THE NEW ONLINE METADATA EDITOR FOR GENERATING STRUCTURED METADATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Devarakonda, Ranjeet; Shrestha, Biva; Palanisamy, Giri

Nobody is better suited to describe data than the scientist who created it. This description about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset [1]. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, andmore » locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [2][4]. OME is part of ORNL s Mercury software fleet [2][3]. It was jointly developed to support projects funded by the United States Geological Survey (USGS), U.S. Department of Energy (DOE), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). OME s architecture provides a customizable interface to support project-specific requirements. Using this new architecture, the ORNL team developed OME instances for USGS s Core Science Analytics, Synthesis, and Libraries (CSAS&L), DOE s Next Generation Ecosystem Experiments (NGEE) and Atmospheric Radiation Measurement (ARM) Program, and the international Surface Ocean Carbon Dioxide ATlas (SOCAT). Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. From the information on the form, the Metadata Editor can create an XML file on the server that the editor is installed or to the user s personal computer. Researchers can also use the ORNL Metadata Editor to modify existing XML metadata files. As an example, an NGEE Arctic scientist use OME to register their datasets to the NGEE data archive and allows the NGEE archive to publish these datasets via a data search portal (http://ngee.ornl.gov/data). These highly descriptive metadata created using OME allows the Archive to enable advanced data search options using keyword, geo-spatial, temporal and ontology filters. Similarly, ARM OME allows scientists or principal investigators (PIs) to submit their data products to the ARM data archive. How would OME help Big Data Centers like the Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC)? The ORNL DAAC is one of NASA s Earth Observing System Data and Information System (EOSDIS) data centers managed by the Earth Science Data and Information System (ESDIS) Project. The ORNL DAAC archives data produced by NASA's Terrestrial Ecology Program. The DAAC provides data and information relevant to biogeochemical dynamics, ecological data, and environmental processes, critical for understanding the dynamics relating to the biological, geological, and chemical components of the Earth's environment. Typically data produced, archived and analyzed is at a scale of multiple petabytes, which makes the discoverability of the data very challenging. Without proper metadata associated with the data, it is difficult to find the data you are looking for and equally difficult to use and understand the data. OME will allow data centers like the NGEE and ORNL DAAC to produce meaningful, high quality, standards-based, descriptive information about their data products in-turn helping with the data discoverability and interoperability. Useful Links: USGS OME: http://mercury.ornl.gov/OME/ NGEE OME: http://ngee-arctic.ornl.gov/ngeemetadata/ ARM OME: http://archive2.ornl.gov/armome/ Contact: Ranjeet Devarakonda (devarakondar@ornl.gov) References: [1] Federal Geographic Data Committee. Content standard for digital geospatial metadata. Federal Geographic Data Committee, 1998. [2] Devarakonda, Ranjeet, et al. "Mercury: reusable metadata management, data discovery and access system." Earth Science Informatics 3.1-2 (2010): 87-94. [3] Wilson, B. E., Palanisamy, G., Devarakonda, R., Rhyne, B. T., Lindsley, C., & Green, J. (2010). Mercury Toolset for Spatiotemporal Metadata. [4] Pouchard, L. C., Branstetter, M. L., Cook, R. B., Devarakonda, R., Green, J., Palanisamy, G., ... & Noy, N. F. (2013). A Linked Science investigation: enhancing climate change data discovery with semantic technologies. Earth science informatics, 6(3), 175-185.« less

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Specification DOT-107A * * * * seamless steel tank...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

In vivo cation exchange in quantum dots for tumor-specific imaging.

PubMed

Liu, Xiangyou; Braun, Gary B; Qin, Mingde; Ruoslahti, Erkki; Sugahara, Kazuki N

2017-08-24

In vivo tumor imaging with nanoprobes suffers from poor tumor specificity. Here, we introduce a nanosystem, which allows selective background quenching to gain exceptionally tumor-specific signals. The system uses near-infrared quantum dots and a membrane-impermeable etchant, which serves as a cation donor. The etchant rapidly quenches the quantum dots through cation exchange (ionic etching), and facilitates renal clearance of metal ions released from the quantum dots. The quantum dots are intravenously delivered into orthotopic breast and pancreas tumors in mice by using the tumor-penetrating iRGD peptide. Subsequent etching quenches excess quantum dots, leaving a highly tumor-specific signal provided by the intact quantum dots remaining in the extravascular tumor cells and fibroblasts. No toxicity is noted. The system also facilitates the detection of peritoneal tumors with high specificity upon intraperitoneal tumor targeting and selective etching of excess untargeted quantum dots. In vivo cation exchange may be a promising strategy to enhance specificity of tumor imaging.The imaging of tumors in vivo using nanoprobes has been challenging due to the lack of sufficient tumor specificity. Here, the authors develop a tumor-specific quantum dot system that permits in vivo cation exchange to achieve selective background quenching and high tumor-specific imaging.

49 CFR 178.348 - Specification DOT 412; cargo tank motor vehicle.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Specification DOT 412; cargo tank motor vehicle...) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.348 Specification DOT 412; cargo tank motor vehicle. ...

49 CFR 178.346 - Specification DOT 406; cargo tank motor vehicle.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 406; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.346 Specification DOT 406; cargo tank motor vehicle. ...

49 CFR 178.347 - Specification DOT 407; cargo tank motor vehicle.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 407; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.347 Specification DOT 407; cargo tank motor vehicle. ...

49 CFR 178.348 - Specification DOT 412; cargo tank motor vehicle.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Specification DOT 412; cargo tank motor vehicle... SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.348 Specification DOT 412; cargo tank motor vehicle. ...

49 CFR 178.346 - Specification DOT 406; cargo tank motor vehicle.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Specification DOT 406; cargo tank motor vehicle...) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.346 Specification DOT 406; cargo tank motor vehicle. ...

49 CFR 178.347 - Specification DOT 407; cargo tank motor vehicle.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Specification DOT 407; cargo tank motor vehicle...) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation § 178.347 Specification DOT 407; cargo tank motor vehicle. ...

ORNL Evaluation of Electrabel Safety Cases for Doel 3 / Tihange 2: Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bass, Bennett Richard; Dickson, Terry L.; Gorti, Sarma B.

Oak Ridge National Laboratory (ORNL) performed a detailed technical review of the 2015 Electrabel (EBL) Safety Cases prepared for the Belgium reactor pressure vessels (RPVs) at Doel 3 and Tihange 2 (D3/T2). The Federal Agency for Nuclear Control (FANC) in Belgium commissioned ORNL to provide a thorough assessment of the existing safety margins against cracking of the RPVs due to the presence of almost laminar flaws found in each RPV. Initial efforts focused on surveying relevant literature that provided necessary background knowledge on the issues related to the quasilaminar flaws observed in D3/T2 reactors. Next, ORNL proceeded to develop anmore » independent quantitative assessment of the entire flaw population in the two Belgian reactors according to the American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code, Section XI, Appendix G, Fracture Toughness Criteria for Protection Against Failure, New York (1992 and 2004). That screening assessment of all EBL-characterized flaws in D3/T2 used ORNL tools, methodologies, and the ASME Code Case N-848, Alternative Characterization Rules for QuasiLaminar Flaws . Results and conclusions from the ORNL flaw acceptance assessments of D3/T2 were compared with those from the 2015 EBL Safety Cases. Specific findings of the ORNL evaluation of that part of the EBL structural integrity assessment focusing on stability of the flaw population subjected to primary design transients include the following: ORNL s analysis results were similar to those of EBL in that very few characterized flaws were found not compliant with the ASME (1992) acceptance criterion. ORNL s application of the more recent ASME Section XI (2004) produced only four noncompliant flaws, all due to LOCAs. The finding of a greater number of non-compliant flaws in the EBL screening assessment is due principally to a significantly more restrictive (conservative) criterion for flaw size acceptance used by EBL. ORNL s screening assessment results (obtained using an analysis methodology different from that of EBL) are interpreted herein as confirming the EBL screening results for D3/T2. ORNL s independent refined analysis demonstrated the EBL-characterized flaw 1660, which is non-compliant in the ORNL and EBL screening assessment, is rendered compliant when modeled as a more realistic individual quasi-laminar flaw using a 3-D XFEM analysis approach. ORNL s and EBL s refined analyses are in good agreement for the flaw 1660 close to the clad/base metal interface; ORNL is not persuaded that repeating this exercise for more than one non-compliant flaw is necessary to accept the EBL conclusions derived from the aggregate of EBL refined analysis results. ORNL General Conclusions Regarding the Structural Integrity Assessment (SIA) Conducted by EBL for D3/T2 Based on comparative evaluations of ORNL and EBL SIA analyses and on consideration of other results, ORNL is in agreement with the general conclusions reported by Electrabel in their RPV D3/T2 Technical Summary Note of April 14, 2015: More than 99 percent of flaws in D3/T2 meet the defined screening criterion, rendering them benign with respect to initiation in the event of a design transient. Refined analyses of non-compliant flaws from the screening assessment indicate that only 11 of the 16196 detected flaws have a critical reference-temperature material index (designated RTNDT) that implies the possibility of the initiation of cleavage fracture at some future time. For those 11 2 flaws, the calculated margin in RTNDT (a measure of acceptable embrittlement relative to end-ofservice-life conditions) is significant, being greater than 80 C. Fatigue crack growth is not a concern in the flaw-acceptability analyses. Primary stress re-evaluation confirms that the collapse pressure is more than 1.5 times the design pressure in the presence of defects detected in D3/T2. Sufficient conservatisms are built into the input data and into the different steps of the SIA; in some cases, those conservatisms are quantified and imply that additional margins exist in the SIA. Taken as a whole, the foregoing results and conclusions confirm the structural integrity of Doel 3 and Tihange 2 under all design transients with ample margin in the presence of the 16196 detected flaws.« less

Characterization of the MVST waste tanks located at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, J.M.; Giaquinto, J.M.; Meeks, A.M.

During the fall of 1996 there was a major effort to sample and analyze the Active Liquid Low-Level Waste (LLLW) tanks at ORNL which include the Melton Valley Storage Tanks (MVST) and the Bethel Valley Evaporator Service Tanks (BVEST). The characterization data summarized in this report was needed to address waste processing options, address concerns of the performance assessment (PA) data for the Waste Isolation Pilot Plant (WIPP), evaluate the characteristics with respect to the waste acceptance criteria (WAC) for WIPP and Nevada Test Site (NTS), address criticality concerns, and meet DOT requirements for transporting the waste. This report onlymore » discusses the analytical characterization data for the MVST waste tanks. The isotopic data presented in this report support the position that fissile isotopes of uranium and plutonium were ``denatured`` as required by administrative controls. In general, MVST sludge was found to be both hazardous by RCRA characteristics and the transuranic alpha activity was well about the limit for TRU waste. The characteristics of the MVST sludge relative to the WIPP WAC limits for fissile gram equivalent, plutonium equivalent activity, and thermal power from decay heat, were estimated from the data in this report and found to be far below the upper boundary for any of the remote-handled transuranic waste requirements for disposal of the waste in WIPP.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoreen, Terrence P

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries for all ORNL LDRD research activities supported during FY 2007. The associated FY 2007 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data andmore » an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching mission to advance the national, economic, and energy security of the United States and promote scientific and technological innovation in support of that mission. As a national resource, the Laboratory also applies its capabilities and skills to specific needs of other federal agencies and customers through the DOE Work for Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at http://www.ornl.gov/. LDRD is a relatively small but vital DOE program that allows ORNL, as well as other DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating exploration of forefront science and technology; (4) serving as a proving ground for new research; and (5) supporting high-risk, potentially high-value R&D. Through LDRD the Laboratory is able to improve its distinctive capabilities and enhance its ability to conduct cutting-edge R&D for its DOE and WFO sponsors. To meet the LDRD objectives and fulfill the particular needs of the Laboratory, ORNL has established a program with two components: the Director's R&D Fund and the Seed Money Fund. As outlined in Table 1, these two funds are complementary. The Director's R&D Fund develops new capabilities in support of the Laboratory initiatives, while the Seed Money Fund is open to all innovative ideas that have the potential for enhancing the Laboratory's core scientific and technical competencies. Provision for multiple routes of access to ORNL LDRD funds maximizes the likelihood that novel ideas with scientific and technological merit will be recognized and supported.« less

The ORNL Indoor Air Quality Study: Re-cap, Context, and Assessment on Radon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tonn, Bruce Edward; Rose, Erin M.; Ternes, Mark P.

As part of the retrospective evaluation of the U.S. Department of Energy s low-income Weatherization Assistance Program that was led by Oak Ridge National Laboratory (ORNL), an assessment of the impacts of weatherization on indoor air quality (IAQ) was conducted. This assessment included nearly 500 treatment and control homes across the country. Homes were monitored for carbon monoxide, radon, formaldehyde, temperature and humidity pre- and post-weatherization. This report focuses on the topic of radon and addresses issues not thoroughly discussed in the original IAQ report. The size, scope and rigor of the radon component of the IAQ study are comparedmore » to previous studies that assessed the impacts of weatherization on indoor radon levels. It is found that the ORNL study is by far the most extensive study conducted to date, though the ORNL results are consistent with the findings of the other studies. However, the study does have limitations related to its reliance on short-term measurements of radon and inability to attribute changes in radon levels in homes post-weatherization to specific weatherization measures individually or in combination.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This Remedial Investigation (RI) Work Plan has been developed as part of the US Department of Energy`s (DOE`s) investigation of the Groundwater Operable Unit (GWOU) at Oak Ridge National Laboratory (ORNL) located near Oak Ridge, Tennessee. The first iteration of the GWOU RI Work Plan is intended to serve as a strategy document to guide the ORNL GWOU RI. The Work Plan provides a rationale and organization for groundwater data acquisition, monitoring, and remedial actions to be performed during implementation of environmental restoration activities associated with the ORNL GWOU. It Is important to note that the RI Work Plan formore » the ORNL GWOU is not a prototypical work plan. The RI will be conducted using annual work plans to manage the work activities, and task reports will be used to document the results of the investigations. Sampling and analysis results will be compiled and reported annually with a review of data relative to risk (screening level risk assessment review) for groundwater. This Work Plan outlines the overall strategy for the RI and defines tasks which are to be conducted during the initial phase of investigation. This plan is presented with the understanding that more specific addenda to the plan will follow.« less

Management and Analysis of Radiation Portal Monitor Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rowe, Nathan C; Alcala, Scott; Crye, Jason Michael

2014-01-01

Oak Ridge National Laboratory (ORNL) receives, archives, and analyzes data from radiation portal monitors (RPMs). Over time the amount of data submitted for analysis has grown significantly, and in fiscal year 2013, ORNL received 545 gigabytes of data representing more than 230,000 RPM operating days. This data comes from more than 900 RPMs. ORNL extracts this data into a relational database, which is accessed through a custom software solution called the Desktop Analysis and Reporting Tool (DART). DART is used by data analysts to complete a monthly lane-by-lane review of RPM status. Recently ORNL has begun to extend its datamore » analysis based on program-wide data processing in addition to the lane-by-lane review. Program-wide data processing includes the use of classification algorithms designed to identify RPMs with specific known issues and clustering algorithms intended to identify as-yet-unknown issues or new methods and measures for use in future classification algorithms. This paper provides an overview of the architecture used in the management of this data, performance aspects of the system, and additional requirements and methods used in moving toward an increased program-wide analysis paradigm.« less

Research in mobile robotics at ORNL/CESAR (Oak Ridge National Laboratory/Center for Engineering Systems Advanced Research)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, R.C.; Weisbin, C.R.; Pin, F.G.

1989-01-01

This paper reviews ongoing and planned research with mobile autonomous robots at the Oak Ridge National Laboratory (ORNL), Center for Engineering Systems Advanced Research (CESAR). Specifically we report on results obtained with the robot HERMIES-IIB in navigation, intelligent sensing, learning, and on-board parallel computing in support of these functions. We briefly summarize an experiment with HERMIES-IIB that demonstrates the capability of smooth transitions between robot autonomy and tele-operation. This experiment results from collaboration among teams at the Universities of Florida, Michigan, Tennessee, and Texas; and ORNL in a program targeted at robotics for advanced nuclear power stations. We conclude bymore » summarizing ongoing R D with our new mobile robot HERMIES-III which is equipped with a seven degree-of-freedom research manipulator arm. 12 refs., 4 figs.« less

49 CFR 180.212 - Repair of seamless DOT 3-series specification cylinders and seamless UN pressure receptacles.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Repair of seamless DOT 3-series specification..., Maintenance and Use of Cylinders § 180.212 Repair of seamless DOT 3-series specification cylinders and seamless UN pressure receptacles. (a) General requirements for repair of DOT 3-series cylinders and UN...

White Paper on the Use of Team Calendars with the JIRA Issue Tracking System and Confluence Collaboration Tools for the xLPR Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klasky, Hilda B.; Williams, Paul T.; Bass, Bennett Richard

ORNL was tasked by xLPR project management to propose a team calendar for use within the xLPR consortium. Among various options that were considered, the approach judged by ORNL to best fit the needs of the xLPR project is presented in this document. The Atlassian Team Calendars plug-in used with the Confluence collaboration tool was recommended for several reasons, including the advantage that it provides for a tight integration between Confluence (found at https://xlpr.ornl.gov/wiki ) and xLPR s JIRA issue tracking system (found at https://xlpr.ornl.gov/jira ). This document is divided into two parts. The first part (Sections 1-6) consists ofmore » the white paper, which highlights some of the ways that Team Calendars can improve com mun ication between xLPR project managers, group leads, and team members when JIRA is applied for both issue tracking and change-management activities. Specific points emphasized herein are as follows: The Team Calendar application greatly enhances the added value that the JIRA and Confluence tools bring to the xLPR Project. The Team Calendar can improve com mun ication between xLPR project managers, group leads, and team members when JIRA is applied for both issue tracking and change-management activities. The Team Calendar works across different email tools such as Outlook 2011, Outlook 2010, Outlook 2007, Google Calendars and Mac s iCalendar to name a few. xLPR users can now access the wiki Confluence (with embedded Team Calendars) directly from JIRA without having to re-validate their login. The second part consists of an Annex (Section 7), which describes how users can subscribe to Team Calendars from different calendar applications. Specific instructions are given in the Annex that describe how to Import xLPR Team Calendar to Outlook Version Office 2010 Import xLPR Team Calendar to Outlook Version Office 2007 Subscribe to Team Calendar from Google Calendar The reader is directed to Section 4 for instructions on adding events to the Team Calendar or accessing ORNL staff for assistance with such additions. To seek help with your questions and problems regarding the content of this document, please contact Hilda Klasky at klaskyhb@ornl.gov« less

Data rescue of NASA First ISLSCP (International Satellite Land Surface Climatology Project) Field Experiment (FIFE) aerial observations

NASA Astrophysics Data System (ADS)

Santhana Vannan, S. K.; Boyer, A.; Deb, D.; Beaty, T.; Wei, Y.; Wei, Z.

2017-12-01

The Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC) for biogeochemical dynamics is one of the NASA Earth Observing System Data and Information System (EOSDIS) data centers. ORNL DAAC (https://daac.ornl.gov) is responsible for data archival, product development and distribution, and user support for biogeochemical and ecological data and models. In particular, ORNL DAAC has been providing data management support for NASA's terrestrial ecology field campaign programs for the last several decades. Field campaigns combine ground, aircraft, and satellite-based measurements in specific ecosystems over multi-year time periods. The data collected during NASA field campaigns are archived at the ORNL DAAC (https://daac.ornl.gov/get_data/). This paper describes the effort of the ORNL DAAC team for data rescue of a First ISLSCP Field Experiment (FIFE) dataset containing airborne and satellite data observations from the 1980s. The data collected during the FIFE campaign contain high resolution aerial imageries collected over Kansas. The data rescue workflow was prepared to test for successful recovery of the data from a CD-ROM and to ensure that the data are usable and preserved for the future. The imageries contain spectral reflectance data that can be used as a historical benchmark to examine climatological and ecological changes in the Kansas region since the 1980s. Below are the key steps taken to convert the files to modern standards. Decompress the imageries using custom compression software provided with the data. The compression algorithm created for MS-DOS in 1980s had to be set up to run on modern computer systems. Decompressed files were geo-referenced by using metadata information stored in separate compressed header files. Standardized file names were applied (File names and details were described in separate readme documents). Image files were converted to GeoTIFF format with embedded georeferencing information. Leverage Open Geospatial Consortium (OGC) Web services to provide dynamic data transformation and visualization. We will describe the steps in detail and share lessons learned during the AGU session.

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoreen, Terrence P

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2005 and includes final reports for completed projects and shorter progress reports for projects thatmore » were active, but not completed, during this period. The FY 2005 ORNL LDRD Self-Assessment (ORNL/PPA-2006/2) provides financial data about the FY 2005 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating exploration of forefront science and technology; (4) serving as a proving ground for new research; and (5) supporting high-risk, potentially high-value R&D. Through LDRD the Laboratory is able to improve its distinctive capabilities and enhance its ability to conduct cutting-edge R&D for its DOE and WFO sponsors. To meet the LDRD objectives and fulfill the particular needs of the Laboratory, ORNL has established a program with two components: the Director's R&D Fund and the Seed Money Fund. As outlined in Table 1, these two funds are complementary. The Director's R&D Fund develops new capabilities in support of the Laboratory initiatives, while the Seed Money Fund is open to all innovative ideas that have the potential for enhancing the Laboratory's core scientific and technical competencies. Provision for multiple routes of access to ORNL LDRD funds maximizes the likelihood that novel and seminal ideas with scientific and technological merit will be recognized and supported.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoreen, Terrence P

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2A, 'Laboratory Directed Research and Development' (January 8, 2001), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report describes all ORNL LDRD research activities supported during FY 2004 and includes final reports for completed projects and shorter progress reports for projects thatmore » were active, but not completed, during this period. The FY 2004 ORNL LDRD Self-Assessment (ORNL/PPA-2005/2) provides financial data about the FY 2004 projects and an internal evaluation of the program's management process. ORNL is a DOE multiprogram science, technology, and energy laboratory with distinctive capabilities in materials science and engineering, neutron science and technology, energy production and end-use technologies, biological and environmental science, and scientific computing. With these capabilities ORNL conducts basic and applied research and development (R&D) to support DOE's overarching national security mission, which encompasses science, energy resources, environmental quality, and national nuclear security. As a national resource, the Laboratory also applies its capabilities and skills to the specific needs of other federal agencies and customers through the DOE Work For Others (WFO) program. Information about the Laboratory and its programs is available on the Internet at . LDRD is a relatively small but vital DOE program that allows ORNL, as well as other multiprogram DOE laboratories, to select a limited number of R&D projects for the purpose of: (1) maintaining the scientific and technical vitality of the Laboratory; (2) enhancing the Laboratory's ability to address future DOE missions; (3) fostering creativity and stimulating exploration of forefront science and technology; (4) serving as a proving ground for new research; and (5) supporting high-risk, potentially high-value R&D. Through LDRD the Laboratory is able to improve its distinctive capabilities and enhance its ability to conduct cutting-edge R&D for its DOE and WFO sponsors. To meet the LDRD objectives and fulfill the particular needs of the Laboratory, ORNL has established a program with two components: the Director's R&D Fund and the Seed Money Fund. As outlined in Table 1, these two funds are complementary. The Director's R&D Fund develops new capabilities in support of the Laboratory initiatives, while the Seed Money Fund is open to all innovative ideas that have the potential for enhancing the Laboratory's core scientific and technical competencies. Provision for multiple routes of access to ORNL LDRD funds maximizes the likelihood that novel and seminal ideas with scientific and technological merit will be recognized and supported.« less

49 CFR 178.345 - General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT 407 (§ 178.347), and DOT 412 (§ 178.348) cargo tank motor vehicles. 178.345 Section 178.345 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS...

49 CFR 178.345 - General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT 407 (§ 178.347), and DOT 412 (§ 178.348) cargo tank motor vehicles. 178.345 Section 178.345 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS...

49 CFR 178.345 - General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false General design and construction requirements applicable to Specification DOT 406 (§ 178.346), DOT 407 (§ 178.347), and DOT 412 (§ 178.348) cargo tank motor vehicles. 178.345 Section 178.345 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS...

BUGJEFF311.BOLIB (JEFF-3.1.1) and BUGENDF70.BOLIB (ENDF/B-VII.0) - Generation Methodology and Preliminary Testing of two ENEA-Bologna Group Cross Section Libraries for LWR Shielding and Pressure Vessel Dosimetry

NASA Astrophysics Data System (ADS)

Pescarini, Massimo; Sinitsa, Valentin; Orsi, Roberto; Frisoni, Manuela

2016-02-01

Two broad-group coupled neutron/photon working cross section libraries in FIDO-ANISN format, dedicated to LWR shielding and pressure vessel dosimetry applications, were generated following the methodology recommended by the US ANSI/ANS-6.1.2-1999 (R2009) standard. These libraries, named BUGJEFF311.BOLIB and BUGENDF70.BOLIB, are respectively based on JEFF-3.1.1 and ENDF/B-VII.0 nuclear data and adopt the same broad-group energy structure (47 n + 20 γ) of the ORNL BUGLE-96 similar library. They were respectively obtained from the ENEA-Bologna VITJEFF311.BOLIB and VITENDF70.BOLIB libraries in AMPX format for nuclear fission applications through problem-dependent cross section collapsing with the ENEA-Bologna 2007 revision of the ORNL SCAMPI nuclear data processing system. Both previous libraries are based on the Bondarenko self-shielding factor method and have the same AMPX format and fine-group energy structure (199 n + 42 γ) as the ORNL VITAMIN-B6 similar library from which BUGLE-96 was obtained at ORNL. A synthesis of a preliminary validation of the cited BUGLE-type libraries, performed through 3D fixed source transport calculations with the ORNL TORT-3.2 SN code, is included. The calculations were dedicated to the PCA-Replica 12/13 and VENUS-3 engineering neutron shielding benchmark experiments, specifically conceived to test the accuracy of nuclear data and transport codes in LWR shielding and radiation damage analyses.

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation... REGULATIONS SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

NASA Astrophysics Data System (ADS)

Troparevsky, Claudia; Stocks, George Malcolm

2012-12-01

Increasingly, computational physics stands alongside experiment and theory as an integral part of the modern approach to solving the great scientific challenges of the day on all scales - from cosmology and astrophysics, through climate science, to materials physics, and the fundamental structure of matter. Computational physics touches aspects of science and technology with direct relevance to our everyday lives, such as communication technologies and securing a clean and efficient energy future. This volume of Journal of Physics: Conference Series contains the proceedings of the scientific contributions presented at the 23rd Conference on Computational Physics held in Gatlinburg, Tennessee, USA, in November 2011. The annual Conferences on Computational Physics (CCP) are dedicated to presenting an overview of the most recent developments and opportunities in computational physics across a broad range of topical areas and from around the world. The CCP series has been in existence for more than 20 years, serving as a lively forum for computational physicists. The topics covered by this conference were: Materials/Condensed Matter Theory and Nanoscience, Strongly Correlated Systems and Quantum Phase Transitions, Quantum Chemistry and Atomic Physics, Quantum Chromodynamics, Astrophysics, Plasma Physics, Nuclear and High Energy Physics, Complex Systems: Chaos and Statistical Physics, Macroscopic Transport and Mesoscopic Methods, Biological Physics and Soft Materials, Supercomputing and Computational Physics Teaching, Computational Physics and Sustainable Energy. We would like to take this opportunity to thank our sponsors: International Union of Pure and Applied Physics (IUPAP), IUPAP Commission on Computational Physics (C20), American Physical Society Division of Computational Physics (APS-DCOMP), Oak Ridge National Laboratory (ORNL), Center for Defect Physics (CDP), the University of Tennessee (UT)/ORNL Joint Institute for Computational Sciences (JICS) and Cray, Inc. We are grateful to the committees that helped put the conference together, especially the local organizing committee. Particular thanks are also due to a number of ORNL staff who spent long hours with the administrative details. We are pleased to express our thanks to the conference administrator Ann Strange (ORNL/CDP) for her responsive and efficient day-to-day handling of this event, Sherry Samples, Assistant Conference Administrator (ORNL), Angie Beach and the ORNL Conference Office, and Shirley Shugart (ORNL) and Fern Stooksbury (ORNL) who created and maintained the conference website. Editors: G Malcolm Stocks (ORNL) and M Claudia Troparevsky (UT) http://ccp2011.ornl.gov Chair: Dr Malcolm Stocks (ORNL) Vice Chairs: Adriana Moreo (ORNL/UT) James Guberrnatis (LANL) Local Program Committee: Don Batchelor (ORNL) Jack Dongarra (UTK/ORNL) James Hack (ORNL) Robert Harrison (ORNL) Paul Kent (ORNL) Anthony Mezzacappa (ORNL) Adriana Moreo (ORNL) Witold Nazarewicz (UT) Loukas Petridis (ORNL) David Schultz (ORNL) Bill Shelton (ORNL) Claudia Troparevsky (ORNL) Mina Yoon (ORNL) International Advisory Board Members: Joan Adler (Israel Institute of Technology, Israel) Constantia Alexandrou (University of Cyprus, Cyprus) Claudia Ambrosch-Draxl (University of Leoben, Austria) Amanda Barnard (CSIRO, Australia) Peter Borcherds (University of Birmingham, UK) Klaus Cappelle (UFABC, Brazil) Giovanni Ciccotti (Università degli Studi di Roma 'La Sapienza', Italy) Nithaya Chetty (University of Pretoria, South Africa) Charlotte Froese-Fischer (NIST, US) Giulia A. Galli (University of California, Davis, US) Gillian Gehring (University of Sheffield, UK) Guang-Yu Guo (National Taiwan University, Taiwan) Sharon Hammes-Schiffer (Penn State, US) Alex Hansen (Norweigan UST) Duane D. Johnson (University of Illinois at Urbana-Champaign, US) David Landau (University of Georgia, US) Joaquin Marro (University of Granada, Spain) Richard Martin (UIUC, US) Todd Martinez (Stanford University, US) Bill McCurdy (Lawrence Berkeley National Laboratory, US) Ingrid Mertig (Martin Luther University, Germany) Alejandro Muramatsu (Universitat Stuttgart, Germany) Richard Needs (Cavendish Laboratory, UK) Giuseppina Orlandini (University of Trento, Italy) Martin Savage (University of Washington, US) Thomas Schulthess (ETH, Switzerland) Dzidka Szotek (Daresbury Laboratory, UK) Hideaki Takabe (Osaka University, Japan) William M. Tang (Princeton University, US) James Vary (Iowa State, US) Enge Wang (Chinese Academy of Science, China) Jian-Guo Wang (Institute of Applied Physics and Computational Mathematics, China) Jian-Sheng Wang (National University, Singapore) Dan Wei (Tsinghua University, China) Tony Williams (University of Adelaide, Australia) Rudy Zeller (Julich, Germany) Conference Administrator: Ann Strange (ORNL)

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., carbon bisulfide (disulfide), ethyl chloride, ethylene oxide, nickel carbonyl, spirits of nitroglycerin...; DOT-3B400; DOT-4AA480; DOT-4B400; DOT-4BA400; DOT-4BW400; DOT-3E1800; DOT-39; DOT-3AL400. Carbon...; DOT-3T1800; DOT-3HT2000; DOT-39; DOT-3AL1800. Carbon dioxide, refrigerated liquid (see paragraph (e...

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., carbon bisulfide (disulfide), ethyl chloride, ethylene oxide, nickel carbonyl, spirits of nitroglycerin...; DOT-3B400; DOT-4AA480; DOT-4B400; DOT-4BA400; DOT-4BW400; DOT-3E1800; DOT-39; DOT-3AL400. Carbon...; DOT-3T1800; DOT-3HT2000; DOT-39; DOT-3AL1800. Carbon dioxide, refrigerated liquid (see paragraph (e...

Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes.

PubMed

Dindar, Gülcin; Anger, Andreas M; Mehlhorn, Christine; Hake, Sandra B; Janzen, Christian J

2014-11-12

DOT1 enzymes are conserved methyltransferases that catalyse the methylation of lysine 79 on histone H3 (H3K79). Most eukaryotes contain one DOT1 enzyme, whereas African trypanosomes have two homologues, DOT1A and DOT1B, with different enzymatic activities. DOT1A mediates mono- and dimethylation of H3K76, the homologue of H3K79 in other organisms, whereas DOT1B additionally catalyses H3K76 trimethylation. However, it is unclear how these different enzymatic activities are achieved. Here we employ a trypanosomal nucleosome reconstitution system and structure-guided homology modelling to identify critical residues within and outside the catalytic centre that modulate product specificity. Exchange of these residues transfers the product specificity from one enzyme to the other, and reveals the existence of distinct regulatory domains adjacent to the catalytic centre. Our study provides the first evidence that a few crucial residues in DOT1 enzymes are sufficient to catalyse methyl-state-specific reactions. These results might also have far-reaching consequences for the functional understanding of homologous enzymes in higher eukaryotes.

Design of Mixed Batch Reactor and Column Studies at Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wu, Weimin; Criddle, Craig S.

2015-11-16

We (the Stanford research team) were invited as external collaborators to contribute expertise in environmental engineering and field research at the ORNL IFRC, Oak Ridge, TN, for projects carried out at the Argonne National Laboratory and funded by US DOE. Specifically, we assisted in the design of batch and column reactors using ORNL IFRC materials to ensure the experiments were relevant to field conditions. During the funded research period, we characterized ORNL IFRC groundwater and sediments in batch microcosm and column experiments conducted at ANL, and we communicated with ANL team members through email and conference calls and face-to-face meetingsmore » at the annual ERSP PI meeting and national meetings. Microcosm test results demonstrated that U(VI) in sediments was reduced to U(IV) when amended with ethanol. The reduced products were not uraninite but unknown U(IV) complexes associated with Fe. Fe(III) in solid phase was only partially reduced. Due to budget reductions at ANL, Stanford contributions ended in 2011.« less

49 CFR 179.200 - General specifications applicable to non-pressure tank car tanks (Class DOT-111).

Code of Federal Regulations, 2013 CFR

2013-10-01

... tank car tanks (Class DOT-111). 179.200 Section 179.200 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

49 CFR 179.200 - General specifications applicable to non-pressure tank car tanks (Class DOT-111).

Code of Federal Regulations, 2014 CFR

2014-10-01

... tank car tanks (Class DOT-111). 179.200 Section 179.200 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

Estimated critical conditions for UO[sub 2]F[sub 2]--H[sub 2]O systems in fully water-reflected spherical geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jordan, W.C.; Turner, J.C.

1992-12-01

The purpose of this report is to document reference calculations performed using the SCALE-4.0 code system to determine the critical parameters of UO[sub 2]F[sub 2]-H[sub 2]O spheres. The calculations are an extension of those documented in ORNL/CSD/TM-284. Specifically, the data for low-enriched UO[sub 2]F[sub 2]-H[sub 2]O spheres have been extended to highly enriched uranium. These calculations, together with those reported in ORNL/CSD/TM-284, provide a consistent set of critical parameters (k[sub [infinity

49 CFR 178.345-1 - General requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... a fillet weld joining the tank shell to a flange shaped to fit the shell contour. (d) A manufacturer... be constructed with the cargo tanks made to the same specification or to different specifications...) Specification DOT 406, DOT 407 and DOT 412 cargo tank motor vehicles must conform to the requirements of this...

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-3E1800. Chlorodifluroethane or 1-Chloro-1, 1-difluoroethane (R-142b) 100 DOT-3A150; DOT-3AA150; DOT-3B150...; DOT-3AL225. Dichlorodifluoromethane and difluoroethane mixture (constant boiling mixture) (R-500) (see...; DOT-4BW240; DOT-4E240; DOT-39. 1,1-Difluoroethane (R-152a) (see note 8) 79 DOT-3A150; DOT-3AA150; DOT...

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-3E1800. Chlorodifluroethane or 1-Chloro-1, 1-difluoroethane (R-142b) 100 DOT-3A150; DOT-3AA150; DOT-3B150...; DOT-3AL225. Dichlorodifluoromethane and difluoroethane mixture (constant boiling mixture) (R-500) (see...; DOT-4BW240; DOT-4E240; DOT-39. 1,1-Difluoroethane (R-152a) (see note 8) 79 DOT-3A150; DOT-3AA150; DOT...

Building a Trustworthy Environmental Science Data Repository: Lessons Learned from the ORNL DAAC

NASA Astrophysics Data System (ADS)

Wei, Y.; Santhana Vannan, S. K.; Boyer, A.; Beaty, T.; Deb, D.; Hook, L.

2017-12-01

The Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC, https://daac.ornl.gov) for biogeochemical dynamics is one of NASA's Earth Observing System Data and Information System (EOSDIS) data centers. The mission of the ORNL DAAC is to assemble, distribute, and provide data services for a comprehensive archive of terrestrial biogeochemistry and ecological dynamics observations and models to facilitate research, education, and decision-making in support of NASA's Earth Science. Since its establishment in 1994, ORNL DAAC has been continuously building itself into a trustworthy environmental science data repository by not only ensuring the quality and usability of its data holdings, but also optimizing its data publication and management process. This paper describes the lessons learned from ORNL DAAC's effort toward this goal. ORNL DAAC has been proactively implementing international community standards throughout its data management life cycle, including data publication, preservation, discovery, visualization, and distribution. Data files in standard formats, detailed documentation, and metadata following standard models are prepared to improve the usability and longevity of data products. Assignment of a Digital Object Identifier (DOI) ensures the identifiability and accessibility of every data product, including the different versions and revisions of its life cycle. ORNL DAAC's data citation policy assures data producers receive appropriate recognition of use of their products. Web service standards, such as OpenSearch and Open Geospatial Consortium (OGC), promotes the discovery, visualization, distribution, and integration of ORNL DAAC's data holdings. Recently, ORNL DAAC began efforts to optimize and standardize its data archival and data publication workflows, to improve the efficiency and transparency of its data archival and management processes.

Data Processing Procedures and Methodology for Estimating Trip Distances for the 1995 American Travel Survey (ATS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hwang, H.-L.; Rollow, J.

2000-05-01

The 1995 American Travel Survey (ATS) collected information from approximately 80,000 U.S. households about their long distance travel (one-way trips of 100 miles or more) during the year of 1995. It is the most comprehensive survey of where, why, and how U.S. residents travel since 1977. ATS is a joint effort by the U.S. Department of Transportation (DOT) Bureau of Transportation Statistics (BTS) and the U.S. Department of Commerce Bureau of Census (Census); BTS provided the funding and supervision of the project, and Census selected the samples, conducted interviews, and processed the data. This report documents the technical support formore » the ATS provided by the Center for Transportation Analysis (CTA) in Oak Ridge National Laboratory (ORNL), which included the estimation of trip distances as well as data quality editing and checking of variables required for the distance calculations.« less

Effectiveness Comparison of TxDOT Quality Control/Quality Assurance and Method Specifications

DOT National Transportation Integrated Search

1998-12-01

Original Report date: October 1997. This is the first and final report for research project 0-1721, "Effectiveness Comparison of TxDOT Quality Control/Quality Assurance and Method Specifications." This study was established and sponsored by TxDOT to ...

The New Online Metadata Editor for Generating Structured Metadata

NASA Astrophysics Data System (ADS)

Devarakonda, R.; Shrestha, B.; Palanisamy, G.; Hook, L.; Killeffer, T.; Boden, T.; Cook, R. B.; Zolly, L.; Hutchison, V.; Frame, M. T.; Cialella, A. T.; Lazer, K.

2014-12-01

Nobody is better suited to "describe" data than the scientist who created it. This "description" about a data is called Metadata. In general terms, Metadata represents the who, what, when, where, why and how of the dataset. eXtensible Markup Language (XML) is the preferred output format for metadata, as it makes it portable and, more importantly, suitable for system discoverability. The newly developed ORNL Metadata Editor (OME) is a Web-based tool that allows users to create and maintain XML files containing key information, or metadata, about the research. Metadata include information about the specific projects, parameters, time periods, and locations associated with the data. Such information helps put the research findings in context. In addition, the metadata produced using OME will allow other researchers to find these data via Metadata clearinghouses like Mercury [1] [2]. Researchers simply use the ORNL Metadata Editor to enter relevant metadata into a Web-based form. How is OME helping Big Data Centers like ORNL DAAC? The ORNL DAAC is one of NASA's Earth Observing System Data and Information System (EOSDIS) data centers managed by the ESDIS Project. The ORNL DAAC archives data produced by NASA's Terrestrial Ecology Program. The DAAC provides data and information relevant to biogeochemical dynamics, ecological data, and environmental processes, critical for understanding the dynamics relating to the biological components of the Earth's environment. Typically data produced, archived and analyzed is at a scale of multiple petabytes, which makes the discoverability of the data very challenging. Without proper metadata associated with the data, it is difficult to find the data you are looking for and equally difficult to use and understand the data. OME will allow data centers like the ORNL DAAC to produce meaningful, high quality, standards-based, descriptive information about their data products in-turn helping with the data discoverability and interoperability.References:[1] Devarakonda, Ranjeet, et al. "Mercury: reusable metadata management, data discovery and access system." Earth Science Informatics 3.1-2 (2010): 87-94. [2] Wilson, Bruce E., et al. "Mercury Toolset for Spatiotemporal Metadata." NASA Technical Reports Server (NTRS) (2010).

ORNL actinide materials and a new detection system for superheavy nuclei

NASA Astrophysics Data System (ADS)

Rykaczewski, Krzysztof P.; Roberto, James B.; Brewer, Nathan T.; Utyonkov, Vladimir K.

2016-12-01

The actinide resources and production capabilities at Oak Ridge National Laboratory (ORNL) are reviewed, including potential electromagnetic separation of rare radioactive materials. The first experiments at the Dubna Gas Filled Recoil Separator (DGFRS) with a new digital detection system developed at ORNL and University of Tennessee Knoxville (UTK) are presented. These studies used 240Pu material provided by ORNL and mixed-Cf targets made at ORNL. The proposal to use an enriched 251Cf target and a large dose of 58Fe beam to reach the N = 184 shell closure and to observe new elements with Z = 124, 122 and 120 is discussed.

Biological and Environmental Research Program at Oak Ridge National Laboratory, FY 1992--1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report is the 1992--1994 Program Director's Overview Report for Oak Ridge National Laboratory's (ORNL's) Biological and Environmental Research (BER) Program, and as such it addresses KP-funded work at ORNL conducted during FY 1991 and in progress during FY 1992; it also serves as a planning document for the remainder of FY 1992 through FY 1994. Non-BER funded work at ORNL relevant to the mission of OHER is also discussed. The second section of the report describes ORNL facilities and resources used by the BER program. The third section addresses research management practices at ORNL. The fourth, fifth, and sixthmore » sections address BER-funded research in progress, program accomplishments and research highlights, and program orientation for the remainder of FY 1992 through FY 1994, respectively. Work for non-BER sponsors is described in the seventh section, followed by a discussion of significant near and long-term issues facing BER work at ORNL in the eighth section. The last section provides a statistical summary of BER research at ORNL. Appendices supplement the above topics with additional detail.« less

Oak Ridge TNS Program: system description manual

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reid, R.L.; Becraft, W.R.; Brown, T.G.

1979-05-01

This document provides a systems description of the Reference Design for The Next Step (TNS) evolved at Oak Ridge National Laboratory (ORNL) during FY 1978. The description is presented on the basis of 24 individual device and facility systems. Additional information on these systems, the Reference Design, and the FY 1978 Oak Ridge TNS activities can be found in the associated technical memoranda, ORNL/TM-6720 and ORNL/TM-6722--ORNL/TM-6733.

Production and testing of the ENEA-Bologna VITJEFF32.BOLIB (JEFF-3.2) multi-group (199 n + 42 γ) cross section library in AMPX format for nuclear fission applications

NASA Astrophysics Data System (ADS)

Pescarini, Massimo; Orsi, Roberto; Frisoni, Manuela

2017-09-01

The ENEA-Bologna Nuclear Data Group produced the VITJEFF32.BOLIB multi-group coupled neutron/photon (199 n + 42 γ) cross section library in AMPX format, based on the OECD-NEA Data Bank JEFF-3.2 evaluated nuclear data library. VITJEFF32.BOLIB was conceived for nuclear fission applications as European counterpart of the ORNL VITAMIN-B7 similar library (ENDF/B-VII.0 data). VITJEFF32.BOLIB has the same neutron and photon energy group structure as the former ORNL VITAMIN-B6 reference library (ENDF/B-VI.3 data) and was produced using similar data processing methodologies, based on the LANL NJOY-2012.53 nuclear data processing system for the generation of the nuclide cross section data files in GENDF format. Then the ENEA-Bologna 2007 Revision of the ORNL SCAMPI nuclear data processing system was used for the conversion into the AMPX format. VITJEFF32.BOLIB contains processed cross section data files for 190 nuclides, obtained through the Bondarenko (f-factor) method for the treatment of neutron resonance self-shielding and temperature effects. Collapsed working libraries of self-shielded cross sections in FIDO-ANISN format, used by the deterministic transport codes of the ORNL DOORS system, can be generated from VITJEFF32.BOLIB through the cited SCAMPI version. This paper describes the methodology and specifications of the data processing performed and presents some results of the VITJEFF32.BOLIB validation.

49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

Code of Federal Regulations, 2013 CFR

2013-10-01

... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

Code of Federal Regulations, 2011 CFR

2011-10-01

... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

Code of Federal Regulations, 2010 CFR

2010-10-01

... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

Code of Federal Regulations, 2014 CFR

2014-10-01

... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

ORNLs Laboratory Directed Research and Development Program FY 2009 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2010-03-01

The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2009. The associated FY 2009 ORNL LDRD Self-Assessment (ORNL/PPA-2010/2) provides financial data andmore » an internal evaluation of the program’s management process.« less

ORNLs Laboratory Directed Research and Development Program FY 2013 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2014-03-01

The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the US Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2013. The associated FY 2013 ORNL LDRD Self-Assessment (ORNL/PPA-2014/2) provides financial datamore » and an internal evaluation of the program’s management process.« less

ORNLs Laboratory Directed Research and Development Program FY 2008 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2009-03-01

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2008. The associated FY 2008 ORNL LDRD Self-Assessment (ORNL/PPA-2008/2) provides financial data and anmore » internal evaluation of the program’s management process.« less

ORNLs Laboratory Directed Research and Development Program FY 2012 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

2013-03-01

The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the US Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2012. The associated FY 2012 ORNL LDRD Self-Assessment (ORNL/PPA-2012/2) provides financial datamore » and an internal evaluation of the program’s management process.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nichols, Teresa A.; Lapsa, Melissa Voss

Oak Ridge National Laboratory (ORNL) is both the largest science and energy laboratory of the US Department of Energy (DOE) and one of the oldest national laboratories still operating at its original site. These characteristics provide the Sustainable Campus Initiative (SCI) both a unique opportunity and a unique challenge to integrate sustainability into facilities and activities. As outlined in this report, SCI is leveraging the outcomes of ORNL’s DOE-sponsored research and development programs to maximize the efficient use of energy and natural resources across ORNL. Wherever possible, ORNL is integrating technical innovations into new and existing facilities, systems, and processesmore » with a widespread approach to achieving Executive Order 13514. ORNL continues to pursue and deploy innovative solutions and initiatives to advance regional, national, and worldwide sustainability and continues to transform its culture and engage employees in supporting sustainability at work, at home, and in the community. Table 1 summarizes ORNL's FY 2013 performance and planned actions to attain future goals. ORNL has achieved numerous successes during FY 2013, which are described in detail throughout this document.« less

Oak Ridge National Laboratory: Sustainable Landscapes Initiative 2020

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardner, Leah; Rogers, Sam; Sipes, James L.

The goal of the ORNL Sustainable Landscapes Initiative 2020 is to provide a framework that guides future environmental resources and sustainable landscape practices on the ORNL campus. This document builds on the 2003 ORNL Conceptual Landscape Plan and is presented in the context of embracing new opportunities.

49 CFR 178.346 - Specification DOT 406; cargo tank motor vehicle.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Specification DOT 406; cargo tank motor vehicle. 178.346 Section 178.346 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for...

49 CFR 178.348 - Specification DOT 412; cargo tank motor vehicle.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Specification DOT 412; cargo tank motor vehicle. 178.348 Section 178.348 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for...

49 CFR 178.347 - Specification DOT 407; cargo tank motor vehicle.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Specification DOT 407; cargo tank motor vehicle. 178.347 Section 178.347 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for...

Fusion Materials Research at Oak Ridge National Laboratory in Fiscal Year 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiffen, Frederick W; Katoh, Yutai; Melton, Stephanie G.

2016-12-01

This document summarizes FY2016 activities supporting the Office of Science, Office of Fusion Energy Sciences Materials Research for MFE carried out by ORNL. The organization of the report is mainly by material type, with sections on specific technical activities.

Gas-cooled reactor programs. High-temperature gas-cooled reactor technology development program. Annual progress report, December 31, 1983

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kasten, P.R.; Rittenhouse, P.L.; Bartine, D.E.

1984-06-01

ORNL continues to make significant contributions to the national program. In the HTR fuels area, we are providing detailed statistical information on the fission product retention performance of irradiated fuel. Our studies are also providing basic data on the mechanical, physical, and chemical behavior of HTR materials, including metals, ceramics, graphite, and concrete. The ORNL has an important role in the development of improved HTR graphites and in the specification of criteria that need to be met by commercial products. We are also developing improved reactor physics design methods. Our work in component development and testing centers in the Componentmore » Flow Test Loop (CFTL), which is being used to evaluate the performance of the HTR core support structure. Other work includes experimental evaluation of the shielding effectiveness of the lower portions of an HTR core. This evaluation is being performed at the ORNL Tower Shielding Facility. Researchers at ORNL are developing welding techniques for attaching steam generator tubing to the tubesheets and are testing ceramic pads on which the core posts rest. They are also performing extensive testing of aggregate materials obtained from potential HTR site areas for possible use in prestressed concrete reactor vessels. During the past year we continued to serve as a peer reviewer of small modular reactor designs being developed by GA and GE with balance-of-plant layouts being developed by Bechtel Group, Inc. We have also evaluated the national need for developing HTRs with emphasis on the longer term applications of the HTRs to fossil conversion processes.« less

Semi-automated Data Set Submission Work Flow for Archival with the ORNL DAAC

NASA Astrophysics Data System (ADS)

Wright, D.; Beaty, T.; Cook, R. B.; Devarakonda, R.; Eby, P.; Heinz, S. L.; Hook, L. A.; McMurry, B. F.; Shanafield, H. A.; Sill, D.; Santhana Vannan, S.; Wei, Y.

2013-12-01

The ORNL DAAC archives and publishes, free of charge, data and information relevant to biogeochemical, ecological, and environmental processes. The ORNL DAAC primarily archives data produced by NASA's Terrestrial Ecology Program; however, any data that are pertinent to the biogeochemical and ecological community are of interest. The data set submission process to the ORNL DAAC has been recently updated and semi-automated to provide a consistent data provider experience and to create a uniform data product. The data archived at the ORNL DAAC must be well formatted, self-descriptive, and documented, as well as referenced in a peer-reviewed publication. If the ORNL DAAC is the appropriate archive for a data set, the data provider will be sent an email with several URL links to guide them through the submission process. The data provider will be asked to fill out a short online form to help the ORNL DAAC staff better understand the data set. These questions cover information about the data set, a description of the data set, temporal and spatial characteristics of the data set, and how the data were prepared and delivered. The questionnaire is generic and has been designed to gather input on the various diverse data sets the ORNL DAAC archives. A data upload module and metadata editor further guide the data provider through the submission process. For submission purposes, a complete data set includes data files, document(s) describing data, supplemental files, metadata record(s), and an online form. There are five major functions the ORNL DAAC performs during the process of archiving data: 1) Ingestion is the ORNL DAAC side of submission; data are checked, metadata records are compiled, and files are converted to archival formats. 2) Metadata records and data set documentation made searchable and the data set is given a permanent URL. 3) The data set is published, assigned a DOI, and advertised. 4) The data set is provided long-term post-project support. 5) Stewardship of data ensures the data are stored on state of the art computer systems with reliable backups.

