in Simulation-Based Inquiry Learning

    ERIC Educational Resources Information Center

    Mulder, Yvonne G.; Lazonder, Ard W.; de Jong, Ton; Anjewierden, Anjo; Bollen, Lars

    2012-01-01

    Model progression denotes the organization of the inquiry learning process in successive phases of increasing complexity. This study investigated the effectiveness of model progression in general, and explored the added value of either broadening or narrowing students' possibilities to change model progression phases. Results showed that…

  18. Mystery in Progress.

    ERIC Educational Resources Information Center

    Hall, Kristen

    1989-01-01

    Describes "Mystery in Progress," a traveling exhibit which traces the development of Predynastic Egypt. The exhibit provides a time line for Predynastic Egypt, depicts the history of the Hierakonpolis expedition, documents the formation of Egypt's first centralized nation state, and summarizes the emergence of a unified Egypt. (LS)

  19. [Progress on transgenic mosquitoes].

    PubMed

    Yang, Pin

    2011-04-30

    The genetically modified mosquitoes have been developed aiming to control mosquito-borne diseases by either reducing population sizes or replacing existing populations with vectors unable to transmit the disease. introduces some progress on the generation of transgenic mosquitoes and their fitness in wild population. This paper

  20. 1992 PVUSA progress report

    SciTech Connect

    Ellyn, W.

    1992-12-31

    Photovoltaics for Utility Scale Applications (PVUSA) is a national public-private partnership that is assessing and demonstrating the viability of utility-scale photovoltaic (PV) electric generating systems. This report updates the progress of the PVUSA project, reviews the status and performance of the various PV installations during 1992, and summarizes key accomplishments and conclusions from work to date.

  1. Basic Measures of Progress.

    ERIC Educational Resources Information Center

    Calkins, Julia; Ling, Thomson; Moore, Eric; Halle, Tamara; Hair, Beth; Moore, Kris; Zaslow, Marty

    This document provides a compilation of measures of progress toward school readiness and three contributing conditions as used in several local, state, and national surveys. The report begins with a legend listing the surveys examined, their acronyms, and contact information. The remainder of the report, in tabular format, lists measures of…

  2. MCNP Progress & Performance Improvements

    SciTech Connect

    Brown, Forrest B.; Bull, Jeffrey S.; Rising, Michael Evan

    2015-04-14

    Twenty-eight slides give information about the work of the US DOE/NNSA Nuclear Criticality Safety Program on MCNP6 under the following headings: MCNP6.1.1 Release, with ENDF/B-VII.1; Verification/Validation; User Support & Training; Performance Improvements; and Work in Progress. Whisper methodology will be incorporated into the code, and run speed should be increased.

  3. Learning Progressions & Climate Change

    ERIC Educational Resources Information Center

    Parker, Joyce M.; de los Santos, Elizabeth X.; Anderson, Charles W.

    2015-01-01

    Our society is currently having serious debates about sources of energy and global climate change. But do students (and the public) have the requisite knowledge to engage these issues as informed citizenry? The learning-progression research summarized here indicates that only 10% of high school students typically have a level of understanding…

  4. Progress in physiological optics.

    PubMed

    Boynton, R M

    1967-08-01

    A survey is made of the current state of physiological optics, broadly defined as equated with visual science. After a survey of some historical and definitional matters, recent progress in a number of areas is critically reviewed. Finally, seven examples of important recent discoveries in physiological optics are given.

  5. Opportunities and progress.

    PubMed

    Litchfield, John H

    2014-01-01

    In this review, I cover my professional experiences in food science and technology and related areas of applied and industrial microbiology over the span of my career. It emphasizes opportunities and technological problems that I encountered together with my progress in follow-up development of products and processes.

  6. Site specific plan. [Environmental Restoration and Waste Management, Savannah River Site

    SciTech Connect

    Hutchison, J.; Jernigan, G.

    1989-12-01

    The Environmental Restoration and Waste Management Five-Year Plan (FYP) covers the period for FY 1989 through FY 1995. The plan establishes a Department of Energy -- Headquarters (DOE-HQ) agenda for cleanup and compliance against which overall progress can be measured. The FYP covers three areas: Corrective Activities, Environmental Restoration, and Waste Management Operations. Corrective Activities are those activities necessary to bring active or standby facilities into compliance with local, state, and federal environmental regulations. Environmental restoration activities include the assessment and cleanup of surplus facilities and inactive waste sites. Waste management operations includes the treatment, storage, and disposal of wastes which are generated as a result of ongoing operations. This Site Specific Plan (SSP) has been prepared by the Savannah River Site (SRS) in order to show how environmental restoration and waste management activities that were identified during the preparation of the FYP will be implemented, tracked, and reported. The SSP describes DOE Savannah River (DOE-SR) and operating contractor, Westinghouse Savannah River Company (WSRC), organizations that are responsible, for undertaking the activities identified in this plan. The SSP has been prepared in accordance with guidance received from DOE-HQ. DOE-SR is accountable to DOE-HQ for the implementation of this plan. 8 refs., 46 figs., 23 tabs.

  7. Progressive Response Surfaces

    NASA Technical Reports Server (NTRS)

    Romero, V. J.; Swiler, L. P.

    2004-01-01

    Response surface functions are often used as simple and inexpensive replacements for computationally expensive computer models that simulate the behavior of a complex system over some parameter space. Progressive response surfaces are ones that are built up progressively as global information is added from new sample points in the parameter space. As the response surfaces are globally upgraded based on new information, heuristic indications of the convergence of the response surface approximation to the exact (fitted) function can be inferred. Sampling points can be incrementally added in a structured fashion, or in an unstructured fashion. Whatever the approach, at least in early stages of sampling it is usually desirable to sample the entire parameter space uniformly. At later stages of sampling, depending on the nature of the quantity being resolved, it may be desirable to continue sampling uniformly over the entire parameter space (Progressive response surfaces), or to switch to a focusing/economizing strategy of preferentially sampling certain regions of the parameter space based on information gained in early stages of sampling (Adaptive response surfaces). Here we consider Progressive response surfaces where a balanced indication of global response over the parameter space is desired.We use a variant of Moving Least Squares to fit and interpolate structured and unstructured point sets over the parameter space. On a 2-D test problem we compare response surface accuracy for three incremental sampling methods: Progressive Lattice Sampling; Simple-Random Monte Carlo; and Halton Quasi-Monte-Carlo sequences. We are ultimately after a system for constructing efficiently upgradable response surface approximations with reliable error estimates.

  8. Photochromic transduction layers in organic memory elements.

    PubMed

    Shallcross, R Clayton; Zacharias, Philipp; Köhnen, Anne; Körner, Peter O; Maibach, Eduard; Meerholz, Klaus

    2013-01-18

    Photochromic molecules provide an intriguing and relatively untapped alternative to traditional materials utilized in organic memory devices. Here, we review recent progress in the implementation of photochromic molecules in electrically-addressed organic memory devices. Recent results for a lightemitting photochromic organic diode are highlighted in the context of multifunctional devices with the ability to simultaneously operate as multilevel memory, signage and display elements. Furthermore, a set of design rules for successful implementation of photochromic compounds in organic memory devices are suggested.

  9. Graphic Representation of Organs and Organ Systems: Psychological View and Developmental Patterns

    ERIC Educational Resources Information Center

    Bartoszeck, Amauri Betini; Machado, Danielle Zagonel; Amann-Gainotti, Merete

    2011-01-01

    The objective of this exploratory study is to characterize by means of drawings if the developmental patterns in the graphic representation of organ and organ systems progresses related to age of participants. Secondly, whether there is an integration of sex organs into the internal body image. The drawings representing the inside of the body in…

  10. The Progressive Era.

    PubMed

    Chambers, David W

    2005-01-01

    The American College of Dentists was founded in 1920 for the purpose of encouraging young dentists to continue study and to apply science to their practices. This ideal emerged in the Progressive Era, which lasted roughly from 1895 to 1920. The animating spirit of this period was that the human condition could be improved and that the way to achieve this was through science and the use of experts working together. The Progressive Era saw inventions, such as automobiles and airplanes, telephone and radio, that required mass production and brought people together. It also spawned many political and legislative innovations that we now take for granted. Among these are the Food and Drug Administration, the Department of Commerce, and the Federal Trade Commission. Workers' compensation and other social protections were introduced, as were city commissions; the income tax; women's suffrage; and initiative, referendum, and recall. Medicine, for the first time, became an effective way to treat disease as it developed a scientific foundation.

  11. Progress In Holographic Cinematography

    NASA Astrophysics Data System (ADS)

    Smigielski, P.; Fagot, H.; Albe, F.

    1986-06-01

    Two important progresses were achieved for the first time: 1) recording of single exposure cineholograms of living bodies on a 126-mm film, at a frequency of 25 holograms per second. Limitations of 3-D movies by holography are described. 2) recording of double-exposure cineholograms of reflecting objects, a loudspeaker membrane and the vertex cranii of a bald-headed man. These experiments show the interest of interferometric cineholography for industrial applications.

  12. Xenon Feed System Progress

    DTIC Science & Technology

    2006-01-01

    From - To) 13-06-2006 Technical Paper 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER F04611-00-C-0055 Xenon Feed System Progress (Preprint) 5b. GRANT...propulsion xenon feed system for a flight technology demonstration program. Major accomplishments include: 1) Utilization of the Moog...successfully fed xenon to a 200 watt Hall Effect Thruster in a Technology Demonstration Program. The feed system has demonstrated throttling of xenon

  13. COSMIC monthly progress report

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Activities of the Computer Software Management and Information Center (COSMIC) are summarized for the month of January 1994. Tables showing the current inventory of programs available from COSMIC are presented and program processing and evaluation activities are discussed. Marketing and customer service activities in this period are presented as is the progress report of NASTRAN maintenance and support. Tables of disseminations and budget summary conclude the report.

  14. ISABELLE: a progress report

    SciTech Connect

    Hahn, H

    1980-01-01

    This paper discusses the ISABELLE project, which has the objective of constructing a high-energy proton colliding beam facility at Brookhaven National Laboratory. The major technical features of the intersecting storage accelerators with their projected performance are described. Application of over 1000 superconducting magnets in the two rings represents the salient characteristic of the machine. The status of the entire project, the technical progress made so far, and difficulties encountered are reviewed.

  15. [Progress in optical imaging].

    PubMed

    Bremer, C; Ntziachristos, V; Mahmood, U; Tung, C H; Weissleder, R

    2001-02-01

    Different optical imaging technologies have significantly progressed over the last years. Besides advances in imaging techniques and image reconstruction, new "smart" optical contrast agents have been developed which can be used to detect molecular targets (such as endogenous enzymes) in vivo. The combination of novel imaging technologies coupled with smart agents bears great diagnostic potential both clinically and experimentally. This overview outlines the basic principles of optical imaging and summarizes the current state of the art.

  16. Progress in Scientific Visualization

    SciTech Connect

    Max, N

    2004-11-15

    Visualization of observed data or simulation output is important to science and engineering. I have been particularly interested in visualizing 3-D structures, and report here my personal impressions on progress in the last 20 years in visualizing molecules, scalar fields, and vector fields and their associated flows. I have tried to keep the survey and list of references manageable, so apologize to those authors whose techniques I have not mentioned, or have described without a reference citation.

  17. Topiramate in migraine progression.

    PubMed

    Ruiz, Luigi; Ferrandi, Delfina

    2009-12-01

    Increasing evidence shows that migraine, typically considered as an episodic disease, is a chronic and, in some patients, progressive disorder. Among neuromodulators used for migraine prevention, topiramate has a high level of evidence-based efficacy. Through its wide range of mechanisms of action topiramate increases the activation threshold resulting in neuronal stabilization and thereby reducing cortical neurons hyperexcitability, which is believed to be an important electrophysiological feature underlying the pathogenesis of epilepsy and migraine. Recent studies show that migraineurs have subclinical structural brain changes and persistent alteration of pain perception, in some cases correlated with the duration of the disease and the frequency of attacks that might play a role in the transformation of episodic migraine to chronic forms. An early and prolonged preventive treatment might reduce the risk of such transformation. Recent evidence suggests that topiramate, by reducing migraine frequency and use of acute medication, may prevent the negative progression of migraine. Furthermore, two recently completed multicenter, randomised, placebo-controlled trials have shown that treatment with topiramate 100 mg/day is effective and well tolerated in patients already progressed to chronic migraine and difficult to treat conditions associated with medication-overuse. Topiramate seems to be a preventive treatment, which might be able to act at different levels of the migraine cycle: reduction of frequency in episodic migraine, prevention, and treatment of chronic migraine.

  18. Let s make progress together!

    NASA Astrophysics Data System (ADS)

    Adriana, Mazare; Liliana, Gheorghian

    2015-04-01

    Let's make progress together! The "Theodor Balan" Secondary School in the urban area of Suceava County in northeastern Romania is involved in several different projects. In order to extend previous successful projects with the students, parents, teachers, businesses and local government representatives in science symposiums for civic projects within the concept of sustainable development, the school is continuing to develop various successful programs. "The battle" continues both in nature and in the classrooms, in order to preserve the environment and to discover new resources. To raise awareness about the importance of existing resources even at the level of individuals there is a constant concern for keeping up to date on what already exists and is well known, but at the same time to remove "barriers" and discover new horizons and resources. Scientific activities held in our school are an effective way to educate students and the community to which they belong. In our community, we discovered sources of drinking water polluted by nitrites from fertilizers used in agriculture. In order to inform and educate people in the area, our teachers have organized several educational activities. Its purpose was: -Knowledge of the importance of water for the environment and human health. -Reducing water pollution. Students have informed their families' about sustainable development acquired at school. In this way, the school manages to educate and change people's ideas. The ways and methods of adults' learning were practiced within a Grundtvig training course "It's never too late learning to learn" in February 2014, in Florence, Italy. The GIFT 2014 was a great occasion for the teachers and students, the county's educational department and the participants at the National Colloquia of Physics to discover new materials provided at the Conference and the latest news and topics in the world of science. The theme trips at the physics laboratories of "Alexandru Ioan Cuza

  19. Memory T cells in organ transplantation: progress and challenges

    PubMed Central

    Espinosa, Jaclyn R.; Samy, Kannan P.; Kirk, Allan D.

    2017-01-01

    Antigen-experienced T cells, also known as memory T cells, are functionally and phenotypically distinct from naive T cells. Their enhanced expression of adhesion molecules and reduced requirement for co-stimulation enables them to mount potent and rapid recall responses to subsequent antigen encounters. Memory T cells generated in response to prior antigen exposures can cross-react with other nonidentical, but similar, antigens. This heterologous cross-reactivity not only enhances protective immune responses, but also engenders de novo alloimmunity. This latter characteristic is increasingly recognized as a potential barrier to allograft acceptance that is worthy of immunotherapeutic intervention, and several approaches have been investigated. Calcineurin inhibition effectively controls memory T-cell responses to allografts, but this benefit comes at the expense of increased infectious morbidity. Lymphocyte depletion eliminates allospecific T cells but spares memory T cells to some extent, such that patients do not completely lose protective immunity. Co-stimulation blockade is associated with reduced adverse-effect profiles and improved graft function relative to calcineurin inhibition, but lacks efficacy in controlling memory T-cell responses. Targeting the adhesion molecules that are upregulated on memory T cells might offer additional means to control co-stimulation-blockade-resistant memory T-cell responses. PMID:26923209

  20. Rapidly Progressing Alzheimer's: Something Else?

    MedlinePlus

    ... speed of progression varies, depending on a person's genetic makeup, environmental factors, age at diagnosis and other medical conditions. Still, anyone diagnosed with Alzheimer's whose symptoms seem to be progressing quickly — or ...

  1. Carbon nanotube electrodes in organic transistors.

    PubMed

    Valitova, Irina; Amato, Michele; Mahvash, Farzaneh; Cantele, Giovanni; Maffucci, Antonio; Santato, Clara; Martel, Richard; Cicoira, Fabio

    2013-06-07

    The scope of this Minireview is to provide an overview of the recent progress on carbon nanotube electrodes applied to organic thin film transistors. After an introduction on the general aspects of the charge injection processes at various electrode-semiconductor interfaces, we discuss the great potential of carbon nanotube electrodes for organic thin film transistors and the recent achievements in the field.

  2. Progressive image denoising.

    PubMed

    Knaus, Claude; Zwicker, Matthias

    2014-07-01

    Image denoising continues to be an active research topic. Although state-of-the-art denoising methods are numerically impressive and approch theoretical limits, they suffer from visible artifacts.While they produce acceptable results for natural images, human eyes are less forgiving when viewing synthetic images. At the same time, current methods are becoming more complex, making analysis, and implementation difficult. We propose image denoising as a simple physical process, which progressively reduces noise by deterministic annealing. The results of our implementation are numerically and visually excellent. We further demonstrate that our method is particularly suited for synthetic images. Finally, we offer a new perspective on image denoising using robust estimators.

  3. Post Kalman progress

    NASA Technical Reports Server (NTRS)

    Sonnabend, David

    1995-01-01

    In a paper here last year, an idea was put forward that much greater performance could be obtained from an observer, relative to a Kalman filter if more general performance indices were adopted, and the full power spectra of all the noises were employed. The considerable progress since then is reported here. Included are an extension of the theory to regulators, direct calculation of the theory's fundamental quantities - the noise effect integrals - for several theoretical spectra, and direct derivations of the Riccati equations of LQG (Linear-Quadratic-Gaussian) and Kalman theory yielding new insights.

  4. [Progress in eyeglass optics].

    PubMed

    Köppen, W

    1995-08-01

    In this article product developments for ophthalmic lenses are discussed: new materials, designs and coatings. High-index plastic substrates allow to offer corrections which are simultaneously light and thin and for the first time there are high performant plastic photochromic lenses. Head and eye movements with latest generation's progressives are very similar to natural vision behaviour. Special aspheric designs have been developed for comfortable vision for near and intermediate distances. Finally there are new coatings which protect the high quality surfaces of plastic lenses distinctly longer than before.

  5. MEIC Design Progress

    SciTech Connect

    Zhang, Y; Douglas, D; Hutton, A; Krafft, G A; Li, R; Lin, F; Morozov, V S; Nissen, E W; Pilat, F C; Satogata, T; Tennant, C; Terzic, B; Yunn, C; Barber, D P; Filatov, Y; Hyde, C; Kondratenko, A M; Manikonda, S L; Ostroumov, P N; Sullivan, M K

    2012-07-01

    This paper will report the recent progress in the conceptual design of MEIC, a high luminosity medium energy polarized ring-ring electron-ion collider at Jefferson lab. The topics and achievements that will be covered are design of the ion large booster and the ERL-circulator-ring-based electron cooling facility, optimization of chromatic corrections and dynamic aperture studies, schemes and tracking simulations of lepton and ion polarization in the figure-8 collider ring, and the beam-beam and electron cooling simulations. A proposal of a test facility for the MEIC electron cooler will also be discussed.

  6. HSX progress report

    SciTech Connect

    Not Available

    1994-05-01

    Brief statements on the progress of the design and construction of the HSX experiment are reported. Topics covered include the modular and auxiliary coil systems, the coil support structure, vacuum vessel, the ECH system, the magnet power supply and site. The proposed budget for Year 2 (August 1, 1994 through July 31, 1995) is presented. The effects of a flat funding profile (based on Year 2 budget level of $1137K) on out-years and the HSX project schedule are discussed. The stretching out of the program to accommodate the reduced funding profile should result in only a slight delay in HSX operations.

  7. Recent Progress in Electronic Skin.

    PubMed

    Wang, Xiandi; Dong, Lin; Zhang, Hanlu; Yu, Ruomeng; Pan, Caofeng; Wang, Zhong Lin

    2015-10-01

    The skin is the largest organ of the human body and can sense pressure, temperature, and other complex environmental stimuli or conditions. The mimicry of human skin's sensory ability via electronics is a topic of innovative research that could find broad applications in robotics, artificial intelligence, and human-machine interfaces, all of which promote the development of electronic skin (e-skin). To imitate tactile sensing via e-skins, flexible and stretchable pressure sensor arrays are constructed based on different transduction mechanisms and structural designs. These arrays can map pressure with high resolution and rapid response beyond that of human perception. Multi-modal force sensing, temperature, and humidity detection, as well as self-healing abilities are also exploited for multi-functional e-skins. Other recent progress in this field includes the integration with high-density flexible circuits for signal processing, the combination with wireless technology for convenient sensing and energy/data transfer, and the development of self-powered e-skins. Future opportunities lie in the fabrication of highly intelligent e-skins that can sense and respond to variations in the external environment. The rapidly increasing innovations in this area will be important to the scientific community and to the future of human life.

