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Sample records for parc electronucleaire francais

  1. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs…

  2. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  3. The Language Laboratory of the Ecole de Francais Moderne of the University of Lausanne

    ERIC Educational Resources Information Center

    Guex, Andre

    1974-01-01

    This is a description of the materials developed for the language laboratory of the Ecole de Francais Moderne at the University of Lausanne. The tapes are designed to deal specifically with French phonetics, grammar, and lexicon. (AM)

  4. Design concept for the microwave interrogation structure in PARCS

    NASA Technical Reports Server (NTRS)

    Dick, G. J.; Klipstein, W. M.; Heavner, T. P.; Jefferts, S. R.

    2002-01-01

    In this paper we will describe key aspects of the conceptual design of the microwave interrogation structure in the laser-cooled cesium frequency standard that is part of the Primary Atomic Reference Clock in Space (PARCS) experiment.

  5. Features Of The J-PARC Linac

    SciTech Connect

    Kobayashi, Tetsuya

    2011-06-01

    Japan Proton Accelerator Research Complex (J-PARC) will be one of the highest intensity proton accelerators in the world aiming to realize 1 MW class of the beam power. The accelerator consists of a 400-MeV linac, a 3-GeV rapid-cycling synchrotron (RCS) and a main ring synchrotron (MR), and the accelerated beam is applied to several experimental facilities. The linac, which is the injector for the RCS, has about 50 cavity modules to accelerate the beam up to 400 MeV. The acceleration field error in all of them should be within {+-}1% in amplitude and {+-}1 degree in phase because the momentum spread of the RCS injection beam is required to be within 0.1%. For the cavity field stabilization, a high-stable optical signal distribution system is used as the RF reference, and sophisticated digital feedback and feed-forward system is working well in the low level RF control system. Consequently the providing beam to the RCS is very stable, and the beam commissioning and the experiments of the application facilities have been progressed steadily.

  6. The Lycee Francais in New York: A Showcase for the French-Speaking Community

    ERIC Educational Resources Information Center

    Michel, Florence

    2004-01-01

    In New York they say that the architecture of the new "Lycee francais" (serving French students from kindergarten through upper secondary education) was inspired by the rationalism of Descartes. What is beyond doubt, however, is that the design and materials chosen by the American firm of architects, "Polshek Partnership…

  7. Le "Francais Populaire" and French as a Second Language: A Comparative Study of Language Simplification.

    ERIC Educational Resources Information Center

    Kenemer, Virginia Lynn

    The French of English speaking students of French as a second language is compared with "francais populaire" (FP) in order to determine similarities in their tendency toward simplified grammar and morphology. Simplifying characteristics that are typical of FP were obtained from French working class sources, while simplification patterns…

  8. La culture politique du Mouvement Quebec Francais [The Political Culture of the "French Quebec Movement"].

    ERIC Educational Resources Information Center

    Turcotte, Denis

    This study of the "Mouvement Quebec Francais (MQF)" covers the period from March 1971 through Spring 1974. The fundamental postulate of the study is that if the political culture is internalized by individuals, it is at the same time borne by groups. The study of groups represents, therefore, a good vehicle to reveal the most significant…

  9. Muonium in J-PARC; from fundamental to application

    NASA Astrophysics Data System (ADS)

    Shimomura, K.

    2015-08-01

    At J-PARC, the muon science facility (MUSE) was successfully constructed in the Materials and Life Science Facility (MLF), and three scientific activities is now ongoing related muonium (Mu) from fundamental to application; 1) Mu hyperfine structure measurement (MuSEUM), 2) Ultra Slow Muon Microscope (USMM) and 3) muon g-2 and EDM measurement. Here, we will report present status of each activity.

  10. High-energy hadron physics at J-PARC

    SciTech Connect

    Kumano, S.

    2008-10-13

    The J-PARC facility is near completion and experiments will start in 2009 on nuclear and particle physics projects. In this article, the J-PARC facility is introduced, and possible projects are discussed in high-energy hadron physics by using the primary proton beam of 30-50 GeV. There are proposed experiments on charm-production and Drell-Yan processes as well as single spin asymmetries for investigating quark and gluon structure of the nucleon and nuclei. Parton-energy loss could be studied in the Drell-Yan processes. There is also a proposal on hadron-mass modifications in a nuclear medium by using the proton beam. In addition, possible topics include transition from hadron to quark degrees of freedom by elastic pp scattering, color transparency by (p,2p), short-range correlation in nuclear force by (p,2pN), tensor structure functions for spin-one hadrons, fragmentation functions, and generalized partem distributions in the ERBL region although proposals are not written on these projects. If proton-beam polarization is attained, it is possible to investigate details of nucleon spin structure. In the last part of this article, our own studies are explained on partem distribution functions in connection with the J-PARC projects.

  11. Annual Report: 2014: Partners in Amphibian and Reptile Conservation (PARC)

    USGS Publications Warehouse

    Weir, Linda A.; Nanjappa, P.; Apodaca, J. J.; Williams, J.

    2015-01-01

    Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effects from overexploitation; these animals are also burdened by humans attitudes – that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural and cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation to ensure healthy populations of these animals has never been more important. As you will see herein, PARC’s 15th anniversary has been marked with major accomplishments and an ever-increasing momentum. With your help, PARC can continue to build on its successes and protect these vital species.

  12. A Study of Polarized Proton Acceleration in J-PARC

    SciTech Connect

    Luccio, A. U.; Bai, M.; Roser, T.; Molodojentsev, A.; Ohmori, C.; Sato, H.; Hatanaka, K.

    2007-06-13

    We have studied the feasibility of polarized proton acceleration in rhe J-PARC accelerator facility, consisting of a 400 MeV linac, a 3 GeV rapid cycling synchrotron (RCS) and a 50 GeV synchrotron (MR). We show how the polarization of the beam can be preserved using an rf dipole in the RCS and two superconductve partial helical Siberian snakes in the MR. The lattice of the MR will be modified with the addition of quadrupoles to compensate for the focusing properties of the snakes.

  13. A STUDY OF POLARIZED PROTON ACCELERATION IN J-PARC.

    SciTech Connect

    LUCCIO, A.U.; BAI, M.; ROSER, T.

    2006-10-02

    We have studied the feasibility of polarized proton acceleration in rhe J-PARC accelerator facility, consisting of a 400 MeV linac, a 3 GeV rapid cycling synchrotron (RCS) and a 50 GeV synchrotron (MR). We show how the polarization of the beam can be preserved using an rf dipole in the RCS and two superconductive partial helical Siberian snakes in the MR. The lattice of the MR will be modified with the addition of quadrupoles to compensate for the focusing properties of the snakes.

  14. Performance of the PARCS Testbed Cesium Fountain Frequency Standard

    NASA Technical Reports Server (NTRS)

    Enzer, Daphna G.; Klipstein, William M.

    2004-01-01

    A cesium fountain frequency standard has been developed as a ground testbed for the PARCS (Primary Atomic Reference Clock in Space) experiment, an experiment intended to fly on the International Space Station. We report on the performance of the fountain and describe some of the implementations motivated in large part by flight considerations, but of relevance for ground fountains. In particular, we report on a new technique for delivering cooling and trapping laser beams to the atom collection region, in which a given beam is recirculated three times effectively providing much more optical power than traditional configurations. Allan deviations down to 10 have been achieved with this method.

  15. TRACE/PARCS modelling of rips trip transients for Lungmen ABWR

    SciTech Connect

    Chang, C. Y.; Lin, H. T.; Wang, J. R.; Shih, C.

    2012-07-01

    The objectives of this study are to examine the performances of the steady-state results calculated by the Lungmen TRACE/PARCS model compared to SIMULATE-3 code, as well as to use the analytical results of the final safety analysis report (FSAR) to benchmark the Lungmen TRACE/PARCS model. In this study, three power generation methods in TRACE were utilized to analyze the three reactor internal pumps (RIPs) trip transient for the purpose of validating the TRACE/PARCS model. In general, the comparisons show that the transient responses of key system parameters agree well with the FSAR results, including core power, core inlet flow, reactivity, etc. Further studies will be performed in the future using Lungmen TRACE/PARCS model. After the commercial operation of Lungmen nuclear power plant, TRACE/PARCS model will be verified. (authors)

  16. Proposal to Participate in J-Parc KL Experiment

    SciTech Connect

    Campbell, Myron; Tecchio, Monica

    2013-02-03

    During the previous grant period we have been working on the J-PARC KL E14 (KOTO) experiment with the goal to discover and measure the rate of the rare decay neutral kaons to a pion and two neutrinos. This CP-violating flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement to the branching ratio, which in the Standard Model predicted to be about 2.80E-11. The experiment is expected to observe 100 events at the Standard Model branching ratio for a 10% measurement. The experiment is a follow-up to E391a at KEK and has been approved as experiment E14 at J-PARC. The main barrel vacuum vessel, the charged veto detectors, and the main barrel photon veto system will be reused from E391a. The main calorimeter has been replaced with Cesium Iodide crystals that are both smaller to provide improved shower reconstruction and longer to prevent energy leakage out of the back of the calorimeter. New trigger and data acquisitions electronics will be used.

  17. Precision spectroscopy of kaonic {sup 3}He X-rays at J-PARC

    SciTech Connect

    Sato, M.; Fujiwara, Y.; Hashimoto, T.; Hayano, R. S.; Ishikawa, T.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Wuenschek, B.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.; Vidal, A. Romero

    2011-10-24

    We will measure the X-rays from kaonic {sup 3}He 3d {yields} 2p transition with a precision below 2 eV. It can provide crucial information on the kaon-nucleus strong interaction. The experiment (J-PARC E17) will be performed as Day-1, which is one of the first experiments in the J-PARC hadron facility in the year 2011. An overview and the present status of the J-PARC E17 experiment are described.

  18. New muonium HFS measurements at J-PARC/MUSE

    NASA Astrophysics Data System (ADS)

    Strasser, P.; Aoki, M.; Fukao, Y.; Higashi, Y.; Higuchi, T.; Iinuma, H.; Ikedo, Y.; Ishida, K.; Ito, T. U.; Iwasaki, M.; Kadono, R.; Kamigaito, O.; Kanda, S.; Kawall, D.; Kawamura, N.; Koda, A.; Kojima, K. M.; Kubo, K.; Matsuda, Y.; Matsudate, Y.; Mibe, T.; Miyake, Y.; Mizutani, T.; Nagamine, K.; Nishimura, S.; Nishiyama, K.; Ogitsu, T.; Okubo, R.; Saito, N.; Sasaki, K.; Seo, S.; Shimomura, K.; Sugano, M.; Tajima, M.; Tanaka, K. S.; Tanaka, T.; Tomono, D.; Torii, H. A.; Torikai, E.; Toyoda, A.; Ueno, K.; Ueno, Y.; Yagi, D.; Yamamoto, A.; Yoshida, M.

    2016-12-01

    At the Muon Science Facility (MUSE) of J-PARC (Japan Proton Accelerator Research Complex), the MuSEUM collaboration is planing new measurements of the ground state hyperfine structure (HFS) of muonium both at zero field and at high magnetic field. The previous measurements were performed both at LAMPF (Los Alamos Meson Physics Facility) with experimental uncertainties mostly dominated by statistical errors. The new high intensity muon beam that will soon be available at MUSE H-Line will provide an opportunity to improve the precision of these measurements by one order of magnitude. An overview of the different aspects of these new muonium HFS measurements, the current status of the preparation, and the results of a first commissioning test experiment at zero field are presented.

  19. Calculation of Accurate Hexagonal Discontinuity Factors for PARCS

    SciTech Connect

    Pounders. J., Bandini, B. R. , Xu, Y, and Downar, T. J.

    2007-11-01

    In this study we derive a methodology for calculating discontinuity factors consistent with the Triangle-based Polynomial Expansion Nodal (TPEN) method implemented in PARCS for hexagonal reactor geometries. The accuracy of coarse-mesh nodal methods is greatly enhanced by permitting flux discontinuities at node boundaries, but the practice of calculating discontinuity factors from infinite-medium (zero-current) single bundle calculations may not be sufficiently accurate for more challenging problems in which there is a large amount of internodal neutron streaming. The authors therefore derive a TPEN-based method for calculating discontinuity factors that are exact with respect to generalized equivalence theory. The method is validated by reproducing the reference solution for a small hexagonal core.

  20. Physics in J-PARC Hadron-Hall Extension

    NASA Astrophysics Data System (ADS)

    Noumi, Hiroyuki

    The Hadron Experimental Facility (HEF) of the Japan Proton Accelerator Research Complex (J-PARC) provides the world highest intensity hadron beams, such as kaons, pions, and so on, for various experimental researches in particle and nuclear physics. Currently, HEF operates two charged and one neutral secondary beam lines, K1.8, K1.1, and KL, sharing secondary beams produced at a primary target, T1. In addition, a high-momentum beam line is being constructed, which is branched from the primary beam line to deliver a fraction of the primary proton beam. We have a plan to extend HEF and construct a several new beam lines, which would enhance physics opportunities at HEF. A floor plan of extended HEF and physics scopes are presented.

  1. Beam position monitor system of J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Hayashi, N.; Kawase, M.; Hatakeyama, S.; Hiroki, S.; Saeki, R.; Takahashi, H.; Teruyama, Y.; Toyokawa, R.; Arakawa, D.; Hiramatsu, S.; Lee, S.; Satou, K.; Tejima, M.; Toyama, T.

    2012-06-01

    The J-PARC RCS is a 25 Hz Rapid-Cycling proton Synchrotron and its designed beam power is 1 MW. The beam position monitor (BPM) system at J-PARC RCS is described in this paper. The pre-defined diameter of the BPM detectors is larger than 250 mm, however, the system has to measure the beam position very accurately. In addition, it is necessary to have a large dynamic range. The system should work not only for the high intensity but also for low intensity, such as during beam commissioning, when the intensity is below 1% of the design intensity. There are 54 BPM detectors around the ring and most of them are placed inside steering magnets because of quite limited space. The BPM detector is an electro-static type and it has four electrodes, and a pair of electrodes gives a good linear response with a diagonal cut shape to detect the charge center precisely. The signal processing units, which are equipped with 14-bit 40 MS/s ADC and 600 MHz DSP, have been developed. They are accessed via shared memory space and controlled by EPICS. Such a processing unit is capable of recording the full 25 Hz pulse data for the so-called "COD mode" (averaged beam position calculation) and it can also store the whole waveform data for further analysis, like turn-by-turn position calculation. The resolution was estimated to be 20 μm for "COD mode" and to be 0.3 mm for the turn-by-turn mode with relatively low intensity of 8×1011 ppp. The position accuracy is estimated to be about 0.5 mm using a newly developed Beam Based Alignment (BBA) method.

  2. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1991-1993.

    ERIC Educational Resources Information Center

    Haillet, P., Ed.; And Others

    1993-01-01

    This document consists of the first two issues of the journal RELIEF. Each issue contains four articles. All articles deal with French second language instruction: (1) "Utiliser la presse ecrite en classe de francais-langue seconde (Using the Print Media in French Second Language Class)" (H. Canto); (2) "Une lecon de grammaire…

  3. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1994.

    ERIC Educational Resources Information Center

    Mahler, M., Ed.; Haillet, P., Ed.

    1994-01-01

    Contains five articles, all in French, reporting research on French second language instruction. "Francophonie et francais langue seconde a l'oral: quel(s) culture(s), quelles methodes?" (Francophony and Spoken French as a Second Language: What Cultures(s), What Method(s) (D. Issa-Sayegh) discusses the content and structure of a…

  4. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide

    SciTech Connect

    Vitali, Roberta; Cesi, Vincenzo; Tanno, Barbara; Ferrari-Amorotti, Giovanna; Dominici, Carlo; Calabretta, Bruno; Raschella, Giuseppe

    2008-04-04

    We tested the activity of a p53 carboxy-terminal peptide containing the PARC-interacting region in cancer cells with wild type cytoplasmic p53. Peptide delivery was achieved by fusing it to the TAT transduction domain (TAT-p53-C-ter peptide). In a two-hybrid assay, the tetramerization domain (TD) of p53 was necessary and sufficient to bind PARC. The TAT-p53-C-ter peptide disrupted the PARC-p53 complex. Peptide treatment caused p53 nuclear relocation, p53-dependent changes in gene expression and enhancement of etoposide-induced apoptosis. These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.

  5. Current status of the J-PARC muon facility, MUSE

    NASA Astrophysics Data System (ADS)

    Miyake, Y.; Shimomura, K.; Kawamura, N.; Strasser, P.; Koda, A.; Fujimori, H.; Ikedo, Y.; Makimura, S.; Kobayashi, Y.; Nakamura, J.; Kojima, K.; Adachi, T.; Kadono, R.; Takeshita, S.; Nishiyama, K.; Higemoto, W.; Ito, T.; Nagamine, K.; Ohata, H.; Makida, Y.; Yoshida, M.; Okamura, T.; Okada, R.; Ogitsu, T.

    2014-12-01

    The muon science facility (MUSE), along with the neutron, hadron, and neutrino facilities, is one of the experimental areas of the J-PARC project. The MUSE facility is located in the Materials and Life Science Facility (MLF), which is a building integrated to include both neutron and muon science programs. Since the autumn of 2008, users operation is effective and making use of the pulsed muon beam particularly at the D-Line. Unfortunately, MUSE suffered severe damages from the earthquake on March 11, 2011, the so-called "Higashi-Nippon Dai-Shinsai". We managed to have a stable operation of the superconducting solenoid magnet with use of the on-line refrigerator on December, 2012, although we had to overcome a lot of difficulties against components not working properly. But we had to stop again the whole operations on May 2013, because of the radioactive materials leakage accident at the Hadron Hall Experimental Facility. Finally we restarted the users' runs on February 2014.

  6. The TREK/E36 experiment at J-PARC

    SciTech Connect

    Kohl, M.; Collaboration: TREK Collaboration

    2013-11-07

    Experiment E36 is planned to run at the J-PARC K1.1BR kaon beamline in 2014-15 using a stopped kaon beam along with the TREK target and detector setup. The decay products of stopped positive kaons will be observed with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the K{sub e2}/K{sub μ2} ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for a heavy sterile neutrino in two-body kaon decay, along with additional searches for exotic decay modes including the possibility to produce a dark photon and to observe its decay into an e{sup +}e{sup −} pair. An overview of the planned measurements with E36 will be presented.

  7. Status of the KOTO experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Beckford, Brian

    2017-01-01

    The K0TO experiment conducted at J-PARC was designed to observe the KL0-->π0 ν ν decay and measure its branching ratio. The current SM prediction for the branching ratio is 3.0 x 10-11 with a small theoretical uncertainty of about 2-3 As a result of the favorable outcome of KEK E391, the K0TO experiment is intended to pursue the search with increased beam power, an upgraded data acquisition system, and improved detector hardware. The signature of the decay is a pair of photons from the π0 decay and no other detected particles. For the measurement of the energies and positions of the photons, K0TO uses a Cesium Iodide (CSI) electromagnetic calorimeter as the main detector, and hermetic veto counters to guarantee that there are no other detected particles. The initial data was collected in 2013, followed by additional runs in 2015-2016 at beam powers of 24 and 40 kW, respectively. In this talk, we present a description of the upgrades and improvements to the detector, present status, and the latest results. For the K0TO collaboration.

  8. A Design for Living: The PARC Plan. Report of the PARC Ad Hoc Planning Committee for Resolution II, October 19, 1974.

    ERIC Educational Resources Information Center

    Pennsylvania Association for Retarded Citizens, Harrisburg.

    Presented is the PARC (Pennsylvania Association for Retarded Citizens) Plan which resulted from a 3-month survey of Pennsylvania's institutional system and which was designed to improve living conditions and programs of state schools and hospitals serving the mentally retarded. Detailed are specific recommendations for the achievement of annual…

  9. Cryogenic system for COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Ki, Taekyung; Yoshida, Makoto; Yang, Ye; Ogitsu, Toru; Iio, Masami; Makida, Yasuhiro; Okamura, Takahiro; Mihara, Satoshi; Nakamoto, Tatsushi; Sugano, Michinaka; Sasaki, Ken-ichi

    2016-07-01

    Superconducting conductors and cryogenic refrigeration are key factors in the accelerator science because they enable the production of magnets needed to control and detect the particles under study. In Japan, a system for COMET (Coherent Muon to Electron Transition), which will produce muon beam lines, is under the construction at J-PARC (Japan Proton Accelerator Research Complex). The system consists of three superconducting magnets; the first is a pion-capture solenoid, the second is a muon-transport solenoid, and the third is a detector solenoid. It is necessary to cool down the magnets efficiently using two-phase helium and maintain them securely at 4.5 K. For stable cryogenic refrigeration of the magnets, a suitable cooling method, structures, and the irradiation effect on materials should be investigated. In this paper, we focus on the development of an overall cryogenic system for cooling the capture and transport solenoids. A conduction-cooling method is considered for cooling the capture and transport solenoids because of the advantages such as the reduction of total heat load, fewer components, and simplified structure. To supply cryogenic fluids (4.5 K liquid helium and 58 K gas helium) and currents to the conduction-cooled magnets subjected to high irradiation, cryogenic components (cooling paths in the magnets, transfer tubes, and a current lead box) are developed. Based on the environment of high irradiation, the conditions (temperature and pressure) of helium in cooling paths are estimated, as well as the temperature of the capture magnet. We develop a dynamic model for quench simulation and estimate the maximum pressure in the cooling pipe when the capture magnet quenches. We conclude with a discussion of the next steps and estimated challenges for the cryogenic system.

  10. Science Goals of the Primary Atomic Reference Clock in Space (PARCS) Experiment

    NASA Technical Reports Server (NTRS)

    Ashby, N.

    2003-01-01

    The PARCS (Primary Atomic Reference Clock in Space) experiment will use a laser-cooled Cesium atomic clock operating in the microgravity environment aboard the International Space Station (ISS) to provide both advanced tests of gravitational theory and to demonstrate a new cold-atom clock technology for space. PARCS is a joint project of the National Institute of Standards and Technology (NIST), NASA's Jet Propulsion Laboratory (JPL), and the University of Colorado (CU). This paper concentrates on the scientific goals of the PARCS mission. The microgravity space environment allows laser-cooled Cs atoms to have Ramsey times in excess of those feasible on Earth, resulting in improved clock performance. Clock stabilities of 5x10(exp -14) at one second, and accuracies better than 10(exp -16) are projected.

  11. The Time Reversal Experiment with Kaons (TREK) at J-PARC

    SciTech Connect

    Kohl, Michael

    2009-08-04

    The Time Reversal Experiment with Kaons (TREK) at J-PARC aims to find CP violation beyond the Standard Model in the semi-leptonic K{sub {mu}}{sub 3}{sup +} decay mode by measuring the T-violating transverse polarization P{sub T} of outgoing muons. TREK makes use of the intense kaon beam at J-PARC stopped in a target and employs an optimized setup with excellent control of systematic uncertainties. The sensitivity at J-PARC is improved by a factor of 20 compared to the current uncertainty for P{sub T}, well in the predicted range of various New Physics models. An overview of the planned experiment and current status will be presented.

  12. PARC Navier-Stokes code upgrade and validation for high speed aeroheating predictions

    NASA Technical Reports Server (NTRS)

    Liver, Peter A.; Praharaj, Sarat C.; Seaford, C. Mark

    1990-01-01

    Applications of the PARC full Navier-Stokes code for hypersonic flowfield and aeroheating predictions around blunt bodies such as the Aeroassist Flight Experiment (AFE) and Aeroassisted Orbital Transfer Vehicle (AOTV) are evaluated. Two-dimensional/axisymmetric and three-dimensional perfect gas versions of the code were upgraded and tested against benchmark wind tunnel cases of hemisphere-cylinder, three-dimensional AFE forebody, and axisymmetric AFE and AOTV aerobrake/wake flowfields. PARC calculations are in good agreement with experimental data and results of similar computer codes. Difficulties encountered in flowfield and heat transfer predictions due to effects of grid density, boundary conditions such as singular stagnation line axis and artificial dissipation terms are presented together with subsequent improvements made to the code. The experience gained with the perfect gas code is being currently utilized in applications of an equilibrium air real gas PARC version developed at REMTECH.

  13. Searching for Sterile Neutrinos at J-PARC with JSNS2

    NASA Astrophysics Data System (ADS)

    Jordan, Johnathon; JSNS2 Collaboration

    2017-01-01

    The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) will look for neutrino oscillations with a characteristic frequency of Δm2 1 eV2. The experiment will be constructed at the J-PARC Material and Life Science Experimental Facility (MLF) and will perform a search for νμ ->νe oscillations over a 24 m baseline using muon decay at rest neutrinos originating from 3 GeV proton interactions with a mercury target. Using two tanks of Gd-doped liquid scintillator with a total fiducial volume of 50 tons, JSNS2 will exploit the unique signature of inverse beta decay (prompt positron signal, delayed gammas from neutron capture) to look for νe appearance. Additionally, JSNS2 will enable novel cross section measurements using 236 MeV muon neutrinos from charged kaon decay at rest (KDAR).

  14. Precision Spectroscopy of Kaonic Helium-3 X-rays at J-PARC

    SciTech Connect

    Hashimoto, T.; Fujiwara, Y.; Hayano, R. S.; Ishikawa, T.; Sato, M.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Widmann, E.; Wuenschek, B. K.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.

    2011-10-21

    We will measure the x-rays from kaonic {sup 3}He and {sup 4}He 3d{yields}2p transition by using silicon drift detectors. Our precision goal is set to 1 eV to provide crucial information on the kaon-nucleus strong interaction in the low energy limit. The experiment is to be performed as one of the first experiment in the J-PARC hadron facility (J-PARC E17). An overview and the present status of the experiment are presented.

  15. Measurement of neutron capture cross section of Li-7 at J-PARC / MLF / ANNRI

    SciTech Connect

    Makii, H.; Ota, S.; Nishinaka, I.; Nishio, I.; Segawa, M.; Kimura, A.; Harada, H.

    2014-05-02

    We have measured the {sup 7}Li(n,γ){sup 8}Li reaction at Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) installed at the Material and Life science experimental Facility in the Japan Proton Accelerator Research Complex (J-PARC / MLF). In this experiment, we used intense pulsed neutron beam provided by J-PARC / MLF and high performance Ge spectrometer, which is one of the main detectors of the ANNRI. We clearly detected γ rays from the {sup 7}Li(n,γ){sup 8}Li reaction with sufficient signal-to-noise ratio.

  16. Construction of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    SciTech Connect

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Ajima, Y.; Araoka, O.; Fujii, Y.; Hastings, N.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Sakashita, K.; Sugawara, S.; Suzuki, S.; Tanaka, K.; Tomaru, T.; Terashima, A.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; gupta, R.; Jain, A.; Muratore, J.; Parker, B.; Boussuge, T.; Charrier, J.-P.; Arakawa, M.; Ichihara, T.; Minato, T.; Okada, Y.; Itou, A.; Kumaki, T.; Nagami, M.; Takahashi, T.

    2009-10-18

    Following success of a prototype R&D, construction of a superconducting magnet system for J-PARC neutrino beam line has been carried out since 2005. A new conceptual beam line with the superconducting combined function magnets demonstrated the successful beam transport to the neutrino production target.

  17. TRACE/PARCS Core Modeling of a BWR/5 for Accident Analysis of ATWS Events

    SciTech Connect

    Cuadra A.; Baek J.; Cheng, L.; Aronson, A.; Diamond, D.; Yarsky, P.

    2013-11-10

    The TRACE/PARCS computational package [1, 2] isdesigned to be applicable to the analysis of light water reactor operational transients and accidents where the coupling between the neutron kinetics (PARCS) and the thermal-hydraulics and thermal-mechanics (TRACE) is important. TRACE/PARCS has been assessed for itsapplicability to anticipated transients without scram(ATWS) [3]. The challenge, addressed in this study, is to develop a sufficiently rigorous input model that would be acceptable for use in ATWS analysis. Two types of ATWS events were of interest, a turbine trip and a closure of main steam isolation valves (MSIVs). In the first type, initiated by turbine trip, the concern is that the core will become unstable and large power oscillations will occur. In the second type,initiated by MSIV closure,, the concern is the amount of energy being placed into containment and the resulting emergency depressurization. Two separate TRACE/PARCS models of a BWR/5 were developed to analyze these ATWS events at MELLLA+ (maximum extended load line limit plus)operating conditions. One model [4] was used for analysis of ATWS events leading to instability (ATWS-I);the other [5] for ATWS events leading to emergency depressurization (ATWS-ED). Both models included a large portion of the nuclear steam supply system and controls, and a detailed core model, presented henceforth.

  18. The LEM Experiment:. Measurement of Low Energy Spectrum at J-PARC On-Axis Neutrino Beam

    NASA Astrophysics Data System (ADS)

    Kaji, H.

    2013-03-01

    The LEM experiment measures the flux of J-PARC neutrino beam. We newly constructed the neutrino monitor, LEM, and installed at the J-PARC ND280 hall. We measure neutrino flux in the low energy part of on-axis direction. This part of the neutrino beam cannot be measured by any of T2K detectors. Therefore we can help further understandings of the J-PARC neutrino flux. The detailed design of detector is shown. In addition, the status of construction and installation at the ND280 hall is reported.

  19. Code Development in Coupled PARCS/RELAP5 for Supercritical Water Reactor

    DOE PAGES

    Hu, Po; Wilson, Paul

    2014-01-01

    The new capability is added to the existing coupled code package PARCS/RELAP5, in order to analyze SCWR design under supercritical pressure with the separated water coolant and moderator channels. This expansion is carried out on both codes. In PARCS, modification is focused on extending the water property tables to supercritical pressure, modifying the variable mapping input file and related code module for processing thermal-hydraulic information from separated coolant/moderator channels, and modifying neutronics feedback module to deal with the separated coolant/moderator channels. In RELAP5, modification is focused on incorporating more accurate water properties near SCWR operation/transient pressure and temperature in themore » code. Confirming tests of the modifications is presented and the major analyzing results from the extended codes package are summarized.« less

  20. Operational Experiences of J-PARC cryogenic hydrogen system for a spallation neutron source

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Aso, T.; Ohtsu, K.; Kawakami, Y.; Aoyagi, K.; Muto, H.

    2015-12-01

    The Japan Proton Accelerator Research Complex (J-PARC) cryogenic hydrogen system was completed in April 2008. The proton beam power was gradually increased to 500 kW. A trial 600-kW proton beam operation was successfully completed in April 2015. We achieved long-lasting operation for more than three months. However, thus far, we encountered several problems such as unstable operation of the helium refrigerator because of some impurities, failure of a welded bellows of an accumulator, and hydrogen pump issues. Furthermore, the Great East Japan Earthquake was experienced during the cryogenic hydrogen system operation in March 2011. In this study, we describe the operation characteristics and our experiences with the J-PARC cryogenic hydrogen system.

  1. The Application of DAQ-Middleware to the J-PARC E16 Experiment

    NASA Astrophysics Data System (ADS)

    Hamada, E.; Ikeno, M.; Kawama, D.; Morino, Y.; Nakai, W.; Obara, Y.; Ozawa, K.; Sendai, H.; Takahashi, T. N.; Tanaka, M. M.; Yokkaichi, S.

    2015-12-01

    DAQ-Middleware is a software framework for network-distributed data acquisition (DAQ) systems. We adopted the framework for the J-PARC E16 experiment, which requires a DAQ bandwidth of more than 660 MB/spill (two-second spill per six-second cycle). We developed a prototype for the DAQ software and confirmed that the prototype's total throughput satisfies the requirements of the experiment.

  2. Status of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    SciTech Connect

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Araoka, O.; Fugii, Y.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Olamura, T.; Sakashita, K.; Shibata, M.; Suzuki, S.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; Ghosh, A.; Muratore, J.; Parker, B.; Wanderer, P.

    2011-08-03

    The superconducting magnet system for the J-PARC neutrino beam line for the T2K experiment has been served for the beam operation without serious disturbance since April 2009. Present most concern of the system is the operational current limit of superconducting corrector magnets for beam steering due to systematic quenches at lower currents. Operational experience of the magnet system and examples of troubleshoot including countermeasures against the corrector magnet quenches are presented.

  3. Calpain-mediated Processing of p53-associated Parkin-like Cytoplasmic Protein (PARC) Affects Chemosensitivity of Human Ovarian Cancer Cells by Promoting p53 Subcellular Trafficking*

    PubMed Central

    Woo, Michael G.; Xue, Kai; Liu, Jiayin; McBride, Heidi; Tsang, Benjamin K.

    2012-01-01

    Resistance to cisplatin (CDDP)-based therapy is a major hurdle to the successful treatment of human ovarian cancer (OVCA), and the chemoresistant phenotype in OVCA cells is associated with Akt-attenuated p53-mediated apoptosis. Pro-apoptotic functions of p53 involve both transcription-dependent and -independent signaling pathways, and dysfunctional localization and/or inactivation of p53 contribute to the development of chemoresistance. PARC is a cytoplasmic protein regulating p53 subcellular localization and subsequent function. Little is known about the molecular mechanisms regulating PARC. Although PARC contains putative caspase-3 cleavage sites, and CDDP is known to induce the activation of caspases and calpains and induce proteasomal degradation of anti-apoptotic proteins, if and how PARC is regulated by CDDP in OVCA are unknown. Here, we present evidence that CDDP promotes calpain-mediated PARC down-regulation, mitochondrial and nuclear p53 accumulation, and apoptosis in chemosensitive but not resistant OVCA cells. Inhibition of Akt is required to sensitize chemoresistant cells to CDDP in a p53-dependent manner, an effect enhanced by PARC down-regulation. CDDP-induced PARC down-regulation is reversible by inhibition of calpain but not of caspases or the 26 S proteasome. Furthermore, in vitro experiments confirm the ability of calpain in mediating Ca2+-dependent PARC down-regulation. The role of Ca2+ in PARC down-regulation was further confirmed as ionomycin-induced PARC down-regulation in both chemosensitive and chemoresistant ovarian cancer cells. The data presented here implicate the regulation of p53 subcellular localization and apoptosis by PARC as a contributing factor in CDDP resistance in OVCA cells and Ca2+/calpain in PARC post-translational processing and chemosensitivity. PMID:22117079

  4. Auto-tuning systems for J-PARC LINAC RF cavities

    NASA Astrophysics Data System (ADS)

    Fang, Z.; Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S.; Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E.

    2014-12-01

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  5. D'une ouverture de la voyelle /epsilon/ en finale absolue en francais quebecois : analyse acoustique et perceptive

    NASA Astrophysics Data System (ADS)

    Riverin-Coutlee, Josiane

    Cette contribution est consacree a l'ouverture du /epsilon/ en finale absolue, un phenomene phonetique repute etre en declin en francais quebecois et caracteristique de locuteurs âges, peu scolarises, issus de milieux populaires et s'exprimant en situation de communication informelle. Une analyse acoustique de 480 voyelles /epsilon/ issues de la parole formelle de 40 jeunes etudiants universitaires originaires des centres urbains de Saguenay et de Quebec revele toutefois que le phenomene est encore bien vivant en francais quebecois et qu'il est plus frequent chez les locuteurs de Saguenay, une tendance validee auditivement par accord inter-juges. Les resultats d'un test de discrimination et d'identification mene aupres de 26 etudiants universitaires originaires de ces deux memes villes indiquent que les auditeurs naifs de Saguenay semblent moins sensibles a la variation et moins enclins a juger de l'origine geographique d'un locuteur a partir de sa prononciation de la voyelle /epsilon/ en fin de mot.

  6. L'enseignement du francais en Republique Federale d'Allemagne (The Teaching of French in the Federal Republic of Germany). L'enseignement du francais dans les classes terminales des lycees allemands (The Teaching of French in the Final Year in German Schools).

    ERIC Educational Resources Information Center

    Abel, Fritz; Lang, Jurgen

    Two papers describe two aspects of French foreign language instruction in West Germany. The first, "L'enseignement du francais en Republique Federale d'Allemagne" by Abel, deals with the institutional framework for French instruction in West Germany. A discussion of the instructional situation looks first at the history of French…

  7. L'enseignement modulaire et le laboratoire de langues: conception et experimentation d'un nouveau cours de francais oral au Centre d'anglais et de francais, Universite McGill (Modular Instruction and the Language Laboratory: Conception and Experimentation with a New Course in Oral French at the English and French Center, McGill University).

    ERIC Educational Resources Information Center

    Legoux, Marie-Noelle

    1980-01-01

    A modular-type course in French was developed at the "Centre d'anglais et de francais" at McGill University (Montreal) to meet the needs of incoming students who were lacking skills in listening and oral expression. The course is composed of eight modules a semester, each module corresponding to 15 to 20 hours work on the student's part. The…

  8. Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly1[OPEN

    PubMed Central

    Chen, Cheng; Froehlich, John E.; TerBush, Allan D.

    2016-01-01

    Chloroplast division is driven by the simultaneous constriction of the inner FtsZ ring (Z ring) and the outer DRP5B ring. The assembly and constriction of these rings in Arabidopsis (Arabidopsis thaliana) are coordinated partly through the inner envelope membrane protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS6 (ARC6). Previously, we showed that PARC6 (PARALOG OF ARC6), also in the inner envelope membrane, negatively regulates FtsZ assembly and acts downstream of ARC6 to position the outer envelope membrane protein PLASTID DIVISION1 (PDV1), which functions together with its paralog PDV2 to recruit DYNAMIN-RELATED PROTEIN 5B (DRP5B) from a cytosolic pool to the outer envelope membrane. However, whether PARC6, like ARC6, also functions in coordination of the chloroplast division contractile complexes was unknown. Here, we report a detailed topological analysis of Arabidopsis PARC6, which shows that PARC6 has a single transmembrane domain and a topology resembling that of ARC6. The newly identified stromal region of PARC6 interacts not only with ARC3, a direct inhibitor of Z-ring assembly, but also with the Z-ring protein FtsZ2. Overexpression of PARC6 inhibits FtsZ assembly in Arabidopsis but not in a heterologous yeast system (Schizosaccharomyces pombe), suggesting that the negative regulation of FtsZ assembly by PARC6 is a consequence of its interaction with ARC3. A conserved carboxyl-terminal peptide in FtsZ2 mediates FtsZ2 interaction with both PARC6 and ARC6. Consistent with its role in the positioning of PDV1, the intermembrane space regions of PARC6 and PDV1 interact. These findings provide new insights into the functions of PARC6 and suggest that PARC6 coordinates the inner Z ring and outer DRP5B ring through interaction with FtsZ2 and PDV1 during chloroplast division. PMID:26527658

  9. Characterization of a point mutation in the parC gene of Mycoplasma bovirhinis associated with fluoroquinolone resistance.

    PubMed

    Hirose, K; Kawasaki, Y; Kotani, K; Abiko, K; Sato, H

    2004-05-01

    Quinolone-resistant (QR) mutants of Mycoplasma bovirhinis strain PG43 (type strain) were generated by stepwise selection in increasing concentrations of enrofloxacin (ENR). An alteration was found in the quinolone resistance-determining region (QRDR) of the parC gene coding for the ParC subunit of topoisomerase IV from these mutants, but not in the gyrA, gyrB, and parE gene coding for the GyrA and GyrB subunits of DNA gyrase and the ParE subunit of topoisomerase IV. Similarly, such an alteration in QRDR of parC was found in the field isolates of M. bovirhinis, which possessed various levels of QR. The substitution of leucine (Leu) by serine (Ser) at position 80 of QRDR of ParC was observed in both QR-mutants and QR-isolates. This is the first report of QR based on a point mutation of the parC gene in M. bovirhinis.

  10. Association between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance

    PubMed Central

    Ardebili, Abdollah; Lari, Abdolaziz Rastegar; Beheshti, Maryam; Lari, Elnaz Rastegar

    2015-01-01

    Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyrA and parC genes. Results: The 44 and 4 isolates of A. baumannii exhibited full and intermediate-resistant to ciprofloxacin, respectively. Overall, the 42 isolates with double mutations of gyrA and parC genes showed a higher level of ciprofloxacin resistance than the 3 isolates with single mutations of gyrA or parC. Conclusion: Simultaneous mutations in gyrA and parC genes are expected to play a major role in high-level fluoroquinolone resistance in A. baumannii; albeit a single mutation in DNA topoisomerase IV could occasionally be associated with intermediate-resistance to these antimicrobials. PMID:26221488

  11. Rod-filter-field optimization of the J-PARC RF-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Ueno, A.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-01

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second-stage requirements of an H- ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H- ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). Although rod-filter-field (RFF) is indispensable and one of the most beam performance dominative parameters for the RF-driven H- ion source with the internal-antenna, the procedure to optimize it is not established. In order to optimize the RFF and establish the procedure, the beam performances of the J-PARC source with various types of rod-filter-magnets (RFMs) were measured. By changing RFM's gap length and gap number inside of the region projecting the antenna inner-diameter along the beam axis, the dependence of the H- ion beam intensity on the net 2MHz-RF power was optimized. Furthermore, the fine-tuning of RFM's cross-section (magnetmotive force) was indispensable for easy operation with the temperature (TPE) of the plasma electrode (PE) lower than 70°C, which minimizes the transverse emittances. The 5% reduction of RFM's cross-section decreased the time-constant to recover the cesium effects after an slightly excessive cesiation on the PE from several 10 minutes to several minutes for TPE around 60°C.

  12. Application of a generalized interface module to the coupling of PARCS with both RELAP5 and TRAC-M

    SciTech Connect

    Barber, D.A.; Wang, W.; Miller, R.M.; Downar, T.J.; Joo, H.G.; Mousseau, V.A.; Ebert, D.E.

    1999-04-01

    In an effort to more easily assess various combinations of 3-D neutronic/thermal-hydraulic codes, the USNRC has sponsored the development of a generalized interface module for the coupling of any thermal-hydraulics code to any spatial kinetics code. In this design, the thermal-hydraulics, general interface, and spatial kinetics codes function independently and utilize the Parallel Virtual Machine (PVM) software to manage inter-process communication. Using this interface, the USNRC version of the 3D neutron kinetics code, PARCS, has been coupled to the USNRC system analysis codes RELAP5 and TRAC-M. RELAP5/PARCS assessment results are presented for an OECD/NEA main steam line break benchmark problem. The assessment of TRAC-M/PARCS has only recently been initiated; nonetheless, the capabilities of the coupled code are presented for the OECD/NEA main steam line break benchmark problem.

  13. Prototype of network distributed control system for MLF/J-PARC

    NASA Astrophysics Data System (ADS)

    Nakatani, Takeshi; Nakajima, Kenji; Torii, Shuki; Bharoto; Higemoto, Wataru; Sato, Setsuo; Otomo, Toshiya; Arai, Masatoshi

    2006-11-01

    We have developed a prototype data acquisition and device control system for experiment instruments at the Material and Life science Facility (MLF)/Japan-Proton Accelerator Research Complex (J-PARC). The system employs distributed computing via Ethernet, client/server architecture, modular structure and a state machine. Communication between client and server software utilizes socket protocols over TCP/IP. We have deployed this prototype software in the network distributed control system by improving the data acquisition software used at KENS, introducing the system for the SWAN at KENS/KEK. It was kept in working order throughout 2 weeks of machine operation.

  14. Design and construction of the ultra-slow muon beamline at J-PARC/MUSE

    NASA Astrophysics Data System (ADS)

    Strasser, P.; Ikedo, Y.; Makimura, S.; Nakamura, J.; Nishiyama, K.; Shimomura, K.; Fujimori, H.; Adachi, T.; Koda, A.; Kawamura, N.; Kobayashi, Y.; Higemoto, W.; Ito, T. U.; Nagatomo, T.; Torikai, E.; Kadono, R.; Miyake, Y.

    2014-12-01

    At the J-PARC Muon Science Facility (MUSE), a new Ultra-Slow Muon beamline is being constructed to extend the μSR technique from bulk material to thin films, thus empowering a wide variety of surface and nano-science studies, and also a novel 3D imaging with the "ultra-slow muon microscope". Ultra-slow muons will be produced by the re-acceleration of thermal muons regenerated by the laser resonant ionization of muonium atoms evaporated from a hot tungsten foil, a method that originated from the Meson Science Laboratory at KEK. The design parameters, construction status and initial beam commissioning are reported.

  15. Quantum-gravity decoherence effects in neutrino oscillations: Expected constraints from CNGS and J-PARC

    SciTech Connect

    Mavromatos, Nick E.; Sarkar, Sarben; Meregaglia, Anselmo; Sakharov, Alexander S.

    2008-03-01

    Quantum decoherence, the evolution of pure states into mixed states, may be a feature of quantum-gravity models. In most cases, such models lead to fewer neutrinos of all active flavors being detected in a long-baseline experiment as compared to three-flavor standard neutrino oscillations. We discuss the potential of the CNGS and J-PARC beams in constraining models of quantum-gravity induced decoherence using neutrino oscillations as a probe. We use as much as possible model-independent parametrizations, even though they are motivated by specific microscopic models, for fits to the expected experimental data which yield bounds on quantum-gravity decoherence parameters.

  16. WebParc: a tool for analysis of the topography and volume of stroke from MRI

    PubMed Central

    Haselgrove, Christian; Makris, Nikos; Goldin, Donald M.; Lev, Michael H.; Caplan, David; Caviness, Verne S.

    2010-01-01

    The quantitative assessment of the anatomic consequences of cerebral infarction is critical in the study of the etiology and therapeutic response in patients with stroke. We present here an overview of the operation of “WebParc,” a computational system that provides measures of stroke lesion volume and location with respect to canonical forebrain neural systems nomenclature. Using a web-based interface, clinical imaging data can be registered to a template brain that contains a comprehensive set of anatomic structures. Upon delineation of the lesion, we can express the size and localization of the lesion in terms of the regions that are intersected within the template. We demonstrate the application of the system using MRI-based diffusion-weighted imaging and document measures of the validity and reliability of its uses. Intra- and inter-rater reliability is demonstrated, and characterized relative to the various classes of anatomic regions that can be assessed. The WebParc system has been developed to meet criteria of both efficiency and intuitive operator use in the real time analysis of stroke anatomy, so as to be useful in support of clinical care and clinical research studies. This article is an overview of its base-line operation with quantitative anatomic characterization of lesion size and location in terms of stroke distribution within the separate gray and white matter compartments of the brain. PMID:20077026

  17. Double hypernuclei experiment with hybrid emulsion method (J-PARC E07)

    NASA Astrophysics Data System (ADS)

    Ekawa, Hiroyuki; J-APRC E07 Collaboration

    2014-09-01

    Double hypernuclei are important probes to study the system with strangeness -2. In order to search for double hypernuclei, an upgrade experiment is planned at J-PARC K1.8 beam line. In the experiment, the KURAMA spectrometer system will detect Ξ- production in the (K- ,K+) reaction on a diamond target. SSDs located the upstream and the downstream of emulsion plates will record Ξ- tracks which flight toward emulsion plates precisely. Tracks in SSDs and emulsion will be automatically connected by a hybrid method. Discoveries of more than 10 new double hypernuclear species are expected, which enable us to discuss binding energy in terms of mass number dependence. On the other hand, we will also observe X rays from Ξ- atoms with a Germanium detector array installed close to the emulsion by tagging Ξ-stopped events. This will be the first measurement in the world and give information on the Ξ-potential shape at the nuclear surface region. Emulsion production has been completely done and a test experiment for some detectors of KURAMA spectrometer was carried out. In this talk, physics motivation and current status of the J-PARC E07 experiment will be reported.

  18. Measurement of Vector Meson Decays in Nuclei at J-PARC

    NASA Astrophysics Data System (ADS)

    Morino, Y.; Aoki, K.; Aramaki, Y.; En'yo, H.; Hamagaki, H.; Kanaya, J.; Kanno, K.; Kawama, D.; Kiyomichi, A.; Komatsu, Y.; Masumoto, S.; Murakami, H.; Muto, R.; Nakai, W.; Naruki, M.; Obara, Y.; Ozawa, K.; Sakuma, F.; Sawada, S.; Sekimoto, M.; Shibukawa, T.; Shigaki, K.; Takahashi, T. N.; Watanabe, Y. S.; Yokkaichi, S.

    Mass modification of vector meson has been studied in order to investigate the restoration of the chiral symmetry in hot and/or dense matter. Systematical measurement is necessary to confirm the mass modification due to the chiral symmetry restoration. For this purpose, E16 experiment at J-PARC will detect the vector mesons via e + e - decay. A goal of the E16 experiment is to reveal the target mass dependence and the meson velocity dependence of the mass modification through systematic measurement. For that purpose, it is aimed to collect slowly moving φ with typical β γ < 1.25 via di-electron decay as many as possible. The experiment will be performed at the high momentum beam line at J-PARC hadron hall, which supplies a 30-GeV proton beam with an intensity of 2 × 1010 protons per pulse. To cope with the high particle-rate environment, GEMs are used in the E16 spectrometer as the main detectors. To observe a possible second peak due to the modified mass of the φ inside nuclei, 5 MeV/c2 is our goal for the mass resolution. Preparation of the spectrometer construction is now in progress for the first beam time planned at 2016.

  19. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    SciTech Connect

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; March-Leuba, Jose A; Thurston, Carl; Hudson, Nathanael H.; Ireland, A.; Wysocki, A.

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, the capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.

  20. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    DOE PAGES

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; ...

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, themore » capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.« less

  1. Three-dimensional spiral injection scheme for the g-2/EDM experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Iinuma, Hiromi; Nakayama, Hisayoshi; Oide, Katsunobu; Sasaki, Ken-ichi; Saito, Naohito; Mibe, Tsutomu; Abe, Mitsushi

    2016-10-01

    A newly developed three-dimensional spiral injection scheme for beam insertion into a solenoidal storage ring is reported. A new planned muon g-2/EDM experiment at J-PARC aims to measure g - 2 to a factor of 5 better statistical precision and a factor of 100 better sensitivity for the electric dipole moment (EDM) measurement compared to previous experiments. The J-PARC experiment will use a 3-T MRI solenoid magnet as the muon storage ring with a 0.66 m diameter to achieve a 1-ppm level of local uniformity. The previous g - 2 injection scheme is not applicable for beam injection into a small ring. The new scheme provides a smooth injection utilizing a radial solenoidal fringe field, without causing an error field in the storage volume. The expected storage efficiency is 80% and over, which is to be compared to 3.5% for the previous g - 2 experiment. In addition, the ability to control the storage plane is important for the EDM measurement. In this paper, we introduce the conceptual design and required beam parameters in terms of Twiss functions and the expected injection efficiency.

  2. Evaluation of turbulence models in the PARC code for transonic diffuser flows

    NASA Technical Reports Server (NTRS)

    Georgiadis, N. J.; Drummond, J. E.; Leonard, B. P.

    1994-01-01

    Flows through a transonic diffuser were investigated with the PARC code using five turbulence models to determine the effects of turbulence model selection on flow prediction. Three of the turbulence models were algebraic models: Thomas (the standard algebraic turbulence model in PARC), Baldwin-Lomax, and Modified Mixing Length-Thomas (MMLT). The other two models were the low Reynolds number k-epsilon models of Chien and Speziale. Three diffuser flows, referred to as the no-shock, weak-shock, and strong-shock cases, were calculated with each model to conduct the evaluation. Pressure distributions, velocity profiles, locations of shocks, and maximum Mach numbers in the duct were the flow quantities compared. Overall, the Chien k-epsilon model was the most accurate of the five models when considering results obtained for all three cases. However, the MMLT model provided solutions as accurate as the Chien model for the no-shock and the weak-shock cases, at a substantially lower computational cost (measured in CPU time required to obtain converged solutions). The strong shock flow, which included a region of shock-induced flow separation, was only predicted well by the two k-epsilon models.

  3. Ultra slow muon microscopy by laser resonant ionization at J-PARC, MUSE

    NASA Astrophysics Data System (ADS)

    Miyake, Y.; Ikedo, Y.; Shimomura, K.; Strasser, P.; Kawamura, N.; Nishiyama, K.; Koda, A.; Fujimori, H.; Makimura, S.; Nakamura, J.; Nagatomo, T.; Kadono, R.; Torikai, E.; Iwasaki, M.; Wada, S.; Saito, N.; Okamura, K.; Yokoyama, K.; Ito, T.; Higemoto, W.

    2013-04-01

    As one of the principal muon beam line at the J-PARC muon facility (MUSE), we are now constructing a Muon beam line (U-Line), which consists of a large acceptance solenoid made of mineral insulation cables (MIC), a superconducting curved transport solenoid and superconducting axial focusing magnets. There, we can extract 2 × 108/s surface muons towards a hot tungsten target. At the U-Line, we are now establishing a new type of muon microscopy; a new technique with use of the intense ultra-slow muon source generated by resonant ionization of thermal Muonium (designated as Mu; consisting of a μ + and an e - ) atoms generated from the surface of the tungsten target. In this contribution, the latest status of the Ultra Slow Muon Microscopy project, fully funded, is reported.

  4. Diamond detector for beam profile monitoring in COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    &Cbreve; erv, M.; Sarin, P.; Pernegger, H.; Vageeswaran, P.; Griesmayer, E.