Short guide to SDI profiling at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pomerance, H.S.

1976-06-01

ORNL has machine-searchable data bases that correspond to printed indexes and abstracts. This guide describes the peculiarities of those several data bases and the conventions of the ORNL search system so that users can write their own queries or search profiles and can interpret the part of the output that is encoded.

Viability of thin wall tube forming of ATF FeCrAl

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maloy, Stuart Andrew; Aydogan, Eda; Anderoglu, Osman

Fabrication of thin walled tubing of FeCrAl alloys is critical to its success as a candidate enhanced accident-tolerant fuel cladding material. Alloys that are being investigated are Generation I and Generation II FeCrAl alloys produced at ORNL and an ODS FeCrAl alloy, MA-956 produced by Special Metals. Gen I and Gen II FeCrAl alloys were provided by ORNL and MA-956 was provided by LANL (initially produced by Special Metals). Three tube development efforts were undertaken. ORNL led the FeCrAl Gen I and Gen II alloy development and tube processing studies through drawing tubes at Rhenium Corporation. LANL received alloys frommore » ORNL and led tube processing studies through drawing tubes at Century Tubing. PNNL led the development of tube processing studies on MA-956 through pilger processing working with Sandvik Corporation. A summary of the recent progress on tube development is provided in the following report and a separate ORNL report: ORNL/TM-2015/478, “Development and Quality Assessments of Commercial Heat Production of ATF FeCrAl Tubes”.« less

Crash Models for Advanced Automotive Batteries: A Review of the Current State of the Art

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, John A.; Allu, Srikanth; Gorti, Sarma B.

Safety is a critical aspect of lithium-ion (Li-ion) battery design. Impact/crash conditions can trigger a complex interplay of mechanical contact, heat generation and electrical discharge, which can result in adverse thermal events. The cause of these thermal events has been linked to internal contact between the opposite electrodes, i.e. internal short circuit. The severity of the outcome is influenced by the configuration of the internal short circuit and the battery state. Different loading conditions and battery states may lead to micro (soft) shorts where material burnout due to generated heat eliminates contact between the electrodes, or persistent (hard) shorts whichmore » can lead to more significant thermal events and potentially damage the entire battery system and beyond. Experimental characterization of individual battery components for the onset of internal shorts is limited, since it is impractical to canvas all possible variations in battery state of charge, operating conditions, and impact loading in a timely manner. This report provides a survey of modeling and simulation approaches and documents a project initiated and funded by DOT/NHTSA to improve modeling and simulation capabilities in order to design tests that provide leading indicators of failure in batteries. In this project, ORNL has demonstrated a computational infrastructure to conduct impact simulations of Li-ion batteries using models that resolve internal structures and electro-thermo-chemical and mechanical conditions. Initial comparisons to abuse experiments on cells and cell strings conducted at ORNL and Naval Surface Warfare Center (NSWC) at Carderock MD for parameter estimation and model validation have been performed. This research has provided insight into the mechanisms of deformation in batteries (both at cell and electrode level) and their relationship to the safety of batteries.« less

Atlas-based head modeling and spatial normalization for high-density diffuse optical tomography: in vivo validation against fMRI.

PubMed

Ferradal, Silvina L; Eggebrecht, Adam T; Hassanpour, Mahlega; Snyder, Abraham Z; Culver, Joseph P

2014-01-15

Diffuse optical imaging (DOI) is increasingly becoming a valuable neuroimaging tool when fMRI is precluded. Recent developments in high-density diffuse optical tomography (HD-DOT) overcome previous limitations of sparse DOI systems, providing improved image quality and brain specificity. These improvements in instrumentation prompt the need for advancements in both i) realistic forward light modeling for accurate HD-DOT image reconstruction, and ii) spatial normalization for voxel-wise comparisons across subjects. Individualized forward light models derived from subject-specific anatomical images provide the optimal inverse solutions, but such modeling may not be feasible in all situations. In the absence of subject-specific anatomical images, atlas-based head models registered to the subject's head using cranial fiducials provide an alternative solution. In addition, a standard atlas is attractive because it defines a common coordinate space in which to compare results across subjects. The question therefore arises as to whether atlas-based forward light modeling ensures adequate HD-DOT image quality at the individual and group level. Herein, we demonstrate the feasibility of using atlas-based forward light modeling and spatial normalization methods. Both techniques are validated using subject-matched HD-DOT and fMRI data sets for visual evoked responses measured in five healthy adult subjects. HD-DOT reconstructions obtained with the registered atlas anatomy (i.e. atlas DOT) had an average localization error of 2.7mm relative to reconstructions obtained with the subject-specific anatomical images (i.e. subject-MRI DOT), and 6.6mm relative to fMRI data. At the group level, the localization error of atlas DOT reconstruction was 4.2mm relative to subject-MRI DOT reconstruction, and 6.1mm relative to fMRI. These results show that atlas-based image reconstruction provides a viable approach to individual head modeling for HD-DOT when anatomical imaging is not available. Copyright © 2013. Published by Elsevier Inc.

Bat Acoustic Survey Report for ORNL: Bat Species Distribution on the Oak Ridge Reservation

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCracken, Kitty; Giffen, Neil R.; Haines, Angelina

This report summarizes results of a three-year acoustic survey of bat species on the US Department of Energy (DOE) Oak Ridge Reservation (ORR) in Oak Ridge, Tennessee. The survey was implemented through the Oak Ridge National Laboratory (ORNL) Natural Resources Management Program and included researchers from the ORNL Environmental Sciences Division and ORNL Facilities and Operations Directorate, Tennessee Wildlife Resources Agency’s ORR wildlife manager, a student from Tennessee Technological University, and a technician contracted through Excel Corp. One hundred and twenty-six sites were surveyed reservation-wide using Wildlife Acoustics SM2+ Acoustic Bat Detectors.

Year One Summary of X-energy Pebble Fuel Development at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmreich, Grant W.; Hunn, John D.; McMurray, Jake W.

2017-06-01

The Advanced Reactor Concepts X-energy (ARC-Xe) Pebble Fuel Development project at Oak Ridge National Laboratory (ORNL) has successfully completed its first year, having made excellent progress in accomplishing programmatic objectives. The primary focus of research at ORNL in support of X-energy has been the training of X-energy fuel fabrication engineers and the establishment of US pebble fuel production capabilities able to supply the Xe-100 pebble-bed reactor. These efforts have been strongly supported by particle fuel fabrication and characterization expertise present at ORNL from the Advanced Gas Reactor (AGR) Fuel Development and Qualification Program.

Estimated critical conditions for UO{sub 2}F{sub 2}--H{sub 2}O systems in fully water-reflected spherical geometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jordan, W.C.; Turner, J.C.

1992-12-01

The purpose of this report is to document reference calculations performed using the SCALE-4.0 code system to determine the critical parameters of UO{sub 2}F{sub 2}-H{sub 2}O spheres. The calculations are an extension of those documented in ORNL/CSD/TM-284. Specifically, the data for low-enriched UO{sub 2}F{sub 2}-H{sub 2}O spheres have been extended to highly enriched uranium. These calculations, together with those reported in ORNL/CSD/TM-284, provide a consistent set of critical parameters (k{sub {infinity}}, volume, mass, mass of water) for UO{sub 2}F{sub 2} and water over the full range of enrichment and moderation ratio.

Luminescent Quantum Dots as Ultrasensitive Biological Labels

NASA Astrophysics Data System (ADS)

Nie, Shuming

2000-03-01

Highly luminescent semiconductor quantum dots have been covalently coupled to biological molecules for use in ultrasensitive biological detection. This new class of luminescent labels is considerably brighter and more resistant againt photobleaching in comparison with organic dyes. Quantum dots labeled with the protein transferrin undergo receptor-mediated endocytosis (RME) in cultured HeLa cells, and those dots that were conjugated to immunomolecules recognize specific antibodies or antigens. In addition, we show that DNA functionalized quantum dots can be used to target specific genes by hybridization. We expect that quantum dot bioconjugates will have a broad range of biological applications, such as ligand-receptor interactions, real-time monitoring of molecular trafficking inside living cells, multicolor fluorescence in-situ hybridization (FISH), high-sensitivity detection in miniaturized devices (e.g., DNA chips), and fluorescent tagging of combinatorial chemical libraries. A potential clinical application is the use of quantum dots for ultrasensitive viral RNA detection, in which as low as 100 copies of hepatitis C and HIV viruses per ml blood should be detected.

Environmental analysis of the operation of Oak Ridge National Laboratory (X-10 site)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyle, J.W.; Blumberg, R.; Cotter, S.J.

1982-11-01

An environmental analysis of the operation of the Oak Ridge National Laboratory (ORNL) facilities in Bethel Valley and Melton Valley was conducted to present to the public information concerning the extent to which recognizable effects, or potential effects, on the environment may occur. The analysis addresses current operations of the ORNL X-10 site and completed operations that may continue to have residual effects. Solid wastes from ORNL operations at the Y-12 site which are transported to the X-10 site for burial (e.g., Biology Division animal wastes) are included as part of X-10 site operation. Socioeconomic effects are associated primarily withmore » the communities where employees live and with the Knoxville Bureau of Economic Analysis economic area as a whole. Therefore, ORNL employees at both Y-12 and X-10 sites are included in the ORNL socioeconomic impact analysis. An extensive base of environmental data was accumulated for this report. Over 80 reports related to ORNL facilities and/or operations are cited as well as many open-literature citations. Environmental effects of the operation of ORNL result from operational discharges from the onsite facilities; construction and/or modification of facilities, transportation to and from the site of persons, goods and services; socioeconomic impacts to the local, regional, and general population; and accidental discharges if they should occur. Operational discharges to the environnment are constrained by federal, state, and local regulations and by criteria established by the US Department of Energy to minimize adverse impacts. It is the purpose of this document to evaluate the operation of the ORNL insofar as impacts beyond the site boundary may occur or have the potential for occurrence.« less

WUFI (Wärme and Feuchte Instationär)-Oak Ridge National Laboratory (ORNL)/Fraunhofer IBP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manfred Kehrer, ORNL

2014-05-20

WUFI - Oak Ridge National Laboratory (ORNL)/Fraunhofer IBP is a menu-driven PC program which allows realistic calculation of the transient coupled one-dimensional heat and moisture transport in multi-layer building components exposed to natural weather. It is based on the newest findings regarding vapor diffusion and liquid transport in building materials and has been validated by detailed comparison with measurements obtained in the laboratory and on outdoor testing fields. Together with Oak Ridge National Laboratory (ORNL) Fraunhofer IBP has developed a special version of WUFI ® for North America. WUFI® ORNL is a functionally limited free version of WUFI® Pro formore » non-commercial purposes. It contains climate data for 62 cities in the USA and Canada which are all available in the free version. http://web.ornl.gov/sci/ees/etsd/btric/wufi/ http://www.WUFI.com/ORNL« less

ORNL Sustainable Campus Initiative

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halford, Christopher K

2012-01-01

The research conducted at Oak Ridge National Laboratory (ORNL) spans many disciplines and has the potential for far-reaching impact in many areas of everyday life. ORNL researchers and operations staff work on projects in areas as diverse as nuclear power generation, transportation, materials science, computing, and building technologies. As the U.S. Department of Energy s (DOE) largest science and energy research facility, ORNL seeks to establish partnerships with industry in the development of innovative new technologies. The primary focus of this current research deals with developing technologies which improve or maintain the quality of life for humans while reducing themore » overall impact on the environment. In its interactions with industry, ORNL serves as both a facility for sustainable research, as well as a representative of DOE to the private sector. For these reasons it is important that the everyday operations of the Laboratory reflect a dedication to the concepts of stewardship and sustainability.« less

Has the DOTS Strategy Improved Case Finding or Treatment Success? An Empirical Assessment

PubMed Central

Obermeyer, Ziad; Abbott-Klafter, Jesse; Murray, Christopher J. L.

2008-01-01

Background Nearly fifteen years after the start of WHO's DOTS strategy, tuberculosis remains a major global health problem. Given the lack of empirical evidence that DOTS reduces tuberculosis burden, considerable debate has arisen about its place in the future of global tuberculosis control efforts. An independent evaluation of DOTS, one of the most widely-implemented and longest-running interventions in global health, is a prerequisite for meaningful improvements to tuberculosis control efforts, including WHO's new Stop TB Strategy. We investigate the impact of the expansion of the DOTS strategy on tuberculosis case finding and treatment success, using only empirical data. Methods and Findings We study the effect of DOTS using time-series cross-sectional methods. We first estimate the impact of DOTS expansion on case detection, using reported case notification data and controlling for other determinants of change in notifications, including HIV prevalence, GDP, and country-specific effects. We then estimate the effect of DOTS expansion on treatment success. DOTS programme variables had no statistically significant impact on case detection in a wide range of models and specifications. DOTS population coverage had a significant effect on overall treatment success rates, such that countries with full DOTS coverage benefit from at least an 18% increase in treatment success (95% CI: 5–31%). Conclusions The DOTS technical package improved overall treatment success. By contrast, DOTS expansion had no effect on case detection. This finding is less optimistic than previous analyses. Better epidemiological and programme data would facilitate future monitoring and evaluation efforts. PMID:18320042

49 CFR 179.200 - General specifications applicable to non-pressure tank car tanks (Class DOT-111).

Code of Federal Regulations, 2010 CFR

2010-10-01

... tank car tanks (Class DOT-111). 179.200 Section 179.200 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes...

49 CFR 179.400-24 - Stamping.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400... of required stamping Specification DOT-113A60W. Design service temperature Minus 423° F. Inner tank...

Results of a Pilot-Scale Disinfection Test using Peracetic Acid (PAA) at the Oak Ridge National Laboratory (ORNL) Sewage Treatment Plant (STP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Paul Allen

The purpose of this report is to present the results of a small pilot-scale test using PAA to disinfect a side stream of the effluent from the ORNL STP. These results provide the basis for requesting approval for full-scale use of PAA at the ORNL STP.

Hydraulic manipulator research at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kress, R.L.; Jansen, J.F.; Love, L.J.

1997-03-01

Recently, task requirements have dictated that manipulator payload capacity increase to accommodate greater payloads, greater manipulator length, and larger environmental interaction forces. General tasks such as waste storage tank cleanup and facility dismantlement and decommissioning require manipulator life capacities in the range of hundreds of pounds rather than tens of pounds. To meet the increased payload capacities demanded by present-day tasks, manipulator designers have turned once again to hydraulics as a means of actuation. In order to successfully design, build, and deploy a new hydraulic manipulator (or subsystem), sophisticated modeling, analysis, and control experiments are usually needed. Oak Ridge Nationalmore » Laboratory (ORNL) has a history of projects that incorporate hydraulics technology, including mobile robots, teleoperated manipulators, and full-scale construction equipment. In addition, to support the development and deployment of new hydraulic manipulators, ORNL has outfitted a significant experimental laboratory and has developed the software capability for research into hydraulic manipulators, hydraulic actuators, hydraulic systems, modeling of hydraulic systems, and hydraulic controls. The purpose of this article is to describe the past hydraulic manipulator developments and current hydraulic manipulator research capabilities at ORNL. Included are example experimental results from ORNL`s flexible/prismatic test stand.« less

Photoluminescent carbon dots based on a rare 3D inorganic-organic hybrid cadmium borate crystal.

PubMed

Zhou, Kang; Zhang, Wen-Jin; Luo, Yuan-Zhang; Pan, Chun-Yang

2018-05-17

A 3D inorganic-organic hybridized skeleton cadmium borate [Cden][B5O8(OH)] (1) (en = ethylenediamine) has been solvothermally synthesized. By calcining it, specific shape carbon dots (C-dots) with abundant free radicals were observed. In addition, C-dots in the ethanol phase exhibited variable photoluminescence and showed rare turn on or off effects to Cr3+ ions and CdSe/ZnS quantum dots, but only a turn on effect to Cs+ ions and a turn off effect to CsPbBr3 quantum dots.

WAG 2 remedial investigation and site investigation site-specific work plan/health and safety checklist for the soil and sediment task. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holt, V.L.; Burgoa, B.B.

1993-12-01

This document is a site-specific work plan/health and safety checklist (WP/HSC) for a task of the Waste Area Grouping 2 Remedial Investigation and Site Investigation (WAG 2 RI&SI). Title 29 CFR Part 1910.120 requires that a health and safety program plan that includes site- and task-specific information be completed to ensure conformance with health- and safety-related requirements. To meet this requirement, the health and safety program plan for each WAG 2 RI&SI field task must include (1) the general health and safety program plan for all WAG 2 RI&SI field activities and (2) a WP/HSC for that particular field task.more » These two components, along with all applicable referenced procedures, must be kept together at the work site and distributed to field personnel as required. The general health and safety program plan is the Health and Safety Plan for the Remedial Investigation and Site Investigation of Waste Area Grouping 2 at the Oak Ridge National Laboratory, Oak Ridge, Tennessee (ORNL/ER-169). The WP/HSCs are being issued as supplements to ORNL/ER-169.« less

Field sampling and analysis plan for the remedial investigation of Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Environmental Restoration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boston, H.L.; Ashwood, T.L.; Borders, D.M.

1992-02-01

This field sampling and analysis (S & A) plan has been developed as part of the Department of Energy`s (DOE`s) remedial investigation (RI) of Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL) located in Oak Ridge, Tennessee. The S & A plan has been written in support of the remedial investigation (RI) plan for WAG 2 (ORNL 1990). WAG 2 consists of White Oak Creek (WOC) and its tributaries downstream of the ORNL main plant area, White Oak Lake (WOL), White Oak Creek embayment (WOCE) on the Clinch River, and the associated floodplain and subsurface environment (Fig.more » 1.1). The WOC system is the surface drainage for the major ORNL WAGs and has been exposed to a diversity of contaminants from operations and waste disposal activities in the WOC watershed. WAG 2 acts as a conduit through which hydrologic fluxes carry contaminants from upgradient areas to the Clinch River. Water, sediment, soil, and biota in WAG 2 are contaminated and continue to receive contaminants from upgradient WAGs. This document describes the following: an overview of the RI plan, background information for the WAG 2 system, and objectives of the S & A plan; the scope and implementation of the first 2 years of effort of the S & A plan and includes recent information about contaminants of concern, organization of S & A activities, interactions with other programs, and quality assurance specific to the S & A activities; provides details of the field sampling plans for sediment, surface water, groundwater, and biota, respectively; and describes the sample tracking and records management plan.« less

Instrumentation and Controls Division progress report for the period July 1, 1986 to June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klobe, L.E.

1988-12-01

The Instrumentation and Controls (IandC) Division of Oak Ridge National Laboratory (ORNL) performs basic and applied instrumentation and controls research, development and design engineering, specialized instrument design and fabrication, and maintenance services for instruments, electronics, and computers. The IandC Division is one of the largest RandD organizations of its type among government laboratories, and it exists as the result of an organizational strategy to integrate ORNL's instrumentation and controls-related disciplines into one dedicated functional organization to increase the Laboratory's expertise and capabilities in these rapidly expanding, innovative areas of technology. The Division participates in the programs and projects of ORNLmore » by applying its expertise and capabilities in concert with other divisions to perform basic research and mission-oriented technology development. Many of the Division's RandD tasks that are a part of a larger ORNL program are of sufficient scope that the IandC effort constitutes a separate program element with direct funding and management responsibility within the Division. The activities of IandC include performance of an RandD task in IandC facilities, the participation of from one of many IandC engineers and scientists in a multidisciplinary team working in a specific research area or development project, design and fabrication of a special instrument or instrumentation system, or a few hours of maintenance service. In its support and maintenance work, the role of the IandC Division is to provide a level of expertise appropriate to complete a job successfully at minimum overall cost and time schedule---a role which involves IandC in almost all ORNL activities.« less

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications.

PubMed

Ellis, Matthew A; Grandinetti, Giovanna; Fichter, Katye M; Fichter, Kathryn M

2016-02-06

Fluorescent nanocrystals, specifically quantum dots, have been a useful tool for many biomedical applications. For successful use in biological systems, quantum dots should be highly fluorescent and small/monodisperse in size. While commonly used cadmium-based quantum dots possess these qualities, they are potentially toxic due to the possible release of Cd(2+) ions through nanoparticle degradation. Indium-based quantum dots, specifically InP/ZnS, have recently been explored as a viable alternative to cadmium-based quantum dots due to their relatively similar fluorescence characteristics and size. The synthesis presented here uses standard hot-injection techniques for effective nanoparticle growth; however, nanoparticle properties such as size, emission wavelength, and emission intensity can drastically change due to small changes in the reaction conditions. Therefore, reaction conditions such temperature, reaction duration, and precursor concentration should be maintained precisely to yield reproducible products. Because quantum dots are not inherently soluble in aqueous solutions, they must also undergo surface modification to impart solubility in water. In this protocol, an amphiphilic polymer is used to interact with both hydrophobic ligands on the quantum dot surface and bulk solvent water molecules. Here, a detailed protocol is provided for the synthesis of highly fluorescent InP/ZnS quantum dots that are suitable for use in biomedical applications.

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

PubMed Central

Ellis, Matthew A.; Grandinetti, Giovanna; Fichter, Katye M.

2016-01-01

Fluorescent nanocrystals, specifically quantum dots, have been a useful tool for many biomedical applications. For successful use in biological systems, quantum dots should be highly fluorescent and small/monodisperse in size. While commonly used cadmium-based quantum dots possess these qualities, they are potentially toxic due to the possible release of Cd2+ ions through nanoparticle degradation. Indium-based quantum dots, specifically InP/ZnS, have recently been explored as a viable alternative to cadmium-based quantum dots due to their relatively similar fluorescence characteristics and size. The synthesis presented here uses standard hot-injection techniques for effective nanoparticle growth; however, nanoparticle properties such as size, emission wavelength, and emission intensity can drastically change due to small changes in the reaction conditions. Therefore, reaction conditions such temperature, reaction duration, and precursor concentration should be maintained precisely to yield reproducible products. Because quantum dots are not inherently soluble in aqueous solutions, they must also undergo surface modification to impart solubility in water. In this protocol, an amphiphilic polymer is used to interact with both hydrophobic ligands on the quantum dot surface and bulk solvent water molecules. Here, a detailed protocol is provided for the synthesis of highly fluorescent InP/ZnS quantum dots that are suitable for use in biomedical applications. PMID:26891282

Photoluminescent carbon dots synthesized by microwave treatment for selective image of cancer cells.

PubMed

Yang, Xudong; Yang, Xue; Li, Zhenyu; Li, Shouying; Han, Yexuan; Chen, Yang; Bu, Xinyuan; Su, Chunyan; Xu, Hong; Jiang, Yingnan; Lin, Quan

2015-10-15

In this work, a simple, low-cost and one-step microwave approach has been demonstrated for the synthesis of water-soluble carbon dots (C-dots). The average size of the resulting C-dots is about 4 nm. From the photoluminescence (PL) measurements, the C-dots exhibit excellent biocompatibility and intense PL with the high quantum yield (QY) at Ca. 25%. Significantly, the C-dots have excellent biocompatibility and the capacity to specifically target the cells overexpressing the folate receptor (FR). These exciting results indicate the as-prepared C-dots are promising biocompatible probe for cancer diagnosis and treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

Directly observed therapy reduces tuberculosis-specific mortality: a population-based follow-up study in Taipei, Taiwan.

PubMed

Yen, Yung-Feng; Yen, Muh-Yong; Lin, Yi-Ping; Shih, Hsiu-Chen; Li, Lan-Huei; Chou, Pesus; Deng, Chung-Yeh

2013-01-01

To determine the effect of directly observed therapy (DOT) on tuberculosis-specific mortality and non-TB-specific mortality and identify prognostic factors associated with mortality among adults with culture-positive pulmonary TB (PTB). All adult Taiwanese with PTB in Taipei, Taiwan were included in a retrospective cohort study in 2006-2010. Backward stepwise multinomial logistic regression was used to identify risk factors associated with each mortality outcome. Mean age of the 3,487 patients was 64.2 years and 70.4% were male. Among 2471 patients on DOT, 4.2% (105) died of TB-specific causes and 15.4% (381) died of non-TB-specific causes. Among 1016 patients on SAT, 4.4% (45) died of TB-specific causes and 11.8% (120) died of non-TB-specific causes. , After adjustment for potential confounders, the odds ratio for TB-specific mortality was 0.45 (95% CI: 0.30-0.69) among patients treated with DOT as compared with those on self-administered treatment. Independent predictors of TB-specific and non-TB-specific mortality included older age (ie, 65-79 and ≥80 years vs. 18-49 years), being unemployed, a positive sputum smear for acid-fast bacilli, and TB notification from a general ward or intensive care unit (reference: outpatient services). Male sex, end-stage renal disease requiring dialysis, malignancy, and pleural effusion on chest radiography were associated with increased risk of non-TB-specific mortality, while presence of lung cavities on chest radiography was associated with lower risk. DOT reduced TB-specific mortality by 55% among patients with PTB, after controlling for confounders. DOT should be given to all TB patients to further reduce TB-specific mortality.

Directly Observed Therapy Reduces Tuberculosis-Specific Mortality: A Population-Based Follow-Up Study in Taipei, Taiwan

PubMed Central

Yen, Yung-Feng; Yen, Muh-Yong; Lin, Yi-Ping; Shih, Hsiu-Chen; Li, Lan-Huei; Chou, Pesus; Deng, Chung-Yeh

2013-01-01

Objectives To determine the effect of directly observed therapy (DOT) on tuberculosis-specific mortality and non-TB-specific mortality and identify prognostic factors associated with mortality among adults with culture-positive pulmonary TB (PTB). Methods All adult Taiwanese with PTB in Taipei, Taiwan were included in a retrospective cohort study in 2006–2010. Backward stepwise multinomial logistic regression was used to identify risk factors associated with each mortality outcome. Results Mean age of the 3,487 patients was 64.2 years and 70.4% were male. Among 2471 patients on DOT, 4.2% (105) died of TB-specific causes and 15.4% (381) died of non-TB-specific causes. Among 1016 patients on SAT, 4.4% (45) died of TB-specific causes and 11.8% (120) died of non-TB-specific causes. , After adjustment for potential confounders, the odds ratio for TB-specific mortality was 0.45 (95% CI: 0.30–0.69) among patients treated with DOT as compared with those on self-administered treatment. Independent predictors of TB-specific and non-TB-specific mortality included older age (ie, 65–79 and ≥80 years vs. 18–49 years), being unemployed, a positive sputum smear for acid-fast bacilli, and TB notification from a general ward or intensive care unit (reference: outpatient services). Male sex, end-stage renal disease requiring dialysis, malignancy, and pleural effusion on chest radiography were associated with increased risk of non-TB-specific mortality, while presence of lung cavities on chest radiography was associated with lower risk. Conclusions DOT reduced TB-specific mortality by 55% among patients with PTB, after controlling for confounders. DOT should be given to all TB patients to further reduce TB-specific mortality. PMID:24278152

ORNL (Oak Ridge National Laboratory) 89

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, T.D.; Appleton, B.R.; Jefferson, J.W.

This is the inaugural issues of an annual publication about the Oak Ridge National Laboratory. Here you will find a brief overview of ORNL, a sampling of our recent research achievements, and a glimpse of the directions we want to take over the next 15 years. A major purpose of ornl 89 is to provide the staff with a sketch of the character and dynamics of the Laboratory.

The Coming Nuclear Renaissance for Next Generation Safeguards Specialists--Maximizing Potential and Minimizing the Risks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eipeldauer, Mary D

2009-01-01

This document is intended to provide an overview of the workshop entitled 'The Coming Nuclear Renaissance for the Next Generation Safeguards Experts-Maximizing Benefits While Minimizing Proliferation Risks', conducted at Oak Ridge National Laboratory (ORNL) in partnership with the Y-12 National Security Complex (Y-12) and the Savannah River National Laboratory (SRNL). This document presents workshop objectives; lists the numerous participant universities and individuals, the nuclear nonproliferation lecture topics covered, and the facilities tours taken as part of the workshop; and discusses the university partnership sessions and proposed areas for collaboration between the universities and ORNL for 2009. Appendix A contains themore » agenda for the workshop; Appendix B lists the workshop attendees and presenters with contact information; Appendix C contains graphics of the evaluation form results and survey areas; and Appendix D summarizes the responses to the workshop evaluation form. The workshop was an opportunity for ORNL, Y-12, and SRNL staff with more than 30 years combined experience in nuclear nonproliferation to provide a comprehensive overview of their expertise for the university professors and their students. The overall goal of the workshop was to emphasize nonproliferation aspects of the nuclear fuel cycle and to identify specific areas where the universities and experts from operations and national laboratories could collaborate.« less

49 CFR 179.300-13 - Venting, loading and unloading valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-13 Venting... (h)(3)(ii). Threads for the clean-out/inspection ports of DOT Specification 110A multi-unit tank car...

Modular Hydropower Engineering and Pilot Scale Manufacturing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chesser, Phillip C.

Emrgy has developed, prototyped and tested a modular hydropower system for renewable energy generation. ORNL worked with Emrgy to demonstrate the use of additive manufacturing in the production of the hydrofoils and spokes for the hydrokinetic system. Specifically, during Phase 1 of this effort, ORNL printed and finished machined patterns for both the hydrofoils and spokes that were subsequently used in a sand casting manufacturing process. Emrgy utilized the sand castings for a pilot installation in Denver, CO, where the parts represented an 80% cost savings from the previous prototype build that was manufactured using subtractive manufacturing. In addition, themore » castings were completed with ORNL’s newly developed AlCeMg alloy that will be tested for performance improvements including higher corrosion resistance in a water application than the 6160 alloy used previously« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2011. The associated FY 2011 ORNL LDRD Self-Assessment (ORNL/PPA-2012/2) provides financial datamore » and an internal evaluation of the program’s management process.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The Laboratory Directed Research and Development (LDRD) program at Oak Ridge National Laboratory (ORNL) reports its status to the U.S. Department of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, “Laboratory Directed Research and Development” (April 19, 2006), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries of all ORNL LDRD research activities supported during FY 2010. The associated FY 2010 ORNL LDRD Self-Assessment (ORNL/PPA-2011/2) provides financial datamore » and an internal evaluation of the program’s management process.« less

BIOME: A scientific data archive search-and-order system using browser-aware, dynamic pages.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jennings, S.V.; Yow, T.G.; Ng, V.W.

1997-08-01

The Oak Ridge National Laboratory`s (ORNL) Distributed Active Archive Center (DAAC) is a data archive and distribution center for the National Air and Space Administration`s (NASA) Earth Observing System Data and Information System (EOSDIS). Both the Earth Observing System (EOS) and EOSDIS are components of NASA`s contribution to the US Global Change Research Program through its Mission to Planet Earth Program. The ORNL DAAC provides access to data used in ecological and environmental research such as global change, global warming, and terrestrial ecology. Because of its large and diverse data holdings, the challenge for the ORNL DAAC is to helpmore » users find data of interest from the hundreds of thousands of files available at the DAAC without overwhelming them. Therefore, the ORNL DAAC has developed the Biogeochemical Information Ordering Management Environment (BIOME), a customized search and order system for the World Wide Web (WWW). BIOME is a public system located at http://www-eosdis.ornl.gov/BIOME/biome.html.« less

BIOME: A scientific data archive search-and-order system using browser-aware, dynamic pages

NASA Technical Reports Server (NTRS)

Jennings, S. V.; Yow, T. G.; Ng, V. W.

1997-01-01

The Oak Ridge National Laboratory's (ORNL) Distributed Active Archive Center (DAAC) is a data archive and distribution center for the National Air and Space Administration's (NASA) Earth Observing System Data and Information System (EOSDIS). Both the Earth Observing System (EOS) and EOSDIS are components of NASA's contribution to the US Global Change Research Program through its Mission to Planet Earth Program. The ORNL DAAC provides access to data used in ecological and environmental research such as global change, global warming, and terrestrial ecology. Because of its large and diverse data holdings, the challenge for the ORNL DAAC is to help users find data of interest from the hundreds of thousands of files available at the DAAC without overwhelming them. Therefore, the ORNL DAAC has developed the Biogeochemical Information Ordering Management Environment (BIOME), a customized search and order system for the World Wide Web (WWW). BIOME is a public system located at http://www-eosdis. ornl.gov/BIOME/biome.html.

Agile based "Semi-"Automated Data ingest process : ORNL DAAC example

NASA Astrophysics Data System (ADS)

Santhana Vannan, S. K.; Beaty, T.; Cook, R. B.; Devarakonda, R.; Hook, L.; Wei, Y.; Wright, D.

2015-12-01

The ORNL DAAC archives and publishes data and information relevant to biogeochemical, ecological, and environmental processes. The data archived at the ORNL DAAC must be well formatted, self-descriptive, and documented, as well as referenced in a peer-reviewed publication. The ORNL DAAC ingest team curates diverse data sets from multiple data providers simultaneously. To streamline the ingest process, the data set submission process at the ORNL DAAC has been recently updated to use an agile process and a semi-automated workflow system has been developed to provide a consistent data provider experience and to create a uniform data product. The goals of semi-automated agile ingest process are to: 1.Provide the ability to track a data set from acceptance to publication 2. Automate steps that can be automated to improve efficiencies and reduce redundancy 3.Update legacy ingest infrastructure 4.Provide a centralized system to manage the various aspects of ingest. This talk will cover the agile methodology, workflow, and tools developed through this system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfiffner, Susan M.; Brandt, Craig C.; Kostka, Joel E.

Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), Florida State University (FSU), and the University of Tennessee. ORNL will serve as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project was initiated in November, 2004, in the Integrative Studies Element of the NABIR program. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates. The research seeks to address the following questions: Is the metabolic diversity of the in situ microbial community sufficiently largemore » and redundant that bioimmobilization of uranium will occur regardless of the type of electron donor added to the system? Are their donor specific effects that lead to enrichment of specific community members that then impose limits on the functional capabilities of the system? Will addition of humics change rates of uranium reduction without changing community structure? Can resource-ratio theory be used to understand changes in uranium reduction rates and community structure with respect to changing C:P ratios?« less

Trauma Pod/Operating Room of the Future

DTIC Science & Technology

2006-02-01

into C++ objects. OpenBinder software provided by ORNL was also used. This approach reduces the potential errors that might be introduced by...publications can be found here. OSCAR has been used by developers at the Univ. of Texas, ORNL , NASA/Ames, and NASA/JSC. RRGKinematix, a single...the last DH frame (at the wrist) is 70 mm. Position Travel Limits (degrees) - these are software limits as specified by ORNL Joint 1

Remote Systems Experience at the Oak Ridge National Laboratory--A Summary of Lessons Learned

DOE Office of Scientific and Technical Information (OSTI.GOV)

Noakes, Mark W; Burgess, Thomas W; Rowe, John C

2011-01-01

Oak Ridge National Laboratory (ORNL) has a long history in the development of remote systems to support the nuclear environment. ORNL, working in conjunction with Central Research Laboratories, created what is believed to be the first microcomputer-based implementation of dual-arm master-slave remote manipulation. As part of the Consolidated Fuel Reprocessing Program, ORNL developed the dual-arm advanced servomanipulator focusing on remote maintainability for systems exposed to high radiation fields. ORNL also participated in almost all of the various technical areas of the U.S. Department of Energy s Robotics Technology Development Program, while leading the Decontamination and Decommissioning and Tank Waste Retrievalmore » categories. Over the course of this involvement, ORNL has developed a substantial base of working knowledge as to what works when and under what circumstances for many types of remote systems tasks as well as operator interface modes, control bandwidth, and sensing requirements to name a few. By using a select list of manipulator systems that is not meant to be exhaustive, this paper will discuss history and outcome of development, field-testing, deployment, and operations from a lessons learned perspective. The final outcome is a summary paper outlining ORNL experiences and guidelines for transition of developmental remote systems to real-world hazardous environments.« less

Characterization and Activation Study of Black Chars Derived from Cellulosic Biomass Pyrolyzed at Very High Temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Contescu, Cristian I.; Gallego, Nidia C.

2017-03-01

The State of Tennessee, in partnership with the University of Tennessee (UT) and the Oak Ridge National Laboratory (ORNL), has created the RevV! Manufacturing voucher program to help Tennessee manufacturers gain access to the world-class resources at ORNL. As a part of this program, ORNL was working with Proton Power, Inc. (PPI), a rapidly growing company located in Lenoir City, Tennessee. PPI has developed a patented renewable energy system that uses biomass and waste sources to produce inexpensive hydrogen gas or synthetic fuels which are economically competitive with fossil fuels. The pyrolysis process used by PPI in their manufacturing chainmore » generates significant amounts of black carbon char as by-product. The scope of ORNL collaboration with PPI was assessing the black carbon char as a potential feedstock for activated carbon production, as this could be a potentially new revenue stream. During 2015-2016 ORNL received eight char samples from PPI and characterized their initial properties, simulated their physical activation by carbon dioxide, prepared gram-size samples of physically activated carbons, and characterized their surface and porosity properties. This report presents a summary of the work methods employed and the results obtained in the collaborative project between ORNL and PPI.« less

49 CFR 179.220 - General specifications applicable to nonpressure tank car tanks consisting of an inner container...

Code of Federal Regulations, 2012 CFR

2012-10-01

... tank car tanks consisting of an inner container supported within an outer shell (class DOT-115). 179... AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220...

Nonlinear Dot Plots.

PubMed

Rodrigues, Nils; Weiskopf, Daniel

2018-01-01

Conventional dot plots use a constant dot size and are typically applied to show the frequency distribution of small data sets. Unfortunately, they are not designed for a high dynamic range of frequencies. We address this problem by introducing nonlinear dot plots. Adopting the idea of nonlinear scaling from logarithmic bar charts, our plots allow for dots of varying size so that columns with a large number of samples are reduced in height. For the construction of these diagrams, we introduce an efficient two-way sweep algorithm that leads to a dense and symmetrical layout. We compensate aliasing artifacts at high dot densities by a specifically designed low-pass filtering method. Examples of nonlinear dot plots are compared to conventional dot plots as well as linear and logarithmic histograms. Finally, we include feedback from an expert review.

2002 Airborne Geophysical Survey at Pueblo of Isleta Bombing Targets, New Mexico, April 10 May 6, 2002 (Rev 1)

DTIC Science & Technology

2005-12-01

helicopter geophysical survey performed by US Army Engineering Support Center, Huntsville (USAESCH) and Oak Ridge National Laboratory ( ORNL ) over areas...Array Detection System NAD North American Datum ORAGS Oak Ridge Airborne Geophysical System ORNL Oak Ridge National Laboratory RMS Root...used by ORNL in 1999 for.....................5 Figure 2.4 ORAGS-Hammerhead airborne magnetometer system used at Badlands Bombing Range in FY2000

A Report Guide to Radiographic Testing Literature. Volume 6

DTIC Science & Technology

1975-04-01

Sources and Applications IITRI, Chicago, 111., 21-22 October 1964, ORNL -11C5, UC-23-Isotopes-Industrial Technology, November 1965 This...Applications IITRI, Chicago, IU., 21-22 October 1964. ORNL -11C5, UC-23lsotopes-lndustria3 Technology November 1965 The design of radioactive sources...Mich. Proceedings of Symposium on Low-Energy X and Gamma Sources and Applications IITRI, Chicago, HI., 21-22 October 1964. ORNL -11C5, US-23-Isotopes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klasson, K.T.; Abramowicz, D.A.

The Cooperative Research and Development Agreement was signed between Oak Ridge National Laboratory (ORNL) and General Electric Company (GE) on August 12, 1991. The objective was a collaborative venture between researchers at GE and ORNL to develop bioremediation of polychlorinated biphenyls (PCBs). The work was conducted over three years, and this report summarizes ORNL`s effort. It was found that the total concentration of PCBs decreased by 70% for sequential anaerobic-aerobic treatment compared with a 67% decrease for aerobic treatment alone. The sequential treatment resulted in PCB products with fewer chlorines and shorter halflives in humans compared with either anaerobic ormore » aerobic treatment alone. The study was expected to lead to a technology applicable to a field experiment that would be performed on a DOE contaminated site.« less

THE EXPERIMENTAL DESIGN FOR BeO IRAADIATION EXPERIMENTS ORNL 41-8 AND ORNL 41-9

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gardiner, D.A.

1962-07-18

The experimental plan for irradiating BeO pellets in Experiments ORNL 41- 8 and ORNL 41-9 was chosen in accordance with the principles of experimental design. The design is known by statisticians as a 2/sup 5/ factorial experiment confound'' in six replications. Five variables---size, density, grain size, temperature and time--are controlled at two levels to form the basic 2i factorial experiment. The sixth variable, neutron flux, is introduced by confounding on higher-order interactions. An explanation is presented in nontechnical language the means by which the aims of the experimenters and the physical conditions affecting the experiment were utilized in constructing themore » experimental design. (auth)« less

Laboratory Directed Research and Development Program FY 2006 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sjoreen, Terrence P

2007-04-01

The Oak Ridge National Laboratory (ORNL) Laboratory Directed Research and Development (LDRD) Program reports its status to the US Departmental of Energy (DOE) in March of each year. The program operates under the authority of DOE Order 413.2B, 'Laboratory Directed Research and Development' (April 19, 2006), which establishes DOE's requirements for the program while providing the Laboratory Director broad flexibility for program implementation. LDRD funds are obtained through a charge to all Laboratory programs. This report includes summaries all ORNL LDRD research activities supported during FY 2006. The associated FY 2006 ORNL LDRD Self-Assessment (ORNL/PPA-2007/2) provides financial data about themore » FY 2006 projects and an internal evaluation of the program's management process.« less

A tunable few electron triple quantum dot

NASA Astrophysics Data System (ADS)

Gaudreau, L.; Kam, A.; Granger, G.; Studenikin, S. A.; Zawadzki, P.; Sachrajda, A. S.

2009-11-01

In this paper, we report on a tunable few electron lateral triple quantum dot design. The quantum dot potentials are arranged in series. The device is aimed at studies of triple quantum dot properties where knowing the exact number of electrons is important as well as quantum information applications involving electron spin qubits. We demonstrate tuning strategies for achieving required resonant conditions such as quadruple points where all three quantum dots are on resonance. We find that in such a device resonant conditions at specific configurations are accompanied by complex charge transfer behavior.

49 CFR 179.300-8 - Tank heads.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-8 Tank heads. (a) Class DOT-110A tanks shall...

49 CFR 179.300-6 - Thickness of plates.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-6 Thickness of plates. (a) For class DOT...

49 CFR 179.300-8 - Tank heads.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-8 Tank heads. (a) Class DOT-110A tanks shall...

78 FR 15303 - Hazardous Materials; Miscellaneous Amendments (RRR)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-11

..., designated as sharps, in non-DOT specification containers fitted into wheeled racks. Revise the requirements... regulated medical wastes, designated as sharps, in non-DOT specification containers fitted into wheeled... Code Amendment 35-10, section 5.4.1.4.3.2 requires empty uncleaned packagings, IBCs, bulk containers...

Next Generation Waste Tracking: Linking Legacy Systems with Modern Networking Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walker, Randy M.; Resseguie, David R.; Shankar, Mallikarjun

2010-01-01

This report describes results from a preliminary analysis to satisfy the Department of Energy (DOE) objective to ensure the safe, secure, efficient packaging and transportation of materials both hazardous and non hazardous [1, 2]. The DOE Office of Environmental Management (OEM) through Oak Ridge National Laboratory (ORNL) has embarked on a project to further this objective. OEM and ORNL have agreed to develop, demonstrate and make available modern day cost effective technologies for characterization, identification, tracking, monitoring and disposal of radioactive waste when transported by, or between, motor, air, rail, and water modes. During the past 8 years ORNL hasmore » investigated and deployed Web 2.0 compliant sensors into the transportation segment of the supply chain. ORNL has recently demonstrated operational experience with DOE Oak Ridge Operations Office (ORO) and others in national test beds and applications within this domain of the supply chain. Furthermore, in addition to DOE, these hazardous materials supply chain partners included Federal and State enforcement agencies, international ports, and commercial sector shipping operations in a hazardous/radioactive materials tracking and monitoring program called IntelligentFreight. IntelligentFreight is an ORNL initiative encompassing 5 years of research effort associated with the supply chain. The ongoing ORNL SmartFreight programs include RadSTraM [3], GRadSTraM , Trusted Corridors, SensorPedia [4], SensorNet, Southeastern Transportation Corridor Pilot (SETCP) and Trade Data Exchange [5]. The integration of multiple technologies aimed at safer more secure conveyance has been investigated with the core research question being focused on testing distinctly different distributed supply chain information sharing systems. ORNL with support from ORO have demonstrated capabilities when transporting Environmental Management (EM) waste materials for disposal over an onsite haul road. ORNL has unified the operations of existing legacy hazardous, radioactive and related informational databases and systems using emerging Web 2.0 technologies. These capabilities were used to interoperate ORNL s waste generating, packaging, transportation and disposal with other DOE ORO waste management contractors. Importantly, the DOE EM objectives were accomplished in a cost effective manner without altering existing information systems. A path forward is to demonstrate and share these technologies with DOE EM, contractors and stakeholders. This approach will not alter existing DOE assets, i.e. Automated Traffic Management Systems (ATMS), Transportation Tracking and Communications System (TRANSCOM), the Argonne National Laboratory (ANL) demonstrated package tracking system, etc« less

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

NASA Astrophysics Data System (ADS)

Szuchmacher Blum, Amy; Soto, Carissa M.; Wilson, Charmaine D.; Whitley, Jessica L.; Moore, Martin H.; Sapsford, Kim E.; Lin, Tianwei; Chatterji, Anju; Johnson, John E.; Ratna, Banahalli R.

2006-10-01

Short, histidine-containing peptides can be conjugated to lysine-containing protein scaffolds to controllably attach quantum dots (QDs) to the scaffold, allowing for generic attachment of quantum dots to any protein without the use of specially engineered domains. This technique was used to bind quantum dots from aqueous solution to both chicken IgG and cowpea mosaic virus (CPMV), a 30 nm viral particle. These quantum dot protein assemblies were studied in detail. The IgG QD complexes were shown to retain binding specificity to their antigen after modification. The CPMV QD complexes have a local concentration of quantum dots greater than 3000 nmol ml-1, and show a 15% increase in fluorescence quantum yield over free quantum dots in solution.

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

PubMed Central

Jo, Stephanie Y.; Granowicz, Eric M.; Maillard, Ivan; Thomas, Dafydd

2011-01-01

Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with translocation partners of Mixed Lineage Leukemia (MLL) gene, which is commonly translocated in human leukemia. However, the requirement of Dot1l in postnatal hematopoiesis and leukemogenesis of MLL translocation proteins has not been conclusively shown. With a conditional Dot1l knockout mouse model, we examined the consequences of Dot1l loss in postnatal hematopoiesis and MLL translocation leukemia. Deletion of Dot1l led to pancytopenia and failure of hematopoietic homeostasis, and Dot1l-deficient cells minimally reconstituted recipient bone marrow in competitive transplantation experiments. In addition, MLL-AF9 cells required Dot1l for oncogenic transformation, whereas cells with other leukemic oncogenes, such as Hoxa9/Meis1 and E2A-HLF, did not. These findings illustrate a crucial role of Dot1l in normal hematopoiesis and leukemogenesis of specific oncogenes. PMID:21398221

49 CFR 179.300 - General specifications applicable to multi-unit tank car tanks designed to be removed from car...

Code of Federal Regulations, 2012 CFR

2012-10-01

... tank car tanks designed to be removed from car structure for filling and emptying (Classes DOT-106A and...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300...

49 CFR 179.300 - General specifications applicable to multi-unit tank car tanks designed to be removed from car...

Code of Federal Regulations, 2011 CFR

2011-10-01

... tank car tanks designed to be removed from car structure for filling and emptying (Classes DOT-106A and...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300...

Special Year on Numerical Linear Algebra

DTIC Science & Technology

1988-09-01

ORNL) Worley, Pat (ORNL) A special acknowledgement should go to Mary Drake (UT) and Mitzy Denson (ORNL) who carried the burden of making the innumerable...a time step appropriate for the regular cells with no stability restriction. Entrance to Y-12 requires a pass. Contact Mitzy Denson (615) 574-3125 to...requires a pass. Contact Mitzy Denson (615) 574-3125 to obtain one. ’This seminar is part of the Special Year on Numerical Linear Algebra sponsored by the

Adsorption Properties of Lignin-derived Activated Carbon Fibers (LACF)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Contescu, Cristian I.; Gallego, Nidia C.; Thibaud-Erkey, Catherine

The object of this CRADA project between Oak Ridge National Laboratory (ORNL) and United Technologies Research Center (UTRC) is the characterization of lignin-derived activated carbon fibers (LACF) and determination of their adsorption properties for volatile organic compounds (VOC). Carbon fibers from lignin raw materials were manufactured at Oak Ridge National Laboratory (ORNL) using the technology previously developed at ORNL. These fibers were physically activated at ORNL using various activation conditions, and their surface area and pore-size distribution were characterized by gas adsorption. Based on these properties, ORNL did down-select five differently activated LACF materials that were delivered to UTRC formore » measurement of VOC adsorption properties. UTRC used standard techniques based on breakthrough curves to measure and determine the adsorption properties of indoor air pollutants (IAP) - namely formaldehyde and carbon dioxide - and to verify the extent of saturated fiber regenerability by thermal treatments. The results are summarized as follows: (1) ORNL demonstrated that physical activation of lignin-derived carbon fibers can be tailored to obtain LACF with surface areas and pore size distributions matching the properties of activated carbon fibers obtained from more expensive, fossil-fuel precursors; (2) UTRC investigated the LACF potential for use in air cleaning applications currently pursued by UTRC, such as building ventilation, and demonstrated their regenerability for CO2 and formaldehyde, (3) Both partners agree that LACF have potential for possible use in air cleaning applications.« less

The Center for Nanophase Materials Sciences

NASA Astrophysics Data System (ADS)

Lowndes, Douglas

2005-03-01

The Center for Nanophase Materials Sciences (CNMS) located at Oak Ridge National Laboratory (ORNL) will be the first DOE Nanoscale Science Research Center to begin operation, with construction to be completed in April 2005 and initial operations in October 2005. The CNMS' scientific program has been developed through workshops with the national community, with the goal of creating a highly collaborative research environment to accelerate discovery and drive technological advances. Research at the CNMS is organized under seven Scientific Themes selected to address challenges to understanding and to exploit particular ORNL strengths (see http://cnms.ornl.govhttp://cnms.ornl.gov). These include extensive synthesis and characterization capabilities for soft, hard, nanostructured, magnetic and catalytic materials and their composites; neutron scattering at the Spallation Neutron Source and High Flux Isotope Reactor; computational nanoscience in the CNMS' Nanomaterials Theory Institute and utilizing facilities and expertise of the Center for Computational Sciences and the new Leadership Scientific Computing Facility at ORNL; a new CNMS Nanofabrication Research Laboratory; and a suite of unique and state-of-the-art instruments to be made reliably available to the national community for imaging, manipulation, and properties measurements on nanoscale materials in controlled environments. The new research facilities will be described together with the planned operation of the user research program, the latter illustrated by the current ``jump start'' user program that utilizes existing ORNL/CNMS facilities.

