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Sample records for parc electronucleaire francais

  1. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs "vouloir,""pouvoir," and "venir,"…

  2. Le Francais Moderne: Part I, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Moderne: Part 1" focus on the development of vocabulary and mastery of grammatical structures. The formation of the passe compose with "avoir," object pronouns, the present tense of regular "-ir" verbs, and the irregular verbs…

  3. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  4. Systematic in J-PARC/Hyper-K

    SciTech Connect

    Minamino, Akihiro

    2015-05-15

    The Hyper-Kamiokande (Hyper-K) detector is a next generation underground water Chrenkov detector. The J-PARC to Hyper-K experiment has good potential for precision measurements of neutrino oscillation parameters and discovery reach for CP violation in the lepton sector. With a total exposure of 10 years to a neutrino beam produced by the 750 kW J-PARC proton synchrotron, it is expected that the CP phase δ can be determined to better than 18 degree for all possible values of δ if sin{sup 2} 2θ{sub 13} > 0.03 and the mass hierarchy is known. Control of systematic uncertainties is critical to make maximum use of the Hyper-K potential. Based on learning from T2K experience, a strategy to reduce systematic uncertainties in J-PARC/Hyper-K are developed.

  5. Hadronic Physics at J-PARC

    NASA Astrophysics Data System (ADS)

    Sawada, Shinya

    2009-10-01

    J-PARC, Japan Proton Accelerator Research Complex, has just finished its 1st phase construction, and got the 1st beams at the experimental facilities. Among the experimental facilities, such as the Materials and Life Science Experimental Facility and the Neutrino Experimental Facility, the Hadron Experimental Facility is for fixed target experiments which utilize the secondary beams produced by the proton beam slowly extracted from the 50-GeV synchrotron. At the Hadron Facility, the K1.8BR beam line, for secondary beams (pi, K, ...) up to 1.1 GeV/c, is already available, and the K1.8 beam line, for secondary beams up to 1.8 GeV/c, will be ready by the end of October, 2009. The neutral kaon beam line, KL, is also under construction and will be tested in this fall. Other beam lines, such as K1.1BR (for secondary beam up to 0.8 GeV/c), K1.1 (up to 1.1 GeV/c), and high-momentum beam line (low intensity primary protons and high momentum unseparated secondary beams), are in preparation. Among many experiments proposed so far (http://j-parc.jp/NuclPart/Proposal/e.html), some nuclear/hadron physics experiments as well as particle physics experiments are being conducted at these beam lines. In this talk, hadron physics experiments at the Hadron Experimental Facility of J-PARC are introduced with a review of their predecessors. In addition, a summary will be presented on the discussions related to J-PARC during the previous two days of the US-Japan seminar titled ``Meson Production Reactions at Jefferson Lab and J-PARC.''

  6. J-PARC status after the earthquake on March 11

    NASA Astrophysics Data System (ADS)

    Tanaka, Kazuhiro

    2012-09-01

    Recovery process of J-PARC from the disastrous influences of the Tohoku Regional Pacific Coast Earthquake is briefly summarized. Recovery itself is favorable for J-PARC and will be completed by the end of this year. We aim to perform 2-cycle (2 months) operation by the end of March (end of this Japanese Fiscal Year). Recent Activities of J-PARC on Particle and Nuclear Physics are also described.

  7. Un Exemple d'approche notionelle dans le cadre du francais fondamental (An Example of a Conceptual Approach within the Framework of "Le Francais fondamental")

    ERIC Educational Resources Information Center

    Combe-McBride, Nicole

    1977-01-01

    An inventory of grammatical and lexical units expressing the notion of place in "Le Francais fondamental," Level One. Interrelationships are discussed from the point of view of vocabulary patterns and syntax. There are numerous tables and examples of interrelated verbs, adverbs, nouns, and prepositions. (Text is in French.) (AMH)

  8. Neutrino Physics at J-PARC

    NASA Astrophysics Data System (ADS)

    Friend, Megan

    The physics motivation, status, and prospects of currently running and proposed neutrino experiments at J-PARC are shown. This includes the currently running T2K (Tokai-to-Kamioka) long-baseline neutrino oscillation experiment and a proposed Sterile Neutrino Search. The currently running T2K experiment detects oscillated ν μ to ν e appearance and unoscillated ν μ to ν μ disappearance neutrino events from an off-axis beam of primarily muon neutrinos produced at J-PARC. Propagated neutrinos are detected in a Near Detector complex, which sits 280 m from the neutrino source and is used to constrain the neutrino flux and measure neutrino cross sections, and in the Super-Kamiokande (SK) far detector, a 22.5 kT fiducial volume water Cherenkov detector with excellent performance in sub-GeV ν e/ν μ particle ID that sits 295 km from the neutrino source and is used to monitor neutrino oscillations. T2K has recently released a series of very interesting and important results, including the world's first definitive observation of neutrino appearance (ν e appearance from a ν μ beam), an observation which was made with only 8% of the proposed total data. T2K has continued to accumulate data since releasing these results, and has many exciting prospects, including potentially having sensitivity to show a first hint of CP violation in the lepton sector. These T2K recent results and future prospects will be shown. A brief overview of the prospects of a proposed future Sterile Neutrino Search, which plans to utilize the J-PARC Materials and Life Science Experimental Facility to initially search for sterile neutrinos with a large mass splitting, will also be shown.

  9. The TREK program at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK Collaboration

    2011-04-01

    The TREK program at J-PARC in Japan consists of a series of experiments that have been proposed to use the new, recently commissioned kaon beamline K1.1BR at the new J-PARC Hadron Facility. A beam of low-energy positively charged kaons will be stopped, and their decays observed with a large acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter and additional instrumentation with muon polarimeters. The first two experiments, requiring less beam intensity, aim to test lepton universality in the Ke 2 /Kμ 2 ratio with 0.2% statistical uncertainty, and to search for heavy sterile neutrinos in two-body kaon decays. Ultimately, the Time Reversal Experiment with Kaons (TREK) aims to find New Physics beyond the Standard Model by a precision measurement of the T-violating transverse polarization PT of muons in the Kμ3 + decay of stopped kaons with a sensitivity of 10-4. An overview of the planned experiments, results from recent R&D activities, and the current project status will be presented. Supported by DOE Early Career Award DE-SC0003884.

  10. La culture politique du Mouvement Quebec Francais [The Political Culture of the "French Quebec Movement"].

    ERIC Educational Resources Information Center

    Turcotte, Denis

    This study of the "Mouvement Quebec Francais (MQF)" covers the period from March 1971 through Spring 1974. The fundamental postulate of the study is that if the political culture is internalized by individuals, it is at the same time borne by groups. The study of groups represents, therefore, a good vehicle to reveal the most significant…

  11. "Le Francais Des Affaires": At the Crossroads of US/EU Trade and Language Policies.

    ERIC Educational Resources Information Center

    Finel-Honigman, Irene

    1997-01-01

    Discusses the need to enhance United States/European Union (EU) commercial and educational cooperation. Differences between US and EU language and trade policies are explored and the importance of plurilingualism in the global economy is examined. The role of the French Language, especially "Le francais des affaires," in facilitating access to the…

  12. Le "Francais Populaire" and French as a Second Language: A Comparative Study of Language Simplification.

    ERIC Educational Resources Information Center

    Kenemer, Virginia Lynn

    The French of English speaking students of French as a second language is compared with "francais populaire" (FP) in order to determine similarities in their tendency toward simplified grammar and morphology. Simplifying characteristics that are typical of FP were obtained from French working class sources, while simplification patterns of French…

  13. The Lycee Francais in New York: A Showcase for the French-Speaking Community

    ERIC Educational Resources Information Center

    Michel, Florence

    2004-01-01

    In New York they say that the architecture of the new "Lycee francais" (serving French students from kindergarten through upper secondary education) was inspired by the rationalism of Descartes. What is beyond doubt, however, is that the design and materials chosen by the American firm of architects, "Polshek Partnership Architects," which…

  14. Design concept for the microwave interrogation structure in PARCS

    NASA Technical Reports Server (NTRS)

    Dick, G. J.; Klipstein, W. M.; Heavner, T. P.; Jefferts, S. R.

    2002-01-01

    In this paper we will describe key aspects of the conceptual design of the microwave interrogation structure in the laser-cooled cesium frequency standard that is part of the Primary Atomic Reference Clock in Space (PARCS) experiment.

  15. Features Of The J-PARC Linac

    NASA Astrophysics Data System (ADS)

    Kobayashi, Tetsuya

    2011-06-01

    Japan Proton Accelerator Research Complex (J-PARC) will be one of the highest intensity proton accelerators in the world aiming to realize 1 MW class of the beam power. The accelerator consists of a 400-MeV linac, a 3-GeV rapid-cycling synchrotron (RCS) and a main ring synchrotron (MR), and the accelerated beam is applied to several experimental facilities. The linac, which is the injector for the RCS, has about 50 cavity modules to accelerate the beam up to 400 MeV. The acceleration field error in all of them should be within ±1% in amplitude and ±1 degree in phase because the momentum spread of the RCS injection beam is required to be within 0.1%. For the cavity field stabilization, a high-stable optical signal distribution system is used as the RF reference, and sophisticated digital feedback and feed-forward system is working well in the low level RF control system. Consequently the providing beam to the RCS is very stable, and the beam commissioning and the experiments of the application facilities have been progressed steadily.

  16. The TREK program at J-PARC

    NASA Astrophysics Data System (ADS)

    Djalali, Chaden; TREK Collaboration

    2012-02-01

    The TREK program consists of a series of experiments that have been proposed to use the new, recently commissioned kaon beamline K1.1BR at the new J-PARC Hadron Facility in Japan. A beam of low-energy positively charged kaons will be stopped, and their decays observed with a large acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter and additional instrumentation with muon polarimeters. The first two experiments, requiring less beam intensity, aim to test lepton universality in the Ke2/Kμ2 ratio with 0.2% statistical uncertainty, and to search for heavy sterile neutrinos in two-body kaon decays. Ultimately, the Time Reversal Experiment with Kaons (TREK) aims to find New Physics beyond the Standard Model by a precision measurement of the T-violating transverse polarization PT of muons in the K+μ3 decay of stopped kaons with a sensitivity of 10-4.

  17. Validation of a cross-section interface for PARCS

    SciTech Connect

    Staalek, M.; Demaziere, C.

    2006-07-01

    This paper deals with the validation of a cross-section interface for the PARCS code. Such an interface, of which the development is reported in [1], allows providing realistic sets of material constants to PARCS, so that the full dependence of these data on history variables, instantaneous variables, and exposure can be accounted for. In order to check the proper implementation of this interface, the PARCS code was benchmarked against actual plant data (relative power distribution throughout the core and criticality condition). For that purpose, the Swedish Ringhals-3 Pressurized Water Reactor was considered. Different fuel cycles and within each cycle different core exposures were investigated. The cross-section data for each fuel/reflector assembly constituting the considered cores were created accordingly. The spatial distributions of the instantaneous conditions, of the history effects, as well as of the burnup, were taken from the results of SIMULATE-3 calculations. It was found that PARCS was able to reproduce the relative distribution of the power within the core. Both the measured axial and radial power profiles were correctly calculated by PARCS. On the average, the deviation between the calculated and measured power distributions is within acceptable limits. Concerning the determination of the core criticality, the deviation of the effective multiplication factor from unity is typically within {+-}200 pcm. (authors)

  18. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1994.

    ERIC Educational Resources Information Center

    Mahler, M., Ed.; Haillet, P., Ed.

    1994-01-01

    Contains five articles, all in French, reporting research on French second language instruction. "Francophonie et francais langue seconde a l'oral: quel(s) culture(s), quelles methodes?" (Francophony and Spoken French as a Second Language: What Cultures(s), What Method(s) (D. Issa-Sayegh) discusses the content and structure of a university course…

  19. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1991-1993.

    ERIC Educational Resources Information Center

    Haillet, P., Ed.; And Others

    1993-01-01

    This document consists of the first two issues of the journal RELIEF. Each issue contains four articles. All articles deal with French second language instruction: (1) "Utiliser la presse ecrite en classe de francais-langue seconde (Using the Print Media in French Second Language Class)" (H. Canto); (2) "Une lecon de grammaire facile a concevoir,…

  20. Annual Report: 2014: Partners in Amphibian and Reptile Conservation (PARC)

    USGS Publications Warehouse

    Weir, Linda A.; Nanjappa, P.; Apodaca, J. J.; Williams, J.

    2015-01-01

    Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effects from overexploitation; these animals are also burdened by humans attitudes – that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural and cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation to ensure healthy populations of these animals has never been more important. As you will see herein, PARC’s 15th anniversary has been marked with major accomplishments and an ever-increasing momentum. With your help, PARC can continue to build on its successes and protect these vital species.

  1. High-energy hadron physics at J-PARC

    SciTech Connect

    Kumano, S.

    2008-10-13

    The J-PARC facility is near completion and experiments will start in 2009 on nuclear and particle physics projects. In this article, the J-PARC facility is introduced, and possible projects are discussed in high-energy hadron physics by using the primary proton beam of 30-50 GeV. There are proposed experiments on charm-production and Drell-Yan processes as well as single spin asymmetries for investigating quark and gluon structure of the nucleon and nuclei. Parton-energy loss could be studied in the Drell-Yan processes. There is also a proposal on hadron-mass modifications in a nuclear medium by using the proton beam. In addition, possible topics include transition from hadron to quark degrees of freedom by elastic pp scattering, color transparency by (p,2p), short-range correlation in nuclear force by (p,2pN), tensor structure functions for spin-one hadrons, fragmentation functions, and generalized partem distributions in the ERBL region although proposals are not written on these projects. If proton-beam polarization is attained, it is possible to investigate details of nucleon spin structure. In the last part of this article, our own studies are explained on partem distribution functions in connection with the J-PARC projects.

  2. TRACE/PARCS modelling of rips trip transients for Lungmen ABWR

    SciTech Connect

    Chang, C. Y.; Lin, H. T.; Wang, J. R.; Shih, C.

    2012-07-01

    The objectives of this study are to examine the performances of the steady-state results calculated by the Lungmen TRACE/PARCS model compared to SIMULATE-3 code, as well as to use the analytical results of the final safety analysis report (FSAR) to benchmark the Lungmen TRACE/PARCS model. In this study, three power generation methods in TRACE were utilized to analyze the three reactor internal pumps (RIPs) trip transient for the purpose of validating the TRACE/PARCS model. In general, the comparisons show that the transient responses of key system parameters agree well with the FSAR results, including core power, core inlet flow, reactivity, etc. Further studies will be performed in the future using Lungmen TRACE/PARCS model. After the commercial operation of Lungmen nuclear power plant, TRACE/PARCS model will be verified. (authors)

  3. Performance of the PARCS Testbed Cesium Fountain Frequency Standard

    NASA Technical Reports Server (NTRS)

    Enzer, Daphna G.; Klipstein, William M.

    2004-01-01

    A cesium fountain frequency standard has been developed as a ground testbed for the PARCS (Primary Atomic Reference Clock in Space) experiment, an experiment intended to fly on the International Space Station. We report on the performance of the fountain and describe some of the implementations motivated in large part by flight considerations, but of relevance for ground fountains. In particular, we report on a new technique for delivering cooling and trapping laser beams to the atom collection region, in which a given beam is recirculated three times effectively providing much more optical power than traditional configurations. Allan deviations down to 10 have been achieved with this method.

  4. Overview of Hadron Physics at J-PARC

    NASA Astrophysics Data System (ADS)

    Tanida, Kiyoshi

    In this article, a brief overview of Hadron Hall facility of J-PARC is given, and some of the experimental results on hadron physics are shown. Especially interesting results are obtained in E27 experiment where a peak position in the d(π + ,K + ) missing mass spectrum suggests a significant mass shift of Σ(1385) and/or Λ(1405). Results for penta-quark search in p(π - ,K + ) reaction (E19) are also reported. Then, finally, a (near) future experiment related to nucleon and hyperon spectroscopy is introduced.

  5. Precision measurement of muonium hyperfine splitting at J-PARC

    NASA Astrophysics Data System (ADS)

    Kanda, Sohtaro; J-PARC MuHFS Collaboration

    2014-09-01

    Muonium is the bound state of a positive muon and an electron. Because neither muon nor electron has internal structure, muonium's ground state hyperfine splitting (MuHFS) can be the most precise probe for the test of the bound state QED and for the determination of the ratio of magnetic moments of muon and proton. At J-PARC, we plan to perform a precision measurement of the MuHFS via microwave spectroscopy of muonium. Muonium is formed in Kr gas target and state transition between energy levels is induced by microwave resonance. Spectroscopy of the muonium states can be performed by measurement of positron asymmetry from muonium decay. Precision of the most recent experimental result (LAMPF1999) was mostly statistically limited. Hence, improved statistics is essential for higher precision of the measurement. Our goal is to improve accuracy by an order of magnitude compared to the most recent experiment. In order to achieve the goal, we utilize J-PARC's highest-intensity pulsed muon beam (expected intensity is 1 ×108μ+ / s), highly segmented positron detector with SiPM (Silicon PhotoMultiplier), and an online/offline muon beam profile monitor. In this presentation, we discuss the experimental overview and development status of each components.

  6. Proposal to Participate in J-Parc KL Experiment

    SciTech Connect

    Campbell, Myron; Tecchio, Monica

    2013-02-03

    During the previous grant period we have been working on the J-PARC KL E14 (KOTO) experiment with the goal to discover and measure the rate of the rare decay neutral kaons to a pion and two neutrinos. This CP-violating flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement to the branching ratio, which in the Standard Model predicted to be about 2.80E-11. The experiment is expected to observe 100 events at the Standard Model branching ratio for a 10% measurement. The experiment is a follow-up to E391a at KEK and has been approved as experiment E14 at J-PARC. The main barrel vacuum vessel, the charged veto detectors, and the main barrel photon veto system will be reused from E391a. The main calorimeter has been replaced with Cesium Iodide crystals that are both smaller to provide improved shower reconstruction and longer to prevent energy leakage out of the back of the calorimeter. New trigger and data acquisitions electronics will be used.

  7. Precision spectroscopy of kaonic {sup 3}He X-rays at J-PARC

    SciTech Connect

    Sato, M.; Fujiwara, Y.; Hashimoto, T.; Hayano, R. S.; Ishikawa, T.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Wuenschek, B.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.; Vidal, A. Romero

    2011-10-24

    We will measure the X-rays from kaonic {sup 3}He 3d {yields} 2p transition with a precision below 2 eV. It can provide crucial information on the kaon-nucleus strong interaction. The experiment (J-PARC E17) will be performed as Day-1, which is one of the first experiments in the J-PARC hadron facility in the year 2011. An overview and the present status of the J-PARC E17 experiment are described.

  8. The E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael

    2013-04-01

    The E36 experiment is planned to run at the J-PARC K1.1BR kaon beamline in 2014-15 using a stopped kaon beam along with the TREK target and detector setup. The decay products of stopped positive kaons will be observed with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke2/Kμ2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for a heavy sterile neutrino in two-body kaon decay, along with additional searches for exotic decay modes. An overview of the planned experiment, results from recent R&D activities, and the current project status will be presented.

  9. The TREK/E36 experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, M.; TREK Collaboration

    2013-11-01

    Experiment E36 is planned to run at the J-PARC K1.1BR kaon beamline in 2014-15 using a stopped kaon beam along with the TREK target and detector setup. The decay products of stopped positive kaons will be observed with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke2/Kμ2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for a heavy sterile neutrino in two-body kaon decay, along with additional searches for exotic decay modes including the possibility to produce a dark photon and to observe its decay into an e+e- pair. An overview of the planned measurements with E36 will be presented.

  10. Calculation of Accurate Hexagonal Discontinuity Factors for PARCS

    SciTech Connect

    Pounders. J., Bandini, B. R. , Xu, Y, and Downar, T. J.

    2007-11-01

    In this study we derive a methodology for calculating discontinuity factors consistent with the Triangle-based Polynomial Expansion Nodal (TPEN) method implemented in PARCS for hexagonal reactor geometries. The accuracy of coarse-mesh nodal methods is greatly enhanced by permitting flux discontinuities at node boundaries, but the practice of calculating discontinuity factors from infinite-medium (zero-current) single bundle calculations may not be sufficiently accurate for more challenging problems in which there is a large amount of internodal neutron streaming. The authors therefore derive a TPEN-based method for calculating discontinuity factors that are exact with respect to generalized equivalence theory. The method is validated by reproducing the reference solution for a small hexagonal core.

  11. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide

    SciTech Connect

    Vitali, Roberta; Cesi, Vincenzo; Tanno, Barbara; Ferrari-Amorotti, Giovanna; Dominici, Carlo; Calabretta, Bruno; Raschella, Giuseppe

    2008-04-04

    We tested the activity of a p53 carboxy-terminal peptide containing the PARC-interacting region in cancer cells with wild type cytoplasmic p53. Peptide delivery was achieved by fusing it to the TAT transduction domain (TAT-p53-C-ter peptide). In a two-hybrid assay, the tetramerization domain (TD) of p53 was necessary and sufficient to bind PARC. The TAT-p53-C-ter peptide disrupted the PARC-p53 complex. Peptide treatment caused p53 nuclear relocation, p53-dependent changes in gene expression and enhancement of etoposide-induced apoptosis. These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.

  12. Mechanism of DNA Segregation in Prokaryotes: Replicon Pairing by parC of Plasmid R1

    NASA Astrophysics Data System (ADS)

    Jensen, Rasmus Bugge; Lurz, Rudi; Gerdes, Kenn

    1998-07-01

    Prokaryotic chromosomes and plasmids encode partitioning systems that are required for DNA segregation at cell division. The systems are thought to be functionally analogous to eukaryotic centromeres and to play a general role in DNA segregation. The parA system of plasmid R1 encodes two proteins ParM and ParR, and a cis-acting centromere-like site denoted parC. The ParR protein binds to parC in vivo and in vitro. The ParM protein is an ATPase that interacts with ParR specifically bound to parC. Using electron microscopy, we show here that parC mediates efficient pairing of plasmid molecules. The pairing requires binding of ParR to parC and is stimulated by the ParM ATPase. The ParM mediated stimulation of plasmid pairing is dependent on ATP hydrolysis by ParM. Using a ligation kinetics assay, we find that ParR stimulates ligation of parC-containing DNA fragments. The rate-of-ligation was increased by wild type ParM protein but not by mutant ParM protein deficient in the ATPase activity. Thus, two independent assays show that parC mediates pairing of plasmid molecules in vitro. These results are consistent with the proposal that replicon pairing is part of the mechanism of DNA segregation in prokaryotes.

  13. A Design for Living: The PARC Plan. Report of the PARC Ad Hoc Planning Committee for Resolution II, October 19, 1974.

    ERIC Educational Resources Information Center

    Pennsylvania Association for Retarded Citizens, Harrisburg.

    Presented is the PARC (Pennsylvania Association for Retarded Citizens) Plan which resulted from a 3-month survey of Pennsylvania's institutional system and which was designed to improve living conditions and programs of state schools and hospitals serving the mentally retarded. Detailed are specific recommendations for the achievement of annual…

  14. Ultra Slow Muon Project at J-PARC, MUSE

    SciTech Connect

    Miyake, Y.; Nakahara, K.; Shimomura, K.; Strasser, P.; Kawamura, N.; Koda, A.; Makimura, S.; Fujimori, H.; Nishiyama, K.; Matsuda, Y.; Bakule, P.; Adachi, T.; Ogitsu, T.

