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Sample records for panel survey meps

  1. The Medical Expenditure Panel Survey (MEPS) experiences with cancer survivorship supplement.

    PubMed

    Yabroff, K Robin; Dowling, Emily; Rodriguez, Juan; Ekwueme, Donatus U; Meissner, Helen; Soni, Anita; Lerro, Catherine; Willis, Gordon; Forsythe, Laura P; Borowski, Laurel; Virgo, Katherine S

    2012-12-01

    The prevalence of cancer survivorship in the USA is expected to increase in the future because the US population is increasing in size and is aging and because survival following diagnosis is improving for many types of cancer. Medical care costs associated with cancer are also projected to increase dramatically. However, currently available data for estimating medical care costs and other important aspects of the burden of cancer, including time spent receiving medical care, productivity loss due to morbidity for patients and their families, and financial hardship, are limited, particularly in the population under the age of 65. We describe selected publicly available data sources for estimating the burden of cancer in the USA and a new collaborative effort to improve the quality of these data: the nationally representative Medical Expenditure Panel Survey (MEPS) Experiences with Cancer Survivorship Supplement. Data from this effort can be used to address key gaps in cancer survivorship research related to medical care costs, employment patterns, financial hardship, and other aspects of the burden of illness for cancer survivors and their families. Research using the MEPS Experiences with Cancer Survivorship Supplement can inform efforts by health care policy makers, healthcare systems, providers, and employers to improve the cancer survivorship experience in the USA.

  2. Identifying Episodes of Back Pain Using Medical Expenditures Panel Survey (MEPS) Data: Patient Experience, Use of Services, and Chronicity

    PubMed Central

    Monica, Smith

    2010-01-01

    Objective To explore the correspondence between “episodes of pain” and “episodes of care” for individuals with back pain. Data Source Secondary analysis of Medical Expenditures Panel Survey (MEPS) 2-year longitudinal data. Study Design Individual use and utilization of back pain services were examined across ambulatory settings and providers, and linked to MEPS medical condition data to identify individuals with back pain who do not use, or who delay or discontinue utilization of health services for back pain. Data Collection/Extraction Methods Episodes-of-care and episodes-of-pain were approximated through round-by-round temporal mapping of MEPS back pain utilization events data and medical conditions data. Principal Findings Of 10,193 individuals with back pain, approximately one fifth did not actively seek care for their back pain. Utilization of services for back pain (episodes-of-care) does not always correspond with an individual’s full experience of back pain (episodes-of-pain). Upwards of 20% of MEPS respondents who use services for some back pain episodes, reported additional episodes for which they do not use services. Conclusions These findings suggest that other longitudinal studies based only on data that reflect service use, e.g., claims data, may incorrectly infer the nature of back pain and back pain episodes. Many individuals report ongoing back pain that continues beyond their episodes-of-care, and many individuals with persistent back pain may use prescription drugs, medical services, and other health services only intermittently. PMID:21036278

  3. The relationship of disability and employment for veterans from the 2010 Medical Expenditure Panel Survey (MEPS).

    PubMed

    Smith, Diane L

    2015-06-05

    Veterans with disabilities, especially those with posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) have difficulty obtaining and maintaining competitive employment. To determine if there are significant differences in employment between veterans with and without disability, between veterans with a disability and nonveterans with a disability, and to investigate the association of veteran status and disability with employment. Chi square analyses were conducted on data obtained from the 2010 Medical Expenditure Panel Survey to determine if significant differences in employment occurred between veterans with disabilities, veterans without disabilities and nonveterans with disabilities. Multivariate regression analyses were used to determine how veteran status and disability are associated with employment. Significant differences in employment were found between veterans with and without a disability; however, no significant differences existed in employment between veterans and nonveterans with a disability. Multivariate analysis showed that veteran status (aOR=1.80), having any disability (aOR=7.29), social disability (aOR=3.47) or a cognitive disability (aOR=3.16) were associated with not being employed. Veterans with disabilities are more likely not to be employed than veteran populations without disabilities. Veterans; however have unique disabilities, different than nonveterans with disabilities, that need to be addressed, such as social and cognitive disabilities resulting from TBI and PTSD. Future research should focus on evaluating the effectiveness of employment programs and policies designed to address the unique issues faced by veterans with disabilities.

  4. Health Care Use, Health Behaviors, and Medical Conditions Among Individuals in Same-Sex and Opposite-Sex Partnerships: A Cross-Sectional Observational Analysis of the Medical Expenditures Panel Survey (MEPS), 2003-2011.

    PubMed

    Blosnich, John R; Hanmer, Janel; Yu, Lan; Matthews, Derrick D; Kavalieratos, Dio

    2016-06-01

    Prior research documents disparities between sexual minority and nonsexual minority individuals regarding health behaviors and health services utilization. However, little is known regarding differences in the prevalence of medical conditions. To examine associations between sexual minority status and medical conditions. We conducted multiple logistic regression analyses of the Medical Expenditure Panel Survey (2003-2011). We identified individuals who reported being partnered with an individual of the same sex, and constructed a matched cohort of individuals in opposite-sex partnerships. A total of 494 individuals in same-sex partnerships and 494 individuals in opposite-sex partnerships. Measures of health risk (eg, smoking status), health services utilization (eg, physician office visits), and presence of 15 medical conditions (eg, cancer, diabetes, arthritis, HIV, alcohol disorders). Same-sex partnered men had nearly 4 times the odds of reporting a mood disorder than did opposite-sex partnered men [adjusted odds ratio (aOR)=3.96; 95% confidence interval (CI), 1.85-8.48]. Compared with opposite-sex partnered women, same-sex partnered women had greater odds of heart disease (aOR=2.59; 95% CI, 1.19-5.62), diabetes (aOR=2.75; 95% CI, 1.10-6.90), obesity (aOR=1.92; 95% CI, 1.26-2.94), high cholesterol (aOR=1.89; 95% CI, 1.03-3.50), and asthma (aOR=1.90; 95% CI, 1.02-1.19). Even after adjusting for sociodemographics, health risk behaviors, and health conditions, individuals in same-sex partnerships had 67% increased odds of past-year emergency department utilization and 51% greater odds of ≥3 physician visits in the last year compared with opposite-sex partnered individuals. A combination of individual-level, provider-level, and system-level approaches are needed to reduce disparities in medical conditions and health care utilization among sexual minority individuals.

  5. 76 FR 43264 - Proposed Information Collection; Comment Request; NIST MEP Client Impact Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-20

    ... National Institute of Standards and Technology Proposed Information Collection; Comment Request; NIST MEP Client Impact Survey AGENCY: National Institute of Standards and Technology (NIST), Commerce. ACTION...@nist.gov . SUPPLEMENTARY INFORMATION: I. Abstract Sponsored by the National Institute of Standards and...

  6. The capacity of the Medical Expenditure Panel Survey to inform the Affordable Care Act.

    PubMed

    Cohen, Steven B; Cohen, Joel W

    2013-05-01

    The Affordable Care Act (ACA) was enacted with major provisions to expand health insurance coverage, control health care costs, and improve the health care delivery system. Essential data resources will be required for effective program planning, administration, and management, in addition to facilitating evaluations of program performance. The Medical Expenditure Panel Survey (MEPS) is one of the core data resources that has been used to inform several provisions of the ACA. This paper provides a summary of the capacity of the MEPS to inform program planning, implementation, and evaluations of program performance for several components of the ACA.

  7. Use of Internet panels to conduct surveys.

    PubMed

    Hays, Ron D; Liu, Honghu; Kapteyn, Arie

    2015-09-01

    The use of Internet panels to collect survey data is increasing because it is cost-effective, enables access to large and diverse samples quickly, takes less time than traditional methods to obtain data for analysis, and the standardization of the data collection process makes studies easy to replicate. A variety of probability-based panels have been created, including Telepanel/CentERpanel, Knowledge Networks (now GFK KnowledgePanel), the American Life Panel, the Longitudinal Internet Studies for the Social Sciences panel, and the Understanding America Study panel. Despite the advantage of having a known denominator (sampling frame), the probability-based Internet panels often have low recruitment participation rates, and some have argued that there is little practical difference between opting out of a probability sample and opting into a nonprobability (convenience) Internet panel. This article provides an overview of both probability-based and convenience panels, discussing potential benefits and cautions for each method, and summarizing the approaches used to weight panel respondents in order to better represent the underlying population. Challenges of using Internet panel data are discussed, including false answers, careless responses, giving the same answer repeatedly, getting multiple surveys from the same respondent, and panelists being members of multiple panels. More is to be learned about Internet panels generally and about Web-based data collection, as well as how to evaluate data collected using mobile devices and social-media platforms.

  8. Use of Internet Panels to Conduct Surveys

    PubMed Central

    Hays, Ron D.; Liu, Honghu; Kapteyn, Arie

    2015-01-01

    Use of internet panels to collect survey data is increasing because it is cost-effective, enables access to large and diverse samples quickly, takes less time than traditional methods to obtain back for analysis, and the standardization of data collection process makes studies easy to replicate. A variety of probability-based panels have been created including Telepanel/CentERpanel, Knowledge Networks (now GFK KnowledgePanel®), the American Life Panel, the LISS Panel, and the Understanding American Study panel. Despite the advantage of having a known denominator (sampling frame), the probability-based internet panels often have low recruitment participation rates and some have argued that there is little practical difference between opting out of a probability sample and opting into a non-probability (convenience) internet panel. This paper provides an overview of both probability-based and convenience panels, discussing potential benefits and cautions for each method, and summarizing approaches used to weight panel respondents to better represent the underlying population. Challenges in using internet panel data such as false answers, careless responses, giving the same answer repeatedly, getting multiple surveys from the same respondent, and panelists being members of multiple panels are discussed. There is more to be learned about internet panels generally and web-based data collection along with opportunities to evaluate data collected using mobile devices and social media platforms. PMID:26170052

  9. Reconciling Medical Expenditure Estimates from the MEPS and NHEA, 2007

    PubMed Central

    Bernard, Didem; Cowan, Cathy; Selden, Thomas; Cai, Liming; Catlin, Aaron; Heffler, Stephen

    2012-01-01

    Objective Provide a comparison of health care expenditure estimates for 2007 from the Medical Expenditure Panel Survey (MEPS) and the National Health Expenditure Accounts (NHEA). Reconciling these estimates serves two important purposes. First, it is an important quality assurance exercise for improving and ensuring the integrity of each source's estimates. Second, the reconciliation provides a consistent baseline of health expenditure data for policy simulations. Our results assist researchers to adjust MEPS to be consistent with the NHEA so that the projected costs as well as budgetary and tax implications of any policy change are consistent with national health spending estimates. Data Sources The Medical Expenditure Panel Survey produced by the Agency for Healthcare Research and Quality, and the National Health Center for Health Statistics and the National Health Expenditures produced by the Centers for Medicare & Medicaid Service's Office of the Actuary. Results In this study, we focus on the personal health care (PHC) sector, which includes the goods and services rendered to treat or prevent a specific disease or condition in an individual. The official 2007 NHEA estimate for PHC spending is $1,915 billion and the MEPS estimate is $1,126 billion. Adjusting the NHEA estimates for differences in underlying populations, covered services, and other measurement concepts reduces the NHEA estimate for 2007 to $1,366 billion. As a result, MEPS is $240 billion, or 17.6 percent, less than the adjusted NHEA total. PMID:24800157

  10. Panel Conditioning in the General Social Survey

    ERIC Educational Resources Information Center

    Halpern-Manners, Andrew; Warren, John Robert; Torche, Florencia

    2017-01-01

    Does participation in one wave of a survey have an effect on respondents' answers to questions in subsequent waves? In this article, we investigate the presence and magnitude of "panel conditioning" effects in one of the most frequently used data sets in the social sciences: the General Social Survey (GSS). Using longitudinal records…

  11. A Flexible Model for Correlated Medical Costs, with Application to Medical Expenditure Panel Survey Data

    PubMed Central

    Chen, Jinsong; Liu, Lei; Shih, Ya-Chen T.; Zhang, Daowen; Severini, Thomas A.

    2016-01-01

    We propose a flexible model for correlated medical cost data with several appealing features. First, the mean function is partially linear. Second, the distributional form for the response is not specified. Third, the covariance structure of correlated medical costs has a semiparametric form. We use extended generalized estimating equations to simultaneously estimate all parameters of interest. B-splines is used to estimate unknown functions, and a modification to Akaike Information Criterion is proposed for selecting knots in spline bases. We apply the model to correlated medical costs in the Medical Expenditure Panel Survey (MEPS) dataset. Simulation studies are conducted to assess the performance of our method. PMID:26403805

  12. Latent Causal Structures in Panel Surveys.

    ERIC Educational Resources Information Center

    Wolfle, Lee M.; Robertshaw, Dianne

    Since measurement errors exist in panel surveys, LISREL (a procedure for controlling measurement error by the analysis of covariance structures) was used in this investigation to determine the stability of the social-psychological concept of locus of control expectancy change with the aquisition of post secondary education. The National…

  13. Work-related injuries among Hispanic construction workers-evidence from the medical expenditure panel survey.

    PubMed

    Dong, Xiuwen Sue; Men, Yurong; Ringen, Knut

    2010-06-01

    Although a large number of Hispanic workers have entered the construction industry, few studies have estimated non-fatal work-related injuries for Hispanic construction workers at a national level. This study examines work-related injury conditions among Hispanic construction workers and assesses disparities between Hispanic and white, non-Hispanic workers. Pooled data were analyzed from a large national population survey, the Medical Expenditure Panel Survey (MEPS), between 1996 and 2002. More than 7,000 construction workers were identified from the MEPS data including 1,833 Hispanic workers and 4,533 white, non-Hispanic workers. Univariate and multivariate analyses were conducted using SAS-callable SUDAAN. Hispanic workers differ from white, non-Hispanic workers in demographic and socioeconomic status. After controlling for major risk factors, Hispanic construction workers were more likely than their white, non-Hispanic counterparts to suffer non-fatal work-related injury conditions (OR = 1.28, 95% CI: 1.00-1.64). This study provides important evidence concerning Hispanic workers' safety on construction sites. Enhanced safety and health programs for Hispanic construction workers and improved occupational injury data systems are recommended. 2010 Wiley-Liss, Inc.

  14. Chronic Disease Prevalence and Medicare Advantage Market Penetration: Findings From the Medical Expenditure Panel Survey.

    PubMed

    Howard, Steven W; Bernell, Stephanie Lazarus; Casim, Faizan M; Wilmott, Jennifer; Pearson, Lindsey; Byler, Caitlin M; Zhang, Zidong

    2015-01-01

    By March 2015, 30% of all Medicare beneficiaries were enrolled in Medicare Advantage (MA) plans. Research to date has not explored the impacts of MA market penetration on individual or population health outcomes. The primary objective of this study is to examine the relationships between MA market penetration and the beneficiary's portfolio of cardiometabolic diagnoses. This study uses 2004 to 2008 Medical Expenditure Panel Survey (MEPS) Household Component data to construct an aggregate index that captures multiple diagnoses in one outcome measure (Chronic Disease Severity Index [CDSI]). The MEPS data for 8089 Medicare beneficiaries are merged with MA market penetration data from Centers for Medicare and Medicaid Services (CMS). Ordinary least squares regressions are run with SAS 9.3 to model the effects of MA market penetration on CDSI. The results suggest that each percentage increase in MA market penetration is associated with a greater than 2-point decline in CDSI (lower burden of cardiometabolic chronic disease). Spill-over effects may be driving improvements in the cardiometabolic health of beneficiary populations in counties with elevated levels of MA market penetration.

  15. Determinants and trends in dental expenditures in the adult US population: Medical Expenditure Panel Survey 1996-2006.

    PubMed

    Christian, B; Chattopadhyay, A

    2014-06-01

    To estimate dental expenditures in 2006, to analyse dental expenditures by potential explanatory factors for 2006 and to explore trends in dental expenditures from 1996-2006. Medical Expenditure Panel Survey (MEPS) data were used. T-tests and analysis of variance were used to test for significance. Multivariable linear regression analysis was conducted to identify independent predictors of dental expenditures. The trend analysis was conducted for the 11-year period, 1996-2006, on adults aged 25 years and older. Expenditures were inflation adjusted to 2006 dollars using the annual average Consumer Price Index. Data were analysed using the MEPS query tool and SASv9.2. In the 2006 MEPS sample, 8,001 adults had dental expenditures and when weighted represented about 93 million non-institutionalised adult US civilians. The mean dental expenditures for this weighted sample were $611 (sd 1,309), median $233 (inter-quartile range 466). As expected, in 2006, dental expenditures increased with age. Those adults who reported their self-perceived health status as 'excellent' were observed to have lowest dental expenditures in this category. After adjusting for other variables in the multivariable linear regression analysis of dental expenditures, age, race/ethnicity, income, geographic location, perceived health status and dental insurance coverage remained significant. Dental expenditures for 2006 were $611 (mean) and $233 (median). The time-trend showed substantial but non-uniform annual changes in real dental expenditures between 1996 and 2006.

  16. The medical home, preventive care screenings, and counseling for children: evidence from the Medical Expenditure Panel Survey.

    PubMed

    Romaire, Melissa A; Bell, Janice F

    2010-01-01

    Little is known about the role of the medical home in promoting essential preventive health care services in the general pediatric population. This study examined associations between having a medical home and receipt of health screenings and anticipatory guidance. We conducted a cross-sectional analysis of the 2004-2006 Medical Expenditure Panel Survey (MEPS). Our sample included 21 055 children aged 0 to 17 years who visited a health care provider in the year prior to the survey. A binary indicator of the medical home was developed from 22 questions in MEPS, reflecting 4 of the 7 American Academy of Pediatrics' recommended components of the medical home: accessible, family-centered, comprehensive, and compassionate care. Multivariable logistic regression was used to examine the association between the medical home and receipt of specific health screenings and anticipatory guidance, controlling for confounding variables. Approximately 49% of our study sample has a medical home. The medical home, defined when the usual source of care is a person or facility, is significantly associated with 3 health screenings (ie, weight, height, and blood pressure) and several anticipatory guidance topics (ie, advice about dental checkups, diet, exercise, car and bike safety), with odds ratios ranging from 1.26 to 1.54. The medical home is associated with increased odds of children receiving some health screenings and anticipatory guidance. The medical home may provide an opportunity to improve the delivery of these services for children. Copyright 2010 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  17. Disparities in Health Care Access and Receipt of Preventive Services by Disability Type: Analysis of the Medical Expenditure Panel Survey

    PubMed Central

    Horner-Johnson, Willi; Dobbertin, Konrad; Lee, Jae Chul; Andresen, Elena M

    2014-01-01

    Objective To examine differences in access to health care and receipt of clinical preventive services by type of disability among working-age adults with disabilities. Data Source Secondary analysis of Medical Expenditure Panel Survey (MEPS) data from 2002 to 2008. Study Design We conducted cross-sectional logistic regression analyses comparing people with different types of disabilities on health insurance status and type; presence of a usual source of health care; delayed or forgone care; and receipt of dental checkups and cancer screening. Data Collection We pooled annualized MEPS data files across years. Our analytic sample consisted of adults (18–64 years) with physical, sensory, or cognitive disabilities and nonmissing data for all variables of interest. Principal Findings Individuals with hearing impairment had better health care access and receipt than people with other disability types. People with multiple types of limitations were especially likely to have health care access problems and unmet health care needs. Conclusions There are differences in health care access and receipt of preventive care depending on what type of disability people have. More in-depth research is needed to identify specific causes of these disparities and assess interventions to address health care barriers for particular disability groups. PMID:24962662

  18. Effect of involvement level on mail panel survey response rates

    Treesearch

    Mark E. Havitz; Dennis R. Howard

    1995-01-01

    A panel survey of golfers, skiers and windsurfers was conducted using mail questionnaires which were distributed three times over the course of a calendar year; in-season, off-season, and preseason. Respondents' levels of enduring activity involvement were measured using Laurent and Kapferer's (1985) Involvement Profile scale. No support was found for the...

  19. 77 FR 21086 - Patents External Quality Survey (formerly Customer Panel Quality Survey)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... United States Patent and Trademark Office Patents External Quality Survey (formerly Customer Panel Quality Survey) ACTION: Proposed collection; comment request. SUMMARY: The United States Patent and...@uspto.gov . Include ``0651- 0057 Patents External Quality Survey comment'' in the subject line of...

  20. Aging Baby Boomers and the Rising Cost of Chronic Back Pain: Secular Trend Analysis of Longitudinal Medical Expenditures Panel Survey Data for Years 2000 to 2007

    PubMed Central

    Smith, Monica; Davis, Matthew A.; Stano, Miron; Whedon, James M.

    2013-01-01

    Objectives The purposes of this study were to analyze data from the longitudinal Medical Expenditures Panel Survey (MEPS) to evaluate the impact of an aging population on secular trends in back pain and chronicity and to provide estimates of treatment costs for patients who used only ambulatory services. Methods Using the MEPS 2-year longitudinal data for years 2000 to 2007, we analyzed data from all adult respondents. Of the total number of MEPS respondent records analyzed (N = 71 838), we identified 12 104 respondents with back pain and further categorized 3842 as chronic cases and 8262 as nonchronic cases. Results Secular trends from the MEPS data indicate that the prevalence of back pain has increased by 29%, whereas chronic back pain increased by 64%. The average age among all adults with back pain increased from 45.9 to 48.2 years; the average age among adults with chronic back pain increased from 48.5 to 52.2 years. Inflation-adjusted (to 2010 dollars) biennial expenditures on ambulatory services for chronic back pain increased by 129% over the same period, from $15.6 billion in 2000 to 2001 to $35.7 billion in 2006 to 2007. Conclusion The prevalence of back pain, especially chronic back pain, is increasing. To the extent that the growth in chronic back pain is caused, in part, by an aging population, the growth will likely continue or accelerate. With relatively high cost per adult with chronic back pain, total expenditures associated with back pain will correspondingly accelerate under existing treatment patterns. This carries implications for prioritizing health policy, clinical practice, and research efforts to improve care outcomes, costs, and cost-effectiveness and for health workforce planning. PMID:23380209

  1. Private dental and prescription-drug coverage in children: data from the medical expenditure panel survey.

    PubMed

    Chen, Alex Y

    2004-01-01

    Most studies on health insurance have examined primarily basic medical insurance coverage; few have looked at supplemental insurance and/or dental-insurance coverage. Prescription-drug and dental-insurance coverage are becoming increasingly important due to continued increase in health care costs and changes in cost-sharing structure of health plans. This study examined prescription-drug coverage and dental-insurance coverage in the context of overall insurance coverage. This study utilized the Household Component File from the 2000 Medical Expenditure Panel Survey (MEPS), a national survey on medical care conducted by the Agency for Healthcare Research and Quality (AHRQ). Univariate and bivariate analyses were performed to provide estimates on children's prescription-drug and dental-insurance coverage. Multivariate logistic regression analyses were conducted to identify demographic and socioeconomic factors that influence coverage. In 2000, 68.5% of US children had private insurance, 22.2% had public insurance, and 9.3% were uninsured. Among children with private insurance, only 56.9% had dental-insurance coverage and 76.3% had prescription-drug coverage. Family income level, maternal education, and race were significant predictors of dental insurance and prescription-drug coverage. Although significant strides have been made to insure US children, a large percentage of children still do not have comprehensive coverage. Even among privately insured children, many are without dental or prescription-drug coverage. Those who were poor, minority, and with low maternal education had lower likelihood of dental and prescription-drug coverage.

  2. Favorable Cardiovascular Risk Profile Is Associated With Lower Healthcare Costs and Resource Utilization: The 2012 Medical Expenditure Panel Survey.

    PubMed

    Valero-Elizondo, Javier; Salami, Joseph A; Ogunmoroti, Oluseye; Osondu, Chukwuemeka U; Aneni, Ehimen C; Malik, Rehan; Spatz, Erica S; Rana, Jamal S; Virani, Salim S; Blankstein, Ron; Blaha, Michael J; Veledar, Emir; Nasir, Khurram

    2016-03-01

    The American Heart Association's 2020 Strategic Goals emphasize the value of optimizing risk factor status to reduce the burden of morbidity and mortality. In this study, we aimed to quantify the overall and marginal impact of favorable cardiovascular risk factor (CRF) profile on healthcare expenditure and resource utilization in the United States among those with and without cardiovascular disease (CVD). The study population was derived from the 2012 Medical Expenditure Panel Survey (MEPS). Direct and indirect costs were calculated for all-cause healthcare resource utilization. Variables of interest included CVD diagnoses (coronary artery disease, stroke, peripheral artery disease, dysrhythmias, or heart failure), ascertained by International Classification of Diseases, Ninth Edition, Clinical Modification codes, and CRF profile (hypertension, diabetes mellitus, hypercholesterolemia, smoking, physical activity, and obesity). Two-part econometric models were used to study expenditure data. The final study sample consisted of 15 651 MEPS participants (58.5±12 years, 54% female). Overall, 5921 (37.8%) had optimal, 7002 (44.7%) had average, and 2728 (17.4%) had poor CRF profile, translating to 54.2, 64.1, and 24.9 million adults in United States, respectively. Significantly lower health expenditures were noted with favorable CRF profile across CVD status. Among study participants with established CVD, overall healthcare expenditures with optimal and average CRF profile were $5946 and $3731 less compared with those with poor CRF profile. The respective differences were $4031 and $2560 in those without CVD. Favorable CRF profile is associated with significantly lower medical expenditure and healthcare utilization among individuals with and without established CVD. © 2016 American Heart Association, Inc.

  3. Clarifying the Predictive Value of Family-Centered Care and Shared Decision Making for Pediatric Healthcare Outcomes Using the Medical Expenditure Panel Survey.

    PubMed

    Lindly, Olivia J; Zuckerman, Katharine E; Mistry, Kamila B

    2017-02-01

    To estimate (1) family-centered care (FCC) and shared decision-making (SDM) prevalence, and (2) associations of FCC and SDM (FCC/SDM) with health care outcomes among U.S. children. The Medical Expenditure Panel Survey Household Component (MEPS-HC), a nationally representative survey of the noninstitutionalized, civilian population. Secondary analyses of prospectively collected data on 15,764 U.S. children were conducted to examine FCC/SDM prevalence in year 1 and associations of FCC/SDM in year 1 with health services utilization, medical expenditures, and unmet health care needs in year 2. We combined four MEPS-HC longitudinal files from 2007 to 2011. FCC/SDM prevalence in year 1 varied from 38.6 to 93.7 percent, and it was lower for composites with more stringent scoring approaches. FCC/SDM composites with stringent scoring approaches in year 1 were associated with reduced unmet needs in year 2. FCC/SDM, across all year 1 composites, was not associated with health services utilization or medical expenditures in year 2. FCC/SDM year 1 subcomponents describing consensus building and mutual agreement were consistently associated with unmet health care needs in year 2. FCC/SDM composites with stringent scoring approaches measuring consensus building and mutual agreement may have the greatest utility for pediatric health care quality improvement efforts. © Health Research and Educational Trust.

  4. A Note on Improving Process Efficiency in Panel Surveys with Paradata

    ERIC Educational Resources Information Center

    Kreuter, Frauke; Müller, Gerrit

    2015-01-01

    Call scheduling is a challenge for surveys around the world. Unlike cross-sectional surveys, panel surveys can use information from prior waves to enhance call-scheduling algorithms. Past observational studies showed the benefit of calling panel cases at times that had been successful in the past. This article is the first to experimentally assign…

  5. Evaluating direct medical expenditures estimation methods of adults using the medical expenditure panel survey: an example focusing on head and neck cancer.

    PubMed

    Coughlan, Diarmuid; Yeh, Susan T; O'Neill, Ciaran; Frick, Kevin D

    2014-01-01

    To inform policymakers of the importance of evaluating various methods for estimating the direct medical expenditures for a low-incidence condition, head and neck cancer (HNC). Four methods of estimation have been identified: 1) summing all health care expenditures, 2) estimating disease-specific expenditures consistent with an attribution approach, 3) estimating disease-specific expenditures by matching, and 4) estimating disease-specific expenditures by using a regression-based approach. A literature review of studies (2005-2012) that used the Medical Expenditure Panel Survey (MEPS) was undertaken to establish the most popular expenditure estimation methods. These methods were then applied to a sample of 120 respondents with HNC, derived from pooled data (2003-2008). The literature review shows that varying expenditure estimation methods have been used with MEPS but no study compared and contrasted all four methods. Our estimates are reflective of the national treated prevalence of HNC. The upper-bound estimate of annual direct medical expenditures of adult respondents with HNC between 2003 and 2008 was $3.18 billion (in 2008 dollars). Comparable estimates arising from methods focusing on disease-specific and incremental expenditures were all lower in magnitude. Attribution yielded annual expenditures of $1.41 billion, matching method of $1.56 billion, and regression method of $1.09 billion. This research demonstrates that variation exists across and within expenditure estimation methods applied to MEPS data. Despite concerns regarding aspects of reliability and consistency, reporting a combination of the four methods offers a degree of transparency and validity to estimating the likely range of annual direct medical expenditures of a condition. © 2013 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Published by International Society for Pharmacoeconomics and Outcomes Research (ISPOR) All rights reserved.

  6. Out-of-Pocket Spending for Ambulatory Physical Therapy Services From 2008 to 2012: National Panel Survey.

    PubMed

    Chevan, Julia; Riddle, Daniel L; Reed, Shelby D

    2015-12-01

    Out-of-pocket (OOP) expenditures are incurred as insurers and employers shift some of the burden of health care costs onto consumers. As cost-sharing increases, OOP expenditures could be a barrier to physical therapy care. The purposes of this study were: (1) to identify factors associated with any OOP physical therapy spending and (2) to identify factors associated with higher spending among individuals incurring OOP costs. The study was a retrospective analysis using the 4 most recently available panels of data from the Medical Expenditure Panel Survey (MEPS) encompassing 2008-2012. A data file containing episodes of physical therapy care for 2,189 people was created. Logistic regression was used to identify factors related to having an OOP expenditure. A multivariable generalized linear model was used to identify factors related to mean OOP expenditures. On average, an episode of care encompassed 9.9 visits, with mean total expenditures of $1,708 (median: $792). Fifty-four percent of episodes of care had an OOP expenditure. For individuals with OOP expenditures, the mean OOP expenditure for an episode of care was $351 (median: $144). Being female or non-Hispanic and having a higher income were associated with higher odds of incurring an OOP expenditure, whereas being in worse general health, >65 years of age, or nonwhite and having public funding were associated with lower odds of incurring an OOP expenditure. Amounts of OOP spending were higher in urban areas and in all census geographic regions relative to the Northeast region. Estimates are based on household-reported survey data, limited to ambulatory care, and do not include institutionalized individuals. At 54%, the proportion of individuals with OOP expenditures for physical therapy is lower than for general medical care. Several predictors were found of having OOP expenditures and of the magnitude of those expenditures. © 2015 American Physical Therapy Association.

  7. Incremental direct medical expenditures associated with anxiety disorders for the U.S. adult population: evidence from the Medical Expenditure Panel Survey.

    PubMed

    Shirneshan, Elaheh; Bailey, Jim; Relyea, George; Franklin, Brandi E; Solomon, David K; Brown, Lawrence M

    2013-10-01

    Data from the 2009 and 2010 Medical Expenditure Panel Survey (MEPS) were used to estimate the annual incremental healthcare expenditures associated with anxiety disorders, for the ambulatory adult population of the U.S. Individuals 18 years and older, who reported a diagnosis of, or had a medical event associated with anxiety disorder(s), were classified as anxiety population. Multivariate regression analyses, using generalized linear models, were conducted to calculate incremental costs associated with anxiety disorders. 8.74% of adult respondents reported being diagnosed with anxiety disorder(s). The annual overall healthcare expenditure associated with anxiety disorders was estimated at $1657.52 per person (SE: $238.83; p<0.001). Inpatient visits, prescription medications, and office-based visits together accounted for almost 93% of the overall cost. Given the prevalence of self-reported anxiety disorders in MEPS, their total direct medical expenditure is estimated at approximately $33.71 billion in 2013 US dollars, meaning this category of mental illnesses absorbs a significant portion of the U.S. healthcare resources. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Chronic Pain and Health Care Spending: An Analysis of Longitudinal Data from the Medical Expenditure Panel Survey

    PubMed Central

    Stockbridge, Erica L; Suzuki, Sumihiro; Pagán, José A

    2015-01-01

    Objective To estimate average incremental health care expenditures associated with chronic pain by health care service category, expanding on prior research that focused on specific pain conditions instead of general pain, excluded low levels of pain, or did not incorporate pain duration. Data Source Medical Expenditure Panel Survey (MEPS) data (2008–2011; N = 26,671). Study Design Differences in annual expenditures for adults at different levels of pain that interferes with normal work, as measured by the SF-12, were estimated using recycled predictions from two-part logit-generalized linear regression models. Principal Findings “A little bit” of chronic pain-related interference was associated with a $2,498 increase in total adjusted expenditures over no pain interference (p < .0001) and a $1,008 increase over nonchronic pain interference (p = .0001). Moderate and severe chronic pain-related interference was associated with a $3,707 and $5,804 increase in expenditures over no pain interference and a $2,218 and $4,315 increase over nonchronic interference, respectively (p < .0001). Expenditure increases were most pronounced for inpatient and hospital outpatient expenditures compared to other types of health care expenditures. Conclusions Chronic pain limitations are associated with higher health care expenditures. Results underscore the substantial cost of pain to the health care system. PMID:25424348

  9. Chronic pain and health care spending: an analysis of longitudinal data from the Medical Expenditure Panel Survey.

    PubMed

    Stockbridge, Erica L; Suzuki, Sumihiro; Pagán, José A

    2015-06-01

    To estimate average incremental health care expenditures associated with chronic pain by health care service category, expanding on prior research that focused on specific pain conditions instead of general pain, excluded low levels of pain, or did not incorporate pain duration. Medical Expenditure Panel Survey (MEPS) data (2008-2011; N = 26,671). Differences in annual expenditures for adults at different levels of pain that interferes with normal work, as measured by the SF-12, were estimated using recycled predictions from two-part logit-generalized linear regression models. "A little bit" of chronic pain-related interference was associated with a $2,498 increase in total adjusted expenditures over no pain interference (p < .0001) and a $1,008 increase over nonchronic pain interference (p = .0001). Moderate and severe chronic pain-related interference was associated with a $3,707 and $5,804 increase in expenditures over no pain interference and a $2,218 and $4,315 increase over nonchronic interference, respectively (p < .0001). Expenditure increases were most pronounced for inpatient and hospital outpatient expenditures compared to other types of health care expenditures. Chronic pain limitations are associated with higher health care expenditures. Results underscore the substantial cost of pain to the health care system. © Health Research and Educational Trust.

  10. CRRES Microelectronics Test Package (MEP)

    NASA Astrophysics Data System (ADS)

    Mullen, E. G.; Ray, K. P.

    1993-04-01

    The Microelectronics Test Package (MEP) flown on board the Combined Release and Radiation Effects Satellite (CRRES) contained over 60 device types and approximately 400 total devices which were tested for both single event upset (SEU) and total dose (parametric degradation and annealing). A description of the experiment, the method of testing devices, and the structure of data acquisition are presented. Sample flight data are shown. These included SEUs from a GaAs 1 K RAM during the March 1991 solar flare, and a comparison between passive shielding and a specially designed spot shielding package.

  11. CRRES microelectronics test package (MEP)

    SciTech Connect

    Mullen, E.G.; Ray, K.P. )

    1993-04-01

    The Microelectronics Test Package (MEP) flown on board the Combined Release and Radiation Effects Satellite (CRRES) contained over 60 device types and approximately 400 total devices which were tested for both single event upset (SEU) and total dose (parametric degradation and annealing). A description of the experiment, the method of testing devices, and the structure of data acquisition are presented. Sample flight data are shown. These included SEUs from a GaAs 1 K RAM during the March 1991 solar flare, and a comparison between passive shielding and a specially designed spot shielding package.

  12. Selection bias of Internet panel surveys: a comparison with a paper-based survey and national governmental statistics in Japan.

    PubMed

    Tsuboi, Satoshi; Yoshida, Honami; Ae, Ryusuke; Kojo, Takao; Nakamura, Yosikazu; Kitamura, Kunio

    2015-03-01

    To investigate the selection bias of an Internet panel survey organized by a commercial company. A descriptive study was conducted. The authors compared the characteristics of the Internet panel survey with a national paper-based survey and with national governmental statistics in Japan. The participants in the Internet panel survey were composed of more women, were older, and resided in large cities. Regardless of age and sex, the prevalence of highly educated people in the Internet panel survey was higher than in the paper-based survey and the national statistics. In men, the prevalence of heavy drinkers among the 30- to 49-year-old population and of habitual smokers among the 20- to 49-year-old population in the Internet panel survey was lower than what was found in the national statistics. The estimated characteristics of commercial Internet panel surveys were quite different from the national statistical data. In a commercial Internet panel survey, selection bias should not be underestimated. © 2012 APJPH.

  13. 32 CFR 1602.16 - MEPS.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false MEPS. 1602.16 Section 1602.16 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.16 MEPS. A Military Entrance Processing Station is a military installation to which registrants are ordered to report...

  14. 32 CFR 1602.16 - MEPS.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false MEPS. 1602.16 Section 1602.16 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.16 MEPS. A Military Entrance Processing Station is a military installation to which registrants are ordered to report...

  15. 32 CFR 1602.16 - MEPS.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false MEPS. 1602.16 Section 1602.16 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.16 MEPS. A Military Entrance Processing Station is a military installation to which registrants are ordered to...

  16. Personality Measurement and Assessment in Large Panel Surveys*

    PubMed Central

    Roberts, Brent; Jackson, Joshua J.; Duckworth, Angela L.; Von Culin, Katherine

    2013-01-01

    Personality tests are being added to large panel studies with increasing regularity, such as the Health and Retirement Study (HRS). To facilitate the inclusion and interpretation of these tests, we provide some general background on personality psychology, personality assessment, and the validity of personality tests. In this review, we provide background on definitions of personality, the strengths and weaknesses of the self-report approaches to personality testing typically used in large panel studies, and the validity of personality tests for three outcomes: genetics, income, and health. We conclude with recommendations on how to improve personality assessment in future panel studies. PMID:23503719

  17. Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus.

    PubMed

    Schindler, Bryan D; Seo, Susan M; Birukou, Ivan; Brennan, Richard G; Kaatz, Glenn W

    2015-03-01

    The expression of mepA, encoding the Staphylococcus aureus MepA multidrug efflux protein, is repressed by the MarR homologue MepR. Repression occurs through binding of two MepR dimers to an operator with two homologous and closely approximated pseudopalindromic binding sites (site 1 [S1] and site 2 [S2]). MepR binding is impeded in the presence of pentamidine, a MepA substrate. The effects of various mepA operator mutations on MepR binding were determined using electrophoretic mobility shift assays and isothermal titration calorimetry, and an in vivo confirmation of the effects observed was established for a fully palindromic operator mutant. Altering the S1-S2 spacing by 1 to 4 bp severely impaired S2 binding, likely due to a physical collision between adjacent MepR dimers. Extension of the spacing to 9 bp eliminated the S1 binding-mediated DNA allostery required for efficient S2 binding, consistent with positive cooperative binding of MepR dimers. Binding of a single dimer to S1 was maintained when S2 was disrupted, whereas disruption of S1 eliminated any significant binding to S2, also consistent with positive cooperativity. Palindromization of binding sites, especially S2, enhanced MepR affinity for the mepA operator and reduced MepA substrate-mediated MepR induction. As a result, the on-off equilibrium between MepR and its binding sites was shifted toward the on state, resulting in less free MepR being available for interaction with inducing ligand. The selective pressure(s) under which mepA expression is advantageous likely contributed to the accumulation of mutations in the mepA operator, resulting in the current sequence from which MepR is readily induced by MepA substrates.

  18. Composite Replacement Panel Strain Survey - Test Results and Data Analysis

    DTIC Science & Technology

    2005-04-01

    curvature about the aircraft longitudinal axis and slight curvature about the aircraft normal. The Part Number for the demonstrator CRP is CRC-ACS-511b...number of the holes in Panel I were elongated in the transverse direction (vertical direction, perpendicular to aircraft longitudinal axis) during... aircraft longitudinal axis) but would be less effective for transverse and shear loads. Further work is required to verify that hole elongation could

  19. Assessing the need for a new nationally representative household panel survey in the United States

    PubMed Central

    Moffitt, Robert; Schoeni, Robert F.; Brown, Charles; Chase-Lansdale, P. Lindsay; Couper, Mick P.; Diez-Roux, Ana V.; Hurst, Erik; Seltzer, Judith A.

    2015-01-01

    We introduce this special issue on the critical matter of whether the existing household panel surveys in the U.S. are adequate to address the important emerging social science and policy questions of the next few decades. We summarize the conference papers which address this issue in different domains. The papers detail many new and important emerging research questions but also identify key limitations in existing panels in addressing those questions. To address these limitations, we consider the advantages and disadvantages of initiating a new, general-purpose omnibus household panel in the U.S. We also discuss the particular benefits of starting new panels that have specific targeted domains such as child development, population health and health care. We also develop a list of valuable enhancements to existing panels which could address many of their limitations. PMID:26688609

  20. Space weather forecasting with a Multimodel Ensemble Prediction System (MEPS)

    NASA Astrophysics Data System (ADS)

    Schunk, R. W.; Scherliess, L.; Eccles, V.; Gardner, L. C.; Sojka, J. J.; Zhu, L.; Pi, X.; Mannucci, A. J.; Butala, M.; Wilson, B. D.; Komjathy, A.; Wang, C.; Rosen, G.

    2016-07-01

    The goal of the Multimodel Ensemble Prediction System (MEPS) program is to improve space weather specification and forecasting with ensemble modeling. Space weather can have detrimental effects on a variety of civilian and military systems and operations, and many of the applications pertain to the ionosphere and upper atmosphere. Space weather can affect over-the-horizon radars, HF communications, surveying and navigation systems, surveillance, spacecraft charging, power grids, pipelines, and the Federal Aviation Administration (FAA's) Wide Area Augmentation System (WAAS). Because of its importance, numerous space weather forecasting approaches are being pursued, including those involving empirical, physics-based, and data assimilation models. Clearly, if there are sufficient data, the data assimilation modeling approach is expected to be the most reliable, but different data assimilation models can produce different results. Therefore, like the meteorology community, we created a Multimodel Ensemble Prediction System (MEPS) for the Ionosphere-Thermosphere-Electrodynamics (ITE) system that is based on different data assimilation models. The MEPS ensemble is composed of seven physics-based data assimilation models for the ionosphere, ionosphere-plasmasphere, thermosphere, high-latitude ionosphere-electrodynamics, and middle to low latitude ionosphere-electrodynamics. Hence, multiple data assimilation models can be used to describe each region. A selected storm event that was reconstructed with four different data assimilation models covering the middle and low latitude ionosphere is presented and discussed. In addition, the effect of different data types on the reconstructions is shown.

  1. Estimation and adjustment of self-selection bias in volunteer panel web surveys

    NASA Astrophysics Data System (ADS)

    Niu, Chengying

    2016-06-01

    By using propensity score matching method of random sample, we matched simple random sample units and volunteer panel Web survey sample units based on the equal or similar propensity score. The unbiased estimators of the population parameters are constructed by using the matching simple random sample, and the self-selection bias is estimated. We propose propensity score weighted and matching sample post stratification weighted methods to estimate the population parameters, and the self-selection bias in volunteer panel Web Surveys are adjusted.

  2. Panel Conditioning in Longitudinal Studies: Evidence from Labor Force Items in the Current Population Survey

    PubMed Central

    Halpern-Manners, Andrew; Warren, John Robert

    2013-01-01

    Does participating in a longitudinal survey affect respondents’ answers to subsequent questions about their labor force characteristics? In this article, we investigate the magnitude of “panel conditioning” or “time in survey” biases for key labor force questions in the monthly Current Population Survey (CPS). Using linked CPS records for household heads first interviewed between January 2007 and June 2010, our analyses are based on strategic within-person comparisons across survey months and between-person comparisons across CPS rotation groups. We find considerable evidence for panel conditioning effects in the CPS. Panel conditioning downwardly biases the CPS-based unemployment rate, mainly by leading people to remove themselves from its denominator. Across surveys, CPS respondents (claim to) leave the labor force in greater numbers than otherwise equivalent respondents who are participating in the CPS for the first time. The results cannot be attributed to panel attrition or mode effects. We discuss implications for CPS-based research and policy as well as for survey methodology more broadly. PMID:22893185

  3. Poverty and severe psychiatric disorder in the U.S.: evidence from the Medical Expenditure Panel Survey.

    PubMed

    Vick, Brandon; Jones, Kristine; Mitra, Sophie

    2012-06-01

    Previous studies have shown that persons with severe psychiatric disorders are more likely to be poor and face disparities in education and employment outcomes. Poverty rates, the standard measure of poverty, give no information on how far below the poverty line this group falls. This paper compares the poverty rate, poverty depth (distance from the poverty line) and poverty severity (inequality of incomes below the poverty line) of households with and without a working-age member with severe psychiatric disorder in the United States using data from the 2007 Medical Expenditure Panel Survey (MEPS). First, we perform multivariate analysis of the association between severe disorder and poverty depth using MEPS data. Second, we calculate poverty rates, depth, and severity for the subgroup of households having a member with disorder and compare to the subgroup of households without such a member. In multivariate regressions, the presence of a household member with severe psychiatric disorder predicts a 52-percentage point increase in poverty depth and 3.10 times the odds of being poor. Poverty rate, depth, and severity are significantly greater for households of persons with disorder. Mean total incomes are lower for households of persons with severe disorder compared to other households while mean health expenditures are similar. Severe psychiatric disorder is associated with greater depth of poverty and likelihood of being poor. We identify groups who are the most disadvantaged according to severity of income poverty among households with severe psychiatric disorder. These include households whose head has no high school education, who has been without work for the entire year, and who is black or Hispanic. While these characteristics are related to poverty for the overall sample, they correlate to heightened poverty severity when combined with severe disorder. Families face less severity than single persons but poverty rate, depth, and severity increase for both

  4. Changes in the Returns to Schooling 1991-2002: Evidence from the British Household Panel Survey

    ERIC Educational Resources Information Center

    McGuinness, Seamus; Bennett, Jessica

    2009-01-01

    The present paper uses British Household Panel Survey data from 1991 to 2002 to assess the extent to which labour market returns have been influenced by changes in the nature of educational supply. We find that whilst there have been substantial shifts in the returns to schooling over the period, these effects are much more pronounced for younger…

  5. The Percentage of Amplitude Decrease Warning Criteria for Transcranial MEP Monitoring.

    PubMed

    Journée, Henricus L; Berends, Hanneke I; Kruyt, Moyo C

    2017-01-01

    Muscle motor evoked potentials (MEPs) from transcranial electrical stimulation (TES) became a standard technique for monitoring the motor functions of the brain and spinal cord at risk during spinal and brain surgery. However, a wide range of criteria based on the percentage of amplitude decrease is used in practice. A survey of the current literature on clinical outcome parameters reveals a variety of percentages in a range of 30% to 100% (50% to 100% spinal procedures) with no consensus. The interpretation of muscle MEPs is hampered by their sensitivity to many interfering factors. Trial-to-trial MEP variations may partly be reduced by controllable parameters of which TES parameters are in the hands of the neuromonitorist. We propose an operational model based on basic neurophysiologic knowledge to interpret the characteristics of MEP-TES voltage curves and predict the influences of the location on the sigmoid voltage curve on spontaneous MEP-variations and influences of factors affecting the voltage curve. The model predicts a correlation between the slope, expressed by a gain, and variations of muscle MEP amplitudes. This complies with two case examples. The limited specificity/sensitivity of warning criteria based on the percentage of amplitude reduction can possibly be improved by developing standards for set-up procedures of TES paradigms. These procedures include strategies for desensitizing MEPs for variations of controllable parameters. The TES voltage or current is a feasible controlling parameter and should be related to the motor threshold and the onset of the supramaximal level being landmarks of MEP-voltage functions. These parameters may offer a valuable addition to multicenter outcome studies.

  6. Amt/MEP/Rh proteins conduct ammonia.

    PubMed

    Winkler, Fritz K

    2006-03-01

    The structure determination of the ammonium transport protein AmtB from Escherichia coli strongly indicates that the members of the ubiquitous ammonium transporter/methylamine permease/Rhesus (Amt/MEP/Rh) protein family are ammonia-conducting channels rather than ammonium ion transporters. The most conserved part of these proteins, apart from the common overall structure with 11 transmembrane helices, is the pore lined by hydrophobic side chains except for two highly conserved histidine residues. A high-affinity ion-binding site specific for ammonium is present at the extracellular pore entry of the Amt/MEP proteins. It is proposed to play an important role in enhancing net transport at very low external ammonium concentrations and to provide discrimination against water. The site is not conserved in the animal Rhesus proteins which are implicated in ammonium homeostasis and saturate at millimolar ammonium concentrations. Many aspects of the biological function of these ammonia channels are still poorly understood and further studies in cellular systems are needed. Likewise, studies with purified, reconstituted Amt/MEP/Rh proteins will be needed to resolve open mechanistic questions and gain a more quantitative understanding of the conduction mechanism in general and for different subfamily representatives.

  7. Selection of key financial indicators: a literature, panel and survey approach.

    PubMed

    Pink, George H; Daniel, Imtiaz; Hall, Linda McGillis; McKillop, Ian

    2007-01-01

    Since 1998, most hospitals in Ontario have voluntarily participated in one of the largest and most ambitious publicly available performance-reporting initiatives in the world. This article describes the method used to select key financial indicators for inclusion in the report including the literature review, panel and survey approaches that were used. The results for five years of recent data for Ontario hospitals are also presented.

  8. An evaluation of health care expenditures in Crohn's disease using the United States Medical Expenditure Panel Survey from 2003 to 2013.

    PubMed

    Bounthavong, Mark; Li, Meng; Watanabe, Jonathan H

    Previous estimates of the economic burden of Crohn's disease (CD) varied widely from $2.0 to $18.2 billion per year (adjusted to 2015 $US). However, these estimates do not reflect recent changes in pharmaceutical treatment options and guidelines. The goal of this study was to update cost estimates of Crohn's disease based on a representative sample of the US population from the most recent 11 years (2003-2013) of the Medical Expenditure Panel Survey (MEPS). A secondary aim described expenditure trends in respondents with and without Crohn's disease pre-post FDA approvals of new biologics and the American College of Gastroenterology Crohn's disease treatment guidelines. Average annual expenditures (total, prescription, inpatient, and outpatient) were evaluated using a pooled cross-sectional design. Respondent data from the most recent 11 years (2003-2013) of MEPS were analyzed. Two-part generalized linear models with power-link were used to estimate the average annual expenditures per patient adjusted to multiple covariates. Confidence intervals (CI) were estimated using bootstrap methods. Difference-in-differences estimations were performed to compare the changes in health care expenditures pre-post FDA approvals of new biologics and the American College of Gastroenterology Crohn's disease treatment guidelines. The annual aggregate economic burden of CD was $6.3 billion in the US. Respondents with CD had higher total (+$6442; 95% CI: $4864 to $8297), prescription (+$3283; 95% CI: $2289 to $4445), inpatient (+$1764; 95% CI: $748 to $3551), and outpatient (+$1191; 95% CI: $592 to $2160) expenditures compared to respondents without CD. In the difference-in-differences estimation, respondents with CD had significantly higher total (P = 0.001) and prescription (P < 0.001) expenditures compared with respondents without CD. Although inpatient and outpatient expenditures were higher in respondents with CD, they were not statistically significant. Respondents with CD

  9. An Experimental Study Using Opt-in Internet Panel Surveys for Behavioral Health Surveillance

    PubMed Central

    Gotway Crawford, Carol A.; Okoro, Catherine A.; Akcin, Haci M.; Dhingra, Satvinder

    2013-01-01

    Objective To present the design and preliminary results of a pilot study to investigate the use of opt-in Internet panel surveys for behavioral health surveillance. Introduction Today, surveyors in both the private and public sectors are facing considerable challenges with random digit dialed (RDD) landline telephone samples. The population coverage rates for landline telephone surveys are being eroded by wireless-only households, portable telephone numbers, telecommunication barriers (e.g., call forwarding, call blocking and pager connections), technological barriers (call-blocking, busy circuits) and increased refusal rates and privacy concerns. Addressing these issues increasingly drives up the costs associated with dual-frame telephone surveys designed to be representative of the target population as well as hinders their ability to be fully representative of the adult population of each state and territory in the United States. In an effort to continue to meet these challenges head on and assist state and territorial public health professionals in the continued collection of data that are representative of their respective populations, novel approaches to behavioral health surveillance need continued examination. Both private and public sector researchers are evaluating the use of Internet opt-in panels to augment dual-frame RDD survey methods. Compared to dual-frame RDD, opt-in Internet panels offer lower costs, quick data collection and dissemination, and the ability to gather additional data on panelists over time. However, as with dual-frame RDD, this mode has similar challenges with coverage error and non-response. Nevertheless, survey methodologists are moving forward and exploring ways to reduce or eliminate biases between the sample and the target population. Methods A collaborative pilot project was designed to assess the feasibility and accuracy of opt-in Internet panel surveys for behavioral health surveillance. This pilot project is a collaboration

  10. Comparing Twitter and Online Panels for Survey Recruitment of E-Cigarette Users and Smokers

    PubMed Central

    Kim, Annice; Murphy, Joe; Bradfield, Brian; Nonnemaker, James; Hsieh, Yuli

    2016-01-01

    Background E-cigarettes have rapidly increased in popularity in recent years, driven, at least in part, by marketing and word-of-mouth discussion on Twitter. Given the rapid proliferation of e-cigarettes, researchers need timely quantitative data from e-cigarette users and smokers who may see e-cigarettes as a cessation tool. Twitter provides an ideal platform for recruiting e-cigarette users and smokers who use Twitter. Online panels offer a second method of accessing this population, but they have been criticized for recruiting too few young adults, among whom e-cigarette use rates are highest. Objective This study compares effectiveness of recruiting Twitter users who are e-cigarette users and smokers who have never used e-cigarettes via Twitter to online panelists provided by Qualtrics and explores how users recruited differ by demographics, e-cigarette use, and social media use. Methods Participants were adults who had ever used e-cigarettes (n=278; male: 57.6%, 160/278; age: mean 34.26, SD 14.16 years) and smokers (n=102; male: 38.2%, 39/102; age: mean 42.80, SD 14.16 years) with public Twitter profiles. Participants were recruited via online panel (n=190) or promoted tweets using keyword targeting for e-cigarette users (n=190). Predictor variables were demographics (age, gender, education, race/ethnicity), e-cigarette use (eg, past 30-day e-cigarette use, e-cigarette puffs per day), social media use behaviors (eg, Twitter use frequency), and days to final survey completion from survey launch for Twitter versus panel. Recruitment method (Twitter, panel) was the dependent variable. Results Across the total sample, participants were recruited more quickly via Twitter (incidence rate ratio=1.30, P=.02) than panel. Compared with young adult e-cigarette users (age 18-24 years), e-cigarette users aged 25 to 34 years (OR 0.01, 95% CI 0.00-0.60, P=.03) and 35 to 44 years (OR 0.01, 95% CI 0.00-0.51, P=.02) were more likely to be recruited via Twitter than panel

  11. Comparing Twitter and Online Panels for Survey Recruitment of E-Cigarette Users and Smokers.

    PubMed

    Guillory, Jamie; Kim, Annice; Murphy, Joe; Bradfield, Brian; Nonnemaker, James; Hsieh, Yuli

    2016-11-15

    E-cigarettes have rapidly increased in popularity in recent years, driven, at least in part, by marketing and word-of-mouth discussion on Twitter. Given the rapid proliferation of e-cigarettes, researchers need timely quantitative data from e-cigarette users and smokers who may see e-cigarettes as a cessation tool. Twitter provides an ideal platform for recruiting e-cigarette users and smokers who use Twitter. Online panels offer a second method of accessing this population, but they have been criticized for recruiting too few young adults, among whom e-cigarette use rates are highest. This study compares effectiveness of recruiting Twitter users who are e-cigarette users and smokers who have never used e-cigarettes via Twitter to online panelists provided by Qualtrics and explores how users recruited differ by demographics, e-cigarette use, and social media use. Participants were adults who had ever used e-cigarettes (n=278; male: 57.6%, 160/278; age: mean 34.26, SD 14.16 years) and smokers (n=102; male: 38.2%, 39/102; age: mean 42.80, SD 14.16 years) with public Twitter profiles. Participants were recruited via online panel (n=190) or promoted tweets using keyword targeting for e-cigarette users (n=190). Predictor variables were demographics (age, gender, education, race/ethnicity), e-cigarette use (eg, past 30-day e-cigarette use, e-cigarette puffs per day), social media use behaviors (eg, Twitter use frequency), and days to final survey completion from survey launch for Twitter versus panel. Recruitment method (Twitter, panel) was the dependent variable. Across the total sample, participants were recruited more quickly via Twitter (incidence rate ratio=1.30, P=.02) than panel. Compared with young adult e-cigarette users (age 18-24 years), e-cigarette users aged 25 to 34 years (OR 0.01, 95% CI 0.00-0.60, P=.03) and 35 to 44 years (OR 0.01, 95% CI 0.00-0.51, P=.02) were more likely to be recruited via Twitter than panel. Smokers aged 35 to 44 years were less

  12. Updated U.S. population standard for the Veterans RAND 12-item Health Survey (VR-12).

    PubMed

    Selim, Alfredo J; Rogers, William; Fleishman, John A; Qian, Shirley X; Fincke, Benjamin G; Rothendler, James A; Kazis, Lewis E

    2009-02-01

    The purpose of this project was to develop an updated U.S. population standard for the Veterans RAND 12-item Health Survey (VR-12). We used a well-defined and nationally representative sample of the U.S. population from 52,425 responses to the Medical Expenditure Panel Survey (MEPS) collected between 2000 and 2002. We applied modified regression estimates to update the non-proprietary 1990 scoring algorithms. We applied the updated standard to the Medicare Health Outcomes Survey (HOS) to compute the VR-12 physical (PCS((MEPS standard))) and mental (MCS((MEPS standard))) component summaries based on the MEPS. We compared these scores to PCS and MCS based on the 1990 U.S. population standard. Using the updated U.S. population standard, the average VR-12 PCS((MEPS standard)) and MCS((MEPS standard)) scores in the Medicare HOS were 39.82 (standard deviation [SD] = 12.2) and 50.08 (SD = 11.4), respectively. For the same Medicare HOS, the average PCS and MCS scores based on the 1990 standard were 1.40 points higher and 0.99 points lower in comparison to VR-12 PCS and MCS, respectively. Changes in the U.S. population between 1990 and today make the old standard obsolete for the VR-12, so the updated standard developed here is widely available to serve as such a contemporary standard for future applications for health-related quality of life (HRQoL) assessments.

  13. Online and Social Media Data As an Imperfect Continuous Panel Survey

    PubMed Central

    2016-01-01

    There is a large body of research on utilizing online activity as a survey of political opinion to predict real world election outcomes. There is considerably less work, however, on using this data to understand topic-specific interest and opinion amongst the general population and specific demographic subgroups, as currently measured by relatively expensive surveys. Here we investigate this possibility by studying a full census of all Twitter activity during the 2012 election cycle along with the comprehensive search history of a large panel of Internet users during the same period, highlighting the challenges in interpreting online and social media activity as the results of a survey. As noted in existing work, the online population is a non-representative sample of the offline world (e.g., the U.S. voting population). We extend this work to show how demographic skew and user participation is non-stationary and difficult to predict over time. In addition, the nature of user contributions varies substantially around important events. Furthermore, we note subtle problems in mapping what people are sharing or consuming online to specific sentiment or opinion measures around a particular topic. We provide a framework, built around considering this data as an imperfect continuous panel survey, for addressing these issues so that meaningful insight about public interest and opinion can be reliably extracted from online and social media data. PMID:26730933

  14. Online and Social Media Data As an Imperfect Continuous Panel Survey.

    PubMed

    Diaz, Fernando; Gamon, Michael; Hofman, Jake M; Kıcıman, Emre; Rothschild, David

    2016-01-01

    There is a large body of research on utilizing online activity as a survey of political opinion to predict real world election outcomes. There is considerably less work, however, on using this data to understand topic-specific interest and opinion amongst the general population and specific demographic subgroups, as currently measured by relatively expensive surveys. Here we investigate this possibility by studying a full census of all Twitter activity during the 2012 election cycle along with the comprehensive search history of a large panel of Internet users during the same period, highlighting the challenges in interpreting online and social media activity as the results of a survey. As noted in existing work, the online population is a non-representative sample of the offline world (e.g., the U.S. voting population). We extend this work to show how demographic skew and user participation is non-stationary and difficult to predict over time. In addition, the nature of user contributions varies substantially around important events. Furthermore, we note subtle problems in mapping what people are sharing or consuming online to specific sentiment or opinion measures around a particular topic. We provide a framework, built around considering this data as an imperfect continuous panel survey, for addressing these issues so that meaningful insight about public interest and opinion can be reliably extracted from online and social media data.

  15. Correlation Results for a Mass Loaded Vehicle Panel Test Article Finite Element Models and Modal Survey Tests

    NASA Technical Reports Server (NTRS)

    Maasha, Rumaasha; Towner, Robert L.

    2012-01-01

    High-fidelity Finite Element Models (FEMs) were developed to support a recent test program at Marshall Space Flight Center (MSFC). The FEMs correspond to test articles used for a series of acoustic tests. Modal survey tests were used to validate the FEMs for five acoustic tests (a bare panel and four different mass-loaded panel configurations). An additional modal survey test was performed on the empty test fixture (orthogrid panel mounting fixture, between the reverb and anechoic chambers). Modal survey tests were used to test-validate the dynamic characteristics of FEMs used for acoustic test excitation. Modal survey testing and subsequent model correlation has validated the natural frequencies and mode shapes of the FEMs. The modal survey test results provide a basis for the analysis models used for acoustic loading response test and analysis comparisons

  16. A flexible model for correlated medical costs, with application to medical expenditure panel survey data.

    PubMed

    Chen, Jinsong; Liu, Lei; Shih, Ya-Chen T; Zhang, Daowen; Severini, Thomas A

    2016-03-15

    We propose a flexible model for correlated medical cost data with several appealing features. First, the mean function is partially linear. Second, the distributional form for the response is not specified. Third, the covariance structure of correlated medical costs has a semiparametric form. We use extended generalized estimating equations to simultaneously estimate all parameters of interest. B-splines are used to estimate unknown functions, and a modification to Akaike information criterion is proposed for selecting knots in spline bases. We apply the model to correlated medical costs in the Medical Expenditure Panel Survey dataset. Simulation studies are conducted to assess the performance of our method.