    2015-06-01

    We present the design and initial prototype results of a proton beam profile monitor for the COMET experiment at J-PARC. The goal of COMET is to look for charged lepton flavor violation by direct μ to e conversion at a sensitivity of 10-19. The 8 GeV proton beam pulsed at 100 ns with 1010 protons/s will be used to create muons through pion production and decay. In the final experiment, the proton flux will be raised to 1014 protons/s to increase the sensitivity. These requirements of harsh radiation tolerance and fast readout make diamond a good choice for constructing a beam profile monitor in COMET. We present first results of the characterization of single crystal diamond (scCVD) sourced from a new company 2A SYSTEMS Singapore. Our measurements indicate excellent charge collection and high carrier mobility down to cryogenic temperatures.

  5. Neutron Lifetime Measurement Initiated at J-PARC/MLF/BL05

    NASA Astrophysics Data System (ADS)

    Tanaka, Genki; Yoshioka, Tamaki; Otono, Hidetoshi; Sumi, Naoyuki; Yamashita, Satoru; Katayama, Ryo; Yamada, Takahito; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Shimizu, Hirohiko; Kitaguchi, Masaaki; Hirota, Katsuya; Sakakibara, Risa; Sugino, Tomoaki; Iwashita, Yoshihisa; Kitahara, Ryunosuke; Oide, Hideyuki; Shima, Tatsushi; Ino, Takashi; Mishima, Kenji; Taketani, Kaoru; Seki, Yoshichika; NOP Collaboration

    2014-09-01

    The neutron lifetime τn is one of the important parameters for the Big Bang Nucleosynthesis (BBN) which predicts an abundance of the light elements in the early universe. However, the He/(H+He) ratio recently measured by Izotov et al. has been deviated from that of the BBN prediction. Thus a precise τn measurement is desired. Historically, there are two methods for τn measurement, and there exists 3.8 σ deviation between their results. We are therefore conducting the τn measurement at the J-PARC/MLF/BL05 by using a third method. In this experiment we count the number of decay electrons by using Time Projection Chamber (TPC). We expect 1% accuracy with the collected data in JFY 2014. In this presentation, we will report some analysis results and future plan.

  6. Neutron lifetime measurement with pulsed beam at J- PARC: TPC and DAQ

    NASA Astrophysics Data System (ADS)

    Yamada, Takahito; Katayama, Ryo; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Yamashita, Satoru; Sakakibara, Risa; Sugino, Tomoaki; Kitaguchi, Masaaki; Hirota, Katsuya; Shimizu, Hirohiko M.; Tanaka, Genki; Sumi, Naoyukio; Otono, Hidetoshi; Yoshioka, Tamaki; Kitahara, Ryunosuke; Iwashita, Yoshihisa; Oide, Hideyuki; Shima, Tatsushi; Seki, Yoshichika; Mishima, Kenji; Taketani, Kaoru; Ino, Takashi; NOP Collaboration

    2014-09-01

    The neutron lifetime is an important parameter for Big Bang nucleosynthesis (BBN). The best neutron lifetime measurements have uncertainties at the 0.1% level; however, they differ by 3.8 sigma. In order to resolve this discrepancy, we plan to measure the neutron lifetime using a method originally developed by Kossakowski et al. which is different from the other 0.1% accuracy experiments. In our method, which uses a pulsed cold neutron beam at J-PARC, the electrons from the beta decay of the neutron are detected with a time projection chamber (TPC). A small amount of 3He is added to the gas mixture in order to simultaneously measure the neutron flux. We report on the recent upgrade of the TPC and the Data Acquisition System which were used to take data during the period of February-June 2014.

  7. New μSR spectrometer at J-PARC MUSE based on Kalliope detectors

    NASA Astrophysics Data System (ADS)

    Kojima, K. M.; Murakami, T.; Takahashi, Y.; Lee, H.; Suzuki, S. Y.; Koda, A.; Yamauchi, I.; Miyazaki, M.; Hiraishi, M.; Okabe, H.; Takeshita, S.; Kadono, R.; Ito, T.; Higemoto, W.; Kanda, S.; Fukao, Y.; Saito, N.; Saito, M.; Ikeno, M.; Uchida, T.; Tanaka, M. M.

    2014-12-01

    We developed a new positron detector system called Kalliope, which is based on multi-pixel avalanch photo-diode (m-APD), application specific integrated circuit (ASIC), field programmable gated array (FPGA) and ethernet-based SiTCP data transfer technology. We have manufactured a general-purpose spectrometer for muon spin relaxation (μSR) measurements, employing 40 Kalliope units (1280 channels of scintillators) installed in a 0.4 T longitudinal-field magnet. The spectrometer has been placed at D1 experimental area of J- PARC Muon Science Establishment (MUSE). Since February of 2014, the spectrometer has been used for the user programs of MUSE after a short commissioning period of one week. The data accumulation rate of the new spectrometer is 180 million positron events per hour (after taking the coincidence of two scintillators of telescopes) from a 20×20 mm sample for double-pulsed incoming muons.

  8. Modification of the PARC Navier-Stokes Code to predict rocket engine nozzle performance

    NASA Technical Reports Server (NTRS)

    Collins, Frank G.; Myruski, Bryan; Orr, Joseph L.

    1990-01-01

    The PARC2D Navier-Stokes Code was modified to compute the performance parameters for rocket engine nozzles. The perfect gas code was applied to the SSME engine nozzle for inviscid, laminar and turbulent flow. Inviscid computations compare well with Rocketdyne computations. Performance degradation due to the boundary layers is very reasonable. Application of the code to nontraditional nozzle geometries and to low Reynolds nozzles is demonstrated. Modification of the code for equilibrium H2/O2 chemistry is described. Thermodynamic and equilibrium constants are determined from statistical mechanics and the transport properties from exact kinetic theory, using collison integrals determined from appropriate intermolecular potentials. The equilibrium code was used to compute the SSME flowfield. Modifications of the flowfield due to the change of composition are described.

  9. Search for New Physics with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi; TREK/E36 Collaboration

    2016-03-01

    The E36 experiment conducted at J-PARC in Japan will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model (SM). The SM prediction for the ratio of leptonic K+ decays is very precise with an uncertainty of △RK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide clear indication of New Physics beyond the SM. The detector apparatus allows sensitivity to search for light U (1) gauge bosons and sterile neutrinos below 300 MeV /c2 , which could be associated with dark matter or explain established muon-related anomalies such as the muon g - 2 value, and perhaps the proton radius puzzle. The experiment was set up at the J-PARC K1.1BR kaon beamline in the fall of 2014, fully commissioned in the spring of 2015 and completed production data accumulation in Dec 2015. A scintillating fiber target was used to stop a beam of up to 1.2 Million K+ per spill. The K+ products were detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a CsI(TI) photon detector and particle ID systems. The status of the data analysis will be presented. This work has been supported by DOE awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  10. Wintertime component of the THORPEX Pacific-Asian Regional Campaign (T-PARC)

    NASA Astrophysics Data System (ADS)

    Song, Y.; Toth, Z.; Asuma, Y.; Reynolds, C.; Lngland, R.; Szunyogh, I.; Colle, B.; Chang, E.; Doyle, C.; Kats, A.

    2009-04-01

    The winter component of the T-PARC is an international field project that aims at improving high impact weather event forecasts for North America. The main objective is to understand how perturbations from the tropics, Eurasia and polar fronts travel through waveguide and turn into high impact weather events. Through adaptive observations by using manned aircrafts (NOAA G-IV and US Air force C-130s) and Russian rawinsonde network over data sparse regions, it is expected that accurate initial conditions will improve the numerical weather forecasts. Non-adaptive aircraft measurements over the Pacific Rim and part of India are also deployed through E-AMDAR program, which is expected to improve the background field over Asia where perturbations are initiated. The campaign is led by NOAA and joined by agencies and universities from US, Canada, Mexico, Japan, ECWMF, and Russia. While most observational data will be assimilated by operational centers to improve real time numerical weather predictions, post field studies will focus on aspects such as: data impact on forecast and analysis, dry and moist processes that affect the formation and propagation of perturbations, meso-scale storm structure, error growth, forecast "busts" under certain atmospheric regimes, and socio-economic applications such as costs and benefits of improved forecasts and their use by the public for high impact weather events. In particular, a Winter Olympics demonstration project (February 12 - February 28) is expected to be a test bed during winter T-PARC for real user outreach and application purposes. Effectiveness of existing targeting methods as well as new targeting methods in the 3-5 day lead time range will be pursued and other aspects related to data assimilation and numerical forecasts (both deterministic and ensemble forecasts) will be investigated within this project as well.

  11. HUMAN RIGHTS ASSESSMENT IN PARC JEAN MARIE VINCENT, PORT-AU-PRINCE, HAITI

    PubMed Central

    Cullen, Kimberly A.; Ivers, Louise C.

    2014-01-01

    Months after a 7.0 magnitude earthquake hit Port-au-Prince, Haiti, over one million remain homeless and living in spontaneous internally displaced person (IDP) camps. Billions of dollars from aid organizations and government agencies have been pledged toward the relief effort, yet many basic human needs, including food, shelter, and sanitation, continue to be unmet. The Sphere Project, “Humanitarian Charter and Minimum Standards in Disaster Response,” identifies the minimum standards to be attained in disaster response. From a human rights perspective and utilizing key indicators from the Sphere Project as benchmarks, this article reports on an assessment of the living conditions approximately 12 weeks after the earthquake in Parc Jean Marie Vincent, a spontaneous IDP camp in Port-au-Prince. A stratified random sample of households in the camp, proportionate to the number of families living in each sector, was selected. Interview questions were designed to serve as “key indicators” for the Sphere Project minimum standards. A total of 486 interviews were completed, representing approximately 5% of households in each of the five sectors of the camp. Our assessment identified the relative achievements and shortcomings in the provision of relief services in Parc Jean Marie Vincent. At the time of this survey, the Sphere Project minimum standards for access to health care and quantity of water per person per day were being met. Food, shelter, sanitation, and security were below minimum accepted standard and of major concern. The formal assessment reported here was completed by September 2010, and is necessarily limited to conditions in Haiti before the cholera outbreak in October. PMID:21178190

  12. Fine-tuning to minimize emittances of J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Oguri, H.

    2016-02-15

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H{sup −} ion source has been successfully operated for about one year. By the world’s brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. In order to minimize the transverse emittances, the rod-filter-field (RFF) was optimized by changing the triple-gap-lengths of each of pairing five piece rod-filter-magnets. The larger emittance degradation seems to be caused by impurity-gases than the RFF. The smaller beam-hole-diameter of the extraction electrode caused the more than expected improvements on not only the emittances but also the peak beam intensity.

  13. Detection of parC mutations in Streptococcus pneumoniae by Real-time PCR and Taqman-MGB probes.

    PubMed

    Alonso, Rodrigo; Mateo, Estibaliz; Cisterna, Ramón

    2007-04-01

    A Real-time PCR assay was developed by using Taqman-MGB probes to screen mutations at codons Ser79 and Asp83 of Streptococcus pneumoniae parC. One hundred and thirty levofloxacin-susceptible and forty-two levofloxacin-resistant clinical strains were assayed. Mutations at codon 79 were found among all the levofloxacin-resistant strains. Mutations at codon 79 or 83 were found in ten levofloxacin-susceptible strains. This procedure is a reliable method for a rapid detection of mutations in the QRDRs of parC gene of S. pneumoniae and could be carried out in a diagnostic laboratory for some high-risk patients or in epidemiological surveys.

  14. Upgrade of PARC2D to include real gas effects. [computer program for flowfield surrounding aeroassist flight experiment

    NASA Technical Reports Server (NTRS)

    Saladino, Anthony; Praharaj, Sarat C.; Collins, Frank G.; Seaford, C. Mark

    1990-01-01

    This paper presents a description of the changes and additions to the perfect gas PARC2D code to include chemical equilibrium effects, resulting in a code called PARCEQ2D. The work developed out of a need to have the capability of more accurately representing the flowfield surrounding the aeroassist flight experiment (AFE) vehicle. Use is made of the partition function of statistical mechanics in the evaluation of the thermochemical properties. This approach will allow the PARC code to be extended to thermal nonequilibrium when this task is undertaken in the future. The transport properties follow from formulae from the kinetic theory of gases. Results are presented for a two-dimensional AFE that compare perfect gas and real gas solutions at flight conditions, showing vast differences between the two cases.

  15. Improvements of Low Level RF Control Systems for J-PARC LINAC 400-MeV Upgrade

    NASA Astrophysics Data System (ADS)

    Fang, Z.; Futatsukawa, K.; Fukui, Y.; Kobayashi, T.; Michizono, S.; Sato, F.; Shinozaki, S.; Chishiro, E.

    The low level RF (LLRF) control systems have been successfully improved for the J-PARC LINAC upgrade. After the installation of 972-MHz high-β acceleration section behind the 324-MHz low-β section beginning in the summer of 2013, the proton beam was successfully accelerated to 400 MeV in January 2014. Many improvements in the LLRF control systems have been carried out to facilitate the operation of the J-PARC LINAC at 400 MeV. The reference 12-MHz signal delay settings for the feedback control systems have been optimized using 12-MHz delay modules. The stability performances of the 972-MHz RF&CLK (Clock) and Mixer&IQ (Mixer & IQ-modulator) boards have been improved using temperature-compensation techniques. By improving the hardware of the feedback control systems, very good stability of the RF systems has been achieved.

  16. Pre-conditioning procedure suitable for internal-RF-antenna of J-PARC RF-driven H⁻ ion source.

    PubMed

    Ueno, A; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Oguri, H

    2016-02-01

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H(-) ion source has been successfully operated for about 1 yr. By the world brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. Although no internal-RF-antenna failure, except for the once caused by an excess cesium due to a misoperation, occurred in the operation, many antennas failed in pre-conditionings for the first hundred days. The antenna failure rate was drastically decreased by using an antenna with coating thicker than a standard value and the pre-conditioning procedure repeating 15 min 25 kW RF-power operation and impurity-gas evacuation a few times, before the full power (50 kW) operation.

  17. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK Collaboration

    2014-09-01

    The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  18. PARC3D calculations of the F/A-18A HARV inlet vortex generators

    NASA Technical Reports Server (NTRS)

    Podleski, Steve D.

    1995-01-01

    NASA Lewis Research Center is currently engaged in a research effort as a team member of the High Alpha Technology Program within the NASA agency. This program uses a specially-equipped F/A-18A aircraft called the High Alpha Research Vehicle (HARV), in an effort to improve the maneuverability of high performance military aircraft at low-subsonic-speed, high-angle-of-attack conditions. The overall objective of the NASA Lewis effort is to develop inlet analysis technology towards efficient airflow delivery to the engine during these maneuvers. One portion of this inlet analysis technology uses computational fluid dynamics to predict installed inlet performance. Most of the F/A-18A HARV geometry, which includes the ramp/splitter plate, side diverter and slot, inlet lip and upper diverter, and deflected leading-edge flap has been modeled. The empennage and rear fuselage have not. A pair of vortex generators located on the bottom wall of the inlet were not modeled initially. These vortex generators were installed to alleviate any flow separation that may be induced by the wheel well protrusion into the inlet wall. Calculations completed with the PARC3D code showed that the pressure recovery has been underpredicted and the flow distortion over-predicted. To improve the correlation of PARC3D predictions with flight and wind tunnel tests, the vortex generators were included in the grid geometry and the results are presented in this report. The grid totals 27 blocks or 1.3 million grid points for the half model, which includes the vortex generator grid blocks. Two flight cases were calculated, a high speed case with a Mach number of 0.8 and angle of attack of 3.4; and a low speed case with a Mach number of 0.43 and angle of attack of 32.2. The vortex generators have a significant effect on the inlet boundary layers at high speed, low angle of attack; and have no effect at low speed, high angle of attack.

  19. Simulation and Track Reconstruction Techniques for the J-PARC muon g-2 experiment

    NASA Astrophysics Data System (ADS)

    Tsilias, Paschalis; Lee, Myeong Jae

    2017-03-01

    The Muon g-2/EDM proposed experiment at J-PARC is a promising and innovative attempt at the field of Precision Physics. The sensitivity goal of 0.1 ppm will test the limits of our current understanding, and may probe for Beyond the Standard Model observations. This paper seeks out to investigate the computational techniques required by the experiment. The GEANT4 [1] framework was used to simulate the detector setup, according to the experiment's Conceptual Design Report (CDR) [2]. This allowed to observe the event hierarchy in different energies, generate signal hit data, and construct an event-selection algorithm. ROOT and GDML enabled us to use the geometry and parsed output data in a platform-independent way. Using techniques pertaining to Machine Learning and Image Feature extraction, such as the Canny Edge detection and the Hough Transform, we were able to construct a generic representation of `track families' from each event category. Finally, the modular GENFIT2 [3] framework was used to implement the Kalman Filter [4] along with an Deterministic Annealing Filter (DAF) [5] and the Runge-Kutta stepper to reconstruct tracks from a few digitized, smeared singular event data.

  20. Computation of nozzle flow fields using the PARC2D Navier-Stokes code

    NASA Technical Reports Server (NTRS)

    Collins, Frank G.

    1986-01-01

    Supersonic nozzles which operate at low Reynolds numbers and have large expansion ratios have very thick boundary layers at their exit. This leads to a very strong viscous/inviscid interaction upon the flow within the nozzle and the traditional nozzle design techniques which correct the inviscid core with a boundary layer displacement do not accurately predict the nozzle exit conditions. A full Navier-Stokes code (PARC2D) was used to compute the nozzle flow field. Grids were generated using the interactive grid generator code TBGG. All computations were made on the NASA MSFC CRAY X-MP computer. Comparison was made between the computations and in-house wall pressure measurements for CO2 flow through a conical nozzle having an area ratio of 40. Satisfactory agreement existed between the computations and measurements for a stagnation pressure of 29.4 psia and stagnation temperature of 1060 R. However, agreement did not exist at a stagnation pressure of 7.4 psia. Several reasons for the lack of agreement are possible. The computational code assumed a constant gas gamma whereas gamma for CO2 varied from 1.22 in the plenum chamber to 1.38 at the nozzle exit. Finally, it is possible that condensation occurred during the expansion at the lower stagnation pressure.

  1. The origin of magnetic alloy core buckling in J-PARC 3 GeV RCS

    NASA Astrophysics Data System (ADS)

    Nomura, M.; Yamamoto, M.; Schnase, A.; Shimada, T.; Suzuki, H.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.

    2010-11-01

    We have been operating ten RF cavities loaded with magnetic alloy (MA) cores with a high field gradient of more than 20 kV/m in Japan Proton Accelerator Research Complex (J-PARC) 3 GeV Rapid Cycling Synchrotron (RCS) since September 2007. During 3 years operation, we detected three times the impedance reductions of RF cavities resulting from the buckling of MA cores. To find out the origin of the MA core buckling, we evaluated the thermal stress inside the MA cores in operation and studied the relationship between the MA core buckling and core structure. We figured out that the MA core buckling was caused by the thermal stress that was enhanced due to the impregnation with low viscosity epoxy resin. We improved the MA cores without the low viscosity epoxy resin impregnation and replaced all the cores in one RF cavity with them in March 2010. Up to now we operated the RF cavity loaded with the improved MA cores for 1500 h, it showed no impedance reduction and no buckling.

  2. Computation of Supersonic Jet Mixing Noise Using PARC Code With a kappa-epsilon Turbulence Model

    NASA Technical Reports Server (NTRS)

    Khavaran, A.; Kim, C. M.

    1999-01-01

    A number of modifications have been proposed in order to improve the jet noise prediction capabilities of the MGB code. This code which was developed at General Electric, employees the concept of acoustic analogy for the prediction of turbulent mixing noise. The source convection and also refraction of sound due to the shrouding effect of the mean flow are accounted for by incorporating the high frequency solution to Lilley's equation for cylindrical jets (Balsa and Mani). The broadband shock-associated noise is estimated using Harper-Bourne and Fisher's shock noise theory. The proposed modifications are aimed at improving the aerodynamic predictions (source/spectrum computations) and allowing for the non- axisymmetric effects in the jet plume and nozzle geometry (sound/flow interaction). In addition, recent advances in shock noise prediction as proposed by Tam can be employed to predict the shock-associated noise as an addition to the jet mixing noise when the flow is not perfectly expanded. Here we concentrate on the aerodynamic predictions using the PARC code with a k-E turbulence model and the ensuing turbulent mixing noise. The geometry under consideration is an axisymmetric convergent-divergent nozzle at its design operating conditions. Aerodynamic and acoustic computations are compared with data as well as predictions due to the original MGB model using Reichardt's aerodynamic theory.

  3. SUPERCONDUCTING COMBINED FUNCTION MAGNET SYSTEM FOR J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    OGITSU, T.; AJIMA, Y.; ANERELLA, M.; ESCALLIER, J.; GANETIS, G.; GUPTA, R.; HAGEDOM, D.; HARRISON, M.; HIGASHI, N.; IWAMOTO, Y.; ICHIKAWA, A.; JAIN, A.; KIMURA, N.; KOBAYASHI, T.; MAKIDA, Y.; MURATORE, J.; NAKAMOTO, T.; OHHATA, H.; TAKASAKI, N.; TANAKA, K.; TERASHIMA, A.; YAMOMOTO, A.; OBANA, T.; PARKER, B.; WANDERER, P.

    2004-10-03

    The J-PARC Neutrino Experiment, the construction of which starts in JFY 2004, will use a superconducting magnet system for its primary proton beam line. The system, which bends the 50 GeV 0.75 MW proton beam by about 80 degrees, consists of 28 superconducting combined function magnets. The magnets utilize single layer left/right asymmetric coils that generate a dipole field of 2.6 T and a quadrupole field of 18.6 T/m with the operation current of about 7.35 kA. The system also contains a few conduction cooled superconducting corrector magnets that serve as vertical and horizontal steering magnets. All the magnets are designed to provide a physical beam aperture of 130 mm in order to achieve a large beam acceptance. Extensive care is also required to achieve safe operation with the high power proton beam. The paper summarizes the system design as well as some safety analysis results.

  4. The Realignment of the Beamline for J-PARC 3 GeV RCS

    NASA Astrophysics Data System (ADS)

    Tani, Norio; Yamamoto, Masanobu; Kamiya, Junichiro; Hotchi, Hideaki; Kinsho, Michikazu

    J-PARC 3-GeV RCS suffered from the misalignments of several millimeters of the magnets in both horizontal and vertical directions caused by the Tohoku Region Pacific Coast Earthquake on 11th March, 2011. As the result of the orbit calculation showed that the beam loss was acceptable for beam operation at 300 kW, beam operation with the current placement was implemented until May, 2013. However according to the beam loss simulation, the beam loss increased and the horizontal emittance expanded at 1 MW operation. The collimator aperture of RCS was designed at 324 π mm mrad. The ring acceptance of RCS is 486 π mm mrad. The ring acceptance can secure good collimation efficiency of 97% by taking the aperture ratio which is 1.5 times of collimator aperture. The realignment of the RCS beamline must secure ring acceptance in order to perform the 1 MW operation. In this paper, the alignment results of the magnets and the ceramic chambers that constitute the beamline of 3-GeV RCS are reported.

  5. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK/E36 Collaboration

    2015-04-01

    The TREK/E36 experiment will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model. Simultaneously it will search for light U(1) gauge bosons and sterile neutrinos below 300 MeV/c2, which could be associated with dark matter or explain established muon-related anomalies such as the muon anomalous magnetic moment and the proton radius puzzle. The experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. It uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  6. The design of the radial collimator for residual stress analysis diffractometer of J-PARC

    NASA Astrophysics Data System (ADS)

    Torii, Shuki; Moriai, Atsushi

    2006-11-01

    Radial collimators are devices needed to define gauge sizes in neutron diffraction experiments. A design work of collimators needed for an engineering diffractometer that will be built at J-PARC is being progressed. Several collimators for different gauge sizes (1, 3, 5 mm, etc …) are going to be designed to define a gauge size range from 1 to 10 mm. An equation was established to express a relation between the gauge size and geometrical design parameters of the collimator, by applying a normal distribution curve to the error distribution of measured gauge size. Currently, the geometric calculations for several collimators have been finished. A prototype collimator for a gauge size of 1 mm was made and an FWHM (full width at half maximum) of the normal distribution of 1 mm was obtained from performance tests conducted at the neutron diffractometer for residual stress analysis RESA in JRR-3 (Japan Research Reactor-3) of Japan Atomic Energy Agency (JAEA). In addition, the performance test results are in a good agreement with results from a Monte Carlo simulation with the McStas using the design parameters.

  7. Neutron lifetime measurement with pulsed beam at J-PARC:Incident Beam Flux

    NASA Astrophysics Data System (ADS)

    Sakakibara, Risa; Shimizu, Hirohiko M.; Kitaguchi, Masaaki; Hirota, Katsuya; Sugino, Tomoaki; Yamashita, Satoru; Katayama, Ryo; Yamada, Takahito; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Yoshioka, Tamaki; Otono, Hidetoshi; Tanaka, Genki; Sumi, Naoyuki; Iwashita, Yoshihisa; Kitahara, Ryunosuke; Oide, Hideyuki; Shima, Tatsushi; Ino, Takashi; Mishima, Kenji; Taketani, Kaoru; Seki, Yoshichika; NOP Collaboration

    2014-09-01

    The neutron lifetime is one of the important parameters in the estimation of the abundance of the light elements in the early universe through the Big Bang Nucleosynthesis (BBN). The accuracy of 0.1% is desired in the neutron lifetime to quantitatively discuss the BBN in combination with the observation of the anisotropy of the cosmic microwave. We have started a lifetime measurement with pulsed neutrons at J-PARC/BL05. To measure the lifetime, we detect the decay electrons from the bunched neutrons and the incident neutron flux in the TPC at the same time. By diluting a small amount of 3He gas into the TPC, the incident flux is estimated by counting protons via 3He(n,p)3H reactions. The accuracy of the selection of 3He(n,p)3H events and the influence of the contamination of nitrogen gas are the major systematic errors. In this paper, the estimation of the systematic error in the incident flux is reported.

  8. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    SciTech Connect

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; Aronson, A.; Diamond, D.; Yarsky, P.

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculation pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.

  9. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    DOE PAGES

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; ...

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculationmore » pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.« less

  10. Design of hydrogen vent line for the cryogenic hydrogen system in J-PARC

    NASA Astrophysics Data System (ADS)

    Tatsumoto, Hideki; Aso, Tomokazu; Kato, Takashi; Ohtsu, Kiichi; Hasegawa, Shoichi; Maekawa, Fujio; Futakawa, Masatoshi

    2009-02-01

    As one of the main experimental facilities in J-PARC, an intense spallation neutron source (JSNS) driven by a 1-MW proton beam selected supercritical hydrogen at a temperature of 20 K and a pressure of 1.5 MPa as a moderator material. Moderators are controlled by a cryogenic hydrogen system that has a hydrogen relief system, which consists of high and low pressure stage of manifolds, a hydrogen vent line and a stack, in order to release hydrogen to the outside safely. The design of the hydrogen vent line should be considered to prevent purge nitrogen gas in the vent line from freezing when releasing the cryogenic hydrogen, to prevent moisture in the stack placed in an outdoor location from freezing, and to inhibit large piping temperature reduction at a building wall penetration. In this work, temperature change behaviors in the hydrogen vent line were analyzed by using a CFD code, STAR-CD. We determined required sizes of the vent line based on the analytical results and its layout in the building.

  11. Search for New Physics with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi H.; TREK Collaboration

    2016-09-01

    We are potentially standing at the precipice in searching for New Physics (NP) beyond the Standard Model (SM) by performing a precision test of lepton universality - a basic assumption of the SM that assigns an identical coupling constant to e, μ and τ. Experiment E36 conducted at J-PARC in Japan will test lepton universality in the RK = Γ (Ke 2) / Γ (Kμ 2) ratio. The SM prediction of leptonic K+ decays is highly precise with an uncertainty of △RK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide clear indication of NP beyond the SM. Although a successful description of the basic building blocks of matter, the SM is incomplete, falling short to describe dark matter, baryogenesis, neutrino masses and much more. The E36 detector apparatus allows sensitivity to search for light U (1) gauge bosons and sterile neutrinos, which could be associated with dark matter or explain established muon-related anomalies such as the muon g-2 value, and perhaps the proton radius puzzle. A scintillating fiber target was used to stop K+ beam. The K+ products were detected with large-acceptance toroidal spectrometer. Status of data analysis will be presented. This work has been supported by DOE Awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  12. Operational characteristics of the J-PARC cryogenic hydrogen system for a spallation neutron source

    SciTech Connect

    Tatsumoto, Hideki; Ohtsu, Kiichi; Aso, Tomokazu; Kawakami, Yoshihiko; Teshigawara, Makoto

    2014-01-29

    The J-PARC cryogenic hydrogen system provides supercritical hydrogen with the para-hydrogen concentration of more than 99 % and the temperature of less than 20 K to three moderators so as to provide cold pulsed neutron beams of a higher neutronic performance. Furthermore, the temperature fluctuation of the feed hydrogen stream is required to be within ± 0.25 K. A stable 300-kW proton beam operation has been carried out since November 2012. The para-hydrogen concentrations were measured during the cool-down process. It is confirmed that para-hydrogen always exists in the equilibrium concentration because of the installation of an ortho-para hydrogen convertor. Propagation characteristics of temperature fluctuation were measured by temporarily changing the heater power under off-beam condition to clarify the effects of a heater control for thermal compensation on the feed temperature fluctuation. The experimental data gave an allowable temperature fluctuation of ± 1.05 K. It is clarified through a 286-kW and a 524-kW proton beam operations that the heater control would be applicable for the 1-MW proton beam operation by extrapolating from the experimental data.

  13. Study for s-process using neutron beam provided from ANNRI of J-PARC

    NASA Astrophysics Data System (ADS)

    Hayakawa, Takehioto; Toh, Yosuke; Kimura, Akira; Nakamura, Shoji; Shizuma, Toshiyuki; Harada, Hideo

    2016-06-01

    Most isotopes heavier than iron are synthesized by the slow neutron capture reaction process (s-process) in stars. Isomers in stable isotopes have sometimes an important role as a branching point in nucleosynthesis flow in the s-process. An isomer with a half-life of 14.1 y in 113Cd is a branching point from which a nucleosynthesis flow reaches to a rare isotope 115Sn. The astrophysical origin of 115Sn has remained still an open question. The s-process abundance of 115Sn depends on the ratio of the 112Cd(n, γ) 113Cdm reaction cross section to the 112Cd(n, γ) 113Cdgs reaction cross section. However, the isomer production ratio following the neutron capture reaction has not been measured in the energy region higher than the thermal energy. An intense neutron beam experimental system, ANNRI, in J-PARC has a high purity germanium (HPGe) detector system consisting of two cluster detectors. We have measured γ-rays decaying to the ground state and the isomer using the HPGe detectors in conjunction with a time-offlight method at ANNRI.

  14. Fluoroquinolone Resistance Mutations in the parC, parE, and gyrA Genes of Clinical Isolates of Viridans Group Streptococci

    PubMed Central

    González, Irene; Georgiou, Marios; Alcaide, Fernando; Balas, Delia; Liñares, Josefina; de la Campa, Adela G.

    1998-01-01

    The nucleotide sequences of the quinolone resistance-determining regions (QRDRs) of the parC and gyrA genes from seven ciprofloxacin-resistant (Cpr) isolates of viridans group streptococci (two high-level Cpr Streptococcus oralis and five low-level Cpr Streptococcus mitis isolates) were determined and compared with those obtained from susceptible isolates. The nucleotide sequences of the QRDRs of the parE and gyrB genes from the five low-level Cpr S. mitis isolates and from the NCTC 12261 type strain were also analyzed. Four of these low-level Cpr isolates had changes affecting the subunits of DNA topoisomerase IV: three in Ser-79 (to Phe or Ile) of ParC and one in ParE at a position not previously described to be involved in quinolone resistance (Pro-424). One isolate did not show any mutation. The two high-level Cpr S. oralis isolates showed mutations affecting equivalent residue positions of ParC and GyrA, namely, Ser-79 to Phe and Ser-81 to Phe or Tyr, respectively. The parC mutations were able to transform Streptococcus pneumoniae to ciprofloxacin resistance, while the gyrA mutations transformed S. pneumoniae only when mutations in parC were present. These results suggest that DNA topoisomerase IV is a primary target of ciprofloxacin in viridans group streptococci, DNA gyrase being a secondary target. PMID:9797205

  15. Closeout Report - Search for Time Reversal Symmetry Violation with TREK at J-PARC

    SciTech Connect

    Kohl, Michael

    2015-04-15

    This DOE Early Career Award has enabled Dr. Michael Kohl to take on and expand his leadership roles in several projects such as TREK@J-PARC, OLYMPUS@DESY, MUSE@PSI, and in the experimental program in Hall C at Jefferson Lab. Dr. Kohl has successfully accomplished several items: (i) Preliminary results from SANE (E08-003) at Jefferson Lab: Former HU graduate student Anusha Liyanage has pursued her PhD research on SANE. Her analysis of the elastic ep scattering data has resulted in the extraction of the proton electric-to-magnetic form factor ratio from double spin asymmetries at the highest momentum transfer to date. The results are almost final and a publication is in preparation. (ii) Approval of TREK/E36 for running, preparation of simulation and analysis: the TREK experiment has been stage-II approved in fall 2013, has been mounted on the hall floor from November 2014 to April 2015, has been commissioned in April-June 2015 and is scheduled to run in fall 2015. The group has contributed significantly with simulations and magnetic field map calculations, has investigated the sensitivity of TREK to new light neutral particles, and contributed substantially to the mounting and commissioning of the experiment. (iii) Running of OLYMPUS and analysis: Under Dr. Kohl's leadership as spokesman, the OLYMPUS experiment has completed data taking beginning of 2013; calibrations and analysis have been well underway, with results to be expected in the course of 2015. (iv) Operation of GEM detectors at OLYMPUS and MUSE: The GEM telescopes built for OLYMPUS luminosity monitoring with forward-angle ep elastic scattering have been operated successfully, have meanwhile been relocated to PSI, and have been re-commissioned as beam particle trackers for the PSI secondary beams for MUSE. (v) Trained and prepared postdocs and graduate students for their future careers. Two postdocs from Dr. Kohl's group (Dr. Juergen Diefenbach and Dr. Peter Monaghan) have found permanent academic

  16. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC.

    PubMed

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-Ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-02-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm(3) in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4-4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm(3)) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research.

  17. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC

    PubMed Central

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-01-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm3 in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4–4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm3) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research. PMID:26937237

  18. New Physics search with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi H.; TREK Collaboration

    2017-01-01

    We are potentially standing at the precipice in the quest for discovery of New Physics (NP) beyond the SM by performing a precision test of lepton universality. Experiment E36 conducted at J-PARC in Japan tests lepton universality in the RK = Γ(Ke 2) / Γ(Kμ 2) ratio. In the SM, the ratio of leptonic K+ decays is highly precise with an uncertainty of ΔRK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide a clear indication of NP beyond the SM. The E36 detector apparatus allows sensitivity to search for sterile neutrinos below 300 MeV/c2 and light U(1) gauge bosons, which could be associated with dark matter or explain established muon-related anomalies such as the muon g-2 value, and perhaps the proton radius puzzle. E36 data taking was completed in 2015. A scintillating fiber target was used to stop a beam of up to 1.2 Million K+ per spill. K+ decay products were detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a CsI(Tl) photon calorimeter with large solid angle covering 75 % of 4 π and particle identification systems. The status of the data analysis will be presented. This work has been supported by DOE awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  19. Rod-filter-field optimization of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second-stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). Although rod-filter-field (RFF) is indispensable and one of the most beam performance dominative parameters for the RF-driven H{sup −} ion source with the internal-antenna, the procedure to optimize it is not established. In order to optimize the RFF and establish the procedure, the beam performances of the J-PARC source with various types of rod-filter-magnets (RFMs) were measured. By changing RFM’s gap length and gap number inside of the region projecting the antenna inner-diameter along the beam axis, the dependence of the H{sup −} ion beam intensity on the net 2MHz-RF power was optimized. Furthermore, the fine-tuning of RFM’s cross-section (magnetmotive force) was indispensable for easy operation with the temperature (T{sub PE}) of the plasma electrode (PE) lower than 70°C, which minimizes the transverse emittances. The 5% reduction of RFM’s cross-section decreased the time-constant to recover the cesium effects after an slightly excessive cesiation on the PE from several 10 minutes to several minutes for T{sub PE} around 60°C.

  20. Analysis of the OECD/NRC BWR Turbine Trip Transient Benchmark with the Coupled Thermal-Hydraulics and Neutronics Code TRAC-M/PARCS

    SciTech Connect

    Lee, Deokjung; Downar, Thomas J.; Ulses, Anthony; Akdeniz, Bedirhan; Ivanov, Kostadin N.

    2004-10-15

    An analysis of the Peach Bottom Unit 2 Turbine Trip 2 (TT2) experiment has been performed using the U.S. Nuclear Regulatory Commission coupled thermal-hydraulics and neutronics code TRAC-M/PARCS. The objective of the analysis was to assess the performance of TRAC-M/PARCS on a BWR transient with significance in two-phase flow and spatial variations of the neutron flux. TRAC-M/PARCS results are found to be in good agreement with measured plant data for both steady-state and transient phases of the benchmark. Additional analyses of four fictitious extreme scenarios are performed to provide a basis for code-to-code comparisons and comprehensive testing of the thermal-hydraulics/neutronics coupling. The obtained results of sensitivity studies on the effect of direct moderator heating on transient simulation indicate the importance of this modeling aspect.

  1. PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    ScienceCinema

    Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

    2016-07-12

    'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  2. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

    SciTech Connect

    Shibata, T. Ueno, A.; Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Naito, F.; Nishida, K.; Mochizuki, S.; Hatayama, A.; Mattei, S.; Lettry, J.

    2016-02-15

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30–120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  3. Studies of high density baryon matter with high intensity heavy-ion beams at J-PARC

    NASA Astrophysics Data System (ADS)

    Sako, H.; Harada, H.; Sakaguchi, T.; Chujo, T.; Esumi, S.; Gunji, T.; Hasegawa, S.; Hwang, S. H.; Ichikawa, Y.; Imai, K.; Itakura, K.; Kaneta, M.; Kim, B. C.; Kinsho, M.; Kitazawa, M.; Liu, Y.; Masui, H.; Nagamiya, S.; Nishio, K.; Okamura, M.; Oyama, K.; Ozawa, K.; Saha, P. K.; Sakaguchi, A.; Sato, S.; Shigaki, K.; Sugimura, H.; Tanida, K.; Tamura, J.; Tamura, H.; Nara, Y.; Saito, T. R.

    2016-12-01

    In J-PARC heavy-ion project, we aim at studies of QCD phase structures and hadron properties in high baryon density close to the neutron star core. We have developed a heavy-ion acceleration scheme with a new linac and a new booster with existing two synchrotrons with the goal beam rate of about 1011 Hz. We have also designed a large acceptance spectrometer based on a toroidal magnet. We have evaluated the spectrometer performance, and demonstrated reconstructing dielectron and dimuon spectra with full detector simulations. Finally, we designed a hypernuclear spectrometer which can utilize the full intensity ion beams.

  4. DESIGN OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    WANDERER,P.; ET AL.

    2003-06-15

    Superconducting combined function magnets will be utilized for the 50GeV-750kW proton beam line for the J-PARC neutrino experiment and an R and D program has been launched at KEK. The magnet is designed to provide a combined function with a dipole field of 2.59 T and a quadrupole field of 18.7 T/m in a coil aperture of 173.4 mm. A single layer coil is proposed to reduce the fabrication cost and the coil arrangement in the 2-D cross-section results in left-right asymmetry. This paper reports the design study of the magnet.

  5. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

    NASA Astrophysics Data System (ADS)

    Shibata, T.; Nishida, K.; Mochizuki, S.; Mattei, S.; Lettry, J.; Hatayama, A.; Ueno, A.; Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Naito, F.

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  6. The design and basic performance of a Spiral Fiber Tracker for the J-PARC E36 experiment

    NASA Astrophysics Data System (ADS)

    Mineev, O.; Bianchin, S.; Hasinoff, M. D.; Horie, K.; Igarashi, Y.; Imazato, J.; Ito, H.; Kawai, H.; Kodama, S.; Kohl, M.; Kudenko, Yu.; Shimizu, S.; Tabata, M.; Toyoda, A.; Yershov, N.

    2017-03-01

    A spiral fiber tracker (SFT) has been designed and produced for the J-PARC E36 experiment as an element of the tracking system for conducting a high-resolution momentum measurement of charged particles from kaon decays. A novel technique to wind the pre-made fiber ribbons spirally was employed for the configuration with four detector layers made of 1 mm diameter plastic scintillating fibers. Good position alignment and sufficiently high detection efficiency for charged particles with minimum ionizing energy were confirmed in cosmic ray test. The tracker was successfully used in the E36 experiment.

  7. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source.

    PubMed

    Shibata, T; Nishida, K; Mochizuki, S; Mattei, S; Lettry, J; Hatayama, A; Ueno, A; Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Naito, F

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  8. Emittance measurements for optimum operation of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The transverse emittances of the source were measured with various conditions to find out the optimum operation conditions minimizing the horizontal and vertical rms normalized emittances. The transverse emittances were most effectively reduced by operating the source with the plasma electrode temperature lower than 70°C. The optimum value of the cesium (Cs) density around the beam hole of the plasma electrode seems to be proportional to the plasma electrode temperature. The fine control of the Cs density is indispensable, since the emittances seem to increase proportionally to the excessiveness of the Cs density. Furthermore, the source should be operated with the Cs density beyond a threshold value, since the plasma meniscus shape and the ellipse parameters of the transverse emittances seem to be changed step-function-likely on the threshold Cs value.

  9. High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

    PubMed Central

    Janoir, C; Zeller, V; Kitzis, M D; Moreau, N J; Gutmann, L

    1996-01-01

    The mechanism of high-level fluoroquinolone resistance was studied in strains of Streptococcus pneumoniae, either selected in vitro or isolated from clinical samples. By using DNA from these high-level-resistant strains, low-level-resistant transformants (MIC of pefloxacin, > or = 32 micrograms/ml; MIC of ciprofloxacin, 4 micrograms/ml; MIC of sparfloxacin, 0.50 micrograms/ml) were obtained at high frequencies (ca.10(-2)), while high-level-resistant transformants (MIC of pefloxacin, > or = 64 micrograms/ml; MIC of ciprofloxacin, 16 to 64 micrograms/ml; MIC of sparfloxacin, > or = 8 micrograms/ml) were obtained only at low frequencies (ca.10(-4)). This suggested that mutations in at least two unlinked genes were necessary to obtain high-level resistance. Low-level resistance was associated with ParC mutations (change from Ser to Tyr at position 79 [Ser79Tyr], Ser79Phe, or Asp83Gly). ParC mutations were associated, in high-level-resistant strains and transformants, with alterations in the quinolone resistance-determining region of GyrA (Ser84Tyr, Ser84Phe, and/or Glu88Lys). Low-level resistance was shown to be necessary for expression of the gyrA mutations. No mutation in the region corresponding to the quinolone resistance-determining region of GyrB and no alteration of drug accumulation were found. PMID:9124836

  10. Tuning of RF amplitude and phase for the separate-type drift tube linac in J-PARC

    NASA Astrophysics Data System (ADS)

    Shen, Guobao; Ikegami, Masanori

    2009-01-01

    It is important to accurately adjust the amplitude and the phase of RF power sources for a high intensity proton linac. J-PARC (Japan proton accelerator research complex) linac is one of those high-intensity linacs. J-PARC linac has 30 SDTL (separate-type drift tube linac) tanks to accelerate the negative hydrogen ions from 50 to 181 MeV. Two neighboring SDTL tanks are driven by one klystron, where the phase and the amplitude of these two tanks are controlled in terms of the vector sum. The target-value of the vector sum control should be determined with a beam-based tuning for each klystron. During the beam commissioning, the RF tuning has been performed with a phase scan method introducing a concept of phase signature matching. In the tuning, the output beam energy from the SDTL module is monitored while scanning the RF phase. Comparing the obtained phase dependence of the output beam energy with those from a numerical model, the target-values for the low-level RF control system has been tuned within the required accuracy of 1° in phase and 1% in amplitude. The same tuning procedure has successfully been applied to the RF tuning of buncher and debuncher cavities.

  11. Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae

    PubMed Central

    Ferrándiz, María José; Fenoll, Asunción; Liñares, Josefina; De La Campa, Adela G.

    2000-01-01

    We have analyzed genetically three clinical isolates (3180, 3870, and 1244) of Streptococcus pneumoniae with high-level ciprofloxacin resistance. Isolates 3180 and 3870 were atypical because of their insolubility in deoxycholate. However, they hybridized specifically with pneumococcal autolysin and pneumolysin gene probes and have typical pneumococcal atpC and atpA gene sequences. Analysis of the complete sequences of the parC and gyrA genes revealed total variations of 8 and 8.7% (isolate 3180) and 7.4 and 3.6% (isolate 3870), respectively, compared to the wild-type strain R6 sequence. The variations observed between the sequences of R6 and isolate 1244 were less than 0.9%. The structure of the gyrA and parC genes from isolates 3180 and 3870 was organized in sequence blocks that show different levels of divergence, suggesting a pattern of recombination. These results are evidence for recombination at the fluoroquinolone target genes in clinical isolates of S. pneumoniae. The genetically related viridans group streptococci could act as a reservoir for fluoroquinolone resistance genes. PMID:10722479

  12. High-pressure beamline (PLANET) at the spallation neutron source, J-PARC (Invited)

    NASA Astrophysics Data System (ADS)

    Kagi, H.; Hattori, T.; Arima, H.; Utsumi, W. S.; Komatsu, K.; Nagai, T.; Yagi, T.

    2009-12-01

    Material and Life Science experimental Facility (MLF) of Japan Proton Accelerator Research Complex (J-PARC) will be one of the most powerful spallation neutron facilities in the world. The pulsed neutron source with a liquid Hg target is designed to be running at 25 Hz with a power of 1 MW. We have started the construction of the powder diffractometer dedicated to high-pressure experiments (PLANET) on BL-11. PLANET aims to study structures of hydrogen-bearing materials including dense hydrous minerals of the Earth’s deep interior, magmas and light element liquids. The instrument will realize diffraction and radiography experiments for powder and liquid/glass samples at high pressures up to 20 GPa and 2000 K using a large sized multi-anvil hydraulic press that can apply forces of ˜1500 ton. The instrument views a decoupled liquid H2 moderator with a cross section of 100 × 100 mm2. The primary and secondary fight paths are 25 m and 1.5 m, respectively. The 11.5-m-long supermirror guide with elliptical shape starts at a distance of 11.5 m from the moderator. Design of elliptical geometry is optimized by means of incorporating several different grade mirrors and linear approximation with planar guide in order to save cost for production without degradation of the intensity performance. The guide has a rectangular cross-section and consists of four walls coated with supermirror material. Sample is placed at 2 m from the guide exit. The 90° detectors will be installed at 1.5 m from the sample position. For the powder diffraction measurements using a multi-anvil press, an incident neutron beam passes through the vertical anvil gaps and irradiates the sample in the pressure medium. Diffracted neutrons go through the other anvil gaps at 90° direction. Half inch 3He linear position sensitive detectors with 600 mm length will be arranged horizontally and form these detector banks, which cover the scattering angle of 79° ≤ 2θ ≤ 101° and -35° ≤ Φ ≤ +35°. The

  13. New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible Streptococcus pneumoniae Isolates from France

    PubMed Central

    Decousser, Jean-Winoc; Methlouthi, Imen; Pina, Patrick; Collignon, Anne; Allouch, Pierre

    2006-01-01

    A real-time PCR assay with locked nucleic acid probes was developed to screen mutations at codons 79 and 83 of the Streptococcus pneumoniae parC gene. Only silent mutations were detected among 236 French invasive fluoroquinolone-susceptible strains. This test could be useful for some high-risk patients or in national surveys. PMID:16569894

  14. Mutations in the gyrB, parC, and parE genes of quinolone-resistant isolates and mutants of Edwardsiella tarda.

    PubMed

    Kim, Myoung Sug; Jun, Lyu Jin; Shin, Soon Bum; Park, Myoung Ae; Jung, Sung Hee; Kim, Kwangil; Moon, Kyung Ho; Jeong, Hyun Do

    2010-12-01

    The full length genes gyrB (2,415 bp), parC (2,277 bp), and parE (1,896 bp) in Edwardsiella tarda were cloned by PCR with degenerate primers based on the sequence of the respective quinolone resistance-determining region (QRDR), followed by elongation of 5' and 3' ends using cassette ligation-mediated PCR (CLMP). Analysis of the cloned genes revealed open reading frames (ORFs) encoding proteins of 804 (GyrB), 758 (ParC), and 631 (ParE) amino acids with conserved gyrase/topoisomerase features and motifs important for enzymatic function. The ORFs were preceded by putative promoters, ribosome binding sites, and inverted repeats with the potential to form cruciform structures for binding of DNA-binding proteins. When comparing the deduced amino acid sequences of E. tarda GyrB, ParC, and ParE with those of the corresponding proteins in other bacteria, they were found to be most closely related to Escherichia coli GyrB (87.6% identity), Klebsiella pneumoniae ParC (78.8% identity) and Salmonella typhimurium ParE (89.5% identity), respectively. The two topoisomerase genes, parC and parE, were found to be contiguous on the E. tarda chromosome. All 18 quinoloneresistant isolates obtained from Korea thus far did not contain subunit alternations apart from a substitution in GyrA (Ser83→Arg). However, an alteration in the QRDR of ParC (Ser84→Ile) following an amino acid substitution in GyrA (Asp87→Gly) was detected in E. tarda mutants selected in vitro at 8 microng/ml ciprofloxacin (CIP). A mutant with a GyrB (Ser464→Leu) and GyrA (Asp87→Gly) substitution did not show a significant increase in the minimum inhibitory concentration (MIC) of CIP. None of the in vitro mutants exhibited mutations in parE. Thus, gyrA and parC should be considered to be the primary and secondary targets, respectively, of quinolones in E. tarda.

  15. Vacuum tube operation analysis under multi-harmonic driving and heavy beam loading effect in J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Yamamoto, M.; Nomura, M.; Shimada, T.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.; Schnase, A.

    2016-11-01

    An rf cavity in the J-PARC RCS not only covers the frequency range of a fundamental acceleration pattern but also generates multi-harmonic rf voltage because it has a broadband impedance. However, analyzing the vacuum tube operation in the case of multi-harmonics is very complicated because many variables must be solved in a self-consistent manner. We developed a method to analyze the vacuum tube operation using a well-known formula and which includes the dependence on anode current for some variables. The calculation method is verified with beam tests, and the results indicate that it is efficient under condition of multi-harmonics with a heavy beam loading effect.

  16. Cryogenic System for J-Parc Neutrino Superconducting Magnet Beam LINE—DESIGN, Construction and Performance Test

    NASA Astrophysics Data System (ADS)

    Makida, Y.; Ohhata, H.; Okamura, T.; Suzuki, S.; Araoka, O.; Ogitsu, T.; Kimura, N.; Nakamoto, T.; Sasaki, K.; Kaneda, S.; Takahashi, T.; Ito, A.; Nagami, M.; Kumaki, T.; Nakashima, T.

    2010-04-01

    A helium cryogenic plant has been constructed in the proton accelerator research complex, J-PARC, to cool a string of superconducting magnets in the neutrino beam line since 2005. It consists of a screw compressor with a capacity of 160 g/s at 1.4 MPa, a 1.5 kW refrigerator, a centrifugal SHE pump with a flow rate of 300 g/s and peripherals. After system integration, performance tests have been carried out. In a preliminary cooling test without magnets, the cryogenic system attained a cooling capacity of 522 W by circulating supercritical helium flow of 300 g/s at 0.4 MPa and at 4.5 K. Afterwards a full system test with the magnets was carried out. The magnets were successfully charged up to an ultimate current of 5000 A beyond a nominal current of 4400 A. This paper describes the plant design and the result of performance measurements.

  17. SUPERCONDUCTING MAGNET SYSTEM AT THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    WANDERER,P.; ET AL.

    2003-06-15

    A neutrino oscillation experiment using the J-PARC SO GeV 0.75 MW proton beam is planned as a successor to the K2K project currently being operated at KEK. A superconducting magnet system is required for the arc section of the primary proton beam line to be within the space available at the site. A system with 28 combined function magnets is proposed to simplify the system and optimize the cost. The required fields for the magnets are 2.6 T dipole and 19 T/m quadrupole. The magnets are also required to have a large aperture, 173.4 mm diameter, to accommodate the large beam emittance. The magnets will be protected by cold diodes and cooled by forced flow supercritical helium produced by a 4.5 K, 2 {approx} 2.5 kW refrigerator. This paper reports the system overview and the design status.

  18. Current status of a time-of-flight single crystal neutron diffractometer SENJU at J-PARC

    NASA Astrophysics Data System (ADS)

    Tamura, I.; Oikawa, K.; Kawasaki, T.; Ohhara, T.; Kaneko, K.; Kiyanagi, R.; Kimura, H.; Takahashi, M.; Kiyotani, T.; Arai, M.; Noda, Y.; Ohshima, K.