    2009-03-17

    The muon science facility (MUSE), along with the neutron, hadron, and neutrino facilities, is one of the experimental areas of the J-PARC project, which was approved for construction at the Tokai JAEA site. The MUSE facility is located in the Materials and Life Science Facility (MLF), which is a building integrated to include both neutron and muon science programs. Construction of the MLF building was started in the beginning of 2004, and first muon beam is expected in the autumn of 2008.As a next step, we are planning to install, a Super Omega muon channel with a large acceptance of 400 msr, to extract the world strongest pulsed surface muon beam. Its goal is to extract 4x10{sup 8} surface muons/s for the generation of the intense ultra slow muons, utilizing laser resonant ionization of Mu by applying an intense pulsed VUV laser system. As maximum 1x10{sup 6} ultra slow muons/s will be expected, which will allow for the extension of {mu}SR into the field of thin film and surface science.

  15. D'une ouverture de la voyelle /epsilon/ en finale absolue en francais quebecois : analyse acoustique et perceptive

    NASA Astrophysics Data System (ADS)

    Riverin-Coutlee, Josiane

    Cette contribution est consacree a l'ouverture du /epsilon/ en finale absolue, un phenomene phonetique repute etre en declin en francais quebecois et caracteristique de locuteurs âges, peu scolarises, issus de milieux populaires et s'exprimant en situation de communication informelle. Une analyse acoustique de 480 voyelles /epsilon/ issues de la parole formelle de 40 jeunes etudiants universitaires originaires des centres urbains de Saguenay et de Quebec revele toutefois que le phenomene est encore bien vivant en francais quebecois et qu'il est plus frequent chez les locuteurs de Saguenay, une tendance validee auditivement par accord inter-juges. Les resultats d'un test de discrimination et d'identification mene aupres de 26 etudiants universitaires originaires de ces deux memes villes indiquent que les auditeurs naifs de Saguenay semblent moins sensibles a la variation et moins enclins a juger de l'origine geographique d'un locuteur a partir de sa prononciation de la voyelle /epsilon/ en fin de mot.

  16. PARC Navier-Stokes code upgrade and validation for high speed aeroheating predictions

    NASA Technical Reports Server (NTRS)

    Liver, Peter A.; Praharaj, Sarat C.; Seaford, C. Mark

    1990-01-01

    Applications of the PARC full Navier-Stokes code for hypersonic flowfield and aeroheating predictions around blunt bodies such as the Aeroassist Flight Experiment (AFE) and Aeroassisted Orbital Transfer Vehicle (AOTV) are evaluated. Two-dimensional/axisymmetric and three-dimensional perfect gas versions of the code were upgraded and tested against benchmark wind tunnel cases of hemisphere-cylinder, three-dimensional AFE forebody, and axisymmetric AFE and AOTV aerobrake/wake flowfields. PARC calculations are in good agreement with experimental data and results of similar computer codes. Difficulties encountered in flowfield and heat transfer predictions due to effects of grid density, boundary conditions such as singular stagnation line axis and artificial dissipation terms are presented together with subsequent improvements made to the code. The experience gained with the perfect gas code is being currently utilized in applications of an equilibrium air real gas PARC version developed at REMTECH.

  17. Science Goals of the Primary Atomic Reference Clock in Space (PARCS) Experiment

    NASA Technical Reports Server (NTRS)

    Ashby, N.

    2003-01-01

    The PARCS (Primary Atomic Reference Clock in Space) experiment will use a laser-cooled Cesium atomic clock operating in the microgravity environment aboard the International Space Station (ISS) to provide both advanced tests of gravitational theory and to demonstrate a new cold-atom clock technology for space. PARCS is a joint project of the National Institute of Standards and Technology (NIST), NASA's Jet Propulsion Laboratory (JPL), and the University of Colorado (CU). This paper concentrates on the scientific goals of the PARCS mission. The microgravity space environment allows laser-cooled Cs atoms to have Ramsey times in excess of those feasible on Earth, resulting in improved clock performance. Clock stabilities of 5x10(exp -14) at one second, and accuracies better than 10(exp -16) are projected.

  18. Cryogenic system for COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Ki, Taekyung; Yoshida, Makoto; Yang, Ye; Ogitsu, Toru; Iio, Masami; Makida, Yasuhiro; Okamura, Takahiro; Mihara, Satoshi; Nakamoto, Tatsushi; Sugano, Michinaka; Sasaki, Ken-ichi

    2016-07-01

    Superconducting conductors and cryogenic refrigeration are key factors in the accelerator science because they enable the production of magnets needed to control and detect the particles under study. In Japan, a system for COMET (Coherent Muon to Electron Transition), which will produce muon beam lines, is under the construction at J-PARC (Japan Proton Accelerator Research Complex). The system consists of three superconducting magnets; the first is a pion-capture solenoid, the second is a muon-transport solenoid, and the third is a detector solenoid. It is necessary to cool down the magnets efficiently using two-phase helium and maintain them securely at 4.5 K. For stable cryogenic refrigeration of the magnets, a suitable cooling method, structures, and the irradiation effect on materials should be investigated. In this paper, we focus on the development of an overall cryogenic system for cooling the capture and transport solenoids. A conduction-cooling method is considered for cooling the capture and transport solenoids because of the advantages such as the reduction of total heat load, fewer components, and simplified structure. To supply cryogenic fluids (4.5 K liquid helium and 58 K gas helium) and currents to the conduction-cooled magnets subjected to high irradiation, cryogenic components (cooling paths in the magnets, transfer tubes, and a current lead box) are developed. Based on the environment of high irradiation, the conditions (temperature and pressure) of helium in cooling paths are estimated, as well as the temperature of the capture magnet. We develop a dynamic model for quench simulation and estimate the maximum pressure in the cooling pipe when the capture magnet quenches. We conclude with a discussion of the next steps and estimated challenges for the cryogenic system.

  19. Status and Prospects of the Muonium Experiment at J-Parc

    NASA Astrophysics Data System (ADS)

    Torii, H. A.; Tanaka, K. S.; Tajima, M.; Mizutani, T.; Matsuda, Y.; Fukao, Y.; Iinuma, H.; Ikedo, Y.; Kadono, R.; Kawamura, N.; Koda, A.; Kojima, K.; Mibe, T.; Miyake, Y.; Nagamine, K.; Nishiyama, K.; Ohkubo, R.; Ogitsu, T.; Saito, N.; Sasaki, K.; Shimomura, K.; Strasser, P.; Sugano, M.; Toyoda, A.; Ueno, K.; Yamamoto, A.; Yoshida, M.; Ishida, K.; Iwasaki, M.; Kamigaito, O.; Kanda, S.; Tomono, D.; Ueno, Y.; Kubo, K.; Aoki, M.; Torikai, E.; Kawall, D.

    2014-12-01

    A microwave spectroscopy experiment of muonium atoms are being prepared at J-PARC in Japan, aiming at an improved relative precision at a level of 10-8 in determination of the muonic magnetic moment. A major improvement of statistical uncertainty is due to higher muon intensity of the pulsed beam at J-PARC, while further improvements are expected for systematic uncertainties. Reduction of sources of systematic uncertainties are being studied: those arising from microwave power fluctuations, magnetic field inhomogeneity, muon stopping distribution and gas-density shift of resonance frequencies. Status and prospects of studies and developments of the experiment is presented in this paper.

  20. Measurement of neutron capture cross section of Li-7 at J-PARC / MLF / ANNRI

    SciTech Connect

    Makii, H.; Ota, S.; Nishinaka, I.; Nishio, I.; Segawa, M.; Kimura, A.; Harada, H.

    2014-05-02

    We have measured the {sup 7}Li(n,γ){sup 8}Li reaction at Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) installed at the Material and Life science experimental Facility in the Japan Proton Accelerator Research Complex (J-PARC / MLF). In this experiment, we used intense pulsed neutron beam provided by J-PARC / MLF and high performance Ge spectrometer, which is one of the main detectors of the ANNRI. We clearly detected γ rays from the {sup 7}Li(n,γ){sup 8}Li reaction with sufficient signal-to-noise ratio.

  1. Precision Spectroscopy of Kaonic Helium-3 X-rays at J-PARC

    SciTech Connect

    Hashimoto, T.; Fujiwara, Y.; Hayano, R. S.; Ishikawa, T.; Sato, M.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Widmann, E.; Wuenschek, B. K.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.

    2011-10-21

    We will measure the x-rays from kaonic {sup 3}He and {sup 4}He 3d{yields}2p transition by using silicon drift detectors. Our precision goal is set to 1 eV to provide crucial information on the kaon-nucleus strong interaction in the low energy limit. The experiment is to be performed as one of the first experiment in the J-PARC hadron facility (J-PARC E17). An overview and the present status of the experiment are presented.

  2. L'enseignement modulaire et le laboratoire de langues: conception et experimentation d'un nouveau cours de francais oral au Centre d'anglais et de francais, Universite McGill (Modular Instruction and the Language Laboratory: Conception and Experimentation with a New Course in Oral French at the English and French Center, McGill University).

    ERIC Educational Resources Information Center

    Legoux, Marie-Noelle

    1980-01-01

    A modular-type course in French was developed at the "Centre d'anglais et de francais" at McGill University (Montreal) to meet the needs of incoming students who were lacking skills in listening and oral expression. The course is composed of eight modules a semester, each module corresponding to 15 to 20 hours work on the student's part. The…

  3. L'enseignement du francais en Republique Federale d'Allemagne (The Teaching of French in the Federal Republic of Germany). L'enseignement du francais dans les classes terminales des lycees allemands (The Teaching of French in the Final Year in German Schools).

    ERIC Educational Resources Information Center

    Abel, Fritz; Lang, Jurgen

    Two papers describe two aspects of French foreign language instruction in West Germany. The first, "L'enseignement du francais en Republique Federale d'Allemagne" by Abel, deals with the institutional framework for French instruction in West Germany. A discussion of the instructional situation looks first at the history of French instruction since…

  4. TRACE/PARCS Core Modeling of a BWR/5 for Accident Analysis of ATWS Events

    SciTech Connect

    Cuadra A.; Baek J.; Cheng, L.; Aronson, A.; Diamond, D.; Yarsky, P.

    2013-11-10

    The TRACE/PARCS computational package [1, 2] isdesigned to be applicable to the analysis of light water reactor operational transients and accidents where the coupling between the neutron kinetics (PARCS) and the thermal-hydraulics and thermal-mechanics (TRACE) is important. TRACE/PARCS has been assessed for itsapplicability to anticipated transients without scram(ATWS) [3]. The challenge, addressed in this study, is to develop a sufficiently rigorous input model that would be acceptable for use in ATWS analysis. Two types of ATWS events were of interest, a turbine trip and a closure of main steam isolation valves (MSIVs). In the first type, initiated by turbine trip, the concern is that the core will become unstable and large power oscillations will occur. In the second type,initiated by MSIV closure,, the concern is the amount of energy being placed into containment and the resulting emergency depressurization. Two separate TRACE/PARCS models of a BWR/5 were developed to analyze these ATWS events at MELLLA+ (maximum extended load line limit plus)operating conditions. One model [4] was used for analysis of ATWS events leading to instability (ATWS-I);the other [5] for ATWS events leading to emergency depressurization (ATWS-ED). Both models included a large portion of the nuclear steam supply system and controls, and a detailed core model, presented henceforth.

  5. Study on Λ6H hypernucleus by the (π-, K+) reaction at J-PARC

    NASA Astrophysics Data System (ADS)

    Sugimura, H.; Agnello, M.; Ahn, J. K.; Ajimura, S.; Akazawa, Y.; Amano, N.; Aoki, K.; Bhang, H. C.; Endo, M.; Evtoukhovitch, P.; Feliciello, A.; Fujioka, H.; Fukuda, T.; Hasegawa, S.; Hayakawa, S.; Honda, R.; Hosomi, K.; Hwang, S. H.; Ichikawa, Y.; Igarashi, Y.; Imai, K.; Ishibashi, N.; Iwasaki, R.; Joo, C. W.; Kiuchi, R.; Lee, J. K.; Lee, J. Y.; Matsuda, K.; Matsumoto, Y.; Matsuoka, K.; Miwa, K.; Mizoi, Y.; Moritsu, M.; Nagae, T.; Nagamiya, S.; Nakagawa, M.; Naruki, M.; Noumi, H.; Ota, R.; Roy, B. J.; Saha, P. K.; Sakaguchi, A.; Sako, H.; Samanta, C.; Samoilov, V.; Sasaki, Y.; Sato, S.; Sekimoto, M.; Shimizu, Y.; Shiozaki, T.; Shirotori, K.; Soyama, T.; Takahashi, T.; Takahashi, T. N.; Tamura, H.; Tanabe, K.; Tanaka, T.; Tanida, K.; Tokiyasu, A. O.; Tsamalaidze, Z.; Ukai, M.; Yamamoto, T. O.; Yamamoto, Y.; Yang, S. B.; Yoshida, K.

    2014-03-01

    We carried out an experiment to produce the neutron-rich hypernucleus Λ6H via the (π-, K+) reaction on 6Li target at the pion beam momentum of 1.2 GeV/c (J-PARC E10). In order to calibrate the scale of the missing-mass or of the Λ binding energy of the hypernucleus, we also measured the 12C(π+, K+) Λ12C, p(π-, K+)Σ- and p(π+, K+)Σ+reactions. The experiment was performed at the J-PARC Hadron Hall K1.8 beam line in December 2012 and January 2013. The overall collected data sample corresponds to an integrated beam intensity of 1.65 × 1012 pions.

  6. Fine-tuning to minimize emittances of J-PARC RF-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Ueno, A.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Oguri, H.

    2016-02-01

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H- ion source has been successfully operated for about one year. By the world's brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. In order to minimize the transverse emittances, the rod-filter-field (RFF) was optimized by changing the triple-gap-lengths of each of pairing five piece rod-filter-magnets. The larger emittance degradation seems to be caused by impurity-gases than the RFF. The smaller beam-hole-diameter of the extraction electrode caused the more than expected improvements on not only the emittances but also the peak beam intensity.

  7. Neutron capture cross section measurements at the beam line 04 of J-PARC/MLF

    SciTech Connect

    Igashira, Masayuki; Harada, Hideo; Kiyanagi, Yoshiaki

    2012-11-12

    An Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI) at the beam line 04 of MLF (Material and Life Sciences Experimental Facilities) of J-PARC (Japan Proton Accelerator Research Complex) was installed to measure neutron capture cross sections related to the research and development of innovative nuclear systems, the study on nuclear astrophysics, etc. ANNRI has two gamma-ray spectrometers: one is a Ge detector array placed at 22 m from the coupled type moderator of the spallation neutron source of J-PARC/MLF and the other is a pair of NaI(Tl) detectors at 28 m. Until the 11th of March, 2011, when we had big earthquakes, we measured capture cross sections of Zr-93, Tc-99, Pd-107, I-129, Cm-244, Cm-246, etc. After checking and repairing ANNRI, we restarted measurements, and ANNRI has been open to worldwide users at present.

  8. Code Development in Coupled PARCS/RELAP5 for Supercritical Water Reactor

    DOE PAGES

    Hu, Po; Wilson, Paul

    2014-01-01

    The new capability is added to the existing coupled code package PARCS/RELAP5, in order to analyze SCWR design under supercritical pressure with the separated water coolant and moderator channels. This expansion is carried out on both codes. In PARCS, modification is focused on extending the water property tables to supercritical pressure, modifying the variable mapping input file and related code module for processing thermal-hydraulic information from separated coolant/moderator channels, and modifying neutronics feedback module to deal with the separated coolant/moderator channels. In RELAP5, modification is focused on incorporating more accurate water properties near SCWR operation/transient pressure and temperature in themore » code. Confirming tests of the modifications is presented and the major analyzing results from the extended codes package are summarized.« less

  9. A novel precision measurement of muon g - 2 and EDM at J-PARC

    SciTech Connect

    Saito, Naohito; Collaboration: J-PARC g-2 /EDM Collaboration

    2012-07-27

    We propose a new experiment to measure the muon anomalous magnetic moment g - 2 and electric dipole moment with a novel technique called ultra-slow muon beam at J-PARC. Precision measurement of these dipole moments plays an important role in fundamental physics to search for a new physics beynd standard model. The concept of the experiment and its current status is described.

  10. Development of GEM trigger electronics for the J-PARC E16 experiment

    NASA Astrophysics Data System (ADS)

    Obara, Y.; Hamada, E.; Ikeno, M.; Kawama, D.; Morino, Y.; Nakai, W.; Ozawa, K.; Sendai, H.; Takahashi, T. N.; Tanaka, M. M.; Uchida, T.; Yokkaichi, S.

    2015-12-01

    At the J-PARC E16 experiment[1], we measure mass spectra of vector mesons in nuclei from the e+e- decay channel with high precision and high statistics. We have developed the trigger system consisting of newly developed ASD ASICs which can extract signals from the GEM foil used as a cathode plane of the induction gap in a GEM chamber and digital electronics using FPGAs which processes binary signals from the ASIC.

  11. Operation and development status of the J-PARC ion source

    SciTech Connect

    Yamazaki, S. Ikegami, K.; Ohkoshi, K.; Ueno, A.; Koizumi, I.; Takagi, A.; Oguri, H.

    2014-02-15

    A cesium-free H{sup −} ion source driven with a LaB{sub 6} filament is being operated at the Japan Proton Accelerator Research Complex (J-PARC) without any serious trouble since the restoration from the March 2011 earthquake. The H{sup −} ion current from the ion source is routinely restricted approximately 19 mA for the lifetime of the filament. In order to increase the beam power at the linac beam operation (January to February 2013), the beam current from the ion source was increased to 22 mA. At this operation, the lifetime of the filament was estimated by the reduction in the filament current. According to the steep reduction in the filament current, the break of the filament was predicted. Although the filament has broken after approximately 10 h from the steep current reduction, the beam operation was restarted approximately 8 h later by the preparation for the exchange of new filament. At the study time for the 3 GeV rapid cycling synchrotron (April 2013), the ion source was operated at approximately 30 mA for 8 days. As a part of the beam current upgrade plan for the J-PARC, the front end test stand consisting of the ion source and the radio frequency quadrupole is under preparation. The RF-driven H{sup −} ion source developed for the J-PARC 2nd stage requirements will be tested at this test stand.

  12. [Chiral Transformation of PARC18 Assemblies on NaOH Solution Subphase].

    PubMed

    Wang, Xiao-yu; Li, Lin; Lin, Lu; Zhang, Zhen; Lu, Zhou; Liu, Ming-hua; Gug, Yuan

    2016-01-01

    Achiral molecules with conjugated structures can form chiral supramolecules through interfacial self-assembly. These spontaneous symmetry breaking processes may help elucidate the origin of life and are thus of great importance. So far, the mechanism of interfaciam self-assembly has been discussed in detail. However, dynamics of the chiral assemblies was rarely investigated. In order to clarify whether the chiral structures are stable or dynamic, we employed second harmonic generation linear dichroism (SHG-LD) to investigate the supramolecular chirality of PARC18 at air/aqueous interface. It was shown that PARC18 formed chiral structures with stable chiral state at air/water interface. While at air/NaOH solution interface, the chiral state changed with time. In addition, on NaOH solution subphase, contributions of magnetic dipole to second harmonic signals were dominant. We suggest that this is due to isomerization of PARC18 molecules on NaOH solution subphase. As a result, the two chromophores coupled with each other and the magnetic dipole contribution was enhanced.

  13. Operation Status of the J-PARC Negative Hydrogen Ion Source

    SciTech Connect

    Oguri, H.; Ikegami, K.; Ohkoshi, K.; Namekawa, Y.; Ueno, A.

    2011-09-26

    A cesium-free negative hydrogen ion source driven with a lanthanum hexaboride (LaB{sub 6}) filament is being operated without any serious trouble for approximately four years in J-PARC. Although the ion source is capable of producing an H{sup -} ion current of more than 30 mA, the current is routinely restricted to approximately 16 mA at present for the stable operation of the RFQ linac which has serious discharge problem from September 2008. The beam run is performed during 1 month cycle, which consisted of a 4-5 weeks beam operation and a few days down-period interval. At the recent beam run, approximately 700 h continuous operation was achieved. At every runs, the beam interruption time due to the ion source failure is a few hours, which correspond to the ion source availability of more than 99%. The R and D work is being performed in parallel with the operation in order to enhance the further beam current. As a result, the H{sup -} ion current of 61 mA with normalized rms emittance of 0.26 {pi}mm.mrad was obtained by adding a cesium seeding system to a J-PARC test ion source which has the almost same structure with the present J-PARC ion source.

  14. Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly1[OPEN

    PubMed Central

    Chen, Cheng; Froehlich, John E.; TerBush, Allan D.

    2016-01-01

    Chloroplast division is driven by the simultaneous constriction of the inner FtsZ ring (Z ring) and the outer DRP5B ring. The assembly and constriction of these rings in Arabidopsis (Arabidopsis thaliana) are coordinated partly through the inner envelope membrane protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS6 (ARC6). Previously, we showed that PARC6 (PARALOG OF ARC6), also in the inner envelope membrane, negatively regulates FtsZ assembly and acts downstream of ARC6 to position the outer envelope membrane protein PLASTID DIVISION1 (PDV1), which functions together with its paralog PDV2 to recruit DYNAMIN-RELATED PROTEIN 5B (DRP5B) from a cytosolic pool to the outer envelope membrane. However, whether PARC6, like ARC6, also functions in coordination of the chloroplast division contractile complexes was unknown. Here, we report a detailed topological analysis of Arabidopsis PARC6, which shows that PARC6 has a single transmembrane domain and a topology resembling that of ARC6. The newly identified stromal region of PARC6 interacts not only with ARC3, a direct inhibitor of Z-ring assembly, but also with the Z-ring protein FtsZ2. Overexpression of PARC6 inhibits FtsZ assembly in Arabidopsis but not in a heterologous yeast system (Schizosaccharomyces pombe), suggesting that the negative regulation of FtsZ assembly by PARC6 is a consequence of its interaction with ARC3. A conserved carboxyl-terminal peptide in FtsZ2 mediates FtsZ2 interaction with both PARC6 and ARC6. Consistent with its role in the positioning of PDV1, the intermembrane space regions of PARC6 and PDV1 interact. These findings provide new insights into the functions of PARC6 and suggest that PARC6 coordinates the inner Z ring and outer DRP5B ring through interaction with FtsZ2 and PDV1 during chloroplast division. PMID:26527658

  15. Development of a Muon Rotating Target for J-PARC/MUSE

    NASA Astrophysics Data System (ADS)

    Makimura, Shunsuke; Kobayashi, Yasuo; Miyake, Yasuhiro; Kawamura, Naritoshi; Strasser, Patrick; Koda, Akihiro; Shimomura, Koichiro; Fujimori, Hiroshi; Nishiyama, Kusuo; Kato, Mineo; Kojima, Kenji; Higemoto, Wataru; Ito, Takashi; Shimizu, Ryou; Kadono, Ryosuke

    At the J-PARC muon science facility (J-PARC/MUSE), a graphite target with a thickness of 20 mm has been used in vacuum to obtain an intense pulsed muon beam from the RCS 3-GeV proton beam [1], [2]. In the current design, the target frame is constructed using copper with a stainless steel tube embedded for water cooling. The energy deposited by the proton beam at 1 MW is evaluated to be 3.3 kW on the graphite target and 600 W on the copper frame by a Monte-Carlo simulation code, PHITS [3]. Graphite materials are known to lose their crystal structure and can be shrunk under intense proton beam irradiation. Consequently, the lifetime of the muon target is essentially determined by the radiation damage in graphite, and is evaluated to be half a year [4]. Hence, we are planning to distribute the radiation damage by rotating a graphite wheel. Although the lifetime of graphite in this case will be more than 10 years, the design of the bearing must be carefully considered. Because the bearing in JPARC/MUSE is utilized in vacuum, under high radiation, and at high temperature, an inorganic and solid lubricant must be applied to the bearing. Simultaneously, the temperature of the bearing must also be decreased to extend the lifetime. In 2009, a mock-up of the Muon Rotating Target, which could heat up and rotate a graphite wheel, was fabricated. Then several tests were started to select the lubricant and to determine the structure of the Muon Rotating Target, the control system and so on. In this report, the present status of the Muon Rotating Target for J-PARC/MUSE, especially the development of a rotation system in vacuum, is described.