  17. Dry eye medication use and expenditures: data from the medical expenditure panel survey 2001 to 2006.

    PubMed

    Galor, Anat; Zheng, D Diane; Arheart, Kristopher L; Lam, Byron L; Perez, Victor L; McCollister, Kathryn E; Ocasio, Manuel; McClure, Laura A; Lee, David J

    2012-12-01

    To study dry eye medication use and expenditures from 2001 to 2006 using a nationally representative sample of US adults. This study retrospectively analyzed dry eye medication use and expenditures of participants of the 2001 to 2006 Medical Expenditure Panel Survey, a nationally representative subsample of the National Health Interview Survey. After adjusting for survey design and for inflation using the 2009 inflation index, data from 147 unique participants aged 18 years or older using the prescription medications Restasis and Blephamide were analyzed. The main outcome measures were dry eye medication use and expenditures from 2001 to 2006. Dry eye medication use and expenditures increased between the years 2001 and 2006, with the mean expenditure per patient per year being $55 in 2001 to 2002 (n=29), $137 in 2003 to 2004 (n=32), and $299 in 2005 to 2006 (n=86). This finding was strongly driven by the introduction of topical cyclosporine emulsion 0.05% (Restasis; Allergan, Irvine, CA). In analysis pooled over all survey years, demographic factors associated with dry eye medication expenditures included gender (female: $244 vs. male: $122, P<0.0001), ethnicity (non-Hispanic: $228 vs. Hispanic: $106, P<0.0001), and education (greater than high school: $250 vs. less than high school: $100, P<0.0001). We found a pattern of increasing dry eye medication use and expenditures from 2001 to 2006. Predictors of higher dry eye medication expenditures included female gender, non-Hispanic ethnicity, and greater than a high school education.

  18. Data collecting activities of the 'Outlook for Space' Panel. [information sources for technological forecasting survey

    NASA Technical Reports Server (NTRS)

    Stroud, W. G.

    1977-01-01

    The paper describes the work of the 'Outlook for Space' Panel, a NASA-wide study group concerned with the role space flight might play in American society during the years approaching 2000. The study considers the progression of projects from 'could do' (for which capability exists), to 'should do' (because of social benefits), to 'will do' (unknown at this time). Opinions as to objectives were solicited from NASA personnel, advisory committees, industrial organizations, and academic theoreticians. Poll data was examined. A large-scale survey of the attitudes of young people toward the future and space was also undertaken, and a complete matrix is presented of themes (such as production and management of food and forestry resources) and theme subcategory specific activities (for example, global crop production), versus the students' perceived areas of national interest or benefit (e.g., expansion of human knowledge).

  19. Employment and Disability: Evidence From the 1996 Medical Expenditures Panel Survey

    PubMed Central

    Findley, Patricia A.; Sambamoorthi, Usha

    2007-01-01

    The relationship between employment and disability has gained national attention, as the ability to maintain employment is inconsistent among those with limitations. This cross-sectional study of employment among individuals (N = 1691, age 21–62 years) with self-reported limitations in the 1996 Medical Expenditures Panel Survey seeks to identify predictors of employment despite physical and/or cognitive limitations. Two predictive models of employment including 10 variables are explored; 1 included insurance (χ2 = 3856.85, p ≤ 0.00) and the other removed the insurance variable (χ2 = 280.21, p ≤ 0.00). Individuals with limitations who are employed are more likely to have a college-level education, have better physical and mental health perceptions and have private insurance. This analysis demonstrates that people do work despite reported activity, functional or sensory limitations and that socioeconomic factors are crucial in why someone is able to attain employment. PMID:15055500

  20. Data collecting activities of the 'Outlook for Space' Panel. [information sources for technological forecasting survey

    NASA Technical Reports Server (NTRS)

    Stroud, W. G.

    1977-01-01

    The paper describes the work of the 'Outlook for Space' Panel, a NASA-wide study group concerned with the role space flight might play in American society during the years approaching 2000. The study considers the progression of projects from 'could do' (for which capability exists), to 'should do' (because of social benefits), to 'will do' (unknown at this time). Opinions as to objectives were solicited from NASA personnel, advisory committees, industrial organizations, and academic theoreticians. Poll data was examined. A large-scale survey of the attitudes of young people toward the future and space was also undertaken, and a complete matrix is presented of themes (such as production and management of food and forestry resources) and theme subcategory specific activities (for example, global crop production), versus the students' perceived areas of national interest or benefit (e.g., expansion of human knowledge).

  1. The role of general practitioners in medical school admission interview panels in the UK (2012-2014): a national survey.

    PubMed

    Rashid, Mohammed Ahmed; Benson, John

    2016-07-01

    Recent primary care workforce pressures in the UK have prompted national reviews. Recommendations to increase the proportion of medical students entering general practice have led to interest in the role of medical schools in career choices. This study sought to identify the career backgrounds of admissions leads at UK medical schools and the proportion of general practitioners on admission interview panels. A national survey using a proforma circulated to all UK medical school admission leads via the Medical Schools Council. UK medical schools. UK medical schools. Prevalence of assessment lead and panel members' professional groups. Responses were received from 18 (54.5%) of the 33 UK medical schools. General practitioners led the admissions process in 2 (11%) of these. Fifteen schools were able to furnish detailed data about interview panel composition, having held a combined total of 876 distinct interview panels during the 2012-2013 and 2013-2014 admission years; 683 panels (78%) included a secondary care physician, but only 261 panels (29.8%) included general practitioners. General practitioner representation ranged from 3.8% to 100% of individual schools' panels; however, eight schools (about half the respondents able to offer numbers of participants) omitted general practitioner representation in more than half of their interview panels. Despite the UK policy focus to increase the proportion of medical students becoming general practitioners, doctors from this clinical background are not proportionately represented as admissions leads or on admissions interview panels. Increasing general practitioner involvement in admissions processes may be one way in which medical schools can support general practice as a career aspiration.

  2. Dynamics of Adult Participation in Part-Time Education and Training: Results from the British Household Panel Survey

    ERIC Educational Resources Information Center

    Macleod, Flora; Lambe, Paul

    2008-01-01

    In this paper we analyse the dynamics of adult participation in part-time education and training throughout the 90s and into the 2000s using data from 14 waves (1992-2005) of the British Household Panel Survey (BHPS). We study the volume (stocks) of participation and non-participation and the gross flows between states. This analysis provides a…

  3. Dynamics of Adult Participation in Part-Time Education and Training: Results from the British Household Panel Survey

    ERIC Educational Resources Information Center

    Macleod, Flora; Lambe, Paul

    2008-01-01

    In this paper we analyse the dynamics of adult participation in part-time education and training throughout the 90s and into the 2000s using data from 14 waves (1992-2005) of the British Household Panel Survey (BHPS). We study the volume (stocks) of participation and non-participation and the gross flows between states. This analysis provides a…

  4. Distinguishing the Influences of Father's and Mother's Involvement on Adolescent Academic Achievement: Analyses of Taiwan Education Panel Survey Data

    ERIC Educational Resources Information Center

    Hsu, Hsien-Yuan; Zhang, Dalun; Kwok, Oi-Man; Li, Yan; Ju, Song

    2011-01-01

    Using a sample drawn from Taiwan, this study evaluated the role of mother and father involvement in adolescent academic achievement. The participants were drawn from the Taiwan Education Panel Survey (TEPS) and consisted of 8,108 adolescents who studied seventh grade in 2001. Father and mother involvement related to academic achievement was…

  5. Radiation dose survey in a paediatric cardiac catheterisation laboratory equipped with flat-panel detectors.

    PubMed

    Dragusin, O; Gewillig, M; Desmet, W; Smans, K; Struelens, L; Bosmans, H

    2008-01-01

    Flat-panel X-ray detectors for fluoroscopy represent a modern imaging equipment that is being implemented in paediatric cardiac catheterisation laboratories. Infants and children represent a group of patients with a high radiosensitivity. A survey of 273 (126 diagnostic and 147 therapeutic) paediatric catheterisations was performed to investigate the radiation doses delivered by the new X-ray system. Statistical parameters (75th, 50th and 25th percentiles) of dose-area product (DAP) and fluoroscopy time are reported for patients divided into six age groups: 0-30 d, >1-12 m, >1-3, >3-5, >5-10 and >10-15 y. For accurate risk estimation, effective dose (E) has been determined for all patients using the PCXMC software. For diagnostic procedures, the third quartile of E ranges from 11.3 mSv for newborns to 7 mSv for children of 10-15 y. Therapeutic procedures are more complex than diagnostic. Consequently, the third quartile of E is 22.6 mSv (0-30 d), 18.6 (>1-12 m), 13.3 (>1-3 y), 21.5 (>3-5 y), 17.8 (>5-10 y) and 34.1 mSv (>10-15 y). Dose conversion factors, which relate the DAP and E, have been estimated for each age group. The results of this study may serve as a first step in the optimisation process, in order to make full use of the dose reduction potential of flat-panel systems.

  6. Trends of medical expenditures and quality of life in US adults with diabetes: the medical expenditure panel survey, 2002-2011.

    PubMed

    Campbell, Jennifer A; Bishu, Kinfe G; Walker, Rebekah J; Egede, Leonard E

    2017-04-13

    Studies indicate a relationship between cost and quality of life (QOL) in diabetes care, however, the interaction is complex and the relationship is not well understood. The aim of this study was to 1) examine the relationship of quartiles of QOL on cost amongst U.S. adults with diabetes, 2) investigate how the relationship may change over time, and 3) examine the incremental effect of QOL on cost while controlling for other relevant covariates. Data from 2002-2011 Medical Expenditure Panel Survey (MEPS) was used to examine the association between QOL and medical expenditures among adults with diabetes (aged ≥18 years) N = 20,442. Unadjusted means were computed to compare total healthcare expenditure and the out-of-pocket expenses by QOL quartile categories. QOL measures were Physical Component Summary (PCS) and Mental Component Summary (MCS) derived from the Short-Form 12. A two-part model was then used to estimate adjusted incremental total healthcare expenditure and out-of-pocket expenses adjusting for relevant covariates. Differences between the highest and lowest quartiles totaled $11,801 for total expenditures and $989 for out-of-pocket expenses. Over time, total expenditures remained stable, while out-of-pocket expenses decreased, particularly for the lowest quartile of physical component of QOL. Similar trends were seen in the mental component, however, differences between quartiles were smaller (average $5,727 in total expenses; $287 in out-of-pocket). After adjusting for covariates, those in the highest quartile of physical component of QOL spent $7,500 less, and those in the highest quartile of mental component spent $3,000 less than those in the lowest quartiles. A clear gradient between QOL and cost with increasing physical and mental QOL associated with lower expenditures and out-of-pocket expenses was found. Over a 10-year time period those with the highest physical QOL had significantly less medical expenditures compared to those with the

  7. Community Decadal Panel for Mars: Initial Considerations

    NASA Astrophysics Data System (ADS)

    Moore, J. M.; Barlow, N.; Bogard, D.; Clark, R.; Clifford, S.; Haldemann, A.; Leshin, L.; Shearer, C.; Treiman, A.; Weiss, B.; Wilson, J.

    2001-11-01

    The exploration of Mars is currently the centerpiece of NASA planetary research. This has been, in recent times, driven by the possibility that this world once was more Earth-like in some ways that it is today, and hence may hold evidence for the origin and diversity of life in the universe. Life in the universe is currently the overarching theme in NASA space science endeavors. Thus Mars in the upcoming decade is currently planned to figure largely in planetary missions and research and so is inevitably a major topic of decadal planning activity. We, the Mars Community Decadal Panel, are reviewing all aspects of high level Mars strategy. We are considering and potentially reaffirming the desirability of a separate, parallel Mars program (as it is currently compartmentalized within NASA). We are addressing the tempo and goals of the sample-return-directed "Mars Exploration Program" (MEP), including a review of the new mission road map (as driven by prioritized science). We will review the importance of the Scout program relative to the MEP (For instance, should some resources nominally earmarked for MEP be reallocated in order to keep the Scout program healthy?). We are looking for synergy with science at other targets. In other words, what non-Mars planetary science missions most benefit our understanding of Mars? Bearing in mind that the Academy of Sciences Decadal Survey report will order Solar-System-wide science priorities, and that its tone will be that of community consensus, it is in our purview to consider where Mars fits into this overall plan for Solar System exploration.

  8. Estimating population food and nutrient exposure: a comparison of store survey data with household panel food purchases.

    PubMed

    Eyles, Helen; Neal, Bruce; Jiang, Yannan; Ni Mhurchu, Cliona

    2016-05-28

    Population exposure to food and nutrients can be estimated from household food purchases, but store surveys of foods and their composition are more available, less costly and might provide similar information. Our aim was to compare estimates of nutrient exposure from a store survey of packaged food with those from household panel food purchases. A cross-sectional store survey of all packaged foods for sale in two major supermarkets was undertaken in Auckland, New Zealand, between February and May 2012. Longitudinal household food purchase data (November 2011 to October 2012) were obtained from the nationally representative, population-weighted New Zealand Nielsen HomeScan® panel. Data on 8440 packaged food and non-alcoholic beverage products were collected in the store survey. Food purchase data were available for 1229 households and 16 812 products. Store survey data alone produced higher estimates of exposure to Na and sugar compared with estimates from household panel food purchases. The estimated mean difference in exposure to Na was 94 (95 % CI 72, 115) mg/100 g (20 % relative difference; P<0·01), to sugar 1·6 (95 % CI 0·8, 2·5) g/100 g (11 %; P<0·01), to SFA -0·3 (95 % CI -0·8, 0·3) g/100 g (6 %; P=0·3) and to energy -18 (-71, 35) kJ/100 g (2 %; P=0·51). Compared with household panel food purchases, store survey data provided a reasonable estimate of average population exposure to key nutrients from packaged foods. However, caution should be exercised in using such data to estimate population exposure to Na and sugar and in generalising these findings to other countries, as well as over time.

  9. Widows' land security in the era of HIV/AIDS: panel survey evidence from Zambia.

    PubMed

    Chapoto, Antony; Jayne, T S; Mason, Nicole M

    2011-01-01

    In areas of Africa hard hit by HIV/AIDS, there are growing concerns that many women lose access to land after the death of their husbands. However, there remains a dearth of quantitative evidence on the proportion of widows who lose access to their deceased husband's land, whether they lose all or part of that land, and whether there are factors specific to the widow, her family, or the broader community that influence her ability to maintain rights to land. This study examines these issues using average treatment effects models with propensity score matching applied to a nationally representative panel data of 5,342 rural households surveyed in 2001 and 2004. Results are highly variable, with roughly a third of households incurring the death of a male household head controlling less than 50% of the land they had prior to their husband's death, while over a quarter actually controlled as much or even more land than while their husbands were alive. Widows who were in relatively wealthy households prior to their husband's death lose proportionately more land than widows in households that were relatively poor. Older widows and widows related to the local headman enjoy greater land security. Women in matrilineal inheritance areas were no less likely to lose land than women in patrilineal areas.

  10. Employment transitions and mental health: an analysis from the British household panel survey

    PubMed Central

    Thomas, C.; Benzeval, M.; Stansfeld, S.

    2005-01-01

    Study objective: To describe the impact of changes between employment and various forms of non-employment, and vice versa, on the psychological wellbeing of men and of women. Design: Separate multivariate models for men and for women were constructed to study the association between employment transitions and episodes of psychological distress (general health questionnaire). Participants: 13 359 employment transitions from 5092 people aged 16–74 years in the British household panel survey from 1991 to 1998. Main results: Transitions from paid employment to either unemployment or long term sick leave were associated with increased psychological distress for both men and women. Starting maternity leave or staying home to look after the family were also associated with psychological distress for women. Transitions from these roles to formal employment resulted in an improvement in mental health. There was some evidence that the effects were felt most strongly within six months of the transition. Conclusions: This paper provides further evidence that movements between paid employment and various forms of non-employment, in addition to unemployment, have an impact on mental health. The emphasis on transitions between a full range of employment states for both men and women from a large population based longitudinal study and a comparison of the relative magnitude of effects are unique features of this analysis. Interventions are suggested to minimise the psychological distress associated with transitions. PMID:15709086

  11. Cross-Sectional and Panel Data Analyses of an Incompletely Observed Variable Derived from the Nonrandomized Method for Surveying Sensitive Questions

    ERIC Educational Resources Information Center

    Yamaguchi, Kazuo

    2016-01-01

    This article describes (1) the survey methodological and statistical characteristics of the nonrandomized method for surveying sensitive questions for both cross-sectional and panel survey data and (2) the way to use the incompletely observed variable obtained from this survey method in logistic regression and in loglinear and log-multiplicative…

  12. Structural basis for Mep2 ammonium transceptor activation by phosphorylation

    PubMed Central

    van den Berg, Bert; Chembath, Anupama; Jefferies, Damien; Basle, Arnaud; Khalid, Syma; Rutherford, Julian C.

    2016-01-01

    Mep2 proteins are fungal transceptors that play an important role as ammonium sensors in fungal development. Mep2 activity is tightly regulated by phosphorylation, but how this is achieved at the molecular level is not clear. Here we report X-ray crystal structures of the Mep2 orthologues from Saccharomyces cerevisiae and Candida albicans and show that under nitrogen-sufficient conditions the transporters are not phosphorylated and present in closed, inactive conformations. Relative to the open bacterial ammonium transporters, non-phosphorylated Mep2 exhibits shifts in cytoplasmic loops and the C-terminal region (CTR) to occlude the cytoplasmic exit of the channel and to interact with His2 of the twin-His motif. The phosphorylation site in the CTR is solvent accessible and located in a negatively charged pocket ∼30 Å away from the channel exit. The crystal structure of phosphorylation-mimicking Mep2 variants from C. albicans show large conformational changes in a conserved and functionally important region of the CTR. The results allow us to propose a model for regulation of eukaryotic ammonium transport by phosphorylation. PMID:27088325

  13. Family Formation Processes: Assessing the Need for a New Nationally Representative Household Panel Survey in the United States

    PubMed Central

    Manning, Wendy D.

    2015-01-01

    The American family has undergone rapid transformation. Careful measurement attention to family formation is important because families are at the heart of numerous decisions, roles, and responsibilities with implications for understanding the well-being of families, adults and children. This paper considers whether there is a need for a new household panel study that addresses family formation. This paper consists of a review of the recent body of population-based, American surveys and finds a considerable gap in the ability to study the implications of families for the health and well-being of Americans. Earlier panel surveys used to assess family life anchored questions around marital events, but changes in family patterns require attention to a more diverse set of family forms. The paper concludes with recommendations for a multi-purpose panel study. The key challenge is to keep to pace with complexity and changes in American family life while at the same time maintaining a parsimonious set of survey questions. PMID:26612969

  14. Estimating and preventing hospital internal turnover of newly licensed nurses: A panel survey.

    PubMed

    Kovner, Christine T; Djukic, Maja; Fatehi, Faridaben K; Fletcher, Jason; Jun, Jin; Brewer, Carol; Chacko, Thomas

    2016-08-01

    Registered nurse job turnover is an ongoing problem in the USA resulting in significant financial costs to both organizations and society. Most research has focused on organizational turnover with few studies about internal or unit-level turnover. Turnover of new nurses in hospitals has particular importance as almost 80% of new nurses work in hospitals and have higher turnover rates when compared to experienced nurses. This paper focuses on new nurses' unit-level turnover rates in hospitals. The purpose of this study is to: (1) identify factors that predict new nurses staying in the same units, positions, and job titles to inform unit-level retention strategies, and (2) examine the changes in work environment perceptions over time between nurses who remain in the same unit, position, and title to those who changed unit, position and/or title. A panel survey design was used to analyze changes over time. Participants were newly licensed registered nurses who were licensed for the first time between August 1st, 2004 and July 31st, 2005. The nurses came from metropolitan statistical areas or rural areas that were nested to reflect a nationally representative USA sample (58% response rate). The analytic sample for this study was 1335. Data were collected in January 2006 and 2007 following the Dillman total design approach. All potential respondents received paper surveys and non-responders received repeated mailings. Using multinomial regression the five variables with the largest effects on unit retention were (1) variety (positive), (2) having another job for pay (negative), (3) first basic degree (having a bachelors or higher degree increased the probability of staying), (4) negative affectivity (positive), and (5) job satisfaction (positive). Nurses who changed unit, and/or position, and/or title reported more positive change scores on a variety of work attitudes. Almost 30% of new nurses working in hospitals leave their unit, and/or position, and/or title during

  15. A Feasibility Study on Using an Internet-Panel Survey to Measure Perceptions of E-cigarettes in 3 Metropolitan Areas, 2015.

    PubMed

    Miller, Eric A; Berman, Lewis; Atienza, Audie; Middleton, Deirdre; Iachan, Ronaldo; Tortora, Robert; Boyle, John

    Internet-panel surveys are emerging as a means to quickly and cost-effectively collect health data, and because of their large memberships, they could be used for community-level surveys. To determine the feasibility of using an internet-panel survey to quickly provide community-level data, we conducted a pilot test of a health survey in 3 US metropolitan areas. We conducted internet-panel surveys in Cleveland, Ohio; New York, New York; and Seattle, Washington, in 2015. Slightly more than 500 people responded to the survey in each city. We compared weighted unadjusted prevalence estimates from the internet-panel data with estimates from the 2014 Health Information National Trends Survey (HINTS) for the following question in each survey: "Compared to smoking cigarettes, would you say that electronic cigarettes are…much less harmful, less harmful, just as harmful, more harmful, much more harmful, or I've never heard of electronic cigarettes." We used multivariable logistic regression to compare associations of respondents' demographic and health characteristics with perceived harm from e-cigarettes. The prevalence of the perception that e-cigarettes are less harmful than smoking cigarettes ranged from 35.9% to 39.9% in the internet-panel sites and was 43.0% in HINTS. Most patterns of beliefs and respondent characteristics in the internet-panel data were consistent with patterns in HINTS. We found inconsistent patterns between internet-panel sites and HINTS by race/ethnicity and education. This feasibility study found that internet-panel surveys could quickly produce community-level data for targeted public health interventions and evaluation, but they may be limited in producing estimates among subgroups.

  16. Comparison of Australian and US Cost-Benefit Approaches to MEPS

    SciTech Connect

    McMahon, James E.

    2004-03-12

    similar; no changes are recommended. (2) The Australian approach to determining the relationship of price to energy efficiency is based on current market, while the US approach uses prospective estimates. Both approaches may benefit from increased retrospective analysis of impacts of MEPS on appliance and equipment prices. Under some circumstances, Australia may wish to consider analyzing two separate components leading to price impacts: (a) changes in manufacturing costs and (b) markups used to convert from manufacturing costs to consumer price. (3) The Life-Cycle Cost methods are similar, but the USA has statistical surveys that permit a more detailed analysis. Australia uses average values, while the US uses full distributions. If data and resources permit, Australia may benefit from greater depth here as well. If implemented, the changes will provide more information about the benefits and costs of the program, in particular identifying who benefits and who bears net costs so that programs can be designed to offset unintended negative consequences, and may assist the government in convincing affected parties of the justification for some MEPS. However, without a detailed and statistically representative national survey, such an approach may not be practical for Australia at this time. (4) The National Benefits and Costs methods are similar prospective estimates of shipments, costs and energy savings, as well as greenhouse gas emissions. Additional sensitivity studies could further illustrate the ranges in these estimates. Consideration of lower discount rates could lead to more stringent MEPS in some cases. (5) Both the Australian and US analyses of impacts on industry, competition, and trade ultimately depend upon sufficient consultation with industry experts. While the Australian analysis of financial impacts on manufacturers is less detailed than that of the US, the Australian treatment of impacts on market shares imported from different regions of the world is

  17. Development of Antibacterials Targeting the MEP Pathway of Select Agents

    DTIC Science & Technology

    2014-05-01

    1 AD_________________ Award Number: W81XWH-12-2-0014 TITLE: Development of Antibacterials ...COVERED 10 February 2013 - 9 February 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Development of Antibacterials Targeting the MEP Pathway of...targeted for inhibitor development. This pathway is utilized by bacteria, apicomplexan protozoa, and plants for isoprenoid biosynthesis. Isoprenic

  18. EVA 2 activity on Flight Day 5 to survey the HST solar array panels

    NASA Image and Video Library

    1997-02-15

    STS082-719-002 (14 Feb. 1997) --- Astronaut Joseph R. Tanner (right) stands on the end of Discovery's Remote Manipulator System (RMS) arm and aims a camera at the solar array panels on the Hubble Space Telescope (HST) as astronaut Gregory J. Harbaugh assists. The second Extravehicular Activity (EVA) photograph was taken with a 70mm camera from inside Discovery's cabin.

  19. Long-running German panel survey shows that personal and economic choices, not just genes, matter for happiness

    PubMed Central

    Headey, Bruce; Muffels, Ruud; Wagner, Gert G.

    2010-01-01

    Psychologists and economists take contradictory approaches to research on what psychologists call happiness or subjective well-being, and economists call subjective utility. A direct test of the most widely accepted psychological theory, set-point theory, shows it to be flawed. Results are then given, using the economists’ newer “choice approach”—an approach also favored by positive psychologists—which yields substantial payoffs in explaining long-term changes in happiness. Data come from the German Socio-Economic Panel (1984–2008), a unique 25-y prospective longitudinal survey. This dataset enables direct tests of theories explaining long-term happiness. PMID:20921399

  20. Long-running German panel survey shows that personal and economic choices, not just genes, matter for happiness.

    PubMed

    Headey, Bruce; Muffels, Ruud; Wagner, Gert G

    2010-10-19

    Psychologists and economists take contradictory approaches to research on what psychologists call happiness or subjective well-being, and economists call subjective utility. A direct test of the most widely accepted psychological theory, set-point theory, shows it to be flawed. Results are then given, using the economists' newer "choice approach"--an approach also favored by positive psychologists--which yields substantial payoffs in explaining long-term changes in happiness. Data come from the German Socio-Economic Panel (1984-2008), a unique 25-y prospective longitudinal survey. This dataset enables direct tests of theories explaining long-term happiness.

  1. Occupational Choice, Socio-Economic Status and Educational Attainment: A Study of the Occupational Choices and Destinations of Young People in the British Household Panel Survey

    ERIC Educational Resources Information Center

    Croll, Paul

    2008-01-01

    The article considers young people's occupational choices at the age of 15 in relation to their educational attainment, the occupations of their parents and their actual occupations when they are in their early 20s. It uses data from the British Household Panel Survey over periods of between five and ten years. The young people in the survey are…

  2. Attrition Bias in Panel Data: A Sheep in Wolf's Clothing? A Case Study Based on the Mabel Survey.

    PubMed

    Cheng, Terence C; Trivedi, Pravin K

    2015-09-01

    This paper investigates the nature and consequences of sample attrition in a unique longitudinal survey of medical doctors. We describe the patterns of non-response and examine if attrition affects the econometric analysis of medical labour market outcomes using the estimation of physician earnings equations as a case study. We compare the econometric gestimates obtained from a number of different modelling strategies, which are as follows: balanced versus unbalanced samples; an attrition model for panel data based on the classic sample selection model; and a recently developed copula-based selection model. Descriptive evidence shows that doctors who work longer hours, have lower years of experience, are overseas trained and have changed their work location are more likely to drop out. Our analysis suggests that the impact of attrition on inference about the earnings of general practitioners is small. For specialists, there appears to be some evidence for an economically significant bias. Finally, we discuss how the top-up samples in the Medicine in Australia: Balancing Employment and Life survey can be used to address the problem of panel attrition.

  3. The comparison of road safety survey answers between web-panel and face-to-face; Dutch results of SARTRE-4 survey.

    PubMed

    Goldenbeld, C; de Craen, S

    2013-09-01

    In the Netherlands, a comparison of an online and a face-to-face sample of car drivers was made to study differences on a number of selected questions from the SARTRE-4 road safety survey. Contrary to expectations, there was no indication that online respondents were more likely to come from higher educated or more privileged social groups. Confirming earlier research, the results indicated that online respondents were less inclined to give socially desirable answers and were less inclined to use more extreme ratings in their opinions about measures. Contrary to expectations, face-to-face respondents did not tend to give more positive answers in judgment of road safety measures. Weighting to make samples comparable on gender, age, and education had almost no effect on outcomes. The implications for a transition from face-to-face survey to online panel method are discussed. Copyright © 2013 National Safety Council and Elsevier Ltd. All rights reserved.

  4. Disparities in the Reporting and Treatment of Health Conditions in Children: An Analysis of the Medical Expenditure Panel Survey

    PubMed Central

    Guevara, James P; Mandell, David S; Rostain, Anthony L; Zhao, Huaqing; Hadley, Trevor R

    2006-01-01

    Objectives To determine whether racial and ethnic disparities in health care use differ for physical and behavioral health conditions. Data Sources Secondary analysis of the 1996–1997 Medical Expenditure Panel Survey. Study Design Retrospective cohort study of children aged 2–18 years old who were members of participating households. Children were categorized as Hispanic, black, or white. Differences in caregiver-reported behavioral and physical health conditions and services use were compared, and estimates were weighted to reflect the complex sampling scheme. Principal Findings Of eligible children weighted to represent over 44 million in each year, 13–15 percent were Hispanic, 14 percent black, and 68–70 percent white. After adjusting for potential confounding, Hispanic and black children were less likely to report externalizing behavioral conditions than white children. Black but not Hispanic children were more likely than white children to report asthma. In addition, Hispanic and black children were less likely to report ambulatory visits, and black children were less likely to report receiving a prescription medication than white children. There were no differences in reported emergency room visits or hospitalizations. Interactions between race and various health conditions, health status, insurance, and income were not significant. Conclusions In this nationally representative sample, we identified racial and ethnic disparities in the reporting of health conditions and the use of discretionary health services. Disparities differed between those with behavioral conditions and those with physical conditions. These disparities were not explained by traditional measures including the presence of health conditions, health status, insurance, and family income, and suggest that national surveys such as Medical Expenditure Panel Survey may benefit from the inclusion of additional explanatory measures. PMID:16584463

  5. Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design.

    PubMed

    Rübsamen, Nicole; Akmatov, Manas K; Castell, Stefanie; Karch, André; Mikolajczyk, Rafael T

    2017-01-01

    Increasing availability of the Internet allows using only online data collection for more epidemiological studies. We compare response patterns in a population-based health survey using two survey designs: mixed-mode (choice between paper-and-pencil and online questionnaires) and online-only design (without choice). We used data from a longitudinal panel, the Hygiene and Behaviour Infectious Diseases Study (HaBIDS), conducted in 2014/2015 in four regions in Lower Saxony, Germany. Individuals were recruited using address-based probability sampling. In two regions, individuals could choose between paper-and-pencil and online questionnaires. In the other two regions, individuals were offered online-only participation. We compared sociodemographic characteristics of respondents who filled in all panel questionnaires between the mixed-mode group (n = 1110) and the online-only group (n = 482). Using 134 items, we performed multinomial logistic regression to compare responses between survey designs in terms of type (missing, "do not know" or valid response) and ordinal regression to compare responses in terms of content. We applied the false discovery rates (FDR) to control for multiple testing and investigated effects of adjusting for sociodemographic characteristic. For validation of the differential response patterns between mixed-mode and online-only, we compared the response patterns between paper and online mode among the respondents in the mixed-mode group in one region (n = 786). Respondents in the online-only group were older than those in the mixed-mode group, but both groups did not differ regarding sex or education. Type of response did not differ between the online-only and the mixed-mode group. Survey design was associated with different content of response in 18 of the 134 investigated items; which decreased to 11 after adjusting for sociodemographic variables. In the validation within the mixed-mode, only two of those were among the 11 significantly

  6. Malaria Incidence Rates from Time Series of 2-Wave Panel Surveys

    PubMed Central

    Maheu-Giroux, Mathieu; Chiyaka, Christinah; Singer, Burton H.

    2016-01-01

    Methodology to estimate malaria incidence rates from a commonly occurring form of interval-censored longitudinal parasitological data—specifically, 2-wave panel data—was first proposed 40 years ago based on the theory of continuous-time homogeneous Markov Chains. Assumptions of the methodology were suitable for settings with high malaria transmission in the absence of control measures, but are violated in areas experiencing fast decline or that have achieved very low transmission. No further developments that can accommodate such violations have been put forth since then. We extend previous work and propose a new methodology to estimate malaria incidence rates from 2-wave panel data, utilizing the class of 2-component mixtures of continuous-time Markov chains, representing two sub-populations with distinct behavior/attitude towards malaria prevention and treatment. Model identification, or even partial identification, requires context-specific a priori constraints on parameters. The method can be applied to scenarios of any transmission intensity. We provide an application utilizing data from Dar es Salaam, an area that experienced steady decline in malaria over almost five years after a larviciding intervention. We conducted sensitivity analysis to account for possible sampling variation in input data and model assumptions/parameters, and we considered differences in estimates due to submicroscopic infections. Results showed that, assuming defensible a priori constraints on model parameters, most of the uncertainty in the estimated incidence rates was due to sampling variation, not to partial identifiability of the mixture model for the case at hand. Differences between microscopy- and PCR-based rates depend on the transmission intensity. Leveraging on a method to estimate incidence rates from 2-wave panel data under any transmission intensity, and from the increasing availability of such data, there is an opportunity to foster further methodological

  7. Health Insurance Dynamics: Methodological Considerations and a Comparison of Estimates from Two Surveys.

    PubMed

    Graves, John A; Mishra, Pranita

    2016-10-01

    To highlight key methodological issues in studying insurance dynamics and to compare estimates across two commonly used surveys. Nonelderly uninsured adults and children sampled between 2001 and 2011 in the Medical Expenditure Panel Survey and the Survey of Income and Program Participation. We utilized nonparametric Kaplan-Meier methods to estimate quantiles (25th, 50th, and 75th percentiles) in the distribution of uninsured spells. We compared estimates obtained across surveys and across different methodological approaches to address issues like attrition, seam bias, censoring and truncation, and survey weighting method. All data were drawn from publicly available household surveys. Estimated uninsured spell durations in the MEPS were longer than those observed in the SIPP. There were few changes in spell durations between 2001 and 2011, with median durations of 14 months among adults and 5-7 months among children in the MEPS, and 8 months (adults) and 4 months (children) in the SIPP. The use of panel survey data to study insurance dynamics presents a unique set of methodological challenges. Researchers should consider key analytic and survey design trade-offs when choosing which survey can best suit their research goals. © Health Research and Educational Trust.

  8. The insurance effect on prescription drug expenditures among the elderly: findings from the 1997 Medical Expenditure Panel Survey.

    PubMed

    Curtis, Lesley H; Law, Amy W; Anstrom, Kevin J; Schulman, Kevin A

    2004-05-01

    Despite continuing debate over a prescription drug benefit for the Medicare program, there has been relatively little research estimating the potential cost of providing such a benefit. The objective of this study was to estimate the effect of prescription drug insurance on outpatient prescription drug expenditures among the elderly. We studied respondents aged > or =65 years to the 1997 Medical Expenditure Panel Survey, a representative survey of the U.S. noninstitutionalized population. Survey-weighted linear regression models were used to estimate the probability of any expenditures and total expenditures while controlling for sociodemographic characteristics, chronic conditions, and health status. We used prescription drug insurance status and outpatient prescription drug expenditures. An estimated 34 million elderly people filled 630 million prescriptions in 1997. Thirty-seven percent did not have prescription drug insurance. Total prescription drug expenditures exceeded $23 billion. Persons without prescription drug insurance spent slightly less than $7 billion; those with insurance spent more than $16 billion. After controlling for health status, comorbidity, and demographic characteristics, prescription drug insurance increased expenditures by $183 per person. The marginal increase in total expenditures of extending the average observed benefit to those currently uninsured is $2.3 billion (95% confidence interval, $1.2-3.5 billion). Proposals for a Medicare drug benefit provide high copayments to protect against insurance effects and to address uncertainty in cost estimates of the proposed benefit. By quantifying the insurance effect on expenditures among the elderly, the data reported here could reduce uncertainty in the budget estimation process.

  9. The Amt/Mep/Rh family of ammonium transport proteins.

    PubMed

    Andrade, Susana L A; Einsle, Oliver

    2007-01-01

    The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural information on two prokaryotic Amt proteins has significantly contributed to our understanding of this class, but basic questions concerning the transport mechanism and the nature of the transported substrate, NH3 or [NH4(+)], remain to be answered. Here we review functional and structural studies on Amt proteins and discuss the bioenergetic issues raised by the various mechanistic proposals present in the literature.

  10. Selection of population controls for a Salmonella case-control study in the UK using a market research panel and web-survey provides time and resource savings.

    PubMed

    Mook, P; Kanagarajah, S; Maguire, H; Adak, G K; Dabrera, G; Waldram, A; Freeman, R; Charlett, A; Oliver, I

    2016-04-01

    Timely recruitment of population controls in infectious disease outbreak investigations is challenging. We evaluated the timeliness and cost of using a market research panel as a sampling frame for recruiting controls in a case-control study during an outbreak of Salmonella Mikawasima in the UK in 2013. We deployed a web-survey by email to targeted members of a market research panel (panel controls) in parallel to the outbreak control team interviewing randomly selected public health staff by telephone and completing paper-based questionnaires (staff controls). Recruitment and completion of exposure history web-surveys for panel controls (n = 123) took 14 h compared to 15 days for staff controls (n = 82). The average staff-time cost per questionnaire for staff controls was £13·13 compared to an invoiced cost of £3·60 per panel control. Differences in the distribution of some exposures existed between these control groups but case-control studies using each group found that illness was associated with consumption of chicken outside of the home and chicken from local butchers. Recruiting market research panel controls offers time and resource savings. More rapid investigations would enable more prompt implementation of control measures. We recommend that this method of recruiting controls is considered in future investigations and assessed further to better understand strengths and limitations.

  11. How do social activities mitigate informal caregivers' psychological distress? Evidence from a nine-year panel survey in Japan.

    PubMed

    Oshio, Takashi; Kan, Mari

    2016-08-22

    It is well known that informal caregiving negatively affects caregivers' mental health, while social activities improve mental health outcomes among middle-aged and elderly individuals. The goal of the present study was to examine how participation in social activities affected the trajectory of an informal caregiver's psychological distress. We used the data from a nationwide nine-wave panel survey of the middle-aged individuals (aged 50-59 years at baseline) in Japan conducted in 2005-13 (N = 24,193 individuals;12,352 women and 11,841 men), mainly focusing on the respondents beginning to provide informal caregiving during the survey period. We employed linear mixed-effects models to explain how the trajectory of psychological distress, measured by Kessler 6 (K6) scores, was associated with caregiving commencement and duration, as well as social activity participation. Participation in social activities was associated with mitigated K6 scores at caregiving commencement by 66.2 and 58.2 % for women and men, respectively. After caregiving started, participation in social activities reduced the average rise in K6 scores, per year, by 65.6 and 89.6 % for women and men, respectively. We observed similar results when focusing on participation before caregiving commencement to avoid endogeneity problems. Results suggest that participation in social activities can alleviate caregivers' psychological distress. Policy measures to support social activities are recommended for the health and well-being of current and potential caregivers.

  12. The Impact of Increased Tax Subsidies on the Insurance Coverage of Self-Employed Families: Evidence from the 1996-2004 Medical Expenditure Panel Survey

    ERIC Educational Resources Information Center

    Selden, Thomas M.

    2009-01-01

    The share of health insurance premiums that self-employed workers can deduct when computing federal income taxes rose from 30 percent in 1996 to 100 percent in 2003. Data from the 1996-2004 Medical Expenditure Panel Survey are used to show that the increased tax subsidy was associated with substantial increases in private coverage among…

  13. Depression as a psychosocial consequence of occupational injury in the US working population: findings from the medical expenditure panel survey

    PubMed Central

    2013-01-01

    Background Empirical evidence describing the psychosocial consequences of occupational injury is still limited. The effect of occupational injury on depression might pose unique challenges in workers compared with other kinds of injury. This study aimed to assess the differential impact of workplace injury compared with non-workplace injury on depression over time, and to identify the potential risk factors associated with post-injury depression in the US working population. Methods Using pooled panel data from the Medical Expenditure Panel Survey 2000–2006, a total of 35,155 workers aged 18–64 years who had been followed for about 18 months in each panel were analyzed. Injuries in the 4–5 months before baseline, and subsequent depression incidence during follow-up, were identified using ICD-9 codes for the medical conditions captured in personal interviews. A discrete time-proportional odds model was used. Results A total of 5.5% of workers with occupational injury at baseline reported depression at follow-up, compared with 4.7% of workers with non-occupational injury and 3.1% of workers without injuries. Those with occupational injuries had more severe injuries and required longer treatment, compared with those with non-occupational injuries. Only 39% of workers with workplace injuries were paid Workers’ Compensation (WC). The association between injury and depression appeared to be stronger for workplace injury, and the adjusted odds ratio for depression was 1.72 for those with occupational injury (95% CI: 1.27–2.32), and 1.36 for those with non-occupational injury (95% CI: 1.07–1.65) compared with the no-injury group, after controlling for relevant covariates. Occupational injury was associated with higher odds of developing depression over time. WC as a source of medical payment was associated with 33% higher odds of developing depression (95% CI: 1.01–1.74). Part-time work, shorter job tenure, and long working hours were independently

  14. Motor-evoked potentials (MEP) during brainstem surgery to preserve corticospinal function.

    PubMed

    Sarnthein, Johannes; Bozinov, Oliver; Melone, Angelina Graziella; Bertalanffy, Helmut

    2011-09-01

    Brainstem surgery bears a risk of damage to the corticospinal tract (CST). Motor-evoked potentials (MEPs) are used intraoperatively to monitor CST function in order to detect CST damage at a reversible stage and thus impede permanent neurological deficits. While the method of MEP is generally accepted, warning criteria in the context of brainstem surgery still have to be agreed on. We analyzed 104 consecutive patients who underwent microsurgical resection of lesions affecting the brainstem. Motor grade was documented prior to surgery, early postoperatively and at discharge. A baseline MEP stimulation intensity threshold was defined and intraoperative testing aimed to keep MEP response amplitude constant. MEPs were considered deteriorated and the surgical team was notified whenever the threshold was elevated by ≥20 mA or MEP response fell under 50%. On the first postoperative day, 18 patients experienced new paresis that resolved by discharge in 11. MEPs deteriorated in 39 patients, and 16 of these showed new postoperative paresis, indicating a 41% risk of new paresis. In the remaining 2/18 patients, intraoperative MEPs were stable, although new paresis appeared postoperatively. In one of these patients, intraoperative hemorrhage caused postoperative swelling, and the new motor deficit persisted until discharge. Of all 104 patients, 7 deteriorated in motor grade at discharge, 92 remained unchanged, and 5 patients have improved. Adjustment of surgical strategy contributed to good motor outcome in 33/39 patients. MEP monitoring may help significantly to prevent motor deficits during demanding neurosurgical procedures on the brainstem.

  15. The Burden of Obesity on Diabetes in the United States: Medical Expenditure Panel Survey, 2008 to 2012.

    PubMed

    Leung, Man Yee Mallory; Carlsson, Nils P; Colditz, Graham A; Chang, Su-Hsin

    2017-01-01

    Diabetes is one of the most prevalent and costly chronic diseases in the United States. To analyze the risk of developing diabetes and the annual cost of diabetes for a US general population. Data from the Medical Expenditure Panel Survey, 2008 to 2012, were used to analyze 1) probabilities of developing diabetes and 2) annual total health care expenditures for diabetics. The age-, sex-, race-, and body mass index (BMI)-specific risks of developing diabetes were estimated by fitting an exponential survival function to age at first diabetes diagnosis. Annual health care expenditures were estimated using a generalized linear model with log-link and gamma variance function. Complex sampling designs in the Medical Expenditure Panel Survey were adjusted for. All dollar values are presented in 2012 US dollars. We observed a more than 6 times increase in diabetes risks for class III obese (BMI ≥ 40 kg/m(2)) individuals compared with normal-weight individuals. Using age 50 years as an example, we found a more than 3 times increase in annual health care expenditures for those with diabetes ($13,581) compared with those without diabetes ($3,954). Compared with normal-weight (18.5 ≤ BMI < 25 kg/m(2)) individuals, class II obese (35 ≤ BMI < 40 kg/m(2)) and class III obese (BMI ≥ 40 kg/m(2)) individuals incurred an annual marginal cost of $628 and $756, respectively. The annual health care expenditure differentials between those with and without diabetes of age 50 years were the highest for individuals with class II ($12,907) and class III ($9,703) obesity. This article highlights the importance of obesity on diabetes burden. Our results suggested that obesity, in particular, class II and class III (i.e., BMI ≥ 35 kg/m(2)) obesity, is associated with a substantial increase in the risk of developing diabetes and imposes a large economic burden. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All

  16. School context, friendship ties and adolescent mental health: A multilevel analysis of the Korean Youth Panel Survey (KYPS).

    PubMed

    Kim, Harris Hyun-Soo

    2015-11-01

    Research on the social determinants of health suggests that interpersonal networks play a critical role in facilitating individual mental and physical well-being. Prior studies also indicate that ecological or contextual factors contribute to positive health outcomes. This study extends prior research by examining the factors associated with adolescent health in an Asian context. Based on the multilevel analysis of the Korean Youth Panel Survey (2006 & 2007), a longitudinal project funded by the Korean government, it investigates some of the key variables related to the mental health of Korean students. Much of previous research focuses on the functions of social capital. This study contributes to the social epidemiology literature by investigating the possible downside of network ties. Specifically, it asks whether having delinquent friends is associated with negative mental health experiences. In addition, little research has been conducted concerning the associations between adolescent health outcomes and school characteristics. This study moves in that direction by examining the relationship between mental well-being of students and a variety of school related variables (e.g., subjective attitude toward school and quality of relationship with peers and teachers). Hierarchical linear modeling shows that, among the social capital control variables, being properly integrated into the family and frequent peer interaction significantly add to mental health. At the individual (student) level only, ties to delinquent friends are negatively associated with mental health, while at both individual and contextual levels, school characteristics are positively related to adolescent subjective well-being. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Beverage caffeine intake in US consumers and subpopulations of interest: estimates from the Share of Intake Panel survey.

    PubMed

    Knight, C A; Knight, I; Mitchell, D C; Zepp, J E

    2004-12-01

    Concerns exist about the potential adverse health effects of high consumption of dietary caffeine, especially in children and pregnant women. Recommended caffeine intakes corresponding to no adverse health effects have been suggested recently for healthy adults (400-450 mg/day), for women contemplating pregnancy (300 mg/day), and for young children age 4-6 years (45 mg/day). To determine whether current caffeine intake approaches these levels, intake from major dietary sources (coffee, tea and carbonated soft drinks) were measured in 10,712 caffeinated beverage consumers in the 1999 US Share of Intake Panel, a targeted beverage survey. Mean caffeine intakes in adult caffeinated beverage consumers ranged from 106 to 170 mg/day (90th percentile intake was 227-382 mg/day). In children 1-5 and 6-9 years, mean caffeine intakes were 14 and 22 mg/day, respectively; corresponding 90th percentile intakes were 37 and 45 mg/day. Pregnant women consumed an average of 58 mg/day (157 mg/day at the 90th percentile), and women of reproductive age ingested 91-109 mg/day (229-247 mg/day at the 90th percentile). These data show that while mean caffeine intakes are within recommended safe levels, heavy consumers of certain subpopulations, including young children and women contemplating pregnancy, might benefit from dietary advice.

  18. Racial/Ethnic Disparities in Primary Care Quality Among Type 2 Diabetes Patients, Medical Expenditure Panel Survey, 2012

    PubMed Central

    Hu, Ruwei; Shi, Leiyu; Liang, Hailun; Haile, Geraldine Pierre

    2016-01-01

    Introduction Racial and ethnic disparities exist in diabetes prevalence, access to diabetes care, diabetes-related complications and mortality rates, and the quality of diabetes care among Americans. We explored racial and ethnic disparities in primary care quality among Americans with type 2 diabetes. Methods We analyzed data on adults with type 2 diabetes derived from the household component of the 2012 Medical Expenditure Panel Survey. Multiple regression and multivariate logistic regressions were used to examine the association between race/ethnicity and primary care attributes related to first contact, longitudinality, comprehensiveness, and coordination, and clusters of confounding factors were added sequentially. Results Preliminary findings indicated differences in primary care quality between racial/ethnic minorities and whites across measures of first contact, longitudinality, comprehensiveness, and coordination. After controlling for confounding factors, these differences were no longer apparent; all racial/ethnic categories showed similar rates of primary care quality according to the 4 primary care domains of interest in the study. Conclusion Results indicate equitable primary care quality for type 2 diabetes patients across 4 key domains of primary care after controlling for socioeconomic characteristics. Additional research is necessary to support these findings, particularly when considering smaller racial/ethnic groups and investigating outcomes related to diabetes. PMID:27490365

  19. The association between smoking and subsequent suicide-related outcomes in the National Comorbidity Survey panel sample

    PubMed Central

    Kessler, Ronald C.; Borges, Guilherme; Sampson, Nancy; Miller, Matthew; Nock, Matthew K.

    2009-01-01

    Controversy exists about whether the repeatedly-documented associations between smoking and subsequent suicide-related outcomes (SROs; ideation, plans, gestures, and attempts) are due to unmeasured common causes or to causal effects of smoking on SROs. We address this issue by examining associations of smoking with subsequent SROs with and without controls for potential explanatory variables in the National Comorbidity Survey (NCS) panel. The latter consists of 5001 people who participated in both the 199002 NCS and the 2001–03 NCS Follow-up Survey. Explanatory variables include socio-demographics, potential common causes (parental history of mental-substance disorders; other respondent childhood adversities) and potential mediators (respondent history of DSM-III-R mental-substance disorders). Small gross (i.e., without controls) prospective associations are found between history of early-onset nicotine dependence and both subsequent suicide ideation and, among ideators, subsequent suicide plans. None of the baseline smoking measures, though, predicts subsequent suicide gestures or attempts among ideators. The smoking-ideation association largely disappear, but the association of early-onset nicotine dependence with subsequent suicide plans persists (Odds-ratio = 3.0), after adjustment for control variables. However, the latter association is as strong with remitted as active nicotine dependence, arguing against a direct causal effect of nicotine dependence on suicide plans. Decomposition of the control variable effects, furthermore, suggests that these effects are due to common causes more than to mediators. These results refine our understanding of the ways in which smoking is associated with later SROs and for the most part argue against the view that these associations are due to causal effects of smoking. PMID:18645572

  20. Antimicrobial Prescribing in Dogs and Cats in Australia: Results of the Australasian Infectious Disease Advisory Panel Survey.

    PubMed

    Hardefeldt, L Y; Holloway, S; Trott, D J; Shipstone, M; Barrs, V R; Malik, R; Burrows, M; Armstrong, S; Browning, G F; Stevenson, M

    2017-07-01

    Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. A cross-sectional study was performed over 4 months in 2011. Respondents were asked about their choices of antimicrobials for empirical therapy of diseases in dogs and cats, duration of therapy, and selection based on culture and susceptibility testing, for common conditions framed as case scenarios: 11 medical, 2 surgical, and 8 dermatological. A total of 892 of the 1,029 members of the Australian veterinary profession that completed the survey satisfied the selection criteria. Empirical antimicrobial therapy was more common for acute conditions (76%) than chronic conditions (24%). Overall, the most common antimicrobial classes were potentiated aminopenicillins (36%), fluoroquinolones (15%), first- and second-generation cephalosporins (14%), and tetracyclines (11%). Third-generation cephalosporins were more frequently used in cats (16%) compared to dogs (2%). Agreement with Australasian Infectious Disease Advisory Panel (AIDAP) guidelines (generated subsequently) was variable ranging from 0 to 69% between conditions. Choice of antimicrobials by Australian veterinary practitioners was generally appropriate, with relatively low use of drugs of high importance, except for the empirical use of fluoroquinolones in dogs, particularly for otitis externa and 3rd-generation cephalosporins in cats. Future surveys will determine whether introduction of the 2013 AIDAP therapeutic guidelines has influenced prescribing habits. Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

  1. What Should Dental Services for People with Disabilities Be Like? Results of an Irish Delphi Panel Survey

    PubMed Central

    Mac Giolla Phadraig, Caoimhin; Nunn, June; Dougall, Alison; O'Neill, Eunan; McLoughlin, Jacinta; Guerin, Suzanne

    2014-01-01

    Background This study aimed to generate prioritised goals for oral health services for people with disabilities as a first step in meeting the need for evidence based oral health services for people with disabilities in Ireland. Methods The study used a three round modified e-Delphi method, involving dental service professionals and people with disabilities or their representatives, in Ireland. Three rounds were completed online using SurveyMonkey. Round 1 asked: “List what you think dental services for people with disabilities in Ireland should be like.” Items for subsequent rounds were generated from responses to Round 1. Round 2 and Round 3 used 5 point Likert scales to rank these items by priority: from No Priority (1) to Top Priority (5). Consensus was achieved on each item where at least 80% of respondents considered an item either High or Top Priority. A consensus meeting concluded the process. Results Sixty-one panelists started and 48 completed the survey. The Delphi panel agreed on level of priority for 69 items and generated 16 consensus statements. These statements covered a range of topics such as access to care, availability of information and training, quality of care, dental treatment and cost. A recurrent theme relating to the appropriateness of care to individual need arose across topics suggesting a need to match service delivery according to the individual's needs, wants and expectations rather than the disability type/diagnosis based service which predominates today. Conclusions This process produced a list of prioritised goals for dental services for people with disabilities. This creates a foundation for building evidence-based service models for people with disabilities in Ireland. PMID:25420015

  2. The association between smoking and subsequent suicide-related outcomes in the National Comorbidity Survey panel sample.

    PubMed

    Kessler, R C; Borges, G; Sampson, N; Miller, M; Nock, M K

    2009-12-01

    Controversy exists about whether the repeatedly documented associations between smoking and subsequent suicide-related outcomes (SROs; ideation, plans, gestures and attempts) are due to unmeasured common causes or to causal effects of smoking on SROs. We address this issue by examining associations of smoking with subsequent SROs with and without controls for potential explanatory variables in the National Comorbidity Survey (NCS) panel. The latter consists of 5001 people who participated in both the 1990-2002 NCS and the 2001-2003 NCS follow-up survey. Explanatory variables include sociodemographics, potential common causes (parental history of mental-substance disorders; other respondent childhood adversities) and potential mediators (respondent history of Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised mental-substance disorders). Small gross (that is, without controls) prospective associations are found between history of early-onset nicotine dependence and both subsequent suicide ideation and, among ideators, subsequent suicide plans. None of the baseline smoking measures, though, predicts subsequent suicide gestures or attempts among ideators. The smoking-ideation association largely disappear, but the association of early-onset nicotine dependence with subsequent suicide plans persists (odds ratio=3.0), after adjustment for control variables. However, the latter association is as strong with remitted as active nicotine dependence, arguing against a direct causal effect of nicotine dependence on suicide plans. Decomposition of the control variable effects, furthermore, suggests that these effects are due to common causes more than to mediators. These results refine our understanding of the ways in which smoking is associated with later SROs and for the most part argue against the view that these associations are due to causal effects of smoking.

  3. Polypharmacy and Health-Related Quality of Life Among US Adults With Arthritis, Medical Expenditure Panel Survey, 2010–2012

    PubMed Central

    Dwibedi, Nilanjana; Sambamoorthi, Usha

    2016-01-01

    Introduction Our objective was to determine the relationship between polypharmacy (treatment with prescription drugs from 6 or more drug classes concurrently) and health-related quality of life (HRQoL) among US adults with arthritis. Methods We conducted a retrospective cohort study that used 2-year longitudinal data from the Medical Expenditure Panel Survey to analyze a cohort of 6,132 adults aged over 21 years with arthritis. Measures of HRQoL were the summary scores from the mental component summary (MCS) and physical component summary (PCS) of the 12-item short-form health survey. Unadjusted and adjusted regression models were used to evaluate the association between polypharmacy and HRQoL measures. We used SAS, version 9.4, (SAS Institute Inc) to conduct all analyses. Results In unadjusted analyses, adults with arthritis taking prescription drugs from 6 or more drug classes concurrently had significantly lower MCS and PCS scores (β, −3.11, P < .001 and β, −10.26, P < .001, respectively) than adults taking prescription drugs from fewer than 6. After controlling for the demographic characteristics, number of mental and physical chronic conditions, and baseline MCS and PCS scores, adults taking prescription drugs from 6 or more drug classes concurrently had significantly lower PCS scores (β, −1.68, P < .001), than those taking prescription drugs from fewer than 6. However, no significant difference in MCS scores was found between adults taking prescription drugs from 6 or more drug classes concurrently and those taking prescription drugs from fewer than 6 (β, −0.27, P = .46). Conclusion Polypharmacy is significantly associated with lower PCS scores among adults with arthritis. Because polypharmacy can lead to drug–drug and drug–disease interactions, health care providers need to consider the risk and adopt a cautious approach in prescribing multiple drugs to manage chronic conditions and in choosing therapies to improve HRQoL among adults with

  4. [Socioeconomic differentials in health and health related behaviors: findings from the Korea Youth Panel Survey].

    PubMed

    Khang, Young-Ho; Cho, Sung-Il; Yang, Seungmi; Lee, Moo-Song

    2005-11-01

    This study examined the socioeconomic differentials for the health and health related behaviors among South Korean middle school students. A nationwide cross-sectional interview survey of 3,449 middle school second-grade students and their parents was conducted using a stratified multi-stage cluster sampling method. The response rate was 93.3%. The socioeconomic position indicators were based on self-reported information from the students and their parents: parental education, father's occupational class, monthly family income, out-of-pocket expenditure for education, housing ownership, educational expectations, educational performance and the perceived economic hardships. The outcome variables that were measured were also based on the self-reported information from the students. The health measures included self-rated health conditions, psychological or mental problems, the feelings of loneliness at school, the overall satisfaction of life and the perceived level of stress. The health related behaviors included were smoking, alcohol drinking, sexual intercourse, violence, bullying and verbal and physical abuse by parents. Socioeconomic differences for the health and health related behaviors were found among the eighth grade boys and girls of South Korea. However, the pattern varied with gender, the socioeconomic position indicators and the outcome measures. The prevalence rates of the overall dissatisfaction with life for both genders differed according to most of the eight socioeconomic position indicators. All the health measures were significantly different according to the perceived economic hardship. However, the socioeconomic differences in the self-rated health conditions and the psychosocial or mental problems were not clear. The students having higher socioeconomic position tended to be a perpetrator of bullying while those students with lower socioeconomic position were more likely to be a victim. The perceived economic hardships predicted the health

  5. 34 CFR 200.89 - MEP allocations; Re-interviewing; Eligibility documentation; and Quality control.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 1 2013-07-01 2013-07-01 false MEP allocations; Re-interviewing; Eligibility...-interviewing; Eligibility documentation; and Quality control. (a) Allocation of funds under the MEP for fiscal... statewide retrospective re-interviewing process that the SEA has conducted. (2)(i) The Secretary conditions...

  6. What Can We Learn From Two Consecutive Cases? Droperidol May Abolish TcMEPs.

    PubMed

    González, Ángel Saponaro; Lorensu, Pedro Javier Pérez; Gómez, Santiago Chaves; Medina, Josué Francisco Nodarse; Dios, Jose Ángel Torres

    2017-02-01

    Droperidol is a D2 receptor antagonist currently used in Europe for preventing postoperative nausea and vomiting. It was used to perform neurolept anaesthesia in combination with fentanyl until a Food and Drug Administration (FDA) 'black box' warning restricted its use due to cardiovascular side effects in 2001. There is no literature regarding the effects of droperidol on transcranial motor evoked potentials (TcMEPs) elicited by electrical stimulation. Our aim was to report two cases of spine surgery in which TcMEPs were lost due to droperidol administration. We report the cases of a 4-year-old male with scoliosis undergoing correction and a 58-year-old woman with metastasis on the D8 vertebrae undergoing kyphosis correction. Intraoperative neurophysiological monitoring was achieved through TcMEPs and somatosensory evoked potentials (SEPs). Intraoperative neurophysiological monitoring (IONM) showed a temporal loss of TcMEPs without SEPs changes coinciding with the administration of droperidol. TcMEP stimulation parameters were changed to double train of pulses, with the aim to elicit them, obtaining responses. Five minutes after droperidol administration, TcMEPs were equal to those at baseline. Droperidol used as prophylaxis for postoperative nausea abolishes TcMEPs. Changing stimulation parameters to double train of pulses, it allows to bypass droperidol central action, achieving monitorable TcMEPs.

  7. What Can We Learn From Two Consecutive Cases? Droperidol May Abolish TcMEPs

    PubMed Central

    González, Ángel Saponaro; Lorensu, Pedro Javier Pérez; Gómez, Santiago Chaves; Medina, Josué Francisco Nodarse; Dios, Jose Ángel Torres

    2017-01-01

    Droperidol is a D2 receptor antagonist currently used in Europe for preventing postoperative nausea and vomiting. It was used to perform neurolept anaesthesia in combination with fentanyl until a Food and Drug Administration (FDA) ‘black box’ warning restricted its use due to cardiovascular side effects in 2001. There is no literature regarding the effects of droperidol on transcranial motor evoked potentials (TcMEPs) elicited by electrical stimulation. Our aim was to report two cases of spine surgery in which TcMEPs were lost due to droperidol administration. We report the cases of a 4-year-old male with scoliosis undergoing correction and a 58-year-old woman with metastasis on the D8 vertebrae undergoing kyphosis correction. Intraoperative neurophysiological monitoring was achieved through TcMEPs and somatosensory evoked potentials (SEPs). Intraoperative neurophysiological monitoring (IONM) showed a temporal loss of TcMEPs without SEPs changes coinciding with the administration of droperidol. TcMEP stimulation parameters were changed to double train of pulses, with the aim to elicit them, obtaining responses. Five minutes after droperidol administration, TcMEPs were equal to those at baseline. Droperidol used as prophylaxis for postoperative nausea abolishes TcMEPs. Changing stimulation parameters to double train of pulses, it allows to bypass droperidol central action, achieving monitorable TcMEPs. PMID:28377841

  8. 78 FR 34346 - Proposed Information Collection; Comment Request; NIST MEP Advanced Manufacturing Jobs and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... National Institute of Standards and Technology Proposed Information Collection; Comment Request; NIST MEP...: National Institute of Standards and Technology (NIST), Commerce. ACTION: Notice. SUMMARY: The Department of... to: Dede McMahon, NIST MEP, 100 Bureau Drive, Stop 4800, Gaithersburg, Maryland 20899-4800; (301-975...