  8. Recent Progress in Electronic Skin

    PubMed Central

    Wang, Xiandi; Dong, Lin; Zhang, Hanlu; Yu, Ruomeng; Wang, Zhong Lin

    2015-01-01

    The skin is the largest organ of the human body and can sense pressure, temperature, and other complex environmental stimuli or conditions. The mimicry of human skin's sensory ability via electronics is a topic of innovative research that could find broad applications in robotics, artificial intelligence, and human–machine interfaces, all of which promote the development of electronic skin (e‐skin). To imitate tactile sensing via e‐skins, flexible and stretchable pressure sensor arrays are constructed based on different transduction mechanisms and structural designs. These arrays can map pressure with high resolution and rapid response beyond that of human perception. Multi‐modal force sensing, temperature, and humidity detection, as well as self‐healing abilities are also exploited for multi‐functional e‐skins. Other recent progress in this field includes the integration with high‐density flexible circuits for signal processing, the combination with wireless technology for convenient sensing and energy/data transfer, and the development of self‐powered e‐skins. Future opportunities lie in the fabrication of highly intelligent e‐skins that can sense and respond to variations in the external environment. The rapidly increasing innovations in this area will be important to the scientific community and to the future of human life. PMID:27980911

  9. Peptide Vaccine: Progress and Challenges

    PubMed Central

    Li, Weidang; Joshi, Medha D.; Singhania, Smita; Ramsey, Kyle H.; Murthy, Ashlesh K.

    2014-01-01

    Conventional vaccine strategies have been highly efficacious for several decades in reducing mortality and morbidity due to infectious diseases. The bane of conventional vaccines, such as those that include whole organisms or large proteins, appear to be the inclusion of unnecessary antigenic load that, not only contributes little to the protective immune response, but complicates the situation by inducing allergenic and/or reactogenic responses. Peptide vaccines are an attractive alternative strategy that relies on usage of short peptide fragments to engineer the induction of highly targeted immune responses, consequently avoiding allergenic and/or reactogenic sequences. Conversely, peptide vaccines used in isolation are often weakly immunogenic and require particulate carriers for delivery and adjuvanting. In this article, we discuss the specific advantages and considerations in targeted induction of immune responses by peptide vaccines and progresses in the development of such vaccines against various diseases. Additionally, we also discuss the development of particulate carrier strategies and the inherent challenges with regard to safety when combining such technologies with peptide vaccines. PMID:26344743

  10. A progressive-duration schedule of reinforcement.

    PubMed

    Gulotta, Kara B; Byrne, Tom

    2015-12-01

    We describe a schedule of reinforcement involving systematic, within-session increases in response-duration requirements. Rats received access to appetitive reinforcers for depressing and holding down a response lever. Duration requirements increased after each reinforcer delivery. Sessions ended when reinforcement criteria were unmet for a period of ten minutes. Breaking points, defined as the terminal duration requirement in effect prior to the end of the session, stabilized when environmental conditions were held constant. Breaking points were sensitive to manipulations of both food deprivation and reinforcer quality. Analogous to progressive-ratio schedules, progressive-duration schedules may provide an assay for measuring the amount of behavior an organism will emit for a given reinforcer under current motivational conditions.

  11. Organic Magnetoresistance

    NASA Astrophysics Data System (ADS)

    Epstein, Arthur

    2009-03-01

    In recent years a broad range of magnetoresistance phenomena have been reported for organic-based semiconductors, conductors and magnets. Organic systems illustrating magnetoresistance, include molecular- and polymer-based nonmagnetic semiconductors[1], organic-based spin polarized magnetic semiconductors,[2] nonmagnetic conducting polymers, and ferromagnet/organic semiconductor/ferromagnet heterojunctions. Examples of each of these organic-based systems will be presented together with a discussion of the roles of magnetotransport mechanisms including interconversion of singlets and triplets, compression of the electronic wavefunction in presence of a magnetic field, quantum interference phenomena, effects of a ``Coulomb gap'' in π* subbands of organic magnetic semiconductors with resulting near complete spin polarization in conduction and valence bands of magnetic organic semiconductors.[2,3] Opportunities for magnetotransport in Ferromagnet/Organic Semiconductor/Ferromagnet heterojunctions will be discussed.[4] [4pt] [1] V.N. Prigodin et al., Synth. Met. 156, 757 (2006); J.D. Bergeson et al., Phys. Rev. Lett. 100, 067201 (2008) [0pt] [2] V.N. Prigodin et al., Adv. Mater. 14, 1230 (2002. [0pt] [3] J.B. Kortright et al., Phys. Rev. Lett., 100, 257204 (2008). [0pt] [4] J.D. Bergeson, et al., Appl. Phys. Lett. 93, 172505 (2008).

  12. Conceptions of Progress: How Is Progress Perceived? Mainstream versus Alternative Conceptions of Progress

    ERIC Educational Resources Information Center

    Itay, Anat

    2009-01-01

    Progress is a powerful political concept, encompassing different and sometimes contradictory conceptions. This paper examines the results of a survey on progress conducted at the OECD World Forum entitled "Measuring and Fostering the Progress of Societies" held in Istanbul in June 2007. First, a distinction is drawn between the two approaches to…

  13. Organic aerosols

    SciTech Connect

    Penner, J.E.

    1994-01-01

    Organic aerosols scatter solar radiation. They may also either enhance or decrease concentrations of cloud condensation nuclei. This paper summarizes observed concentrations of aerosols in remote continental and marine locations and provides estimates for the sources of organic aerosol matter. The anthropogenic sources of organic aerosols may be as large as the anthropogenic sources of sulfate aerosols, implying a similar magnitude of direct forcing of climate. The source estimates are highly uncertain and subject to revision in the future. A slow secondary source of organic aerosols of unknown origin may contribute to the observed oceanic concentrations. The role of organic aerosols acting as cloud condensation nuclei (CCN) is described and it is concluded that they may either enhance or decrease the ability of anthropogenic sulfate aerosols to act as CCN.

  14. Rapidly Progressive Dementia

    PubMed Central

    Geschwind, Michael D.

    2016-01-01

    Purpose of Review This article presents a practical and informative approach to the evaluation of a patient with a rapidly progressive dementia (RPD). Recent Findings Prion diseases are the prototypical causes of RPD, but reversible causes of RPD might mimic prion disease and should always be considered in a differential diagnosis. Aside from prion diseases, the most common causes of RPD are atypical presentations of other neurodegenerative disorders, curable disorders including autoimmune encephalopathies, as well as some infections, and neoplasms. Numerous recent case reports suggest dural arterial venous fistulas sometimes cause RPDs. Summary RPDs, in which patients typically develop dementia over weeks to months, require an alternative differential than the slowly progressive dementias that occur over a few years. Because of their rapid decline, patients with RPDs necessitate urgent evaluation and often require an extensive workup, typically with multiple tests being sent or performed concurrently. Jakob-Creutzfeldt disease, perhaps the prototypical RPD, is often the first diagnosis many neurologists consider when treating a patient with rapid cognitive decline. Many conditions other than prion disease, however, including numerous reversible or curable conditions, can present as an RPD. This chapter discusses some of the major etiologies for RPDs and offers an algorithm for diagnosis. PMID:27042906

  15. Tumour progression and metastasis

    PubMed Central

    Arvelo, Francisco; Sojo, Felipe; Cotte, Carlos

    2016-01-01

    The two biological mechanisms that determine types of malignancy are infiltration and metastasis, for which tumour microenvironment plays a key role in developing and establishing the morphology, growth and invasiveness of a malignancy. The microenvironment is formed by complex tissue containing the extracellular matrix, tumour and non-tumour cells, a signalling network of cytokines, chemokines, growth factors, and proteases that control autocrine and paracrine communication among individual cells, facilitating tumour progression. During the development of the primary tumour, the tumour stroma and continuous genetic changes within the cells makes it possible for them to migrate, having to count on a pre-metastatic niche receptor that allows the tumour’s survival and distant growth. These niches are induced by factors produced by the primary tumour; if it is eradicated, the active niches become responsible for activating the latent disseminated cells. Due to the importance of these mechanisms, the strategies that develop tumour cells during tumour progression and the way in which the microenvironment influences the formation of metastasis are reviewed. It also suggests that the metastatic niche can be an ideal target for new treatments that make controlling metastasis possible. PMID:26913068

  16. Progressive supranuclear palsy.

    PubMed

    Golbe, Lawrence I

    2014-04-01

    Progressive supranuclear palsy is a disorder of tau protein aggregation. Its clinical spectrum is now known to be wider than originally described, with a phenotype resembling Parkinson disease accounting for a third of cases. However, at least half of the patients with PSP exhibit the classic bradykinesia with disproportionate postural instability, erect posture with nuchal rigidity, frontal behavioral and cognitive changes, vertical gaze palsy, and other disabling brainstem deficits. Nonmendelian genetic risk factors exist, but PSP is almost entirely sporadic, with a prevalence of five to six persons per 100,000, mean onset age of 63, and median survival of 7 years. Clinical diagnostic criteria with excellent specificity and a clinical rating scale sensitive to progression are available. Diagnosis remains clinical, although magnetic resonance imaging and cerebrospinal fluid measures are showing promise as early-stage screening tools. Multiple candidate neuroprotective medications have proven ineffective to date. Treatment remains supportive, although coenzyme Q-10 has shown preliminary symptomatic efficacy and levodopa may provide transient, modest benefit.

  17. [Progressive facial hemiatrophy].

    PubMed

    Naumbaev, A N; Sharipov, A Sh; Iakhontov, B V

    1991-01-01

    The authors describe a case of progressive facial hemiatrophy in a woman aged 26 years, coming from the Isfarin region of Tadzhikistan. The patient views herself as being ill for 14 years, since the moment of an epileptic attack with tonic and clonic convulsions. Approximately at the same time she noted a small dry ulcer on the left on the vertex. The ulcer slowly increased, followed by skin atrophy. The disease progressed for 4 to 5 years. At present to the left there are folds in the form of scars on the face. The skin is thinned, united with the bones in the frontal and parietal areas, the subcutaneous fat is atrophic. The lips and nose at the left are subatrophic. Negligible enophthalmos, hemiatrophy of the tongue at the left. Alopecia. A certain deterioration of memory and reduction of the critical attitude are recorded. The patient is in a state of euphoria. Left-sided anosmia. The left auricular floor is subatrophic, hearing is almost lacking. Diffuse elevation of the tendinous reflexes of the limbs on the left side. X-ray signs of osteoporosis of the bones of the cranial vault on the left.

  18. Progress in Finnish Librarianship

    ERIC Educational Resources Information Center

    Tooley, J. B.

    1971-01-01

    The whole pattern of the library profession is changing and developing in a country which is itself being transformed into a highly sophisticated modern state. Education for librarianship is being re-thought and efforts are being directed towards more cohesive professional organization. (Author/NH)

  19. Progress in string theory

    NASA Astrophysics Data System (ADS)

    Maldacena, Juan Martín

    D-Branes on Calabi-Yau manifolds / Paul S. Aspinwall -- Lectures on AdS/CFT / Juan M. Maldacena -- Tachyon dynamics in open string theory / Ashoke Sen -- TASI/PITP/ISS lectures on moduli and microphysics / Eva Silverstein -- The duality cascade / Matthew J. Strassler -- Perturbative computations in string field theory / Washington Taylor -- Student seminars -- Student participants -- Lecturers, directors, and local organizing committee.

  20. From Pressure to Progress

    ERIC Educational Resources Information Center

    Kashner, Zoe

    2010-01-01

    Corporate workers know what it means when cost-cutting consultants come to the office. Jobs will be eliminated. Employees who remain may have to do more work with less help. And new processes will reshape the organization, often from top to bottom. Although it can be an intensely disturbing event, bringing in consultants is not an exercise in…

  1. Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures Perspectives

    PubMed Central

    Mendoza, Fabian A.; Mansoor, Maryah; Jimenez, Sergio A.

    2016-01-01

    Introduction Systemic Sclerosis (SSc) is a systemic autoimmune disease characterized by severe and often progressive cutaneous, pulmonary, cardiac and gastrointestinal tract fibrosis, cellular and humoral immunologic alterations, and pronounced fibroproliferative vasculopathy. There is no effective SSc disease modifying therapy. Patients with rapidly progressive SSc have poor prognosis with frequent disability and very high mortality. Areas Covered This paper reviews currently available therapeutic approaches for rapidly progressive SSc and discuss novel drugs under study for SSc disease modification. Expert Opinion The extent, severity, and rate of progression of SSc skin and internal organ involvement determines the optimal therapeutic interventions for SSc. Cyclophosphamide for progressive SSc-associated interstitial lung disease and mycophenolate for rapidly progressive cutaneous involvement have shown effectiveness. Methotrexate has been used for less severe skin progression and for patients unable to tolerate mycophenolate. Rituximab was shown to induce improvement in SSc-cutaneous and lung involvement. Autologous bone marrow transplantation is reserved for selected cases in whom poor survival risk outweighs the high mortality rate of the procedure. Novel agents capable of modulating fibrotic and inflammatory pathways involved in SSc pathogenesis, including tocilizumab, pirfenidone, tyrosine kinase inhibitors, lipid lysophosphatidic acid 1, and NOX4 inhibitors are currently under development for the treatment of rapidly progressive SSc. PMID:27812432

  2. Hydrothermal organic synthesis experiments

    NASA Technical Reports Server (NTRS)

    Shock, Everett L.

    1992-01-01

    The serious scientific debate about spontaneous generation which raged for centuries reached a climax in the nineteenth century with the work of Spallanzani, Schwann, Tyndall, and Pasteur. These investigators demonstrated that spontaneous generation from dead organic matter does not occur. Although no aspects of these experiments addressed the issue of whether organic compounds could be synthesized abiotically, the impact of the experiments was great enough to cause many investigators to assume that life and its organic compounds were somehow fundamentally different than inorganic compounds. Meanwhile, other nineteenth-century investigators were showing that organic compounds could indeed be synthesized from inorganic compounds. In 1828 Friedrich Wohler synthesized urea in an attempt to form ammonium cyanate by heating a solution containing ammonia and cyanic acid. This experiment is generally recognized to be the first to bridge the artificial gap between organic and inorganic chemistry, but it also showed the usefulness of heat in organic synthesis. Not only does an increase in temperature enhance the rate of urea synthesis, but Walker and Hambly showed that equilibrium between urea and ammonium cyanate was attainable and reversible at 100 C. Wohler's synthesis of urea, and subsequent syntheses of organic compounds from inorganic compounds over the next several decades dealt serious blows to the 'vital force' concept which held that: (1) organic compounds owe their formation to the action of a special force in living organisms; and (2) forces which determine the behavior of inorganic compounds play no part in living systems. Nevertheless, such progress was overshadowed by Pasteur's refutation of spontaneous generation which nearly extinguished experimental investigations into the origins of life for several decades. Vitalism was dealt a deadly blow in the 1950's with Miller's famous spark-discharge experiments which were undertaken in the framework of the Oparin

  3. Organic spintronics.

    PubMed

    Bergenti, I; Dediu, V; Prezioso, M; Riminucci, A

    2011-08-13

    Organic semiconductors are emerging materials in the field of spintronics. Successful achievements include their use as a tunnel barrier in magnetoresistive tunnelling devices and as a medium for spin-polarized current in transport devices. In this paper, we give an overview of the basic concepts of spin transport in organic semiconductors and present the results obtained in the field, highlighting the open questions that have to be addressed in order to improve devices performance and reproducibility. The most challenging perspectives will be discussed and a possible evolution of organic spin devices featuring multi-functional operation is presented.

  4. Rapidly progressive glomerulonephritis after immunotherapy for cancer.

    PubMed

    Parker, M G; Atkins, M B; Ucci, A A; Levey, A S

    1995-04-01

    Cytokines have been used in experimental and standard protocols for immune enhancement for cancer. The combination of interleukin-2 and interferon-alpha 2 beta has been used in experimental protocols for metastatic renal cell carcinoma. A man who developed rapidly progressive renal failure after receiving this combination therapy is reported. A renal biopsy revealed a pauci-immune crescentic glomerulonephritis. Antineutrophil cytoplasmic antibodies and antiglomerular basement membrane antibodies were absent. The spectrum of renal disease and potentially related extrarenal manifestations associated with interleukin-2 and inteferon-alpha are reviewed. A pathogenesis of altered cell-mediated immunity, consistent with abnormalities in extrarenal organs after immune enhancement, is proposed.

  5. 1992 PVUSA progress report

    SciTech Connect

    1992-12-31

    Photovoltaics for Utility Scale Applications (PVUSA) is a national public-private partnership that is assessing and demonstrating the viability of utility-scale photovoltaic (PV) electric generating systems. This report updates the progress of the PVUSA project, reviews the status and performance of the various PV installations during 1992, and summarizes key accomplishments and conclusions from work to date. Fall PV module costs and rising environmental pressures could make PV a significant source of large-scale power within the next decade. However, utility acceptance of this technology requires knowledge of PV operational characteristics in a utility system and confidence in predicting PV performance, reliability, and economics. PVUSA consists of two types of demonstrations: Emerging Module Technologies (EMTs), which are unproven but promising state-of-the-art PV technologies in 20-kW (nominal) arrays; and Utility Scale (US) systems, which represent more mature PV technologies in 200- to 500-kW (nominal) turnkey systems.

  6. Progressive Band Selection

    NASA Technical Reports Server (NTRS)

    Fisher, Kevin; Chang, Chein-I

    2009-01-01

    Progressive band selection (PBS) reduces spectral redundancy without significant loss of information, thereby reducing hyperspectral image data volume and processing time. Used onboard a spacecraft, it can also reduce image downlink time. PBS prioritizes an image's spectral bands according to priority scores that measure their significance to a specific application. Then it uses one of three methods to select an appropriate number of the most useful bands. Key challenges for PBS include selecting an appropriate criterion to generate band priority scores, and determining how many bands should be retained in the reduced image. The image's Virtual Dimensionality (VD), once computed, is a reasonable estimate of the latter. We describe the major design details of PBS and test PBS in a land classification experiment.

  7. Progressing batch hydrolysis process

    DOEpatents

    Wright, J.D.

    1985-01-10

    A progressive batch hydrolysis process is disclosed for producing sugar from a lignocellulosic feedstock. It comprises passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with feed stock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feed stock to glucose. The cooled dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, serially fed through a plurality of pre-hydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose. The dilute acid stream containing glucose is cooled after it exits the last prehydrolysis reactor.

  8. Progressing batch hydrolysis process

    DOEpatents

    Wright, John D.

    1986-01-01

    A progressive batch hydrolysis process for producing sugar from a lignocellulosic feedstock, comprising passing a stream of dilute acid serially through a plurality of percolation hydrolysis reactors charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the cellulose component of the feedstock to glucose; cooling said dilute acid stream containing glucose, after exiting the last percolation hydrolysis reactor, then feeding said dilute acid stream serially through a plurality of prehydrolysis percolation reactors, charged with said feedstock, at a flow rate, temperature and pressure sufficient to substantially convert all the hemicellulose component of said feedstock to glucose; and cooling the dilute acid stream containing glucose after it exits the last prehydrolysis reactor.

  9. Progress in Induction Linacs

    SciTech Connect

    Caporaso, G J

    2000-09-27

    This presentation will be a broad survey of progress in induction technology over the past four years. Much work has been done on accelerators for hydrodynamic test radiography and other applications. Solid-state pulsers have been developed which can provide unprecedented flexibility and precision in pulse format and accelerating voltage for both ion and electron induction machines. Induction linacs can now be built which can operate with MHz repetition rates. Solid-state technology has also made possible the development of fast kickers for precision control of high current beams. New insulator technology has been developed which will improve conventional induction linacs in addition to enabling a new class of high gradient induction linacs.