  16. Linear Coupling Resonance Correction of the J-PARC Main Ring

    NASA Astrophysics Data System (ADS)

    Takano, Junpei; Igarashi, Susumu; Molodozhentsev, Alexander; Someya, Hirohiko

    We have constructed skew quadrupole magnets (SQ) for the correction of linear coupling resonances (LCR) at the main ring (MR) of the Japan Proton Accelerator Research Complex (J-PARC). The LCR at Qx + Qy = 43 will cause a significant beam loss at the design beam power of 750 kW. In order to correct the LCR, parameters of the SQs are searched through beam based studies with low intensity by setting the MR operating tune at the LCR. The LCR was successfully corrected and a significant improvement of the beam survival ratio was achieved. A detail design specification and field measurements of the SQs including beam study results are presented.

  17. A Phase Space Monitoring of Injected Beam of J-PARC MR

    NASA Astrophysics Data System (ADS)

    Hatakeyama, Shuichiro; Toyama, Takeshi

    Beam power of J-PARC MR (30 GeV Proton Synchrotron Main Ring) has been improved since 2008 and now achieved over 200 kW for the user operation. A part of beam loss is localized at the beam injection phase so it is important to monitor the beam bunch behavior in the transverse direction. In this paper it is described the method how to measure the position and momentum for each injected beam bunch using Beam Position Monitors (BPMs). It is also mentioned some implementation of an operator's interface (OPI) to display the plots of injected and circulating beam bunches in phase space coordinate.

  18. Quantum-gravity decoherence effects in neutrino oscillations: Expected constraints from CNGS and J-PARC

    SciTech Connect

    Mavromatos, Nick E.; Sarkar, Sarben; Meregaglia, Anselmo; Sakharov, Alexander S.

    2008-03-01

    Quantum decoherence, the evolution of pure states into mixed states, may be a feature of quantum-gravity models. In most cases, such models lead to fewer neutrinos of all active flavors being detected in a long-baseline experiment as compared to three-flavor standard neutrino oscillations. We discuss the potential of the CNGS and J-PARC beams in constraining models of quantum-gravity induced decoherence using neutrino oscillations as a probe. We use as much as possible model-independent parametrizations, even though they are motivated by specific microscopic models, for fits to the expected experimental data which yield bounds on quantum-gravity decoherence parameters.

  19. Hadron Physics at J-PARC —Exotic Hadrons and Hadrons in Nuclei—

    NASA Astrophysics Data System (ADS)

    Jido, Daisuke

    A personal view of hadron physics being developed at J-PARC is presented in this article. Hadrons are particles interacting each other with the strong interaction, being composed of quarks and gluons, of which dynamics governs quantum chromodynamics (QCD). Although the fundamental theory of the strong interaction is written beautifully in a simple way, its dynamical consequence is very complicated and makes hadron physics rich. In this paper, I select two topics, exotic hadrons which are not explained by conventional quark models and hadron in nucleus which will be a tool to investigate the vacuum property of QCD.

  20. Prototype of network distributed control system for MLF/J-PARC

    NASA Astrophysics Data System (ADS)

    Nakatani, Takeshi; Nakajima, Kenji; Torii, Shuki; Bharoto; Higemoto, Wataru; Sato, Setsuo; Otomo, Toshiya; Arai, Masatoshi

    2006-11-01

    We have developed a prototype data acquisition and device control system for experiment instruments at the Material and Life science Facility (MLF)/Japan-Proton Accelerator Research Complex (J-PARC). The system employs distributed computing via Ethernet, client/server architecture, modular structure and a state machine. Communication between client and server software utilizes socket protocols over TCP/IP. We have deployed this prototype software in the network distributed control system by improving the data acquisition software used at KENS, introducing the system for the SWAN at KENS/KEK. It was kept in working order throughout 2 weeks of machine operation.

  1. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    SciTech Connect

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; March-Leuba, Jose A; Thurston, Carl; Hudson, Nathanael H.; Ireland, A.; Wysocki, A.

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, the capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.

  2. Performance evaluation of the Scattered particle Fiber Tracker for J-PARC E10 experiment

    NASA Astrophysics Data System (ADS)

    Nakada, Yoshiyuki; Sakaguchi, Atsushi; Hayakawa, Shuhei H.; Nakagawa, Manami; Oue, Kenichiro; Hayakawa, Tomonari; Miwa, Koji; Honda, Ryotaro; Akazawa, Yuya; Sugimura, Hitoshi; Hasegawa, Shoichi

    2014-09-01

    J-PARC E10 experiment was proposed to produce the neutron-rich Λ-hypernucleus Λ6H by using the 6 Li (π- ,K+) reaction at 1 . 2 GeV / c and to study its structure. The experiment was performed at the K1.8 beam line of J-PARC Hadron Experimental Facility. The Scattered particle Fiber Tracker (SFT) is a scintillating fiber tracker which was newly installed just downstream the target. In this experiment we required high intensity π- beams of typically 1 . 4 ×107 π /spill . So, we replace a tracking wire chamber with SFT to obtain more precise timing information and higher rate tolerance. SFT has x , u , v -planes constructed by scintillating fibers. The light signals from the scintillating fibers are read out by Multi Pixel Photon Counters (MPPCs). The Extended Analogue SiPM ReadOut Chip (EASIROC) system was used as readout electronics. The multi-hit TDC program has introduced in FPGA of the EASIROC system. We analyzed the time information of SFT and studied the influence of high counting rate upon the performance of SFT using the data of the E10 experiment. We report the results of the analysis.

  3. Design and performance of horizontal-type neutron reflectometer SOFIA at J-PARC/MLF

    NASA Astrophysics Data System (ADS)

    Yamada, N. L.; Torikai, N.; Mitamura, K.; Sagehashi, H.; Sato, S.; Seto, H.; Sugita, T.; Goko, S.; Furusaka, M.; Oda, T.; Hino, M.; Fujiwara, T.; Takahashi, H.; Takahara, A.

    2011-11-01

    Neutron reflectometry is a powerful method for investigating the surface and interfacial structures of materials in the spatial range from nanometers to sub-micrometers. At the Japan Proton Accelerator Research Complex (J-PARC), a high-intensity pulsed neutron beam is produced with a proton accelerator at 220kW, which will be upgraded to 1MW in future. Beamline 16 (BL16) at the Materials and Life Science Experimental Facility (MLF) in J-PARC is dedicated to a horizontal-type reflectometer, and in this beamline, neutrons are transported downward at two different angles, 2.2° and 5.7° , relative to the horizontal. In December 2008, we started to accept the neutron beam at BL16 with the old ARISA reflectometer relocated from the KENS facility, KEK, Japan; and we have now replaced it with the brand-new reflectometer SOFIA (SOFt Interface Analyzer). With a high-flux beam and instrumental upgrade, the observable reflectivity of SOFIA reaches around 10-7 within a few hours for specimens on 3" substrates. In this paper, we will present the design and performance of the SOFIA reflectometer, and discuss some preliminary results on the device development for further upgrade.

  4. Properties of the Vertical Deformation of the J-PARC Linac Tunnel

    NASA Astrophysics Data System (ADS)

    Morishita, Takatoshi

    The displacement of the accelerator components induces the beam losses so that the precise alignment is essentially important for the high-intensity hadron accelerates. All accelerator components in the J-PARC linac were realigned in summer 2011 to recover the displacements by the Tohoku earthquake in March 11th, 2011. However, the stability of the floor height became worth after that earthquake. The local settlement more than 1 mm was observed by the periodical (once a year) survey. The floor height is affected by the environmental conditions such as seasonal change, weather, earthquake, and so on. The amounts of these short-term movements are identified by continuously monitored floor height by the monitoring system. By the usual earthquake, the deformation seems random and negligibly small. The heavy rain tilts the floor about 0.1 mm/300 m in the N-S direction momentarily, however, which recovered gradually. The significant vertical deformation was observed by the long-term continuous monitoring for more than months. Then, the slow ground motion dominates the vertical deformation of the J-PARC linac tunnel.

  5. Evaluation of turbulence models in the PARC code for transonic diffuser flows

    NASA Technical Reports Server (NTRS)

    Georgiadis, N. J.; Drummond, J. E.; Leonard, B. P.

    1994-01-01

    Flows through a transonic diffuser were investigated with the PARC code using five turbulence models to determine the effects of turbulence model selection on flow prediction. Three of the turbulence models were algebraic models: Thomas (the standard algebraic turbulence model in PARC), Baldwin-Lomax, and Modified Mixing Length-Thomas (MMLT). The other two models were the low Reynolds number k-epsilon models of Chien and Speziale. Three diffuser flows, referred to as the no-shock, weak-shock, and strong-shock cases, were calculated with each model to conduct the evaluation. Pressure distributions, velocity profiles, locations of shocks, and maximum Mach numbers in the duct were the flow quantities compared. Overall, the Chien k-epsilon model was the most accurate of the five models when considering results obtained for all three cases. However, the MMLT model provided solutions as accurate as the Chien model for the no-shock and the weak-shock cases, at a substantially lower computational cost (measured in CPU time required to obtain converged solutions). The strong shock flow, which included a region of shock-induced flow separation, was only predicted well by the two k-epsilon models.

  6. Development of a coupled PARCS/RELAPS model of the Ringhals-3 PWR

    SciTech Connect

    Banati, J.; Demaziere, C.; Staalek, M.

    2006-07-01

    This paper deals with the development of a coupled PARCS/RELAPS model of the Swedish Ringhals-3 pressurized water reactor. The stand-alone PARCS and RELAP5 models are first presented. On the neutronic side, the dependence of the material constants on history effects, burnup, and instantaneous conditions is accounted for, and the full heterogeneity of the core is thus taken into account. The reflectors are also explicitly represented. On the thermal-hydraulic side, each of the 157 fuel assemblies is modeled. The model is furthermore able to handle possible asymmetrical conditions of the flow field between the loops. The coupling between the two codes is then reported, with emphasis on the mapping between the hydrodynamic/heat structures and the neutronic nodes. Preliminary coupling tests for steady-state calculations were successfully performed and comparisons against plant measured data demonstrate a very good agreement of the model with the measurements. The coupled model will be later on used for analyzing the consequences of the power up-rate planned for this reactor, via the simulation of a few limiting transients. (authors)

  7. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    DOE PAGES

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; March-Leuba, Jose A; Thurston, Carl; Hudson, Nathanael H.; Ireland, A.; Wysocki, A.

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, themore » capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.« less

  8. Progress of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK/E36 Collaboration

    2015-10-01

    The TREK/E36 experiment is being carried out at J-PARC to provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model. Simultaneously it will be sensitive to light U(1) gauge bosons and sterile neutrinos below 300 MeV/c2, which could be associated with dark matter or explain established muon-related anomalies such as the muon g - 2 and the proton radius puzzle. The experiment has been set up at the J-PARC K1.1BR kaon beamline since fall 2014, it has been fully commissioned in spring 2015, and is now ready to accumulate production data anticipated in fall 2015. It uses a scintillating fiber target to stop a beam of up to 1.2 Million K+ per spill. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and particle identification systems. The status and recent progress of the experiment will be presented. Supported by DOE DE-SC00013941.

  9. Three-dimensional spiral injection scheme for the g-2/EDM experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Iinuma, Hiromi; Nakayama, Hisayoshi; Oide, Katsunobu; Sasaki, Ken-ichi; Saito, Naohito; Mibe, Tsutomu; Abe, Mitsushi

    2016-10-01

    A newly developed three-dimensional spiral injection scheme for beam insertion into a solenoidal storage ring is reported. A new planned muon g-2/EDM experiment at J-PARC aims to measure g - 2 to a factor of 5 better statistical precision and a factor of 100 better sensitivity for the electric dipole moment (EDM) measurement compared to previous experiments. The J-PARC experiment will use a 3-T MRI solenoid magnet as the muon storage ring with a 0.66 m diameter to achieve a 1-ppm level of local uniformity. The previous g - 2 injection scheme is not applicable for beam injection into a small ring. The new scheme provides a smooth injection utilizing a radial solenoidal fringe field, without causing an error field in the storage volume. The expected storage efficiency is 80% and over, which is to be compared to 3.5% for the previous g - 2 experiment. In addition, the ability to control the storage plane is important for the EDM measurement. In this paper, we introduce the conceptual design and required beam parameters in terms of Twiss functions and the expected injection efficiency.

  10. Outline for the Winter T-PARC (THORPEX Pacific-Asia Regional Campaign)

    NASA Astrophysics Data System (ADS)

    Asuma, Y.; Yamanouchi, T.; Toth, Z.

    2009-12-01

    For the purpose of improvement of 1-14 day high impact weather forecast, the wintertime THORPEX Pacific-Asia Regional Campaign (Winter T-PARC) was carried out by the lead organization of National Oceanic and Atmospheric Administration in United States from 12 January to the end of February 2008. Main observation platforms were enhanced upper air soundings in Siberia, Russia, two aircrafts (G-IV and C-130) for drop-sonde soundings. NOAA G-IV was located at Yokota AB in Tokyo, Japan and USAF C-130 was at Anchorage in Alaska, USA. As the rapidly deepening low pressure systems in the Northwestern Pacific region strongly affect downstream regions, such as Alaska, Arctic and entire North-American continent, they have a great contribution to the improvement of the forecasting in the Unite Sates and Canada. Winter T-PARC is assigned as a part of International Polar Year (IPY) program in the Unites States. National Institute of Polar Research in Japan supports the Winter T-PARC as a part of Japanese IPY activity. Using NCEPFNL dataset, temperature and moisture transportations and storm activities were analyzed over the North Pacific and Arctic regions from December 2008 to March 2009. As shown in Yoshida and Asuma (2004) and Kuwano-Yoshida and Asuma (2008), explosively deepening cyclones in the Northwestern Pacific region had distinct seasonal variations. That is, cyclones rapidly developed near the east coast of the Eurasian Continent (OJ cyclones) in December, moved quickly straightforward to the East in January (PO-L cyclones) and formed over the East China Sea where the south of Japan, moved to the Northward and developed over the east of Hokkaido (PO-O cyclones) in February and March. Figure shows monthly low pressure systems and their tracks in the Arctic region. Large amounts of heat and moisture flow into the Arctic region from the lower and mid latitudes through the Bearing Straight as well as the Norwegian Sea. Storms entered and traveled into the Arctic region

  11. ACCELERATORS: Tuning of RF amplitude and phase for the drift tube linac in J-PARC

    NASA Astrophysics Data System (ADS)

    Shen, Guo-Bao; Masanori, Ikegami

    2009-07-01

    The J-PARC linac has three DTL tanks to accelerate the negative hydrogen ions from 3 MeV to 50 MeV. The RF phase and amplitude are adjusted for each cavity with a phase scan method within the accuracy of 1? in phase and 1% in amplitude. The experimental results show a remarkable agreement with the numerical model within a sufficient margin in the tuning of the last two DTL tanks. However, a notable discrepancy between the experiment and the numerical model is seen in the tuning of the first DTL tank. After studying with a three-dimensional multi-particle simulation, the generation of the low energy component and the pronounced filamentation are identified as the main causes of the discrepancy. The optimization of the tuning scheme is also discussed to attain the tuning goal accuracy for the first DTL tank.

  12. Diamond detector for beam profile monitoring in COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    &Cbreve; erv, M.; Sarin, P.; Pernegger, H.; Vageeswaran, P.; Griesmayer, E.

    2015-06-01

    We present the design and initial prototype results of a proton beam profile monitor for the COMET experiment at J-PARC. The goal of COMET is to look for charged lepton flavor violation by direct μ to e conversion at a sensitivity of 10-19. The 8 GeV proton beam pulsed at 100 ns with 1010 protons/s will be used to create muons through pion production and decay. In the final experiment, the proton flux will be raised to 1014 protons/s to increase the sensitivity. These requirements of harsh radiation tolerance and fast readout make diamond a good choice for constructing a beam profile monitor in COMET. We present first results of the characterization of single crystal diamond (scCVD) sourced from a new company 2A SYSTEMS Singapore. Our measurements indicate excellent charge collection and high carrier mobility down to cryogenic temperatures.

  13. Double Hypernuclei Experiment with Hybrid Emulsion Method at J-PARC

    NASA Astrophysics Data System (ADS)

    Ekawa, Hiroyuki

    Double hypernuclei are important probes to study the system with strangeness S = -2. Several emulsion experiments had been performed to search for them. We are planning a new experiment to search for double hypernuclei at the K1.8 beam line in the Hadron Experimental Facility (J-PARC E07 experiment). Ξ- tracks in the emulsion plates and SSD will be automatically connected by a hybrid method. The estimated Ξ- stopped statistics is 10 times as high as that of the KEK E373 experiment. Discoveries of 10 new double hypernuclear species are expected, which enable us to discuss binding energy in terms of mass number dependence. On the other hand, we will also observe X rays from Ξ- atoms with a germanium detector array installed close to theemulsion plates by tagging Ξ- stopped events. This will be the first measurement to give information on the Ξ- potential at the nuclear surface region.

  14. Overall Scanning Method for the J-PARC E07 Experiment

    NASA Astrophysics Data System (ADS)

    Yoshida, Junya; Nakazawa, Kazuma; Than Tint, Khin; Kyaw Soe, Myint; Kinbara, Shinji; Mishina, Akihiro; Endo, Yoko; Itoh, Hiroki; Kobayashi, Hidetaka

    A new scanning method named "Overall scanning" will be applied for J-PARC E07's emulsion plates to collect alpha decays which are calibration sources for range-energy relation in emulsion, rapidly. We carried out an operation of alpha search with current Overall scanning technology by E373's emulsion. About 100 alpha rays were selected and measured in 17 days in 30 mm*110 mm*0.45 mm volume of the plate with less man-power than before. Development of advanced image process and scanning software is on-going for speeding up. Besides, Overall scanning method will be applied to search for more events after regular analysis with hybrid method.

  15. Muonium production target for the muon g-2/EDM experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kanda, Sohtaro

    2014-08-01

    There is more than three standard-deviations discrepancy between measurement and theoretical prediction of the muon anomalous magnetic moment. We are going to measure the precision value of muon g - 2 and search for physics beyond standard model. In addition, we can search for muon EDM which violates CP symmetry. CP violation in charged lepton sector is currently not found. We are developing the 'Ultra Cold Muon Beam' instead of tertiary muon beam with electric focusing. Ultra cold muon is realized by laser ionization of muonium (bound state of a muon and an electron) from the production target. Increase of muonium yield is essential for our experimental goal; 0.1ppm statistical precision. Muonium production experiment at J-PARC MLF MUSE is planned in 2012 autumn. In this paper, we discuss the development of muonium production target and positron detector for the study.

  16. Human rights assessment in Parc Jean Marie Vincent, Port-au-Prince, Haiti.

    PubMed

    Cullen, Kimberly A; Ivers, Louise C

    2010-01-01

    Months after a 7.0 magnitude earthquake hit Port-au-Prince, Haiti, over one million remain homeless and living in spontaneous internally displaced person (IDP) camps. Billions of dollars from aid organizations and government agencies have been pledged toward the relief effort, yet many basic human needs, including food, shelter, and sanitation, continue to be unmet. The Sphere Project, "Humanitarian Charter and Minimum Standards in Disaster Response," identifies the minimum standards to be attained in disaster response. From a human rights perspective and utilizing key indicators from the Sphere Project as benchmarks, this article reports on an assessment of the living conditions approximately 12 weeks after the earthquake in Parc Jean Marie Vincent, a spontaneous IDP camp in Port-au-Prince. A stratified random sample of households in the camp, proportionate to the number of families living in each sector, was selected. Interview questions were designed to serve as "key indicators" for the Sphere Project minimum standards. A total of 486 interviews were completed, representing approximately 5% of households in each of the five sectors of the camp. Our assessment identified the relative achievements and shortcomings in the provision of relief services in Parc Jean Marie Vincent. At the time of this survey, the Sphere Project minimum standards for access to health care and quantity of water per person per day were being met. Food, shelter, sanitation, and security were below minimum accepted standard and of major concern. The formal assessment reported here was completed by September 2010, and is necessarily limited to conditions in Haiti before the cholera outbreak in October.

  17. A development of HBD for the J-PARC E16 experiment

    NASA Astrophysics Data System (ADS)

    Aoki, Kazuya; En'yo, Hideto; Gunji, Taku; Hamagaki, Hideki; Kanaya, Junpei; Komatsu, Yusuke; Masumoto, Shinichi; Ozawa, Kyoichiro; Sato, Tsutomu; Sekimoto, Michiko; Tsuji, Tomoya; Utsunomiya, Kazuki; Watanabe, Yosuke; Yokkaichi, Satoshi

    2011-02-01

    Spontaneous breaking of the chiral symmetry is considered to be the origin of hadron mass. The chiral symmetry is expected to be (partially) restored in finite density and the hadron mass is predicted to decrease, even at the normal nuclear density. The J-PARC E16 experiment was proposed to investigate the origin of the mass through the mass modification of vector mesons in a finite density environment. The masses of vector mesons, which are produced in p+A reactions, are measured through the electron-positron decays. A Cherenkov detector with a large acceptance and with fine segmentations is required for the electron identification. HBD is ideal for the purpose; it is a mirror-less, windowless Cherenkov detector with a stack of Gas Electron Multipliers (GEMs) on top of which CsI is evaporated. CF 4 acts as amplification gas and as Cherenkov radiator. We have developed a prototype of HBD for the J-PARC E16 experiment. It is constructed with two layers of Liquid-Crystal-Polymer (LCP) GEMs with a thickness of 100 μm each, on the uppermost surface CsI is evaporated. The use of thicker GEMs leads to a larger gain at the first stage and to tolerance to sparks, compared to regular 50 μm Kapton-GEMs. With a threshold at ˜16 electrons, a pion rejection factor of 100 can be achieved, which is required for the E16 experiment. A beam test was performed with a positron beam and the prototype successfully detected the Cherenkov radiation. The number of photoelectrons observed was about 5-6. Although these results were not satisfactory to reach a pion rejection factor of 100 with a reasonable efficiency at this point, improvements towards the goal are expected from photocathode and gas purity.

  18. Search for New Physics with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi; TREK/E36 Collaboration

    2016-03-01

    The E36 experiment conducted at J-PARC in Japan will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model (SM). The SM prediction for the ratio of leptonic K+ decays is very precise with an uncertainty of △RK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide clear indication of New Physics beyond the SM. The detector apparatus allows sensitivity to search for light U (1) gauge bosons and sterile neutrinos below 300 MeV /c2 , which could be associated with dark matter or explain established muon-related anomalies such as the muon g - 2 value, and perhaps the proton radius puzzle. The experiment was set up at the J-PARC K1.1BR kaon beamline in the fall of 2014, fully commissioned in the spring of 2015 and completed production data accumulation in Dec 2015. A scintillating fiber target was used to stop a beam of up to 1.2 Million K+ per spill. The K+ products were detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a CsI(TI) photon detector and particle ID systems. The status of the data analysis will be presented. This work has been supported by DOE awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  19. Wintertime component of the THORPEX Pacific-Asian Regional Campaign (T-PARC)

    NASA Astrophysics Data System (ADS)

    Song, Y.; Toth, Z.; Asuma, Y.; Reynolds, C.; Lngland, R.; Szunyogh, I.; Colle, B.; Chang, E.; Doyle, C.; Kats, A.