  9. Analysis of four studies in a comparative framework reveals: health linkage consent rates on British cohort studies higher than on UK household panel surveys.

    PubMed

    Knies, Gundi; Burton, Jonathan

    2014-11-27

    A number of cohort studies and longitudinal household panel studies in Great Britain have asked for consent to link survey data to administrative health data. We explore commonalities and differences in the process of collecting consent, achieved consent rates and biases in consent with respect to socio-demographic, socio-economic and health characteristics. We hypothesise that British cohort studies which are rooted within the health sciences achieve higher consent rates than the UK household longitudinal studies which are rooted within the social sciences. By contrast, the lack of a specific health focus in household panel studies means there may be less selectivity in consent, in particular, with respect to health characteristics. Survey designs and protocols for collecting informed consent to health record linkage on two British cohort studies and two UK household panel studies are systematically compared. Multivariate statistical analysis is then performed on information from one cohort and two household panel studies that share a great deal of the data linkage protocol but vary according to study branding, survey design and study population. We find that consent is higher in the British cohort studies than in the UK household panel studies, and is higher the more health-focused the study is. There are no systematic patterns of consent bias across the studies and where effects exist within a study or study type they tend to be small. Minority ethnic groups will be underrepresented in record linkage studies on the basis of all three studies. Systematic analysis of three studies in a comparative framework suggests that the factors associated with consent are idiosyncratic to the study. Analysis of linked health data is needed to establish whether selectivity in consent means the resulting research databases suffer from any biases that ought to be considered.

  10. Causal Inference in Panel Data with Application to Estimating Race-of-Interviewer Effects in the General Social Survey

    ERIC Educational Resources Information Center

    An, Weihua; Winship, Christopher

    2017-01-01

    In this article, we review popular parametric models for analyzing panel data and introduce the latest advances in matching methods for panel data analysis. To the extent that the parametric models and the matching methods offer distinct advantages for drawing causal inference, we suggest using both to cross-validate the evidence. We demonstrate…

  11. Trends in health care expenditure among US adults with heart failure: The Medical Expenditure Panel Survey 2002-2011.

    PubMed

    Echouffo-Tcheugui, Justin B; Bishu, Kinfe G; Fonarow, Gregg C; Egede, Leonard E

    2017-04-01

    Population-based national data on the trends in expenditures related to heart failure (HF) are scarce. Assessing the time trends in health care expenditures for HF in the United States can help to better define the burden of this condition. Using 10-year data (2002-2011) from the national Medical Expenditure Panel Survey (weighted sample of 188,708,194US adults aged ≥18years) and a 2-part model (adjusting for demographics, comorbidities, and time); we estimated adjusted mean and incremental medical expenditures by HF status. The costs were direct total health care expenditures (out-of-pocket payments and payments by private insurance, Medicaid, Medicare, and other sources) from various sources (office-based visits, hospital outpatient, emergency department, inpatient hospital, pharmacy, home health care, and other medical expenditures). Compared with expenditures for individuals without HF ($5511 [95% CI 5405-5617]), individuals with HF had a 4-fold higher mean expenditures of ($23,854 [95% CI 21,733-25,975]). Individuals with HF had $3446 (95% CI 2592-4299) higher direct incremental expenditures compared with those without HF, after adjusting for demographics and comorbidities. Among those with HF, costs continuously increased by $5836 (28% relative increase), from $21,316 (95% CI 18,359-24,272) in 2002/2003 to $27,152 (95% CI 20,066-34,237) in 2010/2011, and inpatient costs ($11,318 over the whole period) were the single largest component of total medical expenditure. The estimated unadjusted total direct medical expenditures for US adults with HF were $30 billion/y and the adjusted total incremental expenditure was $5.8 billion/y. Heart failure is costly and over a recent 10-year period, and direct expenditure related to HF increased markedly, mainly driven by inpatient costs. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: Results of the US Medical Expenditure Panel Survey.

    PubMed

    Caulley, Lisa; Thavorn, Kednapa; Rudmik, Luke; Cameron, Chris; Kilty, Shaun J

    2015-12-01

    Chronic rhinosinusitis (CRS) is an inflammatory disease that affects 2% to 16% of the US population. Despite its increasing prevalence, there are currently limited data in the literature evaluating the economic burden of this disease. This study aimed to determine the direct health care costs of CRS from the perspective of the US government. A prevalence-based approach was used to estimate cost of illness for CRS from the 2011 Medical Expenditure Panel Survey database by using a 4-part model: (1) an estimated sum of all health care expenditures, (2) an attribution model for disease-specific estimation of expenditures, (3) an estimation based on a propensity score model, and (4) estimated disease-specific expenditure by using a linear regression-based approach. A disease prevalence of 3.5% was used. The mean CRS-specific annual expenditure was $5955 (95% CI, $5087-$6823) by using method 1 compared with $5560 (95% CI, $4689-$6431) by using method 2 and $5560 (95% CI, $4653-$6467) by using method 3. The annual expenditure, as estimated by using method 4, was $5589 (95% CI, $4986-$6192). Ambulatory expenses accounted for the largest proportion of expenditures, followed by prescription and in-hospital expenses. This study provided a range of estimates of the direct medical expenditures associated with CRS. We demonstrated that the economic burden attributable to this disease was an estimated $60.2 to $64.5 billion US dollars in 2011, with a wide variation in the total and incremental direct expenditures depending on the type of estimation model used and the prevalence assumed. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  13. Is changing status through housing tenure associated with changes in mental health? Results from the British Household Panel Survey

    PubMed Central

    Popham, Frank; Williamson, Lee; Whitley, Elise

    2015-01-01

    Background Actual or perceived status, such as housing tenure, may impact on health through stress-inducing social comparisons. Studies of how status change impacts mental health change are rare but important because they are less prone to confounding. Methods We used data from the British Household Panel Survey to compare psychological distress in local authority renters who opted to buy their home under the UK's Right to Buy (RTB) policy versus those who continued to rent the same (social non-mover (SNM)) or a different (social mover (SM)) local authority property or who bought privately (owner mover (OM)). General Health Questionnaire (GHQ-12) scores before and after any change in tenure and/or address were compared across groups using a difference-in-difference approach. Results Individuals who moved house (bought or rented) were younger while those who bought (the same or different house) were better off, more likely to be employed, and had higher educational qualifications. Individuals who bought their home (under RTB or privately) had lower distress scores from the outset. Individuals who moved house (bought or rented) experienced a rise in distress prior to moving that was no longer evident 1 year after the move. There was no evidence that changing tenure reduced psychological distress comparing (difference (95% CI)) average GHQ score 2 years preaddress and 1 year postaddress/tenure change in RTB vs SNM, SM, OM: −0.08 (−0.68 to 0.51), 0.16 (−0.70 to 1.01) and −0.17 (−1.28 to 0.94), respectively). Conclusions Changing tenure under RTB did not, on average, impact psychological distress, suggesting that this status change did not change mental health. PMID:25294896

  14. Does active commuting improve psychological wellbeing? Longitudinal evidence from eighteen waves of the British Household Panel Survey.

    PubMed

    Martin, Adam; Goryakin, Yevgeniy; Suhrcke, Marc

    2014-12-01

    The aim of this study is to explore the relationship between active travel and psychological wellbeing. This study used data on 17,985 adult commuters in eighteen waves of the British Household Panel Survey (1991/2-2008/9). Fixed effects regression models were used to investigate how (i.) travel mode choice, (ii.) commuting time, and (iii.) switching to active travel impacted on overall psychological wellbeing and how (iv.) travel mode choice impacted on specific psychological symptoms included in the General Health Questionnaire. After accounting for changes in individual-level socioeconomic characteristics and potential confounding variables relating to work, residence and health, significant associations were observed between overall psychological wellbeing (on a 36-point Likert scale) and (i.) active travel (0.185, 95% CI: 0.048 to 0.321) and public transport (0.195, 95% CI: 0.035 to 0.355) when compared to car travel, (ii.) time spent (per 10minute change) walking (0.083, 95% CI: 0.003 to 0.163) and driving (-0.033, 95% CI: -0.064 to -0.001), and (iii.) switching from car travel to active travel (0.479, 95% CI: 0.199 to 0.758). Active travel was also associated with reductions in the odds of experiencing two specific psychological symptoms when compared to car travel. The positive psychological wellbeing effects identified in this study should be considered in cost-benefit assessments of interventions seeking to promote active travel. Copyright © 2014. Published by Elsevier Inc.

  15. Physicians' Characteristics Associated with Exploring Suicide Risk among Patients with Depression: A French Panel Survey of General Practitioners

    PubMed Central

    Bocquier, Aurélie; Pambrun, Elodie; Dumesnil, Hélène; Villani, Patrick; Verdoux, Hélène; Verger, Pierre

    2013-01-01

    Background General practitioners (GPs) have a key role to play in suicide prevention, but the rates at which they question patients with depression about suicidal thoughts and plans are rather low. Little is known about GPs' characteristics associated with such inquiries. Our objectives were to describe GPs' attitudes, perceived barriers, and self-reported practices in this questioning of these patients and to analyze factors associated with these practices. Methodology This cross-sectional survey was conducted among participants in a panel of randomly selected French GPs (1249/1431 participated: 87.3%). GPs were interviewed with a standardized questionnaire covering their professional and personal characteristics, attitudes, and practices in exploring the suicide risk of their patients with depression. We built a suicide inquiry score by summing the responses to 5 items and used a multiple linear regression analysis to explore the characteristics associated with this score. Principal Findings Most GPs reported inquiring about the presence of suicidal ideation often or very often; less than 30% reported that they frequently explored signs of a specific suicide plan. The mean suicide inquiry score was 12.4 (SD, 2.9; range, 5–20). False ideas, such as thinking that patients who report suicidal ideas do not often commit suicide, were frequent (42.3%). Previous continuing medical education on suicide, participation in a formal mental health network, and patients who committed suicide in the past 5 years were associated with a higher score. Reluctance to question patients about suicide and perception of insufficient skill were associated with a lower score. Conclusions/Significance This study showed great variability in French GPs' practices in exploring suicide risk in patients with depression. Interventions aiming at improving GPs' initial training and continuing medical education in suicide and/or depression, and their collaboration with mental health specialists

  16. Does active commuting improve psychological wellbeing? Longitudinal evidence from eighteen waves of the British Household Panel Survey

    PubMed Central

    Martin, Adam; Goryakin, Yevgeniy; Suhrcke, Marc

    2014-01-01

    Objective The aim of this study is to explore the relationship between active travel and psychological wellbeing. Method This study used data on 17,985 adult commuters in eighteen waves of the British Household Panel Survey (1991/2–2008/9). Fixed effects regression models were used to investigate how (i.) travel mode choice, (ii.) commuting time, and (iii.) switching to active travel impacted on overall psychological wellbeing and how (iv.) travel mode choice impacted on specific psychological symptoms included in the General Health Questionnaire. Results After accounting for changes in individual-level socioeconomic characteristics and potential confounding variables relating to work, residence and health, significant associations were observed between overall psychological wellbeing (on a 36-point Likert scale) and (i.) active travel (0.185, 95% CI: 0.048 to 0.321) and public transport (0.195, 95% CI: 0.035 to 0.355) when compared to car travel, (ii.) time spent (per 10 minute change) walking (0.083, 95% CI: 0.003 to 0.163) and driving (− 0.033, 95% CI: − 0.064 to − 0.001), and (iii.) switching from car travel to active travel (0.479, 95% CI: 0.199 to 0.758). Active travel was also associated with reductions in the odds of experiencing two specific psychological symptoms when compared to car travel. Conclusion The positive psychological wellbeing effects identified in this study should be considered in cost–benefit assessments of interventions seeking to promote active travel. PMID:25152507

  17. Could MEP be useful for parameter tuning in GCM?

    NASA Astrophysics Data System (ADS)

    Pascale, Salvatore; Gregory, Jonathan M.; Ambaum, Maarten; Tailleux, Remi

    2010-05-01

    One of the main uncertainties in General Circulation Model is the presence of empirical parameters. Some of them are very poorly constrained by theory and climate turns out to be very sensitive to them. The idea has been proposed of using entropy production and kinetic energy dissipation as objective functions for parameter tuning (Kunz et al., 2008), relying on the validity of the Maximum Entropy Production conjecture. By using the entropy diagnostics developed for the HadCM3 model (Pascale et al., 2010), we investigate the possibility of applying this idea for two parameters indicated as crucial in the QUMP study (Quantifying Uncertainty in Model Predictions, Murphy et al., 2004), the convection entrainment rate and the cloud-to-droplet conversion rate. A maximum in the APE generation is found for values close to those normally used in HadCM3 while the material entropy production does not show any peak. The experiment also highlights the difficulties in interpreting MEP for complex GCMs and of defining the boundary conditions under which it might be valid.

  18. Patient characteristics associated with multiple pharmacy use in the U.S. population: Findings from the Medical Expenditure Panel Survey.

    PubMed

    Look, Kevin A

    2015-01-01

    Multiple pharmacy use (MPU) is an important safety and quality issue, as it results in fragmented patient care. However, few studies have examined patient characteristics predicting the use of multiple pharmacies, and the findings have been inconsistent. To identify patient characteristics associated with MPU using national data. Data were obtained from the 2011 U.S. Medical Expenditure Panel Survey. The dependent variable was MPU, or the use of more than one pharmacy. The Andersen Behavioral Model of Health Service Use was used to guide the selection of independent variables, which were categorized as predisposing, enabling, and medical need related characteristics. Multivariable logistic regression analysis was conducted to identify the relationships between predisposing, enabling, and need variables and MPU in a hierarchical fashion. Point estimates were weighted to the U.S. non-institutionalized population, and to adjust standard errors to account for the complex survey design. MPU was common, with a national prevalence of 41.3%. Individuals aged 40-64 and adults 65 and older were significantly less likely to use multiple pharmacies as patients aged 18-39 years (40-64 years OR: 0.67, CI: 0.58-0.77; ≥65 years OR: 0.49, CI: 0.41-0.58). Females were significantly more likely to use multiple pharmacies than males (OR: 1.16, CI: 1.05-1.29). Individuals lacking health insurance were more likely to use multiple pharmacies as individuals with private health insurance (OR: 1.42, CI: 1.16-1.73); in contrast, individuals having drug insurance were more likely to use multiple pharmacies (OR: 1.25, CI: 1.06-1.47) relative to those without drug insurance. Any mail order use was the strongest predictor of MPU (OR: 6.94, CI: 5.90-8.18). Pharmacists and other health care providers need to be aware that their patients may be using multiple pharmacies, especially younger patients, those lacking access to health insurance, or those using mail order pharmacies. The findings from

  19. A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites.

    PubMed

    Guggisberg, Ann M; Park, Jooyoung; Edwards, Rachel L; Kelly, Megan L; Hodge, Dana M; Tolia, Niraj H; Odom, Audrey R

    2014-07-24

    Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates commercially important products and is a target for antimicrobial drug development. MEP pathway regulation is poorly understood in microorganisms. Here we employ a forward genetics approach to understand MEP pathway regulation in the malaria parasite, Plasmodium falciparum. The antimalarial fosmidomycin inhibits the MEP pathway enzyme deoxyxylulose 5-phosphate reductoisomerase (DXR). Fosmidomycin-resistant P. falciparum are enriched for changes in the PF3D7_1033400 locus (hereafter referred to as PfHAD1), encoding a homologue of haloacid dehalogenase (HAD)-like sugar phosphatases. We describe the structural basis for loss-of-function PfHAD1 alleles and find that PfHAD1 dephosphorylates a variety of sugar phosphates, including glycolytic intermediates. Loss of PfHAD1 is required for fosmidomycin resistance. Parasites lacking PfHAD1 have increased MEP pathway metabolites, particularly the DXR substrate, deoxyxylulose 5-phosphate. PfHAD1 therefore controls substrate availability to the MEP pathway. Because PfHAD1 has homologues in plants and bacteria, other HAD proteins may be MEP pathway regulators.

  20. AAPM/RSNA physics tutorial for residents: physics of flat-panel fluoroscopy systems: Survey of modern fluoroscopy imaging: flat-panel detectors versus image intensifiers and more.

    PubMed

    Nickoloff, Edward Lee

    2011-01-01

    This article reviews the design and operation of both flat-panel detector (FPD) and image intensifier fluoroscopy systems. The different components of each imaging chain and their functions are explained and compared. FPD systems have multiple advantages such as a smaller size, extended dynamic range, no spatial distortion, and greater stability. However, FPD systems typically have the same spatial resolution for all fields of view (FOVs) and are prone to ghosting. Image intensifier systems have better spatial resolution with the use of smaller FOVs (magnification modes) and tend to be less expensive. However, the spatial resolution of image intensifier systems is limited by the television system to which they are coupled. Moreover, image intensifier systems are degraded by glare, vignetting, spatial distortions, and defocusing effects. FPD systems do not have these problems. Some recent innovations to fluoroscopy systems include automated filtration, pulsed fluoroscopy, automatic positioning, dose-area product meters, and improved automatic dose rate control programs. Operator-selectable features may affect both the patient radiation dose and image quality; these selectable features include dose level setting, the FOV employed, fluoroscopic pulse rates, geometric factors, display software settings, and methods to reduce the imaging time.

  1. Determinants of Obesity and Associated Population Attributability, South Africa: Empirical Evidence from a National Panel Survey, 2008-2012

    PubMed Central

    Sartorius, Benn; Veerman, Lennert J.; Manyema, Mercy; Chola, Lumbwe; Hofman, Karen

    2015-01-01

    Background Obesity is a major risk factor for emerging non-communicable diseases (NCDS) in middle income countries including South Africa (SA). Understanding the multiple and complex determinants of obesity and their true population attributable impact is critical for informing and developing effective prevention efforts using scientific based evidence. This study identified contextualised high impact factors associated with obesity in South Africa. Methods Analysis of three national cross sectional (repeated panel) surveys, using a multilevel logistic regression and population attributable fraction estimation allowed for identification of contextualised high impact factors associated with obesity (BMI>30 kg/m2) among adults (15years+). Results Obesity prevalence increased significantly from 23.5% in 2008 to 27.2% in 2012, with a significantly (p-value<0.001) higher prevalence among females (37.9% in 2012) compared to males (13.3% in 2012). Living in formal urban areas, white ethnicity, being married, not exercising and/or in higher socio-economic category were significantly associated with male obesity. Females living in formal or informal urban areas, higher crime areas, African/White ethnicity, married, not exercising, in a higher socio-economic category and/or living in households with proportionate higher spending on food (and unhealthy food options) were significantly more likely to be obese. The identified determinants appeared to account for 75% and 43% of male and female obesity respectively. White males had the highest relative gain in obesity from 2008 to 2012. Conclusions The rising prevalence of obesity in South Africa is significant and over the past 5 years the rising prevalence of Type-2 diabetes has mirrored this pattern, especially among females. Targeting young adolescent girls should be a priority. Addressing determinants of obesity will involve a multifaceted strategy and requires at individual and population levels. With rising costs in the

  2. Gender differences in the mental health of single parents: New Zealand evidence from a household panel survey.

    PubMed

    Collings, Sunny; Jenkin, Gabrielle; Carter, Kristie; Signal, Louise

    2014-05-01

    In many countries single parents report poorer mental health than partnered parents. This study investigates whether there are gender differences in the mental health of single parents in New Zealand (and whether any gender difference varies with that among partnered parents), and examines key social and demographic mediators that may account for this difference. We used data on 905 single parents and 4,860 partnered parents from a New Zealand household panel survey that included the Kessler-10 measure of psychological distress. Linear regression analyses were used to investigate both interactions of gender and parental status, and confounding or mediation by other covariates. High/very high levels of psychological distress were reported by 15.7 % of single mothers and 9.1 % of single fathers, and 6.1 % of partnered mothers and 4.1 % of partnered fathers. In an Ordinary Least Squares regression of continuous K10 scores on gender, parental status and the interaction of both (plus adjustment for ethnicity, number of children and age), female single parents had a 1.46 higher K10 score than male single parents (95 % CI 0.48-2.44; 1.46). This difference was 0.98 (95 % CI -0.04 to 1.99) points greater than the gender difference among partnered parents. After controlling for further confounding or mediating covariates (educational level, labour force status and socioeconomic deprivation) both the gender difference among single parents (0.38, -0.56 to 1.31) and the interaction of gender and parental status (0.28 greater gender difference among single parents, -0.69 to 1.65) greatly reduced in magnitude and became non-significant, mainly due to adjustment for individual socioeconomic deprivation. The poorer mental health of single parents remains an important epidemiological phenomenon. Although research has produced mixed findings of the nature of gender differences in the mental health of single parents, our research adds to the increasing evidence that it is single

  3. Sex differences in healthcare expenditures among adults with diabetes: evidence from the medical expenditure panel survey, 2002-2011.

    PubMed

    Williams, Joni S; Bishu, Kinfe; Dismuke, Clara E; Egede, Leonard E

    2017-04-11

    The evidence assessing differences in medical costs between men and women with diabetes living in the United States is sparse; however, evidence suggests women generally have higher healthcare expenditures compared to men. Since little is known about these differences, the aim of this study was to assess differences in out-of-pocket (OOP) and total healthcare expenditures among adults with diabetes. Data were used from 20,442 adults (≥18 years of age) with diabetes from the 2002-2011 Medical Expenditure Panel Survey. Dependent variables were OOP and total direct expenditures for multiple health services (prescription, office-based, inpatient, outpatient, emergency, dental, home healthcare, and other services). The independent variable was sex. Covariates included sociodemographic characteristics, comorbid conditions, and time. Sample demographics were summarized. Mean OOP and total direct expenditures for health services by sex status were analyzed. Regression models were performed to assess incremental costs of healthcare expenditures by sex among adults with diabetes. Fifty-six percent of the sample was composed of women. Unadjusted mean OOP costs were higher for women for prescriptions ($1177; 95% CI $1117-$1237 vs. $959; 95% CI $918-$1000; p < 0.001) compared to men. Unadjusted mean total direct expenditures were also higher for women for prescriptions ($3797; 95% CI $3660-$3934 vs. $3334; 95% CI $3208-$3460; p < 0.001) and home healthcare ($752; 95% CI $646-$858 vs. $397; 95% CI $332-$462; p < 0.001). When adjusting for covariates, higher OOP and total direct costs persisted for women for prescription services (OOP: $156; 95% CI $87-$225; p < 0.001 and total: $184; 95% CI $50-$318; p = 0.007). Women also paid > $50 OOP for office-based visits (p < 0.001) and > $55 total expenditures for home healthcare (p = 0.041) compared to men after adjustments. Our findings show women with diabetes have higher OOP and total direct

  4. 77 FR 23462 - Proposed Information Collection; Comment Request; Manufacturing Extension Partnership (MEP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ...; Manufacturing Extension Partnership (MEP) Management Information Reporting AGENCY: National Institute of... McMahon, National Institute of Standards and Technology--Manufacturing Extension Partnership, 100... Deirdre.mcmahon@nist.gov . SUPPLEMENTARY INFORMATION: I. Abstract Sponsored by NIST, the...

  5. Unmanned Multiple Exploratory Probe System (MEPS) for Mars observation. Volume 2: Calculations and derivations

    NASA Technical Reports Server (NTRS)

    Adams, Daniel E.; Crumbly, Christopher M.; Delp, Steve E.; Guidry, Michelle A.; Lisano, Michael E.; Packard, James D.; Striepe, Scott A.

    1988-01-01

    This volume of the final report on the unmanned Multiple Exploratory Probe System (MEPS) details all calculations, derivations, and computer programs that support the information presented in the first volume.

  6. 75 FR 33769 - Manufacturing Extension Partnership (MEP) Availability of Funds for Projects To Develop and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ...: National Institute of Standards and Technology (NIST), Department of Commerce (DOC). ACTION: Notice. SUMMARY: The National Institute of Standards and Technology (NIST) invites proposals from qualified... with the NIST MEP Program's five Strategic Growth Areas (Supply Chain, Sustainability, Technology...

  7. Revisit of the Global Surface Energy Balance Using the MEP Model of Surface Heat Fluxes

    NASA Astrophysics Data System (ADS)

    Deng, Y.; Wang, J.; Park, T. W.; Ming, Y.

    2015-12-01

    The recently proposed model of surface heat fluxes, based on the theory of maximum entropy production (MEP), was used to estimate the global evapotranspiration (ET) and heat fluxes. Compared to bulk transfer models, the MEP model has several remote-sensing-friendly features including fewer input variables, automatic closure of surface energy budget, being independent of bulk gradients of temperature and water vapor, not using wind speed and surface roughness as model parameters, and being less sensitive to uncertainties of input variables and model parameters. The MEP model is formulated for the entire range of soil moisture from dryness to saturation over the land surfaces and has even more advantages over water-snow-ice surfaces compared to traditional methods due to its independence of surface humidity data. The MEP model provides the first global maps of water heat fluxes at ocean surfaces as well as conductive heat fluxes at snow/ice covered polar regions. Ten years of Clouds and the Earth's Radiant Energy System (CERES) earth surface radiation fluxes, surface temperature data products supplemented (when needed) by the Modern-Era Retrospective analysis for Research and Applications (MERRA) surface specific humidity data are used to test the MEP model by comparing the MEP based global annual ET and heat fluxes with existing products. The MEP based fluxes over land surfaces agree closely with previous studies. Over the oceans, the MEP modeled ET tends to be lower than previous estimates while those of sensible heat fluxes are in close agreement with previous studies. A counterpart, "off-line" analysis is also carried out using the NOAA GFDL climate model output from a control experiment and a "warming" experiment. Substantial differences in the warming-related changes of ET and Bowen ratio are found over regions such as North Africa and the southwestern U.S. The implications of these differences for understanding trends and variability in regional energy and

  8. MEP and planetary climates: insights from a two-box climate model containing atmospheric dynamics

    PubMed Central

    Jupp, Tim E.; Cox, Peter M.

    2010-01-01

    A two-box model for equator-to-pole planetary heat transport is extended to include simple atmospheric dynamics. The surface drag coefficient CD is treated as a free parameter and solutions are calculated analytically in terms of the dimensionless planetary parameters η (atmospheric thickness), ω (rotation rate) and ξ (advective capability). Solutions corresponding to maximum entropy production (MEP) are compared with solutions previously obtained from dynamically unconstrained two-box models. As long as the advective capability ξ is sufficiently large, dynamically constrained MEP solutions are identical to dynamically unconstrained MEP solutions. Consequently, the addition of a dynamical constraint does not alter the previously obtained MEP results for Earth, Mars and Titan, and an analogous result is presented here for Venus. The rate of entropy production in an MEP state is shown to be independent of rotation rate if the advective capability ξ is sufficiently large (as for the four examples in the solar system), or if the rotation rate ω is sufficiently small. The model indicates, however, that the dynamical constraint does influence the MEP state when ξ is small, which might be the case for some extrasolar planets. Finally, results from the model developed here are compared with previous numerical simulations in which the effect of varying surface drag coefficient on entropy production was calculated. PMID:20368254

  9. MEP and planetary climates: insights from a two-box climate model containing atmospheric dynamics.

    PubMed

    Jupp, Tim E; Cox, Peter M

    2010-05-12

    A two-box model for equator-to-pole planetary heat transport is extended to include simple atmospheric dynamics. The surface drag coefficient CD is treated as a free parameter and solutions are calculated analytically in terms of the dimensionless planetary parameters eta (atmospheric thickness), omega (rotation rate) and xi (advective capability). Solutions corresponding to maximum entropy production (MEP) are compared with solutions previously obtained from dynamically unconstrained two-box models. As long as the advective capability xi is sufficiently large, dynamically constrained MEP solutions are identical to dynamically unconstrained MEP solutions. Consequently, the addition of a dynamical constraint does not alter the previously obtained MEP results for Earth, Mars and Titan, and an analogous result is presented here for Venus. The rate of entropy production in an MEP state is shown to be independent of rotation rate if the advective capability xi is sufficiently large (as for the four examples in the solar system), or if the rotation rate omega is sufficiently small. The model indicates, however, that the dynamical constraint does influence the MEP state when xi is small, which might be the case for some extrasolar planets. Finally, results from the model developed here are compared with previous numerical simulations in which the effect of varying surface drag coefficient on entropy production was calculated.

  10. The Effects of Survey Administration on Disclosure Rates to Sensitive Items Among Men: A Comparison of an Internet Panel Sample with a RDD Telephone Sample

    PubMed Central

    Hines, Denise A.; Douglas, Emily M.; Mahmood, Sehar

    2010-01-01

    Research using Internet surveys is an emerging field, yet research on the legitimacy of using Internet studies, particularly those targeting sensitive topics, remains under-investigated. The current study builds on the existing literature by exploring the demographic differences between Internet panel and RDD telephone survey samples, as well as differences in responses with regard to experiences of intimate partner violence perpetration and victimization, alcohol and substance use/abuse, PTSD symptomatology, and social support. Analyses indicated that after controlling for demographic differences, there were few differences between the samples in their disclosure of sensitive information, and that the online sample was more socially isolated than the phone sample. Results are discussed in terms of their implications for using Internet samples in research on sensitive topics. PMID:20948972

  11. The Effects of Survey Administration on Disclosure Rates to Sensitive Items Among Men: A Comparison of an Internet Panel Sample with a RDD Telephone Sample.

    PubMed

    Hines, Denise A; Douglas, Emily M; Mahmood, Sehar

    2010-11-01

    Research using Internet surveys is an emerging field, yet research on the legitimacy of using Internet studies, particularly those targeting sensitive topics, remains under-investigated. The current study builds on the existing literature by exploring the demographic differences between Internet panel and RDD telephone survey samples, as well as differences in responses with regard to experiences of intimate partner violence perpetration and victimization, alcohol and substance use/abuse, PTSD symptomatology, and social support. Analyses indicated that after controlling for demographic differences, there were few differences between the samples in their disclosure of sensitive information, and that the online sample was more socially isolated than the phone sample. Results are discussed in terms of their implications for using Internet samples in research on sensitive topics.

  12. Null association between workplace social capital and body mass index. Results from a four-wave panel survey among employees in Japan (J-HOPE study).

    PubMed

    Tsuboya, Toru; Tsutsumi, Akizumi; Kawachi, Ichiro

    2016-02-01

    Research on the longitudinal association of workplace social capital and obesity is limited. We sought to investigate the prospective association of social capital in the workplace with body mass index (BMI) among employees in Japan. We used repeat panel surveys from 12 private companies in Japan. In the present study, four annual surveys waves were used, including 8811, 10,608, 9766, and 6249 participants, respectively. The first survey was conducted between October 2010 and December 2011 (response rate = 77.4%), and the following three surveys were conducted at approximately annual intervals. Questionnaires inquiring about workplace social capital, and other characteristics were administered at each survey. Height and weight were objectively measured in 11 companies, and self-reported in one company. Cross-sectional as well as fixed effects analysis of change in social capital and change in BMI were conducted. Analyses were stratified by age, sex, BMI at baseline, and companies. The analysis was conducted in 2015. Over 3 years, approximately 32% of the participants changed their BMI by more than 1 unit, while workplace social capital changed for approximately 78% of the sample. We found no associations between change in workplace social capital and change in BMI. The null association was preserved across analyses stratified by sex, age, overweight/obesity status at baseline, and company. Workplace social capital is not associated with changes in employee BMI. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Isolation and characterization of a cDNA for human MEP/Cathepsin L

    SciTech Connect

    Gal, S.; Gottesman, M.M.

    1987-05-01

    The major excreted acid protease from malignantly transformed mouse cells (MEP) has similar enzymatic properties to Cathepsin L. They have cloned and sequenced the mouse cDNA for this protein. In this work they report the isolation and characterization of a cDNA for human MEP. A 1.6 kb cDNA from an Okayama-Berg library made from mRNA from SV-40 transformed human fibroblasts was isolated by cross-hybridization at low stringency to the mouse cDNA. Sequence analysis shows that the cloned DNA is more than 70% homologous to the mouse DNA within the protein coding region, non-coding 3' and 5' regions being less homologous than this. The deduced amino acid sequence from the single open reading frame is 98% homologous with the partial protein sequence published for human Cathepsin L and 70% homologous to mouse MEP. Northern blots show that mouse and human cells make a similar size message, about 1.8 kb. A Northern blot of human tissues shows the highest levels of MEP/Cathepsin L mRNA in liver, stomach, ovary and small bowel, with lower levels in other tissues. The isolation of this human clone for MEP/Cathepsin L will allow them to determine whether expression of this protease is correlated with tumorigenicity in human cells as it is in the mouse system.

  14. Does Personality Moderate Reaction and Adaptation to Major Life Events? Evidence from the British Household Panel Survey

    PubMed Central

    Yap, Stevie C. Y.; Anusic, Ivana; Lucas, Richard E.

    2012-01-01

    A nationally representative panel study of British households was used to examine the extent to which Big Five personality traits interact with the experience of major life events (marriage, childbirth, unemployment, and widowhood) to predict increases and decreases in life satisfaction following the event. Results show that major life events are associated with changes in life satisfaction, and some of these changes are very long lasting. Personality traits did not have consistent moderating effects on the association between stressful life events and life satisfaction over time. PMID:23049147

  15. [From the discovery of microbial Mep-Amt ammonium transporters to human Rhesus factors].

    PubMed

    Boeckstaens, Mélanie

    2016-04-01

    Ammonium, ubiquitous on Earth, plays major and distinct roles in most organisms. While it can be a nitrogen source for many microorganisms and plants, it is a cytotoxic metabolic product actively detoxified by the liver in animals. Furthermore, in the latter, ammonium synthesis in the kidney is involved in acid/base homeostasis. Ammonium transport is ensured by a family of proteins, called Mep-Amt-Rh. This family is conserved in all domains of life and comprises the human Rh factors, notably known in transfusional medicine. While the study of bacterial, fungal and vegetal Mep-Amt transporters reveals a fine-tuned and rapid regulation of these proteins in function of environmental changes, the regulation of animal Rh proteins has been poorly addressed. This review notably highlights the importance of the yeast model in the study of the regulation of these proteins as well as in the functional characterization of Mep-Amt-Rh members of diverse origins.

  16. Panel Discussion

    NASA Astrophysics Data System (ADS)

    Langer, James

    1997-03-01

    Panelists: Arthur Bienenstock, Stanford University Cherry Ann Murray, Lucent Technologies Venkatesh Narayanamurti, University of California-Santa Barbara Paul Peercy, SEMI-SEMATECH Robert Richardson, Cornell University James Roberto, Oak Ridge National Laboratory The Board on Physics and Astronomy is undertaking a series of reassessments of all branches of physics as the foundation of a new physics survey. As part of this project, a Committee on Condensed Matter and Materials Physics has been established under the leadership of Venkatesh Narayanamurti of the University of California-Santa Barbara. The committee has been working since June on a study that will include an illustrative recounting of major recent achievements; identification of new opportunities and challenges facing the field; and articulation-for leaders in government, industry, universities, and the public at large-of the important roles played by the field in modern society. An especially urgent issue is how to maintain the intellectual vitality of condensed matter and materials physics, and its contributions to the well-being of the United States, in an era of limited resources. The forum will feature a panel of materials researchers who are members of the Committee on Condensed Matter and Materials Physics. They will give a brief report on the status of the study and engage in a dialogue with the audience about issues facing the condensed matter and materials physics community. Broad community input is vital to the success of the study. Please come and make your voice heard!

  17. Panel flutter

    NASA Technical Reports Server (NTRS)

    Dowell, E. H.

    1972-01-01

    Criteria are presented for the prediction of panel flutter, determination of its occurrence, design for its prevention, and evaluation of its severity. Theoretical analyses recommended for the prediction of flutter stability boundaries, vibration amplitudes, and frequencies for several types of panels are described. Vibration tests and wind tunnel tests are recommended for certain panels and environmental flow conditions to provide information for design of verification analysis. Appropriate design margins on flutter stability boundaries are given and general criteria are presented for evaluating the severity of possible short-duration, limited-amplitude panel flutter on nonreusable vehicles.

  18. Probability of solar panel clearing events at the Insight landing sites (Mars) from a dust devil track survey

    NASA Astrophysics Data System (ADS)

    Reiss, D.; Lorenz, R. D.

    2015-10-01

    The InSight robotic lander is scheduled to land on Mars in September 2016. InSight was designed to perform the first comprehensive surface-based geophysical investigation of Mars [1]. Passage of vortices may have a number of influences on the geophysical measurements to be made by InSight. Seismic data could be influenced by dust devils and vortices via several mechanisms such as loading of the elastic ground by a surface pressure field which causes a local tilt [e.g. 2]. In addition, the power supply of the InSight instruments is provided by solar arrays. Solar-powered missions on Mars like the Sojourner rover in 1997 were affected by a decline in electrical power output by 0.2-0.3 %per day caused by steadily dust deposition on its horizontal solar panel [3]. The solar-powered Mars Exploration Rovers (MERs) Spirit and Opportunity experienced similar dust deposition rates [4] which led to steady power decrease over time endangering longer rover operation times. The much longer operation times of the rovers were made possible by unanticipated 'dust clearing events' of the solar arrays by wind gust or dust devils [5]. Recent studies imply that dust devils are primarily responsible for those recurrent 'dust clearing events' [6]. In this study we investigate the potential frequency of intense dust devil occurrences at the InSight landing site regions, which are able to remove dust from its solar panels. We analyzed newly formed dust devil tracks within a given time span using multi-temporal HiRISE image data covering the same surface area. Based on these measurements we will give encounter rate predictions of intense (high tangential speed and high pressure drop) dust devils with the InSight lander.

  19. Relationship between Mobile Phone Addiction and the Incidence of Poor and Short Sleep among Korean Adolescents: a Longitudinal Study of the Korean Children & Youth Panel Survey

    PubMed Central

    2017-01-01

    Three of ten teenagers in Korea are addicted to mobile phones. The aim of this study was to examine the relationship between mobile phone addiction and the incidence of poor sleep quality and short sleep duration in adolescents. We used longitudinal data from the Korean Children & Youth Panel Survey conducted by the National Youth Policy Institute in Korea (2011–2013). A total of 1,125 students at baseline were included in this study after excluding those who already had poor sleep quality or short sleep duration in the previous year. A generalized estimating equation was used to analyze the data. High mobile phone addiction (mobile phone addiction score > 20) increased the risk of poor sleep quality but not short sleep duration. We suggest that consistent monitoring and effective intervention programs are required to prevent mobile phone addiction and improve adolescents' sleep quality. PMID:28581275

  20. Relationship between Mobile Phone Addiction and the Incidence of Poor and Short Sleep among Korean Adolescents: a Longitudinal Study of the Korean Children & Youth Panel Survey.

    PubMed

    Lee, Joo Eun; Jang, Sung In; Ju, Yeong Jun; Kim, Woorim; Lee, Hyo Jung; Park, Eun Cheol

    2017-07-01

    Three of ten teenagers in Korea are addicted to mobile phones. The aim of this study was to examine the relationship between mobile phone addiction and the incidence of poor sleep quality and short sleep duration in adolescents. We used longitudinal data from the Korean Children & Youth Panel Survey conducted by the National Youth Policy Institute in Korea (2011-2013). A total of 1,125 students at baseline were included in this study after excluding those who already had poor sleep quality or short sleep duration in the previous year. A generalized estimating equation was used to analyze the data. High mobile phone addiction (mobile phone addiction score > 20) increased the risk of poor sleep quality but not short sleep duration. We suggest that consistent monitoring and effective intervention programs are required to prevent mobile phone addiction and improve adolescents' sleep quality. © 2017 The Korean Academy of Medical Sciences.

  1. Unmanned Multiple Exploratory Probe System (MEPS) for Mars observation. Volume 1: Trade analysis and design

    NASA Technical Reports Server (NTRS)

    Adams, Daniel E.; Crumbly, Christopher M.; Delp, Steve E.; Guidry, Michelle A.; Lisano, Michael E.; Packard, James D.; Striepe, Scott A.

    1988-01-01

    This report presents the unmanned Multiple Exploratory Probe Systems (MEPS), a space vehicle designed to observe the planet Mars in preparation for manned missions. The options considered for each major element are presented as a trade analysis, and the final vehicle design is defined.

  2. 75 FR 6355 - Manufacturing Extension Partnership (MEP) Availability of Funds for Three Regions Including the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... characteristics of the manufacturers in the regional and locally available resources with demonstrated experience working with manufacturers. The proposal should include plans for integration into the MEP national system... to assure appropriate regional distribution, and whether the project duplicates other projects funded...

  3. Cloning and Expression Analysis of MEP Pathway Enzyme-encoding Genes in Osmanthus fragrans

    PubMed Central

    Xu, Chen; Li, Huogeng; Yang, Xiulian; Gu, Chunsun; Mu, Hongna; Yue, Yuanzheng; Wang, Lianggui

    2016-01-01

    The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway is responsible for the biosynthesis of many crucial secondary metabolites, such as carotenoids, monoterpenes, plastoquinone, and tocopherols. In this study, we isolated and identified 10 MEP pathway genes in the important aromatic plant sweet osmanthus (Osmanthus fragrans). Multiple sequence alignments revealed that 10 MEP pathway genes shared high identities with other reported proteins. The genes showed distinctive expression profiles in various tissues, or at different flower stages and diel time points. The qRT-PCR results demonstrated that these genes were highly expressed in inflorescences, which suggested a tissue-specific transcript pattern. Our results also showed that OfDXS1, OfDXS2, and OfHDR1 had a clear diurnal oscillation pattern. The isolation and expression analysis provides a strong foundation for further research on the MEP pathway involved in gene function and molecular evolution, and improves our understanding of the molecular mechanism underlying this pathway in plants. PMID:27690108

  4. 34 CFR 200.89 - MEP allocations; Re-interviewing; Eligibility documentation; and Quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... periodic reviews and evaluations indicate a need to do so. (7) A process for implementing corrective action... documentation; and Quality control. 200.89 Section 200.89 Education Regulations of the Offices of the Department...-interviewing; Eligibility documentation; and Quality control. (a) Allocation of funds under the MEP for...

  5. 78 FR 21109 - Manufacturing Extension Partnership (MEP) Center for Nebraska; Availability of Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    ... Nebraska; Availability of Funds AGENCY: National Institute of Standards and Technology (NIST), United States Department of Commerce (DoC). ACTION: Notice. SUMMARY: NIST invites applications from eligible...-sized manufacturers in the United States. Specifically, NIST seeks applications to re-establish an MEP...

  6. 77 FR 12563 - Manufacturing Extension Partnership (MEP) Centers for South Dakota and Kentucky; Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ... of technologies for both process improvement and new product adoption? a. Linkages. Development of... National Institute of Standards and Technology Manufacturing Extension Partnership (MEP) Centers for South Dakota and Kentucky; Availability of Funds AGENCY: National Institute of Standards and Technology (NIST...

  7. Defining Arthritis for Public Health Surveillance: Methods and Estimates in Four US Population Health Surveys.

    PubMed

    Murphy, Louise B; Cisternas, Miriam G; Greenlund, Kurt J; Giles, Wayne; Hannan, Casey; Helmick, Charles G

    2017-03-01

    To determine the variability of arthritis prevalence in 4 US population health surveys. We estimated annualized arthritis prevalence in 2011-2012, among adults age ≥20 years, using 2 definition methods, both based on self-report: 1) doctor-/health care provider-diagnosed arthritis in the Behavioral Risk Factor Surveillance Survey (BRFSS), National Health and Nutrition Examination Survey (NHANES), National Health Interview Survey (NHIS), and Medical Expenditure Panel Survey (MEPS); and 2) three arthritis definitions based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) criteria in MEPS (National Arthritis Data Workgroup on Arthritis and Other Rheumatic Conditions [NADW-AORC], Clinical Classifications Software [CCS], and Centers for Disease Control and Prevention [CDC]). Diagnosed arthritis prevalence percentages using the surveys were within 3 points of one another (BRFSS 26.2% [99% confidence interval (99% CI) 26.0-26.4], MEPS 26.1% [99% CI 25.0-27.2], NHIS 23.5% [99% CI 22.9-24.1], NHANES 23.0% [99% CI 19.2-26.8]), and those using ICD-9-CM were within 5 percentage points of one another (CCS 25.8% [99% CI 24.6-27.1]; CDC 28.3% [99% CI 27.0-29.6]; and NADW-AORC 30.7% [99% CI 29.4-32.1]). The variation in the estimated number (in millions) affected with diagnosed arthritis was 7.8 (BRFSS 58.5 [99% CI 58.1-59.1], MEPS 59.3 [99% CI 55.6-63.1], NHANES 51.5 [99% CI 37.2-65.5], and NHIS 52.6 [99% CI 50.9-54.4]), and using ICD-9-CM definitions it was 11.1 (CCS 58.7 [99% CI 54.5-62.9], CDC 64.3 [99% CI 59.9-68.6], and NADW 69.9 [99% CI 65.2-74.5]). Most (57-70%) reporting diagnosed arthritis also reported ICD-9-CM arthritis; respondents reporting diagnosed arthritis were older than those meeting ICD-9-CM definitions. Proxy response status affected arthritis prevalence differently across surveys. Public health practitioners and decision makers are frequently charged with choosing a single number to represent arthritis

  8. A Nonresponse Bias Analysis of the Health Information National Trends Survey (HINTS).

    PubMed

    Maitland, Aaron; Lin, Amy; Cantor, David; Jones, Mike; Moser, Richard P; Hesse, Bradford W; Davis, Terisa; Blake, Kelly D

    2017-07-01

    We conducted a nonresponse bias analysis of the Health Information National Trends Survey (HINTS) 4, Cycles 1 and 3, collected in 2011 and 2013, respectively, using three analysis methods: comparison of response rates for subgroups, comparison of estimates with weighting adjustments and external benchmarks, and level-of-effort analysis. Areas with higher concentrations of low socioeconomic status, higher concentrations of young households, and higher concentrations of minority and Hispanic populations had lower response rates. Estimates of health information seeking behavior were higher in HINTS compared to the National Health Interview Survey (NHIS). The HINTS estimate of doctors always explaining things in a way that the patient understands was not significantly different from the same estimate from the Medical Expenditure Panel Survey (MEPS); however, the HINTS estimate of health professionals always spending enough time with the patient was significantly lower than the same estimate from MEPS. A level-of-effort analysis found that those who respond later in the survey field period were less likely to have looked for information about health in the past 12 months, but found only small differences between early and late respondents for the majority of estimates examined. There is some evidence that estimates from HINTS could be biased toward finding higher levels of health information seeking.

  9. Panel methods

    NASA Astrophysics Data System (ADS)

    Srivastava, Ashok

    1993-10-01

    A comprehensive description of panel methods has been given to enable an understanding of the underlying theory and the basic structure of the panel codes for aerodynamic applications. Panel methods have seen peak activity in the industry and remain as yet the sole technique for efficient and practical computations on complex-aircraft configurations. The method of the linearized approach of solving flow problems is well proven and till the turn of the century panel methods will continue to remain as the workhorse for computing aerodynamic characteristics of aircraft shapes in the industry. The alternative Euler and Navier-Stokes solvers have yet to mature for applications to complex shapes, hence panel methods will be in the light for at least another decade.

  10. Intraoperative tractography and motor evoked potential (MEP) monitoring in surgery for gliomas around the corticospinal tract.

    PubMed

    Maesawa, Satoshi; Fujii, Masazumi; Nakahara, Norimoto; Watanabe, Tadashi; Wakabayashi, Toshihiko; Yoshida, Jun

    2010-07-01

    Our goal is to indicate the importance of combining intraoperative tractography with motor-evoked potential (MEP) monitoring for glioma surgery in motor eloquent areas. Tumor removal was performed in 28 patients with gliomas in and around the corticospinal tract (CST), in an operation theater equipped with an integrated high-field intraoperative magnetic resonance imaging and a neuronavigation system. Diffusion-tensor imaging-based tractography of the CST was implemented preoperatively and intraoperatively. When the surgically manipulated area came close to the corticospinal pathway, MEP responses were elicited by subcortical stimulation. Responsive areas were compared with the locations of fibers traced by preoperative and intraoperative tractography. Imaging and functional outcomes were reviewed. Intraoperative tractography demonstrated significant inward or outward shift during surgery. MEP responses were observed around the tract at various intensities, and the distance between MEP responsive sites and intraoperative tractography was significantly correlated with the stimulation intensity (P < 0.01). The distance from preoperative tractography was not correlated. A more than subtotal resection was achieved in 24 patients (85.7%). Transient motor deterioration was seen in 12 patients (42.8%), and a permanent deficit was seen in 1 patient (3.5%). We found that intraoperative tractography demonstrated the location of the CST more accurately than preoperative tractography. The results of the linear regression between distance and stimulation intensity were informative for guiding approaches to tumor remnants without impinging on the CST. The combination of intraoperative tractography and MEP monitoring can enhance the quality of surgery for gliomas in motor eloquent areas. Copyright © 2010 Elsevier Inc. All rights reserved.

  11. Reciprocal relations between effort-reward imbalance at work and adverse health: a three-wave panel survey.

    PubMed

    Shimazu, Akihito; de Jonge, Jan

    2009-01-01

    Siegrist's [1996. Adverse health effects of high-effort/low-reward conditions. Journal of Occupational Health Psychology, 1, 27-41.] Effort-Reward Imbalance (ERI) Model assumes that ERI at one point in time influences health at a later point in time. Empirical cross-sectional and longitudinal findings have supported the influence of ERI on adverse health. However, the ERI model does not explicitly take into account that the relation between ERI and adverse health may be also explained by reversed causal relations, or even reciprocal (bi-directional) relations in which ERI and health mutually influence each other. The present 3-wave panel study among 211 Japanese male blue-collar workers in one construction machinery company examined reciprocal relations between ERI and adverse health (i.e., psychological distress and physical complaints) with a 1-year time-lag per wave. Hypotheses were tested using structural equation modeling (Amos 7.0J). Results showed cross-lagged and causally dominant effects of ERI on both psychological distress and physical complaints after 1 year for both Time 1-Time 2 and Time 2-Time 3. In addition, cross-lagged effects of psychological distress on ERI were found after 1 year for both Time 1-Time 2 and Time 2-Time 3. These findings suggest that (perceived) ERI and employee health influence each other reciprocally rather than uni-directionally, and underline the importance of studying reversed causal effects in the relation between ERI and employee health.

  12. Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

    PubMed Central

    Haymond, Amanda; Johny, Chinchu; Dowdy, Tyrone; Schweibenz, Brandon; Villarroel, Karen; Young, Richard; Mantooth, Clark J.; Patel, Trishal; Bases, Jessica; Jose, Geraldine San; Jackson, Emily R.; Dowd, Cynthia S.; Couch, Robin D.

    2014-01-01

    The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone. Because mammals synthesize isoprenoids via an alternate pathway, the bacterial MEP pathway is an attractive target for novel antibiotic development, necessitated by emerging antibiotic resistance as well as biodefense concerns. The first committed step in the MEP pathway is the reduction and isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to methylerythritol phosphate (MEP), catalyzed by MEP synthase. To facilitate drug development, we cloned, expressed, purified, and characterized MEP synthase from Yersinia pestis. Enzyme assays indicate apparent kinetic constants of KMDXP = 252 µM and KMNADPH = 13 µM, IC50 values for fosmidomycin and FR900098 of 710 nM and 231 nM respectively, and Ki values for fosmidomycin and FR900098 of 251 nM and 101 nM respectively. To ascertain if the Y. pestis MEP synthase was amenable to a high-throughput screening campaign, the Z-factor was determined (0.9) then the purified enzyme was screened against a pilot scale library containing rationally designed fosmidomycin analogs and natural product extracts. Several hit molecules were obtained, most notably a natural product allosteric affector of MEP synthase and a rationally designed bisubstrate derivative of FR900098 (able to associate with both the NADPH and DXP binding sites in MEP synthase). It is particularly noteworthy that allosteric regulation of MEP synthase has not been described previously. Thus, our discovery implicates an alternative site (and new chemical space) for rational drug development. PMID:25171339

  13. Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase).

    PubMed

    Haymond, Amanda; Johny, Chinchu; Dowdy, Tyrone; Schweibenz, Brandon; Villarroel, Karen; Young, Richard; Mantooth, Clark J; Patel, Trishal; Bases, Jessica; San Jose, Geraldine; Jackson, Emily R; Dowd, Cynthia S; Couch, Robin D

    2014-01-01

    The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone. Because mammals synthesize isoprenoids via an alternate pathway, the bacterial MEP pathway is an attractive target for novel antibiotic development, necessitated by emerging antibiotic resistance as well as biodefense concerns. The first committed step in the MEP pathway is the reduction and isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to methylerythritol phosphate (MEP), catalyzed by MEP synthase. To facilitate drug development, we cloned, expressed, purified, and characterized MEP synthase from Yersinia pestis. Enzyme assays indicate apparent kinetic constants of KMDXP = 252 µM and KMNADPH = 13 µM, IC50 values for fosmidomycin and FR900098 of 710 nM and 231 nM respectively, and Ki values for fosmidomycin and FR900098 of 251 nM and 101 nM respectively. To ascertain if the Y. pestis MEP synthase was amenable to a high-throughput screening campaign, the Z-factor was determined (0.9) then the purified enzyme was screened against a pilot scale library containing rationally designed fosmidomycin analogs and natural product extracts. Several hit molecules were obtained, most notably a natural product allosteric affector of MEP synthase and a rationally designed bisubstrate derivative of FR900098 (able to associate with both the NADPH and DXP binding sites in MEP synthase). It is particularly noteworthy that allosteric regulation of MEP synthase has not been described previously. Thus, our discovery implicates an alternative site (and new chemical space) for rational drug development.

  14. Solar panel

    SciTech Connect

    Bayles, B.R.

    1981-09-29

    A solar panel includes a base within which are mounted transversely extending conduits. A heat collector plate in the base is in heat conductive relationship with the conduits for the heating of a fluid medium. The base additionally supports a transparent cover outwardly spaced from the heat collector plate to provide a protective insulative air space over the plate. A manifold communicates one series of panels with those of an adjacent series. A modified base dispenses with a collector plate and is formed so as to define integral lengthwise extending passageways for the solar heated medium. Inserted nipples interconnect the passageways of adjacent panels.

  15. Are there racial disparities in psychotropic drug use and expenditures in a nationally representative sample of men in the United States? Evidence from the Medical Expenditure Panel Survey.

    PubMed

    Pierre, Geraldine; Thorpe, Roland J; Dinwiddie, Gniesha Y; Gaskin, Darrell J

    2014-01-01

    This article sought to determine whether racial disparities exist in psychotropic drug use and expenditures in a nationally representative sample of men in the United States. Data were extracted from the 2000-2009 Medical Expenditure Panel Survey, a longitudinal survey that covers the U.S. civilian noninstitutionalized population. Full-Year Consolidated, Medical Conditions, and Prescribed Medicines data files were merged across 10 years of data. The sample of interest was limited to adult males aged 18 to 64 years, who reported their race as White, Black, Hispanic, or Asian. This study employed a pooled cross-sectional design and a two-part probit generalized linear model for analyses. Minority men reported a lower probability of psychotropic drug use (Black=-4.3%, 95% confidence interval [CI]=[-5.5, -3.0]; Hispanic=-3.8%, 95% CI=[-5.1, -2.6]; Asian=-4.5%, 95% CI=[-6.2, -2.7]) compared with White men. After controlling for demographic, socioeconomic, and health status variables, there were no statistically significant race differences in drug expenditures. Consistent with previous literature, racial and ethnic disparities in the use of psychotropic drugs present problems of access to mental health care and services.

  16. National Beef Tenderness Survey-2010: Warner-Bratzler shear force values and sensory panel ratings for beef steaks from United States retail and food service establishments.

    PubMed

    Guelker, M R; Haneklaus, A N; Brooks, J C; Carr, C C; Delmore, R J; Griffin, D B; Hale, D S; Harris, K B; Mafi, G G; Johnson, D D; Lorenzen, C L; Maddock, R J; Martin, J N; Miller, R K; Raines, C R; VanOverbeke, D L; Vedral, L L; Wasser, B E; Savell, J W

    2013-02-01

    The tenderness and palatability of retail and food service beef steaks from across the United States (12 cities for retail, 5 cities for food service) were evaluated using Warner-Bratzler shear (WBS) and consumer sensory panels. Subprimal postfabrication storage or aging times at retail establishments averaged 20.5 d with a range of 1 to 358 d, whereas postfabrication times at the food service level revealed an average time of 28.1 d with a range of 9 to 67 d. Approximately 64% of retail steaks were labeled with a packer/processor or store brand. For retail, top blade had among the lowest (P < 0.05) WBS values, whereas steaks from the round had the greatest (P < 0.05) values. There were no differences (P > 0.05) in WBS values between moist-heat and dry-heat cookery methods for the top round and bottom round steaks or between enhanced (contained salt or phosphate solution) or nonenhanced steaks. Food service top loin and rib eye steaks had the lowest (P < 0.05) WBS values compared with top sirloin steaks. Retail top blade steaks and food service top loin steaks received among the greatest (P < 0.05) consumer sensory panel ratings compared with the other steaks evaluated. Prime food service rib eye steaks received the greatest ratings (P < 0.05) for overall like, like tenderness, tenderness level, like juiciness, and juiciness level, whereas ungraded rib eye steaks received the lowest ratings (P < 0.05) for like tenderness and tenderness level. The WBS values for food service steaks were greater (P < 0.05) for the Select and ungraded groups compared with the Prime, Top Choice, and Low Choice groups. The WBS values and sensory ratings were comparable to the last survey, signifying that no recent or substantive changes in tenderness have occurred.

  17. Facilitation of motor evoked potentials (MEPs) in first dorsal interosseous (FDI) muscle is dependent on different motor images.

    PubMed

    Yahagi, S; Kasai, T

    1998-10-01

    We investigated changes in motor evoked potentials (MEPs) to explain why mental practice can improve motor performance. MEPs were recorded from right and left first dorsal interosseous (FDI) muscles of 9 normal, right-handed subjects during different motor images of index finger movement: (1) rest, (2) flexion, (3) abduction, (4) extension. A paired t test was used to compare differences of stimulus intensities and MEP amplitudes among conditions. MEP amplitudes significantly increased in both FDI muscles during motor images of flexion and abduction but not of extension. Moreover, MEP amplitudes were larger in flexion than in abduction. These differences were proportional to the amount of real EMG discharge of FDI muscle in the selected direction of index finger movement. With regard to right-left differences, MEP amplitudes in the right FDI muscle were larger than those in the left. The primary motor cortex plays a role in the mental representation of motor acts. Furthermore, the amount of corticomotoneuronal cell activity is affected by the different motor images utilizing the same muscle. Right-left difference of MEP amplitude supports the view of left-hemisphere dominance for motor programming as an aspect of normal brain function among right-handers.

  18. National Trends in Statin Use and Expenditures in the US Adult Population From 2002 to 2013: Insights From the Medical Expenditure Panel Survey.

    PubMed

    Salami, Joseph A; Warraich, Haider; Valero-Elizondo, Javier; Spatz, Erica S; Desai, Nihar R; Rana, Jamal S; Virani, Salim S; Blankstein, Ron; Khera, Amit; Blaha, Michael J; Blumenthal, Roger S; Lloyd-Jones, Donald; Nasir, Khurram

    2017-01-01

    Statins remain a mainstay in the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). To detail the trends in use and total and out-of-pocket (OOP) expenditures associated with statins in a representative US adult population from 2002 to 2013. This retrospective longitudinal cohort study was conducted from January 2002 to December 2013. Demographic, medical condition, and prescribed medicine information of adults 40 years and older between 2002 and 2013 were obtained from the Medical Expenditure Panel Survey database. Estimated trends in statin use, total expenditure, and OOP share among the general adult population, those with established ASCVD, and those at risk for ASCVD. Costs were adjusted to 2013 US dollars using the Gross Domestic Product Index. From 2002 to 2013, more than 157 000 Medical Expenditure Panel Survey participants were eligible for the study (mean [SD] age, 57.7 [39.9] years; 52.1% female). Overall, statin use among US adults 40 years of age and older in the general population increased 79.8% from 21.8 million individuals (17.9%) in 2002-2003 (134 million prescriptions) to 39.2 million individuals (27.8%) in 2012-2013 (221 million prescriptions). Among those with established ASCVD, statin use was 49.8% and 58.1% in 2002-2003 and 2012-2013, respectively, and less than one-third were prescribed as a high-intensity dose. Across all subgroups, statin use was significantly lower in women (odds ratio, 0.81; 95% CI, 0.79-0.85), racial/ethnic minorities (odds ratio, 0.65; 95% CI, 0.61-0.70), and the uninsured (odds ratio, 0.33; 95% CI, 0.30-0.37). The proportion of generic statin use increased substantially, from 8.4% in 2002-2003 to 81.8% in 2012-2013. Gross domestic product-adjusted total cost for statins decreased from $17.2 billion (OOP cost, $7.6 billion) in 2002-2003 to $16.9 billion (OOP cost, $3.9 billion) in 2012-2013, and the mean annual OOP costs for patients decreased from $348 to $94. Brand-name statins were used by

  19. Prior history of FDI muscle contraction: different effect on MEP amplitude and muscle activity.

    PubMed

    Talis, V L; Kazennikov, O V; Castellote, J M; Grishin, A A; Ioffe, M E

    2014-03-01

    Motor evoked potentials (MEPs) in the right first dorsal interosseous (FDI) muscle elicited by transcranial magnetic stimulation of left motor cortex were assessed in ten healthy subjects during maintenance of a fixed FDI contraction level. Subjects maintained an integrated EMG (IEMG) level with visual feedback and reproduced this level by memory afterwards in the following tasks: stationary FDI muscle contraction at the level of 40 ± 5 % of its maximum voluntary contraction (MVC; 40 % task), at the level of 20 ± 5 % MVC (20 % task), and also when 20 % MVC was preceded by either no contraction (0-20 task), by stronger muscle contraction (40-20 task) or by no contraction with a previous strong contraction (40-0-20 task). The results show that the IEMG level was within the prescribed limits when 20 and 40 % stationary tasks were executed with and without visual feedback. In 0-20, 40-20, and 40-0-20 tasks, 20 % IEMG level was precisely controlled in the presence of visual feedback, but without visual feedback the IEMG and force during 20 % IEMG maintenance were significantly higher in the 40-0-20 task than those in 0-20 and 40-20 tasks. That is, without visual feedback, there were significant variations in muscle activity due to different prehistory of contraction. In stationary tasks, MEP amplitudes in 40 % task were higher than in 20 % task. MEPs did not differ significantly during maintenance of the 20 % level in tasks with different prehistory of muscle contraction with and without visual feedback. Thus, in spite of variations in muscle background activity due to different prehistory of contraction MEPs did not vary significantly. This dissociation suggests that the voluntary maintenance of IEMG level is determined not only by cortical mechanisms, as reflected by corticospinal excitability, but also by lower levels of CNS, where afferent signals and influences from other brain structures and spinal cord are convergent.