  10. Sphingosylphosphorylcholine in cancer progress

    PubMed Central

    Yue, Hong-Wei; Jing, Qing-Chuan; Liu, Ping-Ping; Liu, Jing; Li, Wen-Jing; Zhao, Jing

    2015-01-01

    Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive sphingolipid in blood plasma, metabolizing from the hydrolysis of the membrane sphingolipid. It has been shown to exert multifunctional role in cell physiological regulation either as an intracellular second messenger or as an extracellular agent through G protein coupled receptors (GPCRs). Because of elevated levels of SPC in malicious ascites of patients with cancer, the role of SPC in tumor progression has prompted wide interest. The factor was reported to affect the proliferation and/or migration of many cancer cells, including pancreatic cancer cells, epithelial ovarian carcinoma cells, rat C6 glioma cells, neuroblastoma cells, melanoma cells, and human leukemia cells. This review covers current knowledge of the role of SPC in tumor. PMID:26550104

  11. Progressive familial intrahepatic cholestasis.

    PubMed

    Srivastava, Anshu

    2014-03-01

    Progressive familial intrahepatic cholestasis (PFIC) is a group of rare disorders which are caused by defect in bile secretion and present with intrahepatic cholestasis, usually in infancy and childhood. These are autosomal recessive in inheritance. The estimated incidence is about 1 per 50,000 to 1 per 100,000 births, although exact prevalence is not known. These diseases affect both the genders equally and have been reported from all geographical areas. Based on clinical presentation, laboratory findings, liver histology and genetic defect, these are broadly divided into three types-PFIC type 1, PFIC type 2 and PFIC type 3. The defect is in ATP8B1 gene encoding the FIC1 protein, ABCB 11 gene encoding BSEP protein and ABCB4 gene encoding MDR3 protein in PFIC1, 2 and 3 respectively. The basic defect is impaired bile salt secretion in PFIC1/2 whereas in PFIC3, it is reduced biliary phospholipid secretion. The main clinical presentation is in the form of cholestatic jaundice and pruritus. Serum gamma glutamyl transpeptidase (GGT) is normal in patients with PFIC1/2 while it is raised in patients with PFIC3. Treatment includes nutritional support (adequate calories, supplementation of fat soluble vitamins and medium chain triglycerides) and use of medications to relieve pruritus as initial therapy followed by biliary diversion procedures in selected patients. Ultimately liver transplantation is needed in most patients as they develop progressive liver fibrosis, cirrhosis and end stage liver disease. Due to the high risk of developing liver tumors in PFIC2 patients, monitoring is recommended from infancy. Mutation targeted pharmacotherapy, gene therapy and hepatocyte transplantation are being explored as future therapeutic options.

  12. Laboratory and field studies related to the hydrologic resources management program. Annual progress report, October 1, 1995--September 30, 1995

    SciTech Connect

    Thompson, J.L.

    1995-11-01

    In this report we describe the work done at Los Alamos National Laboratory in FY 1995 for the Hydrologic Resources Management Program funded by the US Department of Energy/Nevada Operations office. Budgetary cuts have required us to scale back our activities, particularly field work at the Nevada Test Site. We have collaborated with a number of government agencies and universities in work related to radionuclide migration through geologic media. In cooperation with Lawrence Livermore National Laboratory, we have demonstrated the utility of high-sensitivity gamma logging and have successfully improved the design of a bailer routinely used for water sampling. We analyzed a suite of side-wall samples from the BASEBALL drill-back and have interpreted the distribution pattern of test-related radionuclides. Though heterogeneously distributed, they show a general separation of volatile and refractory fractions. The distribution pattern suggests that there has been little movement of radioactive material within this cavity, which is 13 years old and below the static water level. This characterization of the BASEBALL cavity/chimney complex may have important implications for radionuclide migration elsewhere at the Nevada Test Site.

  13. Organic Nomenclature

    NASA Astrophysics Data System (ADS)

    Shaw, David B.; Yindra, Laura R.

    2003-10-01

    Organic Nomenclature requires the following software, which is available for free download from the Internet: Netscape Navigator, version 6.2 or higher, or Microsoft Internet Explorer, version 5.0 or higher.

  14. Organic photovoltaics

    NASA Astrophysics Data System (ADS)

    Leo, Karl

    2016-08-01

    Organic photovoltaics are on the verge of revolutionizing building-integrated photovoltaics. For other applications, however, several basic open scientific questions need answering to, in particular, further improve energy-conversion efficiency and lifetime.

  15. Organic Superconductors

    SciTech Connect

    Charles Mielke

    2009-02-27

    Intense magnetic fields are an essential tool for understanding layered superconductors. Fundamental electronic properties of organic superconductors are revealed in intense (60 tesla) magnetic fields. Properties such as the topology of the Fermi surface and the nature of the superconducting order parameter are revealed. With modest maximum critical temperatures~13K the charge transfer salt organic superconductors prove to be incredibly valuable materials as their electronically clean nature and layered (highly anisotropic) structures yield insights to the high temperature superconductors. Observation of de Haas-van Alphen and Shubnikov-de Haas quantum oscillatory phenomena, magnetic field induced superconductivity and re-entrant superconductivity are some of the physical phenomena observed in the charge transfer organic superconductors. In this talk, I will discuss the nature of organic superconductors and give an overview of the generation of intense magnetic fields; from the 60 tesla millisecond duration to the extreme 1000 tesla microsecond pulsed magnetic fields.

  16. Research Performance Progress Report

    SciTech Connect

    Theopold, Klaus H.

    2015-11-30

    The focus of this project was catalysis by ‘proton coupled electron transfer’ (PCET) to metal bound fragments derived from the most abundant small molecules (i. e. O2 and N2). There are many important chemical challenges that are tied to this fundamental reaction type. Among these are: metal catalyzed oxidations of organic molecules utilizing O2 as the oxidant; reduction of O2 to water close to the thermodynamic potential – in other words, the cathode of any fuel cell based on reactions with O 2; transfer of reduced nitrogen species to organic substrates; fixation of nitrogen at modest temperatures and pressures. Any one of these problems has obvious implications for the generation and/or utilization of energy on a large scale.

  17. Organ engineering--combining stem cells, biomaterials, and bioreactors to produce bioengineered organs for transplantation.

    PubMed

    Murphy, Sean Vincent; Atala, Anthony

    2013-03-01

    Often the only treatment available for patients suffering from diseased and injured organs is whole organ transplant. However, there is a severe shortage of donor organs for transplantation. The goal of organ engineering is to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Recent progress in stem cell biology, biomaterials, and processes such as organ decellularization and electrospinning has resulted in the generation of bioengineered blood vessels, heart valves, livers, kidneys, bladders, and airways. Future advances that may have a significant impact for the field include safe methods to reprogram a patient's own cells to directly differentiate into functional replacement cell types. The subsequent combination of these cells with natural, synthetic and/or decellularized organ materials to generate functional tissue substitutes is a real possibility. This essay reviews the current progress, developments, and challenges facing researchers in their goal to create replacement tissues and organs for patients.

  18. Liquid effluent/Hanford Environmental compliance FY 1995 Multi-Year Program Plan/Fiscal Year Work Plan, WBS 1.2.2.1 and 1.2.2.2

    SciTech Connect

    Not Available

    1994-09-01

    This document details the program effort to eliminate the use of the soil column for liquid effluent treatment and to manage current and future liquid effluent streams at the Hanford Site, in a safe responsible cost effective and legally compliant mannger. This should be achieved through planning, public and stakeholder interaction, definition of requiremtns for generators, and provision of timely treatment, stroage, disposal capability, and waste minimization of waste streams.

  19. Chronic progressive ophthalmoplegia with large-scale mtDNA rearrangement: can we predict progression?

    PubMed

    Auré, Karine; Ogier de Baulny, Hélène; Laforêt, Pascal; Jardel, Claude; Eymard, Bruno; Lombès, Anne

    2007-06-01

    The prognosis of chronic progressive ophthalmoplegia with large-scale mitochondrial DNA (mtDNA) may strikingly vary from mild slowly progressive myopathy to severe multi-organ involvement. Evaluation of the disease course at the beginning of the disease is reputed impossible. To address the existence of predictive prognostic clues of these diseases, we classified 69 patients with chronic progressive ophthalmoplegia and large size mtDNA deletion into two groups according to the presence of manifestations from brain, inner ear or retina. These manifestations were present in 29 patients (CPEO/+N group) and absent in 40 patients (CPEO/-N group). We retrospectively established the clinical history of the patients and characterized their genetic alteration (amount of residual normal mtDNA molecules, site, size and percentage of the mtDNA deletion in 116 DNA samples from muscle, blood, urinary and buccal cells). In both clinical groups, the disease was progressive and heart conduction defects were frequent. We show that the CPEO/+N phenotype segregated with severe prognosis in term of rate of progression, multi-organs involvement and rate of survival. Age at onset appeared a predictive factor. The risk to develop a CPEO/+N phenotype was high when onset was before 9 years of age and low when onset was after 20 years of age. The presence and proportion of the mtDNA deletion in blood was also significantly associated with the CPEO/+N phenotype. This study is the first to establish the natural history of chronic ophthalmoplegia with mtDNA deletion in a large series of patients and to look for parameters potentially predictive of the patients' clinical course.

  20. Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs

    PubMed Central

    Koenig, Alice; Thaunat, Olivier

    2016-01-01

    The progressive organization of immune effectors into functional ectopic lymphoid structures, named tertiary lymphoid organs (TLO), has been observed in many conditions in which target antigens fail to be eliminated by the immune system. Not surprisingly, TLO have been recurrently identified in chronically rejected allografts. Although significant progress has been made over the last decades in understanding the molecular mechanisms involved in TLO development (a process named lymphoid neogenesis), the role of intragraft TLO (if any) in chronic rejection remains elusive. The prevailing dogma is that TLO contribute to graft rejection by generating and propagating local humoral and cellular alloimmune responses. However, TLO have been recently observed in long-term accepting allografts, suggesting that they might also be able to regulate alloimmune responses. In this review, we discuss our current understanding of how TLO are induced and propose a unified model in which TLO can play deleterious or regulatory roles and therefore actively modulate the kinetics of chronic rejection. PMID:28082981

  1. Using Learning Progressions to Monitor Progress across Grades

    ERIC Educational Resources Information Center

    Hess, Karin K.

    2010-01-01

    Learning progressions (LPs)--descriptive continuums of how students develop and demonstrate more sophisticated understanding over time--have become an increasingly important tool in today's science classrooms. Here the author discusses some of the research behind learning progressions and presents The Science Inquiry Profile for PreK-4. This is a…

  2. Progressive systemic sclerosis associated with exposure to trichloroethylene.

    PubMed

    Lockey, J E; Kelly, C R; Cannon, G W; Colby, T V; Aldrich, V; Livingston, G K

    1987-06-01

    Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Although neither the etiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of seemingly unrelated compounds, including exposure to organic solvents. The authors describe a 47-year-old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux esophagitis, microangiopathic hemolytic anemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.

  3. Biomineralization-inspired synthesis of functional organic/inorganic hybrid materials: organic molecular control of self-organization of hybrids.

    PubMed

    Arakaki, Atsushi; Shimizu, Katsuhiko; Oda, Mayumi; Sakamoto, Takeshi; Nishimura, Tatsuya; Kato, Takashi

    2015-01-28

    Organisms produce various organic/inorganic hybrid materials, which are called biominerals. They form through the self-organization of organic molecules and inorganic elements under ambient conditions. Biominerals often have highly organized and hierarchical structures from nanometer to macroscopic length scales, resulting in their remarkable physical and chemical properties that cannot be obtained by simple accumulation of their organic and inorganic constituents. These observations motivate us to create novel functional materials exhibiting properties superior to conventional materials--both synthetic and natural. Herein, we introduce recent progress in understanding biomineralization processes at the molecular level and the development of organic/inorganic hybrid materials by these processes. We specifically outline fundamental molecular studies on silica, iron oxide, and calcium carbonate biomineralization and describe material synthesis based on these mechanisms. These approaches allow us to design a variety of advanced hybrid materials with desired morphologies, sizes, compositions, and structures through environmentally friendly synthetic routes using functions of organic molecules.

  4. Progressive familial intrahepatic cholestasis.

    PubMed

    Jacquemin, Emmanuel

    2012-09-01

    Progressive familial intrahepatic cholestasis (PFIC) refers to a heterogeneous group of autosomal-recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin. The exact prevalence remains unknown, but the estimated incidence varies between 1/50,000 and 1/100,000 births. Three types of PFIC have been identified and associated with mutations in hepatocellular transport-system genes involved in bile formation. PFIC1 and PFIC2 usually appear in the first months of life, whereas onset of PFIC3 may arise later in infancy, in childhood or even during young adulthood. The main clinical manifestations include cholestasis, pruritus and jaundice. PFIC patients usually develop fibrosis and end-stage liver disease before adulthood. Serum gamma-glutamyltransferase (GGT) activity is normal in PFIC1 and PFIC2 patients, but is elevated in PFIC3 patients. Both PFIC1 and PFIC2 are caused by impaired bile salt secretion due to defects in ATP8B1 encoding the FIC1 protein and in ABCB11 encoding bile salt export pump (BSEP) protein, respectively. Defects in ABCB4, encoding multidrug resistance 3 protein (MDR3), impair biliary phospholipid secretion, resulting in PFIC3. Diagnosis is based on clinical manifestations, liver ultrasonography, cholangiography and liver histology, as well as on specific tests to exclude other causes of childhood cholestasis. MDR3 and BSEP liver immunostaining, and analysis of biliary lipid composition should help to select PFIC candidates for whom genotyping could be proposed to confirm the diagnosis. Antenatal diagnosis may be proposed for affected families in which a mutation has been identified. Ursodeoxycholic acid (UDCA) therapy should be initiated in all patients to prevent liver damage. In some PFIC1 and PFIC2 patients, biliary diversion may also relieve pruritus and slow disease progression. However, most PFIC patients are ultimately candidates for liver transplantation. Monitoring of liver tumors

  5. Progressive familial intrahepatic cholestasis.

    PubMed

    Davit-Spraul, Anne; Gonzales, Emmanuel; Baussan, Christiane; Jacquemin, Emmanuel

    2009-01-08

    Progressive familial intrahepatic cholestasis (PFIC) refers to heterogeneous group of autosomal recessive disorders of childhood that disrupt bile formation and present with cholestasis of hepatocellular origin. The exact prevalence remains unknown, but the estimated incidence varies between 1/50,000 and 1/100,000 births. Three types of PFIC have been identified and related to mutations in hepatocellular transport system genes involved in bile formation. PFIC1 and PFIC2 usually appear in the first months of life, whereas onset of PFIC3 may also occur later in infancy, in childhood or even during young adulthood. Main clinical manifestations include cholestasis, pruritus and jaundice. PFIC patients usually develop fibrosis and end-stage liver disease before adulthood. Serum gamma-glutamyltransferase (GGT) activity is normal in PFIC1 and PFIC2 patients, but is elevated in PFIC3 patients. Both PFIC1 and PFIC2 are caused by impaired bile salt secretion due respectively to defects in ATP8B1 encoding the FIC1 protein, and in ABCB11 encoding the bile salt export pump protein (BSEP). Defects in ABCB4, encoding the multi-drug resistant 3 protein (MDR3), impair biliary phospholipid secretion resulting in PFIC3. Diagnosis is based on clinical manifestations, liver ultrasonography, cholangiography and liver histology, as well as on specific tests for excluding other causes of childhood cholestasis. MDR3 and BSEP liver immunostaining, and analysis of biliary lipid composition should help to select PFIC candidates in whom genotyping could be proposed to confirm the diagnosis. Antenatal diagnosis can be proposed for affected families in which a mutation has been identified. Ursodeoxycholic acid (UDCA) therapy should be initiated in all patients to prevent liver damage. In some PFIC1 or PFIC2 patients, biliary diversion can also relieve pruritus and slow disease progression. However, most PFIC patients are ultimately candidates for liver transplantation. Monitoring of

  6. Progress and challenges in controlling neglected zoonotic diseases.

    PubMed

    Jarvis, Suzanne

    2015-01-24

    Suzanne Jarvis reports from the Fourth International Meeting on the Control of Neglected Zoonotic Diseases, hosted by the World Health Organization in Geneva in November. The meeting looked at progress that has been made in controlling these diseases and at what the next steps should be for further control.

  7. Beneficial uses program. Progress report, period ending March 31, 1980

    SciTech Connect

    Not Available

    1980-08-01

    Progress is reported on dried sewage sludge irradiation, on irradiated sludge use as cattle feed, the inactivation of enteric organisms, the use of irradiation for citrus fruit disinfestation, and the effects of sludge addition on herbicide behavior in soils under laboratory conditions. (LCL)

  8. Progress Report on Rural Development for Fiscal Year 1970.

    ERIC Educational Resources Information Center

    Department of Agriculture, Washington, DC.

    Rural development progress relative to State-U.S. Department of Agriculture (USDA) committees is presented via exemplary citation in this 1970 report. Summaries are given for: (1) Status of State-USDA Organization for Rural Development, (2) Functional Relationships of USDA Committees on Rural Development, (3) Activities and Projects Underway, (4)…

  9. National Vocational Qualifications and Further Education. A Commentary on Progress.

    ERIC Educational Resources Information Center

    Pursaill, John

    This report describes the complexities of the process of developing National Vocational Qualifications (NVQ) in Britain. It identifies many of the organizations and agencies that are involved in the establishment of a new framework of vocational qualifications. Issues, such as progression and credit accumulation, assessment of open access and…

  10. Bacterial chromosome organization and segregation

    PubMed Central

    Badrinarayanan, Anjana; Le, Tung BK; Laub, Michael T

    2016-01-01

    If fully stretched out, a typical bacterial chromosome would be nearly one millimeter long, or approximately 1000 times the length of a cell. Not only must cells massively compact their genetic material, but they must also organize their DNA in a manner that is compatible with a range of cellular processes, including DNA replication, DNA repair, homologous recombination, and horizontal gene transfer. Recent work, driven in part by technological advances, has begun to reveal the general principles of chromosome organization in bacteria. Here, drawing on studies of many different organisms, we review the emerging picture of how bacterial chromosomes are structured at multiple length-scales, highlighting the functions of various DNA-binding proteins and impact of physical forces. Additionally, we discuss the spatial dynamics of chromosomes, particularly during their segregation to daughter cells. Although there has been tremendous progress, we also highlight gaps that remain in understanding chromosome organization and segregation. PMID:26566111

  11. Bacterial Chromosome Organization and Segregation

    PubMed Central

    Toro, Esteban; Shapiro, Lucy

    2010-01-01

    Bacterial chromosomes are generally ∼1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. Recent advances in cell-imaging technology with subdiffraction resolution have revealed that the bacterial nucleoid is reliably oriented and highly organized within the cell. Such organization is transmitted from one generation to the next by progressive segregation of daughter chromosomes and anchoring of DNA to the cell envelope. Active segregation by a mitotic machinery appears to be common; however, the mode of chromosome segregation varies significantly from species to species. PMID:20182613

  12. Annual Technical Progress Report

    SciTech Connect

    Ayman I. Hawari

    2002-10-02

    This report describes the results generated during phase 1 of this project. During this phase, the main tools that are used to compute the thermal neutron scattering kernels for graphite, beryllium, beryllium oxide, zirconium hydride, light water, polyethylene were implemented and tested. This includes a modified NJOY/LEAPR code system, the GASKET code, and the ab initio condensed matter codes VASP and PHONON. Thermal neutron scattering kernels were generated for graphite, beryllium, beryllium oxide. In the case of graphite, new phonon spectra were examined. The first is a spectrum based on experiments performed at Oak Ridge National Laboratory in the early seventies, and the second is generated using the ab initio methods. In the case of beryllium, and beryllium oxide, a synthetic approach for generating the phonon spectra was implemented. In addition, significant progress was made on an experiment to benchmark the graphite scattering kernels was made. The simulations of this experiment show that differences on the order of a few percent, in Pu-239 detector responses, can be expected due to the use of different scattering kernels. (B204) NOT A FINAL REPORT

  13. Technical progress report

    SciTech Connect

    1996-10-01

    This report summarizes experimental and theoretical work in basic nuclear physics carried out between October 1, 1995, the closing of our last Progress Report, and September 30, 1996 at the Nuclear Physics Laboratory of the University of Colorado, Boulder, under contracts DE-FG03-93ER-40774 and DE-FG03-95ER-40913 with the United States Department of Energy. The experimental contract supports broadly-based experimental research in intermediate energy nuclear physics. This report includes results from studies of Elementary Systems involving the study of the structure of the nucleon via polarized high-energy positron scattering (the HERMES experiment) and lower energy pion scattering from both polarized and unpolarized nucleon targets. Results from pion- and kaon-induced reactions in a variety of nuclear systems are reported under the section heading Meson Reactions; the impact of these and other results on understanding the nucleus is presented in the Nuclear Structure section. In addition, new results from scattering of high-energy electrons (from CEBAF/TJNAF) and pions (from KEK) from a broad range of nuclei are reported in the section on Incoherent Reactions. Finally, the development and performance of detectors produced by the laboratory are described in the section titled Instrumentation.

  14. 1993 PVUSA progress report

    SciTech Connect

    1993-12-31

    Photovoltaics for Utility Scale Applications (PVUSA) is a national public-private partnership that is assessing and demonstrating the viability of utility-scale photovoltaic (PV) electric generation systems and recent developments in module technology. This report updates the progress of the PVUSA project, review the status and performance of all PV installations during 1993, and summarizes key accomplishments and conclusions for the year. The PVUSA project has five objectives designed to narrow the gap between a large utility industry that is unfamiliar with PV, and a small PV industry that is aware of a potentially large utility market but unfamiliar with how to meet its requirements. The objectives are: to evaluate the performance, reliability, and cost of promising PV modules and balance-of-system (BOS) components side-by-side at a single location; to assess PV system operation and maintenance (O and M) in a utility setting; to compare PV technologies in diverse geographic areas; to provide US utilities with hands-on experience in designing, procuring, and operating PV systems; and to document and disseminate knowledge gained from the project.