    2009-04-01

    The winter component of the T-PARC is an international field project that aims at improving high impact weather event forecasts for North America. The main objective is to understand how perturbations from the tropics, Eurasia and polar fronts travel through waveguide and turn into high impact weather events. Through adaptive observations by using manned aircrafts (NOAA G-IV and US Air force C-130s) and Russian rawinsonde network over data sparse regions, it is expected that accurate initial conditions will improve the numerical weather forecasts. Non-adaptive aircraft measurements over the Pacific Rim and part of India are also deployed through E-AMDAR program, which is expected to improve the background field over Asia where perturbations are initiated. The campaign is led by NOAA and joined by agencies and universities from US, Canada, Mexico, Japan, ECWMF, and Russia. While most observational data will be assimilated by operational centers to improve real time numerical weather predictions, post field studies will focus on aspects such as: data impact on forecast and analysis, dry and moist processes that affect the formation and propagation of perturbations, meso-scale storm structure, error growth, forecast "busts" under certain atmospheric regimes, and socio-economic applications such as costs and benefits of improved forecasts and their use by the public for high impact weather events. In particular, a Winter Olympics demonstration project (February 12 - February 28) is expected to be a test bed during winter T-PARC for real user outreach and application purposes. Effectiveness of existing targeting methods as well as new targeting methods in the 3-5 day lead time range will be pursued and other aspects related to data assimilation and numerical forecasts (both deterministic and ensemble forecasts) will be investigated within this project as well.

  20. HUMAN RIGHTS ASSESSMENT IN PARC JEAN MARIE VINCENT, PORT-AU-PRINCE, HAITI

    PubMed Central

    Cullen, Kimberly A.; Ivers, Louise C.

    2014-01-01

    Months after a 7.0 magnitude earthquake hit Port-au-Prince, Haiti, over one million remain homeless and living in spontaneous internally displaced person (IDP) camps. Billions of dollars from aid organizations and government agencies have been pledged toward the relief effort, yet many basic human needs, including food, shelter, and sanitation, continue to be unmet. The Sphere Project, “Humanitarian Charter and Minimum Standards in Disaster Response,” identifies the minimum standards to be attained in disaster response. From a human rights perspective and utilizing key indicators from the Sphere Project as benchmarks, this article reports on an assessment of the living conditions approximately 12 weeks after the earthquake in Parc Jean Marie Vincent, a spontaneous IDP camp in Port-au-Prince. A stratified random sample of households in the camp, proportionate to the number of families living in each sector, was selected. Interview questions were designed to serve as “key indicators” for the Sphere Project minimum standards. A total of 486 interviews were completed, representing approximately 5% of households in each of the five sectors of the camp. Our assessment identified the relative achievements and shortcomings in the provision of relief services in Parc Jean Marie Vincent. At the time of this survey, the Sphere Project minimum standards for access to health care and quantity of water per person per day were being met. Food, shelter, sanitation, and security were below minimum accepted standard and of major concern. The formal assessment reported here was completed by September 2010, and is necessarily limited to conditions in Haiti before the cholera outbreak in October. PMID:21178190

  1. Development of Single-Sided Silicon Detectors in the Emulsion-Hybrid System at J-PARC

    NASA Astrophysics Data System (ADS)

    Lee, J. Y.; Ahn, J. K.; Ekawa, H.; Han, Y. C.; Hasegawa, S.; Hayakawa, S.; Hayakawa, T.; Hosomi, K.; Hwang, S. H.; Imai, K.; Ito, K.; Kim, M. H.; Kim, S. H.; Kiuchi, R.; Moon, T. J.; Nakazawa, K.; Oue, K.; Sako, H.; Sato, S.; Sugimura, H.; Tanida, K.; Watabe, T.

    A new single-sided silicon micro-strip detector (SSD) is being developed at the J-PARC K1.8 beam line for an emulsion-counter hybrid experiment (J-PARC E07). The SSD will be mainly used for vetex measurements in emulsion plates. Two prototypes of SSD have been fabricated to check the performance of the circuit board and silicon sensors. The first prototype consists of only one layer of a silicon sensor whereas the second prototype consists of two layers of silicon sensors. The final product will be a stack of 4 layers of silicon sensors in the order of X-Y-X-Y. The first and second prototypes of SSD have been tested and the final product will be fabricated based on the test result.

  2. Upgrade of PARC2D to include real gas effects. [computer program for flowfield surrounding aeroassist flight experiment

    NASA Technical Reports Server (NTRS)

    Saladino, Anthony; Praharaj, Sarat C.; Collins, Frank G.; Seaford, C. Mark

    1990-01-01

    This paper presents a description of the changes and additions to the perfect gas PARC2D code to include chemical equilibrium effects, resulting in a code called PARCEQ2D. The work developed out of a need to have the capability of more accurately representing the flowfield surrounding the aeroassist flight experiment (AFE) vehicle. Use is made of the partition function of statistical mechanics in the evaluation of the thermochemical properties. This approach will allow the PARC code to be extended to thermal nonequilibrium when this task is undertaken in the future. The transport properties follow from formulae from the kinetic theory of gases. Results are presented for a two-dimensional AFE that compare perfect gas and real gas solutions at flight conditions, showing vast differences between the two cases.

  3. 1-MW Beam Operation Scenario of the J-PARC 3-GeV Rapid Cycling Synchrotron

    NASA Astrophysics Data System (ADS)

    Hotchi, Hideaki

    The J-PARC 3-GeV Rapid Cycling Synchrotron initiates the final stage of beam commissioning aiming for the design output beam power of 1 MW from Oct. 2014 after completing the injector linac upgrade. In this paper, emittance growth and beam loss issues for the coming 1-MW beam operation will be discussed together with their possible mitigation scenarios, based on numerical simulations.

  4. Ribbon thickness dependence of the Magnetic Alloy core characteristics in the accelerating frequency region of the J-PARC synchrotrons

    NASA Astrophysics Data System (ADS)

    Nomura, M.; Shimada, T.; Tamura, F.; Yamamoto, M.; Hara, K.; Hasegawa, K.; Ohmori, C.; Takata, K.; Toda, M.; Yoshii, M.; Schnase, A.

    2014-06-01

    We employ Magnetic Alloy (MA) core loaded RF cavities for the J-PARC synchrotrons to achieve a high field gradient. The MA core has a laminated structure of 18 μm thick ribbon layers. We have been developing high shunt impedance MA cores to prepare for an increase of beam power. At low frequencies, it is well known that the eddy current loss in the ribbon is proportional to the square of the ribbon thickness. The MA core shunt impedance can be increased by using thinner ribbons. On the other hand, at high frequencies, the MA core magnetic characteristics are largely different from low frequencies. Using thinner ribbons might be effective to increase the MA core shunt impedance in the accelerating frequency region of the J-PARC synchrotrons. We reviewed the theoretical calculations of the ribbon thickness dependence of the MA core magnetic characteristics and we derived the ribbon thickness dependence from measured data. The measured data show that the MA core shunt impedance is inversely proportional to the ribbon thickness in the accelerating frequency region of the J-PARC synchrotrons, which is consistent with our calculations.

  5. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK Collaboration

    2014-09-01

    The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  6. PARC3D calculations of the F/A-18A HARV inlet vortex generators

    NASA Technical Reports Server (NTRS)

    Podleski, Steve D.

    1995-01-01

    NASA Lewis Research Center is currently engaged in a research effort as a team member of the High Alpha Technology Program within the NASA agency. This program uses a specially-equipped F/A-18A aircraft called the High Alpha Research Vehicle (HARV), in an effort to improve the maneuverability of high performance military aircraft at low-subsonic-speed, high-angle-of-attack conditions. The overall objective of the NASA Lewis effort is to develop inlet analysis technology towards efficient airflow delivery to the engine during these maneuvers. One portion of this inlet analysis technology uses computational fluid dynamics to predict installed inlet performance. Most of the F/A-18A HARV geometry, which includes the ramp/splitter plate, side diverter and slot, inlet lip and upper diverter, and deflected leading-edge flap has been modeled. The empennage and rear fuselage have not. A pair of vortex generators located on the bottom wall of the inlet were not modeled initially. These vortex generators were installed to alleviate any flow separation that may be induced by the wheel well protrusion into the inlet wall. Calculations completed with the PARC3D code showed that the pressure recovery has been underpredicted and the flow distortion over-predicted. To improve the correlation of PARC3D predictions with flight and wind tunnel tests, the vortex generators were included in the grid geometry and the results are presented in this report. The grid totals 27 blocks or 1.3 million grid points for the half model, which includes the vortex generator grid blocks. Two flight cases were calculated, a high speed case with a Mach number of 0.8 and angle of attack of 3.4; and a low speed case with a Mach number of 0.43 and angle of attack of 32.2. The vortex generators have a significant effect on the inlet boundary layers at high speed, low angle of attack; and have no effect at low speed, high angle of attack.

  7. SUPERCONDUCTING COMBINED FUNCTION MAGNET SYSTEM FOR J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    OGITSU, T.; AJIMA, Y.; ANERELLA, M.; ESCALLIER, J.; GANETIS, G.; GUPTA, R.; HAGEDOM, D.; HARRISON, M.; HIGASHI, N.; IWAMOTO, Y.; ICHIKAWA, A.; JAIN, A.; KIMURA, N.; KOBAYASHI, T.; MAKIDA, Y.; MURATORE, J.; NAKAMOTO, T.; OHHATA, H.; TAKASAKI, N.; TANAKA, K.; TERASHIMA, A.; YAMOMOTO, A.; OBANA, T.; PARKER, B.; WANDERER, P.

    2004-10-03

    The J-PARC Neutrino Experiment, the construction of which starts in JFY 2004, will use a superconducting magnet system for its primary proton beam line. The system, which bends the 50 GeV 0.75 MW proton beam by about 80 degrees, consists of 28 superconducting combined function magnets. The magnets utilize single layer left/right asymmetric coils that generate a dipole field of 2.6 T and a quadrupole field of 18.6 T/m with the operation current of about 7.35 kA. The system also contains a few conduction cooled superconducting corrector magnets that serve as vertical and horizontal steering magnets. All the magnets are designed to provide a physical beam aperture of 130 mm in order to achieve a large beam acceptance. Extensive care is also required to achieve safe operation with the high power proton beam. The paper summarizes the system design as well as some safety analysis results.

  8. Design and delivery of beam monitors for the energy-upgraded linac in J-PARC

    NASA Astrophysics Data System (ADS)

    Miura, Akihiko; Ouchi, Nobuo; Oguri, Hidetomo; Hasegawa, Kazuo; Miyao, Tomoaki; Ikegami, Masanori

    2015-02-01

    In the J-PARC (Japan Proton Accelerator Research Complex) linac, an energy-upgrade project has started to achieve a design beam power of 1 MW at the exit of the downstream synchrotron. To account for the significant beam parameter upgrades, we will use the newly-fabricated beam monitors for the beam commissioning. This paper discusses the design and assembly of the beam position monitor, phase monitor, current monitor, transverse profile monitor, and beam loss monitor for the energy-upgraded linac. We periodically installed the newly-fabricated monitors for the upgraded beam line, as well as for longitudinal matching, because of the frequency jump between the original RF cavity and the newly-developed cavity. We employed two debunchers to correct for momentum spread and jitter. To account for the new debunchers, we fabricated and installed additional pairs of phase monitors in order to tune the debunchers to the adequate RF set point. Finally, we propose commissioning plans to support the beam monitor check. We will begin to establish the 181-MeV operation to confirm the proper functioning of beam monitors. Herein, we will examine the response to changes of the knobs that control the quadrupole magnets after the energy upgrade. After proper functioning of the beam monitors is confirmed, we will use the new beam monitors to establish the 400-MeV acceleration operation.

  9. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK/E36 Collaboration

    2015-04-01

    The TREK/E36 experiment will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model. Simultaneously it will search for light U(1) gauge bosons and sterile neutrinos below 300 MeV/c2, which could be associated with dark matter or explain established muon-related anomalies such as the muon anomalous magnetic moment and the proton radius puzzle. The experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. It uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  10. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    DOE PAGES

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; Aronson, A.; Diamond, D.; Yarsky, P.

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculationmore » pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.« less

  11. PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    ScienceCinema

    Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

    2016-07-12

    'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  12. Analysis of the OECD/NRC BWR Turbine Trip Transient Benchmark with the Coupled Thermal-Hydraulics and Neutronics Code TRAC-M/PARCS

    SciTech Connect

    Lee, Deokjung; Downar, Thomas J.; Ulses, Anthony; Akdeniz, Bedirhan; Ivanov, Kostadin N.

    2004-10-15

    An analysis of the Peach Bottom Unit 2 Turbine Trip 2 (TT2) experiment has been performed using the U.S. Nuclear Regulatory Commission coupled thermal-hydraulics and neutronics code TRAC-M/PARCS. The objective of the analysis was to assess the performance of TRAC-M/PARCS on a BWR transient with significance in two-phase flow and spatial variations of the neutron flux. TRAC-M/PARCS results are found to be in good agreement with measured plant data for both steady-state and transient phases of the benchmark. Additional analyses of four fictitious extreme scenarios are performed to provide a basis for code-to-code comparisons and comprehensive testing of the thermal-hydraulics/neutronics coupling. The obtained results of sensitivity studies on the effect of direct moderator heating on transient simulation indicate the importance of this modeling aspect.

  13. Closeout Report - Search for Time Reversal Symmetry Violation with TREK at J-PARC

    SciTech Connect

    Kohl, Michael

    2015-04-15

    This DOE Early Career Award has enabled Dr. Michael Kohl to take on and expand his leadership roles in several projects such as TREK@J-PARC, OLYMPUS@DESY, MUSE@PSI, and in the experimental program in Hall C at Jefferson Lab. Dr. Kohl has successfully accomplished several items: (i) Preliminary results from SANE (E08-003) at Jefferson Lab: Former HU graduate student Anusha Liyanage has pursued her PhD research on SANE. Her analysis of the elastic ep scattering data has resulted in the extraction of the proton electric-to-magnetic form factor ratio from double spin asymmetries at the highest momentum transfer to date. The results are almost final and a publication is in preparation. (ii) Approval of TREK/E36 for running, preparation of simulation and analysis: the TREK experiment has been stage-II approved in fall 2013, has been mounted on the hall floor from November 2014 to April 2015, has been commissioned in April-June 2015 and is scheduled to run in fall 2015. The group has contributed significantly with simulations and magnetic field map calculations, has investigated the sensitivity of TREK to new light neutral particles, and contributed substantially to the mounting and commissioning of the experiment. (iii) Running of OLYMPUS and analysis: Under Dr. Kohl's leadership as spokesman, the OLYMPUS experiment has completed data taking beginning of 2013; calibrations and analysis have been well underway, with results to be expected in the course of 2015. (iv) Operation of GEM detectors at OLYMPUS and MUSE: The GEM telescopes built for OLYMPUS luminosity monitoring with forward-angle ep elastic scattering have been operated successfully, have meanwhile been relocated to PSI, and have been re-commissioned as beam particle trackers for the PSI secondary beams for MUSE. (v) Trained and prepared postdocs and graduate students for their future careers. Two postdocs from Dr. Kohl's group (Dr. Juergen Diefenbach and Dr. Peter Monaghan) have found permanent academic

  14. Rod-filter-field optimization of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second-stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). Although rod-filter-field (RFF) is indispensable and one of the most beam performance dominative parameters for the RF-driven H{sup −} ion source with the internal-antenna, the procedure to optimize it is not established. In order to optimize the RFF and establish the procedure, the beam performances of the J-PARC source with various types of rod-filter-magnets (RFMs) were measured. By changing RFM’s gap length and gap number inside of the region projecting the antenna inner-diameter along the beam axis, the dependence of the H{sup −} ion beam intensity on the net 2MHz-RF power was optimized. Furthermore, the fine-tuning of RFM’s cross-section (magnetmotive force) was indispensable for easy operation with the temperature (T{sub PE}) of the plasma electrode (PE) lower than 70°C, which minimizes the transverse emittances. The 5% reduction of RFM’s cross-section decreased the time-constant to recover the cesium effects after an slightly excessive cesiation on the PE from several 10 minutes to several minutes for T{sub PE} around 60°C.

  15. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC

    PubMed Central

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-01-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm3 in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4–4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm3) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research. PMID:26937237

  16. Mass production of the large-sized nuclear plate for J-PARC E07

    NASA Astrophysics Data System (ADS)

    Ito, Hiroki; Nakazama, Kazuma; Hoshino, Kaoru; Yoshida, Jyunya; Tint, Khin Than; Soe, Mint Kyaw; Kinbara, Shinji; Mishina, Akihiro; Endo, Yoko; Kobayashi, Hidetaka; J-PARC E07 Collaboration

    2014-09-01

    In J-PARC E07, about 102 double lambda hypernuclei will be detected, which is 10 times or more than that of the KEK PS-E373 experiment. Therefore, it is necessary for large-scale emulsion plates to avoid time-consuming job for exchange emulsion stack in beam exposure. We also use huge amount of emulsion gel with weight of 2.1 t, which is about 3 times' quantity used for E373. Nuclear emulsion plate is made of photographic emulsion gel as a dry film. Melted gel in 40°C is poured on a thin polystyrene film in the size of 710 × 700 mm2. These sheets were dried slowly for two days in drying cabinet under 28°C and RH. 75%. After drying, the surface was coated by thin gelatin layer with 0.3 μm thickness. Regarding the 2nd face, it was poured and coated in the same manner. Finally we dry it well under 25°C and RH. 60% and cut into four 350 × 345 mm2 plates. We evaluated the performance about these plates. The length of upper, lower, right-hand and left-hand side are 345.08 +/- 0.05 mm, 345.23 +/- 0.13 mm, 350.03 +/- 0.04 mm, and 350.80 +/- 0.05 mm, respectively. The density is 3.676 +/- 0.032 g/cm3, enough quality for the experiment.

  17. Les emissions de radio et de television en langue francaise pour l'enseignement du francais et pour la diffusion de la culture francaise (French Language Radio and Television Broadcasts for French Language Instruction and for the Diffusion of the French Culture).

    ERIC Educational Resources Information Center

    Thureau, Josiane; Koesten, Leo

    1980-01-01

    Provides a listing of radio and television programs that teach French language and civilization, the result of two worldwide surveys, one conducted by "Le Francais dans le Monde," the other by the French Foreign Affairs Ministry. The programs are listed alphabetically by country and accompanied by a brief description. (MES)

  18. DEVELOPMENT OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE PROTON TRANSPORT LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    NAKAMOTO, T.; AJIMA, Y.; FUJII, Y.; HIGASHI, N.; ICHIKAWA, A.; KIMURA, N.; KOBAYASHI, T.; MAKIDA, Y.; OGITSU, T.; OHHATA, H.; OKAMURA, T.; SASAKI, K.; ET AL.

    2005-05-16

    Superconducting combined function magnets will be utilized for the 50 GeV, 750 kW proton beam line for the J-PARC neutrino experiment. The magnet is designed to provide a dipole field of 2.6 T combined with a quadrupole field of 19 T/m in a coil aperture of 173.4 mm at a nominal current of 7345 A. Two full-scale prototype magnets to verify the magnet performance were successfully developed. The first prototype experienced no training quench during the excitation test and good field quality was confirmed.

  19. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

    NASA Astrophysics Data System (ADS)

    Shibata, T.; Nishida, K.; Mochizuki, S.; Mattei, S.; Lettry, J.; Hatayama, A.; Ueno, A.; Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Naito, F.

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  20. The Residual Gas Ionization Profile Monitor in the J-PARC 3-GeV Rapid Cycling Synchrotron

    NASA Astrophysics Data System (ADS)

    Harada, Hiroyuki; Kato, Shinichi

    The residual gas Ionization Profile Monitor (IPM) is developed in the J-PARC 3-GeV RCS. The IPM is a non-destructive beam profile monitor to observe a circulating transverse beam profile in the ring. It is very important to observe the beam profile turn-by-turn in the ring for identification of the beam loss and emittance growth source because beam loss is always issue in increasing the beam power in terms of keeping hands on maintenance. The IPM has been continuously upgraded since 2008. The recent progress of the IPM is reported together with the outline of IPM system.

  1. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source.

    PubMed

    Shibata, T; Nishida, K; Mochizuki, S; Mattei, S; Lettry, J; Hatayama, A; Ueno, A; Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Naito, F

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna. PMID:26932010

  2. DESIGN OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    WANDERER,P.; ET AL.

    2003-06-15

    Superconducting combined function magnets will be utilized for the 50GeV-750kW proton beam line for the J-PARC neutrino experiment and an R and D program has been launched at KEK. The magnet is designed to provide a combined function with a dipole field of 2.59 T and a quadrupole field of 18.7 T/m in a coil aperture of 173.4 mm. A single layer coil is proposed to reduce the fabrication cost and the coil arrangement in the 2-D cross-section results in left-right asymmetry. This paper reports the design study of the magnet.

  3. Study of the analyzer crystals for use in the near-backscattering spectrometer DNA at J-PARC

    NASA Astrophysics Data System (ADS)

    Takahashi, Nobuaki; Shibata, Kaoru; Sato, Taku J.; Kawakita, Yukinobu; Tsukushi, Itaru; Metoki, Naoto; Nakajima, Kenji; Arai, Masatoshi

    2009-02-01

    The DNA is a near-backscattering instrument that will be installed at the J-PARC neutron facility. Several kinds of analyzer crystals are planned to be installed in it and include PG(0 0 2), Ge(3 1 1), Si(1 1 1) and Si(3 1 1). The Si analyzers will use perfect crystals. Conversely, with the PG and the Ge analyzers, the plan is to utilize mosaic crystals. We have examined the reflecting intensities and mosaic spreads of hot-pressed and as-cut Ge and PG crystals of several qualities using neutron scattering measurements.

  4. Experimental verification of equilibrium para-hydrogen levels in hydrogen moderators irradiated by spallation neutrons at J-PARC

    NASA Astrophysics Data System (ADS)

    Teshigawara, M.; Harada, M.; Tatsumoto, H.; Aso, T.; Ohtsu, K.; Takada, H.; Futakawa, M.; Ikeda, Y.

    2016-02-01

    By sampling gaseous hydrogen from a circulating liquid hydrogen loop for Laser Raman spectroscopy, we measured the para-/ortho-hydrogen fractions in liquid hydrogen under neutron irradiation for the first time to identify whether irradiated hydrogen has an elevated ortho-hydrogen fraction. This measurement indicates that para-hydrogen equilibrium persists at 300 kW proton power in the presence of an iron(III) oxide hydroxide [Fe(OH)3] catalyst. The measurements will be repeated as the power at the Japan Proton Accelerator Research Complex (J-PARC) increases to the MW level.

  5. Emittance measurements for optimum operation of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The transverse emittances of the source were measured with various conditions to find out the optimum operation conditions minimizing the horizontal and vertical rms normalized emittances. The transverse emittances were most effectively reduced by operating the source with the plasma electrode temperature lower than 70°C. The optimum value of the cesium (Cs) density around the beam hole of the plasma electrode seems to be proportional to the plasma electrode temperature. The fine control of the Cs density is indispensable, since the emittances seem to increase proportionally to the excessiveness of the Cs density. Furthermore, the source should be operated with the Cs density beyond a threshold value, since the plasma meniscus shape and the ellipse parameters of the transverse emittances seem to be changed step-function-likely on the threshold Cs value.

  6. Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae

    PubMed Central

    Ferrándiz, María José; Fenoll, Asunción; Liñares, Josefina; De La Campa, Adela G.