  20. Reconstruction and Evaluation of the Synthetic Bacterial MEP Pathway in Saccharomyces cerevisiae

    PubMed Central

    Partow, Siavash; Siewers, Verena; Daviet, Laurent; Schalk, Michel; Nielsen, Jens

    2012-01-01

    Isoprenoids, which are a large group of natural and chemical compounds with a variety of applications as e.g. fragrances, pharmaceuticals and potential biofuels, are produced via two different metabolic pathways, the mevalonate (MVA) pathway and the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we attempted to replace the endogenous MVA pathway in Saccharomyces cerevisiae by a synthetic bacterial MEP pathway integrated into the genome to benefit from its superior properties in terms of energy consumption and productivity at defined growth conditions. It was shown that the growth of a MVA pathway deficient S. cerevisiae strain could not be restored by the heterologous MEP pathway even when accompanied by the co-expression of genes erpA, hISCA1 and CpIscA involved in the Fe-S trafficking routes leading to maturation of IspG and IspH and E. coli genes fldA and fpr encoding flavodoxin and flavodoxin reductase believed to be responsible for electron transfer to IspG and IspH. PMID:23285068

  1. Chronic Diseases, Health Behaviors, and Demographic Characteristics as Predictors of Ill Health Retirement: Findings from the Korea Health Panel Survey (2008–2012)

    PubMed Central

    Kang, Young Joong; Kang, Mo-Yeol

    2016-01-01

    Purpose The research aim was to identify demographic characteristics, chronic diseases, and unhealthy behaviors predicting ill health retirement in South Korea. Methods Data were collected from 15,407 individuals enrolled in the first through the fifth phases of the Korea Health Panel Survey (2008–2012) using structured questionnaires examining retirement, morbidities, and health-related behaviors. The Cox proportional hazard model was used to examine demographic and clinical characteristics’ effects on ill health retirement. Lost years of working life expectancy were calculated for demographic and clinical characteristics. Results Older, female, and manual workers were more likely to experience ill health retirement, as were respondents reporting poor health-related habits (e.g., heavy drinking, irregular meals, less sleep hours, obesity, and no regular exercise). The chronic diseases most closely associated with ill health retirement were, in order, psychiatric disease, ophthalmologic disease, neurologic disease, infectious disease, and musculoskeletal diseases. The average reduction in working life expectancy was 9.73 years. Conclusions Our study results can help contribute to the development of strategies for reducing the risk of ill health retirement and promoting sustainable labor force participation in an aging society. PMID:27930661

  2. Impact of Out-of-Pocket Expenditure on Physical Therapy Utilization for Nonspecific Low Back Pain: Secondary Analysis of the Medical Expenditure Panel Survey Data.

    PubMed

    Dolot, Janet; Viola, Deborah; Shi, Qiuhu; Hyland, Matthew

    2016-02-01

    Physical therapy decreases low back pain, improves function, and may lead to decreased use of medical services. However, factors predicting physical therapy utilization for patients with low back pain are not well understood. The purpose of this study was to identify the impact of out-of-pocket expenditure on physical therapy utilization for US adults with nonspecific low back pain. This study was a secondary analysis of retrospective Medical Expenditure Panel Survey data. The participants were US adults with nonspecific low back pain. The outcome variable was the number of visits per episode of care. The research variable was out-of-pocket expenditure. Covariate variables were Medical Outcomes Study 12-Item Short-Form Health Survey (SF-12) component scores. Descriptive statistics and multiple linear regression analyses were performed. Three hundred fourteen adults met the inclusion criteria and submitted SF-12 scores, representing nearly 4 million adults. Out-of-pocket expenditure, physical component score, and the age-insurance category "18-64 years with public coverage only for all of the year or uninsured all of the year" negatively predicted visits per episode of care in the final regression model. Limitations of the study included use of a nonexperimental design, lack of information about symptom severity and content of physical therapy, and SF-12 scores were not taken coincidental with the episode of care. Out-of-pocket expenditure negatively predicts physical therapy utilization. More research is needed to identify all factors influencing physical therapy utilization so that effective health policies may be developed. © 2016 American Physical Therapy Association.

  3. Biosynthesis of β-carotene in engineered E. coli using the MEP and MVA pathways.

    PubMed

    Yang, Jianming; Guo, Lizhong

    2014-11-18

    β-carotene is a carotenoid compound that has been widely used not only in the industrial production of pharmaceuticals but also as nutraceuticals, animal feed additives, functional cosmetics, and food colorants. Currently, more than 90% of commercial β-carotene is produced by chemical synthesis. Due to the growing public concern over food safety, the use of chemically synthesized β-carotene as food additives or functional cosmetic agents has been severely controlled in recent years. This has reignited the enthusiasm for seeking natural β-carotene in large-scale fermentative production by microorganisms. To increase β-carotene production by improving the isopentenyl pyrophosphate (IPP) and geranyl diphospate (GPP) concentration in the cell, the optimized MEP (methylerythritol 4-phosphate) pathway containing 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and isopentenyl pyrophosphate isomerase (FNI) from Bacillus subtilis, geranyl diphosphate synthase (GPPS2) from Abies grandis have been co-expressed in an engineered E. coli strain. To further enhance the production of β-carotene, the hybrid MVA (mevalonate) pathway has been introduced into an engineered E. coli strain, co-expressed with the optimized MEP pathway and GPPS2. The final genetically modified strain, YJM49, can accumulate 122.4±6.2 mg/L β-carotene in flask culture, approximately 113-fold and 1.7 times greater than strain YJM39, which carries the native MEP pathway, and YJM45, which harbors the MVA pathway and the native MEP pathway, respectively. Subsequently, the fermentation process was optimized to enhance β-carotene production with a maximum titer of 256.8±10.4 mg/L. Finally, the fed-batch fermentation of β-carotene was evaluated using the optimized culture conditions. After induction for 56 h, the final engineered strain YJM49 accumulated 3.2 g/L β-carotene with a volumetric productivity of 0.37 mg/(L · h · OD600) in aerobic fed-batch fermentation, and the conversion efficiency

  4. The Mycobacterium tuberculosis MEP (2C-methyl-D-erythritol 4-phosphate) pathway as a new drug target

    PubMed Central

    Eoh, Hyungjin; Brennan, Patrick J.; Crick, Dean C.

    2009-01-01

    Tuberculosis (TB) is still a major public health problem, compounded by the human immunodeficiency virus (HIV)-TB co-infection and recent emergence of multidrug-resistant (MDR) and extensive drug resistant (XDR)-TB. Novel anti-TB drugs are urgently required. In this context, the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway of Mycobacterium tuberculosis has drawn attention; it is one of several pathways vital for M. tuberculosis viability and the human host lacks homologous enzymes. Thus, the MEP pathway promises bacterium-specific drug targets and the potential for identification of lead compounds unencumbered by target-based toxicity. Indeed, fosmidomycin is now known to inhibit the second step in the MEP pathway. This review describes the cardinal features of the main enzymes of the MEP pathway in M. tuberculosis and how these can be manipulated in high throughput screening campaigns in the search for new anti-infectives against TB. PMID:18793870

  5. Panel Sessions.

    ERIC Educational Resources Information Center

    Proceedings of the ASIS Mid-Year Meeting, 1992

    1992-01-01

    Lists the speakers and summarizes the issues addressed for 12 panel sessions on topics related to networking, including libraries and national networks, federal national resources and energy programs, multimedia issues, telecommuting, remote image serving, accessing the Internet, library automation, scientific information, applications of Z39.50,…

  6. Media Panel.

    ERIC Educational Resources Information Center

    Marklund, Inger, Ed.; Hanse, Mona-Britt, Ed.

    1984-01-01

    The Swedish Media Panel is a research program about children and young persons and their use of mass media. The aim of the ten-year (1975-1985) project is to explain how media habits originate, how they change as children grow older, what factors on the part of children themselves and in their surroundings may be connected with a certain use of…

  7. Distinct transport mechanisms in yeast ammonium transport/sensor proteins of the Mep/Amt/Rh family and impact on filamentation.

    PubMed

    Boeckstaens, Mélanie; André, Bruno; Marini, Anna Maria

    2008-08-01

    Ammonium transport proteins of the Mep/Amt/Rh family include microbial and plant Mep/Amt members, crucial for ammonium scavenging, and animal Rhesus factors likely involved in ammonium disposal. Recent structural information on two bacterial Mep/Amt proteins has revealed the presence, in the hydrophobic conducting pore, of a pair of preserved histidines proposed to play an important role in substrate conductance, by participating either in NH(4)(+) deprotonation or in shaping the pore. Here we highlight the existence of two functional Mep/Amt subfamilies distinguishable according to whether the first of these histidines is conserved, as in yeast ScMep2, or replaced by glutamate, as in ScMep1. Replacement of the native histidine of ScMep2 with glutamate leads to conversion from ScMep2 to ScMep1-like properties. This includes a two-unit upshift of the optimal pH for transport and an increase of the transport rate, consistent with alleviation of an energy-limiting step. Similar effects are observed when the same substitution is introduced into the Escherichia coli AmtB protein. In contrast to ScMep1, ScMep2 is proposed to play an additional signaling role in the induction of filamentous growth, a dimorphic change often associated with virulence in pathogenic fungi. We show here that the histidine to glutamate substitution in ScMep2 leads to uncoupling of the transport and sensor functions, suggesting that a ScMep2-specific transport mechanism might be responsible for filamentation. Our overall data suggest the existence of two functional groups of Mep/Amt-type proteins with different transport mechanisms and distinct impacts on cell physiology and signaling.

  8. Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway.

    PubMed

    Zhao, Yaru; Yang, Jianming; Qin, Bo; Li, Yonghao; Sun, Yuanzhang; Su, Sizheng; Xian, Mo

    2011-06-01

    Isoprene is an aviation fuel of high quality and an important polymer building block in the synthetic chemistry industry. In light of high oil prices, sustained availability, and environmental concerns, isoprene from renewable materials is contemplated as a substitute for petroleum-based product. Escherichia coli with advantages over other wild microorganisms, is considered as a powerful host for biofuels and chemicals. Here, we constructed a synthetic pathway of isoprene in E. coli by introducing an isoprene synthase (ispS) gene from Populus nigra, which catalyzes the conversion of dimethylallyl diphosphate (DMAPP) to isoprene. To improve the isoprene production, we overexpressed the native 1-deoxy-D: -xylulose-5-phosphate (DXP) synthase gene (dxs) and DXP reductoisomerase gene (dxr) in E. coli, which catalyzed the first step and the second step of MEP pathway, respectively. The fed-batch fermentation results showed that overexpression of DXS is helpful for the improvement of isoprene production. Surprisingly, heterologous expression of dxs and dxr from Bacillus subtilis in the E. coli expressing ispS resulted in a 2.3-fold enhancement of isoprene production (from 94 to 314 mg/L). The promising results showed that dxs and dxr from B. subtilis functioned more efficiently on the enhancement of isoprene production than native ones. This could be caused by the consequence of great difference in protein structures of the two original DXSs. It could be practical to produce isoprene in E. coli via MEP pathway through metabolic engineering. This work provides an alternative way for production of isoprene by engineered E. coli via MEP pathway through metabolic engineering.

  9. Racial and ethnic differences in health care utilization for childhood eczema: An analysis of the 2001-2013 Medical Expenditure Panel Surveys.

    PubMed

    Fischer, Alexander H; Shin, Daniel B; Margolis, David J; Takeshita, Junko

    2017-09-27

    Eczema is a common chronic inflammatory disease of the skin. Studies suggest differences in disease prevalence and severity by race/ethnicity. Our knowledge of health care utilization for eczema among different racial/ethnic groups remains limited. To evaluate health care utilization for childhood eczema among different racial/ethnic groups in the United States. We performed a cohort study of non-Hispanic white (reference), non-Hispanic black, and Hispanic white individuals under the age of 18 years with caregiver-reported eczema (N = 2043) pooled from the 2-year longitudinal cohorts of the 2001-2013 Medical Expenditure Panel Surveys. Health care utilization outcomes were evaluated over the 2-year follow-up period by race/ethnicity using multivariable regression. Among all children with eczema, non-Hispanic blacks were less likely than whites to report an ambulatory visit for eczema (adjusted odds ratio [ORadj] 0.69; 95% confidence interval [CI] 0.51-0.92). Among those with ≥1 ambulatory visit for eczema, non-Hispanic blacks reported more visits (adjusted incidence rate ratio [IRRadj] 1.68; 95% CI 1.10-2.55) and prescriptions (IRRadj 1.22; 95% CI 1.01-1.46) than whites and were more likely than whites to report a dermatology visit (ORadj 1.82; 95% CI 1.06-3.14) for eczema. We used caregiver- or self-reported data. Our findings suggest disparities in health care utilization for eczema among non-Hispanic black children despite utilization patterns suggestive of more severe disease. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

  10. Enrollment in Private Medical Insurance and Utilization of Medical Services Among Children and Adolescents: Data From the 2009-2012 Korea Health Panel Surveys

    PubMed Central

    Doo, Young-Taek

    2016-01-01

    Objectives: The purposes of this study were to examine the status of children and adolescents with regard to enrollment in private medical insurance (PMI) and to investigate its influence on their utilization of medical services. Methods: The present study assessed 2973 subjects younger than 19 years of age who participated in five consecutive Korea Health Panel surveys from 2009 to 2012. Results: At the initial assessment, less than 20% of the study population had not enrolled in any PMI program, but this proportion decreased over time. Additionally, the number of subjects with more than two policies increased, the proportions of holders of indemnity-type only (‘I’-only) and of fixed amount+indemnity-type (‘F+I’) increased, whereas the proportion of holders with fixed amount-type only (‘F’-only) decreased. Compared with subjects without private insurance, PMI policyholders were more likely to use outpatient and emergency services, and the number of policies was proportionately related to inpatient service utilization. Regarding out-patient care, subjects with ‘F’-only PMI used these services more often than did uninsured subjects (odds ratio [OR], 1.69), whereas subjects with ‘I’-only PMI or ‘F+I’ PMI utilized a broad range of inpatient, outpatient, and emergency services relative to uninsured subjects (ORs for ‘I’-only: 1.39, 1.63, and 1.38, respectively; ORs for ‘F+I’: 1.67, 2.09, and 1.37, respectively). Conclusions: The findings suggest public policy approaches to standardizing PMI contracts, reform in calculation of premiums in PMI, re-examination regarding indemnity insurance products, and mutual control mechanisms to mediate between national health insurance services and private insurers are required. PMID:27055548

  11. Enrollment in Private Medical Insurance and Utilization of Medical Services Among Children and Adolescents: Data From the 2009-2012 Korea Health Panel Surveys.

    PubMed

    Ryu, Dong Hee; Kam, Sin; Doo, Young-Taek

    2016-03-01

    The purposes of this study were to examine the status of children and adolescents with regard to enrollment in private medical insurance (PMI) and to investigate its influence on their utilization of medical services. The present study assessed 2973 subjects younger than 19 years of age who participated in five consecutive Korea Health Panel surveys from 2009 to 2012. At the initial assessment, less than 20% of the study population had not enrolled in any PMI program, but this proportion decreased over time. Additionally, the number of subjects with more than two policies increased, the proportions of holders of indemnity-type only ('I'-only) and of fixed amount+indemnity-type ('F+I') increased, whereas the proportion of holders with fixed amount-type only ('F'-only) decreased. Compared with subjects without private insurance, PMI policyholders were more likely to use outpatient and emergency services, and the number of policies was proportionately related to inpatient service utilization. Regarding out-patient care, subjects with 'F'-only PMI used these services more often than did uninsured subjects (odds ratio [OR], 1.69), whereas subjects with 'I'-only PMI or 'F+I' PMI utilized a broad range of inpatient, outpatient, and emergency services relative to uninsured subjects (ORs for 'I'-only: 1.39, 1.63, and 1.38, respectively; ORs for 'F+I': 1.67, 2.09, and 1.37, respectively). The findings suggest public policy approaches to standardizing PMI contracts, reform in calculation of premiums in PMI, re-examination regarding indemnity insurance products, and mutual control mechanisms to mediate between national health insurance services and private insurers are required.

  12. Impact of changes in mode of travel to work on changes in body mass index: evidence from the British Household Panel Survey

    PubMed Central

    Martin, Adam; Panter, Jenna; Suhrcke, Marc; Ogilvie, David

    2015-01-01

    Background Active commuting is associated with various health benefits, but little is known about its causal relationship with body mass index (BMI). Methods We used cohort data from three consecutive annual waves of the British Household Panel Survey, a longitudinal study of nationally representative households, in 2004/2005 (n=15 791), 2005/2006 and 2006/2007. Participants selected for the analyses (n=4056) reported their usual main mode of travel to work at each time point. Self-reported height and weight were used to derive BMI at baseline and after 2 years. Multivariable linear regression analyses were used to assess associations between switching to and from active modes of travel (over 1 and 2 years) and change in BMI (over 2 years) and to assess dose–response relationships. Results After adjustment for socioeconomic and health-related covariates, the first analysis (n=3269) showed that switching from private motor transport to active travel or public transport (n=179) was associated with a significant reduction in BMI compared with continued private motor vehicle use (n=3090; −0.32 kg/m2, 95% CI −0.60 to −0.05). Larger adjusted effect sizes were associated with switching to active travel (n=109; −0.45 kg/m2, −0.78 to −0.11), particularly among those who switched within the first year and those with the longest journeys. The second analysis (n=787) showed that switching from active travel or public transport to private motor transport was associated with a significant increase in BMI (0.34 kg/m2, 0.05 to 0.64). Conclusions Interventions to enable commuters to switch from private motor transport to more active modes of travel could contribute to reducing population mean BMI. PMID:25954024

  13. Higher levels of psychological distress are associated with a higher risk of incident diabetes during 18 year follow-up: results from the British household panel survey

    PubMed Central

    2012-01-01

    Background Reviews have shown that depression is a risk factor for the development of type 2 diabetes. However, there is limited evidence for general psychological distress to be associated with incident diabetes. The aim of the present study was to test whether persons who report higher levels of psychological distress are at increased risk to develop type 2 diabetes during 18 years follow up, adjusted for confounders. Methods A prospective analysis using data from 9,514 participants (41 years, SD=14; 44% men) of the British Household Panel Survey. The General Health Questionnaire 12 item version was used to assess general psychological distress, diabetes was measured by means of self-report. Cox proportional hazards regression models were used to calculate the multivariate-adjusted hazard ratio (HR) of incident diabetes during 18 years follow up, comparing participants with low versus high psychological distress at baseline (1991). Results A total of 472 participants developed diabetes 18 year follow up. Those with a high level of psychological distress had a 33% higher hazard of developing diabetes (HR=1.33, 95% CI 1.10–1.61), relative to those with a low level of psychological distress, adjusted for age, sex, education level and household income. After further adjustment for differences in level of energy, health status, health problems and activity level, higher psychological distress was no longer associated with incident diabetes (HR=1.10, 95% CI 0.91-1.34). Conclusions Higher levels of psychological distress are a risk factor for the development of diabetes during an 18 year follow up period. This association may be potentially mediated by low energy level and impaired health status. PMID:23259455

  14. Chronic condition combinations and health care expenditures and out-of-pocket spending burden among adults, Medical Expenditure Panel Survey, 2009 and 2011.

    PubMed

    Meraya, Abdulkarim M; Raval, Amit D; Sambamoorthi, Usha

    2015-01-29

    Little is known about how combinations of chronic conditions in adults affect total health care expenditures. Our objective was to estimate the annual average total expenditures and out-of-pocket spending burden among US adults by combinations of conditions. We conducted a cross-sectional study using 2009 and 2011 data from the Medical Expenditure Panel Survey. The sample consisted of 9,296 adults aged 21 years or older with at least 2 of the following 4 highly prevalent chronic conditions: arthritis, diabetes mellitus, heart disease, and hypertension. Unadjusted and adjusted regression techniques were used to examine the association between chronic condition combinations and log-transformed total expenditures. Logistic regressions were used to analyze the relationship between chronic condition combinations and high out-of-pocket spending burden. Among adults with chronic conditions, adults with all 4 conditions had the highest average total expenditures ($20,016), whereas adults with diabetes/hypertension had the lowest annual total expenditures ($7,116). In adjusted models, adults with diabetes/hypertension and hypertension/arthritis had lower health care expenditures than adults with diabetes/heart disease (P < .001). In adjusted models, adults with all 4 conditions had higher expenditures compared with those with diabetes and heart disease. However, the difference was only marginally significant (P = .04). Among adults with arthritis, diabetes, heart disease, and hypertension, total health care expenditures differed by type of chronic condition combinations. For individuals with multiple chronic conditions, such as heart disease and diabetes, new models of care management are needed to reduce the cost burden on the payers.

  15. 61. Upper panel in cornerpower panel lcpa lower panel in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. Upper panel in corner-power panel lcpa lower panel in corner-oxygen regeneration unit, at right-air conditioner control panel, on floor-bio-pack 45 for emergency breathing, looking northwest - Ellsworth Air Force Base, Delta Flight, Launch Control Facility, County Road CS23A, North of Exit 127, Interior, Jackson County, SD

  16. Architectural Panels

    NASA Astrophysics Data System (ADS)

    1985-01-01

    Alliance Wall Corporation's Whyteboard, a porcelain enamel on steel panels wall board, owes its color stability to a KIAC engineering background study to identify potential technologies and manufacturers of equipment which could be used to detect surface flaws. One result of the data base search was the purchase of a spectrocolorimeter which enables the company to control some 250 standard colors, and match special colors.

  17. Architectural Panels

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Alliance Wall Corporation's Whyteboard, a porcelain enamel on steel panels wall board, owes its color stability to a KIAC engineering background study to identify potential technologies and manufacturers of equipment which could be used to detect surface flaws. One result of the data base search was the purchase of a spectrocolorimeter which enables the company to control some 250 standard colors, and match special colors.

  18. Combining panels for forest inventory and analysis estimation

    Treesearch

    Paul L. Patterson; Gregory A. Reams

    2005-01-01

    The term panel denotes a set of samples where the same elements are measured on two or more occasions. Historically, Forest Inventory and Anaysis (FIA) has used a single panel to conduct periodic surveys. Annual panels, however, allow greater flexibility because they can be combined in a variety of ways. Note that FIA assumes complete spatial coverage for each panel...

  19. Test-retest reliability of motor evoked potentials (MEPs) at the submental muscle group during volitional swallowing.

    PubMed

    Doeltgen, Sebastian H; Ridding, Michael C; O'Beirne, Greg A; Dalrymple-Alford, John; Huckabee, Maggie-Lee

    2009-03-30

    Motor evoked potentials (MEPs) recorded from pharyngeal and anterior hyo-mandibular (submental) muscles at rest have been used to evaluate treatment effects on neural pathways underlying swallowing. This study documents a novel methodological approach of recording reliable intra- and inter-session MEPs at the submental muscle group during task-related volitional swallowing. MEPs were elicited by single-pulse transcranial magnetic stimulation (TMS), triggered by a custom-made system when a pre-set level of surface electromyographic activity in the target muscles was breached. Fifteen MEPs were recorded during each of four sessions. Intraclass correlation coefficients (ICCs) were used to assess test-retest reliability within and across sessions for blocks of 3, 5, 10 and 15 trials. Highly reliable intra-session reliability was achieved, maximal for blocks of five trials (0.915). Inter-session reliability varied between 0.474 (three trials per block) and 0.909 (10 trials per block). Surface electromyography-triggered TMS allows reliable measurement of MEP amplitude at the submental muscle group within and across sessions when muscles are pre-activated during volitional swallowing. This methodology will be useful for future investigations on the effects of pathology and modulation of swallowing neural pathways.

  20. Understanding Preferences for Treatment After Hypothetical First-Time Anterior Shoulder Dislocation: Surveying an Online Panel Utilizing a Novel Shared Decision-Making Tool

    PubMed Central

    Streufert, Ben; Reed, Shelby D.; Orlando, Lori A.; Taylor, Dean C.; Huber, Joel C.; Mather, Richard C.

    2017-01-01

    Background: Although surgical management of a first-time anterior shoulder dislocation (FTASD) can reduce the risk of recurrent dislocation, other treatment characteristics, costs, and outcomes are important to patients considering treatment options. While patient preferences, such as those elicited by conjoint analysis, have been shown to be important in medical decision-making, the magnitudes or effects of patient preferences in treating an FTASD are unknown. Purpose: To test a novel shared decision-making tool after sustained FTASD. Specifically measured were the following: (1) importance of aspects of operative versus nonoperative treatment, (2) respondents’ agreement with results generated by the tool, (3) willingness to share these results with physicians, and (4) association of results with choice of treatment after FTASD. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A tool was designed and tested using members of Amazon Mechanical Turk, an online panel. The tool included an adaptive conjoint analysis exercise, a method to understand individuals’ perceived importance of the following attributes of treatment: (1) chance of recurrent dislocation, (2) cost, (3) short-term limits on shoulder motion, (4) limits on participation in high-risk activities, and (5) duration of physical therapy. Respondents then chose between operative and nonoperative treatment for hypothetical shoulder dislocation. Results: Overall, 374 of 501 (75%) respondents met the inclusion criteria, of which most were young, active males; one-third reported prior dislocation. From the conjoint analysis, the importance of recurrent dislocation and cost of treatment were the most important attributes. A substantial majority agreed with the tool’s ability to generate representative preferences and indicated that they would share these preferences with their physician. Importance of recurrence proved significantly predictive of respondents’ treatment choices

  1. The direct health-care burden of valvular heart disease: evidence from US national survey data

    PubMed Central

    Moore, Matt; Chen, Jie; Mallow, Peter J; Rizzo, John A

    2016-01-01

    Purpose This study quantified the overall effects of aortic valve disease (AVD) and mitral valve disease (MVD) by disease severity on direct health-care costs to insurers and patients. Materials and methods Based on 1996–2011 data from the Medical Expenditure Panel Survey (MEPS), a large, nationally representative US database, multivariate analyses were performed to assess the relationship between AVD and MVD and direct annual health-care costs to insurers and patients, at individual and US-aggregate levels. Adults aged 18 years and over with diagnosis codes for AVD or MVD based on International Classification of Diseases (ninth revision) diagnosis codes were identified. Subjects were further classified as symptomatic AVD, asymptomatic AVD, symptomatic MVD, and asymptomatic MVD. These classifications were determined with clinical assistance and based in part on data availability in the MEPS. Results The MEPS database included 148 patients with AVD: 53 patients with symptomatic AVD, 95 patients with asymptomatic AVD, and 1,051 with MVD, including 315 patients with symptomatic MVD and 736 patients with asymptomatic MVD. Symptomatic AVD had the largest incremental effect on annual per patient health-care expenditure: $12,789 for symptomatic AVD, $10,816 for asymptomatic AVD, $5,163 for symptomatic MVD, and $1,755 for asymptomatic MVD. When aggregated to the US population, heart-valve disease accounted for an incremental annual cost of $23.4 billion. The largest aggregate annual costs were incurred by patients with symptomatic MVD ($7.6 billion), followed by symptomatic AVD ($5.6 billion), asymptomatic MVD ($5.6 billion), and asymptomatic AVD ($4.6 billion). Conclusion The annualized incremental costs of heart-valve disease were substantial for all groups examined, and greatest for patients with symptomatic MVD. This reflects the relatively high prevalence associated with this group. With a growing and aging population, the prevalence of heart-valve disease is

  2. The direct health-care burden of valvular heart disease: evidence from US national survey data.

    PubMed

    Moore, Matt; Chen, Jie; Mallow, Peter J; Rizzo, John A

    2016-01-01

    This study quantified the overall effects of aortic valve disease (AVD) and mitral valve disease (MVD) by disease severity on direct health-care costs to insurers and patients. Based on 1996-2011 data from the Medical Expenditure Panel Survey (MEPS), a large, nationally representative US database, multivariate analyses were performed to assess the relationship between AVD and MVD and direct annual health-care costs to insurers and patients, at individual and US-aggregate levels. Adults aged 18 years and over with diagnosis codes for AVD or MVD based on International Classification of Diseases (ninth revision) diagnosis codes were identified. Subjects were further classified as symptomatic AVD, asymptomatic AVD, symptomatic MVD, and asymptomatic MVD. These classifications were determined with clinical assistance and based in part on data availability in the MEPS. The MEPS database included 148 patients with AVD: 53 patients with symptomatic AVD, 95 patients with asymptomatic AVD, and 1,051 with MVD, including 315 patients with symptomatic MVD and 736 patients with asymptomatic MVD. Symptomatic AVD had the largest incremental effect on annual per patient health-care expenditure: $12,789 for symptomatic AVD, $10,816 for asymptomatic AVD, $5,163 for symptomatic MVD, and $1,755 for asymptomatic MVD. When aggregated to the US population, heart-valve disease accounted for an incremental annual cost of $23.4 billion. The largest aggregate annual costs were incurred by patients with symptomatic MVD ($7.6 billion), followed by symptomatic AVD ($5.6 billion), asymptomatic MVD ($5.6 billion), and asymptomatic AVD ($4.6 billion). The annualized incremental costs of heart-valve disease were substantial for all groups examined, and greatest for patients with symptomatic MVD. This reflects the relatively high prevalence associated with this group. With a growing and aging population, the prevalence of heart-valve disease is expected to rise, increasing the burden on public health.

  3. Intraoperative Neuromonitoring and Alarm Criteria for Judging MEP Responses to Transcranial Electric Stimulation: The Threshold-Level Method.

    PubMed

    Calancie, Blair

    2017-01-01

    The motor evoked potential (MEP) is used in the operating room to gauge-and ultimately protect-the functional integrity of the corticospinal tract (CST). However, there is no consensus as to how to best interpret the MEP for maximizing its sensitivity and specificity to CST compromise. The most common way is to use criteria associated with response magnitude (response amplitude; waveform complexity, etc.). With this approach, should an MEP in response to a fixed stimulus intensity diminish below some predetermined cutoff, suggesting CST dysfunction, then the surgical team is warned. An alternative approach is to examine the minimum stimulus energy-the threshold-needed to elicit a minimal response from a given target muscle. Threshold increases could then be used as an alternative basis for evaluating CST functional integrity. As the original proponent of this Threshold-Level alarm criteria for MEP monitoring during surgery, I have been asked to summarize the basis for this method. In so doing, I have included justification for what might seem to be arbitrary recommendations. Special emphasis is placed on anesthetic considerations because these issues are especially important when weak stimulus intensities are called for. Finally, it is important to emphasize that all the alarm criteria currently in use for interpreting intraoperative MEPs have been shown to be effective for protecting CST axons during surgery. Although differences between approaches are more than academic, overall it is much better for patient welfare to be using some form of MEP monitoring than to use none at all, while you wait for consensus about alarm criteria to emerge.

  4. The Correlation Between Recordable MEPs and Motor Function During Spinal Surgery for Resection of Thoracic Spinal Cord Tumor.

    PubMed

    Guo, LanJun; Li, Yan; Han, Ruquan; Gelb, Adrian W

    2016-11-15

    Motor evoked potentials (MEPs) are commonly used during surgery for spinal cord tumor resection. However, it can be difficult to record reliable MEPs from the muscles of the lower extremities during surgery in patients with preoperative weakness due to spinal cord compression. In this study, motor function of patients' lower extremities and their association with intraoperative MEP recording were compared. Patients undergoing thoracic spinal cord tumor resection were studied. Patients' motor function was checked immediately before the surgical procedure. MEP responses were recorded from the tibialis anterior and foot muscles, and the hand muscles were used as control. Electrical current with train of eight pulses, 200 to 500 V was delivered through 2 corkscrews placed at C3' and C4' sites. Anesthesia was maintained by total intravenous anesthesia using a combination of propofol and remifentanil after induction with intravenous propofol, remifentanil, and rocuronium. Rocuronium was not repeated. Bispectral Index was maintained between 40 to 50. From 178 lower limbs of 89 patients, myogenic MEPs could be recorded from 100% (105/105) of the patients with 5 of 5 motor strength in lower extremity; 90% (36/40) from the patients with 4/5 motor strength; only 25% (5/20) with 3/5; and 12.5% (1/8) with 2/5 motor strength; none (0/5) were able to be recorded if the motor strength was 1/5. The ability to record myogenic MEPs is closely associated with the patient's motor function. They are difficult to obtain if motor function is 3/5 motor strength in the lower extremity. They are almost impossible to record if motor function is worse than 3/5.

  5. Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome.

    PubMed

    Lam, Uyen D P; Lerchbaum, Elisabeth; Schweighofer, Natascha; Trummer, Olivia; Eberhard, Katharina; Genser, Bernd; Pieber, Thomas R; Obermayer-Pietsch, Barbara

    2014-03-10

    Polycystic ovary syndrome (PCOS) shows not only hyperandrogenemia, hirsutism and fertility problems, but also metabolic disturbances including obesity, cardiovascular events and type-2 diabetes. Accumulating evidence suggests some degree of inflammation associated with prominent aspects of PCOS. We aimed to investigate the association of genetic variants 3'UTR rs17468190 (G/T) of the inflammation-associated gene MEP1A (GenBank ID: NM_005588.2) with metabolic disturbances in PCOS and healthy control women. Genetic variants rs17468190 (G/T) of MEP1A gene were analyzed in 576 PCOS women and 206 controls by using the Taqman fluorogenic 5'-exonuclease assay. This polymorphism was tested for association with anthropometric, metabolic, hormonal, and functional parameters of PCOS. There was a borderline significant difference in genotype distribution between PCOS and control women (p=0.046). In overweight/obese PCOS patients, the variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism. In a dominant model, the GG genotype of the MEP1A gene was more strongly associated with insulin metabolism in overweight/obese PCOS women (body mass index, BMI>25 kg/m(2)), than in GT+TT genotypes. The MEP1A GG-carriers showed a significantly increased homeostatic model assessment - insulin resistance (HOMA-IR) (p=0.003), elevation of fasting insulin (p=0.004) and stimulated insulin (30 min, p<0.001; 60 min, p=0.009; 120 min, p=0.009) as well as triglyceride (p=0.032) levels. MEP1A is a possible target gene for disease modification in PCOS. It might contribute to the abnormalities of glucose metabolism and insulin sensitivity and serve as a diagnostic or therapeutic target gene for PCOS.

  6. Heat exchanger panel

    NASA Technical Reports Server (NTRS)

    Warburton, Robert E. (Inventor); Cuva, William J. (Inventor)

    2005-01-01

    The present invention relates to a heat exchanger panel which has broad utility in high temperature environments. The heat exchanger panel has a first panel, a second panel, and at least one fluid containment device positioned intermediate the first and second panels. At least one of the first panel and the second panel have at least one feature on an interior surface to accommodate the at least one fluid containment device. In a preferred embodiment, each of the first and second panels is formed from a high conductivity, high temperature composite material. Also, in a preferred embodiment, the first and second panels are joined together by one or more composite fasteners.

  7. Response problems in a vacation panel study

    Treesearch

    Christine A. Vogt; Susan I. Stewart

    2001-01-01

    This paper investigates response problems encountered in a panel study of travel behavior. Though the overall response rate to the three-wave panel study was acceptable (over 60%), three types of response problems were encountered: refusal, non-response, and attrition. In a follow-up phone survey, a sample of individuals from each problem response group was questioned...

  8. Microcomputer Materials from MEP. An Annotated Directory of Packages of Interest to Further Education. An Occasional Paper.

    ERIC Educational Resources Information Center

    Gilbert, Leslie

    Designed to disseminate information to the post-school sector of United Kingdom education, this directory provides information on 50 microcomputer software packages developed by the Microelectronics Education Program (MEP) and available through educational publishers. Subject areas represented include accountancy, biology, business education,…

  9. The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein.

    PubMed

    Boeckstaens, Mélanie; Llinares, Elisa; Van Vooren, Pascale; Marini, Anna Maria

    2014-01-01

    The TORC1 complex controls cell growth upon integrating nutritional signals including amino-acid availability. TORC1 notably adapts the plasma membrane protein content by regulating arrestin-mediated endocytosis of amino-acid transporters. Here we demonstrate that TORC1 further fine tunes the inherent activity of the ammonium transport protein, Mep2, a yeast homologue of mammalian Rhesus factors, independently of arrestin-mediated endocytosis. The TORC1 effector kinase Npr1 and the upstream TORC1 regulator Npr2 control Mep2 transport activity by phospho-silencing a carboxy-terminal autoinhibitory domain. Under poor nitrogen supply, Npr1 enables Mep2 S457 phosphorylation and thus ammonium transport activity. Supplementation of the preferred nitrogen source glutamine leads to Mep2 inactivation and instant S457 dephosphorylation via plasma membrane Psr1 and Psr2 redundant phosphatases. This study underscores that TORC1 also adjusts nutrient permeability to regulate cell growth in a fast and flexible response to environmental perturbation, establishing a hierarchy in the transporters to be degraded, inactivated or maintained active at the plasma membrane.

  10. Potential effects of Trachyspermum copticum essential oil and propolis alcoholic extract on Mep3 gene expression of Microsporum canis isolates.

    PubMed

    Khosravi, A R; Shokri, H; Sohrabi, N

    2014-09-01

    The purpose of this study was to evaluate the effects of Trachyspermum copticum (T. copticum) essential oil and propolis alcoholic extract on growth and transcription of Mep3 gene of Microsporum canis (M. canis) strains. The antifungal activity was assayed by broth macrodilution method. Fungal isolates were grown in soy peptone liquid medium and treated with T. copticum oil and propolis extract. Total RNAs of M. canis were subjected to reverse transcription-polymerase chain reaction (RT-PCR). Specific primers of Actin and Mep3 genes were used. The results revealed that MIC values of T. copticum oil against M. canis strains were ranged from 0.2-30.5 μg/mL, with 42.3% of the strains inhibited at 0.9 μg/mL. In addition, MIC values of propolis extract against M. canis strains were ranged from 0.2-488.2 μg/mL, with 34.6% of the strains inhibited at 0.9 μg/mL. RT-PCR analysis of Mep3 and Actin expression showed DNA fragments of 661 and 690 bp amplified in all isolates before treatments with T. copticum essential oil and propolis extract. Both T. copticum and propolis completely inhibited the expression of Mep3 gene. We reported for the first time that T. copticum and propolis inhibits the expression of Mep3 gene in M. canis strains in relation to a remarkable inhibition in protease production by the fungus. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  11. Does transcranial stimulation for motor evoked potentials (TcMEP) worsen seizures in epileptic patients following spinal deformity surgery?

    PubMed

    Salem, Khalid M I; Goodger, Laura; Bowyer, Katherine; Shafafy, Masood; Grevitt, Michael P

    2016-10-01

    To investigate the effect of Transcranial Motor Evoked Potentials (TcMEP) in increasing the severity or frequency of post-operative seizures in patients undergoing deformity corrective spine surgery with a known history of seizures pre-operatively. The information on all patients with history of epilepsy/seizures who underwent spinal TcMEP cord monitoring for deformity correction surgery was retrospectively collected through a review of the hospital notes. The benefits of TcMEP in the early detection of potential cord ischemia were deemed by the operating surgeon to outweigh the increased risks of seizures, tongue biting, etc. Data on age, gender, pre-operative diagnosis, curve type, intra-operative monitoring alerts, duration of hospital stay, and post-operative in-hospital seizures were collected. Additionally, the patients were contacted following discharge and data on any change in the frequency of the seizures or an alteration in seizure-related medication post-operatively was also collected. The records of 449 consecutively monitored patients were reviewed and 12 (2.7 %) patients with a history of seizures pre-operatively were identified. The mean age was 23 (9-59) years, 7 females, 11 scoliosis corrections (4 neuromuscular, 1 degenerative, 6 idiopathic adolescent), and one sagittal balance correction surgery. Intra-operatively, all patients had TcMEP monitoring, were catheterised, and had no neuromonitoring alerts or record of tongue biting or laceration. Post-operatively, the mean hospital stay was 12 (4-25) days with no recorded seizures. At a mean of 23 (12-49) months post-discharge, none of the patients reported a worsening of seizures (pattern or frequency) or required an alteration in the seizure-related medications. TcMEP does not appear to trigger intra-operative or post-operative seizures and is not associated with deterioration in the seizure control of patients suffering seizures pre-operatively.

  12. Spatial Structure and Climatic Adaptation in African Maize Revealed by Surveying SNP Diversity in Relation to Global Breeding and Landrace Panels

    PubMed Central

    Westengen, Ola T.; Berg, Paul R.; Kent, Matthew P.; Brysting, Anne K.

    2012-01-01

    Background Climate change threatens maize productivity in sub-Saharan Africa. To ensure food security, access to locally adapted genetic resources and varieties is an important adaptation measure. Most of the maize grown in Africa is a genetic mix of varieties introduced at different historic times following the birth of the trans-Atlantic economy, and knowledge about geographic structure and local adaptations is limited. Methodology A panel of 48 accessions of maize representing various introduction routes and sources of historic and recent germplasm introductions in Africa was genotyped with the MaizeSNP50 array. Spatial genetic structure and genetic relationships in the African panel were analysed separately and in the context of a panel of 265 inbred lines representing global breeding material (based on 26,900 SNPs) and a panel of 1127 landraces from the Americas (270 SNPs). Environmental association analysis was used to detect SNPs associated with three climatic variables based on the full 43,963 SNP dataset. Conclusions The genetic structure is consistent between subsets of the data and the markers are well suited for resolving relationships and admixture among the accessions. The African accessions are structured in three clusters reflecting historical and current patterns of gene flow from the New World and within Africa. The Sahelian cluster reflects original introductions of Meso-American landraces via Europe and a modern introduction of temperate breeding material. The Western cluster reflects introduction of Coastal Brazilian landraces, as well as a Northeast-West spread of maize through Arabic trade routes across the continent. The Eastern cluster most strongly reflects gene flow from modern introduced tropical varieties. Controlling for population history in a linear model, we identify 79 SNPs associated with maximum temperature during the growing season. The associations located in genes of known importance for abiotic stress tolerance are

  13. Molecular structure, vibrational, HOMO-LUMO, MEP and NBO analysis of hafnium selenite

    NASA Astrophysics Data System (ADS)

    Yankova, Rumyana; Genieva, Svetlana; Dimitrova, Ginka

    2017-08-01

    In hydrothermal condition hafnium selenite with estimated chemical composition Hf(SeO3)2·n(H2O) was obtained and characterized by powder X-Ray diffraction, IR spectroscopy and thermogravimetrical analysis. The composition of the obtained crystalline phase was established as dihydrate of tetraaqua complex of the hafnium selenite [Hf(SeO3)2(H2O)4]·2H2O. The results of the thermogravimetrical analysis are shown that the two hydrated water molecules are released in the temperature interval 80-110°C, while the four coordinated water molecules - at 210-300°C. By DFT method, with Becke's three parameter exchange-functional combined with gradient-corrected correlation functional of Lee, Yang and Parr and 6-31G(d), 6-311 + G(d,p) basis sets and LANL2DZ for Hf atom were calculated the molecular structure, vibrational frequencies and thermodynamic properties of the structure. The UV-Vis spectra and electronic properties are presented. The energy and oscillator strength calculated by time-dependent density functional theory corresponds well with the experimental ones. Molecular electrostatic potential (MEP) was performed. Mulliken population analysis on atomic charges was also calculated. The stability and intramolecular interactions are interpreted by NBO analysis.

  14. A Chemical Rescue Screen Identifies a Plasmodium falciparum Apicoplast Inhibitor Targeting MEP Isoprenoid Precursor Biosynthesis

    PubMed Central

    Wu, Wesley; Herrera, Zachary; Ebert, Danny; Baska, Katie; Cho, Seok H.

    2014-01-01

    The apicoplast is an essential plastid organelle found in Plasmodium parasites which contains several clinically validated antimalarial-drug targets. A chemical rescue screen identified MMV-08138 from the “Malaria Box” library of growth-inhibitory antimalarial compounds as having specific activity against the apicoplast. MMV-08138 inhibition of blood-stage Plasmodium falciparum growth is stereospecific and potent, with the most active diastereomer demonstrating a 50% effective concentration (EC50) of 110 nM. Whole-genome sequencing of 3 drug-resistant parasite populations from two independent selections revealed E688Q and L244I mutations in P. falciparum IspD, an enzyme in the MEP (methyl-d-erythritol-4-phosphate) isoprenoid precursor biosynthesis pathway in the apicoplast. The active diastereomer of MMV-08138 directly inhibited PfIspD activity in vitro with a 50% inhibitory concentration (IC50) of 7.0 nM. MMV-08138 is the first PfIspD inhibitor to be identified and, together with heterologously expressed PfIspD, provides the foundation for further development of this promising antimalarial drug candidate lead. Furthermore, this report validates the use of the apicoplast chemical rescue screen coupled with target elucidation as a discovery tool to identify specific apicoplast-targeting compounds with new mechanisms of action. PMID:25367906

  15. Survey of the World Agricultural Documentation Services, Draft; Prepared on Behalf of the FAO Panel of Experts on "AGRIS" (International Information System for the Agricultural Sciences and Technology).

    ERIC Educational Resources Information Center

    Buntrock, H.

    The purpose of the survey was: (1) to evaluate existing agricultural information services and (2) to propose possible frameworks for an improved world-wide agricultural information service. The principal statistical results of the survey are summarized in the following figures which are based on data collected in nearly all instances for the year…

  16. A TGFβ-PRMT5-MEP50 Axis Regulates Cancer Cell Invasion through Histone H3 and H4 Arginine Methylation Coupled Transcriptional Activation and Repression

    PubMed Central

    Chen, Hongshan; Lorton, Benjamin; Gupta, Varun; Shechter, David

    2016-01-01

    Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human tumors. We demonstrate that PRMT5-MEP50 is essential for transcriptional regulation promoting cancer cell invasive phenotypes in lung adenocarcinoma, lung squamous cell carcinoma and breast carcinoma cancer cells. RNA-Seq transcriptome analysis demonstrated that PRMT5 and MEP50 are required to maintain expression of metastasis and Epithelial-to-mesenchymal transition (EMT) markers and to potentiate an epigenetic mechanism of the TGFβ response. We show that PRMT5-MEP50 activity both positively and negatively regulates expression of a wide range of genes. Exogenous TGFβ promotes EMT in a unique pathway of PRMT5-MEP50 catalyzed histone mono- and dimethylation of chromatin at key metastasis suppressor and EMT genes, defining a new mechanism regulating cancer invasivity. PRMT5 methylation of histone H3R2me1 induced transcriptional activation by recruitment of WDR5 and concomitant H3K4 methylation at targeted genes. In parallel, PRMT5 methylation of histone H4R3me2s suppressed transcription at distinct genomic loci. Our decoding of histone methylarginine at key genes supports a critical role for complementary PRMT5-MEP50 transcriptional activation and repression in cancer invasion pathways and in response to TGFβ stimulation and therefore and orients future chemotherapeutic opportunities. PMID:27270440

  17. Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters.

    PubMed

    Marini, Anna Maria; Boeckstaens, Mélanie; Benjelloun, Fatine; Chérif-Zahar, Baya; André, Bruno

    2006-06-01

    Ammonium transport proteins belonging to the Mep/Amt/Rh family are spread throughout all domains of life. A conserved aspartate residue plays a key role in the function of Escherichia coli AmtB. Here, we show that the analogous aspartate residue is critical for the transport function of eukaryotic family members as distant as the yeast transporter/sensor Mep2 and the human RhAG and RhCG proteins. In yeast Mep2, replacement of aspartate(186) with asparagine produced an inactive transporter localized at the cell surface, whilst replacement with alanine was accompanied by stacking of the protein in the endoplasmic reticulum. Introduction of an acidic residue, glutamate, produced a partially active protein. A carboxyl group at position 186 of Mep2 therefore appears mandatory for function. Kinetic analysis shows the Mep2(D186E) variant to be particularly affected at the level of substrate affinity, suggesting an involvement of aspartate(186) in ammonium recognition. Our data also put forward that ammonium recognition and/or transport by Mep2 is required for the sensor role played in the development of pseudohyphal growth. Finally, replacement of the conserved aspartate with asparagine in human RhAG and RhCG proteins resulted in the loss of bi-directional transport function. Hence, this aspartate residue might play a preserved functional role in Mep/Amt/Rh proteins.

  18. Differences in health services utilization and costs between antihypertensive medication users versus nonusers in adults with diabetes and concomitant hypertension from Medical Expenditure Panel Survey pooled years 2006 to 2009.

    PubMed

    Davis-Ajami, Mary Lynn; Wu, Jun; Fink, Jeffrey C

    2014-01-01

    To compare population-level baseline characteristics, individual-level utilization, and costs between antihypertensive medication users versus nonusers in adults with diabetes and concomitant hypertension. This longitudinal retrospective observational research used Medical Expenditure Panel Survey household component pooled years 2006 to 2009 to analyze adults 18 years or older with nongestational diabetes and coexistent essential hypertension. Two groups were created: 1) antihypertensive medication users and 2) no antihypertensive pharmacotherapy. We examined average annualized health care costs and emergency department and hospital utilization. Accounting for Medical Expenditure Panel Survey's complex survey design, all analyses used longitudinal weights. Logistic regressions examined the likelihood of utilization and anytihypertensive medication use, and log-transformed multiple linear regression models assessed costs and antihypertensive medication use. Of the 3261 adults identified with diabetes, 66% (n = 2137) had concomitant hypertension representing 38.7 million individuals during 2006 to 2009. Significantly, the 16% (n = 338) no antihypertensive pharmacotherapy group showed greater mean nights hospitalized (3.6 vs. 1.7, P = 0.0120), greater all-cause hospitalization events per 1000 patient months (41 vs. 24, P = 0.0.007), and lower mean diabetes-related and hypertension-related ambulatory visits. After adjusting for confounders, non-antihypertensive medication users showed 1.64 odds of hospitalization, 29% lower total, and 27% lower average annualized medical expenses compared with antihypertensive medication users. In adults with diabetes and coexistent hypertension, we observed significantly greater hospitalizations and lower costs for the non antihypertensive pharmacotherapy group versus those using antihypertensive medications. The short-term time horizon greater hospitalizations with lower expenses among non-antihypertensive medication users with

  19. Quality Indicators for Continuous Monitoring to Improve Maternal and Infant Health in Maternity Departments: A Modified Delphi Survey of an International Multidisciplinary Panel

    PubMed Central

    Boulkedid, Rym; Sibony, Olivier; Goffinet, François; Fauconnier, Arnaud; Branger, Bernard; Alberti, Corinne

    2013-01-01

    Objective Measuring the quality of inpatient obstetrical care using quality indicators is becoming increasingly important for both patients and healthcare providers. However, there is no consensus about which measures are optimal. We describe a modified Delphi method to identify a set of indicators for continuously monitoring the quality of maternity care by healthcare professionals. Methodology and Main Findings An international French-speaking multidisciplinary panel comprising 22 obstetricians-gynaecologists, 12 midwives, and 1 paediatrician assessed potential indicators extracted from a medical literature search, using a two-round Delphi procedure followed by a physical meeting. Each panellist rated each indicator based on validity and feasibility. In the first round, 35 panellists from 5 countries and 20 maternity units evaluated 26 indicators including 15 related to the management of the overall population of pregnant women, 3 to the management of women followed from the first trimester of pregnancy, 2 to the management of low-risk pregnant women, and 6 to the management of neonates. 25 quality indicators were kept for next step. In the second round, 27 (27/35: 77%) panellists selected 17 indicators; the remaining 8 indicators were discussed during a physical meeting. The final set comprised 18 indicators. Conclusion A multidisciplinary panel selected indicators that reflect the quality of obstetrical care. This set of indicators could be used to assess and monitor obstetrical care, with the goal of improving the quality of care in maternity units. PMID:23577143

  20. Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus.

    PubMed

    Han, Mei; Heppel, Simon C; Su, Tao; Bogs, Jochen; Zu, Yuangang; An, Zhigang; Rausch, Thomas

    2013-01-01

    In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this pathway in response to developmental and environmental cues and in response to specific enzyme inhibitors. For the MEP pathway entry enzyme 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a new (type I) DXS isoform, CrDXS1, has been cloned, which, in contrast to previous reports on type II CrDXS, was not transcriptionally activated by the transcription factor ORCA3. Regulation of the MEP pathway in response to metabolic perturbations has been explored using the enzyme inhibitors clomazone (precursor of 5-ketochlomazone, inhibitor of DXS) and fosmidomycin (inhibitor of deoxyxylulose 5-phosphate reductoisomerase (DXR)), respectively. Young leaves of non-flowering plants were exposed to both inhibitors, adopting a non-invasive in vivo technique. Transcripts and proteins of DXS (3 isoforms), DXR, and hydroxymethylbutenyl diphosphate synthase (HDS) were monitored, and protein stability was followed in isolated chloroplasts. Transcripts for DXS1 were repressed by both inhibitors, whereas transcripts for DXS2A&B, DXR and HDS increased after clomazone treatment but were barely affected by fosmidomycin treatment. DXS protein accumulated in response to both inhibitors, whereas DXR and HDS proteins were less affected. Fosmidomycin-induced accumulation of DXS protein indicated substantial posttranscriptional regulation. Furthermore, fosmidomycin effectively protected DXR against degradation in planta and in isolated chloroplasts. Thus our results suggest that DXR protein stability may be affected by substrate binding. In summary, the present results provide novel insight into the regulation of DXS expression in C. roseus in response to MEP-pathway perturbation.

  1. Enzyme Inhibitor Studies Reveal Complex Control of Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzyme Expression in Catharanthus roseus

    PubMed Central

    Han, Mei; Heppel, Simon C.; Su, Tao; Bogs, Jochen; Zu, Yuangang; An, Zhigang; Rausch, Thomas

    2013-01-01

    In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this pathway in response to developmental and environmental cues and in response to specific enzyme inhibitors. For the MEP pathway entry enzyme 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a new (type I) DXS isoform, CrDXS1, has been cloned, which, in contrast to previous reports on type II CrDXS, was not transcriptionally activated by the transcription factor ORCA3. Regulation of the MEP pathway in response to metabolic perturbations has been explored using the enzyme inhibitors clomazone (precursor of 5-ketochlomazone, inhibitor of DXS) and fosmidomycin (inhibitor of deoxyxylulose 5-phosphate reductoisomerase (DXR)), respectively. Young leaves of non-flowering plants were exposed to both inhibitors, adopting a non-invasive in vivo technique. Transcripts and proteins of DXS (3 isoforms), DXR, and hydroxymethylbutenyl diphosphate synthase (HDS) were monitored, and protein stability was followed in isolated chloroplasts. Transcripts for DXS1 were repressed by both inhibitors, whereas transcripts for DXS2A&B, DXR and HDS increased after clomazone treatment but were barely affected by fosmidomycin treatment. DXS protein accumulated in response to both inhibitors, whereas DXR and HDS proteins were less affected. Fosmidomycin-induced accumulation of DXS protein indicated substantial posttranscriptional regulation. Furthermore, fosmidomycin effectively protected DXR against degradation in planta and in isolated chloroplasts. Thus our results suggest that DXR protein stability may be affected by substrate binding. In summary, the present results provide novel insight into the regulation of DXS expression in C. roseus in response to MEP-pathway perturbation. PMID:23650515

  2. The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction.

    PubMed

    Khademi, Shahram; Stroud, Robert M

    2006-12-01

    The atomic structures of the first members of the Amt/MEP/Rh family show that they are 11-crossing membrane proteins that form trimers in the membrane. Each monomer supports a hydrophobic channel that conducts NH(3) but not any water or ions. The reprotonation of NH(3) on the receiving side raises the pH on that side in the absence of metabolism of NH(3), and there is no transfer of protons through the protein.

  3. Evidence that Fungal MEP Proteins Mediate Diffusion of the Uncharged Species NH3 across the Cytoplasmic Membrane

    PubMed Central

    Soupene, Eric; Ramirez, Robert M.; Kustu, Sydney

    2001-01-01

    Methylammonium and ammonium (MEP) permeases of Saccharomyces cerevisiae belong to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+ + NH3). Transport and accumulation of the ammonium analog [14C]methylammonium, a weak base, led to the proposal that members of this family were capable of energy-dependent concentration of the ammonium ion, NH4+. In bacteria, however, ATP-dependent conversion of methylammonium to γ-N-methylglutamine by glutamine synthetase precludes its use in assessing concentrative transport across the cytoplasmic membrane. We have confirmed that methylammonium is not metabolized in the yeast S. cerevisiae and have shown that it is little metabolized in the filamentous fungus Neurospora crassa. However, its accumulation depends on the energy-dependent acidification of vacuoles. A Δvph1 mutant of S. cerevisiae and a Δvma1 mutant, which lack vacuolar H+-ATPase activity, had large (fivefold or greater) defects in the accumulation of methylammonium, with little accompanying defect in the initial rate of transport. A vma-1 mutant of N. crassa largely metabolized methylammonium to methylglutamine. Thus, in fungi as in bacteria, subsequent energy-dependent utilization of methylammonium precludes its use in assessing active transport across the cytoplasmic membrane. The requirement for a proton gradient to sequester the charged species CH3NH3+ in acidic vacuoles provides evidence that the substrate for MEP proteins is the uncharged species CH3NH2. By inference, their natural substrate is NH3, a gas. We postulate that MEP proteins facilitate diffusion of NH3 across the cytoplasmic membrane and speculate that human Rhesus proteins, which lie in the same domain family as MEP proteins, facilitate diffusion of CO2. PMID:11486013

  4. Estimation of own and cross price elasticities of alcohol demand in the UK--A pseudo-panel approach using the Living Costs and Food Survey 2001-2009.

    PubMed

    Meng, Yang; Brennan, Alan; Purshouse, Robin; Hill-McManus, Daniel; Angus, Colin; Holmes, John; Meier, Petra Sylvia

    2014-03-01

    The estimation of price elasticities of alcohol demand is valuable for the appraisal of price-based policy interventions such as minimum unit pricing and taxation. This study applies a pseudo-panel approach to the cross-sectional Living Cost and Food Survey 2001/2-2009 to estimate the own- and cross-price elasticities of off- and on-trade beer, cider, wine, spirits and ready-to-drinks in the UK. A pseudo-panel with 72 subgroups defined by birth year, gender and socioeconomic status is constructed. Estimated own-price elasticities from the base case fixed effect models are all negative and mostly statically significant (p<0.05). Off-trade cider and beer are most elastic (-1.27 and -0.98) and off-trade spirits and on-trade ready-to-drinks are least elastic (-0.08 and -0.19). Estimated cross-price elasticities are smaller in magnitude with a mix of positive and negative signs. The results appear plausible and robust and could be used for appraising the estimated impact of price-based interventions in the UK. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Estimation of own and cross price elasticities of alcohol demand in the UK—A pseudo-panel approach using the Living Costs and Food Survey 2001–2009☆

    PubMed Central

    Meng, Yang; Brennan, Alan; Purshouse, Robin; Hill-McManus, Daniel; Angus, Colin; Holmes, John; Meier, Petra Sylvia

    2014-01-01

    The estimation of price elasticities of alcohol demand is valuable for the appraisal of price-based policy interventions such as minimum unit pricing and taxation. This study applies a pseudo-panel approach to the cross-sectional Living Cost and Food Survey 2001/2–2009 to estimate the own- and cross-price elasticities of off- and on-trade beer, cider, wine, spirits and ready-to-drinks in the UK. A pseudo-panel with 72 subgroups defined by birth year, gender and socioeconomic status is constructed. Estimated own-price elasticities from the base case fixed effect models are all negative and mostly statically significant (p < 0.05). Off-trade cider and beer are most elastic (−1.27 and −0.98) and off-trade spirits and on-trade ready-to-drinks are least elastic (−0.08 and −0.19). Estimated cross-price elasticities are smaller in magnitude with a mix of positive and negative signs. The results appear plausible and robust and could be used for appraising the estimated impact of price-based interventions in the UK. PMID:24508846

  6. Hepatitis virus panel

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/003558.htm Hepatitis virus panel To use the sharing features on this page, please enable JavaScript. The hepatitis virus panel is a series of blood tests used ...

  7. Significance of intraoperative motor function monitoring using transcranial electrical motor evoked potentials (MEP) in patients with spinal and cranial lesions near the motor pathways.

    PubMed

    Krammer, Matthias Johannes; Wolf, Stefan; Schul, David Baruch; Gerstner, Werner; Lumenta, Christianto Bernardo

    2009-02-01

    Intraoperative motor evoked potential (MEP) monitoring in patients with spinal and cranial lesions is thought to be a valuable tool for prevention of postoperative motor deficits. Aim of this study was to investigate its diagnostic value in a spinal and a cranial patient group. Ninety-six patients, 31 with spinal and 65 with intracranial lesions, were studied. Transcranial stimulation was performed with a high-frequency electrical train stimulation using two subdermal needle electrodes. MEPs were recorded from the pathology-related muscles. Decreasing amplitudes of 50% or more, increasing stimulus intensities of 20% or more or increased latencies were taken as warning criteria. MEP recording was possible in 90% of the spinal and 98% of the cranial group. With two further exclusions, 28 patients of the spinal and 62 of the cranial group were analyzed. We saw a temporary maximum amplitude reduction of 50% or more and an increase in stimulation intensity of 20% or more in 8 spinal and 29 cranial patients. Five of the spinal and nine of the cranial patients deteriorated in motor function postoperatively. One patient with normal MEP monitoring showed a temporary motor weakness postoperatively. Latencies were normal in all patients. Given both warning criteria, intraoperative MEP changes had a sensitivity of 83%/ 100% and a specificity of 86%/ 62% (spinal/ cranial group). The positive predictive value of MEP changes for postoperative motor function deterioration was 63%/ 31%, and the negative predictive value was 95%/ 100%. Transcranial electrical monitoring of MEP is a practicable and safe method. However, there are many events, which can cause amplitude changes of MEP independent from surgical manipulations. Although sensitivity is high for both groups, this results in a moderate specificity for the cranial group and a low positive predictive value for both groups.