    2012-02-01

    SENJU is a state-of-the-art single crystal time-of-flight Laue diffractometer in Materials and Life Science Experimental Facility at Japan Proton Accelerator Research Complex (J-PARC). The diffractometer is designed for precise crystal and magnetic structure analyses under multiple extreme conditions, such as low temperature, high-pressure, high-magnetic field. Measurements using small sample less than 1.0 mm3 will be also realized, which allows us to study wide variety of materials. SENJU is using a poisoned decoupled moderator to obtain peak profiles of Bragg reflection, and intensity distributions of superlattice reflections and diffuse scatterings with good accuracy. At the beginning, the diffractometer will have 31 two-dimensional scintillator detectors to cover wide area of reciprocal lattice space by a single measurement. The instrument is currently under construction and is scheduled to start on-beam commissioning in February 2012.

  19. Mars14 Monte Carlo simulation for the shielding studies of the J-PARC 3 GeV ring.

    PubMed

    Nakao, Noriaki; Mokhov, Nikolai; Yamamoto, Kazami; Irie, Yoshiro; Drozhdin, Alexander

    2005-01-01

    MARS14 Monte Carlo simulations were performed for collimation and shielding studies of the J-PARC 3 GeV synchrotron ring. The beam line module locations in the 348.3 m ring and the curved tunnel sections were described by the 'MAD-MARS beam line builder' tool. A 400 MeV proton beam loss distribution, calculated with the STRUCT code, was used as a 4 kW source term in the collimator region, with 1 kW source terms in the injection and extraction regions at 400 MeV and 3 GeV, respectively. Deep penetration calculations were carried out with good statistics using a newly developed three-dimensional multi-layer technique. Prompt dose-rate distributions were calculated inside and outside the concrete and soil shield up to the ground level. Using the calculation results obtained thus, an effective shielding design was made.

  20. High-power test of annular-ring coupled structures for the J-PARC linac energy upgrade

    NASA Astrophysics Data System (ADS)

    Tamura, Jun; Ao, Hiroyuki; Nemoto, Yasuo; Asano, Hiroyuki; Suzuki, Takahiro

    2015-02-01

    Annular-ring coupled structures (ACSs) will increase the beam energy of the Japan proton accelerator research complex (J-PARC) linac from 181 to 400 MeV to achieve a beam power of 1 MW for a materials and life science experimental facility. The mass production of the ACS cavities commenced in March 2009. Before the installation, all cavities require power testing. High-power testing is essential not only for confirming the cavity's design performance but also for preventing delays in cavity conditioning schedule. However, the 2011 Tohoku earthquake damaged J-PARC facilities, including the ACS power-test area, and cavity conditioning was interrupted for two years. After the facility's restoration, two ACS cavities (M01 and M11) were conditioned. They performed 15-20% above the designed accelerating field of 4.2 MV/m. As M01 was initially conditioned six years ago, the most recent conditioning time required for M01 was drastically reduced. From this result, we confirmed that long-term stored ACS cavities purged with nitrogen gas do not produce critical cavity performance issues. During high-power operation of M11, which is a unique cavity equipped with a capacitive iris in a waveguide, no significant increases in the temperature and the discharge rate around the capacitive iris were observed. Even considering beam loss due to residual gas scattering, the vacuum pressure was sufficiently low (4 × 10-6 Pa). More stable operation can be expected following a month-long conditioning process before the beam is commissioned. M11's conditioning successfully demonstrated an auto-conditioning program, and we established the conditioning scheme using this auto-conditioning program for all ACS cavities in a limited time and with limited manpower.

  1. Safety Related Investigations of the VVER-1000 Reactor Type by the Coupled Code System TRACE/PARCS

    NASA Astrophysics Data System (ADS)

    Jaeger, Wadim; Espinoza, Victor Hugo Sánchez; Lischke, Wolfgang

    This study was performed at the Institute of Reactor Safety at the Forschungszentrum Karlsruhe. It is embedded in the ongoing investigations of the international code assessment and maintenance program (CAMP) for qualification and validation of system codes like TRACE(1) and PARCS(2). The chosen reactor type used to validate these two codes was the Russian designed VVER-1000 because the OECD/NEA VVER-1000 Coolant Transient Benchmark Phase 2(3) includes detailed information of the Bulgarian nuclear power plant (NPP) Kozloduy unit 6. The post-test investigations of a coolant mixing experiment have shown that the predicted parameters (coolant temperature, pressure drop, etc.) are in good agreement with the measured data. The coolant mixing pattern, especially in the downcomer, has been also reproduced quiet well by TRACE. The coupled code system TRACE/PARCS which was applied on a postulated main steam line break (MSLB) provided good results compared to reference values and the ones of other participants of the benchmark. The results show that the developed three-dimensional nodalization of the reactor pressure vessel (RPV) is appropriate to describe the coolant mixing phenomena in the downcomer and the lower plenum of a VVER-1000 reactor. This phenomenon is a key issue for investigations of MSLB transient where the thermal hydraulics and the core neutronics are strongly linked. The simulation of the RPV and core behavior for postulated transients using the validated 3D TRACE RPV model, taking into account boundary conditions at vessel in- and outlet, indicates that the results are physically sound and in good agreement to other participant's results.

  2. Validation of the U.S. NRC coupled code system TRITON/TRACE/PARCS with the special power excursion reactor test III (SPERT III)

    SciTech Connect

    Wang, R. C.; Xu, Y.; Downar, T.; Hudson, N.

    2012-07-01

    The Special Power Excursion Reactor Test III (SPERT III) was a series of reactivity insertion experiments conducted in the 1950's. This paper describes the validation of the U.S. NRC Coupled Code system TRITON/PARCS/TRACE to simulate reactivity insertion accidents (RIA) by using several of the SPERT III tests. The work here used the SPERT III E-core configuration tests in which the RIA was initiated by ejecting a control rod. The resulting super-prompt reactivity excursion and negative reactivity feedback produced the familiar bell shaped power increase and decrease. The energy deposition during such a power peak has important safety consequences and provides validation basis for core coupled multi-physics codes. The transients of five separate tests are used to benchmark the PARCS/TRACE coupled code. The models were thoroughly validated using the original experiment documentation. (authors)

  3. Pre-conditioning procedure suitable for internal-RF-antenna of J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Oguri, H.

    2016-02-15

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H{sup −} ion source has been successfully operated for about 1 yr. By the world brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. Although no internal-RF-antenna failure, except for the once caused by an excess cesium due to a misoperation, occurred in the operation, many antennas failed in pre-conditionings for the first hundred days. The antenna failure rate was drastically decreased by using an antenna with coating thicker than a standard value and the pre-conditioning procedure repeating 15 min 25 kW RF-power operation and impurity-gas evacuation a few times, before the full power (50 kW) operation.

  4. Accessing proton generalized parton distributions and pion distribution amplitudes with the exclusive pion-induced Drell-Yan process at J-PARC

    NASA Astrophysics Data System (ADS)

    Sawada, Takahiro; Chang, Wen-Chen; Kumano, Shunzo; Peng, Jen-Chieh; Sawada, Shinya; Tanaka, Kazuhiro

    2016-06-01

    Generalized parton distributions (GPDs) encoding multidimensional information of hadron partonic structure appear as the building blocks in a factorized description of hard exclusive reactions. The nucleon GPDs have been accessed by deeply virtual Compton scattering and deeply virtual meson production with lepton beam. A complementary probe with hadron beam is the exclusive pion-induced Drell-Yan process. In this paper, we discuss recent theoretical advances on describing this process in terms of nucleon GPDs and pion distribution amplitudes. Furthermore, we address the feasibility of measuring the exclusive pion-induced Drell-Yan process π-p →μ+μ-n via a spectrometer at the High Momentum Beamline being constructed at J-PARC in Japan. Realization of such measurement at J-PARC will provide a new test of perturbative QCD descriptions of a novel class of hard exclusive reactions. It will also offer the possibility of experimentally accessing nucleon GPDs at large timelike virtuality.

  5. Study of the bar{K}-Nucleus Interaction by Using the 12C(K-, p) Reaction at J-PARC

    NASA Astrophysics Data System (ADS)

    Ichikawa, Yudai; Ahn, Jung Keun; Akazawa, Yuya; Aoki, Kanae; Botta, Elena; Ekawa, Hiroyuki; Evtoukhovitch, Petr; Feliciello, Alessandro; Fujita, Manami; Gogami, Toshiyuki; Hasegawa, Shoichi; Hasegawa, Tomoyuki; Hayakawa, Shuhei; Hayakawa, Tomonori; Honda, Ryotaro; Hosomi, Kenji; Imai, Ken'ichi; Jung, Wooseung; Kanatsuki, Shunsuke; Kim, Shinhyung; Kinbara, Shinji; Kobayashi, Kazuya; Lee, Jaeyong; Marcello, Simonetta; Miwa, Koji; Moon, Taejin; Nagae, Tomofumi; Nakada, Yoshiyuki; Nakagawa, Manami; Nanamura, Takuya; Naruki, Megumi; Sakaguchi, Atsushi; Sako, Hiroyuki; Sato, Susumu; Sasaki, Yuki; Shirotori, Kotaro; Sugimura, Hitoshi; Takahashi, Toshiyuki; Tamura, Hirokazu; Tanida, Kiyoshi; Tsamalaidze, Zviadi; Ukai, Mifuyu; Yamamoto, Takeshi. O.

    We have measured the inclusive missing-mass spectrum of the 12C(K-, p) reaction at a K- beam momentum of 1.8 GeV/c. This experiment was carried out as a by-product of a pilot run of the J-PARC E05 experiment, which was conceived to search Ξ-hypernuclei by using the (K-, K+) reaction at J-PARC K1.8 beam line. In present measurement, we study the bar{K}-nucleus interaction by comparing the observed missing-mass spectrum with a DWIA calculation. In a preliminary analysis, a "KINK" structure, which might be originated from the threshold of K-N → Σπ absorption, was found.

  6. Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland.

    PubMed

    Onizawa, Katsuhiro; Muramatsu, Takashi; Matsuki, Miwako; Ohta, Kazumasa; Matsuzaka, Kenichi; Oda, Yutaka; Shimono, Masaki

    2009-03-01

    We investigated cell response, including cell proliferation and expression of heat stress protein and bcl-2, to clarify the influence of low-level [gallium-aluminum-arsenide (Ga-Al-As) diode] laser irradiation on Par-C10 cells derived from the acinar cells of rat parotid glands. Furthermore, we also investigated amylase release and cell death from irradiation in acinar cells from rat parotid glands. The number of Par-C10 cells in the laser-irradiated groups was higher than that in the non-irradiated group at days 5 and 7, and the difference was statistically significant (P < 0.01). Greater expression of heat shock protein (HSP)25 and bcl-2 was seen on days 1 and 3 in the irradiated group. Assay of the released amylase showed no significant difference statistically between the irradiated group and the non-irradiated group. Trypan blue exclusion assay revealed that there was no difference in the ratio of dead to live cells between the irradiated and the non-irradiated groups. These results suggest that low-level laser irradiation promotes cell proliferation and expression of anti-apoptosis proteins in Par-C10 cells, but it does not significantly affect amylase secretion and does not induce rapid cell death in isolated acinar cells from rat parotid glands.

  7. Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria.

    PubMed

    Li, Shaoying; Li, Zhen; Wei, Wan; Ma, Chunyan; Song, Xiaomin; Li, Shufen; He, Wenying; Tian, Jianjun; Huo, Xiaoyan

    2015-02-01

    The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera Enterococcus and Lactobacillus isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in gyrA and parC genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on gyrA and parC of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in gyrA genes as there were 10 mutation sites in amino-acid sequences encoded by gyrA genes in 10 quinolone resistance strains and 14 mutation sites in Enterococcus durans HZ28, whereas no typical mutations were detected in parC genes.

  8. Relationship between mutations in parC and gyrA of clinical isolates of Streptococcus pneumoniae and resistance to ciprofloxacin and grepafloxacin.

    PubMed

    Stewart, B A; Johnson, A P; Woodford, N

    1999-12-01

    The mechanisms of resistance to ciprofloxacin and grepafloxacin were studied in 54 clinical isolates of Streptococcus pneumoniae. Restriction fragment length polymorphism analysis following HinfI digestion was used with DNA sequencing to identify mutations in the quinolone resistance-determining regions (QRDRs) of the parC and gyrA genes. Ciprofloxacin MICs up to 16 mg/L were not associated with mutations to these genes in approximately half of the isolates. In other isolates, moderate levels of ciprofloxacin resistance (MIC 8-16mg/L) were associated with an alteration of ParC, most commonly entailing replacement of serine-79 by phenylalanine. High-level ciprofloxacin resistance (MIC 32-128 mg/L) entailed the additional mutation of GyrA with substitution of serine-83 by phenylalanine. Grepafloxacin MICs >4 mg/L were associated with this GyrA mutation alone; no relationship was detected between grepafloxacin MICs and mutation of the QRDR of parC.

  9. Analysis of the Peach Bottom Turbine Trip 2 Experiment by Coupled RELAP5-PARCS Three-Dimensional Codes

    SciTech Connect

    Bousbia-Salah, Anis; Vedovi, Juswald; D'Auria, Francesco; Ivanov, Kostadin; Galassi, Giorgio

    2004-10-15

    Thanks to continuous progress in computer technology, it is now possible to perform best-estimate simulations of complex scenarios in nuclear power plants. This method is carried out through the coupling of three-dimensional (3-D) neutron modeling of a reactor core into system codes. It is particularly appropriate for transients that involve strong interactions between core neutronics and reactor loop thermal hydraulics. For this purpose, the Peach Bottom boiling water reactor turbine trip test was selected to challenge the capability of such coupled codes. The test is characterized by a power excursion induced by rapid core pressurization and a self-limiting course behavior. In order to perform the closest simulation, the coupled thermal-hydraulic system code RELAP5 and 3-D neutron kinetic code PARCS were used. The obtained results are compared to those available from experimental data. Overall, the coupled code calculations globally predict the most significant observed aspects of the transient, such as the pressure wave amplitude across the core and the power course, with an acceptable agreement. However, sensitivity studies revealed that more-accurate code models should be considered in order to better match the void dynamic and the cross-section variations during transient conditions.

  10. Event Recording Data Acquisition System and Experiment Data Management System for Neutron Experiments at MLF, J-PARC

    NASA Astrophysics Data System (ADS)

    Nakatani, T.; Inamura, Y.; Moriyama, K.; Ito, T.; Muto, S.; Otomo, T.

    Neutron scattering can be a powerful probe in the investigation of many phenomena in the materials and life sciences. The Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC) is a leading center of experimental neutron science and boasts one of the most intense pulsed neutron sources in the world. The MLF currently has 18 experimental instruments in operation that support a wide variety of users from across a range of research fields. The instruments include optical elements, sample environment apparatus and detector systems that are controlled and monitored electronically throughout an experiment. Signals from these components and those from the neutron source are converted into a digital format by the data acquisition (DAQ) electronics and recorded as time-tagged event data in the DAQ computers using "DAQ-Middleware". Operating in event mode, the DAQ system produces extremely large data files (˜GB) under various measurement conditions. Simultaneously, the measurement meta-data indicating each measurement condition is recorded in XML format by the MLF control software framework "IROHA". These measurement event data and meta-data are collected in the MLF common storage and cataloged by the MLF Experimental Database (MLF EXP-DB) based on a commercial XML database. The system provides a web interface for users to manage and remotely analyze experimental data.

  11. Designing an elliptical supermirror guide for the high-pressure material science beamline of J-PARC

    NASA Astrophysics Data System (ADS)

    Arima, Hiroshi; Komatsu, Kazuki; Ikeda, Kazuaki; Hirota, Katsuya; Kagi, Hiroyuki

    2009-02-01

    The design of an elliptical neutron guide for the time-of-flight (TOF) powder diffractometer of the high-pressure material science beamline at J-PARC was optimized using the McStas Monte Carlo simulation program to increase neutron flux for a small sample size. We investigated the analytical design in accordance with some requirements such as the gain factor at the small sample size and sufficient resolution at shorter wavelength of incident neutrons. The intensity and divergence with respect to energy dependence for elliptical guide designs were compared with those for the linearly tapered and straight guides. Optimizing the design of the elliptical guide results in the largest gain below 0.70 Å wavelength and gives constant instrumental resolution greater than 1 Å. The guide can support a flux gain of about 2.2 (high-intensity mode, Δ d/ d of ca. 0.6%) and 1.2 (high-resolution mode; Δ d/ d of ca. 0.5%) greater than 1 Å compared to the beamline of the natural flight path with resolution similar to that provided by the optimized elliptical guide.

  12. Development of a highly segmented scintillator hodoscope to construct intelligent trigger system for J-PARC E07

    NASA Astrophysics Data System (ADS)

    Oue, Kenichiro; Ekawa, Hiroyuki; Hwang, Sanghoon; Hosomi, Kenji; Hayakawa, Shuhei; Sakaguchi, Atsushi

    2014-09-01

    The purposes of J-PARC E07 are a systematic study of double Lambda hypernuclei with 10 times higher yields than the previous experiment (KEK-E373) and the first measurement of Ξ- atomic X-rays. In the experiment, we produce Ξ- via the quasi-free (K-,K+) reaction off a diamond target and expect to observe 104 stopped Ξ- (Ξ- atoms) in the emulsion counters. The (K-,K+) reaction is measured by using the KURAMA spectrometer and the acceptance of the KURAMA spectrometer is enlarged from the KEK-E373 experiment. So, a sophisticated online trigger system is inevitable to operate the new KURAMA spectrometer. We employ an intelligent three-dimensional matrix trigger system with a fine-beam-hodoscope (FBH), a highly segmented charge-hodoscope (CH) and a time-of-flight wall (TOF). The FBH is placed in the beamline, whereas CH is located at the upstream of the KURAMA magnet and TOF is located at the most downstream. The highly segmented CH consists of 64 segments, and each segment is made of a plastic scintillator 2 mm thickness, 11.5 mm width and 450 mm length. Scintillation light signals are read out with a wave-length-shifting fiber. Multi-pixel photon counters and front-end read-out EASIROC boards are used. The performance of CH is evaluated by using positron beams and cosmic rays. I will present the results of the performance studies of CH.

  13. Pressure Rise Analysis When Hydrogen Leak from a Cracked Pipe in the Cryogenic Hydrogen System in J-PARC

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Aso, T.; Hasegawa, S.; Ushijima, I.; Kato, T.; Ohtsu, K.; Ikeda, Y.

    2006-04-01

    As one of the main experimental facilities in the Japan Proton Accelerator Research Complex (J-PARC), an intense spallation neutron source (JSNS) driven by a 1 MW proton beam is being constructed. Cryogenic hydrogen at supercritical pressure is selected as a moderator. The total nuclear heating at the moderators is estimated to be a 3.7 kW. A hydrogen system to cool the moderators has been designed. The most severe off-normal event for the cryogenic hydrogen system is considered to be a hydrogen leak when a pipe cracks. In such a case, the hydrogen must be discharged to atmosphere quickly and safely. An analytical code that simulates the pressure change during a hydrogen leak was developed. A pressure rise analysis for various sized cracks was performed, and the required sizes for relief devices were determined. A safety valve size is φ42.7 mm and a rupture disc for vacuum layer should have a diameter of 37.1 mm, respectively.

  14. The St-Louis du Parc Heart Health Project: a critical analysis of the reverse effects on smoking

    PubMed Central

    Renaud, L; O'Loughlin, J; Dery, V

    2003-01-01

    Objectives: Although some school based smoking prevention programmes have shown positive impacts, others have had only short term effects, no effects, and in some cases reverse effects. The St-Louis du Parc Heart Health Project was a five year heart health promotion programme targeting children in eight elementary schools aged 9–12 years in disadvantaged multiethnic neighbourhoods in Montreal. In a controlled, longitudinal evaluation, the programme produced reverse effects on smoking—children exposed to the programme were more likely to initiate and to continue smoking than control children. This article explores hypotheses to explain the reverse effects. Design: Following work by an in-house committee, a consensus workshop with international experts was conducted to develop hypotheses to explain the reverse effects. This was complemented by an analysis of the programme's concordance with the standard guidelines on the school based prevention of tobacco use, and discussions with experts at the Centers for Disease Control and Prevention. Results: The programme respected most standard guidelines for smoking prevention programmes with respect to content and mode of delivery. Hypotheses to explain the reverse effects include: an unfavourable environment characterised by strong pro-smoking models and resistance to environmental interventions; heightened sensitivity to smoking among children most exposed to the programme; defence mechanisms among children stimulated by cognitive dissonance or anxiety; unanticipated effects associated with the health educator who delivered the programme; inadequate attention in programme development to the diverse cultural origins of the population targeted; and intervention content inappropriately targeted to children's stages of cognitive development. Conclusion: Elementary school based interventions should aim to develop a clear and coherent social norm about the non-use of tobacco, as a precursor to or in close conjunction with

  15. Maintenance and operation procedure, and feedback controls of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The maintenance and operation procedure to minimize the plasma chamber (PCH) replacement time on the beam line, which is very important to maximize the J-PARC beam time especially for an antenna failure, is presented in this paper. The PCH preserved by filling argon (Ar) gas inside after pre-conditioning including pre-cesiation to produce the required beam at a test-stand successfully produced the required beam on the beam line with slight addition of cesium (Cs). The methods of the feedback controls of a 2MHz-RF-matching, an H{sup −} ion beam intensity and the addition of Cs are also presented. The RF-matching feedback by using two vacuum variable capacitors (VVCs) and RF-frequency shift produced the almost perfect matching with negligibly small reflected RF-power. The H{sup −} ion beam intensity was controlled within errors of ±0.1mA by the RF-power feedback. The amount of Cs was also controlled by remotely opening a Cs-valve to keep the RF-power lower than a settled value.

  16. Substitutions of Ser83Leu in GyrA and Ser80Leu in ParC Associated with Quinolone Resistance in Acinetobacter pittii.

    PubMed

    Gu, Dan-xia; Hu, Yun-jian; Zhou, Hong-wei; Zhang, Rong; Chen, Gong-xiang

    2015-06-01

    To investigate the prevalence and the mechanism of quinolone-resistant Acinetobacter pittii, 634 Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolates were collected throughout Zhejiang Province. Identification of isolates was conducted by matrix-assisted laser desorption ionization/time of flight mass spectrometry (MALDI-TOF MS), blaOXA-51-like gene, and partial RNA polymerase β-subunit (rpoB) amplification. Twenty-seven isolates of A. pittii were identified. Among the 634 isolates, A. baumannii, A. pittii, Acinetobacter nosocomialis, and A. calcoaceticus counted for 87.22%, 4.26%, 8.20%, and 0.32%, respectively. Antimicrobial susceptibility of nalidixic acid, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, levofloxacin, sparfloxacin, moxifloxacin, and gatifloxacin for 27 A. pittii were determined by the agar dilution method. Detection of quinolone-resistant determining regions of gyrA, gyrB, parC, and parE was performed for the A. pittii isolates. In addition, plasmid-mediated quinolone resistance (PMQR) determinants (qnrA, qnrB, qnrS, qnrC, qnrD, aac(6')-Ib-cr, qepA, oqxA, and oqxB) were investigated. All the 27 isolates demonstrated a higher minimum inhibitory concentration (MIC) to old quinolones than the new fluoroquinolones. No mutation in gyrA, gyrB, parC, or parE was detected in 20 ciprofloxacin-susceptible isolates. Seven ciprofloxacin-resistant A. pittii were identified with a Ser83Leu mutation in GyrA. Among them, six isolates with simultaneous Ser83Leu amino acid substitution in GyrA and Ser80Leu in ParC displayed higher MIC values against ciprofloxacin. Additionally, three were identified with a Met370Ile substitution in ParE, and two were detected with a Tyr317His mutation in ParE, which were reported for the first time. No PMQR determinants were identified in the 27 A. pittii isolates. In conclusion, mutations in chromosome play a major role in quinolone resistance in A. pittii, while resistance mechanisms mediated by plasmid have

  17. EPA/IFP (Environmental Protection Agency/Institute Francais Du Petrole) European workshop on the emission of nitrous oxide from fossil-fuel combustion: Rueil-Malmaison, France, June 1-2, 1988

    SciTech Connect

    Ryan, J.V.; Srivastava, R.K.

    1989-10-01

    This report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil-fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increasing atmospheric N2O concentrations have been linked to depletion of stratospheric ozone (O3) and to global-climate warming. The combustion of fossil fuels has been identified as a potential major anthropogenic source of N2O. The workshop had two goals: (1) to exchange information among various international research and industrial groups that are involved in N2O chemistry, modeling, and measurement; and (2) to develop a network for coordinating future related efforts.

  18. In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

    PubMed

    Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

    2015-04-01

    Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan.

  19. Rare Kaon Decays, KEK experiment E391 and E14 at the Japan Physics and Accelerator Research Complex (J-PARC)

    SciTech Connect

    Wah, Yau Wai

    2012-12-06

    The goal of the J-PARC neutral kaon experiment (E14/KOTO) is to discover and measure the rate of the kaon rare decay to pi-zero and two neutrinos. This flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement (or depletion) to the branching ratio which in the Standard Model is accurately predicted within a few percent to be 2.8x10-11. The experiment is designed to observe more than 100 events at the Standard Model branching. It is a follow-up of the KEK E391a experiment and has stage-2 approval by J-PARC PAC in 2007. E14/KOTO has collaborators from Japan (Kyoto, Osaka, Yamagata, Saga), US (Arizona State, Chicago, Michigan Ann Arbor), Taiwan (National Taiwan), Korea, and Russia (Dubna). The experiment exploits the 300kW 30-50 GeV proton delivery of the J-PARC accelerator with a hermetic high acceptance detector with a fine grained Cesium Iodide (CsI) crystal calorimeter, and state of the art electronic front end and data acquisition system. With the recovery of the tsunami disaster on March 11th 2011, E14 is scheduled to start collecting data in December 2012. During the detector construction phase, Chicago focuses on the front end electronics readout of the entire detector system, particularly the CsI calorimeter. The CsI crystals together with its photomultipliers were previously used at the Fermilab KTeV experiment (E832/E799), and were loaned to E14 via this Chicago DOE support. The new readout electronics includes an innovative 10-pole pulse-shaping technique coupled with high speed digitization (14-bit 125MHz and 12-bit 500MHz). This new instrument enables us to measure both energy and timing, particularly with timing resolution better than 100 psec. Besides the cost saving by elimination of the standard time to digital converters, it is now possible to measure the momenta of the final state photons for additional background suppression

  20. Evaluation of Ciprofloxacin (gyrA, parC Genes) and Tetracycline (tetB Gene) Resistance in Nosocomial Acinetobacter baumannii Infections

    PubMed Central

    Nowroozi, Jamileh; Akhavan Sepahi, Abbas; Tahmasebinejad Kamarposhti, Lida; Razavipour, Roya; Mazhar, Flor

    2014-01-01

    Background: Acinetobacter baumannii plays an important role in some types of nosocomial infections as an opportunist microorganism which increases levels of resistance to antibacterial drugs and disinfectants. Objectives: The aim of this study was to determine the resistance and sensitivity of A. baumannii to different antibiotics and evaluate the minimal inhibitory concentration (MIC) for Ciprofloxacin and Tetracycline; in addition to Surfanios, Citron and Aniosyme DD1 disinfectants, and also to detect the presence of gyrA, parC and tetB gene bands in the isolates. Materials and Methods: In this study, 65 A. baumannii isolates were collected from the hospitalized patients in NIOC hospital (National Iranian Oil Company hospital) of Tehran, Iran during 2010-2011. The pattern of sensitivity to antibiotics was determined using CSLI disk diffusion and MIC methods. Furthermore, resistance of isolates to the common disinfectants (Surfanios Citron and Aniosyme DD1) was determined in different hospital wards. Presence of gyrA, parC and tetB gene bands was also detected by PCR method. Results: Frequency of Acinetobacter resistance to Amikacin, Ciprofloxacin, co-Trimoxazole, Ceftazidime and Ceftriaxone was 100% in the isolates reviewed in this study. The frequency of resistance to Gentamicin and Tetracycline were 86.1% in the isolates. The MIC of Ciprofloxacin in all (100%) of isolates was 32-64 μg/mL which showed the resistance to Ciprofloxacin In 86.1% of cases the Gentamicin and Tetracycline MIC were ≥ 16 μg/mL and in 13.9% of isolates the Gentamicin and Tetracycline MIC were 4 μg/mL, these results showed the resistance and sensitivity to the Gentamicin and Tetracycline, respectively. Additionally, all (100%) of the A. baumannii isolates were resistant to disinfectant concentrations, which were used with the methods recommended by manufacturers (0.5%). In 100% of the isolates parC and gyrA genes bands were detected, and tetB gene was also detected in 86.1% of

  1. Effects Due to the Structure and Materials of a Charge Stripping Foil on Activation of the RCS Injection Segment of J-PARC

    NASA Astrophysics Data System (ADS)

    Kato, Shuichi; Yamazaki, Yoshio; Yoshimoto, Masahiro; Kinsho, Michikazu; Sasao, Mamiko; Kenmotsu, Takahiro; Wada, Motoi

    Because of their robustness, Hybrid type thick Boron-doped Carbon (HBC) stripping foils are used in the 3 GeV Rapid Cycling Synchrotron (RCS) of Japan-Proton Accelerator Research Complex (J-PARC). The foil and the supporting structure are irradiated by H- beams. The activation of the surrounding structures and that of the foil itself is the problem to be solved. The ACAT (Atomic Collision in Amorphous Target) code has been modified to calculate the angle straggling of the transmission beam by multiple collisions in the foil. The results did not show any substantial deterioration of the beam optics due to the foil. The gamma spectra measured during a shutdown period of the RCS has been analyzed to see the correlation with the beam transport in the system.

  2. Fabrication of silica aerogel with n=1.08 for e+ /μ+ separation in a threshold Cherenkov counter of the J-PARC TREK/E36 experiment

    NASA Astrophysics Data System (ADS)

    Tabata, Makoto; Toyoda, Akihisa; Kawai, Hideyuki; Igarashi, Youichi; Imazato, Jun; Shimizu, Suguru; Yamazaki, Hirohito

    2015-09-01

    This study presents the development of hydrophobic silica aerogel for use as a radiator in threshold-type Cherenkov counters. These counters are to be used for separating positrons and positive muons produced by kaon decay in the J-PARC TREK/E36 experiment. We chose to employ aerogel with a refractive index of 1.08 to identify charged particles with momenta of approximately 240 MeV/c, and the radiator block shape was designed with a trapezoidal cross-section to fit the barrel region surrounding the kaon stopping target in the center of the TREK/E36 detector system. Including spares, we obtained 30 crack-free aerogel blocks segmented into two layers, each layer having a thickness of 2 cm and a length of 18 cm, to fill 12 counter modules. Optical measurements showed that the produced aerogel tiles had the required refractive indices and transparency.

  3. Development of Hyperon Time-Projection-Chamber (HypTPC) for the H-Dibaryon Search Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Hwang, Sanghoon; Imai, Kenichi; Ahn, Jung Keun

    We the E42 collaboration proposed to search for the H-dibaryon in ΛΛ production from (K-, K-) reaction off nuclei by using a high-intensity K- beam at J-PARC with 100 times better statistics than KEK-E224 and E552 experiments. Our proposed experiment will be designed to confirm if the enhancement is due to the H-dibaryon as a ΛΛ resonance or a virtual bound state or ΛΛ final state interaction. We plan to construct a large-acceptance hyperon spectrometer with a Time-Projection-Chamber (HypTPC) to detector ΛΛ particles, simultaneously K+ particle is measured by the KURAMA spectrometer. We expect to collect 11000 ΛΛ events with a mass resolution of 1.0 MeV/c2 near the ΛΛ threshold. The sensitivity of the detector shows two orders of magitude improvement from the present limit.

  4. Update on the Intercontinental Cooperative ITP Study Group (ICIS) and on the Pediatric and Adult Registry on Chronic ITP (PARC ITP).

    PubMed

    Kühne, Thomas

    2013-01-01

    The Intercontinental Cooperative ITP Study Group (ICIS) was founded in 1997, when the American practice guidelines demonstrated that there is a substantial lack of clinical data. The aim of the group was to promote basic science and clinical research in the field of ITP. Clinical data and more recently DNA is collected to investigate children and adults with ITP. ICIS organizes regular meetings and opened several registries, the most recent being the Pediatric and Adult Registry on Chronic ITP (PARC-ITP), all of which will be briefly discussed. There are many unanswered questions in basic science and clinical research in ITP which need large collaborative studies. The international network of ICIS may be of value in better understanding ITP.

  5. Analysis of a rod withdrawal in a PWR core with the neutronic- thermalhydraulic coupled code RELAP/PARCS and RELAP/VALKIN

    SciTech Connect

    Miro, R.; Maggini, F.; Barrachina, T.; Verdu, G.; Gomez, A.; Ortego, A.; Murillo, J. C.

    2006-07-01

    The Reactor Ejection Accident (REA) belongs to the Reactor Initiated Accidents (RIA) category of accidents and it is part of the licensing basis accident analyses required for pressure water reactors (PWR). The REA at hot zero power (HZP) is characterized by a single rod ejection from a core position with a very low power level. The evolution consists basically of a continuous reactivity insertion. The main feature limiting the consequences of the accident in a PWR is the Doppler Effect. To check the performance of the coupled code RELAP5/PARCS2.5 and RELAP5/VALKIN a REA in Trillo NPP is simulated. These analyses will allow knowing more accurately the PWR real plant phenomenology in the RIA most limiting conditions. (authors)

  6. Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

    PubMed Central

    Le Carrou, J.; Laurentie, M.; Kobisch, M.; Gautier-Bouchardon, A. V.

    2006-01-01

    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser80→Phe and Asp84→Asn), and one point mutation was observed just behind the QRDR of ParC (Ala116→Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC. PMID:16723552

  7. Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene.

    PubMed

    Le Carrou, J; Laurentie, M; Kobisch, M; Gautier-Bouchardon, A V

    2006-06-01

    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser80-->Phe and Asp84-->Asn), and one point mutation was observed just behind the QRDR of ParC (Ala116-->Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC.

  8. Amino acid substitutions in gyrA and parC associated with quinolone resistance in nalidixic acid-resistant Salmonella isolates

    PubMed Central

    2013-01-01

    This study was undertaken to identify and characterize amino acid substitutions in gyrA and parC related with quinolone resistance of 27 nalidixic acid-resistant (NaR) Salmonella isolates collected in poultry slaughterhouses in Korea. A total of 51 Salmonella isolates were detected from 44.8% (47/105) of the total samples from 15 poultry slaughterhouses examined, among which 27 (52.9%) NaR isolates were detected while ciprofloxacin (Cip) resistance was not present in the isolates. These 27 NaR isolates of DNA sequencing revealed that it contained three types of gyrA mutations in only D87 codon. Mutations in the D87 codon resulted in substitutions to G in most of the isolates, but D87Y and D87N exchanges were also detected. Although Cip resistance was absent, reduced susceptibility characterized by mutations in gyrA was apparent among Salmonella isolates from poultry slaughterhouses in Korea. PMID:24237626

  9. Physics potential of a long-baseline neutrino oscillation experiment using a J-PARC neutrino beam and Hyper-Kamiokande

    NASA Astrophysics Data System (ADS)

    Abe, K.; Aihara, H.; Andreopoulos, C.; Anghel, I.; Ariga, A.; Ariga, T.; Asfandiyarov, R.; Askins, M.; Back, J. J.; Ballett, P.; Barbi, M.; Barker, G. J.; Barr, G.; Bay, F.; Beltrame, P.; Berardi, V.; Bergevin, M.; Berkman, S.; Berry, T.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bolognesi, S.; Boyd, S. B.; Bravar, A.; Bronner, C.; Cafagna, F. S.; Carminati, G.; Cartwright, S. L.; Catanesi, M. G.; Choi, K.; Choi, J. H.; Collazuol, G.; Cowan, G.; Cremonesi, L.; Davies, G.; De Rosa, G.; Densham, C.; Detwiler, J.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Emery, S.; Ereditato, A.; Fernández, P.; Feusels, T.; Finch, A.; Fitton, M.; Friend, M.; Fujii, Y.; Fukuda, Y.; Fukuda, D.; Galymov, V.; Ganezer, K.; Gonin, M.; Gumplinger, P.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haga, Y.; Hartfiel, B.; Hartz, M.; Hayato, Y.; Hierholzer, M.; Hill, J.; Himmel, A.; Hirota, S.; Horiuchi, S.; Huang, K.; Ichikawa, A. K.; Iijima, T.; Ikeda, M.; Imber, J.; Inoue, K.; Insler, J.; Intonti, R. A.; Irvine, T.; Ishida, T.; Ishino, H.; Ishitsuka, M.; Itow, Y.; Izmaylov, A.; Jamieson, B.; Jang, H. I.; Jiang, M.; Joo, K. K.; Jung, C. K.; Kaboth, A.; Kajita, T.; Kameda, J.; Karadhzov, Y.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kim, J. Y.; Kim, S. B.; Kishimoto, Y.; Kobayashi, T.; Koga, M.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koshio, Y.; Kropp, W. R.; Kudenko, Y.; Kutter, T.; Kuze, M.; Labarga, L.; Lagoda, J.; Laveder, M.; Lawe, M.; Learned, J. G.; Lim, I. T.; Lindner, T.; Longhin, A.; Ludovici, L.; Ma, W.; Magaletti, L.; Mahn, K.; Malek, M.; Mariani, C.; Marti, L.; Martin, J. F.; Martin, C.; Martins, P. P. J.; Mazzucato, E.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mezzetto, M.; Minakata, H.; Minamino, A.; Mine, S.; Mineev, O.; Miura, M.; Monroe, J.; Mori, T.; Moriyama, S.; Mueller, T.; Muheim, F.; Nakahata, M.; Nakamura, K.; Nakaya, T.; Nakayama, S.; Needham, M.; Nicholls, T.; Nirkko, M.; Nishimura, Y.; Noah, E.; Nowak, J.; Nunokawa, H.; O'Keeffe, H. M.; Okajima, Y.; Okumura, K.; Oser, S. M.; O'Sullivan, E.; Ovsiannikova, T.; Owen, R. A.; Oyama, Y.; Pérez, J.; Pac, M. Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Perevozchikov, O.; Perkin, J. D.; Pistillo, C.; Playfer, S.; Posiadala-Zezula, M.; Poutissou, J.-M.; Quilain, B.; Quinto, M.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A.; Redij, A.; Retiere, F.; Riccio, C.; Richard, E.; Rondio, E.; Rose, H. J.; Ross-Lonergan, M.; Rott, C.; Rountree, S. D.; Rubbia, A.; Sacco, R.; Sakuda, M.; Sanchez, M. C.; Scantamburlo, E.; Scholberg, K.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Shaikhiev, A.; Shimizu, I.; Shiozawa, M.; Short, S.; Sinnis, G.; Smy, M. B.; Sobczyk, J.; Sobel, H. W.; Stewart, T.; Stone, J. L.; Suda, Y.; Suzuki, Y.; Suzuki, A. T.; Svoboda, R.; Tacik, R.; Takeda, A.; Taketa, A.; Takeuchi, Y.; Tanaka, H. A.; Tanaka, H. K. M.; Tanaka, H.; Terri, R.; Thompson, L. F.; Thorpe, M.; Tobayama, S.; Tolich, N.; Tomura, T.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vagins, M. R.; Vasseur, G.; Vogelaar, R. B.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilson, J. R.; Xin, T.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Zito, M.

    2015-05-01

    Hyper-Kamiokande will be a next-generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of CP asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams. In this paper, the physics potential of a long-baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis uses the framework and systematic uncertainties derived from the ongoing T2K experiment. With a total exposure of 7.5 MW × 10^7s integrated proton beam power (corresponding to 1.56 × 10^{22} protons on target with a 30 GeV proton beam) to a 2.5^circ off-axis neutrino beam, it is expected that the leptonic CP phase δ _{CP} can be determined to better than 19 degrees for all possible values of δ _{CP}, and CP violation can be established with a statistical significance of more than 3 σ (5 σ) for 76{%} (58{%}) of the {δ _{CP}} parameter space. Using both ν _e appearance and ν _μ disappearance data, the expected 1σ uncertainty of sin ^2θ _{23} is 0.015(0.006) for sin ^2θ _{23}=0.5(0.45).

  10. Measurement of the isomer production ratio for the 112Cd(n ,γ )113Cd reaction using neutron beams at J-PARC

    NASA Astrophysics Data System (ADS)

    Hayakawa, T.; Toh, Y.; Huang, M.; Shizuma, T.; Kimura, A.; Nakamura, S.; Harada, H.; Iwamoto, N.; Chiba, S.; Kajino, T.

    2016-11-01

    The astrophysical origin of a rare isotope 115Sn remains an open question. An isomer (T1 /2=14.1 y ) in 113Cd is an s -process branching point from which a nucleosynthesis flow reaches 115Sn. The s -process abundance of 115Sn depends on the isomer production ratio in the 112Cd(n ,γ )113Cd reaction. However, the ratio has not been measured in an energy region higher than the thermal energy. We have measured γ rays following neutron capture reactions on 112Cd using two cluster high-purity germanium (HPGe) detectors in conjunction with a time-of-flight method at J-PARC. We have obtained the result that the relative γ -ray intensity ratio of the isomer is almost constant in an energy region of up to 5 keV. This result suggests that the s -process contribution to the solar abundance of 115Sn is minor. We have found that the ratio of a resonance at 737 eV is about 1.5 times higher than other ratios. This enhancement can be explained by a p -wave neutron capture. This result suggests measurements of decay γ rays to isomers are effective to assign the spin and parity for neutron capture resonances.

  11. Impedance Measurement of an Antenna with Hydrogen Plasma Driven by 13.56 MHz-rf for J-PARC H{sup -} ion source

    SciTech Connect

    Ueno, A.; Namekawa, Y.; Ohkoshi, K.; Ikegami, K.; Oguri, H.

    2011-09-26

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup -} ion beam current of 50 mA and a life-time of 2000 hours, the development of a 13.56 MHz-rf-driven H{sup -} ion source was started by using an antenna developed at the Spallation Neutron Source (SNS). As the first step, the impedance of an antenna with hydrogen plasma, which is one of the most important parameters, was measured. For an rf-power of 0 kW, 1.25 kW or 7.45 kW, it was measured as j84.19+5.107 {Omega}, j80.22+11.82 {Omega} or j58.24+21.16 {Omega}, respectively. Its real-part had a rather large value and rather large rf-power dependence unexpectedly. By using the measured impedance, the circuit to produce rf-plasma in the plasma chamber on a -50 kV potential with a 13.56 MHz-rf-source on the ground potential was designed by the circuit simulation code LTSpice IV.

  12. Apprenez la Science en Francais?

    ERIC Educational Resources Information Center

    Edmonds, Juliet; Jacobs, Pippa

    2011-01-01

    The authors explain why integrating the teaching of science and French is not as ridiculous as it may at first sound. They describe how this innovative integrated approach works in a primary school in Oxfordshire. The project involves Content and Language Integrated Learning (CLIL). CLIL is a method whereby a curriculum subject is planned and…

  13. The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

    PubMed Central

    Sohi, Maninder K.; Veselkov, Dennis A.; Laponogov, Ivan; Pan, Xiao-Su; Fisher, L. Mark; Sanderson, Mark R.

    2008-01-01

    Background Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis. The emergence and increasing prevalence of resistance to penicillin and other antibiotics has led to interest in other anti-pneumonococcal drugs such as quinolones that target the enzymes DNA gyrase and topoisomerase IV. During crystallization and in the avenues to finding a method to determine phases for the structure of the ParC55 breakage-reunion domain of topoisomerase IV from Streptococcus pneumoniae, obstacles were faced at each stage of the process. These problems included: majority of the crystals being twinned, either non-diffracting or exhibiting a high mosaic spread. The crystals, which were grown under conditions that favoured diffraction, were difficult to flash-freeze without loosing diffraction. The initial structure solution by molecular replacement failed and the approach proved to be unviable due to the complexity of the problem. In the end the successful structure solution required an in-depth data analysis and a very detailed molecular replacement search. Methodology/Principal Findings Crystal anti-twinning agents have been tested and two different methods of flash freezing have been compared. The fragility of the crystals did not allow the usual method of transferring the crystals into the heavy atom solution. Consequently, it was necessary to co-crystallize in the presence of the heavy atom compound. The multiple isomorphous replacement approach was unsuccessful because the 7 cysteine mutants which were engineered could not be successfully derivatized. Ultimately, molecular replacement was used to solve the structure by sorting through a large number of solutions in space group P1 using CNS. Conclusions/Significance The main objective of this paper is to describe the obstacles which were faced and overcome in order to acquire data sets on such difficult crystals and determine phases

  14. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Ueno, A.; Koizumi, I.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2014-02-01

    The prototype rf-driven H- ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H- ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (TPE) of about 120 °C compared with the typically used TPE of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H- ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  15. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Koizumi, I.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2014-02-15

    The prototype rf-driven H{sup −} ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H{sup −} ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (T{sub PE}) of about 120 °C compared with the typically used T{sub PE} of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H{sup −} ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  16. High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.

    PubMed

    Leavis, Helen L; Willems, Rob J L; Top, Janetta; Bonten, Marc J M

    2006-03-01

    To substantiate a common genetic background of ciprofloxacin-resistant Enterococcus faecium, 32 ciprofloxacin-resistant (Cip(r)) and 31 ciprofloxacin-susceptible (Cip(s)) isolates from outbreaks, clinical infections, surveillances, and animals from 10 different countries were genotyped by multilocus sequence typing. Additionally, susceptibilities to ampicillin and vancomycin and the presence of esp were determined and the quinolone resistance-determining regions of parC, gyrA, parB, and gyrE were sequenced. High-level Cip(r) (MIC > or = 64 microg/ml) due to point mutations in the quinolone resistance-determining region was unique to a distinct hospital-adapted genetic complex in E. faecium, previously designated CC17. Low-level Cip(r) (MIC = 4 microg/ml) in non-CC17 strains is not attributable to point mutations in any subunit of the topoisomerase genes, and the mechanism of resistance remains unclear. Acquisition of mutations in parC and gyrA, leading to high-level Cip(r), is, in addition to ampicillin resistance and the presence of a putative pathogenicity island, another cumulative step in hospital adaptation of CC17.

  17. Les affaires "en francais" (Business "In French").

    ERIC Educational Resources Information Center

    Sanko, Helene N.

    1993-01-01

    A French brochure entitled "700 Current Words for Business" was developed to familiarize the business community with modern French business vocabulary and avoid intrusion of terminology from other languages. Some terms are neologisms. Translations from Latin, Japanese, and English illustrate the etymology and morphological patterns of…

  18. Le Francais Courant (Contemporary French), Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course has been developed basically within the limits of Units 4-6 of "A-LM French: Level 1", second edition. The primary objectives are to develop French vocabulary relative to the family, home, transportation, and foods by continuing to work with short dialogues based on everyday, teenage experiences. While reviewing previously studied…

  19. Le Francais Moderne, (Modern French) Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Performance objectives and broad goals for listening, speaking, reading, and writing skills in French instruction are presented in this text. Cultural awareness and student attitude are also considered. Vocabulary and structure of the course are presented through three situations: shopping, meeting a train, and making vacation plans. Short films…

  20. Le Francais quand meme (French Nonetheless).

    ERIC Educational Resources Information Center

    Delautier, Jean-Marie

    1983-01-01

    Political, attitudinal, and administrative problems of teaching compulsory foreign languages in Colombia are described and discussed from the point of view of a French teacher in a system characterized by confusion and lack of student interest. (MSE)

  1. Le Francais Courant, Part VI: Contemporary French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course, developed largely within the framework of units 13, 14, and 15 of the second edition of "A-LM French, Level 2," emphasizes development of basic audiolingual skills. Conversational topics permit the student to review his summer vacation. Principal elements of structure are expressions of quantity, pronouns--including those…

  2. Le Francais Courant, I (Contemporary French, I).

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Performance objectives focusing on the development of introductory skills in comprehension, speaking, reading, and writing are presented in this text of instructional materials. Lessons center about the use of short dialogues based on everyday, teenage experiences. Special emphasis is placed on vocabulary expansion, present tense of selected…

  3. The PARC Code: Theory and Usage

    DTIC Science & Technology

    1987-10-01

    1937E+01 VA’ RLES AT J ■= 25 81 A6DC-TR-87-24 Listing B-3. Continued K -» ESSURE TEMPERATURE MACH NUMBER TOTAL PRESS U-CDSINf V-COSINE * y 1 u...o o 00 VA’ "JLtS »tL.J’ Lisling B-6. Continued © oo K ■■ ESSURE TEMPERATURE MACH NUMBER TOTAL PRESS U-C05INF V-COSINE U-COSINE X 1 2 1 O

  4. Morphologie et syntaxe du francais (French Morphology and Syntax)

    ERIC Educational Resources Information Center

    Sourdot, Marc

    1977-01-01

    A study of the relationship of morphology and syntax to the communication process from the functionalist viewpoint. Topics considered are: morphological processes, that is the distinction between functional and contingent language facts; the degree of necessity of syntax; the difference between functionalism and traditional grammar. (Text is in…

  5. Roumanie: Le Francais d'abord (Romania: French First).

    ERIC Educational Resources Information Center

    Serren-Rosso, M. L.

    1993-01-01

    Eighty percent of the schools in Iasi, Moldova's capital city, teach French as a second language. The city's French Cultural Center is a focus for educational and cultural information and organization. The center helped upgrade the professional level of teaching following the demise of communism in Eastern Europe. (CNP)

  6. Vers un nouveau phonetisme francais (Toward a New French Phonetics)

    ERIC Educational Resources Information Center

    Monnot, Michel; Kite, Francoise

    1976-01-01

    Evolutionary changes in French pronunciation have necessitated changes in phonetic representation. The new articulatory phenomena involve modifications in syllabic structure and in consonant/vowel relationship. (Text is in French.) (DB)

  7. French: An Accommodating Language? = Le Francais: Langue D'Accueil?

    ERIC Educational Resources Information Center

    Wright, Sue, Ed.

    This bilingual book considers recent developments in French attitudes towards language purism, borrowing, and the incursion of English. The book begins with an essay by French sociolinguist Henriette Walter, and most of the following essays are direct responses to her ideas. All chapters are provided in French and English. Chapter titles include…

  8. Le francais par le theatre. (French through Theater).

    ERIC Educational Resources Information Center

    Agular, Claudio; And Others

    1983-01-01

    The techniques used in a course on "French through the theater" emphasize the dramatic rather than realistic, authentic expression rather than authentic language, and the use of instruction to launch students on their own personal course of learning. (MSE)

  9. Un cours avance de francais: Le francais tel qu'on le parle (An Advanced Course in French: Colloquial French)

    ERIC Educational Resources Information Center

    Creusot, Andre

    1971-01-01

    Second of three articles on an advanced French program sponsored by the Language Department of the State University of Mons, Belgium. Emphasis is on the phonology, lexicology, and syntax of spoken French. (DS)

  10. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Septieme annee (French: Yearly Curriculum. French as a Native Language: Seventh Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for seventh-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  11. Modeles de rendement langagier: Francais, 11e annee. Francais langue premiere (Models of Linguistic Production: French, 11th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for eleventh grade…

  12. Francais: Programme d'etudes du secondaire deuxieme cycle (10-12). Francais langue premiere (French: High School Curriculum [10-12]. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for high school French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  13. Modeles de rendement langagier: Francais, 12e annee. Francais langue premiere (Models of Linguistic Production: French, 12th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for twelfth grade…

  14. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Neuvieme annee (French: Yearly curriculum. French as a Native Language: Ninth year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for ninth-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  15. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Huitieme annee (French: Yearly Curriculum. French as a Native Language: Eighth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for eighth-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  16. Modeles de rendement langagier: Francais, 10e annee. Francais langue premiere (Models of Linguistic Production: French, 10th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for tenth grade students…

  17. Modeles de rendement langagier: Francais-7e annee. Francais langue premiere (Models of Linguistic Production--French as a Native Language: 7th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for seventh grade students…

  18. Une Planche de Salut pour le Francais: le Francais Quotidien et les Niveaux de Langue (A Last Resort for French: Everyday French and Language Levels)

    ERIC Educational Resources Information Center

    Jonas, Maurice

    1977-01-01

    Before asking how to teach French, one should ask what French to teach. It is suggested that everyday French, "la langue usuelle," should be the norm for American teachers and textbook writers and editers. Greater utilization of film scenarios and songs of good quality are among the means suggested. (Text is in French.) (AMH)

  19. Jouer au football... et apprendre le francais (Playing Football...and Learning French).

    ERIC Educational Resources Information Center

    Gutierrez, Alma Rosa Aguilar; Duarte, Delma Victoria Gonzalez

    1992-01-01

    Two teachers in Costa Rica have adopted a thematic approach to French second-language teaching that uses instructional materials about soccer from the French popular press and television, and related class activities, to motivate their students, for whom soccer is culturally important. (MSE)

  20. "L'unilinguisme" francais contre le changement sociolinguistique (French "Unilingualism" versus Sociolinguistic Change).