    2000-01-01

    We have analyzed genetically three clinical isolates (3180, 3870, and 1244) of Streptococcus pneumoniae with high-level ciprofloxacin resistance. Isolates 3180 and 3870 were atypical because of their insolubility in deoxycholate. However, they hybridized specifically with pneumococcal autolysin and pneumolysin gene probes and have typical pneumococcal atpC and atpA gene sequences. Analysis of the complete sequences of the parC and gyrA genes revealed total variations of 8 and 8.7% (isolate 3180) and 7.4 and 3.6% (isolate 3870), respectively, compared to the wild-type strain R6 sequence. The variations observed between the sequences of R6 and isolate 1244 were less than 0.9%. The structure of the gyrA and parC genes from isolates 3180 and 3870 was organized in sequence blocks that show different levels of divergence, suggesting a pattern of recombination. These results are evidence for recombination at the fluoroquinolone target genes in clinical isolates of S. pneumoniae. The genetically related viridans group streptococci could act as a reservoir for fluoroquinolone resistance genes. PMID:10722479

  7. Gastrointestinal parasites of mountain gorillas (Gorilla gorilla beringei) in the Parc National des Volcans, Rwanda.

    PubMed

    Sleeman, J M; Meader, L L; Mudakikwa, A B; Foster, J W; Patton, S

    2000-09-01

    Ninety-eight fecal samples were collected from 74 free-living mountain gorillas (Gorilla gorilla beringei) from the Parc National des Volcans, Rwanda, between July 1995 and January 1997 and examined for parasites by Sheather's sugar and zinc sulfate flotation methods, trichrome staining, and larval cultures. All samples contained at least one parasite. Seventeen endoparasites were identified, including eight protozoa, seven nematodes, one cestode, and one trematode. Two species of arthropod mite were also recovered from the fecal samples. Parasites observed on fecal examinations included strongyle/trichostrongyle-type eggs (72/74) (representing Oesphagostomum sp., Trichostrongylus sp., Hyostrongylus spp., and possibly Murshidia sp.), Strongyloides sp. (1/74), Trichuris trichiura (2/74), Probstmayria sp. (7/74), Anoplocephala sp. (63/74), Entamoeba hartmanni cysts and trophozoites (19/70), Endolimax nana cysts (31/70), Iodamoeba buetschlii cysts (11/70), Endolimax nana or Iodamoeba buetschlii trophozoites (63/70). Entamoeba coli cysts and trophozoites (14/70), Entamoeba histolytica trophozoite (1/70), Chilomastix sp. cysts and trophozoites (31/70), and Giardia sp. cysts (2/70). In addition, one ascarid and one trematode egg were seen. There were no significant differences in the prevalence of parasites between males and females and between age groups: however, infants and juveniles appeared to have a lower prevalence of Anoplocephala gorillae, and the silverbacked males appeared to have a higher prevalence of Probstmayria sp. Parasite prevalence was consistent among the five social groups studied except Susa group had a significantly lower prevalence of Anoplocephala gorillae. Trichuris trichiura, Strongyloides sp., Chilomastix sp., and Endolimax nana were identified for the first time in this population, and it is possible that these parasites were of human origin. Although there were no obvious clinical effects due to the presence of these parasites, six parasites

  8. High-pressure beamline (PLANET) at the spallation neutron source, J-PARC (Invited)

    NASA Astrophysics Data System (ADS)

    Kagi, H.; Hattori, T.; Arima, H.; Utsumi, W. S.; Komatsu, K.; Nagai, T.; Yagi, T.

    2009-12-01

    Material and Life Science experimental Facility (MLF) of Japan Proton Accelerator Research Complex (J-PARC) will be one of the most powerful spallation neutron facilities in the world. The pulsed neutron source with a liquid Hg target is designed to be running at 25 Hz with a power of 1 MW. We have started the construction of the powder diffractometer dedicated to high-pressure experiments (PLANET) on BL-11. PLANET aims to study structures of hydrogen-bearing materials including dense hydrous minerals of the Earth’s deep interior, magmas and light element liquids. The instrument will realize diffraction and radiography experiments for powder and liquid/glass samples at high pressures up to 20 GPa and 2000 K using a large sized multi-anvil hydraulic press that can apply forces of ˜1500 ton. The instrument views a decoupled liquid H2 moderator with a cross section of 100 × 100 mm2. The primary and secondary fight paths are 25 m and 1.5 m, respectively. The 11.5-m-long supermirror guide with elliptical shape starts at a distance of 11.5 m from the moderator. Design of elliptical geometry is optimized by means of incorporating several different grade mirrors and linear approximation with planar guide in order to save cost for production without degradation of the intensity performance. The guide has a rectangular cross-section and consists of four walls coated with supermirror material. Sample is placed at 2 m from the guide exit. The 90° detectors will be installed at 1.5 m from the sample position. For the powder diffraction measurements using a multi-anvil press, an incident neutron beam passes through the vertical anvil gaps and irradiates the sample in the pressure medium. Diffracted neutrons go through the other anvil gaps at 90° direction. Half inch 3He linear position sensitive detectors with 600 mm length will be arranged horizontally and form these detector banks, which cover the scattering angle of 79° ≤ 2θ ≤ 101° and -35° ≤ Φ ≤ +35°. The

  9. New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible Streptococcus pneumoniae Isolates from France

    PubMed Central

    Decousser, Jean-Winoc; Methlouthi, Imen; Pina, Patrick; Collignon, Anne; Allouch, Pierre

    2006-01-01

    A real-time PCR assay with locked nucleic acid probes was developed to screen mutations at codons 79 and 83 of the Streptococcus pneumoniae parC gene. Only silent mutations were detected among 236 French invasive fluoroquinolone-susceptible strains. This test could be useful for some high-risk patients or in national surveys. PMID:16569894

  10. Amino acid substitutions in GyrA and ParC are associated with fluoroquinolone resistance in Mycoplasma bovis isolates from Japanese dairy calves.

    PubMed

    Sato, Toyotaka; Okubo, Torahiko; Usui, Masaru; Higuchi, Hidetoshi; Tamura, Yutaka

    2013-01-01

    We investigated the contribution of quinolone resistance-determining region (QRDR) mutations to fluoroquinolone (enrofloxacin, orbifloxacin and danofloxacin) susceptibility in 58 Mycoplasma bovis isolates from dairy cattle in Japan. Fluoroquinolone non-resistant isolates (fluoroquinolone-MICs≤2 μg/ml) possessed no QRDR mutations (19 isolates) or Ser83Leu in GyrA (32 isolates). Fluoroquinolone-resistant isolates (fluoroquinolone-MICs≥4 μg/ml) possessed Ser83Leu in GyrA and Ser81Pro in ParC (3 isolates) or Ser83Phe in GyrA and Ser80Ile in ParC (4 isolates). Laboratory-derived fluoroquinolone-resistant mutants selected from 2 isolates (possessing Ser83Leu in GyrA) had an amino acid substitution in ParC at the same position (Ser80Ile or Ser81Tyr) as fluoroquinolone-resistant isolates, suggesting a concurrent amino acid substitution in ParC (Ser80 or Ser81) is important in fluoroquinolone resistance in M. bovis isolates.

  11. Vacuum tube operation analysis under multi-harmonic driving and heavy beam loading effect in J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Yamamoto, M.; Nomura, M.; Shimada, T.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.; Schnase, A.

    2016-11-01

    An rf cavity in the J-PARC RCS not only covers the frequency range of a fundamental acceleration pattern but also generates multi-harmonic rf voltage because it has a broadband impedance. However, analyzing the vacuum tube operation in the case of multi-harmonics is very complicated because many variables must be solved in a self-consistent manner. We developed a method to analyze the vacuum tube operation using a well-known formula and which includes the dependence on anode current for some variables. The calculation method is verified with beam tests, and the results indicate that it is efficient under condition of multi-harmonics with a heavy beam loading effect.

  12. Mars14 Monte Carlo simulation for the shielding studies of the J-PARC 3 GeV ring.

    PubMed

    Nakao, Noriaki; Mokhov, Nikolai; Yamamoto, Kazami; Irie, Yoshiro; Drozhdin, Alexander

    2005-01-01

    MARS14 Monte Carlo simulations were performed for collimation and shielding studies of the J-PARC 3 GeV synchrotron ring. The beam line module locations in the 348.3 m ring and the curved tunnel sections were described by the 'MAD-MARS beam line builder' tool. A 400 MeV proton beam loss distribution, calculated with the STRUCT code, was used as a 4 kW source term in the collimator region, with 1 kW source terms in the injection and extraction regions at 400 MeV and 3 GeV, respectively. Deep penetration calculations were carried out with good statistics using a newly developed three-dimensional multi-layer technique. Prompt dose-rate distributions were calculated inside and outside the concrete and soil shield up to the ground level. Using the calculation results obtained thus, an effective shielding design was made.

  13. Validation of the U.S. NRC coupled code system TRITON/TRACE/PARCS with the special power excursion reactor test III (SPERT III)

    SciTech Connect

    Wang, R. C.; Xu, Y.; Downar, T.; Hudson, N.

    2012-07-01

    The Special Power Excursion Reactor Test III (SPERT III) was a series of reactivity insertion experiments conducted in the 1950's. This paper describes the validation of the U.S. NRC Coupled Code system TRITON/PARCS/TRACE to simulate reactivity insertion accidents (RIA) by using several of the SPERT III tests. The work here used the SPERT III E-core configuration tests in which the RIA was initiated by ejecting a control rod. The resulting super-prompt reactivity excursion and negative reactivity feedback produced the familiar bell shaped power increase and decrease. The energy deposition during such a power peak has important safety consequences and provides validation basis for core coupled multi-physics codes. The transients of five separate tests are used to benchmark the PARCS/TRACE coupled code. The models were thoroughly validated using the original experiment documentation. (authors)

  14. Rapid detection of gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae by denaturing high-performance liquid chromatography.

    PubMed

    Shigemura, Katsumi; Shirakawa, Toshiro; Okada, Hiroshi; Tanaka, Kazushi; Udaka, Tohru; Kamidono, Sadao; Arakawa, Soichi; Gotoh, Akinobu

    2004-12-01

    The detection of DNA sequence variation is fundamental to the identification of the genomic basis of phenotypic variability. Denaturing high-performance liquid chromatography (DHPLC) is a novel technique that is used to detect mutations in human DNA. This is the first report that this technique is used as a tool to detect mutations in genes encoding fluoroquinolone resistance in Neisseria gonorrhoeae. Eighty-one strains of N. gonorrhoeae were used in this study. Genomic DNA from each strain was subjected to PCR amplification of 225 bp in gyrA and 166 bp in parC spanning the fluoroquinolone-resistance determining regions (QRDRs). After we performed DNA sequencing of these amplicons and identification of mutations in the QRDRs, DHPLC was undertaken to investigate whether its results correlate the distinctive chromatogram with their DNA mutations pattern. The profilings detected by DHPLC completely corresponded to the results of the DNA sequencing in mutation patters in gyrA and parC genes. They resulted in the following amino acid substitutions: Ser-91Phe, Asp-95Gly, and Asp-95Asn in gyrA; and Gly-85Asp, Asp-86Asn, Ser-87Arg, and Ser-88Pro in parC, respectively. These mutations existed alone or as combinations, and we identified five mutations patterns in gyrA and six in parC including wild-type. These mutations and their patterns could be rapidly and reproducibly identified from the PCR products using DHPLC, producing specific peak patterns that correlate with genotypes. This novel detection system facilitates the detection of resistance alleles, providing a rapid (5 min per sample), economic (96 sample per run), and reliable technique for characterizing fluoroquinolone resistance in N. gonorrhoeae. PMID:15488283

  15. Insertion sequence disruption of adeR and ciprofloxacin resistance caused by efflux pumps and gyrA and parC mutations in Acinetobacter baumannii.

    PubMed

    Lopes, B S; Amyes, S G B

    2013-02-01

    Acinetobacter baumannii is a pathogenic bacterium responsible for a wide range of infections in immunocompromised patients. This study examined the role of insertional inactivation of the adeR gene and its effect on adeABC gene expression along with characterisation of the gyrA and parC mutations involved in ciprofloxacin resistance in three A. baumannii clinical isolates and their derivatives. Primers designed for the detection of adeSRABC detected the presence of ISAba16, which disrupted the adeR gene in strain Ab12M, and ISAba1, which disrupted the same gene in strains Ab18 and Ab209. A second copy of ISAba1 was detected upstream of the adeA gene in Ab209 leading to AdeABC pump expression. AdeIJK pump expression was seen in all of the isolates but was not as significant as AdeABC expression. Minimum inhibitory concentrations of ciprofloxacin were ≥256 mg/L for all of the isolates and a decrease of ≥8-fold was seen following addition of the efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine. Fluorometric analysis also demonstrated active efflux, with upregulation of adeIJK and some genes of the adeABC operon in some strains. Sequencing of the quinolone resistance-determining region of the gyrA and parC genes revealed a Ser83→Leu change in the gyrA gene and a novel change of Ser80→Trp in the parC gene of Ab12, Ab12M and Ab209; in Ab18 there was a Ser80→Leu change in parC. This study shows the multifactorial contribution of different mechanisms in A. baumannii leading to ciprofloxacin resistance. PMID:23217848

  16. EPA/IFP (Environmental Protection Agency/Institute Francais Du Petrole) European workshop on the emission of nitrous oxide from fossil-fuel combustion: Rueil-Malmaison, France, June 1-2, 1988

    SciTech Connect

    Ryan, J.V.; Srivastava, R.K.

    1989-10-01

    This report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil-fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increasing atmospheric N2O concentrations have been linked to depletion of stratospheric ozone (O3) and to global-climate warming. The combustion of fossil fuels has been identified as a potential major anthropogenic source of N2O. The workshop had two goals: (1) to exchange information among various international research and industrial groups that are involved in N2O chemistry, modeling, and measurement; and (2) to develop a network for coordinating future related efforts.

  17. Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland.

    PubMed

    Onizawa, Katsuhiro; Muramatsu, Takashi; Matsuki, Miwako; Ohta, Kazumasa; Matsuzaka, Kenichi; Oda, Yutaka; Shimono, Masaki

    2009-03-01

    We investigated cell response, including cell proliferation and expression of heat stress protein and bcl-2, to clarify the influence of low-level [gallium-aluminum-arsenide (Ga-Al-As) diode] laser irradiation on Par-C10 cells derived from the acinar cells of rat parotid glands. Furthermore, we also investigated amylase release and cell death from irradiation in acinar cells from rat parotid glands. The number of Par-C10 cells in the laser-irradiated groups was higher than that in the non-irradiated group at days 5 and 7, and the difference was statistically significant (P < 0.01). Greater expression of heat shock protein (HSP)25 and bcl-2 was seen on days 1 and 3 in the irradiated group. Assay of the released amylase showed no significant difference statistically between the irradiated group and the non-irradiated group. Trypan blue exclusion assay revealed that there was no difference in the ratio of dead to live cells between the irradiated and the non-irradiated groups. These results suggest that low-level laser irradiation promotes cell proliferation and expression of anti-apoptosis proteins in Par-C10 cells, but it does not significantly affect amylase secretion and does not induce rapid cell death in isolated acinar cells from rat parotid glands.

  18. Resistance Mutations in gyrA and parC are Common in Escherichia Communities of both Fluoroquinolone-Polluted and Uncontaminated Aquatic Environments

    PubMed Central

    Johnning, Anna; Kristiansson, Erik; Fick, Jerker; Weijdegård, Birgitta; Larsson, D. G. Joakim

    2015-01-01

    Alterations in the target proteins of fluoroquinolones, especially in GyrA and ParC, are known to cause resistance. Here, we investigated environmental Escherichia communities to explore the possible link between the abundance of mutations, and the exposure to fluoroquinolones. Sediment samples were collected from a relatively pristine lake, up and downstream from a sewage treatment plant, and from several industrially polluted sites. The quinolone resistance-determining regions of gyrA and parC were analyzed using amplicon sequencing of metagenomic DNA. Five non-synonymous substitutions were present in all samples, and all of these mutations have been previously linked to fluoroquinolone resistance in Escherichia coli. In GyrA, substitutions S83L and D87N were on average detected at frequencies of 86 and 32%, respectively, and 31% of all amplicons encoded both substitutions. In ParC, substitutions S80I, E84G, and E84V were detected in 42, 0.9, and 6.0% of the amplicons, respectively, and 6.5% encoded double substitutions. There was no significant correlation between the level of fluoroquinolone pollution and the relative abundance of resistance mutations, with the exception of the most polluted site, which showed the highest abundance of said substitutions in both genes. Our results demonstrate that resistance mutations can be common in environmental Escherichia, even in the absence of a fluoroquinolone selective pressure. PMID:26696975

  19. Performance of a superconducting magnet system operated in the Super Omega Muon beam line at J-PARC

    SciTech Connect

    Makida, Yasuhiro; Ikedo, Yutaka; Ogitsu, Toru; Shimomura, Koichiro; Miyake, Yasuhiro; Yoshida, Makoto; Adachi, Taihei; Kadono, Ryosuke; Kawamura, Naritoshi; Strasser, Patric; Koda, Akihiro; Fujimori, Hiroshi; Nishiyama, Kusuo; Ohhata, Hirokatsu; Okamura, Takahiro; Okada, Ryutaro; Orikasa, Tomofumi

    2014-01-29

    A superconducting magnet system, which is composed of an 8 m long solenoid for transportation and 12 short solenoids for focusing, has been developed for Muon Science Establishment facility of J-PARC. The transport solenoid is composed of a 6 m straight section connected to a 45 degree curved section at each end. Muons of various momenta and of both electric charges are transported through the solenoid inner bore with an effective diameter of 0.3 m, where 2 T magnetic field is induced. There are 12 focusing solenoids with an effective bore diameter of 0.6 m and a length of 0.35 m arranged on a straight line at suitable intervals. The maximum central field of each focusing solenoid is 0.66 T. All solenoid coils are cooled by GM cryocoolers through their own conductions. The magnet system has been installed into the beam line in the summer of 2012, and its performance has been checked. Beam commissioning has been carried out since October 2012. During beam operation, temperature rise over 6 K in the transport solenoid due to a nuclear heating from the muon production target is observed at beam intensity of about 300 kW.

  20. Pressure Rise Analysis When Hydrogen Leak from a Cracked Pipe in the Cryogenic Hydrogen System in J-PARC

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Aso, T.; Hasegawa, S.; Ushijima, I.; Kato, T.; Ohtsu, K.; Ikeda, Y.

    2006-04-01

    As one of the main experimental facilities in the Japan Proton Accelerator Research Complex (J-PARC), an intense spallation neutron source (JSNS) driven by a 1 MW proton beam is being constructed. Cryogenic hydrogen at supercritical pressure is selected as a moderator. The total nuclear heating at the moderators is estimated to be a 3.7 kW. A hydrogen system to cool the moderators has been designed. The most severe off-normal event for the cryogenic hydrogen system is considered to be a hydrogen leak when a pipe cracks. In such a case, the hydrogen must be discharged to atmosphere quickly and safely. An analytical code that simulates the pressure change during a hydrogen leak was developed. A pressure rise analysis for various sized cracks was performed, and the required sizes for relief devices were determined. A safety valve size is φ42.7 mm and a rupture disc for vacuum layer should have a diameter of 37.1 mm, respectively.

  1. Pressure Rise Analysis When Hydrogen Leak from a Cracked Pipe in the Cryogenic Hydrogen System in J-PARC

    SciTech Connect

    Tatsumoto, H.; Aso, T.; Hasegawa, S.; Ushijima, I.; Kato, T.; Ohtsu, K.; Ikeda, Y.

    2006-04-27

    As one of the main experimental facilities in the Japan Proton Accelerator Research Complex (J-PARC), an intense spallation neutron source (JSNS) driven by a 1 MW proton beam is being constructed. Cryogenic hydrogen at supercritical pressure is selected as a moderator. The total nuclear heating at the moderators is estimated to be a 3.7 kW. A hydrogen system to cool the moderators has been designed. The most severe off-normal event for the cryogenic hydrogen system is considered to be a hydrogen leak when a pipe cracks. In such a case, the hydrogen must be discharged to atmosphere quickly and safely. An analytical code that simulates the pressure change during a hydrogen leak was developed. A pressure rise analysis for various sized cracks was performed, and the required sizes for relief devices were determined. A safety valve size is {phi}42.7 mm and a rupture disc for vacuum layer should have a diameter of 37.1 mm, respectively.

  2. The Hippoboscidae (Insecta: Diptera) from Madagascar, with new records from the “Parc National de Midongy Befotaka”

    PubMed Central

    Rahola, N.; Goodman, S.M.; Robert, V.

    2011-01-01

    The Hippoboscidae or “louse-flies” is a family of pupiparous Diptera, which in their adult stage are ectoparasites of mammals and birds. This paper presents a comprehensive review of Malagasy Hippoboscidae. In total, amongst the 213 species of this family known worldwide, 14 have been reported in Madagascar, among which six are considered as endemic to the Malagasy region. In addition, data are presented from a collection of 17 Hippoboscidae obtained from seven species of forest-dwelling birds in the “Parc National de Midongy Befotaka”, southeastern Madagascar, in 2003. The flies in this collection belong to three different species: Icosta malagasii (one), Ornithoica podicipis (ten) and Ornithoctona laticornis (six). The two former species were previously only known from single specimens in museum collections; the later species is distributed across much of the Afrotropical region and the records presented herein are the first for Madagascar. All the seven bird species are new hosts for hippoboscids. We present the first description of the male of Icosta malagasii. An illustrated dichotomous determination key of the 14 Malagasy species, based on morphological criteria only, is presented. PMID:21678788

  3. Analysis of the Peach Bottom Turbine Trip 2 Experiment by Coupled RELAP5-PARCS Three-Dimensional Codes

    SciTech Connect

    Bousbia-Salah, Anis; Vedovi, Juswald; D'Auria, Francesco; Ivanov, Kostadin; Galassi, Giorgio

    2004-10-15

    Thanks to continuous progress in computer technology, it is now possible to perform best-estimate simulations of complex scenarios in nuclear power plants. This method is carried out through the coupling of three-dimensional (3-D) neutron modeling of a reactor core into system codes. It is particularly appropriate for transients that involve strong interactions between core neutronics and reactor loop thermal hydraulics. For this purpose, the Peach Bottom boiling water reactor turbine trip test was selected to challenge the capability of such coupled codes. The test is characterized by a power excursion induced by rapid core pressurization and a self-limiting course behavior. In order to perform the closest simulation, the coupled thermal-hydraulic system code RELAP5 and 3-D neutron kinetic code PARCS were used. The obtained results are compared to those available from experimental data. Overall, the coupled code calculations globally predict the most significant observed aspects of the transient, such as the pressure wave amplitude across the core and the power course, with an acceptable agreement. However, sensitivity studies revealed that more-accurate code models should be considered in order to better match the void dynamic and the cross-section variations during transient conditions.

  4. Maintenance and operation procedure, and feedback controls of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The maintenance and operation procedure to minimize the plasma chamber (PCH) replacement time on the beam line, which is very important to maximize the J-PARC beam time especially for an antenna failure, is presented in this paper. The PCH preserved by filling argon (Ar) gas inside after pre-conditioning including pre-cesiation to produce the required beam at a test-stand successfully produced the required beam on the beam line with slight addition of cesium (Cs). The methods of the feedback controls of a 2MHz-RF-matching, an H{sup −} ion beam intensity and the addition of Cs are also presented. The RF-matching feedback by using two vacuum variable capacitors (VVCs) and RF-frequency shift produced the almost perfect matching with negligibly small reflected RF-power. The H{sup −} ion beam intensity was controlled within errors of ±0.1mA by the RF-power feedback. The amount of Cs was also controlled by remotely opening a Cs-valve to keep the RF-power lower than a settled value.