  8. Advanced concentrator panels

    NASA Technical Reports Server (NTRS)

    Bell, D. M.; Bedard, R. J., Jr.

    1981-01-01

    The prototype fabrication of a lightweight, high-quality cellular glass substrate reflective panel for use in an advanced point-focusing solar concentrator was completed. The reflective panel is a gore shaped segment of an 11-m paraboloidal dish. The overall concentrator design and the design of the reflective panels are described. prototype-specific panel design modifications are discussed and the fabrication approach and procedure outlined.

  9. Computerisation in Public Libraries. A Report of the Survey Carried Out by the Technical Panel of the Association of London Chief Librarians during 1982.

    ERIC Educational Resources Information Center

    Association of London Chief Librarians (England).

    A survey of public library authorities located in the 34 London boroughs was conducted during the summer of 1982 to determine the characteristics and extent of library automation and to assess changes since a similar 1978/79 study. Replies were received from 33 authorities, of whom 30 reported using computerized techniques. Information on library…

  10. TRMM Solar Array Panels

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This final report presents conclusions/recommendations concerning the TRMM Solar Array; deliverable list and schedule summary; waivers and deviations; as-shipped performance data, including flight panel verification matrix, panel output detail, shadow test summary, humidity test summary, reverse bias test panel; and finally, quality assurance summary.

  11. Induction of apoptosis in HepG2 cells by polysaccharide MEP-II from the fermentation broth of Morchella esculenta.

    PubMed

    Hu, Meili; Chen, Yan; Wang, Cui; Cui, Huali; Duan, Peilu; Zhai, Tianlong; Yang, Yuling; Li, Shaofei

    2013-01-01

    A novel polysaccharide, MEP-II, isolated from the fermentation broth of Morchella esculenta inhibited the proliferation of human hepatoma cell line (HepG2) through an apoptotic pathway. After HepG2 cells were treated with 150-600 μg MEP-II/ml, typical apoptotic characteristics including externalization of phosphatidylserine residues on the cell surface, nuclear fragmentation, chromatin condensation and cytoplasm shrinkage were observed. Furthermore, reactive oxygen species (ROS) burst and the collapse of mitochondrial membrane potential (Δψm) also occurred in HepG2 cells after incubation of 150-600 μg MEP-II/ml. The antioxidant, 1 mM N-acetyl-L-cysteine inhibited MEP-II-induced apoptosis, suggesting that ROS are the key mediators for MEP-II-induced apoptosis. MEP-II is therefore a potential anti-tumor agent that induces apoptosis of HepG2 cells through ROS generation.

  12. Effect of volitional relaxation and motor imagery on F wave and MEP: do these tasks affect excitability of the spinal or cortical motor neurons?

    PubMed

    Fujisawa, R; Kimura, J; Taniguchi, S; Ichikawa, H; Hara, M; Shimizu, H; Iida, H; Yamada, T; Tani, T

    2011-07-01

    To test if simple motor imagery, like thumb abduction, preferentially influences the excitability of the spinal or cortical motoneurons. Ten healthy subjects underwent two separate experiments, each consisting of recording F waves and MEPs from abductor pollicis brevis (APB) in three consecutive sessions: (1) baseline, (2) after immobilizing APB for 3 h, and (3) after brief muscle exercise. During the immobilization, the subjects were instructed to volitionally relax APB in experiment 1 (relaxation task), and mentally simulate thumb abduction without actual movement in experiment 2 (imagery task). Relaxation task suppressed both MEPs and F waves. Motor imagery reduced this suppression, restoring F waves nearly completely (94%) and MEPs only partially (77%). Hence, the rest-induced decline of MEPs in part results from cortical modulation. In contrast, statistical analysis revealed no differences in imagery-induced recovery of motoneuron excitabilities whether assessed by F wave or MEP. Thus, increased excitability of spinal motoneurons responsible for F-wave changes also accounts for recovery of MEPs. Volitional relaxation depresses the spinal and cortical motoneurons, whereas mental simulation counters rest-induced suppression primarily by restoring spinal excitability. The present findings help elucidate physiologic mechanisms underlying motor imagery. Copyright © 2010 International Federation of Clinical Neurophysiology. All rights reserved.

  13. Cloning and characterization of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway genes of a natural-rubber producing plant, Hevea brasiliensis.

    PubMed

    Sando, Tomoki; Takeno, Shinya; Watanabe, Norie; Okumoto, Hiroshi; Kuzuyama, Tomohisa; Yamashita, Atsushi; Hattori, Masahira; Ogasawara, Naotake; Fukusaki, Eiichiro; Kobayashi, Akio

    2008-11-01

    Natural rubber is synthesized as rubber particles in the latex, the fluid cytoplasm of laticifers, of Hevea brasiliensis. Although it has been found that natural rubber is biosynthesized through the mevalonate pathway, the involvement of an alternative 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is uncertain. We obtained all series of the MEP pathway candidate genes by analyzing expressed sequence tag (EST) information and degenerate PCR in H. brasiliensis. Complementation experiments with Escherichia coli mutants were performed to confirm the functions of the MEP pathway gene products of H. brasiliensis together with those of Arabidopsis thaliana, and it was found that 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, and 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase of H. brasiliensis were functionally active in the E. coli mutants. Gene expression analysis revealed that the expression level of the HbDXS2 gene in latex was relatively high as compared to those of other MEP pathway genes. However, a feeding experiment with [1-(13)C] 1-deoxy-D-xylulose triacetate, an intermediate derivative of the MEP pathway, indicated that the MEP pathway is not involved in rubber biosynthesis, but is involved in carotenoids biosynthesis in H. brasiliensis.

  14. Peptidoglycan-associated outer membrane protein Mep45 of rumen anaerobe Selenomonas ruminantium forms a non-specific diffusion pore via its C-terminal transmembrane domain

    PubMed Central

    Kojima, Seiji; Hayashi, Kanako; Tochigi, Saeko; Kusano, Tomonobu; Kaneko, Jun; Kamio, Yoshiyuki

    2016-01-01

    The major outer membrane protein Mep45 of Selenomonas ruminantium, an anaerobic Gram-negative bacterium, comprises two distinct domains: the N-terminal S-layer homologous (SLH) domain that protrudes into the periplasm and binds to peptidoglycan, and the remaining C-terminal transmembrane domain, whose function has been unknown. Here, we solubilized and purified Mep45 and characterized its function using proteoliposomes reconstituted with Mep45. We found that Mep45 forms a nonspecific diffusion channel via its C-terminal region. The channel was permeable to solutes smaller than a molecular weight of roughly 600, and the estimated pore radius was 0.58 nm. Truncation of the SLH domain did not affect the channel property. On the basis of the fact that Mep45 is the most abundant outer membrane protein in S. ruminantium, we conclude that Mep45 serves as a main pathway through which small solutes diffuse across the outer membrane of this bacterium. PMID:27310312

  15. Safety Panel Resources

    NASA Technical Reports Server (NTRS)

    Stewart, Christine E.

    2008-01-01

    The goal of this paper is to explore what resources are potentially available to safety panels and to provide some guidance on how to utilize those resources. While the examples used in this paper will concentrate on the Flight Equipment and Reliability Review Panel (FESRRP) and Extravehicular Activity (EVA) hardware that have come through that panel, as well as resources at Johnson Space Center, the paper will address how this applies to safety panels in general, and where possible cite examples for other safety panels.

  16. Attendance of cultural events and involvement with the arts-impact evaluation on health and well-being from a Swiss household panel survey.

    PubMed

    Węziak-Białowolska, D

    2016-10-01

    Although there is strong uptake of active or passive engagement with the cultural and creative activities as determinants of individual health, well-being and social participation, few population studies report any causal influence on self-reported and physical health or life satisfaction from voluntary engagement with the arts (playing an instrument or singing, painting, sculpture) or passive cultural participation (attending the cinema, theatre, opera and exhibitions). This study set out to investigate any potential derived benefits to the Swiss population. The 2010 and 2013 waves of the Swiss Household Panel study were used for analysis. The data are representative for the Swiss population aged 14 years and older with respect to major demographic variables. Using longitudinal data, the strengths of the two approaches to evaluating causal inference were simultaneously applied: propensity score matching and difference-in-differences. Propensity score matching attempted to eliminate selection bias by conditioning on confounding variables. Difference-in-differences estimator was applied to remove unobserved fixed effects via intra-individual comparisons over time by comparing the trends in a matched treatment and control group. The study showed that voluntary cultural activity-of any type, passive or active-did not seem to have any causative influence on health and well-being. Results showed that long-term health and well-being did not improve significantly as a result of any specific activity in the cultural arena. The investigation provided little evidence to justify health promotion messages for involvement with the arts. Nevertheless, these findings do not contest that active or passive participation in cultural- and arts-related activities may be beneficial to health and well-being when guided by qualified therapists to treat specific health-related problems. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

  17. Development of Self-Management Indicators for Chronic Hepatitis B Patients on Antiviral Therapy: Results of a Chinese Delphi Panel Survey

    PubMed Central

    Kong, Ling-Na; Guo, Ying; Qin, Bo; Peng, Xin; Zhu, Wen-Fen

    2015-01-01

    Objective This study aimed to develop a set of indicators that could be used to measure and monitor the self-management performance for chronic hepatitis B (CHB) patients on antiviral therapy in China. Methods A two-round Delphi study via e-mail correspondence was conducted, with a group of 30 Chinese experts. The Delphi questionnaire consisted of 53 indicators identified from a literature review. Experts rated and scored the importance of indicators on a five-point Likert scale. Consensus was considered to be reached if a median score in the top tertile (4-5) and ≥80% of panel ratings in the top tertile (4-5) after Round 2. The included indicators were validated with a group of 106 CHB patients. Results The response rates for the first and second rounds were 90.9% (n=30) and 86.7% (n=26), respectively. Three new indicators were suggested in the first round. 55 indicators were included in the second round after modified. 45 (81.8%) indicators achieved on the level of consensus, all of which had an inter-quartile range of 1 or below. The final set included 4 domains and 45 indicators which were well accepted and understandable by CHB patients. Conclusion This Delphi study produced a set of 45 self-management indicators for CHB patients on antiviral therapy in China. These indicators could be used to measure and monitor the patients’ self-management performance, with the goal of improving the quality of life in this population. PMID:26327606

  18. Interactive optical panel

    DOEpatents

    Veligdan, James T.

    1995-10-03

    An interactive optical panel assembly 34 includes an optical panel 10 having a plurality of ribbon optical waveguides 12 stacked together with opposite ends thereof defining panel first and second faces 16, 18. A light source 20 provides an image beam 22 to the panel first face 16 for being channeled through the waveguides 12 and emitted from the panel second face 18 in the form of a viewable light image 24a. A remote device 38 produces a response beam 40 over a discrete selection area 36 of the panel second face 18 for being channeled through at least one of the waveguides 12 toward the panel first face 16. A light sensor 42,50 is disposed across a plurality of the waveguides 12 for detecting the response beam 40 therein for providing interactive capability.

  19. ICFA neutrino panel report

    NASA Astrophysics Data System (ADS)

    Long, K.

    2015-07-01

    In the summer of 2013 the International Committee on Future Accelerators (ICFA) established a Neutrino Panel with the mandate: "To promote international cooperation in the development of the accelerator-based neutrino-oscillation program and to promote international collaboration in the development of a neutrino factory as a future intense source of neutrinos for particle physics experiments." In its first year the Panel organised a series of regional Town Meetings to collect input from the community and to receive reports from the regional planning exercises. The Panel distilled its findings and presented them in a report to ICFA [1]. In this contribution the formation and composition of the Panel are presented together with a summary of the Panel's findings from the three Regional Town Meetings. The Panel's initial conclusions are then articulated and the steps that the Panel seeks to take are outlined.

  20. Interactive optical panel

    DOEpatents

    Veligdan, J.T.

    1995-10-03

    An interactive optical panel assembly includes an optical panel having a plurality of ribbon optical waveguides stacked together with opposite ends thereof defining panel first and second faces. A light source provides an image beam to the panel first face for being channeled through the waveguides and emitted from the panel second face in the form of a viewable light image. A remote device produces a response beam over a discrete selection area of the panel second face for being channeled through at least one of the waveguides toward the panel first face. A light sensor is disposed across a plurality of the waveguides for detecting the response beam therein for providing interactive capability. 10 figs.

  1. cisMEP: an integrated repository of genomic epigenetic profiles and cis-regulatory modules in Drosophila

    PubMed Central

    2014-01-01

    Background Cis-regulatory modules (CRMs), or the DNA sequences required for regulating gene expression, play the central role in biological researches on transcriptional regulation in metazoan species. Nowadays, the systematic understanding of CRMs still mainly resorts to computational methods due to the time-consuming and small-scale nature of experimental methods. But the accuracy and reliability of different CRM prediction tools are still unclear. Without comparative cross-analysis of the results and combinatorial consideration with extra experimental information, there is no easy way to assess the confidence of the predicted CRMs. This limits the genome-wide understanding of CRMs. Description It is known that transcription factor binding and epigenetic profiles tend to determine functions of CRMs in gene transcriptional regulation. Thus integration of the genome-wide epigenetic profiles with systematically predicted CRMs can greatly help researchers evaluate and decipher the prediction confidence and possible transcriptional regulatory functions of these potential CRMs. However, these data are still fragmentary in the literatures. Here we performed the computational genome-wide screening for potential CRMs using different prediction tools and constructed the pioneer database, cisMEP (cis-regulatory module epigenetic profile database), to integrate these computationally identified CRMs with genomic epigenetic profile data. cisMEP collects the literature-curated TFBS location data and nine genres of epigenetic data for assessing the confidence of these potential CRMs and deciphering the possible CRM functionality. Conclusions cisMEP aims to provide a user-friendly interface for researchers to assess the confidence of different potential CRMs and to understand the functions of CRMs through experimentally-identified epigenetic profiles. The deposited potential CRMs and experimental epigenetic profiles for confidence assessment provide experimentally testable

  2. Fair play doesn't matter: MEP modulation as a neurophysiological signature of status quo bias in economic interactions.

    PubMed

    Pisoni, Alberto; Lo Gerfo, Emanuele; Ottone, Stefania; Ponzano, Ferruccio; Zarri, Luca; Vergallito, Alessandra; Romero Lauro, Leonor Josefina

    2014-11-01

    Transcranial magnetic stimulation (TMS) studies show that watching others' movements enhances motor evoked potential (MEPs) amplitude of the muscles involved in the observed action (motor facilitation, MF). MF has been attributed to a mirror neuron system mediated mechanism, causing an excitability increment of primary motor cortex. It is still unclear whether the meaning an action assumes when performed in an interpersonal exchange context could affect MF. This study aims at exploring this issue by measuring MF induced by the observation of the same action coupled with opposite reward values (gain vs loss) in an economic game. Moreover, the interaction frame was manipulated by showing the same actions within different economic games, the Dictator Game (DG) and the Theft Game (TG). Both games involved two players: a Dictator/Thief and a receiver. Experimental participants played the game always as receivers whereas the Dictator/Thief roles were played by our confederates. In each game Dictator/Thief's choices were expressed by showing a grasping action of one of two cylinders, previously associated with fair/unfair choices. In the DG the dictator decides whether to share (gain condition) or not (no-gain condition) a sum of money with the receiver, while in TGs the thief decides whether to steal (loss condition) or not to steal (no-loss condition) it from the participants. While the experimental subjects watched the videos showing these movements, a single TMS pulse was delivered to their motor hand area and a MEP was recorded from the right FDI muscle. Results show that, in the DG, MF was enhanced by the status quo modification, i.e. MEP amplitude increased when the dictator decided to change the receivers' status quo and share his/her money, and this was true when the status quo was more salient. The same was true for the TG, where the reverse happened: MF was higher for trials in which the thief decided to steal the participants' money, thus changing the status

  3. Physiological function of IspE, a plastid MEP pathway gene for isoprenoid biosynthesis, in organelle biogenesis and cell morphogenesis in Nicotiana benthamiana.

    PubMed

    Ahn, Chang Sook; Pai, Hyun-Sook

    2008-03-01

    Isoprenoid biosynthesis in plants occurs by two independent pathways: the cytosolic mevalonate (MVA) pathway and the plastidic methylerythritol phosphate (MEP) pathway. In this study, we investigated the cellular effects of depletion of IspE, a protein involved in the MEP pathway, using virus-induced gene silencing (VIGS). The IspE gene is preferentially expressed in young tissues, and induced by light and methyl jasmonate. The GFP fusion protein of IspE was targeted to chloroplasts. Reduction of IspE expression by VIGS resulted in a severe leaf yellowing phenotype. At the cellular level, depletion of IspE severely affected chloroplast development, dramatically reducing both the number and size of chloroplasts. Interestingly, mitochondrial development was also impaired, suggesting a possibility that the plastidic MEP pathway contributes to mitochondrial isoprenoid biosynthesis in leaves. A deficiency in IspE activity decreased cellular levels of the metabolites produced by the MEP pathway, such as chlorophylls and carotenoids, and stimulated expression of some of the downstream MEP pathway genes, particularly IspF and IspG. Interestingly, the IspE VIGS lines had significantly increased numbers of cells of reduced size in all leaf layers, compared with TRV control and other VIGS lines for the MEP pathway genes. The increased cell division in the IspE VIGS lines was particularly pronounced in the abaxial epidermal layer, in which the over-proliferated cells bulged out of the plane, making the surface uneven. In addition, trichome numbers dramatically increased and the stomata size varied in the affected tissues. Our results show that IspE deficiency causes novel developmental phenotypes distinct from the phenotypes of other MEP pathway mutants, indicating that IspE may have an additional role in plant development besides its role in isoprenoid biosynthesis.

  4. Working Papers: Astronomy and Astrophysics Panel Reports

    NASA Technical Reports Server (NTRS)

    Bahcall, John N.; Beichman, Charles A.; Canizares, Claude; Cronin, James; Heeschen, David; Houck, James; Hunten, Donald; Mckee, Christopher F.; Noyes, Robert; Ostriker, Jeremiah P.

    1991-01-01

    The papers of the panels appointed by the Astronomy and Astrophysics survey Committee are compiled. These papers were advisory to the survey committee and represent the opinions of the members of each panel in the context of their individual charges. The following subject areas are covered: radio astronomy, infrared astronomy, optical/IR from ground, UV-optical from space, interferometry, high energy from space, particle astrophysics, theory and laboratory astrophysics, solar astronomy, planetary astronomy, computing and data processing, policy opportunities, benefits to the nation from astronomy and astrophysics, status of the profession, and science opportunities.

  5. Check-Testing of Manufacturer Self Reported Labeling Data& Compliance with MEPS

    SciTech Connect

    Zhou, Nan; Zhou, Nan; Zheng, Nina; Fridley, David; Wang, Ruohong; Egan, Christine

    2008-03-01

    China first adopted minimum energy performance standards (MEPS) in 1989. Today, there are standards for a wide range of domestic, commercial and selected industrial equipment. In 1999, China launched a voluntary endorsement label, which has grown to cover over 40 products including water-saving products. Further, in 2005, China started a mandatory energy information label that initially covered two products and in 2007 was extended to cover four products total including: air conditioners; household refrigerators; clothes washers; and unitary air conditioners. These programs have had an important impact in reducing the energy consumption of appliances in China. China has built up a strong infrastructure to develop and implement standards. Historically, however, the government's primary focus has been on the technical requirements for specifying efficiency performance. Less attention has been paid to monitoring and enforcement with a minimal commitment of resources and little expansion of administrative capacity in this area. Thus, market compliance with both mandatory standard and labeling programs has been questionable. Furthermore, actual energy savings have quite possibly been undermined as a result. The establishment of a regularized monitoring system for tracking compliance with the mandatory standard and energy information label programs in China is a major area for program improvement. Over the years, the Collaborative Labeling and Appliance Standards Program (CLASP) has partnered with several Chinese institutions to promote energy-efficient products in China. CLASP, together with its implementing partner Lawrence Berkeley National Laboratory (LBNL), has assisted China in developing and updating the above-mentioned standards and labeling programs. Because of the increasing need for the development of a monitoring system to track compliance with the standard, CLASP, with support from Japan's Ministry of Economy, Trade and Industry (METI) and the Institute of

  6. Titanium honeycomb panel testing

    NASA Technical Reports Server (NTRS)

    Richards, W. L.; Thompson, Randolph C.

    1991-01-01

    The paper describes the procedures of thermal mechanical tests carried out at the NASA Dryden Flight Research Facility on two tianium honeycomb wing panels bonded using liquid interface diffusion (LID) technique, and presents the results of these tests. The 58.4 cm square panels consisted of two 0.152-cm-thick Ti 6-2-4-2 face sheets LID-bonded to a 1.9-cm-thick honeycomb core, with bearing plates fastened to the perimeter of the upper and the lower panel surfaces. The panels were instrumented with sensors for measuring surface temperature, strain, and deflections to 315 C and 482 C. Thermal stress levels representative of those encountered during aerodynamic heating were produced by heating the upper panel surface and restraining all four edges. After more than 100 thermal cycles from room temperature to 315 C and 50 cycles from room temperature to 482 C, no significant structural degradation was detected in the panels.

  7. Titanium honeycomb panel testing

    NASA Astrophysics Data System (ADS)

    Richards, W. L.; Thompson, Randolph C.

    The paper describes the procedures of thermal mechanical tests carried out at the NASA Dryden Flight Research Facility on two tianium honeycomb wing panels bonded using liquid interface diffusion (LID) technique, and presents the results of these tests. The 58.4 cm square panels consisted of two 0.152-cm-thick Ti 6-2-4-2 face sheets LID-bonded to a 1.9-cm-thick honeycomb core, with bearing plates fastened to the perimeter of the upper and the lower panel surfaces. The panels were instrumented with sensors for measuring surface temperature, strain, and deflections to 315 C and 482 C. Thermal stress levels representative of those encountered during aerodynamic heating were produced by heating the upper panel surface and restraining all four edges. After more than 100 thermal cycles from room temperature to 315 C and 50 cycles from room temperature to 482 C, no significant structural degradation was detected in the panels.

  8. Titanium Honeycomb Panel Testing

    NASA Technical Reports Server (NTRS)

    Richards, W. Lance; Thompson, Randolph C.

    1996-01-01

    Thermal-mechanical tests were performed on a titanium honeycomb sandwich panel to experimentally validate the hypersonic wing panel concept and compare test data with analysis. Details of the test article, test fixture development, instrumentation, and test results are presented. After extensive testing to 900 deg. F, non-destructive evaluation of the panel has not detected any significant structural degradation caused by the applied thermal-mechanical loads.

  9. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report from the Aerospace Safety Advisory Panel (ASAP) contains findings, recommendations, and supporting material concerning safety issues with the space station program, the space shuttle program, aeronautics research, and other NASA programs. Section two presents findings and recommendations, section three presents supporting information, and appendices contain data about the panel membership, the NASA response to the March 1993 ASAP report, and a chronology of the panel's activities during the past year.

  10. FluoMEP: a new genotyping method combining the advantages of randomly amplified polymorphic DNA and amplified fragment length polymorphism.

    PubMed

    Chang, Alex; Liew, Woei Chang; Chuah, Aaron; Lim, Zijie; Lin, Qifeng; Orban, Laszlo

    2007-02-01

    PCR-based identification of differences between two unknown genomes often requires complex manipulation of the templates prior to amplification and/or gel electrophoretic separation of a large number of samples with manual methods. Here, we describe a new genotyping method, called fluorescent motif enhanced polymorphism (fluoMEP). The fluoMEP method is based on random amplified polymorphic DNA (RAPD) assay, but combines the advantages of the large collection of unlabelled 10mer primers (ca. 5000) from commercial sources and the power of the automated CE devices used for the detection of amplified fragment length polymorphism (AFLP) patterns. The link between these two components is provided by a fluorescently labeled "common primer" that is used in a two-primer PCR together with an unlabeled RAPD primer. By using the same "common primer" and a series of RAPD primers, DNA templates can be screened quickly and effectively for polymorphisms. Our manuscript describes the optimization of the method and its characterization on different templates. We demonstrate by using several different approaches that the addition of the "common primer" to the PCR changes the profile of amplified fragments, allowing for screening various parts of the genome with the same set of unlabeled primers. We also present an in silico analysis of the genomic localization of fragments amplified by a RAPD primer with two different "common primers" and alone.

  11. Solar reflection panels

    DOEpatents

    Diver, Jr., Richard B.; Grossman, James W.; Reshetnik, Michael

    2006-07-18

    A solar collector comprising a glass mirror, and a composite panel, wherein the back of the mirror is affixed to a front surface of the composite panel. The composite panel comprises a front sheet affixed to a surface of a core material, preferably a core material comprising a honeycomb structure, and a back sheet affixed to an opposite surface of the core material. The invention may further comprise a sealing strip, preferably comprising EPDM, positioned between the glass mirror and the front surface of the composite panel. The invention also is of methods of making such solar collectors.

  12. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and

  13. PANEL LIBRARY AND EDITOR

    NASA Technical Reports Server (NTRS)

    Raible, E.

    1994-01-01

    The Panel Library and Editor is a graphical user interface (GUI) builder for the Silicon Graphics IRIS workstation family. The toolkit creates "widgets" which can be manipulated by the user. Its appearance is similar to that of the X-Windows System. The Panel Library is written in C and is used by programmers writing user-friendly mouse-driven applications for the IRIS. GUIs built using the Panel Library consist of "actuators" and "panels." Actuators are buttons, dials, sliders, or other mouse-driven symbols. Panels are groups of actuators that occupy separate windows on the IRIS workstation. The application user can alter variables in the graphics program, or fire off functions with a click on a button. The evolution of data values can be tracked with meters and strip charts, and dialog boxes with text processing can be built. Panels can be stored as icons when not in use. The Panel Editor is a program used to interactively create and test panel library interfaces in a simple and efficient way. The Panel Editor itself uses a panel library interface, so all actions are mouse driven. Extensive context-sensitive on-line help is provided. Programmers can graphically create and test the user interface without writing a single line of code. Once an interface is judged satisfactory, the Panel Editor will dump it out as a file of C code that can be used in an application. The Panel Library (v9.8) and Editor (v1.1) are written in C-Language (63%) and Scheme, a dialect of LISP, (37%) for Silicon Graphics 4D series workstations running IRIX 3.2 or higher. Approximately 10Mb of disk space is required once compiled. 1.5Mb of main memory is required to execute the panel editor. This program is available on a .25 inch streaming magnetic tape cartridge in UNIX tar format for an IRIS, and includes a copy of XScheme, the public-domain Scheme interpreter used by the Panel Editor. The Panel Library Programmer's Manual is included on the distribution media. The Panel Library and

  14. Differential Contribution of the First Two Enzymes of the MEP Pathway to the Supply of Metabolic Precursors for Carotenoid and Chlorophyll Biosynthesis in Carrot (Daucus carota)

    PubMed Central

    Simpson, Kevin; Quiroz, Luis F.; Rodriguez-Concepción, Manuel; Stange, Claudia R.

    2016-01-01

    Carotenoids and chlorophylls are photosynthetic pigments synthesized in plastids from metabolic precursors provided by the methylerythritol 4-phosphate (MEP) pathway. The first two steps in the MEP pathway are catalyzed by the deoxyxylulose 5-phosphate synthase (DXS) and reductoisomerase (DXR) enzymes. While DXS has been recently shown to be the main flux-controlling step of the MEP pathway, both DXS and DXR enzymes have been proven to be able to promote an increase in MEP-derived products when overproduced in diverse plant systems. Carrot (Daucus carota) produces photosynthetic pigments (carotenoids and chlorophylls) in leaves and in light-exposed roots, whereas only carotenoids (mainly α- and β-carotene) accumulate in the storage root in darkness. To evaluate whether DXS and DXR activities influence the production of carotenoids and chlorophylls in carrot leaves and roots, the corresponding Arabidopsis thaliana genes were constitutively expressed in transgenic carrot plants. Our results suggest that DXS is limiting for the production of both carotenoids and chlorophylls in roots and leaves, whereas the regulatory role of DXR appeared to be minor. Interestingly, increased levels of DXS (but not of DXR) resulted in higher transcript abundance of endogenous carrot genes encoding phytoene synthase, the main rate-determining enzyme of the carotenoid pathway. These results support a central role for DXS on modulating the production of MEP-derived precursors to synthesize carotenoids and chlorophylls in carrot, confirming the pivotal relevance of this enzyme to engineer healthier, carotenoid-enriched products. PMID:27630663

  15. Change in psychological distress following change in workplace social capital: results from the panel surveys of the J-HOPE study.

    PubMed

    Tsuboya, Toru; Tsutsumi, Akizumi; Kawachi, Ichiro

    2015-03-01

    Research on the longitudinal association of workplace social capital and mental health is limited. The purpose of the present study was to investigate the prospective association of social capital in the workplace with mental distress, measured by K6, adjusting for individuals factors as well as workplace-related factors among employees in Japan. The participants included 6387 men and 1825 women from 12 private companies in Japan. Questionnaires, inquiring about workplace social capital, K6, job strain and effort-reward imbalance were administered at the baseline survey between October 2010 and December 2011 (response rate=77.4%). At 1-year follow-up, social capital and K6 were assessed again (follow-up rate=79.5%), and a generalised linear model was used to estimate the association between changes in workplace social capital and change in K6. After adjusting for baseline demographic characteristics and workplace-related factors (Job Content Questionnaire (JCQ), Effort-Reward Imbalance Questionnaire (ERIQ)), increased workplace social capital between waves was associated with improved psychological distress (β=-0.2327, p<0.0001). An inverse association was found in both men and women, all age groups, and among employees with high or low baseline mental health. The association was stronger among those who reported higher stress at baseline. Boosting workplace social capital may promote mental health in the workplace. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Associations Between E-Cigarette Type, Frequency of Use, and Quitting Smoking: Findings From a Longitudinal Online Panel Survey in Great Britain

    PubMed Central

    Brose, Leonie S.; Brown, Jamie; Robson, Debbie; McNeill, Ann

    2015-01-01

    Introduction: E-cigarettes can be categorized into two basic types, (1) cigalikes, that are disposable or use pre-filled cartridges and (2) tanks, that can be refilled with liquids. The aims of this study were to examine: (1) predictors of using the two e-cigarette types, and (2) the association between type used, frequency of use (daily vs. non-daily vs. no use), and quitting. Methods: Online longitudinal survey of smokers in Great Britain was first conducted in November 2012. Of 4064 respondents meeting inclusion criteria at baseline, this study included (N = 1643) current smokers followed-up 1 year later. Type and frequency of e-cigarette use were measured at follow-up. Results: At follow-up, 64% reported no e-cigarette use, 27% used cigalikes, and 9% used tanks. Among e-cigarette users at follow-up, respondents most likely to use tanks versus cigalikes included: 40–54 versus 18–24 year olds and those with low versus moderate/high education. Compared to no e-cigarette use at follow-up, non-daily cigalike users were less likely to have quit smoking since baseline (P = .0002), daily cigalike or non-daily tank users were no more or less likely to have quit (P = .3644 and P = .4216, respectively), and daily tank users were more likely to have quit (P = .0012). Conclusions: Whether e-cigarette use is associated with quitting depends on type and frequency of use. Compared with respondents not using e-cigarettes, daily tank users were more likely, and non-daily cigalike users were less likely, to have quit. Tanks were more likely to be used by older respondents and respondents with lower education. PMID:25896067

  17. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations

    PubMed Central

    van Hecke, Oliver; Kamerman, Peter R.; Attal, Nadine; Baron, Ralf; Bjornsdottir, Gyda; Bennett, David L.H.; Bennett, Michael I.; Bouhassira, Didier; Diatchenko, Luda; Freeman, Roy; Freynhagen, Rainer; Haanpää, Maija; Jensen, Troels S.; Raja, Srinivasa N.; Rice, Andrew S.C.; Seltzer, Ze'ev; Thorgeirsson, Thorgeir E.; Yarnitsky, David; Smith, Blair H.

    2015-01-01

    Abstract For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met with replication difficulties, in part because of differences in phenotypes used for case ascertainment. Because there is no consensus on the nature of these phenotypes, nor on the methods of collecting them, this study aimed to provide guidelines on collecting and reporting phenotypes in cases and controls for genetic studies. Consensus was achieved through a staged approach: (1) systematic literature review to identify all neuropathic pain phenotypes used in previous genetic studies; (2) Delphi survey to identify the most useful neuropathic pain phenotypes and their validity and feasibility; and (3) meeting of experts to reach consensus on the optimal phenotype(s) to be collected from patients with neuropathic pain for genetic studies. A basic “entry level” set of phenotypes was identified for any genetic study of neuropathic pain. This set identifies cases of “possible” neuropathic pain, and controls, and includes: (1) a validated symptom-based questionnaire to determine whether any pain is likely to be neuropathic; (2) body chart or checklist to identify whether the area of pain distribution is neuroanatomically logical; and (3) details of pain history (intensity, duration, any formal diagnosis). This NeuroPPIC “entry level” set of phenotypes can be expanded by more extensive and specific measures, as determined by scientific requirements and resource availability. PMID:26469320

  18. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

    PubMed

    van Hecke, Oliver; Kamerman, Peter R; Attal, Nadine; Baron, Ralf; Bjornsdottir, Gyda; Bennett, David L H; Bennett, Michael I; Bouhassira, Didier; Diatchenko, Luda; Freeman, Roy; Freynhagen, Rainer; Haanpää, Maija; Jensen, Troels S; Raja, Srinivasa N; Rice, Andrew S C; Seltzer, Zeʼev; Thorgeirsson, Thorgeir E; Yarnitsky, David; Smith, Blair H

    2015-11-01

    For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met with replication difficulties, in part because of differences in phenotypes used for case ascertainment. Because there is no consensus on the nature of these phenotypes, nor on the methods of collecting them, this study aimed to provide guidelines on collecting and reporting phenotypes in cases and controls for genetic studies. Consensus was achieved through a staged approach: (1) systematic literature review to identify all neuropathic pain phenotypes used in previous genetic studies; (2) Delphi survey to identify the most useful neuropathic pain phenotypes and their validity and feasibility; and (3) meeting of experts to reach consensus on the optimal phenotype(s) to be collected from patients with neuropathic pain for genetic studies. A basic "entry level" set of phenotypes was identified for any genetic study of neuropathic pain. This set identifies cases of "possible" neuropathic pain, and controls, and includes: (1) a validated symptom-based questionnaire to determine whether any pain is likely to be neuropathic; (2) body chart or checklist to identify whether the area of pain distribution is neuroanatomically logical; and (3) details of pain history (intensity, duration, any formal diagnosis). This NeuroPPIC "entry level" set of phenotypes can be expanded by more extensive and specific measures, as determined by scientific requirements and resource availability.

  19. Fabrication of prepackaged superalloy honeycomb Thermal Protection System (TPS) panels

    NASA Technical Reports Server (NTRS)

    Blair, W.; Meaney, J. E.; Rosenthal, H. A.

    1985-01-01

    High temperature materials were surveyed, and Inconel 617 and titanium were selected for application to a honeycomb TPS configuration designed to withstand 2000 F. The configuration was analyzed both thermally and structurally. Component and full-sized panels were fabricated and tested to obtain data for comparison with analysis. Results verified the panel design. Twenty five panels were delivered to NASA Langley Research Center for additional evaluation.

  20. Durability of structural panels

    Treesearch

    Eddie W. Price; [Editor

    1984-01-01

    Twenty papers from the proceedings of a workshop are presented on the durability of a group of structural panels for use in roof, wall, and floor sheathing applications. The panel types are waferboard,flakeboard, strandboard, oriented structural board, and structural particleboard. A summary of the proceedings is given as the final presentation.

  1. New mineral physics panels

    NASA Astrophysics Data System (ADS)

    The AGU Committee on Mineral Physics has formed itself into six panels. The committee chairman is Orson L. Anderson of the Department of Earth and Space Sciences, University of California, Los Angeles; foreign secretary is Robert Liebermann, Department of Earth and Space Sciences, State University of New York, Stony Brook. The six panels are as follows.

  2. Stereoscopic Flat Panel Display

    DTIC Science & Technology

    2004-12-01

    the display of stereo imagery have been demonstrated. Stereoscopic displays typically require the user to wear special headgear. Autostereoscopic ...components and the resulting changes in the encoding algorithm. Keywords: Stereoscopic display, LCD, 3D , polarization encoding, flat panel 1...panel display when viewing non-stereoscopic imagery or data. Remotely operated vehicles do not represent the only potential application for 3D

  3. SNP panels/Imputation

    USDA-ARS?s Scientific Manuscript database

    Participants from thirteen countries discussed services that Interbull can perform or recommendations that Interbull can make to promote harmonization and assist member countries in improving their genomic evaluations in regard to SNP panels and imputation. The panel recommended: A mechanism to shar...

  4. Flexible optical panel

    DOEpatents

    Veligdan, James T.

    2001-01-01

    A flexible optical panel includes laminated optical waveguides, each including a ribbon core laminated between cladding, with the core being resilient in the plane of the core for elastically accommodating differential movement thereof to permit winding of the panel in a coil.

  5. Reinventing the solar panel

    SciTech Connect

    Scanlon, M.

    1995-08-01

    This article discusses new technology in solar panels. PowerSource is a solar collector which not only is less expensive than conventional panels to purchase and install, but also increases the electrical output by almost 20%. This article describes the results of testing this system.

  6. Microgravity Science Research Panel

    NASA Technical Reports Server (NTRS)

    Carpenter, Bradley M.; Trinh, Eugene H.; DeLucas, Lawrence J.; Larson, David; Koss, Matthew; Ostrach, Simon

    2000-01-01

    This document is a transcription of the Microgravity Science Research Panel's discussion about their research and about some of the contributions that they feel have been important to the field during their time with the program. The panel includes Dr. Eugene Trinh, Dr. Lawrence DeLucas, Dr. Charles Bugg, Dr. David Larson, and Dr. Simon Ostrach.

  7. Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

    PubMed

    Masini, Tiziana; Hirsch, Anna K H

    2014-12-11

    Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2C-methyl-D-erythritol 4-phosphate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphate (2), the universal precursors of isoprenoids, while humans exclusively utilize the alternative mevalonate pathway for the synthesis of 1 and 2. This distinct distribution, together with the fact that the MEP pathway is essential in numerous organisms, makes the enzymes of the MEP pathway attractive drug targets for the development of anti-infective agents and herbicides. Herein, we review the inhibitors reported over the past 2 years, in the context of the most important older developments and with a particular focus on the results obtained against enzymes of pathogenic organisms. We will also discuss new discoveries in terms of structural and mechanistic features, which can help to guide a rational development of inhibitors.

  8. Conformational analysis, X-ray crystallographic, FT-IR, FT-Raman, DFT, MEP and molecular docking studies on 1-(1-(3-methoxyphenyl) ethylidene) thiosemicarbazide.

    PubMed

    Saravanan, R R; Seshadri, S; Gunasekaran, S; Mendoza-Meroño, R; Garcia-Granda, S

    2015-03-15

    Conformational analysis, X-ray crystallographic, FT-IR, FT-Raman, DFT, MEP and molecular docking studies on 1-(1-(3-methoxyphenyl) ethylidene) thiosemicarbazide (MPET) are investigated. From conformational analysis the examination of the positions of a molecule taken and the energy changes is observed. The docking studies of the ligand MPET with target protein showed that this is a good molecule which docks well with target related to HMG-CoA. Hence MPET can be considered for developing into a potent anti-cholesterol drug. MEP assists in optimization of electrostatic interactions between the protein and the ligand. The MEP surface displays the molecular shape, size and electrostatic potential values. The optimized geometry of the compound was calculated from the DFT-B3LYP gradient calculations employing 6-31G (d, p) basis set and calculated vibrational frequencies are evaluated via comparison with experimental values. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Panel 5: Microbiology and Immunology Panel

    PubMed Central

    Murphy, Timothy F.; Chonmaitree, Tasnee; Barenkamp, Stephen; Kyd, Jennelle; Nokso-Koivisto, Johanna; Patel, Janak A.; Heikkinen, Terho; Yamanaka, Noboru; Ogra, Pearay; Swords, W. Edward; Sih, Tania; Pettigrew, Melinda M.

    2014-01-01

    Objective The objective is to perform a comprehensive review of the literature from January 2007 through June 2011 on the virology, bacteriology, and immunology related to otitis media. Data Sources PubMed database of the National Library of Medicine. Review Methods Three subpanels with co-chairs comprising experts in the virology, bacteriology, and immunology of otitis media were formed. Each of the panels reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a second draft was created. The entire panel met at the 10th International Symposium on Recent Advances in Otitis Media in June 2011 and discussed the review and refined the content further. A final draft was created, circulated, and approved by the panel. Conclusion Excellent progress has been made in the past 4 years in advancing an understanding of the microbiology and immunology of otitis media. Advances include laboratory-based basic studies, cell-based assays, work in animal models, and clinical studies. Implications for Practice The advances of the past 4 years formed the basis of a series of short-term and long-term research goals in an effort to guide the field. Accomplishing these goals will provide opportunities for the development of novel interventions, including new ways to better treat and prevent otitis media. PMID:23536533

  10. Aerospace Safety Advisory Panel

    NASA Astrophysics Data System (ADS)

    1993-03-01

    The Aerospace Safety Advisory Panel (ASAP) provided oversight on the safety aspects of many NASA programs. In addition, ASAP undertook three special studies. At the request of the Administrator, the panel assessed the requirements for an assured crew return vehicle (ACRV) for the space station and reviewed the organization of the safety and mission quality function within NASA. At the behest of Congress, the panel formed an independent, ad hoc working group to examine the safety and reliability of the space shuttle main engine. Section 2 presents findings and recommendations. Section 3 consists of information in support of these findings and recommendations. Appendices A, B, C, and D, respectively, cover the panel membership, the NASA response to the findings and recommendations in the March 1992 report, a chronology of the panel's activities during the reporting period, and the entire ACRV study report.

  11. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Aerospace Safety Advisory Panel (ASAP) provided oversight on the safety aspects of many NASA programs. In addition, ASAP undertook three special studies. At the request of the Administrator, the panel assessed the requirements for an assured crew return vehicle (ACRV) for the space station and reviewed the organization of the safety and mission quality function within NASA. At the behest of Congress, the panel formed an independent, ad hoc working group to examine the safety and reliability of the space shuttle main engine. Section 2 presents findings and recommendations. Section 3 consists of information in support of these findings and recommendations. Appendices A, B, C, and D, respectively, cover the panel membership, the NASA response to the findings and recommendations in the March 1992 report, a chronology of the panel's activities during the reporting period, and the entire ACRV study report.

  12. ICFA neutrino panel report

    SciTech Connect

    Long, K.

    2015-07-15

    In the summer of 2013 the International Committee on Future Accelerators (ICFA) established a Neutrino Panel with the mandate: <<>>In its first year the Panel organised a series of regional Town Meetings to collect input from the community and to receive reports from the regional planning exercises. The Panel distilled its findings and presented them in a report to ICFA [1]. In this contribution the formation and composition of the Panel are presented together with a summary of the Panel’s findings from the three Regional Town Meetings. The Panel’s initial conclusions are then articulated and the steps that the Panel seeks to take are outlined.

  13. Airborne Sense and Avoid Radar Panel

    DTIC Science & Technology

    2014-10-01

    land and crop surveys, aerial photography , and critical infrastructure protection—their widespread usage within the National Airspace System is...RFIC) developed for the ABSAA panel enable state-of-the- art performance by providing two indepen- dent channels for the amplification, the phase

  14. Make Your Own Solar Panel.

    ERIC Educational Resources Information Center

    Suzuki, David

    1992-01-01

    Presents an activity in which students make a simulated solar panel to learn about the principles behind energy production using solar panels. Provides information about how solar panels function to produce energy. (MCO)

  15. Make Your Own Solar Panel.

    ERIC Educational Resources Information Center

    Suzuki, David

    1992-01-01

    Presents an activity in which students make a simulated solar panel to learn about the principles behind energy production using solar panels. Provides information about how solar panels function to produce energy. (MCO)

  16. Age-dependent decline in motor evoked potential (MEP) amplitude: with a comment on changes in Parkinson's disease.

    PubMed

    Eisen, A; Siejka, S; Schulzer, M; Calne, D

    1991-06-01

    Peak-to-peak measurement of the maximum amplitude motor evoked potential (MAXMEP) elicited by 20 consecutive transcranial magnetic stimuli recorded from the contracting thenar and hypothenar muscles measured 9.8 +/- 2.0 mV and 7.25 +/- 2.9 mV respectively (P less than 0.01). The ratio of MAXMEP/CMAP measured 92.6 +/- 25.8% and 54.8 +/- 12.3% respectively (P less than 0.001). Repeat studies showed good individual reproducibility. Amplitudes declined linearly with age (r = -0.836 for thenar MAXMEP P less than 0.001). It is argued that MAXMEP related to age is more meaningful than the MEP/CMAP wave ratio and is proportional to the number of fast conducting cortical motor neurons excited. In 7/18 patients with Parkinson's disease (PD) MAXMEP was increased; in 2 other patients MAXMEP was decreased for their age.

  17. Flutter Research on Skin Panels

    NASA Technical Reports Server (NTRS)

    Kordes, Eldon E.; Tuovila, Weimer J.; Guy, Lawrence D.

    1960-01-01

    Representative experimental results are presented to show the current status of the panel flutter problem. Results are presented for unstiffened rectangular panels and for rectangular panels stiffened by corrugated backing. Flutter boundaries are established for all types of panels when considered on the basis of equivalent isotropic plates. The effects of Mach number, differential pressure, and aerodynamic heating on panel flutter are discussed. A flutter analysis of orthotropic panels is presented in the appendix.

  18. Periplasmic vestibule plays an important role for solute recruitment, selectivity, and gating in the Rh/Amt/MEP superfamily.

    PubMed

    Akgun, Ugur; Khademi, Shahram

    2011-03-08

    AmtB, a member of the Rh/Amt/MEP superfamily, is responsible for ammonia transport in Escherichia coli. The ammonia pathway in AmtB consists of a narrow hydrophobic lumen in between hydrophilic periplasmic and cytoplasmic vestibules. A series of molecular dynamics simulations (greater than 0.4 μs in total) were performed to determine the mechanism of solute recruitments and selectivity by the periplasmic vestibule. The results show that the periplasmic vestibule plays a crucial role in solute selectivity, and its solute preferences follow the order of NH4(+) > NH3 > CO2. Based on our results, NH4(+) recruitment is initiated by its interaction with either E70 or E225, highly conserved residues located at the entrance of the vestibule. Subsequently, the backbone carbonyl groups at the periplasmic vestibule direct NH4(+) to the conserved aromatic cage at the bottom of the vestibule (known as the Am1 site). The umbrella sampling simulations suggest that the conserved residue D160 is not directly involved in the ammonia conduction; rather its main function is to keep the structure of periplasmic vestibule intact. The MD simulations also revealed that two partially stacked phenyl rings of F107 and F215, separating the periplasmic vestibule from the hydrophobic lumen, flip open and closed simultaneously with a frequency of approximately 10(8) flipping events per second. These results show how the periplasmic vestibule selectively recruits NH4(+) to the Am1 site, and also that the synchronized flipping of two phenyl rings potentially facilitates the solute transition from the periplasmic vestibule to the hydrophobic lumen in the Rh/Amt/MEP superfamily.

  19. Periplasmic vestibule plays an important role for solute recruitment, selectivity, and gating in the Rh/Amt/MEP superfamily

    PubMed Central

    Akgun, Ugur; Khademi, Shahram

    2011-01-01

    AmtB, a member of the Rh/Amt/MEP superfamily, is responsible for ammonia transport in Escherichia coli. The ammonia pathway in AmtB consists of a narrow hydrophobic lumen in between hydrophilic periplasmic and cytoplasmic vestibules. A series of molecular dynamics simulations (greater than 0.4 μs in total) were performed to determine the mechanism of solute recruitments and selectivity by the periplasmic vestibule. The results show that the periplasmic vestibule plays a crucial role in solute selectivity, and its solute preferences follow the order of . Based on our results, recruitment is initiated by its interaction with either E70 or E225, highly conserved residues located at the entrance of the vestibule. Subsequently, the backbone carbonyl groups at the periplasmic vestibule direct to the conserved aromatic cage at the bottom of the vestibule (known as the Am1 site). The umbrella sampling simulations suggest that the conserved residue D160 is not directly involved in the ammonia conduction; rather its main function is to keep the structure of periplasmic vestibule intact. The MD simulations also revealed that two partially stacked phenyl rings of F107 and F215, separating the periplasmic vestibule from the hydrophobic lumen, flip open and closed simultaneously with a frequency of approximately 108 flipping events per second. These results show how the periplasmic vestibule selectively recruits to the Am1 site, and also that the synchronized flipping of two phenyl rings potentially facilitates the solute transition from the periplasmic vestibule to the hydrophobic lumen in the Rh/Amt/MEP superfamily. PMID:21368153

  20. Ionospheric Storm Reconstructions with a Multimodel Ensemble Prdiction System (MEPS) of Data Assimilation Models: Mid and Low Latitude Dynamics

    NASA Astrophysics Data System (ADS)

    Schunk, R. W.; Scherliess, L.; Eccles, V.; Gardner, L. C.; Sojka, J. J.; Zhu, L.; Pi, X.; Mannucci, A. J.; Komjathy, A.; Wang, C.; Rosen, G.

    2016-12-01

    As part of the NASA-NSF Space Weather Modeling Collaboration, we created a Multimodel Ensemble Prediction System (MEPS) for the Ionosphere-Thermosphere-Electrodynamics system that is based on Data Assimilation (DA) models. MEPS is composed of seven physics-based data assimilation models that cover the globe. Ensemble modeling can be conducted for the mid-low latitude ionosphere using the four GAIM data assimilation models, including the Gauss Markov (GM), Full Physics (FP), Band Limited (BL) and 4DVAR DA models. These models can assimilate Total Electron Content (TEC) from a constellation of satellites, bottom-side electron density profiles from digisondes, in situ plasma densities, occultation data and ultraviolet emissions. The four GAIM models were run for the March 16-17, 2013, geomagnetic storm period with the same data, but we also systematically added new data types and re-ran the GAIM models to see how the different data types affected the GAIM results, with the emphasis on elucidating differences in the underlying ionospheric dynamics and thermospheric coupling. Also, for each scenario the outputs from the four GAIM models were used to produce an ensemble mean for TEC, NmF2, and hmF2. A simple average of the models was used in the ensemble averaging to see if there was an improvement of the ensemble average over the individual models. For the scenarios considered, the ensemble average yielded better specifications than the individual GAIM models. The model differences and averages, and the consequent differences in ionosphere-thermosphere coupling and dynamics will be discussed.

  1. Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation

    PubMed Central

    Hartmann, Michael; Gas-Pascual, Elisabet; Hemmerlin, Andrea; Rohmer, Michel; Bach, Thomas J.

    2015-01-01

    In a preceding study we have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable, carboxy-terminal basic domain of the rice calmodulin CaM61, which naturally bears a CaaL geranylgeranylation motif (GFP-BD-CVIL). By using pathway-specific inhibitors it was there demonstrated that inhibition of the methylerythritol phosphate (MEP) pathway with oxoclomazone and fosmidomycin, as well as inhibition of protein geranylgeranyl transferase type 1 (PGGT-1), shifted the localization of the GFP-BD-CVIL protein from the membrane to the nucleus. In contrast, the inhibition of the mevalonate (MVA) pathway with mevinolin did not affect this localization. Furthermore, in this initial study complementation assays with pathway-specific intermediates confirmed that the precursors for the cytosolic isoprenylation of this fusion protein are predominantly provided by the MEP pathway. In order to optimize this visualization system from a more qualitative assay to a statistically trustable medium or a high-throughput screening system, we established now new conditions that permit culture and analysis in 96-well microtiter plates, followed by fluorescence microscopy. For further refinement, the existing GFP-BD-CVIL cell line was transformed with an estradiol-inducible vector driving the expression of a RFP protein, C-terminally fused to a nuclear localization signal (NLS-RFP). We are thus able to quantify the total number of viable cells versus the number of inhibited cells after various treatments. This approach also includes a semi-automatic counting system, based on the freely available image processing software. As a result, the time of image analysis as well as the risk of user-generated bias is reduced to a minimum. Moreover, there is no cross-induction of gene expression by dexamethasone and estradiol, which is an

  2. Panel 4: Report of the Microbiology Panel

    PubMed Central

    Barenkamp, Stephen J.; Chonmaitree, Tasnee; Hakansson, Anders P.; Heikkinen, Terho; King, Samantha; Nokso-Koivisto, Johanna; Novotny, Laura A.; Patel, Janak A.; Pettigrew, Melinda; Swords, W. Edward

    2017-01-01

    Objective To perform a comprehensive review of the literature from July 2011 until June 2015 on the virology and bacteriology of otitis media in children. Data Sources PubMed database of the National Library of Medicine. Review Methods Two subpanels comprising experts in the virology and bacteriology of otitis media were created. Each panel reviewed the relevant literature in the fields of virology and bacteriology and generated draft reviews. These initial reviews were distributed to all panel members prior to meeting together at the Post-symposium Research Conference of the 18th International Symposium on Recent Advances in Otitis Media, National Harbor, Maryland, in June 2015. A final draft was created, circulated, and approved by all panel members. Conclusions Excellent progress has been made in the past 4 years in advancing our understanding of the microbiology of otitis media. Numerous advances were made in basic laboratory studies, in animal models of otitis media, in better understanding the epidemiology of disease, and in clinical practice. Implications for Practice (1) Many viruses cause acute otitis media without bacterial coinfection, and such cases do not require antibiotic treatment. (2) When respiratory syncytial virus, metapneumovirus, and influenza virus peak in the community, practitioners can expect to see an increase in clinical otitis media cases. (3) Biomarkers that predict which children with upper respiratory tract infections will develop otitis media may be available in the future. (4) Compounds that target newly identified bacterial virulence determinants may be available as future treatment options for children with otitis media. PMID:28372529

  3. Autoimmune liver disease panel

    MedlinePlus

    Liver disease test panel - autoimmune ... Autoimmune disorders are a possible cause of liver disease. The most common of these diseases are autoimmune hepatitis and primary biliary cirrhosis. This group of tests helps your health care provider ...

  4. Blue Ribbon Panel Report

    Cancer.gov

    An NCI Cancer Currents blog by the NCI acting director thanking the cancer community for contributing to the Cancer Moonshot Blue Ribbon Panel report, which was presented to the National Cancer Advisory Board on September 7.

  5. Blood Test: Lipid Panel

    MedlinePlus

    ... HDL) and bad (LDL) cholesterol, as well as triglycerides (a certain type of fat). A lipid panel ... results for your good and bad cholesterol and triglycerides.Good (HDL) cholesterol: Your body needs good cholesterol ...

  6. FIFRA Scientific Advisory Panel

    EPA Pesticide Factsheets

    Experts on the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel provide independent scientific advice to the EPA on a wide range of health and safety issues related to pesticides.

  7. Hepatic (Liver) Function Panel

    MedlinePlus

    ... related side effects. The hepatic function panel evaluates: Alanine aminotransferase (ALT). This enzyme, found in the liver, ... MORE ON THIS TOPIC Mononucleosis Hepatitis Blood Test: Alanine Aminotransferase (ALT, or SGPT) Blood Test: Aspartate Aminotransferase ( ...

  8. CF Mutation Panel

    MedlinePlus

    ... AACC products and services. Advertising & Sponsorship: Policy | Opportunities CF Gene Mutations Testing Share this page: Was this page helpful? Also known as: Cystic Fibrosis Genotyping; CF DNA Analysis; CF Gene Mutation Panel; ...

  9. Comprehensive Metabolic Panel

    MedlinePlus

    ... page helpful? Also known as: CMP; Chem 12; Chemistry Panel; Chemistry Screen; SMA 12; SMA 20; SMAC (somewhat outdated ... Health Professionals ©2001 - by American Association for Clinical Chemistry • Contact Us | Terms of Use | Privacy We comply ...

  10. BMP (Basic Metabolic Panel)

    MedlinePlus

    ... Was this page helpful? Also known as: BMP; Chemistry Panel; Chemistry Screen; Chem 7; SMA 7; SMAC7 (somewhat outdated ... Health Professionals ©2001 - by American Association for Clinical Chemistry • Contact Us | Terms of Use | Privacy We comply ...

  11. The effect of cost-sharing in private health insurance on the utilization of health care services between private insurance purchasers and non-purchasers: a study of the Korean health panel survey (2008-2012).

    PubMed

    Choi, Young; Kim, Jae-Hyun; Yoo, Ki-Bong; Cho, Kyoung Hee; Choi, Jae-Woo; Lee, Tae Hoon; Kim, Woorim; Park, Eun-Cheol

    2015-10-28

    Private health insurance in South Korea mainly functions as supplementary and complementary health insurance that compensates for insufficient coverage by National Health Insurance. However, full private coverage of public sector cost-sharing led to the problem of encouraging moral hazard-induced utilization, resulting in a policy change that occurred in October 2009. At that time, the Korean government introduced a minimum cost-sharing policy for indemnity health insurance. The purpose of this study was to analyze the effect of cost-sharing in private health insurance on health care utilization. We analyzed data collected from the Korean Health Panel Survey from October 2008 to December 2011. We restricted the two groups to 803 purchasers with indemnity health insurance and 7023 non-purchasers who did not obtain any private health insurance. A difference-in-difference analysis was used to evaluate the effect of the 2009 policy. After the policy change, the utilization of outpatient visits by purchasers gradually decreased more than non-purchasers (0.015 in 2009 [p = 0.758], -0.117 in 2010 [p < 0.016], and -0.140 in 2011 [p = 0.004]). However, utilization of inpatient services was not statistically significant. Notably, the magnitude of the cost-sharing effect in indemnity health insurance was stronger for those receiving medical aid. Among this group, utilization of outpatient services (after the policy change in 2009) decreased more so than non-purchasers. Patients with three or more chronic diseases have not changed their health care utilization. Our results implied meaningful lessons for decision-makers and future health insurance policies in Korea and other countries in terms of cost-sharing in medical care. When policy makers intend to implement the cost-sharing, a different copayment scheme is needed according to the socioeconomic status or disease severity.

  12. Propulsion Systems Panel deliberations

    NASA Technical Reports Server (NTRS)

    Bianca, Carmelo J.; Miner, Robert; Johnston, Lawrence M.; Bruce, R.; Dennies, Daniel P.; Dickenson, W.; Dreshfield, Robert; Karakulko, Walt; Mcgaw, Mike; Munafo, Paul M.

    1993-01-01

    The Propulsion Systems Panel was established because of the specialized nature of many of the materials and structures technology issues related to propulsion systems. This panel was co-chaired by Carmelo Bianca, MSFC, and Bob Miner, LeRC. Because of the diverse range of missions anticipated for the Space Transportation program, three distinct propulsion system types were identified in the workshop planning process: liquid propulsion systems, solid propulsion systems and nuclear electric/nuclear thermal propulsion systems.

  13. Hexagon solar power panel

    DOEpatents

    Rubin, Irwin

    1978-01-01

    A solar energy panel comprises a support upon which silicon cells are arrayed. The cells are wafer thin and of two geometrical types, both of the same area and electrical rating, namely hexagon cells and hourglass cells. The hourglass cells are composites of half hexagons. A near perfect nesting relationship of the cells achieves a high density packing whereby optimum energy production per panel area is achieved.

  14. Gas filled panel insulation

    DOEpatents

    Griffith, Brent T.; Arasteh, Dariush K.; Selkowitz, Stephen E.

    1993-01-01

    A structural or flexible highly insulative panel which may be translucent, is formed from multi-layer polymeric material in the form of an envelope surrounding a baffle. The baffle is designed so as to minimize heat transfer across the panel, by using material which forms substantially closed spaces to suppress convection of the low conductivity gas fill. At least a portion of the baffle carries a low emissivity surface for suppression of infrared radiation.

  15. Gas filled panel insulation

    DOEpatents

    Griffith, B.T.; Arasteh, D.K.; Selkowitz, S.E.

    1993-12-14

    A structural or flexible highly insulative panel which may be translucent, is formed from multi-layer polymeric material in the form of an envelope surrounding a baffle. The baffle is designed so as to minimize heat transfer across the panel, by using material which forms substantially closed spaces to suppress convection of the low conductivity gas fill. At least a portion of the baffle carries a low emissivity surface for suppression of infrared radiation. 18 figures.

  16. Pop-Art Panels

    ERIC Educational Resources Information Center

    Alford, Joanna

    2012-01-01

    James Rosenquist's giant Pop-art panels included realistic renderings of well-known contemporary foods and objects, juxtaposed with famous people in the news--largely from the 1960s, '70s and '80s--and really serve as visual time capsules. In this article, eighth-graders focus on the style of James Rosenquist to create their own Pop-art panel that…

  17. Photovoltaic panel support assembly

    SciTech Connect

    Barker, J.M.; Underwood, J.C.; Shingleton, J.

    1993-07-20

    A solar energy electrical power source is described comprising in combination at least two flat photovoltaic panels disposed side-by-side in co-planar relation with one another, a pivot shaft extending transversely across the panels, at least two supports spaced apart lengthwise of the pivot shaft, means for connecting the pivot shaft to the at least two supports, attachment means for connecting the at least two panels to the pivot shaft so that the panels can pivot about the longitudinal axis of the shaft, coupling means mechanically coupling all of the panels together so as to form a unified flat array, and selectively operable drive means for mechanically pivoting the unified flat array about the axis; wherein each of the flat photovoltaic panels comprises at least two modules each comprising a plurality of electrically interconnected photovoltaic cells, the at least two modules being aligned along a line extending at a right angle to the pivot shaft, and the coupling means comprises (a) an elongate member extending parallel to and spaced from the pivot shaft and (b) means for attaching the elongate member to the panels; and further wherein each flat photovoltaic panel comprises a unitary frame consisting of a pair of end frame members extending parallel to the pivot shaft, a pair of side frame members extending between and connected to the end frame members, and a pair of spaced apart cross frame members, with one of the two modules being embraced by and secured to the side frame members and a first one of each of the end and cross frame members, and the other of the two modules being embraced by and secured to the side frame members and the second one of each of the end and cross frame members, whereby the gap created by the spaced apart cross frame members allow air to pass between them in order to reduce the sail effect when the solar array is subjected to buffeting winds.