Nuisance Wildlife Education and Prevention Plan for the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Giffen, Neil R

This document outlines a plan for management of nuisance wildlife at the Oak Ridge National Laboratory (ORNL). Nuisance wildlife management includes wildlife population control through hunting, trapping, removal, and habitat manipulation; wildlife damage control; and law enforcement. This plan covers the following subjects: (1) roles and responsibilities of individuals, groups, and agencies; (2) the general protocol for reducing nuisance wildlife problems; and (3) species-specific methodologies for resolving nuisance wildlife management issues for mammals, birds, snakes, and insects. Achievement of the objectives of this plan will be a joint effort between the Tennessee Wildlife Resources Agency (TWRA); U. S. Department ofmore » Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS)-Wildlife Services (WS); and ORNL through agreements between TWRA and the U.S. Department of Energy (DOE); DOE and UT-Battelle, LLC; and UT-Battelle, LLC; and USDA, APHIS-WS.« less

ICRF Development for the Variable Specific Impulse Magnetoplasma Rocket

NASA Astrophysics Data System (ADS)

Ryan, P. M.; Baity, F. W.; Barber, G. C.; Carter, M. D.; Hoffman, D. J.; Jaeger, E. F.; Taylor, D. J.; Chang-Diaz, F. R.; Squire, J. P.; McCaskill, G.

1997-11-01

The feasibility of using magnetically vectored and rf-heated plasmas for space propulsion (F. R. Chang-Diaz, et al., Bull. Am. Phys. Soc., 41, 1541 (1996)) is being investigated experimentally on an asymmetric magnetic mirror device at the Advanced Space Propulsion Laboratory (ASPL), Johnson Space Center, NASA. Analysis of the antenna interaction with and the wave propagation through the dense plasma propulsion system is being studied at ORNL(Oak Ridge National Laboratory, managed by Lockheed Martin Energy Research Corp. for the U.S. Department of Energy under contract number DE-AC05-96OR22464.), using antenna design codes developed for ICH systems and mirror codes developed for the EBT experiment at ORNL. The present modeling effort is directed toward the ASPL experimental device. Antenna optimization and performance, as well as the design considerations for space-qualified rf components and systems (minimizing weight while maximizing reliability) will be presented.

Bioenergy Feedstock Development Program Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kszos, L.A.

2001-02-09

The U.S. Department of Energy's (DOE's) Bioenergy Feedstock Development Program (BFDP) at Oak Ridge National Laboratory (ORNL) is a mission-oriented program of research and analysis whose goal is to develop and demonstrate cropping systems for producing large quantities of low-cost, high-quality biomass feedstocks for use as liquid biofuels, biomass electric power, and/or bioproducts. The program specifically supports the missions and goals of DOE's Office of Fuels Development and DOE's Office of Power Technologies. ORNL has provided technical leadership and field management for the BFDP since DOE began energy crop research in 1978. The major components of the BFDP include energymore » crop selection and breeding; crop management research; environmental assessment and monitoring; crop production and supply logistics operational research; integrated resource analysis and assessment; and communications and outreach. Research into feedstock supply logistics has recently been added and will become an integral component of the program.« less

Preliminary Report on Oak Ridge National Laboratory Testing of Drake/ACSS/MA2/E3X

DOE Office of Scientific and Technical Information (OSTI.GOV)

Irminger, Philip; King, Daniel J.; Herron, Andrew N.

2016-01-01

A key to industry acceptance of a new technology is extensive validation in field trials. The Powerline Conductor Accelerated Test facility (PCAT) at Oak Ridge National Laboratory (ORNL) is specifically designed to evaluate the performance and reliability of a new conductor technology under real world conditions. The facility is set up to capture large amounts of data during testing. General Cable used the ORNL PCAT facility to validate the performance of TransPowr with E3X Technology a standard overhead conductor with an inorganic high emissivity, low absorptivity surface coating. Extensive testing has demonstrated a significant improvement in conductor performance across amore » wide range of operating temperatures, indicating that E3X Technology can provide a reduction in temperature, a reduction in sag, and an increase in ampacity when applied to the surface of any overhead conductor. This report provides initial results of that testing.« less

Neutrons Provide the First Nanoscale Look at a Living Cell Membrane

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Neutron scattering is a valuable technique for studying cell membranes, but signals from the cell’s other components such as proteins, RNA, DNA and carbohydrates can get in the way. An ORNL team made these other components practically invisible to neutrons by combining specific levels of heavy hydrogen (deuterium) with normal hydrogen within the cell.

49 CFR 179.220 - General specifications applicable to nonpressure tank car tanks consisting of an inner container...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false General specifications applicable to nonpressure tank car tanks consisting of an inner container supported within an outer shell (class DOT-115). 179... within an outer shell (class DOT-115). ...

49 CFR 179.220 - General specifications applicable to nonpressure tank car tanks consisting of an inner container...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false General specifications applicable to nonpressure tank car tanks consisting of an inner container supported within an outer shell (class DOT-115). 179... within an outer shell (class DOT-115). ...

78 FR 16044 - Hazardous Materials Packaging-Composite Cylinder Standards; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-13

.... PHMSA-2013-0017; Notice No. 13-02] Hazardous Materials Packaging--Composite Cylinder Standards; Public..., marking, sale and use of non-DOT specification composite cylinders. The non-DOT specification cylinders... Organization (ISO) standards for composite cylinders ISO 11119 Parts - 1, -2, -3 incorporated by reference into...

Contribution of dot-blot assay to the diagnosis and management of myositis: a three-year practice at a university hospital centre.

PubMed

Martel, Clothilde; Vignaud, Guillaume; Liozon, Eric; Magy, Laurent; Gallouedec, Gael; Ly, Kim; Bezanahary, Holly; Cypierre, Anne; Lapébie, François-Xavier; Palat, Sylvain; Gondran, Guillaume; Jauberteau, Marie-Odile; Fauchais, Anne-Laure

2016-01-01

Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases with wide clinical spectrum that may lead to delayed diagnosis. The aim of this study was to examine the impact of IIM-specific dot-blot assay on diagnostic process of patients presenting with muscular or systemic symptoms evocating of IIM. We collected all the prescriptions of an IIM specific dot-blot assay (8 autoantigens including Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, PM/Scl and Scl-70) over a 38-month period. 316 myositis dot-blot assays (MSD) were performed in 274 patients (156 women, mean age 53±10.6 years) referring for muscular and/or systemic symptoms suggesting IIM. The timing of dot prescription through the diagnostic process was highly variable: without (35%), concomitantly (16%) or after electromyographic studies (35%). Fifty-nine patients (22%) had IIM according to Bohan and Peter's criteria. Among them, 29 (49%) had positive dot (8 Jo-1, 6 PM-Scl, 5 PL-12, 5 SRP, 2 Mi-2, 2 PL-7 and 1 Ku). Various other diagnoses were performed including 35 autoimmune disease or granulomatosis (12%), 19 inflammatory rheumatic disease (7%), 16 non inflammatory muscular disorders (6%), 10 drug-induced myalgia (4%), 11 infectious myositis (4%). Except 11 borderline SRP results and one transient PM-Scl, MSD was positive only in one case of IIM. Dot allowed clinicians to correct diagnosis in 4 cases and improved the diagnosis of IIM subtypes in 4 cases. This study reflects the interest of myositis dot in the rapid diagnosis process of patients with non-specific muscular symptoms leading to various diagnoses including IIM.

Roderick Jackson | NREL

Science.gov Websites

Laboratory (ORNL), where he was the group manager for Building Envelope Systems Research. One of Jackson's Manufacturing Integrated Energy (AMIE) demonstration project at ORNL. With Jackson's leadership, AMIE brought

Procedures manual for the ORNL Radiological Survey Activities (RASA) Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myrick, T.E.; Berven, B.A.; Cottrell, W.D.

The portion of the radiological survey program performed by ORNL is the subject of this Procedures Manual. The RASA group of the Health and Safety Research Division (HASRD) at ORNL is responsible for the planning, conducting, and reporting of the results of radiological surveys at specified sites and associated vicinity properties. The results of these surveys are used by DOE in determining the need for and extent of remedial actions. Upon completion of the necessary remedial actions, the ORNL-RASA group or other OOS contractor may be called upon to verify the effectiveness of the remedial action. Information from these postremedialmore » action surveys is included as part of the data base used by DOE in certifying a site for unrestricted use.« less

Hierarchical colorant-based direct binary search halftoning.

PubMed

He, Zhen

2010-07-01

Colorant-based direct binary search (CB-DBS) halftoning proposed in provides an image quality benchmark for dispersed-dot halftoning algorithms. The objective of this paper is to further push the image quality limit. An algorithm called hierarchical colorant-based direct binary search (HCB-DBS) is developed in this paper. By appropriately integrating yellow colorant into dot-overlapping and dot-positioning controls, it is demonstrated that HCB-DBS can achieve better halftone texture of both individual and joint dot-color planes, without compromising the dot distribution of more visible halftone of cyan and magenta colorants. The input color specification is first converted from colorant space to dot-color space with minimum brightness variation principle for full dot-overlapping control. The dot-colors are then split into groups based upon dot visibility. Hierarchical monochrome DBS halftoning is applied to make dot-positioning decision for each group, constrained on the already generated halftone of the groups with higher priority. And dot-coloring is decided recursively with joint monochrome DBS halftoning constrained on the related total dot distribution. Experiments show HCB-DBS improves halftone texture for both individual and joint dot-color planes. And it reduces the halftone graininess and free of color mottle artifacts, comparing to CB-DBS.

Detection of toxoplasma-specific immunoglobulin G in human sera: performance comparison of in house Dot-ELISA with ECLIA and ELISA.

PubMed

Teimouri, Aref; Modarressi, Mohammad Hossein; Shojaee, Saeedeh; Mohebali, Mehdi; Zouei, Nima; Rezaian, Mostafa; Keshavarz, Hossein

2018-05-08

In the current study, performance of electrochemiluminescence immunoassay (ECLIA) in detection of anti-toxoplasma IgG in human sera was compared with that of enzyme-linked immunosorbent assay (ELISA). Furthermore, performance of an in house Dot-ELISA in detection of anti-toxoplasma IgG was compared with that of ECLIA and ELISA. In total, 219 human sera were tested to detect anti-toxoplasma IgG using Dynex DS2® and Roche Cobas® e411 Automated Analyzers. Discordant results rechecked using immunofluorescence assay (IFA). Then, sera were used in an in house Dot-ELISA to assess toxoplasma-specific IgG. Of the 219 samples, two samples were found undetermined using ECLIA but reactive using ELISA. Using IFA, the two sera were reported unreactive. Furthermore, two samples were found reactive using ECLIA and unreactive using ELISA. These samples were reported reactive using IFA. The overall agreement for the two former methods was 98% (rZ0.98.1; P < 0.001). The intrinsic parameters calculated for in house Dot-ELISA included sensitivity of 79.5, specificity of 78.2, and accuracy of 78.9%, compared to ECLIA and ELISA. Positive and negative predictive values included 82.9 and 74.2%, respectively. A 100% sensitivity was found in in house Dot-ELISA for highly reactive sera in ECLIA and ELISA. ECLIA is appropriate for the first-line serological screening tests and can replace ELISA due to high speed, sensitivity, and specificity, particularly in large laboratories. Dot-ELISA is a rapid, sensitive, specific, cost-effective, user-friendly, and field-portable technique and hence can be used for screening toxoplasmosis, especially in rural fields or less equipped laboratories.

49 CFR 178.345-1 - General requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Containers for Motor Vehicle Transportation § 178.345-1 General requirements. (a) Specification DOT 406, DOT 407 and DOT 412 cargo tank motor vehicles must conform to the requirements of this section in addition... definitions apply to §§ 178.345, 178.346, 178.347, and 178.348: Appurtenance means any cargo tank accessory...

49 CFR 178.345-1 - General requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Containers for Motor Vehicle Transportation § 178.345-1 General requirements. (a) Specification DOT 406, DOT 407 and DOT 412 cargo tank motor vehicles must conform to the requirements of this section in addition... definitions apply to §§ 178.345, 178.346, 178.347, and 178.348: Appurtenance means any cargo tank accessory...

49 CFR 178.345-1 - General requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Containers for Motor Vehicle Transportation § 178.345-1 General requirements. (a) Specification DOT 406, DOT 407 and DOT 412 cargo tank motor vehicles must conform to the requirements of this section in addition... definitions apply to §§ 178.345, 178.346, 178.347, and 178.348: Appurtenance means any cargo tank accessory...

DNA nanosensor based on biocompatible graphene quantum dots and carbon nanotubes.

PubMed

Qian, Zhao Sheng; Shan, Xiao Yue; Chai, Lu Jing; Ma, Juan Juan; Chen, Jian Rong; Feng, Hui

2014-10-15

An ultrasensitive nanosensor based on fluorescence resonance energy transfer (FRET) between biocompatible graphene quantum dots and carbon nanotubes for DNA detection was reported. We take advantage of good biocompatibility and strong fluorescence of graphene quantum dots, base pairing specificity of DNA and unique fluorescence resonance energy transfer between graphene quantum dots and carbon nanotubes to achieve the analysis of low concentrations of DNA. Graphene quantum dots with high quantum yield up to 0.20 were prepared and served as the fluorophore of DNA probe. FRET process between graphene quantum dots-labeled probe and oxidized carbon nanotubes is easily achieved due to their efficient self-assembly through specific π-π interaction. This nanosensor can distinguish complementary and mismatched nucleic acid sequences with high sensitivity and good reproducibility. The detection method based on this nanosensor possesses a broad linear span of up to 133.0 nM and ultralow detection limit of 0.4 nM. The constructed nanosensor is expected to be highly biocompatible because of all its components with excellent biocompatibility. Copyright © 2014 Elsevier B.V. All rights reserved.

Technical basis for nuclear accident dosimetry at the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerr, G.D.; Mei, G.T.

The Oak Ridge National Laboratory (ORNL) Environmental, Safety, and Health Emergency Response Organization has the responsibility of providing analyses of personnel exposures to neutrons and gamma rays from a nuclear accident. This report presents the technical and philosophical basis for the dose assessment aspects of the nuclear accident dosimetry (NAD) system at ORNL. The issues addressed are regulatory guidelines, ORNL NAD system components and performance, and the interpretation of dosimetric information that would be gathered following a nuclear accident.

Development and Evaluation of an Uncoupled, Incremental Constitutive Model for Elastic-Plastic-Creep Behavior at Elevated Temperatures.

DTIC Science & Technology

1982-05-01

Pugh, C. E., "Creep Studies on Type 304 Stainless Steel (Heat 8043813) Under Constant and Varying Loads," ORNL -TM- 4427 , June 1974, Oak Ridge National...34 hysteria loop predictions show. Oak Ridge ( ORNL ) [30) and combined hardening rules predict overall * 21 Stes Stress...Analysis of FFTF Components," ORNL TM-3602, Oak Ridge National Laboratory, Oak Ridge, Tenn., Sept. 1972. 31. Dafalias, Y. F., and Popov, E. P., "Plastic

Tier One: Draft Environmental Impact Statement. Volume 2. Realignment of Mountain Home Air Force Base and Proposed Expanded Range Capability

DTIC Science & Technology

1990-02-01

in section S3.1, Airspace Management. oue ORNL 1988 data. S3.10-2 S3.10.4 Community Services Community services provided at the county level include...Under the Base Realignment Project. Mountain Home City Clerk’s Office. 1989. Proposed Fiscal 1990 Budget. Oak Ridge National Laboratory ( ORNL ). 1988. Low...Altitude Airspace Database. Submitted to the U.S. Air Force. ORNL and Consultants. 1988. Reviews of Scientific Literatures on the Environmental

Ice-On-Coil Diurnal Ice Storage Cooling System for a Barracks/Office/ Dining Hall Facility at Yuma Proving Ground, AZ

DTIC Science & Technology

1990-09-01

Kedl is associated with the Oak Ridge National Laboratory ( ORNL ). The technical editor was Gloria J. Wienke, Information Management Office, USACERL. COL...of a DIS cooling system for Building 506, a barracks/ office/dining facility. Oak Ridge National Laboratory ( ORNL ) designed the system in cooperation... ORNL with assistance from YPG and analyzed by USACERL. R.J. Kedl and C.W. Sohn, As.vsment of Energy Storage Technologies for Army Facilities, Technical

Biocompatible Quantum Dots for Biological Applications

PubMed Central

Rosenthal, Sandra J.; Chang, Jerry C.; Kovtun, Oleg; McBride, James R.; Tomlinson, Ian D.

2011-01-01

Semiconductor quantum dots are quickly becoming a critical diagnostic tool for discerning cellular function at the molecular level. Their high brightness, long-lasting, sizetunable, and narrow luminescence set them apart from conventional fluorescence dyes. Quantum dots are being developed for a variety of biologically oriented applications, including fluorescent assays for drug discovery, disease detection, single protein tracking, and intracellular reporting. This review introduces the science behind quantum dots and describes how they are made biologically compatible. Several applications are also included, illustrating strategies toward target specificity, and are followed by a discussion on the limitations of quantum dot approaches. The article is concluded with a look at the future direction of quantum dots. PMID:21276935

Development of Implicit Compact Methods for Chemically Reacting Flows

DTIC Science & Technology

2009-02-28

NSP_P), DKt (NSP_P), & ! stoichiometric coeffs (# mols produced/destroyed) & NUK(NSP_P), & ! mass coeffs: NUK(k)*WK(k) & NUKWK(NSP_P), & & WK... DKt UC UCr wc WCz NUK NUKWK ! (nu_0 sstoich Yfuel Yox Yfuel_F Yox_A Z PHI omega SOURCE q HEAT = SpecificHeat(T) = 0 .do...RHO*T) dot_product(DK,YKr) ! correction vel. for mass conservation dot_product(DK,YKrr)+dot_product(( DKt *Tr),YKr) dot_product(DK,YKz) ! correction

Daymet: Daily Surface Weather Data on a 1-km Grid for North America, Version 2.

NASA Astrophysics Data System (ADS)

Devarakonda, R.

2014-12-01

Daymet: Daily Surface Weather Data and Climatological Summaries provides gridded estimates of daily weather parameters for North America, including daily continuous surfaces of minimum and maximum temperature, precipitation occurrence and amount, humidity, shortwave radiation, snow water equivalent, and day length. The current data product (Version 2) covers the period January 1, 1980 to December 31, 2013 [1]. Data are available on a daily time step at a 1-km x 1-km spatial resolution in Lambert Conformal Conic projection with a spatial extent that covers the North America as meteorological station density allows. Daymet data can be downloaded from 1) the ORNL Distributed Active Archive Center (DAAC) search and order tools (http://daac.ornl.gov/cgi-bin/cart/add2cart.pl?add=1219) or directly from the DAAC FTP site (http://daac.ornl.gov/cgi-bin/dsviewer.pl?ds_id=1219) and 2) the Single Pixel Tool (http://daymet.ornl.gov/singlepixel.html) and THREDDS (Thematic Real-time Environmental Data Services) Data Server (TDS) (http://daymet.ornl.gov/thredds_mosaics.html). The Single Pixel Data Extraction Tool [2] allows users to enter a single geographic point by latitude and longitude in decimal degrees. A routine is executed that translates the (lon, lat) coordinates into projected Daymet (x,y) coordinates. These coordinates are used to access the Daymet database of daily-interpolated surface weather variables. The Single Pixel Data Extraction Tool also provides the option to download multiple coordinates programmatically. The ORNL DAAC's TDS provides customized visualization and access to Daymet time series of North American mosaics. Users can subset and download Daymet data via a variety of community standards, including OPeNDAP, NetCDF Subset service, and Open Geospatial Consortium (OGC) Web Map/Coverage Service. References: [1] Thornton, P. E., Thornton, M. M., Mayer, B. W., Wilhelmi, N., Wei, Y., Devarakonda, R., & Cook, R. (2012). "Daymet: Daily surface weather on a 1 km grid for North America, 1980-2008". Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center for Biogeochemical Dynamics (DAAC), 1. [2] Devarakonda R., et al. 2012. Daymet: Single Pixel Data Extraction Tool. Available [http://daymet.ornl.go/singlepixel.html].

[Imaging of surface cell antigens on the tumor sections of lymph nodes using fluorescence quantum dots].

PubMed

Rafalovskaia-Orlovskaia, E P; Gorgidze, L A; Gladkikh, A A; Tauger, S M; Vorob'ev, I A

2012-01-01

The usefulness of quantum dots for the immunofluorescent detection of surface antigens on the lymphoid cells has been studied. To optimize quantum dots detection we have upgraded fluorescent microscope that allows obtaining multiple images from different quantum dots from one section. Specimens stained with quantum dots remained stable over two weeks and practically did not bleach under mercury lamp illumination during tens of minutes. Direct conjugates of primary mouse monoclonal antibodies with quantum dots demonstrated high specificity and sufficient sensitivity in the case of double staining on the frozen sections. Because of the high stability of quantum dots' fluorescence, this method allows to analyze antigen coexpression on the lymphoid tissue sections for diagnostic purposes. The spillover of fluorescent signals from quantum dots into adjacent fluorescent channels, with maxima differing by 40 nm, did not exceed 8%, which makes the spectral compensation is practically unnecessary.

ULTRACOATINGS: Enabling Energy and Power Solutions in High Contact Stress Environments through Next-Generation Nanocoatings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blau, P.; Qu, J.; Higdon, C. III

This industry-driven project was the result of a successful response by Eaton Corporation to a DOE/ITP Program, Grand Challenge, industry call. It consisted of a one-year effort in which ORNL participated in the area of friction and wear testing. In addition to Eaton Corporation and ORNL (CRADA), the project team included: Ames Laboratory, who developed the underlying concept for titanium- zirconium-boron (TZB) based nanocomposite coatings; Borg-Warner Morse TEC, an automotive engine timing chain manufacturer in Ithaca, New York, with its own proprietary hard coating; and Pratt & Whitney Rocketdyne, Inc., a dry-solids pump manufacturer in San Fernando Valley, California. Thismore » report focuses only on the portion of work that was conducted by ORNL, in a CRADA with Eaton Corporation. A comprehensive final report for the entire effort, which ended in September 2010, has been prepared for DOE by the team. The term 'ultracoatings' derives from the ambitious technical target for the new generation of nanocoatings. As applications, Eaton was specifically considering a fuel pump and a gear application in which the product of the contact pressure and slip velocity during operation of mating surfaces, commonly called the 'PV value', was equal to or greater than 70,000 MPa-m/s. This ambitious target challenges the developers of coatings to produce material capable of strong bonding to the substrate, as well as high wear resistance and the ability to maintain sliding friction at low, energy-saving levels. The partners in this effort were responsible for the selection and preparation of such candidate ultracoatings, and ORNL used established tribology testing capabilities to help screen these candidates for performance. This final report summarizes ORNL's portion of the nanocomposite coatings development effort and presents both generated data and the analyses that were used in the course of this effort. Initial contact stress and speed calculations showed that laboratory tests with available geometries, applied forces, and speeds at ORNL could not reach 70,000 MPa-m/s for the project target, so test conditions were modified to enable screening of the new coating compositions under conditions used in a prior nano-coatings development project with Eaton Corporation and Ames Laboratory. Eaton Innovation Center was able to conduct screening tests at higher loads and speeds, thus providing complementary information on coating durability and friction reduction. Those results are presented in the full team's final report which is in preparation at this writing. Tests of two types were performed at ORNL during the course of this work: (1) simulations of timing chain wear and friction under reciprocating conditions, and (2) pin-on-disk screening tests for bearings undergoing unidirectional sliding. The four materials supplied for evaluation in a timing chain link simulation were hardened type 440B stainless steel, nitrided type 440B stainless steel, vanadium carbide (VC)-coated type 52100 bearing steel, and (ZrTi)B-coated type 52100 bearing steel. Reciprocating wear tests revealed that the VC coating was by far the most wear resistant. In friction, the nitrided stainless steel did slightly better than the other materials.« less

76 FR 5483 - Hazardous Materials: Incorporation of Certain Cargo Tank Special Permits Into Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... material in a manner that varies from the regulations provided an equivalent level of safety is maintained... Permit (SP) 11209--Authorization to transport liquefied petroleum gas (LPG) in non-DOT specification... roadway striping in non-DOT specification cargo tanks. SP 13341--Authorization for private motor carriers...

49 CFR 178.3 - Marking of packagings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... packagings. (a) Each packaging represented as manufactured to a DOT specification or a UN standard must be... identifying the standards or specification (e.g. UN 1A1, DOT 4B240ET, etc.). (2) Unless otherwise specified in... authorized, the symbol of the approval agency certifying compliance with a UN standard. Symbols, if used...

49 CFR 178.3 - Marking of packagings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... packagings. (a) Each packaging represented as manufactured to a DOT specification or a UN standard must be... identifying the standards or specification (e.g. UN 1A1, DOT 4B240ET, etc.). (2) Unless otherwise specified in... compliance with a UN standard. Symbols, if used, must be registered with the Associate Administrator. Unless...

49 CFR 178.3 - Marking of packagings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... packagings. (a) Each packaging represented as manufactured to a DOT specification or a UN standard must be... identifying the standards or specification (e.g. UN 1A1, DOT 4B240ET, etc.). (2) Unless otherwise specified in... authorized, the symbol of the approval agency certifying compliance with a UN standard. Symbols, if used...

49 CFR 178.3 - Marking of packagings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... packagings. (a) Each packaging represented as manufactured to a DOT specification or a UN standard must be... identifying the standards or specification (e.g. UN 1A1, DOT 4B240ET, etc.). (2) Unless otherwise specified in... compliance with a UN standard. Symbols, if used, must be registered with the Associate Administrator. Unless...

Simple Identification of Human Taenia Species by Multiplex Loop-Mediated Isothermal Amplification in Combination with Dot Enzyme-Linked Immunosorbent Assay

PubMed Central

Nkouawa, Agathe; Sako, Yasuhito; Okamoto, Munehiro; Ito, Akira

2016-01-01

For differential detection of Taenia solium, Taenia saginata, and Taenia asiatica, loop-mediated isothermal amplification (LAMP) assay targeting the cytochrome c oxidase subunit 1 gene has been recently developed and shown to be sensitive, specific, and effective. However, to achieve differential identification, one specimen requires three reaction mixtures containing a primer set of each Taenia species separately, which is complex and time consuming and increases the risk of cross-contamination. In this study, we developed a simple differential identification of human Taenia species using multiplex LAMP (mLAMP) in combination with dot enzyme-linked immunosorbent assay (dot-ELISA). Forward inner primers of T. solium, T. saginata, and T. asiatica labeled with fluorescein isothiocyanate (FITC), digoxigenin (DIG), and tetramethylrhodamine (TAMRA), respectively, and biotin-labeled backward inner primers were used in mLAMP. The mLAMP assay succeeded in specific amplification of each respective target gene in a single tube. Furthermore, the mLAMP product from each species was easily distinguished by dot-ELISA with an antibody specific for FITC, DIG, or TAMRA. The mLAMP assay in combination with dot-ELISA will make identification of human Taenia species simpler, easier, and more practical. PMID:27044566

49 CFR 7.27 - What are the designated DOT FOIA Requester Service Centers?

Code of Federal Regulations, 2014 CFR

2014-10-01

... numbers identified at http://www.dot.gov/foia or the mailing addresses indicated below (unless a more up-to-date mailing address has been designated at http://www.dot.gov/foia): (1) FOIA Requester Service... Highway Administration, Room E64-302 (unless a more specific address has been designated by FHWA at http...

Quantum dot nanoparticle conjugation, characterization, and applications in neuroscience

NASA Astrophysics Data System (ADS)

Pathak, Smita

Quantum dot are semiconducting nanoparticles that have been used for decades in a variety of applications such as solar cells, LEDs and medical imaging. Their use in the last area, however, has been extremely limited despite their potential as revolutionary new biological labeling tools. Quantum dots are much brighter and more stable than conventional fluorophores, making them optimal for high resolution imaging and long term studies. Prior work in this area involves synthesizing and chemically conjugating quantum dots to molecules of interest in-house. However this method is both time consuming and prone to human error. Additionally, non-specific binding and nanoparticle aggregation currently prevent researchers from utilizing this system to its fullest capacity. Another critical issue that has not been addressed is determining the number of ligands bound to nanoparticles, which is crucial for proper interpretation of results. In this work, methods to label fixed cells using two types of chemically modified quantum dots are studied. Reproducible non-specific artifact labeling is consistently demonstrated if antibody-quantum dot conditions are less than optimal. In order to explain this, antibodies bound to quantum dots were characterized and quantified. While other groups have qualitatively characterized antibody functionalized quantum dots using TEM, AFM, UV spectroscopy and gel electrophoresis, and in some cases have reported calculated estimates of the putative number of total antibodies bound to quantum dots, no quantitative experimental results had been reported prior to this work. The chemical functionalization and characterization of quantum dot nanocrystals achieved in this work elucidates binding mechanisms of ligands to nanoparticles and allows researchers to not only translate our tools to studies in their own areas of interest but also derive quantitative results from these studies. This research brings ease of use and increased reliability to nanoparticles in medical imaging.

Site Sustainability Plan with FY2015 Performance Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nichols, Teresa A.; Lapsa, Melissa Voss; Hudey, Bryce D.

Oak Ridge National Laboratory (ORNL) is both the largest science and energy laboratory in the US Department of Energy (DOE) complex and one of the oldest national laboratories still operating at its original site. ORNL implemented an aggressive modernization program in 2000, providing modern, energy-efficient facilities that help to support the growth of important national scientific missions while faced with the unique and challenging opportunity to integrate sustainability into legacy assets. ORNL is committed to leveraging the outcomes of DOE-sponsored research programs to maximize the efficient use of energy and natural resources across a diverse campus. ORNL leadership in conjunctionmore » with the Sustainable Campus Initiative (SCI) maintains a commitment to the integration of technical innovations into new and existing facilities, systems, and processes with a comprehensive approach to achieving DOE directives and the new Executive Order 13693. Energy efficiency, greenhouse gas reductions, climate change resiliency, and other pursuits toward integrated sustainability factor in all we do. ORNL continues to pursue and deploy innovative solutions and initiatives to advance regional, national, and worldwide sustainability and continues to transform its culture and engage employees in supporting sustainability at work, at home, and in the community.« less

ORNL engineering design and construction reengineering report

DOE Office of Scientific and Technical Information (OSTI.GOV)

McNeese, L.E.

1998-01-01

A team composed of individuals representing research and development (R and D) divisions, infrastructure support organizations, and Department of Energy (DOE)-Oak Ridge Operations was chartered to reengineer the engineering, design, and construction (ED and C) process at Oak Ridge National Laboratory (ORNL). The team recognized that ED and C needs of both R and D customers and the ORNL infrastructure program have to be met to maintain a viable and competitive national laboratory. Their goal was to identify and recommend implementable best-in-class ED and C processes that will efficiently and cost-effectively support the ORNL R and D staff by beingmore » responsive to their programmatic and infrastructure needs. The team conducted process mapping of current and potential ED and C approaches, developed idealized versions of ED and C processes, and identified potential barriers to an efficient ED and C process. Eight subteams were assigned to gather information and to evaluate the significance of potential barriers through benchmarking, surveys, interviews, and reviews of key topical areas in order to determine whether the perceived barriers were real and important and whether they resulted from laws or regulations over which ORNL has no control.« less

Additive Manufacturing of Parts and Tooling in Robotic Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Love, Lonnie J.; Hassen, Ahmed A.; Chesser, Phillip C.

ORNL worked with Transcend Robotics, LLC to explore additive manufacturing of the two-piece compression body for their ARTI mobile robot platform. Extrusion compression molding was identified as an effective means of manufacturing these parts. ORNL consulted on modifications to the housing design to accommodate the selected manufacturing process. Parts were printed using ORNL's FDM machines for testing and evaluation of the design as a precursor to molding the parts. The assembly and evaluation of the parts proved favorable and minor design changes to improve assembly and performance were identified.The goal is to develop a light weight and rugged two-part roboticmore » enclosure for an unmanned ground vehicle UGV) that will be used in search and rescue applications. The FDM parts fabricated by ORNL allowed Transcend Robotics to assemble a prototype robot and verify that the new parts will meet the performance requirements. ORNL fabricated enclosure parts out of ABS and Nylon 12 materials such that the design could be tested prior to fabricating tooling for compression molding of Nylon 6 with carbon fiber fill. The robot was performance tested and compared with the previous manufacturing techniques and found to have superior performance.« less

R-X Modeling Figures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goda, Joetta Marie; Miller, Thomas; Grogan, Brandon

2016-10-26

This document contains figures that will be included in an ORNL final report that details computational efforts to model an irradiation experiment performed on the Godiva IV critical assembly. This experiment was a collaboration between LANL and ORNL.

Dr. Martin Keller - Laboratory Director | NREL

Science.gov Websites

, LLC. Keller has joined NREL from Oak Ridge National Laboratory (ORNL) where he served as the Associate and electronics systems. In 2006, Keller was recruited to ORNL from an industrial enzyme discovery and

NREL: News - Director of National Bioenergy Center Named

Science.gov Websites

coordinating NREL's activities with bioenergy research at Oak Ridge National Laboratory (ORNL) and other organizations. Pacheco will represent the NBC, NREL, ORNL, DOE, and the interests of bioenergy programs to

Waste certification program plan for Oak Ridge National Laboratory. Revision 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1997-09-01

This document defines the waste certification program (WCP) developed for implementation at Oak Ridge National Laboratory (ORNL). The document describes the program structure, logic, and methodology for certification of ORNL wastes. The purpose of the WCP is to provide assurance that wastes are properly characterized and that the Waste Acceptance Criteria (WAC) for receiving facilities are met. The program meets the waste certification requirements for mixed (both radioactive and hazardous) and hazardous [including polychlorinated biphenyls (PCB)] waste. Program activities will be conducted according to ORNL Level 1 document requirements.

A Preliminary Study of Reducing the Cost of Blast Shelter for Critical Workers

DTIC Science & Technology

1983-08-01

ArD-A2’ 3 •’ ORNL -5953 UNIONA Preliminary Study CARBJCEof Reducing the Cost of Blast Shelter for Critical Workers C. V. Chester D. W. Holladay ~s...DOCUMENTATION PAGE READ INSTRUCTIONS BEFORE COMPLETING FORM Ŗ. REPORT NUMBER 2. GOVT ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER ORNL (5958 .).4 ’I L...WORKERS 6. PERFORMING ORG. REPORT NUMBER ORNL /n5958 7. AUTHOR(a) 8. CONTRACT OR GRANT NUMBER(e) C. V. CHESTER, D. W. HOLLADAY FEMA EMW E 0.739 9

Projections of Demand for Waterborne Transportation, Ohio River Basin, 1980, 1990, 2000, 2020, 2040. Volume 4. Group II. Petroleum Fuels.

DTIC Science & Technology

1980-12-01

for1980 and 1985 (OaK Ridge, TN: ORNL , 1978), Table 1. I -11- B-3. Residual Fuel Oil This group mainly includes No. 5 and No. 6 fuel oils. They are used...types of fuels was then distributed to the PSAs. This projection was based on projections from two different sources. Oak Ridge National Laboratory ( ORNL ...nine census regions, 50 states and 173 BEAs. The supply and demand projectiSns were made for seven fuel types and four final consuming sectors. ORNL

Laboratory Directed Research and Development Program FY2016 Annual Summary of Completed Projects

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

ORNL FY 2016 Annual Summary of Laboratory Directed Research and Development Program (LDRD) Completed Projects. The Laboratory Directed Research and Development (LDRD) program at ORNL operates under the authority of DOE Order 413.2C, “Laboratory Directed Research and Development” (October 22, 2015), which establishes DOE’s requirements for the program while providing the Laboratory Director broad flexibility for program implementation. The LDRD program funds are obtained through a charge to all Laboratory programs. ORNL reports its status to DOE in March of each year.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobs, G.K.

ORNL, through The Consortium for Research on Enhancing Carbon Sequestration in Terrestrial Ecosystems (CSiTE), collaborated with The Village Botanica, Inc. (VB) on a project investigating carbon sequestration in soils and commercial products from a new sustainable crop developed from perennial Hibiscus spp. Over 500 pre-treated samples were analyzed for soil carbon content. ORNL helped design a sampling scheme for soils during the planting phase of the project. Samples were collected and prepared by VB and analyzed for carbon content by ORNL. The project did not progress to a Phase II proposal because VB declined to prepare the required proposal.

Characterization of the Old Hydrofracture Facility (OHF) waste tanks located at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, J.M.; Giaquinto, J.M.; Meeks, A.M.

1997-04-01

The Old Hydrofracture Facility (OHF) is located in Melton Valley within Waste Area Grouping (WAG) 5 and includes five underground storage tanks (T1, T2, T3, T4, and T9) ranging from 13,000 to 25,000 gal. capacity. During the period of 1996--97 there was a major effort to re-sample and characterize the contents of these inactive waste tanks. The characterization data summarized in this report was needed to address waste processing options, examine concerns dealing with the performance assessment (PA) data for the Waste Isolation Pilot Plant (WIPP), evaluate the waste characteristics with respect to the waste acceptance criteria (WAC) for WIPPmore » and Nevada Test Site (NTS), address criticality concerns, and to provide the data needed to meet DOT requirements for transporting the waste. This report discusses the analytical characterization data collected on both the supernatant and sludge samples taken from three different locations in each of the OHF tanks. The isotopic data presented in this report supports the position that fissile isotopes of uranium ({sup 233}U and {sup 235}U) do not satisfy the denature ratios required by the administrative controls stated in the ORNL LLLW waste acceptance criteria (WAC). The fissile isotope of plutonium ({sup 239}Pu and {sup 241}Pu) are diluted with thorium far above the WAC requirements. In general, the OHF sludge was found to be hazardous (RCRA) based on total metal content and the transuranic alpha activity was well above the 100 nCi/g limit for TRU waste. The characteristics of the OHF sludge relative to the WIPP WAC limits for fissile gram equivalent, plutonium equivalent activity, and thermal power from decay heat were estimated from the data in this report and found to be far below the upper boundary for any of the remote-handled transuranic waste (RH-TRU) requirements for disposal of the waste in WIPP.« less

Three-State Quantum Dot Gate FETs Using ZnS-ZnMgS Lattice-Matched Gate Insulator on Silicon

NASA Astrophysics Data System (ADS)

Karmakar, Supriya; Suarez, Ernesto; Jain, Faquir C.

2011-08-01

This paper presents the three-state behavior of quantum dot gate field-effect transistors (FETs). GeO x -cladded Ge quantum dots (QDs) are site-specifically self-assembled over lattice-matched ZnS-ZnMgS high- κ gate insulator layers grown by metalorganic chemical vapor deposition (MOCVD) on silicon substrates. A model of three-state behavior manifested in the transfer characteristics due to the quantum dot gate is also presented. The model is based on the transfer of carriers from the inversion channel to two layers of cladded GeO x -Ge quantum dots.

Oak Ridge National Laboratory Health and Safety Long-Range Plan: Fiscal years 1989--1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1989-06-01

The health and safety of its personnel is the first concern of ORNL and its management. The ORNL Health and Safety Program has the responsibility for ensuring the health and safety of all individuals assigned to ORNL activities. This document outlines the principal aspects of the ORNL Health and Safety Long-Range Plan and provides a framework for management use in the future development of the health and safety program. Each section of this document is dedicated to one of the health and safety functions (i.e., health physics, industrial hygiene, occupational medicine, industrial safety, nuclear criticality safety, nuclear facility safety, transportationmore » safety, fire protection, and emergency preparedness). Each section includes functional mission and objectives, program requirements and status, a summary of program needs, and program data and funding summary. Highlights of FY 1988 are included.« less

Daymet: Daily Surface Weather Data on a 1-km Grid for North America, Version 2.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, Peter E; Thornton, Michele M; Mayer, Benjamin W

More information: http://daymet.ornl.gov Presenter: Ranjeet Devarakonda Environmental Sciences Division Oak Ridge National Laboratory (ORNL) Daymet: Daily Surface Weather Data and Climatological Summaries provides gridded estimates of daily weather parameters for North America, including daily continuous surfaces of minimum and maximum temperature, precipitation occurrence and amount, humidity, shortwave radiation, snow water equivalent, and day length. The current data product (Version 2) covers the period January 1, 1980 to December 31, 2013 [1]. The prior product (Version 1) only covered from 1980-2008. Data are available on a daily time step at a 1-km x 1-km spatial resolution in Lambert Conformal Conic projectionmore » with a spatial extent that covers the conterminous United States, Mexico, and Southern Canada as meteorological station density allows. Daymet data can be downloaded from 1) the ORNL Distributed Active Archive Center (DAAC) search and order tools (http://daac.ornl.gov/cgi-bin/cart/add2cart.pl?add=1219) or directly from the DAAC FTP site (http://daac.ornl.gov/cgi-bin/dsviewer.pl?ds_id=1219) and 2) the Single Pixel Tool [2] and THREDDS (Thematic Real-time Environmental Data Services) Data Server [3]. The Single Pixel Data Extraction Tool allows users to enter a single geographic point by latitude and longitude in decimal degrees. A routine is executed that translates the (lon, lat) coordinates into projected Daymet (x,y) coordinates. These coordinates are used to access the Daymet database of daily-interpolated surface weather variables. Daily data from the nearest 1 km x 1 km Daymet grid cell are extracted from the database and formatted as a table with one column for each Daymet variable and one row for each day. All daily data for selected years are returned as a single (long) table, formatted for display in the browser window. At the top of this table is a link to the same data in a simple comma-separated text format, suitable for import into a spreadsheet or other data analysis software. The Single Pixel Data Extraction Tool also provides the option to download multiple coordinates programmatically. A multiple extractor script is freely available to download at http://daymet.ornl.gov/files/daymet.zip. The ORNL DAAC s THREDDS data server (TDS) provides customized visualization and access to Daymet time series of North American mosaics. Users can subset and download Daymet data via a variety of community standards, including OPeNDAP, NetCDF Subset service, and Open Geospatial Consortium (OGC) Web Map/Coverage Service. The ORNL DAAC TDS also exposes Daymet metadata through its ncISO service to facilitate harvesting Daymet metadata records into 3rd party catalogs. References: [1] Thornton, P.E., M.M. Thornton, B.W. Mayer, N. Wilhelmi, Y. Wei, R. Devarakonda, and R.B. Cook. 2014. Daymet: Daily Surface Weather Data on a 1-km Grid for North America, Version 2. Data set. Available on-line [http://daac.ornl.gov] from Oak Ridge National Laboratory Distributed Active Archive Center, Oak Ridge, Tennessee, USA. [2] Devarakonda R., et al. 2012. Daymet: Single Pixel Data Extraction Tool. Available on-line [http://daymet.ornl.go/singlepixel.html]. [3] Wei Y., et al. 2014. Daymet: Thematic Real-time Environmental Data Services. Available on-line [http://daymet.ornl.gov/thredds_tiles.html].« less

SB certification for mixture-based specification for flexible base.

DOT National Transportation Integrated Search

2012-10-01

Presentation topics: : Establish List of Qualified Producers; : Producers Responsible for Process Control/Quality Control; : Reduce TxDOT Sampling and Testing; : Expedite Aggregate Base Acceptance; : Share Responsibility (Producer/TxDOT) for Quality ...

Fluorescent immunolabeling of cancer cells by quantum dots and antibody scFv fragment.

PubMed

Zdobnova, Tatiana A; Dorofeev, Sergey G; Tananaev, Piter N; Vasiliev, Roman B; Balandin, Taras G; Edelweiss, Eveline F; Stremovskiy, Oleg A; Balalaeva, Irina V; Turchin, Ilya V; Lebedenko, Ekaterina N; Zlomanov, Vladimir P; Deyev, Sergey M

2009-01-01

Semiconductor quantum dots (QDs) coupled with cancer-specific targeting ligands are new promising agents for fluorescent visualization of cancer cells. Human epidermal growth factor receptor 2/neu (HER2/neu), overexpressed on the surface of many cancer cells, is an important target for cancer diagnostics. Antibody scFv fragments as a targeting agent for direct delivery of fluorophores offer significant advantages over full-size antibodies due to their small size, lower cross-reactivity, and immunogenicity. We have used quantum dots linked to anti-HER2/neu 4D5 scFv antibody to label HER2/neu-overexpressing live cells. Labeling of target cells was shown to have high brightness, photostability, and specificity. The results indicate that construction based on quantum dots and scFv antibody can be successfully used for cancer cell visualization.

Needs and Requirements for Future Research Reactors (ORNL Perspectives)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilas, Germina; Bryan, Chris; Gehin, Jess C.

2016-02-10

The High Flux Isotope Reactor (HFIR) is a vital national and international resource for neutron science research, production of radioisotopes, and materials irradiation. While HFIR is expected to continue operation for the foreseeable future, interest is growing in understanding future research reactors features, needs, and requirements. To clarify, discuss, and compile these needs from the perspective of Oak Ridge National Laboratory (ORNL) research and development (R&D) missions, a workshop, titled “Needs and Requirements for Future Research Reactors”, was held at ORNL on May 12, 2015. The workshop engaged ORNL staff that is directly involved in research using HFIR to collectmore » valuable input on the reactor’s current and future missions. The workshop provided an interactive forum for a fruitful exchange of opinions, and included a mix of short presentations and open discussions. ORNL staff members made 15 technical presentations based on their experience and areas of expertise, and discussed those capabilities of the HFIR and future research reactors that are essential for their current and future R&D needs. The workshop was attended by approximately 60 participants from three ORNL directorates. The agenda is included in Appendix A. This document summarizes the feedback provided by workshop contributors and participants. It also includes information and insights addressing key points that originated from the dialogue started at the workshop. A general overview is provided on the design features and capabilities of high performance research reactors currently in use or under construction worldwide. Recent and ongoing design efforts in the US and internationally are briefly summarized, followed by conclusions and recommendations.« less

Expanding Robust HCCI Operation with Advanced Valve and Fuel Control Technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szybist, J. P.; Confer, K.

2012-09-11

Delphi Automotive Systems and ORNL established this CRADA to advance the commercialization potential of the homogeneous charge compression ignition (HCCI) advanced combustion strategy for gasoline engine platforms. HCCI combustion has been shown by others to produce high diesel-like efficiency on a gasoline engine platform while simultaneously producing low NOX and particulate matter emissions. However, the commercialization barriers that face HCCI combustion are significant, with requirements for a more active engine control system, likely with next-cycle closed-loop feedback control, and with advanced valve train technologies to enable negative valve overlap conditions. In the partnership between Delphi and ORNL, each organization broughtmore » a unique and complementary set of skills to the project. Delphi has made a number of breakthroughs with production-intent valve train technologies and controls in recent years to make a part time production-intent HCCI engine plausible. ORNL has extensive knowledge and expertise with HCCI combustion, and also has a versatile research engine with hydraulic valve actuation (HVA) that is useful for guiding production of a cam-based HCCI system. Partnering these knowledge bases and capabilities was essential towards making progress to better understand HCCI combustion and the commercialization barriers that it faces. ORNL and Delphi maintained strong collaboration throughout the project. Meetings were held regularly, with additional reports, presentations, and meetings as necessary to maintain progress. Delphi provided guidance to ORNL regarding operational strategies to investigate on their single-cylinder research engine with HVA and data from their experimental multi-cylinder engine for modeling. ORNL provided single-cylinder engine data and modeling results.« less

Application of semiconductor fluorescent nanocrystals as optical probes for rapid early viral detection

NASA Astrophysics Data System (ADS)

Bentzen, Elizabeth L.; House, Frances; Tomlinson, Ian D.; Rosenthal, Sandra J.; Crowe, James E.; Wright, David D.

2005-04-01

Fluorescence is a tool widely employed in biological assays. Fluorescent semiconducting nanocrystals, quantum dots (QDs), are beginning to find their way into the tool box of many biologist, chemist and biochemist. These quantum dots are an attractive alternative to the traditional organic dyes due to their broad excitation spectra, narrow emission spectra and photostability. Non-specific binding is a frequently encountered problem with fluorescent labeling in biological assays. In these studies various cell lines were examined for non-specific binding to quantum dots. Evidence suggests that non-specific binding is related to cell type and, may be significantly reduced by functionalizing quantum dots with polyethyleneglycol ligands (PEG). In addition quantum dots were used to detect and monitor the progession of the viral glycoproteins ,F (fusion) and G (attachment), from Respiratory Syncytial Virus (RSV) in HEp-2 cells. RSV is the most common cause of lower respiratory tract infection in children worldwide and the most common cause of hospitalization of infants in the US. Antiviral therapy is available for treatment of RSV but is only effective if given within the first 48 hours of infection. Existing test methods require a virus level of at least 1000-fold of the amount needed for infection of most children and require several days to weeks to obtain results. The use of quantum dots may provide an early, rapid method for detection and provide insight into the trafficking of viral proteins during the course of infection.

Development of sandwich dot-ELISA for specific detection of Ochratoxin A and its application on to contaminated cereal grains originating from India

PubMed Central

Venkataramana, M.; Rashmi, R.; Uppalapati, Siva R.; Chandranayaka, S.; Balakrishna, K.; Radhika, M.; Gupta, Vijai K.; Batra, H. V.

2015-01-01

In the present study, generation and characterization of a highly specific monoclonal antibody (mAb) against Ochratoxin A (OTA) was undertaken. The generated mAb was further used to develop a simple, fast, and sensitive sandwich dot-ELISA (s-dot ELISA) method for detection of OTA from contaminated food grain samples. The limit of detection (LOD) of the developed enzyme-linked immunosorbent assay (ELISA) method was determined as 5.0 ng/mL of OTA. Developed method was more specific toward OTA and no cross reactivity was observed with the other tested mycotoxins such as deoxynivalenol, fumonisin B1, or aflatoxin B1. To assess the utility and reliability of the developed method, several field samples of maize, wheat and rice (n = 195) collected from different geographical regions of southern Karnataka region of India were evaluated for the OTA occurrence. Seventy two out of 195 samples (19 maize, 38 wheat, and 15 rice) were found to be contaminated by OTA by s-dot ELISA. The assay results were further co-evaluated with conventional analytical high-performance liquid chromatography (HPLC) method. Results of the s-dot ELISA are in concordance with HPLC except for three samples that were negative for OTA presence by s-dot ELISA but found positive by HPLC. Although positive by HPLC, the amount of OTA in the three samples was found to be lesser than the accepted levels (>5 μg/kg) of OTA presence in cereals. Therefore, in conclusion, the developed s-dot ELISA is a better alternative for routine cereal based food and feed analysis in diagnostic labs to check the presence of OTA over existing conventional culture based, tedious analytical methods. PMID:26074899

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Haw; Hsia, Chih-Hao

Novel Mn.sup.2+-doped quantum dots are provided. These Mn.sup.2+-doped quantum dots exhibit excellent temperature sensitivity in both organic solvents and water-based solutions. Methods of preparing the Mn.sup.2+-doped quantum dots are provided. The Mn.sup.2+-doped quantum dots may be prepared via a stepwise procedure using air-stable and inexpensive chemicals. The use of air-stable chemicals can significantly reduce the cost of synthesis, chemical storage, and the risk associated with handling flammable chemicals. Methods of temperature sensing using Mn.sup.2+-doped quantum dots are provided. The stepwise procedure provides the ability to tune the temperature-sensing properties to satisfy specific needs for temperature sensing applications. Water solubility maymore » be achieved by passivating the Mn.sup.2+-doped quantum dots, allowing the Mn.sup.2+-doped quantum dots to probe the fluctuations of local temperature in biological environments.« less

Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath, and Ribosome

Science.gov Websites

'studies of the structure and function of the ribosome", the 2009 Nobel Prize in Chemistry has been ORNL Researcher Wins Nobel Prize Oak Ridge National Laboratory Ex-ORNL Researcher Wins Nobel Prize

Quantum Dots in Diagnostics and Detection: Principles and Paradigms

PubMed Central

Pisanic, T. R.; Zhang, Y.; Wang, T. H.