    ERIC Educational Resources Information Center

    Boyer, Henri

    2001-01-01

    This article describes the French unilingual, also seen as a sociolinguistic ideology, in its varieties, especially since the French Revolution: an ideology based on few representations that are both inner and outer linguistic. The article also discusses the attitude of the unilingual in the collective epilinguistic field of experiment. One…

  1. Chine: Les Chances du Francais (The Fortunes of the French Language in China).

    ERIC Educational Resources Information Center

    Shuning, Zhang

    1996-01-01

    Examines the current situation in China surrounding the teaching of French as a Foreign Language. After the decline of French teaching subsequent to the Cultural Revolution, the language returned to favor around 1970. Chinese students are infatuated with French; many study it as a first or second foreign language. Additionally, French literature…

  2. Vocabulaire de l'education: anglais-francais (Vocabulary of Education, English-French). Second Edition.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The glossary lists, in English, terms commonly used in education and their translations in French. The terminology applies to all levels of education (elementary, secondary, postsecondary) and to all areas of educational theory, instruction, and school administration. In some cases, additional explanatory or usage notes are provided in French. The…

  3. Australie: Pour quelques mots de francais (Australia: For a Little French).

    ERIC Educational Resources Information Center

    Monteil, Alain

    1991-01-01

    An Australian campaign to promote French second-language instruction uses the motto, "Big Bucks with a Little French." The campaign accompanies publication of the book "French in Australia: New Prospects," which seeks to reinforce and diversify the image of French and its use around the world, for business and pleasure. (MSE)

  4. Une lecon de francais avec des jeux electroniques (A French Lesson with Electronic Games).

    ERIC Educational Resources Information Center

    Malandain, Jean-Louis

    1996-01-01

    Electronic games are proposed as a means for encouraging students of French to learn and use the language while solving problems. A computerized card game and mine-removal game are offered as illustration of the language skills and vocabulary that can be developed and the appeal that such exercises can have for students. (MSE)

  5. L'Onomatopee dans la classe de francais (Onomatopoeia in the French Class).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1988-01-01

    Onomatopoeia is overlooked in many French grammar courses but plays a key role in everyday speech. Classification according to the feelings communicated stresses their importance. Students enjoy learning the sounds produced by animals in a second language and discovering the abundance of onomatopoeia in songs, commercials, comic books, and slang.…

  6. Japon: Le francais en sursis? (Japan: French in Stay of Execution?)

    ERIC Educational Resources Information Center

    Pecheur, Jacques

    1991-01-01

    In Japan, second-language instruction and specifically French instruction are at a crossroads. Despite appearances of normalcy, survival of university-level French instruction is threatened by greater current interest in Asian languages. In response, the French Embassy and Japanese Association of French Professors have established a policy to…

  7. L'Economie Francais. Units in Economics for French Classes. Intermediate Level.

    ERIC Educational Resources Information Center

    Jennings, Carol; And Others

    Four units on the French economy, designed for classroom use at the intermediate level, are related in their educational objectives: to shed light on French culture and strengthen second language skills. Each unit describes its specific objectives, materials, texts, instructional procedures, and student evaluation methods. Sample tests and…

  8. Uruguay: Le francais en quete d'image (Uruguay: French in Search of an Image).

    ERIC Educational Resources Information Center

    Francais dans le Monde, 1993

    1993-01-01

    The role of French language instruction in Uruguay is assessed. Drawing on results of recent surveys, it is observed that French suffers from a lackluster image, and from a lack of confidence among language teachers themselves. (MSE)

  9. Informatique et francais langue etrangere (Information Science and French as a Foreign Language).

    ERIC Educational Resources Information Center

    Abry, Dominique; Scholl, Maryse

    1984-01-01

    An interdisciplinary experiment to develop materials for computer-assisted French instruction at the University of Grenoble is described and the process of translating objectives and strategies into exercises relying on student-machine interaction is chronicled. Three approaches were used: student response using stated rules, recognition…

  10. L'Enseignement du Francais au Moyen de L'Action (Teaching French through Action).

    ERIC Educational Resources Information Center

    Segal, Bertha

    A teaching guide containing 102 elementary to intermediate level French lessons is presented. The lessons are based on the Total Physical Response technique of second language instruction. They follow the stages of first language acquisition: listening, speaking, and reading. Each of the ten units contains a list of vocabulary words, individual…

  11. "Une Certaine idee du francais": The Dilemma for French Language Policy in the 21st Century.

    ERIC Educational Resources Information Center

    Shelly, Sharon L.

    1999-01-01

    The global French-speaking community recognizes the need to better coordinate its efforts to assert the vitality of French in a world increasingly dominated by English. In pursuing this goal, the Francophone world has developed an identity crisis. Defenders of French face difficult questions about the relationship between language and culture and…

  12. Francais: Langue de specialite: Gearing Commercial French for the World of 1992.

    ERIC Educational Resources Information Center

    Finel-Honigman, Irene

    In the area of business-related language training, the United States lags behind Europe, where graduate business schools require at least one foreign language with business proficiency for graduation. In most United States institutions, the long-standing policy of departmentalization and a perceived dichotomy between the humanities and traditional…

  13. Le Francais des Professions Scientifiques et Techniques (French for the Scientific and Technical Professions).

    ERIC Educational Resources Information Center

    Muller, Brigitte

    Two sequential courses in scientific and technical French developed as a supplement to third- and fourth-year college French, in response to expressed student and industry demand, had as their objectives to develop a general familiarity with products of the large French industrial companies and their United States affiliates and to develop means…

  14. Le francais fonde sur la competence, Novice (Competency Based French, Novice).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. The guide includes 21 topical lessons at the introductory level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues. Lesson topics include: greetings; introducing…

  15. Technoscientific French Teaching Guide = Guide pour l'enseignement du Francais technoscientifique.

    ERIC Educational Resources Information Center

    Muller, Brigitte D.

    This course guide aids university professors in doing research to develop a course in scientific and technical French. The course is intended to aid students in developing communicative skills in French in the context of science and technology. The course introduces students to the culture of France as well as to its industrial and technological…

  16. Le Francais parle. Etudes sociolinguistiques (Spoken French. Sociolinguistic Studies). Current Inquiry into Languages and Linguistics 30.

    ERIC Educational Resources Information Center

    Thibault, Pierrette

    This volume contains twelve articles dealing with the French language as spoken in Quebec. The following topics are addressed: (1) language change and variation; (2) coordinating expressions in the French spoken in Montreal; (3) expressive language as source of language change; (4) the role of correction in conversation; (5) social change and…

  17. Aspirations langagieres: Negociation et apprentissage du francais (Language Aspirations: Negotiation and Learning French).

    ERIC Educational Resources Information Center

    Lepetit, Daniel; Cichocki, Wladyslaw

    1990-01-01

    A survey of 130 beginning French students at the University of Windsor (Canada) focused on their second language aspirations, expectations, and anticipated needs. Interpersonal relations appear to be the primary motivator, with travel and instrumental motivation secondary. (20 references) (Author/MSE)

  18. Alors...euh...on parle francais? (So...um...Shall We Speak French?)

    ERIC Educational Resources Information Center

    Frommer, Judith G.; Ishikawa, Wayne

    1980-01-01

    Describes a one-semester conversational course taught at Harvard University designed to teach basic oral communication skills in French with the main emphasis on teaching students to pause while speaking. (AM)

  19. NORME PEDAGOGIQUE--LES STRUCTURES INTERROGATIVES DU FRANCAIS (PEDAGOGICAL NORM--THE INTERROGATIVE STRUCTURES OF FRENCH).

    ERIC Educational Resources Information Center

    VALDMAN, ALBERT

    THIS PAPER DISCUSSES THE SELECTION OF A PEDAGOGICAL NORM FOR FRENCH INTERROGATIVE STRUCTURES. SINCE THIS AREA OF FRENCH GRAMMAR IS PARTICULARLY POLYMORPHOUS, OBJECTIVE CRITERIA ARE SET UP TO MAKE THE SELECTION--FREQUENCY, COMPLEXITY, AND EXTENSIVITY. BECAUSE "EST-CE QUE" CAN BE APPLIED WITHOUT EXCEPTION TO ALL TYPES OF KERNEL SENTENCES, IT WAS…

  20. Enseigner quel francais du tourisme (Which French to Teach for Tourism).

    ERIC Educational Resources Information Center

    Larsson, Bjorn

    1992-01-01

    Development of a course in French for tourism and the hotel industry in Sweden is chronicled, focusing on the process of functional analysis used to determine appropriate language content. A general functional outline of touristic French and an outline of language functions specific to a restaurant situation are presented. (MSE)

  1. On Parle Francais Ici: The People of the St. John Valley Have a Tremendous Advantage.

    ERIC Educational Resources Information Center

    Banville, Beurmond J.

    1995-01-01

    A change in philosophy concerning the maintenance of native languages has led to local efforts to revive the French language in the St. John Valley (Maine), including the formation of a community organization and implementation of language programs in which children in all grades receive daily instruction in French. (LP)

  2. Bibliographie pour enseigner le francais des affaires (Bibliography for Business French Instruction).

    ERIC Educational Resources Information Center

    Dewey, S. Pascale

    This bibliography contains a list of various publications (books, journals, dictionaries, newspapers, magazines) as well as videos, CD-ROMs, Web sites, and the addresses of several French chambers of commerce that would be useful for any English speakers needing to live, do business, or otherwise spend time in France. References are in French or…

  3. Parametres de delimitation des collocations du francais courant (Parameters for Delimiting Collocations in Contemporary French).

    ERIC Educational Resources Information Center

    Bosse-Andrieu, J.; Mareschal, G.

    1998-01-01

    Discusses the definition of collocation, demonstrates that associative word combinations do form a continuum, and proposes some parameters to help delimit the scope of collocations in everyday contemporary French. (Author/VWL)

  4. Didactique du francais langue seconde, dramatisation, et theatre (French Second Language Teaching, Dramatization, and Theater).

    ERIC Educational Resources Information Center

    Fancy, Alex

    1991-01-01

    Use of dramatics in French second language education is advocated with theoretical and practical arguments, and a four-stage approach to language acquisition through theater is proposed. The approach is based on activities of a bilingual theater troupe that offers Mount Allison University (New Brunswick) students an opportunity to participate in…

  5. PARCS: A Safety Net Community-Based Fitness Center for Low-Income Adults

    PubMed Central

    Keith, NiCole; de Groot, Mary; Mi, Deming; Alexander, Kisha; Kaiser, Stephanie

    2015-01-01

    Background Physical activity (PA) and fitness are critical to maintaining health and avoiding chronic disease. Limited access to fitness facilities in low-income urban areas has been identified as a contributor to low PA participation and poor fitness. Objectives This research describes community-based fitness centers established for adults living in low-income, urban communities and characterizes a sample of its members. Methods The community identified a need for physical fitness opportunities to improve residents’ health. Three community high schools were host sites. Resources were combined to renovate and staff facilities, acquire equipment, and refer patients to exercise. The study sample included 170 members ≥ age 18yr who completed demographic, exercise self-efficacy, and quality of life surveys and a fitness evaluation. Neighborhood-level U.S. Census data were obtained for comparison. Results The community-based fitness centers resulted from university, public school, and hospital partnerships offering safe, accessible, and affordable exercise opportunities. The study sample mean BMI was 35 ± 7.6 (Class II obesity), mean age was 50yr ± 12.5, 66% were black, 72% were female, 66% completed some college or greater, and 71% had an annual household income < $25K and supported 2.2 dependents. Participants had moderate confidence for exercise participation and low fitness levels. When compared to census data, participants were representative of their communities. Conclusion This observational study reveals a need for affordable fitness centers for low-income adults. We demonstrate a model where communities and organizations strategically leverage resources to address disparities in physical fitness and health. PMID:27346764

  6. Bunch Shape Measurement of 181 MeV Beam in J-PARC Linac

    NASA Astrophysics Data System (ADS)

    Miura, Akihiko; Feschenko, Alexander V.; Mirzojan, Alexander N.; Miyao, Tomoaki; Ouchi, Nobuo; Maruta, Tomofumi; Liu, Yong; Oguri, Hidetomo; Ikegami, Masanori; Hasegawa, Kazuo

    In the Japan Proton Accelerator Research Complex linac, an energy upgrade project was started in 2009 using annular-ring coupled structure (ACS) linac cavities. We decided to use bunch shape monitors (BSM) for monitoring longitudinal beam width measurement to achieve longitudinal matching using two bunchers located upstream of the ACS cavities, where the radio frequency jumps from 324 to 972 MHz. Three BSMs were fabricated and installed in the original beam line. The BSMs were commissioned with the beam and their operability was demonstrated. In this study, we introduce the mechanism of the BSMs, its operability, measurement results with the 181 MeV beam, and consistency check with the respective cavity amplitude. Furthermore, we describe the operational vacuum conditions and outline the improvements to the BSMs' vacuum system.

  7. Planification de la maintenance d'un parc de turbines-alternateurs par programmation mathematique

    NASA Astrophysics Data System (ADS)

    Aoudjit, Hakim

    A growing number of Hydro-Quebec's hydro generators are at the end of their useful life and maintenance managers fear to face a number of overhauls exceeding what can be handled. Maintenance crews and budgets are limited and these withdrawals may take up to a full year and mobilize significant resources in addition to the loss of electricity production. In addition, increased export sales forecasts and severe production patterns are expected to speed up wear that can lead to halting many units at the same time. Currently, expert judgment is at the heart of withdrawals which rely primarily on periodic inspections and in-situ measurements and the results are sent to the maintenance planning team who coordinate all the withdrawals decisions. The degradations phenomena taking place is random in nature and the prediction capability of wear using only inspections is limited to short-term at best. A long term planning of major overhauls is sought by managers for the sake of justifying and rationalizing budgets and resources. The maintenance managers are able to provide a huge amount of data. Among them, is the hourly production of each unit for several years, the repairs history on each part of a unit as well as major withdrawals since the 1950's. In this research, we tackle the problem of long term maintenance planning for a fleet of 90 hydro generators at Hydro-Quebec over a 50 years planning horizon period. We lay a scientific and rational framework to support withdrawals decisions by using part of the available data and maintenance history while fulfilling a set of technical and economic constraints. We propose a planning approach based on a constrained optimization framework. We begin by decomposing and sorting hydro generator components to highlight the most influential parts. A failure rate model is developed to take into account the technical characteristics and unit utilization. Then, replacement and repair policies are evaluated for each of the components then strategies are derived for the whole unit. Traditional univariate policies such as the age replacement policy and the minimal repair policy are calculated. These policies are extended to build alternative bivariate maintenance policy as well as a repair strategy where the state of a component after a repair is rejuvenated by a constant coefficient. These templates form the basis for the calculation of objective function for the scheduling problem. On one hand, this issue is treated as a nonlinear problem where the objective is to minimize the average total maintenance cost per unit of time on an infinite horizon for the fleet with technical and economic constraints. A formulation is also proposed in the case of a finite time horizon. In the event of electricity production variation, and given that the usage profile is known, the influence of production scenarios is reflected on the unit's components through their failure rate. In this context, prognoses on possible resources problems are made by studying the characteristics of the generated plans. On the second hand, the withdrawals are now subjected to two decision criteria. In addition to minimizing the average total maintenance cost per unit of time on an infinite time horizon, the best achievable reliability of remaining turbo generators is sought. This problem is treated as a biobjective nonlinear optimization problem. Finally a series of problems describing multiple contexts are solved for planning renovations of 90 turbo generators units considering 3 major components in each unit and 2 types of maintenance policies for each component.

  8. Event Analysis in Nuclear Emulsion for the E07 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Soe, Myint K.; Endo, Yoko; Hoshino, Kaoru; Ito, Hiroki; Itonaga, Kazunori; Kobayashi, Hidetaka; Tint, Khin T.; Kinbara, Shinji; Mishina, Akihiro; Yoshida, Junya; Nakazawa, Kazuma

    Hammer track events in nuclear emulsion were analyzed to measure the excitation energy of 8Be* (2+) nucleus. The kinetic energies of two alpha particles of hammer track events were obtained from their ranges with use of range-energy relation. The range-energy relation was calibrated by measuring the alpha particle tracks emitted from 212Po of Thorium decay series in the emulsion. From this calibration, we obtained density and shrinkage factor of the emulsion. The excitation energy and width of 8Be* (2+) nucleus were measured to be 3.39 ± 0.24 MeV and Γ = 1.22 ± 0.60 MeV respectively.

  9. PARC Analysis of the NASA/GE 2D NRA Mixer/Ejector Nozzle

    NASA Technical Reports Server (NTRS)

    DeBonis, J. R.

    1999-01-01

    Interest in developing a new generation supersonic transport has increased in the past several years. Current projections indicate this aircraft would cruise at approximately Mach 2.4, have a range of 5000 nautical miles and carry at least 250 passengers. A large market for such an aircraft will exist in the next century due to a predicted doubling of the demand for long range air transportation by the end of the century and the growing influence of the Pacific Rim nations. Such a proposed aircraft could more than halve the flying time from Los Angeles to Tokyo. However, before a new economically feasible supersonic transport can be built, many key technologies must be developed. Among these technologies is noise suppression. Propulsion systems for a supersonic transport using current technology would exceed acceptable noise levels. All new aircraft must satisfy FAR 36 Stage III noise regulations. The largest area of concern is the noise generated during takeoff. A concerted effort under NASA's High Speed Research (HSR) program has begun to address the problem of noise suppression. One of the most promising concepts being studied in the area of noise suppression is the mixer/ejector nozzle. This study analyzes a typical noise suppressing mixer ejector nozzle at take off conditions, using a Full Navier-Stokes (FNS) computational fluid dynamics (CFD) code.

  10. Pulsed ultra-cold neutron production using a Doppler shifter at J-PARC

    NASA Astrophysics Data System (ADS)

    Imajo, S.; Mishima, K.; Kitaguchi, M.; Iwashia, Y.; Yamada, N. L.; Hino, M.; Oda, T.; Ino, T.; Shimizu, H. M.; Yamashita, S.; Katayama, R.

    2016-01-01

    We have constructed a Doppler-shifter-type pulsed ultra-cold neutron (UCN) source at the Materials and Life Science Experiment Facility of the Japan Proton Accelerator Research Complex. Very cold neutrons (VCNs) with 136 m s^{-1} velocity in a neutron beam supplied by a pulsed neutron source are decelerated by reflection on an m=10 wide-band multilayer mirror, yielding pulsed UCNs. The mirror is fixed to the tip of a 2000 rpm rotating arm moving with 68 m s^{-1} velocity in the same direction as the VCNs. The repetition frequency of the pulsed UCNs is 8.33 Hz and the time width of the pulse at production is 4.4 ms. In order to increase the UCN flux, a supermirror guide, wide-band monochromatic mirrors, focus guides, and a UCN extraction guide have been newly installed or improved. The 1 MW-equivalent count rate of the output neutrons with longitudinal wavelengths longer than 58 nm is 1.6 × 102 cps, while that of the true UCNs is 80 cps. The spatial density at production is 1.4 UCN cm^{-3}. This new UCN source enables us to research and develop apparatuses necessary for the investigation of the neutron electric dipole moment.

  11. Status of the RF-driven H⁻ ion source for J-PARC linac.

    PubMed

    Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Ueno, A; Shibata, T

    2016-02-01

    For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than once a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then.

  12. Rebalancing risk management--part 1: The Process for Active Risk Control (PARC).

    PubMed

    Card, Alan J; Ward, James R; Clarkson, P John

    2014-01-01

    Risk assessment, by itself, does nothing to reduce risk or improve safety. It can only change outcomes by informing the design and management of effective risk control interventions. But current practice in healthcare risk management suffers from an almost complete lack of support for risk control. This first installment of a 2-part series on rebalancing risk management describes a new framework to guide risk control practice: The Process for Active Risk Control.

  13. Quels sont les problemes ethiques souleves par l’augmentation des capacites cognitives dans le cadre de la defense : cadre legal francais, position ethique du service de sante des armees francais

    DTIC Science & Technology

    2009-10-01

    ethical principles for conducting researches on humans as animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some...animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some modifications were added in 2004 in accordance with European texts...Royaume-Uni, le Nuffield Council on Bioethics , organisme privé qui a pour mission d’examiner les questions bioéthiques pour le gouvernement, a publié

  14. Cadre conceptuel des programmes de francais a l'elementaire: lignes directrices (Conceptual Framework for Elementary School French Programs: Axes).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The conceptual framework within which Alberta's elementary school French immersion programs are designed is presented. The first of three main sections outlines the evolution of the concept of language and some second language instructional approaches, including the structural, formalist, functional, and communicative approaches. It also discusses…

  15. Francais et langue maternelle en Yougoslavie: convergences et contacts. (French and Native Language in Yugoslavia: Convergences and Contacts.)

    ERIC Educational Resources Information Center

    Vrhovac, Yvonne

    1983-01-01

    Elements of recent national educational reform in Yugoslavia that contribute to the integration of native and foreign language instruction are outlined, touching on instructional techniques for phonology, communicative competence, written and oral expression and comprehension, vocabulary acquisition, and grammar. (MSE)

  16. Vers un renouveau du "mirage americain" dans les lettres francais (Toward a Renewal of the "American Mirage" in French Literature)

    ERIC Educational Resources Information Center

    Huvos, Kornel

    1973-01-01

    Social and political commentary on the alternating images of America projected in French writing through the years; revised version of a paper presented at the 25th Annual Kentucky Foreign Language Conference, Lexington, Kentucky, April 28, 1972. (RL)

  17. Geographie du francais et de la francite en Louisiane (The Geography of the French Language and Character in Louisiana).

    ERIC Educational Resources Information Center

    Breton, Roland J.-L.

    This study, based on the 1970 U. S. census, concerns Francophones and French influences that are evident, particularly in Louisiana. Four aspects of the question are treated: (1) linguistic minorities in the U. S., especially those of Hispanic and German origin; (2) the history of Franco-Americans; (3) the present state of French in Louisana; and…

  18. Tutoiement et Vouvoiement chez les Lyceens Francais (French Pupils' Use of the Personal Pronouns "Tu" and "Vous")

    ERIC Educational Resources Information Center

    Bustin-Lekeu, Francine

    1973-01-01

    Surveys conducted among secondary school students in Toulon, France in choice of personal pronouns indicate more prevalent use of tu''. Students consider widespread use of tu'' to be more democratic and thought employment of vous'' on certain occasions is a hypocritical and bourgeois habit. (DS)

  19. Dictionnaire contextuel anglais-francais de l'energie solaire (Contextual English-French Dictionary on Solar Energy).

    ERIC Educational Resources Information Center

    Serre, Robert

    This English-French dictionary on solar energy is intended for translators and purports to contain all the elements necessary for doing quality translations. Each entry contains the following elements: (1) the basic English word with its synonyms and equivalents; (2) the definition in English and reference to its source; and (3) sentences or…

  20. Vers Une Analyse systematique de l'interrogation en francais (Toward a Systematic Analysis of the French Interrogative).

    ERIC Educational Resources Information Center

    Azoulay-Vicente, Avigail

    1988-01-01

    A systematic analysis of the French interrogative focuses on the distinction between the syntactic processes (identification of question words, interrogative phrase preposing, and rules of question formation) and phonological processes (intonation patterns) that characterize questions in French. (Author/MSE)

  1. Theatre et enseignement du francais, langue etrangere (Theater and the Teaching of French as a Foreign Language).

    ERIC Educational Resources Information Center

    Maldaner, Aurea

    1980-01-01

    Discusses drama in foreign language instruction, especially as a means of improving oral expression. Two basic approaches are outlined and three techniques that have been used successfully with various age groups are described. (AMH)

  2. Pour Adolescent et Adulte, Francais Langue Etrangere, Niveau 1 (French as a Foreign Language, Level 1, for Adolescents and Adults)

    ERIC Educational Resources Information Center

    Gibert, Pierre

    1975-01-01

    This annotated bibliography lists dictionaries and reading materials including stories and legends, biographies, works relating to cinema, theatre and French civilization, magazines, and educational activities and games for introductory instruction of French as a foreign language to adults and adolescents. (Text is in French.) (CLK)

  3. Techniques de Theatre Integrees a l'Enseignement du Francais 1989 = Theatre Techniques Integrated into the Teaching of French, 1989.

    ERIC Educational Resources Information Center

    Parent, Roger

    This curriculum guide presents a methodology for teaching language and literature through role-playing in the classroom and demonstrates to teachers the link that exists between effective communication and the techniques used to achieve it. The new French program views language as an instrument of communication, a concept that implies that…

  4. Conceptual design of a polarized 3He neutron spin filter for polarized neutron spectrometer POLANO at J-PARC

    NASA Astrophysics Data System (ADS)

    Ino, T.; Ohoyama, K.; Yokoo, T.; Itoh, S.; Ohkawara, M.; Kira, H.; Hayashida, H.; Sakai, K.; Hiroi, K.; Oku, T.; Kakurai, K.; Chang, L. J.

    2016-04-01

    A 3He neutron spin filter (NSF) has been designed for a new polarized neutron chopper spectrometer called the Polarization Analysis Neutron Spectrometer with Correlation Method (POLANO) at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Research Complex. It is designed to fit in a limited space on the spectrometer as an initial neutron beam polarizer and is polarized in situ by spin exchange optical pumping. This will be the first generation 3He NSF on POLANO, and a polarized neutron beam up to 100 meV with a diameter of 50 mm will be available for research on magnetism, hydrogen materials, and strongly correlated electron systems.

  5. Status of the RF-driven H{sup −} ion source for J-PARC linac

    SciTech Connect

    Oguri, H. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Ueno, A.; Shibata, T.

    2016-02-15

    For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than once a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then.

  6. Problemes d'analyse du discours. Essai de description du discours francais sur la Chine (Problems in Discourse Analysis. An Attempt to Describe French Discourse on China).

    ERIC Educational Resources Information Center

    Marindin, Jean-Marie

    1979-01-01

    The following topics are developed: (1) the problematic aspect of the analysis of French discourse, an introduction to methods, theories and applications; (2) the proposals of M. Pecheux; (3) precisions to render operative definitions derived in the proposals; (4) the Macciocchi manner of speaking; and (5) the Peyrefitte manner of speaking. (AMH)

  7. La maternelle--francais langue premiere: Manuel a l'intention des parents (Pre-School--French as a Native Language: Parents' Manual).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This manual, intended for the parents of new pre-school students, presents information on the organization and curriculum of Alberta's French-language pre-school programs for native speakers of French. Written from the point of view of a fictional pre-school teacher, the manual responds to parents' frequently asked questions on topics such as…

  8. Modeles de rendement langagier--Francais langue premiere: 8e annee (Models of Linguistic Production--French as a Native Language: 8th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for eighth grade students…

  9. Modeles de rendement langagier--Francais langue premiere: 9e annee (Models of Linguistic Production--French as a Native Language: 9th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for ninth grade students…

  10. Cadre conceptuel des programmes de francais au secondaire: lignes directrices. Immersion (Conceptual Framework for French Programs at the Secondary Level: Guidelines. Immersion).

    ERIC Educational Resources Information Center

    Bourque, Francine; And Others

    Conceptual guidelines for the design of new secondary school French second language programs are outlined, in response to the need for an instructional model to accommodate Alberta's increasing anglophone enrollment in French immersion programs. The first section chronicles the evolution of the concept of language and second language instructional…

  11. Synthese et methodologie des moyens de correction phonetique du "R" francais enseigne aux anglophones (Methods of Correcting the Pronunciation of the French "R" for English Speakers).

    ERIC Educational Resources Information Center

    Lebel, Jean-Guy

    The present work begins with a phonetic description of the acceptable French /R/ and descriptions of several allophones of English /R/ which must be avoided while learning the French. Various theories are discussed concerning the relationship between the position of the /R/ in an utterance and the difficulty students have in pronouncing it…

  12. Images de la societe dans le cinema francais des dix dernieres annees (Images of Society in French Film in the Last Ten Years).

    ERIC Educational Resources Information Center

    Esteve, Michel

    1980-01-01

    It is proposed that film has become a mirror of French society and of social change in France since 1968. It reflects changes in life-style, evolution of morals, fluctuations in fashion, and changes in urban and rural landscapes. However, it rarely questions society seriously. (MSE)

  13. Intonation et syntaxe chez l'enfant francais a partir de dix-huit mois (Intonation and Syntax in the French Child from the Age of 18 months)

    ERIC Educational Resources Information Center

    Leroy, Christine

    1975-01-01

    This article reports on a study to determine the role of intonation in language acquisition. Related studies are mentioned. Research methods for the study are outlined and two case studies are reviewed. Conclusions show that adult-child interaction influences not only the child's use of intonation but also his acquisition of syntax. (Text is in…

  14. Francais langue seconde: Les apprenants face au discours didactique oral. (French as a Second Language: How Learners Deal with Didactic Oral Discourse).

    ERIC Educational Resources Information Center

    Cabut, Helene

    As part of a course in French for foreign post-graduate engineering students, recordings of a series of lectures in information science were used to highlight some of the problems involved in the comprehension of spoken scientific discourse. In order to observe whether repetitions within oral discourse were perceived as such by non-French speaking…

  15. Les examens de francais dans le second cycle en Grande-Bretagne (French Examinations in the Second Cycle in Great Britain)

    ERIC Educational Resources Information Center

    Nott, David

    1978-01-01

    A description of the status of foreign language instruction and testing in the context of the changing state of education. The content of Second Cycle French programs, a critique of French examinations and some samples of tests which point to change are discussed. (Text is in French.) (AMH)

  16. "-age" dans le systeme suffixal du francais quebecois ("-age" in the Suffix System of Quebec French). Montreal Working Papers in Linguistics, Vol. 4.

    ERIC Educational Resources Information Center

    Pupier, Paul; And Others

    This study relates the suffix "-age" to "-able,""-eux,""-ment,""-Xtion," and "-ure" in Quebec French. Morphologically, some "-age" suffixals which can be denominal in Quebec French can only be deverbal in European French. Semantically, "-age" deverbals are subdivided…

  17. La place de la negation syntaxique en francais (The Place of Syntactic Negation in French). Montreal Working Papers in Linguistics, Vol. 2.

    ERIC Educational Resources Information Center

    Paradis, Michel

    This paper is a syntactic analysis of standard French negation. The following expressions are described in detail: (1)ne...pas(point), (2)nullement (aucunement), (3)plus, (4)jamais, (5)pas encore, (6)guere, (7)rien, (8)personne, (9)aucun(e), (10)nul(le), (11)ni...ni..., (12)nulle part, (13)que, (14)pas un(e), (15)nul. The negative expressions are…

  18. La francophonie dans les manuels de francais langue seconde: apports et limites (Francophony in French Second Language Textbooks: Contributions and Limitations).

    ERIC Educational Resources Information Center

    Fleig-Hamm, Christiane

    1998-01-01

    This study examined representation of francophone regions other than France in readings and activities in French second-language textbooks published since 1995. The model of representation used shows the richness and variety of the cultures, contains no inaccurate information, and gives a realistic portrayal devoid of colonialistic and…

  19. Vers une autonomie croissante de l'apprenant du francais langue etrangere (Toward an Increasing Autonomy of the French as a Foreign Language Learner)?

    ERIC Educational Resources Information Center

    Hoeflaak, Arie; Verloop, Nico

    2000-01-01

    Investigates characteristics of spoken French texts. Experience teaching French as a foreign language has revealed that some university students, even at a relatively advanced level, have difficulty understanding the news on Radio France International. Suggests that three characteristics of the spoken news program that may cause students…

  20. Des stereotypes de la France et des Francais chez des etudiants mexicains (Some Stereotypes of France and the French Held by Mexican Students).

    ERIC Educational Resources Information Center

    Pugibet, Veronica

    1983-01-01

    The origins and functions of stereotypes are discussed, a classroom study of Mexican students' perceptions of the French and French culture based on their responses to French advertising and cartoons is reported, and implications for instruction and teacher behavior to change existing stereotypes are outlined. (MSE)

  1. A propos de quelques experiences de francais fonctionnel en milieu hispanaphone (A Commentary on Experiments in Functional French in a Spanish-Speaking Milieu)

    ERIC Educational Resources Information Center

    Baltzer, Francois

    1978-01-01

    A discussion of the adaptation of audiovisual methods to respond to various specific needs in Mexico City. Some of the topics discussed are: meeting needs of people involved in special fields, particularly science, technology and economics; and the use of television for functional French instruction. (AMH)

  2. "Peau d'Ane" videodisque interactif de francais, langue etrangere ("Donkey's Hide," an Interactive Videodisc in French as a Second Language).

    ERIC Educational Resources Information Center

    Garrigues, Mylene

    1985-01-01

    The characteristics of videodisc technology are outlined, and a project undertaken to create an interactive videodisc for French language instruction is described, including the efforts to eliminate physical barriers between the computer and the user, pedagogical strategy and material, programing technicalities, and other details of production.…

  3. L'Alternance entre les auxiliaires "avoir" et "etre" en francais parle a Montreal (Alternation between the Auxiliaries "Avoir" and "Etre" in Spoken French in Montreal)

    ERIC Educational Resources Information Center

    Sankoff, Gillian; Thibault, Pierrette

    1977-01-01

    A study of the spoken French of 120 residents of Montreal. The researchers were interested in the linguistic and social factors influencing the use of "avoir" and "etre." Results show that this usage corresponds to a tendancy to regularize conjugations. (Text is in French.) (AMH)

  4. Recherche empirique sur l'effet de la musique dans l'enseignement suggestopedique du francais (Empirical Research on the Effect of Music in Suggestopedic French Instruction).

    ERIC Educational Resources Information Center

    Schiffler, Ludger

    1986-01-01

    A study of the effectiveness of music techniques in French second-language instruction using the suggestopedic approach is reported. The study attempts to control for variations commonly found in experimental conditions. (MSE)

  5. L'interjection: son role et son impact dans une classe de francais (Interjection: Its Role and Impact in a French Class).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1983-01-01

    It is suggested that students of French should be exposed to the richness of a living language by introducing them to all possible outputs and underlining the importance of the interjection in oral discourse. A number of common interjections and usage situations are outlined, and some teaching methods are discussed. (MSE)

  6. Gestion de stockage d'energie thermique d'un parc de chauffe-eaux par une commande a champ moyen

    NASA Astrophysics Data System (ADS)

    Bourdel, Benoit

    In today's energy transition, smart grids and electrical load control are very active research fields. This master's thesis is an offshoot of the SmartDesc project which aims at using energy storage capability of electric household appliances, such as water heaters and electric heaters to mitigate the fluctuations of system loads and renewable generation. The smartDESC project aims at demonstrating that the mean field game theory (MFG), as new mathematical theory, can be used to convert and control water heaters (and possibly space heater) into smart thermal capacities. Thus, a set of "modules" has been developed. These modules are used to generate the optimal control and locally interpret it, to simulate the water-heater thermophysics or water draw event, or to virtualize a telecommunication mesh network. The different aspects of the project have been first studied and developed separately. During the course of this master's research, the modules have been integrated, tested, interfaced and tuned in a common simulator. This simulator is designed to make complete electrical network simulations with a multi-scale approach (from individual water heater to global electric load and production). Firstly, the modules are precisely described theoretically and practically. Then, different types of control are applied to an uniform population of houses fitted with water heaters and controllers. The results of these controls are analysed and compared in order to understand their strengths and weaknesses. Finally, a study was conducted to analyse the resilience of a mean field control. This report demonstrates that mean field game theory in coordination with a system level aggregate model based optimization program, is able to effectively control a large population of water heaters to smooth the overall electrical load. This control offers good resilience to unforeseen circumstances that can disrupt the network. It is also demonstrated that a mean field control is able to absorb fluctuations due to wind power production. Thus, by reducing the variability of the residential sector's electrical charge, the mean field control plays a role in increasing power system stability in the face of high levels of renewable energy penetration. The next stage of smartDESC project is now to set up an intelligent electric water heater prototype. This prototype, in progress since January 2016 at Ecole Polytechnique in Montreal, is aimed at proving concretely the theories developed in the project.

  7. Investigation of the Long-Term Performance of the 324 MHz Klystrons for Achieving the Efficient Operation of the Linac at J-PARC

    NASA Astrophysics Data System (ADS)

    Hori, T.; Shinozaki, S.; Chishiro, E.; Sato, F.; Kawamura, M.; Futatsukawa, K.; Fukui, Y.; Oguri, H.

    As a part of the researches of the reliability and life time of klystrons, the cathode performance test of 324 MHz klystrons operated for 32000 hours on line has been performed at the klystron test stand. The experimental results coincide approximately with the data both reported in the literature for the cathode performance and the one obtained from the data base of RF data acquisition system. In this test, two parameters such as klystron beam perveance and knee-point were used to investigate the emission performance. It turned out that klystron beam perveance is most suitable parameter for understanding the klystron performance under operating condition on line.

  8. Parks and People. A European Conference for Naturparke Parcs Naturels/National Parks (U.K.) and Equivalent Reserves (Losehill Hall, Castleton, England, September 25-29, 1978).

    ERIC Educational Resources Information Center

    Youel, Alex J.

    Presented are the proceedings of the European Conference for National Parks and Equivalent Reserves held at the Peak National Park Study Centre, Castleton, England in 1978. Thirty-nine representatives from 10 countries focused on the relationship between the parks and the people connected with them (the local people, the visitors, and the park…

  9. Physical activity and the rejuvenation of Connswater (PARC study): protocol for a natural experiment investigating the impact of urban regeneration on public health

    PubMed Central

    2013-01-01

    Background There is a dearth of evidence regarding the impact of urban regeneration projects on public health, particularly the nature and degree to which urban regeneration impacts upon health-related behaviour change. Natural experiment methodology enables comprehensive large-scale evaluations of such interventions. The Connswater Community Greenway in Belfast is a major urban regeneration project involving the development of a 9 km linear park, including the provision of new cycle paths and walkways. In addition to the environmental improvements, this complex intervention involves a number of programmes to promote physical activity in the regenerated area. The project affords a unique opportunity to investigate the public health impact of urban regeneration. Methods/Design The evaluation framework was informed by the socio-ecological model and guided by the RE-AIM Framework. Key components include: (1) a quasi-experimental before-and-after survey of the Greenway population (repeated cross-sectional design), in tandem with data from a parallel Northern Ireland-wide survey for comparison; (2) an assessment of changes in the local built environment and of walkability using geographic information systems; (3) semi-structured interviews with a purposive sample of survey respondents, and a range of community stakeholders, before and after the regeneration project; and (4) a cost-effectiveness analysis. The primary outcome is change in proportion of individuals identified as being regularly physically active, according to the current UK recommendations. The RE-AIM Framework will be used to make an overall assessment of the impact of the Greenway on the physical activity behaviour of local residents. Discussion The Connswater Community Greenway provides a significant opportunity to achieve long-term, population level behaviour change. We argue that urban regeneration may be conceptualised meaningfully as a complex intervention comprising multiple components with the potential, individually and interactively, to affect the behaviour of a diverse population. The development and implementation of our comprehensive evaluation framework reflects this complexity and illuminates an approach to the empirical, rigorous evaluation of urban regeneration. More specifically, this study will add to the much needed evidence-base about the impact of urban regeneration on public health as well as having important implications for the development of natural experiment methodology. PMID:24103381

  10. Le Developpement du francais oral soutenu par l'analyse du langage, 3e-6e annee (The Development of Sustained Oral French through Language Analysis, Grades 3-6). Serie: Le Francais a l'ecole primaire. Documentation pedagogique numero 9.

    ERIC Educational Resources Information Center

    Ostiguy, Luc; Gagne, Gilles

    An approach to elementary school French language instruction emphasizes sustained oral language through language analysis. The guide is intended for teachers of grades 3-6. It contains an introductory section, an explanation of the approach, a brief discussion of the linguistic content of oral language instruction, and four communicative classroom…

  11. Alpha One Foundation

    MedlinePlus

    Languages French (Francais) German (Deutsch) Italian (Italiano) Spanish (Español) Portuguese (Portugues) Swedish (Svenska) Donate One Time Monthly Keep In Touch | About Us | Contact Us | What is the Alpha-1 ...

  12. La theorie autrement (Theory in Another Light).

    ERIC Educational Resources Information Center

    Bertocchini, Paola; Costanzo, Edwige

    1985-01-01

    Outlines a technique using articles from "Le Francais dans le Monde" to teach reading comprehension and theory simultaneously to teachers of French as a second language. Describes a program in Italy using this approach. (MSE)

  13. Control of Large-Scale Civil Conflicts in Democratic Nigeria

    DTIC Science & Technology

    2007-11-02

    country. On the 7 other hand, the federal government handles the lucrative taxes from imports, customs, excises , business and mining. The states generate...Adisa (Ibadan, Nigeria: Institut Francais de Recherche en Afrique , 1994), 115. 8 Isaac Olawale Albert, Introduction to Third-Party Intervention in...Institut Francais de Recherche en Afrique , 2001),3. 10 Isaac Olawale Albert, Introduction to Third-Party Intervention in Community Conflicts (Ibadan

  14. Testing Lorentz Invariance with Laser-Cooled Cesium Atomic Frequency Standards

    NASA Technical Reports Server (NTRS)

    Klipstein, William M.

    2004-01-01

    This slide presentation reviews the Lorentz invariance testing during the proposed PARCS experiment. It includes information on the primary atomic reference clock in space (PARCS), cesium, laser cooling, and the vision for the future.

  15. Modeles de rendement langagier: French Language Arts--7e annee. Francais langue seconde--immersion (Models of Linguistic Production--French as a Second Language/Immersion: 7th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for seventh grade students…

  16. Bibliographie annotee 4-6--Francais langue seconde-immersion: Selection d'ouvrages de la litterature jeunesse (Annotated Bibliography 4-6--French as a Second Language-Immersion: Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This annotated bibliography of children's literature presents 74 books and stories that can be used in the classroom to introduce literature in French to children in fourth through sixth grades. The selected texts (51 titles in fiction and 23 titles in non-fiction) were chosen for their age-appropriate language and themes, as well as their…

  17. Modeles de rendement langagier: French Language Arts--8e annee. Francais langue seconde--immersion: (Models of Linguistic Production--French as a Second Language/Immersion: 8th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for eighth grade students…

  18. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Huitieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Eighth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for eighth-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  19. Bibliographie annotee 4-6--Francais langue premiere: Selection d'ouvrages de la litterature jeunesse (Annotated Bibliography 4-6--French as a Native Language: Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This annotated bibliography of children's literature presents 85 books and stories that can be used in the classroom to introduce literature in French to children in fourth through sixth grades. The selected texts (64 titles in fiction and 21 titles in non-fiction) were chosen for their age-appropriate language and themes, as well as their…

  20. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Septieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Seventh Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for seventh-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  1. Bibliographie Annotee M-3: Francais langue seconde--immersion. Selection d'ouvrages de la litterature enfantine (Annotated Bibliography M-3: French as a Second Language--Immersion. Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    This annotated bibliography of children's literature presents over 150 books, stories and songs that can be used in the French language classroom to introduce literature in French to children in Kindergarten through third grade. The selected texts (97 titles in fiction and 62 titles in non-fiction) were chosen for their age-appropriate language…

  2. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Neuvieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Ninth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for ninth-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  3. French Language Arts: Programme d'etudes du secondaire deuxieme cycle (10-12). Francais langue seconde--immersion (French Language Arts: High School Curriculum [10-12]. French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for high school French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  4. Modeles de rendement langagier: French Language Arts--9e annee. Francais langue seconde--immersion (Models of Linguistic Production--French as a Second Language/Immersion: 9th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. Three separate lesson plans in the…

  5. Evaluation en francais de base: La production orale et ecrite, secondaire 1 et 4, 1993. Rapport sommaire (Basic French Assessment: Speaking and Writing Skills, Senior 1 and 4, 1993. Summary Report).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    The report, entirely in French, summarizes an assessment of the extent to which Manitoba schools are meeting the learning objectives for speaking and writing skills specified for senior (secondary) levels 1 and 4 in the basic French curriculum for the province. For each level and skill area, a random sample of students representing urban and rural…

  6. Evaluation en francais de base: La production orale et ecrite, secondaire 1 et 4, 1993. Rapport global (Basic French Assessment: Speaking and Writing Skills, Senior 1 and 4, 1993. Final Report).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    The report, entirely in French, details an assessment of the extent to which Manitoba schools are meeting the learning objectives for speaking and writing skills specified for senior (secondary) levels 1 and 4 in the basic French curriculum for the province. For each level and skill area, a random sample of students representing urban and rural…

  7. "Travaillez, sinon vous serez orientes": essai sur les difficultes actuelles des colleges et lycees francais ("Work, Or You Will Be Counseled out of Education": Essay on the Current Difficulties of French Proprietary and Secondary Schools).

    ERIC Educational Resources Information Center

    Prost, Antoine

    1985-01-01

    The French situation, in which the proprietary and upper-level secondary schools may contain a large number of "high-risk" or marginally qualified students, and proposed solutions to the problem, are described and discussed. (MSE)

  8. De L'Economie des moyens linguistiques en francais et en anglais dans l'usage standard contemporain (On the Economy of Linguistic Means in French and English Standard Contemporary Usage).

    ERIC Educational Resources Information Center

    Calve, Pierre

    1989-01-01

    The conciseness and "ease of use" often attributed to North American English relative to French in standard contemporary usage is explained in terms of English morpho-syntactic structure and of the values of the classical norm and rhetoric affecting French. (Author/MSE)

  9. Le lexique anglais-francais de l'industrie miniere de l'Office de la langue francaise (The English-French Lexicon of the Mining Industry prepared by the Office of the French Language)

    ERIC Educational Resources Information Center

    Rousseau, Louis-Jean

    1974-01-01

    This article describes research methods involved in compiling a lexicon of terms used in the mining industry. This consisted mainly in contrasting terms found in dictionaries with actual usage in spoken and written language. (Text is in French) (AM)

  10. Enquete sur le langage de l'enfant francais: Transcriptions de conversations d'enfants de 9 ans (Investigation of the Language of French Children: Transcriptions of Conversations of 9-Year-Olds). Document No. 1.

    ERIC Educational Resources Information Center

    Leclercq, Janine, Comp.

    These transcriptions of children living in a suburb of Paris represent and illustrate linguistic behavior and interests of the average nine-year-old French child. Seventy-nine children in groups of three were recorded in 30-minute periods of free conversation and 10-minute periods of play. Analysis reveals more than 30 centers of interest which…

  11. Enquete sur le langage de l'enfant francais: Transcriptions de conversations d'enfants de 10 ans (Investigation of the Language of French Children: Transcriptions of Conversations of Ten-Year-Olds). Document No. 2.

    ERIC Educational Resources Information Center

    Leclercq, Janine, Comp.

    These transcriptions of conversation illustrate linguistic behavior and interests of the average ten-year-old French child. Patterned after a previously transcribed series of conversations of nine-year olds, the 14 dialogues in this collection serve as a linguistic corpus suitable for educational research and textbook development. A graphic code…

  12. Le langage des "gendarmes" et des "voleurs": etude comparative du vocabulaire de la pegre et de la police en francais et en anglais ("Cops" and "Robbers" Language: A Comparative Study of the Underworld and Police Vocabulary of French and English).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1981-01-01

    Discusses the meaning and origins of the word "argot," its cryptic character, and its function in a closed social group, focusing on a comparative description of the French and Anglo-American vocabulary of the underworld and the police. Comments on shared traits and provides an insight into the differences. (MES)

  13. Affirming Francophone Education: Foundations and Directions. A Framework for French First Language Education in Alberta = Affirmer l'education en francais langue premiere: fondements et orientations. Le cadre de l'education francophone en Alberta.

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This booklet presents a clear and succinct description of the educational needs of francophone students, families, and communities, and how this all fits into the constitutional requirements of Canada as directed by the 1982 Canadian Charter of Rights and Freedoms and all subsequent amendments and Canadian Supreme Court rulings. It identifies the…

  14. Francais de base. Programme de 9 ans, materiel didactique: 4e, 5e et 6e annees (Core French. Nine-Year Study Program, Instructional Materials: 4th, 5th and 6th Grades).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    Official instructional materials for the first three years (grades 4-6) of the Manitoba Department of Education's core French language program consist of units in geography, weather and calendars, holidays, and music designed for each of the three instructional levels. The units on geography focus on Manitoba and Canada. Units on the calendar and…

  15. Une epreuve orale de francais en fin d'etudes de gestion. Construction et implications pedagogiques (An Oral French Exam at the End of a Marketing Program. Construction and Pedagogical Implications).

    ERIC Educational Resources Information Center

    Crawshaw, Robert H.

    1984-01-01

    An oral language test administered at the end of a four-year program combining business administration and French is described. The test consists of the formal presentation of a report including numbers, graphics, and text, a discussion of a theoretical issue, and interview. (MSE)

  16. Bibliographie annotee 4-6--Francais langue seconde-immersion: Selection d'ouvrages de la litterature jeunesse. Supplement 2001 (Annotated Bibliography 4-6--French as a Second Language-Immersion: Selection of Works from Children's Literature. Supplement 2001).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    The document comprises 42 inserts to be included in the List of Books (4-6) for French as a Second Language (Immersion)--a selection of works of youth literature--published by Alberta Learning in 2000. Thirty-seven of the items appeal to the world of imagination and esthetics, and five items are of an informative nature. An appendix, entitled "How…

  17. A propos d'une typologie des objectifs possibles d'un enseignement "du" francais aux adultes en formation (Concerning a Typology of Possible Objectives in Teaching French to Continuing Education Students).

    ERIC Educational Resources Information Center

    Mariet, Francois

    1977-01-01

    Proposes an approach to French language instruction which stresses themes, such as literature, law, economics, and management, rather than specific occupational levels, so as to respect the needs of adult continuing education students of all socioeconomic levels. (AM)

  18. Problemes poses par la mesure du rendement en francais des eleves franco-ontariens (Problems Posed by the Measurement of Proficiency in French Among Franco-Ontarian Students). Working Papers on Bilingualism, No. 16.

    ERIC Educational Resources Information Center

    Canale, Michael; Mougeon, Raymond

    This study examines the hypothesis that the French used by a large number of Franco-Ontarians represents a linguistic system (or several systems) that differs from Standard French. In addition, a review of previous research leads to the inverse hypothesis, that Ontarian French represents a body of different systems or sub-systems that are more or…

  19. Acquisition et enseignement du francais en situation minoritaire: le cas des Franco-ontariens (French Acquisition and Teaching in a Minority Situation: The Case of the Franco-Ontarians).

    ERIC Educational Resources Information Center

    Mougeon, Raymond; And Others

    1984-01-01

    A synthesis of research on the Franco-Ontarian school environment focuses on the maintenance of French by Franco-Ontarian students, their French language proficiency, and their native language instruction. The relevance of these issues in other French language minority settings is discussed. (MSE)

  20. Le francais parle: analyse des attitudes des adolescents de la ville de Quebec selon les classes sociales (Spoken French: An Analysis of the Attitudes of Adolescents in Quebec City according to Social Class).

    ERIC Educational Resources Information Center

    Noel, Daniele

    This is a report on a study of the attitudes of French-speaking young people, aged 10 to 17 years, toward French as it is spoken in two sectors of Quebec City. One sector, Sainte-Foy, is mainly upper middle class; the other, Saint-Sauveur, is economically and socially disadvantaged. The research was carried out on the basis of work in French and…

  1. Vingt-cinq ans dans l'evolution d'une politique de diffusion du francais (Twenty-Five Years in the Evolution of the Politics of the Diffusion of French).

    ERIC Educational Resources Information Center

    Boulanger, Lionel; Daniel, Pierre

    1984-01-01

    The theme of a conference in honor of the centennial of a famous French teaching institution was the 25-year French policy of spreading the French language internationally. Discussions focused on the cultural politics involved and their institutionalization, and the evolution of methods to carry out this policy through the medium of linguistic…

  2. French registry of acute leukemia and myelodysplastic syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Groupe Francais de Morphologie Hematologique

    SciTech Connect

    Not Available

    1987-09-15

    During 1982 and 1983, 4496 new cases were recorded in the French Registry of acute leukemia and myelodysplastic syndromes by the French Group of Hematologic Morphology. This cooperative group associated members of 37 university centers spread throughout France; these centers handle the overwhelming majority of acute leukemias diagnoses. The cases were all classified according to FAB guidelines. Two thousand four hundred ninety-nine cases of acute myeloid leukemia were recorded, with similar total recruitment and distribution by cytologic subclass for both years. Hemogram data analysis revealed significant differences between different classes for certain parameters, particularly leukocytosis. A greater proportion of the acute myelogenous leukemias (AMLs) secondary to chemotherapy and/or radiotherapy (n = 145) were unclassifiable according to the French-American-British (FAB) system than the de novo AMLs (n = 1954). Eight hundred twenty cases of myelodysplastic syndromes were analyzed. Their frequency was underestimated due to optional reporting during the first year and the less favorable position of the university centers for recruiting these syndromes. The characteristics of the hemograms were established for acquired idiopathic sideroblastic anemia (n = 107), refractory anemia with excess blasts (RAEB) (n = 329), chronic myelomonocytic leukemia (n = 129) and RAEB in transformation (n = 65). Analysis of the 1177 acute lymphoblastic leukemias (ALLs) recorded showed good stability from one year to the next in terms of numbers of cases and distribution in the subclasses L1, L2, and L3. The distribution among these three subclasses by age also was determined. For L1 and L2 the hemogram data were examined separately for adults and children. The study of 74 cases of type L3 ALL enabled us to detail the hematologic presentation of this rare form of leukemia.