  15. Progressive myoclonic epilepsies

    PubMed Central

    Michelucci, Roberto; Canafoglia, Laura; Striano, Pasquale; Gambardella, Antonio; Magaudda, Adriana; Tinuper, Paolo; La Neve, Angela; Ferlazzo, Edoardo; Gobbi, Giuseppe; Giallonardo, Anna Teresa; Capovilla, Giuseppe; Visani, Elisa; Panzica, Ferruccio; Avanzini, Giuliano; Tassinari, Carlo Alberto; Bianchi, Amedeo; Zara, Federico

    2014-01-01

    Objective: To define the clinical spectrum and etiology of progressive myoclonic epilepsies (PMEs) in Italy using a database developed by the Genetics Commission of the Italian League against Epilepsy. Methods: We collected clinical and laboratory data from patients referred to 25 Italian epilepsy centers regardless of whether a positive causative factor was identified. PMEs of undetermined origins were grouped using 2-step cluster analysis. Results: We collected clinical data from 204 patients, including 77 with a diagnosis of Unverricht-Lundborg disease and 37 with a diagnosis of Lafora body disease; 31 patients had PMEs due to rarer genetic causes, mainly neuronal ceroid lipofuscinoses. Two more patients had celiac disease. Despite extensive investigation, we found no definitive etiology for 57 patients. Cluster analysis indicated that these patients could be grouped into 2 clusters defined by age at disease onset, age at myoclonus onset, previous psychomotor delay, seizure characteristics, photosensitivity, associated signs other than those included in the cardinal definition of PME, and pathologic MRI findings. Conclusions: Information concerning the distribution of different genetic causes of PMEs may provide a framework for an updated diagnostic workup. Phenotypes of the patients with PME of undetermined cause varied widely. The presence of separate clusters suggests that novel forms of PME are yet to be clinically and genetically characterized. PMID:24384641

  16. Progressive familial intrahepatic cholestasis.

    PubMed

    Jacquemin, E

    1999-06-01

    Progressive familial intrahepatic cholestasis (PFIC), also known as Byler disease, is an inherited disorder of childhood in which cholestasis of hepatocellular origin often presents in the neonatal period and leads to death from liver failure before adolescence. The pattern of appearance of affected children within families is consistent with autosomal recessive inheritance. Several studies have provided support for the heterogeneity of this clinical entity suggesting the existence of different types due to different disorders affecting the hepatocyte and related to defects of bile acid secretion or bile acid metabolism. Recent molecular and genetic studies have identified genes responsible for three types of PFIC and have shown that PFIC was related to mutations in hepatocellular transport system genes involved in bile formation. These findings now provide specific diagnostic tools for the investigation of children with PFIC and should allow prenatal diagnosis in the future. Genotype-phenotype correlations performed in patients treated with ursodeoxycholic acid or biliary diversion should allow those PFIC patients who could benefit from these therapies to be precisely identified. In the future, other therapies, such as cell and gene therapies, might be considered and could also represent an alternative to liver transplantation.

  17. Progressive familial intrahepatic cholestasis.

    PubMed

    Cavestro, Giulia Martina; Frulloni, Luca; Cerati, Elena; Ribeiro, Luciana Andrea; Corrente, Vincenzo; Sianesi, Mario; Franzè, Angelo; Di Mario, Francesco

    2002-01-01

    Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal recessive childhood cholestasis of hepatocellular origin. PFIC 1, also known as Byler disease, was first described in Amish kindred. It is characterized by cholestasis often arising in the neonatal period and it leads to death due to liver failure. PFIC 1, like Benign Recurrent Intrahepatic Cholestasis (BRIC) which is the benign form of the same disease, recognizes mutations in the ATP8B1 gene. PFIC 2 disease is clinically similar to PFIC 1 but it has a different gene mutation causing a defect in the Bile Salt Export Pump (BSEP), exclusively expressed in the liver and involved in the canalicular secretion of bile acids. PFIC 3 usually appears later in life and it has a higher risk of portal hypertension, gastrointestinal bleeding and liver failure. This particular form of disease (the only one with high serum values of g-glutamil transpeptidase), is associated to a genetic defect in the class III multidrug resistance protein (MDR). External biliary diversion and ursodeoxycholic acid therapy, should be considered as the initial therapy in these patients, even if liver transplantation still seems to be the only solution for most patients.

  18. W7-X Progress

    SciTech Connect

    Gasparotto, M.; Erckmann, V.; Gardebrecht, W.; Rummel, Th.; Schauer, F.; Wanner, M.; Wegener, L.

    2005-04-15

    The WENDELSTEIN 7-X stellarator (W7-X) is the next step device in the stellarator line of IPP and is presently under construction at the Greifswald branch institute. The experiment aims at demonstrating the steady state capability of a stellarator machine at reactor relevant parameters. An important feature of W7-X is the high geometrical accuracy of the magnetic configuration which implies tight tolerances in the construction and assembly phases. The magnetic system consists of 50 non planar and 20 planar superconducting coils. Critical components are the coil support elements connecting the coil to the central mechanical structure and the inter-coil elements connecting the coils one to the other. Efficient thermal insulation of the superconducting coils is achieved by high vacuum and multi-layer insulation. The plasma vessel is composed of 10 half-modules welded together during the assembly phase. A 10 MW ECRH system with CW-capability operation at 140 GHz is required to meet the scientific objective of W7-X.The paper will report the recent progress on W7-X with particular emphasis on the components where high technology solutions have been applied.

  19. Quarterly Progress Report

    SciTech Connect

    David Gray; Glen Tomlinson

    1998-11-12

    The Federal Energy Technology Center (FETC) at Pittsburgh contracted with the MJTRE Corporation to perform Research Guidance Studies that will assist the Center and other relevant offices in the Department of Energy in evaluating and prioritizing research in the areas of coal and natural gas conversion. MITRE was reorganized in December 1995, which resulted in the formation of Mitretek Systems Inc. Mitretek has been performing this work on MITRE's behalf awaiting completion of contract novation to Mitretek. The contract was novated in February 1998 to Mitretek Systems. The overall objectives of this contract are to provide support to DOE in the following areas: (1) technical and economic analyses of current and future coal-based energy conversion technologies and other similar emerging technologies such as coal-waste coprocessing, natural gas conversion, and biomass conversion technologies for the production of fuels, chemicals and electric power,(2) monitor progress in these technologies with respect to technical, economic, and environmental impact (including climate change), (3) conduct specific and generic project economic and technical feasibility studies based on these technologies, (4) identify long-range R&D areas that have the greatest potential for process improvements, and (5) investigate optimum configurations and associated costs for production of high quality energy products via refining and their performance in end-use applications.

  20. Nuclear chemistry progress report

    SciTech Connect

    Viola, V.E.; Kwiatkowski, K.

    1993-08-01

    This is the annual progress report for the Indiana University nuclear chemistry program for the 1992/1993 year. Accomplishments include the construction, testing, and initial experimental runs of the Indiana Silicon Sphere (ISiS) 4{pi} charged particle detector. ISiS is designed to study energy dissipation and multifragmentation phenomena in light-ion-induced nuclear reactions at medium-to-high energies. Its second test run was to examine 3.6 GeV {sup 3}He beam reactions at Laboratoire National Saturne (LNS) in Saclay. The development and deployment of this system has occupied a great deal of the groups effort this reporting period. Additional work includes: calculations of isotopic IMF yields in the {sup 4}He + {sup 116,124}Sn reaction; cross sections for A = 6 - 30 fragments from the {sup 4}He + {sup 28}Si reaction at 117 and 198 MeV; charging effects of passivated silicon detectors; neck emission of intermediate-mass fragments in the fission of hot heavy nuclei.

  1. AGS experiments - 1994, 1995, 1996

    SciTech Connect

    Depken, J.C.

    1997-01-01

    This report contains the following information on the Brookhaven AGS Accelerator complex: FY 1996 AGS schedule as run; FY 1997 AGS schedule (working copy); AGS beams 1997; AGS experimental area FY 1994 physics program; AGS experimental area FY 1995 physics program; AGS experimental area FY 1996 physics program; AGS experimental area FY 1997 physics program (in progress); a listing of experiments by number; two-phage summaries of each experiment begin here, also ordered by number; listing of publications of AGS experiments begins here; and listing of AGS experimenters begins here.

  2. Organ transplantation in Tunisia.

    PubMed

    El Matri, Aziz; Ben Abdallah, Taieb

    2015-04-01

    Kidney transplants were first performed in Tunisia in 1986, and transplants soon extended to other organs including the heart, liver, and pancreas. Live-related donor and deceased-donor kidney transplants were both began in the summer of 1986. An organ procurement and transplant law was passed in March 1991, and the National Centre for Advancement of Organ Transplantation was created in 1995. The number of transplantation units has increased to 7 throughout the country, and the yearly transplant number has progressively increased to 139 in 2010, including 20% from deceased kidney donors. Despite these gains, the need continues to grow. Heart transplants began in January 1993, and Tunisia and Jordan are currently the only Arab countries where it is practiced. However, only 16 patients have received a heart transplant as of 2004, and the number of recipients has decreased in the past 10 years. Liver transplants are rare in other Arab countries, but began in Tunisia in January 1998. Over 10 years, 38 patients benefited from this procedure. After a few years of stagnation, the number of liver transplants is increasing. While all types of transplantation are needed, kidney transplantation is a priority in Tunisia. The target is to perform 400 transplants annually, which would require a long-term strategy to provide full financial coverage using the National Health Insurance Funds in both the public and private sectors.

  3. [Multiple organ dysfunction syndrome].

    PubMed

    Cuenca Solanas, M

    1999-01-01

    Multiple organ dysfunction syndrome (MODS) is a clinical situation that has been described as a result of the rapid progress and advances that have been made in recent decades in the physiology, diagnosis, and therapeutic support of critically ill patients. In 1991, in view of the confusing terminology used to characterize processes coursing with systemic inflammatory response syndrome (SIRS), a consensus conference was held. A series of basic definitions were established and the term "multiple organ failure" was replace by MODS. In response to outside aggression, the organism tries to defend itself with two mechanisms: a non-specific humoral and cellular response called inflammation, and a specific antigenic response that modifies the genetic codes of cells of the defense system and constitutes an immunological response. At present it is thought that the inflammatory response is activated (SIRS) in response to an uncontrolled aggression, but an antiinflammatory response syndrome (ARS) exists as well. An exaggerated SIRS can lead to MODS. MODS usually debuts with pulmonary dysfunction. If the aggression persists, cardiovascular, renal, hepatic, coagulation, central nervous system, gastrointestinal metabolism, neuroendocrine and musculoskeletal failure follow. A series of causes often trigger this syndrome and certain factors favor it. Prevention of these causes and factors in fundamental for controlling the occurrence of MODS. At present, there is no clear treatment for MODS, although numerous studies designed to block the release of certain proinflammatory mediators or to neutralize antiinflammatory responses are being carried out.

  4. The Progress of Nations, 1999.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    This report summarizes the latest available statistics on international progress on children's well-being. Each of the report's sections contains a commentary, related statistics, and a discussion on progress and disparity in the section's particular area. Following a foreword by United Nations Secretary-General Kofi A. Annan, the sections of the…

  5. Progress in NASA Rotorcraft Propulsion

    NASA Technical Reports Server (NTRS)

    DellaCorte, Christopher; Johnson, Susan M.

    2008-01-01

    This presentation reviews recent progress made under NASA s Subsonic Rotary Wing (SRW) propulsion research activities. Advances in engines, drive systems and optimized propulsion systems are discussed. Progress in wide operability compressors, modeling of variable geometry turbine performance, foil gas bearings and multi-speed transmissions are presented.

  6. The Progress of Nations, 2000.

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    This report summarizes the latest available statistics on international progress on children's well-being. Each section of the report contains a commentary, related statistics, and a discussion on progress and disparity in the section's particular area. Following a foreword by United Nations Secretary-General Kofi A. Annan, the sections of the…

  7. Scientific progress: Knowledge versus understanding.

    PubMed

    Dellsén, Finnur

    2016-04-01

    What is scientific progress? On Alexander Bird's epistemic account of scientific progress, an episode in science is progressive precisely when there is more scientific knowledge at the end of the episode than at the beginning. Using Bird's epistemic account as a foil, this paper develops an alternative understanding-based account on which an episode in science is progressive precisely when scientists grasp how to correctly explain or predict more aspects of the world at the end of the episode than at the beginning. This account is shown to be superior to the epistemic account by examining cases in which knowledge and understanding come apart. In these cases, it is argued that scientific progress matches increases in scientific understanding rather than accumulations of knowledge. In addition, considerations having to do with minimalist idealizations, pragmatic virtues, and epistemic value all favor this understanding-based account over its epistemic counterpart.

  8. Organizing chordates with an organizer.

    PubMed

    Garcia-Fernàndez, Jordi; D'Aniello, Salvatore; Escrivà, Hector

    2007-07-01

    Understanding how the chordate body plan originated and evolved is still controversial. The discovery by Spemann and Mangold in 1924 of the vertebrate organizer and its inductive properties in patterning the AP and DV axis was followed by a long gap until the 1960s when scientists started characterizing the molecular events responsible for such inductions. However, the evolutionary origin of the organizer itself remained obscure until very recently; did it appear together with the origin and radiation of vertebrates, or was it a chordate affair? A recent study by Yu and collaborators,1 which analyses the expression of several organizer-specific genes in amphioxus together with recent phylogenetic data that reversed the position of invertebrate extant chordates (e.g. urochordates and cephalochordates), indicates that the organizer probably appeared in early chordates. It likely had separate signalling centres generating BMP and Wnt signalling gradients along the DV and AP axis. The organizer was then lost in the urochordate lineage, most probably as an adaptation to a rapid and determinate development.

  9. The Thermochronologist's Progress

    NASA Astrophysics Data System (ADS)

    Zeitler, P. K.

    2011-12-01

    We owe our current understanding of thermochronology less to a series of revolutionary insights than to a somewhat uneven intellectual pilgrimage that over fifty years has progressed in fits and starts. Though hampered at times by overenthusiasm, oversimplification, and misunderstandings, on balance the field advanced thanks to a blend of curiosity-driven research, tool-building motivated by new ideas about Earth science, and improvements in technology. But now that we've exploited most radiogenic systems and the major minerals that host them, and now that our models can devour CPU time along with the best of them, are we done? Have we reached peak thermochron? The answer of course is no, and papers in this session will demonstrate what new technologies and techniques might have to offer in the coming years. However, I will argue that the discipline as a whole has matured to a point where if thermochronology is to remain a mainstream tool as opposed to a weekend sport, we need to get serious about several challenges. The most fundamental challenge is that current geodynamic models (and even more complex models we can envision coding) have outpaced our meagre stockpile of kinetic calibrations, our understanding of detailed isotope systematics, and our ability to generate data with sufficient throughput. These issues will not be addressed adequately through the business-as-usual approach that brought us to our current knowledge, and some community effort will probably be needed to coordinate the hard work that will be required. But any serious attempt to answer important questions with accurate thermal histories that have low and well-defined uncertainties will require that we actually know the kinetics for the specific samples we are analyzing, that we fully understand scatter in the data, that we work with the large sample numbers that are required for some problems like landscape evolution, and that inversion tools fully explore the important aspects of both the

  10. Textual Organization.

    ERIC Educational Resources Information Center

    Hays, David G.

    Aside from phonological and syntactical structures, text is organized by its dramatis personae, plot, figures, point of view, and theme. These are, respectively, the entities mentioned, the spatial-temporal and causal linkages of events, comparisons and contrasts, propositional attitudes, and correspondence to some pattern. These modes of…

  11. Classroom Organization

    ERIC Educational Resources Information Center

    Technology & Learning, 2005

    2005-01-01

    Good organization skills are key to running an efficient classroom, and having the right tools makes it easier to manage all of the tasks, save time, and be more productive. Having the power of information when and where anyone need it makes a difference in how well any teacher runs the classroom and knows his or her students. A Palm handheld…

  12. Final Progress Report

    SciTech Connect

    Josef Michl

    2011-10-31

    In this project we have established guidelines for the design on organic chromophores suitable for producing high triplet yields via singlet fission. We have proven their utility by identifying a chromophore of a structural class that had never been examined for singlet fission before, 1,3-diphenylisobenzofuran, and demonstrating in two independent ways that a thin layer of this material produces a triplet yield of 200% within experimental error. We have also designed a second chromophore of a very different type, again of a structural class that had not been examined for singlet fission before, and found that in a thin layer it produces a 70% triplet yield. Finally, we have enhanced the theoretical understanding of the quantum mechanical nature of the singlet fission process.

  13. Vectorial electron transfer in spatially ordered arrays. Progress report, January 1992--January 1993

    SciTech Connect

    Fox, M.A.

    1993-02-01

    Progress was made on synthesis of new materials for directional electron transfer (block copolymers and helical oligopeptides), preparation and characterization of anisotropic composites bearing organics and inorganics, electrocatalysis (redox-activated catalysts), and surface modifications of metals and semiconductors.

  14. Progress in hydrogeochemistry

    SciTech Connect

    Matthess G.

    1992-01-01

    The book contains fifty-seven research papers representing the results of a six-year program, Hydrogeochemical Processes in the Hydrologic Cycle Within the Unsaturated and Saturated Zones, supported by the DFG (the German equivalent of NSF), plus introductory sections and a final chapter by the editors. The work was conducted at fourteen field sites around Germany plus one, a gypsum karst, in Tunisia, and one in Turkey. The papers cover a wide range of topics, as summarized by the subtitle, Organics-Carbonate Systems-Silicate Systems-Microbiology-Models. The Organics Section focuses on isolation and characterization of humic substances and on the interaction of inorganics with humic substances. It is mostly methodology, notably the use of pyrolysis-mass spectrometry, with one paper on field results at the end. The section on Carbonate Systems includes a review of carbonate dissolution kinetics, a review of methodologies for sampling soil solutions, a set of field studies that integrate very well dissolution kinetics and stable-isotope mass balance arguments, and finally three papers on gypsum karst, dedolomitization, and paleokarst sediments in semi-arid regions. Silicate Systems includes several excellent papers on the redox reactions in soils and groundwater, using isotopes of nitrogen and sulfur to constrain the reactions. There are also papers on aluminum speciation and silicate dissolution kinetics. The Microbiology section includes valuable overviews of groundwater microbiology and sampling methods, together with four field studies at different sites. The Modeling section at the end is concerned primarily with chemical and mass balance modeling. The overall focus of the book is on the functioning of the natural system; there is not much mention of anthropogenic pollutants other than acid deposition and fertilizers.

  15. Inverted organic photovoltaic cells.

    PubMed

    Wang, Kai; Liu, Chang; Meng, Tianyu; Yi, Chao; Gong, Xiong

    2016-05-21

    The advance in lifestyle, modern industrialization and future technological revolution are always at high expense of energy consumption. Unfortunately, there exist serious issues such as limited storage, high cost and toxic contamination in conventional fossil fuel energy sources. Instead, solar energy represents a renewable, economic and green alternative in the future energy market. Among the photovoltaic technologies, organic photovoltaics (OPVs) demonstrate a cheap, flexible, clean and easy-processing way to convert solar energy into electricity. However, OPVs with a conventional device structure are still far away from industrialization mainly because of their short lifetime and the energy-intensive deposition of top metal electrode. To address the stability and cost issue simultaneously, an inverted device structure has been introduced into OPVs, bridging laboratory research with practical application. In this review, recent progress in device structures, working mechanisms, functions and advances of each component layer as well their correlations with the efficiency and stability of inverted OPVs are reviewed and illustrated.