2014-01-01

Quantum dots are semiconductor nanocrystals that exhibit exceptional optical and electrical behaviors not found in their bulk counterparts. Following seminal work in the development of water-soluble quantum dots in the late 1990's, researchers have sought to develop interesting and novel ways of exploiting the extraordinary properties of quantum dots for biomedical applications. Since that time, over 10,000 articles have been published related to the use of quantum dots in biomedicine, many of which regard their use in detection and diagnostic bioassays. This review presents a didactic overview of fundamental physical phenomena associated with quantum dots and paradigm examples of how these phenomena can and have been readily exploited for manifold uses in nanobiotechnology with a specific focus on their implementation in in vitro diagnostic assays and biodetection. PMID:24770716

Bifunctional Carbon-Dot-WS2 Nanorods for Photothermal Therapy and Cell Imaging.

PubMed

Nandi, Sukhendu; Bhunia, Susanta Kumar; Zeiri, Leila; Pour, Maayan; Nachman, Iftach; Raichman, Daniel; Lellouche, Jean-Paul Moshe; Jelinek, Raz

2017-01-18

Multifunctional nanoparticles have attracted significant interest as biomedical vehicles, combining diagnostic, imaging, and therapeutic properties. We describe herein the construction of new nanoparticle conjugates comprising WS 2 nanorods (NRs) coupled to fluorescent carbon dots (C-dots). We show that the WS 2 -C-dot hybrids integrate the unique physical properties of the two species, specifically the photothermal activity of the WS 2 NRs upon irradiation with near-infrared (NIR) light and the excitation-dependent luminescence emission of the C-dots. The WS 2 -C-dot NRs have been shown to be non-cytotoxic and have been successfully employed for multicolour cell imaging and targeted cell killing under NIR irradiation, pointing to their potential utilization as effective therapeutic vehicles. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Quantum dot bioconjugates for ultrasensitive nonisotopic detection.

PubMed

Chan, W C; Nie, S

1998-09-25

Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.

Interplay of coupling and superradiant emission in the optical response of a double quantum dot

NASA Astrophysics Data System (ADS)

Sitek, Anna; Machnikowski, Paweł

2009-09-01

We study theoretically the optical response of a double quantum dot structure to an ultrafast optical excitation. We show that the interplay of a specific type of coupling between the dots and their collective interaction with the radiative environment leads to very characteristic features in the time-resolved luminescence as well as in the absorption spectrum of the system. For a sufficiently strong coupling, these effects survive even if the transition energy mismatch between the two dots exceeds by far the emission linewidth.

Comparative evaluation of several small mammal species as monitors of heavy metals, radionuclides, and selected organic compounds in the environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Talmage, S.S.; Walton, B.T.

1990-08-01

The primary purpose of this study was to evaluate which small mammal species are the best monitors of specific environmental contaminants. The evaluation is based on the published literature and on an analysis of small mammals trapped at several sites on the Oak Ridge National Laboratory (ORNL) Reservation in Oak Ridge, Tennessee. Studies on the uptake of heavy metals, radionuclides, and organic chemicals are reviewed in Chapter II to evaluate several small mammal species for their capacity to serve as sentinels for the presence, accumulation, and effects of various contaminants. Where several species were present at a site, a comparativemore » evaluation was made and species are ranked for their capacity to serve as monitors of specific contaminants. Food chain accumulation and food habits of the species are used to establish a relationship with suitability as a biomonitor. Tissue-specific concentration factors were noted in order to establish target tissues. Life histories, habitat, and food habits are reviewed in order to make generalizations concerning the ability of similar taxa to serve as biomonitor. Finally, the usefulness of several small mammal species as monitors of three contaminants -- benzo(a)pyrene, mercury, and strontium-90 -- present on or near the ORNL facilities was investigated. 133 refs., 5 figs., 20 tabs.« less

Simple Identification of Human Taenia Species by Multiplex Loop-Mediated Isothermal Amplification in Combination with Dot Enzyme-Linked Immunosorbent Assay.

PubMed

Nkouawa, Agathe; Sako, Yasuhito; Okamoto, Munehiro; Ito, Akira

2016-06-01

For differential detection of Taenia solium, Taenia saginata, and Taenia asiatica, loop-mediated isothermal amplification (LAMP) assay targeting the cytochrome c oxidase subunit 1 gene has been recently developed and shown to be sensitive, specific, and effective. However, to achieve differential identification, one specimen requires three reaction mixtures containing a primer set of each Taenia species separately, which is complex and time consuming and increases the risk of cross-contamination. In this study, we developed a simple differential identification of human Taenia species using multiplex LAMP (mLAMP) in combination with dot enzyme-linked immunosorbent assay (dot-ELISA). Forward inner primers of T. solium, T. saginata, and T. asiatica labeled with fluorescein isothiocyanate (FITC), digoxigenin (DIG), and tetramethylrhodamine (TAMRA), respectively, and biotin-labeled backward inner primers were used in mLAMP. The mLAMP assay succeeded in specific amplification of each respective target gene in a single tube. Furthermore, the mLAMP product from each species was easily distinguished by dot-ELISA with an antibody specific for FITC, DIG, or TAMRA. The mLAMP assay in combination with dot-ELISA will make identification of human Taenia species simpler, easier, and more practical. © The American Society of Tropical Medicine and Hygiene.

Cross-validation of the Dot Counting Test in a large sample of credible and non-credible patients referred for neuropsychological testing.

PubMed

McCaul, Courtney; Boone, Kyle B; Ermshar, Annette; Cottingham, Maria; Victor, Tara L; Ziegler, Elizabeth; Zeller, Michelle A; Wright, Matthew

2018-01-18

To cross-validate the Dot Counting Test in a large neuropsychological sample. Dot Counting Test scores were compared in credible (n = 142) and non-credible (n = 335) neuropsychology referrals. Non-credible patients scored significantly higher than credible patients on all Dot Counting Test scores. While the original E-score cut-off of ≥17 achieved excellent specificity (96.5%), it was associated with mediocre sensitivity (52.8%). However, the cut-off could be substantially lowered to ≥13.80, while still maintaining adequate specificity (≥90%), and raising sensitivity to 70.0%. Examination of non-credible subgroups revealed that Dot Counting Test sensitivity in feigned mild traumatic brain injury (mTBI) was 55.8%, whereas sensitivity was 90.6% in patients with non-credible cognitive dysfunction in the context of claimed psychosis, and 81.0% in patients with non-credible cognitive performance in depression or severe TBI. Thus, the Dot Counting Test may have a particular role in detection of non-credible cognitive symptoms in claimed psychiatric disorders. Alternative to use of the E-score, failure on ≥1 cut-offs applied to individual Dot Counting Test scores (≥6.0″ for mean grouped dot counting time, ≥10.0″ for mean ungrouped dot counting time, and ≥4 errors), occurred in 11.3% of the credible sample, while nearly two-thirds (63.6%) of the non-credible sample failed one of more of these cut-offs. An E-score cut-off of 13.80, or failure on ≥1 individual score cut-offs, resulted in few false positive identifications in credible patients, and achieved high sensitivity (64.0-70.0%), and therefore appear appropriate for use in identifying neurocognitive performance invalidity.

Fusion Materials Research at Oak Ridge National Laboratory in Fiscal Year 2015

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiffen, F. W.; Katoh, Yutai; Melton, Stephanie G.

The realization of fusion energy is a formidable challenge with significant achievements resulting from close integration of the plasma physics and applied technology disciplines. Presently, the most significant technological challenge for the near-term experiments such as ITER, and next generation fusion power systems, is the inability of current materials and components to withstand the harsh fusion nuclear environment. The overarching goal of the Oak Ridge National Laboratory (ORNL) fusion materials program is to provide the applied materials science support and understanding to underpin the ongoing Department of Energy (DOE) Office of Science fusion energy program while developing materials for fusionmore » power systems. In doing so the program continues to be integrated both with the larger United States (US) and international fusion materials communities, and with the international fusion design and technology communities.This document provides a summary of Fiscal Year (FY) 2015 activities supporting the Office of Science, Office of Fusion Energy Sciences Materials Research for Magnetic Fusion Energy (AT-60-20-10-0) carried out by ORNL. The organization of this report is mainly by material type, with sections on specific technical activities. Four projects selected in the Funding Opportunity Announcement (FOA) solicitation of late 2011 and funded in FY2012-FY2014 are identified by “FOA” in the titles. This report includes the final funded work of these projects, although ORNL plans to continue some of this work within the base program.« less

41 CFR 102-173.95 - Are there any restrictions on the use of the dot-gov domain name?

Code of Federal Regulations, 2012 CFR

2012-01-01

... restrictions on the use of the dot-gov domain name? 102-173.95 Section 102-173.95 Public Contracts and Property... TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.95 Are there any restrictions on the use of the dot-gov domain name? The General Services Administration approves domain names for a specific term of time...

41 CFR 102-173.95 - Are there any restrictions on the use of the dot-gov domain name?

Code of Federal Regulations, 2013 CFR

2013-07-01

... restrictions on the use of the dot-gov domain name? 102-173.95 Section 102-173.95 Public Contracts and Property... TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.95 Are there any restrictions on the use of the dot-gov domain name? The General Services Administration approves domain names for a specific term of time...

41 CFR 102-173.95 - Are there any restrictions on the use of the dot-gov domain name?

Code of Federal Regulations, 2011 CFR

2011-01-01

... restrictions on the use of the dot-gov domain name? 102-173.95 Section 102-173.95 Public Contracts and Property... TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.95 Are there any restrictions on the use of the dot-gov domain name? The General Services Administration approves domain names for a specific term of time...

41 CFR 102-173.95 - Are there any restrictions on the use of the dot-gov domain name?

Code of Federal Regulations, 2010 CFR

2010-07-01

... restrictions on the use of the dot-gov domain name? 102-173.95 Section 102-173.95 Public Contracts and Property... TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.95 Are there any restrictions on the use of the dot-gov domain name? The General Services Administration approves domain names for a specific term of time...

41 CFR 102-173.95 - Are there any restrictions on the use of the dot-gov domain name?

Code of Federal Regulations, 2014 CFR

2014-01-01

... restrictions on the use of the dot-gov domain name? 102-173.95 Section 102-173.95 Public Contracts and Property... TELECOMMUNICATIONS 173-INTERNET GOV DOMAIN Registration § 102-173.95 Are there any restrictions on the use of the dot-gov domain name? The General Services Administration approves domain names for a specific term of time...

ORNL-GM: Development of Ionic Liquid-Additized, GF-5/6 Compatible Low-Viscosity Oils for Automotive Engine and Rear Axle Lubrication for 4% Improved Fuel Economy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qu, Jun; Zhou, Yan; Luo, Huimin

The overall objective of this project are as follows: Further develop ionic liquid (IL)-additized lowviscosity engine oils meeting the GF-5/6 specifications and possessing superior lubricating characteristics; Expand the IL additive technology to rear axle lubricants; and Seek a combined improvement in the vehicle fuel economy

Assessment of public involvement

DOT National Transportation Integrated Search

2011-01-31

The Texas Department of Transportation (TxDOT) employs a range of methods and strategies to incorporate Texans in the many aspects of planning, project implementation and partnerships. This public involvement process is supported by TxDOT specific, s...

Human radiation studies: Remembering the early years: Oral history of health physicist Karl Z. Morgan, Ph.D., conducted January 7, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-06-01

This report provided a transcript of an interview of Dr. Karl. Z. Morgan by representatives of the DOE Office of Human Radiation Experiments. Dr. Morgan was selected for this interview because of his research for the Manhattan Project at the Metallurgical Laboratory in Chicago and his work at the Oak Ridge National Laboratory (ORNL). The oral history covers Dr. Morgan`s work as a pioneer in the field of Health Physics, his research at ORNL and his work since he retired from ORNL.

New membranes could speed the biofuels conversion process and reduce cost

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Michael

2014-07-23

ORNL researchers have developed a new class of membranes that could enable faster, more cost efficient biofuels production. These membranes are tunable at the nanopore level and have potential uses in separating water from fuel and acid from bio-oils. The membrane materials technology just won an R&D 100 award. ORNL and NREL are partnering, with support from the DOE Bioenergy Technologies Office, to determine the best uses of these membranes to speed the biofuels conversion process. Development of the membranes was funded by DOE BETO and ORNL's Laboratory Directed Research and Development Program.

New membranes could speed the biofuels conversion process and reduce cost

ScienceCinema

Hu, Michael

2018-01-26

ORNL researchers have developed a new class of membranes that could enable faster, more cost efficient biofuels production. These membranes are tunable at the nanopore level and have potential uses in separating water from fuel and acid from bio-oils. The membrane materials technology just won an R&D 100 award. ORNL and NREL are partnering, with support from the DOE Bioenergy Technologies Office, to determine the best uses of these membranes to speed the biofuels conversion process. Development of the membranes was funded by DOE BETO and ORNL's Laboratory Directed Research and Development Program.

Automated Metrology System for Pu 238

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wunderlich, Richard J.

Under a collaborative partnership between the NASA and DOE, a new automated measurement system developed by ORNL will ensure quality production of plutonium-238 while reducing handling by workers. NASA has funded ORNL and other national laboratories to develop a process that will restore US production capability of Pu-238 for the first time since the late 1980s when the Savannah River Plant ceased production. ORNL has produced and separated about 100 grams of the material and plans to scale up the process over the next several years to meet demand to power NASA deep space missions.

Science alliance: A vital ORNL-UT partnership

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richmond, C.R.; Riedinger, L.; Garritano, T.

1991-01-01

Partnerships between Department of Energy national laboratories and universities have long been keys to advancing scientific research and education in the United States. Perhaps the most enduring and closely knit of these relationships is the one between Oak Ridge National Laboratory and the University of Tennessee at Knoxville. Since its birth in the 1940's, ORNL has had a very special relationship with UT, and today the two institutions have closer ties than virtually any other university and national laboratory. Seven years ago, ORNL and UT began a new era of cooperation by creating the Science Alliance, a Center of Excellencemore » at UT sponsored by the Tennessee Higher Education Commission. As the oldest and largest of these centers, the Science Alliance is the primary vehicle through which Tennessee promotes research and educational collaboration between UT and ORNL. By letting the two institutions pool their intellectual and financial resources, the alliance creates a more fertile scientific environment than either could achieve on its own. Part of the UT College of Liberal Arts, the Science Alliance is composed of four divisions (Biological Sciences, Chemical Sciences, Physical Sciences, and Mathematics and Computer Science) that team 100 of the university's top faculty with their outstanding colleagues from ORNL.« less

Quantum dot-based western blot for sensitive detection of pig serum antibody to actinobacillus pleuropneumoniae

NASA Astrophysics Data System (ADS)

Cişmileanu, Ana; Sima, Cornelia; Grigoriu, Constantin

2007-08-01

A quantum dot - immunoglobulin conjugate specific for pig IgG, was obtained by carbodiimide chemistry. We used a Western blot technique for detecting specific antibodies against Actinobacillus pleuropneumoniae (A. pp), which cause porcine pleuropneumonia. The antigen used in this technique was Apx haemolysin which is an important virulence factor of A. pp and it induces protective immunity in vaccined pigs. The detection on Western blot membrane was possible at 1/50 dilution of quantum dot conjugate at a dilution of pig serum till 1/6400. The results for pig serum demonstrated a higher sensitivity of QD-based Western blot technique for the presence of antibodies specific for Apx haemolysin in comparison with similar classical techniques (with coloured substrate for enzyme present in secondary antibody conjugate).

Leaky coaxial cable signal transmission for remote facilities

NASA Astrophysics Data System (ADS)

Smith, S. F.; Crutcher, R. I.

To develop reliable communications methods to meet the rigorous requirements for nuclear hot cells and similar environments, including control of cranes, transporters, and advanced servomanipulators, the Consolidated Fuel Reprocessing Program (CFRP) at Oak Ridge National Laboratory (ORNL) has conducted extensive tests of numerous technologies to determine their applicability to remote operations. To alleviate the need for large bundles of cables that must accommodate crane/transporter motion relative to the boundaries of the cell, several transmission techniques are available, including slotted-line radio-frequency couplers, infrared beams, fiber-optic cables, free-space microwave, and inductively coupled leaky coaxial cable. This paper discusses the general characteristics, mode of operation, and proposed implementation of leaky coaxial cable technology in a waste-handling facility scheduled to be built in the near future at ORNL. In addition, specific system hardware based around the use of leaky coaxial cable is described in detail. Finally, data from a series of radiation exposure tests conducted by the CFRP on several samples of the basic leaky coaxial cable and associated connectors are presented.

Microscopy of semiconducting materials

NASA Astrophysics Data System (ADS)

Pennycook, S. J.

1991-04-01

The purpose of the trip was to present an invited talk at the 7th Oxford Conference on Microscopy of Semiconducting Materials entitled, High-Resolution Z-Contrast Imaging of Heterostructures and Superlattices, (Oxford, United Kingdom) and to visit VG Microscopes, East Grinstead, for discussions on the progress of the Oak Ridge National Laboratory (ORNL) 300-kV high-resolution scanning transmission electron microscope (STEM), which is currently on order. The traveler also visited three other institutions with 100-kV STEMs that either have or intend to purchase the necessary modifications to provide Z-contrast capability similar to that of the existing ORNL machine. Specifically, Max-Planck Institut fuer Metallforschung (Stuttgart, Germany); Cambridge University, Department of Materials Science and Metallurgy (Cambridge, United Kingdom); and Cavendish Laboratory, Cambridge University (Cambridge, United Kingdom) were visited. In addition, discussions were held with C. Humphreys on the possibility of obtaining joint funding for collaborative research involving electron beam writing and Z-contrast imaging in the Cambridge and Oak Ridge STEMs, respectively.

Searching for the optimal synthesis parameters of InP/CdxZn1-xSe quantum dots when combined with a broad band phosphor to optimize color rendering and efficacy of a hybrid remote phosphor white LED

NASA Astrophysics Data System (ADS)

Ryckaert, Jana; Correia, António; Smet, Kevin; Tessier, Mickael D.; Dupont, Dorian; Hens, Zeger; Hanselaer, Peter; Meuret, Youri

2017-09-01

Combining traditional phosphors with a broad emission spectrum and non-scattering quantum dots with a narrow emission spectrum can have multiple advantages for white LEDs. It allows to reduce the amount of scattering in the wavelength conversion element, increasing the efficiency of the complete system. Furthermore, the unique possibility to tune the emission spectrum of quantum dots allows to optimize the resulting LED spectrum in order to achieve optimal color rendering properties for the light source. However, finding the optimal quantum dot properties to achieve optimal efficacy and color rendering is a non-trivial task. Instead of simply summing up the emission spectra of the blue LED, phosphor and quantum dots, we propose a complete simulation tool that allows an accurate analysis of the final performance for a range of different quantum dot synthesis parameters. The recycling of the reflected light from the wavelength conversion element by the LED package is taken into account, as well as the re-absorption and the associated red-shift. This simulation tool is used to vary two synthesis parameters (core size and cadmium fraction) of InP/CdxZn1-xSe quantum dots. We find general trends for the ideal quantum dot that should be combined with a specific YAG:Ce broad band phosphor to obtain optimal efficiency and color rendering for a white LED with a specific pumping LED and recycling cavity, with a desired CCT of 3500K.

Crystal structure of MboIIA methyltransferase.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osipiuk, J.; Walsh, M. A.; Joachimiak, A.

2003-09-15

DNA methyltransferases (MTases) are sequence-specific enzymes which transfer a methyl group from S-adenosyl-L-methionine (AdoMet) to the amino group of either cytosine or adenine within a recognized DNA sequence. Methylation of a base in a specific DNA sequence protects DNA from nucleolytic cleavage by restriction enzymes recognizing the same DNA sequence. We have determined at 1.74 {angstrom} resolution the crystal structure of a {beta}-class DNA MTase MboIIA (M {center_dot} MboIIA) from the bacterium Moraxella bovis, the smallest DNA MTase determined to date. M {center_dot} MboIIA methylates the 3' adenine of the pentanucleotide sequence 5'-GAAGA-3'. The protein crystallizes with two molecules inmore » the asymmetric unit which we propose to resemble the dimer when M {center_dot} MboIIA is not bound to DNA. The overall structure of the enzyme closely resembles that of M {center_dot} RsrI. However, the cofactor-binding pocket in M {center_dot} MboIIA forms a closed structure which is in contrast to the open-form structures of other known MTases.« less

Photonic emitters and circuits based on colloidal quantum dot composites

NASA Astrophysics Data System (ADS)

Menon, Vinod M.; Husaini, Saima; Valappil, Nikesh; Luberto, Matthew

2009-02-01

We discuss our work on light emitters and photonic circuits realized using colloidal quantum dot composites. Specifically we will report our recent work on flexible microcavity laser, microdisk emitters and integrated active - passive waveguides. The entire microcavity laser structure was realized using spin coating and consisted of an all-polymer distributed Bragg reflector with a poly-vinyl carbazole cavity layer embedded with InGaP/ZnS colloidal quantum dots. These microcavities can be peeled off the substrate yielding a flexible structure that can conform to any shape and whose emission spectra can be mechanically tuned. The microdisk emitters and the integrated waveguide structures were realized using soft lithography and photo-lithography, respectively and were fabricated using a composite consisting of quantum dots embedded in SU8 matrix. Finally, we will discuss the effect of the host matrix on the optical properties of the quantum dots using results of steady-state and time-resolved luminescence measurements. In addition to their specific functionalities, these novel device demonstrations and their development present a low cost alternative to the traditional photonic device fabrication techniques.

ORNL Named as Part of IAES Research Reactor Hub

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The International Atomic Energy Agency (IAEA) has named ORNL and Idaho National Laboratory part of an International Centre based on Research Reactors. The designation makes the United States one of only three countries identified for unique capabilities and excellence in nuclear research.

Developing a mixture design specification for flexible base construction.

DOT National Transportation Integrated Search

2012-06-01

In the Texas Department of Transportation (TxDOT), flexible base producers typically generate large stockpiles of material exclusively for TxDOT projects. This large state-only inventory often maintained by producers, along with time requiremen...

Visual feature-tolerance in the reading network.

PubMed

Rauschecker, Andreas M; Bowen, Reno F; Perry, Lee M; Kevan, Alison M; Dougherty, Robert F; Wandell, Brian A

2011-09-08

A century of neurology and neuroscience shows that seeing words depends on ventral occipital-temporal (VOT) circuitry. Typically, reading is learned using high-contrast line-contour words. We explored whether a specific VOT region, the visual word form area (VWFA), learns to see only these words or recognizes words independent of the specific shape-defining visual features. Word forms were created using atypical features (motion-dots, luminance-dots) whose statistical properties control word-visibility. We measured fMRI responses as word form visibility varied, and we used TMS to interfere with neural processing in specific cortical circuits, while subjects performed a lexical decision task. For all features, VWFA responses increased with word-visibility and correlated with performance. TMS applied to motion-specialized area hMT+ disrupted reading performance for motion-dots, but not line-contours or luminance-dots. A quantitative model describes feature-convergence in the VWFA and relates VWFA responses to behavioral performance. These findings suggest how visual feature-tolerance in the reading network arises through signal convergence from feature-specialized cortical areas. Copyright © 2011 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ekkebus, Allen E

Oak Ridge National Laboratory hosted two workshops in April 2007 relevant to nuclear engineering education. In the Neutron Stress, Texture, and Phase Transformation for Industry workshop [http://neutrons.ornl.gov/workshops/nst2/], several invited speakers gave examples of neutron stress mapping for nuclear engineering applications. These included John Root of National Research Council of Canada, Mike Fitzpatrick of the UK's Open University, and Yan Gao of GE Global Research on their experiences with industrial and academic uses of neutron diffraction. Xun-Li Wang and Camden Hubbard described the new instruments at ORNL that can be used for such studies. This was preceded by the Neutrons formore » Materials Science and Engineering educational symposium [http://neutrons.ornl.gov/workshops/edsym2007]. It was directed to the broad materials science and engineering community based in universities, industry and laboratories who wish to learn what the neutron sources in the US can provide for enhancing the understanding of materials behavior, processing and joining. Of particular interest was the presentation of Donald Brown of Los Alamos about using 'Neutron diffraction measurements of strain and texture to study mechanical behavior of structural materials.' At both workshops, the ORNL neutron scattering instruments relevant to nuclear engineering studies were described. The Neutron Residual Stress Mapping Facility (NRSF2) is currently in operation at the High Flux Isotope Reactor; the VULCAN Engineering Materials Diffractometer will begin commissioning in 2008 at the Spallation Neutron Source. For characteristics of these instruments, as well as details of other workshops, meetings, capabilities, and research proposal submissions, please visit http://neutrons.ornl.gov. To submit user proposals for time on NRSF2 contact Hubbard at hubbardcr@ornl.gov.« less

In vitro uptake of apoptotic body mimicking phosphatidylserine-quantum dot micelles by monocytic cell line

NASA Astrophysics Data System (ADS)

Maiseyeu, Andrei; Bagalkot, Vaishali

2014-04-01

A new quantum dot (QD) PEGylated micelle laced with phosphatidylserine (PS) for specific scavenger receptor-mediated uptake by macrophages is reported. The size and surface chemistry of PS-QD micelles were characterized by standard methods and the effects of their physicochemical properties on specific targeting and uptake were comprehensively studied in a monocytic cell line (J774A.1).

Bottom-up electrochemical preparation of solid-state carbon nanodots directly from nitriles/ionic liquids using carbon-free electrodes and the applications in specific ferric ion detection and cell imaging

NASA Astrophysics Data System (ADS)

Niu, Fushuang; Xu, Yuanhong; Liu, Mengli; Sun, Jing; Guo, Pengran; Liu, Jingquan

2016-03-01

Carbon nanodots (C-dots), a new type of potential alternative to conventional semiconductor quantum dots, have attracted numerous attentions in various applications including bio-chemical sensing, cell imaging, etc., due to their chemical inertness, low toxicity and flexible functionalization. Various methods including electrochemical (EC) methods have been reported for the synthesis of C-dots. However, complex procedures and/or carbon source-containing electrodes are often required. Herein, solid-state C-dots were simply prepared by bottom-up EC carbonization of nitriles (e.g. acetonitrile) in the presence of an ionic liquid [e.g. 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6)], using carbon-free electrodes. Due to the positive charges of BMIM+ on the C-dots, the final products presented in a precipitate form on the cathode, and the unreacted nitriles and BMIMPF6 can be easily removed by simple vacuum filtration. The as-prepared solid-state C-dots can be well dispersed in an aqueous medium with excellent photoluminescence properties. The average size of the C-dots was found to be 3.02 +/- 0.12 nm as evidenced by transmission electron microscopy. Other techniques such as UV-vis spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy and atomic force microscopy were applied for the characterization of the C-dots and to analyze the possible generation mechanism. These C-dots have been successfully applied in efficient cell imaging and specific ferric ion detection.Carbon nanodots (C-dots), a new type of potential alternative to conventional semiconductor quantum dots, have attracted numerous attentions in various applications including bio-chemical sensing, cell imaging, etc., due to their chemical inertness, low toxicity and flexible functionalization. Various methods including electrochemical (EC) methods have been reported for the synthesis of C-dots. However, complex procedures and/or carbon source-containing electrodes are often required. Herein, solid-state C-dots were simply prepared by bottom-up EC carbonization of nitriles (e.g. acetonitrile) in the presence of an ionic liquid [e.g. 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6)], using carbon-free electrodes. Due to the positive charges of BMIM+ on the C-dots, the final products presented in a precipitate form on the cathode, and the unreacted nitriles and BMIMPF6 can be easily removed by simple vacuum filtration. The as-prepared solid-state C-dots can be well dispersed in an aqueous medium with excellent photoluminescence properties. The average size of the C-dots was found to be 3.02 +/- 0.12 nm as evidenced by transmission electron microscopy. Other techniques such as UV-vis spectroscopy, fluorescence spectroscopy, X-ray photoelectron spectroscopy and atomic force microscopy were applied for the characterization of the C-dots and to analyze the possible generation mechanism. These C-dots have been successfully applied in efficient cell imaging and specific ferric ion detection. Electronic supplementary information (ESI) available: Fig. S1. TEM image of the products generated via an electrochemical method using pure BMIMBF4 aqueous solution as the electrolyte; Fig. S2. TEM and HRTEM (inset) images of the water-dispersed solution of C-dots generated from the EC process using electrolytes with a BMIMPF6/3-methylaminopropionitrile volume ratio of 1 : 9 Fig. S3. The effect of pH on the fluorescence intensity (I) of the C-dots; experimental details for detection of Fe3+ in tap water; Fig. S4. Calibration curve for detection of Fe3+ in tap water using the standard addition method. See DOI: 10.1039/c6nr00023a

Technical Data to Justify Full Burnup Credit in Criticality Safety Licensing Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Enercon Services, Inc.

2011-03-14

Enercon Services, Inc. (ENERCON) was requested under Task Order No.2 to identify scientific and technical data needed to benchmark and justify Full Burnup Credit, which adds 16 fission products and 4 minor actinides1 to Actinide-Only burnup credit. The historical perspective for Full Burnup Credit is discussed, and interviews of organizations participating in burnup credit activities are summarized as a basis for identifying additional data needs and making recommendation. Input from burnup credit participants representing two segments of the commercial nuclear industry is provided. First, the Electric Power Research Institute (EPRI) has been very active in the development of Full Burnupmore » Credit, representing the interests of nuclear utilities in achieving capacity gains for storage and transport casks. EPRI and its utility customers are interested in a swift resolution of the validation issues that are delaying the implementation of Full Burnup Credit [EPRI 2010b]. Second, used nuclear fuel storage and transportation Cask Vendors favor improving burnup credit beyond Actinide-Only burnup credit, although their discussion of specific burnup credit achievements and data needs was limited citing business sensitive and technical proprietary concerns. While Cask Vendor proprietary items are not specifically identified in this report, the needs of all nuclear industry participants are reflected in the conclusions and recommendations of this report. In addition, Oak Ridge National Laboratory (ORNL) and Sandia National Laboratory (SNL) were interviewed for their input into additional data needs to achieve Full Burnup Credit. ORNL was very open to discussions of Full Burnup Credit, with several telecoms and a visit by ENERCON to ORNL. For many years, ORNL has provided extensive support to the NRC regarding burnup credit in all of its forms. Discussions with ORNL focused on potential resolutions to the validation issues for the use of fission products. SNL was helpful in ENERCON's understanding of the difficult issues related to obtaining and analyzing additional cross section test data to support Full Burnup Credit. A PIRT (Phenomena Identification and Ranking Table) analysis was performed by ENERCON to evaluate the costs and benefits of acquiring different types of nuclear data in support of Full Burnup Credit. A PIRT exercise is a formal expert elicitation process with the final output being the ranking tables. The PIRT analysis (Table 7-4: Results of PIRT Evaluation) showed that the acquisition of additional Actinide-Only experimental data, although beneficial, was associated with high cost and is not necessarily needed. The conclusion was that the existing Radiochemical Assay (RCA) data plus the French Haut Taux de Combustion (HTC)2 and handbook Laboratory Critical Experiment (LCE) data provide adequate benchmark validation for Actinide-Only Burnup Credit. The PIRT analysis indicated that the costs and schedule to obtain sufficient additional experimental data to support the addition of 16 fission products to Actinide-Only Burnup Credit to produce Full Burnup Credit are quite substantial. ENERCON estimates the cost to be $50M to $100M with a schedule of five or more years. The PIRT analysis highlights another option for fission product burnup credit, which is the application of computer-based uncertainty analyses (S/U - Sensitivity/Uncertainty methodologies), confirmed by the limited experimental data that is already available. S/U analyses essentially transform cross section uncertainty information contained in the cross section libraries into a reactivity bias and uncertainty. Recent work by ORNL and EPRI has shown that a methodology to support Full Burnup Credit is possible using a combination of traditional RCA and LCE validation plus S/U validation for fission product isotopics and cross sections. Further, the most recent cross section data (ENDF/B-VII) can be incorporated into the burnup credit codes at a reasonable cost compared to the acquisition of equivalent experimental data. ENERCON concludes that even with the costs of code data library updating, the use of S/U analysis methodologies could be accomplished on a shorter schedule and a lower cost than the gathering of sufficient experimental data. ENERCON estimates of the costs of an updated S/U computer code and data suite are $5M to $10M with a schedule of two to three years. Recent ORNL analyses using the S/U analysis method show that the bias and uncertainty values for fission product cross sections are smaller than previously expected. This result is confirmed by a similar EPRI approach using different data and computer codes. ENERCON also found that some issues regarding the implementation of burnup credit appear to have been successfully resolved especially the axial burnup profile issue and the depletion parameter issue. These issues were resolved through data gathering activities at the Yucca Mountain Project and ORNL.« less

Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy

PubMed Central

Holzman, Samuel B; Zenilman, Avi; Shah, Maunank

2018-01-01

Abstract Background Directly observed therapy (DOT) remains an integral component of treatment support and adherence monitoring in tuberculosis care. In-person DOT is resource intensive and often burdensome for patients. Video DOT (vDOT) has been proposed as an alternative to increase treatment flexibility and better meet patient-specific needs. Methods We conducted a pragmatic, prospective pilot implementation of vDOT at 3 TB clinics in Maryland. A mixed-methods approach was implemented to assess (1) effectiveness, (2) acceptability, and (3) cost. Medication adherence on vDOT was compared with that of in-person DOT. Interviews and surveys were conducted with patients and providers before and after implementation, with framework analysis utilized to extract salient themes. Last, a cost analysis assessed the economic impacts of vDOT implementation across heterogeneous clinic structures. Results Medication adherence on vDOT was comparable to that of in-person DOT (94% vs 98%, P = .17), with a higher percentage of total treatment doses (inclusive of weekend/holiday self-administration) ultimately observed during the vDOT period (72% vs 66%, P = .03). Video DOT was well received by staff and patients alike, who cited increased treatment flexibility, convenience, and patient privacy. Our cost analysis estimated a savings with vDOT of $1391 per patient for a standard 6-month treatment course. Conclusions Video DOT is an acceptable and important option for measurement of TB treatment adherence and may allow a higher proportion of prescribed treatment doses to be observed, compared with in-person DOT. Video DOT may be cost-saving and should be considered as a component of individualized, patient-centered case management plans. PMID:29732378

Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy.

PubMed

Holzman, Samuel B; Zenilman, Avi; Shah, Maunank

2018-04-01

Directly observed therapy (DOT) remains an integral component of treatment support and adherence monitoring in tuberculosis care. In-person DOT is resource intensive and often burdensome for patients. Video DOT (vDOT) has been proposed as an alternative to increase treatment flexibility and better meet patient-specific needs. We conducted a pragmatic, prospective pilot implementation of vDOT at 3 TB clinics in Maryland. A mixed-methods approach was implemented to assess (1) effectiveness, (2) acceptability, and (3) cost. Medication adherence on vDOT was compared with that of in-person DOT. Interviews and surveys were conducted with patients and providers before and after implementation, with framework analysis utilized to extract salient themes. Last, a cost analysis assessed the economic impacts of vDOT implementation across heterogeneous clinic structures. Medication adherence on vDOT was comparable to that of in-person DOT (94% vs 98%, P = .17), with a higher percentage of total treatment doses (inclusive of weekend/holiday self-administration) ultimately observed during the vDOT period (72% vs 66%, P = .03). Video DOT was well received by staff and patients alike, who cited increased treatment flexibility, convenience, and patient privacy. Our cost analysis estimated a savings with vDOT of $1391 per patient for a standard 6-month treatment course. Video DOT is an acceptable and important option for measurement of TB treatment adherence and may allow a higher proportion of prescribed treatment doses to be observed, compared with in-person DOT. Video DOT may be cost-saving and should be considered as a component of individualized, patient-centered case management plans.

ORNL takes energy-efficient housing to a new level

ScienceCinema

None

2017-12-09

Oak Ridge National Laboratory, TVA and the Department of Energy are taking energy-saving research into a West Knox County neighborhood. In the Campbell Creek subdivision, ORNL researchers have helped builders to construct three homes with three different levels of energy-saving features.

Final Inventory Work-Off Plan for ORNL transuranic wastes (1986 version)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickerson, L.S.

1988-05-01

The Final Inventory Work-Off Plan (IWOP) for ORNL Transuranic Wastes addresses ORNL's strategy for retrieval, certification, and shipment of its stored and newly generated contact-handled (CH) and remote-handled (RH) transuranic (TRU) wastes to the Waste Isolation Pilot Plant (WIPP), the proposed geologic repository near Carlsbad, New Mexico. This document considers certification compliance with the WIPP waste acceptance criteria (WAC) and is consistent with the US Department of Energy's Long-Range Master Plan for Defense Transuranic Waste Management. This document characterizes Oak Ridge National Laboratory's (ORNL's) TRU waste by type and estimates the number of shipments required to dispose of it; describesmore » the methods, facilities, and systems required for its certification and shipment; presents work-off strategies and schedules for retrieval, certification, and transportation; discusses the resource needs and additions that will be required for the effort and forecasts costs for the long-term TRU waste management program; and lists public documentation required to support certification facilities and strategies. 22 refs., 6 figs., 10 tabs.« less

Oak Ridge National Laboratory Support of Non-light Water Reactor Technologies: Capabilities Assessment for NRC Near-term Implementation Action Plans for Non-light Water Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Belles, Randy; Jain, Prashant K.; Powers, Jeffrey J.

The Oak Ridge National Laboratory (ORNL) has a rich history of support for light water reactor (LWR) and non-LWR technologies. The ORNL history involves operation of 13 reactors at ORNL including the graphite reactor dating back to World War II, two aqueous homogeneous reactors, two molten salt reactors (MSRs), a fast-burst health physics reactor, and seven LWRs. Operation of the High Flux Isotope Reactor (HFIR) has been ongoing since 1965. Expertise exists amongst the ORNL staff to provide non-LWR training; support evaluation of non-LWR licensing and safety issues; perform modeling and simulation using advanced computational tools; run laboratory experiments usingmore » equipment such as the liquid salt component test facility; and perform in-depth fuel performance and thermal-hydraulic technology reviews using a vast suite of computer codes and tools. Summaries of this expertise are included in this paper.« less

As-built design specification for CAMS Development Dot Data System (CDDDS)

NASA Technical Reports Server (NTRS)

Wehmanen, O. A.

1979-01-01

The CAMS development dot data system is described. Listings and flow charts of the eight programs used to maintain the data base and the 15 subroutines used in FORTRAN programs to process the data are presented.

Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor

NASA Astrophysics Data System (ADS)

Jepsen, Morten Leth; Harmsen, Charlotte; Godbole, Adwait Anand; Nagaraja, Valakunja; Knudsen, Birgitta R.; Ho, Yi-Ping

2015-12-01

We present a quantum dot based DNA nanosensor specifically targeting the cleavage step in the reaction cycle of the essential DNA-modifying enzyme, mycobacterial topoisomerase I. The design takes advantages of the unique photophysical properties of quantum dots to generate visible fluorescence recovery upon specific cleavage by mycobacterial topoisomerase I. This report, for the first time, demonstrates the possibility to quantify the cleavage activity of the mycobacterial enzyme without the pre-processing sample purification or post-processing signal amplification. The cleavage induced signal response has also proven reliable in biological matrices, such as whole cell extracts prepared from Escherichia coli and human Caco-2 cells. It is expected that the assay may contribute to the clinical diagnostics of bacterial diseases, as well as the evaluation of treatment outcomes.We present a quantum dot based DNA nanosensor specifically targeting the cleavage step in the reaction cycle of the essential DNA-modifying enzyme, mycobacterial topoisomerase I. The design takes advantages of the unique photophysical properties of quantum dots to generate visible fluorescence recovery upon specific cleavage by mycobacterial topoisomerase I. This report, for the first time, demonstrates the possibility to quantify the cleavage activity of the mycobacterial enzyme without the pre-processing sample purification or post-processing signal amplification. The cleavage induced signal response has also proven reliable in biological matrices, such as whole cell extracts prepared from Escherichia coli and human Caco-2 cells. It is expected that the assay may contribute to the clinical diagnostics of bacterial diseases, as well as the evaluation of treatment outcomes. Electronic supplementary information (ESI) available: Characterization of the QD-based DNA Nanosensor. See DOI: 10.1039/c5nr06326d

[Louis Braille (1809-1852)--inventor of raised dots system].

PubMed

Maciejewicz, Piotr; Kopacz, Dorota

2005-01-01

Louis Braille was born on January 4th 1809 in Coupvray, France. An injury to his eye at the age of three, resulted in total loss of vision. In 1819 he entered the Institute for Blind Youth in Paris. There he would live, study, and later teach. When he was fifteen, he developed system of reading and writing by means of raised dots, which is known today as Braille. The basis of the Braille system is known as a Braille cell. The cell is comprised of six dots numbered in a specific order. Each dot or combination of dots represents a letter of the alphabet. This Braille system has established itself internationally and formed the basic Braille for all languages.

Arginine-glycine-aspartic acid-conjugated dendrimer-modified quantum dots for targeting and imaging melanoma.

PubMed

Li, Zhiming; Huang, Peng; Lin, Jing; He, Rong; Liu, Bing; Zhang, Xiaomin; Yang, Sen; Xi, Peng; Zhang, Xuejun; Ren, Qiushi; Cui, Daxiang

2010-08-01

Angiogenesis is essential for the development of malignant tumors and provides important targets for tumor diagnosis and therapy. Quantum dots have been broadly investigated for their potential application in cancer molecular imaging. In present work, CdSe quantum dots were synthesized, polyamidoamine dendrimers were used to modify surface of quantum dots and improve their solubility in water solution. Then, dendrimer-modified CdSe quantum dots were conjugated with arginine-glycine-aspartic acid (RGD) peptides. These prepared nanoprobes were injected into nude mice loaded with melanoma (A375) tumor xenografts via tail vessels, IVIS imaging system was used to image the targeting and bio-distribution of as-prepared nanoprobes. The dendrimer-modified quantum dots exhibit water-soluble, high quantum yield, and good biocompatibility. RGD-conjugated quantum dots can specifically target human umbilical vein endothelial cells (HUVEC) and A375 melanoma cells, as well as nude mice loaded with A735 melanoma cells. High-performance RGD-conjugated dendrimers modified quantum dot-based nanoprobes have great potential in application such as tumor diagnosis and therapy.

Carbon "Quantum" Dots for Fluorescence Labeling of Cells.

PubMed

Liu, Jia-Hui; Cao, Li; LeCroy, Gregory E; Wang, Ping; Meziani, Mohammed J; Dong, Yiyang; Liu, Yuanfang; Luo, Pengju G; Sun, Ya-Ping

2015-09-02

The specifically synthesized and selected carbon dots of relatively high fluorescence quantum yields were evaluated in their fluorescence labeling of cells. For the cancer cell lines, the cellular uptake of the carbon dots was generally efficient, resulting in the labeling of the cells with bright fluorescence emissions for both one- and two-photon excitations from predominantly the cell membrane and cytoplasm. In the exploration on labeling the live stem cells, the cellular uptake of the carbon dots was relatively less efficient, though fluorescence emissions could still be adequately detected in the labeled cells, with the emissions again predominantly from the cell membrane and cytoplasm. This combined with the observed more efficient internalization of the same carbon dots by the fixed stem cells might suggest some significant selectivity of the stem cells toward surface functionalities of the carbon dots. The needs and possible strategies for more systematic and comparative studies on the fluorescence labeling of different cells, including especially live stem cells, by carbon dots as a new class of brightly fluorescent probes are discussed.

Dot-Blot Immunoassay of Fasciola gigantica Infection using 27 kDa and Adult Worm Regurge Antigens in Egyptian Patients

PubMed Central

Kamel, Hanan H.; Saad, Ghada A.

2013-01-01

The purpose of the present study was to evaluate the potential role of the 27-Kilodalton (KDa) antigen versus Fasciola gigantica adult worm regurge antigens in a DOT-Blot assay and to assess this assay as a practical tool for diagnosis fascioliasis in Egyptian patients. Fasciola gigantica antigen of an approximate molecular mass 27-(KDa) was obtained from adult worms by a simple elution SDS-PAGE. A Dot-Blot was developed comparatively to adult worm regurge antigens for the detection of specific antibodies from patients infected with F. gigantica in Egypt. Control sera were obtained from patients with other parasitic infections and healthy volunteers to assess the test and compare between the antigens. The sensitivity, specificity, positive and negative predictive values of Dot-Blot using the adult worm regurge were 80%, 90%, 94.1%, and 69.2% respectively, while those using 27-KDa were 100% which confirms the diagnostic potential of this antigen. All patients infected with Fasciola were positive, with cross reactivity reported with Schistosoma mansoni serum samples. This 27-KDa Dot-Blot assay showed to be a promising test which can be used for serodiagnosis of fascioliasis in Egyptian patients especially, those presenting with hepatic disease. It is specific, sensitive and easy to perform method for the rapid diagnosis particularly when more complex laboratory tests are unavailable. PMID:23710084

Dot-blot immunoassay of Fasciola gigantica infection using 27 kDa and adult worm regurge antigens in Egyptian patients.

PubMed

Kamel, Hanan H; Saad, Ghada A; Sarhan, Rania M

2013-04-01

The purpose of the present study was to evaluate the potential role of the 27-Kilodalton (KDa) antigen versus Fasciola gigantica adult worm regurge antigens in a DOT-Blot assay and to assess this assay as a practical tool for diagnosis fascioliasis in Egyptian patients. Fasciola gigantica antigen of an approximate molecular mass 27-(KDa) was obtained from adult worms by a simple elution SDS-PAGE. A Dot-Blot was developed comparatively to adult worm regurge antigens for the detection of specific antibodies from patients infected with F. gigantica in Egypt. Control sera were obtained from patients with other parasitic infections and healthy volunteers to assess the test and compare between the antigens. The sensitivity, specificity, positive and negative predictive values of Dot-Blot using the adult worm regurge were 80%, 90%, 94.1%, and 69.2% respectively, while those using 27-KDa were 100% which confirms the diagnostic potential of this antigen. All patients infected with Fasciola were positive, with cross reactivity reported with Schistosoma mansoni serum samples. This 27-KDa Dot-Blot assay showed to be a promising test which can be used for serodiagnosis of fascioliasis in Egyptian patients especially, those presenting with hepatic disease. It is specific, sensitive and easy to perform method for the rapid diagnosis particularly when more complex laboratory tests are unavailable.

Conceptual Design and Neutronics Analyses of a Fusion Reactor Blanket Simulation Facility

DTIC Science & Technology

1986-01-01

Laboratory (LLL) ORNL Oak Ridge National Laboratory PPPL Princeton Plasma Physics Laboratory RSIC Reactor Shielding Information Center (at ORNL) SS...Module (LBM) to be placed in the TFTR at PPPL . Jassby et al. describe the program, including design, manufacturing techniques. neutronics analyses, and

The Legionella pneumophila PilT Homologue DotB Exhibits ATPase Activity That Is Critical for Intracellular Growth

PubMed Central

Sexton, Jessica A.; Pinkner, Jerome S.; Roth, Robyn; Heuser, John E.; Hultgren, Scott J.; Vogel, Joseph P.

2004-01-01

The ability of Legionella pneumophila to grow and cause disease in the host is completely dependent on a type IV secretion system known as the Dot/Icm complex. This membrane-spanning apparatus translocates effector molecules into host cells in a process that is poorly understood but that is known to require the putative ATPase DotB. One possible role for DotB is suggested by its similarity to the PilT family of proteins, which mediate pilus retraction. To better understand the molecular behavior of DotB, we have purified the protein and shown that it forms stable homohexameric rings and hydrolyzes ATP with a specific activity of 6.4 nmol of ATP/min/mg of protein. ATPase activity is critical to the function of DotB, as alteration of the conserved Walker box lysine residue resulted in a mutant protein, DotB K162Q, which failed to bind or hydrolyze ATP and which could not complement a ΔdotB strain for intracellular growth in macrophages. Consistent with the ability of DotB to interact with itself, the dotBK162Q allele exhibited transdominance over wild-type dotB, providing the first example of such a mutation in L. pneumophila. Finally, the DotB K162Q mutant protein had a significantly enhanced membrane localization in L. pneumophila compared to wild-type DotB, suggesting a relationship between nucleotide binding and membrane association. These results are consistent with a model in which DotB cycles between the cytoplasm and the Dot/Icm complex at the membrane, where it hydrolyzes nucleotides to provide energy to the complex. PMID:14996796

Pellet injector development at ORNL (Oak Ridge National Laboratory)

NASA Astrophysics Data System (ADS)

Gouge, M. J.; Argo, B. E.; Baylor, L. R.; Combs, S. K.; Fehling, D. T.; Fisher, P. W.; Foster, C. A.; Foust, C. R.; Milora, S. L.; Qualls, A. L.

1990-09-01

Advanced plasma fueling systems for magnetic confinement experiments are under development at Oak Ridge National Laboratory (ORNL). The general approach is that of producing and accelerating frozen hydrogenic pellets to speeds in the kilometer-per-second range by either pneumatic (light-gas gun) or mechanical (centrifugal force) techniques. ORNL has recently provided a centrifugal pellet injector for the Tore Supra tokamak and a new, simplified, eight-shot pneumatic injector for the Advanced Toroidal Facility stellarator at ORNL. Hundreds of tritium and DT pellets were accelerated at the Tritium Systems Test Assembly facility at Los Alamos in 1988 to 1989. These experiments, done in a single-shot pipe-gun system, demonstrated the feasibility of forming and accelerating tritium pellets at low (sup 3)He levels. A new, tritium-compatible extruder mechanism is being designed for longer-pulse DT applications. Two-stage light-gas guns and electron beam rocket accelerators for speeds of the order of 2 to 10 km/s are also under development. Recently, a repeating, two-stage light-gas gun accelerated 10 surrogate pellets at a 1-Hz repetition rate to speeds in the range of 2 to 3 km/s; and the electron beam rocket accelerator completed initial feasibility and scaling experiments. ORNL has also developed conceptual designs of advanced plasma fueling systems for the Compact Ignition Tokamak and the International Thermonuclear Experimental Reactor.

ORNL necessary and sufficient standards for environment, safety, and health. Final report of the Identification Team for other industrial, radiological, and non-radiological hazard facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-07-01

This Necessary and Sufficient (N and S) set of standards is for Other Industrial, Radiological, and Non-Radiological Hazard Facilities at Oak Ridge National Laboratory (ORNL). These facility classifications are based on a laboratory-wide approach to classify facilities by hazard category. An analysis of the hazards associated with the facilities at ORNL was conducted in 1993. To identify standards appropriate for these Other Industrial, Radiological, and Non-Radiological Hazard Facilities, the activities conducted in these facilities were assessed, and the hazards associated with the activities were identified. A preliminary hazards list was distributed to all ORNL organizations. The hazards identified in priormore » hazard analyses are contained in the list, and a category of other was provided in each general hazard area. A workshop to assist organizations in properly completing the list was held. Completed hazard screening lists were compiled for each ORNL division, and a master list was compiled for all Other Industrial, Radiological Hazard, and Non-Radiological facilities and activities. The master list was compared against the results of prior hazard analyses by research and development and environment, safety, and health personnel to ensure completeness. This list, which served as a basis for identifying applicable environment, safety, and health standards, appears in Appendix A.« less

Spatially selective assembly of quantum dot light emitters in an LED using engineered peptides.