  18. Hexagon solar power panel

    NASA Technical Reports Server (NTRS)

    Rubin, I. (Inventor)

    1978-01-01

    A solar energy panel support is described upon which silicon cells are arrayed. The cells are wafer thin and of two geometrical types, both of the same area and electrical rating, namely hexagon cells and hourglass cells. The hourglass cells are composites of half hexagons. A near perfect nesting relationship of the cells achieves a high density packing whereby optimum energy production per panel area is achieved.

  19. Pop-Art Panels

    ERIC Educational Resources Information Center

    Alford, Joanna

    2012-01-01

    James Rosenquist's giant Pop-art panels included realistic renderings of well-known contemporary foods and objects, juxtaposed with famous people in the news--largely from the 1960s, '70s and '80s--and really serve as visual time capsules. In this article, eighth-graders focus on the style of James Rosenquist to create their own Pop-art panel that…

  20. Novel bioassay for the discovery of inhibitors of the 2-C-Methyl-D-Erythritol 4-Phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis

    USDA-ARS?s Scientific Manuscript database

    The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl-phosphate (IPP) in plastids. It is a major branch point providing precursors for the synthesis of carotenoids, tocopherols, plastoquinone and the phytyl chain of chlorophylls, as well as the hormones abscisi...

  1. Novel Bioassay for the Discovery of Inhibitors of the 2-C-Methyl-D-erythritol 4-Phosphate (MEP) and Terpenoid Pathways Leading to Carotenoid Biosynthesis

    PubMed Central

    Corniani, Natália; Velini, Edivaldo D.; Silva, Ferdinando M. L.; Nanayakkara, N. P. Dhammika; Witschel, Matthias; Dayan, Franck E.

    2014-01-01

    The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a major branch point providing precursors for the synthesis of carotenoids, tocopherols, plastoquinone and the phytyl chain of chlorophylls, as well as the hormones abscisic acid and gibberellins. Consequently, disruption of this pathway is harmful to plants. We developed an in vivo bioassay that can measure the carbon flow through the carotenoid pathway. Leaf cuttings are incubated in the presence of a phytoene desaturase inhibitor to induce phytoene accumulation. Any compound reducing the level of phytoene accumulation is likely to interfere with either one of the steps in the MEP pathway or the synthesis of geranylgeranyl diphosphate. This concept was tested with known inhibitors of steps of the MEP pathway. The specificity of this in vivo bioassay was also verified by testing representative herbicides known to target processes outside of the MEP and carotenoid pathways. This assay enables the rapid screen of new inhibitors of enzymes preceding the synthesis of phytoene, though there are some limitations related to the non-specific effect of some inhibitors on this assay. PMID:25077957

  2. Novel bioassay for the discovery of inhibitors of the 2-C-methyl-D-erythritol 4-phosphate (MEP) and terpenoid pathways leading to carotenoid biosynthesis.

    PubMed

    Corniani, Natália; Velini, Edivaldo D; Silva, Ferdinando M L; Nanayakkara, N P Dhammika; Witschel, Matthias; Dayan, Franck E

    2014-01-01

    The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a major branch point providing precursors for the synthesis of carotenoids, tocopherols, plastoquinone and the phytyl chain of chlorophylls, as well as the hormones abscisic acid and gibberellins. Consequently, disruption of this pathway is harmful to plants. We developed an in vivo bioassay that can measure the carbon flow through the carotenoid pathway. Leaf cuttings are incubated in the presence of a phytoene desaturase inhibitor to induce phytoene accumulation. Any compound reducing the level of phytoene accumulation is likely to interfere with either one of the steps in the MEP pathway or the synthesis of geranylgeranyl diphosphate. This concept was tested with known inhibitors of steps of the MEP pathway. The specificity of this in vivo bioassay was also verified by testing representative herbicides known to target processes outside of the MEP and carotenoid pathways. This assay enables the rapid screen of new inhibitors of enzymes preceding the synthesis of phytoene, though there are some limitations related to the non-specific effect of some inhibitors on this assay.

  3. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1998-01-01

    During 1997, the Aerospace Safety Advisory Panel (ASAP) continued its safety reviews of NASA's human space flight and aeronautics programs. Efforts were focused on those areas that the Panel believed held the greatest potential to impact safety. Continuing safe Space Shuttle operations and progress in the manufacture and testing of primary components for the International Space Station (ISS) were noteworthy. The Panel has continued to monitor the safety implications of the transition of Space Shuttle operations to the United Space Alliance (USA). One area being watched closely relates to the staffing levels and skill mix in both NASA and USA. Therefore, a section of this report is devoted to personnel and other related issues that are a result of this change in NASA's way of doing business for the Space Shuttle. Attention will continue to be paid to this important topic in subsequent reports. Even though the Panel's activities for 1997 were extensive, fewer specific recommendations were formulated than has been the case in recent years. This is indicative of the current generally good state of safety of NASA programs. The Panel does, however, have several longer term concerns that have yet to develop to the level of a specific recommendation. These are covered in the introductory material for each topic area in Section 11. In another departure from past submissions, this report does not contain individual findings and recommendations for the aeronautics programs. While the Panel devoted its usual efforts to examining NASA's aeronautic centers and programs, no specific recommendations were identified for inclusion in this report. In lieu of recommendations, a summary of the Panel's observations of NASA's safety efforts in aeronautics and future Panel areas of emphasis is provided. With profound sadness the Panel notes the passing of our Chairman, Paul M. Johnstone, on December 17, 1997, and our Staff Assistant, Ms. Patricia M. Harman, on October 5, 1997. Other

  4. 76 FR 20711 - Hearings of the Review Panel on Prison Rape

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Office of Justice Programs Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs... Review Panel on Prison Rape (Panel) will hold hearings in Washington, DC on April 26-27, 2011. The... rape, respectively, based on an anonymous survey by the BJS of inmates in a representative sample of U...

  5. 75 FR 27000 - Hearings of the Review Panel on Prison Rape

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... of Justice Programs Hearings of the Review Panel on Prison Rape AGENCY: Office of Justice Programs... Review Panel on Prison Rape (Panel) will hold hearings in Washington, DC on June 3-4, 2010. The hearing... incidence of rape, respectively, based on an anonymous survey by the BJS of youth in a representative sample...

  6. Heat Pipe Thermal Conditioning Panel

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.

    1973-01-01

    The development, fabrication, and evaluation of heat pipe thermal conditioning panels are discussed. The panels were designed and fabricated to be compatible with several planned NASA space vehicles, in terms of panel size, capacity, temperature gradients, and integration with various heat exchangers and electronic components. It was satisfactorily demonstrated that the heat pipe thermal conditioning panel meets the thermal efficiency and heat transport requirements.

  7. Optimization of aircraft interior panels

    NASA Technical Reports Server (NTRS)

    Kourtides, Demetrius A.; Roper, Willard D.

    1986-01-01

    Eight different graphite composite panels were fabricated using four different resin matrices. The resin matrices included Hercules 71775, a blend of vinylpolystyrpyridine and bismaleimide, H795, a bismaleimide, Cycom 6162, a phenolic, and PSP 6022M, a polystyrylpyridine. Graphite panels were fabricated using fabric or unidirectional tape. This report describes the processes for preparing these panels and some of their mechanical, thermal and flammability properties. Panel properties are compared with state-of-the-art epoxy fiberglass composite panels.

  8. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Aerospace Safety Advisory Panel (ASAP) monitored NASA's activities and provided feedback to the NASA Administrator, other NASA officials and Congress throughout the year. Particular attention was paid to the Space Shuttle, its launch processing and planned and potential safety improvements. The Panel monitored Space Shuttle processing at the Kennedy Space Center (KSC) and will continue to follow it as personnel reductions are implemented. There is particular concern that upgrades in hardware, software, and operations with the potential for significant risk reduction not be overlooked due to the extraordinary budget pressures facing the agency. The authorization of all of the Space Shuttle Main Engine (SSME) Block II components portends future Space Shuttle operations at lower risk levels and with greater margins for handling unplanned ascent events. Throughout the year, the Panel attempted to monitor the safety activities related to the Russian involvement in both space and aeronautics programs. This proved difficult as the working relationships between NASA and the Russians were still being defined as the year unfolded. NASA's concern for the unique safety problems inherent in a multi-national endeavor appears appropriate. Actions are underway or contemplated which should be capable of identifying and rectifying problem areas. The balance of this report presents 'Findings and Recommendations' (Section 2), 'Information in Support of Findings and Recommendations' (Section 3) and Appendices describing Panel membership, the NASA response to the March 1994 ASAP report, and a chronology of the panel's activities during the reporting period (Section 4).

  9. Panel methods: An introduction

    NASA Technical Reports Server (NTRS)

    Erickson, Larry L.

    1990-01-01

    Panel methods are numerical schemes for solving (the Prandtl-Glauert equation) for linear, inviscid, irrotational flow about aircraft flying at subsonic or supersonic speeds. The tools at the panel-method user's disposal are (1) surface panels of source-doublet-vorticity distributions that can represent nearly arbitrary geometry, and (2) extremely versatile boundary condition capabilities that can frequently be used for creative modeling. Panel-method capabilities and limitations, basic concepts common to all panel-method codes, different choices that were made in the implementation of these concepts into working computer programs, and various modeling techniques involving boundary conditions, jump properties, and trailing wakes are discussed. An approach for extending the method to nonlinear transonic flow is also presented. Three appendices supplement the main test. In appendix 1, additional detail is provided on how the basic concepts are implemented into a specific computer program (PANAIR). In appendix 2, it is shown how to evaluate analytically the fundamental surface integral that arises in the expressions for influence-coefficients, and evaluate its jump property. In appendix 3, a simple example is used to illustrate the so-called finite part of the improper integrals.

  10. Laboratory testing for von Willebrand's disease: an assessment of current diagnostic practice and efficacy by means of a multi-laboratory survey. RCPA Quality Assurance Program (QAP) in Haematology Haemostasis Scientific Advisory Panel.

    PubMed

    Favaloro, E J; Smith, J; Petinos, P; Hertzberg, M; Koutts, J

    1999-10-01

    We report an evaluation of current laboratory practice for the diagnosis of von Willebrand's disease (VWD) by means of a multilaboratory survey. This assessment was undertaken with the RCPA Quality Assurance Program (QAP) in Haematology, which covers a wide geographic area encompassing Australia, New Zealand and Asia. A total of 25 laboratories actively involved in testing for VWD were selected to participate in a sample testing assessment exercise. Samples comprised 10 plasmas: (i) a normal plasma pool (in duplicate), (ii) this pool diluted to 50% (in duplicate), (iii) a normal individual (X1), (iv) severe Type 1 VWD (X1), (v) Type 2B VWD (x2 unrelated donors), (vi) Type 3 VWD (x1), (vii) Type 2A VWD (x1). Laboratories were asked to perform all tests available to them in order to establish a laboratory diagnosis of VWD, and then to comment on the possibility or otherwise of VWD. Overall findings indicated a wide variation in test practice, in the effectiveness of various test procedures in detecting VWD, and in the ability of various composite test panels to identify type 2 VWD subtypes. Firstly, while all laboratories (n = 25) performed tests for FVIII:C activity, von Willebrand factor 'antigen' (VWF:Ag) and a functional VWF assay [using the ristocetin cofactor assay (VWF:RCo; n = 23) and/or the collagen binding assay (VWF:CBA; n = 12)], only three laboratories carried out VWF:Multimer analysis. Secondly, for the three quantitative VWF assays, 10/25 (40%) laboratories performed all three, whereas 15/25 (60%) performed only two [VWF:Ag and VWF:RCo (n = 13); VWF:Ag and VWF:CBA (n = 2)]. Thirdly, a variety of assay methodologies were evident for VWF:Ag [ELISA, electro-immuno diffusion (EID), latex immuno-assay (LIA), and VIDAS assay] and VWF:RCo (platelet agglutination/'aggregometry' and a 'functional VWF:RCo-alternative' ELISA assay). Between method analysis for the quantitative VWF assays showed that the VWF:RCo yielded the greatest degree of inter

  11. Toward a theory for millennial-scale climate variability through application of MEP in a simple dynamical model

    NASA Astrophysics Data System (ADS)

    Rial, J.; Noone, D.; Nordstrom, K.; Chase, T.; Gupta, V.

    2005-12-01

    Paleoclimate records contain a wealth of information about the character of climate variability and change. However, interpretation of these records is confounded by the lack of both a sufficient theory of climate system behavior and knowledge of those parameters that govern the character of the behavior. While one might argue that these concerns can be largely overcome by employing complex models of the climate system, interpretation of such models requires first a context for understanding simulation results. Further, it is yet to be demonstrated that indeed complex climate models can capture the internal and forced variability seen in proxy records. Specifically, it is not known if the ability to capture this variability has inadvertently been removed from the models range of possible behaviors due to the desire to tune parameterizations to closely reproduce contemporary climate. In view of these concerns, we use a simple model of the climate system that is sustained away from thermodynamic equilibrium by an energy flow. This model predicts the global mean temperature of the ocean from energy balance. Prediction of sea ice extent provides a nonlinear feedback the ocean temperature, thereby introducing into the model non-trivial internal oscillatory behavior. Such a simple model necessarily has a small number of tunable parameters. With selection of reasonable values for these parameters it has been shown to satisfactorily produce variability reminiscent of the Dansgaard-Oeschger variability observed in Northern Hemisphere proxy records. We take the view that the system should organize itself such that it will attain a regime that maximizes the production of entropy (MEP). By defining a thermodynamic entropy and maximizing it with respect to our free parameters, we determine an optimal parameter set. Here we examine how this selection differs from those estimated from physical arguments. In so doing, we show how the estimation of parameters can be used to argue

  12. Panel management, team culture, and worklife experience.

    PubMed

    Willard-Grace, Rachel; Dubé, Kate; Hessler, Danielle; O'Brien, Bridget; Earnest, Gillian; Gupta, Reena; Shunk, Rebecca; Grumbach, Kevin

    2015-09-01

    Burnout and professional dissatisfaction are threats to the primary care workforce. We investigated the relationship between panel management capability, team culture, cynicism, and perceived "do-ability" of primary care among primary care providers (PCPs) and staff in primary care practices. We surveyed 326 PCPs and 142 staff members in 10 county-administered, 6 university-run, and 3 Veterans Affairs primary care clinics in a large urban area in 2013. Predictor variables included capability for performing panel management and perception of team culture. Outcome variables included 2 work experience measures--the Maslach Burnout Inventory cynicism scale and a 1-item measure of the "do-ability" of primary care this year compared with last year. Generalized Estimation Equation (GEE) models were used to account for clustering at the clinic level. Greater panel management capability and higher team culture were associated with lower cynicism among PCPs and staff and higher reported "do-ability" of primary care among PCPs. Panel management capability and team culture interacted to predict the 2 work experience outcomes. Among PCPs and staff reporting high team culture, there was little association between panel management capability and the outcomes, which were uniformly positive. However, there was a strong relationship between greater panel management capability and improved work experience outcomes for PCPs and staff reporting low team culture. Team-based processes of care such as panel management may be an important strategy to protect against cynicism and dissatisfaction in primary care, particularly in settings that are still working to improve their team culture. (c) 2015 APA, all rights reserved).

  13. Origami of thick panels

    NASA Astrophysics Data System (ADS)

    Chen, Yan; Peng, Rui; You, Zhong

    2015-07-01

    Origami patterns, including the rigid origami patterns in which flat inflexible sheets are joined by creases, are primarily created for zero-thickness sheets. In order to apply them to fold structures such as roofs, solar panels, and space mirrors, for which thickness cannot be disregarded, various methods have been suggested. However, they generally involve adding materials to or offsetting panels away from the idealized sheet without altering the kinematic model used to simulate folding. We develop a comprehensive kinematic synthesis for rigid origami of thick panels that differs from the existing kinematic model but is capable of reproducing motions identical to that of zero-thickness origami. The approach, proven to be effective for typical origami, can be readily applied to fold real engineering structures.

  14. Vehicle Systems Panel deliberations

    NASA Technical Reports Server (NTRS)

    Bales, Tom; Modlin, Tom; Suddreth, Jack; Wheeler, Tom; Tenney, Darrel R.; Bayless, Ernest O.; Lisagor, W. Barry; Bolstad, Donald A.; Croop, Harold; Dyer, J.

    1993-01-01

    The Vehicle Systems Panel addressed materials and structures technology issues related to launch and space vehicle systems not directly associated with the propulsion or entry systems. The Vehicle Systems Panel was comprised of two subpanels - Expendable Launch Vehicles & Cryotanks (ELVC) and Reusable Vehicles (RV). Tom Bales, LaRC, and Tom Modlin, JSC, chaired the expendable and reusable vehicles subpanels, respectively, and co-chaired the Vehicle Systems Panel. The following four papers are discussed in this section: (1) Net Section components for Weldalite Cryogenic Tanks, by Don Bolstad; (2) Build-up Structures for Cryogenic Tanks and Dry Bay Structural Applications, by Barry Lisagor; (3) Composite Materials Program, by Robert Van Siclen; (4) Shuttle Technology (and M&S Lessons Learned), by Stan Greenberg.

  15. Oven wall panel construction

    DOEpatents

    Ellison, Kenneth; Whike, Alan S.

    1980-04-22

    An oven roof or wall is formed from modular panels, each of which comprises an inner fabric and an outer fabric. Each such fabric is formed with an angle iron framework and somewhat resilient tie-bars or welded at their ends to flanges of the angle irons to maintain the inner and outer frameworks in spaced disposition while minimizing heat transfer by conduction and permitting some degree of relative movement on expansion and contraction of the module components. Suitable thermal insulation is provided within the module. Panels or skins are secured to the fabric frameworks and each such skin is secured to a framework and projects laterally so as slidingly to overlie the adjacent frame member of an adjacent panel in turn to permit relative movement during expansion and contraction.

  16. Advanced solar panel designs

    NASA Technical Reports Server (NTRS)

    Ralph, E. L.; Linder, E.

    1995-01-01

    This paper describes solar cell panel designs that utilize new hgih efficiency solar cells along with lightweight rigid panel technology. The resulting designs push the W/kg and W/sq m parameters to new high levels. These new designs are well suited to meet the demand for higher performance small satellites. This paper reports on progress made on two SBIR Phase 1 contracts. One panel design involved the use of large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells of 19% efficiency combined with a lightweight rigid graphite fiber epoxy isogrid substrate configuration. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power level of 60 W/kg with a potential of reaching 80 W/kg. The second panel design involved the use of newly developed high efficiency (22%) dual junction GaInP2/GaAs/Ge solar cells combined with an advanced lightweight rigid substrate using aluminum honeycomb core with high strength graphite fiber mesh facesheets. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power of 105 W/kg and 230 W/sq m. This paper will address the construction details of the panels and an a analysis of the component weights. A strawman array design suitable for a typical small-sat mission is described for each of the two panel design technologies being studied. Benefits in respect to weight reduction, area reduction, and system cost reduction are analyzed and compared to conventional arrays.

  17. Advanced solar panel designs

    NASA Astrophysics Data System (ADS)

    Ralph, E. L.; Linder, E.

    1995-10-01

    This paper describes solar cell panel designs that utilize new hgih efficiency solar cells along with lightweight rigid panel technology. The resulting designs push the W/kg and W/sq m parameters to new high levels. These new designs are well suited to meet the demand for higher performance small satellites. This paper reports on progress made on two SBIR Phase 1 contracts. One panel design involved the use of large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells of 19% efficiency combined with a lightweight rigid graphite fiber epoxy isogrid substrate configuration. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power level of 60 W/kg with a potential of reaching 80 W/kg. The second panel design involved the use of newly developed high efficiency (22%) dual junction GaInP2/GaAs/Ge solar cells combined with an advanced lightweight rigid substrate using aluminum honeycomb core with high strength graphite fiber mesh facesheets. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power of 105 W/kg and 230 W/sq m. This paper will address the construction details of the panels and an a analysis of the component weights. A strawman array design suitable for a typical small-sat mission is described for each of the two panel design technologies being studied. Benefits in respect to weight reduction, area reduction, and system cost reduction are analyzed and compared to conventional arrays.

  18. Advanced solar panel designs

    NASA Technical Reports Server (NTRS)

    Ralph, E. L.; Linder, E.

    1995-01-01

    This paper describes solar cell panel designs that utilize new hgih efficiency solar cells along with lightweight rigid panel technology. The resulting designs push the W/kg and W/sq m parameters to new high levels. These new designs are well suited to meet the demand for higher performance small satellites. This paper reports on progress made on two SBIR Phase 1 contracts. One panel design involved the use of large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells of 19% efficiency combined with a lightweight rigid graphite fiber epoxy isogrid substrate configuration. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power level of 60 W/kg with a potential of reaching 80 W/kg. The second panel design involved the use of newly developed high efficiency (22%) dual junction GaInP2/GaAs/Ge solar cells combined with an advanced lightweight rigid substrate using aluminum honeycomb core with high strength graphite fiber mesh facesheets. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power of 105 W/kg and 230 W/sq m. This paper will address the construction details of the panels and an a analysis of the component weights. A strawman array design suitable for a typical small-sat mission is described for each of the two panel design technologies being studied. Benefits in respect to weight reduction, area reduction, and system cost reduction are analyzed and compared to conventional arrays.

  19. Panel 3 - characterization

    SciTech Connect

    Erck, R.A.; Erdemir, A.; Janghsing Hsieh; Lee, R.H.; Xian Zheng Pan; Deming Shu; Feldman, A.; Glass, J.T.; Kleimer, R.; Lawton, E.A.

    1993-01-01

    The task of this panel was to identify and prioritize needs in the area of characterization of diamond and diamond-like-carbon (DLC) films for use in the transportation industry. Until recent advances in production of inexpensive films of diamonds and DLC, it was not feasible that these materials could be mass produced. The Characterization Panel is restricting itself to identifying needs in areas that would be most useful to manufacturers and users in producing and utilizing diamond and DLC coatings in industry. These characterization needs include in-situ monitoring during growth, relation of structure to performance, and standards and definitions.

  20. PRSEUS Acoustic Panel Fabrication

    NASA Technical Reports Server (NTRS)

    Nicolette, Velicki; Yovanof, Nicolette P.; Baraja, Jaime; Mathur, Gopal; Thrash, Patrick; Pickell, Robert

    2011-01-01

    This report describes the development of a novel structural concept, Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS), that addresses the demanding fuselage loading requirements for the Hybrid Wing or Blended Wing Body (BWB) airplane configuration with regards to acoustic response. A PRSEUS panel was designed and fabricated and provided to NASA-LaRC for acoustic response testing in the Structural Acoustics Loads and Transmission (SALT) facility). Preliminary assessments of the sound transmission characteristics of a PRSEUS panel subjected to a representative Hybrid Wing Body (HWB) operating environment were completed for the NASA Environmentally Responsible Aviation (ERA) Program.

  1. Analysis of Panel Data

    NASA Astrophysics Data System (ADS)

    Hsiao, Cheng

    2003-02-01

    Panel data models have become increasingly popular among applied researchers due to their heightened capacity for capturing the complexity of human behavior, as compared to cross-sectional or time series data models. This second edition represents a substantial revision of the highly successful first edition (1986). Recent advances in panel data research are presented in an accessible manner and are carefully integrated with the older material. The thorough discussion of theory and the judicious use of empirical examples make this book useful to graduate students and advanced researchers in economics, business, sociology and political science.

  2. Spectroscopic investigation, vibrational assignments, HOMO-LUMO, NBO, MEP analysis and molecular docking studies of oxoaporphine alkaloid liriodenine

    NASA Astrophysics Data System (ADS)

    Costa, Renyer A.; Pitt, Priscilla Olliveira; Pinheiro, Maria Lucia B.; Oliveira, Kelson M. T.; Salomé, Kahlil Schwanka; Barison, Andersson; Costa, Emmanoel Vilaça

    2017-03-01

    A combined experimental and theoretical DFT study of the structural, vibrational and electronic properties of liriodenine is presented using B3LYP function with 6-311G (2d, p) basis set. The theoretical geometry optimization data were compared with the X-ray data for a similar structure in the associated literature, showing similar values. In addition, natural bond orbitals (NBOs), HOMO-LUMO energy gap, mapped molecular Electrostatic Potential (MEP) surface calculation, first and second order hyperpolarizabilities were also performed with the same calculation level. Theoretical UV spectrum agreed well with the measured experimental data, with transitions assigned. The molecular electrostatic potential map shows opposite potentials regions that forms hydrogen bonds that stabilize the dimeric form, which were confirmed by the close values related to the C dbnd O bond stretching between the dimeric form and the experimental IR spectra (1654 cm- 1 for the experimental, 1700 cm- 1 for the dimer form). Calculated HOMO/LUMO gaps shows the excitation energy for Liriodenine, justifying its stability and kinetics reaction. Molecular docking studies with Candida albicans dihydrofolate reductase (DHFR) and Candida albicans secreted aspartic protease (SAP) showed binding free energies values of - 8.5 and - 8.3 kcal/mol, suggesting good affinity between the liriodenine and the target macromolecules.

  3. Comprehensive metabolic panel

    MedlinePlus

    ... Chem-20; SMA20; Sequential multi-channel analysis with computer-20; SMAC20; Metabolic panel 20 References McPherson RA, ... urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows ...

  4. Advanced Solar Panel Designs

    NASA Technical Reports Server (NTRS)

    Ralph, E. L.; Linder, E. B.

    1995-01-01

    Solar panel designs that utilize new high-efficiency solar cells and lightweight rigid panel technologies are described. The resulting designs increase the specific power (W/kg) achievable in the near-term and are well suited to meet the demands of higher performance small satellites (smallsats). Advanced solar panel designs have been developed and demonstrated on two NASA SBIR contracts at Applied Solar. The first used 19% efficient, large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells with a lightweight rigid graphite epoxy isogrid substrate configuration. A 1,445 sq cm coupon was fabricated and tested to demonstrate 60 W/kg with a high potential of achieving 80 W/kg. The second panel design used new 22% efficiency, dual-junction GaInP2/GaAs/Ge solar cells combined with a lightweight aluminum core/graphite fiber mesh facesheet substrate. A 1,445 sq cm coupon was fabricated and tested to demonstrate 105 W/kg with the potential of achieving 115 W/kg.

  5. Photovoltaic-Panel Laminator

    NASA Technical Reports Server (NTRS)

    Keenan, R.

    1985-01-01

    Two-piece unit heats and presses protective layers to form laminate. Rubber diaphragm between upper and lower vacuum chambers alternates between neutral position and one that presses against solar-cell array, supplying distributed force necessary to press layers of laminate together. Encapsulation helps to protect cells from environment and to ensure long panel life while allowing efficient generation of electricity from Sunlight.

  6. Stepped inlet optical panel

    DOEpatents

    Veligdan, James T.

    2001-01-01

    An optical panel includes stacked optical waveguides having stepped inlet facets collectively defining an inlet face for receiving image light, and having beveled outlet faces collectively defining a display screen for displaying the image light channeled through the waveguides by internal reflection.

  7. Photovoltaic-Panel Laminator

    NASA Technical Reports Server (NTRS)

    Keenan, R.

    1985-01-01

    Two-piece unit heats and presses protective layers to form laminate. Rubber diaphragm between upper and lower vacuum chambers alternates between neutral position and one that presses against solar-cell array, supplying distributed force necessary to press layers of laminate together. Encapsulation helps to protect cells from environment and to ensure long panel life while allowing efficient generation of electricity from Sunlight.

  8. The Panel Discussion.

    ERIC Educational Resources Information Center

    Journal of Chemical Education, 1980

    1980-01-01

    Summarizes the views of panel members at a symposium on the place of inorganic chemistry in the undergraduate curriculum. Suggests one semester of intermediate inorganic chemistry, followed by a year of physical chemistry and a semester of advanced inorganic chemistry as a reasonable prescription for the modern undergraduate curriculum. (Author/JN)

  9. Panels: Papers and Summaries.

    ERIC Educational Resources Information Center

    Besser, Howard; And Others

    1994-01-01

    Contains student papers and abstracts of panel discussions on the following topics: (1) social impact of networked communications; (2) text authenticity issues; (3) geographic information systems; (4) the dilemma of open networks versus information accuracy and personal rights; and (5) empowering medical applications via the network. (KRN)

  10. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This report covers the activities of the Aerospace Safety Advisory Panel (ASAP) for calendar year 1998-a year of sharp contrasts and significant successes at NASA. The year opened with the announcement of large workforce cutbacks. The slip in the schedule for launching the International Space Station (ISS) created a five-month hiatus in Space Shuttle launches. This slack period ended with the successful and highly publicized launch of the STS-95 mission. As the year closed, ISS assembly began with the successful orbiting and joining of the Functional Cargo Block (FGB), Zarya, from Russia and the Unity Node from the United States. Throughout the year, the Panel maintained its scrutiny of NASA's safety processes. Of particular interest were the potential effects on safety of workforce reductions and the continued transition of functions to the Space Flight Operations Contractor. Attention was also given to the risk management plans of the Aero-Space Technology programs, including the X-33, X-34, and X-38. Overall, the Panel concluded that safety is well served for the present. The picture is not as clear for the future. Cutbacks have limited the depth of talent available. In many cases, technical specialties are 'one deep.' The extended hiring freeze has resulted in an older workforce that will inevitably suffer significant departures from retirements in the near future. The resulting 'brain drain' could represent a future safety risk unless appropriate succession planning is started expeditiously. This and other topics are covered in the section addressing workforce. The major NASA programs are also limited in their ability to plan property for the future. This is of particular concern for the Space Shuttle and ISS because these programs are scheduled to operate well into the next century. In the case of the Space Shuttle, beneficial and mandatory safety and operational upgrades are being delayed because of a lack of sufficient present funding. Likewise, the ISS has

  11. Histone H2A and H4 N-terminal tails are positioned by the MEP50 WD repeat protein for efficient methylation by the PRMT5 arginine methyltransferase.

    PubMed

    Burgos, Emmanuel S; Wilczek, Carola; Onikubo, Takashi; Bonanno, Jeffrey B; Jansong, Janina; Reimer, Ulf; Shechter, David

    2015-04-10

    The protein arginine methyltransferase PRMT5 is complexed with the WD repeat protein MEP50 (also known as Wdr77 or androgen coactivator p44) in vertebrates in a tetramer of heterodimers. MEP50 is hypothesized to be required for protein substrate recruitment to the catalytic domain of PRMT5. Here we demonstrate that the cross-dimer MEP50 is paired with its cognate PRMT5 molecule to promote histone methylation. We employed qualitative methylation assays and a novel ultrasensitive continuous assay to measure enzyme kinetics. We demonstrate that neither full-length human PRMT5 nor the Xenopus laevis PRMT5 catalytic domain has appreciable protein methyltransferase activity. We show that histones H4 and H3 bind PRMT5-MEP50 more efficiently compared with histone H2A(1-20) and H4(1-20) peptides. Histone binding is mediated through histone fold interactions as determined by competition experiments and by high density histone peptide array interaction studies. Nucleosomes are not a substrate for PRMT5-MEP50, consistent with the primary mode of interaction via the histone fold of H3-H4, obscured by DNA in the nucleosome. Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5. We show that PRMT5-MEP50 prefers unmethylated substrates, consistent with a distributive model for dimethylation and suggesting discrete biological roles for mono- and dimethylarginine-modified proteins. We propose a model in which MEP50 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  12. Histone H2A and H4 N-terminal Tails Are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase*

    PubMed Central

    Burgos, Emmanuel S.; Wilczek, Carola; Onikubo, Takashi; Bonanno, Jeffrey B.; Jansong, Janina; Reimer, Ulf; Shechter, David

    2015-01-01

    The protein arginine methyltransferase PRMT5 is complexed with the WD repeat protein MEP50 (also known as Wdr77 or androgen coactivator p44) in vertebrates in a tetramer of heterodimers. MEP50 is hypothesized to be required for protein substrate recruitment to the catalytic domain of PRMT5. Here we demonstrate that the cross-dimer MEP50 is paired with its cognate PRMT5 molecule to promote histone methylation. We employed qualitative methylation assays and a novel ultrasensitive continuous assay to measure enzyme kinetics. We demonstrate that neither full-length human PRMT5 nor the Xenopus laevis PRMT5 catalytic domain has appreciable protein methyltransferase activity. We show that histones H4 and H3 bind PRMT5-MEP50 more efficiently compared with histone H2A(1–20) and H4(1–20) peptides. Histone binding is mediated through histone fold interactions as determined by competition experiments and by high density histone peptide array interaction studies. Nucleosomes are not a substrate for PRMT5-MEP50, consistent with the primary mode of interaction via the histone fold of H3-H4, obscured by DNA in the nucleosome. Mutation of a conserved arginine (Arg-42) on the MEP50 insertion loop impaired the PRMT5-MEP50 enzymatic efficiency by increasing its histone substrate Km, comparable with that of Caenorhabditis elegans PRMT5. We show that PRMT5-MEP50 prefers unmethylated substrates, consistent with a distributive model for dimethylation and suggesting discrete biological roles for mono- and dimethylarginine-modified proteins. We propose a model in which MEP50 and PRMT5 simultaneously engage the protein substrate, orienting its targeted arginine to the catalytic site. PMID:25713080

  13. Advanced solar panel designs

    NASA Technical Reports Server (NTRS)

    Ralph, E. L.; Linder, E. B.

    1996-01-01

    Solar panel designs that utilize new high-efficiency solar cells and lightweight rigid panel technologies are described. The resulting designs increase the specific power (W/kg) achievable in the near-term and are well suited to meet the demands of higher performance small satellites (smallsats). Advanced solar panel designs have been developed and demonstrated on two NASA SBIR contracts at Applied Solar. The first used 19% efficient, large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells with a lightweight rigid graphite epoxy isogrid substrate configuration. A 1,445 cm(exp 2) coupon was fabricated and tested to demonstrate 60 W/kg with a high potential of achieving 80 W/kg. The second panel design used new 22% efficiency, dual junction GaInP2/GaAs/Ge solar cells combined with a lightweight aluminum core/graphite fiber mesh facesheet substrate. A 1,445 cm(exp 2) coupon was fabricated and tested to demonstrate 105 W/kg with the potential of achieving 115 W/kg. This paper will address the construction details for the GaAs/isogrid and dual-junction GaAs/carbon mesh panel configurations. These are ultimately sized to provide 75 Watts and 119 Watts respectively for smallsats or may be used as modular building blocks for larger systems. GaAs/isogrid and dual-junction GaAs/carbon mesh coupons have been fabricated and tested to successfully demonstrate critical performance parameters and results are also provided here.

  14. Nontenure-Track Science Personnel: Opportunities for Independent Research. Higher Education Panel Reports, No. 39.

    ERIC Educational Resources Information Center

    Gomberg, Irene L.; Atelsek, Frank J.

    The Higher Education Panel of the American Council on Education conducted a survey to determine the size and characteristics of nontenure-track personnel at doctoral-level institutions and the extent to which these personnel are principal investigators in research projects. The survey involved 247 selected Panel institutions that award the Ph.D.…

  15. Diffusion tensor tractography of pyramidal tracts in patients with brainstem and intramedullary spinal cord tumors: Relationship with motor deficits and intraoperative MEP changes.

    PubMed

    Czernicki, Tomasz; Maj, Edyta; Podgórska, Anna; Kunert, Przemysław; Prokopienko, Marek; Nowak, Arkadiusz; Cieszanowski, Andrzej; Marchel, Andrzej

    2017-09-01

    To evaluate whether pyramidal tracts course alterations observed in diffusion tensor tractography (DTT) in cases of brainstem and intramedullary spinal cord tumors reflect patient clinical status and prognosis. For this purpose, we assessed in 17 patients relationships between pyramidal tracts course alterations observed in DTT (classified into four categories: unaffected; displaced or interspaced; partially disintegrated and completely disintegrated) performed on a 1.5 Tesla scanner and the presence of preoperative motor deficits, changes observed in motor evoked potentials (MEPs) records at the beginning of the operation, deterioration of the MEPs records during the operation, and perioperative deterioration of muscle strength. We found that, if the picture of pyramidal tracts in DTT was worse, motor deficit was more common (P = 0.062). This observation was even more evident (P = 0.027), when cases with at least partially destroyed pyramidal tracts were compared with cases with normal or at most displaced or interspaced by tumor but still preserved pyramidal tracts. Significant relationships were also found between changes in DTT and abnormal MEP records at the beginning of the operation (P = 0.032) and perioperative deterioration of muscle strength (P = 0.0058). A close relationship was found between pyramidal tracts course alterations in DTT imaging and preoperative motor status and especially with changes in the MEP records at the beginning of the operation. DTT may be a method that allows the better planning of brainstem and intramedullary spinal cord tumors operations and may help in the risk assessment of postoperative motor deficits. 3 Technical Efficacy: Stage 4 J. MAGN. RESON. IMAGING 2017;46:715-723. © 2017 International Society for Magnetic Resonance in Medicine.

  16. Draft Genome Sequence of Highly Virulent Race 4/Biovar 3 of Ralstonia solanacearum CaRs_Mep Causing Bacterial Wilt in Zingiberaceae Plants in India.

    PubMed

    Kumar, Aundy; Munjal, Vibhuti; Sheoran, Neelam; Prameela, Thekkan Puthiyaveedu; Suseelabhai, Rajamma; Aggarwal, Rashmi; Jain, Rakesh Kumar; Eapen, Santhosh J

    2017-01-05

    The genome of Ralstonia solanacearum CaRs_Mep, a race 4/biovar 3/phylotype I bacterium causing wilt in small cardamom and other Zingiberaceae plants, was sequenced. Analysis of the 5.7-Mb genome sequence will aid in better understanding of the genetic determinants of host range, host jump, survival, pathogenicity, and virulence of race 4 of R. solanacearum. Copyright © 2017 Kumar et al.

  17. Spared Primary Motor Cortex and The Presence of MEP in Cerebral Palsy Dictate the Responsiveness to tDCS during Gait Training

    PubMed Central

    Grecco, Luanda A. Collange; Oliveira, Claudia Santos; Galli, Manuela; Cosmo, Camila; Duarte, Natália de Almeida Carvalho; Zanon, Nelci; Edwards, Dylan J.; Fregni, Felipe

    2016-01-01

    The current priority of investigations involving transcranial direct current stimulation (tDCS) and neurorehabilitation is to identify biomarkers associated with the positive results of the interventions such that respondent and non-respondent patients can be identified in the early phases of treatment. The aims were to determine whether: (1) present motor evoked potential (MEP); and (2) injuries involving the primary motor cortex, are associated with tDCS-enhancement in functional outcome following gait training in children with cerebral palsy (CP). We reviewed the data from our parallel, randomized, sham-controlled, double-blind studies. Fifty-six children with spastic CP received gait training (either treadmill training or virtual reality training) and tDCS (active or sham). Univariate and multivariate logistic regression analyses were employed to identify clinical, neurophysiologic and neuroanatomic predictors associated with the responsiveness to treatment with tDCS. MEP presence during the initial evaluation and the subcortical injury were associated with positive effects in the functional results. The logistic regression revealed that present MEP was a significant predictor for the six-minute walk test (6MWT; p = 0.003) and gait speed (p = 0.028), whereas the subcortical injury was a significant predictor of gait kinematics (p = 0.013) and gross motor function (p = 0.021). In this preliminary study involving children with CP, two important prediction factors of good responses to anodal tDCS combined with gait training were identified. Apparently, MEP (integrity of the corticospinal tract) and subcortical location of the brain injury exerted different influences on aspects related to gait, such as velocity and kinematics. PMID:27486393

  18. Theoretical studies of the mechanism of the action of the neurohypophyseal hormones. I. Molecular electrostatic potential (MEP) and molecular electrostatic field (MEF) maps of some vasopressin analogues

    NASA Astrophysics Data System (ADS)

    Liwo, Adam; Tempczyk, Anna; Grzonka, Zbigniew

    1989-09-01

    Continuing our theoretical studies of the oxytocin and vasopressin analogues, we have analysed the molecular electrostatic potential (MEP) and the norm of the molecular electrostatic field (MEF) of [1- β-mercaptopropionic acid]-arginine-vasopressin ([Mpa1]-AVP), [1-( β-mercapto- β,β-cyclopentamethylene)propionic acid]-arginine-vasopressin ([Cpp']-AVP), and [1-thiosalicylic acid]-arginine-vasopressin ([Ths']-AVP) whose low-energy conformations were calculated in our previous work. These compounds are known from experiment to exhibit different biological activity. The scalar fields mentioned determine the energy of interaction with either charged (MEP) or polar (MEF) species, the energy being in the second case either optimal or Boltzmann-averaged over all the possible orientations of the dipole moment versus the electrostatic field. The electrostatic interactions slowly vanish with distance and can therefore be considered to be the factor determining the molecular shape at greater distances, which can help in both predicting the interactions with the receptor at the stage of remote recognition and in finding the preferred directions of solvation by a polar solvent. In the analysis of the fields three techniques have been used: (i) the construction of maps in certain planes; (ii) the construction of maps on spheres centered in the charge center of the molecule under study and of poles chosen according to the main axes of the quadrupole moment; and (iii) the construction of surfaces corresponding to a given value of potential. The results obtained show that the shapes of both MEP and MEF are similar in the case of [Mpa1]-AVP and [Cpp1-AVP (biologically active), while some differences emerge when comparing these compounds with [Ths1]-AVP (inactive). It has also been found that both MEP and MEF depend even more strongly on conformation.

  19. Draft Genome Sequence of Highly Virulent Race 4/Biovar 3 of Ralstonia solanacearum CaRs_Mep Causing Bacterial Wilt in Zingiberaceae Plants in India

    PubMed Central

    Munjal, Vibhuti; Sheoran, Neelam; Prameela, Thekkan Puthiyaveedu; Suseelabhai, Rajamma; Aggarwal, Rashmi; Jain, Rakesh Kumar; Eapen, Santhosh J.

    2017-01-01

    ABSTRACT The genome of Ralstonia solanacearum CaRs_Mep, a race 4/biovar 3/phylotype I bacterium causing wilt in small cardamom and other Zingiberaceae plants, was sequenced. Analysis of the 5.7-Mb genome sequence will aid in better understanding of the genetic determinants of host range, host jump, survival, pathogenicity, and virulence of race 4 of R. solanacearum. PMID:28057749

  20. LCD Panels: The Electronic Wonder.

    ERIC Educational Resources Information Center

    Anderson, Glenn

    1994-01-01

    Describes Liquid Crystal Display (LCD) panels and their use in the classroom. Topics discussed include active versus passive matrix panels; the number of pixels; projectors, including transmissive or reflective overhead projectors; costs; and vendors that supply LCDs. (LRW)

  1. Report of Industry Panel Group

    NASA Technical Reports Server (NTRS)

    Gallimore, Simon; Gier, Jochen; Heitland, Greg; Povinelli, Louis; Sharma, Om; VandeWall, Allen

    2006-01-01

    A final report is presented from the industry panel group. The contents include: 1) General comments; 2) Positive progress since Minnowbrook IV; 3) Industry panel outcome; 4) Prioritized turbine projects; 5) Prioritized compressor projects; and 6) Miscellaneous.

  2. Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs.

    PubMed

    Wilczek, Carola; Chitta, Raghu; Woo, Eileen; Shabanowitz, Jeffrey; Chait, Brian T; Hunt, Donald F; Shechter, David

    2011-12-09

    Histone proteins carry information contained in post-translational modifications. Eukaryotic cells utilize this histone code to regulate the usage of the underlying DNA. In the maturing oocytes and eggs of the frog Xenopus laevis, histones are synthesized in bulk in preparation for deposition during the rapid early developmental cell cycles. During this key developmental time frame, embryonic pluripotent chromatin is established. In the egg, non-chromatin-bound histones are complexed with storage chaperone proteins, including nucleoplasmin. Here we describe the identification and characterization of a complex of the protein arginine methyltransferase 5 (Prmt5) and the methylosome protein 50 (Mep50) isolated from Xenopus eggs that specifically methylates predeposition histones H2A/H2A.X-F and H4 and the histone chaperone nucleoplasmin on a conserved motif (GRGXK). We demonstrate that nucleoplasmin (Npm), an exceedingly abundant maternally deposited protein, is a potent substrate for Prmt5-Mep50 and is monomethylated and symmetrically dimethylated at Arg-187. Furthermore, Npm modulates Prmt5-Mep50 activity directed toward histones, consistent with a regulatory role for Npm in vivo. We show that H2A and nucleoplasmin methylation appears late in oogenesis and is most abundant in the laid egg. We hypothesize that these very abundant arginine methylations are constrained to pre-mid blastula transition events in the embryo and therefore may be involved in the global transcriptional repression found in this developmental time frame.

  3. Mounting clips for panel installation

    DOEpatents

    Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph

    2017-07-11

    A photovoltaic panel mounting clip comprising a base, central indexing tabs, flanges, lateral indexing tabs, and vertical indexing tabs. The mounting clip removably attaches one or more panels to a beam or the like structure, both mechanically and electrically. It provides secure locking of the panels in all directions, while providing guidance in all directions for accurate installation of the panels to the beam or the like structure.

  4. Merging Q-theory and MEP theory to explain some geographical variations seen in Russian soil C inventory data

    NASA Astrophysics Data System (ADS)

    Yurova, Alla

    2016-04-01

    Soils are as critical for understanding the ecosystem carbon cycle as plants are and here I critically evaluate some of the commonly used assumptions embedded into the soil organic matter dynamics process-based models. According to the biochemical concept (e.g. Mindermann, 1968) plant residues can be divided into liable and more recalcitrant fractions, each decomposing with a specific rate (increasing with temperature) and it is remains of recalcitrant compounds that accumulate to form soil organic matter. The application of this theory in regional to global biogeochemical models leads to conclusion that the high latitude soils stores the highest amount of carbon per square meter due to high percentage of recalcitrant compounds and low temperature. This contradicts with the Russian soil inventory data, demonstrating that within the large span of biomes present in Russia that is steepe that has the highest soil C storage. Here I take an alternative, most theoretical, viewpoint, called Q-theory (from q-quality) (Ågren and Bosatta, 1996) considering the changes in the continuous variable-the quality of the organic matter in the soil as a starting point. I then derive the novel equation for the entropy production of humification process and demonstrate how MEP theory works to explain geographical differences in soil C accumulation seen in Russian soil inventory data. Conceptually close to the work presented is a general theory of humification (Orlov, 1995) based on thermodynamic view on decomposition postulating that independently on acting factors and the soil type it is only the most thermodynamically stable components, such as humic substances, that will be produced and stored in the process of organic matter transformation This work was supported by RFBR grants 15-05-01368 A

  5. Spectroscopic (infrared, Raman, UV and NMR) analysis, Gaussian hybrid computational investigation (MEP maps/HOMO and LUMO) on cyclohexanone oxime

    NASA Astrophysics Data System (ADS)

    Ramalingam, S.; Karabacak, M.; Periandy, S.; Puviarasan, N.; Tanuja, D.

    2012-10-01

    In the present analysis, FT-IR/FT-Raman spectra of the cyclohexanone oxime (CHO, C6H11NO) are recorded. The observed vibrational frequencies are assigned and the computational calculations are carried out by HF and DFT (B3LYP and B3PW91) methods with 6-311++G(d,p) basis set and the corresponding results are tabulated. In order to yield good coherence with observed values, the calculated frequencies are scaled by appropriate scale factors. The complete assignments are performed on the basis of the total energy distribution (TED) of the vibrational modes, calculated with scaled quantum mechanics (SQM) method. The alternation of structure of cyclohexanone due to the substitution of NOH is investigated. The vibrational sequence pattern of the molecule related to the substitutions is analyzed. Comparison of the observed fundamental vibrational frequencies of CHO and calculated results by density functional (B3LYP and B3PW91) and HF methods indicates that B3LYP is superior to the scaled HF and B3PW91 approach for molecular vibrational problems. Moreover, 13C NMR and 1H NMR chemical shifts are calculated by using the gauge independent atomic orbital (GIAO) method with HF/B3LYP/B3PW91 methods and the same basis set. A study on the electronic properties; absorption wavelengths, excitation energy, dipole moment and frontier molecular orbital energies, are performed by HF and DFT methods. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. Besides frontier molecular orbitals (FMO), molecular electrostatic potential (MEP) was performed. NLO properties and Mulliken charges of the CHO was also calculated and interpreted. The thermodynamic properties (heat capacity, entropy, and enthalpy) of the title compound at different temperatures are calculated in gas phase.

  6. Spectroscopic (infrared, Raman, UV and NMR) analysis, Gaussian hybrid computational investigation (MEP maps/HOMO and LUMO) on cyclohexanone oxime.

    PubMed

    Ramalingam, S; Karabacak, M; Periandy, S; Puviarasan, N; Tanuja, D

    2012-10-01

    In the present analysis, FT-IR/FT-Raman spectra of the cyclohexanone oxime (CHO, C(6)H(11)NO) are recorded. The observed vibrational frequencies are assigned and the computational calculations are carried out by HF and DFT (B3LYP and B3PW91) methods with 6-311++G(d,p) basis set and the corresponding results are tabulated. In order to yield good coherence with observed values, the calculated frequencies are scaled by appropriate scale factors. The complete assignments are performed on the basis of the total energy distribution (TED) of the vibrational modes, calculated with scaled quantum mechanics (SQM) method. The alternation of structure of cyclohexanone due to the substitution of NOH is investigated. The vibrational sequence pattern of the molecule related to the substitutions is analyzed. Comparison of the observed fundamental vibrational frequencies of CHO and calculated results by density functional (B3LYP and B3PW91) and HF methods indicates that B3LYP is superior to the scaled HF and B3PW91 approach for molecular vibrational problems. Moreover, (13)C NMR and (1)H NMR chemical shifts are calculated by using the gauge independent atomic orbital (GIAO) method with HF/B3LYP/B3PW91 methods and the same basis set. A study on the electronic properties; absorption wavelengths, excitation energy, dipole moment and frontier molecular orbital energies, are performed by HF and DFT methods. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. Besides frontier molecular orbitals (FMO), molecular electrostatic potential (MEP) was performed. NLO properties and Mulliken charges of the CHO was also calculated and interpreted. The thermodynamic properties (heat capacity, entropy, and enthalpy) of the title compound at different temperatures are calculated in gas phase.

  7. Ionospheric Storm Reconstruction with a Multimodel Ensemble Prediction System (MEPS) of Data Assimilation Models: High Latitude Dynamics

    NASA Astrophysics Data System (ADS)

    Eccles, J. V.; Schunk, R. W.; Scherliess, L.; Gardner, L. C.; Sojka, J. J.; Zhu, L.; Pi, X.; Mannucci, A. J.; Komjathy, A.; Wang, C.; Rosen, G.

    2016-12-01

    As part of the NASA-NSF Space Weather Modeling Collaboration, we created a Multimodel Ensemble Prediction System (MEPS) for the Ionosphere-Thermosphere-Electrodynamics system that is based on Data Assimilation (DA) models. One component is the Ionosphere Dynamics and ElectroDynamics model with Data Assimilation (IDED-DA). The IDED is an ensemble model data-assimilation package that combines 4 physics-based models to incorporate physics-based modeling into the data assimilation technique for high latitudes. The models include the Ionosphere Forecast Model (IFM) for plasma dynamics, Joule heating, and conductivities, an Alfven wave magnetosphere-ionosphere coupling model for consistent physics-based conductivities, potential, and currents, and a magnetic field inversion model to calculate the magnetic deflections produced by the ionosphere currents, including induced ground currents. The IDED-DA model can assimilate magnetic deflections from ground-based magnetometers, line-of-sight plasma velocities from SuperDARN radars, cross-track ion drifts from DMSP satellites, and magnetic deflections from the constellation of AMPERE satellites. We added a fifth data set of GPS TEC to the assimilation as a possible refinement for the convection potential, which can generate high-latitude ionospheric structures. The IDED-DA model was run for the March 15-17, 2013 period with one quiet day (15th) and a geomagnetic storm period (16-17). We ran two simulations using (1) all data types and (2) all data types except TEC. The comparison of these results will quantify the value of high-latitude TEC data for specifying plasma structures and quantify resulting changes of the determined electrodynamics from the assimilated TEC data.

  8. Medical Physics Panel Discussion

    NASA Astrophysics Data System (ADS)

    Guèye, Paul; Avery, Steven; Baird, Richard; Soares, Christopher; Amols, Howard; Tripuraneni, Prabhakar; Majewski, Stan; Weisenberger, Drew

    2006-03-01

    The panel discussion will explore opportunities and vistas in medical physics research and practice, medical imaging, teaching medical physics to undergraduates, and medical physics curricula as a recruiting tool for physics departments. Panel members consist of representatives from NSBP (Paul Guèye and Steven Avery), NIH/NIBIB (Richard Baird), NIST (Christopher Soares), AAPM (Howard Amols), ASTRO (Prabhakar Tripuraneni), and Jefferson Lab (Stan Majewski and Drew Weisenberger). Medical Physicists are part of Departments of Radiation Oncology at hospitals and medical centers. The field of medical physics includes radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. It also ranges from basic researcher (at college institutions, industries, and laboratories) to applications in clinical environments.

  9. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    Phil McAlister, Director of Commercial Spaceflight Development at NASA, delivers remarks panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  10. Interactive Panel Discussion

    NASA Astrophysics Data System (ADS)

    Bernius, Mark

    2014-03-01

    Quo Vadis? Here is the opportunity to ask panel members your questions: seek a forecast of current trends, where are we going as a collection of physicists in a wide variety of employment settings? What is the likelihood of remaining cohesive as those schooled in the fundamentals of physics? How might we better foster collaboration, with the disparate agendas of academia, government and commerce? Come with your questions, and share in this unique opportunity to quiz the experts.

  11. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    Gwynne Shotwell, President of SpaceX, delivers remarks panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  12. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    NASA Administrator Charles Bolden delivers remarks before a panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  13. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    Frank Slazer, Vice President of Space Systems, Aerospace Industries Association, delivers remarks panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  14. Clinical Space Medicine Panel

    NASA Technical Reports Server (NTRS)

    Baisden, Denise L.; Billica, Roger (Technical Monitor)

    2000-01-01

    The practice of space medicine is diverse. It includes routine preventive medical care of astronauts and pilots, the development of inflight medical capability and training of flight crews as well as the preflight, inflight, and postflight medical assessment and monitoring. The Johnson Space Center Medical Operations Branch is a leader in the practice of space medicine. The papers presented in this panel will demonstrate some of the unique aspects of space medicine.

  15. Clinical Space Medicine Panel

    NASA Technical Reports Server (NTRS)

    Baisden, Denise L.; Billica, Roger (Technical Monitor)

    2000-01-01

    The practice of space medicine is diverse. It includes routine preventive medical care of astronauts and pilots, the development of inflight medical capability and training of flight crews as well as the preflight, inflight, and postflight medical assessment and monitoring. The Johnson Space Center Medical Operations Branch is a leader in the practice of space medicine. The papers presented in this panel will demonstrate some of the unique aspects of space medicine.

  16. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    Alan Lindenmoyer, Manager of Commercial Crew and Cargo Program at NASA, delivers remarks panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  17. Conducting online expert panels: a feasibility and experimental replicability study.

    PubMed

    Khodyakov, Dmitry; Hempel, Susanne; Rubenstein, Lisa; Shekelle, Paul; Foy, Robbie; Salem-Schatz, Susanne; O'Neill, Sean; Danz, Margie; Dalal, Siddhartha

    2011-12-23

    This paper has two goals. First, we explore the feasibility of conducting online expert panels to facilitate consensus finding among a large number of geographically distributed stakeholders. Second, we test the replicability of panel findings across four panels of different size. We engaged 119 panelists in an iterative process to identify definitional features of Continuous Quality Improvement (CQI). We conducted four parallel online panels of different size through three one-week phases by using the RAND's ExpertLens process. In Phase I, participants rated potentially definitional CQI features. In Phase II, they discussed rating results online, using asynchronous, anonymous discussion boards. In Phase III, panelists re-rated Phase I features and reported on their experiences as participants. 66% of invited experts participated in all three phases. 62% of Phase I participants contributed to Phase II discussions and 87% of them completed Phase III. Panel disagreement, measured by the mean absolute deviation from the median (MAD-M), decreased after group feedback and discussion in 36 out of 43 judgments about CQI features. Agreement between the four panels after Phase III was fair (four-way kappa=0.36); they agreed on the status of five out of eleven CQI features. Results of the post-completion survey suggest that participants were generally satisfied with the online process. Compared to participants in smaller panels, those in larger panels were more likely to agree that they had debated each others' view points. It is feasible to conduct online expert panels intended to facilitate consensus finding among geographically distributed participants. The online approach may be practical for engaging large and diverse groups of stakeholders around a range of health services research topics and can help conduct multiple parallel panels to test for the reproducibility of panel conclusions.

  18. New respirator fit test panels representing the current Chinese civilian workers.

    PubMed

    Chen, Weihong; Zhuang, Ziqing; Benson, Stacey; Du, Lili; Yu, Dan; Landsittel, Douglas; Wang, Limin; Viscusi, Dennis; Shaffer, Ronald E

    2009-04-01

    Respirator fit test panels provide an objective tool for selecting representative human test subjects based upon their facial characteristics for use in research, product development, testing and certification. Fit test panels were typically based upon anthropometric data such as the 1967-1968 survey of American military personnel. In this study, the objectives were to: (i) evaluate the applicability of the recently developed National Institute for Occupational Safety and Health (NIOSH) respirator fit test panels for Chinese workers and (ii) develop new respirator fit test panels using the Chinese survey data. Overall, 95% of the workers in the Chinese survey fall within the NIOSH bivariate and principal component analysis (PCA) panels, suggesting that these panels would also be appropriate for the Chinese population. However, distribution of the subject across the panels was not uniform; only 6.3% of survey participants fell into five cells of the bivariate panel and only 7.2% were found within three cells of the PCA panel. Therefore, new respirator fit test panels with subject dimensions and distributions specific to Chinese workers may be beneficial for certain applications. Two new respirator fit test panels were developed with the same techniques used to create the NIOSH panels. All measurements were weighted to match age and gender distributions of the Chinese population from the 2005 census. The bivariate approach used face length and face width measurements, and the PCA panel was developed using the first two principal components obtained from a set of 10 facial dimensions. Respirators designed to fit these Chinese worker-specific panels are also likely to accommodate >95% of Chinese workers.

  19. Clinicians' panel management self-efficacy to support their patients' smoking cessation and hypertension control needs.

    PubMed

    Strauss, Shiela M; Jensen, Ashley E; Bennett, Katelyn; Skursky, Nicole; Sherman, Scott E; Schwartz, Mark D

    2015-03-01

    Panel management, a set of tools and processes for proactively caring for patient populations, has potential to reduce morbidity and improve outcomes between office visits. We examined primary care staff's self-efficacy in implementing panel management, its correlates, and an intervention's impact on this self-efficacy. Primary care teams at two Veterans Health Administration (VA) hospitals were assigned to control or intervention conditions. Staff were surveyed at baseline and post-intervention, with a random subset interviewed post-intervention. Panel management self-efficacy was higher among staff participating in the panel management intervention. Self-efficacy was significantly correlated with sufficient training, aspects of team member interaction, and frequency of panel management use. Panel management self-efficacy was modest among primary care staff at two VA hospitals. Team level interventions may improve primary care staff's confidence in practicing panel management, with this greater confidence related to greater team involvement with, and use of panel management.

  20. Heat pipe thermal conditioning panel

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.; Loose, J. D.; Mccoy, K. E.

    1974-01-01

    Thermal control of electronic hardware and experiments on future space vehicles is critical to proper functioning and long life. Thermal conditioning panels (cold plates) are a baseline control technique in current conceptual studies. Heat generating components mounted on the panels are typically cooled by fluid flowing through integral channels within the panel. However, replacing the pumped fluid coolant loop within the panel with heat pipes offers attractive advantages in weight, reliability, and installation. This report describes the development and fabrication of two large 0.76 x 0.76 m heat pipe thermal conditioning panels to verify performance and establish the design concept.

  1. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This Annual Report of the Aerospace Safety Advisory Panel (ASAP) presents results of activities during calendar year 2001. The year was marked by significant achievements in the Space Shuttle and International Space Station (ISS) programs and encouraging accomplishments by the Aerospace Technology Enterprise. Unfortunately, there were also disquieting mishaps with the X-43, a LearJet, and a wind tunnel. Each mishap was analyzed in an orderly process to ascertain causes and derive lessons learned. Both these accomplishments and the responses to the mishaps led the Panel to conclude that safety and risk management is currently being well served within NASA. NASA's operations evidence high levels of safety consciousness and sincere efforts to place safety foremost. Nevertheless, the Panel's safety concerns have never been greater. This dichotomy has arisen because the focus of most NASA programs has been directed toward program survival rather than effective life cycle planning. Last year's Annual Report focused on the need for NASA to adopt a realistically long planning horizon for the aging Space Shuttle so that safety would not erode. NASA's response to the report concurred with this finding. Nevertheless, there has been a greater emphasis on current operations to the apparent detriment of long-term planning. Budget cutbacks and shifts in priorities have severely limited the resources available to the Space Shuttle and ISS for application to risk-reduction and life-extension efforts. As a result, funds originally intended for long-term safety-related activities have been used for operations. Thus, while safety continues to be well served at present, the basis for future safety has eroded. Section II of this report develops this theme in more detail and presents several important, overarching findings and recommendations that apply to many if not all of NASA's programs. Section III of the report presents other significant findings, recommendations and supporting

  2. Large thermal protection system panel

    NASA Technical Reports Server (NTRS)

    Myers, Franklin K. (Inventor); Weinberg, David J. (Inventor); Tran, Tu T. (Inventor)

    2003-01-01

    A protective panel for a reusable launch vehicle provides enhanced moisture protection, simplified maintenance, and increased temperature resistance. The protective panel includes an outer ceramic matrix composite (CMC) panel, and an insulative bag assembly coupled to the outer CMC panel for isolating the launch vehicle from elevated temperatures and moisture. A standoff attachment system attaches the outer CMC panel and the bag assembly to the primary structure of the launch vehicle. The insulative bag assembly includes a foil bag having a first opening shrink fitted to the outer CMC panel such that the first opening and the outer CMC panel form a water tight seal at temperatures below a desired temperature threshold. Fibrous insulation is contained within the foil bag for protecting the launch vehicle from elevated temperatures. The insulative bag assembly further includes a back panel coupled to a second opening of the foil bag such that the fibrous insulation is encapsulated by the back panel, the foil bag, and the outer CMC panel. The use of a CMC material for the outer panel in conjunction with the insulative bag assembly eliminates the need for waterproofing processes, and ultimately allows for more efficient reentry profiles.