  16. Transitioning organic synthesis from organic solvents to water. What's your E Factor?

    PubMed Central

    Lipshutz, Bruce H.; Ghorai, Subir

    2014-01-01

    Traditional organic chemistry, and organic synthesis in particular, relies heavily on organic solvents, as most reactions involve organic substrates and catalysts that tend to be water-insoluble. Unfortunately, organic solvents make up most of the organic waste created by the chemical enterprise, whether from academic, industrial, or governmental labs. One alternative to organic solvents follows the lead of Nature: water. To circumvent the solubility issues, newly engineered “designer” surfactants offer an opportunity to efficiently enable many of the commonly used transition metal-catalyzed and related reactions in organic synthesis to be run in water, and usually at ambient temperatures. This review focuses on recent progress in this area, where such amphiphiles spontaneously self-aggregate in water. The resulting micellar arrays serve as nanoreactors, obviating organic solvents as the reaction medium, while maximizing environmental benefits. PMID:25170307

  17. Transitioning organic synthesis from organic solvents to water. What's your E Factor?

    PubMed

    Lipshutz, Bruce H; Ghorai, Subir

    2014-08-01

    Traditional organic chemistry, and organic synthesis in particular, relies heavily on organic solvents, as most reactions involve organic substrates and catalysts that tend to be water-insoluble. Unfortunately, organic solvents make up most of the organic waste created by the chemical enterprise, whether from academic, industrial, or governmental labs. One alternative to organic solvents follows the lead of Nature: water. To circumvent the solubility issues, newly engineered "designer" surfactants offer an opportunity to efficiently enable many of the commonly used transition metal-catalyzed and related reactions in organic synthesis to be run in water, and usually at ambient temperatures. This review focuses on recent progress in this area, where such amphiphiles spontaneously self-aggregate in water. The resulting micellar arrays serve as nanoreactors, obviating organic solvents as the reaction medium, while maximizing environmental benefits.

  18. Nanostructured organic and hybrid solar cells.

    PubMed

    Weickert, Jonas; Dunbar, Ricky B; Hesse, Holger C; Wiedemann, Wolfgang; Schmidt-Mende, Lukas

    2011-04-26

    This Progress Report highlights recent developments in nanostructured organic and hybrid solar cells. The authors discuss novel approaches to control the film morphology in fully organic solar cells and the design of nanostructured hybrid solar cells. The motivation and recent results concerning fabrication and effects on device physics are emphasized. The aim of this review is not to give a summary of all recent results in organic and hybrid solar cells, but rather to focus on the fabrication, device physics, and light trapping properties of nanostructured organic and hybrid devices.

  19. Vertebrate Endoderm Development and Organ Formation

    PubMed Central

    Zorn, Aaron M.; Wells, James M.

    2010-01-01

    The endoderm germ layer contributes to the respiratory and gastrointestinal tracts, and all of their associated organs. Over the past decade, studies in vertebrate model organisms; including frog, fish, chick, and mouse; have greatly enhanced our understanding of the molecular basis of endoderm organ development. We review this progress with a focus on early stages of endoderm organogenesis including endoderm formation, gut tube morphogenesis and patterning, and organ specification. Lastly, we discuss how developmental mechanisms that regulate endoderm organogenesis are used to direct differentiation of embryonic stem cells into specific adult cell types, which function to alleviate disease symptoms in animal models. PMID:19575677

  20. Surviving at a distance: organ specific metastasis

    PubMed Central

    Obenauf, Anna C.; Massagué, Joan

    2015-01-01

    The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer related mortality. Once established, metastasis is devastating, yet only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ specific and consequently demand distinct mechanisms for metastatic colonization. Here we review the metastatic traits that allow cancer cells to colonize distinct organ sites. PMID:26693180

  1. Recent advances in organ microcirculation research.

    PubMed

    Tsuchiya, M; Oda, M

    1987-01-01

    This review article dealt with progress in the research of gastroenterological organ microcirculation in Japan. It must be emphasized that this remarkable progress particularly in intravital microcirculatory observations at organ level is attributable to great improvement of microscopic devices combined with computerized system, development of new techniques for measuring microcirculatory blood flow and pioneering of a variety of fluorescent and isotope-labelled tracers. Little attention has been directed toward the fact that microvascular manifestations are perhaps the earliest signs of "cells and tissues" dysfunction in disease processes. The microvasculature undergoes a substantial remodeling not only in vascular wall structures, but also in network characteristics themselves especially in chronic disease. Those microvascular alterations in an organ system, which primarily originate in adaptations to the microenvironmental changes, would lead to the chronicity and self-perpetuation of disease. As has been noted in the IVth World Congress for Microcirculation organized by the Japanese Society for Microcirculation, which was held in Tokyo, July 26-30, 1987, further progress has been made in the research of organ microcirculation in the gastroenterological and other fields. It is the cornerstone for better understanding of the pathogenesis of organ diseases to clarify the earliest alterations in the microvasculature of an organ system from a combined aspect of microhemo- and microlymphocirculation using the newly developed techniques for microcirculation study.

  2. Targeting ECM Disrupts Cancer Progression.

    PubMed

    Venning, Freja A; Wullkopf, Lena; Erler, Janine T

    2015-01-01

    Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.

  3. Targeting ECM Disrupts Cancer Progression

    PubMed Central

    Venning, Freja A.; Wullkopf, Lena; Erler, Janine T.

    2015-01-01

    Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression. PMID:26539408

  4. Federal Facility Agreement progress report

    SciTech Connect

    Not Available

    1993-10-01

    The (SRS) Federal Facility Agreement (FFA) was made effective by the US. Environmental Protection Agency Region IV (EPA) on August 16, 1993. To meet the reporting requirements in Section XXV of the Agreement, the FFA Progress Report was developed. The FFA Progress Report is the first of a series of quarterly progress reports to be prepared by the SRS. As such this report describes the information and action taken to September 30, 1993 on the SRS units identified for investigation and remediation in the Agreement. This includes; rubble pits, runoff basins, retention basin, seepage basin, burning pits, H-Area Tank 16, and spill areas.

  5. IVS Organization

    NASA Technical Reports Server (NTRS)

    2004-01-01

    International VLBI Service (IVS) is an international collaboration of organizations which operate or support Very Long Baseline Interferometry (VLBI) components. The goals are: To provide a service to support geodetic, geophysical and astrometric research and operational activities. To promote research and development activities in all aspects of the geodetic and astrometric VLBI technique. To interact with the community of users of VLBI products and to integrate VLBI into a global Earth observing system.

  6. Organized DFM

    NASA Astrophysics Data System (ADS)

    Sato, Takashi; Honma, Michio; Itoh, Hiroyuki; Iriki, Nobuyuki; Kobayashi, Sachiko; Miyazaki, Norihiko; Onodera, Toshio; Suzuki, Hiroyuki; Yoshioka, Nobuyuki; Arima, Sumika; Kadota, Kazuya

    2009-04-01

    The category and objective of DFM production management are shown. DFM is not limited to an activity within a particular unit process in design and process. A new framework for DFM is required. DFM should be a total solution for the common problems of all processes. Each of them must be linked to one another organically. After passing through the whole of each process on the manufacturing platform, quality of final products is guaranteed and products are shipped to the market. The information platform is layered with DFM, APC, and AEC. Advanced DFM is not DFM for partial optimization of the lithography process and the design, etc. and it should be Organized DFM. They are managed with high-level organizational IQ. The interim quality between each step of the flow should be visualized. DFM will be quality engineering if it is Organized DFM and common metrics of the quality are provided. DFM becomes quality engineering through effective implementation of common industrial metrics and standardized technology. DFM is differential technology, but can leverage standards for efficient development.

  7. Organic superconductors

    NASA Astrophysics Data System (ADS)

    Jérome, D.

    1994-10-01

    The discovery of organic superconductors in 1980 was an happy conclusion of a search for high T c superconductors (although T c was modestly in the Kelvin range). The first generation of organic superconductors belonged to a large family of quasi-one-dimensional conducting cation radical salts. Most of them exhibit a wide range of new phenomena, including the competition between ground states, the influence of a magnetic field on the non ordered phase of a quasi-one-dimensional electron gas and the onset of spin density wave phases at high magnetic field with quantized Hall effect. The extensive study of the (TM) 2X series has shown that electron interactions are repulsive and of the order of the electron bandwidth. However, the nature of the ground states relies essentially on the balance between charge localisation boosted by the Umklapp scattering and the interchain hopping intergal. Second and third generation organic superconductors are two and three dimensional molecular conductors respectively with maximum T c of 12K (ET) 2X and 33 K (fullerides).

  8. Organic ternary solar cells: a review.

    PubMed

    Ameri, Tayebeh; Khoram, Parisa; Min, Jie; Brabec, Christoph J

    2013-08-21

    Recently, researchers have paid a great deal of attention to the research and development of organic solar cells, leading to a breakthrough of over 10% power conversion efficiency. Though impressive, further development is required to ensure a bright industrial future for organic photovoltaics. Relatively narrow spectral overlap of organic polymer absorption bands within the solar spectrum is one of the major limitations of organic solar cells. Among different strategies that are in progress to tackle this restriction, the novel concept of ternary organic solar cells is a promising candidate to extend the absorption spectra of large bandgap polymers to the near IR region and to enhance light harvesting in single bulk-heterojunction solar cells. In this contribution, we review the recent developments in organic ternary solar cell research based on various types of sensitizers. In addition, the aspects of miscibility, morphology complexity, charge transfer dynamics as well as carrier transport in ternary organic composites are addressed.

  9. [Domestic violence: any progress?].

    PubMed

    Henrion, Roger

    2014-01-01

    Since the publication of the French national survey of violence against women in 2000, the fight against domestic violence has made steady progress. Knowledge of the phenomenon has significantly improved. A nationwide study of murders and manslaughters perpetrated by one partner of a couple against the other has been published annually since 2006. In 2012, domestic violence resulted in the deaths of 314 persons: 166 women, 31 men, 25 children, 9 collateral victims, 14 rivals, and two former spouses killed by their ex-fathers in law. In addition, 67 perpetrators committed suicide (51 men and3 women). The number of victims fluctuates from year to year but has remained fairly stable since 2006 (n=168). Legislation has improved significantly: eight new laws have been passed since 2004, all designed to protect women and to ensure that violent men are restrained and treated. New measures to inform and protect women have been implemented and others have been improved, such as the anonymous helpline (phone no 3919, "domestic violence information"). An inter-ministerial committee on the protection of women from violence and the prevention of human trafficking (MIPROF) was created on 3 January 2013. A website entitled "Stop violence against women " (Stop violences faites aux femmes) is now available. The "Imminent Danger" mobile phone system, designed to alert police if a suspected or known perpetrator breaches restraint conditions, will be extended to the entire country from January 2014. Referees charged with coordinating comprehensive long-tern care of women victims have been deployed at the county level. Information centers on the rights of women and families (CIDFF) now form a local nationwide network. Routine interviews with a midwife during the fourth month of pregnancy, focusing on the woman's emotional, economic and social conditions, have been implemented in 21 % of maternity units and should gradually be generalized. The authorities who have enforced the law have

  10. Technical progress by major task. Semiannual technical progress report, September 29, 1997--March 29, 1998

    SciTech Connect

    1998-04-01

    The technical progress achieved during the period 29 September 1997 through 29 March 1998 on Contract DE-AC03-91SF18852 Radioisotope Thermoelectric Generators and Ancillary Activities is described in this report. The report is organized by program task structure: spacecraft integration and liaison; engineering support; safety; qualified unicouple production; RTG fabrication, assembly, and test; ground support equipment; RTG shipping and launch support; designs, reviews, and mission applications; project management, quality assurance, reliability, contract changes, CAGO acquisition (operating funds), and CAGO maintenance and repair.

  11. Public Attitudes to Technological Progress.

    ERIC Educational Resources Information Center

    Marshall, Eliot

    1979-01-01

    Discusses the probable changes in public attitudes toward science and technology as a result of the engineering accidents of 1979. Results of national polls conducted to identify public confidence in technological progress are included. (HM)

  12. Progress of the Productive Ward.

    PubMed

    Robert, Glenn

    The progress of the Productive Ward programme has been variable. This article outlines a study that investigated the experience of implementing the programme in different hospitals and the lessons that can be learnt.

  13. Arsenic | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  14. Home | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  15. Radon | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  16. Prevention | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  17. Introduction | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  18. Treatment | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  19. Diagnosis | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  20. Sunburn | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  1. Weight | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  2. Mortality | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  3. Survival | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  4. Incidence | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  5. Benzene | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  6. Acknowledgements | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  7. Nitrate | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  8. Cadmium | Cancer Trends Progress Report

    Cancer.gov

    The Cancer Trends Progress Report, first issued in 2001, summarizes our nation's advances against cancer in relation to Healthy People targets set forth by the Department of Health and Human Services.

  9. PREFACE: Progress in Nonequilibrium Green's Functions IV

    NASA Astrophysics Data System (ADS)

    Bonitz, Michael; Balzer, Karsten

    2010-04-01

    This is the fourth volume1 of articles on the theory of Nonequilibrium Green's functions (NEGF) and their modern application in various fields such as plasma physics, semiconductor physics, molecular electronics and high energy physics. It contains 23 articles written by experts in many-body theory and quantum transport who summarize recent progress in their respective area of research. The articles are based on talks given at the interdisciplinary conference Progress in Nonequilibrium Green's functions IV which was held 17-21 August 2009 at the University of Glasgow, Scotland. This conference continues the tradition of the previous meetings which started in 1999 and which aimed at an informal exchange across field boundaries. The previous meetings and the earlier proceedings proved to be very stimulating not only for young researchers but also for experienced scientists, and we are convinced that this fourth volume will be as successful as the previous ones. As before, this volume includes only extended review-type papers which are written in a way that they are understandable to a broad interdisciplinary audience. All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administrated by the Editors assuring highest scientific standards. In the review process some papers were substantially revised and improved and some were rejected. This conference would not have been possible without the remarkable work of the local organizing team around John Barker and Scott Roy and the generous financial support from the University of Glasgow and the Deutsche Forschungsgemeinschaft via SFB-Transregio 24. Michael Bonitz and Karsten Balzer Kiel, February 2010 1 The first two volumes are Progress in Nonequilibrium Green's functions, M Bonitz (ed) and Progress in Nonequilibrium Green's functions II, M Bonitz and D Semkat (eds), which were published by World Scientific (Singapore), in 2000 and 2003, respectively (ISBN

  10. Annual Progress report - General Task

    SciTech Connect

    Wesnousky, S.G.

    1993-09-30

    This report provides a summary of progress for the project {open_quotes}Evaluation of the Geologic Relations and Seismotectonic Stability of the Yucca Mountain Area, Nevada Nuclear Waste Site Investigation (NNWSI).{close_quotes} A similar report was previously provided for the period of 1 October 1991 to 30 September 1992. The report initially covers the activities of the General Task and is followed by sections that describe the progress of the other ongoing tasks.

  11. Monomelic amyotrophy with late progression.

    PubMed

    Rowin, J; Meriggioli, M N; Cochran, E J

    2001-04-01

    Monomelic amyotrophy is a sporadic juvenile-onset disease that presents with gradual onset of weakness and atrophy in the hand muscles unilaterally. Generally, this disease is considered a 'benign' and non-progressive motor neuron disease, which stabilizes within five years of onset. We discuss a case that illustrates that monomelic amyotrophy may rarely exhibit late clinical progression to the lower extremities after a prolonged period of disease stability.

  12. Scientific progress as increasing verisimilitude.

    PubMed

    Niiniluoto, Ilkka

    2014-06-01

    According to the foundationalist picture, shared by many rationalists and positivist empiricists, science makes cognitive progress by accumulating justified truths. Fallibilists, who point out that complete certainty cannot be achieved in empirical science, can still argue that even successions of false theories may progress toward the truth. This proposal was supported by Karl Popper with his notion of truthlikeness or verisimilitude. Popper's own technical definition failed, but the idea that scientific progress means increasing truthlikeness can be expressed by defining degrees of truthlikeness in terms of similarities between states of affairs. This paper defends the verisimilitude approach against Alexander Bird who argues that the "semantic" definition (in terms of truth or truthlikeness alone) is not sufficient to define progress, but the "epistemic" definition referring to justification and knowledge is more adequate. Here Bird ignores the crucial distinction between real progress and estimated progress, explicated by the difference between absolute (and usually unknown) degrees of truthlikeness and their evidence-relative expected values. Further, it is argued that Bird's idea of returning to the cumulative model of growth requires an implausible trick of transforming past false theories into true ones.

  13. 2012 ELECTRONIC PROCESSES IN ORGANIC MATERIALS GORDON RESEARCH SEMINAR, JUNE 2-8, 2012

    SciTech Connect

    Eisele, Dorthe

    2012-06-08

    This meeting focuses on the latest progress and challenges regarding organic electronics devices, artificial light-harvesting systems, and inorganic/organic hybrid nanoscale systems and especially on the synergy between these fields.

  14. Organic superconductors.

    PubMed

    Saito, Gunzi; Yoshida, Yukihiro

    2011-06-01

    The present status of organic superconductors of charge-transfer (CT) type based on donor molecules is reviewed. Along with the superconducting phases of such materials and also of oxide superconductors, reside spin-ordered phases such as spin-density wave (SDW) and antiferromagnetic (AF) phases. We briefly describe the recent development of superconductors having a superconducting phase next to a spin-disorder state (quantum spin liquid state). In addition to the CT type superconductors, there are a few single-component superconductors under high pressure.

  15. Magnetically retrievable catalysts for organic synthesis.

    PubMed

    Baig, R B Nasir; Varma, Rajender S

    2013-01-28

    The use of magnetic nanoparticles (MNPs) as a catalyst support in organic synthesis is summarized. The recovery of expensive catalysts after catalytic reaction and reusing them without losing their activity is an essential feature in the sustainable process development. The aim of this article is to highlight the progress in the synthesis and catalytic applications of magnetic catalysts in organic synthesis. The heterogenization of the catalyst using magnetic nanoparticles allows it to be recovered and reused using an external magnet.

  16. Contractor Logistics Support in the U.S. Air Force

    DTIC Science & Technology

    2009-01-01

    the Sacramento ALC at McClellan AFB . After the BRAC Commission voted in FY 1995 to close McClellan , the Air Force chose CLS for the F-117. The... Sacramento ALC at McClellan AFB would also have been the depot for the F-22. The original sustainment plan for organic sup- port was premised on a fleet of...major depots until the Base Realignment and Closure (BRAC) Commission in 1995 recommended closure of two ALCs.1 Kelly and McClellan AFBs closed in

  17. Defining secondary progressive multiple sclerosis.

    PubMed

    Lorscheider, Johannes; Buzzard, Katherine; Jokubaitis, Vilija; Spelman, Tim; Havrdova, Eva; Horakova, Dana; Trojano, Maria; Izquierdo, Guillermo; Girard, Marc; Duquette, Pierre; Prat, Alexandre; Lugaresi, Alessandra; Grand'Maison, François; Grammond, Pierre; Hupperts, Raymond; Alroughani, Raed; Sola, Patrizia; Boz, Cavit; Pucci, Eugenio; Lechner-Scott, Jeanette; Bergamaschi, Roberto; Oreja-Guevara, Celia; Iuliano, Gerardo; Van Pesch, Vincent; Granella, Franco; Ramo-Tello, Cristina; Spitaleri, Daniele; Petersen, Thor; Slee, Mark; Verheul, Freek; Ampapa, Radek; Amato, Maria Pia; McCombe, Pamela; Vucic, Steve; Sánchez Menoyo, José Luis; Cristiano, Edgardo; Barnett, Michael H; Hodgkinson, Suzanne; Olascoaga, Javier; Saladino, Maria Laura; Gray, Orla; Shaw, Cameron; Moore, Fraser; Butzkueven, Helmut; Kalincik, Tomas

    2016-09-01

    A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis, to enable comparability of future research studies. Using MSBase, a large, prospectively acquired, global cohort study, we analysed the accuracy of 576 data-derived onset definitions for secondary progressive multiple sclerosis and first compared these to a consensus opinion of three neurologists. All definitions were then evaluated against 5-year disease outcomes post-assignment of secondary progressive multiple sclerosis: sustained disability, subsequent sustained progression, positive disability trajectory, and accumulation of severe disability. The five best performing definitions were further investigated for their timeliness and overall disability burden. A total of 17 356 patients were analysed. The best definition included a 3-strata progression magnitude in the absence of a relapse, confirmed after 3 months within the leading Functional System and required an Expanded Disability Status Scale step ≥4 and pyramidal score ≥2. It reached an accuracy of 87% compared to the consensus diagnosis. Seventy-eight per cent of the identified patients showed a positive disability trajectory and 70% reached significant disability after 5 years. The time until half of all patients were diagnosed was 32.6 years (95% confidence interval 32-33.6) after disease onset compared with the physicians' diagnosis at 36 (35-39) years. The identified patients experienced a greater disease burden [median annualized area under the disability-time curve 4.7 (quartiles 3.6, 6.0)] versus non-progressive patients [1.8 (1.2, 1.9)]. This objective definition of secondary progressive multiple

  18. Effect of morphology on organic thin film transistor sensors.

    PubMed

    Locklin, Jason; Bao, Zhenan

    2006-01-01

    This review provides a general introduction to organic field-effect transistors and their application as chemical sensors. Thin film transistor device performance is greatly affected by the molecular structure and morphology of the organic semiconductor layer. Various methods for organic semiconductor deposition are surveyed. Recent progress in the fabrication of organic thin film transistor sensors as well as the correlation between morphology and analyte response is discussed.