PubMed

Demir, Hilmi Volkan; Seker, Urartu Ozgur Safak; Zengin, Gulis; Mutlugun, Evren; Sari, Emre; Tamerler, Candan; Sarikaya, Mehmet

2011-04-26

Semiconductor nanocrystal quantum dots are utilized in numerous applications in nano- and biotechnology. In device applications, where several different material components are involved, quantum dots typically need to be assembled at explicit locations for enhanced functionality. Conventional approaches cannot meet these requirements where assembly of nanocrystals is usually material-nonspecific, thereby limiting the control of their spatial distribution. Here we demonstrate directed self-assembly of quantum dot emitters at material-specific locations in a color-conversion LED containing several material components including a metal, a dielectric, and a semiconductor. We achieve a spatially selective immobilization of quantum dot emitters by using the unique material selectivity characteristics provided by the engineered solid-binding peptides as smart linkers. Peptide-decorated quantum dots exhibited several orders of magnitude higher photoluminescence compared to the control groups, thus, potentially opening up novel ways to advance these photonic platforms in applications ranging from chemical to biodetection.

As-built design specification for P1A software system modified display subsystem

NASA Technical Reports Server (NTRS)

Horton, C. L.; Story, A. S. (Principal Investigator)

1980-01-01

This document contains the design of the proportional estimate processor which was written to satisfy the software requirement of Part A of the P1A experiment. The purposes of the project are: (1) to select the dots to be labelled; (2) to create tables of green numbers and brightness values for all selected dots per acquisition; (3) to create scatter plots of green numbers vs brightness for each acquisition for all selected dots. If labels have been provided then scatter plots of only categories of interest can be optionally produced; and (4) to produce trajectory plots of green number vs brightness at differing acquisition times for each dot. These plots need to be in the same order as the list of selected dots. When labels are provided only plots of dots of categories of interest are to be produced.

Enabling Interoperability and Servicing Multiple User Segments Through Web Services, Standards, and Data Tools

NASA Astrophysics Data System (ADS)

Palanisamy, Giriprakash; Wilson, Bruce E.; Cook, Robert B.; Lenhardt, Chris W.; Santhana Vannan, Suresh; Pan, Jerry; McMurry, Ben F.; Devarakonda, Ranjeet

2010-12-01

The Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC) is one of the science-oriented data centers in EOSDIS, aligned primarily with terrestrial ecology. The ORNL DAAC archives and serves data from NASA-funded field campaigns (such as BOREAS, FIFE, and LBA), regional and global data sets relevant to biogeochemical cycles, land validation studies for remote sensing, and source code for some terrestrial ecology models. Users of the ORNL DAAC include field ecologists, remote sensing scientists, modelers at various scales, synthesis scientific groups, a range of educational users (particularly baccalaureate and graduate instruction), and decision support analysts. It is clear that the wide range of users served by the ORNL DAAC have differing needs and differing capabilities for accessing and using data. It is also not possible for the ORNL DAAC, or the other data centers in EDSS to develop all of the tools and interfaces to support even most of the potential uses of data directly. As is typical of Information Technology to support a research enterprise, the user needs will continue to evolve rapidly over time and users themselves cannot predict future needs, as those needs depend on the results of current investigation. The ORNL DAAC is addressing these needs by targeted implementation of web services and tools which can be consumed by other applications, so that a modeler can retrieve data in netCDF format with the Climate Forecasting convention and a field ecologist can retrieve subsets of that same data in a comma separated value format, suitable for use in Excel or R. Tools such as our MODIS Subsetting capability, the Spatial Data Access Tool (SDAT; based on OGC web services), and OPeNDAP-compliant servers such as THREDDS particularly enable such diverse means of access. We also seek interoperability of metadata, recognizing that terrestrial ecology is a field where there are a very large number of relevant data repositories. ORNL DAAC metadata is published to several metadata repositories using the Open Archive Initiative Protocol for Metadata Handling (OAI-PMH), to increase the chances that users can find data holdings relevant to their particular scientific problem. ORNL also seeks to leverage technology across these various data projects and encourage standardization of processes and technical architecture. This standardization is behind current efforts involving the use of Drupal and Fedora Commons. This poster describes the current and planned approaches that the ORNL DAAC is taking to enable cost-effective interoperability among data centers, both across the NASA EOSDIS data centers and across the international spectrum of terrestrial ecology-related data centers. The poster will highlight the standards that we are currently using across data formats, metadata formats, and data protocols. References: [1]Devarakonda R., et al. Mercury: reusable metadata management, data discovery and access system. Earth Science Informatics (2010), 3(1): 87-94. [2]Devarakonda R., et al. Data sharing and retrieval using OAI-PMH. Earth Science Informatics (2011), 4(1): 1-5.

Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis

PubMed Central

Wen, Luan; Fu, Liezhen; Guo, Xiaogang; Chen, Yonglong; Shi, Yun-Bo

2015-01-01

Histone methylations have been implicated to play important roles in diverse cellular processes. Of particular interest is the methylation of histone H3K79, which is catalyzed by an evolutionarily conserved methyltransferase, disruptor of telomeric silencing (Dot1)-like (Dot1L). To investigate the role of Dot1L during vertebrate development, we have generated a Dot1L-specific transcription activator-like effector nuclease (TALEN) nuclease to knockdown endogenous Dot1L in Xenopus tropicalis, a diploid species highly related to the well-known developmental model Xenopus laevis, a pseudotetraploid amphibian. We show that the TALEN was extremely efficient in mutating Dot1L when expressed in fertilized eggs, creating essentially Dot1L knockout embryos with little H3K79 methylation. Importantly, we observed that Dot1L knockdown had no apparent effect on embryogenesis because normally feeding tadpoles were formed, consistent with the lack of maternal Dot1L expression. On the other hand, Dot1L knockdown severely retarded the growth of the tadpoles and led to tadpole lethality prior to metamorphosis. These findings suggest that Dot1L and H3K79 methylation play an important role for tadpole growth and development prior to metamorphosis into a frog. Our findings further reveal interesting similarities and differences between Xenopus and mouse development and suggest the existence of 2 separate phases of vertebrate development with distinct requirements for epigenetic modifications.—Wen, L., Fu, L., Guo, X., Chen, Y., Shi, Y.-B. Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis. PMID:25366346

Effects of Cycling vs. Running Training on Endurance Performance in Preparation for Inline Speed Skating.

PubMed

Stangier, Carolin; Abel, Thomas; Hesse, Clemens; Claen, Stephanie; Mierau, Julia; Hollmann, Wildor; Strüder, Heiko K

2016-06-01

Winter weather conditions restrict regular sport-specific endurance training in inline speed skating. As a result, this study was designed to compare the effects of cycling and running training programs on inline speed skaters' endurance performance. Sixteen (8 men, 8 women) high-level athletes (mean ± SD 24 ± 8 years) were randomly assigned to 1 of 2 groups (running and cycling). Both groups trained twice a week for 8 weeks, one group on a treadmill and the other on a cycle ergometer. Training intensity and duration was individually calculated (maximal fat oxidation: ∼52% of V[Combining Dot Above]O2peak: 500 kcal per session). Before and after the training intervention, all athletes performed an incremental specific (inline speed skating) and 1 nonspecific (cycling or running) step test according to the group affiliation. In addition to blood lactate concentration, oxygen uptake (V[Combining Dot Above]O2), ventilatory equivalent (VE/V[Combining Dot Above]O2), respiratory exchange ratio (RER), and heart rate were measured. The specific posttest revealed significantly increased absolute V[Combining Dot Above]O2peak values (2.9 ± 0.4, 3.4 ± 0.7, p = 0.01) and submaximal V[Combining Dot Above]O2 values (p ≤ 0.01). VE/V[Combining Dot Above]O2 and RER significantly decreased at maximal (46.6 ± 6.6, 38.5 ± 3.4, p = 0.005; 1.1 ± 0.03, 1.0 ± 0.04, p = 0.001) and submaximal intensities (p ≤ 0.04). None of the analysis revealed a significant group effect (p ≥ 0.15). The results indicate that both cycling vs. running exercise at ∼52% of V[Combining Dot Above]O2peak had a positive effect on the athletes' endurance performance. The increased submaximal V[Combining Dot Above]O2 values indicate a reduction in athletes' inline speed skating technique. Therefore, athletes would benefit from a focus on technique training in the subsequent period.

49 CFR 41.119 - DOT regulated buildings.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Each DOT Operating Administration with responsibility for regulating the structural safety of buildings... section pertains to all new building projects for which development of detailed plans and specifications... regulating the structural safety must comply with the seismic design and construction standards in this part...

MoDOT pavement preservation research program volume V, site-specific pavement condition assessment.

DOT National Transportation Integrated Search

2015-11-01

The overall objective of Task 4 was to thoroughly assess the cost-effectiveness and utility of selected non-invasive technologies as : applicable to MoDOT roadways. Non-invasive imaging technologies investigated in this project were Ultrasonic Surfac...

Fire tests to evaluate the potential fire threat and its effects on HEPA filter integrity in cell ventilation at the Oak Ridge National Laboratory, Building 7920

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hasegawa, H.K.; Staggs, K.J.; Doughty, S.M.

1992-12-01

As a result of a DOE (Tiger Team) Technical Safety Appraisal (November 1990) of the Radiochemical Engineering Development Center (REDC), ORNL Building 7920, a number of fire protection concerns were identified. The primary concern was the perceived loss of ventilation system containment due to the thermal destruction and/or breaching of the prefilters and/or high-efficiency particulate air filters (HEPA `s) and the resultant radioactive release to the external environment. The following report describes the results of an extensive fire test program performed by the Fire Research Discipline (FRD) of the Special Projects Division of Lawrence Livermore National Lab (LLNL) and fundedmore » by ORNL to address these concerns. Full scale mock-ups of a REDC hot cell tank pit, adjacent cubicle pit, and associated ventilation system were constructed at LLNL and 13 fire experiments were conducted to specifically answer the questions raised by the Tiger Team. Our primary test plan was to characterize the burning of a catastrophic solvent spill (kerosene) of 40 liters and its effect on the containment ventilation system prefilters and HEPA filters. In conjunction with ORNL and Lockwood Greene we developed a test matrix that assessed the fire performance of the prefilters and HEPA filters; evaluated the fire response of the fiber reinforced plastic (FRP) epoxy ventilation duct work; the response and effectiveness of the fire protection system, the effect of fire in a cubicle on the vessel off-gas (VOG) elbow, and other fire safety questions.« less

Best Practices for NPT Transit Matching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gilligan, Kimberly V.; Whitaker, J. Michael; Oakberg, John A.

2016-09-01

Transit matching is the process for relating or matching reports of shipments and receipts submitted to the International Atomic Energy Agency (IAEA). Transit matching is a component used by the IAEA in drawing safeguards conclusions and performing investigative analysis. Transit matching is part of IAEA safeguards activities and the State evaluation process, and it is included in the annual Safeguards Implementation Report (SIR). Annually, the IAEA currently receives reports of ~900,000 nuclear material transactions, of which ~500,000 are for domestic and foreign transfers. Of these the IAEA software can automatically match (i.e., machine match) about 95% of the domestic transfersmore » and 25% of the foreign transfers. Given the increasing demands upon IAEA resources, it is highly desirable for the machine-matching process to match as many transfers as possible. Researchers at Oak Ridge National Laboratory (ORNL) have conducted an investigation funded by the National Nuclear Security Administration through the Next Generation Safeguards Initiative to identify opportunities to strengthen IAEA transit matching. Successful matching, and more specifically machine matching, is contingent on quality data from the reporting States. In February 2016, ORNL hosted representatives from three States, the IAEA, and Euratom to share results from past studies and to discuss the processes, policies, and procedures associated with State reporting for transit matching. Drawing on each entity's experience and knowledge, ORNL developed a best practices document to be shared with the international safeguards community to strengthen transit matching. This paper shares the recommendations that resulted from this strategic meeting and the next steps being taken to strengthen transit matching.« less

Braking reaching movements: a test of the constant tau-dot strategy under different viewing conditions.

PubMed

Hopkins, Brian; Churchill, Andrew; Vogt, Stefan; Rönnqvist, Louise

2004-03-01

Following F. Zaal and R. J. Bootsma (1995), the authors studied whether the decelerative phase of a reaching movement could be modeled as a constant tau-dot strategy resulting in a soft collision with the object. Specifically, they investigated whether that strategy is sustained over different viewing conditions. Participants (N = 11) were required to reach for 15- and 50-mm objects at 2 different distances under 3 conditions in which visual availability of the immediate environment and of the reaching hand were varied. Tau-dot estimates and goodness-of-fit were highly similar across the 3 conditions. Only within-participant variability of tau-dot estimates was increased when environmental cues were removed. That finding suggests that the motor system uses a tau-dot strategy involving the intermodal (i.e., visual, proprioceptive, or both) specification of information to regulate the decelerative phase of reaching under restricted viewing conditions. The authors provide recommendations for improving the derivation of tau;(x) estimates and stress the need for further research on how time-to-contact information is used in the regulation of the dynamics of actions such as reaching.

Development of a rapid diagnostic test for pertussis: direct detection of pertussis toxin in respiratory secretions.

PubMed Central

Friedman, R L; Paulaitis, S; McMillan, J W

1989-01-01

Monoclonal antibodies (MAb) were produced against the specific Bordetella pertussis antigen pertussis toxin (PT). In preliminary studies, one MAb (IB12) was selected and used in an enzyme-linked dot blot immunoassay to evaluate the ability of the method to detect known amounts of PT in control experiments and to test its potential for direct detection of PT in nasopharyngeal secretion (NP) specimens from patients with confirmed cases of whooping cough. The dot blot assay was able to detect PT at levels as low as 10 ng per dot in either buffer or control NP specimens. The assay demonstrated specificity, reacting only with dot blots of whole B. pertussis and not Bordetella bronchiseptica, Bordetella parapertussis, or other bacterial strains. In preliminary studies, NP aspirate, swab, and wash specimens were compared. The specimen of choice was found to be the NP aspirate, for which 100% positive results were found in the assay. These initial studies suggest that the dot blot immunoassay in which a MAb is used for direct detection of PT in NP specimens may be useful as a rapid diagnostic test for pertussis. Images PMID:2808670

Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.

PubMed

Varghese, Anju; Raina, O K; Nagar, Gaurav; Garg, Rajat; Banerjee, P S; Maharana, B R; Kollannur, Justin D

2012-02-10

Native cathepsin-L cysteine proteinase (28 kDa) was purified from the excretory secretory products of Fasciola gigantica and was used for sero-diagnosis of F. gigantica infection in buffaloes by Dot-enzyme-linked immunosorbent assay (Dot-ELISA). The test detected F. gigantica field infection in these animals with a sensitivity of ∼ 90%. No specific IgG antibody binding was displayed by sera obtained from 76 buffaloes considered to be Fasciola and other parasite-free by microscopic examination of faeces and necropsy examination of liver, rumen and intestine. Additionally, sera from 156 Fasciola-free buffaloes, yet infected with Gigantocotyle explanatum, Paramphistomum epiclitum, Gastrothylax spp., Strongyloides papillosus and hydatid cyst were all negative, indicating that F. gigantica cathepsin-L cysteine proteinase does not cross-react with these helminth parasites in natural infection of the host. The data indicated that cathepsin-L cysteine proteinase based Dot-ELISA reached ∼ 90% sensitivity and 100% specificity with relation to above parasites in the detection of bubaline fasciolosis. The present Dot-ELISA diagnostic assay is relevant to the field diagnosis of F. gigantica infection in buffaloes. Copyright © 2011 Elsevier B.V. All rights reserved.

Specific features of electroluminescence in heterostructures with InSb quantum dots in an InAs matrix

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parkhomenko, Ya. A.; Ivanov, E. V.; Moiseev, K. D., E-mail: mkd@iropt2.ioffe.rssi.ru

2013-11-15

The electrical and electroluminescence properties of a single narrow-gap heterostructure based on a p-n junction in indium arsenide, containing a single layer of InSb quantum dots in the InAs matrix, are studied. The presence of quantum dots has a significant effect on the shape of the reverse branch of the current-voltage characteristic of the heterostructure. Under reverse bias, the room-temperature electroluminescence spectra of the heterostructure with quantum dots, in addition to a negative-luminescence band with a maximum at the wavelength {lambda} = 3.5 {mu}m, contained a positive-luminescence emission band at 3.8 {mu}m, caused by radiative transitions involving localized states ofmore » quantum dots at the type-II InSb/InAs heterointerface.« less

Application of photostable quantum dots for indirect immunofluorescent detection of specific bacterial serotypes on small marine animals

NASA Astrophysics Data System (ADS)

Decho, Alan W.; Beckman, Erin M.; Chandler, G. Thomas; Kawaguchi, Tomohiro

2008-06-01

An indirect immunofluorescence approach was developed using semiconductor quantum dot nanocrystals to label and detect a specific bacterial serotype of the bacterial human pathogen Vibrio parahaemolyticus, attached to small marine animals (i.e. benthic harpacticoid copepods), which are suspected pathogen carriers. This photostable labeling method using nanotechnology will potentially allow specific serotypes of other bacterial pathogens to be detected with high sensitivity in a range of systems, and can be easily applied for sensitive detection to other Vibrio species such as Vibrio cholerae.

Flood analyses for Department of Energy Y-12, ORNL and K-25 Plants. Flood analyses in support of flood emergency planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-05-01

The study involved defining the flood potential and local rainfall depth and duration data for the Department of Energy`s (DOE) Y-12, Oak Ridge National Laboratory (ORNL), and K-25 plants. All three plants are subject to flooding from the Clinch River. In addition, the Y-12 plant is subject to flooding from East Fork Poplar and Bear Creeks, the ORNL plant from Whiteoak Creek and Melton Branch, and the K-25 plant from Poplar Creek. Determination of flood levels included consideration of both rainfall events and postulated failures of Norris and Melton Hill Dams in seismic events.

ORNL-TNS/PEPR overall heating requirements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Y. K.M.; Rome, J. A.

1977-01-01

The ORNL TNS/PEPR studies have the objectives of (1) leading to a system that demonstrates the fusion reactor core in the mid-to-late 1980's and extrapolates to an economic tokamak power reactor, and (2) providing a near-term focus for the scientific and technological programs toward the power reactor. This discussion of the overall heating requirements for the ORNL TNS/PEPR is concerned with the neutral beams as the primary heating method, the electron-cyclotron resonance (ECR) heating at a lower power level for profile control, and the upper hybrid resonance (UHR) initiation and preheating of currentless plasmas to reduce current start-up loop voltagemore » (V/sub l/) requirements.« less

Electronic Structure and Transport in Magnetic Multilayers

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2008-02-18

ORNL assisted Seagate Recording Heads Operations in the development of CIPS pin Valves for application as read sensors in hard disk drives. Personnel at ORNL were W. H. Butler and Xiaoguang Zhang. Dr. Olle Heinonen from Seagate RHO also participated. ORNL provided codes and materials parameters that were used by Seagate to model CIP GMR in their heads. The objectives were to: (1) develop a linearized Boltzmann transport code for describing CIP GMR based on realistic models of the band structure and interfaces in materials in CIP spin valves in disk drive heads; (2) calculate the materials parameters needed asmore » inputs to the Boltzmann code; and (3) transfer the technology to Seagate Recording Heads.« less

Assessing IRI vs. PI as a measurement of pavement smoothness : final report, June 2006.

DOT National Transportation Integrated Search

2006-06-07

A Pavement smoothness specification that allows either the International Roughness Index (IRI) or Profile Index (PI) to measure pavement smoothness would be advantageous to both industry and MoDOT. This brief study provides for MoDOT an understanding...

14 CFR 302.11 - Motions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... otherwise specifically provided for in this part shall be by motion. If an administrative law judge is... of the record to the DOT decisionmaker, all motions shall be addressed to the administrative law... heard on motions unless the DOT decisionmaker or the administrative law judge otherwise directs. Written...

14 CFR 302.11 - Motions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... otherwise specifically provided for in this part shall be by motion. If an administrative law judge is... of the record to the DOT decisionmaker, all motions shall be addressed to the administrative law... heard on motions unless the DOT decisionmaker or the administrative law judge otherwise directs. Written...

14 CFR 302.11 - Motions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... otherwise specifically provided for in this part shall be by motion. If an administrative law judge is... of the record to the DOT decisionmaker, all motions shall be addressed to the administrative law... heard on motions unless the DOT decisionmaker or the administrative law judge otherwise directs. Written...

Expression of the Tpanxb1 gene from Taenia pisiformis and its potential diagnostic value by dot-ELISA.

PubMed

Yang, Deying; Chen, Lin; Wu, Xuhang; Zhou, Xuan; Li, Mei; Chen, Zuqin; Nong, Xiang; Gu, Xiaobin; Peng, Xuerong; Yang, Guangyou

2014-04-01

Cysticercosis, caused by the larvae of Taenia pisiformis, is a common disease in rabbits that results in economic losses. To date, there has been limited information available on the early detection of infection by this parasite. This study describes a dot-ELISA method based on an autologous antigen annexin B1 (Tpanxb1). Its potential for serodiagnosis of rabbit cysticercosis was also evaluated. Western blot analysis revealed that the recombinant Tpanxb1 (rTpanxb1) protein could be specifically recognized by rabbit anti-sera. In serum trials, the antibodies could be detected by dot-ELISA using rTpanxb1 at 14 days post-infection. The positive response was present for up to 49 days post-infection. Based on the necropsy results of 169 rabbit samples, the relative sensitivity and specificity of the dot-ELISA were 94.55% and 92.86%, respectively. This study provides a foundation for studying the immunological function of annexin and its application to control Taenia cestodes.

FABRICATION AND DEPLOYMENT OF THE 9979 TYPE AF RADIOACTIVE WASTE PACKAGING FOR THE DEPARTMENT OF ENERGY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blanton, P.; Eberl, K.

2013-10-10

This paper summarizes the development, testing, and certification of the 9979 Type A Fissile Packaging that replaces the UN1A2 Specification Shipping Package eliminated from Department of Transportation (DOT) 49 CFR 173. The DOT Specification Package was used for many decades by the U.S. nuclear industry as a fissile waste container until its removal as an authorized container by DOT. This paper will discuss stream lining procurement of high volume radioactive material packaging manufacturing, such as the 9979, to minimize packaging production costs without sacrificing Quality Assurance. The authorized content envelope (combustible and non-combustible) as well as planned content envelope expansionmore » will be discussed.« less

DOT1L regulates dystrophin expression and is critical for cardiac function

PubMed Central

Nguyen, Anh T.; Xiao, Bin; Neppl, Ronald L.; Kallin, Eric M.; Li, Juan; Chen, Taiping; Wang, Da-Zhi; Xiao, Xiao; Zhang, Yi

2011-01-01

Histone methylation plays an important role in regulating gene expression. One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L. Previous studies have demonstrated that germline disruption of Dot1L in mice resulted in embryonic lethality. Here we report that cardiac-specific knockout of Dot1L results in increased mortality rate with chamber dilation, increased cardiomyocyte cell death, systolic dysfunction, and conduction abnormalities. These phenotypes mimic those exhibited in patients with dilated cardiomyopathy (DCM). Mechanistic studies reveal that DOT1L performs its function in cardiomyocytes through regulating Dystrophin (Dmd) transcription and, consequently, stability of the Dystrophin–glycoprotein complex important for cardiomyocyte viability. Importantly, expression of a miniDmd can largely rescue the DCM phenotypes, indicating that Dmd is a major target mediating DOT1L function in cardiomyocytes. Interestingly, analysis of available gene expression data sets indicates that DOT1L is down-regulated in idiopathic DCM patient samples compared with normal controls. Therefore, our study not only establishes a critical role for DOT1L-mediated H3K79 methylation in cardiomyocyte function, but also reveals the mechanism underlying the role of DOT1L in DCM. In addition, our study may open new avenues for the diagnosis and treatment of human heart disease. PMID:21289070

ORNL Annual Sustainability Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lapsa, Melissa Voss; Nichols, Teresa A.

2014-02-01

As described in this report, we have made substantial progress across the 25 roadmaps of the Sustainable Campus Initiative. The report also outlines our plans to continue integrating sustainable practices into the planning, execution, and evaluation of all ORNL activities. We appreciate your interest in our journey to sustainability, and we welcome your comments, questions, and suggestions.

ORNL Lightweighting Research Featured on MotorWeek

ScienceCinema

None

2018-06-06

PBS MotorWeek, television's longest running automotive series, featured ORNL lightweighting research for vehicle applications in an episode that aired in early April 2014. The crew captured footage of research including development of new metal alloys, additive manufacturing, carbon fiber production, advanced batteries, power electronics components, and neutron imaging applications for materials evaluation.

Complete braided adsorbent for marine testing to demonstrate 3g-U/kg-adsorbent

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janke, Chris; Yatsandra, Oyola; Mayes, Richard

ORNL has manufactured four braided adsorbents that successfully demonstrated uranium adsorption capacities ranging from 3.0-3.6 g-U/kg-adsorbent in marine testing at PNNL. Four new braided and leno woven fabric adsorbents have also been prepared by ORNL and are currently undergoing marine testing at PNNL.

Remedial site evaluation report for the waste area grouping 10 wells associated with the new hydrofracture facility at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1: Evaluation, interpretation, and data summary

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-08-01

The Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is operated for the U.S. Department of Energy (DOE) by Lockheed Martin Energy System (Energy Systems). ORNL has pioneered waste disposal technologies since World War II as part of its DOE mission. In the late 1950s, at the request of the National Academy of Sciences, efforts were made to develop a permanent disposal alternative to the surface and tanks at ORNL. One such technology, the hydrofracture process, involved inducing fractures in a geologic host formation (a low-permeability shale) at depths of up to 1100 ft and injecting a radioactive groutmore » slurry containing low-level liquid or tank sludge waste, cement, and other additives at an injection pressure of 2000 to 8500 psi. The objective of the effort was to develop a grout dig could be injected as a slurry and would solidify after injection, thereby entombing the radioisotopes contained in the low-level liquid or tank sludge waste. Four sites at ORNL were used: two experimental (HF-1 and HF-2); one developmental, later converted to batch process [Old Hydrofracture Facility (BF-3)]; and one production facility [New Hydrofracture Facility (BF-4)]. This document provides the environmental, restoration program with information about the the results of an evaluation of WAG 10 wells associated with the New Hydrofracture Facility at ORNL.« less

A Transfer Hamiltonian Model for Devices Based on Quantum Dot Arrays

PubMed Central

Illera, S.; Prades, J. D.; Cirera, A.; Cornet, A.

2015-01-01

We present a model of electron transport through a random distribution of interacting quantum dots embedded in a dielectric matrix to simulate realistic devices. The method underlying the model depends only on fundamental parameters of the system and it is based on the Transfer Hamiltonian approach. A set of noncoherent rate equations can be written and the interaction between the quantum dots and between the quantum dots and the electrodes is introduced by transition rates and capacitive couplings. A realistic modelization of the capacitive couplings, the transmission coefficients, the electron/hole tunneling currents, and the density of states of each quantum dot have been taken into account. The effects of the local potential are computed within the self-consistent field regime. While the description of the theoretical framework is kept as general as possible, two specific prototypical devices, an arbitrary array of quantum dots embedded in a matrix insulator and a transistor device based on quantum dots, are used to illustrate the kind of unique insight that numerical simulations based on the theory are able to provide. PMID:25879055

A transfer hamiltonian model for devices based on quantum dot arrays.

PubMed

Illera, S; Prades, J D; Cirera, A; Cornet, A

2015-01-01

We present a model of electron transport through a random distribution of interacting quantum dots embedded in a dielectric matrix to simulate realistic devices. The method underlying the model depends only on fundamental parameters of the system and it is based on the Transfer Hamiltonian approach. A set of noncoherent rate equations can be written and the interaction between the quantum dots and between the quantum dots and the electrodes is introduced by transition rates and capacitive couplings. A realistic modelization of the capacitive couplings, the transmission coefficients, the electron/hole tunneling currents, and the density of states of each quantum dot have been taken into account. The effects of the local potential are computed within the self-consistent field regime. While the description of the theoretical framework is kept as general as possible, two specific prototypical devices, an arbitrary array of quantum dots embedded in a matrix insulator and a transistor device based on quantum dots, are used to illustrate the kind of unique insight that numerical simulations based on the theory are able to provide.

Oak Ridge National Laboratory Waste Management Plan, fiscal year 1994. Revision 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Turner, J.W.

1993-12-01

US Department of Energy (DOE) Order 5820.2A was promulgated in final form on September 26, 1988. The order requires heads of field organizations to prepare and to submit updates on the waste management plans for all operations under their purview according to the format in Chap. 6, {open_quotes}Waste Management Plan Outline.{close_quotes} These plans are to be submitted by the DOE Oak Ridge Operations Office (DOE-ORO) in December of each year and distributed to the DP-12, ES&H-1, and other appropriate DOE Headquarters (DOE-HQ) organizations for review and comment. This document was prepared in response to this requirement for fiscal year (FY)more » 1994. The Oak Ridge National Laboratory (ORNL) waste management mission is reduction, collection, storage, treatment, and disposal of DOE wastes, generated primarily in pursuit of ORNL missions, in order to protect human health and safety and the environment. In carrying out this mission, waste management staff in the Waste Management and Remedial Action Division (WMRAD) will (1) guide ORNL in optimizing waste reduction and waste management capabilities and (2) conduct waste management operations in a compliant, publicly acceptable, technically sound, and cost-efficient manner. Waste management requirements for DOE radioactive wastes are detailed in DOE Order 5820.2A, and the ORNL Waste Management Program encompasses all elements of this order. The requirements of this DOE order and other appropriate DOE orders, along with applicable Tennessee Department of Environment and Conservation and US Environmental Protection Agency (EPA) rules and regulations, provide the principal source of regulatory guidance for waste management operations at ORNL. The objective of this document is compilation and consolidation of information on how the ORNL Waste Management Program is conducted, which waste management facilities are being used to manage wastes, what activities are planned for FY 1994, and how all of the activities are documented.« less

Evaluation of Aqua-Ammonia Chiller Technologies and Field Site Installation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zaltash, Abdolreza

2007-09-01

The Naval Facilities Engineering Service Center (NFESC) has sponsored Oak Ridge National Laboratory (ORNL) to review, select, and evaluate advanced, gas-fired, 5-ton, aqua-ammonia, chiller technologies. The selection criteria was that units have COP values of 0.67 or better at Air-conditioning and Refrigeration Institute (ARI) 95 F outdoor rating conditions, an active refrigerant flow control, and a variable-speed condenser fan. These features are expected to allow these units to operate at higher ambient temperatures (up to the maximum operating temperature of 110 F) with minimal degradation in performance. ORNL evaluated three potential manufacturers of advanced, gas-fired, 5-ton, aqua-ammonia chillers-Robur, Ambian, andmore » Cooling Technologies. Unfortunately, Robur did not meet the COP requirements and Cooling Technologies could not deliver a unit to be tested at the U.S. Department of Energy (DOE)-ORNL environmental chamber testing facility for thermally activated heat pumps. This eliminated these two technologies from further consideration, leaving only the Ambian chillers for evaluation. Two Ambian chillers were evaluated at the DOE-ORNL test facility. Overall these chillers operated well over a wide range of ambient conditions with minimal degradation in performance due to several control strategies used such as a variable speed condenser fan, a modulating burner, and active refrigerant flow control. These Ambian pre-commercial units were selected for installation and field testing at three federal facilities. NFESC worked with ORNL to assist with the site selection for installation and evaluation of these chillers. Two sites (ORNL and Naval Surface Warfare Center [NSWC] Corona) had a single chiller unit installed; and at one site (Naval Amphibious Base [NAB] Little Creek), two 5-ton chillers linked together were installed to provide 10 tons of cooling. A chiller link controller developed under this project was evaluated in the field test at Little Creek.« less

CdSe/ZnS Quantum Dot-Labeled Lateral Flow Strips for Rapid and Quantitative Detection of Gastric Cancer Carbohydrate Antigen 72-4

NASA Astrophysics Data System (ADS)

Yan, Xinyu; Wang, Kan; Lu, Wenting; Qin, Weijian; Cui, Daxiang; He, Jinghua

2016-03-01

Carbohydrate antigen 72-4 (CA72-4) is an important biomarker associated closely with diagnosis and prognosis of early gastric cancer. How to realize quick, sensitive, specific, and quantitative detection of CA72-4 in clinical specimens has become a great requirement. Herein, we reported a CdSe/ZnS quantum dot-labeled lateral flow test strip combined with a charge-coupled device (CCD)-based reader was developed for rapid, sensitive, and quantitative detection of CA72-4. Two mouse monoclonal antibodies (mAbs) against CA72-4 were employed. One of them was coated as a test line, while another mAb was labeled with quantum dots and coated onto conjugate pad. The goat anti-mouse IgG was immobilized as a control line. After sample was added, a sandwich structure was formed with CA72-4 and these two mAbs. The fluorescent signal from quantum dots (QD)-labeled mAb in sandwich structure was related to the amount of detected CA72-4. A CCD-based reader was used to realize quantitative detection of CA72-4. Results showed that developed QD-labeled lateral flow strips to detect CA72-4 biomarker with the sensitivity of 2 IU/mL and 10 min detection time. One hundred sera samples from clinical patients with gastric cancer and healthy people were used to confirm specificity of this strip method; results showed that established strip method own 100 % reproducibility and 100 % specificity compared with Roche electrochemiluminescence assay results. In conclusion, CdSe/ZnS quantum dot-labeled lateral flow strips for detection of CA72-4 could realize rapid, sensitive, and specific detection of clinical samples and could own great potential in clinical translation in near future.

Improving lab compaction specifications for flexible bases within the Texas DOT.

DOT National Transportation Integrated Search

2009-04-01

In Test Methods Tex-113-E and Tex-114-E, the Texas Department of Transportation (TxDOT) employs an impact hammer method of sample compaction for laboratory preparation of road base and subgrade materials for testing. In this third and final report do...

Quantum Dots for Molecular Pathology

PubMed Central

True, Lawrence D.; Gao, Xiaohu

2007-01-01

Assessing malignant tumors for expression of multiple biomarkers provides data that are critical for patient management. Quantum dot-conjugated probes to specific biomarkers are powerful tools that can be applied in a multiplex manner to single tissue sections of biopsies to measure expression levels of multiple biomarkers. PMID:17251330

Refinement of current WisDOT HMA mixture application guidelines related to NMAS and aggregate characteristics.

DOT National Transportation Integrated Search

2014-01-01

Current Wisconsin Department of Transportation (WisDOT) Specifications limit nominal maximum aggregate : size (NMAS) of hot-mix asphalt (HMA) to 12.5 mm in the surface layer and 19.0 mm in lower layers. This : potentially places unnecessary limits on...

Self-assembling complexes of quantum dots and scFv antibodies for cancer cell targeting and imaging.

PubMed

Zdobnova, Tatiana A; Stremovskiy, Oleg A; Lebedenko, Ekaterina N; Deyev, Sergey M

2012-01-01

Semiconductor quantum dots represent a novel class of fluorophores with unique physical and chemical properties which could enable a remarkable broadening of the current applications of fluorescent imaging and optical diagnostics. Complexes of quantum dots and antibodies are promising visualising agents for fluorescent detection of selective biomarkers overexpressed in tumor tissues. Here we describe the construction of self-assembling fluorescent complexes of quantum dots and anti-HER1 or anti-HER2/neu scFv antibodies and their interactions with cultured tumor cells. A binding strategy based on a very specific non-covalent interaction between two proteins, barnase and barstar, was used to connect quantum dots and the targeting antibodies. Such a strategy allows combining the targeting and visualization functions simply by varying the corresponding modules of the fluorescent complex.

Self-Assembling Complexes of Quantum Dots and scFv Antibodies for Cancer Cell Targeting and Imaging

PubMed Central

Zdobnova, Tatiana A.; Stremovskiy, Oleg A.; Lebedenko, Ekaterina N.; Deyev, Sergey M.

2012-01-01

Semiconductor quantum dots represent a novel class of fluorophores with unique physical and chemical properties which could enable a remarkable broadening of the current applications of fluorescent imaging and optical diagnostics. Complexes of quantum dots and antibodies are promising visualising agents for fluorescent detection of selective biomarkers overexpressed in tumor tissues. Here we describe the construction of self-assembling fluorescent complexes of quantum dots and anti-HER1 or anti-HER2/neu scFv antibodies and their interactions with cultured tumor cells. A binding strategy based on a very specific non-covalent interaction between two proteins, barnase and barstar, was used to connect quantum dots and the targeting antibodies. Such a strategy allows combining the targeting and visualization functions simply by varying the corresponding modules of the fluorescent complex. PMID:23133578

The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates

PubMed Central

Sutherland, Molly C.; Nguyen, Thuy Linh; Tseng, Victor; Vogel, Joseph P.

2012-01-01

Legionella pneumophila is a Gram-negative bacterium that replicates within human alveolar macrophages by evasion of the host endocytic pathway through the formation of a replicative vacuole. Generation of this vacuole is dependent upon the secretion of over 275 effector proteins into the host cell via the Dot/Icm type IVB secretion system (T4SS). The type IV coupling protein (T4CP) subcomplex, consisting of DotL, DotM, DotN, IcmS and IcmW, was recently defined. DotL is proposed to be the T4CP of the L. pneumophila T4SS based on its homology to known T4CPs, which function as inner-membrane receptors for substrates. As a result, DotL is hypothesized to play an integral role(s) in the L. pneumophila T4SS for the engagement and translocation of substrates. To elucidate this role, a genetic approach was taken to screen for dotL mutants that were unable to survive inside host cells. One mutant, dotLY725Stop, did not interact with the type IV adaptor proteins IcmS/IcmW (IcmSW) leading to the identification of an IcmSW-binding domain on DotL. Interestingly, the dotLY725Stop mutant was competent for export of one class of secreted effectors, the IcmSW-independent substrates, but exhibited a specific defect in secretion of IcmSW-dependent substrates. This differential secretion illustrates that DotL requires a direct interaction with the type IV adaptor proteins for the secretion of a major class of substrates. Thus, by identifying a new target for IcmSW, we have discovered that the type IV adaptors perform an additional role in the export of substrates by the L. pneumophila Dot/Icm T4SS. PMID:23028312

Testing of the 3M Company Composite Conductor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stovall, John P; Rizy, D Tom; Kisner, Roger A

2010-10-01

The 3M Company has developed a high-temperature low-sag conductor referred to as Aluminum-Conductor Composite-Reinforced or ACCR. The conductor uses an aluminum metal matrix material to replace the steel in conventional conductors. The objective of this work is to accelerate the commercial acceptance by electric utilities of this new conductor design by testing four representative conductor classes in controlled conditions. A unique facility called the Powerline Conductor Accelerated Testing (PCAT) Facility was built at ORNL for testing overhead conductors. The PCAT has been uniquely designed for testing overhead bare transmission line conductors at high currents and temperatures after they have beenmore » installed and tensioned to the manufacturer's specifications. The ability to operate a transmission line conductor in this manner does not exist elsewhere in the United States. Four classes of ACCR cable designed by the 3M Company have been successfully test at ORNL small, medium, large and small/compact. Based on these and other manufacturer tests, the 3M Company has successfully introduced the ACCR into the commercial market and has completed over twenty installations for utility companies.« less

Data Quality Assurance and Control for AmeriFlux Network at CDIAC, ORNL

NASA Astrophysics Data System (ADS)

Shem, W.; Boden, T.; Krassovski, M.; Yang, B.

2014-12-01

The Carbon Dioxide Information Analysis Center (CDIAC) at the Oak Ridge National Laboratory (ORNL) serves as the long-term data repository for the AmeriFlux network. Datasets currently available include hourly or half-hourly meteorological and flux observations, biological measurement records, and synthesis data products. Currently there is a lack of standardized nomenclature and specifically designed procedures for data quality assurance/control in processing and handling micrometeorological and ecological data at individual flux sites. CDIAC's has bridged this gap by providing efficient and accurate procedures for data quality control and standardization of the results for easier assimilation by the models used in climate science. In this presentation we highlight the procedures we have put in place to scrutinize continuous flux and meteorological data within Ameriflux network. We itemize some basic data quality issues that we have observed over the past years and include some examples of typical data quality issues. Such issues, e.g., incorrect time-stamping, poor calibration or maintenance of instruments, missing or incomplete metadata and others that are commonly over-looked by PI's, invariably impact the time-series observations.

Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination.

PubMed

Ji, Hanxu; Zhou, Feng; Gu, Jiangjiang; Shu, Chen; Xi, Kai; Jia, Xudong

2016-05-04

Nitrogen-doped carbon dots are introduced as a novel substrate suitable for enzyme immobilization in electrochemical detection metods. Nitrogen-doped carbon dots are easily synthesised from polyacrylamide in just one step. With the help of the amino group on chitosan, glucose oxidase is immobilized on nitrogen-doped carbon dots-modified carbon glassy electrodes by amino-carboxyl reactions. The nitrogen-induced charge delocalization at nitrogen-doped carbon dots can enhance the electrocatalytic activity toward the reduction of O₂. The specific amino-carboxyl reaction provides strong and stable immobilization of GOx on electrodes. The developed biosensor responds efficiently to the presence of glucose in serum samples over the concentration range from 1 to 12 mM with a detection limit of 0.25 mM. This novel biosensor has good reproducibility and stability, and is highly selective for glucose determination under physiological conditions. These results indicate that N-doped quantum dots represent a novel candidate material for the construction of electrochemical biosensors.

Antigen based detection of cystic echinococcosis in buffaloes using ELISA and Dot-EIA.

PubMed

Sangaran, A; Bino Sundar, S T; Latha, Bhaskaran Ravi

2017-03-01

Cystic echinococcosis is caused by the larval stage of the dog tapeworm, Echinococcus granulosus . The disease is recognized as one of the world's major zoonoses affecting human beings and domestic animals apart from its economic and public health importance. Development of the cysts in the intermediate host such as buffaloes occurs in the lungs, liver and other organs. In this study, detection of circulating antigen in the diagnosis of cystic echinococcosis in buffaloes was done using enzyme linked immunosorbent assay and Dot-Enzyme immunoassay (Dot-EIA). The sensitivity and specificity were determined as 89 and 92 % respectively, whereas those of Dot-EIA were determined as 94 and 96 %.

Development of Encapsulated Lithium Hydride Thermal Energy Storage for Space Power Systems,

DTIC Science & Technology

1987-12-01

equation can be approximated by dA + I • 27rdr[ dr V0 % % ORNL -DWG 87- 4427 ETD r(min) 0 12 3 4 5 0 2 -. E 4 3 SOLID 4 ~h (r) VAPORLIQUID 5 Fig. 3.11. Bubble...MORRIS ET AL DEC 87 UNCLASSIFIED ORNL /TM-i84t 3 DE-R5-840R214" F/G 14/4 L Iusmommmmi mhnnnnEnhihiI mnEElI/ihliI/E ElllllEll/IlEI ElllhEEEEEElhE EIIEE...E-EhhE IliEEEEEihlEEE 1111 1112.0!’ ’ - 1.8 1.1125 11111 .4 1111.6 MICPOCOP RESOLUTION TEST CHAR *.t 0 0 0 0 0 0 0 *:J* l~.~ omi ORNL /TM-10413 OAK

Waste certification program plan for Oak Ridge National Laboratory. Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orrin, R.C.

1997-05-01

This document defines the waste certification program developed for implementation at Oak Ridge National Laboratory (ORNL). The document describes the program structure, logic, and methodology for certification of ORNL wastes. The purpose of the waste certification program is to provide assurance that wastes are properly characterized and that the Waste Acceptance Criteria (WAC) for receiving facilities are met. The program meets the waste certification requirements outlined in US Department of Energy (DOE) Order 5820.2A, Radioactive Waste Management, and ensures that 40 CFR documentation requirements for waste characterization are met for mixed (both radioactive and hazardous) and hazardous (including polychlorinated biphenyls)more » waste. Program activities will be conducted according to ORNL Level 1 document requirements.« less

Overview of Fuel Rod Simulator Usage at ORNL

NASA Astrophysics Data System (ADS)

Ott, Larry J.; McCulloch, Reg

2004-02-01

During the 1970s and early 1980s, the Oak Ridge National Laboratory (ORNL) operated large out-of-reactor experimental facilities to resolve thermal-hydraulic safety issues in nuclear reactors. The fundamental research ranged from material mechanical behavior of fuel cladding during the depressurization phase of a loss-of-coolant accident (LOCA) to basic heat transfer research in gas- or sodium-cooled cores. The largest facility simulated the initial phase (less than 1 min. of transient time) of a LOCA in a commercial pressurized-water reactor. The nonnuclear reactor cores of these facilities were mimicked via advanced, highly instrumented electric fuel rod simulators locally manufactured at ORNL. This paper provides an overview of these experimental facilities with an emphasis on the fuel rod simulators.

Making Ternary Quantum Dots From Single-Source Precursors

NASA Technical Reports Server (NTRS)

Bailey, Sheila; Banger, Kulbinder; Castro, Stephanie; Hepp, Aloysius

2007-01-01

A process has been devised for making ternary (specifically, CuInS2) nanocrystals for use as quantum dots (QDs) in a contemplated next generation of high-efficiency solar photovoltaic cells. The process parameters can be chosen to tailor the sizes (and, thus, the absorption and emission spectra) of the QDs.

Polydiacetylene-enclosed near-infrared fluorescent semiconducting polymer dots for bioimaging and sensing.

PubMed

Wu, Pei-Jing; Kuo, Shih-Yu; Huang, Ya-Chi; Chen, Chuan-Pin; Chan, Yang-Hsiang

2014-05-20

Semiconducting polymer dots (P-dots) recently have emerged as a new type of ultrabright fluorescent probe with promising applications in biological imaging and detection. With the increasing desire for near-infrared (NIR) fluorescing probes for in vivo biological measurements, the currently available NIR-emitting P-dots are very limited and the leaching of the encapsulated dyes/polymers has usually been a concern. To address this challenge, we first embedded the NIR dyes into the matrix of poly[(9,9-dioctylfluorene)-co-2,1,3-benzothiadiazole-co-4,7-di(thiophen-2-yl)-2,1,3-benzothiadiazole] (PF-BT-DBT) polymer and then enclosed the doped P-dots with polydiacetylenes (PDAs) to avoid potential leakage of the entrapped NIR dyes from the P-dot matrix. These PDA-enclosed NIR-emitting P-dots not only emitted much stronger NIR fluorescence than conventional organic molecules but also exhibited enhanced photostability over CdTe quantum dots, free NIR dyes, and gold nanoclusters. We next conjugated biomolecules onto the surface of the resulting P-dots and demonstrated their capability for specific cellular labeling without any noticeable nonspecific binding. To employ this new class of material as a facile sensing platform, an easy-to-prepare test paper, obtained by soaking the paper into the PDA-enclosed NIR-emitting P-dot solution, was used to sense external stimuli such as ions, temperature, or pH, depending on the surface functionalization of PDAs. We believe these PDA-coated NIR-fluorescing P-dots will be very useful in a variety of bioimaging and analytical applications.

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo.

PubMed

Paris-Robidas, Sarah; Brouard, Danny; Emond, Vincent; Parent, Martin; Calon, Frédéric

2016-04-01

Receptors located on brain capillary endothelial cells forming the blood-brain barrier are the target of most brain drug delivery approaches. Yet, direct subcellular evidence of vectorized transport of nanoformulations into the brain is lacking. To resolve this question, quantum dots were conjugated to monoclonal antibodies (Ri7) targeting the murine transferrin receptor. Specific transferrin receptor-mediated endocytosis of Ri7-quantum dots was first confirmed in N2A and bEnd5 cells. After intravenous injection in mice, Ri7-quantum dots exhibited a fourfold higher volume of distribution in brain tissues, compared to controls. Immunofluorescence analysis showed that Ri7-quantum dots were sequestered throughout the cerebral vasculature 30 min, 1 h, and 4 h post injection, with a decline of signal intensity after 24 h. Transmission electron microscopic studies confirmed that Ri7-quantum dots were massively internalized by brain capillary endothelial cells, averaging 37 ± 4 Ri7-quantum dots/cell 1 h after injection. Most quantum dots within brain capillary endothelial cells were observed in small vesicles (58%), with a smaller proportion detected in tubular structures or in multivesicular bodies. Parenchymal penetration of Ri7-quantum dots was extremely low and comparable to control IgG. Our results show that systemically administered Ri7-quantum dots complexes undergo extensive endocytosis by brain capillary endothelial cells and open the door for novel therapeutic approaches based on brain endothelial cell drug delivery. © The Author(s) 2015.

Constraint-Based Routing Models for the Transport of Radioactive Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peterson, Steven K

2015-01-01

The Department of Energy (DOE) has a historic programmatic interest in the safe and secure routing, tracking, and transportation risk analysis of radiological materials in the United States. In order to address these program goals, DOE has funded the development of several tools and related systems designed to provide insight to planners and other professionals handling radioactive materials shipments. These systems include the WebTRAGIS (Transportation Routing Analysis Geographic Information System) platform. WebTRAGIS is a browser-based routing application developed at Oak Ridge National Laboratory (ORNL) focused primarily on the safe transport of spent nuclear fuel from US nuclear reactors via railway,more » highway, or waterway. It is also used for the transport planning of low-level radiological waste to depositories such as the Waste Isolation Pilot Plant (WIPP) facility. One particular feature of WebTRAGIS is its coupling with high-resolution population data from ORNL s LandScan project. This allows users to obtain highly accurate population count and density information for use in route planning and risk analysis. To perform the routing and risk analysis WebTRAGIS incorporates a basic routing model methodology, with the additional application of various constraints designed to mimic US Department of Transportation (DOT), DOE, and Nuclear Regulatory Commission (NRC) regulations. Aside from the routing models available in WebTRAGIS, the system relies on detailed or specialized modal networks for the route solutions. These include a highly detailed network model of the US railroad system, the inland and coastal waterways, and a specialized highway network that focuses on the US interstate system and the designated hazardous materials and Highway Route Controlled Quantity (HRCQ) -designated roadways. The route constraints in WebTRAGIS rely upon a series of attributes assigned to the various components of the different modal networks. Routes are determined via a constrained shortest-path Dijkstra algorithm that has an assigned impedance factor. The route constraints modify the various impedance weights to bias or prefer particular network characteristics as desired by the user. Both the basic route model and the constrained impedance function calculations are determined by a series of network characteristics and shipment types. The study examines solutions under various constraints modeled by WebTRAGIS including possible routes from select shut-down reactor sites in the US to specific locations in the US. For purposes of illustration, the designated destinations are Oak Ridge National Laboratory in Tennessee and the Savannah River Site in South Carolina. To the degree that routes express sameness or variety under constraints serves to illustrate either a) the determinism of particular transport modes by either configuration or regulatory compliance, and/or b) the variety of constrained routes that are regulation compliant but may not be operationally feasible.« less

Allowable residual contamination levels of radionuclides in soil from pathway analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nyquist, J.E.; Baes, C.F. III

1987-01-01

The uncertainty regarding radionuclide distributions among Remedial Action Program (RAP) sites and long-term decommissioning and closure options for these sites requires a flexible approach capable of handling different levels of contamination, dose limits, and closure scenarios. We identified a commercially available pathway analysis model, DECOM, which had been used previously in support of remedial activities involving contaminated soil at the Savannah River Plant. The DECOM computer code, which estimates concentrations of radionuclides uniformly distributed in soil that correspond to an annual effective dose equivalent, is written in BASIC and runs on an IBM PC or compatible microcomputer. We obtained themore » latest version of DECOM and modified it to make it more user friendly and applicable to the Oak Ridge National Laboratory (ORNL) RAP. Some modifications involved changes in default parameters or changes in models based on approaches used by the EPA in regulating remedial actions for hazardous substances. We created a version of DECOM as a LOTUS spreadsheet, using the same models as the BASIC version of DECOM. We discuss the specific modeling approaches taken, the regulatory framework that guided our efforts, the strengths and limitations of each approach, and areas for improvement. We also demonstrate how the LOTUS version of DECOM can be applied to specific problems that may be encountered during ORNL RAP activities. 18 refs., 2 figs., 3 tabs.« less

Is the DOTS strategy sufficient to achieve tuberculosis control in low- and middle-income countries? 1. Need for interventions in universities and medical schools.