  5. GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital

    PubMed Central

    Gopal, Muthu; Elumalai, Sathishkumar; Arumugam, Suresh; Durairajpandian, Vishnuprabu; Kannan, Munirajan Arasambattu; Selvam, Esthermary

    2016-01-01

    Introduction Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the therapeutic failure of fluoroquinolones in patients with Salmonella infection. Resistance to quinolones/ fluoroquinolones commonly arises due to target site mutation. Aim The present study was planned to analyze mutation in Quinolone Resistance Determining Region (QRDR) of quinolone resistant Salmonella isolates. Materials and Methods A total of 133 S. Typhi isolates (blood (n = 131), stool (n=1) and bone marrow aspirate (n=1)) from tertiary care hospitals in Chennai and Puducherry, were included in this study. Minimum Inhibitory Concentrations (MIC) were carried out according to the Clinical Laboratory Standard Institute (CLSI)guidelines 2014. Mutations in gyrA and parC genes were analyzed by PCR-RFLP (Restriction Fragment Length Polymorphism) method followed by DNA sequencing. Results Of the 133 S. Typhi, 99.2% were resistant to nalidixic acid and 21% were resistant to ciprofloxacin by MIC method. 94% of isolates showed Ser 83 mutation in gyrA and 21.8% of isolates showed Trp106-Gly mutation in parC. Conclusion Mutations in gyrA and parC genes are highly prevalent among Salmonella species. Irrational use of fluoroquinolones may increase the accumulation of mutations in the DNA gyrase and topoisomerase encoding genes, which lead to the emergence of high level fluoroquinolone-resistant Salmonella strains in future. PMID:27630841

  6. gyrA and parC mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa from Nini Hospital in north Lebanon.

    PubMed

    Salma, Rayan; Dabboussi, Fouad; Kassaa, Imad; Khudary, Rami; Hamze, Monzer

    2013-02-01

    The problem of Pseudomonas aeruginosa resistance to fluoroquinolones is of growing concern in hospitals. The major mechanism of the resistance of this bacterium to fluoroquinolones is the modification of type II topoisomerases (DNA gyrase and topoisomerase IV). In this study, we examined, using the technique of DNA pyrosequencing, mutations in the quinolone resistance-determining regions of the gyrA and parC genes of 38 clinical isolates of P. aeruginosa that were non-susceptible to at least one of the three fluoroquinolones tested. The most common origin of the isolates was sputum (44.7 %), followed by wounds (11 %), urine (5 %), and ear discharge (5 %). Serotypes O:11 (21 %), O:2 (18.4 %), and O:6 (7.8 %), were the most predominant. Among these 38 isolates, 11 were susceptible, 22 were resistant, and 5 were intermediate-resistant to ciprofloxacin. We found that 19 (50 %) of these strains had a mutation in the gyrA gene (Thr 83 Ile), one of them presented a new mutation (His 80 Arg), 8 (21.05 %) strains had an additional mutation in the parC gene (Ser 80 Leu), and one of these strains had two new mutations not previously reported (Gln 84 Asp, Ala 85 Gly). The ciprofloxacin-sensitive strains had no mutations in the sequence area examined. We found that 81.8 % of the isolates that were resistant to ciprofloxacin had a mutation in the gyrA gene. Some of these resistant strains also had a mutation in the parC gene. The results of this study suggest that pyrosequencing is a reliable technique for the determination of the antibiotic resistance pattern of a given bacterial strain. PMID:22821356

  7. The St-Louis du Parc Heart Health Project: a critical analysis of the reverse effects on smoking

    PubMed Central

    Renaud, L; O'Loughlin, J; Dery, V

    2003-01-01

    Objectives: Although some school based smoking prevention programmes have shown positive impacts, others have had only short term effects, no effects, and in some cases reverse effects. The St-Louis du Parc Heart Health Project was a five year heart health promotion programme targeting children in eight elementary schools aged 9–12 years in disadvantaged multiethnic neighbourhoods in Montreal. In a controlled, longitudinal evaluation, the programme produced reverse effects on smoking—children exposed to the programme were more likely to initiate and to continue smoking than control children. This article explores hypotheses to explain the reverse effects. Design: Following work by an in-house committee, a consensus workshop with international experts was conducted to develop hypotheses to explain the reverse effects. This was complemented by an analysis of the programme's concordance with the standard guidelines on the school based prevention of tobacco use, and discussions with experts at the Centers for Disease Control and Prevention. Results: The programme respected most standard guidelines for smoking prevention programmes with respect to content and mode of delivery. Hypotheses to explain the reverse effects include: an unfavourable environment characterised by strong pro-smoking models and resistance to environmental interventions; heightened sensitivity to smoking among children most exposed to the programme; defence mechanisms among children stimulated by cognitive dissonance or anxiety; unanticipated effects associated with the health educator who delivered the programme; inadequate attention in programme development to the diverse cultural origins of the population targeted; and intervention content inappropriately targeted to children's stages of cognitive development. Conclusion: Elementary school based interventions should aim to develop a clear and coherent social norm about the non-use of tobacco, as a precursor to or in close conjunction with

  8. A novel time-spatial-focusing momentum-correction analyzer for the near-backscattering spectrometer DIANA at J-PARC

    NASA Astrophysics Data System (ADS)

    Takahashi, Nobuaki; Shibata, Kaoru; Sato, Taku J.; Arai, Masatoshi; Mezei, Ferenc

    2008-03-01

    We have developed a novel configuration concept of crystal chips for time-of-flight (TOF) crystal-analyzer neutron inelastic scattering spectrometers, which simultaneously achieve time-focusing, spatial-focusing and momentum-correcting abilities. This concept will be adopted for the planned TOF near-backscattering spectrometer, DIANA which has been proposed for construction at the Japan Proton Accelerator Research Complex (J-PARC). We will first discuss the new analyzer layout method satisfying both time- and spatial-focusing and momentum-correction concepts and then the focusing performances as evaluated by Monte-Carlo simulations and compared to the generally used energy-focusing analyzer configuration.

  9. Apprenez la Science en Francais?

    ERIC Educational Resources Information Center

    Edmonds, Juliet; Jacobs, Pippa

    2011-01-01

    The authors explain why integrating the teaching of science and French is not as ridiculous as it may at first sound. They describe how this innovative integrated approach works in a primary school in Oxfordshire. The project involves Content and Language Integrated Learning (CLIL). CLIL is a method whereby a curriculum subject is planned and…

  10. Rare Kaon Decays, KEK experiment E391 and E14 at the Japan Physics and Accelerator Research Complex (J-PARC)

    SciTech Connect

    Wah, Yau Wai

    2012-12-06

    The goal of the J-PARC neutral kaon experiment (E14/KOTO) is to discover and measure the rate of the kaon rare decay to pi-zero and two neutrinos. This flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement (or depletion) to the branching ratio which in the Standard Model is accurately predicted within a few percent to be 2.8x10-11. The experiment is designed to observe more than 100 events at the Standard Model branching. It is a follow-up of the KEK E391a experiment and has stage-2 approval by J-PARC PAC in 2007. E14/KOTO has collaborators from Japan (Kyoto, Osaka, Yamagata, Saga), US (Arizona State, Chicago, Michigan Ann Arbor), Taiwan (National Taiwan), Korea, and Russia (Dubna). The experiment exploits the 300kW 30-50 GeV proton delivery of the J-PARC accelerator with a hermetic high acceptance detector with a fine grained Cesium Iodide (CsI) crystal calorimeter, and state of the art electronic front end and data acquisition system. With the recovery of the tsunami disaster on March 11th 2011, E14 is scheduled to start collecting data in December 2012. During the detector construction phase, Chicago focuses on the front end electronics readout of the entire detector system, particularly the CsI calorimeter. The CsI crystals together with its photomultipliers were previously used at the Fermilab KTeV experiment (E832/E799), and were loaned to E14 via this Chicago DOE support. The new readout electronics includes an innovative 10-pole pulse-shaping technique coupled with high speed digitization (14-bit 125MHz and 12-bit 500MHz). This new instrument enables us to measure both energy and timing, particularly with timing resolution better than 100 psec. Besides the cost saving by elimination of the standard time to digital converters, it is now possible to measure the momenta of the final state photons for additional background suppression

  11. Analysis of a rod withdrawal in a PWR core with the neutronic- thermalhydraulic coupled code RELAP/PARCS and RELAP/VALKIN

    SciTech Connect

    Miro, R.; Maggini, F.; Barrachina, T.; Verdu, G.; Gomez, A.; Ortego, A.; Murillo, J. C.

    2006-07-01

    The Reactor Ejection Accident (REA) belongs to the Reactor Initiated Accidents (RIA) category of accidents and it is part of the licensing basis accident analyses required for pressure water reactors (PWR). The REA at hot zero power (HZP) is characterized by a single rod ejection from a core position with a very low power level. The evolution consists basically of a continuous reactivity insertion. The main feature limiting the consequences of the accident in a PWR is the Doppler Effect. To check the performance of the coupled code RELAP5/PARCS2.5 and RELAP5/VALKIN a REA in Trillo NPP is simulated. These analyses will allow knowing more accurately the PWR real plant phenomenology in the RIA most limiting conditions. (authors)

  12. Beam Commissioning Results of the J-PARC 3-GeV RCS Injection System with Upgraded 400 MeV Beam

    NASA Astrophysics Data System (ADS)

    Saha, P. K.

    In order to achieve 1 MW beam power, injection system of the 3-GeV Rapid Cycling Synchrotron (RCS) of Japan Proton Accelerator Research Complex (J-PARC) was upgraded to the design injection energy of 400 MeV in the 2013 from that of 181 MeV. The higher injection energy plays a key role to mitigate the space charge effect at lower energy region so as to realize 1 MW beam. The beam commissioning with newly installed and upgraded components was successful to demonstrate a more than 550 kW beam power in the RCS with sufficiently low beam loss. This is a milestone towards realizing 1 MW, which is scheduled in October 2014. A detail of the design criteria along with 1st stage beam commissioning results are presented.

  13. Are low altitude alpine tundra ecosystems under threat? A case study from the Parc National de la Gaspésie, Québec

    NASA Astrophysics Data System (ADS)

    Dumais, Catherine; Ropars, Pascale; Denis, Marie-Pier; Dufour-Tremblay, Geneviève; Boudreau, Stéphane

    2014-09-01

    According to the 2007 IPCC report, the alpine tundra ecosystems found on low mountains of the northern hemisphere are amongst the most threatened by climate change. A treeline advance or a significant erect shrub expansion could result in increased competition for the arctic-alpine species usually found on mountaintops and eventually lead to their local extinction. The objectives of our study were to identify recent changes in the cover and growth of erect woody vegetation in the alpine tundra of Mont de la Passe, in the Parc National de la Gaspésie (Québec, Canada). The comparison of two orthorectified aerial photos revealed no significant shift of the treeline between 1975 and 2004. During the same period however, shrub species cover increased from 20.2% to 30.4% in the lower alpine zone. Dendrochronological analyses conducted on Betula glandulosa Michx. sampled at three different positions along an altitudinal gradient (low, intermediate and high alpine zone) revealed that the climatic determinants of B. glandulosa radial growth become more complex with increasing altitude. In the lower alpine zone, B. glandulosa radial growth is only significantly associated positively to July temperature. In the intermediate alpine zone, radial growth is associated positively to July temperature but negatively to March temperature. In the high alpine zone, radial growth is positively associated to January, July and August temperature but negatively to March temperature. The positive association between summer temperatures and radial growth suggests that B. glandulosa could potentially benefit from warmer temperatures, a phenomenon that could lead to an increase in its cover over the next few decades. Although alpine tundra vegetation is not threatened in the short-term in the Parc National de la Gaspésie, erect shrub cover, especially B. glandulosa, could likely increase in the near future, threatening the local arctic-alpine flora.

  14. Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene.

    PubMed

    Le Carrou, J; Laurentie, M; Kobisch, M; Gautier-Bouchardon, A V

    2006-06-01

    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser80-->Phe and Asp84-->Asn), and one point mutation was observed just behind the QRDR of ParC (Ala116-->Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC.

  15. Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.

    PubMed

    Al-Marzooq, Farah; Mohd Yusof, Mohd Yasim; Tay, Sun Tee

    2014-01-01

    Ninety-three Malaysian extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6')-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4- ≥ 32  μ g/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6')-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2  μ g/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6')-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital.

  16. In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

    PubMed

    Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

    2015-04-01

    Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. PMID:25645833

  17. The containment of toxic wastes: I. Long term metal movement in soils over a covered metalliferous waste heap at Parc lead-zinc mine, North Wales.

    PubMed

    Shu, J; Bradshaw, A D

    1995-01-01

    In order to stabilise and contain a toxic metalliferous waste heap at Parc Mine, North Wales, it was covered with 30-40 cm layer of quarry waste in 1977-1978, and sown with a grass/clover seed mixture. This study has examined subsequent metal movement in the cover material and its effect on vegetation. The results, especially when compared with previous observations, give no evidence of upward migration of metals by capillarity in the cover material. Sideways movement of leachate, however, appears to be carrying the metals into the cover material on the sloping sides, giving rise to increasing concentrations of heavy metals in the vegetation and dieback in some places. Root growth on the flat top of the heap is greater than on the slope, but the roots have not penetrated the waste and the contents of Pb, Zn and Cd in surface vegetation remain low. Surface covering of toxic waste with coarse materials restricting capillary rise is therefore a valid reclamation technique so long as lateral movement of toxic leachate can be controlled.

  18. Numerical study for beam loss occurring for wide-ranging transverse injection painting and its mitigation scenario in the J-PARC 3-GeV RCS

    NASA Astrophysics Data System (ADS)

    Hotchi, Hideaki; Tani, Norio; Watanabe, Yasuhiro

    2015-04-01

    In the J-PARC 3-GeV Rapid Cycling Synchrotron (RCS), transverse injection painting is utilized to manipulate the transverse beam profile according to the requirements from the downstream facilities as well as to mitigate the space-charge induced beam loss in RCS. Therefore, a flexible control is required for the transverse painting area. But now the available range of transverse painting is limited to small area due to beta function beating caused by the edge focus of injection bump magnets which operate during the beam injection period. This beta function beating additionally excites various random betatron resonances through a distortion of the lattice super-periodicity, causing a shrinkage of the dynamic aperture during the injection period. This decrease of the dynamic aperture leads to extra beam loss at present when applying large transverse painting. For beta function beating caused by the edge focus, we proposed a correction scheme with additional pulse-type quadrupole correctors. In this paper, we will discuss the feasibility and effectiveness of this correction scheme for expanding the transverse injection painting area with no extra beam loss, while considering the beam loss and its mitigation mechanisms, based on numerical simulations.

  19. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Koizumi, I.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2014-02-15

    The prototype rf-driven H{sup −} ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H{sup −} ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (T{sub PE}) of about 120 °C compared with the typically used T{sub PE} of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H{sup −} ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  20. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H(-) ion source.

    PubMed

    Ueno, A; Koizumi, I; Ohkoshi, K; Ikegami, K; Takagi, A; Yamazaki, S; Oguri, H

    2014-02-01

    The prototype rf-driven H(-) ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H(-) ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (TPE) of about 120 °C compared with the typically used TPE of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H(-) ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  1. First 2 years of Atmospheric CO2 measurements in the Estany Llong plain (2100 masl, Parc Nacional d'Aigüestortes i Estany de Sant Maurici, Pyrenees, Catalonia, Spain).

    NASA Astrophysics Data System (ADS)

    Curcoll, Roger; Recolons, Montserrat; Font, Anna; Agraz, Laura; Parga, Elena; Bacardit, Montse; Camarero, Lluís.; Pueyo, Salva; Rodó, Xavier; Morguí, Josep Anton

    2010-05-01

    Since April 2009, air samples are being taken bi-weekly at 10 GMT in the plain of the Estany Llong at 2100 masl. Estany Llong air sampling site (ELL, 42°34'29''N 0°57'17''E) is a remote site situated in the SW principal valley of the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. New Flask-sampling equipment for Remote Mountain Sites was developed by the Institut Català de Ciències del Clima (IC3) to allow flask sampling in extreme weather conditions and carrying the sampling equipment for more than 10 km without damaging flasks. Dry Air analysis for CO2 are done at the Laboratory of IC3 using two coupled modified IRGA Licor-7000, where both pressure and flow are externally controlled. Far away from populated areas, ELL site acts as a remote site, but it is also responding to discrete events as snow melting, summer cattle breeding on pastures and trekking frequentation. Series of CO2 obtained are included as part of Long Term Ecological Research (LTER) at the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. In the long term, these measurements show the mountain ecosystems contribution and geomorphologic influence on the CO2 budget of the air masses crossing a mountain range.

  2. Le Francais quand meme (French Nonetheless).

    ERIC Educational Resources Information Center

    Delautier, Jean-Marie

    1983-01-01

    Political, attitudinal, and administrative problems of teaching compulsory foreign languages in Colombia are described and discussed from the point of view of a French teacher in a system characterized by confusion and lack of student interest. (MSE)

  3. Le Francais Courant (Contemporary French), Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course has been developed basically within the limits of Units 4-6 of "A-LM French: Level 1", second edition. The primary objectives are to develop French vocabulary relative to the family, home, transportation, and foods by continuing to work with short dialogues based on everyday, teenage experiences. While reviewing previously studied…

  4. Etude Differentielle Intonative Francais/Anglais.

    ERIC Educational Resources Information Center

    Lepetit, D.; Martin, Ph.

    1990-01-01

    Describes an investigation of the differences and similarities existing between the intonation systems of French and English. The unity of the procedures described here is confirmed by an analysis of intonational errors made by English-speaking learners of French. (Author/VWL)

  5. Les affaires "en francais" (Business "In French").

    ERIC Educational Resources Information Center

    Sanko, Helene N.

    1993-01-01

    A French brochure entitled "700 Current Words for Business" was developed to familiarize the business community with modern French business vocabulary and avoid intrusion of terminology from other languages. Some terms are neologisms. Translations from Latin, Japanese, and English illustrate the etymology and morphological patterns of some idioms…

  6. French: An Accommodating Language? = Le Francais: Langue D'Accueil?

    ERIC Educational Resources Information Center

    Wright, Sue, Ed.

    This bilingual book considers recent developments in French attitudes towards language purism, borrowing, and the incursion of English. The book begins with an essay by French sociolinguist Henriette Walter, and most of the following essays are direct responses to her ideas. All chapters are provided in French and English. Chapter titles include…

  7. Roumanie: Le Francais d'abord (Romania: French First).

    ERIC Educational Resources Information Center

    Serren-Rosso, M. L.

    1993-01-01

    Eighty percent of the schools in Iasi, Moldova's capital city, teach French as a second language. The city's French Cultural Center is a focus for educational and cultural information and organization. The center helped upgrade the professional level of teaching following the demise of communism in Eastern Europe. (CNP)

  8. Morphologie et syntaxe du francais (French Morphology and Syntax)

    ERIC Educational Resources Information Center

    Sourdot, Marc

    1977-01-01

    A study of the relationship of morphology and syntax to the communication process from the functionalist viewpoint. Topics considered are: morphological processes, that is the distinction between functional and contingent language facts; the degree of necessity of syntax; the difference between functionalism and traditional grammar. (Text is in…

  9. Les francais de traduction (Different Ways to Translate French Texts).

    ERIC Educational Resources Information Center

    Renaud, Gaston R.

    1986-01-01

    Reviews the variety of language styles with which the translator deals and discusses the esthetic and practical advantages of adapting the language of a text to the sociocultural and communicative habits of a specific linguistic group. (MSE)

  10. Un cours avance de francais: Le francais tel qu'on le parle (An Advanced Course in French: Colloquial French)

    ERIC Educational Resources Information Center

    Creusot, Andre

    1971-01-01

    Second of three articles on an advanced French program sponsored by the Language Department of the State University of Mons, Belgium. Emphasis is on the phonology, lexicology, and syntax of spoken French. (DS)

  11. En Francais dans le texte: etude des emprunts francais en anglo-americain (In French in the Text: Study of French Borrowing in Anglo-American).

    ERIC Educational Resources Information Center

    Otman, Gabriel

    1989-01-01

    Analysis of the linguistic borrowing from French of American newspapers looks at the areas where vocabulary is borrowed and stereotypes are perpetuated. The alterations made in French expressions, as a result of ignorance or in order to suit American habits, are examined. (MSE)

  12. Modeles de rendement langagier: Francais, 12e annee. Francais langue premiere (Models of Linguistic Production: French, 12th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for twelfth grade…

  13. L'Onomatopee dans la classe de francais (Onomatopoeia in the French Class).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1988-01-01

    Onomatopoeia is overlooked in many French grammar courses but plays a key role in everyday speech. Classification according to the feelings communicated stresses their importance. Students enjoy learning the sounds produced by animals in a second language and discovering the abundance of onomatopoeia in songs, commercials, comic books, and slang.…

  14. Le Francais parle. Etudes sociolinguistiques (Spoken French. Sociolinguistic Studies). Current Inquiry into Languages and Linguistics 30.

    ERIC Educational Resources Information Center

    Thibault, Pierrette

    This volume contains twelve articles dealing with the French language as spoken in Quebec. The following topics are addressed: (1) language change and variation; (2) coordinating expressions in the French spoken in Montreal; (3) expressive language as source of language change; (4) the role of correction in conversation; (5) social change and…

  15. Le francais fonde sur la competence, Avance (Competency Based French, Advanced).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. It includes 26 topical lessons at the advanced level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues or texts. Lesson topics include: orienting oneself; discussing…

  16. Jouer au football... et apprendre le francais (Playing Football...and Learning French).

    ERIC Educational Resources Information Center

    Gutierrez, Alma Rosa Aguilar; Duarte, Delma Victoria Gonzalez

    1992-01-01

    Two teachers in Costa Rica have adopted a thematic approach to French second-language teaching that uses instructional materials about soccer from the French popular press and television, and related class activities, to motivate their students, for whom soccer is culturally important. (MSE)

  17. Informatique et francais langue etrangere (Information Science and French as a Foreign Language).

    ERIC Educational Resources Information Center

    Abry, Dominique; Scholl, Maryse

    1984-01-01

    An interdisciplinary experiment to develop materials for computer-assisted French instruction at the University of Grenoble is described and the process of translating objectives and strategies into exercises relying on student-machine interaction is chronicled. Three approaches were used: student response using stated rules, recognition…

  18. Des citoyens francais a quatre pattes (Four-footed French Citizens).

    ERIC Educational Resources Information Center

    Champ-Renaud, Dominique

    1983-01-01

    A class activity is described involving a panel discussion of the role of dogs in French culture and related issues of public administration such as animal protection laws. Panel members' roles (public officials, veterinarians, etc.), audience roles (dog owner, father of a bitten child, etc.), and followup activities are outlined. (MSE)

  19. Uruguay: Le francais en quete d'image (Uruguay: French in Search of an Image).

    ERIC Educational Resources Information Center

    Francais dans le Monde, 1993

    1993-01-01

    The role of French language instruction in Uruguay is assessed. Drawing on results of recent surveys, it is observed that French suffers from a lackluster image, and from a lack of confidence among language teachers themselves. (MSE)

  20. L'Enseignement du Francais au Moyen de L'Action (Teaching French through Action).

    ERIC Educational Resources Information Center

    Segal, Bertha

    A teaching guide containing 102 elementary to intermediate level French lessons is presented. The lessons are based on the Total Physical Response technique of second language instruction. They follow the stages of first language acquisition: listening, speaking, and reading. Each of the ten units contains a list of vocabulary words, individual…

  1. L'Economie Francais. Units in Economics for French Classes. Intermediate Level.

    ERIC Educational Resources Information Center

    Jennings, Carol; And Others

    Four units on the French economy, designed for classroom use at the intermediate level, are related in their educational objectives: to shed light on French culture and strengthen second language skills. Each unit describes its specific objectives, materials, texts, instructional procedures, and student evaluation methods. Sample tests and…

  2. Technoscientific French Teaching Guide = Guide pour l'enseignement du Francais technoscientifique.

    ERIC Educational Resources Information Center

    Muller, Brigitte D.