  19. Progress in reforming chemical engineering education.

    PubMed

    Wankat, Phillip C

    2013-01-01

    Three successful historical reforms of chemical engineering education were the triumph of chemical engineering over industrial chemistry, the engineering science revolution, and Engineering Criteria 2000. Current attempts to change teaching methods have relied heavily on dissemination of the results of engineering-education research that show superior student learning with active learning methods. Although slow dissemination of education research results is probably a contributing cause to the slowness of reform, two other causes are likely much more significant. First, teaching is the primary interest of only approximately one-half of engineering faculty. Second, the vast majority of engineering faculty have no training in teaching, but trained professors are on average better teachers. Significant progress in reform will occur if organizations with leverage-National Science Foundation, through CAREER grants, and the Engineering Accreditation Commission of ABET-use that leverage to require faculty to be trained in pedagogy.

  20. [Research progress on biochar carbon sequestration technology].

    PubMed

    Jiang, Zhi-Xiang; Zheng, Hao; Li, Feng-Min; Wang, Zhen-Yu

    2013-08-01

    Biochar is a fine-grained and porous material, which is produced by pyrolyzing biomass under anaerobic or oxygen-limiting condition. Due to the aromatic structure, it is resistant to the biotic and abiotic degradation which makes biochar production a promising carbon sequestration technology, and it has attracted widespread attention. Factors including biochar production, biochar stability in soil and the response of plant growth and soil organic carbon to the biochar addition can influence the carbon sequestration potential of biochar. Through exploring the mechanisms of biochar carbon sequestration, the influence of these factors was studied. Furthermore, the research progress of carbon sequestration potential and its economic viability were examined. Finally, aiming at the knowledge gaps in the influencing factors as well as the relationship between these factors, some further research needs were proposed for better application of biochar in China.

  1. Acute Pancreatitis—Progress and Challenges

    PubMed Central

    Afghani, Elham; Pandol, Stephen J.; Shimosegawa, Tooru; Sutton, Robert; Wu, Bechien U.; Vege, Santhi Swaroop; Gorelick, Fred; Hirota, Morihisa; Windsor, John; Lo, Simon K.; Freeman, Martin L.; Lerch, Markus M.; Tsuji, Yoshihisa; Melmed, Gil Y.; Wassef, Wahid; Mayerle, Julia

    2016-01-01

    An international symposium entitled “Acute pancreatitis: progress and challenges” was held on November 5, 2014 at the Hapuna Beach Hotel, Big Island, Hawaii, as part of the 45th Anniversary Meeting of the American Pancreatic Association and the Japanese Pancreas Society. The course was organized and directed by Drs. Stephen Pandol, Tooru Shimosegawa, Robert Sutton, Bechien Wu, and Santhi Swaroop Vege. The symposium objectives were to: (1) highlight current issues in management of acute pancreatitis, (2) discuss promising treatments, (3) consider development of quality indicators and improved measures of disease activity, and (4) present a framework for international collaboration for development of new therapies. This article represents a compilation and adaptation of brief summaries prepared by speakers at the symposium with the purpose of broadly disseminating information and initiatives. PMID:26465949

  2. [Photoprotective mechanisms of leaf anthocyanins: research progress].

    PubMed

    Wang, Liang-Zai; Hu, Yan-Bo; Zhang, Hui-Hui; Xu, Nan; Zhang, Xiu-Li; Sun, Guang-Yu

    2012-03-01

    Anthocyanin is widely distributed in plant organs such as root, stem, leaf, flower and fruit, being a kind of secondary metabolites generated in plant morphogenesis or for stress response. Leaf anthocyanin has special chemical structure and spectral properties, playing important roles in plant photoprotection, and becomes a hotspot in plant photosynthetic physiological ecology. This paper summarized the recent research progress in the effects of leaf anthocyanin on plant photosynthesis, including the distribution of leaf anthocyanin, its spectral properties, and its relationships with photosynthetic pigments, with the focus on the potential mechanisms of anthocyanins photoprotection, including light absorption, antioxidation, and osmotic regulation. The further research directions on the effects of leaf anthocyanin on photoprotection were proposed.

  3. [Progress on biogas technology and engineering].

    PubMed

    Liu, Xiaofeng; Yuan, Yuexiang; Yan, Zhiying

    2010-07-01

    Dwindling supplies of conventional energy sources and the demand to increase the share of renewable energy for sustainability have increased the significance of biogas, the product of synergistic fermentation of biodegrable organic wastes from municipal, agricultural and industrial activities by microbial populations under anaerobic conditions. With extensive research and engineering practice, many technologies and modes have been developed for biogas production and application. Currently, the most widely used mode is the complete-mixing mesophilic fermentation. Europe, especially Germany, is leading the world in the combined heat and power production (CHP) from biogas. In this paper, updated progress in biogas technologies is reviewed, with focuses on anaerobic microorganisms, bioreactor configurations and process development, biogas production and applications, in which perspectives of biogas as a clean and renewable energy are projected.

  4. The 1990 progress report and future plans

    NASA Technical Reports Server (NTRS)

    Friedland, Peter; Zweben, Monte; Compton, Michael

    1990-01-01

    This document describes the progress and plans of the Artificial Intelligence Research Branch (RIA) at ARC in 1990. Activities span a range from basic scientific research to engineering development and to fielded NASA applications, particularly those applications that are enabled by basic research carried out at RIA. Work is conducted in-house and through collaborative partners in academia and industry. Our major focus is on a limited number of research themes with a dual commitment to technical excellence and proven applicability to NASA short, medium, and long-term problems. RIA acts as the Agency's lead organization for research aspects of artificial intelligence, working closely with a second research laboratory at JPL and AI applications groups at all NASA centers.

  5. Bioethics: why philosophy is essential for progress.

    PubMed

    Savulescu, Julian

    2015-01-01

    It is the JME's 40th anniversary and my 20th anniversary working in the field. I reflect on the nature of bioethics and medical ethics. I argue that both bioethics and medical ethics together have, in many ways, failed as fields. My diagnosis is that better philosophy is needed. I give some examples of the importance of philosophy to bioethics. I focus mostly on the failure of ethics in research and organ transplantation, although I also consider genetic selection, enhancement, cloning, futility, disability and other topics. I do not consider any topic comprehensively or systematically or address the many reasonable objections to my arguments. Rather, I seek to illustrate why philosophical analysis and argument remain as important as ever to progress in bioethics and medical ethics.

  6. The Organic Solid State.

    ERIC Educational Resources Information Center

    Cowan, Dwaine O.; Wlygul, Frank M.

    1986-01-01

    Reviews interesting and useful electrical, magnetic, and optical properties of the organic solid state. Offers speculation as to areas of fruitful research. Discusses organic superconductors, conducting organic polymers, organic metals, and traces recent history of creation of organic metals. (JM)

  7. The State of Organic Teaching Laboratories

    ERIC Educational Resources Information Center

    Horowitz, Gail

    2007-01-01

    The changes that have taken place in the organic chemistry laboratory course since 1980s are reviewed with reference to the quantity and diversity of discovery-based experiments available to date. The data illustrates that significant progress is towards accomplishing dramatic changes such as the almost universal adoption of microscale, the use of…

  8. The Spaces and Ethics of Organic Food

    ERIC Educational Resources Information Center

    Clarke, Nick; Cloke, Paul; Barnett, Clive; Malpass, Alice

    2008-01-01

    Initial assessments of the potential for organic food systems have offered an optimistic interpretation of the progressive political and ethical characteristics involved. This positive gloss has prompted a stream of critique emphasising the need to explore the ambiguities and disconnections inherent therein. In this paper, we consider the case of…

  9. Systematics and evolution of Heteroptera: 25 years of progress.

    PubMed

    Weirauch, Christiane; Schuh, Randall T

    2011-01-01

    Heteroptera, or true bugs, are part of the most successful radiation of nonholometabolous insects. Twenty-five years after the first review on the influence of cladistics on systematic research in Heteroptera, we summarize progress, problems, and future directions in the field. The few hypotheses on infraordinal relationships conflict on crucial points. Understanding relationships within Gerromorpha, Nepomorpha, Leptopodomorpha, Cimicomorpha, and Pentatomomorpha is improving, but progress within Enicocephalomorpha and Dipsocoromorpha is lagging behind. Nonetheless, the classifications of several superfamily-level taxa within the Pentatomomorpha, such as Aradoidea, Coreoidea, and Pyrrhocoroidea, are still unaffected by cladistic studies. Progress in comparative morphology is slow and drastically impedes our understanding of the evolution of major clades. Molecular systematics has dramatically contributed to accelerating the generation and testing of hypotheses. Given the fascinating natural history of true bugs and their status as model organisms for evolutionary studies, integration of cladistic analyses in a broader biogeographic and evolutionary context deserves increased attention.

  10. Progressive Multifocal Leukoencephalopathy in Transplant Recipients

    PubMed Central

    Mateen, Farrah J.; Muralidharan, RajaNandini; Carone, Marco; van de Beek, Diederik; Harrison, Daniel M.; Aksamit, Allen J.; Gould, Mary S.; Clifford, David B.; Nath, Avindra

    2016-01-01

    Objective Transplant recipients are at risk of developing progressive multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction by JC virus. Methods Reports of PML following transplantation were found using PubMed Entrez (1958–July 2010). A multicenter, retrospective cohort study also identified all cases of PML among transplant recipients diagnosed at Mayo Clinic, Johns Hopkins University, Washington University, and Amsterdam Academic Medical Center. At 1 institution, the incidence of posttransplantation PML was calculated. Results A total of 69 cases (44 solid organ, 25 bone marrow) of posttransplantation PML were found including 15 from the 4 medical centers and another 54 from the literature. The median time to development of first symptoms of PML following transplantation was longer in solid organ vs bone marrow recipients (27 vs 11 months, p = 0.0005, range of <1 to >240). Median survival following symptom onset was 6.4 months in solid organ vs 19.5 months in bone marrow recipients (p = 0.068). Case fatality was 84% (95% confidence interval [CI], 70.3–92.4%) and survival beyond 1 year was 55.7% (95% CI, 41.2–67.2%). The incidence of PML among heart and/or lung transplant recipients at 1 institution was 1.24 per 1,000 posttransplantation person-years (95% CI, 0.25–3.61). No clear association was found with any 1 immunosuppressant agent. No treatment provided demonstrable therapeutic benefit. Interpretation The risk of PML exists throughout the posttransplantation period. Bone marrow recipients survive longer than solid organ recipients but may have a lower median time to first symptoms of PML. Posttransplantation PML has a higher case fatality and may have a higher incidence than reported in human immunodeficiency virus (HIV) patients on highly-active antiretroviral therapy (HAART) or multiple sclerosis patients treated with natalizumab. PMID:21823157

  11. Challenges for Production of Human Transplantable Organ Grafts

    PubMed Central

    Kobayashi, Eiji

    2017-01-01

    The described research methods explain how you could generate a three-dimensional kidney, based on recent research results. The first method is to fabricate human organs in a pig body. The second is to transplant the so-called “organ bud” into a patient’s body for further development. The third method is to regenerate organs by filling cells into the cytoskeleton as a scaffold. Research for the in vitro fabrication of organ buds has been elaborately accelerated. The organ bud transplantation has been confronted with issues of continuity with the original organs, so the development of technology for achieving continuity between a transplanted organ bud and the existing organs is progressing well. The “organ fabrication” methodology, whereby cells are placed into completely decellularized organs, is supported by recent research results using pig organs taking the size of humans into consideration. PMID:28174670

  12. Commission on the Future of Howard Community College Progress Report, 2001.

    ERIC Educational Resources Information Center

    Howard Community Coll., Columbia, MD. Office of Planning and Evaluation.

    This Howard Community College (HCC) (Maryland) 2001 Progress Report makes assessments and recommendations in the following areas: (1) creating a world class learning organization; (2) collaboration with other educational organizations; (3) collaboration with business and industry; (4) economics and workforce development; (5) preparing students as…

  13. Advances in organic transistor-based biosensors: from organic electrochemical transistors to electrolyte-gated organic field-effect transistors.

    PubMed

    Kergoat, Loïg; Piro, Benoît; Berggren, Magnus; Horowitz, Gilles; Pham, Minh-Chau

    2012-02-01

    Organic electronics have, over the past two decades, developed into an exciting area of research and technology to replace classic inorganic semiconductors. Organic photovoltaics, light-emitting diodes, and thin-film transistors are already well developed and are currently being commercialized for a variety of applications. More recently, organic transistors have found new applications in the field of biosensors. The progress made in this direction is the topic of this review. Various configurations are presented, with their detection principle, and illustrated by examples from the literature.

  14. Clinical management of progressive myopia

    PubMed Central

    Aller, T A

    2014-01-01

    Myopia has been increasing in prevalence throughout the world, reaching over 90% in some East Asian populations. There is increasing evidence that whereas genetics clearly have an important role, the type of visual environment to which one is exposed to likely influences the onset, progression, and cessation of myopia. Consequently, attempts to either modify the environment or to reduce the exposure of the eye to various environmental stimuli to eye growth through the use of various optical devices are well under way at research centers around the globe. The most promising of current treatments include low-percentage atropine, bifocal soft contact lenses, orthokeratology, and multifocal spectacles. These methods are discussed briefly and are then categorized in terms of their expected degree of myopia progression control. A clinical strategy is presented for selecting the most effective treatment for the appropriate type of patient at the optimal stage of refractive development to achieve the maximum control of myopia progression. PMID:24357844

  15. Optics of progressive addition lenses.

    PubMed

    Sheedy, J E; Buri, M; Bailey, I L; Azus, J; Borish, I M

    1987-02-01

    The optical characteristics of the major progressive addition lenses were measured using an automated lensometer with a specially designed lens holder to simulate eye rotation. Measurements were made every 3 degrees (about 1.5 mm) and graphs of isospherical equivalent lines and isocylinder lines were developed. Generally the near zone of these lenses is narrower and lower than in bifocal or trifocal lenses. Distinct differences exist between the various progressive lenses. The width of the near zone, rate of power progression, amount of unwanted cylinder (level with the distance center), and clarity of the distance zone are compared for the various lenses. The optical measurements demonstrate an apparent trade-off between the size of the cylinder-free area of the lens and the amount of the cylinder.

  16. Superfund progress. Aficionado's version. Progress as of September 30, 1992

    SciTech Connect

    Not Available

    1993-01-01

    The issue of Superfund Progress Aficionado's Version provides facts and figures as of September 30, 1992, for NPL site distribution, emergency removals, preliminary assessments/site inspections/the NPL, remedial investigations/feasibility studies/RODs, remedial action, and enforcement.

  17. Thematic Progression in a Cardiologist's Text: Context, Frames and Progression.

    ERIC Educational Resources Information Center

    Salter, Robert T.

    Thematic progression (TP) is examined in the text of a communication between a cardiologist and a general practitioner concerning a patient, offering a clinical diagnosis of the patient's condition. Analysis of the discourse looks at the field, tenor, and mode of the communication as a context for TP. The methods of analysis are first described,…

  18. Measuring Progressions: Assessment Structures Underlying a Learning Progression

    ERIC Educational Resources Information Center

    Wilson, Mark

    2009-01-01

    This article describes some of the underlying conceptualizations that have gone into the work of the BEAR Center in the development of learning progressions. The core of all of these developments has been the construct map, which is the first building block in the BEAR Assessment System (BAS). After introducing the concept of a learning…

  19. [Can we accept medical progress without progress in ethics?].

    PubMed

    Benaroyo, Lazare

    2013-01-01

    Since the mid 20th century progress in biomedical science has been punctuated by the emergence of bioethics which has fashioned the moral framework of its application to both research and clinical practice. Can we, however, consider the advent of bioethics as a form of progress marking the advances made in biomedical science with an adequate ethical stamp? The argument put forward in this chapter is based on the observation that, far from being a mark of progess, the development of bioethics runs the risk of favouring, like modern science, a dissolution of the links that unite ethics and medicine, and so of depriving the latter of the humanist dimensions that underlie the responsibilities that fall to it. Faced with this possible pitfall, this contribution proposes to envisage as a figure of moral progress, consubstantial with the development of biomedical science, an ethical approach conceived as a means of social intervention which takes the first steps towards an ethics of responsibility integrating the bioethical perspective within a hermeneutic and deliberative approach. By the yardstick of a prudential approach, it would pay particular attention to the diverse sources of normativity in medical acts. It is suggested that this ethical approach is a source of progress insofar as it constitutes an indispensable attitude of watchfulness, which biomedical science can lean on as it advances, with a view to ensuring that the fundamental link uniting ethics and medicine is maintained.

  20. Progress Report NORSAR Phase 3

    DTIC Science & Technology

    1975-04-11

    1 A I)-A 010 5 86 PROGRriSS REPORT NORSAR PHASE 3 K . /\\ . B c r t c u s s e n Royal Norwegian Council for Scientific and...NORSAR ROYAl NORWEGIAN COUNCIL FOR SCIENTIFIC AND INDUSTRIAL RESEARCH <o<: 00 10’ o H O < F 8606-74-C-0049 PROGRESS REPORT - NORSAR PHASE 3 1...Report NORSAR Phase 3 1st Quarter 1975 5 TYPE OE REPORT « PERIOD COVERED Progress Report 1st Quarter 1975 6 PERFORMING ORG

  1. Shuttle Risk Progression by Flight

    NASA Technical Reports Server (NTRS)

    Hamlin, Teri; Kahn, Joe; Thigpen, Eric; Zhu, Tony; Lo, Yohon

    2011-01-01

    Understanding the early mission risk and progression of risk as a vehicle gains insights through flight is important: . a) To the Shuttle Program to understand the impact of re-designs and operational changes on risk. . b) To new programs to understand reliability growth and first flight risk. . Estimation of Shuttle Risk Progression by flight: . a) Uses Shuttle Probabilistic Risk Assessment (SPRA) and current knowledge to calculate early vehicle risk. . b) Shows impact of major Shuttle upgrades. . c) Can be used to understand first flight risk for new programs.

  2. Biogas Opportunities Roadmap Progress Report

    SciTech Connect

    None, None

    2015-12-01

    In support of the Obama Administration's Climate Action Plan, the U.S. Department of Energy, the U.S. Environmental Protection Agency, and U.S. Department of Agriculture jointly released the Biogas Opportunities Roadmap Progress Report, updating the federal government's progress to reduce methane emissions through biogas systems since the Biogas Opportunities Roadmap was completed by the three agencies in July 2014. The report highlights actions taken, outlines challenges and opportunities, and identifies next steps to the growth of a robust biogas industry.

  3. Recent progress on intrinsic charm

    NASA Astrophysics Data System (ADS)

    Hobbs, T. J.

    2017-03-01

    Over the past ˜10 years, the topic of the nucleon's nonperturbative or intrinsic charm (IC) content has enjoyed something of a renaissance, largely motivated by theoretical developments involving quark modelers and PDF-fitters. In this talk I will briefly describe the importance of intrinsic charm to various issues in high-energy phenomenology, and survey recent progress in constraining its overall normalization and contribution to the momentum sum rule of the nucleon. I end with the conclusion that progress on the side of calculation has now placed the onus on experiment to unambiguously resolve the proton's intrinsic charm component.

  4. Assessment of Child Progress. Monograph Number 2.

    ERIC Educational Resources Information Center

    Danaher, Joan, Ed.

    Four author-contributed papers examine issues in assessing child progress in early childhood special education. D. Bricker and S. Gumerlock present "A Three-Level Strategy" which features analysis of daily or weekly progress, analysis of progress toward long- and short-term objectives, and analysis of progress toward program goals. C. Dunst…

  5. Deactivation of Building 7602

    SciTech Connect

    Yook, H.R.; Barnett, J.R.; Collins, T.L.

    1995-10-01

    The Department of Energy (DOE) has sponsored research and development programs in Building 7602 at Oak Ridge National Laboratory (ORNL) since 1984. This work focused on development of advanced technology for processing nuclear fuels. Building 7602 was used for engineering-scale tests using depleted and natural uranium to simulate the nuclear fuel. In April 1994 the DOE Office of Nuclear Energy (NE) sent supplemental FY 1994 guidance to ORNL stating that in FY 1995 and beyond, Building 7602 is considered surplus to NE programs and missions and shall be shut down (deactivated) and maintained in a radiologically and industrially safe condition with minimal surveillance and maintenance (S&M). DOE-NE subsequently provided FY 1995 funding to support the deactivation activities. Deactivation of Building 7602 was initiated on October 1, 1994. The principal activity during the first quarter of FY 1995 was removal of process materials (chemicals and uranium) from the systems. The process systems were operated to achieve chemical solution concentrations needed for reuse or disposal of the solutions prior to removal of the materials from the systems. During this phase of deactivation the process materials processed and removed were: (1) Uranyl nitrate solution 30,178 L containing 4490 kg of uranium; (2) Nitric acid (neutralized) 9850 L containing less than 0.013 kg of uranium; (3) Organic solution 3346 L containing 265 kg of uranium; (4) Uranium oxide powder 95 kg; and (5) Miscellaneous chemicals. At the end of December 1994, the process systems and control systems were shut down and deactivated. Disposition of the process materials removed from the process systems in Building 7602 proved to be the most difficult part of the deactivation. An operational stand down and funding reductions at Y-12 prevented planned conversion of the uranyl nitrate solution to depleted uranium oxide powder. This led to disposal of the uranyl nitrate solution as waste.