PubMed

Caminero, J A

2003-06-01

Now that progress is gradually being made in the implementation of the DOTS strategy in low-income countries, we must take into account the fact that nearly 30% of all tuberculosis (TB) cases worldwide occur in middle-income countries, which usually have an adequate health infrastructure and sufficient economic resources for TB control. These countries nevertheless have other limitations that make it necessary to develop other aspects in addition to the DOTS strategy. These can be summarised in three main themes: 1) adequate coordination of all health structures involved in TB management, ensuring that they follow the basic norms of the National Tuberculosis Programme (NTP), 2) direct intervention in universities and medical schools, which are ubiquitous in such countries, and 3) specific collaboration with specialists and physicians in private practice, an important obstacle to the success of NTPs in several countries. A detailed analysis is presented of strategies that need to be implemented in different countries depending on their economic resources and their TB situation. The need to carry out specific interventions in addition to training in DOTS in universities and medical schools in order to improve TB control is discussed. A specific project in this area developed by the IUATLD in Latin America is described.

Federal Data Repository Research: Recent Developments in Mercury Search System Architecture

NASA Astrophysics Data System (ADS)

Devarakonda, R.

2015-12-01

New data intensive project initiatives needs new generation data system architecture. This presentation will discuss the recent developments in Mercury System [1] including adoption, challenges, and future efforts to handle such data intensive projects. Mercury is a combination of three main tools (i) Data/Metadata registration Tool (Online Metadata Editor): The new Online Metadata Editor (OME) is a web-based tool to help document the scientific data in a well-structured, popular scientific metadata formats. (ii) Search and Visualization Tool: Provides a single portal to information contained in disparate data management systems. It facilitates distributed metadata management, data discovery, and various visuzalization capabilities. (iii) Data Citation Tool: In collaboration with Department of Energy's Oak Ridge National Laboratory (ORNL) Mercury Consortium (funded by NASA, USGS and DOE), established a Digital Object Identifier (DOI) service. Mercury is a open source system, developed and managed at Oak Ridge National Laboratory and is currently being funded by three federal agencies, including NASA, USGS and DOE. It provides access to millions of bio-geo-chemical and ecological data; 30,000 scientists use it each month. Some recent data intensive projects that are using Mercury tool: USGS Science Data Catalog (http://data.usgs.gov/), Next-Generation Ecosystem Experiments (http://ngee-arctic.ornl.gov/), Carbon Dioxide Information Analysis Center (http://cdiac.ornl.gov/), Oak Ridge National Laboratory - Distributed Active Archive Center (http://daac.ornl.gov), SoilSCAPE (http://mercury.ornl.gov/soilscape). References: [1] Devarakonda, Ranjeet, et al. "Mercury: reusable metadata management, data discovery and access system." Earth Science Informatics 3.1-2 (2010): 87-94.

Interpretation of the results of the CORA-33 dry core BWR test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ott, L.J.; Hagen, S.

All BWR degraded core experiments performed prior to CORA-33 were conducted under ``wet`` core degradation conditions for which water remains within the core and continuous steaming feeds metal/steam oxidation reactions on the in-core metallic surfaces. However, one dominant set of accident scenarios would occur with reduced metal oxidation under ``dry`` core degradation conditions and, prior to CORA-33, this set had been neglected experimentally. The CORA-33 experiment was designed specifically to address this dominant set of BWR ``dry`` core severe accident scenarios and to partially resolve phenomenological uncertainties concerning the behavior of relocating metallic melts draining into the lower regions ofmore » a ``dry`` BWR core. CORA-33 was conducted on October 1, 1992, in the CORA tests facility at KfK. Review of the CORA-33 data indicates that the test objectives were achieved; that is, core degradation occurred at a core heatup rate and a test section axial temperature profile that are prototypic of full-core nuclear power plant (NPP) simulations at ``dry`` core conditions. Simulations of the CORA-33 test at ORNL have required modification of existing control blade/canister materials interaction models to include the eutectic melting of the stainless steel/Zircaloy interaction products and the heat of mixing of stainless steel and Zircaloy. The timing and location of canister failure and melt intrusion into the fuel assembly appear to be adequately simulated by the ORNL models. This paper will present the results of the posttest analyses carried out at ORNL based upon the experimental data and the posttest examination of the test bundle at KfK. The implications of these results with respect to degraded core modeling and the associated safety issues are also discussed.« less

Environmental Sciences Laboratory dedication, February 26-27, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Auerbach, S.I.; Millemann, N.T.

1980-09-01

The dedication of the new Environmental Sciences Laboratory coincided with the 25th year of the establishment of the science of ecology at Oak Ridge National Laboratory. That quarter century witnessed the evolution of ecology from an obscure, backwater discipline of biology to a broadly used, everyday household word. The transition reflected broad and basic changes in our social and cultural view of the world. This was brought about as a result of the awareness developed in our society of the importance of the environment, coupled with efforts of ecologists and other environmental scientists who identified, clarified, and formulated the issuesmore » and challenges of environmental protection for both the lay public and the scientific community. In many respects, the activities in ecology at ORNL were a microcosm of the broader social scene; the particular problems of the environment associated with atomic energy needed to be defined in scientific terms and articulated in both the specific and general sense for a larger audience which was unfamiliar with the field and somewhat alien to its concepts and philosophy. The success of this effort is reflected in the existence of the new Environmental Sciences Laboratory. This dedication volume brings together the thoughts and reflections of many of these scientists whose efforts contributed in a unique and individualistic fashion not only to ORNL but also to the national identification of ecology and its importance to the achievement of our national goals. Their remarks and presentations are not only a pleasant and personally gratifying recapitulation of the past and of ORNL's contributions to ecology but also portend some of the challenges to ecology in the future.« less

Defense Remote Handled Transuranic Waste Cost/Schedule Optimization Study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, G.D.; Beaulieu, D.H.; Wolaver, R.W.

1986-11-01

The purpose of this study is to provide the DOE information with which it can establish the most efficient program for the long management and disposal, in the Waste Isolation Pilot Plant (WIPP), of remote handled (RH) transuranic (TRU) waste. To fulfill this purpose, a comprehensive review of waste characteristics, existing and projected waste inventories, processing and transportation options, and WIPP requirements was made. Cost differences between waste management alternatives were analyzed and compared to an established baseline. The result of this study is an information package that DOE can use as the basis for policy decisions. As part ofmore » this study, a comprehensive list of alternatives for each element of the baseline was developed and reviewed with the sites. The principle conclusions of the study follow. A single processing facility for RH TRU waste is both necessary and sufficient. The RH TRU processing facility should be located at Oak Ridge National Laboratory (ORNL). Shielding of RH TRU to contact handled levels is not an economic alternative in general, but is an acceptable alternative for specific waste streams. Compaction is only cost effective at the ORNL processing facility, with a possible exception at Hanford for small compaction of paint cans of newly generated glovebox waste. It is more cost effective to ship certified waste to WIPP in 55-gal drums than in canisters, assuming a suitable drum cask becomes available. Some waste forms cannot be packaged in drums, a canister/shielded cask capability is also required. To achieve the desired disposal rate, the ORNL processing facility must be operational by 1996. Implementing the conclusions of this study can save approximately $110 million, compared to the baseline, in facility, transportation, and interim storage costs through the year 2013. 10 figs., 28 tabs.« less

Liability of concrete performance-based specification for Georgia DOT projects.

DOT National Transportation Integrated Search

2013-12-01

Performance-based specifications provide an alternative means of designing concrete to meet : specific performance-related goals. Instead of specifying materials, means, and proportions, as : current prescriptive specifications do, a performance-base...

Final Report: Sensorpedia Phase 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorman, Bryan L; Resseguie, David R

2011-02-01

This report is a summary of the Oak Ridge National Laboratory s (ORNL s) Phase 3 development of Sensorpedia, a sensor information sharing platform. Sensorpedia is ORNL s Wikipedia for Sensors. The overall goal of Sensorpedia is to enable global scale sensor information sharing for scientific research, national security and defense, public health and safety, emergency preparedness and response, and general community awareness and outreach.

Enabling Technologies for Medium Additive Manufacturing (MAAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, Bradley S.; Love, Lonnie J.; Chesser, Phillip C.

ORNL has worked with Cosine Additive, Inc. on the design of MAAM extrusion components. The objective is to improve the print speed and part quality. A pellet extruder has been procured and integrated into the MAAM printer. Print speed has been greatly enhanced. In addition, ORNL and Cosine Additive have worked on alternative designs for a pellet drying and feed system.

ORNL superconducting technology program for electric power systems

NASA Astrophysics Data System (ADS)

Hawsey, R. A.

1994-04-01

The Oak Ridge National Laboratory (ORNL) Superconducting Technology Program is conducted as part of a national effort by the US Department of Energy's Office of Energy Efficiency and Renewable Energy to develop the technology base needed by US industry for commercial development of electric power applications of high-temperature superconductivity. The two major elements of this program are conductor development and applications development. This document describes the major research and development activities for this program together with related accomplishments. The technical progress reported was summarized from information prepared for the FY 1993 Annual Program Review held July 28--29, 1993. This ORNL program is highly leveraged by the staff and other resources of US industry and universities. In fact, nearly three-fourths of the ORNL effort is devoted to industrial competitiveness projects with private companies. Interlaboratory teams are also in place on a number of industry-driven projects. Patent disclosures, working group meetings, staff exchanges, and joint publications and presentations ensure that there is technology transfer to US industry. Working together, the collaborative teams are making rapid progress in solving the scientific and technical issues necessary for the commercialization of long lengths of practical high-temperature superconductor wire and wire products.

Recent Advances in Resonance Region Nuclear Data Measurements and Analyses for Supporting Nuclear Energy Applications

NASA Astrophysics Data System (ADS)

Dunn, Michael

2008-10-01

For over 30 years, the Oak Ridge National Laboratory (ORNL) has performed research and development to provide more accurate nuclear cross-section data in the resonance region. The ORNL Nuclear Data (ND) Program consists of four complementary areas of research: (1) cross-section measurements at the Oak Ridge Electron Linear Accelerator; (2) resonance analysis methods development with the SAMMY R-matrix analysis software; (3) cross-section evaluation development; and (4) cross-section processing methods development with the AMPX software system. The ND Program is tightly coupled with nuclear fuel cycle analyses and radiation transport methods development efforts at ORNL. Thus, nuclear data work is performed in concert with nuclear science and technology needs and requirements. Recent advances in each component of the ORNL ND Program have led to improvements in resonance region measurements, R-matrix analyses, cross-section evaluations, and processing capabilities that directly support radiation transport research and development. Of particular importance are the improvements in cross-section covariance data evaluation and processing capabilities. The benefit of these advances to nuclear science and technology research and development will be discussed during the symposium on Nuclear Physics Research Connections to Nuclear Energy.

Data and Workflow Management Challenges in Global Adjoint Tomography

NASA Astrophysics Data System (ADS)

Lei, W.; Ruan, Y.; Smith, J. A.; Modrak, R. T.; Orsvuran, R.; Krischer, L.; Chen, Y.; Balasubramanian, V.; Hill, J.; Turilli, M.; Bozdag, E.; Lefebvre, M. P.; Jha, S.; Tromp, J.

2017-12-01

It is crucial to take the complete physics of wave propagation into account in seismic tomography to further improve the resolution of tomographic images. The adjoint method is an efficient way of incorporating 3D wave simulations in seismic tomography. However, global adjoint tomography is computationally expensive, requiring thousands of wavefield simulations and massive data processing. Through our collaboration with the Oak Ridge National Laboratory (ORNL) computing group and an allocation on Titan, ORNL's GPU-accelerated supercomputer, we are now performing our global inversions by assimilating waveform data from over 1,000 earthquakes. The first challenge we encountered is dealing with the sheer amount of seismic data. Data processing based on conventional data formats and processing tools (such as SAC), which are not designed for parallel systems, becomes our major bottleneck. To facilitate the data processing procedures, we designed the Adaptive Seismic Data Format (ASDF) and developed a set of Python-based processing tools to replace legacy FORTRAN-based software. These tools greatly enhance reproducibility and accountability while taking full advantage of highly parallel system and showing superior scaling on modern computational platforms. The second challenge is that the data processing workflow contains more than 10 sub-procedures, making it delicate to handle and prone to human mistakes. To reduce human intervention as much as possible, we are developing a framework specifically designed for seismic inversion based on the state-of-the art workflow management research, specifically the Ensemble Toolkit (EnTK), in collaboration with the RADICAL team from Rutgers University. Using the initial developments of the EnTK, we are able to utilize the full computing power of the data processing cluster RHEA at ORNL while keeping human interaction to a minimum and greatly reducing the data processing time. Thanks to all the improvements, we are now able to perform iterations fast enough on more than a 1,000 earthquakes dataset. Starting from model GLAD-M15 (Bozdag et al., 2016), an elastic 3D model with a transversely isotropic upper mantle, we have successfully performed 5 iterations. Our goal is to finish 10 iterations, i.e., generating GLAD M25* by the end of this year.

49 CFR 179.300-9 - Welding.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.300-9 Section 179.300-9... Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-9 Welding. (a) Longitudinal... fusion welded on class DOT-110A tanks. Welding procedures, welders and fabricators must be approved in...

Hermaphroditism in the dash-and-dot goatfish Parupeneus barberinus.

PubMed

Longenecker, K; Langston, R; Crane, M

2017-03-01

Presence of bisexual individuals and a sex-specific bimodal size distribution are suggestive of protogyny in the dash-and-dot goatfish Parupeneus barberinus, but the most parsimonious interpretation of histological analysis is juvenile hermaphroditism. This is the first report of hermaphroditism in the Mullidae. © 2017 The Fisheries Society of the British Isles.

49 CFR 107.807 - Approval of non-domestic chemical analyses and tests.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 2 2013-10-01 2013-10-01 false Approval of non-domestic chemical analyses and... Requalifiers, and Non-domestic Chemical Analyses and Tests of DOT Specification Cylinders § 107.807 Approval of non-domestic chemical analyses and tests. (a) General. A person who seeks to manufacture DOT...

D-Glucosamine Conjugation Accelerates the Labeling Efficiency of Quantum Dots in Osteoblastic Cells

PubMed Central

Xie, Ming-Fang

2014-01-01

Quantum dots (QDs) are useful imaging tools in the medical and biological fields due to their optical properties, such as a high fluorescence intensity, remarkable resistance to photobleaching, broad absorption spectra, and narrow emission spectra. This is the first study to investigate the uptake of carboxylated QDs conjugated with D-glucosamine (core size: approximately 3 nm, final modified size: 20–30 nm) into cultured osteoblastic cells. The QDs attached to the cell surface and were transported into the cytoplasm within approximately three hours of culture, whose process was clearly demonstrated using specific fluorescent staining of the cell membrane. Although the intranuclear distribution was not observed, a dramatic decrease in the transfer of quantum dots into the cytoplasm was recognized after approximately seven days of culture. Other interesting phenomena include the escape of the quantum dots from lysosomes in the cytoplasm, as confirmed by the merging of both QD fluorescence and specific fluorescent staining of lysosomes in the cytoplasm. These findings suggest that D-glucosamine conjugation enhances proton absorption in acid organelles and promotes the lysosomal escape of QDs. PMID:24818156

Operating experience with LEAP from the perspective of the computing applications analyst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ford, W.E. III; Horwedel, J.E.; McAdoo, J.W.

1981-05-01

The Long-Term Energy Analysis Program (LEAP), which was used for the energy price-quantity projections in the 1978 Annual Report to Congress (ARC '78) and used in an ORNL research program to develop and demonstrate a procedure for evaluating energy-economic modeling computer codes and the important results derived therefrom, is discussed. The LEAP system used in the ORNL research, the mechanics of executing LEAP, and the personnel skills required to execute the system are described. In addition, a LEAP sample problem, subroutine hierarchical flowcharts, and input tables for the ARC '78 energy-economic model are included. Results of a study to testmore » the capability of the LEAP system used in the ORNL research to reproduce the ARC '78 results credited to LEAP are presented.« less

Aqp5 Is a New Transcriptional Target of Dot1a and a Regulator of Aqp2

PubMed Central

Zhang, Xi; Zhou, Qiaoling; Li, Ju-Mei; Berger, Stefan; Borok, Zea; Zhou, Beiyun; Xiao, Zhou; Yin, Hongling; Liu, Mingyao; Wang, Ying; Jin, Jianping; Blackburn, Michael R.; Xia, Yang; Zhang, Wenzheng

2013-01-01

Dot1l encodes histone H3 K79 methyltransferase Dot1a. Mice with Dot1l deficiency in renal Aqp2-expressing cells (Dot1lAC) develop polyuria by unknown mechanisms. Here, we report that Aqp5 links Dot1l deletion to polyuria through Aqp2. cDNA array analysis revealed and real-time RT-qPCR validated Aqp5 as the most upregulated gene in Dot1lAC vs. control mice. Aqp5 protein is barely detectable in controls, but robustly expressed in the Dot1lAC kidneys, where it colocalizes with Aqp2. The upregulation of Aqp5 is coupled with reduced association of Dot1a and H3 dimethyl K79 with specific subregions in Aqp5 5′ flanking region in Dot1lAC vs. control mice. In vitro studies in IMCD3, MLE-15 and 293Tcells using multiple approaches including real-time RT-qPCR, luciferase reporter assay, cell surface biotinylation assay, colocalization, and co-immunoprecipitation uncovered that Dot1a represses Aqp5. Human AQP5 interacts with AQP2 and impairs its cell surface localization. The AQP5/AQP2 complex partially resides in the ER/Golgi. Consistently, AQP5 is expressed in none of 15 normal controls, but in all of 17 kidney biopsies from patients with diabetic nephropathy. In the patients with diabetic nephropathy, AQP5 colocalizes with AQP2 in the perinuclear region and AQP5 expression is associated with impaired cellular H3 dimethyl K79. Taken together, these data for the first time identify Aqp5 as a Dot1a potential transcriptional target, and an Aqp2 binding partner and regulator, and suggest that the upregulated Aqp5 may contribute to polyuria, possibly by impairing Aqp2 membrane localization, in Dot1lAC mice and in patients with diabetic nephropathy. PMID:23326416

49 CFR 179.221-1 - Individual specification requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.221-1...

49 CFR 179.201-1 - Individual specification requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-1...

49 CFR 179.201-1 - Individual specification requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-1...

49 CFR 179.201-1 - Individual specification requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-1...

49 CFR 179.221-1 - Individual specification requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.221-1...

Highly Sensitive Detection of Glucose by a "Turn-Off-On" Fluorescent Probe Using Gadolinium-Doped Carbon Dots and Carbon Microparticles.

PubMed

Hu, Meixin; Qi, Jianrong; Ruan, Jing; Shen, Guangxia

2018-06-01

Carbon dots, as a potential substitute for semiconductor quantum dots, have drawn great interest in recent years. The preparation of fluorescent carbon dots has been made easy with many significant advances, but the complicated purifying processes, low quantum yield, and blue emission wavelength still limit its wider application in biosensors, biomedicine, and photonic devices. Here we report a strategy to synthesis Gd-doped carbon dots (Gd-Cdots) of super-high quantum yield with a microwave assisted hydrothermal method. The Gd-Cdots, with a diameter of 47∼8 nm, can be purified easily with conventional centrifugal techniques. Carbon microparticles (CMPs) have also been synthesized with a similar procedure. Meanwhile, we demonstrated a novel "turn-off-on" fluorescent biosensor, which has been developed for highly sensitive detection of glucose using Gd-doped carbon dots as probes. The proposed biosensor has exhibited low-cost and non-toxic properties, with high sensitivity and good specificity. In addition, the results in real blood samples further confirmed it as a promising application in diabetes diagnosis.

Controlling the influence of Auger recombination on the performance of quantum-dot light-emitting diodes

PubMed Central

Bae, Wan Ki; Park, Young-Shin; Lim, Jaehoon; Lee, Donggu; Padilha, Lazaro A.; McDaniel, Hunter; Robel, Istvan; Lee, Changhee; Pietryga, Jeffrey M.; Klimov, Victor I.

2013-01-01

Development of light-emitting diodes (LEDs) based on colloidal quantum dots is driven by attractive properties of these fluorophores such as spectrally narrow, tunable emission and facile processibility via solution-based methods. A current obstacle towards improved LED performance is an incomplete understanding of the roles of extrinsic factors, such as non-radiative recombination at surface defects, versus intrinsic processes, such as multicarrier Auger recombination or electron-hole separation due to applied electric field. Here we address this problem with studies that correlate the excited state dynamics of structurally engineered quantum dots with their emissive performance within LEDs. We find that because of significant charging of quantum dots with extra electrons, Auger recombination greatly impacts both LED efficiency and the onset of efficiency roll-off at high currents. Further, we demonstrate two specific approaches for mitigating this problem using heterostructured quantum dots, either by suppressing Auger decay through the introduction of an intermediate alloyed layer, or by using an additional shell that impedes electron transfer into the quantum dot to help balance electron and hole injection. PMID:24157692

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palumbo, Anthony V.

Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), the University of Tennessee (UT), and Florida State University (FSU). ORNL serves as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project is in its second year. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

Cadmium sulfide quantum dots induce oxidative stress and behavioral impairments in the marine clam Scrobicularia plana.

PubMed

Buffet, Pierre-Emmanuel; Zalouk-Vergnoux, Aurore; Poirier, Laurence; Lopes, Christelle; Risso-de-Faverney, Christine; Guibbolini, Marielle; Gilliland, Douglas; Perrein-Ettajani, Hanane; Valsami-Jones, Eugenia; Mouneyrac, Catherine

2015-07-01

Cadmium sulfide (CdS) quantum dots have a number of current applications in electronics and solar cells and significant future potential in medicine. The aim of the present study was to examine the toxic effects of CdS quantum dots on the marine clam Scrobicularia plana exposed for 14 d to these nanomaterials (10 µg Cd L(-1) ) in natural seawater and to compare them with soluble Cd. Measurement of labile Cd released from CdS quantum dots showed that 52% of CdS quantum dots remained in the nanoparticulate form. Clams accumulated the same levels of Cd regardless of the form in which it was delivered (soluble Cd vs CdS quantum dots). However, significant changes in biochemical responses were observed in clams exposed to CdS quantum dots compared with soluble Cd. Increased activities of catalase and glutathione-S-transferase were significantly higher in clams exposed in seawater to Cd as the nanoparticulate versus the soluble form, suggesting a specific nano effect. The behavior of S. plana in sediment showed impairments of foot movements only in the case of exposure to CdS quantum dots. The results show that oxidative stress and behavior biomarkers are sensitive predictors of CdS quantum dots toxicity in S. plana. Such responses, appearing well before changes might occur at the population level, demonstrate the usefulness of this model species and type of biomarker in the assessment of nanoparticle contamination in estuarine ecosystems. © 2015 SETAC.

Quantum dot-linked immunosorbent assay (QLISA) using orientation-directed antibodies.

PubMed

Suzuki, Miho; Udaka, Hikari; Fukuda, Takeshi

2017-09-05

An approach similar to the enzyme-linked immunosorbent assay (ELISA), with the advantage of saving time and effort but exhibiting high performance, was developed using orientation-directed half-part antibodies immobilized on CdSe/ZnS quantum dots. ELISA is a widely accepted assay used to detect the presence of a target substance. However, it takes time to quantify the target with specificity and sensitivity owing to signal amplification. In this study, CdSe/ZnS quantum dots are introduced as bright and photobleaching-tolerant fluorescent materials. Since hydrophilic surface coating of quantum dots rendered biocompatibility and functional groups for chemical reactions, the quantum dots were modified with half-sized antibodies after partial reduction. The half-sized antibody could be bound to a quantum dot through a unique thiol site to properly display the recognition domain for the core process of ELISA, which is an antigen-antibody interaction. The reducing conditions were investigated to generate efficient conjugates of quantum dots and half-sized antibodies. This was applied to IL-6 detection, as the quantification of IL-6 is significant owing to its close relationships with various biomedical phenomena that cause different diseases. An ELISA-like assay with CdSe/ZnS quantum dot institution (QLISA; Quantum dot-linked immunosorbent assay) was developed to detect 0.05ng/mL IL-6, which makes it sufficiently sensitive as an immunosorbent assay. Copyright © 2017 Elsevier B.V. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dinwiddie, R. B.; Wang, H.; Johnnerfelt, B.

Zinc Oxide based surge arresters are widely used to safeguard and improve reliability of the electrical power delivering and transmission systems. The primary application of surge arresters is to protect valuable components such as transformers from lightning strikes and switching transients in the transmission lines. Metal-oxide-varistor blocks (MOV, e.g. ZnO) are used in surge arrester assemblies. ORNL has developed an advanced infrared imaging technique to monitor the joule heating during transient heating of small varistors. In a recent short-term R&D effort, researchers from ABB and ORNL have expanded the use of IR imaging to larger station-class arrester blocks. An on-sitemore » visit to the ABB facility demonstrated that the use of IR imaging is not only feasible but also has the potential to improve arrester quality and reliability. The ASEA Brown Bower (ABB) Power and Technology & Development Company located at Greensburg PA having benefited from collaborative R&D cooperation with ORNL. ABB has decided a follow-on CRADA project is very important. While the previous efforts to study surge arresters included broader studies of IR imaging and computer modeling, ABB has recognized the potential of IR imaging, decided to focus on this particular area. ABB plans to use this technique to systematically study the possible defects in the arrester fabrication process. ORNL will improve the real-time monitoring capability and provide analysis of the infrared images. More importantly, the IR images will help us understand transient heating in a ceramic material from the scientific standpoint. With the improved IR imaging ABB and ORNL will employ the IR system to visualize manufacturing defects that could not be detected otherwise. The proposed on-site tests at ABB Power Technology & Development processing facility will identify the defects and also allow quick adjustments to be made since the resulting products can be inspected immediately. ABB matched the DOE $50K funding with $50K funds-in to ORNL. ABB also provided about $75K in-kind effort for on-site testing, and R&D to improve the fabrication process.« less

Data Sharing Report Characterization of Isotope Row Facilities Oak Ridge National Laboratory Oak Ridge TN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weaver, Phyllis C.

The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management (EM-OR) requested that Oak Ridge Associated Universities (ORAU), working under the Oak Ridge Institute for Science and Education (ORISE) contract, provide technical and independent waste management planning support using funds provided by the American Recovery and Reinvestment Act (ARRA). Specifically, DOE EM-OR requested ORAU to plan and implement a survey approach, focused on characterizing the Isotope Row Facilities located at the Oak Ridge National Laboratory (ORNL) for future determination of an appropriate disposition pathway for building debris and systems, should the buildings be demolished. The characterization effort wasmore » designed to identify and quantify radiological and chemical contamination associated with building structures and process systems. The Isotope Row Facilities discussed in this report include Bldgs. 3030, 3031, 3032, 3033, 3033A, 3034, 3036, 3093, and 3118, and are located in the northeast quadrant of the main ORNL campus area, between Hillside and Central Avenues. Construction of the isotope production facilities was initiated in the late 1940s, with the exception of Bldgs. 3033A and 3118, which were enclosed in the early 1960s. The Isotope Row facilities were intended for the purpose of light industrial use for the processing, assemblage, and storage of radionuclides used for a variety of applications (ORNL 1952 and ORAU 2013). The Isotope Row Facilities provided laboratory and support services as part of the Isotopes Production and Distribution Program until 1989 when DOE mandated their shutdown (ORNL 1990). These facilities performed diverse research and developmental experiments in support of isotopes production. As a result of the many years of operations, various projects, and final cessation of operations, production was followed by inclusion into the surveillance and maintenance (S&M) project for eventual decontamination and decommissioning (D&D). The process for D&D and final dismantlement of facilities requires that the known contaminants of concern (COCs) be evaluated and quantified and to identify and quantify any additional contaminants in order to satisfy the waste acceptance criteria requirements for the desired disposal pathway. Known facility contaminants include, but are not limited to, asbestos-containing material (ACM), radiological contaminants, and chemical contaminants including polychlorinated biphenyls (PCBs) and metals.« less

Comparison of Prime Movers Suitable for USMC Expeditionary Power Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Theiss, T J; Conklin, J. C.; Thomas, John F.

2000-04-18

This report documents the results of the ORNL investigation into prime movers that would be desirable for the construction of a power system suitable for the United States Marine Corps (USMC) expeditionary forces under Operational Maneuvers From The Sea (OMFTS) doctrine. Discrete power levels of {approx}1, 5, 15, and 30 kW are considered. The only requirement is that the prime mover consumes diesel fuel. A brief description is given for the prime movers to describe their basic scientific foundations and relative advantages and disadvantages. A list of key attributes developed by ORNL has been weighted by the USMC to indicatemore » the level of importance. A total of 14 different prime movers were scored by ORNL personnel in four size ranges (1,5, 15, & 30 kW) for their relative strength in each attribute area. The resulting weighted analysis was used to indicate which prime movers are likely to be suitable for USMC needs. No single engine or prime mover emerged as the clear-cut favorite but several engines scored as well or better than the diesel engine. At the higher load levels (15 & 30 kW), the results indicate that the open Brayton (gas turbine) is a relatively mature technology and likely a suitable choice to meet USMC needs. At the lower power levels, the situation is more difficult and the market alone is not likely to provide an optimum solution in the time frame desired (2010). Several prime movers should be considered for future developments and may be satisfactory; specifically, the Atkinson cycle, the open Brayton cycle (gas turbine), the 2-stroke diesel. The rotary diesel and the solid oxide fuel cell should be backup candidates. Of all these prime movers, the Atkinson cycle may well be the most suitable for this application but is an immature technology. Additional demonstrations of this engine will be conducted at ORNL. If this analysis is positive, then the performance of a generator set using this engine, the open Brayton and the 2-stroke diesel should be estimated to evaluate its potential suitability for expeditionary forces. The overriding conclusion of this effort is that we feel a suitable prime mover can be found but that the development will be technically challenging and trade-offs will be made before an optimum solution is found.« less

49 CFR 179.201-1 - Individual specification requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-1...

Analysis of new measurements of Calvert Cliffs spent fuel samples using SCALE 6.2

DOE PAGES

Hu, Jianwei; Giaquinto, J. M.; Gauld, I. C.; ...

2017-04-28

High quality experimental data for isotopic compositions in irradiated fuel are important to spent fuel applications, including nuclear safeguards, spent fuel storage, transportation, and final disposal. The importance of these data has been increasingly recognized in recent years, particularly as countries like Finland and Sweden plan to open the world’s first two spent fuel geological repositories in 2020s, while other countries, including the United States, are considering extended dry fuel storage options. Destructive and nondestructive measurements of a spent fuel rod segment from a Combustion Engineering 14 × 14 fuel assembly of the Calvert Cliffs Unit 1 nuclear reactor havemore » been recently performed at Oak Ridge National Laboratory (ORNL). These ORNL measurements included two samples selected from adjacent axial locations of a fuel rod with initial enrichment of 3.038 wt% 235U, which achieved burnups close to 43.5 GWd/MTU. More than 50 different isotopes of 16 elements were measured using high precision measurement methods. Various investigations have assessed the quality of the new ORNL measurement data, including comparison to previous measurements and to calculation results. Previous measurement data for samples from the same fuel rod measured at ORNL are available from experiments performed at Pacific Northwest National Laboratory in the United States and the Khoplin Radium Institute in Russia. Detailed assembly models were developed using the newly released SCALE 6.2 code package to simulate depletion and decay of the measured fuel samples. Furthermore, results from this work show that the new ORNL measurements provide a good quality radiochemical assay data set for spent fuel with relatively high burnup and long cooling time, and they can serve as good benchmark data for nuclear burnup code validation and spent fuel studies.« less

Hazardous materials in aquatic environments of the Mississippi River Basin. Quarterly project status report, July 1, 1993--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-11-01

This document is a brief progress report from each of the research and education projects that are currently funded through the ERWM contract. During third quarter 1993, approval was given by DOE for purchase of equipment. Equipment purchases were initiated and much of the equipment has been received and installed. The committees in charge of coordination of sampling and analyses associated with the collaborative research groups continued to meet and address these issues. Sampling has been done in the lower part of Devil`s Swamp and in the Devil`s Swamp Lake area. In addition, extensive sampling has been done in Bayoumore » Trepagnier and in Bayou St. John. During this period, Tulane and Xavier Universities continued working closely with Oak Ridge National Laboratories (ORNL). The ORNL 1993 summer student internship program was completed. Plans were made for expanding the program to support 8 students next summer. Leonard Price, a Xavier University Chemistry professor and John Walz, a Tulane University Engineering professor each spent 5 weeks at ORNL. During this time these faculty worked with ORNL researchers exploring mutual interests and discussing possible future collaborations. In September, Drs. Carl Gehrs, Lee Shugart and Marshall Adams of ORNL, visited the Tulane and Xavier campuses. They presented two seminars and met with several of the investigators being supported by the ERWM contract. Tulane/Xavier project administrators participated in the Office of Technology Development`s ``New Technologies and Program Exhibition`` in the Rayburn House Office Building on September 23 and in the Hart Senate Office Building on September 27.« less

"Small" data in a big data world: archiving terrestrial ecology data at ORNL DAAC

NASA Astrophysics Data System (ADS)

Santhana Vannan, S. K.; Beaty, T.; Boyer, A.; Deb, D.; Hook, L.; Shrestha, R.; Thornton, M.; Virdi, M.; Wei, Y.; Wright, D.

2016-12-01

The Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC http://daac.ornl.gov), a NASA-funded data center, archives a diverse collection of terrestrial biogeochemistry and ecological dynamics observations and models in support of NASA's Earth Science program. The ORNL DAAC has been addressing the increasing challenge of publishing diverse small data products into an online archive while dealing with the enhanced need for integration and availability of these data to address big science questions. This paper will show examples of "small" diverse data holdings - ranging from the Daymet model output data to site-based soil moisture observation data. We define "small" by the data volume of these data products compared to petabyte scale observations. We will highlight the use of tools and services for visualizing diverse data holdings and subsetting services such as the MODIS land products subsets tool (at ORNL DAAC) that provides big MODIS data in small chunks. Digital Object Identifiers (DOI) and data citations have enhanced the availability of data. The challenge faced by data publishers now is to deal with the increased number of publishable data products and most importantly the difficulties of publishing small diverse data products into an online archive. This paper will also present our experiences designing a data curation system for these types of data. The characteristics of these data will be examined and their scientific value will be demonstrated via data citation metrics. We will present case studies of leveraging specialized tools and services that have enabled small data sets to realize their "big" scientific potential. Overall, we will provide a holistic view of the challenges and potential of small diverse terrestrial ecology data sets from data curation to distribution.

Analysis of new measurements of Calvert Cliffs spent fuel samples using SCALE 6.2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Jianwei; Giaquinto, J. M.; Gauld, I. C.

High quality experimental data for isotopic compositions in irradiated fuel are important to spent fuel applications, including nuclear safeguards, spent fuel storage, transportation, and final disposal. The importance of these data has been increasingly recognized in recent years, particularly as countries like Finland and Sweden plan to open the world’s first two spent fuel geological repositories in 2020s, while other countries, including the United States, are considering extended dry fuel storage options. Destructive and nondestructive measurements of a spent fuel rod segment from a Combustion Engineering 14 × 14 fuel assembly of the Calvert Cliffs Unit 1 nuclear reactor havemore » been recently performed at Oak Ridge National Laboratory (ORNL). These ORNL measurements included two samples selected from adjacent axial locations of a fuel rod with initial enrichment of 3.038 wt% 235U, which achieved burnups close to 43.5 GWd/MTU. More than 50 different isotopes of 16 elements were measured using high precision measurement methods. Various investigations have assessed the quality of the new ORNL measurement data, including comparison to previous measurements and to calculation results. Previous measurement data for samples from the same fuel rod measured at ORNL are available from experiments performed at Pacific Northwest National Laboratory in the United States and the Khoplin Radium Institute in Russia. Detailed assembly models were developed using the newly released SCALE 6.2 code package to simulate depletion and decay of the measured fuel samples. Furthermore, results from this work show that the new ORNL measurements provide a good quality radiochemical assay data set for spent fuel with relatively high burnup and long cooling time, and they can serve as good benchmark data for nuclear burnup code validation and spent fuel studies.« less

Materials Innovation for Next-Generation T&D Grid Components. Workshop Summary Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Emmanuel; Kramer, Caroline; Marchionini, Brian

The Materials Innovations for Next-Generation T&D Grid Components Workshop was co-sponsored by the U.S. Department of Energy (DOE) Office of Electricity Delivery and Energy Reliability and the Oak Ridge National Laboratory (ORNL) and held on August 26 27, 2015, at the ORNL campus in Oak Ridge, Tennessee. The workshop was planned and executed under the direction of workshop co-chair Dr. Kerry Cheung (DOE) and co-chair Dr. Dominic Lee (ORNL). The information contained herein is based on the results of the workshop, which was attended by nearly 50 experts from government, industry, and academia. The research needs and pathways described inmore » this report reflect the expert opinions of workshop participants, but they are not intended to represent the views of the entire electric power community.« less

BIOME: A browser-aware search and order system

NASA Technical Reports Server (NTRS)

Grubb, Jon W.; Jennings, Sarah V.; Yow, Teresa G.; Daughterty, Patricia F.

1996-01-01

The Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC), which is associated with NASA's Earth Observing System Data and Information System (EOSDIS), provides access to a large number of tabular and imagery datasets used in ecological and environmental research. Because of its large and diverse data holdings, the challenge for the ORNL DAAC is to help users find data of interest from the hundreds of thousands of files available at the DAAC without overwhelming them. Therefore, the ORNL DAAC developed the Biogeochemical Information Ordering Management Environment (BIOME), a search and order system for the World Wide Web (WWW). The WWW provides a new vehicle that allows a wide range of users access to the data. This paper describes the specialized attributes incorporated into BIOME that allow researchers easy access to an otherwise bewildering array of data products.

Reversal of an ancient sex chromosome to an autosome in Drosophila.

PubMed

Vicoso, Beatriz; Bachtrog, Doris

2013-07-18

Although transitions of sex-determination mechanisms are frequent in species with homomorphic sex chromosomes, heteromorphic sex chromosomes are thought to represent a terminal evolutionary stage owing to chromosome-specific adaptations such as dosage compensation or an accumulation of sex-specific mutations. Here we show that an autosome of Drosophila, the dot chromosome, was ancestrally a differentiated X chromosome. We analyse the whole genome of true fruitflies (Tephritidae), flesh flies (Sarcophagidae) and soldier flies (Stratiomyidae) to show that genes located on the dot chromosome of Drosophila are X-linked in outgroup species, whereas Drosophila X-linked genes are autosomal. We date this chromosomal transition to early drosophilid evolution by sequencing the genome of other Drosophilidae. Our results reveal several puzzling aspects of Drosophila dot chromosome biology to be possible remnants of its former life as a sex chromosome, such as its minor feminizing role in sex determination or its targeting by a chromosome-specific regulatory mechanism. We also show that patterns of biased gene expression of the dot chromosome during early embryogenesis, oogenesis and spermatogenesis resemble that of the current X chromosome. Thus, although sex chromosomes are not necessarily evolutionary end points and can revert back to an autosomal inheritance, the highly specialized genome architecture of this former X chromosome suggests that severe fitness costs must be overcome for such a turnover to occur.

76 FR 7482 - Operations Specifications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

...] RIN 2120-AJ45 Operations Specifications AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... carriers and foreign persons for part 129 operations specifications and establishes new standards for amendment, suspension, and termination of those operations specifications. In addition, the FAA has moved...

SCALE TSUNAMI Analysis of Critical Experiments for Validation of 233U Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mueller, Don; Rearden, Bradley T

2009-01-01

Oak Ridge National Laboratory (ORNL) staff used the SCALE TSUNAMI tools to provide a demonstration evaluation of critical experiments considered for use in validation of current and anticipated operations involving {sup 233}U at the Radiochemical Development Facility (RDF). This work was reported in ORNL/TM-2008/196 issued in January 2009. This paper presents the analysis of two representative safety analysis models provided by RDF staff.

In-Depth Analysis of Simulation Engine Codes for Comparison with DOE s Roof Savings Calculator and Measured Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

New, Joshua Ryan; Levinson, Ronnen; Huang, Yu

The Roof Savings Calculator (RSC) was developed through collaborations among Oak Ridge National Laboratory (ORNL), White Box Technologies, Lawrence Berkeley National Laboratory (LBNL), and the Environmental Protection Agency in the context of a California Energy Commission Public Interest Energy Research project to make cool-color roofing materials a market reality. The RSC website and a simulation engine validated against demonstration homes were developed to replace the liberal DOE Cool Roof Calculator and the conservative EPA Energy Star Roofing Calculator, which reported different roof savings estimates. A preliminary analysis arrived at a tentative explanation for why RSC results differed from previous LBNLmore » studies and provided guidance for future analysis in the comparison of four simulation programs (doe2attic, DOE-2.1E, EnergyPlus, and MicroPas), including heat exchange between the attic surfaces (principally the roof and ceiling) and the resulting heat flows through the ceiling to the building below. The results were consolidated in an ORNL technical report, ORNL/TM-2013/501. This report is an in-depth inter-comparison of four programs with detailed measured data from an experimental facility operated by ORNL in South Carolina in which different segments of the attic had different roof and attic systems.« less

Buried transuranic wastes at ORNL: Review of past estimates and reconciliation with current data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trabalka, J.R.

1997-09-01

Inventories of buried (generally meaning disposed of) transuranic (TRU) wastes at Oak Ridge National Laboratory (ORNL) have been estimated for site remediation and waste management planning over a period of about two decades. Estimates were required because of inadequate waste characterization and incomplete disposal records. For a variety of reasons, including changing definitions of TRU wastes, differing objectives for the estimates, and poor historical data, the published results have sometimes been in conflict. The purpose of this review was (1) to attempt to explain both the rationale for and differences among the various estimates, and (2) to update the estimatesmore » based on more recent information obtained from waste characterization and from evaluations of ORNL waste data bases and historical records. The latter included information obtained from an expert panel`s review and reconciliation of inconsistencies in data identified during preparation of the ORNL input for the third revision of the Baseline Inventory Report for the Waste Isolation Pilot Plant. The results summarize current understanding of the relationship between past estimates of buried TRU wastes and provide the most up-to-date information on recorded burials thereafter. The limitations of available information on the latter and thus the need for improved waste characterization are highlighted.« less

Limited transfer of long-term motion perceptual learning with double training.

PubMed

Liang, Ju; Zhou, Yifeng; Fahle, Manfred; Liu, Zili

2015-01-01

A significant recent development in visual perceptual learning research is the double training technique. With this technique, Xiao, Zhang, Wang, Klein, Levi, and Yu (2008) have found complete transfer in tasks that had previously been shown to be stimulus specific. The significance of this finding is that this technique has since been successful in all tasks tested, including motion direction discrimination. Here, we investigated whether or not this technique could generalize to longer-term learning, using the method of constant stimuli. Our task was learning to discriminate motion directions of random dots. The second leg of training was contrast discrimination along a new average direction of the same moving dots. We found that, although exposure of moving dots along a new direction facilitated motion direction discrimination, this partial transfer was far from complete. We conclude that, although perceptual learning is transferrable under certain conditions, stimulus specificity also remains an inherent characteristic of motion perceptual learning.

Field-emission from quantum-dot-in-perovskite solids

PubMed Central

García de Arquer, F. Pelayo; Gong, Xiwen; Sabatini, Randy P.; Liu, Min; Kim, Gi-Hwan; Sutherland, Brandon R.; Voznyy, Oleksandr; Xu, Jixian; Pang, Yuangjie; Hoogland, Sjoerd; Sinton, David; Sargent, Edward

2017-01-01

Quantum dot and well architectures are attractive for infrared optoelectronics, and have led to the realization of compelling light sensors. However, they require well-defined passivated interfaces and rapid charge transport, and this has restricted their efficient implementation to costly vacuum-epitaxially grown semiconductors. Here we report solution-processed, sensitive infrared field-emission photodetectors. Using quantum-dots-in-perovskite, we demonstrate the extraction of photocarriers via field emission, followed by the recirculation of photogenerated carriers. We use in operando ultrafast transient spectroscopy to sense bias-dependent photoemission and recapture in field-emission devices. The resultant photodiodes exploit the superior electronic transport properties of organometal halide perovskites, the quantum-size-tuned absorption of the colloidal quantum dots and their matched interface. These field-emission quantum-dot-in-perovskite photodiodes extend the perovskite response into the short-wavelength infrared and achieve measured specific detectivities that exceed 1012 Jones. The results pave the way towards novel functional photonic devices with applications in photovoltaics and light emission. PMID:28337981

Novel Quantum Dot Gate FETs and Nonvolatile Memories Using Lattice-Matched II-VI Gate Insulators

NASA Astrophysics Data System (ADS)

Jain, F. C.; Suarez, E.; Gogna, M.; Alamoody, F.; Butkiewicus, D.; Hohner, R.; Liaskas, T.; Karmakar, S.; Chan, P.-Y.; Miller, B.; Chandy, J.; Heller, E.

2009-08-01

This paper presents the successful use of ZnS/ZnMgS and other II-VI layers (lattice-matched or pseudomorphic) as high- k gate dielectrics in the fabrication of quantum dot (QD) gate Si field-effect transistors (FETs) and nonvolatile memory structures. Quantum dot gate FETs and nonvolatile memories have been fabricated in two basic configurations: (1) monodispersed cladded Ge nanocrystals (e.g., GeO x -cladded-Ge quantum dots) site-specifically self-assembled over the lattice-matched ZnMgS gate insulator in the channel region, and (2) ZnTe-ZnMgTe quantum dots formed by self-organization, using metalorganic chemical vapor-phase deposition (MOCVD), on ZnS-ZnMgS gate insulator layers grown epitaxially on Si substrates. Self-assembled GeO x -cladded Ge QD gate FETs, exhibiting three-state behavior, are also described. Preliminary results on InGaAs-on-InP FETs, using ZnMgSeTe/ZnSe gate insulator layers, are presented.

Relaxation of ferroelectric states in 2D distributions of quantum dots: EELS simulation

NASA Astrophysics Data System (ADS)

Cortés, C. M.; Meza-Montes, L.; Moctezuma, R. E.; Carrillo, J. L.

2016-06-01

The relaxation time of collective electronic states in a 2D distribution of quantum dots is investigated theoretically by simulating EELS experiments. From the numerical calculation of the probability of energy loss of an electron beam, traveling parallel to the distribution, it is possible to estimate the damping time of ferroelectric-like states. We generate this collective response of the distribution by introducing a mean field interaction among the quantum dots, and then, the model is extended incorporating effects of long-range correlations through a Bragg-Williams approximation. The behavior of the dielectric function, the energy loss function, and the relaxation time of ferroelectric-like states is then investigated as a function of the temperature of the distribution and the damping constant of the electronic states in the single quantum dots. The robustness of the trends and tendencies of our results indicate that this scheme of analysis can guide experimentalists to develop tailored quantum dots distributions for specific applications.

Electric transport through circular graphene quantum dots: Presence of disorder

NASA Astrophysics Data System (ADS)

Pal, G.; Apel, W.; Schweitzer, L.

2011-08-01

The electronic states of an electrostatically confined cylindrical graphene quantum dot and the electric transport through this device are studied theoretically within the continuum Dirac-equation approximation and compared with numerical results obtained from a tight-binding lattice description. A spectral gap, which may originate from strain effects, additional adsorbed atoms, or substrate-induced sublattice-symmetry breaking, allows for bound and scattering states. As long as the diameter of the dot is much larger than the lattice constant, the results of the continuum and the lattice model are in very good agreement. We also investigate the influence of a sloping dot-potential step, of on-site disorder along the sample edges, of uncorrelated short-range disorder potentials in the bulk, and of random magnetic fluxes that mimic ripple disorder. The quantum dot's spectral and transport properties depend crucially on the specific type of disorder. In general, the peaks in the density of bound states are broadened but remain sharp only in the case of edge disorder.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habercorn, Lasse; Merkl, Jan-Philip; Kloust, Hauke Christian

With the polymer encapsulation of quantum dots via seeded emulsion polymerization we present a powerful tool for the preparation of fluorescent nanoparticles with an extraordinary stability in aqueous solution. The method of the seeded emulsion polymerization allows a straightforward and simple in situ functionalization of the polymer shell under preserving the optical properties of the quantum dots. These requirements are inevitable for the application of semiconductor nanoparticles as markers for biomedical applications. Polymer encapsulated quantum dots have shown only a marginal loss of quantum yields when they were exposed to copper(II)-ions. Under normal conditions the quantum dots were totally quenchedmore » in presence of copper(II)-ions. Furthermore, a broad range of in situ functionalized polymer-coated quantum dots were obtained by addition of functional monomers or surfactants like fluorescent dye molecules, antibodies or specific DNA aptamers. Furthermore the emulsion polymerization can be used to prepare multifunctional hybrid systems, combining different nanoparticles within one construct without any adverse effect of the properties of the starting materials.{sup 1,2}.« less

Utilizing a CdTe quantum dots-enzyme hybrid system for the determination of both phenolic compounds and hydrogen peroxide.

PubMed

Yuan, Jipei; Guo, Weiwei; Wang, Erkang

2008-02-15

In this paper, we attempt to construct a simple and sensitive detection method for both phenolic compounds and hydrogen peroxide, with the successful combination of the unique property of quantum dots and the specificity of enzymatic reactions. In the presence of H2O2 and horseradish peroxidase, phenolic compounds can quench quantum dots' photoluminescence efficiently, and the extent of quenching is severalfold to more than 100-fold increase. Quinone intermediates produced from the enzymatic catalyzed oxidation of phenolic compounds were believed to play the main role in the photoluminescence quenching. Using a quantum dots-enzyme system, the detection limits for phenolic compounds and hydrogen peroxide were detected to be approximately 10(-7) mol L(-1). The coupling of efficient quenching of quantum dot photoluminescence by quinone and the effective enzymatic reactions make this a simple and sensitive method for phenolic compound detection and great potential in the development of H2O2 biosensors for various analytes.

PEER REVIEW FOR THE CONSUMER VEHICLE CHOICE ...

EPA Pesticide Factsheets

The U.S. Environmental Protection Agency’s (EPA) Office of Transportation and Air Quality (OTAQ) has recently sponsored the development of a Consumer Vehicle Choice Model (CVCM) by the Oak Ridge National Laboratory (ORNL). The specification by OTAQ to ORNL for consumer choice model development was to develop a Nested Multinomial Logit (NMNL) or other appropriate model capable of estimating the consumer surplus impacts and the sales mix effects of greenhouse gas (GHG) emission standards. The CVCM will use output from the EPA’s Optimization Model for reducing Emissions of Greenhouse gases from Automobiles (OMEGA), including changes in retail price equivalents, changes in fuel economy, and changes in emissions, to estimate these impacts. In addition, the CVCM will accept approximately 60 vehicle types, with the flexibility to function with fewer or more vehicle types, and will use a 15 year planning horizon, matching the OMEGA parameters. It will be calibrated to baseline sales projection data provided by the EPA and will include a buy/no-buy option to simulate the possibility that consumers will choose to keep their old vehicle or to buy a used vehicle. To support EPA's future assessment of potential light duty greenhouse gas standards

Reengineering of waste management at the Oak Ridge National Laboratory. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myrick, T.E.