  3. Development of Quiet Honeycomb Panels

    NASA Technical Reports Server (NTRS)

    Palumbo, Daniel L.; Klos, Jacob

    2009-01-01

    Sandwich honeycomb composite panels are lightweight and strong, and, therefore, provide a reasonable alternative to the aluminum ring framelstringer architecture currently used for most aircraft airframes. The drawback to honeycomb panels is that they radiate noise into the aircraft cabin very efficiently provoking the need for additional sound treatment which adds weight and reduces the material's cost advantage. A series of honeycomb panels were made which incorporated different design strategies aimed at reducing the honeycomb panels' radiation efficiency while at the same time maintaining its strength. The majority of the desi gns were centered around the concept of creatin g areas of reduced stiffness in the panel by adding voids and recesses to the core. The effort culminated with a reinforced./recessed panel which had 6 dB higher transmission loss than the baseline solid core panel while maintaining comparable strength.

  4. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This report covers the activities of the Aerospace Safety Advisory Panel (ASAP) for calendar year 1998-a year of sharp contrasts and significant successes at NASA. The year opened with the announcement of large workforce cutbacks. The slip in the schedule for launching the International Space Station (ISS) created a 5-month hiatus in Space Shuttle launches. This slack period ended with the successful and highly publicized launch of the STS-95 mission. As the year closed, ISS assembly began with the successful orbiting and joining of the Functional Cargo Block (FGB), Zarya, from Russia and the Unity Node from the United States. Throughout the year, the Panel maintained its scrutiny of NASAs safety processes. Of particular interest were the potential effects on safety of workforce reductions and the continued transition of functions to the Space Flight Operations Contractor. Attention was also given to the risk management plans of the Aero-Space Technology programs, including the X-33, X-34, and X-38. Overall, the Panel concluded that safety is well served for the present. The picture is not as clear for the future. Cutbacks have limited the depth of talent available. In many cases, technical specialties are "one deep." The extended hiring freeze has resulted in an older workforce that will inevitably suffer significant departures from retirements in the near future. The resulting "brain drain" could represent a future safety risk unless appropriate succession planning is started expeditiously. This and other topics are covered in the section addressing workforce. In the case of the Space Shuttle, beneficial and mandatory safety and operational upgrades are being delayed because of a lack of sufficient present funding. Likewise, the ISS has little flexibility to begin long lead-time items for upgrades or contingency planning.

  5. Plate-fin panel heat exchanger and panel components thereof

    SciTech Connect

    Heronemus, W.E.

    1985-02-05

    A plate-fin panel for a heat exchanger may be either formed as an aluminum extrusion or fabricated from a corrugated metal sheet sandwiched between two flat metal sheets. The extruded aluminum version may be clad with protective sheet metal jackets made of, or coated with, a corrosion resistant Cu-Ni alloy. Individual panel sections can be joined together by tongue and groove engagement to obtain a total desired panel width if available extrusion press or rolling mill capacity is insufficient. The plate-fin panels are assembled into slotted headering plates, and a layer of synthetic plastics potting compound seals dissimilar metal joints against electrolytic corrosion as well as leakage and provides sufficient adhesive strength to reduce or eliminate the need for welding the panels to the headers. Mechanical brush or hydraulic jet apparatus is capable of continuously or intermittently cleaning slime or encrustations from all panel surfaces exposed to seawater.

  6. Concentrating photovoltaic solar panel

    DOEpatents

    Cashion, Steven A; Bowser, Michael R; Farrelly, Mark B; Hines, Braden E; Holmes, Howard C; Johnson, Jr., Richard L; Russell, Richard J; Turk, Michael F

    2014-04-15

    The present invention relates to photovoltaic power systems, photovoltaic concentrator modules, and related methods. In particular, the present invention features concentrator modules having interior points of attachment for an articulating mechanism and/or an articulating mechanism that has a unique arrangement of chassis members so as to isolate bending, etc. from being transferred among the chassis members. The present invention also features adjustable solar panel mounting features and/or mounting features with two or more degrees of freedom. The present invention also features a mechanical fastener for secondary optics in a concentrator module.

  7. Photovoltaic panel clamp

    SciTech Connect

    Mittan, Margaret Birmingham; Miros, Robert H. J.; Brown, Malcolm P; Stancel, Robert

    2012-06-05

    A photovoltaic panel clamp includes an upper and lower section. The interface between the assembled clamp halves and the module edge is filled by a flexible gasket material, such as EPDM rubber. The gasket preferably has small, finger like protrusions that allow for easy insertion onto the module edge while being reversed makes it more difficult to remove them from the module once installed. The clamp includes mounting posts or an integral axle to engage a bracket. The clamp also may include a locking tongue to secure the clamp to a bracket.

  8. Photovoltaic panel clamp

    SciTech Connect

    Brown, Malcolm P.; Mittan, Margaret Birmingham; Miros, Robert H. J.; Stancel, Robert

    2013-03-19

    A photovoltaic panel clamp includes an upper and lower section. The interface between the assembled clamp halves and the module edge is filled by a flexible gasket material, such as EPDM rubber. The gasket preferably has small, finger like protrusions that allow for easy insertion onto the module edge while being reversed makes it more difficult to remove them from the module once installed. The clamp includes mounting posts or an integral axle to engage a bracket. The clamp also may include a locking tongue to secure the clamp to a bracket.

  9. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The results of the Panel's activities are presented in a set of findings and recommendations. Highlighted here are both improvements in NASA's safety and reliability activities and specific areas where additional gains might be realized. One area of particular concern involves the curtailment or elimination of Space Shuttle safety and reliability enhancements. Several findings and recommendations address this area of concern, reflecting the opinion that safety and reliability enhancements are essential to the continued successful operation of the Space Shuttle. It is recommended that a comprehensive and continuing program of safety and reliability improvements in all areas of Space Shuttle hardware/software be considered an inherent component of ongoing Space Shuttle operations.

  10. Microsphere Insulation Panels

    NASA Technical Reports Server (NTRS)

    Mohling, R.; Allen, M.; Baumgartner, R.

    2006-01-01

    Microsphere insulation panels (MIPs) have been developed as lightweight, longlasting replacements for the foam and vacuum-jacketed systems heretofore used for thermally insulating cryogenic vessels and transfer ducts. The microsphere core material of a typical MIP consists of hollow glass bubbles, which have a combination of advantageous mechanical, chemical, and thermal-insulation properties heretofore available only separately in different materials. In particular, a core filling of glass microspheres has high crush strength and low density, is noncombustible, and performs well in soft vacuum.

  11. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This report presents the results of the Aerospace Safety Advisory Panel (ASAP) activities during 2002. The format of the report has been modified to capture a long-term perspective. Section II is new and highlights the Panel's view of NASA's safety progress during the year. Section III contains the pivotal safety issues facing NASA in the coming year. Section IV includes the program area findings and recommendations. The Panel has been asked by the Administrator to perform several special studies this year, and the resulting white papers appear in Appendix C. The year has been filled with significant achievements for NASA in both successful Space Shuttle operations and International Space Station (ISS) construction. Throughout the year, safety has been first and foremost in spite of many changes throughout the Agency. The relocation of the Orbiter Major Modifications (OMMs) from California to Kennedy Space Center (KSC) appears very successful. The transition of responsibilities for program management of the Space Shuttle and ISS programs from Johnson Space Center (JSC) to NASA Headquarters went smoothly. The decision to extend the life of the Space Shuttle as the primary NASA vehicle for access to space is viewed by the Panel as a prudent one. With the appropriate investments in safety improvements, in maintenance, in preserving appropriate inventories of spare parts, and in infrastructure, the Space Shuttle can provide safe and reliable support for the ISS for the foreseeable future. Indications of an aging Space Shuttle fleet occurred on more than one occasion this year. Several flaws went undetected in the early prelaunch tests and inspections. In all but one case, the problems were found prior to launch. These incidents were all handled properly and with safety as the guiding principle. Indeed, launches were postponed until the problems were fully understood and mitigating action could be taken. These incidents do, however, indicate the need to analyze the

  12. Microgap flat panel display

    DOEpatents

    Wuest, C.R.

    1998-12-08

    A microgap flat panel display is disclosed which includes a thin gas-filled display tube that utilizes switched X-Y ``pixel`` strips to trigger electron avalanches and activate a phosphor at a given location on a display screen. The panel utilizes the principal of electron multiplication in a gas subjected to a high electric field to provide sufficient electron current to activate standard luminescent phosphors located on an anode. The X-Y conductive strips of a few micron widths may for example, be deposited on opposite sides of a thin insulating substrate, or on one side of the adjacent substrates and function as a cathode. The X-Y strips are separated from the anode by a gap filled with a suitable gas. Electrical bias is selectively switched onto X and Y strips to activate a ``pixel`` in the region where these strips overlap. A small amount of a long-lived radioisotope is used to initiate an electron avalanche in the overlap region when bias is applied. The avalanche travels through the gas filled gap and activates a luminescent phosphor of a selected color. The bias is adjusted to give a proportional electron multiplication to control brightness for given pixel. 6 figs.

  13. Microgap flat panel display

    DOEpatents

    Wuest, Craig R.

    1998-01-01

    A microgap flat panel display which includes a thin gas-filled display tube that utilizes switched X-Y "pixel" strips to trigger electron avalanches and activate a phosphor at a given location on a display screen. The panel utilizes the principal of electron multiplication in a gas subjected to a high electric field to provide sufficient electron current to activate standard luminescent phosphors located on an anode. The X-Y conductive strips of a few micron widths may for example, be deposited on opposite sides of a thin insulating substrate, or on one side of the adjacent substrates and function as a cathode. The X-Y strips are separated from the anode by a gap filled with a suitable gas. Electrical bias is selectively switched onto X and Y strips to activate a "pixel" in the region where these strips overlap. A small amount of a long-lived radioisotope is used to initiate an electron avalanche in the overlap region when bias is applied. The avalanche travels through the gas filled gap and activates a luminescent phosphor of a selected color. The bias is adjusted to give a proportional electron multiplication to control brightness for given pixel.

  14. Solar panel mounting assembly

    SciTech Connect

    Eiden, G.E.

    1990-01-02

    This patent describes a mounting assembly for pivotally connecting a solar panel or collector to a base. The mounting assembly comprising: a frame whereupon the solar panel or collector can be mounted; a first plate connected to the frame, the plate having a pivot hole and a plurality of angle displacement holes each being equidistant from the pivot hole; a second plate connected to the base and situated substantially parallel to the first plate. The second plate having a pivot hole and an angle displacement hole being situated substantially the same distance apart from the second plate pivot hole as the distance between the pivot and displacement holes of the first plate; a pivot shaft received through the plate pivot hole and the second plate pivot hole whereby the frame and first plate can pivot with respect to the second plate and the base; an angle displacement shaft selectively received through the second plate angle displacement hole and any one of the first plate angle displacement holes whereby the frame and first plate can be selectively angularly fixed with respect to the second plate and the base; a U-member having two legs, the second plate being connected to the U-member; and, a selectively rotable shaft.

  15. Solar panel parallel mounting configuration

    NASA Technical Reports Server (NTRS)

    Mutschler, Jr., Edward Charles (Inventor)

    1998-01-01

    A spacecraft includes a plurality of solar panels interconnected with a power coupler and an electrically operated device to provide power to the device when the solar cells are insolated. The solar panels are subject to bending distortion when entering or leaving eclipse. Spacecraft attitude disturbances are reduced by mounting each of the solar panels to an elongated boom made from a material with a low coefficient of thermal expansion, so that the bending of one panel is not communicated to the next. The boom may be insulated to reduce its bending during changes in insolation. A particularly advantageous embodiment mounts each panel to the boom with a single mounting, which may be a hinge. The single mounting prevents transfer of bending moments from the panel to the boom.

  16. Heat Pipe Thermal Conditioning Panel

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.

    1973-01-01

    The technology involved in designing and fabricating a heat pipe thermal conditioning panel to satisfy a broad range of thermal control system requirements on NASA spacecraft is discussed. The design specifications were developed for a 30 by 30 inch heat pipe panel. The fundamental constraint was a maximum of 15 gradient from source to sink at 300 watts input and a flux density of 2 watts per square inch. The results of the performance tests conducted on the panel are analyzed.

  17. Overexpression of SrUGT85C2 from Stevia reduced growth and yield of transgenic Arabidopsis by influencing plastidial MEP pathway.

    PubMed

    Guleria, Praveen; Masand, Shikha; Yadav, Sudesh Kumar

    2014-04-15

    The transcript expression of a gene SrUGT85C2 has been documented for direct relation with steviol glycoside content in Stevia plant. Steviol glycoside and gibberellin biosynthetic routes are divergent branches of methyl erythritol-4 phosphate (MEP) pathway. So, SrUGT85C2 might be an influencing gibberellin content. Hence in the present study, transgenic Arabidopsis thaliana overexpressing SrUGT85C2 cDNA from Stevia rebaudiana was developed to check its effect on gibberellin accumulation and related plant growth parameters. The developed transgenics showed a noteworthy decrease of 78-83% in GA3 content. Moreover, the transgenics showed a gibberellin deficient phenotype comprising stunted hypocotyl length, reduced shoot growth and a significant fall in relative water content. Transgenics also showed 17-37 and 64-76% reduction in chlorophyll a and chlorophyll b contents, respectively. Reduction in photosynthetic pigments could be responsible for the noticed significant decrease in plant biomass. Like steviol glycoside and gibberellin biosynthesis, chlorophyll biosynthesis also occurs from the precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) of MEP pathway in the plastids. The observed downregulated expression of genes encoding MEP pathway enzymes geranyl geranyl diphosphate synthase (GGDPS), copalyl diphosphate synthase (CDPS), kaurenoic acid oxidase (KAO), chlorophyll synthetase and chlorophyll a oxygenase in transgenics overexpressing SrUGT85C2 might be responsible for the reduction in gibberellins as well as chlorophyll. This study has documented for the first time the regulatory role of SrUGT85C2 in the biosynthesis of steviol glycoside, gibberellins and chlorophyll. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. 137. POWER PANEL A (208 VOLTS) AND POWER PANEL B ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    137. POWER PANEL A (208 VOLTS) AND POWER PANEL B (480 VOLTS) ON EAST WALL OF TRANSFORMER ROOM (212), LSB (BLDG. 751) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  19. Optics Alignment Panel

    NASA Technical Reports Server (NTRS)

    Schroeder, Daniel J.

    1992-01-01

    The Optics Alignment Panel (OAP) was commissioned by the HST Science Working Group to determine the optimum alignment of the OTA optics. The goal was to find the position of the secondary mirror (SM) for which there is no coma or astigmatism in the camera images due to misaligned optics, either tilt or decenter. The despace position was reviewed of the SM and the optimum focus was sought. The results of these efforts are as follows: (1) the best estimate of the aligned position of the SM in the notation of HDOS is (DZ,DY,TZ,TY) = (+248 microns, +8 microns, +53 arcsec, -79 arcsec), and (2) the best focus, defined to be that despace which maximizes the fractional energy at 486 nm in a 0.1 arcsec radius of a stellar image, is 12.2 mm beyond paraxial focus. The data leading to these conclusions, and the estimated uncertainties in the final results, are presented.

  20. ALDS 1980 panel review

    SciTech Connect

    Hall, D. L.

    1981-11-01

    The overall goal of PNL (Pacific Northwest Laboratory) Applied Mathematical Sciences Research is development of a DOE (Department of Energy) capability for Analysis of Large Data Sets (ALDS) and transfer of this capability to other DOE laboratories and contractors. This capability is needed to satisfy DOE's increasing requirements for handling and analyzing large volumes of diverse energy and environmental data. The integrated statistics and computer science research includes the development of improved methodologies in data definition, data management, data analysis, and visual display. The purpose of this document is three-fold. First, the document is the permanent record of the ALDS 1979 panel review. Second, the document provides the PNL staff with a benchmark of where we were at the end of the second year of ALDS. Third, the document is available to laboratories, universities, and DOE headquarters as detailed description of the ALDS project, as well as an example of the new direction of AMS-funded research.

  1. COTS Initiative Panel Discussion

    NASA Image and Video Library

    2013-11-13

    L-R: Alan Lindenmoyer, Manager of Commercial Crew and Cargo Program, NASA; Gwynne Shotwell, President, SpaceX; Frank Culbertson, Executive Vice President and General Manager, Orbital Sciences Advanced Programs Group; Frank Slazer, Vice President of Space Systems, Aerospace Industries Association and Phil McAlister, Director of Commercial Spaceflight Development at NASA, participate in a panel discussion on the Commercial Orbital Transportation Services (COTS) initiative at NASA Headquarters in Washington on Wednesday, November 13, 2013. Through COTS, NASA's partners Space Exploration Technologies Corp. (SpaceX) and Orbital Sciences Corp., developed new U.S. rockets and spacecraft, launched from U.S. soil, capable of transporting cargo to low-Earth orbit and the International Space Station. Photo Credit: (NASA/Jay Westcott)

  2. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This annual report is based on the activities of the Aerospace Safety Advisory Panel in calendar year 2000. During this year, the construction of the International Space Station (ISS) moved into high gear. The launch of the Russian Service Module was followed by three Space Shuttle construction and logistics flights and the deployment of the Expedition One crew. Continuous habitation of the ISS has begun. To date, both the ISS and Space Shuttle programs have met or exceeded most of their flight objectives. In spite of the intensity of these efforts, it is clear that safety was always placed ahead of cost and schedule. This safety consciousness permitted the Panel to devote more of its efforts to examining the long-term picture. With ISS construction accelerating, demands on the Space Shuttle will increase. While Russian Soyuz and Progress spacecraft will make some flights, the Space Shuttle remains the primary vehicle to sustain the ISS and all other U.S. activities that require humans in space. Development of a next generation, human-rated vehicle has slowed due to a variety of technological problems and the absence of an approach that can accomplish the task significantly better than the Space Shuttle. Moreover, even if a viable design were currently available, the realities of funding and development cycles suggest that it would take many years to bring it to fruition. Thus, it is inescapable that for the foreseeable future the Space Shuttle will be the only human-rated vehicle available to the U.S. space program for support of the ISS and other missions requiring humans. Use of the Space Shuttle will extend well beyond current planning, and is likely to continue for the life of the ISS.

  3. Thermal-Diode Sandwich Panel

    NASA Technical Reports Server (NTRS)

    Basiulis, A.

    1986-01-01

    Thermal diode sandwich panel transfers heat in one direction, but when heat load reversed, switches off and acts as thermal insulator. Proposed to control temperature in spacecraft and in supersonic missiles to protect internal electronics. In combination with conventional heat pipes, used in solar panels and other heat-sensitive systems.

  4. Age-forming aluminum panels

    NASA Technical Reports Server (NTRS)

    Baxter, G. I.

    1976-01-01

    Contoured-stiffened 63 by 337 inch 2124 aluminum alloy panels are machined in-the-flat to make integral, tapered T-capped stringers, parallel with longitudinal centerline. Aging fixture, which includes net contour formers made from lofted contour templates, has eggcrate-like structure for use in forming and checking panels.

  5. Issues related to panel creep

    Treesearch

    Paul C. Van Deusen

    2002-01-01

    The annual inventory system was designed under the assumption that a fixed percentage of plots would be measured annually in each State. The initial plan was to assign plots to panels to provide systematic coverage of a State. One panel would be measured each year to allow for annual updates of each State using simple estimation procedures. The reality is that...

  6. Expression pattern of fifteen genes of non-mevalonate (MEP) and mevalonate (MVA) pathways in different tissues of endangered medicinal herb Picrorhiza kurroa with respect to picrosides content.

    PubMed

    Pandit, Saurabh; Shitiz, Kirti; Sood, Hemant; Naik, Pradeep Kumar; Chauhan, Rajinder Singh

    2013-02-01

    Picrorhiza kurroa, has become an endangered medicinal herb due to excessive utilization, therefore it necessitates the understanding of biology and molecular basis of major chemical constituents i.e. Picroside-I (P-I) and Picroside-II (P-II). Estimation of P-I and P-II in different tissues of P. kurroa showed that shoots contain only P-I whereas P-II is present only in roots. Differential conditions with varying concentrations of P-I (0-27 μg/mg) and P-II (0-4 μg/mg) were selected. Four genes of MEP pathway; DXPS, ISPD, ISPE, MECPS and one gene of MVA pathway PMK showed elevated levels of transcripts in shoots (57-166 folds) and stolons (5-15 folds) with P-I contents 0-27 μg/mg and 2.9-19.7 μg/mg, respectively. Further HDS and DXPR genes of MEP pathway showed higher expression ~9-12 folds in roots having P-II (0-4 μg/mg). The expression of ISPH and ISPE was also high ~5 folds in roots accumulating P-II. GDPS was the only gene with high transcript level in roots (9 folds) and shoots (20 folds). Differential biosynthesis and accumulation of picrosides would assist in regulating quality of plant material for herbal drug formulations.

  7. Re-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trends.

    PubMed

    Pereira, Jorge; Silva, Catarina Luís; Perestrelo, Rosa; Gonçalves, João; Alves, Vera; Câmara, José S

    2014-03-01

    The human population continues to grow exponentially in the fast developing and most populated countries, whereas in Western Europe it is getting older and older each year. This inevitably raises the demand for better and more efficient medical services without increasing the economic burden in the same proportion. To meet these requirements, improvement of medical diagnosis is certainly a key aspect to consider. Therefore, we need powerful analytical methodologies able to go deeper and further in the characterization of human metabolism and identification of disease biomarkers and endogenous molecules in body fluids and tissues. The ultimate goal is to have a reliable and early medical diagnosis, mitigating the disease complications as much as possible. Microextraction techniques (METs) represent a key step in these analytical methodologies by providing samples in the suitable volumes and purification levels necessary for the characterization of the target analytes. In this aspect, solid-phase microextraction (SPME) and, more recently, microextraction by packed sorbent (MEPS), are powerful sample preparation techniques, characterized by their reduced time of analysis, low solvent consumption, and broad application. Moreover, as miniaturized techniques, they can be easily automatized to have a high-throughput performance in the clinical environment. In this review, we explore some of the most interesting MEPS and SPME applications, focusing on recent trends and applications to medical diagnostic, particularly the in vivo and near real time applications.

  8. Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

    PubMed Central

    Price, Kathryn E.; Armstrong, Christopher M.; Imlay, Leah S.; Hodge, Dana M.; Pidathala, C.; Roberts, Natalie J.; Park, Jooyoung; Mikati, Marwa; Sharma, Raman; Lawrenson, Alexandre S.; Tolia, Niraj H.; Berry, Neil G.; O’Neill, Paul M.; John, Audrey R. Odom

    2016-01-01

    The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d]isothiazol-3(2H)-ones as species-selective inhibitors of Plasmodium spp. 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase (IspD), the third catalytic enzyme of the MEP pathway. 2-Phenyl benzo[d]isothiazol-3(2H)-ones display nanomolar inhibitory activity against P. falciparum and P. vivax IspD and prevent the growth of P. falciparum in culture, with EC50 values below 400 nM. In silico modeling, along with enzymatic, genetic and crystallographic studies, have established a mechanism-of-action involving initial non-covalent recognition of inhibitors at the IspD binding site, followed by disulfide bond formation through attack of an active site cysteine residue on the benzo[d]isothiazol-3(2H)-one core. The species-selective inhibitory activity of these small molecules against Plasmodium spp. IspD and cultured parasites suggests they have potential as lead compounds in the pursuit of novel drugs to treat malaria. PMID:27857147

  9. Microextraction by packed sorbent (MEPS)-UHPLC-UV: A simple and efficient method for the determination of five benzodiazepines in an alcoholic beverage.

    PubMed

    Magrini, Laura; Cappiello, Achille; Famiglini, Giorgio; Palma, Pierangela

    2016-06-05

    This article describes a nano-scale method for the determination and quantification of five benzodiazepines (BDZ) in an alcoholic grappa drink (chlordiazepoxide; lorazepam; diazepam; oxazepam; medazepam). BDZ are typically used in drug-facilitated crimes (DFC) for their accessibility and synergistic effects with alcohol. Specimens collected on the crime scene must be rapidly analyzed to prove the crime, though, in most cases, a very small amount is available. Off-line MEPS extraction of diluted grappa samples proved to be an efficient and reliable method for the recovery of the selected compounds. Requiring a very small amount of extraction solvents, MEPS is an environment-friendly technique. LC separation with UV detection was used as the analytical technique because it is simple, robust, relatively economic and easy-to-find in most laboratories. The method was validated in terms of precision, accuracy and recovery. Limits of detection and quantitation were in the range of 0.5-2ng/μL. Linearity (R(2)) spanned from 0.9994 and 1.0000. Intra- and inter-day repeatabilities were lower than 12% at any concentration. Recovery percentages of an equivalent-to-real sample at three different concentrations were between 70.7 and 74.1%. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Mounting clips for panel installation

    DOEpatents

    Cavieres, Andres; Al-Haddad, Tristan; Goodman, Joseph; Valdes, Francisco

    2017-02-14

    An exemplary mounting clip for removably attaching panels to a supporting structure comprises a base, spring locking clips, a lateral flange, a lever flange, and a spring bonding pad. The spring locking clips extend upwardly from the base. The lateral flange extends upwardly from a first side of the base. The lateral flange comprises a slot having an opening configured to receive at least a portion of one of the one or more panels. The lever flange extends outwardly from the lateral flange. The spring bonding flange extends downwardly from the lever flange. At least a portion of the first spring bonding flange comprises a serrated edge for gouging at least a portion of the one or more panels when the one or more panels are attached to the mounting clip to electrically and mechanically couple the one or more panels to the mounting clip.

  11. Comparing Oral Health Care Utilization Estimates in the United States Across Three Nationally Representative Surveys

    PubMed Central

    Macek, Mark D; Manski, Richard J; Vargas, Clemencia M; Moeller, John

    2002-01-01

    Objective To compare estimates of dental visits among adults using three national surveys. Data Sources/Study Design Cross-sectional data from the National Health Interview Survey (NHIS), National Health and Nutrition Examination Survey (NHANES), and National Health Expenditure surveys (NMCES, NMES, MEPS). Study Design This secondary data analysis assessed whether overall estimates and stratum-specific trends are different across surveys. Data Collection Dental visit data are age standardized via the direct method to the 1990 population of the United States. Point estimates, standard errors, and test statistics are generated using SUDAAN. Principal Findings Sociodemographic, stratum-specific trends are generally consistent across surveys; however, overall estimates differ (NHANES III [364-day estimate] versus 1993 NHIS: –17.5 percent difference, Z=7.27, p value < 0.001; NHANES III [365-day estimate] vs. 1993 NHIS: 5.4 percent difference, Z=–2.50, p value=0.006; MEPS vs. 1993 NHIS: –29.8 percent difference, Z=16.71, p value < 0.001). MEPS is the least susceptible to intrusion, telescoping, and social desirability. Conclusions Possible explanations for discrepancies include different reference periods, lead-in statements, question format, and social desirability of responses. Choice of survey should depend on the hypothesis. If trends are necessary, choice of survey should not matter; however, if health status or expenditure associations are necessary, then surveys that contain these variables should be used, and if accurate overall estimates are necessary, then MEPS should be used. A validation study should be conducted to establish “true” utilization estimates. PMID:12036005

  12. Workplace Literacy: Business, Government, and Academic Perspectives. Panel Discussion.

    ERIC Educational Resources Information Center

    Malicky, Grace, Comp.; Dieleman, Carolyn; Campbell, Lloyd; Wong, Bill; Krahn, Harvey

    1998-01-01

    Presents highlights of a panel discussion on workplace literacy at the Literacy in the 21st Century Research Conference (Edmonton, Alberta, October 1997). Participants from business, government, and university discussed Syncrude Canada's Workplace Literacy Program, implications of the International Adult Literacy Survey for the labor market, and…

  13. State Special Education Advisory Panel Budgets. Quick Turn Around (QTA).

    ERIC Educational Resources Information Center

    Ahearn, Eileen M.

    The Individuals with Disabilities Education Act (IDEA) requires that each state education agency (SEA) establish and maintain an advisory panel for the purpose of providing policy guidance with respect to special education and related services for children with disabilities. This document is a brief summary of survey information received from 48…

  14. Workplace Literacy: Business, Government, and Academic Perspectives. Panel Discussion.

    ERIC Educational Resources Information Center

    Malicky, Grace, Comp.; Dieleman, Carolyn; Campbell, Lloyd; Wong, Bill; Krahn, Harvey

    1998-01-01

    Presents highlights of a panel discussion on workplace literacy at the Literacy in the 21st Century Research Conference (Edmonton, Alberta, October 1997). Participants from business, government, and university discussed Syncrude Canada's Workplace Literacy Program, implications of the International Adult Literacy Survey for the labor market, and…

  15. Panel Conditioning in a Longitudinal Study of Adolescents' Substance Use: Evidence from an Experiment

    ERIC Educational Resources Information Center

    Torche, Florencia; Warren, John Robert; Halpern-Manners, Andrew; Valenzuela, Eduardo

    2012-01-01

    Panel surveys are widely used in sociology to examine life-course trajectories and to assess causal effects. However, when using panel data researchers usually assume that the act of measuring respondents' attitudes and behaviors has no effect on the attributes being measured or on the accuracy of reports about those attributes. Evidence from…

  16. Panel Conditioning in a Longitudinal Study of Adolescents' Substance Use: Evidence from an Experiment

    ERIC Educational Resources Information Center

    Torche, Florencia; Warren, John Robert; Halpern-Manners, Andrew; Valenzuela, Eduardo

    2012-01-01

    Panel surveys are widely used in sociology to examine life-course trajectories and to assess causal effects. However, when using panel data researchers usually assume that the act of measuring respondents' attitudes and behaviors has no effect on the attributes being measured or on the accuracy of reports about those attributes. Evidence from…

  17. Returns to Education in Sri Lanka: A Pseudo-Panel Approach

    ERIC Educational Resources Information Center

    Himaz, Rozana; Aturupane, Harsha

    2016-01-01

    This study employs a pseudo-panel approach to estimate the returns to education among income earners in Sri Lanka. Pseudo-panel data are constructed from nine repeated cross sections of Sri Lanka's Labor Force Survey data from 1997 to 2008, for workers born during 1953-1974. The results show that for males, one extra year of education increases…

  18. What You Can--and Can't--Do with Three-Wave Panel Data

    ERIC Educational Resources Information Center

    Vaisey, Stephen; Miles, Andrew

    2017-01-01

    The recent change in the general social survey (GSS) to a rotating panel design is a landmark development for social scientists. Sociological methodologists have argued that fixed-effects (FE) models are generally the best starting point for analyzing panel data because they allow analysts to control for unobserved time-constant heterogeneity. We…

  19. Returns to Education in Sri Lanka: A Pseudo-Panel Approach

    ERIC Educational Resources Information Center

    Himaz, Rozana; Aturupane, Harsha

    2016-01-01

    This study employs a pseudo-panel approach to estimate the returns to education among income earners in Sri Lanka. Pseudo-panel data are constructed from nine repeated cross sections of Sri Lanka's Labor Force Survey data from 1997 to 2008, for workers born during 1953-1974. The results show that for males, one extra year of education increases…

  20. Aerospace Safety Advisory Panel

    NASA Astrophysics Data System (ADS)

    1989-03-01

    This report provides findings, conclusions and recommendations regarding the National Space Transportation System (NSTS), the Space Station Freedom Program (SSFP), aeronautical projects and other areas of NASA activities. The main focus of the Aerospace Safety Advisory Panel (ASAP) during 1988 has been monitoring and advising NASA and its contractors on the Space Transportation System (STS) recovery program. NASA efforts have restored the flight program with a much better management organization, safety and quality assurance organizations, and management communication system. The NASA National Space Transportation System (NSTS) organization in conjunction with its prime contractors should be encouraged to continue development and incorporation of appropriate design and operational improvements which will further reduce risk. The data from each Shuttle flight should be used to determine if affordable design and/or operational improvements could further increase safety. The review of Critical Items (CILs), Failure Mode Effects and Analyses (FMEAs) and Hazard Analyses (HAs) after the Challenger accident has given the program a massive data base with which to establish a formal program with prioritized changes.

  1. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This report provides findings, conclusions and recommendations regarding the National Space Transportation System (NSTS), the Space Station Freedom Program (SSFP), aeronautical projects and other areas of NASA activities. The main focus of the Aerospace Safety Advisory Panel (ASAP) during 1988 has been monitoring and advising NASA and its contractors on the Space Transportation System (STS) recovery program. NASA efforts have restored the flight program with a much better management organization, safety and quality assurance organizations, and management communication system. The NASA National Space Transportation System (NSTS) organization in conjunction with its prime contractors should be encouraged to continue development and incorporation of appropriate design and operational improvements which will further reduce risk. The data from each Shuttle flight should be used to determine if affordable design and/or operational improvements could further increase safety. The review of Critical Items (CILs), Failure Mode Effects and Analyses (FMEAs) and Hazard Analyses (HAs) after the Challenger accident has given the program a massive data base with which to establish a formal program with prioritized changes.

  2. Subjective Well-Being: Revisions to Dynamic Equilibrium Theory Using National Panel Data and Panel Regression Methods

    ERIC Educational Resources Information Center

    Headey, Bruce

    2006-01-01

    This paper partly revises the dynamic equilibrium (DE) theory of subjective well-being (SWB), sometimes termed set point theory. Results from four national panel surveys show that correlations among measures of SWB diminish over time, and that the SWB set points of a minority of individuals substantially change. These results mean that DE theory…

  3. 76 FR 32957 - Hydrographic Services Review Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-07

    ... National Oceanic and Atmospheric Administration Hydrographic Services Review Panel AGENCY: National Ocean... membership solicitation for Hydrographic Services Review Panel. SUMMARY: This notice responds to the... on the Hydrographic Services Review Panel (HSRP). The HSRP, a Federal advisory committee, advises the...

  4. Panelized wall system with foam core insulation

    DOEpatents

    Kosny, Jan [Oak Ridge, TN; Gaskin, Sally [Houston, TX

    2009-10-20

    A wall system includes a plurality of wall members, the wall members having a first metal panel, a second metal panel, and an insulating core between the first panel and the second panel. At least one of the first panel and the second panel include ridge portions. The insulating core can be a foam, such as a polyurethane foam. The foam can include at least one opacifier to improve the k-factor of the foam.

  5. Glass/Epoxy Door Panel for Automobiles

    NASA Technical Reports Server (NTRS)

    Bauer, J. L. JR.

    1985-01-01

    Lightweight panel cost-effective. Integrally-molded intrusion strap key feature of composite outer door panel. Strap replaces bulky and heavy steel instrusion beam of conventional door. Standard steel inner panel used for demonstration purposes. Door redesigned to exploit advantages of composite outer panel thinner. Outer panel for automobilie door, made of glass/epoxy composite material, lighter than conventional steel door panel, meets same strength requirements, and less expensive.

  6. Differing professional views or opinions: 1994 Special Review Panel

    SciTech Connect

    1996-09-01

    In July 1994, the Executive Director for Operations of the US Nuclear Regulatory Commission (NRC) appointed a Special Review Panel to assess the Differing Professional View or Opinion (DPV/DPO) process, including its effectiveness, how well it is understood by employees, and the organizational climate for having such views aired and properly decided. An additional area within this review was to address the effectiveness of the DPO procedures as they pertain to public access and confidentiality. Further, the Panel was charged with the review of the submittals completed since the last review to identify employees who made significant contributions to the agency or to the public health and safety but had not been adequately recognized for this contribution. The report presents the Special Review Panel`s evaluation of the NRC`s current process for dealing with Differing Professional Views or Opinions. Provided in this report are the results of an employee opinion survey on the process; highlights and suggestions from interviews with individuals who had submitted a Differing Professional View or Opinion, as well as with agency managers directly involved with the Differing Professional Views or Opinions process; and the Special Review Panel`s recommendations for improving the DPV/DPO process.

  7. AGU Sonar Data Restriction Panel

    NASA Astrophysics Data System (ADS)

    The AGU Council accepted the report of the panel set up in February to study the issue of restriction by the U.S. Navy of access to high-resolution sonar data for the U.S. Exclusive Economic Zone. Panel chairman John Bossier announced that “the Navy has acted in the best interests of the nation” in lifting the restriction order. Only two areas, egress routes to two submarine bases (see “Navy Defines Areas Under Sonar Ban,” in News, this issue), remain restricted.Panel members were Bruce Douglas, Alexander Malahoff, Donald Piepgras, Paul Richards, David Smith and Manik Talwani.

  8. Close up view of switchboard panel operator's station #1; panel ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close up view of switchboard panel operator's station #1; panel contains 1200 push-pull button switches which control poer to red, green, and white indicating lights on the model board; white lights indicate that power is off; green lights indicate that equipment (switch breaker or transformer) is off; red lights indicate that equipment is on - Thirtieth Street Station, Power Director Center, Thirtieth & Market Streets in Amtrak Railroad Station, Philadelphia, Philadelphia County, PA

  9. Space Launch System Panel Discussion

    NASA Image and Video Library

    2013-11-12

    Models of the Space Launch System and Orion spacecraft are displayed during a panel discussion on deep space eploration at the Newseum on Tuesday, November 12, 2013 in Washington. Photo Credit: (NASA/Jay Westcott)

  10. Exascale Workshop Panel Report Meeting

    SciTech Connect

    Khaleel, Mohammad A.

    2010-07-01

    The Exascale Review Panel consists of 12 scientists and engineers with experience in various aspects of high-performance computing and its application, development, and management. The Panel hear presentations by several representatives of the workshops and town meetings convened over the past few years to examine the need for exascale computation capability and the justification for a U.S. Department of Energy (DOE) program to develop such capability. This report summarizes information provided by the presenters and substantial written reports to the Panel in advance of the meeting in Washington D.C. on January 19-20, 2010. The report also summarizes the Panel's conclusions with regard to the justification of a DOE-led exascale initiative.

  11. PRSEUS Panel Fabrication Final Report

    NASA Technical Reports Server (NTRS)

    Linton, Kim A.; Velicki, Alexander; Hoffman, Krishna; Thrash, Patrick; Pickell, Robert; Turley, Robert

    2014-01-01

    NASA and the Boeing Company have been working together under the Environmentally Responsible Aviation Project to develop stitched unitized structure for reduced weight, reduced fuel burn and reduced pollutants in the next generation of commercial aircraft. The structural concept being evaluated is PRSEUS (Pultruded Rod Stitched Efficient Unitized Structure). In the PRSEUS concept, dry carbon fabric, pultruded carbon rods, and foam are stitched together into large preforms. Then these preforms are infused with an epoxy resin into large panels in an out-of-autoclave process. These panels have stiffeners in the length-wise and width-wise directions but contain no fasteners because all stiffeners are stitched to the panel skin. This document contains a description of the fabrication of panels for use in the 30-foot-long Multi-Bay Box test article to be evaluated at NASA LaRC.

  12. Thin film concentrator panel development

    NASA Technical Reports Server (NTRS)

    Zimmerman, D. K.

    1982-01-01

    The development and testing of a rigid panel concept that utilizes a thin film reflective surface for application to a low-cost point-focusing solar concentrator is discussed. It is shown that a thin film reflective surface is acceptable for use on solar concentrators, including 1500 F applications. Additionally, it is shown that a formed steel sheet substrate is a good choice for concentrator panels. The panel has good optical properties, acceptable forming tolerances, environmentally resistant substrate and stiffeners, and adaptability to low to mass production rates. Computer simulations of the concentrator optics were run using the selected reflector panel design. Experimentally determined values for reflector surface specularity and reflectivity along with dimensional data were used in the analysis. The simulations provided intercept factor and net energy into the aperture as a function of aperture size for different surface errors and pointing errors. Point source and Sun source optical tests were also performed.

  13. Panel to review EOSDIS plans

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Formed in Jan. 1992, the Panel to Review EOSDIS Plans was charged with advising NASA on its plans for developing the Earth Observing System (EOS) Data and Information System (EOSDIS). Specifically, the panel was asked to do the following: assess the validity of the engineering and technical underpinnings of the EOSDIS; assess its potential value to scientific users; suggest how technical risk can be minimized; and assess whether current plans are sufficiently resilient to be adaptable to changing technology and requirements such as budget environments, data volumes, new users, and new databases. The panel completed an interim report (Addendum A) and transmitted it to NASA and other interested parties in the government on 9 Apr. 1992. Because of a delay in NASA's plans to select the contractor for EOSDIS, the panel was not able to complete its review of the program according to the original government request. With the issuance of a letter report (Addendum B) on 28 Sep. 1992, the panel became inactive until such time as NASA could release the details of the contractor's proposed architecture, schedule, and costs for developing EOSDIS. In early 1993, NASA awarded the contract for the EOSDIS Core System (ECS). On 20 Apr. 1993, NASA asked the panel to reconvene to do the following: ( 1) complete its review of NASA's approach to the EOSDIS architecture and implementation; (2) appraise NASA's responses to the panel's previous recommendations; and (3) review the planning for EOSDIS in the context of NASA's role in the Global Change Data and Information System (GCDIS) implementation plan. To respond to the NASA charge, the panel met three times in 1993 including sessions with NASA officials and the EOSDIS contractor. In addition, several of the panel members visited individual Distributed Active Archive Centers (DAAC's) to obtain additional views of EOSDIS. The panel has now obtained substantial information on the EOSDIS budget, contractor work program, and current

  14. Two Thick Microwave Dichroic Panels

    NASA Technical Reports Server (NTRS)

    Epp, Larry W.; Chen, Jacqueline C.; Stanton, Philip H.; Jorgenson, Roy E.

    1994-01-01

    Cross-shaped apertures enable relatively tight packing, eliminating some grating lobes. Two panels made of thin, honey-comblike metal walls constitute planar arrays of waveguidelike apertures designed to satisfy special requirements with respect to microwave transmittance and reflectance. Considered for use in multiplexing signals at various frequencies in microwave communication system. Both panels required to exhibit low insertion loss. Angle of incidence 30 degrees.

  15. Two Thick Microwave Dichroic Panels

    NASA Technical Reports Server (NTRS)

    Epp, Larry W.; Chen, Jacqueline C.; Stanton, Philip H.; Jorgenson, Roy E.

    1994-01-01

    Cross-shaped apertures enable relatively tight packing, eliminating some grating lobes. Two panels made of thin, honey-comblike metal walls constitute planar arrays of waveguidelike apertures designed to satisfy special requirements with respect to microwave transmittance and reflectance. Considered for use in multiplexing signals at various frequencies in microwave communication system. Both panels required to exhibit low insertion loss. Angle of incidence 30 degrees.

  16. NDE of transparent protective panels

    NASA Astrophysics Data System (ADS)

    Barnard, Dan; Margetan, Frank J.; Chiou, C.-P.; Herman, Aaron; Pavel, Brittney; Chakrapani, Sunil K.

    2015-03-01

    In this paper we discuss nondestructive testing of five varieties of transparent armor panels fabricated from layers of glass, polymer and adhesive. The emphasis is on characterizing fabrication anomalies, such as lack of uniform layer thickness, rather than on damage detection. We report measurements of sound speed and attenuation on single-layer specimens of the polymer and the two types of glass used in the panels. We then discuss the results of various nondestructive studies of the panels, beginning with 225 KHz air-coupled ultrasonic testing (ACUT) and 5-MHz ultrasonic immersion testing. For all panels ultrasonic through-transmission C-scans reveal interesting patterns of signal amplitude and time-of-flight variations. These are traced to lateral changes in adhesive thickness within the panels. For one panel, adhesive sound speed, attenuation and density are deduced by analyzing UT immersion pulse/echo and pitch/catch data. Adhesive thickness variations manifest themselves differently in the two types of ultrasonic inspections. At the immersion inspection frequency adhesive attenuation dominates, so regions with thicker adhesive always have the smallest through-transmitted response. At ACUT frequencies reverberation echoes within the adhesive layer superimpose with echoes from other sound paths, and an increase in adhesive thickness can result in either an increase or decrease in through-transmitted amplitude. A simple model to account for such signal superposition is developed and found to be in qualitative agreement with the results of the ACUT inspections. The adhesive thickness variations cause the surfaces within the panel to be non-planar, leading to stresses on the various layers. We demonstrate the use of Terahertz-ray (T-ray) electromagnetic inspection to map the surface undulations of the thin glass outer layer in one of the panels. Bending stresses are estimated from the undulations and, at some locations, found to be at or near the levels that

  17. Stress-Simulating Witness Panels

    NASA Technical Reports Server (NTRS)

    Graham, Robert P.; Biegert, Lydia L.

    1995-01-01

    Special panel fixtures developed for verifying integrity of bonds between propellants and insulators in solid-fuel rocket motors by applying, to specimens of propellant and insulator material, stresses similar to those caused by shrinkage during fabrication of motors. Assemblies of fixtures and specimens called "stress-simulating witness panels." Concept also applicable to stress testing of bonds in other manufactured products subject to shrinkage or to swelling.

  18. JTEC panel report on advanced composites in Japan

    NASA Technical Reports Server (NTRS)

    Diefendorf, R. J.; Grisaffe, S. J.; Hillig, W. B.; Perepezko, J. H.; Pipes, R. B.; Sheehan, J. E.

    1991-01-01

    The JTEC Panel on Advanced Composites visited Japan and surveyed the status and future directions of Japanese high performance ceramic and carbon fibers and their composites in metal, intermetallic, ceramic and carbon matrices. The panel's interests included not only what composite systems were chosen, but also how these systems were developed. A strong carbon and fiber industry makes Japan the leader in carbon fiber technology. Japan has initiated an oxidation resistant carbon/carbon composite program. The goals for this program are ambitious, and it is just starting, but its progress should be closely monitored in the United States.

  19. Dust Accumulation on MER Solar Panels

    NASA Astrophysics Data System (ADS)

    Guinness, E. A.; Arvidson, R. E.; McEwen, A. S.; Cull, S.

    2011-12-01

    HiRISE acquired in March 2011 a color image of the Spirit Mars Exploration Rover from orbit that shows an exceptionally bright reflection from the rover solar panels. HiRISE data combined with laboratory measurements of MER solar cell reflectance provide a method for constraining the thickness of dust on the solar panels. Spirit is the brightest object in the HiRISE scene with a reflectance that is about 3 times higher at 500 nm and about 1.5 times higher at 700 and 850 nm than bright outcrop and soil near the rover. The rover is also less red than these nearby materials and less red than a typical Mars dust spectrum modeled with the same geometry and seen through similar atmospheric conditions as the HiRISE image. Lighting and viewing angles for the HiRISE image of Spirit are close to a specular reflection geometry when factoring in the rover orientation, the sun position, and the location of HiRISE during image acquisition. Laboratory photometric measurements of clean and dust-coated MER solar cells show a strong specular reflection for dust coating thicknesses up to at least 45 micrometers. The specular reflection was not present in the laboratory data when the solar cell was covered with about a 135 micrometer thick layer. The dust used in the experiments consisted of less than 10 micrometer sized particles derived from a palagonitic tephra from Mauna Kea that is spectrally similar to Mars dust. A survey of MER Pancam color images acquired by Spirit and Opportunity also shows several examples of specular reflections from the solar panels. These examples correspond to times when the solar cells were moderately clean to dusty as inferred from the amount of power generated by the cells. Specular reflections in Pancam images have been observed when the solar cell output was only 45% that of a dust-free cell. Spirit HiRISE data indicate that the rover was not covered by an optical thick layer of dust because some of the reflected light must have come from the

  20. Microextraction by Packed Sorbent (MEPS) and Solid-Phase Microextraction (SPME) as Sample Preparation Procedures for the Metabolomic Profiling of Urine

    PubMed Central

    Silva, Catarina; Cavaco, Carina; Perestrelo, Rosa; Pereira, Jorge; Câmara, José S.

    2014-01-01

    For a long time, sample preparation was unrecognized as a critical issue in the analytical methodology, thus limiting the performance that could be achieved. However, the improvement of microextraction techniques, particularly microextraction by packed sorbent (MEPS) and solid-phase microextraction (SPME), completely modified this scenario by introducing unprecedented control over this process. Urine is a biological fluid that is very interesting for metabolomics studies, allowing human health and disease characterization in a minimally invasive form. In this manuscript, we will critically review the most relevant and promising works in this field, highlighting how the metabolomic profiling of urine can be an extremely valuable tool for the early diagnosis of highly prevalent diseases, such as cardiovascular, oncologic and neurodegenerative ones. PMID:24958388

  1. Prevalence and Costs of Five Chronic Conditions in Children

    ERIC Educational Resources Information Center

    Miller, Gabrielle F.; Coffield, Edward; Leroy, Zanie; Wallin, Robin

    2016-01-01

    The objective is to examine the prevalence and health-care costs associated with asthma, epilepsy, hypertension, food allergies, and diabetes in children aged 0-18 years. Prevalence was calculated using 2005-2012 Medical Expenditure Panel Survey (MEPS) data, a population-based, nationally representative sample. Using MEPS, two-part models…

  2. Prevalence and Costs of Five Chronic Conditions in Children

    ERIC Educational Resources Information Center

    Miller, Gabrielle F.; Coffield, Edward; Leroy, Zanie; Wallin, Robin

    2016-01-01

    The objective is to examine the prevalence and health-care costs associated with asthma, epilepsy, hypertension, food allergies, and diabetes in children aged 0-18 years. Prevalence was calculated using 2005-2012 Medical Expenditure Panel Survey (MEPS) data, a population-based, nationally representative sample. Using MEPS, two-part models…

  3. Prevalence and determinants of metabolic syndrome: a cross-sectional survey of general medical outpatient clinics using National Cholesterol Education Program-Adult Treatment Panel III criteria in Botswana

    PubMed Central

    Omech, Bernard; Tshikuka, Jose-Gaby; Mwita, Julius C; Tsima, Billy; Nkomazana, Oathokwa; Amone-P’Olak, Kennedy

    2016-01-01

    Background Low- and middle-income countries, including Botswana, are facing rising prevalence of obesity and obesity-related cardiometabolic complications. Very little information is known about clustering of cardiovascular risk factors in the outpatient setting during routine visits. We aimed to assess the prevalence and identify the determinants of metabolic syndrome among the general outpatients’ attendances in Botswana. Methods A cross-sectional study was conducted from August to October 2014 involving outpatients aged ≥20 years without diagnosis of diabetes mellitus. A precoded questionnaire was used to collect data on participants’ sociodemographics, risk factors, and anthropometric indices. Fasting blood samples were drawn and analyzed for glucose and lipid profile. Metabolic syndrome was assessed using National Cholesterol Education Program-Adult Treatment Panel III criteria. Results In total, 291 participants were analyzed, of whom 216 (74.2%) were females. The mean age of the total population was 50.1 (±11) years. The overall prevalence of metabolic syndrome was 27.1% (n=79), with no significant difference between the sexes (female =29.6%, males =20%, P=0.11). A triad of central obesity, low high-density lipoprotein-cholesterol, and elevated blood pressure constituted the largest proportion (38 [13.1%]) of cases of metabolic syndrome, followed by a combination of low high-density lipoprotein, elevated triglycerides, central obesity, and elevated blood pressure, with 17 (5.8%) cases. Independent determinants of metabolic syndrome were antihypertensive use and increased waist circumference. Conclusion Metabolic syndrome is highly prevalent in the general medical outpatients clinics. Proactive approaches are needed to screen and manage cases targeting its most important predictors. PMID:27616893

  4. The temporal association of excessive health expenditure with suicidal ideation among primary income earners: a cross-sectional design using the Korean Welfare Panel Survey (KoWePS)

    PubMed Central

    Shin, Jaeyong; Choi, Jae Woo; Jang, Sung-in; Choi, Young; Lee, Sang Gyu; Ihm, Tae Hwan; Park, Eun-Cheol

    2015-01-01

    Objective Excessive health expenditure (EHE) is a global issue for households suffering from high-cost medical conditions, low incomes and limited insurance coverage. After the international financial crisis of 2008, EHE became a social problem in developed countries. Such economic crisis might induce severe mental stress, resulting in suicidal ideation. Methods We used the Korean Welfare Panel Study (KoWePS) from 2011 to 2013 and selected primary income earners, who were defined as practical and economic representatives of households; the total number of analysed samples was 4247 of 5717 households in the database. We only included households that had never experienced EHE before 2011. To examine the temporal relationship between EHE and suicidal ideation, we conducted a logistic regression analysis. Results Among 4247 participants, 146 (3.4%) experienced suicidal ideation, whereas 4101 (96.6%) did not. One scale of depression score (OR=1.28, CI 1.23 to 1.34, p<0.001) was associated with increased suicidal ideation. Such ideation was influenced to a greater extent by a recent EHE above 10% of disposable income (OR=1.91, CI 1.16 to 3.15, p=0.012) than by either a remote EHE (OR=1.29, CI 0.71 to 2.32) or one in 2011 and 2012 (OR=1.67, CI 1.01 to 2.78, p=0.048). Conclusions In this study, more recent EHE resulted in more suicidal ideation. In conclusion, we suggest that recent household EHE might be considered as an important factor to prevent suicidal ideation and to improve the mental health of individuals. PMID:26082463

  5. Easy Attachment Of Panels To A Truss

    NASA Technical Reports Server (NTRS)

    Thomson, Mark; Gralewski, Mark

    1992-01-01

    Conceptual antenna dish, solar collector, or similar structure consists of hexagonal panels supported by truss erected in field. Truss built in increments to maintain access to panel-attachment nodes. Each panel brought toward truss at angle and attached to two nodes. Panel rotated into attachment at third node.

  6. Easy Attachment Of Panels To A Truss

    NASA Technical Reports Server (NTRS)

    Thomson, Mark; Gralewski, Mark

    1992-01-01

    Conceptual antenna dish, solar collector, or similar structure consists of hexagonal panels supported by truss erected in field. Truss built in increments to maintain access to panel-attachment nodes. Each panel brought toward truss at angle and attached to two nodes. Panel rotated into attachment at third node.

  7. 14 CFR 1259.600 - Panel description.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Panel description. 1259.600 Section 1259... AND FELLOWSHIP PROGRAM Space Grant Review Panel § 1259.600 Panel description. An independent committee, the Space Grant Review Panel, which is not subject to the Federal Advisory Committee Act, shall...

  8. Panel established to revise position statement on climate change

    NASA Astrophysics Data System (ADS)

    President Robert Dickinson has appointed a panel to review the current AGU position statement on climate change and greenhouse gases, and to consider revising the statement to reflect scientific progress over the last four years. Marvin Geller of the State University of New York-Stonybrook chairs the panel.Other panel members include: Andre Berger, George Lemaître Catholic University of Louvain, Belgium; Anny Cazenave, Observatoire Midi-Pyrénées, Toulouse, France; John Christy, University of Alabama, Huntsville; Ellen Druffel, University of California, Irvine; Jack Fellows, University Consortium for Atmospheric Research, Boulder; Hiroshi Kanzawa, Nagoya University, Japan; William Schlesinger, Duke University, Durham; William (Jim) Shuttleworth, University of Arizona; Eric Sundquist, U.S. Geological Survey, Woods Hole; Richard Turco, University of California, Los Angeles; Ilana Wainer, Universidade Cidade Sao Paulo, Brazil.

  9. 6. Historic American Buildings Survey Courtesy of California Historical Society ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Courtesy of California Historical Society San Francisco, California Photo: ca. 1875 MIRROR PANELED BALLROOM - Ralston Hall, Ralston Avenue, Belmont, San Mateo County, CA

  10. 5. Historic American Buildings Survey Courtesy of California Historical Society ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey Courtesy of California Historical Society San Francisco, California Photo: ca. 1885 MIRROR PANELED BALLROOM - Ralston Hall, Ralston Avenue, Belmont, San Mateo County, CA

  11. High temperature structural sandwich panels

    NASA Astrophysics Data System (ADS)

    Papakonstantinou, Christos G.

    High strength composites are being used for making lightweight structural panels that are being employed in aerospace, naval and automotive structures. Recently, there is renewed interest in use of these panels. The major problem of most commercial available sandwich panels is the fire resistance. A recently developed inorganic matrix is investigated for use in cases where fire and high temperature resistance are necessary. The focus of this dissertation is the development of a fireproof composite structural system. Sandwich panels made with polysialate matrices have an excellent potential for use in applications where exposure to high temperatures or fire is a concern. Commercial available sandwich panels will soften and lose nearly all of their compressive strength temperatures lower than 400°C. This dissertation consists of the state of the art, the experimental investigation and the analytical modeling. The state of the art covers the performance of existing high temperature composites, sandwich panels and reinforced concrete beams strengthened with Fiber Reinforced Polymers (FRP). The experimental part consists of four major components: (i) Development of a fireproof syntactic foam with maximum specific strength, (ii) Development of a lightweight syntactic foam based on polystyrene spheres, (iii) Development of the composite system for the skins. The variables are the skin thickness, modulus of elasticity of skin and high temperature resistance, and (iv) Experimental evaluation of the flexural behavior of sandwich panels. Analytical modeling consists of a model for the flexural behavior of lightweight sandwich panels, and a model for deflection calculations of reinforced concrete beams strengthened with FRP subjected to fatigue loading. The experimental and analytical results show that sandwich panels made with polysialate matrices and ceramic spheres do not lose their load bearing capability during severe fire exposure, where temperatures reach several

  12. Postbuckling of laminated anisotropic panels

    NASA Technical Reports Server (NTRS)

    Jeffrey, Glenda L.

    1987-01-01

    A two-part study of the buckling and postbuckling of laminated anisotropic plates with bending-extensional coupling is presented. The first part involves the development and application of a modified Rayleigh-Ritz analysis technique. Modifications made to the classical technique can be grouped into three areas. First, known symmetries of anisotropic panels are exploited in the selection of approximation functions. Second, a reduced basis technique based on these same symmetries is applied in the linear range. Finally, geometric boundary conditions are enforced via an exterior penalty function approach, rather than relying on choice of approximation functions to satisfy these boundary conditions. Numerical results are presented for both the linear and nonlinear range, with additional studies made to determine the effect of variation in penalty parameter and number of basis vectors. In the second part, six panels possessing anisotropy and bending-extensional coupling are tested. Detailed comparisons are made between experiment and finite element results in order to gain insight into the postbuckling and failure characteristics of such panels. The panels are constructed using two different lamination sequences, and panels with three different aspect ratios were constructed for each lamination sequence.

  13. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature.

    PubMed

    Mongélard, Gaëlle; Seemann, Myriam; Boisson, Anne-Marie; Rohmer, Michel; Bligny, Richard; Rivasseau, Corinne

    2011-08-01

    The methylerythritol 4-phosphate (MEP) and the mevalonate pathways are the unique synthesis routes for the precursors of all isoprenoids. An original mean to measure the carbon flux through the MEP pathway in plants is proposed by using cadmium as a total short-term inhibitor of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate (MEcDP) reductase (GcpE) and measuring the accumulation rate of its substrate MEcDP by (31) P-NMR spectroscopy. The MEP pathway metabolic flux was determined in spinach (Spinacia oleracea), pea (Pisum sativum), Oregon grape (Mahonia aquifolium) and boxwood (Buxus sempervirens) leaves. In spinach, flux values were compared with the synthesis rate of major isoprenoids. The flux increases with light intensity (fourfold in the 200-1200 µmol m(-2) s(-1) PPFR range) and temperature (sevenfold in the 25-37 °C range). The relationship with the light and the temperature dependency of isoprenoid production downstream of the MEP pathway is discussed. © 2011 Blackwell Publishing Ltd.

  14. 7 CFR 1940.968 - Rural Economic Development Review Panel Grant (Panel Grant).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Rural Economic Development Review Panel Grant (Panel... of Certain Rural Development Programs § 1940.968 Rural Economic Development Review Panel Grant (Panel... associated with a State rural economic development review panel. (b) Objective. The objective of the...

  15. 5 CFR 2471.1 - Request for Panel consideration; request for Panel approval of binding arbitration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Request for Panel consideration; request for Panel approval of binding arbitration. 2471.1 Section 2471.1 Administrative Personnel FEDERAL... IMPASSES PANEL FEDERAL SERVICE IMPASSES PANEL PROCEDURES OF THE PANEL § 2471.1 Request for...

  16. Analysis of panel dent resistance

    NASA Technical Reports Server (NTRS)

    Ni, C. M.

    1976-01-01

    An analytical technique for elastic-plastic deformation of panels was developed, which is employed to analyze the denting mechanisms of panels resulting from point projectile impacts and impulsive loadings. The correlations of analytical results with the experimental measurements are considered quite satisfactory. The effect of elastic springback on the dent resistance analysis is found to be very significant for the panel (122 cm x 60.9 cm x 0.076 cm) subjected to a point projectile impact at 16.45 m/sec. While the amount of springback decreases as the loading speed increases, the effect due to the strain rate hardening of material, such as low carbon steel, becomes more dominant and is demonstrated in the analysis of dent resistance of a rectangular steel plate impulsively loaded.

  17. Panel perception of facial attractiveness.

    PubMed

    Kerr, W J; O'Donnell, J M

    1990-11-01

    The full-face and profile photographic transparencies of 60 subjects (30 male, 30 female) divided equally among Angles Class I, Class II Division 1, and Class III malocclusions, taken before and after orthodontic treatment, were randomly distributed in projector carousels and shown to four panels consisting of orthodontists, dental students, art students, and the parents of children undergoing orthodontic treatment. The faces were rated according to the method of Lundstrom et al. (1987). Full-face views generally were rated more attractive than profile views and Class II and Class III malocclusion subjects were rated lower than Class I malocclusion subjects. While the art student and parent panels were less critical in their appraisal of facial attractiveness, they were less sensitive to the changes brought about by orthodontic treatment than the orthodontist and dental student panels, although all could appreciate an improvement in the Class II Division 1 group.