    This course guide aids university professors in doing research to develop a course in scientific and technical French. The course is intended to aid students in developing communicative skills in French in the context of science and technology. The course introduces students to the culture of France as well as to its industrial and technological…

  3. Le Francais, Langue Seconde: Aspects de la Conversation (French as a Second Language: Conversational Aspects).

    ERIC Educational Resources Information Center

    Germain, Claude

    The nature of conversation as communication is explored in its psychological, linguistic, and didactic aspects with particular reference to the learning of French as a second language. Major emphasis is placed on psychological and linguistic theories. In the didactic section, the problems, value, and methodology of conversation classes are…

  4. Le francais fonde sur la competence, Novice (Competency Based French, Novice).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. The guide includes 21 topical lessons at the introductory level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues. Lesson topics include: greetings; introducing…

  5. L'enseignement du francais au Quebec (The Teaching of French in Quebec)

    ERIC Educational Resources Information Center

    Mear-Crine, A. M.

    1977-01-01

    This article reviews the situation of the instruction of French in Quebec, in terms of the role of French and attitudes toward standard and non-standard varieties of French, the acquisition of French by native French speakers. Bidialectal instruction is suggested as one way of dealing with non-standard varieties. (Text is in French.) (CLK)

  6. Enseigner quel francais du tourisme (Which French to Teach for Tourism).

    ERIC Educational Resources Information Center

    Larsson, Bjorn

    1992-01-01

    Development of a course in French for tourism and the hotel industry in Sweden is chronicled, focusing on the process of functional analysis used to determine appropriate language content. A general functional outline of touristic French and an outline of language functions specific to a restaurant situation are presented. (MSE)

  7. Elements de correction phonetique du francais (Elements of Phonetic Correction of French). Publication B-53.

    ERIC Educational Resources Information Center

    LeBel, Jean-Guy

    Three essays are presented that deal with phonetic correction and that are intended specifically for Anglophones. They deal with the following topics: (1) methods and processes useful in phonetic correction with students called "false intermediates"; (2) a synthesis and a methodology of methods of phonetic correction of the "French R" with…

  8. Aspirations langagieres: Negociation et apprentissage du francais (Language Aspirations: Negotiation and Learning French).

    ERIC Educational Resources Information Center

    Lepetit, Daniel; Cichocki, Wladyslaw

    1990-01-01

    A survey of 130 beginning French students at the University of Windsor (Canada) focused on their second language aspirations, expectations, and anticipated needs. Interpersonal relations appear to be the primary motivator, with travel and instrumental motivation secondary. (20 references) (Author/MSE)

  9. Le Francais des Professions Scientifiques et Techniques (French for the Scientific and Technical Professions).

    ERIC Educational Resources Information Center

    Muller, Brigitte

    Two sequential courses in scientific and technical French developed as a supplement to third- and fourth-year college French, in response to expressed student and industry demand, had as their objectives to develop a general familiarity with products of the large French industrial companies and their United States affiliates and to develop means…

  10. Une Nouvelle Place pour le francais au Senegal? (A New Place for French in Senegal?)

    ERIC Educational Resources Information Center

    Ka, Omar

    1993-01-01

    A discussion of the role of the French language in Senegal first chronicles language and education policy from the colonial period until 1980, then cites research indicating that French is infrequently used for personal purposes. Recent initiatives to strengthen its status and usage, and obstacles to their success, are outlined. (MSE)

  11. Promouvoir le francais: Norvege, Chine, Israel (Promoting French: Norway, China, Israel).

    ERIC Educational Resources Information Center

    Grenet, Jean-Jack

    1994-01-01

    Strategies for promoting French and French language instruction are described. In Norway, a French popular music promotion has been launched cooperatively by record producers in both countries; a Chinese program links like organizations in the two countries; and in Israel, an initiative focuses on French song. (MSE)

  12. Chine: Les Chances du Francais (The Fortunes of the French Language in China).

    ERIC Educational Resources Information Center

    Shuning, Zhang

    1996-01-01

    Examines the current situation in China surrounding the teaching of French as a Foreign Language. After the decline of French teaching subsequent to the Cultural Revolution, the language returned to favor around 1970. Chinese students are infatuated with French; many study it as a first or second foreign language. Additionally, French literature…

  13. Sur les traces de l'heritage francais en Nouvelle-Angleterre: Boston (Tracing French Heritage in New England: Boston).

    ERIC Educational Resources Information Center

    Quintal, Claire

    This booklet highlights some of the more important elements of the French heritage in the Boston area, particularly during the Revolutionary period and the time of the establishment of many institutions of American life in New England. It is intended for secondary school students in a bilingual education setting who have at least an "intermediate…

  14. Vers un renouveau du "mirage americain" dans les lettres francais (Toward a Renewal of the "American Mirage" in French Literature)

    ERIC Educational Resources Information Center

    Huvos, Kornel

    1973-01-01

    Social and political commentary on the alternating images of America projected in French writing through the years; revised version of a paper presented at the 25th Annual Kentucky Foreign Language Conference, Lexington, Kentucky, April 28, 1972. (RL)

  15. Schwa au niveau avance du francais langue seconde (Schwa at the Advanced Level of French as a Second Language).

    ERIC Educational Resources Information Center

    Thomas, Alain

    2001-01-01

    Discusses part of a large-scale survey on the oral performance of advanced French-as-a-second-language students, as represented by recorded speech. Although schwa rarely leads to semantic confusions, its analysis in word-median or monosyllabic contexts shows interesting phonostylistic variations. (Author/VWL)

  16. Images de la variation du francais: dominantes et harmoniques, changements (Images of Variation in French: Dominant and Harmonic, Changes).

    ERIC Educational Resources Information Center

    Castellotti, Veronique; De Robillard, Didier

    2001-01-01

    This study gathered knowledge on an ill-explored field: attitudes toward French in France. It discusses ways and means to produce empirical data on this issue. Data indicate that the field described deserves investigation because, alongside standard French, the other "parlure" sampled in this study produce a variety of different attitudes and…

  17. Le francais assiste par ordinateur des colleges et des universities du Canada (French CALL in Canadian Colleges and Universities).

    ERIC Educational Resources Information Center

    Bougaieff, Andre

    This directory presents the results of a national survey of Canadian colleges and universities concerning faculty's use of computer-assisted French language instruction. The listings, arranged alphabetically by province or territory, and within these by institution, contain the responding faculty member's name, address, e-mail address, fax and…

  18. Theatre et enseignement du francais, langue etrangere (Theater and the Teaching of French as a Foreign Language).

    ERIC Educational Resources Information Center

    Maldaner, Aurea

    1980-01-01

    Discusses drama in foreign language instruction, especially as a means of improving oral expression. Two basic approaches are outlined and three techniques that have been used successfully with various age groups are described. (AMH)

  19. Pour Adolescent et Adulte, Francais Langue Etrangere, Niveau 1 (French as a Foreign Language, Level 1, for Adolescents and Adults)

    ERIC Educational Resources Information Center

    Gibert, Pierre

    1975-01-01

    This annotated bibliography lists dictionaries and reading materials including stories and legends, biographies, works relating to cinema, theatre and French civilization, magazines, and educational activities and games for introductory instruction of French as a foreign language to adults and adolescents. (Text is in French.) (CLK)

  20. Acquisition du francais par des immigrants adultes au Quebec (Acquisition of French by Adult Immigrants to Quebec).

    ERIC Educational Resources Information Center

    Painchaud, Gisele; And Others

    A study of the French language learning progress of immigrants to Quebec had four objectives: (1) to identify the functional level of oral French of two groups of immigrants after language training at one of the province's immigrant orientation centers; (2) to verify whether after a six month period of employment the language proficiency level has…

  1. Prenez le temps. Pour "faire francais" pensez au rhythme! (Take Your Time. To "Make French," Think about Rhythm!)

    ERIC Educational Resources Information Center

    Wioland, Francois; Wenk, Brian J.

    1983-01-01

    Transcripts of 11 dialogs based on rhythmic syllable groups, which make clear the rhythmic structures at the base of spoken French, are presented. Phonetic, lexical, and grammatical variation within the same rhythmic structure strengthen the exercise. The exercises are for intermediate and advanced adult students. (MSE)

  2. La Traduction des formes verbales du present francais en bafia (Translation of Verb Forms from the French Present into Bafia).

    ERIC Educational Resources Information Center

    Aroga Bessong, Dieudonne P.

    1982-01-01

    Translation into Bafia of the French present tense in its different values requires the translator to make some decisions based on semantic values and implied time factors. Specific considerations and problems are discussed with examples given. (MSE)

  3. Dictionnaire contextuel anglais-francais de l'energie solaire (Contextual English-French Dictionary on Solar Energy).

    ERIC Educational Resources Information Center

    Serre, Robert

    This English-French dictionary on solar energy is intended for translators and purports to contain all the elements necessary for doing quality translations. Each entry contains the following elements: (1) the basic English word with its synonyms and equivalents; (2) the definition in English and reference to its source; and (3) sentences or…

  4. Nous Parlons Francais. An Elementary Foreign Language Summer School Program, Grades K-8. A Guide for Teachers.

    ERIC Educational Resources Information Center

    McFadden, Virginia; And Others

    The teachers' guide for a 4-week, 4-hours-per-day elementary school summer program in French consists of information and suggestions for program implementation and materials for use with students. The introductory section contains a general program description, including broad program objectives for language comprehension, language production, and…

  5. Making "Wiggle Room" in French as a Second Language/Francais Langue Seconde: Reconfiguring Identity, Language, and Policy

    ERIC Educational Resources Information Center

    Byrd Clark, Julie

    2010-01-01

    In this two-year ethnographic study, I critically examined the problematic nature of the construct French as a Second Language (FSL), drawing specifically from the lived experiences of Canadian youth of Italian origin, participating in a teacher education course to prepare teachers of French. Using discourse analysis of interviews, observations,…

  6. Programme d'education de Maternelle--Francais Langue Premiere (Kindergarten Education Program--French as a First Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    The materials in this document discuss the Alberta (Canada) public school curriculum for French native language instruction for 5-year olds in preschool, intended for implementation in September 2000. The first part outlines the rationale and organization of the curriculum model and its five guiding principles. The second part describes the seven…

  7. L'Enseignement du francais par le chant au jardin d'enfants (Teaching French in Kindergarten Using the Song)

    ERIC Educational Resources Information Center

    Braem, Bernard

    1977-01-01

    A description of French instruction in kindergarten and primary grades in Louisiana by the method "Chantons avec Jeannot Lapin." It is an audio-visual approach whose goal is to sensitize students to the spoken language. A description of the methodology and a sample lesson plan are given. (Text is in French.) (AMH)

  8. Pour Enfant, Adolescent et Adulte, Francais Langue Seconde (French as a Second Language For Children, Adolescents and Adults)

    ERIC Educational Resources Information Center

    Bardolph, Jacqueline

    1975-01-01

    This annotated bibliography lists reading materials including stories, novels, poetry, documentary works, magazines and works dealing with French civilization to be used for instruction of French as a foreign language for adults, adolescents and children. (Text is in French.) (CLK)

  9. Polarisation Analysis Neutron Spectrometer, POLANO, at J-PARC - Concept and Magnetic Field Optimisation

    NASA Astrophysics Data System (ADS)

    Ohoyama, K.; Yokoo, T.; Itoh, S.; Nanbu, M.; Iwasa, K.; Ohkawara, M.; Kaneko, N.; Ino, T.; Hayashida, H.; Oku, T.; Kira, H.; Tasaki, S.; Takeda, M.; Kimura, H.; Sato, T. J.

    2016-04-01

    The status of the polarised neutron spectrometer constructed at the Japan Proton Accelerator Research Complex through a collaboration between Tohoku University and KEK will be reported. In particular, the optimisation of magnetic fields to minimise neutron- beam depolarisation using the finite element method will be discussed on the basis of several simulations using the finite element method.

  10. The fast extraction kicker power supply for the main ring of J-PARC

    NASA Astrophysics Data System (ADS)

    Koseki, Kunio

    2013-11-01

    An effect induced by parasitic inductance in a pulsed power supply for a fast extraction kicker was studied. The parasitic inductance in high voltage capacitors for a low impedance pulse forming network disturbs a sharp rise of an excitation current. A high voltage capacitor with a coaxial structure to minimize the parasitic inductance is proposed. The effectiveness was confirmed experimentally. An impedance mismatch by a leakage inductance of a pulse transformer in a transmission line was studied. The effect is serious at the flat-top period of the excitation current. By introducing a compensation circuit, which is composed by a capacitor and a resistor, impedance matching was established. The pulsed power supply for the fast extraction kicker was operated at a charging voltage of 30 kV. A required rise time of less than 1.1 μs was achieved. The flatness was also confirmed to be in an acceptable value of less than 1%.

  11. PARC Analysis of the NASA/GE 2D NRA Mixer/Ejector Nozzle

    NASA Technical Reports Server (NTRS)

    DeBonis, J. R.

    1999-01-01

    Interest in developing a new generation supersonic transport has increased in the past several years. Current projections indicate this aircraft would cruise at approximately Mach 2.4, have a range of 5000 nautical miles and carry at least 250 passengers. A large market for such an aircraft will exist in the next century due to a predicted doubling of the demand for long range air transportation by the end of the century and the growing influence of the Pacific Rim nations. Such a proposed aircraft could more than halve the flying time from Los Angeles to Tokyo. However, before a new economically feasible supersonic transport can be built, many key technologies must be developed. Among these technologies is noise suppression. Propulsion systems for a supersonic transport using current technology would exceed acceptable noise levels. All new aircraft must satisfy FAR 36 Stage III noise regulations. The largest area of concern is the noise generated during takeoff. A concerted effort under NASA's High Speed Research (HSR) program has begun to address the problem of noise suppression. One of the most promising concepts being studied in the area of noise suppression is the mixer/ejector nozzle. This study analyzes a typical noise suppressing mixer ejector nozzle at take off conditions, using a Full Navier-Stokes (FNS) computational fluid dynamics (CFD) code.

  12. THRESHOLD RESUMMATION EFFECTS IN THE POLARIZED DRELL-YAN PROCESS AT GSI AND J-PARC.

    SciTech Connect

    YOKOYA, H.; VOGELSANG, W.

    2006-04-20

    We present studies of QCD corrections to dilepton production in transversely polarized pp and {bar p}p scattering. In particular we briefly discuss the effects of NNLL threshold resummation on the rapidity distribution of the lepton pair.

  13. Planification de la maintenance d'un parc de turbines-alternateurs par programmation mathematique

    NASA Astrophysics Data System (ADS)

    Aoudjit, Hakim

    A growing number of Hydro-Quebec's hydro generators are at the end of their useful life and maintenance managers fear to face a number of overhauls exceeding what can be handled. Maintenance crews and budgets are limited and these withdrawals may take up to a full year and mobilize significant resources in addition to the loss of electricity production. In addition, increased export sales forecasts and severe production patterns are expected to speed up wear that can lead to halting many units at the same time. Currently, expert judgment is at the heart of withdrawals which rely primarily on periodic inspections and in-situ measurements and the results are sent to the maintenance planning team who coordinate all the withdrawals decisions. The degradations phenomena taking place is random in nature and the prediction capability of wear using only inspections is limited to short-term at best. A long term planning of major overhauls is sought by managers for the sake of justifying and rationalizing budgets and resources. The maintenance managers are able to provide a huge amount of data. Among them, is the hourly production of each unit for several years, the repairs history on each part of a unit as well as major withdrawals since the 1950's. In this research, we tackle the problem of long term maintenance planning for a fleet of 90 hydro generators at Hydro-Quebec over a 50 years planning horizon period. We lay a scientific and rational framework to support withdrawals decisions by using part of the available data and maintenance history while fulfilling a set of technical and economic constraints. We propose a planning approach based on a constrained optimization framework. We begin by decomposing and sorting hydro generator components to highlight the most influential parts. A failure rate model is developed to take into account the technical characteristics and unit utilization. Then, replacement and repair policies are evaluated for each of the components then strategies are derived for the whole unit. Traditional univariate policies such as the age replacement policy and the minimal repair policy are calculated. These policies are extended to build alternative bivariate maintenance policy as well as a repair strategy where the state of a component after a repair is rejuvenated by a constant coefficient. These templates form the basis for the calculation of objective function for the scheduling problem. On one hand, this issue is treated as a nonlinear problem where the objective is to minimize the average total maintenance cost per unit of time on an infinite horizon for the fleet with technical and economic constraints. A formulation is also proposed in the case of a finite time horizon. In the event of electricity production variation, and given that the usage profile is known, the influence of production scenarios is reflected on the unit's components through their failure rate. In this context, prognoses on possible resources problems are made by studying the characteristics of the generated plans. On the second hand, the withdrawals are now subjected to two decision criteria. In addition to minimizing the average total maintenance cost per unit of time on an infinite time horizon, the best achievable reliability of remaining turbo generators is sought. This problem is treated as a biobjective nonlinear optimization problem. Finally a series of problems describing multiple contexts are solved for planning renovations of 90 turbo generators units considering 3 major components in each unit and 2 types of maintenance policies for each component.

  14. PARCS: A Safety Net Community-Based Fitness Center for Low-Income Adults

    PubMed Central

    Keith, NiCole; de Groot, Mary; Mi, Deming; Alexander, Kisha; Kaiser, Stephanie

    2015-01-01

    Background Physical activity (PA) and fitness are critical to maintaining health and avoiding chronic disease. Limited access to fitness facilities in low-income urban areas has been identified as a contributor to low PA participation and poor fitness. Objectives This research describes community-based fitness centers established for adults living in low-income, urban communities and characterizes a sample of its members. Methods The community identified a need for physical fitness opportunities to improve residents’ health. Three community high schools were host sites. Resources were combined to renovate and staff facilities, acquire equipment, and refer patients to exercise. The study sample included 170 members ≥ age 18yr who completed demographic, exercise self-efficacy, and quality of life surveys and a fitness evaluation. Neighborhood-level U.S. Census data were obtained for comparison. Results The community-based fitness centers resulted from university, public school, and hospital partnerships offering safe, accessible, and affordable exercise opportunities. The study sample mean BMI was 35 ± 7.6 (Class II obesity), mean age was 50yr ± 12.5, 66% were black, 72% were female, 66% completed some college or greater, and 71% had an annual household income < $25K and supported 2.2 dependents. Participants had moderate confidence for exercise participation and low fitness levels. When compared to census data, participants were representative of their communities. Conclusion This observational study reveals a need for affordable fitness centers for low-income adults. We demonstrate a model where communities and organizations strategically leverage resources to address disparities in physical fitness and health. PMID:27346764

  15. Status of the RF-driven H⁻ ion source for J-PARC linac.

    PubMed

    Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Ueno, A; Shibata, T

    2016-02-01

    For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than once a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then. PMID:26932020

  16. Development of the charge exchange type beam scraper system at the J-PARC

    NASA Astrophysics Data System (ADS)

    Okabe, K.; Yamamoto, K.; Kinsho, M.

    2016-03-01

    Improvement in injection beam quality at the Japan Proton Accelerator Research Complex 3-GeV rapid cycle synchrotron is to mitigate beam loss at the injection section. We developed a charge-exchange type scraper system with a thin carbon foil to collimate the beam halo in the injection beam line of the synchrotron. The key issue to realize the scraper is a reduction of the beam loss induced by the multiple-scattering effect of charge-exchange foil placed at the scraper head. In order to determine the adequate foil thickness, a charge-exchange efficiency of a carbon foil and particle-tracking simulation study of the collimated beam have been performed assuming a realistic halo at the scraper section. Using the results of this study, we chose the thickness of a 520 μg /cm2 as the scraper foils to mitigate radiation dose around the L3BT scraper section. A charge-exchange scraper system that prevents the emission of radioactive fragments of the carbon foil was build. The system was put into operation to prove its effectiveness in eliminating the beam halo. From the result of a preliminary beam experiments, we confirmed that the installed scrapers eliminate a transverse beam tail or halo. After two days of operation with beam collimation, the radiation dose level around the scraper section was a tolerable one for the hands-on maintenance.

  17. Le plutonium et la cohérence du parc électronucléaire français

    NASA Astrophysics Data System (ADS)

    Dautray, Robert; Friedel, Jacques

    2013-02-01

    By reducing by 20 to 30% the French production of nuclear energy, one would suppress all the reactors functioning presently with the MOX fuel. This is the fuel which should be needed by the fourth generation breeder fast neutron reactor. This note details the negative consequences for any nuclear role for France at medium and long time.

  18. Evaluation and treatment of patients with lower extremity peripheral artery disease: consensus definitions from Peripheral Academic Research Consortium (PARC).

    PubMed

    Patel, Manesh R; Conte, Michael S; Cutlip, Donald E; Dib, Nabil; Geraghty, Patrick; Gray, William; Hiatt, William R; Ho, Mami; Ikeda, Koji; Ikeno, Fumiaki; Jaff, Michael R; Jones, W Schuyler; Kawahara, Masayuki; Lookstein, Robert A; Mehran, Roxana; Misra, Sanjay; Norgren, Lars; Olin, Jeffrey W; Povsic, Thomas J; Rosenfield, Kenneth; Rundback, John; Shamoun, Fadi; Tcheng, James; Tsai, Thomas T; Suzuki, Yuka; Vranckx, Pascal; Wiechmann, Bret N; White, Christopher J; Yokoi, Hiroyoshi; Krucoff, Mitchell W

    2015-03-10

    The lack of consistent definitions and nomenclature across clinical trials of novel devices, drugs, or biologics poses a significant barrier to accrual of knowledge in and across peripheral artery disease therapies and technologies. Recognizing this problem, the Peripheral Academic Research Consortium, together with the U.S. Food and Drug Administration and the Japanese Pharmaceuticals and Medical Devices Agency, has developed a series of pragmatic consensus definitions for patients being treated for peripheral artery disease affecting the lower extremities. These consensus definitions include the clinical presentation, anatomic depiction, interventional outcomes, surrogate imaging and physiological follow-up, and clinical outcomes of patients with lower-extremity peripheral artery disease. Consistent application of these definitions in clinical trials evaluating novel revascularization technologies should result in more efficient regulatory evaluation and best practice guidelines to inform clinical decisions in patients with lower extremity peripheral artery disease.

  19. Instrumental design and expected performance of coupled-moderator near-backscattering spectrometer at J-PARC

    NASA Astrophysics Data System (ADS)

    Takahashi, N.; Shibata, K.; Sato, T. J.; Tamura, I.; Kajimoto, R.; Harjo, S.; Oikawa, K.; Arai, M.; Mezei, F.

    2007-11-01

    A near-backscattering (n-BS) crystal-analyzer neutron inelastic spectrometer, DIANA, has been proposed for construction at Japan Proton Accelerator Research Complex. It has originally been designed to view a decoupled non-poisoned moderator in order to obtain high intensity and good energy resolution. Recently, we have reconsidered the instrumental parameters including the type of moderator, by performing Monte-Carlo simulations in order to obtain better performance. Among four virtual n-BS spectrometers on different beam sources moderators, a coupled-moderator-source spectrometer has shown the best performance, i.e. compared to the original DIADA design between ninefold and fivefold enhanced intensities have been obtained with 21%-better to 35%-worse energy resolutions.

  20. Conceptual design of a polarized 3He neutron spin filter for polarized neutron spectrometer POLANO at J-PARC

    NASA Astrophysics Data System (ADS)

    Ino, T.; Ohoyama, K.; Yokoo, T.; Itoh, S.; Ohkawara, M.; Kira, H.; Hayashida, H.; Sakai, K.; Hiroi, K.; Oku, T.; Kakurai, K.; Chang, L. J.

    2016-04-01

    A 3He neutron spin filter (NSF) has been designed for a new polarized neutron chopper spectrometer called the Polarization Analysis Neutron Spectrometer with Correlation Method (POLANO) at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Research Complex. It is designed to fit in a limited space on the spectrometer as an initial neutron beam polarizer and is polarized in situ by spin exchange optical pumping. This will be the first generation 3He NSF on POLANO, and a polarized neutron beam up to 100 meV with a diameter of 50 mm will be available for research on magnetism, hydrogen materials, and strongly correlated electron systems.