  3. Avez-vous vu la meme chose que les Francais? Stereotypes et documents authentiques video. (Did You See the Same Thing as the French? Stereotypes and Authentic Video Documents).

    ERIC Educational Resources Information Center

    Wilczynska, Weronika

    1990-01-01

    This discussion treats cultural stereotypes as a significant issue in second-language instruction, and examines the role of video documents from the mass media in helping students perceive and understand such stereotypes. (MSE)

  4. La Technologie au service de l'enseignement/apprentissage du francais langue seconde: Survol du projet RECALL, 1985-91 (Foreign Language Instruction and Learning and Educational Technology: Survey of Project RECALL, 1985-91).

    ERIC Educational Resources Information Center

    Ducretet, Marie-Paule; And Others

    1992-01-01

    A French curriculum development and research project at Erindale College (Canada), established in 1985, studies and initiates incorporation of computer technology into the University of Toronto French program. Specific objectives include evaluation and adaptation of existing software, development of an undergraduate course in computer applications…

  5. Banque de strategies d'ecoute pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching listening skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It…

  6. Banque de strategies d'ecriture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for the Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, written in French, intended for the instruction of both French as a first language and French as a second language (immersion), provides a host of strategies for teaching writing skills in the classroom (grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the…

  7. Banque de strategies d'ecriture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching writing skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  8. Banque de strategies de production orale pour un enseignement explicite de la 6e a la 12e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  9. Banque de strategies de lecture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching reading skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  10. Banque de strategies de production orale pour un enseignement explicite de la 1re a la 7e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  11. Banque de strategies d'ecoute pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in immersion programs. It provides a host of strategies for teaching listening skills in the classroom in Grades 1 through 7. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  12. Banque de strategies de lecture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching reading skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  13. European Heritage Landscapes. An Account of the Conference on Planning and Management in European Naturparke/Parcs Naturels/National Parks (U.K.) and Equivalent Category "C" Reserves (Losehill Hall, Castleton, England, September 26-30, 1977).

    ERIC Educational Resources Information Center

    Smith, Roland

    Presented are the proceedings of the Conference on Planning and Management in European National Parks and equivalent Category "C" reserves held at the Peak National Park Study Center, Castleton, England, in 1977. Fifty-two representatives from 16 countries focused practical solutions to management and planning problems in national parks. (BT)

  14. Problemes en enseignement fonctionnel des langues (Problems in the Functional Teaching of Languages). Publication B-103.

    ERIC Educational Resources Information Center

    Alvarez, Gerardo, Ed.; Huot, Diane, Ed.

    Articles include: (1) "L'elaboration du materiel pedagogique pour des publics adultes" (The Elaboration of Teaching Materials for the Adult Public) by G. Painchaud-Leblanc, (2) "L'elaboration d'un programme d'etudes en francais langue seconde a partir des donnees recentes en didactique des langues" (The Elaboration of a Program…

  15. German Unification: Security Implications for Europe

    DTIC Science & Technology

    1990-07-01

    director of the Institut Francais des Relations Inter’nationales and editor of its journal, Politique Etrangere. ="Memorandum of the Ministry of Foreign...ecoloaical endeavors have spent most of the ’-=ea• e dividend ’ that resulted from the dramatic reduction in zhe armed forces of the nations of Europe. the

  16. Actes du colloque: Tendances actuelles de la recherche sur la langue parlee (Conference Presentations: Current Trends in Research on Oral Language).

    ERIC Educational Resources Information Center

    Auger, Julie, Ed.

    Student papers presented at a sociolinguistics conference include: "La variation phonologique [d'une voyelle] a Hull"; "La force illocutoire des pronoms personnels 'je' et 'tu' en tant qu'insignes des places d'ou parlent les femmes et les hommes"; "L'emploi des modes indicatif et subjonctif dans le francais parle de la…

  17. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (15th, Quebec, Canada, March 15-16, 2001).

    ERIC Educational Resources Information Center

    Goulet, Marie-Josee, Ed.

    Papers on language research in this volume include the following: "Temporalite en francais de France. Differences dans la conceptualisation du temps et son expression dans un texte narratif oral" ("Differences in the Conceptualization of Time and Its Expression in Oral Narratives") (Natalia Dankova); "La traduction des…

  18. Travaux Neuchatelois de Linguistique (TRANEL) (Neuchatel Working Papers in Linguistics), Volume 14.

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.; Rubattel, Christian, Ed.

    1989-01-01

    Three papers in linguistics, all in French, are presented. "La delocutivite lexicale en francais standard: esquisse d'un modele derivationnel" ("Lexical Delocutivity in Standard French: Sketch of a Derivational Model"), by Marc Bonhomme, examines the process by which certain expressions become neologisms. "La terminologie…

  19. Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

    ERIC Educational Resources Information Center

    Mazur, Gertrud S., Ed.

    The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic…

  20. The Training of Modern Language Teachers in Various Countries. Collection d'"Etudes linguistiques," No. 20. Selected papers from the Association Internationale pour la Recherche et la Diffusion des Methodes Audio-Visuelles et Structuro-Globales Seminar (5th, August 27-September 1, 1973).

    ERIC Educational Resources Information Center

    Nivette, Jos, Ed.

    Selected papers that address theoretical and practical training of the modern language teacher and language teaching experiments in various countries are presented. Some of the articles included are the following: "Les problemes de la formation linguistique et pedagogique des professeurs de francais en Afrique Subsaharienne" (The…

  1. Paradoxes in French-Language Instruction: Recent Social and Historical Research on Literacy in France

    ERIC Educational Resources Information Center

    Rockwell, Elsie; Galvao, Ana Maria

    2012-01-01

    This essay on three recent books by outstanding scholars--"La raison scolaire" by Bernard Lahire, "Histoire de l'enseignement du francais du XVII[superscript e] au XX[superscript e] siecle" by Andre Chervel, and "L'ecole et la lecture obligatoire" by Anne-Marie Chartier--offers the opportunity to acquaint readers with…

  2. Melanges Pedagogiques (Pedagogical Mixture), 1986/87.

    ERIC Educational Resources Information Center

    Melanges Pedagogiques, 1987

    1987-01-01

    The 1986/87 issue of the journal on second language teaching and learning contains seven articles in French and four in English, including: "Learning How To Learn English"; "Socrate est-il un chat? Pratiquer le syllogisme pour apprendre a argumenter (Is Socrates a Cat? Practicing Syllogisms To Learn To Argue)"; "La production orale en francais des…

  3. EPA/IFP EUROPEAN WORKSHOP ON THE EMISSION ON NITROUS OXIDE FROM FOSSIL FUEL COMBUSTION

    EPA Science Inventory

    The report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increas...

  4. Travaux du laboratoire de traitement du langage et de la parole (Laboratory Work in the Treatment of Language and Linguistics).

    ERIC Educational Resources Information Center

    Grosjean, Francois, Ed.

    1994-01-01

    Research papers on language and linguistics include: "Enchainement des mots et acces au lexique en francais" ("Word Order and Lexical Access in French") (Besson); "L'apport de la coarticulation dans la perception de consonnes occlusives et constrictives" ("The Contribution of Coarticulation to the Perception of…

  5. Discours oraux--discours ecrits: quelles relations? Actes du 4eme colloque d'orthophoine/logopedie (Neuchatel, 3-4 octobre, 1996) (Oral Discourse--Written Discourse: What Is the Relationship? Proceedings of the Colloquium on Speech Therapy (4th, Neuchatel, Switzerland, October 3-4, 1996).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    1996-01-01

    Research papers on the relationship between oral and written language include: "Une distinction bien fragile: oral/ecrit" ("A Fragile Distinction: Oral/Written") (Francoise Gadet); "Oral et ecrit dans les representations des enseignants et dans les pratiques quotidiennes de la classe de francais" ("Oral and Written Language in Teachers'…

  6. Games for the Foreign Language Classroom.

    ERIC Educational Resources Information Center

    McMillan, Nancy; Madaras, Susan W.

    Two marketing games are described, "Le Marche Francais" and "El Mercado: The Mexican Market Comes to Life in the Spanish Classroom." Both are patterned after a published game entitled "Market: A Simulation Game." The adaptation in each instance relied on simplifying the original game and presenting it in a form understandable to middle school…

  7. Melanges, No. 23.

    ERIC Educational Resources Information Center

    Melanges, 1997

    1997-01-01

    Articles on second language teaching and learning include: "Ethnographie comparee de la salle de classe en France et en grande-Bretagne" (Comparative Ethnography of the Classroom Environment in France and Great Britain) (F. Carton); "Pour une approche micro et macro du francais parle dans la formation des enseignants de FLE"…

  8. Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton.

    The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The…

  9. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (12th, Quebec City, Canada, March 26-27, 1998).

    ERIC Educational Resources Information Center

    Boissonneault, Chantal, Ed.

    Papers on language research include: "L'expression de l'opposition en Latin" ("The Expression of Opposition in Latin" (Claude Begin); "Le francais de l'Abitibi: characteristiques phonetiques et origine socio-geographique des locuteurs" ("The French of Abitibi: Phonetic Characteristics and Socio-Geographic Origin…

  10. ENGLISH AS A SECOND LANGUAGE FOR FRENCH-SPEAKING STUDENTS IN SECONDARY SCHOOLS.

    ERIC Educational Resources Information Center

    Ontario Curriculum Inst., Toronto.

    THIS REPORT WAS SUBMITTED IN JULY 1965 BY THE FRANCAIS SUB-COMMITTEE AND THE MODERN LANGUAGE COMMITTEE TO THE ONTARIO CURRICULUM INSTITUTE. THE SUBJECT WAS A SURVEY UNDERTAKEN IN 1964 TO STUDY THE TEACHING OF ENGLISH IN CANADIAN SECONDARY SCHOOLS ATTENDED BY FRENCH-SPEAKING STUDENTS. THE FUNDAMENTAL ISSUE INVOLVED IN THE SECONDARY EDUCATION OF…

  11. Actes des journees de linguistique: Colloque sur la recherche etudiante (Proceedings of the Linguistics Conference: Colloquium on Student Research) (Quebec, Canada, March 18-19, 1988).

    ERIC Educational Resources Information Center

    Lepage, Danielle, Ed.; Dominik, Annette, Ed.

    Presentations by students at a colloquium on student research on the occasion of the 50th anniversary of the University of Laval's Faculty of Letters, March 18-19, 1988, include: "Une enquete sur la qualite du francais ecrit au Quebec"; "Amenagement linguistique et neologie"; "Analyse syntaxique des 'arrets et retours' en…

  12. Melanges Pedagogiques (Pedagogical Mixture), 1985.

    ERIC Educational Resources Information Center

    Melanges Pedagogiques, 1985

    1985-01-01

    The 1985 issue of the journal on second language teaching and learning contains four articles in French and three in English, including: "Lire et comprendre un texte informatif (Reading and understanding an Informative Text)" (Jacqueline Billant, Pascale Fade); "Les nouveaux diplomes de Francais Language Etrangere: Le D.E.L.F. et le…

  13. The French Language in the Americas.

    ERIC Educational Resources Information Center

    Valdman, Albert, Ed.

    The annual bulletin of the French 8 section of the Annual Meeting of the Modern Language Association of America is presented with the texts of papers read at both the 1969 and 1970 sessions. The 1970 papers, in French, include Jean Louis Darbelnet's "Etude Sociolinguistique des contacts entre 1'Anglais et le Francais au Canada et en…

  14. Indexing Price Trends of French Academic Books in the Humanities and Social Sciences.

    ERIC Educational Resources Information Center

    Austin, Ronald E.

    1994-01-01

    Provides data on price trends for French academic books in the humanities and social sciences for the years 1986-90 based on information from the "Bulletin Critique du Livre Francais," a monthly book-reviewing journal. A method for developing a price index for this material is demonstrated. (Contains eight references.) (LRW)

  15. Multilingual Thesauri for the Modern World - No Ideal Solution?

    ERIC Educational Resources Information Center

    Jorna, Kerstin; Davies, Sylvie

    2001-01-01

    Discusses thesauri as tools for multilingual information retrieval and cross-cultural communication. Considers the need for multilingual thesauri and the importance of explicit conceptual structures, and introduces a pilot thesaurus, InfoDEFT (Information Deutsch-English-Francais Thesaurus), as a possible model for new online thesauri which are…

  16. Speaking Personally--With John Seely Brown

    ERIC Educational Resources Information Center

    American Journal of Distance Education, 2008

    2008-01-01

    This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

  17. Francais langue etrangere en milieu homoglotte et alloglotte: quels enseignements pour quelles pratiques effectives, quelles pratiques effectives apres quels enseignements? (French as a Foreign Language in Homoglot and Alloglot Environments: What Lessons To Teach for Which Effective Practices, Which Effective Practices Follow What Lessons?)

    ERIC Educational Resources Information Center

    Gauthier, Claude, Ed.; Jeanneret, Therese, Ed.

    2000-01-01

    The articles in this volume are based on a survey of language learners carried out at five Swiss universities. The surveys (done through interviews and questionnaires) concern the ways that students encounter their second language (French) outside the classroom, and which of those practices are the most effective in improving their French. The…

  18. La Crise est arrivee: la croissance des programmes de francais langue seconde et ses repercussions sur la qualite et le nombre des enseignants (The Crisis Has Arrived: The Growth of French as a Second Language Programs and Repercussions for the Quality and Number of Teachers).

    ERIC Educational Resources Information Center

    Obadia, Andre A.

    1989-01-01

    A study of faculties of education in Canadian universities shows that the quality of French teacher training needs improvement and may run the risk of further deterioration. The tremendous student increase in French-as-a-Second-Language programs is already causing a gradual but serious shortage of French teachers. (Author/MSE)

  19. Le role des capacites metalinguistiques et de la competence langagiere orale dans l'apprentissage de la lecture en francais langage premiere et seconde (The Role of Metalinguistic Capacities and Oral Language Skills in Learning Reading in French as a First and Second Language).

    ERIC Educational Resources Information Center

    Armand, Francoise

    2000-01-01

    Analyzes the role played by oral language skills and by metalinguistic capacities in the reading performance of young beginner readers in French as a second language who are in a situation of successive bilingualism and observing whether differences exist between them and their francophone peers of the same age. (Author/VWL)

  20. Les mammiferes aquatiques: lexique anglais-francais des mammiferes marins actuels ou recemment disparus, y compris les especes d'eau douce des groupes surtout marins (Aquatic Mammals: English-French Glossary of Livinq or Recently Extinct Marine Mammals, Including the Fresh Water Species of Prevalently Marine Groups).

    ERIC Educational Resources Information Center

    Nekrassoff, Vladimir N.

    1980-01-01

    Introduces a new glossary of aquatic mammals representing recent taxonomic revisions. Describes its design, which consists of the glossary proper, listing the scientific name of each entry followed by its English and French equivalents, and of two indexes, listing other common names for the same entries referred back to the scientific term. (MES)

  1. Tu peux compter sur moi: Guide a l'intention du parent pour l'accompagnement de l'enfant dans son education en francais langue premiere (You Can Count on Me: Guide for Parents for Accompanying Their Child in French as a First Language Education).

    ERIC Educational Resources Information Center

    Federation des parents francophones de l'Alberta, Edmonton (Canada).

    This guidebook is intended for parents of French-speaking students in Alberta. It describes French-as-a-first-language education in Alberta and provides information to help parents, in collaboration with school personnel and the wider francophone community in Alberta, to preserve and develop their children's identity as speakers of French and as…

  2. Francais langue seconde: trousse d'evaluation--tests modeles pour le niveau debutant 1, niveau debutant 2, niveau debutant 3 des ecoles elementaires (French as a Second Language: Evaluation Resource Package--Model Tests for Beginning Level 1, Beginning Level 2, Beginning Level 3 in Elementary Schools).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The French as a Second Language model tests for beginning levels 1, 2, and 3 were designed to evaluate students' language performance, as outlined in the program of studies for Alberta, Canada, in listening and reading comprehension and oral and written production, communication skills, culture, language and general language knowledge. The tests…

  3. (Biotechnology for the conversion of lignocellulosics)

    SciTech Connect

    Woodward, J.

    1990-10-25

    This report summarizes the results of the traveler's participation in the International Energy Agency (IEA) Network planning meeting for Biotechnology for the Conversion of Lignocellulosics,'' held at the Institut Francais du Petrole (IFP), Rueil-Malmaison, France. It also summarizes the results of discussions held at Aston University, Birmingham, UK, with Dr. Martin Beevers with whom the traveler is attempting to initiate a collaborative research project that will be beneficial to ongoing research programs at Oak Ridge National Laboratory (ORNL). The itinerary for the trip is given in Appendix A; the names of the people contacted are listed in Appendix B. Also, pertinent information about the Institut Francais du Petrole is attached (Appendix C). 1 tab.

  4. Tooling for War: Military Transformation in the Industrial Age

    DTIC Science & Technology

    1994-09-01

    Francais Face aux Repercussions Militaires de la Revolution Technique et Industrielle de 1919 a 1940 : Le Facteur "Renseignement"." Revue Internationale...War on Wheels: The Evolution of an Idea. Harrisburg: Military Service, 1940 . UG 446.5 .K9. Ogorkiewicz, Richard M. Armor: A History of Mechanized...States Government. 1940 -1945. Princeton: Princeton UP, 1945. Library also has 1978 reprint: QC 773.3 .US S67 1978. QC 773 .S66. Tsipsis, Kosta. "Third

  5. Logic Programming in LISP.

    DTIC Science & Technology

    1981-01-01

    79/7, Imperial College, University of London. [Colmerauer 1973] Colmerauer, A., Un Systeme de Communication Homme - machine Kanoui, H., en Francais...any of the LOGIC interface functions (,-, THE, ALL, ANY, etc.) can be obtained by invoking the command (DOC fn), where "fn" is the name of the function...well as for output) illustrates one more way in which the LOGLISP programmer can fruitfully exploit the interface between LOGIC and LISP. GIVE is just a

  6. Design and Implementation of Practical Constraint Logic Programming Systems

    DTIC Science & Technology

    1992-08-24

    Pasero, and P. Roussel. Une systeme de com- munication homme-machine en Francais. Technical report, Groupe Intelligence Artificielle , Universite Aix...Marseille II, France, 1973. [28] Alain Colmerauer. PROLOG II reference manual and theoretical model. Techni- cal report, Groupe Intelligence ... Artificielle , Universit6 Aix - Marseille II, October 1982. [29] Alain Colmerauer. Equations and inequations on finite and infinite trees. In Pro- ceedings of the

  7. Light pollution in Valencian Natural Parks: where light not only annoys astronomers

    NASA Astrophysics Data System (ADS)

    Marco, E.; Morales Rubio, A.; Bullón, J. M.

    2013-05-01

    Street lighting of the city of Valencia produces a yellowish halo that prevents astronomical observation. Moreover, within the metropolitan area, there are three natural parks: the Parc Natural de l'Albufera, the Parc Natural del Túria and the Parc Natural de la Calderona. The light pollution affects the nighttime wildlife parks. Therefore, since 2010, a campaign is being carried out in order to collect data but also to raise awareness and reporting of the harmful effects of excessive and incorrect installation of existing luminaires. Since 2012 this study has been extended to other Valencian natural parks far from Valencia. Their sky darkness is a value to preserve.

  8. Call for the international adoption of microbiological breakpoints for fluoroquinolones and Streptococcus pneumoniae.

    PubMed

    Schurek, Kristen N; Adam, Heather J; Hoban, Daryl J; Zhanel, George G

    2006-09-01

    The use of current Clinical and Laboratory Standards Institute levofloxacin breakpoints for assessing fluoroquinolone resistance in Streptococcus pneumoniae is inadequate for detecting isolates possessing first-step parC mutations. Consequently, the risk for development of fluoroquinolone resistance is greatly underestimated. Adopting microbiological breakpoints for fluoroquinolones and S. pneumoniae, where parC mutations are rare in susceptible isolates, more accurately describes the emergence of resistance and may help to prevent a number of future fluoroquinolone treatment failures. Additionally, we propose that the use of a second fluoroquinolone marker, such as ciprofloxacin, offers the best prediction for detecting an isolate possessing a first-step parC mutation.

  9. MIT Laboratory for Computer Science Progress Report 27

    DTIC Science & Technology

    1990-06-01

    Link Chip (DLC). These components were discussed in some detail in last year’s progress report. PaRC is a CMOS gate array designed by Chris Joerg that...burdening the network. Chris Joerg has finished the design of PaRC and the generation of a complete set of test vectors. PaRC has 33,000 used gates and is...N. Lynch, Y. Mansour, and J Spinelli . The Data Link Layer: The Impos- sibility of Implementation in Face of Crashes. Technical Memo MIT/LCS/TM-355.b

  10. First Characterization of Fluoroquinolone Resistance in Streptococcus suis▿

    PubMed Central

    Escudero, Jose Antonio; San Millan, Alvaro; Catalan, Ana; de la Campa, Adela G.; Rivero, Estefania; Lopez, Gema; Dominguez, Lucas; Moreno, Miguel Angel; Gonzalez-Zorn, Bruno

    2007-01-01

    We have identified and sequenced the genes encoding the quinolone-resistance determining region (QRDR) of ParC and GyrA in fluoroquinolone-susceptible and -resistant Streptococcus suis clinical isolates. Resistance is the consequence of single point mutations in the QRDRs of ParC and GyrA and is not due to clonal spread of resistant strains or horizontal gene transfer with other bacteria. PMID:17116660

  11. MATERNAL ROLE CONFUSION: RELATIONS TO MATERNAL ATTACHMENT AND MOTHER–CHILD INTERACTION FROM INFANCY TO ADOLESCENCE

    PubMed Central

    VULLIEZ-COADY, LAURIANE; OBSUTH, INGRID; TORREIRO-CASAL, MONICA; ELLERTSDOTTIR, LYDIA; LYONS-RUTH, KARLEN

    2014-01-01

    Self-reports of role confusion with the parent in childhood are associated with a variety of adverse outcomes. However, role-confusion has been studied primarily from the point of view of the child. The current study evaluated an instrument for assessing role confusion from maternal interviews rather than from child observations or self-reports in adulthood. Fifty-one mothers participating in a longitudinal study since their own child’s infancy were administered the Experiences of Caregiving Interview (C. George & J. Solomon, 1996) when the child was age 20. Interviews were coded using the newly developed Parental Assessment of Role Confusion (PARC; L. Vulliez-Coady & K. Lyons-Ruth, 2009). Maternal PARC scores were related to observational measures of role-confusion in interaction with the child both in infancy and late adolescence. PARC scores also were related to mothers’ hostile-helpless states of mind on the Adult Attachment Interview (C. George, N. Kaplan, & M. Main, 1984, 1985, 1986) and to the extent of Unresolved loss, but not Unresolved Trauma. PARC scores also were related to mothers’ self-reports of helplessness experienced in the parenting role. Discriminant validity of the PARC was demonstrated in that role confusion on the PARC was not related to hostile or disoriented forms of parent–child interaction. Implications for clinical assessment of role confusion are discussed. PMID:25544789

  12. Essais d'application d'un cadre de reference pragmatique a la realisation de materiels d'apprentissage du francais langue etrangere. L'Enseignement de la competence de communication en langues secondes. (An Attempt to Apply a Pragmatic Frame of Reference to the Production of Materials for the Study of French as a Second Language). The Teaching of Communicative Competence in Second Languages. Acts of the Colloquim of the Swiss Interuniversity Commission for Applied Linguistics. CILA Bulletin.

    ERIC Educational Resources Information Center

    Richterich, Rene

    Second language learning today requires new materials. One type of learning unit suggested would have a simple format, limited scope and objectives, and diversity of content, form, learning strategies and activities. In spite of the problems involved in the production of this format, such units might be worked out in teacher-training programs, by…

  13. Francais langue etrangere: l'enseignement de l'orthographe elementaire aux adolescents mal scolarises issus de milieux socio-culturels defavorises. Quelques notes sur une recherche (French as a Foreign Language: The Teaching of Elementary Spelling to Adolescents Who Were Slow Learners and Who Had Come from Disadvantaged Milieux. Some Research Notes). Acts of the Colloquium of the Swiss Interuniversity Commission for Applied Linguistics. CILA Bulletin, No. 25.

    ERIC Educational Resources Information Center

    Rey-von-Allmen, Micheline

    The reflections in this paper represent part of a study of disadvantaged 13 to 15 year-old children of immigrants in Switzerland. This section deals with the process of learning spelling. In order to observe the students' learning, the same dictation was given four times during the school year. The results were studied intuitively and…

  14. Western European Nuclear Forces. A British, a French, and an American View.

    DTIC Science & Technology

    1995-01-01

    87. See also Martin S. Alexander and Philip C. F. Bankwitz, "From Politiques en Kepi to Military Technocrats: de Gaulle and the Recovery of the...1988," in Dominique David (ed.), La politique de defense de la France, Fondation pour les Etudes de Defense Nationale, Paris, 1989, p. 311. 16Pierre...d’ceuvre en peril: le consensus francais sur la defense," Esprit, March 1988, special issue, La France en politique , pp. 71-82. David S. Yost, "France

  15. LNG projects make progress in Oman and Yemen

    SciTech Connect

    1997-02-24

    Two LNG projects in the Middle East, one in Oman and the other in Yemen, are due on stream at the turn of the century--each the largest single project ever put together in its country. Officials described their projects at a yearend 1996 conference in Paris by Institut Francais du Petrole and Petrostrategies. The Oman project develops gas reserves, does gas processing, and transports the gas 360 km to a liquefaction plant to be built on the coast. The Yemen project involves a liquefaction plant and an export terminal.

  16. The Feasibility of Oil Analysis for Air Force Diesel Engines

    DTIC Science & Technology

    1979-06-01

    period 18 September 1978 to 18 June 1979. The Air F’orce Project Monitor was MrW~ le MaW e, - an rton16h ALC /MMET,’ . Mr. J,P. Cuellar, Jr., of SwRI...insolub les 28 TABLE 5. RELATION OF USED CRANKCASE OIL ANALYSIS TO ENGINE CONDITION OR OPERATION (Cont’d) Contributing Engine Condition Test Result...guidelines for wearmetal and lubricant control limits. 46. Schilling, A. (Chief Engineer, Institut Francais du Petrole ), Automobile Engine Lubrication, 1972

  17. Application of an improved proteomics method for abundant protein cleanup: molecular and genomic mechanisms study in plant defense.

    PubMed

    Zhang, Yixiang; Gao, Peng; Xing, Zhuo; Jin, Shumei; Chen, Zhide; Liu, Lantao; Constantino, Nasie; Wang, Xinwang; Shi, Weibing; Yuan, Joshua S; Dai, Susie Y

    2013-11-01

    High abundance proteins like ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) impose a consistent challenge for the whole proteome characterization using shot-gun proteomics. To address this challenge, we developed and evaluated Polyethyleneimine Assisted Rubisco Cleanup (PARC) as a new method by combining both abundant protein removal and fractionation. The new approach was applied to a plant insect interaction study to validate the platform and investigate mechanisms for plant defense against herbivorous insects. Our results indicated that PARC can effectively remove Rubisco, improve the protein identification, and discover almost three times more differentially regulated proteins. The significantly enhanced shot-gun proteomics performance was translated into in-depth proteomic and molecular mechanisms for plant insect interaction, where carbon re-distribution was used to play an essential role. Moreover, the transcriptomic validation also confirmed the reliability of PARC analysis. Finally, functional studies were carried out for two differentially regulated genes as revealed by PARC analysis. Insect resistance was induced by over-expressing either jacalin-like or cupin-like genes in rice. The results further highlighted that PARC can serve as an effective strategy for proteomics analysis and gene discovery.

  18. Large-scale neural networks and the lateralization of motivation and emotion.

    PubMed

    Tops, Mattie; Quirin, Markus; Boksem, Maarten A S; Koole, Sander L

    2017-02-09

    Several lines of research in animals and humans converge on the distinction between two basic large-scale brain networks of self-regulation, giving rise to predictive and reactive control systems (PARCS). Predictive (internally-driven) and reactive (externally-guided) control are supported by dorsal versus ventral corticolimbic systems, respectively. Based on extant empirical evidence, we demonstrate how the PARCS produce frontal laterality effects in emotion and motivation. In addition, we explain how this framework gives rise to individual differences in appraising and coping with challenges. PARCS theory integrates separate fields of research, such as research on the motivational correlates of affect, EEG frontal alpha power asymmetry and implicit affective priming effects on cardiovascular indicators of effort during cognitive task performance. Across these different paradigms, converging evidence points to a qualitative motivational division between, on the one hand, angry and happy emotions, and, on the other hand, sad and fearful emotions. PARCS suggests that those two pairs of emotions are associated with predictive and reactive control, respectively. PARCS theory may thus generate important new insights on the motivational and emotional dynamics that drive autonomic and homeostatic control processes.

  19. Thin-layer and full Navier-Stokes calculations for turbulent supersonic flow over a cone at an angle of attack

    NASA Technical Reports Server (NTRS)

    Smith, Crawford F.; Podleski, Steve D.

    1993-01-01

    The proper use of a computational fluid dynamics code requires a good understanding of the particular code being applied. In this report the application of CFL3D, a thin-layer Navier-Stokes code, is compared with the results obtained from PARC3D, a full Navier-Stokes code. In order to gain an understanding of the use of this code, a simple problem was chosen in which several key features of the code could be exercised. The problem chosen is a cone in supersonic flow at an angle of attack. The issues of grid resolution, grid blocking, and multigridding with CFL3D are explored. The use of multigridding resulted in a significant reduction in the computational time required to solve the problem. Solutions obtained are compared with the results using the full Navier-Stokes equations solver PARC3D. The results obtained with the CFL3D code compared well with the PARC3D solutions.

  20. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0103191

  1. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0100120.

  2. BWR transient analysis using neutronic / thermal hydraulic coupled codes including uncertainty quantification

    SciTech Connect

    Hartmann, C.; Sanchez, V.; Tietsch, W.; Stieglitz, R.

    2012-07-01

    The KIT is involved in the development and qualification of best estimate methodologies for BWR transient analysis in cooperation with industrial partners. The goal is to establish the most advanced thermal hydraulic system codes coupled with 3D reactor dynamic codes to be able to perform a more realistic evaluation of the BWR behavior under accidental conditions. For this purpose a computational chain based on the lattice code (SCALE6/GenPMAXS), the coupled neutronic/thermal hydraulic code (TRACE/PARCS) as well as a Monte Carlo based uncertainty and sensitivity package (SUSA) has been established and applied to different kind of transients of a Boiling Water Reactor (BWR). This paper will describe the multidimensional models of the plant elaborated for TRACE and PARCS to perform the investigations mentioned before. For the uncertainty quantification of the coupled code TRACE/PARCS and specifically to take into account the influence of the kinetics parameters in such studies, the PARCS code has been extended to facilitate the change of model parameters in such a way that the SUSA package can be used in connection with TRACE/PARCS for the U and S studies. This approach will be presented in detail. The results obtained for a rod drop transient with TRACE/PARCS using the SUSA-methodology showed clearly the importance of some kinetic parameters on the transient progression demonstrating that the coupling of a best-estimate coupled codes with uncertainty and sensitivity tools is very promising and of great importance for the safety assessment of nuclear reactors. (authors)

  3. In vitro pharmacodynamic evaluation of garenoxacin against quinolone-resistant Streptococcus pneumoniae.

    PubMed

    Fukuda, Yoshiko; Takahata, Masahiro; Sugiura, Yoko; Shinmura, Yuko; Nomura, Nobuhiko

    2012-02-01

    The bactericidal activity and resistance selectivity of garenoxacin against Streptococcus pneumoniae with mutations in ParC (S79F) or both GyrA (S81F) and ParC (D83Y and K137N) were investigated using in vitro pharmacokinetic models simulating plasma concentrations for a standard clinical regimen [400mg once daily (q.d.)]. The efficacy of garenoxacin was compared with that of levofloxacin (500 mg q.d.) and moxifloxacin (400mg q.d.). Garenoxacin showed excellent bactericidal activity against S. pneumoniae, including quinolone-resistant S. pneumoniae (QRSP), achieving ratios of area under the plasma concentration-time curve over 24h to minimum inhibitory concentration (AUC(0-24)/MIC) ≥ 26.3, without emerging resistant subpopulations. The area above the killing curves was greater and the time to achieve 99.9% killing was shorter for garenoxacin than the corresponding values for levofloxacin and moxifloxacin. No resistant subpopulations and no additional substitution of amino acids in GyrA or ParC emerged following treatment with garenoxacin. On the other hand, in the parC mutant strain, levofloxacin and moxifloxacin treatment caused an increase in the frequency of the resistant population and an additional substitution of amino acids in GyrA (levofloxacin, S81Y/F/C; moxifloxacin, S81Y or E85K). In QRSP with mutations in GyrA and ParC, levofloxacin had no bactericidal activity, whilst the bactericidal activity of moxifloxacin was less than that of garenoxacin; moreover, an additional substitution of amino acids in ParC (S79Y) was noted. In conclusion, garenoxacin corresponding to an oral dose of 400mg showed excellent bactericidal activity against S. pneumoniae, including QRSP, without the emergence of resistant mutants.

  4. Grepafloxacin, a dimethyl derivative of ciprofloxacin, acts preferentially through gyrase in Streptococcus pneumoniae: role of the C-5 group in target specificity.

    PubMed

    Morris, Julia E; Pan, Xiao-Su; Fisher, L Mark

    2002-02-01

    Grepafloxacin, a 5-methyl-7-piperazinyl-3"-methyl analogue of ciprofloxacin, was used to obtain stepwise-selected mutants of Streptococcus pneumoniae 7785. Analysis of the quinolone resistance-determining regions of the gyrA, gyrB, parC, and parE genes in these mutants revealed that gyrA mutations preceded those in parC. Given that ciprofloxacin (5-H,7-piperazinyl) and AM-1121 (5-H,7-piperazinyl-3"-methyl) both act through topoisomerase IV, we conclude that the 5-methyl group of grepafloxacin favors gyrase in S. pneumoniae.

  5. Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

    PubMed

    Azoulay-Dupuis, E; Bédos, J P; Mohler, J; Peytavin, G; Isturiz, R; Moine, P; Rieux, V; Cherbuliez, C; Péchère, J C; Fantin, B; Köhler, T

    2004-03-01

    Garenoxacin is a novel des-F(6) quinolone with enhanced in vitro activities against both gram-positive and gram-negative bacteria. We compared the activity of garenoxacin with that of trovafloxacin (TVA) against Streptococcus pneumoniae, together with their efficacies and their capacities to select for resistant mutants, in a mouse model of acute pneumonia. In vitro, garenoxacin was more potent than TVA against wild-type S. pneumoniae and against a mutant with a single mutation (parC), a mutant with double mutations (gyrA and parC), and a mutant with triple mutations (gyrA, parC, and parE). Swiss mice were infected with 10(5) CFU of virulent, encapsulated S. pneumoniae strain P-4241 or its derived isogenic parC, gyrA, gyrA parC, and efflux mutants and 10(7) CFU of poorly virulent clinical strains carrying a parE mutation or gyrA, parC, and parE mutations. The drugs were administered six times, every 12 h, beginning at either 3 or 18 h postinfection. The pulmonary pharmacokinetic parameters in mice infected with strain P-4241 and treated with garenoxacin or TVA (25 mg/kg of body weight) were as follows: maximum concentration of drug in serum (C(max); 17.3 and 21.2 micro g/ml, respectively), C(max)/MIC ratio (288 and 170, respectively), area under the concentration-time curve (AUC; 48.5 and 250 microg. h/ml, respectively), and AUC/MIC ratio (808 and 2000, respectively). Garenoxacin at 25 and 50 mg/kg was highly effective (survival rates, 85 to 100%) against the wild-type strain and mutants harboring a single mutation. TVA was as effective as garenoxacin against these strains. TVA at 200 mg/kg and garenoxacin at 50 mg/kg were ineffective against the mutant with the parC and gyrA double mutations and the mutant with the gyrA, parC, and parE triple mutations. The efficacy of garenoxacin was reduced only when strains bore several mutations for quinolone resistance.

  6. Genetic Characterization of Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Isolated during Ciprofloxacin Therapy from a Patient with Bronchiectasis

    PubMed Central

    de la Campa, Adela G.; Ferrandiz, María-José; Tubau, Fe; Pallarés, Román; Manresa, Federico; Liñares, Josefina

    2003-01-01

    Five Spain9V-3 Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants. PMID:12654682

  7. The determination of residence times in a pilot plant

    NASA Astrophysics Data System (ADS)

    Ramírez, F. Pablo; Cortés, M. Eugenia

    2004-01-01

    It is well known that residence time distributions (RTD) are very important in many chemical processes such as separation, reforming, hydrocracking, fluid catalytic cracking, hydrodesulfuration, hydrogenation among others [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. In addition, tracers can be used to measure the velocity, distribution and residence time of any stream through any part of an industrial [Guidebook on Radioisotope Tracers in Industry, IAEA, Vienna, 1990] or experimental system. Perhaps the best quality of radiotracers is that they do not interfere with normal unit operations or production scheduling. In this paper are presented the RTDs obtained in a pilot plant for a hydrogenation process [IMP, Technical Report, Determinación del tiempo de residencia promedio en el reactor de la planta piloto de hidroagotamiento de crudo, 2002]. The RTDs show a random phenomenon, which is not typical of this type of chemical processes. Several RTDs were determined in order to confirm this random behavior. The data were obtained using as a tracer a radioactive form of sodium iodide containing iodine-131 [The Condensed Chemical Dictionary, 10th Ed., Van Nostrand Reinhold, USA, 1981]. The process works with two phases in a countercurrent flow, inside a packed column. The liquid phase goes down by gravity. The gas phase goes up due to pressure difference [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. The tracer was selected such that it would follow the liquid phase.

  8. 31 CFR Appendix B to Part 356 - Formulas and Tables

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CPIDate = reference CPI for the maturity date of the interest component AV = adjusted value of the interest component PA = payment amount at maturity by Treasury Formulas: AV = Par(C/2)(100/Ref CPIIssueDate) (rounded to 2 decimals with no intermediate rounding) PA = AV(Ref CPIDate/100) (rounded to 2 decimals...

  9. Contribution of mutations in DNA gyrase and topoisomerase IV genes to ciprofloxacin resistance in Escherichia coli clinical isolates.

    PubMed

    Bansal, Sandhya; Tandon, Vibha

    2011-03-01

    DNA gyrase (GyrA and GyrB) and topoisomerase IV (ParC and ParE) are the two essential type II topoisomerases in Escherichia coli. These enzymes act via inhibition of DNA replication. Mutations in the quinolone resistance-determining region (QRDR) of the gyrA, gyrB, parC and parE genes from clinical isolates of E. coli were determined by DNA sequencing of 54 ciprofloxacin-resistant clinical isolates from a hospital in Delhi, India. The majority of the E. coli isolates were shown to carry mutations in gyrA, parC and parE. Ciprofloxacin resistance due to accumulation of such a high number of mutations in the QRDR regions of gyrA at positions Ser83 and Asp87 and parC at position Ser80 as well as outside of the QRDR region of parE at Ser458 and Glu460 confers high-level resistance of ciprofloxacin in clinical isolates. The high frequency of occurrence of mutations in the parE gene (44.4% strains) is alarming, as topoisomerase IV is a secondary target of quinolones.

  10. Electronic Paper Turns the Page.

    ERIC Educational Resources Information Center

    Mann, Charles C.

    2001-01-01

    Suggests that, rather than the electronic book, the technology that is most likely to transform reading and writing will be electronic paper (e-paper). Traces the evolution of e-paper from its prototype created by Xerox PARC's Nick Sheridon in 1975 to the E Ink/Lucent e-paper made from e-ink and plastic transistors. Highlights future…

  11. European Research and Development in Hybrid Flexible Electronics

    DTIC Science & Technology

    2010-07-01

    AFOSR), Army Research Office (ARO), Defense Advanced Research Projects Agency ( DARPA ), the Departments of Energy and Commerce, National Aeronautics...principal investigator for PARC’s DARPA sensor-tape program. She came to PARC from Plastic Logic in Cambridge, UK, where she led the semiconductor

  12. Vegetative endocarditis in a scimitar-horned oryx (Oryx dammah).

    PubMed

    Chai, N

    1999-12-01

    Streptococcus uberis was cultured from vegetative endocarditis lesions in a scimitar-horned oryx (Oryx dammah) from the Parc de la Haute Touche, France. This is the first reported single isolation of S. uberis from an oryx with vegetative endocarditis leading to fatal congestive heart failure.

  13. In vitro antimicrobial susceptibility of Alloscardovia omnicolens and molecular mechanisms of acquired resistance.

    PubMed

    Isnard, Christophe; Lienhard, Reto; Reissier, Sophie; Rodriguez, Sonia; Krähenbühl, Joanna; Liassine, Nadia; Guérin, François; Cattoir, Vincent

    2016-03-01

    All the 31 isolates of Alloscardovia omnicolens exhibited low MICs for β-lactams, glycopeptides, linezolid, tetracyclines, and cotrimoxazole. One strain showed MICs ≥256μg/mL for both erythromycin and clindamycin with a single point mutation in 23S rRNA. One strain likely had acquired fluoroquinolone resistance associated with a unique mutation in ParC.

  14. Disease management index of potential years of life lost as a tool for setting priorities in national disease control using OECD health data.

    PubMed

    Jang, Sung-In; Nam, Jung-Mo; Choi, Jongwon; Park, Eun-Cheol

    2014-03-01

    Limited healthcare resources make it necessary to maximize efficiency in disease management at the country level by priority-setting according to disease burden. To make the best priority settings, it is necessary to measure health status and have standards for its judgment, as well as consider disease management trends among nations. We used 17 International Classification of Diseases (ICD) categories of potential years of life lost (YPLL) from Organization for Economic Co-operation and Development (OECD) health data for 2012, 37 disease diagnoses YPLL from OECD health data for 2009 across 22 countries and disability-adjusted life years (DALY) from the World Health Organization (WHO). We set a range of 1-1 for each YPLL per disease in a nation (position value for relative comparison, PARC). Changes over 5 years were also accounted for in this disease management index (disease management index, DMI). In terms of ICD categories, the DMI indicated specific areas for priority setting for different countries with regard to managing disease treatment and diagnosis. Our study suggests that DMI is a realistic index that reflects trend changes over the past 5 years to the present state, and PARC is an easy index for identifying relative status. Moreover, unlike existing indices, DMI and PARC make it easy to conduct multiple comparisons among countries and diseases. DMI and PARC are therefore useful tools for policy implications and for future studies incorporating them and other existing indexes.

  15. Scales of Hydrogen-Bonding Workshop Held in London, England on 1-3 July 1987

    DTIC Science & Technology

    1987-07-03

    UNDERSTANDING OF THE HYDROGEN-BOND INTERACTION Pierre-Charles Maria and Jean-Francois Gal Laboratoire de Chimie Physique Organique , Universite de Nice - Parc...Faculte des Sciences 2 Rue de Ia Houssiniere 44072 Nantes cedex 03 FRANCE Dr Pierre-Charles Maria Laboratorie de Chimie Physique Organic Dr Jean

  16. Contribution of topoisomerase IV mutation to quinolone resistance in Mycoplasma genitalium.

    PubMed

    Yamaguchi, Yuko; Takei, Masaya; Kishii, Ryuta; Yasuda, Mitsuru; Deguchi, Takashi

    2013-04-01

    The mechanism of quinolone resistance in Mycoplasma genitalium remains poorly understood due to difficulties with in vitro culture, especially of clinical isolates. In this study, to confirm the association between mutations in topoisomerases and antimicrobial susceptibilities to quinolones, ciprofloxacin-resistant mutant strains were selected using the cultivable type strain ATCC 33530. Sequence analysis revealed that the mutant strains harbored mutations in topoisomerase IV: Gly81Cys in ParC, Pro261Thr in ParC, or Asn466Lys in ParE. The MICs of all quinolones tested against the mutant strains were 2- to 16-fold higher than those against the wild-type strain. No cross-resistance was observed with macrolides or tetracyclines. We determined the inhibitory activities of quinolones against DNA gyrase and topoisomerase IV in order to investigate the correlation between antimicrobial susceptibility and inhibitory activity against the target enzymes, considered the primary targets of quinolones. Furthermore, using enzymatic analysis, we confirmed that Gly81Cys in the ParC quinolone resistance-determining region (QRDR) contributed to quinolone resistance. This is the first study to isolate quinolone-resistant mutant strains of M. genitalium harboring substitutions in the parC or parE gene in vitro and to measure the inhibitory activities against the purified topoisomerases of M. genitalium.

  17. 'Stolo' Strawberry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ‘Stolo’ is a new June-bearing strawberry (Fragaria x ananassa Duchesne ex Rozier) cultivar from the Agriculture and Agri-Food Canada (AAFC), Pacific Agri-Food Research Center (PARC) in Agassiz, released in cooperation with the B.C. Ministry of Agriculture, Fisheries and Food, U.S. Department of Agri...

  18. Biological Detector Performance with a 402 nm Laser Diode

    DTIC Science & Technology

    2001-07-01

    conventionnelle des spores r6v&le trts peu leur contenu cellulaire . Par contre, les cellules v6g6tatives sont des meilleurs sujets A examen parce qu’elles peuvent...spores of Bacillus subtilis var niger, BG) was accomplished with a Hudson nebulizer (model 1700, Hudson Oxygen Therapy Sales Co.,Wadsworth, OH) driven

  19. CHALLENGES FACING HIGH POWER PROTON ACCELERATORS

    SciTech Connect

    Plum, Michael A

    2013-01-01

    This presentation will provide an overview of the challenges of high power proton accelerators such as SNS, J-PARC, etc., and what we have learned from recent experiences. Beam loss mechanisms and methods to mitigate beam loss will also be discussed.

  20. High Power Proton Facilities

    NASA Astrophysics Data System (ADS)

    Nagaitsev, Sergei

    2015-04-01

    This presentation will provide an overview of the capabilities and challenges of high intensity proton accelerators, such as J-PARC, Fermilab MI, SNS, ISIS, PSI, ESS (in the future) and others. The presentation will focus on lessons learned, new concepts, beam loss mechanisms and methods to mitigate them.

  1. Hadron Structure with Dimuon Production

    SciTech Connect

    Peng, J. C.

    2008-10-13

    Dimuon production has been studied in a series of fixed-target experiments at Fermilab during the last two decades. Highlights from these experiments, together wih recent results from the Fermilab E866 experiment, are presented. Future prospects for studying the parton distributions in the nucleons and nuclei using dimuon production at Fermilab and J-PARC are also discussed.

  2. Increasingly automated procedure acquisition in dynamic systems

    NASA Technical Reports Server (NTRS)

    Mathe, Nathalie; Kedar, Smadar

    1992-01-01

    Procedures are widely used by operators for controlling complex dynamic systems. Currently, most development of such procedures is done manually, consuming a large amount of paper, time, and manpower in the process. While automated knowledge acquisition is an active field of research, not much attention has been paid to the problem of computer-assisted acquisition and refinement of complex procedures for dynamic systems. The Procedure Acquisition for Reactive Control Assistant (PARC), which is designed to assist users in more systematically and automatically encoding and refining complex procedures. PARC is able to elicit knowledge interactively from the user during operation of the dynamic system. We categorize procedure refinement into two stages: diagnosis - diagnose the failure and choose a repair - and repair - plan and perform the repair. The basic approach taken in PARC is to assist the user in all steps of this process by providing increased levels of assistance with layered tools. We illustrate the operation of PARC in refining procedures for the control of a robot arm.

  3. Technology development for laser-cooled clocks on the International Space Station

    NASA Technical Reports Server (NTRS)

    Klipstein, W. M.

    2003-01-01

    The PARCS experiment will use a laser-cooled cesium atomic clock operating in the microgravity environment aboard the International Space Station to provide both advanced tests of gravitational theory to demonstrate a new cold-atom clock technology for space.

  4. Veterinary Research Manpower Development for Defense

    DTIC Science & Technology

    2008-09-01

    seroprevalence of antibodies to ABLV in the Rhinolophus megaphyllus species, we captured and sampled 60 specimens from Comet Mine in Queensland , Australia...completed in the Parc National des Volcans and the MGVP orphan gorilla facility in Kinigi, Rwanda. Subjects will include the orphans at the MGVP center

  5. Molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis clinical isolates.

    PubMed

    Meng, Dong-Ya; Sun, Chang-Jian; Yu, Jing-Bo; Ma, Jun; Xue, Wen-Cheng

    2014-01-01

    To evaluate the molecular mechanism of fluoroquinolones resistance in Mycoplasma hominis (MH) clinical strains isolated from urogenital specimens. 15 MH clinical isolates with different phenotypes of resistance to fluoroquinolones antibiotics were screened for mutations in the quinolone resistance-determining regions (QRDRs) of DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC and parE) in comparison with the reference strain PG21, which is susceptible to fluoroquinolones antibiotics. 15 MH isolates with three kinds of quinolone resistance phenotypes were obtained. Thirteen out of these quinolone-resistant isolates were found to carry nucleotide substitutions in either gyrA or parC. There were no alterations in gyrB and no mutations were found in the isolates with a phenotype of resistance to Ofloxacin (OFX), intermediate resistant to Levofloxacin (LVX) and Sparfloxacin (SFX), and those susceptible to all three tested antibiotics. The molecular mechanism of fluoroquinolone resistance in clinical isolates of MH was reported in this study. The single amino acid mutation in ParC of MH may relate to the resistance to OFX and LVX and the high-level resistance to fluoroquinolones for MH is likely associated with mutations in both DNA gyrase and the ParC subunit of topoisomerase IV.

  6. Incomplete Contract Files for Southwest Asia Task Orders on the Warfighter Field Operations Customer Support Contract

    DTIC Science & Technology

    2011-06-01

    Multipurpose Wheeled Vehicle ITAM Iraq Training Advisory Mission MRAP Mine Resistant Ambush Protected PARC Principal Assistant Responsible for...million of training services placed on task order 022; and • Iraq Training and Advisory Mission ( ITAM ) training effort, valued at approximately $66.9...MRAP expedient armor program training effort. ITAM Training Effort PEO STRI contracting personnel awarded the ITAM training effort on the

  7. An electrochemical method for determining hydrogen concentrations in metals and some applications

    NASA Technical Reports Server (NTRS)

    Danford, M. D.

    1983-01-01

    An electrochemical method was developed for the determination of hydrogen in metals using the EG&G-PARC Model 350A Corrosion Measurement Console. The method was applied to hydrogen uptake, both during electrolysis and electroplating, and to studies of hydrogen elimination and the effect of heat treatment on elimination times. Results from these studies are presented.

  8. Two-dimensional viscous flow computations of hypersonic scramjet nozzle flowfields at design and off-design conditions

    NASA Technical Reports Server (NTRS)

    Harloff, G. J.; Lai, H. T.; Nelson, E. S.

    1988-01-01

    The PARC2D code has been selected to analyze the flowfields of a representative hypersonic scramjet nozzle over a range of flight conditions from Mach 3 to 20. The flowfields, wall pressures, wall skin friction values, heat transfer values and overall nozzle performance are presented.

  9. COMET and PRISM - Search for Charged Lepton Flavor Violation with Muons

    NASA Astrophysics Data System (ADS)

    Kuno, Yoshitaka

    2012-04-01

    The experiment (COMET) at J-PARC to search for a charged-lepton-flavor-violating process of muon to electron conversion in a muonic atom is described. Future prospects of an experiment (PRISM) with even higher sensitivity is mentioned. On-going R&D on a highly intense muon source (MuSIC) at Osaka University is presented.

  10. Electronic Warfare and Radar Systems Engineering Handbook

    DTIC Science & Technology

    2012-06-01

    typically are of the Stirling cycle design and utilize the expansion of a gas (helium) to cool a cold finger attached to the detector. These generally...PARC). The two primary inventors were Robert Metcalf and David Boggs. IEEE Project 802 was set up in February 1980 to provide standards for

  11. Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and β-Lactams in Acinetobacter Genospecies 3

    PubMed Central

    Ribera, A.; Fernández-Cuenca, F.; Beceiro, A.; Bou, G.; Martínez-Martínez, L.; Pascual, A.; Cisneros, J. M.; Rodríguez-Baño, J.; Pachón, J.; Vila, J.