1997-08-01

A reengineering evaluation of the waste management program at the Oak Ridge National Laboratory (ORNL) was conducted during the months of February through July 1997. The goal of the reengineering was to identify ways in which the waste management process could be streamlined and improved to reduce costs while maintaining full compliance and customer satisfaction. A Core Team conducted preliminary evaluations and determined that eight particular aspects of the ORNL waste management program warranted focused investigations during the reengineering. The eight areas included Pollution Prevention, Waste Characterization, Waste Certification/Verification, Hazardous/Mixed Waste Stream, Generator/WM Teaming, Reporting/Records, Disposal End Points, and On-Sitemore » Treatment/Storage. The Core Team commissioned and assembled Process Teams to conduct in-depth evaluations of each of these eight areas. The Core Team then evaluated the Process Team results and consolidated the 80 process-specific recommendations into 15 overall recommendations. Benchmarking of a commercial nuclear facility, a commercial research facility, and a DOE research facility was conducted to both validate the efficacy of these findings and seek additional ideas for improvement. The outcome of this evaluation is represented by the 15 final recommendations that are described in this report.« less

Data Sharing Report for the Quantification of Removable Activity in Various Surveillance and Maintenance Facilities at the Oak Ridge National Laboratory Oak Ridge TN

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, David A.

2013-12-12

The U.S. Department of Energy (DOE) Oak Ridge Office of Environmental Management (OR-EM) requested that Oak Ridge Associated Universities (ORAU), working under the Oak Ridge Institute for Science and Education (ORISE) contract, provide technical and independent waste management planning support using American Recovery and Reinvestment Act (ARRA) funds. Specifically, DOE OR-EM requested that ORAU plan and implement a sampling and analysis campaign targeting potential removable radiological contamination that may be transferrable to future personal protective equipment (PPE) and contamination control materials—collectively referred to as PPE throughout the remainder of this report—used in certain URS|CH2M Oak Ridge, LLC (UCOR) Surveillance andmore » Maintenance (S&M) Project facilities at the Oak Ridge National Laboratory (ORNL). Routine surveys in Bldgs. 3001, 3005, 3010, 3028, 3029, 3038, 3042, 3517, 4507, and 7500 continuously generate PPE. The waste is comprised of Tyvek coveralls, gloves, booties, Herculite, and other materials used to prevent worker exposure or the spread of contamination during routine maintenance and monitoring activities. This report describes the effort to collect and quantify removable activity that may be used by the ORNL S&M Project team to develop radiation instrumentation “screening criteria.” Material potentially containing removable activity was collected on smears, including both masselin large-area wipes (LAWs) and standard paper smears, and analyzed for site-related constituents (SRCs) in an analytical laboratory. The screening criteria, if approved, may be used to expedite waste disposition of relatively clean PPE. The ultimate objectives of this effort were to: 1) determine whether screening criteria can be developed for these facilities, and 2) provide process knowledge information for future site planners. The screening criteria, if calculated, must be formally approved by Federal Facility Agreement parties prior to use for ORNL S&M Project PPE disposal at the Environmental Management Waste Management Facility (EMWMF). ORAU executed the approved sampling and analysis plan (SAP) (DOE 2013) while closely coordinating with ORNL S&M Project personnel and using guidelines outlined in the Waste Handling Plan for Surveillance and Maintenance Activities at the Oak Ridge National Laboratory, DOE/OR/01-2565&D2 (WHP) (DOE 2012). WHP guidelines were followed because the PPE waste targeted by this SAP is consistent with that addressed under the approved Waste Lot (WL) 108.1 profile for disposal at EMWMF—this PPE is a “future waste stream” as defined in the WHP. The SAP presents sampling strategy and methodology, sample selection guidelines, and analytical guidelines and requirements necessary for characterizing future ORNL S&M Project PPE waste. This report presents a review of the sample and analysis methods including data quality objectives (DQOs), required deviations from the original design, summary of field activities, radiation measurement data, analytical laboratory results, a brief presentation of results, and process knowledge summaries.« less

A Case Study with Green Dot Public Schools on Managing the Tension between Fidelity and Adaptation When Scaling-Up

ERIC Educational Resources Information Center

Cevallos, Pedro F., Jr.

2009-01-01

This dissertation was a single case study with Green Dot Public Schools (GDPS) describing their rapid scale-up process. Specifically, it investigates the phenomenon of the inherent tension between maintaining the fidelity of the original model school's design, culture and values with local adaptation of the brand by stakeholders at the expansion…

A Case Study with Green Dot Public Schools on Managing the Tension between Fidelity and Adaptation when Scaling-Up

ERIC Educational Resources Information Center

Cevallos, Pedro Felipe, Jr.

2009-01-01

This dissertation was a single case study with Green Dot Public Schools (GDPS) describing their rapid scale-up process. Specifically, it investigates the phenomenon of the inherent tension between maintaining the fidelity of the original model school's design, culture and values with local adaptation of the brand by stakeholders at the expansion…

Quantum dots-based probes conjugated to Annexin V for photostable apoptosis detection and imaging

NASA Astrophysics Data System (ADS)

Le Gac, Séverine; Vermes, Istvan; van den Berg, Albert

2008-02-01

Quantum dots (Qdots) are nanoparticles exhibiting fluorescent properties that are widely applied for cell staining. We present here the development of quantum dots for specific targeting of apoptotic cells, for both apoptosis detection and staining of apoptotic "living" cells. These Qdots are functionalized with Annexin V, a 35-kDa protein that specifically interacts with the membrane of apoptotic cells: Annexin V recognizes and binds to phosphatidylserine (PS) moieties which are present on the outer membrane of apoptotic cells and not on this of healthy or necrotic cells. By using Annexin V, our Qdots probes are made specific for apoptotic cells. For that purpose, Qdots Streptavidin Conjugates are coupled to biotinylated Annexin V. Staining of apoptotic cells was checked using fluorescence and confocal microscopy techniques on nonfixed cells. It is shown here that Qdots are insensitive to bleaching after prolonged and frequent exposure as opposed to organic dyes and this makes them excellent candidates for time-lapse imaging purposes. We illustrate the application of our Qdots-based probes to continuously follow fast changes occurring on the membrane of apoptotic cells.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfiffner, Susan M.

Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), Florida State University (FSU), and the University of Tennessee. ORNL will serve as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project was initiated in November, 2004, in the Integrative Studies Element of the NABIR program. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

BIOME: A browser-aware search and order system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grubb, J.W.; Jennings, S.V.; Yow, T.G.

1996-05-01

The Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC), which is associated with NASA`s Earth Observing System Data and Information System (EOSDIS), provides access to a large number of tabular and imagery datasets used in ecological and environmental research. Because of its large and diverse data holdings, the challenge for the ORNL DAAC is to help users find data of interest from the hundreds of thousands of files available at the DAAC without overwhelming them. Therefore, the ORNL DAAC developed the Biogeochemical Information Ordering Management Environment (BIOME), a search and order system for the World Wide Web (WWW).more » The WWW provides a new vehicle that allows a wide range of users access to the data. This paper describes the specialized attributes incorporated into BIOME that allow researchers easy access to an otherwise bewildering array of data products.« less

Policies and practices pertaining to the selection, qualification requirements, and training programs for nuclear-reactor operating personnel at the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Culbert, W.H.

1985-10-01

This document describes the policies and practices of the Oak Ridge National Laboratory (ORNL) regarding the selection of and training requirements for reactor operating personnel at the Laboratory's nuclear-reactor facilities. The training programs, both for initial certification and for requalification, are described and provide the guidelines for ensuring that ORNL's research reactors are operated in a safe and reliable manner by qualified personnel. This document gives an overview of the reactor facilities and addresses the various qualifications, training, testing, and requalification requirements stipulated in DOE Order 5480.1A, Chapter VI (Safety of DOE-Owned Reactors); it is intended to be in compliancemore » with this DOE Order, as applicable to ORNL facilities. Included also are examples of the documentation maintained amenable for audit.« less

Fusion energy division annual progress report, period ending December 31, 1980

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-11-01

The ORNL Program encompasses most aspects of magnetic fusion research including research on two magnetic confinement programs (tokamaks and ELMO bumpy tori); the development of the essential technologies for plasma heating, fueling, superconducting magnets, and materials; the development of diagnostics; the development of atomic physics and radiation effect data bases; the assessment of the environmental impact of magnetic fusion; the physics and engineering of present-generation devices; and the design of future devices. The integration of all of these activities into one program is a major factor in the success of each activity. An excellent example of this integration is themore » extremely successful application of neutral injection heating systems developed at ORNL to tokamaks both in the Fusion Energy Division and at Princeton Plasma Physics Laboratory (PPPL). The goal of the ORNL Fusion Program is to maintain this balance between plasma confinement, technology, and engineering activities.« less

Fossil Energy Program Annual Progress Report for the Period April 1, 2000 through March 31, 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judkins, RR

This report covers progress made at Oak Ridge National Laboratory (ORNL) on research and development projects that contribute to the advancement of fossil energy technologies. Projects on the ORNL Fossil Energy Program are supported by the U.S. Department of Energy (DOE) Office of Fossil Energy, the DOE National Energy Technology Laboratory (NETL), the DOE Fossil Energy Clean Coal Technology (CCT) Program, the DOE National Petroleum Technology Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve (SPR). The ORNL Fossil Energy Program research and development activities cover the areas of coal, clean coal technology, gas, petroleum, and support tomore » the SPR. An important part of the Fossil Energy Program is technical management of all activities on the DOE Fossil Energy Advanced Research (AR) Materials Program. The AR Materials Program involves research at other DOE and government laboratories, at universities, and at industrial organizations.« less

Analysis of loss of decay-heat-removal sequences at Browns Ferry Unit One

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrington, R.M.

1983-01-01

This paper summarizes the Oak Ridge National Laboratory (ORNL) report Loss of DHR Sequences at Browns Ferry Unit One - Accident Sequence Analysis (NUREG/CR-2973). The Loss of DHR investigation is the third in a series of accident studies concerning the BWR 4 - MK I containment plant design. These studies, sponsored by the Nuclear Regulatory Commission Severe Accident Sequence Analysis (SASA) program, have been conducted at ORNL with the full cooperation of the Tennessee Valley Authority (TVA). The purpose of the SASA studies is to predetermine the probable course of postulated severe accidents so as to establish the timing andmore » the sequence of events. The SASA studies also produce recommendations concerning the implementation of better system design and better emergency operating instructions and operator training. The ORNL studies also include a detailed, best-estimate calculation of the release and transport of radioactive fission products following postulated severe accidents.« less

Development of a patient-specific dosimetry estimation system in nuclear medicine examination

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, H. H.; Dong, S. L.; Yang, H. J.

2011-07-01

The purpose of this study is to develop a patient-specific dosimetry estimation system in nuclear medicine examination using a SimSET-based Monte Carlo code. We added a dose deposition routine to store the deposited energy of the photons during their flights in SimSET and developed a user-friendly interface for reading PET and CT images. Dose calculated on ORNL phantom was used to validate the accuracy of this system. The S values for {sup 99m}Tc, {sup 18}F and {sup 131}I obtained by the system were compared to those from the MCNP4C code and OLINDA. The ratios of S values computed by thismore » system to those obtained with OLINDA for various organs were ranged from 0.93 to 1.18, which are comparable to that obtained from MCNP4C code (0.94 to 1.20). The average ratios of S value were 0.99{+-}0.04, 1.03{+-}0.05, and 1.00{+-}0.07 for isotopes {sup 131}I, {sup 18}F, and {sup 99m}Tc, respectively. The simulation time of SimSET was two times faster than MCNP4C's for various isotopes. A 3D dose calculation was also performed on a patient data set with PET/CT examination using this system. Results from the patient data showed that the estimated S values using this system differed slightly from those of OLINDA for ORNL phantom. In conclusion, this system can generate patient-specific dose distribution and display the isodose curves on top of the anatomic structure through a friendly graphic user interface. It may also provide a useful tool to establish an appropriate dose-reduction strategy to patients in nuclear medicine environments. (authors)« less

Comparison between DOT EIA IgM and Widal Test as early diagnosis of typhoid fever.

PubMed

Begum, Z; Hossain, M A; Musa, A K; Shamsuzzaman, A K; Mahmud, M C; Ahsan, M M; Sumona, A A; Ahmed, S; Jahan, N A; Alam, M; Begum, A

2009-01-01

A recently developed DOT enzyme immunoassay known as "Typhidot" for detecting IgM antibody against 50 KDa OMP antigen of Salmonella typhi, was evaluated on 100 clinically suspected typhoid fever cases and 40 age-sex matched controls, in the Department of Microbiology, Mymensingh Medical College during, the period from June 2006 to July 2007. Blood culture, Widal test, and DOT EIA for IgM test were performed in all patients. Among 100 clinically suspected typhoid fever cases, 35 were subsequently confirmed on the basis of positive blood culture for S. typhi and/or significant rising titre of Widal test. The DOT EIA IgM test could produce results within 1 hour. The result of the DOT EIA IgM test showed a good diagnostic value for typhoid fever. The sensitivity, specificity, positive and negative predictive value of the test was found as 91.42%, 90.00%, 88.88% and 92.30% respectively. On the other hand corresponding values for Widal test were of 42.85%, 85.00%, 71.42% and 62.96% respectively. Thus, The DOT EIA IgM seems to be a practical alternative to Widal test for early diagnosis of typhoid fever.

The effect of precursor on the optical properties of carbon quantum dots synthesized by hydrothermal/solvothermal method

NASA Astrophysics Data System (ADS)

Mozdbar, Afsaneh; Nouralishahi, Amideddin; Fatemi, Shohreh; Mirakhori, Ghazaleh

2018-01-01

In the recent decade, Carbon Quantum Dots (CQDs) have attracted lots of attention due to their excellent properties such as tunable photoluminescence, high chemical stability, low toxicity, and biocompatibility. Among all synthesis methods, the hydrothermal/solvothermal rout has been considered as one of the most common and simplest method. The type of precursors can affect the size of CQDs and determine their surface functional groups, the essential properties that deeply influence the optical specifications. In this work, the effect of different precursors on the final properties of carbon quantum dots is investigated. The carbon quantum dots were synthesized by hydrothermal/solvothermal rout using citric acid, thiourea, ethylamine and monoethanolamine as precursors in almost the same conditions of time and temperature. Resultant CQDs were characterized by using FTIR, UV-Visible Spectroscopy and Photoluminescence (PL) analysis. The results of UV-Vis spectroscopy showed that quantum dots synthesized from monoethanolamine have wider absorption band rather than the CQDs from other precursors and the absorption edge shifted from about 270 nm for ethylamine to about 470 nm in monoethanolamine. Furthermore, the results demonstrate that using citric acid and monoethanolamine as precursor improved production efficiency and emission quantum yield of the carbon dots.

Perceptual asymmetry reveals neural substrates underlying stereoscopic transparency.

PubMed

Tsirlin, Inna; Allison, Robert S; Wilcox, Laurie M

2012-02-01

We describe a perceptual asymmetry found in stereoscopic perception of overlaid random-dot surfaces. Specifically, the minimum separation in depth needed to perceptually segregate two overlaid surfaces depended on the distribution of dots across the surfaces. With the total dot density fixed, significantly larger inter-plane disparities were required for perceptual segregation of the surfaces when the front surface had fewer dots than the back surface compared to when the back surface was the one with fewer dots. We propose that our results reflect an asymmetry in the signal strength of the front and back surfaces due to the assignment of the spaces between the dots to the back surface by disparity interpolation. This hypothesis was supported by the results of two experiments designed to reduce the imbalance in the neuronal response to the two surfaces. We modeled the psychophysical data with a network of inter-neural connections: excitatory within-disparity and inhibitory across disparity, where the spread of disparity was modulated according to figure-ground assignment. These psychophysical and computational findings suggest that stereoscopic transparency depends on both inter-neural interactions of disparity-tuned cells and higher-level processes governing figure ground segregation. Copyright © 2011 Elsevier Ltd. All rights reserved.

A Quick and Parallel Analytical Method Based on Quantum Dots Labeling for ToRCH-Related Antibodies

NASA Astrophysics Data System (ADS)

Yang, Hao; Guo, Qing; He, Rong; Li, Ding; Zhang, Xueqing; Bao, Chenchen; Hu, Hengyao; Cui, Daxiang

2009-12-01

Quantum dot is a special kind of nanomaterial composed of periodic groups of II-VI, III-V or IV-VI materials. Their high quantum yield, broad absorption with narrow photoluminescence spectra and high resistance to photobleaching, make them become a promising labeling substance in biological analysis. Here, we report a quick and parallel analytical method based on quantum dots for ToRCH-related antibodies including Toxoplasma gondii, Rubella virus, Cytomegalovirus and Herpes simplex virus type 1 (HSV1) and 2 (HSV2). Firstly, we fabricated the microarrays with the five kinds of ToRCH-related antigens and used CdTe quantum dots to label secondary antibody and then analyzed 100 specimens of randomly selected clinical sera from obstetric outpatients. The currently prevalent enzyme-linked immunosorbent assay (ELISA) kits were considered as “golden standard” for comparison. The results show that the quantum dots labeling-based ToRCH microarrays have comparable sensitivity and specificity with ELISA. Besides, the microarrays hold distinct advantages over ELISA test format in detection time, cost, operation and signal stability. Validated by the clinical assay, our quantum dots-based ToRCH microarrays have great potential in the detection of ToRCH-related pathogens.

[GM1-dot-EIA for the detection of toxin-producing Vibrio cholerae strains].

PubMed

Markina, O V; Alekseeva, L P; Telesmanich, N R; Chemisova, O S; Akulova, M V; Markin, N V

2011-05-01

A new variant of enzyme immunoassay (EIA) has been developed on the basis of GM1 gangliosides to detect the toxin-producing Vibrio cholerae strains--GM1-dot-EIA. Experiments were run using a nitrocellulose membrane to bind GM1 gangliosides and polyclonal antitoxic serum to detect cholerogen. GM1-dot-EIA testing identified cholera toxin in 11 of 13 supernatants of V. cholerae eltor ctx(+) strains isolated from man and in 3 of 7 supernatants of V. cholerae eltor ctx(+) strains isolated from water. These data agree with those obtained in CM1-EIA. There was no reaction with the supernatants of other microorganisms. The sensitivity of the technique was 10 ng/ml. Thus, the simple and specific GM1-dot-EIA may be recommended to detect toxin-producing V cholerae strains isolated from man and water.

Temperature independent infrared responsivity of a quantum dot quantum cascade photodetector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Feng-Jiao; Zhuo, Ning; Liu, Shu-Man, E-mail: liusm@semi.ac.cn

2016-06-20

We demonstrate a quantum dot quantum cascade photodetector with a hybrid active region of InAs quantum dots and an InGaAs quantum well, which exhibited a temperature independent response at 4.5 μm. The normal incident responsivity reached 10.3 mA/W at 120 K and maintained a value of 9 mA/W up to 260 K. It exhibited a specific detectivity above 10{sup 11} cm Hz{sup 1/2} W{sup −1} at 77 K, which remained at 10{sup 8} cm Hz{sup 1/2} W{sup −1} at 260 K. We ascribe the device's good thermal stability of infrared response to the three-dimensional quantum confinement of the InAs quantum dots incorporated in the active region.

MCNPX CALCULATIONS OF SPECIFIC ABSORBED FRACTIONS IN SOME ORGANS OF THE HUMAN BODY DUE TO APPLICATION OF 133Xe, 99mTc and 81mKr RADIONUCLIDES.

PubMed

Jovanovic, Z; Krstic, D; Nikezic, D; Ros, J M Gomez; Ferrari, P

2018-03-01

Monte Carlo simulations were performed to evaluate treatment doses with wide spread used radionuclides 133Xe, 99mTc and 81mKr. These different radionuclides are used in perfusion or ventilation examinations in nuclear medicine and as indicators for cardiovascular and pulmonary diseases. The objective of this work was to estimate the specific absorbed fractions in surrounding organs and tissues, when these radionuclides are incorporated in the lungs. For this purpose a voxel thorax model has been developed and compared with the ORNL phantom. All calculations and simulations were performed by means of the MCNP5/X code.

Tuning direct bandgap GeSn/Ge quantum dots' interband and intraband useful emission wavelength: Towards CMOS compatible infrared optical devices

NASA Astrophysics Data System (ADS)

Baira, Mourad; Salem, Bassem; Madhar, Niyaz Ahamad; Ilahi, Bouraoui

2018-05-01

In this work, interband and intraband optical transitions from direct bandgap strained GeSn/Ge quantum dots are numerically tuned by evaluating the confined energies for heavy holes and electrons in D- and L-valley. The practically exploitable emission wavelength ranges for efficient use in light emission and sensing should fulfill specific criteria imposing the electrons confined states in D-valley to be sufficiently below those in L-valley. This study shows that GeSn quantum dots offer promising opportunity towards high efficient group IV based infrared optical devices operating in the mid-IR and far-IR wavelength regions.

Mitigation of Quantum Dot Cytotoxicity by Microencapsulation

PubMed Central

Romoser, Amelia; Ritter, Dustin; Majitha, Ravish; Meissner, Kenith E.; McShane, Michael; Sayes, Christie M.

2011-01-01

When CdSe/ZnS-polyethyleneimine (PEI) quantum dots (QDs) are microencapsulated in polymeric microcapsules, human fibroblasts are protected from acute cytotoxic effects. Differences in cellular morphology, uptake, and viability were assessed after treatment with either microencapsulated or unencapsulated dots. Specifically, QDs contained in microcapsules terminated with polyethylene glycol (PEG) mitigate contact with and uptake by cells, thus providing a tool to retain particle luminescence for applications such as extracellular sensing and imaging. The microcapsule serves as the “first line of defense” for containing the QDs. This enables the individual QD coating to be designed primarily to enhance the function of the biosensor. PMID:21814567

49 CFR 179.400-21 - Test of pressure relief valves.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and...

49 CFR 179.100-17 - Closures for openings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100...

THE CRYSTALLOGRAPHIC INVESTIGATION OF AuCl /center dot/ PCl$sub 3$ AND IBOGAINE /center dot/ HBr

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arai-wessel, G.J.

1960-01-01

The structure of the two compounds is completely dlfferent, one being an inorganic complex and the other being an organic alkaloid complex. The difference in crystal constitution caused a difference in behavior with regard to radiation, requiring the use of specific crysthllographic methods for each. Interferences involved in determining their crystal structure are compared and discussed. (N.W.R.)

Usefulness of in-house obtained recombinant proteins Yop of Yersinia enterocolitica as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis.

PubMed

Rastawicki, Waldemar; Smietafiska, Karolina; Chrost, Anna; Wolkowicz, Tomasz; Rokosz-Chudziak, Natalia

Proper analysis of the human immune response is crucial in the laboratory diagnosis of many bacterial infections-The current serological diagnosis of yersiniosis often is carried out using ELISA with native antigens. However, recombinant proteins increase the specificity of the serological assays, particularly in patients with chronic, non- specific infections. The aim of the present study was to evaluate the usefulness of in-house obtained recombinant proteins Yop of Yersinia enterocolitica as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis. Recombinant YopD, YopB, YopE and V-Ag proteins of Y enterocolitica were expressing in E. coli BL21 (DE3) using the pET-30 Ek/LIC expression vector (Novagen). Purification was accomplished by immobilized metal (Ni2) affinity column chromatography (His-trap). The proteins were used as antigens in standard ELISA and recom-dot assay, which was performed on nitrocellulose strips. The study population, used for characterization of the humoral immune response to the recombinant proteins, consisted of 74 patients suspected for Y enterocolitica infection and 41 clinically healthy blood donors. Some of the results obtained by ELISA and recom-dot were compared with results obtained by commercial western-blot Yersinia (Virotech). In the group of patients suspected for yersiniosis in clinical investigation the most positive results were obtained in ELISA with the recombinant protein YopD (IgA respectively 25 (42.4%), IgG 41 (69.5%), IgM 24 (40.7%). The percentage ofpositive results in the group of blood donors did not exceed 10.0% in IgG and 5.0% in IgA/IgM classes of immunoglobulin. The results obtained in the recom-dot assay showed that among 74 tested serum samples obtained from individuals suspected of yersiniosis the most common IgA, IgG and IgM antibodies were found for recombinant protein YopD (respectively IgG in 60.8%, IgA in 37.8% and IgM in 33.8% of serum samples). IgG antibodies to the protein V-Ag were observed in 32.4%, protein YopB in 27.0% and for the protein YopE in 18.9% serum samples. Immunoglobulin A, and M for the recombinant proteins were found much less frequently than IgG antibodies (respectively 12.2% and 10.8% for V protein-Ag in 10.8% and 14.9% protein and_YopB 2,7% and 10.8% for the protein YopE). Further studies showed that results obtained in recom-dot assay with recombinant protein YopD were comparable with the results of commercial western-blot Yersinia. The study showed that in-house obtained recombinant proteins can be used as highly specific antigens in ELISA and recom-dot performed in the serodiagnosis of yersiniosis. The most useful was the protein YopD.

Qualifying Items of Work for End-Result Specifications

DOT National Transportation Integrated Search

1997-07-01

The Texas Department of Transportation (TxDOT) is presently using a performance-based specification for hot-mix asphalt concrete pavement. There is a strong interest in determining if other construction items can be converted into this type of specif...

Chemically Triggered Formation of Two-Dimensional Epitaxial Quantum Dot Superlattices.

PubMed

Walravens, Willem; De Roo, Jonathan; Drijvers, Emile; Ten Brinck, Stephanie; Solano, Eduardo; Dendooven, Jolien; Detavernier, Christophe; Infante, Ivan; Hens, Zeger

2016-07-26

Two dimensional superlattices of epitaxially connected quantum dots enable size-quantization effects to be combined with high charge carrier mobilities, an essential prerequisite for highly performing QD devices based on charge transport. Here, we demonstrate that surface active additives known to restore nanocrystal stoichiometry can trigger the formation of epitaxial superlattices of PbSe and PbS quantum dots. More specifically, we show that both chalcogen-adding (sodium sulfide) and lead oleate displacing (amines) additives induce small area epitaxial superlattices of PbSe quantum dots. In the latter case, the amine basicity is a sensitive handle to tune the superlattice symmetry, with strong and weak bases yielding pseudohexagonal or quasi-square lattices, respectively. Through density functional theory calculations and in situ titrations monitored by nuclear magnetic resonance spectroscopy, we link this observation to the concomitantly different coordination enthalpy and ligand displacement potency of the amine. Next to that, an initial ∼10% reduction of the initial ligand density prior to monolayer formation and addition of a mild, lead oleate displacing chemical trigger such as aniline proved key to induce square superlattices with long-range, square micrometer order; an effect that is the more pronounced the larger the quantum dots. Because the approach applies to PbS quantum dots as well, we conclude that it offers a reproducible and rational method for the formation of highly ordered epitaxial quantum dot superlattices.

Application of quantum-dots for analysis of nanosystems by either utilizing or preventing FRET

NASA Astrophysics Data System (ADS)

Kim, Joong H.; Chaudhary, Sumit; Stephens, Jared P.; Singh, Krishna V.; Ozkan, Mihrimah

2005-04-01

We have developed conjugates with quantum-dots (QDs) for the purpose of analysis of nanosystems that are organic or inorganic in nature such as DNA and carbon nanotubes. First, by employing Florescence Resonant Energy Transfer (FRET) principles, a hybrid molecular beacon conjugates are synthesized. For water- solubilization of QDs, we modified the surface of CdSe-ZnS core-shell QD by using mercaptoacetic acid ligand. This modification does not affect the size of QDs from that of unmodified QDs. After linking molecular beacons to the carboxyl groups of the modified QDs using 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride, hybrid molecular beacons are prepared as a DNA probe. After hybridization with specific target DNA and non-specific target DNA, the hybrid conjugates show high specificity to the target DNA with 5-fold increase in the intensity of fluorescence. By developing atomic model of the conjugates, we calculated with 8 numbers of molecular beacons on a single quantum dots, we could increase the efficiency of FRET up to 90%. In other hands, for application of quantum dots to the carbon nanotubes, FRET is a barrier. Thus, after employing 1 % sodium-dodecyl-sulfonate (SDS), single-walled carbon nanotubes are decorated with QDs at their outer surface. This enables fluorescent microscopy imaging of single-walled carbon nanotubes which is a more common technique than electron microscopy. In summary, QDs can be used for analysis or detection of both organic and inorganic based nanosystems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kostka, Joel E.

Summary of Results to Date: Our current research represents a joint effort between Oak Ridge National Laboratory (ORNL), Florida State University (FSU), and the University of Tennessee. ORNL will serve as the lead institution with Dr. A.V. Palumbo responsible for project coordination, integration, and deliverables. This project was initiated in November, 2004, in the Integrative Studies Element of the NABIR program. The overall goal of our project is to provide an improved understanding of the relationships between microbial community structure, geochemistry, and metal reduction rates.

Cincinnati Big Area Additive Manufacturing (BAAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duty, Chad E.; Love, Lonnie J.

Oak Ridge National Laboratory (ORNL) worked with Cincinnati Incorporated (CI) to demonstrate Big Area Additive Manufacturing which increases the speed of the additive manufacturing (AM) process by over 1000X, increases the size of parts by over 10X and shows a cost reduction of over 100X. ORNL worked with CI to transition the Big Area Additive Manufacturing (BAAM) technology from a proof-of-principle (TRL 2-3) demonstration to a prototype product stage (TRL 7-8).

HAZWOPER work plan and site safety and health plan for the Alpha characterization project at the solid waste storage area 4 bathtubbing trench at Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-07-01

This work plan/site safety and health plan is for the alpha sampling project at the Solid Waste Storage Area 4 bathtubbing trench. The work will be conducted by the Oak Ridge National Laboratory (ORNL) Environmental Sciences Division and associated ORNL environmental, safety, and health support groups. This activity will fall under the scope of 29 CFR 1910.120, Hazardous Waste Operations and Emergency Response (HAZWOPER). The purpose of this document is to establish health and safety guidelines to be followed by all personnel involved in conducting work for this project. Work will be conducted in accordance with requirements as stipulated inmore » the ORNL HAZWOPER Program Manual and applicable ORNL; Martin Marietta Energy Systems, Inc.; and U.S. Department of Energy policies and procedures. The levels of protection and the procedures specified in this plan are based on the best information available from historical data and preliminary evaluations of the area. Therefore, these recommendations represent the minimum health and safety requirements to be observed by all personnel engaged in this project. Unforeseeable site conditions or changes in scope of work may warrant a reassessment of the stated protection levels and controls. All adjustments to the plan must have prior approval by the safety and health disciplines signing the original plan.« less

49 CFR 179.200-21 - Closures for openings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-21...

49 CFR 179.200-15 - Closures for manways.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-15...

Mn/DOT combined smoothness specification.

DOT National Transportation Integrated Search

2010-04-01

This report presents the development of a combined smoothness specification for asphalt and concrete pavements : and associated training for the certification of profiler operators by highway agencies. The report discusses the : analyses conducted to...

49 CFR 179.100-17 - Closures for openings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-17 Closures for...

49 CFR 179.100-17 - Closures for openings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-17 Closures for...

49 CFR 179.100-17 - Closures for openings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-17 Closures for...

Base compaction specification feasibility analysis.

DOT National Transportation Integrated Search

2012-12-01

The objective of this research is to establish the technical engineering and cost : analysis concepts that will enable WisDOT management to objectively evaluate the : feasibility of switching construction specification philosophies for aggregate base...

Develop a Methodology to Evaluate the Effectiveness of QC/QA Specifications (Phase II)

DOT National Transportation Integrated Search

1998-08-01

The Texas Department of Transportation (TxDOT) has been implementing statistically based quality control/quality assurance (QC/QA) specifications for hot mix asphalt concrete pavements since the early 1990s. These specifications have been continuousl...

Additively Manufactured, Net Shape Powder Metallurgy Cans for Valves Used in Energy Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peter, William H.; Gandy, David; Lannom, Robert

This CRADA NFE-14-05241 was conducted as a Technical Collaboration project within the Oak Ridge National Laboratory (ORNL) Manufacturing Demonstration Facility (MDF) sponsored by the US Department of Energy Advanced Manufacturing Office (CPS Agreement Number 24761). Opportunities for MDF technical collaborations are listed in the announcement “Manufacturing Demonstration Facility Technology Collaborations for US Manufacturers in Advanced Manufacturing and Materials Technologies” posted at http://web.ornl.gov/sci/manufacturing/docs/FBO-ORNL-MDF-2013-2.pdf. The goal of technical collaborations is to engage industry partners to participate in short-term, collaborative projects within the Manufacturing Demonstration Facility (MDF) to assess applicability and of new energy efficient manufacturing technologies. Research sponsored by the U.S. Departmentmore » of Energy, Office of Energy Efficiency and Renewable Energy, Advanced Manufacturing Office, under contract DE-AC05-00OR22725 with UT-Battelle, LLC.ORNL would like to acknowledge the leadership of EPRI in pulling together the extensive team and managing the execution of the project. In addition, ORNL would like to acknowledge the other contributions of the team members associated with this project. Quintus provided time, access, expertise, and labor of their hydro forming capabilities to evaluate both conventional and additively manufactured tools through this process. Crane ChemPharma Energy provided guidance and information on valve geometries. Carpenter Powder Products was involved with the team providing information on powder processing as it pertains to the canning and hot isostatic pressing of powder. on providing powder and knowledge as it pertains to powder supply for hot isostatic pressing; they also provided powder for the test trials by the industrial team. Bodycote provided guidance on hot isostatic pressing and can requirements. They were also responsible for the hot isostatic pressing of the test valve performed by the industrial team.« less

ORNL Pre-test Analyses of A Large-scale Experiment in STYLE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Paul T; Yin, Shengjun; Klasky, Hilda B

Oak Ridge National Laboratory (ORNL) is conducting a series of numerical analyses to simulate a large scale mock-up experiment planned within the European Network for Structural Integrity for Lifetime Management non-RPV Components (STYLE). STYLE is a European cooperative effort to assess the structural integrity of (non-reactor pressure vessel) reactor coolant pressure boundary components relevant to ageing and life-time management and to integrate the knowledge created in the project into mainstream nuclear industry assessment codes. ORNL contributes work-in-kind support to STYLE Work Package 2 (Numerical Analysis/Advanced Tools) and Work Package 3 (Engineering Assessment Methods/LBB Analyses). This paper summarizes the current statusmore » of ORNL analyses of the STYLE Mock-Up3 large-scale experiment to simulate and evaluate crack growth in a cladded ferritic pipe. The analyses are being performed in two parts. In the first part, advanced fracture mechanics models are being developed and performed to evaluate several experiment designs taking into account the capabilities of the test facility while satisfying the test objectives. Then these advanced fracture mechanics models will be utilized to simulate the crack growth in the large scale mock-up test. For the second part, the recently developed ORNL SIAM-PFM open-source, cross-platform, probabilistic computational tool will be used to generate an alternative assessment for comparison with the advanced fracture mechanics model results. The SIAM-PFM probabilistic analysis of the Mock-Up3 experiment will utilize fracture modules that are installed into a general probabilistic framework. The probabilistic results of the Mock-Up3 experiment obtained from SIAM-PFM will be compared to those results generated using the deterministic 3D nonlinear finite-element modeling approach. The objective of the probabilistic analysis is to provide uncertainty bounds that will assist in assessing the more detailed 3D finite-element solutions and to also assess the level of confidence that can be placed in the best-estimate finiteelement solutions.« less

Model of rotary-actuated flexible beam with notch filter vibration suppression controller and torque feedforward load compensation controller

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bills, K.C.; Kress, R.L.; Kwon, D.S.

1994-12-31

This paper describes ORNL`s development of an environment for the simulation of robotic manipulators. Simulation includes the modeling of kinematics, dynamics, sensors, actuators, control systems, operators, and environments. Models will be used for manipulator design, proposal evaluation, control system design and analysis, graphical preview of proposed motions, safety system development, and training. Of particular interest is the development of models for robotic manipulators having at least one flexible link. As a first application, models have been developed for the Pacific Northwest Laboratory`s Flexible Beam Test Bed (PNL FBTB), which is a 1-Degree-of-Freedom, flexible arm with a hydraulic base actuator. ORNLmore » transferred control algorithms developed for the PNL FBTB to controlling IGRIP models. A robust notch filter is running in IGRIP controlling a full dynamics model of the PNL test bed. Model results provide a reasonable match to the experimental results (quantitative results are being determined) and can run on ORNL`s Onyx machine in approximately realtime. The flexible beam is modeled as six rigid sections with torsional springs between each segment. The spring constants were adjusted to match the physical response of the flexible beam model to the experimental results. The controller is able to improve performance on the model similar to the improvement seen on the experimental system. Some differences are apparent, most notably because the IGRIP model presently uses a different trajectory planner than the one used by ORNL on the PNL test bed. In the future, the trajectory planner will be modified so that the experiments and models are the same. The successful completion of this work provides the ability to link C code with IGRIP, thus allowing controllers to be developed, tested, and tuned in simulation and then ported directly to hardware systems using the C language.« less

SkyDOT: a publicly accessible variability database, containing multiple sky surveys and real-time data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Starr, D. L.; Wozniak, P. R.; Vestrand, W. T.

2002-01-01

SkyDOT (Sky Database for Objects in Time-Domain) is a Virtual Observatory currently comprised of data from the RAPTOR, ROTSE I, and OGLE I1 survey projects. This makes it a very large time domain database. In addition, the RAPTOR project provides SkyDOT with real-time variability data as well as stereoscopic information. With its web interface, we believe SkyDOT will be a very useful tool for both astronomers, and the public. Our main task has been to construct an efficient relational database containing all existing data, while handling a real-time inflow of data. We also provide a useful web interface allowing easymore » access to both astronomers and the public. Initially, this server will allow common searches, specific queries, and access to light curves. In the future we will include machine learning classification tools and access to spectral information.« less

49 CFR 179.100 - General specifications applicable to pressure tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... car tanks. 179.100 Section 179.100 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100 General specifications applicable to pressure tank car tanks. ...

49 CFR 179.100 - General specifications applicable to pressure tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... car tanks. 179.100 Section 179.100 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100 General specifications applicable to pressure tank car tanks. ...

49 CFR 179.100 - General specifications applicable to pressure tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... car tanks. 179.100 Section 179.100 Transportation Other Regulations Relating to Transportation... REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100 General specifications applicable to pressure tank car tanks. ...

49 CFR 179.100 - General specifications applicable to pressure tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... car tanks. 179.100 Section 179.100 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100 General specifications applicable to pressure tank car tanks. ...

Quantum dot-fluorescence in situ hybridisation for Ectromelia virus detection based on biotin-streptavidin interactions.

PubMed

Wang, Ting; Zheng, Zhenhua; Zhang, Xian-En; Wang, Hanzhong

2016-09-01

Ectromelia virus (ECTV) is an pathogen that can lead to a lethal, acute toxic disease known as mousepox in mice. Prevention and control of ECTV infection requires the establishment of a rapid and sensitive diagnostic system for detecting the virus. In the present study, we developed a method of quantum-dot-fluorescence based in situ hybridisation for detecting ECTV genome DNA. Using biotin-dUTP to replace dTTP, biotin was incorporated into a DNA probe during polymerase chain reaction. High sensitivity and specificity of ECTV DNA detection were displayed by fluorescent quantum dots based on biotin-streptavidin interactions. ECTV DNA was then detected by streptavidin-conjugated quantum dots that bound the biotin-labelled probe. Results indicated that the established method can visualise ECTV genomic DNA in both infected cells and mouse tissues. To our knowledge, this is the first study reporting quantum-dot-fluorescence based in situ hybridisation for the detection of viral nucleic acids, providing a reference for the identification and detection of other viruses. Copyright © 2016. Published by Elsevier B.V.

Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

NASA Astrophysics Data System (ADS)

Zimmermann, Bernhard B.; Deng, Bin; Singh, Bhawana; Martino, Mark; Selb, Juliette; Fang, Qianqian; Sajjadi, Amir Y.; Cormier, Jayne; Moore, Richard H.; Kopans, Daniel B.; Boas, David A.; Saksena, Mansi A.; Carp, Stefan A.

2017-04-01

Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (up to 1 Hz) image acquisition rate to enable tracking hemodynamic changes induced by the mammographic breast compression. The system integrates 96 continuous-wave and 24 frequency-domain source locations as well as 32 continuous wave and 20 frequency-domain detection locations into low-profile plastic plates that can easily mate to the DBT compression paddle and x-ray detector cover, respectively. We demonstrate system performance using static and dynamic tissue-like phantoms as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.

Integrated photonics using colloidal quantum dots

NASA Astrophysics Data System (ADS)

Menon, Vinod M.; Husaini, Saima; Okoye, Nicky; Valappil, Nikesh V.

2009-11-01

Integrated photonic devices were realized using colloidal quantum dot composites such as flexible microcavity laser, microdisk emitters and integrated active-passive waveguides. The microcavity laser structure was realized using spin coating and consisted of an all-polymer distributed Bragg reflector with a poly-vinyl carbazole cavity layer embedded with InGaP/ZnS colloidal quantum dots. These microcavities can be peeled off the substrate yielding a flexible structure that can conform to any shape and whose emission spectra can be mechanically tuned. Planar photonic devices consisting of vertically coupled microring resonators, microdisk emitters, active-passive integrated waveguide structures and coupled active microdisk resonators were realized using soft lithography, photo-lithography, and electron beam lithography, respectively. The gain medium in all these devices was a composite consisting of quantum dots embedded in SU8 matrix. Finally, the effect of the host matrix on the optical properties of the quantum dots using results of steady-state and time-resolved luminescence measurements was determined. In addition to their specific functionalities, these novel device demonstrations and their development present a low-cost alternative to the traditional photonic device fabrication techniques.

Exchange-dominated eigenmodes in sub-100 nm permalloy dots: A micromagnetic study at finite temperature

NASA Astrophysics Data System (ADS)

Carlotti, G.; Gubbiotti, G.; Madami, M.; Tacchi, S.; Stamps, R. L.

2014-05-01

Micromagnetic simulations at room temperature (300 K) have been carried out in order to analyse the magnetic eigenmodes (frequency and spatial profile) in elliptical dots with sub-100 nm lateral size. Features are found that are qualitatively different from those typical of larger dots because of the dominant role played by the exchange-energy. These features can be understood most simply in terms of nodal planes defined relative to the orientation of the static magnetization. A new, generalized labeling scheme is proposed that simplifies discussion and comparison of modes from different geometries. It is shown that the lowest-frequency mode for small dots is characterized by an in-phase precession of spins, without nodal planes, but with a maximum amplitude at the edges. This mode softens at an applied switching field with magnitude comparable to the coercive field and determines specific aspects of magnetization reversal. This characteristic behavior can be relevant for optimization of microwave assisting switching as well as for maximizing interdot coupling in dense arrays of dots.

49 CFR 179.300-14 - Attachments not otherwise specified.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-14 Attachments...

49 CFR 179.220-22 - Closure for openings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220-22 Closure for openings...

49 CFR 179.200-21 - Closures for openings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-21 Closures for openings...

49 CFR 179.220-20 - Reinforcements, when used, and appurtenances not otherwise specified.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

49 CFR 179.201-5 - Postweld heat treatment and corrosion resistance.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179...

49 CFR 179.201-8 - Sampling device and thermometer well.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-8 Sampling...

49 CFR 179.220-22 - Closure for openings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220-22 Closure for openings...

49 CFR 179.201-8 - Sampling device and thermometer well.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-8 Sampling...

49 CFR 179.201-5 - Postweld heat treatment and corrosion resistance.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179...

49 CFR 179.300-3 - Type and general requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-3 Type and...

49 CFR 179.300-12 - Protection of fittings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-12 Protection of fittings. (a...

49 CFR 179.201-8 - Sampling device and thermometer well.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-8 Sampling...

49 CFR 179.200-21 - Closures for openings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-21 Closures for openings...

49 CFR 179.200-15 - Closures for manways.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-15 Closures for manways...

49 CFR 179.200-21 - Closures for openings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-21 Closures for openings...

49 CFR 179.300-12 - Protection of fittings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-12 Protection of fittings. (a...

49 CFR 179.201-5 - Postweld heat treatment and corrosion resistance.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179...

49 CFR 179.200-19 - Reinforcements, when used, and appurtenances not otherwise specified.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200...

49 CFR 179.220-13 - Inner container manway nozzle and cover.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179...

49 CFR 179.200-15 - Closures for manways.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-15 Closures for manways...

49 CFR 179.201-8 - Sampling device and thermometer well.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-8...

49 CFR 179.200-19 - Reinforcements, when used, and appurtenances not otherwise specified.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

49 CFR 179.200-15 - Closures for manways.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-15 Closures for manways...

49 CFR 179.200-19 - Reinforcements, when used, and appurtenances not otherwise specified.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW...

Test report dot7A type A liquid packaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ketusky, E. T.; Brandjes, C.; Benoit, T. J.

2017-09-19

This section presents a general description of the DOT Specification 7A Type A liquid content packaging (HVYTAL), the liquid content evaluated as its payload, acceptable payload shipping configurations and features special to its use. This test report documents compliance with the regulatory safety requirements of 49 CFR Parts 173.24, 173.24a, 173.27, 173.410, 173.412, 173.461 – 173.466 and 178.350.

One-pot hydrothermal synthesis of ZnS quantum dots/graphene hybrids as a dual anode for sodium ion and lithium ion batteries

NASA Astrophysics Data System (ADS)

Zhang, Rupeng; Wang, Yu; Jia, Mengqiu; Xu, Junjie; Pan, Erzhuang

2018-04-01

Committed to research high-performance sodium-ion batteries(SIBs) and lithium-ion batteries(LIBs) anode materials is attractive but challenging. Among the many promising anode materials, sulfides are considered as promising available anode material. In this paper, we successfully synthesized uniformly dispersed ZnS quantum dots (QDs) with sub-10-nm-scale on graphene nanosheets via a facile hydrothermal method. The prepared ZnS/graphene composites was studied as a dual anode for sodium-ion and lithium-ion batteries. Tested against SIBs, the nanocomposites exhibits an impressive specific capacity of 491 mAh/g at 100 mA/g after 100 cycles. Tested against LIBs, the nanocomposites delivers a superior specific capacity of 759 mAh/g at 100 mA/g after 100 cycles. This excellent performance is mainly due to the fact that graphene can improve the conductivity of the composites and effectively prevent the agglomeration and pulverization of ZnS quantum dots during cycling. Meanwhile, ZnS quantum dots with sub-10-nm-scale may also shorten diffuse path and reduce migration barrier, which is in favor of the full utilization of the active material and the improvement of the stability of the structure

Ratio abstraction over discrete magnitudes by newly hatched domestic chicks (Gallus gallus).

PubMed

Rugani, Rosa; McCrink, Koleen; de Hevia, Maria-Dolores; Vallortigara, Giorgio; Regolin, Lucia

2016-07-28

A large body of literature shows that non-human animals master a variety of numerical tasks, but studies involving proportional discrimination are sparse and primarily done with mature animals. Here we trained 4-day-old domestic chicks (Gallus gallus) to respond to stimuli depicting multiple examples of the proportion 4:1 when compared with the proportion 2:1. Stimuli were composed of green and red dot arrays; for the rewarded 4:1 proportion, 4 green dots for every red dot (e.g. ratios: 32:8, 12:3, and 44:11). The birds continued to discriminate when presented with new ratios at test (such as 20:5), characterized by new numbers of dots and new spatial configurations (Experiment 1). This indicates that chicks can extract the common proportional value shared by different ratios and apply it to new ones. In Experiment 2, chicks identified a specific proportion (2:1) from either a smaller (4:1) or a larger one (1:1), demonstrating an ability to represent the specific, and not relative, value of a particular proportion. Again, at test, chicks selectively responded to the previously reinforced proportion from new ratios. These findings provide strong evidence for very young animals' ability to extract, identify, and productively use proportion information across a range of different amounts.

Challenges for Data Archival Centers in Evolving Environmental Sciences

NASA Astrophysics Data System (ADS)

Wei, Y.; Cook, R. B.; Gu, L.; Santhana Vannan, S. K.; Beaty, T.

2015-12-01

Environmental science has entered into a big data era as enormous data about the Earth environment are continuously collected through field and airborne missions, remote sensing observations, model simulations, sensor networks, etc. An open-access and open-management data infrastructure for data-intensive science is a major grand challenge in global environmental research (BERAC, 2010). Such an infrastructure, as exemplified in EOSDIS, GEOSS, and NSF EarthCube, will provide a complete lifecycle of environmental data and ensures that data will smoothly flow among different phases of collection, preservation, integration, and analysis. Data archival centers, as the data integration units closest to data providers, serve as the source power to compile and integrate heterogeneous environmental data into this global infrastructure. This presentation discusses the interoperability challenges and practices of geosciences from the aspect of data archival centers, based on the operational experiences of the NASA-sponsored Oak Ridge National Laboratory Distributed Active Archive Center (ORNL DAAC) and related environmental data management activities. Specifically, we will discuss the challenges to 1) encourage and help scientists to more actively share data with the broader scientific community, so that valuable environmental data, especially those dark data collected by individual scientists in small independent projects, can be shared and integrated into the infrastructure to tackle big science questions; 2) curate heterogeneous multi-disciplinary data, focusing on the key aspects of identification, format, metadata, data quality, and semantics to make them ready to be plugged into a global data infrastructure. We will highlight data curation practices at the ORNL DAAC for global campaigns such as BOREAS, LBA, SAFARI 2000; and 3) enhance the capabilities to more effectively and efficiently expose and deliver "big" environmental data to broad range of users and systems. Experiences and challenges with integrating large data sets via the ORNL DAAC's data discovery and delivery Web services will be discussed.

ORNL`s war on crime, technically speaking

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiques, P.

This paper describes research being carried out by the Center for Applied Science and Technology for Law Enforcement (CASTLE), at Oak Ridge National Laboratory. This program works on projects which are solvable, affordable, and outside the scope of the private sector. Examples are presented of work related to: the lifetime of childrens fingerprints compared to adults; the development of ways of providing cooler body armor; digital enhancement technology applied to security-camera images from crime scenes; victim identification by skeletal reconstruction for use by forensic anthropologists.

A Critical Review of the Development of Several Viscoplastic Constitutive Theories.

DTIC Science & Technology

1987-09-15

20, 1241 -1251 (1949). [14] E. Krempl and P. Hewelt, "The Constant Volume Hypothesis for the Inelastic Deformation of Metals in the Small Strain Range...Analytical Representation of the Creep Strain-Time Behavior of Commercially Heat Treated Alloy 718," ORNL /TM-6232, 1978. 71 .r w *~ *U* ~ ~ V.WJW -9...Analytical Representation of the Creep Strain-Time Behavior of Commercially Heat Treated Alloy 718," ORNL /TM 6232, 1978. (67 M.A. Eisenberg and C.F

Production of Neutral Beams from Negative Ion Beam Systems in the USSR

DTIC Science & Technology

1982-12-01

research is to produce long-pulse and CW high-energy neutral beams. The Oak Ridge National Laboratory ( ORNL ) has been concentrating on the direct extraction...next generation of mirror devices [1II. ORNL is using a cesium converter to produce negative ions from low-energy positive ions from a duopigatron ion...with Formation of Highly Excited Hydrogen Atoms," ZhTF, Vol. 36, No. 7, 1966, p. 1241 . 107. Kartashev, K. B., V. I. Pistunovich, V. V. Platonov, V. D

Sustainable microalgae for the simultaneous synthesis of carbon quantum dots for cellular imaging and porous carbon for CO2 capture.