  6. Recent progress in hydrothermal synthesis of zinc oxide nanomaterials.

    PubMed

    Djurisic, A B; Chen, X Y; Leung, Y H

    2012-06-01

    Hydrothermal synthesis is of considerable interest due to its low cost, simplicity and relatively low growth temperature (typically below 200 °C). Since the synthesis is performed in aqueous solutions (no organic solvents), it can also be safe and environmentally friendly (depending on precursor chemicals). Consequently, it has been a subject of intense research in recent years. In this article, we review recent progress in hydrothermal synthesis of zinc oxide nanomaterials, with focus on practical relevance for a variety of applications.

  7. Nuclear waste management. Quarterly progress report, October-December 1979

    SciTech Connect

    Platt, A.M.; Powell, J.A.

    1980-04-01

    Progress and activities are reported on the following: high-level waste immobilization, alternative waste forms, nuclear waste materials characterization, TRU waste immobilization programs, TRU waste decontamination, krypton solidification, thermal outgassing, iodine-129 fixation, monitoring of unsaturated zone transport, well-logging instrumentation development, mobile organic complexes of fission products, waste management system and safety studies, assessment of effectiveness of geologic isolation systems, waste/rock interactions technology, spent fuel and fuel pool integrity program, and engineered barriers. (DLC)

  8. Organic electronics: the endless frontier (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Kippelen, Bernard

    2016-10-01

    In this talk, we will discuss recent progress in a range of solid-state devices, including organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs), sensors, organic solar cells, and photodetectors. We will present strategies to modify and stabilize the electronic properties of interfaces that can yield devices with improved performance and longer lifetime. Examples of recent studies to reduce the environmental footprint of this emerging technology will be provided. We will show that these advances can lead to disruptive innovations to address some of the world's greatest challenges.

  9. Multifunctional Metal-Organic Frameworks for Photocatalysis.

    PubMed

    Wang, Sibo; Wang, Xinchen

    2015-07-01

    Metal-organic frameworks (MOFs) have attracted significant research attention in diverse areas due to their unique physical and chemical characteristics that allow their innovative application in various research fields. Recently, the application of MOFs in heterogeneous photocatalysis for water splitting, CO2 reduction, and organic transformation have emerged, aiming at providing alternative solutions to address the world-wide energy and environmental problems by taking advantage of the unique porous structure together with ample physicochemical properties of the metal centers and organic ligands in MOFs. In this review, the latest progress in MOF-involved solar-to-chemical energy conversion reactions are summarized according to their different roles in the photoredox chemical systems, e.g., photocatalysts, co-catalysts, and hosts. The achieved progress and existing problems are evaluated and proposed, and the opportunities and challenges of MOFs and their related materials for their advanced development in photocatalysis are discussed and anticipated.

  10. Progress Update: Stack Project Complete

    ScienceCinema

    Cody, Tom

    2016-07-12

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  11. Progressive Paraparesis after CABG Surgery

    PubMed Central

    Shadvar, Kamran; Eslampoor, Yashar

    2013-01-01

    CABG is one of the most common cardiac surgeries all over the world. Similar to other surgeries, it may be associated with some undesirable complications including neurologic complications which might cause morbidity and mortality after surgery. We will describe a case of Progressive Paraparesis after CABG Surgery and review its etiology, diagnosis and management. PMID:24251008

  12. HARVARD PROJECT PHYSICS PROGRESS REPORT.

    ERIC Educational Resources Information Center

    Harvard Univ., Cambridge, MA.

    THIS REPORT OF HARVARD PROJECT PHYSICS PRESENTS DRAFTS OF THREE SPEECHES DELIVERED TO THE AMERICAN ASSOCIATION OF PHYSICS TEACHERS (AAPT) MEETING, FEBRUARY, 1967. THE ADDRESS BY GERALD HOLTON DEALS WITH THE AIMS AND PROGRESS OF THE PROJECT. DISCUSSED ARE (1) PROJECT PARTICIPANTS, (2) AIMS AND CONTENT, (3) THE NEW EMPHASIS, (4) SURVEY OF COURSE…

  13. Grassroots Excellence: Problems and Progress.

    ERIC Educational Resources Information Center

    Hansen, Kenneth H.

    The educational "excellence" movement is hindered by inconsistencies between goals and action and by difficulties in translating national and state goals into local policy; nonetheless, progress has occurred. Examples of "voodoo excellence," in which proposed policies will likely work against their stated objectives, are…

  14. Minority Student Progress Report, 1991.

    ERIC Educational Resources Information Center

    Diaz, Porfirio R.; Luan, Jing

    This report offers a consolidated systemwide analysis of key issues and recommendations for improvement of minority recruitment and retention at Arizona State Universities and an evaluation of progress toward achieving Arizona Board of Regents (ABOR) approved recruitment and graduation goals. A description of ABOR system goals notes three goals:…

  15. Myopia: attempts to arrest progression

    PubMed Central

    Saw, S M; Gazzard, G; Au Eong, K-G; Tan, D T H

    2002-01-01

    Previous studies have evaluated the efficacy of several interventions to decrease the progression of myopia. These include devices that alter the perception of the visual environment and pharmacological treatments. There is no conclusive evidence thus far that alteration of the pattern of spectacle wear, bifocals, ocular hypotensives, or contact lenses retards the progression of myopia. Several randomised clinical trials have demonstrated that the rate of progression of myopia is lower in children given atropine eye drops than those given placebo. However, atropine is associated with short term side effects such as photophobia and possible long term adverse events including light induced retinal damage and cataract formation. Other more selective antimuscarinic agents such as pirenzipine are presently being evaluated. Further well conducted randomised clinical trials with large sample sizes and adequate follow up designed to evaluate treatments to retard the progression of myopia should be conducted, since the identification of an effective intervention may have a greater public health impact on the burden and morbidity from myopia than the few treatments currently available. PMID:12386095

  16. Katrina's progress with learning mathematics.

    PubMed

    McConnochie, Jan; Sneath, Greg

    2007-07-01

    Katrina is 10 years old and has Down syndrome. She is making good progress with learning and numbers and mathematics. We describe how Katrina has learned number concepts and arithmetic skills over several years. We highlight the influence of early learning habits, visual supports, motivation and practice, and the uses made of different number teaching schemes.

  17. Solar Energy: Progress and Promise.

    ERIC Educational Resources Information Center

    Council on Environmental Quality, Washington, DC.

    This report discusses many of the economic and policy questions related to the widespread introduction of solar power, presents recent progress in developing solar technologies and advancing their economic feasibility, and reviews some recommendations that have been made for achieving the early introduction and sustained application of solar…

  18. Continuous Progress and Nongraded Schools.

    ERIC Educational Resources Information Center

    Cox, June

    1983-01-01

    Four schools offering a continuous progress or nongraded approach to pacing for gifted students are reviewed: the Plano (TX) Independent School District, The University of Pittsburgh Laboratory School, the Chesapeake (VA) Demonstration School, and the University of California at Los Angeles Elementary School. (CL)

  19. Progress Update: Stack Project Complete

    SciTech Connect

    Cody, Tom

    2010-01-01

    Progress update from the Savannah River Site. The 75 foot 293 F Stack, built for plutonium production, was cut down to size in order to prevent injury or release of toxic material if the structure were to collapse due to harsh weather.

  20. Assessing Pupils' Progress in Science

    ERIC Educational Resources Information Center

    Slade, Peter

    2009-01-01

    Good assessment practice is a fundamental part of good teaching and learning. It puts learners at the heart of the process, helping them to recognise achievement and make progress, and enables teachers to shape and adapt their teaching to individual needs and aspirations. Over the past year, the Qualifications and Curriculum Authority (QCA) has…

  1. Progress in semiconductor drift detectors

    SciTech Connect

    Rehak, P.; Walton, J.; Gatti, E.; Longoni, A.; Sanpietro, M.; Kemmer, J.; Dietl, H.; Holl, P.; Klanner, R.; Lutz, G.

    1985-01-01

    Progress in testing semiconductor drift detectors is reported. Generally better position and energy resolutions were obtained than resolutions published previously. The improvement is mostly due to new electronics better matched to different detectors. It is shown that semiconductor drift detectors are becoming versatile and reliable detectors for position and energy measurements.

  2. Progressive transmission and compression images

    NASA Technical Reports Server (NTRS)

    Kiely, A. B.

    1996-01-01

    We describe an image data compression strategy featuring progressive transmission. The method exploits subband coding and arithmetic coding for compression. We analyze the Laplacian probability density, which closely approximates the statistics of individual subbands, to determine a strategy for ordering the compressed subband data in a way that improves rate-distortion performance. Results are presented for a test image.

  3. Significant Ideas and Progressive Change

    ERIC Educational Resources Information Center

    Morgan, Gwen; Mitchell, Anne

    2012-01-01

    Ideas are not one-time "Eureka" moments, but are parts of concepts progressing forward. Sometimes years pass before ideas are implemented. They then resurface, connect with other ideas, and move policies ahead. Meanwhile, the idea remains alive in the field, influencing decisions and goals. Ideas build on one another when implemented. The field of…

  4. Measuring research progress in photovoltaics

    NASA Technical Reports Server (NTRS)

    Jackson, B.; Mcguire, P.

    1986-01-01

    The role and some results of the project analysis and integration function in the Flat-plate Solar Array (FSA) Project are presented. Activities included supporting the decision-making process, preparation of plans for project direction, setting goals for project activities, measuring progress within the project, and the development and maintenance of analytical models.

  5. Canadian ERTS program progress report

    NASA Technical Reports Server (NTRS)

    Morley, L. W.; Mcquillan, A. K.

    1974-01-01

    Progress of the Canadian ERTS program is provided along with statistics on the production and role of ERTS images both from the CCRS in Ottawa and from the Prince Albert Saskatchewan satellite station. The types of products, difficulties of production and some of the main applications in Canada are discussed.

  6. MRFM System Design for the Study of Organic Materials

    NASA Astrophysics Data System (ADS)

    Smith, Doran; Kim, David

    2007-03-01

    We will present an overview of our program to develop an MRFM system specialized for the study of organic materials at 4 K. The system uses the SPAM geometry and the CERMIT protocol and is predicted to be capable of imaging organic materials in 3D. The MRFM probe head design will be overviewed and progress toward system completion will be discussed.

  7. The future of organic photovoltaics.

    PubMed

    Mazzio, Katherine A; Luscombe, Christine K

    2015-01-07

    Increasing global demand for energy, along with dwindling fossil fuel resources and a better understanding of the hidden costs associated with these energy sources, have spurred substantial political, academic, and industrial interest in alternative energy resources. Photovoltaics based on organic semiconductors have emerged as promising low-cost alternatives for electricity generation that relies on sunlight. In this tutorial review we discuss the relevance of these organic photovoltaics beginning with some of the economic drivers for these technologies. We then examine the basic properties of these devices, including operation and materials requirements, in addition to presenting the development of the field from a historical perspective. Potential future directions are also briefly discussed. This tutorial review is intended to be an essential overview of the progress of the field, in addition to aiding in the discussion of the future of OPV technologies.

  8. Progress?

    NASA Astrophysics Data System (ADS)

    Scientists who were once protected by the hammer and sickle are now being bludgeoned with them, according to a report published in November by the American Association for the Advancement of Science (AAAS). Thousands of scientists, professors, and science teachers who had been affiliated with the communist regimes of Central and Eastern European nations are being purged from academic institutions under the premise of righting a perceived historical wrong.More than 3,000 scientists in Bulgaria, as well as 884 university professors and 10,000 teachers in the German state of Saxony, have lost their jobs in the past 5 years. Nearly 6% of all Czech faculty members also have been fired. The purges—which are more reminiscent of the communist past than of a democratic future—are the result of government-sanctioned programs to weed out public employees who may have received their positions due to their Communist affiliation.

  9. Geothermal Progress Monitor report No. 5. Progress report, June 1981

    SciTech Connect

    Not Available

    1981-01-01

    Updated information is presented on activities and progress in the areas of electric power plants, direct heat applications, deep well drilling, leasing of federal lands, legislative and regulatory actions, research and development, and others. Special attention is given in this report to 1980 highlights, particularly in the areas of electric and direct heat uses, drilling, and the Federal lands leasing program. This report also includes a summary of the DOE FY 1982 geothermal budget request to Congress.

  10. Geothermal Progress Monitor report No. 8. Progress report

    SciTech Connect

    Not Available

    1983-11-01

    Geothermal Progress Monitor (GPM) Report Number 8 presents information concerning ongoing technology transfer activities and the mechanisms used to support these activities within geothermal R and D programs. A state-by-state review of major geothermal development activities for the reporting period 1 February 1983 through 31 July 1983 is provided. Recent drilling and exploration efforts and the current status of geothermal electric power plant development in the United States are summarized.

  11. Electron transporting semiconducting polymers in organic electronics.

    PubMed

    Zhao, Xingang; Zhan, Xiaowei

    2011-07-01

    Significant progress has been achieved in the preparation of semiconducting polymers over the past two decades, and successful commercial devices based on them are slowly beginning to enter the market. However, most of the conjugated polymers are hole transporting, or p-type, semiconductors that have seen a dramatic rise in performance over the last decade. Much less attention has been devoted to electron transporting, or n-type, materials that have lagged behind their p-type counterparts. Organic electron transporting materials are essential for the fabrication of organic p-n junctions, organic photovoltaic cells (OPVs), n-channel organic field-effect transistors (OFETs), organic light-emitting diodes (OLEDs) and complementary logic circuits. In this critical review we focus upon recent developments in several classes of electron transporting semiconducting polymers used in OLEDs, OFETs and OPVs, and survey and analyze what is currently known concerning electron transporting semiconductor architecture, electronic structure, and device performance relationships (87 references).

  12. Hanford Site Pollution Prevention Plan Progress report, 1993

    SciTech Connect

    Not Available

    1994-08-01

    This report tracks progress against the goals stated in the Hanford Site 5-year Pollution Prevention Plan. The executive summary of the plan was submitted to the Washington State Department of Ecology (Ecology) in September 1992. The plan, executive summary, and the progress reports are elements of a pollution prevention planning program that is required by Washington Administrative Code (WAC) 173-307 for all hazardous substance users and/or all hazardous waste generators regulated by Ecology. These regulations implement Chapter 70.95C, Revised Code of Washington, an act relating to hazardous waste reduction. The act encourages voluntary efforts to redesign industrial processes to help reduce or eliminate hazardous substances and hazardous waste byproducts, and to maximize the inprocess reuse or reclamation of valuable spent material. Although the Hanford Site is exempt, it is voluntarily complying with this state regulatory-mandated program. This is the first year the Hanford Site is submitting a progress report. It covers calendar year 1993 plus the last quarter of 1992. What is reported, in accordance with WAC 173-307, are reductions in hazardous substance use and hazardous waste generated. A system of Process Waste Assessments (PWA) was chosen to meet the requirements of the program. The PWAs were organized by a physical facility or company organization. Each waste-generating facility/organization performed PWAs to identify, screen, and analyze their own reduction options. Each completed PWA identified any number of reduction opportunities, that are listed individually in the plan and summarized by category in the executive summary. These opportunities were to be implemented or evaluated further over the duration of the 5-year plan. The basis of this progress report is to track action taken on these PWA reduction opportunities in relationship to achieving the goals stated in the Pollution Prevention Plan.

  13. Regulatory pathways coordinating cell cycle progression in early Xenopus development.

    PubMed

    Gotoh, Tetsuya; Villa, Linda M; Capelluto, Daniel G S; Finkielstein, Carla V

    2011-01-01

    The African clawed frog, Xenopus laevis, is used extensively as a model organism for studying both cell development and cell cycle regulation. For over 20 years now, this model organism has contributed to answering fundamental questions concerning the mechanisms that underlie cell cycle transitions--the cellular components that synthesize, modify, repair, and degrade nucleic acids and proteins, the signaling pathways that allow cells to communicate, and the regulatory pathways that lead to selective expression of subsets of genes. In addition, the remarkable simplicity of the Xenopus early cell cycle allows for tractable manipulation and dissection of the basic components driving each transition. In this organism, early cell divisions are characterized by rapid cycles alternating phases of DNA synthesis and division. The post-blastula stages incorporate gap phases, lengthening progression, and allowing more time for DNA repair. Various cyclin/Cdk complexes are differentially expressed during the early cycles with orderly progression being driven by both the combined action of cyclin synthesis and degradation and the appropriate selection of specific substrates by their Cdk components. Like other multicellular organisms, chief developmental events in early Xenopus embryogenesis coincide with profound remodeling of the cell cycle, suggesting that cell proliferation and differentiation events are linked and coordinated through crosstalk mechanisms acting on signaling pathways involving the expression of cell cycle control genes.

  14. Progress on alternative energy resources

    NASA Astrophysics Data System (ADS)

    Couch, H. T.

    1982-03-01

    Progress in the year 1981 toward the development of energy systems suitable for replacing petroleum products combustion and growing in use to fulfill a near term expansion in energy use is reviewed. Coal is noted to be a potentially heavy pollution source, and the presence of environmentally acceptable methods of use such as fluidized-bed combustion and gasification and liquefaction reached the prototype stage in 1981, MHD power generation was achieved in two U.S. plants, with severe corrosion problems remaining unsolved for the electrodes. Solar flat plate collectors sales amounted to 20 million sq ft in 1981, and solar thermal electric conversion systems with central receivers neared completion. Solar cells are progressing toward DOE goals of $.70/peak W by 1986, while wind energy conversion sales were 2000 machines in 1981, and the industry is regarded as maturing. Finally, geothermal, OTEC, and fusion systems are reviewed.

  15. Progress of MICE RFCC Module

    SciTech Connect

    Li, D.; Bowring, D.; DeMello, A.; Gourlay, S.; Green, M.; Li, N.; Niinikoski, T.; Pan, H.; Prestemon, S.; Virostek, S.; Zisman, M.; Bross, A.; Carcagno, R.; Kashikhin, V.; Sylvester, C.; Chen, A. B.; Guo, Bin; Li, Liyi; Xu, Fengyu; Cao, Y.; Sun, S.; Wang, Li; Yin, Lixin; Luo, Tianhuan; Summers, Don; Smith, B.; Radovinsky, A.; Zhukovsky, A.; Kaplan, D.

    2012-05-20

    Recent progress on the design and fabrication of the RFCC (RF and superconducting Coupling Coil) module for the international MICE (Muon Ionization Cooling Experiment) are reported. The MICE ionization cooling channel has two RFCC modules, each having four 201- MHz normal conducting RF cavities surrounded by one superconducting coupling coil (solenoid) magnet. The magnet is designed to be cooled by three cryocoolers. Fabrication of the RF cavities is complete; preparation for the cavity electro-polishing, low power RF measurements, and tuning are in progress at Lawrence Berkeley National Laboratory (LBNL). Fabrication of the cold mass of the first coupling coil magnet has been completed in China and the cold mass arrived at LBNL in late 2011. Preparations for testing the cold mass are currently under way at Fermilab. Plans for the RFCC module assembly and integration are being developed and are described.

  16. Recent Progress in Terahertz Metasurfaces

    NASA Astrophysics Data System (ADS)

    Al-Naib, Ibraheem; Withayachumnankul, Withawat

    2017-03-01

    In the past decade, the concept of metasurfaces has gradually dominated the field of metamaterials owing to their fascinating optical properties and simple planar geometries. At terahertz frequencies, the concept has been driven further by the availability of advanced micro-fabrication technologies that deliver sub-micron accuracy, well below the terahertz wavelengths. Furthermore, terahertz spectrometers with high dynamic range and amplitude and phase sensitivity provide valuable information for the study of metasurfaces in general. In this paper, we review recent progress in terahertz metasurfaces mainly in the last 5 years. The first part covers nonuniform metasurfaces that perform beamforming in reflection and transmission. In addition, we briefly overview four different methodologies that can be utilized in realizing high-quality-factor metasurfaces. We also describe two recent approaches to tuning the frequency response of terahertz metasurfaces using graphene as an active medium. Finally, we provide a brief summary and outlook for future developments in this rapidly progressing field.