  18. NO y Blue Ribbon panel

    NASA Astrophysics Data System (ADS)

    Crosley, David R.

    1996-01-01

    Total NOy was determined on the Pacific Exploratory Mission-West A using two separate instruments, one operated by Georgia Institute of Technology and one by Nagoya University. The two data sets exhibited significant disagreement, with no systematic correlation, and differences often a factor of 2 or more. Additionally, regardless of data set chosen, the total NOy was much greater than the sum of its components measured separately. A panel was convened by NASA in July 1993 to examine these conflicting datasets and the question of "missing NOy" on this mision. This paper reports the conclusions and recommendations from the panel.

  19. The "Virtual" Panel: A Computerized Model for LGBT Speaker Panels

    ERIC Educational Resources Information Center

    Beasley, Christopher; Torres-Harding, Susan; Pedersen, Paula J.

    2012-01-01

    Recent societal trends indicate more tolerance for homosexuality, but prejudice remains on college campuses. Speaker panels are commonly used in classrooms as a way to educate students about sexual diversity and decrease negative attitudes toward sexual diversity. The advent of computer-delivered instruction presents a unique opportunity to…

  20. The "Virtual" Panel: A Computerized Model for LGBT Speaker Panels

    ERIC Educational Resources Information Center

    Beasley, Christopher; Torres-Harding, Susan; Pedersen, Paula J.

    2012-01-01

    Recent societal trends indicate more tolerance for homosexuality, but prejudice remains on college campuses. Speaker panels are commonly used in classrooms as a way to educate students about sexual diversity and decrease negative attitudes toward sexual diversity. The advent of computer-delivered instruction presents a unique opportunity to…

  1. Solar panel truss mounting systems and methods

    DOEpatents

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2015-10-20

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  2. Solar panel truss mounting systems and methods

    DOEpatents

    Al-Haddad, Tristan Farris; Cavieres, Andres; Gentry, Russell; Goodman, Joseph; Nolan, Wade; Pitelka, Taylor; Rahimzadeh, Keyan; Brooks, Bradley; Lohr, Joshua; Crooks, Ryan; Porges, Jamie; Rubin, Daniel

    2016-06-28

    An exemplary embodiment of the present invention provides a solar panel truss mounting system comprising a base and a truss assembly coupled to the base. The truss assembly comprises a first panel rail mount, second panel rail mount parallel to the first panel rail mount, base rail mount parallel to the first and second panel rail mounts, and a plurality of support members. A first portion of the plurality of support members extends between the first and second panel rail mounts. A second portion of the plurality of support members extends between the first panel rail mount and the base rail mount. A third portion of the plurality of support members extends between the second panel rail mount and the base rail mount. The system can further comprise a plurality of connectors for coupling a plurality of photovoltaic solar panels to the truss assembly.

  3. Incorporating the sampling design in weighting adjustments for panel attrition

    PubMed Central

    Chen, Qixuan; Gelman, Andrew; Tracy, Melissa; Norris, Fran H.; Galea, Sandro

    2015-01-01

    We review weighting adjustment methods for panel attrition and suggest approaches for incorporating design variables, such as strata, clusters and baseline sample weights. Design information can typically be included in attrition analysis using multilevel models or decision tree methods such as the CHAID algorithm. We use simulation to show that these weighting approaches can effectively reduce bias in the survey estimates that would occur from omitting the effect of design factors on attrition while keeping the resulted weights stable. We provide a step-by-step illustration on creating weighting adjustments for panel attrition in the Galveston Bay Recovery Study, a survey of residents in a community following a disaster, and provide suggestions to analysts in decision making about weighting approaches. PMID:26239405

  4. Incorporating the sampling design in weighting adjustments for panel attrition.

    PubMed

    Chen, Qixuan; Gelman, Andrew; Tracy, Melissa; Norris, Fran H; Galea, Sandro

    2015-12-10

    We review weighting adjustment methods for panel attrition and suggest approaches for incorporating design variables, such as strata, clusters, and baseline sample weights. Design information can typically be included in attrition analysis using multilevel models or decision tree methods such as the chi-square automatic interaction detection algorithm. We use simulation to show that these weighting approaches can effectively reduce bias in the survey estimates that would occur from omitting the effect of design factors on attrition while keeping the resulted weights stable. We provide a step-by-step illustration on creating weighting adjustments for panel attrition in the Galveston Bay Recovery Study, a survey of residents in a community following a disaster, and provide suggestions to analysts in decision-making about weighting approaches. Copyright © 2015 John Wiley & Sons, Ltd.

  5. Determination of urinary levels of leukotriene B(4) using ad highly specific and sensitive methodology based on automatic MEPS combined with UHPLC-PDA analysis.

    PubMed

    Perestrelo, Rosa; Silva, Catarina L; Câmara, José S

    2015-11-01

    Leukotriene B4 (LTB4) is a potent mediator of inflammation and plays a key function in the pathophysiology of chronic asthma. Detectable urinary levels of LTB4, arises from the activation of leukotriene pathways. In this study an ultra-fast, selective and sensitive analytical method based on semi-automatic microextraction by packed sorbents (MEPS) technique, using a new digitally controlled syringe (eVol®) combined with ultra-high pressure liquid chromatography (UHPLC), is proposed for the measurement of urinary LTB4 (U-LTB4) levels in a group of asthmatic patients (APs) and healthy controls (CTRL). Important parameters affecting MEPS performance, namely sorbent type, number of extraction cycles (extract-discard) and elution volume, were evaluated. The optimal experimental conditions among those investigated for the quantification of U-LTB4 in urine samples were as follows: porous graphitic carbon sorbent (PGC), 10 extractions cycle (10×250 μL of sample) and LTB4 elution with 100 μL of acetonitrile. The UHPLC optimum conditions resulted in a mobile phase consisting of 95% (v/v) of acid aqueous solution (v/v), and acetonitrile 5% (v/v); flow rate of 500 µL/min, and a column temperature of 37±0.1 °C. Under optimized conditions the proposed method exhibit good selectivity and sensitivity LOD (0.37 ng/mL) and LOQ (1.22 ng/mL). The recovery ranging from 86.4 to 101.1% for LTB4, with relative standard deviations (% RSD) no larger than 5%. In addition, the method also afforded good results in terms of linearity (r(2)>0.995) within the established concentration range, with a residual deviation for each calibration point below 6%, and intra- and inter-day repeatability in urine samples with RSD values lower than 4 and 5%, respectively. The application of the method to urine samples revealed a tendency towards the increased urinary LTB4 levels in APs (5.42±0.17 ng/mL) when compared to those of CTRL group (from ND to 1.9 ng/mL). Urinary measurement of LTB4 may be an

  6. Space Launch System Panel Discussion

    NASA Image and Video Library

    2013-11-12

    Jim Crocker, Vice President and General Manager, civil space, Lockheed Martin Space Systems, gestures while speaking at a panel discussion on deep space exploration using the Space Launch System and Orion spacecraft at the Newseum in Washington on Tuesday, November 12, 2013. Photo Credit: (NASA/Jay Westcott)

  7. Peg supported thermal insulation panel

    DOEpatents

    Nowobilski, Jeffert J.; Owens, William J.

    1985-01-01

    A thermal insulation panel which is lightweight, load bearing, accommodates thermal stress, and has excellent high temperature insulation capability comprising high performance insulation between thin metal walls supported by high density, high strength glass pegs made in compliance with specified conditions of time, temperature and pressure.

  8. Peg supported thermal insulation panel

    DOEpatents

    Nowobilski, J.J.; Owens, W.J.

    1985-04-30

    A thermal insulation panel which is lightweight, load bearing, accommodates thermal stress, and has excellent high temperature insulation capability comprises high performance insulation between thin metal walls supported by high density, high strength glass pegs made in compliance with specified conditions of time, temperature and pressure. 2 figs.

  9. ASIST 2003: Part II: Panels.

    ERIC Educational Resources Information Center

    Proceedings of the ASIST Annual Meeting, 2003

    2003-01-01

    Forty-six panels address topics including women in information science; users and usability; information studies; reference services; information policies; standards; interface design; information retrieval; information networks; metadata; shared access; e-commerce in libraries; knowledge organization; information science theories; digitization;…

  10. ASIST 2003: Part II: Panels.

    ERIC Educational Resources Information Center

    Proceedings of the ASIST Annual Meeting, 2003

    2003-01-01

    Forty-six panels address topics including women in information science; users and usability; information studies; reference services; information policies; standards; interface design; information retrieval; information networks; metadata; shared access; e-commerce in libraries; knowledge organization; information science theories; digitization;…

  11. Improved radiographic image amplifier panel

    NASA Technical Reports Server (NTRS)

    Brown, R. L., Sr.

    1968-01-01

    Layered image amplifier for radiographic /X ray and gamma ray/ applications, combines very high radiation sensitivity with fast image buildup and erasure capabilities by adding a layer of material that is both photoconductive and light-emitting to basic image amplifier and cascading this assembly with a modified Thorne panel.

  12. Learning Physics with Physical Panels.

    ERIC Educational Resources Information Center

    Syurin, O.; Shulik, B.

    2000-01-01

    Presents two components of a piece of experimental equipment, the optical training ground and the electrical panel, which can be used to construct and test different electrical circuits and study laws of electricity, experimental problem solving, and basic light phenomena. (YDS)

  13. What Is Effectiveness? Panel Discussion.

    ERIC Educational Resources Information Center

    Zigmond, Naomi

    Two papers are presented from a panel discussion moderated by Naomi Zigmond, who introduces the papers with a note on definitions and measures of intervention effectiveness. "Some Thoughts on Effective Intervention for Handicapped Preschoolers," by Phillip Strain, notes that special education researchers attempt to be efficient, economical,…

  14. Risk-based decisionmaking (Panel)

    SciTech Connect

    Smith, T.H.

    1995-12-31

    By means of a panel discussion and extensive audience interaction, explore the current challenges and progress to date in applying risk considerations to decisionmaking related to low-level waste. This topic is especially timely because of the proposed legislation pertaining to risk-based decisionmaking and because of the increased emphasis placed on radiological performance assessments of low-level waste disposal.

  15. NAS Panel faults export controls

    NASA Astrophysics Data System (ADS)

    Katzoff, Judith A.

    A study prepared by a top-level panel says that current export controls on militarily sensitive U.S. technology may be “overcorrecting” previous weaknesses in that system, resulting in “a complex and confusing control system” that makes it more difficult for U.S. businesses to compete in international markets. Moreover, this control system has “an increasingly corrosive effect” on U.S. relations with allies. The panel recommended that the United States concentrate more effort on bringing about uniformity in the export control policies of countries belonging to the Coordinating Committee on Multilateral Export Controls (CoCom), i.e., most of the member nations in NATO (the North Atlantic Treaty Organization) and Japan.The 21-member panel was appointed by the Committee on Science, Engineering, and Public Policy (COSEPUP), a joint unit of the National Academy of Sciences (NAS), the National Academy of Engineering (NAE), and the Institute of Medicine (IOM). The panel, composed of administrators, researchers, and former government officials, was chaired by AGU member Lew Allen, Jr., director of the Jet Propulsion Laboratory (Pasadena, Calif.) and former chief of staff of the U.S. Air Force. Their report was supported by NAS funds, by a number of private organizations (including AGU), by the U.S. Departments of Commerce, Defense, Energy, and State, by the National Science Foundation, and by the National Aeronautics and Space Administration.

  16. High temperature be panel development

    NASA Technical Reports Server (NTRS)

    Hardesty, R.; Jensen, M.; Grant, L.

    1989-01-01

    Beryllium materials have been used for many aerospace applications over the years. Most of these applications have been fairly ambient environments. The possibility of fabricating beryllium panels for high temperature applications up to 1200 F is investigated. Joining alloys were reviewed, tested and evaluated for high temperature applications.

  17. Panel: RFID Security and Privacy

    NASA Astrophysics Data System (ADS)

    Fu, Kevin

    The panel on RFID security and privacy included Ross Anderson, Jon Callas, Yvo Desmedt, and Kevin Fu. Topics for discussion included the "chip and PIN" EMV payment systems, e-Passports, "mafia" attacks, and RFID-enabled credit cards. Position papers by the panelists appear in the following pages, and the RFID-enabled credit card work appears separately in these proceedings.

  18. Expert Panels, Consumers, and Chemistry.

    ERIC Educational Resources Information Center

    Rehfeldt, Thomas K.

    2000-01-01

    Studied the attributes, properties, and consumer acceptance of antiperspirant products through responses of 400 consumers (consumer data), expert panel data, and analytical data about the products. Results show how the Rasch model can provide the tool necessary to combine data from several sources. (SLD)

  19. Humid free efficient solar panel

    NASA Astrophysics Data System (ADS)

    Panjwani, Manoj Kumar; Panjwani, Suresh Kumar; Mangi, Fareed Hussain; Khan, Danish; Meicheng, Li

    2017-09-01

    The paper examines the impact of the humidity on the Solar panels which makes a space for the drastic variation in the power generated and makes the device less efficient. Humidity readily affects the efficiency of the solar cells and creates a minimal layer of water on its surface. It also decreases the efficiency by 10-20% of the total power output produced. Moreover, to handle this issue, all around characterized measures are required to be taken to guarantee the smooth working of the solar panels utilized in humid areas. In connection with this issue, Karachi, the biggest city of Pakistan which is located near the costal line touching Arabian Sea, was taken as a reference city to measure the humidity range. In Karachi, the average humidity lies between 25-70% (as per Pakistan Meteorological Department PMD), that indirectly leads in decreasing power acquired from a Solar Panel and develops various complexities for the solar system. The system on average experiences stability issues, such as those of power fluctuations etc., due to which, the whole solar system installed observes abnormal variations in acquired power. Silica Gel was used as a desiccant material in order to assure dryness over the solar panel. More than four experiments were conducted with the usage of water absorbent to improve the efficiency and to make system more power efficient.

  20. PANEL CODE FOR PLANAR CASCADES

    NASA Technical Reports Server (NTRS)

    Mcfarland, E. R.

    1994-01-01

    The Panel Code for Planar Cascades was developed as an aid for the designer of turbomachinery blade rows. The effective design of turbomachinery blade rows relies on the use of computer codes to model the flow on blade-to-blade surfaces. Most of the currently used codes model the flow as inviscid, irrotational, and compressible with solutions being obtained by finite difference or finite element numerical techniques. While these codes can yield very accurate solutions, they usually require an experienced user to manipulate input data and control parameters. Also, they often limit a designer in the types of blade geometries, cascade configurations, and flow conditions that can be considered. The Panel Code for Planar Cascades accelerates the design process and gives the designer more freedom in developing blade shapes by offering a simple blade-to-blade flow code. Panel, or integral equation, solution techniques have been used for several years by external aerodynamicists who have developed and refined them into a primary design tool of the aircraft industry. The Panel Code for Planar Cascades adapts these same techniques to provide a versatile, stable, and efficient calculation scheme for internal flow. The code calculates the compressible, inviscid, irrotational flow through a planar cascade of arbitrary blade shapes. Since the panel solution technique is for incompressible flow, a compressibility correction is introduced to account for compressible flow effects. The analysis is limited to flow conditions in the subsonic and shock-free transonic range. Input to the code consists of inlet flow conditions, blade geometry data, and simple control parameters. Output includes flow parameters at selected control points. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 590K of 8 bit bytes. This program was developed in 1982.

  1. Using a Standing Poll Panel To Monitor the Pulse of the Campus. AIR 1992 Annual Forum Paper.

    ERIC Educational Resources Information Center

    Cash, R. William

    This paper discusses the results of a randomly selected standing poll panel implemented at Saint Mary's College at Notre Dame, Indiana, called PRISM (Prompt Response to Improve Saint Mary's). PRISM is designed to quickly ascertain the attitudes and opinions of a panel of 120 college students. Sample topics of PRISM surveys have included campus…

  2. Molecular structure, vibrational, UV, NMR, HOMO-LUMO, MEP, NLO, NBO analysis of 3,5 di tert butyl 4 hydroxy benzoic acid

    NASA Astrophysics Data System (ADS)

    Mathammal, R.; Sangeetha, K.; Sangeetha, M.; Mekala, R.; Gadheeja, S.

    2016-09-01

    In this study, we report a combined experimental and theoretical study on molecular structure and vibrational spectra of 3,5 di tert butyl 4 hydroxy benzoic acid. The properties of title compound have been evaluated by quantum chemical calculation (DFT) using B3LYP functional and 6-31 + G (d, p) as basis set. IR Spectra has been recorded using Fourier transform infrared spectroscopy (FT-IR) in the region 4000-400 cm-1. The vibrational assignment of the calculated normal modes has been made on the basis set. The isotropic chemical shifts computed by 13C and 1H NMR (Nuclear Magnetic Resonance) analyses also show good agreement with experimental observations. The theoretical UV-Vis spectrum of the compound are used to study the visible absorption maxima (λ max). The structure activity relationship have been interpreted by mapping electrostatic potential surface (MEP), which is valuable information for the quality control of medicines and drug receptor interactions. The Mullikan charges, HOMO (Highest Occupied Molecular Orbital) - LUMO (Lowest Unoccupied Molecular Orbital) energy are analyzed. HOMO-LUMO energy gap and other related molecular properties are also calculated. The Natural Bond Orbital (NBO) analysis is carried out to investigate the various intra and inter molecular interactions of molecular system. The Non-linear optical properties such as dipole moment (μ), polarizability (αtot) and molecular first order hyperpolarizability (β) of the title compound are computed with B3LYP/6-31 + G (d,p) level of theory.

  3. Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway

    PubMed Central

    Hui, Xian; Yue, Qiao; Zhang, Dan-Dan; Li, Heng; Yang, Shao-Qing; Gao, Wen-Yun

    2016-01-01

    1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is the first committed enzyme in the 2-methyl-D-erythritol 4-phosphate (MEP) terpenoid biosynthetic pathway and is also a validated antimicrobial target. Theaflavins, which are polyphenolic compounds isolated from fermented tea, possess a wide range of pharmacological activities, especially an antibacterial effect, but little has been reported on their modes of antimicrobial action. To uncover the antibacterial mechanism of theaflavins and to seek new DXR inhibitors from natural sources, the DXR inhibitory activity of theaflavins were investigated in this study. The results show that all four theaflavin compounds could specifically suppress the activity of DXR, with theaflavin displaying the lowest effect against DXR (IC50 162.1 μM) and theaflavin-3,3′-digallate exhibiting the highest (IC50 14.9 μM). Moreover, determination of inhibition kinetics of the theaflavins demonstrates that they are non-competitive inhibitors of DXR against 1-deoxy-D-xylulose 5-phosphate (DXP) and un-competitive inhibitors with respect to NADPH. The possible interactions between DXR and the theaflavins were simulated via docking experiments. PMID:27941853

  4. Inhibition of green tea and the catechins against 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway.

    PubMed

    Hui, Xian; Liu, Hui; Tian, Fang-Lin; Li, Fei-Fei; Li, Heng; Gao, Wen-Yun

    2016-09-01

    1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) is the first committed enzyme in the MEP terpenoid biosynthetic pathway and also a validated antimicrobial target. Green tea which is rich in polyphenolic components such as the catechins, possesses a plenty of pharmacological activities, in particular an antibacterial effect. To uncover the antibacterial mechanism of green tea and to seek new DXR inhibitors from natural sources, the DXR inhibitory activity of green tea and its main antimicrobial catechins were investigated in this study. The results show that the raw extract of green tea and its ethyl acetate fraction are able to suppress DXR activity explicitly. Further determination of the DXR inhibitory capacity of eight catechin compounds demonstrates that the most active compound is gallocatechin gallate that is able to inhibit around 50% activity of DXR at 25μM. Based on these data, the primary structure-activity relationship of the catechins against DXR is discussed. This study would be very helpful to elucidate the antimicrobial mechanism of green tea and the catechins and also would be very useful to direct the rational utilization of them as food additives.

  5. Molecular structure, vibrational spectra, NLO and MEP analysis of bis[2-hydroxy-кO-N-(2-pyridyl)-1-naphthaldiminato-кN]zinc(II)

    NASA Astrophysics Data System (ADS)

    Tanak, Hasan; Toy, Mehmet

    2013-11-01

    The molecular geometry and vibrational frequencies of bis[2-hydroxy-кO-N-(2-pyridyl)-1-naphthaldiminato-кN]zinc(II) in the ground state have been calculated by using the Hartree-Fock (HF) and density functional method (B3LYP) with 6-311G(d,p) basis set. The results of the optimized molecular structure are presented and compared with the experimental X-ray diffraction. The energetic and atomic charge behavior of the title compound in solvent media has been examined by applying the Onsager and the polarizable continuum model. To investigate second order nonlinear optical properties of the title compound, the electric dipole (μ), linear polarizability (α) and first-order hyperpolarizability (β) were computed using the density functional B3LYP and CAM-B3LYP methods with the 6-31+G(d) basis set. According to our calculations, the title compound exhibits nonzero (β) value revealing second order NLO behavior. In addition, DFT calculations of the title compound, molecular electrostatic potential (MEP), frontier molecular orbitals, and thermodynamic properties were performed at B3LYP/6-311G(d,p) level of theory.

  6. Analytical Profiling of Bioactive Phenolic Compounds in Argan (Argania spinosa) Leaves by Combined Microextraction by Packed Sorbent (MEPS) and LC-DAD-MS/MS.

    PubMed

    Mercolini, Laura; Protti, Michele; Saracino, Maria Addolorata; Mandrone, Manuela; Antognoni, Fabiana; Poli, Ferruccio

    2016-01-01

    The argan tree (Argania spinosa) is an endemic species from south-western Morocco. Argan-based preparations have been widely used in Moroccan traditional medicine for their biological properties, as well as for several cosmetic purposes. Whereas kernel, pulp of fruit and trunk have been extensively studied for their nutritional and pharmacological effects, relatively little is known about argan tree leaves. The main purpose of the present study is to investigate and characterise the bioactive phenolic fractions in both crude and aqueous extracts derived from argan tree leaves. A qualitative profile of the antioxidant phenolic compounds in argan leaves was obtained by means of structural hypothesis based on UV spectra and mass spectrometric fragmentation patterns. Moreover, selected phenolics were quantified in argan leaves by using a fully validated method based on liquid chromatography coupled to diode array detection and tandem mass spectrometry (LC-DAD-MS/MS). All the extracts were purified by a fast and reliable microextraction by packed sorbent (MEPS) procedure, before analysing them by LC-MS/MS. Based on retention times, mass spectrometric fragmentation and UV spectra, 13 phenolic compounds were identified or tentatively elucidated from crude and aqueous extracts derived from Argania spinosa leaves, while seven compounds were quantified in both extracts. The obtained results could represent a first step towards a complete characterisation of the argan plant, its bioactive profiling and the valorisation of its by-products as a source of potentially beneficial bioactive molecules. Copyright © 2015 John Wiley & Sons, Ltd.

  7. An animal homolog of plant Mep/Amt transporters promotes ammonia excretion by the anal papillae of the disease vector mosquito Aedes aegypti.

    PubMed

    Chasiotis, Helen; Ionescu, Adrian; Misyura, Lidiya; Bui, Phuong; Fazio, Kimberly; Wang, Jason; Patrick, Marjorie; Weihrauch, Dirk; Donini, Andrew

    2016-05-01

    The transcripts of three putative ammonia (NH3/NH4 (+)) transporters, Rhesus-like glycoproteins AeRh50-1, AeRh50-2 and Amt/Mep-like AeAmt1 were detected in the anal papillae of larval Aedes aegypti Quantitative PCR studies revealed 12-fold higher transcript levels of AeAmt1 in anal papillae relative to AeRh50-1, and levels of AeRh50-2 were even lower. Immunoblotting revealed AeAmt1 in anal papillae as a pre-protein with putative monomeric and trimeric forms. AeAmt1 was immunolocalized to the basal side of the anal papillae epithelium where it co-localized with Na(+)/K(+)-ATPase. Ammonium concentration gradients were measured adjacent to anal papillae using the scanning ion-selective electrode technique (SIET) and used to calculate ammonia efflux by the anal papillae. dsRNA-mediated reductions in AeAmt1 decreased ammonia efflux at larval anal papillae and significantly increased ammonia levels in hemolymph, indicating a principal role for AeAmt1 in ammonia excretion. Pharmacological characterization of ammonia transport mechanisms in the anal papillae suggests that, in addition to AeAmt1, the ionomotive pumps V-type H(+)-ATPase and Na(+)/K(+)-ATPase as well as NHE3 are involved in ammonia excretion at the anal papillae.

  8. Molecular structure, vibrational spectra, NLO and MEP analysis of bis[2-hydroxy-кO-N-(2-pyridyl)-1-naphthaldiminato-кN]zinc(II).

    PubMed

    Tanak, Hasan; Toy, Mehmet

    2013-11-01

    The molecular geometry and vibrational frequencies of bis[2-hydroxy-кO-N-(2-pyridyl)-1-naphthaldiminato-кN]zinc(II) in the ground state have been calculated by using the Hartree-Fock (HF) and density functional method (B3LYP) with 6-311G(d,p) basis set. The results of the optimized molecular structure are presented and compared with the experimental X-ray diffraction. The energetic and atomic charge behavior of the title compound in solvent media has been examined by applying the Onsager and the polarizable continuum model. To investigate second order nonlinear optical properties of the title compound, the electric dipole (μ), linear polarizability (α) and first-order hyperpolarizability (β) were computed using the density functional B3LYP and CAM-B3LYP methods with the 6-31+G(d) basis set. According to our calculations, the title compound exhibits nonzero (β) value revealing second order NLO behavior. In addition, DFT calculations of the title compound, molecular electrostatic potential (MEP), frontier molecular orbitals, and thermodynamic properties were performed at B3LYP/6-311G(d,p) level of theory. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Retaining Ring Fastener for Solar Panels

    NASA Technical Reports Server (NTRS)

    Wilson, A. H.

    1983-01-01

    Simple articulating linkage secures solar panels into supporting framework. Five element linkage collapses into W-shape for easy placement into framework, then expands to form rectangle of same dimensions as those of panel.

  10. Blue Ribbon Panel 2016 Video Playlist

    Cancer.gov

    Blue Ribbon Panel members discuss recommendations from the panel report that was presented to the National Cancer Advisory Board. The playlist includes an overview video and 10 videos on the specific recommendations.

  11. Installation package for concentrating solar collector panels

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The concentrating solar collector panels comprise a complete package array consisting of collector panels using modified Fresnel prismatic lenses for a 10 to 1 concentrating ratio, supporting framework, fluid manifolding and tracking drive system, and unassembled components for field erection.

  12. Acoustic testing of high temperature panels

    NASA Technical Reports Server (NTRS)

    Leatherwood, Jack D.; Clevenson, Sherman A.; Powell, Clemans A.; Daniels, Edward F.

    1990-01-01

    Results are presented of a series of thermal-acoustic tests conducted on the NASA Langley Research Center Thermal-Acoustic Test Apparatus to (1) investigate techniques for obtaining strain measurements on metallic and carbon-carbon materials at elevated temperature; (2) document the dynamic strain response characteristics of several superalloy honeycomb thermal protection system panels at elevated temperatures of up to 1200 F; and (3) determine the strain response and sonic fatigue behavior of four carbon-carbon panels at both ambient and elevated temperatures. A second study tested four carbon-carbon panels to document panel dynamic response characteristics at ambient and elevated temperature, determine time to failure and faliure modes, and collect continuous strain data up to panel failure. Strain data are presented from both types of panels, and problems encountered in obtaining reliable strain data on the carbon-carbon panels are described. The failure modes of the carbon-carbon panels are examined.

  13. Retaining Ring Fastener for Solar Panels

    NASA Technical Reports Server (NTRS)

    Wilson, A. H.

    1983-01-01

    Simple articulating linkage secures solar panels into supporting framework. Five element linkage collapses into W-shape for easy placement into framework, then expands to form rectangle of same dimensions as those of panel.

  14. Silicone-Rubber Tooling for Hollow Panels

    NASA Technical Reports Server (NTRS)

    Gallimore, F. H.

    1985-01-01

    Wave-free contour surface obtained by using flexible mold. Silicone-rubber layup tool, when used in conjunction with hard plastic laminating mold defining desired contour, produces panel with wave-free surface that accurately reproduces shape of mold. In addition to providing porous hollow-panel wing structure that acts as duct for transporting sucked boundary layer tooling, also used to fabricate high-strength lightweight door panels and any single-or compound-contour panel.

  15. Lightweight composites for modular panelized construction

    NASA Astrophysics Data System (ADS)

    Vaidya, Amol S.

    Rapid advances in construction materials technology have enabled civil engineers to achieve impressive gains in the safety, economy, and functionality of structures built to serve the common needs of society. Modular building systems is a fast-growing modern, form of construction gaining recognition for its increased efficiency and ability to apply modern technology to the needs of the market place. In the modular construction technique, a single structural panel can perform a number of functions such as providing thermal insulation, vibration damping, and structural strength. These multifunctional panels can be prefabricated in a manufacturing facility and then transferred to the construction site. A system that uses prefabricated panels for construction is called a "panelized construction system". This study focuses on the development of pre-cast, lightweight, multifunctional sandwich composite panels to be used for panelized construction. Two thermoplastic composite panels are proposed in this study, namely Composite Structural Insulated Panels (CSIPs) for exterior walls, floors and roofs, and Open Core Sandwich composite for multifunctional interior walls of a structure. Special manufacturing techniques are developed for manufacturing these panels. The structural behavior of these panels is analyzed based on various building design codes. Detailed descriptions of the design, cost analysis, manufacturing, finite element modeling and structural testing of these proposed panels are included in this study in the of form five peer-reviewed journal articles. The structural testing of the proposed panels involved in this study included flexural testing, axial compression testing, and low and high velocity impact testing. Based on the current study, the proposed CSIP wall and floor panels were found satisfactory, based on building design codes ASCE-7-05 and ACI-318-05. Joining techniques are proposed in this study for connecting the precast panels on the construction

  16. Thermal-structural panel buckling tests

    NASA Technical Reports Server (NTRS)

    Thompson, Randolph C.; Richards, W. Lance

    1991-01-01

    The buckling characteristics of a titanium matrix composite hat-stiffened panel were experimentally examined for various combinations of thermal and mechanical loads. Panel failure was prevented by maintaining the applied loads below real-time critical buckling predictions. The test techniques used to apply the loads, minimize boundary were shown to compare well with a finite-element buckling analysis for previous panels. Comparisons between test predictions and analysis for this panel are ongoing.

  17. 76 FR 56242 - Meetings of Humanities Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... THE ARTS AND THE HUMANITIES Meetings of Humanities Panel AGENCY: The National Endowment for the Humanities, The National Foundation on the Arts and the Humanities. ACTION: Cancellation of panel meeting. Notice is hereby given of the cancellation of the following meeting of the Humanities Panel at the Old...

  18. 30 CFR 77.310 - Control panels.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES Thermal Dryers § 77.310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... posted on or near the control panel of each thermal drying system. (c) Each instrument on the control...

  19. 30 CFR 77.310 - Control panels.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... each thermocouple, pressure tap, or other control or gaging instrument in the drying system shall be...

  20. 30 CFR 77.310 - Control panels.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Control panels. 77.310 Section 77.310 Mineral....310 Control panels. (a) All thermal dryer system control panels constructed after June 30, 1971 shall... each thermocouple, pressure tap, or other control or gaging instrument in the drying system shall be...

  1. 32 CFR 724.103 - NDRB panel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false NDRB panel. 724.103 Section 724.103 National... Definitions § 724.103 NDRB panel. An element of the NDRB, consisting of five members, authorized to review discharges. In plenary review session, an NDRB panel acts with the authority delegated by the Secretary...

  2. 78 FR 5184 - Special Emphasis Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... HUMAN SERVICES Agency for Healthcare Research and Quality Special Emphasis Panel Meeting AGENCY: Agency... Healthcare Research and Quality (AHRQ) Special Emphasis Panel (SEP) meeting on ``Patient Centered Outcomes... INFORMATION: A Special Emphasis Panel is a group of experts in fields related to health care research who...

  3. 38 CFR 19.11 - Reconsideration panel.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Reconsideration panel. 19... Reconsideration panel. (a) Assignment of Members. When a motion for reconsideration is allowed, the Chairman will assign a panel of three or more Members of the Board, which may include the Chairman, to conduct...

  4. A Comparison of Several Techniques For Estimating The Average Volume Per Acre For Multipanel Data With Missing Panels

    Treesearch

    Dave Gartner; Gregory A. Reams

    2001-01-01

    As Forest Inventory and Analysis changes from a periodic survey to a multipanel annual survey, a transition will occur where only some of the panels have been resurveyed. Several estimation techniques use data from the periodic survey in addition to the data from the partially completed multipanel data. These estimation techniques were compared using data from two...

  5. ASAP Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is the First Quarterly Report for the newly reconstituted Aerospace Safety Advisory Panel (ASAP). The NASA Administrator rechartered the Panel on November 18,2003, to provide an independent, vigilant, and long-term oversight of NASA's safety policies and programs well beyond Return to Flight of the Space Shuttle. The charter was revised to be consistent with the original intent of Congress in enacting the statute establishing ASAP in 1967 to focus on NASA's safety and quality systems, including industrial and systems safety, risk-management and trend analysis, and the management of these activities.The charter also was revised to provide more timely feedback to NASA by requiring quarterly rather than annual reports, and by requiring ASAP to perform special assessments with immediate feedback to NASA. ASAP was positioned to help institutionalize the safety culture of NASA in the post- Stafford-Covey Return to Flight environment.

  6. ASAP Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This is the First Quarterly Report for the newly reconstituted Aerospace Safety Advisory Panel (ASAP). The NASA Administrator rechartered the Panel on November 18,2003, to provide an independent, vigilant, and long-term oversight of NASA's safety policies and programs well beyond Return to Flight of the Space Shuttle. The charter was revised to be consistent with the original intent of Congress in enacting the statute establishing ASAP in 1967 to focus on NASA's safety and quality systems, including industrial and systems safety, risk-management and trend analysis, and the management of these activities.The charter also was revised to provide more timely feedback to NASA by requiring quarterly rather than annual reports, and by requiring ASAP to perform special assessments with immediate feedback to NASA. ASAP was positioned to help institutionalize the safety culture of NASA in the post- Stafford-Covey Return to Flight environment.

  7. Panel 4 - applications to transportation

    SciTech Connect

    Nichols, F.; Au, J.; Bhattacharya, R.; Bhushan, B.; Blunier, D.; Boardman, B.; Brombolich, L.; Davidson, J.; Graham, M.; Hakim, N.; Harris, K.; Hay, R.; Herk, L.; Hojnacki, H.; Rourk, D.; Kamo, R.; Nieman, B.; O`Neill, D.; Peterson, M.B.; Pfaffenberger, G.; Pryor, R.W.; Russell, J.; Syniuta, W.; Tamor, M.; Vojnovich, T.; Yarbrough, W.; Yust, C.S.

    1993-01-01

    The aim of this group was to compile a listing of current and anticipated future problem areas in the transportation industry where the properties of diamond and DLC films make them especially attractive and where the panel could strongly endorse the establishment of DOE/Transportation Industry cooperative research efforts. This section identifies the problem areas for possible applications of diamond/DLC technology and presents indications of current approaches to these problems.

  8. Flat panel planar optic display

    SciTech Connect

    Veligdan, J.T.

    1994-11-01

    A prototype 10 inch flat panel Planar Optic Display, (POD), screen has been constructed and tested. This display screen is comprised of hundreds of planar optic class sheets bonded together with a cladding layer between each sheet where each glass sheet represents a vertical line of resolution. The display is 9 inches wide by 5 inches high and approximately 1 inch thick. A 3 milliwatt HeNe laser is used as the illumination source and a vector scanning technique is employed.

  9. Emissions and Noise Pervasive Panel

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda; Lee, Chi

    2008-01-01

    Objectives include: Provide interagency coordination of technology development, aimed at engine noise reduction. a) Provide recommendations to the Steering Committee on potential areas of interagency technology collaboration to maximize the use of government investments in noise reduction. b) Serve as a forum for information and technology exchange in order to coordinate gas turbine engine environmental strategies and policies among the member agencies and industry; c) Coordinate activities across panel representatives; and d) Communicate progress to VAATE steering committee.

  10. Final Panel Report on Allergenics

    Center for Biologics Evaluation and Research (CBER)

    ... It il;l J:l'1t! op:i.qion .o;th~ Panel t.ha,t t;h~r~. is non~w ra:v:l,cl~;nC7~i!, to sug~~t;:I,t ,that proc~~~gq ~u+l?at;r~~e :$,ou;r~~ Qt.sp,e~ira!3~P,~};f:f,Jc ...

  11. Panel urges cloning ethics boards

    SciTech Connect

    Marshall, E.

    1997-01-03

    A 7-month review of the system that guides U.S. policy on the ethical, legal, and social issues (ELSI) of the Human Genome Project has concluded that it is time for a radical overhaul. A report completed last month recommends that a high-level policy board be created in the office of the Secretary of Health and Human Services to help develop policies on such sensitive issues as genetic privacy, antidiscrimination legislation, public education on genetic risks, and the regulation of genetic testing. If accepted, the proposal-from a review panel chaired by attorney Mark Rothstein of the University of Houston and geneticist M. Anne Spence of the University of California, Irvine-would create a new panel of 15 to 18 members to serve as {open_quotes}a public forum for discussion of ... critical issues.{close_quotes} This panel would replace the current advisory body, known as the ELSI Working Group, and end what the report calls a {open_quotes}discordance{close_quotes} between the broad scope of the Working Group and the {open_quotes}very limited focus{close_quotes} of the research program under which it operates.

  12. Panel labels extraction from multi-panel figures for facilitating multi-modal information retrieval

    NASA Astrophysics Data System (ADS)

    Ali, Mushtaq; Dong, Le; Liang, Yan; He, Ling; Feng, Ning

    2015-07-01

    The association of subfigures in the multi-panel figure with related text in the accompanying caption and research article is necessary for the implementation of multi-modal information retrieval system. The panel labels in the multipanel figure are used as a source for making this kind of association. In this paper, we propose a novel method for the detection of panel labels in the multi-panel figures. The proposed method uses segmentation of multi-panel figure and its accompanying caption into subfigures and sub captions, respectively, as a preprocessing step. Next, the features of panel label, i.e., area and its distance from the borders in the upper left most subfigure of the multi panel figure are computed. These features are then used for detecting panel labels located in the rest of subfigures of the same multi-panel figure. Experiments on multi-panel figures selected from imageCLEF2013 dataset show promising results.

  13. High Efficiency, High Density Terrestrial Panel. [for solar cell modules

    NASA Technical Reports Server (NTRS)

    Wohlgemuth, J.; Wihl, M.; Rosenfield, T.

    1979-01-01

    Terrestrial panels were fabricated using rectangular cells. Packing densities in excess of 90% with panel conversion efficiencies greater than 13% were obtained. Higher density panels can be produced on a cost competitive basis with the standard salami panels.

  14. 77 FR 30044 - Occupational Information Development Advisory Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    .... SUPPLEMENTARY INFORMATION: Type of meeting: The teleconference meeting is open to the public. Purpose: The Occupational Information Development Advisory Panel (Panel) is a discretionary panel, established under the... ADMINISTRATION Occupational Information Development Advisory Panel Meeting AGENCY: Social Security...

  15. 76 FR 40768 - Occupational Information Development Advisory Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ADMINISTRATION Occupational Information Development Advisory Panel Meeting AGENCY: Social Security Administration... Development Advisory Panel (panel) is a discretionary panel, established under the Federal Advisory Committee... development and testing of a content model and taxonomy, work analysis instrumentation, sampling, and data...

  16. 76 FR 70804 - Occupational Information Development Advisory Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... ADMINISTRATION Occupational Information Development Advisory Panel Meeting AGENCY: Social Security Administration... Development Advisory Panel (panel) is a discretionary panel, established under the Federal Advisory Committee... development and testing of a content model and taxonomy, work analysis instrumentation, sampling, and data...

  17. Analytical comparison of three stiffened panel concepts

    NASA Technical Reports Server (NTRS)

    Maloney, Jill M.; Wu, K. Chauncey; Robinson, James C.

    1995-01-01

    Three stiffened panel concepts are evaluated to find optimized designs for integral stiffeners in the barrels of Reusable Launch Vehicle fuel tanks. The three panel concepts considered are a T-stiffened panel, a panel with one blade stiffener centered between each pair of T-stiffeners, and a panel with two blade stiffeners equally spaced between each pair of T-stiffeners. The panels are optimized using PASCO for a range of compressive loads, and the computed areal weight for each panel is used to compare the concepts and predict tank weights. The areal weight of the T-stiffened panel with one blade is up to seven-percent lower than the other panel concepts. Two tank construction methods are compared for a representative tank design with three barrels. In the first method, 45-degree circumferential sections of a barrel are each designed to carry the same maximum load in the barrel. In the second method, each barrel section is designed for the maximum load in that section. Representative tanks designed with the first method are over 250 lb heavier than tanks designed using the second method. Optimized panel designs and areal weights are also computed for variation of the nominal panel length and skin thickness.

  18. Highly stretchable, transparent ionic touch panel

    NASA Astrophysics Data System (ADS)

    Kim, Chong-Chan; Lee, Hyun-Hee; Oh, Kyu Hwan; Sun, Jeong-Yun

    2016-08-01

    Because human-computer interactions are increasingly important, touch panels may require stretchability and biocompatibility in order to allow integration with the human body. However, most touch panels have been developed based on stiff and brittle electrodes. We demonstrate an ionic touch panel based on a polyacrylamide hydrogel containing lithium chloride salts. The panel is soft and stretchable, so it can sustain a large deformation. The panel can freely transmit light information because the hydrogel is transparent, with 98% transmittance for visible light. A surface-capacitive touch system was adopted to sense a touched position. The panel can be operated under more than 1000% areal strain without sacrificing its functionalities. Epidermal touch panel use on skin was demonstrated by writing words, playing a piano, and playing games.

  19. Gallium arsenide - Solar panel assembly technology

    NASA Astrophysics Data System (ADS)

    Zemmrich, D.; Mardesich, N.; Macfarlane, B.; Loo, R.

    Gallium arsenide (GaAs) solar cell devices are maturing at 18 percent AM0 efficiencies for liquid phase epitaxy (LPE) technology, and efforts must be intensified placing necessary focus on the development of panel assembly techniques, and ultimately panel manufacturing methods capable of maintaining these high efficiencies for on-panel operation. Key problems and solutions are described which were experienced during the assembly of flight qualified solar panels using Spectrolab's mature (silicon) panel manufacturing processes for assembly of LPE GaAs solar cells. These cells were produced by Hughes Malibu (supplied by the U.S. Air Force WPAFB) ranging in efficiency from 15 to 17 percent, air mass zero (AM0) 28 C. Cell assembly methods for coverglass installation, submodule, and circuit soldering, as well as panel bonding are discussed. The LIPS II satellite, using a GaAs solar cell panel was successfully launched in 1983.

  20. Flat panel display Impurity doping technology for flat panel displays

    NASA Astrophysics Data System (ADS)

    Suzuki, Toshiharu

    2005-08-01

    Features of the flat panel displays (FPDs) such as liquid crystal display (LCD) and organic light emitting diode (OLED) display, etc. using low temperature poly-Si (LTPS) thin film transistors (TFTs) are briefly reviewed comparing with other FPDs. The requirements for fabricating TFTs used for high performance FPDs and system on glass (SoG) are addressed. This paper focuses on the impurity doping technology, which is one of the key technologies together with crystallization by laser annealing, formation of high quality gate insulator and gate-insulator/poly-Si interface. The issues to be solved in impurity doping technology for state of the art and future TFTs are clarified.

  1. A new and fast methodology to assess oxidative damage in cardiovascular diseases risk development through eVol-MEPS-UHPLC analysis of four urinary biomarkers.

    PubMed

    Mendes, Berta; Silva, Pedro; Mendonça, Isabel; Pereira, Jorge; Câmara, José S

    2013-11-15

    In this work, a new, fast and reliable methodology using a digitally controlled microextraction by packed sorbent (eVol(®)-MEPS) followed by ultra-high pressure liquid chromatography (UHPLC) analysis with photodiodes (PDA) detection, was developed to establish the urinary profile levels of four putative oxidative stress biomarkers (OSBs) in healthy subjects and patients evidencing cardiovascular diseases (CVDs). This data was used to verify the suitability of the selected OSBs (uric acid-UAc, malondialdehyde-MDA, 5-(hydroxymethyl)uracil-5-HMUra and 8-hydroxy-2'-deoxyguanosine-8-oxodG) as potential biomarkers of CVDs progression. Important parameters affecting the efficiency of the extraction process were optimized, particularly stationary phase selection, pH influence, sample volume, number of extraction cycles and washing and elution volumes. The experimental conditions that allowed the best extraction efficiency, expressed in terms of total area of the target analytes and data reproducibility, includes a 10 times dilution and pH adjustment of the urine samples to 6.0, followed by a gradient elution through the C8 adsorbent with 5 times 50 µL of 0.01% formic acid and 3×50 µL of 20% methanol in 0.01% formic acid. The chromatographic separation of the target analytes was performed with a HSS T3 column (100 mm × 2.1 mm, 1.7 µm in particle size) using 0.01% formic acid 20% methanol at 250 µL min(-1). The methodology was validated in terms of selectivity, linearity, instrumental limit of detection (LOD), method limit of quantification (LOQ), matrix effect, accuracy and precision (intra-and inter-day). Good results were obtained in terms of selectivity and linearity (r(2)>0.9906), as well as the LOD and LOQ, whose values were low, ranging from 0.00005 to 0.72 µg mL(-1) and 0.00023 to 2.31 µg mL(-1), respectively. The recovery results (91.1-123.0%), intra-day (1.0-8.3%), inter-day precision (4.6-6.3%) and the matrix effect (60.1-110.3%) of eVol(®)-MEPS

  2. Theoretical analysis of the binding of iron(III) protoporphyrin IX to 4-methoxyacetophenone thiosemicarbazone via DFT-D3, MEP, QTAIM, NCI, ELF, and LOL studies.

    PubMed

    Nkungli, Nyiang Kennet; Ghogomu, Julius Numbonui

    2017-07-01

    Thiosemicarbazones display diverse pharmacological properties, including antimalarial activities. Their pharmacological activities have been studied in depth, but little of this research has focused on their antimalarial mode of action. To elucidate this antimalarial mechanism, we investigated the nature of the interactions between iron(III) protoporphyrin IX (Fe(III)PPIX) and the thione-thiol tautomers of 4-methoxyacetophenone thiosemicarbazone (MAPTSC). Dispersion-corrected density functional theory (DFT-D3), the quantum theory of atoms in molecules (QTAIM), the noncovalent interaction (NCI) index, the electron localization function (ELF), the localized orbital locator (LOL), and thermodynamic calculations were employed in this work. Fe(III)PPIX-MAPTSC binding is expected to inhibit hemozoin formation, thereby preventing Fe(III)PPIX detoxification in plasmodia. Preliminary studies geared toward the identification of atomic binding sites in the thione-thiol tautomers of MAPTSC were carried out using molecular electrostatic potential (MEP) maps and conceptual DFT-based local reactivity indices. The thionic sulfur and the (2) N-azomethine nitrogen/thiol sulfur of, respectively, the thione and thiol tautomers of MAPTSC were identified as the most favorable nucleophilic sites for electrophilic attack. The negative values of the computed Fe(III)PPIX-MAPTSC binding energies, enthalpies, and Gibbs free energies are indicative of the existence and stability of Fe(III)PPIX-MAPTSC complexes. MAPTSC-Fe(III) coordinate bonds and strong hydrogen bonds (N-H···O) between the NH2 group in MAPTSC and the C=O group in one propionate side chain of Fe(III)PPIX are crucial to Fe(III)PPIX-MAPTSC binding. QTAIM, NCI, ELF, and LOL analyses revealed a subtle interplay of weak noncovalent interactions dominated by dispersive-like van der Waals interactions between Fe(III)PPIX and MAPTSC that stabilize the Fe(III)PPIX-MAPTSC complexes.

  3. Spectroscopic (FT-IR/FT-Raman) and computational (HF/DFT) investigation and HOMO/LUMO/MEP analysis on 2-amino-4-chlorophenol.

    PubMed

    Ramalingam, S; Periandy, S; Karabacak, M; Karthikeyan, N

    2013-03-01

    The spectra (FT-IR and FT-Raman) of the present compound; 2-amino-4-chlorophenol (2A4CP) were recorded in the range of 4000-100 cm(-1). All the computational calculations were made in the ground state using the HF and DFT (B3LYP and B3PW91) methods with 6-31++G(d,p) and 6-311++G(d,p) basis sets. From potential energy surface calculation, there are two conformers, Rot-1 and Rot-2 for this molecule. The computational results detected that Rot-1 form is the most stable conformer. Making use of the recorded data, the complete vibrational assignments were made and analysis of the observed fundamental bands of molecule is carried out. The complete assignments were performed on the basis of the total energy distribution (TED) of the vibrational modes, calculated with scaled quantum mechanics (SQMs) method and PQS program. The shifting of the frequencies in the vibrational pattern of the title molecule due to the substitutions; NH(2) and Cl were deeply investigated by the vibrational analysis. Moreover, (13)C NMR and (1)H NMR chemical shifts were calculated by using the gauge independent atomic orbital (GIAO) method with HF/B3LYP/B3PW91 methods with 6-311++G(d,p). A study on the electronic properties, such as HOMO and LUMO energies, were performed by time-dependent DFT (TD-DFT) approach. Besides frontier molecular orbitals (FMOs), molecular electrostatic potential (MEP) was performed. NLO properties and Mulliken charges of the 2A4CP were also calculated and interpreted. The thermodynamic properties (heat capacity, entropy, and enthalpy) of the title compound at different temperatures were calculated in gas phase.

  4. Spectroscopic (FT-IR/FT-Raman) and computational (HF/DFT) investigation and HOMO/LUMO/MEP analysis on 2-amino-4-chlorophenol

    NASA Astrophysics Data System (ADS)

    Ramalingam, S.; Periandy, S.; Karabacak, M.; Karthikeyan, N.

    2013-03-01

    The spectra (FT-IR and FT-Raman) of the present compound; 2-amino-4-chlorophenol (2A4CP) were recorded in the range of 4000-100 cm-1. All the computational calculations were made in the ground state using the HF and DFT (B3LYP and B3PW91) methods with 6-31++G(d,p) and 6-311++G(d,p) basis sets. From potential energy surface calculation, there are two conformers, Rot-1 and Rot-2 for this molecule. The computational results detected that Rot-1 form is the most stable conformer. Making use of the recorded data, the complete vibrational assignments were made and analysis of the observed fundamental bands of molecule is carried out. The complete assignments were performed on the basis of the total energy distribution (TED) of the vibrational modes, calculated with scaled quantum mechanics (SQMs) method and PQS program. The shifting of the frequencies in the vibrational pattern of the title molecule due to the substitutions; NH2 and Cl were deeply investigated by the vibrational analysis. Moreover, 13C NMR and 1H NMR chemical shifts were calculated by using the gauge independent atomic orbital (GIAO) method with HF/B3LYP/B3PW91 methods with 6-311++G(d,p). A study on the electronic properties, such as HOMO and LUMO energies, were performed by time-dependent DFT (TD-DFT) approach. Besides frontier molecular orbitals (FMOs), molecular electrostatic potential (MEP) was performed. NLO properties and Mulliken charges of the 2A4CP were also calculated and interpreted. The thermodynamic properties (heat capacity, entropy, and enthalpy) of the title compound at different temperatures were calculated in gas phase.

  5. Space Launch System Panel Discussion

    NASA Image and Video Library

    2013-11-12

    L-R: William Gerstenmaier, NASA Associate Administrator for human exploration and operations; Charlie Precourt, Vice President and General Manager, ATK Space Launch Division; John Elbon, Vice President and General Manager, Boeing Space Exploration; Julie Van Kleek, Vice President, space programs, Aerojet Rocketdyne; and Jim Crocker, Vice President and General Manager, civil space, Lockheed Martin Space Systems, participate in a panel discussion on deep space exploration using the Space Launch System and Orion spacecraft at the Newseum in Washington on Tuesday, November 12, 2013. Photo Credit: (NASA/Jay Westcott)

  6. Report on Multiphase Flow Panel

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This paper presents viewgraphs on a multiphase flow panel. The topics include: 1) Discussion of Priorities; 2) Critical Issues Reduced Gravity Instabilities; 3) Severely Limiting Phase Separation; 4) Severely-Limiting Phase Change; 5) Enhancements; 6) Awareness Instabilities; 7) Awareness; 8) Methods of Resolution; 9) 2008 Space Flight; 10) 2003-2008 Ground-Based Microgravity Facilities; 11) 2003-2008 Other; 12) 2009-2015 Space Flight; 13) 2009-2015 Ground-Based Microgravity Facilities; 14) 2009-2015 Other; and 15) 2016.

  7. Theoretical design of lightning panel

    NASA Astrophysics Data System (ADS)

    Emetere, M. E.; Olawole, O. F.; Sanni, S. E.

    2016-02-01

    The light trapping device (LTD) was theoretically designed to suggests the best way of harvesting the energy derived from natural lightning. The Maxwell's equation was expanded using a virtual experimentation via a MATLAB environment. Several parameters like lightning flash and temperature distribution were consider to investigate the ability of the theoretical lightning panel to convert electricity efficiently. The results of the lighting strike angle on the surface of the LTD shows the maximum power expected per time. The results of the microscopic thermal distribution shows that if the LTD casing controls the transmission of the heat energy, then the thermal energy storage (TES) can be introduced to the lightning farm.

  8. Insulating panels with rice husk

    SciTech Connect

    Salas, J.; Veras, J.

    1986-01-01

    This study includes the quantitative results of tests caried out on 7.5 x 15.0 cm cylindrical test pieces and fullsized panels with a cement and rice husk, produced by using means belonging to the so-called ''appropriate technologies''. These results are summarized and analyzed with a view to providing a possible alternative for substituting other insulating materials, which are generally imported, in developing countries. The technical results presented point towards a promising future for the task undertaken, within the context of a research project on ''materials, technologies and prototypes for very low-cost housing'' which, in a - multinational capacity, is being developed at the Instituto E. Torroja.

  9. Automated solar panel assembly line

    NASA Technical Reports Server (NTRS)

    Somberg, H.

    1981-01-01

    The initial stage of the automated solar panel assembly line program was devoted to concept development and proof of approach through simple experimental verification. In this phase, laboratory bench models were built to demonstrate and verify concepts. Following this phase was machine design and integration of the various machine elements. The third phase was machine assembly and debugging. In this phase, the various elements were operated as a unit and modifications were made as required. The final stage of development was the demonstration of the equipment in a pilot production operation.

  10. Fruit Crop Pests. MEP 312.

    ERIC Educational Resources Information Center

    Weaver, Leslie O.; And Others

    As part of a cooperative extension service series by the University of Maryland this publication introduces the identification and control of common agricultural pests of fruit crops. The first of the five sections defines "pest" and "weed" and generally introduces different kinds of pests in the categories of insects, weeds,…

  11. Vegetable Crop Pests. MEP 311.

    ERIC Educational Resources Information Center

    Kantzes, James G.; And Others

    As part of a cooperative extension service series by the University of Maryland, this publication introduces the identification and control of common agricultural pests of vegetable crops. The first of the five sections defines "pest" and "weed" and generally introduces different kinds of pests in the categories of insects,…

  12. Vegetable Crop Pests. MEP 311.

    ERIC Educational Resources Information Center

    Kantzes, James G.; And Others

    As part of a cooperative extension service series by the University of Maryland, this publication introduces the identification and control of common agricultural pests of vegetable crops. The first of the five sections defines "pest" and "weed" and generally introduces different kinds of pests in the categories of insects,…

  13. Fruit Crop Pests. MEP 312.

    ERIC Educational Resources Information Center

    Weaver, Leslie O.; And Others

    As part of a cooperative extension service series by the University of Maryland this publication introduces the identification and control of common agricultural pests of fruit crops. The first of the five sections defines "pest" and "weed" and generally introduces different kinds of pests in the categories of insects, weeds,…

  14. Active magnetic compensation composed of shielding panels.

    PubMed

    Kato, K; Yamazaki, K; Sato, T; Haga, A; Okitsu, T; Muramatsu, K; Ueda, T; Kobayashi, K; Yoshizawa, M

    2004-11-30

    Magnetically shielded rooms (MSRs) with materials of high permeability and active shield systems have been used to shield magnetic noise for biomagnetic measurements up to now. However, these techniques have various disadvantages. Therefore, we have developed a new shielding system composed of shielding panels using an active compensation technique. In this study, we evaluated the shielding performance of several unit panels attached together. Numerical and experimental approaches indicated that the shielding factor of a cubic model composed of 24 panels was 17 for uniform fields, and 7 for disturbances due to car movement. Furthermore, the compensation space is larger than that of an ordinary active system using large coils rather than panels. Moreover, the new active compensation system has the important advantage that panels of any shape can be assembled for occasional use because the unit panels are small and light.

  15. Castro Valley High School's Solar Panels

    NASA Astrophysics Data System (ADS)

    Lew, A.; Ham, S.; Shin, Y.; Yang, W.; Lam, J.

    2014-12-01

    Solar panels are photovoltaic cells that are designed to convert the sun's kinetic energy to generate usable energy in the form of electricity. Castro Valley High School has tried to offset the cost of electricity by installing solar panels, costing the district approximately 3.29 million dollars, but have been installed incorrectly and are not operating at peak efficency. By using trigonometry we deduced that Castro Valley High School's south facing solar panels were at an incline of 10o and that the east and west facing solar panels are at an incline of 5o. By taking the averages of the optimum angles for the months of September through May, roughly when school is in session, we found that the optimum angle for south facing solar panels should be roughly 46o. This shows that Castro Valley High School has not used it's budget to its full potential due to the fact that the solar panels were haphazardly installed.

  16. Solar-Panel Dust Accumulation and Cleanings

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Air-fall dust accumulates on the solar panels of NASA's Mars Exploration Rovers, reducing the amount of sunlight reaching the solar arrays. Pre-launch models predicted steady dust accumulation. However, the rovers have been blessed with occasional wind events that clear significant amounts of dust from the solar panels.

    This graph shows the effects of those panel-cleaning events on the amount of electricity generated by Spirit's solar panels. The horizontal scale is the number of Martian days (sols) after Spirit's Jan. 4, 2005, (Universal Time) landing on Mars. The vertical scale indicates output from the rover's solar panels as a fraction of the amount produced when the clean panels first opened. Note that the gradual declines are interrupted by occasional sharp increases, such as a dust-cleaning event on sol 420.

  17. Buckling of cylindrical panels under axial compression

    NASA Technical Reports Server (NTRS)

    Sobel, L. H.; Weller, T.; Agarwal, B. L.

    1976-01-01

    This paper investigates the effects of boundary conditions and panel width on the axially compressive buckling behavior of unstiffened, isotropic, circular cylindrical panels. Numerical results are presented for eight different sets of boundary conditions along the straight edges of the panels. For all sets of boundary conditions except one (SS1), the results show that the panel buckling loads monotonically approach the complete cylinder buckling load from above as the panel width is increased. Low buckling loads, sometimes less than half the complete cylinder buckling load, are found for simply supported panels with free in-plane edge displacements (SS1). It is observed that the prevention of circumferential edge displacement is the most important in-plane boundary condition from the point of view of increasing the buckling load; and that the prevention of edge rotation in the circumferential direction also significantly increases the buckling load.

  18. Solar-Panel Dust Accumulation and Cleanings

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Air-fall dust accumulates on the solar panels of NASA's Mars Exploration Rovers, reducing the amount of sunlight reaching the solar arrays. Pre-launch models predicted steady dust accumulation. However, the rovers have been blessed with occasional wind events that clear significant amounts of dust from the solar panels.

    This graph shows the effects of those panel-cleaning events on the amount of electricity generated by Spirit's solar panels. The horizontal scale is the number of Martian days (sols) after Spirit's Jan. 4, 2005, (Universal Time) landing on Mars. The vertical scale indicates output from the rover's solar panels as a fraction of the amount produced when the clean panels first opened. Note that the gradual declines are interrupted by occasional sharp increases, such as a dust-cleaning event on sol 420.

  19. Sound transmission loss of composite sandwich panels

    NASA Astrophysics Data System (ADS)

    Zhou, Ran

    Light composite sandwich panels are increasingly used in automobiles, ships and aircraft, because of the advantages they offer of high strength-to-weight ratios. However, the acoustical properties of these light and stiff structures can be less desirable than those of equivalent metal panels. These undesirable properties can lead to high interior noise levels. A number of researchers have studied the acoustical properties of honeycomb and foam sandwich panels. Not much work, however, has been carried out on foam-filled honeycomb sandwich panels. In this dissertation, governing equations for the forced vibration of asymmetric sandwich panels are developed. An analytical expression for modal densities of symmetric sandwich panels is derived from a sixth-order governing equation. A boundary element analysis model for the sound transmission loss of symmetric sandwich panels is proposed. Measurements of the modal density, total loss factor, radiation loss factor, and sound transmission loss of foam-filled honeycomb sandwich panels with different configurations and thicknesses are presented. Comparisons between the predicted sound transmission loss values obtained from wave impedance analysis, statistical energy analysis, boundary element analysis, and experimental values are presented. The wave impedance analysis model provides accurate predictions of sound transmission loss for the thin foam-filled honeycomb sandwich panels at frequencies above their first resonance frequencies. The predictions from the statistical energy analysis model are in better agreement with the experimental transmission loss values of the sandwich panels when the measured radiation loss factor values near coincidence are used instead of the theoretical values for single-layer panels. The proposed boundary element analysis model provides more accurate predictions of sound transmission loss for the thick foam-filled honeycomb sandwich panels than either the wave impedance analysis model or the

  20. Multi-clad black display panel

    DOEpatents

    Veligdan, James T.; Biscardi, Cyrus; Brewster, Calvin

    2002-01-01

    A multi-clad black display panel, and a method of making a multi-clad black display panel, are disclosed, wherein a plurality of waveguides, each of which includes a light-transmissive core placed between an opposing pair of transparent cladding layers and a black layer disposed between transparent cladding layers, are stacked together and sawed at an angle to produce a wedge-shaped optical panel having an inlet face and an outlet face.