PubMed

Guo, Li-Ping; Zhang, Yan; Li, Wen-Cui

2017-05-01

Microalgae biomass is a sustainable source with the potential to produce a range of products. However, there is currently a lack of practical and functional processes to enable the high-efficiency utilization of the microalgae. We report here a hydrothermal process to maximize the utilizability of microalgae biomass. Specifically, our concept involves the simultaneous conversion of microalgae to (i) hydrophilic and stable carbon quantum dots and (ii) porous carbon. The synthesis is easily scalable and eco-friendly. The microalgae-derived carbon quantum dots possess a strong two-photon fluorescence property, have a low cytotoxicity and an efficient cellular uptake, and show potential for high contrast bioimaging. The microalgae-based porous carbons show excellent CO 2 capture capacities of 6.9 and 4.2mmolg -1 at 0 and 25°C respectively, primarily due to the high micropore volume (0.59cm 3 g -1 ) and large specific surface area (1396m 2 g -1 ). Copyright © 2017 Elsevier Inc. All rights reserved.

Convection-enhanced delivery of targeted quantum dot-immunoliposome hybrid nanoparticles to intracranial brain tumor models.

PubMed

Weng, Kevin C; Hashizume, Rintaro; Noble, Charles O; Serwer, Laura P; Drummond, Daryl C; Kirpotin, Dmitri B; Kuwabara, Anne M; Chao, Lucy X; Chen, Fanqing F; James, Charles D; Park, John W

2013-12-01

The aim of this work is to evaluate combining targeting strategy and convection-enhanced delivery in brain tumor models by imaging quantum dot-immunoliposome hybrid nanoparticles. An EGF receptor-targeted, quantum dot-immunoliposome hybrid nanoparticle (QD-IL) was synthesized. In vitro uptake was measured by flow cytometry and intracellular localization was imaged by confocal microscopy. In the in vivo study, QD-ILs were delivered to intracranial xenografts via convection-enhanced delivery and fluorescence was monitored noninvasively in real-time. QD-ILs exhibited specific and efficient uptake in vitro and exhibited approximately 1.3- to 5.0-fold higher total fluorescence compared with nontargeted counterpart in intracranial brain tumor xenografts in vivo. QD-ILs serve as an effective imaging agent in vitro and in vivo, and the data suggest that ligand-directed liposomal nanoparticles in conjunction with convection-enhanced delivery may offer therapeutic benefits for glioblastoma treatment as a result of specific and efficient uptake by malignant cells.

Simulation Test System of Non-Contact D-dot Voltage Transformer

NASA Astrophysics Data System (ADS)

Yang, Jie; Wang, Jingang; Luo, Ruixi; Gao, Can; Songnong, Li; Kongjun, Zhou

2016-04-01

The development trend of future voltage transformer in smart grid is non-contact measurement, miniaturization and intellectualization. This paper proposes one simulation test system of non-contact D-dot transformer for voltage measurement. This simulation test system consists of D-dot transformer, signal processing circuit and ground PC port. D-dot transformer realizes the indirect voltage measurement by measuring the change rate of electric displacement vector, a non-contact means (He et al. 2004, Principles and experiments of voltage transformer based on self-integrating D-dot probe. Proc CSEE 2014;15:2445-51). Specific to the characteristics of D-dot transformer signals, signal processing circuits with strong resistance to interference and distortion-free amplified sensor output signal are designed. WIFI wireless network is used to transmit the voltage detection to LabVIEW-based ground collection port and LabVIEW technology is adopted for signal reception, data processing and analysis and other functions. Finally, a test platform is established to simulate the performance of the whole test system of single-phase voltage transformer. Test results indicate that this voltage transformer has sound real-time performance, high accuracy and fast response speed and the simulation test system is stable and reliable and can be a new prototype of voltage transformers.

Post-Service Examination of PWR Baffle Bolts, Part I. Examination and Test Plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leonard, Keith J.; Sokolov, Mikhail A.; Gussev, Maxim N.

2015-04-30

In support of extended service and current operations of the US nuclear reactor plants, the Oak Ridge National Laboratory (ORNL), through the Department of Energy (DOE), Light Water Reactor Sustainability (LWRS) Program, is coordinating with Ginna Nuclear Power Plant, The Westinghouse Electric Company, LLC, and ATI Consulting, the selective procurement of baffle bolts that were withdrawn from service in 2011 and currently stored on site at Ginna. The goal of this program is to perform detailed microstructural and mechanical property characterization of baffle former bolts following in-service exposures. This report outlines the selection criteria of the bolts and the techniquesmore » to be used in this study. The bolts available are the original alloy 347 steel fasteners used in holding the baffle plates to the baffle former structures within the lower portion of the pressurized water reactor vessel. Of the eleven possible bolts made available for this work, none were identified to have specific damage. The bolts, however, did show varying levels of breakaway torque required in their removal. The bolts available for this study varied in peak fluence (highest dose within the head of the bolt) between 9.9 and 27.8x10 21 n/cm 2 (E>1MeV). As no evidence for crack initiation was determined for the available bolts from preliminary visual examination, two bolts with the higher fluence values were selected for further post-irradiation examination. The two bolts showed different breakaway torque levels necessary in their removal. The information from these bolts will be integral to the LWRS program initiatives in evaluating end of life microstructure and properties. Furthermore, valuable data will be obtained that can be incorporated into model predictions of long-term irradiation behavior and compared to results obtained in high flux experimental reactor conditions. The two bolts selected for the ORNL study will be shipped to Westinghouse with bolts of interest to their collaborative efforts with the Electric Power Research Institute. Westinghouse will section the ORNL bolts into samples specified in this report and return them to ORNL. Samples will include bend bars for fracture toughness and crack propagation studies along with thin sections from which specimens for bend testing, subscale tensile and microstructural analysis can be obtained. Additional material from the high stress concentration region at the transition between the bolt head and shank will also be preserved to allow for further investigation of possible crack initiation sites.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Retterer, S. T.; Holsapple, M. P.

A Cooperative Research and Development Agreement (CRADA) was established between Battelle Memorial Institute (BMI), Pacific Northwest National Laboratory (PNNL), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Lawrence Livermore National Laboratory (LLNL) with the goal of combining the analytical and synthetic strengths of the National Laboratories with BMI's expertise in basic and translational medical research to develop a collaborative pipeline and suite of high throughput and imaging technologies that could be used to provide a more comprehensive understanding of material and drug toxicology in humans. The Multi-Scale Toxicity Initiative (MSTI), consisting of the team members above, was established tomore » coordinate cellular scale, high-throughput in vitro testing, computational modeling and whole animal in vivo toxicology studies between MSTI team members. Development of a common, well-characterized set of materials for testing was identified as a crucial need for the initiative. Two research tracks were established by BMI during the course of the CRADA. The first research track focused on the development of tools and techniques for understanding the toxicity of nanomaterials, specifically inorganic nanoparticles (NPs). ORNL"s work focused primarily on the synthesis, functionalization and characterization of a common set of NPs for dissemination to the participating laboratories. These particles were synthesized to retain the same surface characteristics and size, but to allow visualization using the variety of imaging technologies present across the team. Characterization included the quantitative analysis of physical and chemical properties of the materials as well as the preliminary assessment of NP toxicity using commercially available toxicity screens and emerging optical imaging strategies. Additional efforts examined the development of high-throughput microfluidic and imaging assays for measuring NP uptake, localization, and toxicity in vitro. The second research track within the MSTI CRADA focused on the development of ex vivo animal models for examining druginduced cardiotoxicity. ORNL's role in the second track was limited initially, but was later expanded to include the development of microfluidic platforms that might facilitate the translation of Cardiac 'Microwire' technologies developed at the University of Toronto into a functional platform for drug screening and predictive assessment of cardiotoxicity via highthroughput measurements of contractility. This work was coordinated by BMI with the Centre for the Commercialization of Regenerative Medicine (CCRM) and the University of Toronto (U Toronto). This partnership was expanded and culminated in the submission of proposal to Work for Others (WFO) agencies to explore the development of a broader set of microphysiological systems, a so call human-on-a-chip, that could be used for toxicity screening and the evaluation of bio-threat countermeasures.« less

49 CFR 179.100-1 - Tanks built under these specifications shall comply with the requirements of §§ 179.100, 179.101...

Code of Federal Regulations, 2013 CFR

2013-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.100-1 - Tanks built under these specifications shall comply with the requirements of §§ 179.100, 179.101...

Code of Federal Regulations, 2014 CFR

2014-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.100-1 - Tanks built under these specifications shall comply with the requirements of §§ 179.100, 179.101...

Code of Federal Regulations, 2010 CFR

2010-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.100-1 - Tanks built under these specifications shall comply with the requirements of §§ 179.100, 179.101...

Code of Federal Regulations, 2011 CFR

2011-10-01

...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.101 - Individual specification requirements applicable to pressure tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... to pressure tank car tanks. 179.101 Section 179.101 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.101 Individual specification requirements applicable to pressure tank car...

49 CFR 179.101 - Individual specification requirements applicable to pressure tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to pressure tank car tanks. 179.101 Section 179.101 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.101 Individual specification requirements applicable to pressure tank car...

49 CFR 179.101 - Individual specification requirements applicable to pressure tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to pressure tank car tanks. 179.101 Section 179.101 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.101 Individual specification requirements applicable to pressure tank car...

49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., intermediate bulk containers, multi-unit tank car tanks, portable tanks, or tank cars. Cargo tank motor vehicle... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... MATERIALS REGULATIONS SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle...

49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., intermediate bulk containers, multi-unit tank car tanks, portable tanks, or tank cars. Cargo tank motor vehicle... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation...

49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., intermediate bulk containers, multi-unit tank car tanks, portable tanks, or tank cars. Cargo tank motor vehicle... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation...

49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., intermediate bulk containers, multi-unit tank car tanks, portable tanks, or tank cars. Cargo tank motor vehicle... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation...

49 CFR 178.320 - General requirements applicable to all DOT specification cargo tank motor vehicles.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., intermediate bulk containers, multi-unit tank car tanks, portable tanks, or tank cars. Cargo tank motor vehicle... specification cargo tank motor vehicles. 178.320 Section 178.320 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR PACKAGINGS Specifications for Containers for Motor Vehicle Transportation...

Shape-specific perceptual learning in a figure-ground segregation task.

PubMed

Yi, Do-Joon; Olson, Ingrid R; Chun, Marvin M

2006-03-01

What does perceptual experience contribute to figure-ground segregation? To study this question, we trained observers to search for symmetric dot patterns embedded in random dot backgrounds. Training improved shape segmentation, but learning did not completely transfer either to untrained locations or to untrained shapes. Such partial specificity persisted for a month after training. Interestingly, training on shapes in empty backgrounds did not help segmentation of the trained shapes in noisy backgrounds. Our results suggest that perceptual training increases the involvement of early sensory neurons in the segmentation of trained shapes, and that successful segmentation requires perceptual skills beyond shape recognition alone.

HLA typing in patients with multiple evanescent white dot syndrome (MEWDS).

PubMed

Borruat, F X; Herbort, C P; Spertini, F; Desarnaulds, A B

1998-03-01

Multiple evanescent white dot syndrome (MEWDS) is an acquired chorioretinal disorder of unknown etiology. We investigated the possibility that MEWDS might be related to a specific HLA subtyping. Blood was obtained from nine patients affected by MEWDS. HLA-B51 was found in four of these nine patients with MEWDS. There was a 3.7-fold increased frequency of HLA-B51 in patients affected by MEWDS (relative risk 5.86). MEWDS might then be related to the presence of a specific HLA subtype, HLA-B51. However, due to the small sample size, our results need to be confirmed by further testing.

Multimodality Imaging with Silica-Based Targeted Nanoparticle Platforms

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jason S. Lewis

2012-04-09

Objectives: To synthesize and characterize a C-Dot silica-based nanoparticle containing 'clickable' groups for the subsequent attachment of targeting moieties (e.g., peptides) and multiple contrast agents (e.g., radionuclides with high specific activity) [1,2]. These new constructs will be tested in suitable tumor models in vitro and in vivo to ensure maintenance of target-specificity and high specific activity. Methods: Cy5 dye molecules are cross-linked to a silica precursor which is reacted to form a dye-rich core particle. This core is then encapsulated in a layer of pure silica to create the core-shell C-Dot (Figure 1) [2]. A 'click' chemistry approach has beenmore » used to functionalize the silica shell with radionuclides conferring high contrast and specific activity (e.g. 64Cu and 89Zr) and peptides for tumor targeting (e.g. cRGD and octreotate) [3]. Based on the selective Diels-Alder reaction between tetrazine and norbornene, the reaction is bioorthogonal, highyielding, rapid, and water-compatible. This radiolabeling approach has already been employed successfully with both short peptides (e.g. octreotate) and antibodies (e.g. trastuzumab) as model systems for the ultimate labeling of the nanoparticles [1]. Results: PEGylated C-Dots with a Cy5 core and labeled with tetrazine have been synthesized (d = 55 nm, zeta potential = -3 mV) reliably and reproducibly and have been shown to be stable under physiological conditions for up to 1 month. Characterization of the nanoparticles revealed that the immobilized Cy5 dye within the C-Dots exhibited fluorescence intensities over twice that of the fluorophore alone. The nanoparticles were successfully radiolabeled with Cu-64. Efforts toward the conjugation of targeting peptides (e.g. cRGD) are underway. In vitro stability, specificity, and uptake studies as well as in vivo imaging and biodistribution investigations will be presented. Conclusions: C-Dot silica-based nanoparticles offer a robust, versatile, and multi-functional platform to enhance in vivo detection sensitivity and non-invasively assay receptor expression/status of tumor cellular targets, including those of low abundance, using nuclear-NIR fluorescence imaging approaches [2]. Improvements in molecular diagnostics, refined by the availability of nanotechnology platforms, will be a key determinant in driving early-stage disease detection and prevention, ultimately leading to decreases in mortality.« less

PCR colorimetric dot-blot assay and clinical pretest probability for diagnosis of Pulmonary Tuberculosis in Smear-Negative patients

PubMed Central

Scherer, Luciene Cardoso; Sperhacke, Rosa Dea; Jarczewski, Carla; Cafrune, Patrícia I; Minghelli, Simone; Ribeiro, Marta Osório; Mello, Fernanda CQ; Ruffino-Netto, Antonio; Rossetti, Maria LR; Kritski, Afrânio L

2007-01-01

Background Smear-negative pulmonary tuberculosis (SNPTB) accounts for 30% of Pulmonary Tuberculosis (PTB) cases reported annually in developing nations. Polymerase chain reaction (PCR) may provide an alternative for the rapid detection of Mycobacterium tuberculosis (MTB); however little data are available regarding the clinical utility of PCR in SNPTB, in a setting with a high burden of TB/HIV co-infection. Methods To evaluate the performance of the PCR dot-blot in parallel with pretest probability (Clinical Suspicion) in patients suspected of having SNPTB, a prospective study of 213 individuals with clinical and radiological suspicion of SNPTB was carried out from May 2003 to May 2004, in a TB/HIV reference hospital. Respiratory specialists estimated the pretest probability of active disease into high, intermediate, low categories. Expectorated sputum was examined by direct microscopy (Ziehl-Neelsen staining), culture (Lowenstein Jensen) and PCR dot-blot. Gold standard was based on culture positivity combined with the clinical definition of PTB. Results In smear-negative and HIV subjects, active PTB was diagnosed in 28.4% (43/151) and 42.2% (19/45), respectively. In the high, intermediate and low pretest probability categories active PTB was diagnosed in 67.4% (31/46), 24% (6/25), 7.5% (6/80), respectively. PCR had sensitivity of 65% (CI 95%: 50%–78%) and specificity of 83% (CI 95%: 75%–89%). There was no difference in the sensitivity of PCR in relation to HIV status. PCR sensitivity and specificity among non-previously TB treated and those treated in the past were, respectively: 69%, 43%, 85% and 80%. The high pretest probability, when used as a diagnostic test, had sensitivity of 72% (CI 95%:57%–84%) and specificity of 86% (CI 95%:78%–92%). Using the PCR dot-blot in parallel with high pretest probability as a diagnostic test, sensitivity, specificity, positive and negative predictive values were: 90%, 71%, 75%, and 88%, respectively. Among non-previously TB treated and HIV subjects, this approach had sensitivity, specificity, positive and negative predictive values of 91%, 79%, 81%, 90%, and 90%, 65%, 72%, 88%, respectively. Conclusion PCR dot-blot associated with a high clinical suspicion may provide an important contribution to the diagnosis of SNPTB mainly in patients that have not been previously treated attended at a TB/HIV reference hospital. PMID:18096069

Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles.

PubMed

Madhankumar, A B; Mrowczynski, Oliver D; Patel, Suhag R; Weston, Cody L; Zacharia, Brad E; Glantz, Michael J; Siedlecki, Christopher A; Xu, Li-Chong; Connor, James R

2017-08-01

Cadmium selenide (CdSe) based quantum dots modified with polyethylene glycol and chemically linked to interleukin-13 (IL13) were prepared with the aim of identifying the high affinity receptor (IL13Rα2) which is expressed in glioma stem cells and exosomes secreted by these cancer stem cells. IL13 conjugated quantum dots (IL13QD) were thoroughly characterized for their physicochemical properties including particle size and surface morphology. Furthermore, the specific binding of the IL13QD to glioma cells and to glioma stem cells (GSC) was verified using a competitive binding study. The exosomes were isolated from the GSC conditioned medium and the expression of IL13Rα2 in the GSC and exosomes was verified. The binding property of IL13QD to the tumor associated exosomes was initially confirmed by transmission electron microscopy. The force of attraction between the quantum dots and U251 glioma cells and the exosomes was investigated by atomic force microscopy, which indicated a higher force of binding interaction between the IL13QD and IL13Rα2 expressing glioma cells and exosomes secreted by glioma stem cells. Flow cytometry of the IL13QD and exosomes from the culture media and cerebrospinal fluid (CSF) of patients with glioma tumors indicated a distinctly populated complex pattern different from that of non-targeted quantum dots and bovine serum albumin (BSA) conjugated quantum dots confirming specific binding potential of the IL13QD to the tumor associated exosomes. The results of this study demonstrate that IL13QD can serve as an ex vivo marker for glioma stem cells and exosomes that can inform diagnosis and prognosis of patients harboring malignant disease. Functionalized quantum dots are flexible semiconductor nanomaterials which have an immense application in biomedical research. In particular, when they are functionalized with biomolecules like proteins or antibodies, they have the specialized ability to detect the expression of receptors and antigens in cells and tissues. In this study we designed a cytokine (interleukin-13) functionalized quantum dot to detect a cancer associated receptor expressed in cancer stem cells and the extracellular vesicles (exosomes) secreted by the cancer cells themselves. The binding pattern of these cytokine modified quantum dots to the cancer stem cells and exosomes alters the physical properties of the complex in the fixed and suspended form. This altered binding pattern can be monitored by a variety of techniques, including transmission electron microscopy, atomic force microscopy and flow cytometry, and subsequent characterization of this quantum dot binding profile provides useful data that can be utilized as a fingerprint to detect cancer disease progression. This type of functionalized quantum dot fingerprint is especially useful for invasive cancers including brain and other metastatic cancers and may allow for earlier detection of disease progression or recurrence, thus saving the lives of patients suffering from this devastating disease. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Magnetic bead-quantum dot assay for detection of a biomarker for traumatic brain injury

NASA Astrophysics Data System (ADS)

Kim, Chloe; Searson, Peter C.

2015-10-01

Current diagnostic methods for traumatic brain injury (TBI), which accounts for 15% of all emergency room visits, are limited to neuroimaging modalities. The challenges of accurate diagnosis and monitoring of TBI have created the need for a simple and sensitive blood test to detect brain-specific biomarkers. Here we report on an assay for detection of S100B, a putative biomarker for TBI, using antibody-conjugated magnetic beads for capture of the protein, and antibody-conjugated quantum dots for optical detection. From Western Blot, we show efficient antigen capture and concentration by the magnetic beads. Using magnetic bead capture and quantum dot detection in serum samples, we show a wide detection range and detection limit below the clinical cut-off level.Current diagnostic methods for traumatic brain injury (TBI), which accounts for 15% of all emergency room visits, are limited to neuroimaging modalities. The challenges of accurate diagnosis and monitoring of TBI have created the need for a simple and sensitive blood test to detect brain-specific biomarkers. Here we report on an assay for detection of S100B, a putative biomarker for TBI, using antibody-conjugated magnetic beads for capture of the protein, and antibody-conjugated quantum dots for optical detection. From Western Blot, we show efficient antigen capture and concentration by the magnetic beads. Using magnetic bead capture and quantum dot detection in serum samples, we show a wide detection range and detection limit below the clinical cut-off level. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr05608j

In vitro detection of canine distemper virus nucleic acid with a virus-specific cDNA probe by dot-blot and in situ hybridization.

PubMed

Oglesbee, M; Jackwood, D; Perrine, K; Axthelm, M; Krakowka, S; Rice, J

1986-11-01

A cDNA library was prepared from canine distemper viral (CDV) messenger RNA (mRNA) derived from Vero cells lytically infected with the Onderstepoort strain (Ond) of CDV. A 300 base pair insert was identified which, by Northern blot analysis and Sanger sequence data, was shown to be specific to the nucleocapsid gene. The nucleocapsid (NC) clone was radiolabelled with 32P using nick translation and used to detect viral RNA in both dot-blot and in situ preparations of Vero cells lytically infected with Onderstepoort CDV (Ond-CDV) and immortalized mink lung cells persistently infected with racoon origin CDV (CCL64-RCDV). Dot-blot hybridization results paralleled immunofluorescent results in the lytically infected cells. In 18 persistently infected cell lines from the RCDV-CCL64 parental stock, 13 lines were positive and two were negative on both immunofluorescence and dot-blot hybridization analysis for CDV antigen and RNA, respectively. Viral nucleic acid was detected in these persistently infected cells, where as few as 1.9% of the members of a line were positive on immunofluorescence. A dot-blot autoradiographic signal was obtained in three lines which were negative for CDV antigen. CDV RNA was detected in both lytically and persistently infected cell lines by in situ hybridization, where decreasing probe length was important in increasing the sensitivity of this assay. Viral RNA was detected in over 90% of the lytically infected cells, where only 70% were positive for viral antigen by immunofluorescence.

(Boiling water reactor (BWR) CORA experiments)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ott, L.J.

To participate in the 1990 CORA Workshop at Kernforschungszentrum Karlsruhe (KfK) GmbH, Karlsruhe, FRG, on October 1--4, and to participate in detailed discussions on October 5 with the KfK CORA Boiling Water Reactor (BWR) experiments. The traveler attended the 1990 CORA Workshop at KfK, FRG. Participation included the presentation of a paper on work performed by the Boiling Water Reactor Core Melt Progression Phenomena Program at Oak Ridge National Laboratory (ORNL) on posttest analyses of CORA BWR experiments. The Statement of Work (November 1989) for the BWR Core Melt Progression Phenomena Program provides for pretest and posttest analyses of themore » BWR CORA experiments performed at KfK. Additionally, it is intended that ORNL personnel participate in the planning process for future CORA BWR experiments. For these purposes, meetings were held with KfK staff to discuss such topics as (1) experimental test schedule, (2) BWR test conduct, (3) perceived BWR experimental needs, and (4) KfK operational staff needs with respect to ORNL support. 19 refs.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trivelpiece, A.W.

In January 1996, when the management and operation (M and O) contract for the Oak Ridge National Laboratory (ORNL) was awarded to Lockheed Martin Energy Research Corporation, they were presented with the opportunity to develop and implement a management structure tailored to the Laboratory's needs and functions. In response, they launched a Laboratory-wide reengineering effort and undertook other work with the goal of fostering excellence, relevance, and stewardship in all aspects of the Laboratory's operations. This effort is paying off in improvements in their ability to meet the expectations established for ORNL as a Department of Energy laboratory overseen bymore » the Office of Science: delivering advances in science and technology, securing new capabilities, improving the ability to operate safely and efficiently at reasonable cost, and being a good neighbor. The development of critical outcomes and objectives, now under way in partnership with the Department's Oak Ridge Operations Office, is aimed at providing a performance-based means of determining how ORNL measures up to these expectations.« less

Validation of tungsten cross sections in the neutron energy region up to 100 keV

NASA Astrophysics Data System (ADS)

Pigni, Marco T.; Žerovnik, Gašper; Leal, Luiz. C.; Trkov, Andrej

2017-09-01

Following a series of recent cross section evaluations on tungsten isotopes performed at Oak Ridge National Laboratory (ORNL), this paper presents the validation work carried out to test the performance of the evaluated cross sections based on lead-slowing-down (LSD) benchmarks conducted in Grenoble. ORNL completed the resonance parameter evaluation of four tungsten isotopes - 182,183,184,186W - in August 2014 and submitted it as an ENDF-compatible file to be part of the next release of the ENDF/B-VIII.0 nuclear data library. The evaluations were performed with support from the US Nuclear Criticality Safety Program in an effort to provide improved tungsten cross section and covariance data for criticality safety sensitivity analyses. The validation analysis based on the LSD benchmarks showed an improved agreement with the experimental response when the ORNL tungsten evaluations were included in the ENDF/B-VII.1 library. Comparison with the results obtained with the JEFF-3.2 nuclear data library are also discussed.

ORNL Remedial Action Program strategy (FY 1987-FY 1992)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trabalka, J.R.; Myrick, T.E.

1987-12-01

Over 40 years of Oak Ridge National Laboratory (ORNL) operations have produced a diverse legacy of contaminated inactive facilities, research areas, and waste disposal areas that are potential candidates for remedial action. The ORNL Remedial Action Program (RAP) represents a comprehensive effort to meet new regulatory requirements and ensure adequate protection of on-site workers, the public, and the environment by providing appropriate corrective measures at over 130 sites contaminated historically with radioactive, hazardous chemical, or mixed wastes. A structured path of program planning, site characterization, alternatives assessment, technology development, engineering design, continued site maintenance and surveillance, interim corrective action, andmore » eventual site closure or decommissioning is required to meet these objectives. This report documents the development of the Remedial Action Program, through its preliminary characterization, regulatory interface, and strategy development activities. It provides recommendations for a comprehensive, long-term strategy consistent with existing technical, institutional, and regulatory information, along with a six-year plan for achieving its initial objectives. 53 refs., 8 figs., 12 tabs.« less

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

49 CFR 179.202-179.202-22 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) §§ 179.202—179.202-22 [Reserved] ...

49 CFR 179.200-23 - Tests of pressure relief valves.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-23 Tests of...

Training on automated machine guidance.

DOT National Transportation Integrated Search

2009-05-01

"Beginning in 2006, WisDOT and the Construction Materials Support Center (CMSC) at UW-Madison worked together : to develop the specifications and the QA/QC procedures for GPS machine guidance on highway grading projects. These : specifications and pr...

Semiconductor Quantum Dots with Photoresponsive Ligands.

PubMed

Sansalone, Lorenzo; Tang, Sicheng; Zhang, Yang; Thapaliya, Ek Raj; Raymo, Françisco M; Garcia-Amorós, Jaume

2016-10-01

Photochromic or photocaged ligands can be anchored to the outer shell of semiconductor quantum dots in order to control the photophysical properties of these inorganic nanocrystals with optical stimulations. One of the two interconvertible states of the photoresponsive ligands can be designed to accept either an electron or energy from the excited quantum dots and quench their luminescence. Under these conditions, the reversible transformations of photochromic ligands or the irreversible cleavage of photocaged counterparts translates into the possibility to switch luminescence with external control. As an alternative to regulating the photophysics of a quantum dot via the photochemistry of its ligands, the photochemistry of the latter can be controlled by relying on the photophysics of the former. The transfer of excitation energy from a quantum dot to a photocaged ligand populates the excited state of the species adsorbed on the nanocrystal to induce a photochemical reaction. This mechanism, in conjunction with the large two-photon absorption cross section of quantum dots, can be exploited to release nitric oxide or to generate singlet oxygen under near-infrared irradiation. Thus, the combination of semiconductor quantum dots and photoresponsive ligands offers the opportunity to assemble nanostructured constructs with specific functions on the basis of electron or energy transfer processes. The photoswitchable luminescence and ability to photoinduce the release of reactive chemicals, associated with the resulting systems, can be particularly valuable in biomedical research and can, ultimately, lead to the realization of imaging probes for diagnostic applications as well as to therapeutic agents for the treatment of cancer.

Enhanced Fluorescence Properties of Carbon Dots in Polymer Films

PubMed Central

Liu, Yamin; Wang, Ping; Shiral Fernando, K. A.; LeCroy, Gregory E.; Maimaiti, Halidan; Harruff-Miller, Barbara A.; Lewis, William K.; Bunker, Christopher E.; Hou, Zhi-Ling; Sun, Ya-Ping

2016-01-01

Carbon dots of small carbon nanoparticles surface-functionalized with 2,2′-(ethylenedioxy)bis(ethylamine) (EDA) were synthesized, and the as-synthesized sample was separated on an aqueous gel column to obtain fractions of the EDA-carbon dots with different fluorescence quantum yields. As already discussed in the literature, the variations in fluorescence performance among the fractions were attributed to the different levels and/or effectiveness of the surface functionalization-passivation in the carbon dots. These fractions, as well as carbon nanoparticles without any deliberate surface functionalization, were dispersed into poly(vinyl alcohol) (PVA) for composite films. In the PVA film matrix, the carbon dots and nanoparticles exhibited much enhanced fluorescence emissions in comparison with their corresponding aqueous solutions. The increased fluorescence quantum yields in the films were determined quantitatively by using a specifically designed and constructed film sample holder in the emission spectrometer. The observed fluorescence decays of the EDA-carbon dots in film and in solution were essentially the same, suggesting that the significant enhancement in fluorescence quantum yields from solution to film is static in nature. Mechanistic implications of the results, including a rationalization in terms of the compression effect on the surface passivation layer (similar to a soft corona) in carbon dots when embedded in the more restrictive film environment resulting in more favorable radiative recombinations of the carbon particle surface-trapped electrons and holes, and also potential technological applications of the brightly fluorescent composite films are highlighted and discussed. PMID:28133537

Simulink/PARS Integration Support

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vacaliuc, B.; Nakhaee, N.

2013-12-18

The state of the art for signal processor hardware has far out-paced the development tools for placing applications on that hardware. In addition, signal processors are available in a variety of architectures, each uniquely capable of handling specific types of signal processing efficiently. With these processors becoming smaller and demanding less power, it has become possible to group multiple processors, a heterogeneous set of processors, into single systems. Different portions of the desired problem set can be assigned to different processor types as appropriate. As software development tools do not keep pace with these processors, especially when multiple processors ofmore » different types are used, a method is needed to enable software code portability among multiple processors and multiple types of processors along with their respective software environments. Sundance DSP, Inc. has developed a software toolkit called “PARS”, whose objective is to provide a framework that uses suites of tools provided by different vendors, along with modeling tools and a real time operating system, to build an application that spans different processor types. The software language used to express the behavior of the system is a very high level modeling language, “Simulink”, a MathWorks product. ORNL has used this toolkit to effectively implement several deliverables. This CRADA describes this collaboration between ORNL and Sundance DSP, Inc.« less

Determination of Desorbed Species During Heating of AgI-Mordenite Provided by ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croes, Kenneth James; Garino, Terry J.; Mowry, Curtis D.

This study is focused on describing the desorbed off gases due to heating of the AgIMordenite (MOR) produced at ORNL for iodine (I 2) gas capture from nuclear fuel aqueous reprocessing. In particular, the interest is for the incorporation of the AgI-MOR into a waste form, which might be the Sandia developed, low temperature sintering, Bi-Si oxide based, Glass Composite Material (GCM). The GCM has been developed as a waste form for the incorporation any oxide based getter material. In the case where iodine may be released during the sintering process of the GCM, additional Ag flake is added asmore » further insurance in total iodine capture and retention. This has been the case for the incorporated ORNL developed AgIMOR. Thermal analysis studies were carried out to determine off gasing processes of ORNL AgIMOR. Independent of sample size, ~7wt% of total water is desorbed by 225°C. This includes both bulk surface and occluded water, and are monitored as H2O and OH. Of that total, ~5.5wt% is surface water which is removed by 125°C, and 1.5wt% is occluded (in zeolite pore) water. Less than ~1 wt% total water continues to desorb, but is completely removed by 500°C. Above 300°C, the detectable remaining desorbing species observed are iodine containing compounds, including I and I 2.« less

Hybrid Heat Pumps Using Selective Water Sorbents (SWS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ally, M. R.

2006-11-30

The development of the ground-coupled and air-coupled Heating Ventilation and Air-Conditioning (HVAC) system is essential in meeting the goals of Zero Energy Houses (ZEH), a viable concept vigorously pursued under DOE sponsorship. ORNL has a large Habitat for Humanity complex in Lenoir City where modem buildings technology is incorporated on a continual basis. This house of the future is planned for lower and middle income families in the 21st century. The work undertaken in this CRADA is an integral part of meeting DOE's objectives in the Building America program. SWS technology is a prime candidate for reducing the footprint, costmore » and improve the performance of ground-coupled heat pumps. The efficacy of this technique to exchange energy with the ground is a topic of immense interest to DOE, builders and HVAC equipment manufacturers. If successful, the SWS concept will become part of a packaged ZEH kit for affordable and high-end houses. Lennox Industries entered into a CRADA with Oak Ridge National Laboratory in November 2004. Lennox, Inc. agreed to explore ways of using Selective Water Sorbent materials to boost the efficiency of air-coupled heat pumps whereas ORNL concentrated on ground-coupled applications. Lennox supplied ORNL with heat exchangers and heat pump equipment for use at ORNL's Habitat for Humanity site in Lenoir City, Tennessee. Lennox is focused upon air-coupled applications of SWS materials at the Product Development and Research Center in Carrollton, TX.« less

ABC transporters affect the elimination and toxicity of CdTe quantum dots in liver and kidney cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Mingli; Yin, Huancai; Bai, Pengli

This paper aimed to investigate the role of adenosine triphosphate-binding cassette (ABC) transporters on the efflux and the toxicity of nanoparticles in liver and kidney cells. In this study, we synthesized CdTe quantum dots (QDs) that were monodispersed and emitted green fluorescence (maximum peak at 530 nm). Such QDs tended to accumulate in human hepatocellular carcinoma cells (HepG2), human kidney cells 2 (HK-2), and Madin-Darby canine kidney (MDCK) cells, and cause significant toxicity in all the three cell lines. Using specific inhibitors and inducers of P-glycoprotein (Pgp) and multidrug resistance associated proteins (Mrps), the cellular accumulation and subsequent toxicity ofmore » QDs in HepG2 and HK-2 cells were significantly affected, while only slight changes appeared in MDCK cells, corresponding well with the functional expressions of ABC transporters in cells. Moreover, treatment of QDs caused concentration- and time- dependent induction of ABC transporters in HepG2 and HK-2 cells, but such phenomenon was barely found in MDCK cells. Furthermore, the effects of CdTe QDs on ABC transporters were found to be greater than those of CdCl{sub 2} at equivalent concentrations of cadmium, indicating that the effects of QDs should be a combination of free Cd{sup 2+} and specific properties of QDs. Overall, these results indicated a strong dependence between the functional expressions of ABC transporters and the efflux of QDs, which could be an important reason for the modulation of QDs toxicity by ABC transporters. - Highlights: • ABC transporters contributed actively to the cellular efflux of CdTe quantum dots. • ABC transporters affected the cellular toxicity of CdTe quantum dots. • Treatment of CdTe quantum dots induced the gene expression of ABC transporters. • Free Cd{sup 2+} should be partially involved in the effects of QDs on ABC transporters. • Cellular efflux of quantum dots could be an important modulator for its toxicity.« less

Efficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy.

PubMed

Delanaye, Pierre; Cavalier, Etienne; Fafin, Coraline; Dubois, Bernard E; Krzesinski, Jean-Marie; Moranne, Olivier

2016-02-01

Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m(2) and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14-36), 23 (17-31), 31 (22-38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28-44), 35 (29-41), 39 (32-47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/mL. In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D.

X-ray Crystal Structures of the Type IVb Secretion System DotB ATPases.

PubMed

Prevost, Marie S; Waksman, Gabriel

2018-05-17

Human infections by the intracellular bacterial pathogen Legionella pneumophila result in a severe form of pneumonia, the Legionnaire's disease. L. pneumophila utilises a type IVb secretion (T4bS) system termed "dot/icm" to secrete protein effectors to the host cytoplasm. The dot/icm system is powered at least in part by a functionally critical AAA+ ATPase, a protein called DotB, thought to belong to the VirB11 family of proteins. Here we present the crystal structure of DotB at 3.19 Å resolution, in its hexameric form. We observe that DotB is in fact a structural intermediate between VirB11 and PilT family proteins, with a PAS-like N-terminal domain coupled to a RecA-like C-terminal domain. It also shares critical structural elements only found in PilT. The structure also reveals two conformers, termed α and β, with an αβαβαβ configuration. The existence of α and β conformers in this class of proteins was confirmed by solving the structure of DotB from another bacterial pathogen, Yersinia, where, intriguingly, we observed an ααβααβ configuration. The two conformers co-exist regardless of the nucleotide-bound states of the proteins. Our investigation therefore reveals that these ATPases can adopt a wider range of conformational states than was known before, shedding new light on the extraordinary spectrum of conformations these ATPases can access to carry out their function. Overall, the structure of DotB provides a template for further rational drug-design to develop more specific antibiotics to tackle Legionnaire's disease. This article is protected by copyright. All rights reserved. © 2018 The Protein Society.

Modification and Validation of an Automotive Data Processing Unit, Compessed Video System, and Communications Equipment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carter, R.J.

1997-04-01

The primary purpose of the "modification and validation of an automotive data processing unit (DPU), compressed video system, and communications equipment" cooperative research and development agreement (CRADA) was to modify and validate both hardware and software, developed by Scientific Atlanta, Incorporated (S-A) for defense applications (e.g., rotary-wing airplanes), for the commercial sector surface transportation domain (i.e., automobiles and trucks). S-A also furnished a state-of-the-art compressed video digital storage and retrieval system (CVDSRS), and off-the-shelf data storage and transmission equipment to support the data acquisition system for crash avoidance research (DASCAR) project conducted by Oak Ridge National Laboratory (ORNL). In turn,more » S-A received access to hardware and technology related to DASCAR. DASCAR was subsequently removed completely and installation was repeated a number of times to gain an accurate idea of complete installation, operation, and removal of DASCAR. Upon satisfactory completion of the DASCAR construction and preliminary shakedown, ORNL provided NHTSA with an operational demonstration of DASCAR at their East Liberty, OH test facility. The demonstration included an on-the-road demonstration of the entire data acquisition system using NHTSA'S test track. In addition, the demonstration also consisted of a briefing, containing the following: ORNL generated a plan for validating the prototype data acquisition system with regard to: removal of DASCAR from an existing vehicle, and installation and calibration in other vehicles; reliability of the sensors and systems; data collection and transmission process (data integrity); impact on the drivability of the vehicle and obtrusiveness of the system to the driver; data analysis procedures; conspicuousness of the vehicle to other drivers; and DASCAR installation and removal training and documentation. In order to identify any operational problems not captured by the systems testing and evaluation, the validation plan also addressed a short-term pilot research program to manipulate DASCAR under operational conditions using "naive" drivers. The effort exercised the fill capabilities of the data acquisition system. ORNL subsequently evaluated and pilot tested the data acquisition system using the validation plan. The plan was implemented in full at the NHTSA East Liberty, OH test facility, and was carried out as a cooperative effort with the Vehicle Research and Test Center staff. ORNL determined the reliability of the sensors and systems by exercising DASCAR For one vehicle type, ORNL evaluated systems reliability over a continuous period of 30 days with particular attention paid to maintenance of calibration and data integrity.« less

Hubble's View of Little Blue Dots

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2018-02-01

The recent discovery of a new type of tiny, star-forming galaxy is the latest in a zoo of detections shedding light on our early universe. What can we learn from the unique little blue dots found in archival Hubble data?Peas, Berries, and DotsGreen pea galaxies identified by citizen scientists with Galaxy Zoo. [Richard Nowell Carolin Cardamone]As telescope capabilities improve and we develop increasingly deeper large-scale surveys of our universe, we continue to learn more about small, faraway galaxies. In recent years, increasing sensitivity first enabled the detection of green peas luminous, compact, low-mass (10 billion solar masses; compare this to the Milky Ways 1 trillion solar masses!) galaxies with high rates of star formation.Not long thereafter, we discovered galaxies that form stars similarly rapidly, but are even smaller only 330 million solar masses, spanning less than 3,000 light-years in size. These tiny powerhouses were termed blueberries for their distinctive color.Now, scientists Debra and Bruce Elmegreen (of Vassar College and IBM Research Division, respectively) report the discovery of galaxies that have even higher star formation rates and even lower masses: little blue dots.Exploring Tiny Star FactoriesThe Elmegreens discovered these unique galaxies by exploring archival Hubble data. The Hubble Frontier Fields data consist of deep images of six distant galaxy clusters and the parallel fields next to them. It was in the archival data for two Frontier Field Parallels, those for clusters Abell 2744 and MAS J0416.1-2403, that the authors noticed several galaxies that stand out as tiny, bright, blue objects that are nearly point sources.Top: a few examples of the little blue dots recently identified in two Hubble Frontier Field Parallels. Bottom: stacked images for three different groups of little blue dots. [Elmegreen Elmegreen 2017]The authors performed a search through the two Frontier Field Parallels, discovering a total of 55 little blue dots with masses spanning 105.8107.4solar masses, specific star formation rates of 10-7.4, and redshifts of 0.5 z 5.4.Exploring these little blue dots, the Elmegreens find that the galaxies sizes tend to be just a few hundred light-years across. They are gas-dominated; gas currently outweighs stars in these galaxies by perhaps a factor of five. Impressively, based on the incredibly high specific star formation rates observed in these little blue dots, they appear to have formed all of their stars in the last 1% of the age of the universe for them.An Origin for Globulars?Log-log plot of star formation rate vs. mass for the three main groups of little blue dots (red, green, and blue markers), a fourth group of candidates with different properties (brown markers), and previously discovered local blueberry galaxies. The three main groups of little blue dots appear to be low-mass analogs of blueberries. [Elmegreen Elmegreen 2017]Intriguingly, this rapid star formation might be the key to answering a long-standing question: where do globular clusters come from? The Elmegreens propose that little blue dots might actually be an explanation for the origin of these orbiting, spherical, low-metallicity clusters of stars.The authors demonstrate that, if the current star formation rates observed in little blue dots were to persist for another 50 Myr before feedback or gas exhaustion halted star production, the little blue dots could form enough stars to create clusters of roughly a million solar masses which is large enough to explain the globular clusters we observe today.If little blue dots indeed rapidly produced such star clusters in the past, the clusters could later be absorbed into the halos of todays spiral and elliptical galaxies, appearing to us as the low-metallicity globular clusters that orbit large galaxies today.CitationDebra Meloy Elmegreen and Bruce G. Elmegreen 2017 ApJL 851 L44. doi:10.3847/2041-8213/aaa0ce

Review of inconsistencies between SUDAS and Iowa DOT specifications.

DOT National Transportation Integrated Search

2006-05-01

The Iowa Department of Transportation's Standard Specifications for Highway and Bridge Construction were originally developed with highway construction in rural areas. As the state continues to develop, an ever-increasing portion of the projects admi...

Non-specific cellular uptake of surface-functionalized quantum dots

NASA Astrophysics Data System (ADS)

Kelf, T. A.; Sreenivasan, V. K. A.; Sun, J.; Kim, E. J.; Goldys, E. M.; Zvyagin, A. V.

2010-07-01

We report a systematic empirical study of nanoparticle internalization into cells via non-specific pathways. The nanoparticles were comprised of commercial quantum dots (QDs) that were highly visible under a fluorescence confocal microscope. Surface-modified QDs with basic biologically significant moieties, e.g. carboxyl, amino, and streptavidin, were used, in combination with surface derivatization with polyethylene glycol (PEG) for a range of immortalized cell lines. Internalization rates were derived from image analysis and a detailed discussion about the effect of nanoparticle size, charge and surface groups is presented. We find that PEG derivatization dramatically suppresses the non-specific uptake while PEG-free carboxyl and amine functional groups promote QD internalization. These uptake variations displayed a remarkable consistency across different cell types. The reported results are important for experiments concerned with cellular uptake of surface-functionalized nanomaterials, both when non-specific internalization is undesirable and when it is intended for material to be internalized as efficiently as possible.

49 CFR 179.221 - Individual specification requirements applicable to tank car tanks consisting of an inner...

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.221 Individual specification... to tank car tanks consisting of an inner container supported within an outer shell. 179.221 Section...

49 CFR 179.221 - Individual specification requirements applicable to tank car tanks consisting of an inner...

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.221 Individual specification... to tank car tanks consisting of an inner container supported within an outer shell. 179.221 Section...

49 CFR 179.201 - Individual specification requirements applicable to non-pressure tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to non-pressure tank car tanks. 179.201 Section 179.201 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201 Individual specification requirements applicable to non-pressure tank car tanks. ...

49 CFR 179.201 - Individual specification requirements applicable to non-pressure tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to non-pressure tank car tanks. 179.201 Section 179.201 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201 Individual specification requirements applicable to non-pressure tank car tanks. ...

49 CFR 179.301 - Individual specification requirements for multi-unit tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-unit tank car tanks. 179.301 Section 179.301 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.301 Individual specification requirements for multi-unit tank car tanks. (a) In addition to...

49 CFR 179.201 - Individual specification requirements applicable to non-pressure tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... to non-pressure tank car tanks. 179.201 Section 179.201 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201 Individual specification requirements applicable to non-pressure tank car tanks. ...

49 CFR 179.301 - Individual specification requirements for multi-unit tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-unit tank car tanks. 179.301 Section 179.301 Transportation Other Regulations Relating to... MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.301 Individual specification requirements for multi-unit tank car tanks. (a) In...

49 CFR 179.400 - General specification applicable to cryogenic liquid tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... liquid tank car tanks. 179.400 Section 179.400 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400 General specification applicable to cryogenic liquid tank car...

49 CFR 179.301 - Individual specification requirements for multi-unit tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-unit tank car tanks. 179.301 Section 179.301 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.301 Individual specification requirements for multi-unit tank car tanks. (a) In addition to...

49 CFR 179.301 - Individual specification requirements for multi-unit tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-unit tank car tanks. 179.301 Section 179.301 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.301 Individual specification requirements for multi-unit tank car tanks. (a) In addition to...

49 CFR 179.400 - General specification applicable to cryogenic liquid tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... liquid tank car tanks. 179.400 Section 179.400 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400 General specification applicable to cryogenic liquid tank car...

49 CFR 179.400 - General specification applicable to cryogenic liquid tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... liquid tank car tanks. 179.400 Section 179.400 Transportation Other Regulations Relating to... (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400 General specification applicable to cryogenic liquid tank car...

49 CFR 179.100-10 - Postweld heat treatment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

49 CFR 179.101 - Individual specification requirements applicable to pressure tank car tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... to pressure tank car tanks. 179.101 Section 179.101 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109...

49 CFR 179.100-10 - Postweld heat treatment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

49 CFR 179.100 - General specifications applicable to pressure tank car tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... car tanks. 179.100 Section 179.100 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120...

49 CFR 179.100-10 - Postweld heat treatment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

49 CFR 179.300 - General specifications applicable to multi-unit tank car tanks designed to be removed from car...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 110AW). 179.300 Section 179.300 Transportation Other Regulations Relating to Transportation PIPELINE AND... SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300...

Comparison between Slow Components of HR and V[Combining Dot Above]O2 Kinetics: Functional Significance.

PubMed

Zuccarelli, Lucrezia; Porcelli, Simone; Rasica, Letizia; Marzorati, Mauro; Grassi, Bruno

2018-03-22

Aerobic exercise prescription is often based on a linear relationship between pulmonary oxygen consumption (V[Combining Dot Above]O2) and heart rate (HR). The aim of the present study was to test the hypothesis that during constant work rate (CWR) exercises at different intensities the slow component of HR kinetics occurs at lower work rate and is more pronounced that the slow component of V[Combining Dot Above]O2 kinetics. Seventeen male (age, 27±4yr) subjects performed on a cycle ergometer an incremental exercise to voluntary exhaustion and several CWR exercises: 1) moderate CWR exercises (MODERATE), below gas exchange threshold (GET); 2) heavy CWR exercise (HEAVY), at 45% of the difference between GET and V[Combining Dot Above]O2 peak (□); 3) severe CWR exercise (SEVERE), at 95% of Δ; 4) "HRCLAMPED" exercise in which work rate was continuously adjusted to maintain a constant HR, slightly higher than that determined at GET. Breath-by-breath V[Combining Dot Above]O2, HR and other variables were determined. In MODERATE, no slow component of V[Combining Dot Above]O2 kinetics was observed, whereas a slow component with a relative amplitude (with respect to the total response) of 24.8±11.0% was observed for HR kinetics. During HEAVY, the relative amplitude of the HR slow component was more pronounced than that for V[Combining Dot Above]O2 (31.6±11.2 and 23.3±9.0%, respectively). During HRCLAMPED the decrease in work rate (~14%) needed in order to maintain a constant HR was associated with a decreased V[Combining Dot Above]O2 (~10%). The HR slow component occurred at a lower work rate and was more pronounced than the V[Combining Dot Above]O2 slow component. Exercise prescriptions at specific HR values, when carried out for periods longer than a few minutes, could lead to premature fatigue.

(Global natural resource monitoring and assessment)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dale, V.H.

1989-10-16

The traveler participated in a major international forestry conference in Venice, Italy, and gave a presentation on the need for monitoring forests on a worldwide basis and a strategy to do so. She also participated in a working group on ways to promote institutional collaboration for global monitoring. Observations from this conference are summarized with focus on issues relating to Oak Ridge National Laboratory's (ORNL's) Center for Global Environmental Studies. The traveler also discussed the possibility of a joint ORNL-Swiss research program to develop a spatial model of forests.

Residential energy demand models: Current status and future improvements

NASA Astrophysics Data System (ADS)

Peabody, G.

1980-12-01

Two models currently used to analyze energy use by the residential sector are described. The ORNL model is used to forecast energy use by fuel type for various end uses on a yearly basis. The MATH/CHRDS model analyzes variations in energy expenditures by households of various socioeconomic and demographic characteristics. The essential features of the ORNL and MATH/CHRDS models are retained in a proposed model and integrated into a framework that is more flexible than either model. The important determinants of energy use by households are reviewed.

18th Annual NDIA SOLIC Symposium and Exhibition - Warfare in the Seams: Defense and Industry Partnering to Win the Long War. Volume 1. Presentations

DTIC Science & Technology

2007-02-28

Program •Services executed Defense HUMINT Activities •DIA ran attaché system •Over time , deferred the Secretary’s Authorities •Post-1995 (Perry and White...ornl.gov orbucma@doe.ic.gov 26 February, 2007 TT L SENSO RS COMMS time trust Intelligence …the power of change… hameleon ORNL Cognitive Radio Program...and internal states in real- time to meet user requirements and goals • Learns: uses statistical signal processing and machine learning to reflect

Minor Scale Event, Test Execution Report

DTIC Science & Technology

1986-01-31

iki the compressed consisted of eight schedule getting to the MINOR SCALE event. Aluminum honey comb ORNL proviced representatives at monthly review...meetings. Their repre- pit wall and the un" sentatives had expertise in the areas of cryogenics design, and instrumentation. ORNL was prepared to...1717 WA K Soi hl Characterizaitom Uo I S I I I 8l U 3E149 Soil sassles is otecarsor gill VA Y Shoew Ii~q S-IUU ft I 1 I 31 iIt It L 7 1 Ut Futed in 871