  17. Damage Progression in Bolted Composites

    NASA Technical Reports Server (NTRS)

    Minnetyan, Levon; Chamis, Christos; Gotsis, Pascal K.

    1998-01-01

    Structural durability,damage tolerance,and progressive fracture characteristics of bolted graphite/epoxy composite laminates are evaluated via computational simulation. Constituent material properties and stress and strain limits are scaled up to the structure level to evaluate the overall damage and fracture propagation for bolted composites. Single and double bolted composite specimens with various widths and bolt spacings are evaluated. The effect of bolt spacing is investigated with regard to the structural durability of a bolted joint. Damage initiation, growth, accumulation, and propagation to fracture are included in the simulations. Results show the damage progression sequence and structural fracture resistance during different degradation stages. A procedure is outlined for the use of computational simulation data in the assessment of damage tolerance, determination of sensitive parameters affecting fracture, and interpretation of experimental results with insight for design decisions.

  18. Damage Progression in Bolted Composites

    NASA Technical Reports Server (NTRS)

    Minnetyan, Levon; Chamis, Christos C.; Gotsis, Pascal K.

    1998-01-01

    Structural durability, damage tolerance, and progressive fracture characteristics of bolted graphite/epoxy composite laminates are evaluated via computational simulation. Constituent material properties and stress and strain limits are scaled up to the structure level to evaluate the overall damage and fracture propagation for bolted composites. Single and double bolted composite specimens with various widths and bolt spacings are evaluated. The effect of bolt spacing is investigated with regard to the structural durability of a bolted joint. Damage initiation, growth, accumulation, and propagation to fracture are included in the simulations. Results show the damage progression sequence and structural fracture resistance during different degradation stages. A procedure is outlined for the use of computational simulation data in the assessment of damage tolerance, determination of sensitive parameters affecting fracture, and interpretation of experimental results with insight for design decisions.

  19. Progress Toward National Aeronautics Goals

    NASA Technical Reports Server (NTRS)

    Russo, Carlo J.; Sehra, Arun K.

    1999-01-01

    NASA has made definitive progress towards achieving several bold U.S. goals in aeronautics related to air breathing engines. The advanced technologies developed towards these goals span applications from general aviation to large subsonic and supersonic aircraft. The proof of successful technology development is demonstrated through successful technology transfer to U.S. industry and projected fleet impact. Specific examples of progress are discussed that quantifies the achievement towards these goals. In addition, a more detailed vision for NASA aeronautics is defined and key strategic issues are explored which invite international and national debate and involvement especially in reduced environmental impact for subsonic and supersonic aircraft, dramatic new capabilities in general aviation engines, and reduced development cycle time and costs.

  20. Progress in Heavy Ion Fusion

    SciTech Connect

    Herrmannsfeldt, W.B.

    1988-09-01

    The progress of the field of Heavy Ion Fusion has been documented in the proceedings of the series of International Symposia that, in recent years, have occurred every second year. The latest of these conferences was hosted by Gesellshaft fuer Schwerionenforshung (GSI) in Darmstadt, West Germany, June 28-30, 1988. For this report, a few highlights from the conference are selected, stressing experimental progress and prospects for future advances. A little extra time is devoted to report on the developments at the Lawrence Berkeley Laboratory (LBL) which is the center for most of the HIFAR program. The Director of the HIFAR program at LBL is Denis Keefe, who presented the HIF report at the last two of the meetings in this series, and in whose place the author is appearing now. 4 refs., 1 fig.

  1. Cultural Neuroscience: Progress and Promise

    PubMed Central

    Chiao, Joan Y.; Cheon, Bobby K.; Pornpattanangkul, Narun; Mrazek, Alissa J.; Blizinsky, Katherine D.

    2013-01-01

    The nature and origin of human diversity has been a source of intellectual curiosity since the beginning of human history. Contemporary advances in cultural and biological sciences provide unique opportunities for the emerging field of cultural neuroscience. Research in cultural neuroscience examines how cultural and genetic diversity shape the human mind, brain and behavior across multiple time scales: situation, ontogeny and phylogeny. Recent progress in cultural neuroscience provides novel theoretical frameworks for understanding the complex interaction of environmental, cultural and genetic factors in the production of adaptive human behavior. Here, we provide a brief history of cultural neuroscience, theoretical and methodological advances, as well as empirical evidence of the promise of and progress in the field. Implications of this research for population health disparities and public policy are discussed. PMID:23914126

  2. Some Thoughts on "Using Learning Progressions to Design Vertical Scales That Support Coherent Inferences about Student Growth"

    ERIC Educational Resources Information Center

    Kingston, Neal M.; Broaddus, Angela; Lao, Hongling

    2015-01-01

    Briggs and Peck (2015) have written a thought-provoking article on the use of learning progressions in the design of vertical scales that support inferences about student growth. Organized learning models, including learning trajectories, learning progressions, and learning maps have been the subject of research for many years, but more recently…

  3. Gammasphere software development. Progress report

    SciTech Connect

    Piercey, R.B.

    1994-01-01

    This report describes the activities of the nuclear physics group at Mississippi State University which were performed during 1993. Significant progress has been made in the focus areas: chairing the Gammasphere Software Working Group (SWG); assisting with the porting and enhancement of the ORNL UPAK histogramming software package; and developing standard formats for Gammasphere data products. In addition, they have established a new public ftp archive to distribute software and software development tools and information.

  4. Recent progress of quantum annealing

    SciTech Connect

    Suzuki, Sei

    2015-03-10

    We review the recent progress of quantum annealing. Quantum annealing was proposed as a method to solve generic optimization problems. Recently a Canadian company has drawn a great deal of attention, as it has commercialized a quantum computer based on quantum annealing. Although the performance of quantum annealing is not sufficiently understood, it is likely that quantum annealing will be a practical method both on a conventional computer and on a quantum computer.

  5. Revolution and progress in medicine.

    PubMed

    Goodwin, William

    2015-02-01

    This paper adapts Kuhn's conceptual framework to developmental episodes in the theory and practice of medicine. Previous attempts to understand the reception of Ignaz Semmelweis's work on puerperal fever in Kuhnian terms are used as a starting point. The author identifies some limitations of these attempts and proposes a new way of understanding the core Kuhnian notions of "paradigm," "progress," and "revolution" in the context of a socially embedded technoscience such as medicine.

  6. Ongoing Progress in Spacecraft Controls

    NASA Technical Reports Server (NTRS)

    Ghosh, Dave (Editor)

    1992-01-01

    This publication is a collection of papers presented at the Mars Mission Research Center workshop on Ongoing Progress in Spacecraft Controls. The technical program addressed additional Mars mission control problems that currently exist in robotic missions in addition to human missions. Topics include control systems design in the presence of large time delays, fuel-optimal propulsive control, and adaptive control to handle a variety of unknown conditions.

  7. PROGRESS IN ACUTE MYELOID LEUKEMIA

    PubMed Central

    Kadia, Tapan M.; Ravandi, Farhad; O’Brien, Susan; Cortes, Jorge; Kantarjian, Hagop M.

    2014-01-01

    Significant progress has been made in the treatment of acute myeloid leukemia (AML). Steady gains in clinical research and a renaissance of genomics in leukemia have led to improved outcomes. The recognition of tremendous heterogeneity in AML has allowed individualized treatments of specific disease entities within the context of patient age, cytogenetics, and mutational analysis. The following is a comprehensive review of the current state of AML therapy and a roadmap of our approach to these distinct disease entities. PMID:25441110

  8. Progress in breast cancer: overview.

    PubMed

    Arteaga, Carlos L

    2013-12-01

    This edition of CCR Focus titled Research in Breast Cancer: Frontiers in Genomics, Biology, and Clinical Investigation reviews six topics that cover areas of translational research of high impact in breast cancer. These topics represent areas of breast cancer research where significant progress has occurred but also where very important challenges remain. The papers in this CCR Focus section are contributed by experts in the respective areas of investigation. Herein, key aspects of these contributions and the research directions they propose are reviewed.

  9. Progress in NTHMP Hazard Assessment

    USGS Publications Warehouse

    Gonzalez, F.I.; Titov, V.V.; Mofjeld, H.O.; Venturato, A.J.; Simmons, R.S.; Hansen, R.; Combellick, R.; Eisner, R.K.; Hoirup, D.F.; Yanagi, B.S.; Yong, S.; Darienzo, M.; Priest, G.R.; Crawford, G.L.; Walsh, T.J.

    2005-01-01

    The Hazard Assessment component of the U.S. National Tsunami Hazard Mitigation Program has completed 22 modeling efforts covering 113 coastal communities with an estimated population of 1.2 million residents that are at risk. Twenty-three evacuation maps have also been completed. Important improvements in organizational structure have been made with the addition of two State geotechnical agency representatives to Steering Group membership, and progress has been made on other improvements suggested by program reviewers. ?? Springer 2005.

  10. Visual Analytics Technology Transition Progress

    SciTech Connect

    Scholtz, Jean; Cook, Kristin A.; Whiting, Mark A.; Lemon, Douglas K.; Greenblatt, Howard

    2009-09-23

    The authors provide a description of the transition process for visual analytic tools and contrast this with the transition process for more traditional software tools. This paper takes this into account and describes a user-oriented approach to technology transition including a discussion of key factors that should be considered and adapted to each situation. The progress made in transitioning visual analytic tools in the past five years is described and the challenges that remain are enumerated.

  11. Virtual Worlds for Virtual Organizing

    NASA Astrophysics Data System (ADS)

    Rhoten, Diana; Lutters, Wayne

    The members and resources of a virtual organization are dispersed across time and space, yet they function as a coherent entity through the use of technologies, networks, and alliances. As virtual organizations proliferate and become increasingly important in society, many may exploit the technical architecture s of virtual worlds, which are the confluence of computer-mediated communication, telepresence, and virtual reality originally created for gaming. A brief socio-technical history describes their early origins and the waves of progress followed by stasis that brought us to the current period of renewed enthusiasm. Examination of contemporary examples demonstrates how three genres of virtual worlds have enabled new arenas for virtual organizing: developer-defined closed worlds, user-modifiable quasi-open worlds, and user-generated open worlds. Among expected future trends are an increase in collaboration born virtually rather than imported from existing organizations, a tension between high-fidelity recreations of the physical world and hyper-stylized imaginations of fantasy worlds, and the growth of specialized worlds optimized for particular sectors, companies, or cultures.

  12. Information Loss from Technological Progress

    NASA Astrophysics Data System (ADS)

    Townsend, P. D.

    2014-12-01

    Progress in electronics and optics offers faster computers, and rapid communication via the internet that is matched by ever larger and evolving storage systems. Instinctively one assumes that this must be totally beneficial. However advances in software and storage media are progressing in ways which are frequently incompatible with earlier systems and the economics and commercial pressures rarely guarantee total compatibility with earlier systems. Instead, the industries actively choose to force the users to purchase new systems and software. Thus we are moving forward with new technological variants that may have access to only the most recent systems and we will have lost earlier alternatives. The reality is that increased processing speed and storage capacity are matched by an equally rapid decline in the access and survival lifetime of older information. This pattern is not limited to modern electronic systems but is evident throughout history from writing on stone and clay tablets to papyrus and paper. It is equally evident in image systems from painting, through film, to magnetic tapes and digital cameras. In sound recording we have variously progressed from wax discs to vinyl, magnetic tape and CD formats. In each case the need for better definition and greater capacity has forced the earlier systems into oblivion. Indeed proposed interactive music systems could similarly relegate music CDs to specialist collections. The article will track some of the examples and discuss the consequences as well as noting that this information loss is further compounded by developments in language and changes in cultural views of different societies.

  13. Mathematical models of diabetes progression.

    PubMed

    De Gaetano, Andrea; Hardy, Thomas; Beck, Benoit; Abu-Raddad, Eyas; Palumbo, Pasquale; Bue-Valleskey, Juliana; Pørksen, Niels

    2008-12-01

    Few attempts have been made to model mathematically the progression of type 2 diabetes. A realistic representation of the long-term physiological adaptation to developing insulin resistance is necessary for effectively designing clinical trials and evaluating diabetes prevention or disease modification therapies. Writing a good model for diabetes progression is difficult because the long time span of the disease makes experimental verification of modeling hypotheses extremely awkward. In this context, it is of primary importance that the assumptions underlying the model equations properly reflect established physiology and that the mathematical formulation of the model give rise only to physically plausible behavior of the solutions. In the present work, a model of the pancreatic islet compensation is formulated, its physiological assumptions are presented, some fundamental qualitative characteristics of its solutions are established, the numerical values assigned to its parameters are extensively discussed (also with reference to available cross-sectional epidemiologic data), and its performance over the span of a lifetime is simulated under various conditions, including worsening insulin resistance and primary replication defects. The differences with respect to two previously proposed models of diabetes progression are highlighted, and therefore, the model is proposed as a realistic, robust description of the evolution of the compensation of the glucose-insulin system in healthy and diabetic individuals. Model simulations can be run from the authors' web page.

  14. Progress toward universal health coverage in ASEAN

    PubMed Central

    Van Minh, Hoang; Pocock, Nicola Suyin; Chaiyakunapruk, Nathorn; Chhorvann, Chhea; Duc, Ha Anh; Hanvoravongchai, Piya; Lim, Jeremy; Lucero-Prisno, Don Eliseo; Ng, Nawi; Phaholyothin, Natalie; Phonvisay, Alay; Soe, Kyaw Min; Sychareun, Vanphanom

    2014-01-01

    Background The Association of Southeast Asian Nations (ASEAN) is characterized by much diversity in terms of geography, society, economic development, and health outcomes. The health systems as well as healthcare structure and provisions vary considerably. Consequently, the progress toward Universal Health Coverage (UHC) in these countries also varies. This paper aims to describe the progress toward UHC in the ASEAN countries and discuss how regional integration could influence UHC. Design Data reported in this paper were obtained from published literature, reports, and gray literature available in the ASEAN countries. We used both online and manual search methods to gather the information and ‘snowball’ further data. Results We found that, in general, ASEAN countries have made good progress toward UHC, partly due to relatively sustained political commitments to endorse UHC in these countries. However, all the countries in ASEAN are facing several common barriers to achieving UHC, namely 1) financial constraints, including low levels of overall and government spending on health; 2) supply side constraints, including inadequate numbers and densities of health workers; and 3) the ongoing epidemiological transition at different stages characterized by increasing burdens of non-communicable diseases, persisting infectious diseases, and reemergence of potentially pandemic infectious diseases. The ASEAN Economic Community's (AEC) goal of regional economic integration and a single market by 2015 presents both opportunities and challenges for UHC. Healthcare services have become more available but health and healthcare inequities will likely worsen as better-off citizens of member states might receive more benefits from the liberalization of trade policy in health, either via regional outmigration of health workers or intra-country health worker movement toward private hospitals, which tend to be located in urban areas. For ASEAN countries, UHC should be explicitly

  15. Fully biodegradable coronary stents : progress to date.

    PubMed

    Ramcharitar, Steve; Serruys, Patrick W

    2008-01-01

    The limitations of currently available metallic drug-eluting stents have renewed interest in biodegradable stents (BDS). Apart from removing the (offending) foreign material that may potentiate a thrombotic event, BDS have the advantage of avoiding 'full metal jackets,' and thus can preclude subsequent coronary surgery. In addition, they do not interfere with the diagnostic evaluation of non-invasive imaging such as cardiac magnetic resonance and CT. There are now several BDS in development or in clinical trials that incorporate a variety of biodegradable polymer technologies. Two broad categories of materials are generally used: those made from organic biopolymers and those made from corrodible metals. However, to date, none of the materials/stents tested have been able to establish a perfect balance between biocompatibility, the kinetics of degradation needed to maintain mechanical strength to limit recoil, and inflammation. However, studies, such as the ABSORB trial with the everolimus eluting poly-L-lactide stent, which demonstrated comparable restenotic rates with bare metallic stents and a low incidence of major adverse cardiac events (MACE) at 12 months of 3.3%, with only one patient having a non-Q-wave myocardial infarction and no target lesion revascularization, suggest that there has been significant progress with respect to the earlier prototypes. The acute recoil observed could potentially be addressed with the polytyrosine REVA stent currently being evaluated in the RESORB trial, which incorporates a novel locking mechanism within its design. Alternative BDS designs include the combination of an antiproliferative drug with endothelial progenitor cell capturing antibodies to facilitate epithelialization and/or dual eluting having, in addition to the antiproliferative drug, polymeric salicyclic acid to limit inflammation. Compared with biodegradable polymers, there are fewer metals used in the manufacture of BDS. The only metal BDS in trials is the

  16. On the organ trail: insights into organ regeneration in the planarian.

    PubMed

    Roberts-Galbraith, Rachel H; Newmark, Phillip A

    2015-06-01

    Advances in stem cell biology have led to the derivation of diverse cell types, yet challenges remain in creating complex tissues and functional organs. Unlike humans, some animals regenerate all missing tissues and organs successfully after dramatic injuries. Studies of organisms with exceptional regenerative capacity, like planarians, could complement in vitro studies and reveal mechanistic themes underlying regeneration on the scale of whole organs and tissues. In this review, we outline progress in understanding planarian organ regeneration, with focus on recent studies of the nervous, digestive, and excretory systems. We further examine molecular mechanisms underlying establishment of diverse cell fates from the planarian stem cell pool. Finally, we explore conceptual directions for future studies of organ regeneration in planarians.

  17. Organ donors: deceased or alive? Quo vadis?

    PubMed

    Rozental, R

    2006-01-01

    Irrespectively of universal shortage of donor organs there is a tendency of increasing the number of transplantations from living and deceased donors. Each of these two methods has positive and negative features. The main obstacles using living donors are health hazard, necessity to solve certain donor's social and psychological problems, possibility of organ trade and moving. The main problems connected with organ retrieval from deceased donors are possible conflicts with public opinion: difficulties in interpretation of brain death, legislation, obtaining of informed consent from donor's relatives, etc. Future progress in organ transplantation may take place through activation of organ retrieval from deceased donors. The most perspective ways are change to presumed consent in all countries, establishing of centralized system of donor detection and registration, intensification of transplant coordination, active contacts with mass-media, etc. It is necessary to increase (enhance) participation of the members of the public in organ donation process, to develop solidarity among the public members and to involve public authorities to deal with this problem. Bioethical standards should be put in accordance with common progress and some ethical traditions should be changed.

  18. Harvesting organs for paediatric transplantation: medical features.

    PubMed

    Nivet, H

    1989-01-01

    The progress in organ transplantation has led to a rise in the demand for organs. Paediatric intensive care units are the main source for obtaining organs. Every "brain dead" patient should be regarded as a potential donor. General contraindications to organ donation are: systemic viral or bacterial infections and extra-cerebral malignancy. They are also organ-specific contraindications. The criteria for the diagnosis of "brain death" have been widely studied and defined. Care of brain dead donors consists of maintenance of cardiac, pulmonary and renal function. Monitoring requires control of central venous and arterial blood pressure, core temperature, urine flow, heart rate and biological data on both urine and blood. A 5% dextrose infusion is maintained with added potassium and sodium chloride according to the urine flow, detectable water loss, and blood and urine composition. Hypotension due to hypovolaemia requires immediate treatment with blood, colloid or albumin infusion. Persistent hypotension with cardiac pump failure is treated with inotropic agents: dopamine and/or dobutamine. Raised urine flow due to diabetes insipidus requires desmopressin (dDAVP). Progress in organ collection requires the consent of the parents and highly motivated medical teams.

  19. Lead-Lead and Rubidium-Strontium In Situ Dating Using the Chemistry, Organics, and Dating EXperiment (CODEX)

    NASA Astrophysics Data System (ADS)

    Anderson, F. S.; Whitaker, T. J.; Levine, J.; Beck, S.

    2016-10-01

    We describe new results for Pb-Pb dating, and progress on laser development, for the Pb-Pb and Rb-Sr measuring, organics detecting, and elemental abundance mapping Chemistry, Organics, and Dating EXperiment (CODEX) instrument.

  20. Identification and Targeting of Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis

    DTIC Science & Technology

    2012-10-01

    Tyrosine Kinase Activity in Prostate Cancer Initiation, Progression, and Metastasis PRINCIPAL INVESTIGATOR: Justin Drake CONTRACTING...PROJECT NUMBER Justin Drake and Owen Witte 5e. TASK NUMBER Email: jdrake@mednet.ucla.edu 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S...of tyrosine kinase networks during prostate cancer progression Justin M. Drakea, Nicholas A. Grahamb,c, Tanya Stoyanovaa, Amir Sedghia, Andrew S