    2004-01-01

    Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies 3. Moreover, the mechanisms of resistance to some β-lactam antibiotics may be associated with the presence of a chromosomal cephalosporinase, AmpC, and the resistance to quinolones related to mutations in the gyrA and parC genes. PMID:15047561

  12. In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone

    PubMed Central

    Roychoudhury, Siddhartha; Makin, Kelly; Twinem, Tracy; Leunk, Robert

    2016-01-01

    Selection of resistant strains in Streptococcus pneumoniae was studied in vitro with nemonoxacin, a novel nonfluorinated quinolone (NFQ), in comparison with quinolone benchmarks, ciprofloxacin, garenoxacin, and gatifloxacin. In stepwise resistance selection studies, a 256-fold loss of potency was observed after three to four steps of exposure to ciprofloxacin or garenoxacin. In contrast, the loss of potency was limited to eightfold after three steps of exposure to nemonoxacin and repeated attempts to isolate highly resistant organisms after four steps of exposure yielded isolates that could not be subcultured in liquid medium. The quinolone resistance-determining regions of the target genes, parC, parE, gyrA, and gyrB, were analyzed through DNA sequencing. Known mutations, especially in the hotspots of parC and gyrA, were selected with exposure to garenoxacin, ciprofloxacin, and gatifloxacin. In contrast, mutations selected with nemonoxacin were limited to GyrA, GyrB, and ParE, sparing ParC, which is known as a key driver of resistance in clinical isolates of S. pneumoniae. This observation is consistent with previous data using other NFQs, which showed no loss of potency due to ParC mutations in clinical isolates. This apparently unique feature of nemonoxacin is potentially attributable to the structural uniqueness of the NFQs, distinguishing them from the fluoroquinolones that are commonly prescribed for infections by S. pneumoniae. PMID:27267788

  13. Plenary.

    ERIC Educational Resources Information Center

    Brown, John Seely

    2000-01-01

    Presents a biography of John Seely Brown, chief scientist of Xerox Corporation and the director of its Palo Alto Research Center (PARC). Interests include formation of corporate strategy; corporate research, including organizational learning, ethnographies of the workplace, and complex adaptive systems; and human learning and the management of…

  14. Genetic characterization of fluoroquinolone-resistant Escherichia coli associated with bovine mastitis in India

    PubMed Central

    Balakrishnan, Sangeetha; Antony, Prabhakar Xavier; Mukhopadhyay, Hirak Kumar; Pillai, Raghavan Madhusoodanan; Thanislass, Jacob; Padmanaban, Vijayalakshmi; Srinivas, Mouttou Vivek

    2016-01-01

    Aim: The present study was undertaken to characterize the mutation in gyrA (DNA gyrase) and parC (topoisomerase IV) genes responsible for fluoroquinolone resistance in Escherichia coli isolates associated with the bovine mastitis. Materials and Methods: A total of 92 milk samples from bovine mastitis cases were sampled in and around Puducherry (Southern India). Among these samples, 30 isolates were bacteriologically characterized as E. coli. Minimum inhibitory concentrations (MIC) of fluoroquinolones of these 30 E. coli isolates were evaluated by resazurin microtiter assay. Then, the quinolone resistance determining region (QRDR) (gyrA and parC genes) of these E. coli isolates was genetically analyzed for determining the chromosomal mutation causing fluoroquinolone resistance. Results: E. coli isolates showed a resistance rate of 63.33%, 23.33% and 30.03% to nalidixic acid, ciprofloxacin and enrofloxacin, respectively. Mutations were found at 83rd and 87th amino acid position of gyrA gene, and at 80th and 108th amino acid position of parC gene in our study isolates. Among these five isolates, one had a single mutation at 83 amino acid position of gyrA with reduced susceptibility (0.5 µg/ml) to ciprofloxacin. Then, in remaining four isolates, three isolates showed triple mutation (at gyrA: S83⟶L and D87⟶N; at parC: S80⟶I) and the fifth isolate showed an additional mutation at codon 108 of parC (A108⟶T) with the increased ciprofloxacin MIC of 16-128 µg/ml. The most common mutation noticed were at S83⟶L and D87⟶N of gyrA and S80⟶I of ParC. Conclusion: The study confirms the presence of mutation/s responsible for fluoroquinolone resistance in QRDR of gyrA and parC genes of E. coli isolates of animal origin, and there is increased rate of fluoroquinolone resistance with high-level of MIC. The mutations observed in this study were similar to that of human isolates. PMID:27536030

  15. Analysis of an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1992-01-01

    A time marching Navier-Stokes code called PARC (PARC2D for 2-D/axisymmetric and PARC3D for 3-D flow simulations) was validated for an advanced ducted propeller (ADP) subsonic inlet. The code validation for an advanced ducted propeller (ADP) subsonic inlet. The code validation was implemented for a non-separated flow condition associated with the inlet operating at angles-of-attack of 0 and 25 degrees. The inlet test data were obtained in the 9 x 15 ft Low Speed Wind Tunnel at NASA Lewis Research Center as part of a cooperative study with Pratt and Whitney. The experimental study focused on the ADP inlet performance for take-off and approach conditions. The inlet was tested at a free stream Mach number of 0.2, at angles-of-attack between O and 35 degrees, and at a maximum propeller speed of 12,000 RPM which induced a corrected air flow rate of about 46 lb/sec based on standard day conditions. The computational grid and flow boundary conditions (BC) were based on the actual inlet geometry and the funnel flow conditions. At the propeller face, two types of BC's were applied: a mass flow BC and a fixed flow properties BC. The fixed flow properties BC was based on a combination of data obtained from the experiment and calculations using a potential flow code. Comparison of the computational results with the test data indicates that the PARC code with the propeller face fixed flow properties BC provided a better prediction of the inlet surface static pressures than the predictions when the mass flow BC was used. For an angle-of-attack of 0 degrees, the PARC2D code with the propeller face mass flow BC provided a good prediction of inlet static pressures except in the region of high pressure gradient. With the propeller face fixed flow properties BC, the PARC2D code provided a good prediction of the inlet static pressures. For an angle-of-attack of 25 degrees with the mass flow BC, the PARC3D code predicted statis pressures which deviated significantly from the test data

  16. Internally directed cognition and mindfulness: an integrative perspective derived from predictive and reactive control systems theory

    PubMed Central

    Tops, Mattie; Boksem, Maarten A. S.; Quirin, Markus; IJzerman, Hans; Koole, Sander L.

    2013-01-01

    In the present paper, we will apply the predictive and reactive control systems (PARCS) theory as a framework that integrates competing theories of neural substrates of awareness by describing the “default mode network” (DMN) and anterior insula (AI) as parts of two different behavioral and homeostatic control systems. The DMN, a network that becomes active at rest when there is no external stimulation or task to perform, has been implicated in self-reflective awareness and prospection. By contrast, the AI is associated with awareness and task-related attention. This has led to competing theories stressing the role of the DMN in self-awareness vs. the role of interoceptive and emotional information integration in the AI in awareness of the emotional moment. In PARCS, the respective functions of the DMN and AI in a specific control system explains their association with different qualities of awareness, and how mental states can shift from one state (e.g., prospective self-reflection) to the other (e.g., awareness of the emotional moment) depending on the relative dominance of control systems. These shifts between reactive and predictive control are part of processes that enable the intake of novel information, integration of this novel information within existing knowledge structures, and the creation of a continuous personal context in which novel information can be integrated and understood. As such, PARCS can explain key characteristics of mental states, such as their temporal and spatial focus (e.g., a focus on the here and now vs. the future; a first person vs. a third person perspective). PARCS further relates mental states to brain states and functions, such as activation of the DMN or hemispheric asymmetry in frontal cortical functions. Together, PARCS deepens the understanding of a broad range of mental states, including mindfulness, mind wandering, rumination, autobiographical memory, imagery, and the experience of self. PMID:24904455

  17. Activity of gemifloxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

    PubMed

    Azoulay-Dupuis, E; Bédos, J P; Mohler, J; Moine, P; Cherbuliez, C; Peytavin, G; Fantin, B; Köhler, T

    2005-03-01

    Gemifloxacin is a novel fluoronaphthyridone quinolone with enhanced in vitro activity against Streptococcus pneumoniae. We investigated the activities of gemifloxacin and trovafloxacin, their abilities to select for resistance in vitro and in vivo, and their efficacies in a mouse model of acute pneumonia. Immunocompetent Swiss mice were infected with 10(5) CFU of a virulent, encapsulated S. pneumoniae strain, P-4241, or its isogenic parC, gyrA, parC gyrA, and efflux mutant derivatives (serotype 3); and leukopenic mice were infected with 10(7) CFU of two poorly virulent clinical strains (serotype 11A) carrying either a parE mutation or a parC, gyrA, and parE triple mutation. The drugs were administered six times every 12 h, starting at either 3 or 18 h postinfection. In vitro, gemifloxacin was the most potent agent against strains with and without acquired resistance to fluoroquinolones. While control mice died within 6 days, gemifloxacin at doses of 25 and 50 mg/kg of body weight was highly effective (survival rates, 90 to 100%) against the wild-type strain and against mutants harboring a single mutation, corresponding to area under the time-versus-serum concentration curve at 24 h (AUC(24))/MIC ratios of 56.5 to 113, and provided a 40% survival rate against a mutant with a double mutation (parC and gyrA). A total AUC(24)/MIC ratio of 28.5 was associated with poor efficacy and the emergence of resistant mutants. Trovafloxacin was as effective as gemifloxacin against mutants with single mutations but did not provide any protection against the mutant with double mutations, despite treatment with a high dose of 200 mg/kg. Gemifloxacin preferentially selected for parC mutants both in vitro and in vivo.

  18. The T2K experiment

    NASA Astrophysics Data System (ADS)

    Abe, K.; Abgrall, N.; Aihara, H.; Ajima, Y.; Albert, J. B.; Allan, D.; Amaudruz, P.-A.; Andreopoulos, C.; Andrieu, B.; Anerella, M. D.; Angelsen, C.; Aoki, S.; Araoka, O.; Argyriades, J.; Ariga, A.; Ariga, T.; Assylbekov, S.; de André, J. P. A. M.; Autiero, D.; Badertscher, A.; Ballester, O.; Barbi, M.; Barker, G. J.; Baron, P.; Barr, G.; Bartoszek, L.; Batkiewicz, M.; Bay, F.; Bentham, S.; Berardi, V.; Berger, B. E.; Berns, H.; Bertram, I.; Besnier, M.; Beucher, J.; Beznosko, D.; Bhadra, S.; Birney, P.; Bishop, D.; Blackmore, E.; Blaszczyk, F. d. M.; Blocki, J.; Blondel, A.; Bodek, A.; Bojechko, C.; Bouchez, J.; Boussuge, T.; Boyd, S. B.; Boyer, M.; Braam, N.; Bradford, R.; Bravar, A.; Briggs, K.; Brinson, J. D.; Bronner, C.; Brook-Roberge, D. G.; Bryant, M.; Buchanan, N.; Budd, H.; Cadabeschi, M.; Calland, R. G.; Calvet, D.; Caravaca Rodríguez, J.; Carroll, J.; Cartwright, S. L.; Carver, A.; Castillo, R.; Catanesi, M. G.; Cavata, C.; Cazes, A.; Cervera, A.; Charrier, J. P.; Chavez, C.; Choi, S.; Chollet, S.; Christodoulou, G.; Colas, P.; Coleman, J.; Coleman, W.; Collazuol, G.; Connolly, K.; Cooke, P.; Curioni, A.; Dabrowska, A.; Danko, I.; Das, R.; Davies, G. S.; Davis, S.; Day, M.; De La Broise, X.; de Perio, P.; De Rosa, G.; Dealtry, T.; Debraine, A.; Delagnes, E.; Delbart, A.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Dinh Tran, P.; Dobson, J.; Doornbos, J.; Dore, U.; Drapier, O.; Druillole, F.; Dufour, F.; Dumarchez, J.; Durkin, T.; Dytman, S.; Dziewiecki, M.; Dziomba, M.; Ellison, B.; Emery, S.; Ereditato, A.; Escallier, J. E.; Escudero, L.; Esposito, L. S.; Faszer, W.; Fechner, M.; Ferrero, A.; Finch, A.; Fisher, C.; Fitton, M.; Flight, R.; Forbush, D.; Frank, E.; Fransham, K.; Fujii, Y.; Fukuda, Y.; Gallop, M.; Galymov, V.; Ganetis, G. L.; Gannaway, F. C.; Gaudin, A.; Gaweda, J.; Gendotti, A.; George, M.; Giffin, S.; Giganti, C.; Gilje, K.; Giomataris, I.; Giraud, J.; Ghosh, A. K.; Golan, T.; Goldhaber, M.; Gomez-Cadenas, J. J.; Gomi, S.; Gonin, M.; Goyette, M.; Grant, A.; Grant, N.; Grañena, F.; Greenwood, S.; Gumplinger, P.; Guzowski, P.; Haigh, M. D.; Hamano, K.; Hansen, C.; Hara, T.; Harrison, P. F.; Hartfiel, B.; Hartz, M.; Haruyama, T.; Hasanen, R.; Hasegawa, T.; Hastings, N. C.; Hastings, S.; Hatzikoutelis, A.; Hayashi, K.; Hayato, Y.; Haycock, T. D. J.; Hearty, C.; Helmer, R. L.; Henderson, R.; Herlant, S.; Higashi, N.; Hignight, J.; Hiraide, K.; Hirose, E.; Holeczek, J.; Honkanen, N.; Horikawa, S.; Hyndman, A.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Iida, M.; Ikeda, M.; Ilic, J.; Imber, J.; Ishida, T.; Ishihara, C.; Ishii, T.; Ives, S. J.; Iwasaki, M.; Iyogi, K.; Izmaylov, A.; Jamieson, B.; Johnson, R. A.; Joo, K. K.; Jover-Manas, G.; Jung, C. K.; Kaji, H.; Kajita, T.; Kakuno, H.; Kameda, J.; Kaneyuki, K.; Karlen, D.; Kasami, K.; Kasey, V.; Kato, I.; Kawamuko, H.; Kearns, E.; Kellet, L.; Khabibullin, M.; Khaleeq, M.; Khan, N.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kim, J. Y.; Kim, S.-B.; Kimura, N.; Kirby, B.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Kogan, G.; Koike, S.; Komorowski, T.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kouzuma, Y.; Kowalik, K.; Kravtsov, V.; Kreslo, I.; Kropp, W.; Kubo, H.; Kubota, J.; Kudenko, Y.; Kulkarni, N.; Kurchaninov, L.; Kurimoto, Y.; Kurjata, R.; Kurosawa, Y.; Kutter, T.; Lagoda, J.; Laihem, K.; Langstaff, R.; Laveder, M.; Lawson, T. B.; Le, P. T.; Le Coguie, A.; Le Ross, M.; Lee, K. P.; Lenckowski, M.; Licciardi, C.; Lim, I. T.; Lindner, T.; Litchfield, R. P.; Longhin, A.; Lopez, G. D.; Lu, P.; Ludovici, L.; Lux, T.; Macaire, M.; Magaletti, L.; Mahn, K.; Makida, Y.; Malafis, C. J.; Malek, M.; Manly, S.; Marchionni, A.; Mark, C.; Marino, A. D.; Marone, A. J.; Marteau, J.; Martin, J. F.; Maruyama, T.; Maryon, T.; Marzec, J.; Masliah, P.; Mathie, E. L.; Matsumura, C.; Matsuoka, K.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCauley, N.; McFarland, K. S.; McGrew, C.; McLachlan, T.; Mercer, I.; Messina, M.; Metcalf, W.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Minvielle, R. E.; Mituka, G.; Miura, M.; Mizouchi, K.; Mols, J.-P.; Monfregola, L.; Monmarthe, E.; Moreau, F.; Morgan, B.; Moriyama, S.; Morris, D.; Muir, A.; Murakami, A.; Muratore, J. F.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagashima, G.; Nakadaira, T.; Nakahata, M.; Nakamoto, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Naples, D.; Nelson, B.; Nicholls, T. C.; Nishikawa, K.; Nishino, H.; Nitta, K.; Nizery, F.; Nowak, J. A.; Noy, M.; Obayashi, Y.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Okumura, K.; Okusawa, T.; Ohlmann, C.; Olchanski, K.; Openshaw, R.; Oser, S. M.; Otani, M.; Owen, R. A.; Oyama, Y.; Ozaki, T.; Pac, M. Y.; Palladino, V.; Paolone, V.; Paul, P.; Payne, D.; Pearce, G. F.; Pearson, C.; Perkin, J. D.; Pfleger, M.; Pierre, F.; Pierrepont, D.; Plonski, P.; Poffenberger, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Preece, R.; Przewlocki, P.; Qian, W.; Raaf, J. L.; Radicioni, E.; Ramos, K.; Ratoff, P.; Raufer, T. M.; Ravonel, M.; Raymond, M.; Retiere, F.; Richards, D.; Ritou, J.-L.; Robert, A.; Rodrigues, P. A.; Rondio, E.; Roney, M.; Rooney, M.; Ross, D.; Rossi, B.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sadler, S.; Sakashita, K.; Sanchez, F.; Sarrat, A.; Sasaki, K.; Schaack, P.; Schmidt, J.; Scholberg, K.; Schwehr, J.; Scott, M.; Scully, D. I.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sheffer, G.; Shibata, M.; Shimizu, Y.; Shiozawa, M.; Short, S.; Siyad, M.; Smith, D.; Smith, R. J.; Smy, M.; Sobczyk, J.; Sobel, H.; Sooriyakumaran, S.; Sorel, M.; Spitz, J.; Stahl, A.; Stamoulis, P.; Star, O.; Statter, J.; Stawnyczy, L.; Steinmann, J.; Steffens, J.; Still, B.; Stodulski, M.; Stone, J.; Strabel, C.; Strauss, T.; Sulej, R.; Sutcliffe, P.; Suzuki, A.; Suzuki, K.; Suzuki, S.; Suzuki, S. Y.; Suzuki, Y.; Suzuki, Y.; Swierblewski, J.; Szeglowski, T.; Szeptycka, M.; Tacik, R.; Tada, M.; Tadepalli, A. S.; Taguchi, M.; Takahashi, S.; Takeda, A.; Takenaga, Y.; Takeuchi, Y.; Tanaka, H. A.; Tanaka, K.; Tanaka, M.; Tanaka, M. M.; Tanimoto, N.; Tashiro, K.; Taylor, I. J.; Terashima, A.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Thorpe, M.; Toki, W.; Tomaru, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tvaskis, V.; Tzanov, M.; Uchida, Y.; Ueno, K.; Usseglio, M.; Vacheret, A.; Vagins, M.; Van Schalkwyk, J. F.; Vanel, J.-C.; Vasseur, G.; Veledar, O.; Vincent, P.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wanderer, P. J.; Ward, M. A.; Ward, G. P.; Wark, D.; Warner, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wendland, J.; West, N.; Whitehead, L. H.; Wikström, G.; Wilkes, R. J.; Wilking, M. J.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wong, K.; Wongjirad, T.; Yamada, S.; Yamada, Y.; Yamamoto, A.; Yamamoto, K.; Yamanoi, Y.; Yamaoka, H.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Zalewska, A.; Zalipska, J.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Zmuda, J.; T2K Collaboration

    2011-12-01

    The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ13 by observing νe appearance in a νμ beam. It also aims to make a precision measurement of the known oscillation parameters, Δm232 and sin22θ23, via νμ disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem.

  19. Partners in amphibian and reptile conservation 2013 annual report

    USGS Publications Warehouse

    Conrad, Paulette M.; Weir, Linda A.; Nanjappa, Priya

    2014-01-01

    Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effect from overexploitation; these animals are also challenged by the perception that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural an cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation of these animals has never been more important.

  20. Transient Safety Analysis of Fast Spectrum TRU Burning LWRs with Internal Blankets

    SciTech Connect

    Downar, Thomas; Zazimi, Mujid; Hill, Bob

    2015-01-31

    The objective of this proposal was to perform a detailed transient safety analysis of the Resource-Renewable BWR (RBWR) core designs using the U.S. NRC TRACE/PARCS code system. This project involved the same joint team that has performed the RBWR design evaluation for EPRI and therefore be able to leverage that previous work. And because of their extensive experience with fast spectrum reactors and parfait core designs, ANL was also part the project team. The principal outcome of this project was the development of a state-of-the-art transient analysis capability for GEN-IV reactors based on Monte Carlo generated cross sections and the US NRC coupled code system TRACE/PARCS, and a state-of-the-art coupled code assessment of the transient safety performance of the RBWR.

  1. Development and applications of a multi-purpose digital controller with a System-on-Chip FPGA for accelerators

    NASA Astrophysics Data System (ADS)

    Kurimoto, Yoshinori; Nakamura, Keigo

    2016-12-01

    J-PARC Main Ring (MR) is a high intensity proton synchrotron which accelerates protons from 3 GeV to 30 GeV. It has operated at a beam intensity of 390 kW and an upgrade toward the megawatt rating is scheduled. For higher beam intensity, some of the accelerator components require more intelligent and complicated functions. To consolidate such functions among various components, we developed multi-purpose digital boards using a System-on-Chip Field-Programmable Gated Array (SoC FPGA). In this paper, we describe the details of our developed boards as well as their possible applications. As an application of the boards, we have successfully performed the measurement of the betatron amplitude function during beam acceleration in J-PARC MR. The experimental setup and results of the measurement are also described in detail.

  2. High-Precision Microwave Spectroscopy of Muonium for Determination of Muonic Magnetic Moment

    NASA Astrophysics Data System (ADS)

    Torii, H. A.; Higashi, Y.; Higuchi, T.; Matsuda, Y.; Mizutani, T.; Tajima, M.; Tanaka, K. S.; Ueno, Y.; Fukao, Y.; Iinuma, H.; Ikedo, Y.; Kadono, R.; Kawamura, N.; Koda, A.; Kojima, K. M.; Mibe, T.; Miyake, Y.; Nagamine, K.; Nishiyama, K.; Ogitsu, T.; Okubo, R.; Saito, N.; Sasaki, K.; Shimomura, K.; Strasser, P.; Sugano, M.; Toyoda, A.; Ueno, K.; Yamamoto, A.; Yoshida, M.; Ishida, K.; Iwasaki, M.; Kamigaito, O.; Tomono, D.; Kanda, S.; Kubo, K.; Aoki, M.; Torikai, E.; Kawall, D.

    2016-02-01

    The muonium atom is a system suitable for precision measurements for determination of muon’s fundamental properties as well as for the test of quantum electrodynamics (QED). A microwave spectroscopy experiment of this exotic atom is being prepared at J-PARC, jointly operated by KEK and JAEA in Japan, aiming at an improved relative precision at a level of 10-8 in determination of the muonic magnetic moment. A major improvement of statistical uncertainty is expected with the higher muon intensity of the pulsed beam at J-PARC, while reduction of various sources of systematic uncertainties are being studied: those arising from microwave power fluctuations, magnetic field inhomogeneity, muon stopping distribution and atomic collisional shift of resonance frequencies. Experimental strategy and methods are presented in this paper, with an emphasis on our recent development of apparatuses and evaluation of systematic uncertainties.

  3. From the "Phoenix of Legends" to the "Ultimate Monument" of the times: stadia, spectators, and urban development in postwar Paris.

    PubMed

    Lewis, Robert W

    2012-01-01

    This article analyzes the renovation and construction of the Parc des Princes and the Stade de France in post-Second World War Paris. The history of the two stadia testifies to a shift in the envisioned role of stadia in the Parisian basin between the late 1960s and the end of the twentieth century and stands as evidence for the emergence of new urban planning actors. Both stadia were also critiqued as symbols of broader problems with Parisian urbanization, notably as manifestations of anti-democratic planning processes. At the same time, the Parc and the Stade also reflected an emerging consensus over the role of spectator sport in society, accompanied by attempts to re-envision mass sporting spectatorship as a more democratic and familial practice. This article thus situates the two stadia within the history of Parisian urbanization and within broader global urbanizing processes.

  4. La Ruta de los Origenes stops in Montsec: observations and other educational activities

    NASA Astrophysics Data System (ADS)

    Ribas, S. J.

    2013-05-01

    La Ruta de los Origenes is an European Cooperation Project POCTEFA funded by FEDER- UE. The main objective of this project is to establish a touristic route on both sides of the Pyrenees to approach Origins topic to the public. This project is developed by six partners, three in Catalonia and three in Midi-Pyrenees, and is focused in Astronomy, Paleontology and Archaelogy. Montsec mountains are placed in the Pre-Pyrenees area of Lleida province and they are a very good place for astronomy (dark skies, good seeing, good weather conditions). Parc Astronomic Montsec is the major astronomy project in that area and it includes a research astronomical observatory and an outreach and education center. So Montsec mountains and their Parc Astronomic are one of the stops of this route with an important number of activities to approach astronomy to public.

  5. Bird community in a forest patch isolated by the urban matrix at the Sinos River basin, Rio Grande do Sul State, Brazil, with comments on the possible local defaunation.

    PubMed

    Franz, I; Cappelatti, L; Barros, M P

    2010-12-01

    We compared the avifauna recorded in a recent survey in an urban park (Parque Municipal Henrique Luís Roessler, Parcão) and surroundings, Novo Hamburgo, RS, with past data, to evaluate the possible alterations in species composition over time. Of the 265 species compiled as original elements of that region, 114 were found at Parcão. Among forest species, 37% were considered locally extinct. The most affected guild was the large frugivores, with nine extinct species and one survivor (Trogon surrucura). Birds highly sensitive to disturbance as well as endemic species were the most extinguished. The possible causes for this loss are fragmentation, hunting and environmental changes. The diversity today is threatened, thus conservation measures are necessary in that region. The most important actions are: maintenance of ecological corridors, protection of natural remnant areas and the establishment of protected areas.

  6. PAR Analysis of HSR Nozzles

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.

    1999-01-01

    Only recently has computational fluid dynamics (CFD) been relied upon to predict the flow details of advanced nozzle concepts. Computer hardware technology and flow solving techniques are advancing rapidly and CFD is now being used to analyze such complex flows. Validation studies are needed to assess the accuracy, reliability, and cost of such CFD analyses. At NASA Lewis, the PARC2D/3D full Navier-Stokes (FNS) codes are being applied to HSR-type nozzles. This report presents the results of two such PARC FNS analyses. The first is an analysis of the Pratt and Whitney 2D mixer-ejector nozzle, conducted by Dr. Yunho Choi (formerly of Sverdrup Technology-NASA Lewis Group). The second is an analysis of NASA-Langley's axisymmetric single flow plug nozzle, conducted by the author.

  7. QX MAN: Q and X file manipulation

    NASA Technical Reports Server (NTRS)

    Krein, Mark A.

    1992-01-01

    QX MAN is a grid and solution file manipulation program written primarily for the PARC code and the GRIDGEN family of grid generation codes. QX MAN combines many of the features frequently encountered in grid generation, grid refinement, the setting-up of initial conditions, and post processing. QX MAN allows the user to manipulate single block and multi-block grids (and their accompanying solution files) by splitting, concatenating, rotating, translating, re-scaling, and stripping or adding points. In addition, QX MAN can be used to generate an initial solution file for the PARC code. The code was written to provide several formats for input and output in order for it to be useful in a broad spectrum of applications.

  8. TREK: A Search for Time Reversal Symmetry Violation in Charged Kaon Decays

    SciTech Connect

    Kohl, Michael

    2010-08-04

    The Time Reversal Experiment with Kaons (TREK) at J-PARC aims to find New Physics beyond the Standard Model by measuring the T-violating transverse polarization P{sub T} of muons in the K{sub {mu}3}{sup +} decay of stopped kaons. TREK will use a high-intensity kaon beam and the upgraded apparatus of the E-246 experiment from KEK-PS. The sensitivity for P{sub T} of 10{sup -4} at J-PARC is improved by a factor of 20 compared to the current E-246 limit, well in the allowed range of various models involving New Physics from exotic scalar interactions. An overview of the planned experiment and the status of the detector upgrade will be presented.

  9. TREK: A Search for Time Reversal Symmetry Violation in Charged Kaon Decays

    SciTech Connect

    Kohl, Michael

    2010-08-01

    The Time Reversal Experiment with Kaons (TREK) at J-PARC aims to find New Physics beyond the Standard Model by measuring the T-violating transverse polarization PT of muons in the Kµ3+ decay of stopped kaons. TREK will use a high-intensity kaon beam and the upgraded apparatus of the E-246 experiment from KEK-PS. The sensitivity for PT of 10-4 at J-PARC is improved by a factor of 20 compared to the current E-246 limit, well in the allowed range of various models involving New Physics from exotic scalar interactions. An overview of the planned experiment and the status of the detector upgrade will be presented.

  10. Palo Alto Research Center - Smart Embedded Network of Sensors with an Optical Readout

    SciTech Connect

    Raghavan, Ajay; Sahu, Saroj; Bringans, Ross; Johnson, Noble; Kiesel, Peter; Saha, Bhaskar

    2014-03-07

    PARC is developing new fiber optic sensors that would be embedded into batteries to monitor and measure key internal parameters during charge and discharge cycles. Two significant problems with today's best batteries are their lack of internal monitoring capabilities and their design oversizing. The lack of monitoring interferes with the ability to identify and manage performance or safety issues as they arise, which are presently managed by very conservative design oversizing and protection approaches that result in cost inefficiencies. PARC's design combines low-cost, embedded optical battery sensors and smart algorithms to overcome challenges faced by today's best battery management systems. These advanced fiber optic sensing technologies have the potential to dramatically improve the safety, performance, and life-time of energy storage systems.

  11. Modification of the Two-equation Turbulence Model in NPARC to a Chien Low Reynolds Number K-epsilon Formulation

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.; Chitsomboon, Tawit; Zhu, Jiang

    1994-01-01

    This report documents the changes that were made to the two-equation k-epsilon turbulence model in the NPARC (National-PARC) code. The previous model based on the low Reynolds number model of Speziale, was replaced with the low Reynolds number k-epsilon model of Chien. The most significant difference was in the turbulent Prandtl numbers appearing in the diffusion terms of the k and epsilon transport equations. A new inflow boundary condition and stability enhancements were also implemented into the turbulence model within NPARC. The report provides the rationale for making the change to the Chien model, code modifications required, and comparisons of the performances of the new model with the previous k-epsilon model and algebraic models used most often in PARC/NPARC. The comparisons show that the Chien k-epsilon model installed here improves the capability of NPARC to calculate turbulent flows.

  12. Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli

    PubMed Central

    Gomig, Franciane; Galvão, Carolina Weigert; de Freitas, Denis Leandro; Labas, Larissa; Etto, Rafael Mazer; Esmerino, Luiz Antonio; de Lima, Marcelo Andrade; Appel, Marcia Helena; Zanata, Silvio Marques; Steffens, Maria Berenice Reynaud; Nader, Helena Bonciani; da Silveira, Rafael Bertoni

    2015-01-01

    Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that the lack of ornithine decarboxylase (ODC) activity is correlated with quinolone resistance. Despite the low number of isolates examined, this is the first study correlating these characteristics in lactose-negative E. coli isolates. PMID:26413057

  13. Palo Alto Research Center - Smart Embedded Network of Sensors with an Optical Readout

    ScienceCinema

    Raghavan, Ajay; Sahu, Saroj; Bringans, Ross; Johnson, Noble; Kiesel, Peter; Saha, Bhaskar

    2016-07-12

    PARC is developing new fiber optic sensors that would be embedded into batteries to monitor and measure key internal parameters during charge and discharge cycles. Two significant problems with today's best batteries are their lack of internal monitoring capabilities and their design oversizing. The lack of monitoring interferes with the ability to identify and manage performance or safety issues as they arise, which are presently managed by very conservative design oversizing and protection approaches that result in cost inefficiencies. PARC's design combines low-cost, embedded optical battery sensors and smart algorithms to overcome challenges faced by today's best battery management systems. These advanced fiber optic sensing technologies have the potential to dramatically improve the safety, performance, and life-time of energy storage systems.

  14. Sepsis and Inflammatory Response Mechanisms: An Activity Stress Model in Humans

    DTIC Science & Technology

    2001-01-31

    principales caracteristiques de la reaction inflammatoire classique, soit la mobilisation et 1’ activation des granulocytes, des lymphocytes et des...un modele P515436.PDF [Page: 6 of 58] acceptable, voire adequat, pour 1’ etude des reactions inflammatoires sub-cliniques chez l’humain. II reste...Les constatations decoulant de 1 ’experimentation animale sont jugees suspectes parce que la nature et I’ evolution des reactions inflammatoires

  15. High percentage of resistance to ciprofloxacin and qnrB19 gene identified in urinary isolates of extended-spectrum beta-lactamase-producing Escherichia coli in Madrid, Spain.

    PubMed

    Ríos, Esther; Rodríguez-Avial, Iciar; Rodríguez-Avial, Carmen; Hernandez, Elena; Picazo, Juan Jose

    2010-08-01

    The presence of qnr genes in 191 extended-spectrum beta-lactamase-producing Escherichia coli from 2005, with 75% of resistance to ciprofloxacin, was evaluated. An SHV-12-producing E. coli carried qnrB19; both genes were transferred by conjugation. No qnrA- or qnrS-positive strains were detected. In addition, we identified 3 new parC mutations (S80W, E84R, and E84A).

  16. RMS ENVELOPE BACK-PROPAGATION IN THE XAL ONLINE MODEL

    SciTech Connect

    Allen, Christopher K; Sako, Hiroyuki; Ikegami, Masanori

    2009-01-01

    The ability to back-propagate RMS envelopes was added to the J-PARC XAL online model. Specifically, given an arbitrary downstream location, the online model can propagate the RMS envelopes backward to an arbitrary upstream location. This feature provides support for algorithms estimating upstream conditions from downstream data. The upgrade required significant refactoring, which we outline. We also show simulations using the new feature.

  17. Backward charmonium production in π N collisions

    NASA Astrophysics Data System (ADS)

    Pire, B.; Semenov-Tian-Shansky, K.; Szymanowski, L.

    2017-02-01

    The QCD collinear factorization framework allows one to describe exclusive backward production of a J /ψ meson in pion-nucleon collisions in terms of pion-to-nucleon transition distribution amplitudes. We calculate the scattering amplitude at the leading order in the strong coupling constant and estimate the cross section of this reaction in the backward kinematical region for a medium energy pion beam available at the J-Parc experimental facility.

  18. Generation of Collapsed Cross Sections for Hatch 1 Cycles 1-3

    SciTech Connect

    Ade, Brian J

    2012-11-01

    Under NRC JCN V6361, Oak Ridge National Laboratory (ORNL) was tasked to develop and run SCALE/TRITON models for generation of collapsed few-group cross sections and to convert the cross sections to PMAXS format using the GENPMAXS conversion utility for use in PARCS/PATHS simulations of Hatch Unit 1, cycles 1-3. This letter report documents the final models used to produce the Hatch collapsed cross sections.

  19. QCD Prediction of ATT for Small QT Dimuon Production in pp and pp-bar Collisions

    SciTech Connect

    Kawamura, Hiroyuki; Kodaira, Jiro; Tanaka, Kazuhiro

    2007-06-13

    We present QCD prediction of double-spin asymmetries (ATT) in transversely polarized Drell-Yan process at small transverse momentum QT of dimuon. Resummation of large logarithmic corrections, relevant in small QT region, is performed up to next-to-leading logarithmic (NLL) accuracy. ATT at RHIC, J-PARC and GSI are studied numerically in the corresponding kinematic regions. We show that the large ATT is obtained for small QT and moderate energies.

  20. A Session with TINKER: Interleaving Program Testing With Program Design.

    DTIC Science & Technology

    1980-09-01

    Smith’s Pygmalion , which pioneered the idea of menu-oriented programming. Our techniques of displaying examples and source code for programs...slimilar in spirit to Pygmalion , and both these systems made interesting use of graphical rather than textual representations of programs, which we have not...demionstrating his Pygmalion 1 * ,ti to uts and discussing it with us on a visit to Xerox PARC, and G. J. Curry’ for leiiding uts a \\ideoiaped demonstration of

  1. Chemical Defects and Electronics States in Organic Semiconductors

    DTIC Science & Technology

    2008-05-31

    binding is indeed larger in PATT than in PBTTT (by 40%). Colleagues at PARC and Imperial College ( lain McCulloch) have characterized the properties of...P A TT and a paper including theoretical and experimental results (mobility, structure, and thermal properties) was submitted for publication. (J. E...acceptors. This model explains for the first time why exposure of pentacene to oxygen in the presence of an electric field leads top-type doping of the

  2. Streptococcus pyogenes Pharyngeal Isolates with Reduced Susceptibility to Ciprofloxacin in Spain: Mechanisms of Resistance and Clonal Diversity

    PubMed Central

    Albertí, Sebastián; Cortés, Guadalupe; García-Rey, Cesar; Rubio, Carmen; Baquero, Fernando; García-Rodríguez, José Ángel; Bouza, Emilio; Aguilar, Lorenzo

    2005-01-01

    A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC, mainly replacement of serine-79 by alanine. PMID:15616324

  3. Dollar Summary of Prime Contract Awards by State, Place, and Contractor, FY84, Part 4, (Allenville, Missouri-Wyoming, Pennsylvania).

    DTIC Science & Technology

    1984-01-01

    CLOSED CIRCUIT TV CORP 26 26INGERSOLL-RAND COMPANY INC 67 67INSTITUTE FOR ADVANCED STUDY 75 75 INTERNATIONAL BUSINESS MCHS 28 28M L ENERGIA INC 30...I 28 PRINCETON E 0 & 0 PARC 28 IBM CORP 25 25 M L ENERGIA INC 107 107 SAN LUIS CAMERA 41 41...SANDERS ASSOCIATES INC 848 848 SATELLITE SERVICES INC 237 237 SCHICKEL H GEN CONTR INC 132 132 SHERLOT HOME RENOVATION CORP 317 317 TRACY TROMBLEY CONT

  4. Updating Boer-Mulders functions from unpolarized pd and pp Drell-Yan data

    SciTech Connect

    Lu Zhun; Schmidt, Ivan

    2010-02-01

    We extract the Boer-Mulders functions for the proton by combining the unpolarized pd and pp Drell-Yan data measured by the E866/NuSea Collaboration by the assumption that the cos2{phi} asymmetry is from the Boer-Mulders functions. Using the extracted Boer-Mulders functions, we present the predictions for the cos2{phi} asymmetries in future pp experiments at J-PARC and pp experiments at PANDA and PAX.

  5. Historical Review of Atomic Frequency Standards Used in Space Systems - 10 Year Update

    DTIC Science & Technology

    2007-01-01

    CASSINI - HUYGENS MISSION The Cassini - Huygens mission to Saturn and its moon Titan began with the launch on 15 October 1997 and completed with the...The transmitter ultrastable oscillator (TUSO) was on the Huygens probe and the receiver ultrastable oscillator (RUSO) was on the Cassini orbiter...the newer systems (Galileo, GPS IIR and IIF, GLONASS-M, Cassini - Huygens , AEHF, and QZSS) and potential space systems (PARCS and PHARAO) using atomic

  6. Association of norB overexpression and fluoroquinolone resistance in clinical isolates of Staphylococcus aureus from Korea

    PubMed Central

    Kwak, Yee Gyung; Truong-Bolduc, Que Chi; Bin Kim, Hong; Song, Kyoung-Ho; Kim, Eu Suk; Hooper, David C.

    2013-01-01

    Objectives Although the prevalence of fluoroquinolone resistance among methicillin-resistant Staphylococcus aureus (MRSA) is known to be higher than in methicillin-susceptible S. aureus (MSSA), the reasons have never been identified. Methods We randomly selected 115 isolates of S. aureus collected from 10 different hospitals in Korea between June 2009 and May 2011. To investigate the difference in fluoroquinolone resistance mechanisms between MRSA and MSSA, we evaluated gyrA and parC mutations and the relative expression of the multidrug efflux pump genes norA, norB and norC. Results All 62 ciprofloxacin-resistant S. aureus had either gyrA or parC mutations. The S84L mutation of gyrA (59/62, 95.2%) and the S80F mutation of parC (61/62, 98.4%) were the most common. Fifty-eight (93.6%) strains had both the S84L mutation of gyrA and the S80F mutation of parC. Among the 115 isolates, norB overexpression was the most common, occurring in 49 (42.6%) strains. There were only two (1.7%) strains with norA overexpression and none with norC overexpression. Strains overexpressing norB were more common among ciprofloxacin-resistant S. aureus (33/62, 53.2%) than ciprofloxacin-susceptible S. aureus (16/53, 30.2%) (P = 0.013). When we analysed 62 ciprofloxacin-resistant S. aureus strains, those overexpressing norB were more common in ciprofloxacin-resistant MRSA (28/46, 60.9%) than in ciprofloxacin-resistant MSSA (5/16, 31.3%) (P = 0.041). Conclusions Increased expression of norB can be a factor that contributes to ciprofloxacin resistance in MRSA strains. PMID:23928023

  7. [Mutation window for the "pneumococcus-fluoroquinolone" couple. Contribution of experimental models].

    PubMed

    Chavanet, P; Croisier, D

    2006-01-01

    Low-level resistance to fluoroquinolones (in vitro susceptible but with topoisomerase mutation, parC) is currently rare among pneumococci in France. However, this resistance is more frequently observed in previously exposed patients and therapeutic failure has been reported. These issues were investigated by using a humanized model of experimental pneumonia induced by pneumococci exhibiting this low-level resistance profile. The results are as follows: 1) when the pneumonia is due to a wild type pneumococcus, humanized ciprofloxacin treatment is not effective because of resistant mutants with parC mutation; moreover, levoflaxin treatment is less bactericidal than gatiflo- or moxifloxacin (-4 vs -6 log CFU/g); 2) when an efflux strain is used, levo-treatment is not efficient but there are no mutants, a gatiflo-treatment is combined when mutants appear and moxiflo-treatment is effective; 3) when the pneumonia is induced with susceptible parC strains, treatment with either levo, or gati, or moxifloxacin is completely ineffective because resistant mutants appear (acquisition of another gyrA mutation). Measure of the mutation prevention concentration (MPC) allows anticipating these results since the mutation window can be determined. These results stress the necessity to identify patients with such pneumococcal strains in order to avoid therapeutic failure and the emergence of fluoroquinolone resistant mutants.

  8. The impact of a novel educational curriculum for first-time DUI offenders on intermediate outcomes relevant to DUI recidivism.

    PubMed

    Rider, Raamses; Kelley-Baker, Tara; Voas, Robert B; Murphy, Bernard; McKnight, A James; Levings, Charles

    2006-05-01

    The Preventing Alcohol-Related Convictions (PARC) program is a novel educational curriculum for first-time DUI offenders, with the ultimate goal of reducing DUI recidivism. It differs from traditional DUI education and prevention programs in that it does not suggest to DUI offenders that they must abstain from alcohol entirely or control their drinking to prevent a future DUI; rather, it teaches students to prevent a future DUI by not driving their cars to drinking events. Thus, the emphasis of the curriculum is on controlling driving rather than controlling drinking to avoid future DUI convictions. The implementation of the program is ongoing throughout the state of Florida. The current randomized study focused on intermediate outcomes relevant for DUI recidivism; specifically, individuals' readiness for change regarding drinking and driving, and their endorsement of a PARC planning and action approach (controlling driving) versus a traditional approach (controlling drinking). The current research demonstrated that the PARC program is effective in moving participants toward more readiness for change and toward a strategy of planning ahead to avoid driving to any venue in which drinking may occur. Future research will assess the ultimate effect on DUI recidivism.

  9. A High Power Test Method for Pattern Magnet Power Supplies with Capacitor Banks

    NASA Astrophysics Data System (ADS)

    Kurimoto, Yoshinori; Morita, Yuichi; Sagawa, Ryu; Shimogawa, Tetsushi; Miura, Kazuki

    In the J-PARC Main Ring (MR), we plan to increase the beam intensity from 230 to 750 kW. To achieve this, the synchrotron repetition period must be shortened from 2.48 s to approximately 1 s using new power supplies for the main magnets. We are currently researching and developing new power supplies with large capacitor banks. Such banks are needed to reduce the power variation at the main grid in the J-PARC site for future operations with shorter repetition periods. However, it is very difficult to test the new power supplies at their rated power before installation. This is because the power handled by the power supplies used for the J-PARC MR main magnets is too high to be tested in factories or laboratories. To overcome this problem, we suggest a test method involving the use of two capacitor banks. In this method, two power supplies and a small inductive load are connected between two capacitor banks. By controlling the energy flow between the two capacitor banks in this setup, the received power and inductive load can be kept very small. This article describes the details of the control method and the results of the test experiment using a mini-model power supply.

  10. A computational fluid dynamics simulation of the hypersonic flight of the Pegasus(TM) vehicle using an artificial viscosity model and a nonlinear filtering method. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Mendoza, John Cadiz

    1995-01-01

    The computational fluid dynamics code, PARC3D, is tested to see if its use of non-physical artificial dissipation affects the accuracy of its results. This is accomplished by simulating a shock-laminar boundary layer interaction and several hypersonic flight conditions of the Pegasus(TM) launch vehicle using full artificial dissipation, low artificial dissipation, and the Engquist filter. Before the filter is applied to the PARC3D code, it is validated in one-dimensional and two-dimensional form in a MacCormack scheme against the Riemann and convergent duct problem. For this explicit scheme, the filter shows great improvements in accuracy and computational time as opposed to the nonfiltered solutions. However, for the implicit PARC3D code it is found that the best estimate of the Pegasus experimental heat fluxes and surface pressures is the simulation utilizing low artificial dissipation and no filter. The filter does improve accuracy over the artificially dissipative case but at a computational expense greater than that achieved by the low artificial dissipation case which has no computational time penalty and shows better results. For the shock-boundary layer simulation, the filter does well in terms of accuracy for a strong impingement shock but not as well for weaker shock strengths. Furthermore, for the latter problem the filter reduces the required computational time to convergence by 18.7 percent.

  11. Trace Assessment for BWR ATWS Analysis

    SciTech Connect

    Cheng, L.Y.; Diamond, D.; Arantxa Cuadra, Gilad Raitses, Arnold Aronson

    2010-04-22

    A TRACE/PARCS input model has been developed in order to be able to analyze anticipated transients without scram (ATWS) in a boiling water reactor. The model is based on one developed previously for the Browns Ferry reactor for doing loss-of-coolant accident analysis. This model was updated by adding the control systems needed for ATWS and a core model using PARCS. The control systems were based on models previously developed for the TRAC-B code. The PARCS model is based on information (e.g., exposure and moderator density (void) history distributions) obtained from General Electric Hitachi and cross sections for GE14 fuel obtained from an independent source. The model is able to calculate an ATWS, initiated by the closure of main steam isolation valves, with recirculation pump trip, water level control, injection of borated water from the standby liquid control system and actuation of the automatic depres-surization system. The model is not considered complete and recommendations are made on how it should be improved.

  12. Installed F/A-18 inlet flow calculations at 60 deg angle-of-attack and 10 deg side slip

    NASA Technical Reports Server (NTRS)

    Podleski, S. D.

    1993-01-01

    This paper presents the results of PARC3D numerical calculations on a 19.78 percent scale forebody/inlet model of the F/A-18 at a Mach number of 0.20, an angle-of-attack of 60 deg, and a side-slip angle of 10 deg. The main purpose of these calculations is to support an upcoming wind-tunnel test program in the prediction of engine inlet compressor face total pressure recovery and flow distortion. The GRIDGEN system was used to generate a grid which includes the inlet and lip, and other aircraft components which are considered to be important to inlet performance, such as the ramp/splitter plate, the diverter and slot, and the deflected leading edge flap. PARC3D shows complex flow patterns on the fuselage surfaces below the leading edge extensions, on the ramp/splitter plate, inlet lip, and inside the inlet. PARC3D tends to underpredict total pressure recovery and overpredict the flow distortion at the inlet compressor face.

  13. Molecular characterization of quinolone resistance-determining regions and their correlation with serotypes and genotypes among Streptococcus pneumoniae isolates in Japan.

    PubMed

    Osawa, M; Ito, Y; Ishida, T; Imai, S; Ichiyama, S; Mishima, M

    2010-02-01

    We established the distribution of amino acid alterations in quinolone resistance-determining regions (QRDRs) of Streptococcus pneumoniae isolates in Japan and described the correlation of these alterations with serotypes determined by multilocus sequencing typing. Among 141 S. pneumoniae isolates, five levofloxacin-resistant isolates harbored mutations in both gyrA and parC and/or parE and were clonally unrelated. Among 136 levofloxacin-susceptible isolates, one isolate (MIC = 2 mg/l) had a first-step parC mutation at Asp78. Twenty isolates had Lys137Asp in parC and Ile460Val in parE and contained nine serotypes and eight clonal complexes (CCs), including all eight Colombia(23F)-26 (CC138) isolates. Eighty-one isolates had Ile460Val in parE alone and contained 14 serotypes and 16 CCs, including 36 of 37 Netherlands(3)-31 (CC180) isolates and all 22 Taiwan(19F)-14 (CC271) isolates. In contrast, seven of ten Taiwan(23F)-15 (CC242) isolates were wild-type. Although each QRDR genotype contained various serotypes and CCs, prevalent clones were mostly associated with a single QRDR genotype.

  14. Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain.

    PubMed

    de la Campa, Adela G; Ardanuy, Carmen; Balsalobre, Luz; Pérez-Trallero, Emilio; Marimón, Jose M; Fenoll, Asunción; Liñares, Josefina

    2009-06-01

    Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC >or=16 microg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006.

  15. Fluoroquinolone resistance in Streptococcus pneumoniae from a university hospital, Thailand.

    PubMed

    Srifuengfung, Somporn; Tribuddharat, Chanwit; Chokephaibulkit, Kulkanya; Comerungsee, Sopita

    2010-11-01

    The most frequent markers of fluoroquinolone resistance in S. pneumoniae are chromosomal mutations in the quinolone-resistance-determining regions of DNA gyrase and topoisomerase IV encoding for the gyrA, gyrB and parC, parE genes. In 2008, 6.5% of the Streptococcus pneumoniae isolates in a Bangkok university hospital were resistant to ofloxacin. Using PCR and DNA sequencing, we identified mutations in both the gyrA and parC genes of four ofloxacin- and ciprofloxacin-resistant S. pneumoniae isolates (minimum inhibitory concentrations > 32 microg/ml). Mutations were found in the gyrA gene at positions Ser81Phe, Glu85Gly, Glu85Lys and in the parC gene at position Ser79Tyr. Three isolates had mutations in both genes. Two of the isolates were serotype 6B and two were serotypes not contained in currently licensed pneumococcal vaccines. This is the first report of the mechanisms of fluoroquinolone resistance in S. pneumoniae in Thailand.

  16. Use of Navier-Stokes methods for the calculation of high-speed nozzle flow fields

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.; Yoder, Dennis A.

    1994-01-01

    Flows through three reference nozzles have been calculated to determine the capabilities and limitations of the widely used Navier-Stokes solver, PARC. The nozzles examined have similar dominant flow characteristics as those considered for supersonic transport programs. Flows from an inverted velocity profile (IVP) nozzle, an under expanded nozzle, and an ejector nozzle were examined. PARC calculations were obtained with its standard algebraic turbulence model, Thomas, and the two-equation turbulence model, Chien k-epsilon. The Thomas model was run with the default coefficient of mixing set at both 0.09 and a larger value of 0.13 to improve the mixing prediction. Calculations using the default value substantially underpredicted the mixing for all three flows. The calculations obtained with the higher mixing coefficient better predicted mixing in the IVP and underexpanded nozzle flows but adversely affected PARC's convergence characteristics for the IVP nozzle case. The ejector nozzle case did not converge with the Thomas model and the higher mixing coefficient. The Chien k-epsilon results were in better agreement with the experimental data overall than were those of the Thomas run with the default mixing coefficient, but the default boundary conditions for k and epsilon underestimated the levels of mixing near the nozzle exits.

  17. Antimicrobial resistance and genetic characterization of fluoroquinolone-resistant Mannheimia haemolytica isolates from cattle with bovine pneumonia.

    PubMed

    Katsuda, Ken; Kohmoto, Mariko; Mikami, Osamu; Uchida, Ikuo

    2009-10-20

    Antimicrobial susceptibility and molecular characterization of quinolone-resistant Mannheimia haemolytica was conducted. The antimicrobial susceptibility of 229 M. haemolytica isolates which were obtained from cattle with bovine respiratory disease during the period 1984-2006, was determined using 14 antimicrobial agents. Of the 229 isolates, 114 (49.8%) were resistant to at least one agent and resistance rates ranged from 4.8% to 31.4%. Resistance rates for dihydrostreptomycin, oxytetracycline, doxycycline, ampicillin, amoxicillin, thiamphenicol, kanamycin chloramphenicol, nalidixic acid, enrofloxacin, and danofloxacin were 31.4%, 20.5%, 18.3%, 19.2%, 16.6%, 10.9%, 11.4%, 10.5%, 17.0%, 4.8% and 4.8%, respectively. The nucleotide sequences of the quinolone resistance-determining regions of the gyrA and parC genes of nalidixic acid-resistant M. haemolytica were determined. All nalidixic acid-resistant strains possessed at least one amino acid substitution in each of the GyrA and ParC fragments investigated. These results suggest that M. haemolytica require at least one amino acid substitution in both GyrA and ParC in order to attain significant levels of resistance to quinolones. All fluoroquinolone-resistant isolates belonged to serotype 6, and their genotype by PFGE analysis was identical. This result indicates that fluoroquinolone-resistant M. haemolytica strains have clonally expanded.

  18. Stabilization of rinderpest vaccine by modification of the lyophilization process.

    PubMed

    House, J A; Mariner, J C

    1996-01-01

    Rinderpest (RP), a lethal disease of cattle, was almost eradicated from the African continent under Joint Project 15 (JP15), using an excellent modified live virus vaccine. Due to marked instability of the vaccine, a cold chain was required to ensure that the vaccine was potent at the time of application. Rinderpest re-emerged in the early 1980s. The Pan African Rinderpest Campaign (PARC) was developed to combat the new epidemic. For PARC to be efficacious and affordable, there was a clear need to have a vaccine that was thermostable. The need for a stable vaccine was underscored in politically unstable areas such as the Sudan, where the veterinary infrastructure has diminished and vaccination has been left in the hands of personnel who must act expeditiously. This paper reviews studies on various stabilizers and a modified lyophilization cycle that resulted in a highly thermostable RP vaccine. The useful shelf life of the vaccine, under African field conditions, was increased from less than one week to at least 100 days. For practical reasons, PARC recommends that the vaccine be used within 30 days of leaving refrigeration (the cold chain).

  19. Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to Streptococcus pneumoniae

    PubMed Central

    Balsalobre, Luz; Ferrándiz, María José; Liñares, Josefina; Tubau, Fe; de la Campa, Adela G.

    2003-01-01

    A total of 46 ciprofloxacin-resistant (Cipr) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cipr isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae. PMID:12821449

  20. Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain

    PubMed Central

    Ardanuy, Carmen; Balsalobre, Luz; Pérez-Trallero, Emilio; Marimón, Jose M.; Fenoll, Asunción; Liñares, Josefina

    2009-01-01

    Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4–8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006. PMID:19523289

  1. In vitro selection of resistance to pradofloxacin and ciprofloxacin in canine uropathogenic Escherichia coli isolates.

    PubMed

    Liu, Xiaoqiang; Lazzaroni, Caterina; Aly, Sherine A; Thungrat, Kamoltip; Boothe, Dawn M

    2014-12-05

    This study explored and compared the mechanisms and selective concentration of resistance between a 3rd (pradofloxacin) and 2nd (ciprofloxacin) generation fluoroquinolone. Pradofloxacin- and ciprofloxacin-resistant mutants were selected by stepwise exposure of Escherichia coli (E. coli) to escalating concentrations of pradofloxacin and ciprofloxacin. The sequence of the quinolone resistance determining region (QRDR) and the transcriptional regulator soxS were analyzed, and efflux pump AcrAB-TolC activity was measured by quantitative real-time reverse transcription-PCR (qRT-PCR). First-step mutants reduced the fluoroquinolone sensitivity and one mutant bore a single substitution in gyrA. Four of six second-step mutants expressed ciprofloxacin resistance, and displayed additional mutations in gyrA and/or parC, while these mutants retained susceptibility to pradofloxacin. All the third-step mutants were fluoroquinolone resistant, and each expressed multidrug resistance (MDR) phenotypes. Further, they displayed resistance to all antibacterials tested except cefotaxime, ceftazidime and meropenem. The number of mutations in QRDR of gyrA and parC correlated with fluoroquinolone MICs. Mutations in parC were not common in pradofloxacin-associated mutants. Moreover, one second- and one third-step ciprofloxacin-associated mutants bore both mutations at position 12 (Ala12Ser) and 78 (Met78Leu) in the soxS gene, yet no mutations in the soxS gene were detected in the pradofloxacin-selected mutants. Altogether, these results demonstrated that resistance emerged relatively more rapidly in 2nd compared to 3rd generation fluoroquinolones. Point mutations in gyrA were a key mechanism of resistance to pradofloxacin, and overexpression of efflux pump gene acrB played a potential role in the emergence of MDR phenotypes identified in this study.

  2. Prevalence of gyrA Mutations in Nalidixic Acid-Resistant Strains of Salmonella Enteritidis Isolated from Humans, Food, Chickens, and the Farm Environment in Brazil.

    PubMed

    Campioni, Fábio; Souza, Roberto Antonio; Martins, Vinicius Vicente; Stehling, Eliana Guedes; Bergamini, Alzira Maria Morato; Falcão, Juliana Pfrimer

    2016-08-25

    Salmonella Enteritidis strains that are resistant to nalidixic acid and exhibit reduced susceptibility to fluoroquinolones have been increasing worldwide. In Brazil, few studies have been conducted to elucidate the quinolone resistance mechanisms of S. Enteritidis strains. This study analyzed the profile of gyrA, gyrB, parC, and parE mutations and plasmid-mediated quinolone resistance (PMQR) mechanisms in S. Enteritidis Nal(R) strains isolated in Brazil. Moreover, the minimum inhibitory concentrations (MICs) of ciprofloxacin were evaluated in 84 Nal(R) strains and compared with 20 Nal(S) strains. The mutation profiles of the gyrA gene were accessed by high-resolution melting analysis and gyrB, parC, and parE by quinolone resistance-determining region sequencing. The MICs of ciprofloxacin were accessed with Etest(®). The strains were divided into five gyrA melting profiles. The Nal(R) strains exhibited the following amino acid substitutions: Ser97→Pro, Ser83→Phe, Asp87→Asn, or Asp87→Tyr. The average MICs of ciprofloxacin was 0.006 μg/ml in the Nal(S) and 0.09 μg/ml in the Nal(R) strains. No points of mutation were observed in the genes gyrB, parC, and parE. The qnrB gene was found in two strains. In conclusion, the reduced susceptibility to ciprofloxacin observed in Nal(R) strains may cause treatment failures once this drug is commonly used to treat Salmonella infections. Moreover, this reduced susceptibility in these Brazilian strains was provided by target alteration of gene gyrA and not by mobile elements, such as resistance plasmids.

  3. Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype

    PubMed Central

    Agnello, Melissa; Finkel, Steven E.; Wong-Beringer, Annie

    2016-01-01

    Fluoroquinolone (FQ) resistance is highly prevalent among clinical strains of Pseudomonas aeruginosa, limiting treatment options. We have reported previously that highly virulent strains containing the exoU gene of the type III secretion system are more likely to be FQ-resistant than strains containing the exoS gene, as well as more likely to acquire resistance-conferring mutations in gyrA/B and parC/E. We hypothesize that FQ-resistance imposes a lower fitness cost on exoU compared to exoS strains, thus allowing for better adaptation to the FQ-rich clinical environment. We created isogenic mutants containing a common FQ-resistance conferring point mutation in parC from three exoU to three exoS clinical isolates and tested fitness in vitro using head-to-head competition assays. The mutation differentially affected fitness in the exoU and exoS strains tested. While the addition of the parC mutation dramatically increased fitness in one of the exoU strains leaving the other two unaffected, all three exoS strains displayed a general decrease in fitness. In addition, we found that exoU strains may be able to compensate for the fitness costs associated with the mutation through better regulation of supercoiling compared to the exoS strains. These results may provide a biological explanation for the observed predominance of the virulent exoU genotype in FQ-resistant clinical subpopulations and represent the first investigation into potential differences in fitness costs of FQ-resistance that are linked to the virulence genotype of P. aeruginosa. Understanding the fitness costs of antibiotic resistance and possibilities of compensation for these costs is essential for the rational development of strategies to combat the problem of antibiotic resistance. PMID:27757111

  4. Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters

    PubMed Central

    Soscia, David A.; Sequeira, Sharon J.; Schramm, Robert A.; Jayarathanam, Kavitha; Cantara, Shraddha I.; Larsen, Melinda; Castracane, James

    2013-01-01

    There is a need for an artificial salivary gland as a long-term remedy for patients suffering from salivary hypofunction, a leading cause of chronic xerostomia (dry mouth). Current salivary gland tissue engineering approaches are limited in that they either lack sufficient physical cues and surface area needed to facilitate epithelial cell differentiation, or they fail to provide a mechanism for assembling an interconnected branched network of cells. We have developed highly-ordered arrays of curved hemispherical “craters” in polydimethylsiloxane (PDMS) using wafer-level integrated circuit (IC) fabrication processes, and lined them with electrospun poly-lactic-co-glycolic acid (PLGA) nanofibers, designed to mimic the three-dimensional (3-D) in vivo architecture of the basement membrane surrounding spherical acini of salivary gland epithelial cells. These micropatterned scaffolds provide a method for engineering increased surface area and were additionally investigated for their ability to promote cell polarization. Two immortalized salivary gland cell lines (SIMS, ductal and Par-C10, acinar) were cultured on fibrous crater arrays of various radii and compared with those grown on flat PLGA nanofiber substrates, and in 3-D Matrigel. It was found that by increasing crater curvature, the average height of the cell monolayer of SIMS cells and to a lesser extent, Par-C10 cells, increased to a maximum similar to that seen in cells grown in 3-D Matrigel. Increasing curvature resulted in higher expression levels of tight junction protein occludin in both cell lines, but did not induce a change in expression of adherens junction protein Ecadherin. Additionally, increasing curvature promoted polarity of both cell lines, as a greater apical localization of occludin was seen in cells on substrates of higher curvature. Lastly, substrate curvature increased expression of the water channel protein aquaporin-5 (Aqp-5) in Par-C10 cells, suggesting that curved nanofiber

  5. Genomic Characterization of Ciprofloxacin Resistance in a Laboratory-Derived Mutant and a Clinical Isolate of Streptococcus pneumoniae

    PubMed Central

    Lupien, Andréanne; Billal, Dewan S.; Fani, Fereshteh; Soualhine, Hafid; Zhanel, George G.; Leprohon, Philippe

    2013-01-01

    The broad-spectrum fluoroquinolone ciprofloxacin is a bactericidal antibiotic targeting DNA topoisomerase IV and DNA gyrase encoded by the parC and gyrA genes. Resistance to ciprofloxacin in Streptococcus pneumoniae mainly occurs through the acquisition of mutations in the quinolone resistance-determining region (QRDR) of the ParC and GyrA targets. A role in low-level ciprofloxacin resistance has also been attributed to efflux systems. To look into ciprofloxacin resistance at a genome-wide scale and to discover additional mutations implicated in resistance, we performed whole-genome sequencing of an S. pneumoniae isolate selected for resistance to ciprofloxacin in vitro (128 μg/ml) and of a clinical isolate displaying low-level ciprofloxacin resistance (2 μg/ml). Gene disruption and DNA transformation experiments with PCR fragments harboring the mutations identified in the in vitro S. pneumoniae mutant revealed that resistance is mainly due to QRDR mutations in parC and gyrA and to the overexpression of the ABC transporters PatA and PatB. In contrast, no QRDR mutations were identified in the genome of the S. pneumoniae clinical isolate with low-level resistance to ciprofloxacin. Assays performed in the presence of the efflux pump inhibitor reserpine suggested that resistance is likely mediated by efflux. Interestingly, the genome sequence of this clinical isolate also revealed mutations in the coding region of patA and patB that we implicated in resistance. Finally, a mutation in the NAD(P)H-dependent glycerol-3-phosphate dehydrogenase identified in the S. pneumoniae clinical strain was shown to protect against ciprofloxacin-mediated reactive oxygen species. PMID:23877698

  6. Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.

    PubMed

    Crane, Daniel P; Gromov, Kirill; Li, Dan; Søballe, Kjeld; Wahnes, Christian; Büchner, Hubert; Hilton, Matthew J; O'Keefe, Regis J; Murray, Clinton K; Schwarz, Edward M

    2009-08-01

    Osteomyelitis (OM) from multidrug-resistant (MDR) Acinetobacter has emerged in >30% of combat-related injuries in Iraq and Afghanistan. While most of these strains are sensitive to colistin, the drug is not available in bone void fillers for local high-dose delivery. To address this, we developed a mouse model with MDR strains isolated from wounded military personnel. In contrast to S. aureus OM, which is osteolytic and characterized by biofilm in necrotic bone, A. baumannii OM results in blastic lesions that do not contain apparent biofilm. We also found that mice mount a specific IgG response against three proteins (40, 47, and 56 kDa) regardless of the strain used, suggesting that these may be immuno-dominant antigens. PCR for the A. baumannii-specific parC gene confirmed a 100% infection rate with 75% of the MDR strains, and in vitro testing confirmed that all strains were sensitive to colistin. We also developed a real-time quantitative PCR (RTQ-PCR) assay that could detect as few as 10 copies of parC in a sample. To demonstrate the efficacy of colistin prophylaxis in this model, mice were treated with either parenteral colistin (0.2 mg colistinmethate i.m. for 7 days), local colistin (PMMA bead impregnated with 1.0 mg colistin sulfate), or an unloaded PMMA bead control. While the parenteral colistin failed to demonstrate any significant effects versus the placebo, the colistin PMMA bead significantly reduced the infection rate such that only 29.2% of the mice had detectable levels of parC at 19 days (p < 0.05 vs. i.m. colistin and placebo).

  7. Isolation and characterization of multidrug-resistant Klebsiella spp. isolated from shrimp imported from Thailand.

    PubMed

    Nawaz, Mohamed; Khan, S A; Tran, Q; Sung, K; Khan, A A; Adamu, I; Steele, R S

    2012-04-16

    A study was undertaken to isolate and characterize tetracycline and nalidixic acid-resistant Klebsiella spp. in farm-raised, imported shrimp sold in the United States. Sixty-seven multiple antibiotic-resistant Klebsiella spp. strains were isolated from imported shrimp samples. Using morphological and biochemical methods, fifty-three strains were tentatively identified as Klebsiella pneumoniae and fourteen as K. oxytoca. Although all isolates were resistant to tetracycline, only 8 were resistant to nalidixic acid. These 8 isolates were further screened by PCR for quinolone resistance genes (qnrA, B, S, gyrA, B and parC). PCR protocols failed to amplify any qnr genes. The purified PCR amplicons of gyrA, gyrB and parC were sequenced and analyzed for point mutations that confer resistance to fluoroquinolone antibiotics. Analysis of the sequences of the gyrA amplicons from nalidixic acid-resistant Klebsiella spp. indicated two point mutations in gyrA at positions 83 (Ser→Phe) and 87 (Asp→Ala). Sequence analysis of the parC amplicons indicated an amino acid change at position 80 (Ser→Ile). No mutations were detected in gyrB. Template DNA from all isolates was screened for tetracycline resistance genes (tetA-E). Oligonucleotide primers specifically targeting a 305-bp region of tetB and a 477-bp region of tetD successfully amplified sequences from 91.0 and 44.0% of the isolates, respectively. None of the isolates contained tetA, tetC or tetE genes. Plasmids (2.0-16.0kb) were found in 23 of the 67 isolates. XbaI-PFGE identified 32 distinct macro restriction patterns (mrps) among the 61 multiple drug-resistant Klebsiella spp. that were typable. Our results indicate that imported shrimp is a reservoir for multidrug resistant Klebsiella spp. and potential health risks posed by such strains should not be underestimated.

  8. Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype.

    PubMed

    Agnello, Melissa; Finkel, Steven E; Wong-Beringer, Annie

    2016-01-01

    Fluoroquinolone (FQ) resistance is highly prevalent among clinical strains of Pseudomonas aeruginosa, limiting treatment options. We have reported previously that highly virulent strains containing the exoU gene of the type III secretion system are more likely to be FQ-resistant than strains containing the exoS gene, as well as more likely to acquire resistance-conferring mutations in gyrA/B and parC/E. We hypothesize that FQ-resistance imposes a lower fitness cost on exoU compared to exoS strains, thus allowing for better adaptation to the FQ-rich clinical environment. We created isogenic mutants containing a common FQ-resistance conferring point mutation in parC from three exoU to three exoS clinical isolates and tested fitness in vitro using head-to-head competition assays. The mutation differentially affected fitness in the exoU and exoS strains tested. While the addition of the parC mutation dramatically increased fitness in one of the exoU strains leaving the other two unaffected, all three exoS strains displayed a general decrease in fitness. In addition, we found that exoU strains may be able to compensate for the fitness costs associated with the mutation through better regulation of supercoiling compared to the exoS strains. These results may provide a biological explanation for the observed predominance of the virulent exoU genotype in FQ-resistant clinical subpopulations and represent the first investigation into potential differences in fitness costs of FQ-resistance that are linked to the virulence genotype of P. aeruginosa. Understanding the fitness costs of antibiotic resistance and possibilities of compensation for these costs is essential for the rational development of strategies to combat the problem of antibiotic resistance.

  9. Prevalence and characterisation of plasmid-mediated quinolone resistance and mutations in the gyrase and topoisomerase IV genes among Shigella isolates from Henan, China, between 2001 and 2008.

    PubMed

    Yang, Haiyan; Duan, Guangcai; Zhu, Jingyuan; Zhang, Weidong; Xi, Yuanlin; Fan, Qingtang

    2013-08-01

    A total of 293 Shigella isolates were isolated from patients with diarrhoea in four villages of Henan, China. This study investigated the prevalence of the plasmid-mediated quinolone resistance (PMQR) genes qnrA, qnrB, qnrS, qepA and aac(6')-Ib-cr and compared the polymorphic quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE. Of the isolates, 292 were found to be resistant to nalidixic acid and pipemidic acid, whereas 77 were resistant to ciprofloxacin (resistance rate of 26.3%). Resistance of the Shigella isolates to ciprofloxacin significantly increased from 2001 to 2008 (P<0.05). A mutation in gyrA was present in 277 (94.5%) of the isolates and a mutation in parC was present in 19 (6.5%) of the isolates. Moreover, 168 (57.3%) of the isolates contained only the gyrA (Ser83Leu) mutation. In addition, 107 isolates had two gyrA point mutations (Ser83Leu and either Asp87Gly, Asp87Asn or Asp113Tyr) and 13 isolates had two gyrA point mutations (Ser83Leu and Asp87Gly or Gly214Ala) and one parC mutation (Ser80Ile). In addition, qepA and aac(6')-Ib-cr were present in 6 (2.05%) and 19 (6.48%) of the isolates, respectively. All but one of the PMQR-positive isolates with a ciprofloxacin minimum inhibitory concentration in the range 4-32μg/mL had a mutation in the QRDR. It is known that PMQR-positive Shigella isolates are common in China. This study found that there was a significant increase in mutation rates of the QRDR and the resistant rates to ciprofloxacin. Other mechanisms may be present in the isolates that also contribute to their resistance to ciprofloxacin.

  10. Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones

    PubMed Central

    Yamada, M; Yoshida, J; Hatou, S; Yoshida, T; Minagawa, Y

    2008-01-01

    Background: Staphylococcus epidermidis is one of the prominent pathogens in ocular infection. The prevalence of mutations in the quinolone resistance determining region (QRDR) area in S epidermidis isolated from the ocular surface and its association with fluoroquinolone resistance has not been fully elucidated. Methods: Mutations in the QRDR of gyrA, gyrB, parC, and parE genes of 138 isolates of S epidermidis recovered from the human conjunctival flora were analysed. The minimal inhibitory concentrations (MICs) of four fluoroquinolones (levofloxacin, gatifloxacin, moxifloxacin and tosufloxacin) against these isolates were also determined using agar dilution methods. Results: The MIC90 values of levofloxacin, gatifloxacin, moxifloxacin and tosufloxacin were 3.13, 1.56, 0.78 and 3.13 μg/ml, respectively. The MIC values of all fluoroquinolones showed a bimodal distribution (susceptible strain and less susceptible strain). Mutations with amino acid substitution in the QRDR were present in 70 (50.7%) isolates. 19 different combinations of mutations were detected: 3 isolates (2.2%) had four mutations, 8 (5.8%) had three mutations, 43 (31.2%) had double mutations and 16 (11.6%) had single mutations. Isolates with mutations in the QRDR of both gyrA and parC (n = 53) were less susceptible to fluoroquinolones. Conclusions: The present findings show that approximately half the S epidermidis isolates from the normal human conjunctiva have mutation(s) in the QRDR. The presence of mutations in both gyrA and parC is strongly associated with reduced susceptibility to fluoroquinolones. PMID:18460536

  11. Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark.

    PubMed

    Cavaco, Lina Maria; Frimodt-Møller, Niels; Hasman, Henrik; Guardabassi, Luca; Nielsen, Lene; Aarestrup, Frank Møller

    2008-06-01

    Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations (MICs) of nalidixic acid (NAL) and ciprofloxacin (CIP) were investigated in 124 Escherichia coli isolated from humans (n=85) and swine (n=39) in Denmark. The collection included 59 high-level CIP-resistant isolates (MIC >or= 4) from human (n=51) and pig origin (n=8) and 65 low-level CIP-resistant isolates (MIC >or= 0.125) from human (n=34) and pig origin (n=31). Resistance by target modification was screened by PCR amplification and sequencing of the quinolone resistance determining regions (QRDRs) of gyrA, gyrB, parC, and parE. QRDR mutations occurred in all except two isolates (98%). All high-level CIP-resistant E. coli had one or two mutations in gyrA in combination with mutations in parC or parE. Mutations in parC and parE were only found in combination with gyrA mutations, and no mutations were observed in gyrB. Efflux pump mechanisms were detected in 10 human (11.8%) and 29 porcine (74.4%) isolates by an efflux pump inhibitor (EPI) agar dilution assay. The aac(6')-Ib-cr gene mediating resistance by enzymatic modification was found in 12 high-level CIP-resistant human isolates. The qnrA and qnrS genes conferring quinolone resistance by target protection were detected in two human low-level CIP-resistant isolates that did not display NAL resistance. As expected, target mutation in QRDRs was the most prevalent mechanism of quinolone resistance. This mechanism was complemented by efflux mechanisms in most porcine isolates. Transferable resistance by target protection or enzymatic modification was less common (10%) and restricted to human isolates.

  12. Nonoptimal DNA Topoisomerases Allow Maintenance of Supercoiling Levels and Improve Fitness of Streptococcus pneumoniae ▿

    PubMed Central

    Balsalobre, Luz; Ferrándiz, María José; de Alba, Gabriela; de la Campa, Adela G.

    2011-01-01

    Fluoroquinolones, which target gyrase and topoisomerase IV, are used for treating Streptococcus pneumoniae infections. Fluoroquinolone resistance in this bacterium can arise via point mutation or interspecific recombination with genetically related streptococci. Our previous study on the fitness cost of resistance mutations and recombinant topoisomerases identified GyrAE85K as a high-cost change. However, this cost was compensated for by the presence of a recombinant topoisomerase IV (parC and parE recombinant genes) in strain T14. In this study, we purified wild-type and mutant topoisomerases and compared their enzymatic activities. In strain T14, both gyrase carrying GyrAE85K and recombinant topoisomerase IV showed lower activities (from 2.0- to 3.7-fold) than the wild-type enzymes. These variations of in vitro activity corresponded to changes of in vivo supercoiling levels that were analyzed by two-dimensional electrophoresis of an internal plasmid. Strains carrying GyrAE85K and nonrecombinant topoisomerases had lower (11.1% to 14.3%) supercoiling density (σ) values than the wild type. Those carrying GyrAE85K and recombinant topoisomerases showed either partial or total supercoiling level restoration, with σ values being 7.9% (recombinant ParC) and 1.6% (recombinant ParC and recombinant ParE) lower than those for the wild type. These data suggested that changes acquired by interspecific recombination might be selected because they reduce the fitness cost associated with fluoroquinolone resistance mutations. An increase in the incidence of fluoroquinolone resistance, even in the absence of further antibiotic exposure, is envisaged. PMID:21173181

  13. Air Traffic Control in Face of Users’ Demand and Economy Constraints.

    DTIC Science & Technology

    1983-02-01

    available "tomorrow" but in reality rapid implementation is restricted by finance and resources. 3.4.2 Avionics/Ground Aids Standards The progressive...op~ration difficile parce qu’elle dolt Stre entreprise A un moment aDl Los instructions relatives A la pr~sentation du projot do budget no mont pan...du budget approuvG ye servir A financer 1 ’achat d’ equip me nts nouf. falwant 1 ’objot dlun aentrat qul pr~voit *ntre autre dons qulle Monnale los

  14. Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli

    PubMed Central

    Johnston, Brian; Kuskowski, Michael A.; Sokurenko, Evgeni V.; Tchesnokova, Veronika

    2015-01-01

    The recent expansion of the H30 subclone of Escherichia coli sequence type 131 (ST131) and its CTX-M-15-associated H30Rx subset remains unexplained. Although ST131 H30 typically exhibits fluoroquinolone resistance, so do multiple other E. coli lineages that have not expanded similarly. To determine whether H30 isolates have more intense fluoroquinolone resistance than other fluoroquinolone-resistant E. coli isolates and to identify possible mechanisms, we determined the MICs for four fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin, and norfloxacin) among 89 well-characterized, genetically diverse fluoroquinolone-resistant E. coli isolates (48 non-H30 and 41 H30 [23 H30Rx and 18 H30 non-Rx]). We compared the MICs with the H30 and H30Rx status, the presence/number of nonsynonymous mutations in gyrA, parC, and parE, the presence of aac(6′)-1b-cr (an aminoglycoside/fluoroquinolone agent-modifying enzyme), and the efflux pump activity (measured as organic solvent tolerance [OST]). Among 1,518 recent E. coli clinical isolates, ST131 H30 predominated clonally, both overall and among the fluoroquinolone-resistant isolates. Among the 89 study isolates, compared with non-H30 isolates, H30 isolates exhibited categorically higher MICs for all four fluoroquinolone agents, higher absolute ciprofloxacin and norfloxacin MICs, more nonsynonymous mutations in gyrA, parC, and parE (specifically gyrA D87N, parC E84V, and parE I529L), and a numerically higher prevalence of (H30Rx-associated) aac(6′)-1b-cr but lower OST scores. All putative resistance mechanisms were significantly associated with the MICs [for aac(6′)-1b-cr: ciprofloxacin and norfloxacin only]. parC D87N corresponded with ST131 H30 and parE I529L with ST131 generally. Thus, more intense fluoroquinolone resistance may provide ST131 H30, especially H30Rx [if aac(6′)-1b-cr positive], with subtle fitness advantages over other fluoroquinolone-resistant E. coli strains. This urges both parsimonious

  15. FIRST trial: Lemay park collection plan

    DTIC Science & Technology

    2007-12-01

    la défense Canada – Valcartier (RDDC Valcartier), étant intéressé à l’évaluation d’un capteur imageur hyperspectral aéroporté canadien, a...l’infrarouge thermique de Telops sera opéré dans un avion dans une configuration de capteur en peigne pour obtenir des images hyperspectrales du parc...expériences : une expé- rience de détection de panache de gaz , une de plastique simulant un panache de gaz , DRDC Valcartier TN 2007-435 i une de

  16. Verification of a neutronic code for transient analysis in reactors with Hex-z geometry

    SciTech Connect

    Gonzalez-Pintor, S.; Verdu, G.; Ginestar, D.

    2012-07-01

    Due to the geometry of the fuel bundles, to simulate reactors such as VVER reactors it is necessary to develop methods that can deal with hexagonal prisms as basic elements of the spatial discretization. The main features of a code based on a high order finite element method for the spatial discretization of the neutron diffusion equation and an implicit difference method for the time discretization of this equation are presented and the performance of the code is tested solving the first exercise of the AER transient benchmark. The obtained results are compared with the reference results of the benchmark and with the results provided by PARCS code. (authors)

  17. Quinolone Resistance Mechanisms among Extended-Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli Isolated from Rivers and Lakes in Switzerland

    PubMed Central

    Zurfluh, Katrin; Abgottspon, Helga; Hächler, Herbert; Nüesch-Inderbinen, Magdalena; Stephan, Roger

    2014-01-01

    Sixty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from rivers and lakes in Switzerland were screened for individual strains additionally exhibiting a reduced quinolone susceptibility phenotype. Totally, 42 such isolates were found and further characterized for their molecular (fluoro)quinolone resistance mechanisms. PCR and sequence analysis were performed to identify chromosomal mutations in the quinolone resistance-determining regions (QRDR) of gyrA, gyrB, parC and parE and to describe the occurrence of the following plasmid-mediated quinolone resistance genes: qepA, aac-6′-Ib-cr, qnrA, qnrB, qnrC, qnrD and qnrS. The contribution of efflux pumps to the resistance phenotype of selected strains was further determined by the broth microdilution method in the presence and absence of the efflux pump inhibitor phe-arg-β-naphthylamide (PAβN). Almost all strains, except two isolates, showed at least one mutation in the QRDR of gyrA. Ten strains showed only one mutation in gyrA, whereas thirty isolates exhibited up to four mutations in the QRDR of gyrA, parC and/or parE. No mutations were detected in gyrB. Most frequently the amino-acid substitution Ser83→Leu was detected in GyrA followed by Asp87→Asn in GyrA, Ser80→Ile in ParC, Glu84→Val in ParC and Ser458→Ala in ParE. Plasmid-mediated quinolone resistance mechanisms were found in twenty isolates bearing QnrS1 (4/20), AAC-6′-Ib-cr (15/20) and QepA (1/20) determinants, respectively. No qnrA, qnrB, qnrC and qnrD were found. In the presence of PAβN, the MICs of nalidixic acid were decreased 4- to 32-fold. (Fluoro) quinolone resistance is due to various mechanisms frequently associated with ESBL-production in E. coli from surface waters in Switzerland. PMID:24755830

  18. Three-dimensional compressible turbulent computations for a diffusing S-duct

    NASA Technical Reports Server (NTRS)

    Smith, C. F.; Bruns, J. E.; Harloff, G. J.; Debonis, J. R.

    1992-01-01

    The purpose of the present study was to evaluate the capability of the computational fluid dynamics computer program PARC3D to model flow in a typical diffusing subsonic S-duct, with strong secondary flows. This evaluation is needed to provide confidence in the analysis of aircraft inlets, which have similar geometries. The performance predictions include total pressure profiles, static pressures, velocity profiles, boundary layer data, and skin friction data. Flow in the S-duct is subsonic, and the boundary layers are assumed to be turbulent. The results for both H and O grid solutions, are compared with existing test data.

  19. Muon-to-Electron Conversion with COMET

    NASA Astrophysics Data System (ADS)

    Uchida, Y.

    2014-09-01

    The Coherent Muon-to-Electron Transition (COMET) experiment is presented, focusing on the particle detection systems. COMET is currently under construction as the first of two phases at the J-PARC proton accelerator laboratory in Tokai, Japan. COMET will search for muon-to-electron conversion with a single-event sensitivity of 2.6 × 10-17, with Phase-I achieving a sensitivity of 3.1 × 10-15 and due to enter commissioning in 2016. Phase-I will also allow us to study the novel pion and muon beamline and the rates of background processes.

  20. Numerical analysis and experiment to identify origin of buckling in rapid cycling synchrotron core

    NASA Astrophysics Data System (ADS)

    Morita, Y.; Kageyama, T.; Akoshima, M.; Torizuka, S.; Tsukamoto, M.; Yamashita, S.; Yoshikawa, N.

    2013-11-01

    The accelerating cavities used in the rapid cycling synchrotron (RCS) of the Japan Proton Accelerator Research Complex (J-PARC) are loaded with magnetic alloy (MA) cores. Over lengthly periods of RCS operation, significant reductions in the impedance of the cavities resulting from the buckling of the cores were observed. A series of thermal structural simulations and compressive strength tests showed that the buckling can be attributed to the low-viscosity epoxy resin impregnation of the MA core that causes the stiffening of the originally flexible MA-ribbon-wound core. Our results showed that thermal stress can be effectively reduced upon using a core that is not epoxy-impregnated.

  1. Interdigital H -mode drift-tube linac design with alternative phase focusing for muon linac

    NASA Astrophysics Data System (ADS)

    Otani, M.; Mibe, T.; Yoshida, M.; Hasegawa, K.; Kondo, Y.; Hayashizaki, N.; Iwashita, Y.; Iwata, Y.; Kitamura, R.; Saito, N.

    2016-04-01

    We have developed an interdigital H-mode (IH) drift-tube linac (DTL) design with an alternative phase focusing (APF) scheme for a muon linac, in order to measure the anomalous magnetic moment and electric dipole moment (EDM) of muons at the Japan Proton Accelerator Research Complex (J-PARC). The IH-DTL accelerates muons from β =v /c =0.08 to 0.28 at an operational frequency of 324 MHz. The output beam emittances are calculated as 0.315 π and 0.195 π mm mrad in the horizontal and vertical directions, respectively, which satisfies the experimental requirement.

  2. Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli.

    PubMed

    Johnson, James R; Johnston, Brian; Kuskowski, Michael A; Sokurenko, Evgeni V; Tchesnokova, Veronika

    2015-08-01

    The recent expansion of the H30 subclone of Escherichia coli sequence type 131 (ST131) and its CTX-M-15-associated H30Rx subset remains unexplained. Although ST131 H30 typically exhibits fluoroquinolone resistance, so do multiple other E. coli lineages that have not expanded similarly. To determine whether H30 isolates have more intense fluoroquinolone resistance than other fluoroquinolone-resistant E. coli isolates and to identify possible mechanisms, we determined the MICs for four fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin, and norfloxacin) among 89 well-characterized, genetically diverse fluoroquinolone-resistant E. coli isolates (48 non-H30 and 41 H30 [23 H30Rx and 18 H30 non-Rx]). We compared the MICs with the H30 and H30Rx status, the presence/number of nonsynonymous mutations in gyrA, parC, and parE, the presence of aac(6')-1b-cr (an aminoglycoside/fluoroquinolone agent-modifying enzyme), and the efflux pump activity (measured as organic solvent tolerance [OST]). Among 1,518 recent E. coli clinical isolates, ST131 H30 predominated clonally, both overall and among the fluoroquinolone-resistant isolates. Among the 89 study isolates, compared with non-H30 isolates, H30 isolates exhibited categorically higher MICs for all four fluoroquinolone agents, higher absolute ciprofloxacin and norfloxacin MICs, more nonsynonymous mutations in gyrA, parC, and parE (specifically gyrA D87N, parC E84V, and parE I529L), and a numerically higher prevalence of (H30Rx-associated) aac(6')-1b-cr but lower OST scores. All putative resistance mechanisms were significantly associated with the MICs [for aac(6')-1b-cr: ciprofloxacin and norfloxacin only]. parC D87N corresponded with ST131 H30 and parE I529L with ST131 generally. Thus, more intense fluoroquinolone resistance may provide ST131 H30, especially H30Rx [if aac(6')-1b-cr positive], with subtle fitness advantages over other fluoroquinolone-resistant E. coli strains. This urges both parsimonious fluoroquinolone

  3. Neutron lifetime measurement with pulsed beam at JPARC: Overview

    NASA Astrophysics Data System (ADS)

    Mishima, Kenji; Ino, Takashi; Taketani, Kaoru; Yamada, Takahito; Katayama, Ryo; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Yamashita, Satoru; Sakakibara, Risa; Sugino, Tomoaki; Kitaguchi, Masaaki; Hirota, Katsuya; Shimizu, Hirohiko M.; Tanaka, Genki; Sumi, Naoyuki; Otono, Hidetoshi; Yoshioka, Tamaki; Kitahara, Ryunosuke; Iwashita, Yoshihisa; Oide, Hideyuki; Shima, Tatsushi; Seki, Yoshichika; NOP Collaboration

    2014-09-01

    The neutron lifetime is an important parameter for a test of the Standard Model of elementary particles, as well for the production of light mass nuclei in big bang nucleosynthesis. There are two principally different approaches to measure the neutron lifetime: In-beam methods and storage of ultracold neutron. At present, there is a discrepancy of 8.4 sec (3.8 sigma) between the two methods. We are performing a new In-beam experiment with an intense pulsed neutron source at J-PARC, which has different systematic uncertainties from the previous experiments. We introduce the overview of the experiment and report present status.

  4. Development of time projection chamber for precise neutron lifetime measurement using pulsed cold neutron beams

    NASA Astrophysics Data System (ADS)

    Arimoto, Y.; Higashi, N.; Igarashi, Y.; Iwashita, Y.; Ino, T.; Katayama, R.; Kitaguchi, M.; Kitahara, R.; Matsumura, H.; Mishima, K.; Nagakura, N.; Oide, H.; Otono, H.; Sakakibara, R.; Shima, T.; Shimizu, H. M.; Sugino, T.; Sumi, N.; Sumino, H.; Taketani, K.; Tanaka, G.; Tanaka, M.; Tauchi, K.; Toyoda, A.; Tomita, T.; Yamada, T.; Yamashita, S.; Yokoyama, H.; Yoshioka, T.

    2015-11-01

    A new time projection chamber (TPC) was developed for neutron lifetime measurement using a pulsed cold neutron spallation source at the Japan Proton Accelerator Research Complex (J-PARC). Managing considerable background events from natural sources and the beam radioactivity is a challenging aspect of this measurement. To overcome this problem, the developed TPC has unprecedented features such as the use of polyether-ether-ketone plates in the support structure and internal surfaces covered with 6Li-enriched tiles to absorb outlier neutrons. In this paper, the design and performance of the new TPC are reported in detail.

  5. Sivers effect in Drell-Yan processes

    SciTech Connect

    Anselmino, M.; Boglione, M.; Melis, S.; Prokudin, A.; D'Alesio, U.; Murgia, F.

    2009-03-01

    The Sivers distributions recently extracted from semi-inclusive deep inelastic scattering data [M. Anselmino et al., Eur. Phys. J. A 39, 89 (2009)] are used to compute estimates for Sivers asymmetries in Drell-Yan processes which are being planned at several facilities (RHIC, COMPASS, J-PARC, PAX, PANDA, NICA (JINR) and SPASCHARM (IHEP)). Most of these asymmetries turn out to be large and could allow a clear test of the predicted sign change of the Sivers distributions when active in SIDIS and Drell-Yan processes. This is regarded as a fundamental test of our understanding, within QCD and the factorization scheme, of single spin asymmetries.

  6. Fluoroquinolone-resistant mutants of Burkholderia cepacia.

    PubMed

    Pope, C F; Gillespie, S H; Pratten, J R; McHugh, T D

    2008-03-01

    Fluoroquinolone-resistant Burkholderia cepacia mutants were selected on ciprofloxacin. The rate of mutation in gyrA was estimated to be 9.6 x 10(-11) mutations per division. Mutations in gyrA conferred 12- to 64-fold increases in MIC, and an additional parC mutation conferred a large increase in MIC (>256-fold). Growth rate, biofilm formation, and survival in water and during drying were not impaired in strains containing single gyrA mutations. Double mutants were impaired only in growth rate (0.85, relative to the susceptible parent).

  7. Electromagnetic Noise Interference and Compatibility

    DTIC Science & Technology

    1975-11-01

    qwuzntitds identiquas, Z sant evident qua 74 charge de 1 ’avion n ’an nerait p~a affectde mazis itn ’an eant pan ainsis d’obord parce qua Zee vitesoen propres ...b) l ’utiLiaatien de peintures d des fins d4’idantification, - C) V existence des antennes cncastrdes, - d) 1 ’existence des pi~ces transparontes...8217antenne. M•$ Lhuroueement it faut ohercher dee peintures , an accordant d ce mot un e#ne trde gintral, qui poseddent des qualitie difficilee d trouver

  8. Development of Metastable Processing Paths for High Temperature Alloys

    DTIC Science & Technology

    1990-06-15

    pair of two-phase O parc lte es fields, NiAI plus Ni 2TiAI and Ni2TiAI plus NiTi [ 4 -61, rapid solidification results are the character of the in...with equilibrium solute partitioning to the solidification of a disordered crystalline ph ~sc with the same composition as the liqiud. Predictions for...the a and P The solidification pross must always involve a sublattices, xA, x’ , xPA, xfl with x1- nj/n + jsubattces 4 4 ,x~, 4 wthx, - nJ(n

  9. Future long-baseline neutrino oscillations: View from Asia

    SciTech Connect

    Hayato, Yoshinari

    2015-07-15

    Accelerator based long-baseline neutrino oscillation experiments have been playing important roles in revealing the nature of neutrinos. However, it turned out that the current experiments are not sufficient to study two major remaining problems, the CP violation in the lepton sector and the mass hierarchy of neutrinos. Therefore, several new experiments have been proposed. Among of them, two accelerator based long-baseline neutrino oscillation experiments, the J-PARC neutrino beam and Hyper-Kamiokande, and MOMENT, have been proposed in Asia. These two projects are reviewed in this article.

  10. Quinolone resistance mechanisms among extended-spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from rivers and lakes in Switzerland.

    PubMed

    Zurfluh, Katrin; Abgottspon, Helga; Hächler, Herbert; Nüesch-Inderbinen, Magdalena; Stephan, Roger

    2014-01-01

    Sixty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from rivers and lakes in Switzerland were screened for individual strains additionally exhibiting a reduced quinolone susceptibility phenotype. Totally, 42 such isolates were found and further characterized for their molecular (fluoro)quinolone resistance mechanisms. PCR and sequence analysis were performed to identify chromosomal mutations in the quinolone resistance-determining regions (QRDR) of gyrA, gyrB, parC and parE and to describe the occurrence of the following plasmid-mediated quinolone resistance genes: qepA, aac-6'-Ib-cr, qnrA, qnrB, qnrC, qnrD and qnrS. The contribution of efflux pumps to the resistance phenotype of selected strains was further determined by the broth microdilution method in the presence and absence of the efflux pump inhibitor phe-arg-β-naphthylamide (PAβN). Almost all strains, except two isolates, showed at least one mutation in the QRDR of gyrA. Ten strains showed only one mutation in gyrA, whereas thirty isolates exhibited up to four mutations in the QRDR of gyrA, parC and/or parE. No mutations were detected in gyrB. Most frequently the amino-acid substitution Ser83→Leu was detected in GyrA followed by Asp87→Asn in GyrA, Ser80→Ile in ParC, Glu84→Val in ParC and Ser458→Ala in ParE. Plasmid-mediated quinolone resistance mechanisms were found in twenty isolates bearing QnrS1 (4/20), AAC-6'-Ib-cr (15/20) and QepA (1/20) determinants, respectively. No qnrA, qnrB, qnrC and qnrD were found. In the presence of PAβN, the MICs of nalidixic acid were decreased 4- to 32-fold. (Fluoro) quinolone resistance is due to various mechanisms frequently associated with ESBL-production in E. coli from surface waters in Switzerland.

  11. Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains

    PubMed Central

    Teatero, Sarah; Patel, Samir N.

    2016-01-01

    Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen. PMID:27559344

  12. Global-local visual processing impacts risk taking behaviors, but only at first

    PubMed Central

    Lim, Stephen Wee Hun; Yuen, Alexander Y. L.; Tong, Eddie M. W.

    2015-01-01

    We investigated the impact of early visual processing on decision-making during unpredictable, risky situations. Participants undertook Navon’s (1977) task and attended to either global letters or local letters only, following which they completed the Balloon Analogue Risk Task (BART). It was observed that global-focused individuals made more balloon pumps during the BART (i.e., took more risk), whereas local-focused individuals took less risk, albeit only initially. The theory of predictive and reactive control systems (PARCS) provides an excellent account of the data. Implications and future directions are discussed. PMID:26379586

  13. IFP: Standing at the intersection between research and industry

    SciTech Connect

    Riviere, C.

    1995-08-01

    Since its formation in 1944, Institut Francais du Petrole (IFP) has pursued a wide range of research and development, training and information activities, servicing the complete chain of petroleum operations, ranging from exploration to the many uses of petroleum products. Standing at the intersection between research and industry, IFP combines basic research and applied industrial research. One of it roles is to contribute to renewing reserves by developing innovative technologies and to ensure the better technico-economic accessibility of discovered reserves. In exploration and reservoir engineering, the R&D program is mainly focused on subjects contributing to the development of methodologies and tools for a better assessment of petroleum resources of sedimentary basins, structural imaging, reservoir characterization, improved oil recovery, well productivity and a more intensive integration of the geosciences: geology/geophysics/reservoir engineering. Environmental protection is a subject of permanent concern at IFP. A part of the program is focused on the restoration of polluted environments. The determination to ensure the optimum dissemination of its scientific and technological patrimony in industry has justified the organization of large-scale industrial action. IFP represents an independent research center unrivaled in Europe. This situation has enabled it to emerge strongly as a leading figure in international scientific and technical circles.

  14. Variability of the wind field in the tropical oceans as observed by satellite sensors

    NASA Astrophysics Data System (ADS)

    Grima, N.; Bentamy, A.; Quilfen, Y.

    1995-12-01

    The wind stress is the primary force driving the tropical oceans from daily to interannual time scales. Conventional measurements from ships of the wind vectors are not available with a sufficient quality regarding data accuracy as well as their coverage. Satellite observations of the surface wind over the sea are now available on a routine basis at the Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), derived from the European Remote Sensing-1 (ERS-1) scatterometer and altimeter and from the radiometer special sensor microwave/imager (SSM/I). More than 3 years of weekly stress fields (1991-1994) with a resolution of one degree in latitude and longitude are produced using an objective analysis method. The accuracy of these gridded winds was evaluated by comparison with TAO buoys in the tropical Pacific area (Riou, 1995). The root mean square differences are of the order of 1.2 m/s and 15 degrees. The greatest differences are observed in the TOGA/COARE region where the wind variability is largest on the weekly scale. The low frequencies (monthly to interannual) of the wind variability are discussed and compared to those obtained from the TAO buoys. In this paper the time and space scales of the sea surface wind are described using a complex EOF analysis. One of the most interesting results is that the weekly averaged wind fields derived from ERS-1 scatterometer are useful to depict a 30-50 day oscillation over the tropical Pacific Ocean.

  15. [Computerization of hospital blood banks in France].

    PubMed

    Daurat, G; Py, J-Y

    2012-11-01

    In France, most blood products are delivered by the établissement francais du sang, directly to the recipients, and hospital blood banks deliver a minor part, but are independent from it. However that may be, hospital blood banks are hazardous activities regarding to recipients, blood products, blood supply of the hospital and regional blood supply. Because of the high risk level, a computerized information system is compulsory for all hospital blood banks, except for those only devoted to vital emergency transfusion. On the field, the integration of computerization in the different processes is very heterogeneous. So, it has been decided to publish guidelines for computerizing hospital blood banks information systems and production management. They have been built according to risk assessment and are intended to minimize those risks. The principle is that all acquisition and processing of data about recipients or blood products and tracking, must be fully computerized and that the result of all manual processes must be checked by computer before proceeding to the next step. The guidelines list the different processes and, for each of them, the functions the software must play. All together, they form the basic level all hospital blood banks should reach. Optional functions are listed. Moreover, the guidelines are also aimed to be a common tool for regional health authorities who supervise hospital blood banks.

  16. Geologic and structural map of eastern Asia

    SciTech Connect

    Letouzey, J.; Sage, L.

    1986-07-01

    A synthesis of the onshore and offshore geologic data of eastern Asia, prepared by the Institut Francais du Petrole (IFP), has allowed the construction of geologic and structural maps for this region. These maps include three color sheets (scale = 1:2.5 million) and three plates of geologic and structural cross sections. Located between lat. 4/sup 0/ and 35/sup 0/N, and long. 106/sup 0/ and 132/sup 0/E, the maps cover the following geographic areas: East and South China Sea, Sulu Sea, West Philippine basin and onshore neighboring terrains, Kyushu and Ryukyu Islands, the China margin, Taiwan Island, Vietnam, North West Borneo, and the Philippines. The maps synthesize seismic interpretations, oil well data, geologic work in south Japan, Taiwan, Borneo, and the Philippines, and recent data published between 1976 and 1985. Twenty-four geologic cross sections (scale = 1:1.25 million, vertical exaggeration x 6) intersect ocean margins, important basins, and the different structural domains. They are based on seismic profiles, well data, and available onshore and offshore geologic data. These cross sections show basement composition and structures, different tectonic and sedimentary domains, and the structure and thickness of different sedimentary deposits (such as age, unconformities, and geologic structures). Maps and cross sections will be published in early 1987.

  17. Oil viscosity limitation on dispersibility of crude oil under simulated at-sea conditions in a large wave tank.

    PubMed

    Trudel, Ken; Belore, Randy C; Mullin, Joseph V; Guarino, Alan

    2010-09-01

    This study determined the limiting oil viscosity for chemical dispersion of oil spills under simulated sea conditions in the large outdoor wave tank at the US National Oil Spill Response Test Facility in New Jersey. Dispersant effectiveness tests were completed using crude oils with viscosities ranging from 67 to 40,100 cP at test temperature. Tests produced an effectiveness-viscosity curve with three phases when oil was treated with Corexit 9500 at a dispersant-to-oil ratio of 1:20. The oil viscosity that limited chemical dispersion under simulated at-sea conditions was in the range of 18,690 cP to 33,400 cP. Visual observations and measurements of oil concentrations and droplet size distributions in the water under treated and control slicks correlated well with direct measurements of effectiveness. The dispersant effectiveness versus oil viscosity relationship under simulated at sea conditions at Ohmsett was most similar to those from similar tests made using the Institut Francais du Pétrole and Exxon Dispersant Effectiveness (EXDET) test methods.

  18. Satisfaction survey in general hospital personnel involved in blood transfusion: implementation of the ISO 9001: 2000 standard.

    PubMed

    Chord-Auger, S; Tron de Bouchony, E; Moll, M C; Boudart, D; Folléa, G

    2004-10-01

    As part of its policy of constant quality improvement, Etablissement francais du sang (EFS) des pays de la Loire (Pays de la Loire Regional Blood Transfusion Centre) carried out a satisfaction survey among the hospital personnel involved in prescribing and using immunohaematological tests and labile blood products (LBP). The polling tool selected by agreement between the Saint Nazaire's hospital management and Quality Assurance (QA) Department was a questionnaire that permitted item rating and free commentary. It addressed the personnel's perception of the quality of erythrocyte immunohaematological (EIH) testing and of the products administered, as well as their perception of the quality of communications with the local EFS. The questionnaire was sent to 26 physicians and 32 senior nurses in 15 hospital departments. The reply rate was 60% and expressed an 85% overall satisfaction level. Dissatisfaction causes were more specifically analysed, the main one involving LBP distribution in emergency situations. A joint undertaking by the EFS and the hospital led to the implementation of corrective measures, including the writing and implementation of a common standard operating procedure for emergency transfusion management. The results obtained demonstrated the feasibility of this type of survey and the interest, to a blood transfusion centre and the hospital personnel involved in transfusion, of assessing their very own perception of service quality.

  19. Pilot scale production of cellulolytic enzymes by Trichoderma reesei

    SciTech Connect

    Warzywoda, M.; Chevron, F.; Ferre, V.; Pourquie, J.

    1983-01-01

    The French substitute fuels program aims at the substitution of part of gasoline by methanol. In order to avoid phase separation of the gasoline-methanol blend, a cosolvant has to be added; one of the most efficient cosolvants is the mixture of acetone and butanol produced by anaerobic acetone-butanol fermentation. The Institut Francais du Petrole is thus implementing a research and development program on the production of acetone butanol from biomass, either sugar crops (fodder beets and Jerusalem artichoke) or lignocellulosic (corn stover and wheat straw). Production of sugars from lignocellulosics is a major part of this program. The enzymatic hydrolysis route, based on Trichoderma reesei cellulolytic enzymes, has been chosen since it does not cause any degradation of C/sub 5/ sugars which are good substrates of the acetone butanol fermentation. Efficient and cheap large-scale production of cellulolytic enzymes is thus a key step in this process. This paper reports on production of cellulases by Trichoderma reesei in a 3-m/sup 3/ pilot fermentor under conditions which should facilitate the scaling-up of the process. 7 references, 2 figures, 2 tables.

  20. Comparison of effectiveness of sub-slab ventilation systems for indoor radon mitigation: A numerical study; Comparaison a l`aide d`un outil numerique de l`efficacite des systemes de ventilation active du sol limitant la penetration du radon dans l`habitat

    SciTech Connect

    Bonnefous, Y.C. |; Gadgil, A.J.; Allard, F.

    1992-04-01

    The functioning of an active sub-slab ventilation system (SVS) has been studied successfully with the help of a previously evaluated numerical model. The parameters explored are the permeability of the sub-slab and the gravel placed beneath it, the amplitude of applied pressure at the installation point of the system and the functioning method: depressurization or pressurization. The mechanisms contributing to the success of the two systems are identified. This numerical study shows that the presence of a layer of gravel beneath the sub-slab considerably improves the performance of the SVS. Considered separately from the extremely permeable sub-slabs, the depressurization systems perform better than the pressurization systems. 17 refs. [Francais] Le fonctionnement des Systemes de Ventilation active du Sol (SVS) a ete etudie a l`aide d`un outil numerique precedemment evalue avec succes. Les parametres explores sont les permeabilites du sol et du gravier place sous plancher bas, l`amplitude de la pression appliquee au point d`installation du systeme, et le mode de fonctionnement: Depressurisation ou Pressurisation. Les mecanismes contribuant au succes des deux systemes sont identifies. Cette etude numerique montre que la presence d`une couche de gravier sous plancher bas ameliore de facon considerable les performances des SVS. Mis a part le cas des sols extremement permeables, les systemes de Depressurisation ont de meilleures performances que les systemes de Pressurisation. 17 refs.

  1. Development of a New Stratigraphic Trap Exploration Using Elastic-Wave Seismic Technology

    SciTech Connect

    Bryan DeVault

    2008-02-05

    Vecta acquired 9 square miles of 9-C seismic data in Mountrail County, North Dakota with the Mission Canyon shoreline as a primary target. Vecta contracted the Institute Francais du Petrole in order to co-develop a more rigorous multicomponent seismic interpretation product. The final interpretation was very unique in that it utilized not only the 9-C seismic data but also the new jointly developed software. A Mission Canyon anomaly was developed in 2006; however, it was of insufficient size to be a commercial target at the time. Therefore, Vecta analyzed the shear data for anisotropy within the Bakken formation and successfully reentered an abandoned producer within the project area and drilled a horizontal leg through the anomalous zones of the middle member of the Bakken formation. The well was open hole completed, swab tested, sand fraced, and swab tested some more. No shows of oil were ever seen from the Bakken formation, but the well yielded considerable amounts of formation water. The well has been abandoned as non-commercial. From the swab tests, one may conclude considerable permeability exists in the formation, thus confirming the utility of the shear wave to detect fractures within the targeted formation.

  2. Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage.

    PubMed

    Richter, Sara N; Leo, Elisabetta; Giaretta, Giulia; Gatto, Barbara; Fisher, L Mark; Palumbo, Manlio

    2006-01-01

    Clerocidin (CL), a diterpenoid natural product, alkylates DNA through its epoxide moiety and exhibits both anticancer and antibacterial activities. We have examined CL action in the presence of topoisomerase IV from Streptococcus pneumoniae. CL promoted irreversible enzyme-mediated DNA cleavage leading to single- and double-stranded DNA breaks at specific sites. Reaction required the diterpenoid function: no cleavage was seen using a naphthalene-substituted analogue. Moreover, drug-induced DNA breakage was not observed using a mutant topoisomerase IV (ParC Y118F) unable to form a cleavage complex with DNA. Sequence analysis of 102 single-stranded DNA breaks and 79 double-stranded breaks revealed an overwhelming preference for G at the -1 position, i.e. immediately 5' of the enzyme DNA scission site. This specificity contrasts with that of topoisomerase IV cleavage with antibacterial quinolones. Indeed, CL stimulated DNA breakage by a quinolone-resistant topoisomerase IV (ParC S79F). Overall, the results indicate that topoisomerase IV facilitates selective irreversible CL attack at guanine and that its cleavage complex differs markedly from that of mammalian topoisomerase II which promotes both irreversible and reversible CL attack at guanine and cytosine, respectively. The unique ability to form exclusively irreversible DNA breaks suggests topoisomerase IV may be a key intracellular target of CL in bacteria.

  3. First results of the spatial and temporal variation of the night sky brightness in the surroundings of Valencia

    NASA Astrophysics Data System (ADS)

    Marco, E.; Morales Rubio, A.; Zamorano, J.; Sánchez de Miguel, A.

    2017-03-01

    In recent years a study of the quality of the night sky in the surroundings of the metropolitan area of Valencia has been done. To achieve this, we used a Sky Quality Meter (SQM-LE) together with a GPS in order to cover a large number of routes from very bright locations near the city of Valencia to very dark areas located more than 100 kilometres away. The objectives of the study were to determine the variation of light pollution with respect to the distance to Valencia, locate areas with a high quality night sky in order to claim for their protection and verify the contribution of smaller towns in the brightness of the sky. Since light pollution also affects biodiversity, we have especially studied its influence on the night sky close to natural parks. Night routes have been done in the interior and vicinity of the Parc de la Calderona, the Albufera and especially the Parc del T ´uria. Our study concludes that these parks are completely degraded and need an urgent protection plan against light pollution. Finally, we present the first results of our fixed detectors SQM-LU scattered throughout the Valencian territory.

  4. The first report of the qnrB19, qnrS1 and aac(6´)-Ib-cr genes in urinary isolates of ciprofloxacin-resistant Escherichia coli in Brazil.

    PubMed

    Paiva, Magna Cristina; Nascimento, Andréa Maria Amaral; Camargo, Ilana Lopes Baratella Cunha; Lima-Bittencourt, Cláudia Iracema; Nardi, Regina Maria Drummond

    2012-08-01

    In this study, we investigated the presence of plasmid-mediated quinolone resistance (PMQR) genes among 101 ciprofloxacin-resistant urinary Escherichia coli isolates and searched for mutations in the quinolone-resistance-determining regions (QRDRs) of the DNA gyrase and topoisomerase IV genes in PMQR-carrying isolates. Eight isolates harboured the qnr and aac(6')-Ib-cr genes (3 qnrS1, 1 qnrB19 and 4 aac(6')-Ib-cr). A mutational analysis of the QRDRs in qnr and aac(6')-Ib-cr-positive isolates revealed mutations in gyrA, parC and parE that might be associated with high levels of resistance to quinolones. No mutation was detected in gyrB. Rare gyrA, parC and parE mutations were detected outside of the QRDRs. This is the first report of qnrB19, qnrS1 and aac(6')-Ib-cr -carrying E. coli isolates in Brazil.

  5. Material issues relating to high power spallation neutron sources

    NASA Astrophysics Data System (ADS)

    Futakawa, M.

    2015-02-01

    Innovative researches using neutrons are being performed at the Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC), in which a mercury target system is installed for MW-class pulse spallation neutron sources. In order to produce neutrons by the spallation reaction, proton beams are injected into the mercury target. At the moment, when the intense proton beam hits the target, pressure waves are generated in mercury because of the abrupt heat deposition. The pressure waves interact with the target vessel, leading to negative pressure that may cause cavitation along the vessel wall, i.e. on the interface between liquid and solid metals. On the other hand, the structural materials are subjected to irradiation damage due to protons and neutrons, very high cycle fatigue damages and so-called "liquid metal embrittlement". That is, the structural materials must be said to be exposed to the extremely severe environments. In the paper, research and development relating to the material issues in the high power spallation neutron sources that has been performed so far at J-PARC is summarized.

  6. Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan

    PubMed Central

    MATAYOSHI, Masanao; KITANO, Takashi; SASAKI, Tetsu; NAKAMURA, Masaji

    2015-01-01

    A total of 349 Salmonella enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) strains, which were isolated between 2008 and 2012 from 349 pigs at two slaughterhouses in Okinawa Prefecture, Japan, were investigated for antimicrobial susceptibility and the presence of antimicrobial resistance genes. All isolates were resistant to at least four antimicrobial agents. The antimicrobial agents for which isolates showed a high incidence of resistance were as follows: ampicillin (100%) and streptomycin (100%), followed by gentamicin (99.7%), oxytetracycline (99.7%), sulfamethoxazole/trimethoprim (99.4%), nalidixic acid (40.1%) and oxolinic acid (40.1%). All isolates were sensitive to cefuroxime, ceftiofur, colistin, fosfomycin, enrofloxacin, orbifloxacin and danofloxacin. The predominant resistance phenotypes and genotypes were: resistance to ampicillin, streptomycin, gentamicin, oxytetracycline and sulfamethoxazole/trimethoprim (58.5%, 204/349) and blaTEM-strA-strB-aadA1-aadA2-aacC2-tet (B)-sul1-sul2-dhfrXII-dhfrXIII (36.1%, 126/349). The quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE of the quinolone-resistant isolates (n=12) showed amino acid substitutions of Ser-83→Phe or Asp-87→Tyr in GyrA and Ser-107→Ala in ParC. To our knowledge, this is the first report on the molecular characterization of antimicrobial resistance among S. Choleraesuis strains in Japan. PMID:25715779

  7. High Resolution Melting Analysis for Rapid Mutation Screening in Gyrase and Topoisomerase IV Genes in Quinolone-Resistant Salmonella enterica

    PubMed Central

    Thong, Kwai Lin

    2014-01-01

    The increased Salmonella resistance to quinolones and fluoroquinolones is a public health concern in the Southeast Asian region. The objective of this study is to develop a high resolution melt curve (HRM) assay to rapidly screen for mutations in quinolone-resistant determining region (QRDR) of gyrase and topoisomerase IV genes. DNA sequencing was performed on 62 Salmonella strains to identify mutations in the QRDR of gyrA, gyrB, parC, and parE genes. Mutations were detected in QRDR of gyrA (n = 52; S83F, S83Y, S83I, D87G, D87Y, and D87N) and parE (n = 1; M438I). Salmonella strains with mutations within QRDR of gyrA are generally more resistant to nalidixic acid (MIC 16 > 256 μg/mL). Mutations were uncommon within the QRDR of gyrB, parC, and parE genes. In the HRM assay, mutants can be distinguished from the wild-type strains based on the transition of melt curves, which is more prominent when the profiles are displayed in difference plot. In conclusion, HRM analysis allows for rapid screening for mutations at the QRDRs of gyrase and topoisomerase IV genes in Salmonella. This assay markedly reduced the sequencing effort involved in mutational studies of quinolone-resistance genes. PMID:25371903

  8. Lattice physics capabilities of the SCALE code system using TRITON

    SciTech Connect

    DeHart, M. D.

    2006-07-01

    This paper describes ongoing calculations used to validate the TRITON depletion module in SCALE for light water reactor (LWR) fuel lattices. TRITON has been developed to provide improved resolution for lattice physics mixed-oxide fuel assemblies as programs to burn such fuel in the United States begin to come online. Results are provided for coupled TRITON/PARCS analyses of an LWR core in which TRITON was employed for generation of appropriately weighted few-group nodal cross-sectional sets for use in core-level calculations using PARCS. Additional results are provided for code-to-code comparisons for TRITON and a suite of other depletion packages in the modeling of a conceptual next-generation boiling water reactor fuel assembly design. Results indicate that the set of SCALE functional modules used within TRITON provide an accurate means for lattice physics calculations. Because the transport solution within TRITON provides a generalized-geometry capability, this capability is extensible to a wide variety of non-traditional and advanced fuel assembly designs. (authors)

  9. Developments of In-Situ SEOP Polarized 3He Neutron Spin Filter in Japan

    NASA Astrophysics Data System (ADS)

    Kira, H.; Sakaguchi, Y.; Oku, T.; Suzuki, J.; Nakamura, M.; Arai, M.; Endoh, Y.; Chang, L. J.; Kakurai, K.; Arimoto, Y.; Ino, T.; Shimizu, H. M.; Kamiyama, T.; Ohoyama, K.; Hiraka, H.; Tsutsumi, K.; Yamada, K.

    2011-06-01

    We launched the polarized 3He neutron spin filters (NSF) project in order to provide neutron polarization for the pulsed neutron beams in Japan. We adopted the in-situ spin exchange optical pumping (SEOP) technique to polarize the nuclear spin of 3He atoms because it has some advantages for our applications. The overall system size is compact and it avoids the problem of the time decay of nuclear spin of 3He thus suppressing the costs of maintenance and providing other advantages [1, 2] with respect to data analysis and quality. In this paper, we performed pulsed neutron beam tests of our compact in-situ SEOP NSF system at the BL10 beamline in the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Research Complex (J-PARC). The polarization of the 3He gas reached was 73 % and a pump-up time constant of 9.5 h was observed. This paper is a status report about the development of in-situ SEOP NSF system for the pulsed beam at J-PARC.

  10. INTERCOMPARISON OF RESULTS FOR A PWR ROD EJECTION ACCIDENT

    SciTech Connect

    DIAMOND,D.J.; ARONSON,A.; JO,J.; AVVAKUMOV,A.; MALOFEEV,V.; SIDOROV,V.; FERRARESI,P.; GOUIN,C.; ANIEL,S.; ROYER,M.E.

    1999-10-01

    This study is part of an overall program to understand the uncertainty in best-estimate calculations of the local fuel enthalpy during the rod ejection accident. Local fuel enthalpy is used as the acceptance criterion for this design-basis event and can also be used to estimate fuel damage for the purpose of determining radiological consequences. The study used results from neutron kinetics models in PARCS, BARS, and CRONOS2, codes developed in the US, the Russian Federation, and France, respectively. Since BARS uses a heterogeneous representation of the fuel assembly as opposed to the homogeneous representations in PARCS and CRONOS, the effect of the intercomparison was primarily to compare different intra-assembly models. Quantitative comparisons for core power, reactivity, assembly fuel enthalpy and pin power were carried out. In general the agreement between methods was very good providing additional confidence in the codes and providing a starting point for a quantitative assessment of the uncertainty in calculated fuel enthalpy using best-estimate methods.

  11. Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.

    PubMed

    Matayoshi, Masanao; Kitano, Takashi; Sasaki, Tetsu; Nakamura, Masaji

    2015-06-01

    A total of 349 Salmonella enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) strains, which were isolated between 2008 and 2012 from 349 pigs at two slaughterhouses in Okinawa Prefecture, Japan, were investigated for antimicrobial susceptibility and the presence of antimicrobial resistance genes. All isolates were resistant to at least four antimicrobial agents. The antimicrobial agents for which isolates showed a high incidence of resistance were as follows: ampicillin (100%) and streptomycin (100%), followed by gentamicin (99.7%), oxytetracycline (99.7%), sulfamethoxazole/trimethoprim (99.4%), nalidixic acid (40.1%) and oxolinic acid (40.1%). All isolates were sensitive to cefuroxime, ceftiofur, colistin, fosfomycin, enrofloxacin, orbifloxacin and danofloxacin. The predominant resistance phenotypes and genotypes were: resistance to ampicillin, streptomycin, gentamicin, oxytetracycline and sulfamethoxazole/trimethoprim (58.5%, 204/349) and blaTEM-strA-strB-aadA1-aadA2-aacC2-tet (B)-sul1-sul2-dhfrXII-dhfrXIII (36.1%, 126/349). The quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE of the quinolone-resistant isolates (n=12) showed amino acid substitutions of Ser-83→Phe or Asp-87→Tyr in GyrA and Ser-107→Ala in ParC. To our knowledge, this is the first report on the molecular characterization of antimicrobial resistance among S. Choleraesuis strains in Japan.

  12. [Effect of Low-concentration Ciprofloxacin on the Nitrification and Nitrifying Microorganisms of Biofilms in Biological Aerated Filter].

    PubMed

    He, Shi; Gu, Chao-chao; Wei, Xin; Huang, Sheng-lin; Liu, Zhen-hong; Xue, Gang; Gao, Pin

    2016-04-15

    Effect of low-concentration ciprofloxacin (CIP) on nitrification and nitrifying microorganisms of biofilms was studied in biological aerated filters (BAF). Quantitative PCR (qPCR) was used to determine the abundance variance of four ciprofloxacin resistance genes (CIP-ARGs) during nitrification in biofilms. The correlations between the abundances of CIP-ARGs and nitrifying microorganisms were also discussed. The results showed that CIP had little influence on the ammonium oxidation process of biofilm microorganisms, whereas inhibition of the nitrite oxidation process was found. The quantitative results of ammonium-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) including Nitrobacter and Nitrospira indicated that the inhibition on the transformation of nitrite was resulted from the inhibition on Nitrobacter and Nitrospira. In addition, little influence of CIP on the relative abundance of aac and qepA in biofilms was found, but the influence on parC and oqxB was great. The abundance of Nitrotacter exhibited significant positive correlation with the abundance of parC. Similar significant correlation was also found between the abundances of Nitrospira and oqxB. It could be speculated that the genetic elements of different nitrifying microorganisms in biofilms possibly carried CIP-ARGs.

  13. Characterization of the Partitioning System of Myxococcus Plasmid pMF1

    PubMed Central

    Feng, Jing; Zhao, Jing-yi; Li, Yue-zhong

    2011-01-01

    pMF1 is the only autonomously replicating plasmid that has been recently identified in myxobacteria. This study characterized the partitioning (par) system of this plasmid. The fragment that significantly increased the retaining stability of plasmids in Myxococcus cells in the absence of selective antibiotics contained three open reading frames (ORFs) pMF1.21-pMF1.23 (parCAB). The pMF1.22 ORF (parA) is homologous to members of the parA ATPase family, with the highest similarity (56%) to the Sphingobium japonicum ParA-like protein, while the other two ORFs had no homologs in GenBank. DNase I footprinting and electrophoretic mobility shift assays showed that the pMF1.23 (parB) product is a DNA-binding protein of iteron DNA sequences, while the product of pMF1.21 (parC) has no binding activity but is able to enhance the DNA-binding activity of ParB to iterons. The ParB protein autogenously repressed the expression of the par genes, consistent with the type Ib par pattern, while the ParC protein has less repressive activity. The ParB-binding iteron sequences are distributed not only near the partitioning gene loci but also along pMF1. These results indicate that the pMF1 par system has novel structural and functional characteristics. PMID:22174771

  14. Elementary Particle Physics and High Energy Phenomena: Final Report for FY2010-13

    SciTech Connect

    Cumalat, John P.; de Alwis, Senarath P.; DeGrand, Thomas A.; DeWolfe, Oliver; Ford, William T.; Hasenfratz, Anna; Mahanthappa, K. T.; Marino, Alysia D.; Nauenberg, Uriel; Smith, James G.; Stenson, Kevin; Wagner, Stephen R.; Zimmerman, Eric D.

    2013-06-27

    The work under this grant consists of experimental, theoretical, and phenomenological research on the fundamental properties of high energy subnuclear particles. The work is conducted at the University of Colorado, the European Organization for Nuclear Research (CERN), the Japan Proton Accelerator Research Complex (J-PARC), Fermi National Accelerator Laboratory (FNAL), SLAC National Accelerator Laboratory (SLAC), Los Alamos National Laboratory (LANL), and other facilities, employing neutrino-beam experiments, test beams of various particles, and proton-proton collider experiments. It emphasizes mass generation and symmetry-breaking, neutrino oscillations, bottom particle production and decay, detector development, supergravity, supersymmetry, superstrings, quantum chromodynamics, nonequilibrium statistical mechanics, cosmology, phase transitions, lattice gauge theory, and anomaly-free theories. The goals are to improve our understanding of the basic building blocks of matter and their interactions. Data from the Large Hadron Collider at CERN have revealed new interactions responsible for particle mass, and perhaps will lead to a more unified picture of the forces among elementary material constituents. To this end our research includes searches for manifestations of theories such as supersymmetry and new gauge bosons, as well as the production and decay of heavy-flavored quarks. Our current work at J-PARC, and future work at new facilities currently under conceptual design, investigate the specifics of how the neutrinos change flavor. The research is integrated with the training of students at all university levels, benefiting both the manpower and intellectual base for future technologies.

  15. Prevalence of first-step mutants among levofloxacin-susceptible isolates of Streptococcus pneumoniae in north Lebanon.

    PubMed

    Dabboussi, Fouad; Allouche, Saria; Mallat, Hassan; Hamze, Monzer

    2013-12-01

    Resistance of Streptococcus pneumoniae to fluoroquinolones arises by stepwise accumulation of spontaneous point mutations in the quinolone-resistance determining regions (QRDRs). Fluoroquinolones treatment of infections caused by first-step mutants (pre-resistant) can lead to the selection of resistant isolates, resulting in treatment failure. First-step mutants cannot however be reliably detected by routine resistance testing. Levofloxacin has been used as a surrogate marker to predict fluoroquinolone susceptibility in clinical laboratories. By use of a PCR followed by pyrosequencing, we examined 45 levofloxacin-susceptible pneumococcal strains [minimal inhibitory concentration (MIC) < 0.5 μg/ml] for first-step parC and parE mutations in the QRDR: 51.2% of isolates were recovered from pulmonary and nasal secretions, 22.2% from blood, 24.4% from ear and eye discharge, and 2.2% from cerebrospinal fluid. The results showed that three strains (6.6%) had first-step parC (Asp83-Asn) or parE (Asp435-Asn) mutations. This test could be useful for some high-risk patients or in national surveys.

  16. Fluoroquinolone resistance in atypical pneumococci and oral streptococci: evidence of horizontal gene transfer of fluoroquinolone resistance determinants from Streptococcus pneumoniae.

    PubMed

    Ip, Margaret; Chau, Shirley S L; Chi, Fang; Tang, Julian; Chan, Paul K

    2007-08-01

    Atypical strains, presumed to be pneumococcus, with ciprofloxacin MICs of > or =4.0 microg/ml and unique sequence variations within the quinolone resistance-determining regions (QRDRs) of the gyrase and topoisomerase genes in comparison with the Streptococcus pneumoniae R6 strain, were examined. These strains were reidentified using phenotypic methods, including detection of optochin susceptibility, bile solubility, and agglutination by serotype-specific antisera, and genotypic methods, including detection of pneumolysin and autolysin genes by PCR, 16S rRNA sequencing, and multilocus sequence typing (MLST). The analysis based on concatenated sequences of the six MLST loci distinguished the "atypical" strains from pneumococci, and these strains clustered closely with S. mitis. However, all these strains and five of nine strains from the viridans streptococcal group possessed one to three gyrA, gyrB, parC, and parE genes whose QRDR sequences clustered with those of S. pneumoniae, providing evidence of horizontal transfer of the QRDRs of the gyrase and topoisomerase genes from pneumococci into viridans streptococci. These genes also conferred fluoroquinolone resistance to viridans streptococci. In addition, the fluoroquinolone resistance determinants of 32 well-characterized Streptococcus mitis and Streptococcus oralis strains from bacteremic patients were also compared. These strains have unique amino acid substitutions in GyrA and ParC that were distinguishable from those in fluoroquinolone-resistant pneumococci and the "atypical" isolates. Both recombinational events and de novo mutations play an important role in the development of fluoroquinolone resistance.

  17. Chilled packing systems for fruit flies (Diptera: Tephritidae) in the sterile insect technique.

    PubMed

    Hernández, Emilio; Escobar, Arseny; Bravo, Bigail; Montoya, Pablo

    2010-01-01

    We evaluated three packing systems (PARC boxes, "GT" screen towers and "MX" screen towers) for the emergence and sexual maturation of sterile fruit flies, at three adult fly densities (1, 1.2 and 1.3 fly/cm²) and three food types. At the lowest density, results showed no significant differences in the longevity and flight ability of adult Anastrepha ludens (Loew) and Anastrepha obliqua Macquart among the three packing systems. Higher densities resulted in a decrease in these parameters. In the evaluation of the three food types, no significant differences were found either on longevity or flight ability of A. ludens. However, the greatest longevity for both sexes A. obliqua was obtained with commercial powdered Mb® and the mix of sugar, protein and corn starch on paper (SPCP) food types. The highest value for flight ability in A. obliqua males was obtained with powdered Mb® and SPCP food types, and for females with Mb® powdered food. Our data indicated that GT and MX screen tower packing systems are an alternative to the PARC boxes, since they were suitable for adult fly sexual maturation without any harm to their longevity or flight ability. The tested foods were equivalent in both fruit fly species, with the exception of the agar type for A. obliqua, which yielded the lowest biological parameters evaluated. Our results contribute to the application of new methods for the packing and release of sterile flies in large-scale programs.

  18. Fluoroquinolone Resistance in Penicillin-resistant Streptococcus pneumoniae Clones, Spain

    PubMed Central

    Balsalobre, Luz; Ardanuy, Carmen; Fenoll, Asunción; Pérez-Trallero, Emilio; Liñares, Josefina

    2004-01-01

    Among 2,882 Streptococcus pneumoniae sent to the Spanish Reference Laboratory during 2002, 75 (2.6%) were ciprofloxacin-resistant. Resistance was associated with older patients (3.9% in adults and 7.2% in patients >65 years of age), with isolation from noninvasive sites (4.3% vs. 1.0%), and with penicillin and macrolide resistance. Among 14 low-level resistant (MIC 4–8 µg/mL) strains, 1 had a fluoroquinolone efflux phenotype, and 13 showed single ParC changes. The 61 high-level ciprofloxacin-resistant (MIC >16 µg/mL) strains showed either two or three changes at ParC, ParE, and GyrA. Resistance was acquired either by point mutation (70 strains) or by recombination with viridans streptococci (4 strains) at the topoisomerase II genes. Although 36 pulsed-field gel electrophoresis patterns were observed, 5 international multiresistant clones (Spain23F-1, Spain6B-2, Spain9V-3, Spain14-5 and Sweden15A-25) accounted for 35 (46.7%) of the ciprofloxacin-resistant strains. Continuous surveillance is needed to prevent the dissemination of these clones. PMID:15504260

  19. Strange Particles and Heavy Ion Physics

    SciTech Connect

    Bassalleck, Bernd; Fields, Douglas

    2016-04-28

    This very long-running grant has supported many experiments in nuclear and particle physics by a group from the University of New Mexico. The gamut of these experiments runs from many aspects of Strangeness Nuclear Physics, to rare Kaon decays, to searches for exotic Hadrons such as Pentaquark or H-Dibaryon, and finally to Spin Physics within the PHENIX collaboration at RHIC. These experiments were performed at a number of laboratories worldwide: first and foremost at Brookhaven National Lab (BNL), but also at CERN, KEK, and most recently at J-PARC. In this Final Technical Report we summarize progress and achievements for this award since our last Progress Report, i.e. for the period of fall 2013 until the award’s termination on November 30, 2015. The report consists of two parts, representing our two most recent experimental efforts, participation in the Nucleon Spin Physics program of the PHENIX experiment at RHIC, the Relativistic Heavy Ion Collider at BNL – Task 1, led by Douglas Fields; and participation in several Strangeness Nuclear Physics experiments at J-PARC, the Japan Proton Accelerator Research Center in Tokai-mura, Japan – Task 2, led by Bernd Bassalleck.

  20. PREFACE: 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment

    NASA Astrophysics Data System (ADS)

    Suzuki, Atsuto; Nishikawa, Koichiro

    2011-07-01

    "Neutrino physics is largely an art of learning a great deal by observing nothing" (Haim Harari, 1988) was our general understanding of the field for the ~25 years previous. A new neutrino era was abruptly brought from outer space by a burst of SN1987A neutrinos. The detection of neutrinos from SN1987A gave a new impetus to neutrino research. As we know, new discoveries of neutrinos have since been made. Neutrinos were no longer mysterious, but attained particle citizenship. Giant liquid argon charge imaging experiments have the prospect of opening the door to the second new era in neutrino physics. The coming era would provoke not evolution, but revolution in particle physics. However, paving the way for the new era requires not evolutionary, but revolutionary detector developments. I hope this workshop will be conducive to reaping a rich harvest from its activities. In 1993, Professor Carlo Rubbia presented "The Renaissance of Experimental Neutrino Physics" in which he discussed various possibilities of shooting neutrino beams from CERN towards Gran Sasso, Super-Kamiokande at Kamioka and DUMAND in Hawaii. Now KEK hopes to shoot neutrino beams from J-PARC to Kamioka, Okinoshima, Korea and Gran Sasso. Signature Atsuto SuzukiDirector General, KEK J-PARC has moved into a new phase of operation. The commissioning of the accelerator complex and experiment facilities has begun, and it is urgent to attain initial design performance as soon as possible. For the immediate future, KEK has a 5 year plan. The plan includes the upgrade of the J-PARC accelerator to a multi-Mega-Watt facility, and detector R&Ds to form the basis for a next step in the neutrino experiment. One of the main issues of the future neutrino experiment will be the search for CP violation in neutrino oscillation, which demands much more precision than studying neutrino oscillation or non-zero theta13. This naturally requires a very massive detector with higher precision than presently available

  1. The 1994 EUROMET collection of micrometeorites at Cap-Prudhomme, Antarctica

    NASA Astrophysics Data System (ADS)

    Maurette, M.; Immel, G.; Engrand, C.; Kurat, G.; Pillinger, C. T.

    1994-07-01

    Advance funding from IFRTP (Institut Francais pour la Recherche et pour la Technique Polaire) for micrometeorite collection at Cap-Prudhomme has allowed construction of a new micrometeorite 'factory,' conceived to greatly reduce contamination of the ultraclean ice by our activities. The potential problems include fly ash, rust grains, fuel spills 'sticking to the shoes,' and trace elements from the plasticizers used in plastic tubing. In the new factory, intended to produce and then cycle 10-15 tons of melt ice water per day, all parts exposed to water were replaced by either stainless steel or teflon. After examination with a microscope and their transfer into teflon and or glass vials, all samples were frozen the day of their collection. The factory operated from December 15, 1993, through February 6, 1994. Problems included injuries as well as very bad weather conditions, characterized by both the heaviest snow falls observed and unexpected gusts from a blizzard. Also, several new components of the factory did not function properly under the extreme conditions of Antarctica. Our major objective was to obtain the 'cleanest' and 'purest' 25-50 microns micrometeorites ever collected in Antarctica, for comparison with stratospheric Interplanetary Dust Particles (IDPs). We could not fulfill this premise, but we recovered the best 100-400-micron-size fraction of 'giant' micrometeorites ever collected on Earth. Our 26 daily collections are listed,refering to an 'index of quality.' Aliquots of these daily collections will be distributed to major institutions in Austria, England, the U.S.A., and Japan, to be preserved for future generations. The Antarctica ice sheet is truly a gigantic, ultraclean, and inexhaustible micrometeorite collector, but it is very tricky to recover 'ultraclean' micrometeorites from it.

  2. [Presidential address at the 20th Journees sur la Fertilite et l'Orthogenie].

    PubMed

    Dourlen-rollier, A M

    1993-01-01

    Recollections of the author's early experiences in French family planning and reflections on the ethical issues and legal status of new fertility technologies are the major topics of this address. The group that was to become le Mouvement francais pour le Planning Familial (MFPF) was founded in 1956 by the author and others and opened its first family planning center in 1961, before contraception became legal. Despite opposition from physicians and Catholic clergy, the MFPF operated 100 centers serving over 100,000 clients by 1965. In 1969 the MFPF began a study of abortion. Despite legalization, the controversy concerning the legitimacy of abortion has not subsided. More recently, the practices of artificial insemination with donor sperm, in vitro fertilization, surrogate mothers, and other medically assisted fertility technologies have raised moral, ethical, and legal questions for all societies. The questions range from the legitimacy of gamete donation to the status of unused embryos. The dissociation of different stages of the reproductive process affects concepts of filiation, paternity and maternity. In the absence of appropriate legislation, it has been left largely to the courts to create a new body of law at this frontier. The review of legislation in France, elsewhere in Europe, and in the U.S. concerning contested filiation in cases of artificial insemination, the legitimacy of insemination of a woman after the death of her spouse, the preservation and donation of embryos, surrogate motherhood, the child's rights to information about his biological parents, and other questions indicate that no consensus has yet emerged concerning the admissibility and legitimacy of specific practices. It would be highly desirable for the European countries to adopt a common legislation in these areas.

  3. Characterization of Saharan dust properties transported towards Europe in the frame of the FENNEC project: a case study

    NASA Astrophysics Data System (ADS)

    Marnas, F.; Chazette, P.; Flamant, C.; Royer, P.; Sodemman, H.; Derimian, Y.

    2012-04-01

    In the framework of the FENNEC experiment (6 to 30 June 2011) an effort has been dedicated to characterize Saharan dust plumes transported towards southern Europe. Hence, a multi instrumented field campaign has been conducted. Ground based nitrogen Raman LIDAR (GBNRL) has been deployed in southern Spain close to Marbella, simultaneously with airborne lidar (AL) performing measurements over both the tropical Atlantic Ocean and the western Africa (from 2 to 23 June). The GBNRL was equipped with co-polar and cross-polar channels to perform continuous measurements of the dust aerosols trapped in the troposphere. It was developed by LSCE with the support of the LEOSPHERE Company. The French FALCON 20 research aircraft operated by SAFIRE (Service des Avions Francais Instrumentés pour la Recherche en Environnement) carried the AL Leandre Nouvelle Generation (LNG) as well as a dropsonde releasing system and radiometers. A major, one week long, dust event has been sampled over Spain from 25 June to 1 July with high optical depth (>0.5 at 355nm) and particular depolarization ratios (15 to 25%). Backtrajectory studies suggest that the dust particles observed were from dust uplifts that occurred in Southern Morocco and Northern Mauritania. The event has been also documented 3 days before by the AL flying over Mauritania. AERONET sunphotometer measurements of aerosol properties, along the dust plume transport path appear to be coherent with both the lidar and the backtrajectory analysis. These analysis exhibit a likely major contribution from the Western Sahara sources to the Southern Europe. Such a contribution may impact the visibility and then the airtrafic, modify the tropospheric chemistry, and add nutrients to both the Mediterranean Sea and the continental surfaces. It can also affect the health of European populations. We will present strategy of the experiment and the case study built from measurements performed at the end of June.

  4. Agriculture: A source of raw materials for industrial purposes the French strategy

    SciTech Connect

    Mauguin, P.; Gaouyer, J.P.; Labrousse, S.

    1995-11-01

    Creating new value-added products from agricultural and forestry biomass can present opportunities for diversifying industry, preserving agricultural activities and reinvigorating exploitation of forests. Stimulating new markets for agriculture and forestry products is strategically important for France, in order to cushion the effects of the reform of the European Common Policy (CAP), while maintaining the commitments assessed at the Rio Coference. The promotion of new markets should constitute a major vector for rural development, by marking use of agricultural lands no longer needed for food crops due to the glut of foodstuffs on the market. In the next few years, energy uses of biomass should help hold down greenhouse gas emissions, by regulating and storing CO{sub 2}. For each of these markets, whether for energy uses (solid, liquid or gaseous fuels) or for other applications, the first priority is to match prices and specifications of the fossil fuels that are to be deplaced, with minimum impact on the environment. To match these goals, the French government has launched a new research group, Agriculture for Chemicals and Energy (AGRICE). AGRICE has been set up for a renewable five years period. Its members are: Agriculture, Industry, Research and Environment departments; the Institut National de la Recherche Agronomique (INRA), the Institut Francais due Petrole (IFP), the French Agency for Environment and Energy (Ademe); Wheat producers, Beet growers, and oil seed producers; and Rhone Poulenc (chemicals), TOTAL (oil company). In 1995, AGRICE will have a 40 Millions FFrancs from public funds, supplemented by 25 Millions FFrancs from business and trade groups.

  5. Emergence and spread of O16-ST131 and O25b-ST131 clones among faecal CTX-M-producing Escherichia coli in healthy individuals in Hunan Province, China

    PubMed Central

    Zhong, Yi-Ming; Liu, Wen-En; Liang, Xiang-Hui; Li, Yan-Ming; Jian, Zi-Juan; Hawkey, Peter M.

    2015-01-01

    Objectives The objectives of this study were to determine CTX-M-producing Escherichia coli ST131 strain prevalence in stool specimens from healthy subjects in central China and to molecularly characterize clonal groups. Methods From November 2013 to January 2014, stool specimens from healthy individuals in Hunan Province were screened for ESBL-producing E. coli using chromogenic medium and CTX-M genotypes and phylogenetic groups were determined. ST131 clonal groups were detected by PCR and characterized for antibiotic resistance, fimH, gyrA and parC alleles, plasmid-mediated quinolone resistance determinants, virulence genotypes and PFGE patterns. Results Among 563 subjects, 287 (51.0%) exhibited the presence of faecal ESBL-producing E. coli, all of which produced CTX-M enzymes. The most common CTX-M genotypes were CTX-M-14 (48.4%), CTX-M-15 (27.5%) and CTX-M-27 (15.0%). Of the 287 CTX-M-producing isolates, 32 (11.1%) belonged to the ST131 clone. O16-ST131 isolates were dominant (75%) and contained the fimH41 allele. The remaining eight (25%) ST131 isolates were of the O25b subgroup and contained fimH30 or fimH41. Ciprofloxacin resistance was found in 100% of the O25b-ST131 isolates, whereas only 8% of the O16-ST131 isolates were resistant. All of the O25b-ST131 isolates except one showed gyrA1AB and parC1aAB mutations; most of the O16-ST131 isolates had gyrA1A and parC1b mutations. The virulence genotypes of O16-ST131 resembled those of the O25b-ST131 isolates. The 32 ST131 isolates formed one large group at the 64% similarity level. They comprised 15 PFGE groups (defined at ≥85% similarity). Conclusions O16-ST131 isolates have emerged as the predominant type of ST131 isolate in faecal CTX-M-producing E. coli in healthy individuals in China. PMID:25957581

  6. Cesiated surface H- ion source: optimization studies

    NASA Astrophysics Data System (ADS)

    Ueno, Akira

    2017-01-01

    The H- ion beam intensity required for high-energy and high-intensity proton accelerators is continuously increasing. The required 95%-beam transverse normalized root mean square emittance (ɛ 95%rnmsx/y ) of the beam is around 0.25 πmm mrad for all accelerators. The Japan Proton Accelerator Complex (J-PARC) 400 MeV linear accelerator (LINAC) succeeded in accelerating the world’s highest-class H- ion beam of 50 mA with a cesiated RF-driven H- ion source. This was achieved by increasing the beam brightness through the following measures: (1) 45°-tapered plasma electrode (PE) with a 16 mm thickness to increase beam intensity by 56%, (2) continuous-wave igniter plasma driven by 50 W 30 MHz RF to reduce hydrogen pressure in the plasma chamber (PCH) by 50% and beam loss in low-energy beam transport by 12%, compared with that by the commonly used 300 W 13.56 MHz RF, (3) axial magnetic-field correction around the PE beam aperture to increase beam intensity by a maximum of 15%, (4) operation at a low PE temperature (T PE) of about 70 °C to reduce ɛ 95%nrmsx/y by 27%, (5) suitable beam apertures of the plasma and the extraction electrodes to increase beam intensity by a maximum of 7% and to reduce ɛ 95%nrmsx/y by more than 4%, (6) argon/nitrogen elimination and 39% filter-field reduction to reduce ɛ 95%nrmsx/y by 9% and the required 2 MHz RF power by around 30%, (7) eight-hours conditioning with a 50 kW 2 MHz RF and a 5% (1 ms × 50 Hz) duty factor to reduce ɛ 95%nrmsx/y by 15%, and (8) slight water molecules (H2Os) feeding in hydrogen to avoid ɛ 95%nrmsx/y increase by 72% and divergence angle expansion by 50%. In the studies, we investigated principally the 66 mA H- ion beams extracted from the source in order to achieve a 50 mA beam at the J-PARC LINAC exit regardless of the beam’s brightness. Consequently, the source can produce the required beam for a 60 mA J-PARC LINAC operation, since the world’s brightest-class beam with the ɛ 95%nrmsx/y of 0.23

  7. Performance enhancement of plasmonics silicon solar cells using Al2O3/In NPs/TiO2 antireflective surface coating

    NASA Astrophysics Data System (ADS)

    Ho, Wen-Jeng; Lee, Yi-Yu; Lin, Chi-He; Yeh, Chien-Wu

    2015-11-01

    In this study, the enhancement of silicon solar cell photovoltaic performance by means of indium nanoparticles (In NPs) deposited on the TiO2 space layer and capped with an Al2O3 antireflective layer is demonstrated. The impressive performance enhancement is attributed to the plasmonic scattering of broadband light which occurs as a result of the Al2O3/In NPs/TiO2 antireflective coating (PARC) surface structure. The optical reflectance, photovoltaic current-voltage (I-V), external quantum efficiency (EQE), and photovoltaic performance as a function of the incident angles are measured and compared. The experimental results show that the reflectance decreases with increasing TiO2 thickness and that the lowest reflection point of the spectrum was red-shifted by the use of a PARC surface structure. EQE was significantly enhanced between 400 and 1050 nm wavelengths and much high EQE of 85% were observed for the cell with In NPs embedded in the 65-nm Al2O3/20 nm TiO2 layer structure. In comparison to a bare reference solar cell, an efficiency enhancement of 54.47% (from 10.96% to 16.93%) and a short-circuit current density enhancement of 52.83% (from 26.10 to 39.89 mA/cm2) were obtained for the cell with a 65-nm Al2O3/In NPs/20-nm TiO2 antireflection structure under normal incident illumination. In addition, for incident angles from 0° to 15°, the 0.78% decrease in conversion efficiency (from 16.71% to 16.58%) of the cell with the PARC surface structure was less than the 3.28% (from 13.86% to 13.49%) decrease of the cell with 65-nm Al2O3/20-nm TiO2 double layer antireflective coating (DL-ARC) due to the plasmonic scattering of broadband light.

  8. Co-Extrusion: Advanced Manufacturing for Energy Devices

    SciTech Connect

    Cobb, Corie Lynn

    2016-11-18

    The development of mass markets for large-format batteries, including electric vehicles (EVs) and grid support, depends on both cost reductions and performance enhancements to improve their economic viability. Palo Alto Research Center (PARC) has developed a multi-material, advanced manufacturing process called co-extrusion (CoEx) to remove multiple steps in a conventional battery coating process with the potential to simultaneously increase battery energy and power density. CoEx can revolutionize battery manufacturing across most chemistries, significantly lowering end-product cost and shifting the underlying economics to make EVs and other battery applications a reality. PARC’s scale-up of CoEx for electric vehicle (EV) batteries builds on a solid base of experience in applying CoEx to solar cell manufacturing, deposition of viscous ceramic pastes, and Li-ion battery chemistries. In the solar application, CoEx has been deployed commercially at production scale where multi-channel CoEx printheads are used to print viscous silver gridline pastes at full production speeds (>40 ft/min). This operational scale-up provided invaluable experience with the nuances of speed, yield, and maintenance inherent in taking a new technology to the factory floor. PARC has leveraged this experience, adapting the CoEx process for Lithium-ion (Li-ion) battery manufacturing. To date, PARC has worked with Li-ion battery materials and structured cathodes with high-density Li-ion regions and low-density conduction regions, documenting both energy and power performance. Modeling results for a CoEx cathode show a path towards a 10-20% improvement in capacity for an EV pouch cell. Experimentally, we have realized a co-extruded battery structure with a Lithium Nickel Manganese Cobalt (NMC) cathode at print speeds equivalent to conventional roll coating processes. The heterogeneous CoEx cathode enables improved capacity in thick electrodes at higher C-rates. The proof-of-principle coin cells

  9. Characteristics of Quinolone Resistance in Escherichia coli Isolates from Humans, Animals, and the Environment in the Czech Republic

    PubMed Central

    Röderova, Magdalena; Halova, Dana; Papousek, Ivo; Dolejska, Monika; Masarikova, Martina; Hanulik, Vojtech; Pudova, Vendula; Broz, Petr; Htoutou-Sedlakova, Miroslava; Sauer, Pavel; Bardon, Jan; Cizek, Alois; Kolar, Milan; Literak, Ivan

    2017-01-01

    Escherichia coli is a common commensal bacterial species of humans and animals that may become a troublesome pathogen causing serious diseases. The aim of this study was to characterize the quinolone resistance phenotypes and genotypes in E. coli isolates of different origin from one area of the Czech Republic. E. coli isolates were obtained from hospitalized patients and outpatients, chicken farms, retailed turkeys, rooks wintering in the area, and wastewaters. Susceptibility of the isolates grown on the MacConkey agar with ciprofloxacin (0.05 mg/L) to 23 antimicrobial agents was determined. The presence of plasmid-mediated quinolone resistance (PMQR) and ESBL genes was tested by PCR and sequencing. Specific mutations in gyrA, gyrB, parC, and parE were also examined. Multilocus sequence typing and pulsed-field gel electrophoresis were performed to assess the clonal relationship. In total, 1050 E. coli isolates were obtained, including 303 isolates from humans, 156 from chickens, 105 from turkeys, 114 from the rooks, and 372 from wastewater samples. PMQR genes were detected in 262 (25%) isolates. The highest occurrence was observed in isolates from retailed turkey (49% of the isolates were positive) and inpatients (32%). The qnrS1 gene was the most common PMQR determinant identified in 146 (56%) followed by aac(6′)-Ib-cr in 77 (29%), qnrB19 in 41 (16%), and qnrB1 in 9 (3%) isolates. All isolates with high level of ciprofloxacin resistance (>32 mg/L) carried double or triple mutations in gyrA combined with single or double mutations in parC. The most frequently identified substitutions were Ser(83)Leu; Asp(87)Asn in GyrA, together with Ser(80)Ile, or Glu(84)Val in ParC. Majority of these isolates showed resistance to beta-lactams and multiresistance phenotype was found in 95% isolates. Forty-eight different sequence types among 144 isolates analyzed were found, including five major clones ST131 (26), ST355 (19), ST48 (13), ST95 (10), and ST10 (5). No isolates

  10. Fitness of Streptococcus pneumoniae Fluoroquinolone-Resistant Strains with Topoisomerase IV Recombinant Genes▿

    PubMed Central

    Balsalobre, Luz; de la Campa, Adela G.

    2008-01-01

    The low prevalence of ciprofloxacin-resistant (Cpr) Streptococcus pneumoniae isolates carrying recombinant topoisomerase IV genes could be attributed to a fitness cost imposed by the horizontal transfer, which often implies the acquisition of larger-than-normal parE-parC intergenic regions. A study of the transcription of these genes and of the fitness cost for 24 isogenic Cpr strains was performed. Six first-level transformants were obtained either with PCR products containing the parC quinolone resistance-determining regions (QRDRs) of S. pneumoniae Cpr mutants with point mutations or with a PCR product that includes parE-QRDR-ant-parC-QRDR from a Cpr Streptococcus mitis isolate. The latter yielded two strains, T6 and T11, carrying parC-QRDR and parE-QRDR-ant-parC-QRDR, respectively. These first-level transformants were used as recipients in further transformations with the gyrA-QRDR PCR products to obtain 18 second-level transformants. In addition, strain Tr7 (which contains the GyrA E85K change) was used. Reverse transcription-PCR experiments showed that parE and parC were cotranscribed in R6, T6, and T11; and a single promoter located upstream of parE was identified in R6 by primer extension. The fitness of the transformants was estimated by pairwise competition with R6 in both one-cycle and two-cycle experiments. In the one-cycle experiments, most strains carrying the GyrA E85K change showed a fitness cost; the exception was recombinant T14. In the two-cycle experiments, a fitness cost was observed in most first-level transformants carrying the ParC changes S79F, S79Y, and D83Y and the GyrA E85K change; the exceptions were recombinants T6 and T11. The results suggest that there is no impediment due to a fitness cost for the spread of recombinant Cpr S. pneumoniae isolates, since some recombinants (T6, T11, and T14) exhibited an ability to compensate for the cost. PMID:18160515

  11. Production and decay of charmed baryons

    NASA Astrophysics Data System (ADS)

    Hosaka, Atsushi; Hiyama, Emiko; Kim, SangHo; Kim, Hyun-Chul; Nagahiro, Hideko; Noumi, Hiroyuki; Oka, Makoto; Shirotori, Kotaro; Yoshida, Tetsuya; Yasui, Shigehiro

    2016-10-01

    In this paper, we discuss reactions involving charmed baryons to explore their unique features. A well known phenomenon, the separation of the two internal motions of the ρ and λ types of a three-quark system is revisited. First we discuss the mass spectrum of low lying excitations as function of the heavy quark mass, smoothly connecting the SU (3) and heavy quark limits. The properties of these modes can be tested in the production and decay reactions of the baryons. For production, we consider a one step process which excites dominantly λ modes. We find abundant production rates for some of the excited states. For decay, we study a pion emission process which provides a clean tool to test the structure of heavy quark systems due to the well controlled low energy dynamics of pions and quarks. Both production and decay of charmed baryons are issues for future experiments at J-PARC.

  12. Automated Derivation of Complex System Constraints from User Requirements

    NASA Technical Reports Server (NTRS)

    Muery, Kim; Foshee, Mark; Marsh, Angela

    2006-01-01

    International Space Station (ISS) payload developers submit their payload science requirements for the development of on-board execution timelines. The ISS systems required to execute the payload science operations must be represented as constraints for the execution timeline. Payload developers use a software application, User Requirements Collection (URC), to submit their requirements by selecting a simplified representation of ISS system constraints. To fully represent the complex ISS systems, the constraints require a level of detail that is beyond the insight of the payload developer. To provide the complex representation of the ISS system constraints, HOSC operations personnel, specifically the Payload Activity Requirements Coordinators (PARC), manually translate the payload developers simplified constraints into detailed ISS system constraints used for scheduling the payload activities in the Consolidated Planning System (CPS). This paper describes the implementation for a software application, User Requirements Integration (URI), developed to automate the manual ISS constraint translation process.

  13. Neutrino nuclear responses for double beta decays and astro neutrinos by charge exchange reactions

    NASA Astrophysics Data System (ADS)

    Ejiri, Hiroyasu

    2014-09-01

    Neutrino nuclear responses are crucial for neutrino studies in nuclei. Charge exchange reactions (CER) are shown to be used to study charged current neutrino nuclear responses associated with double beta decays(DBD)and astro neutrino interactions. CERs to be used are high energy-resolution (He3 ,t) reactions at RCNP, photonuclear reactions via IAR at NewSUBARU and muon capture reactions at MUSIC RCNP and MLF J-PARC. The Gamow Teller (GT) strengths studied by CERs reproduce the observed 2 neutrino DBD matrix elements. The GT and spin dipole (SD) matrix elements are found to be reduced much due to the nucleon spin isospin correlations and the non-nucleonic (delta isobar) nuclear medium effects. Impacts of the reductions on the DBD matrix elements and astro neutrino interactions are discussed.

  14. Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009▿

    PubMed Central

    Rodríguez-Avial, Iciar; Ramos, Belén; Ríos, Esther; Cercenado, Emilia; Ordobás, María; Sanz, Juan Carlos

    2011-01-01

    Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n = 32 isolates), 19A (n = 4 isolates), 7F (n = 3 isolates), 9V (n = 2 isolates), 10A (n = 1 isolate), 19F (n = 1 isolate), 6B (n = 1 isolate), and nontypeable (n = 1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden15A-25 clone. Levofloxacin resistance was also detected among multiresistant (ST27619A, Spain9V-ST156, ST8819F, and ST15426B) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST120119A, and ST263910A) clones. PMID:21383091

  15. A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam

    PubMed Central

    Terada, K.; Ninomiya, K.; Osawa, T.; Tachibana, S.; Miyake, Y.; Kubo, M. K.; Kawamura, N.; Higemoto, W.; Tsuchiyama, A.; Ebihara, M.; Uesugi, M.

    2014-01-01

    The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (106 s−1 for a momentum of 60 MeV/c), enabled us to pioneer a new frontier in analytical sciences. Here, we report a non-destructive elemental analysis using µ− capture. Controlling muon momentum from 32.5 to 57.5 MeV/c, we successfully demonstrate a depth-profile analysis of light elements (B, C, N, and O) from several mm-thick layered materials and non-destructive bulk analyses of meteorites containing organic materials. Muon beam analysis, enabling a bulk analysis of light to heavy elements without severe radioactivation, is a unique analytical method complementary to other non-destructive analyses. Furthermore, this technology can be used as a powerful tool to identify the content and distribution of organic components in future asteroidal return samples. PMID:24861282

  16. Hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2013-02-01

    The HARP and NA61/SHINE hadroproduction experiments as well as their implications for neutrino physics are discussed. HARP measurements have already been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First measurements released recently by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment. Both HARP and NA61/SHINE experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  17. Fixed-target hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2015-08-01

    Results from fixed-target hadroproduction experiments (HARP, MIPP, NA49 and NA61/SHINE) as well as their implications for cosmic ray and neutrino physics are reviewed. HARP measurements have been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve predictions of the muon yields in EAS and of the atmospheric neutrino fluxes as well as to help in the optimization of neutrino factory and super-beam designs. Recent measurements released by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment and for interpretation of EAS data. These hadroproduction experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  18. HARP and NA61 (SHINE) hadron production experiments

    SciTech Connect

    Popov, Boris A.

    2009-11-25

    The hadroproduction experiments HARP and NA61 (SHINE) as well as their implications for neutrino physics are discussed. Recent HARP measurements have already been used for precise predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First preliminary data from NA61 are of significant importance for a precise prediction of a new neutrino beam at J-PARC to be used for the first stage of the T2K experiment. Both HARP and NA61 provide a large amount of input for validation and tuning of hadroproduction models in Monte-Carlo generators.

  19. A comparative study of turbulence models in predicting hypersonic inlet flows

    NASA Technical Reports Server (NTRS)

    Kapoor, Kamlesh

    1993-01-01

    A computational study has been conducted to evaluate the performance of various turbulence models. The NASA P8 inlet, which represents cruise condition of a typical hypersonic air-breathing vehicle, was selected as a test case for the study; the PARC2D code, which solves the full two dimensional Reynolds-averaged Navier-Stokes equations, was used. Results are presented for a total of six versions of zero- and two-equation turbulence models. Zero-equation models tested are the Baldwin-Lomax model, the Thomas model, and a combination of the two. Two-equation models tested are low-Reynolds number models (the Chien model and the Speziale model) and a high-Reynolds number model (the Launder and Spalding model).

  20. The New Muon g₋2 experiment at Fermilab

    SciTech Connect

    Venanzoni, Graziano

    2016-06-02

    There is a long standing discrepancy between the Standard Model prediction for the muon g-2 and the value measured by the Brookhaven E821 Experiment. At present the discrepancy stands at about three standard deviations, with a comparable accuracy between experiment and theory. Two new proposals -- at Fermilab and J-PARC -- plan to improve the experimental uncertainty by a factor of 4, and it is expected that there will be a significant reduction in the uncertainty of the Standard Model prediction. I will review the status of the planned experiment at Fermilab, E989, which will analyse 21 times more muons than the BNL experiment and discuss how the systematic uncertainty will be reduced by a factor of 3 such that a precision of 0.14 ppm can be achieved.