  1. First Imaging Experiment of a Lithium Ion Battery by a Pulsed Neutron Beam at J-PARC/MLF/BL09

    NASA Astrophysics Data System (ADS)

    Kino, Koichi; Yonemura, Masao; Kiyanagi, Yoshiaki; Ishikawa, Yoshihisa; Parker, Joseph. Don.; Tanimori, Toru; Kamiyama, Takashi

    We obtain the transmission image of a commercial lithium ion (Li-ion) battery using a pulsed neutron beam at the beamline 09 of the Materials and Life Science Experimental Facility at the Japan Proton Accelerator Research Complex. The purpose of this study is to improve the performance of the Li-ion battery by nondestructive observation of its charging and discharging. The transmission images for three charge states (3.2 V, 3.7 V, and 4.2 V) reveal differences between these three states, which we attribute to electrolyte migration. The transmission spectra show Bragg edges originating from the electrodes, current collectors, and battery vessel. Although the battery as a whole has the expected relation between the charge accumulation and the quantity of lithium amounts in the positive and negative electrodes, a portion of the battery deviates from this relation, which may imply a position dependent charging in the battery.

  2. La comprehension du francais parle au niveau avance: un exemple de test (Comprehension of Spoken French at the Advanced Level: A Test Sample).

    ERIC Educational Resources Information Center

    Mauriac, Paul

    1980-01-01

    The use of taped radio programs is suggested for testing advanced level French comprehension. In the testing technique described less attention is given to program content than to style and language usage. A sample test is presented. (MSE)

  3. Communication et reflexion metalinguistique dans l'apprentissage du francais par les adultes (Communication and Metalinguistic Reflection in French Language Learning by Adults).

    ERIC Educational Resources Information Center

    Galatanu, Olga

    A discussion of the relationships between communication in a foreign language and metalinguistic thought given to that language focuses on formal French language learning by adults in their home countries. Experience with adult language learners suggests a resistance to grammatical explanations but an openness to explanations of meaning. It would…

  4. Synthese et methodologie des moyens de correction phonetique du "R" francais enseigne aux anglophones (Methods of Correcting the Pronunciation of the French "R" for English Speakers).

    ERIC Educational Resources Information Center

    Lebel, Jean-Guy

    The present work begins with a phonetic description of the acceptable French /R/ and descriptions of several allophones of English /R/ which must be avoided while learning the French. Various theories are discussed concerning the relationship between the position of the /R/ in an utterance and the difficulty students have in pronouncing it…

  5. ONU Geneve: quel avenir pour le francais? Silence, on coule! (ONU Geneva: What Future for French? Quiet, We're Sinking!)

    ERIC Educational Resources Information Center

    Lebreton, Jean-Michel; And Others

    1986-01-01

    Two articles address change and conflict concerning the French language. One discusses the comparative roles of English and French at the United Nations office in Geneva; the other is in response to the opinions of Philippe de Saint Robert on the need to protect French from change. (MSE)

  6. Unite et diversite de l'action pedagogique des services francais a l'etranger (The Unity and Diversity of Pedagogical Activities of French Services Abroad)

    ERIC Educational Resources Information Center

    Gautherot, Jean Marie

    1978-01-01

    A report on the responses to a questionnaire on the activities, relations with collaborators, organization of educational services and methods of implementation. Seventeen countries are represented in the survey. (AMH)

  7. Un Exemple d'Algorithme: Mettre un Substantif Francais au Pluriel. (An Example of Algorithm: Putting French Nouns into the Plural).

    ERIC Educational Resources Information Center

    de Saint Andre, Ph. Durant

    1987-01-01

    Presents a computer interpretation of the consistencies as well as inadequacies of grammar rules in changing singular forms to plural. A correlative algorithm is discussed for the purpose of enhancing the present logical system of changing singulars to plurals. (TR)

  8. Valeurs modales du futur et du conditionnel et leurs emplois en francais contemporain (Modality of the Future and Conditional and Their Uses in Contemporary French).

    ERIC Educational Resources Information Center

    Gobert, David L.; Maisier, Veronique

    1995-01-01

    Offers an analysis of written and oral texts and a questionnaire on the contemporary use of future and conditional modals in French, and reviews the treatment of these verb forms by grammarians and language learning authors. Findings suggest that grammar books and manuals offer guidance on the written use of the modals, rather than the oral usage.…

  9. Images de la societe dans le cinema francais des dix dernieres annees (Images of Society in French Film in the Last Ten Years).

    ERIC Educational Resources Information Center

    Esteve, Michel

    1980-01-01

    It is proposed that film has become a mirror of French society and of social change in France since 1968. It reflects changes in life-style, evolution of morals, fluctuations in fashion, and changes in urban and rural landscapes. However, it rarely questions society seriously. (MSE)

  10. Systeme des fautes et correction phonetique des Anglais qui apprennent le francais (System of Errors and Phonetic Correction of English Speakers Learning French)

    ERIC Educational Resources Information Center

    Lebrun, Claire

    1975-01-01

    This article provides the results of an investigation of the system of pronunciation faults of English speakers learning French, and describes means of correction based on the verbo-tonal system. (Text is in French.) (CLK)

  11. Vers un nouveau manuel de stylistique comparee du francais et de l'anglais (Toward a New Comparative Style Manual for French and English).

    ERIC Educational Resources Information Center

    Kingstone, Basil

    1989-01-01

    The features necessary in an introductory course on translation are described, and the standard text for this kind of course is evaluated with reference to two critical accounts of it. Differences in general structure between the standard text and one in preparation and some theories needing modification are examined. (Author/MSE)

  12. Difficultes phonetiques de l'acquisition du francais langue seconde (Phonetic Difficulties in the Learning of French as a Second Language).

    ERIC Educational Resources Information Center

    Huot, France

    The goal of this study is to discover the phonetic difficulties encountered in the acquisition of French as a second language by English-speaking children. The children are studying French in a total immersion situation without benefit of structural exercises or special French language laboratory classes. Of particular interest here is the extent…

  13. La francophonie dans les manuels de francais langue seconde: apports et limites (Francophony in French Second Language Textbooks: Contributions and Limitations).

    ERIC Educational Resources Information Center

    Fleig-Hamm, Christiane

    1998-01-01

    This study examined representation of francophone regions other than France in readings and activities in French second-language textbooks published since 1995. The model of representation used shows the richness and variety of the cultures, contains no inaccurate information, and gives a realistic portrayal devoid of colonialistic and…

  14. L'enseignement du francais a des clienteles allophones: aspects discursifs de la langue ecrite (Teaching French to Language Minority Clienteles: Discourse Aspects of Written Language).

    ERIC Educational Resources Information Center

    Therien, Michel

    This study investigated the discourse elements that teachers focus on in teaching French to multiethnic groups, and examined the extent to which teachers take into account the different cultural backgrounds of these students. Data are derived primarily from the observation of videotaped classroom activities. The subjects in the study were students…

  15. Vers une culture des affaires? Mentalites, comportements, representations dans la classe de francais commercial (Toward a Business Culture? Attitudes, Behaviors, and Representations in the Commercial French Classroom).

    ERIC Educational Resources Information Center

    Bousquet, Gilles

    1993-01-01

    An exploration of the nature and range of international expertise necessary for students and users of commercial French attempts to note the points where knowledge of law, politics, culture, and business practice takes over from mere accumulation of facts or linguistic competence to facilitate genuine, productive, and culturally appropriate…

  16. Recherche empirique sur l'effet de la musique dans l'enseignement suggestopedique du francais (Empirical Research on the Effect of Music in Suggestopedic French Instruction).

    ERIC Educational Resources Information Center

    Schiffler, Ludger

    1986-01-01

    A study of the effectiveness of music techniques in French second-language instruction using the suggestopedic approach is reported. The study attempts to control for variations commonly found in experimental conditions. (MSE)

  17. "Peau d'Ane" videodisque interactif de francais, langue etrangere ("Donkey's Hide," an Interactive Videodisc in French as a Second Language).

    ERIC Educational Resources Information Center

    Garrigues, Mylene

    1985-01-01

    The characteristics of videodisc technology are outlined, and a project undertaken to create an interactive videodisc for French language instruction is described, including the efforts to eliminate physical barriers between the computer and the user, pedagogical strategy and material, programing technicalities, and other details of production.…

  18. Le Certificat Pratique de la CCIP et la Traduction dans les Cours de francais Commercial (The CCIP Certificate and Translation in Business French Courses).

    ERIC Educational Resources Information Center

    Cote, Paul Raymond

    1996-01-01

    Discusses the importance of professional translators in the milieu of the European Community and the global economy. The article focuses on the changes occurring within the French educational system in order to accomodate this reality by preparing students for a practical translation test in order to earn a certificate in the translation of…

  19. Problemes d'analyse du discours. Essai de description du discours francais sur la Chine (Problems in Discourse Analysis. An Attempt to Describe French Discourse on China).

    ERIC Educational Resources Information Center

    Marindin, Jean-Marie

    1979-01-01

    The following topics are developed: (1) the problematic aspect of the analysis of French discourse, an introduction to methods, theories and applications; (2) the proposals of M. Pecheux; (3) precisions to render operative definitions derived in the proposals; (4) the Macciocchi manner of speaking; and (5) the Peyrefitte manner of speaking. (AMH)

  20. Variation et heterogeneite de recits en francais de jeunes eleves tunisiens (Variation and Heterogeneity of the French Narrative Productions of Young Tunisian Students).

    ERIC Educational Resources Information Center

    Anane, Chiraz

    2001-01-01

    This study analyzes narrative productions in the French of 10 Tunisian pupils selected from 2 schools (1 in an urban area, 1 in a rural area) in Tunisia (Tunis). The purpose of the study was to observe the development of the French language in native Tunisian Arabic speakers. Particular attention is focused on the narrative structure and time…

  1. Teaching English Language Arts to Francophone Program Students, Grades 3 to 9: Bridging the Francais and English Language Arts (ELA) Programs of Study.

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This document is the first in a 3-part collection titled "Teaching English Language Arts (ELA) to Francophone Program Students" to be used primarily by ELA teachers in their efforts to ensure that francophone program students build on their established French language skills when learning English. It is designed to show that a strong correlation…

  2. Document d'accompagnement du programme d'education de maternelle: Francais langue premiere (Manual in Support of the French as a First Language Kindergarten Program).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This document is designed for use by teachers of French-as-a-first-language kindergarten programs in Alberta. It outlines the vision, elements, and goals of the program, explains the context of the francophone environment in Alberta, and provides practical tools for the implementation of the program in consideration of the specific needs of the…

  3. Representations et Competencies vis-a-vis de l'Ecrit Chez des Enfants Francais et Allemands d'Age Prescolaire.

    ERIC Educational Resources Information Center

    Preteur, Yves; Louvet-Schmauss, Eva

    1994-01-01

    Compares German and French preschool children's attitudes about school and literacy. Notes that French preschools aim to prepare children for primary education, whereas German preschools give priority to learning through play. Finds that children developed attitudes in line with their preschool system and that only French children from deprived…

  4. Role-Playing as a Method of Teaching Civilization.

    ERIC Educational Resources Information Center

    Corbin, Diane H.

    This paper describes how role-playing was used in a French culture and civilization class at Eastern Washington State College. The class was conducted entirely in French, and each class member read the same material for each day. L. Wylie's "Les Francais" was used as the class text, and "Comment vivent les Francais" by Girod and Grand-Clement was…

  5. Patterns and Policies: The Changing Demographics of Foreign Language Instruction. Issues in Language Program Direction: A Series of Annual Volumes.

    ERIC Educational Resources Information Center

    Liskin-Gasparro, Judith E., Ed.

    This collection of papers is divided into three parts. Part 1, "Changing Patterns: Curricular Implications," includes "Basic Assumptions Revisited: Today's French and Spanish Students at a Large Metropolitan University" (Gail Guntermann, Suzanne Hendrickson, and Carmen de Urioste) and "Le Francais et Mort, Vive le Francais: Rethinking the Function…

  6. Parks and People. A European Conference for Naturparke Parcs Naturels/National Parks (U.K.) and Equivalent Reserves (Losehill Hall, Castleton, England, September 25-29, 1978).

    ERIC Educational Resources Information Center

    Youel, Alex J.

    Presented are the proceedings of the European Conference for National Parks and Equivalent Reserves held at the Peak National Park Study Centre, Castleton, England in 1978. Thirty-nine representatives from 10 countries focused on the relationship between the parks and the people connected with them (the local people, the visitors, and the park…

  7. Physical activity and the rejuvenation of Connswater (PARC study): protocol for a natural experiment investigating the impact of urban regeneration on public health

    PubMed Central

    2013-01-01

    Background There is a dearth of evidence regarding the impact of urban regeneration projects on public health, particularly the nature and degree to which urban regeneration impacts upon health-related behaviour change. Natural experiment methodology enables comprehensive large-scale evaluations of such interventions. The Connswater Community Greenway in Belfast is a major urban regeneration project involving the development of a 9 km linear park, including the provision of new cycle paths and walkways. In addition to the environmental improvements, this complex intervention involves a number of programmes to promote physical activity in the regenerated area. The project affords a unique opportunity to investigate the public health impact of urban regeneration. Methods/Design The evaluation framework was informed by the socio-ecological model and guided by the RE-AIM Framework. Key components include: (1) a quasi-experimental before-and-after survey of the Greenway population (repeated cross-sectional design), in tandem with data from a parallel Northern Ireland-wide survey for comparison; (2) an assessment of changes in the local built environment and of walkability using geographic information systems; (3) semi-structured interviews with a purposive sample of survey respondents, and a range of community stakeholders, before and after the regeneration project; and (4) a cost-effectiveness analysis. The primary outcome is change in proportion of individuals identified as being regularly physically active, according to the current UK recommendations. The RE-AIM Framework will be used to make an overall assessment of the impact of the Greenway on the physical activity behaviour of local residents. Discussion The Connswater Community Greenway provides a significant opportunity to achieve long-term, population level behaviour change. We argue that urban regeneration may be conceptualised meaningfully as a complex intervention comprising multiple components with the potential, individually and interactively, to affect the behaviour of a diverse population. The development and implementation of our comprehensive evaluation framework reflects this complexity and illuminates an approach to the empirical, rigorous evaluation of urban regeneration. More specifically, this study will add to the much needed evidence-base about the impact of urban regeneration on public health as well as having important implications for the development of natural experiment methodology. PMID:24103381

  8. The Evaluation of the Residual Dose Caused by the Large-Angle Foil Scattering Beam Loss for the High Intensity Beam Operation in the J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Kato, Shinichi; Yamamoto, Kazami; Harada, Hiroyuki; Hotchi, Hideaki; Saha, Pranab K.; Kinsho, Michikazu

    The Japan Proton Accelerator Research Complex 3-GeV rapid cycling synchrotron (RCS) has adopted the multi-turn charge-exchange injection scheme that uses H- beams. During injection, both the injected and circulating beams scatter from the charge-exchange foil. Therefore, the beam loss caused by the large-angle scattering from the foil occurs downstream of the injection point. For countermeasure against the uncontrolled beam loss, a new collimation system was developed and installed in the summer shutdown period in 2011. During beam commissioning, this uncontrolled beam loss was successfully localized for a 300 kW beam. Since the present target power of the RCS is 1 MW, the accurate simulation model to reproduce experimental results has been constructed in order to evaluate residual dose at higher power operation.

  9. La theorie autrement (Theory in Another Light).

    ERIC Educational Resources Information Center

    Bertocchini, Paola; Costanzo, Edwige

    1985-01-01

    Outlines a technique using articles from "Le Francais dans le Monde" to teach reading comprehension and theory simultaneously to teachers of French as a second language. Describes a program in Italy using this approach. (MSE)

  10. Pratique des relations internationales en francais. Deuxieme partie: Ecrit: de l'analyse de discours aux pratiques pedagogiques (The Practice of International Relations in French. Part Two: Writing: From Discourse Analysis to Pedagogical Practice).

    ERIC Educational Resources Information Center

    Michaelides, Maro P.

    1985-01-01

    Discusses the use of discourse analysis with students who are familiar with international relations and interested in understanding discourse organization in greater depth. The discussion indicates how such a procedure can help students understand and produce texts in their field. Several examples are included. (MSE)

  11. La Technologie au service de l'enseignement/apprentissage du francais langue seconde: Survol du projet RECALL, 1985-91 (Foreign Language Instruction and Learning and Educational Technology: Survey of Project RECALL, 1985-91).

    ERIC Educational Resources Information Center

    Ducretet, Marie-Paule; And Others

    1992-01-01

    A French curriculum development and research project at Erindale College (Canada), established in 1985, studies and initiates incorporation of computer technology into the University of Toronto French program. Specific objectives include evaluation and adaptation of existing software, development of an undergraduate course in computer applications…

  12. Resultats de l'enquete nationale sur les programmes de formation des enseignants de francais langue seconde au Canada (Results of the National Study for Teacher Education Programs for French Second Language Teachers in Canada).

    ERIC Educational Resources Information Center

    Boutin, France; Chinien, Christian; Boutin, Jean-Luc

    The implications of Canada's national study of core French instruction for second language (L2) teacher education in that country are examined. Literature on the study's impact on language teaching philosophy and policy and on French immersion instruction is reviewed, and a survey of 36 Canadian schools of education is reported. The questionnaire…

  13. Francais de base. Programme de 9 ans, materiel didactique: 4e, 5e et 6e annees (Core French. Nine-Year Study Program, Instructional Materials: 4th, 5th and 6th Grades).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    Official instructional materials for the first three years (grades 4-6) of the Manitoba Department of Education's core French language program consist of units in geography, weather and calendars, holidays, and music designed for each of the three instructional levels. The units on geography focus on Manitoba and Canada. Units on the calendar and…

  14. Avez-vous vu la meme chose que les Francais? Stereotypes et documents authentiques video. (Did You See the Same Thing as the French? Stereotypes and Authentic Video Documents).

    ERIC Educational Resources Information Center

    Wilczynska, Weronika

    1990-01-01

    This discussion treats cultural stereotypes as a significant issue in second-language instruction, and examines the role of video documents from the mass media in helping students perceive and understand such stereotypes. (MSE)

  15. Vue d'ensemble du programme d'enseignement par immersion partielle (francais, langue seconde) au Conseil Scolaire Lakeshore (An Overview of the Partial Immersion Educational Program [French, Second Language] in the Lakeshore School District)

    ERIC Educational Resources Information Center

    Malboeuf, Roger

    1978-01-01

    An overview of the program in grades 4-6. The objectives, particularly those concerning affective and psycho-motor development and communication, the role of the teacher, the division of time, and the subjects taught in English are discussed. Reasons for this kind of program organization are given. (Text is in French.) (AMH)

  16. Le "Futur Anterieur" comme temps du passe: Remarques sur un emploi particulier frequent du "futur anterieur" en francais. (The "Futur Anterieur" as Past Tense: Remarks on a Particular Frequent Use of the "Futur Anterieur" in French).

    ERIC Educational Resources Information Center

    Steinmeyer, Georg

    1987-01-01

    Explains how the "futur anterieur" is often used to indicate past time in French grammar. Using authentic evidence from a news magazine, some hypotheses on the conditions of use of the "futur anterieur" are suggested. Criteria for distinguishing past tense functions from modal functions are also presented. (TR)

  17. Une verification de l'efficacite de la methode verbo-tonale: apprentissage du /y/ francais par des americanophones (Testing of the Efficiency of the Verbo-Tonal Method: The learning of the French /y/ by Speakers of American English)

    ERIC Educational Resources Information Center

    Fort, Paul; And Others

    1976-01-01

    This article describes a study designed to test the basic notions of the verbo-tonal method of error correction in second language learning, a method based on an awareness of the phonological system of the speaker's native language and its influence on the phonological system of the target language. (Text is in French.) (CLK)

  18. Une epreuve orale de francais en fin d'etudes de gestion. Construction et implications pedagogiques (An Oral French Exam at the End of a Marketing Program. Construction and Pedagogical Implications).

    ERIC Educational Resources Information Center

    Crawshaw, Robert H.

    1984-01-01

    An oral language test administered at the end of a four-year program combining business administration and French is described. The test consists of the formal presentation of a report including numbers, graphics, and text, a discussion of a theoretical issue, and interview. (MSE)

  19. De L'Economie des moyens linguistiques en francais et en anglais dans l'usage standard contemporain (On the Economy of Linguistic Means in French and English Standard Contemporary Usage).

    ERIC Educational Resources Information Center

    Calve, Pierre

    1989-01-01

    The conciseness and "ease of use" often attributed to North American English relative to French in standard contemporary usage is explained in terms of English morpho-syntactic structure and of the values of the classical norm and rhetoric affecting French. (Author/MSE)

  20. Ambiguites Semantiqes dues au contact des deux langues, notamment du grec moderne et du francais (Semantic Ambiguities Resulting from the Contact of Two Languages, in Particular Modern Greek and French).

    ERIC Educational Resources Information Center

    Teta, Simeonidou-Christidou

    The difficulties presented by the semantic baggage that a word/phrase carries as it is translated from one language (French) into another language (Greek) are discussed. Numerous examples of these difficulties, drawn from magazines and works of fiction, are provided. The phenomenon of linguistic borrowing is highlighted. (SR)

  1. Francais de base. Programme de 9 ans, materiel didactique: 7e, 8e et 9e annees (Core French. Nine-Year Study Program, Instructional Materials: 7th, 8th and 9th Grades).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    Official instructional materials for the second three years (grades 7-9) of the Manitoba Department of Education's core French language program are presented. These materials, intended for teachers, consist of units of instruction for each year, which contain notes for the teacher, suggestions for class activities, materials for student use, and…

  2. Le langage des "gendarmes" et des "voleurs": etude comparative du vocabulaire de la pegre et de la police en francais et en anglais ("Cops" and "Robbers" Language: A Comparative Study of the Underworld and Police Vocabulary of French and English).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1981-01-01

    Discusses the meaning and origins of the word "argot," its cryptic character, and its function in a closed social group, focusing on a comparative description of the French and Anglo-American vocabulary of the underworld and the police. Comments on shared traits and provides an insight into the differences. (MES)

  3. Bibliographie annotee 4-6--Francais langue seconde-immersion: Selection d'ouvrages de la litterature jeunesse. Supplement 2001 (Annotated Bibliography 4-6--French as a Second Language-Immersion: Selection of Works from Children's Literature. Supplement 2001).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    The document comprises 42 inserts to be included in the List of Books (4-6) for French as a Second Language (Immersion)--a selection of works of youth literature--published by Alberta Learning in 2000. Thirty-seven of the items appeal to the world of imagination and esthetics, and five items are of an informative nature. An appendix, entitled "How…

  4. Evaluation du systeme de traduction automatique SYSTRAN anglais-Francais, version 1978, de la Commission des Communautes Europeennes (Evaluation of the English-French SYSTRAN Machine Translation System, 19 version, of the Commission of European Communities).

    ERIC Educational Resources Information Center

    Van Slype, Georges

    1979-01-01

    Describes the French-English version of the SYSTRAN machine translation system, used by the Commission of European Communities, and an evaluation study which examined the quality, cost, and weaknesses of the system. The study concluded that this type of system is useful for "pretranslation" and "rough" translation only. (AM)

  5. Essais d'application d'un cadre de reference pragmatique a la realisation de materiels d'apprentissage du francais langue etrangere (Attempts to Apply a Pragmatic Framework to Materials Development for French as a Foreign Language)

    ERIC Educational Resources Information Center

    Richterich, Rene

    1977-01-01

    New needs in foreign language teaching call for new approaches to teaching methods and materials. This article illustrates how a pragmatic reference framework, involving speech acts and communication situations, can be used to choose or develop learning materials, specifically for French as second language. (Text is in French.) (AM)

  6. Project experimentale sur le bilinguisme Creole-Francais au niveau de l' enseignement primaire en Haiti (Experimental Project on Creole-French Bilingualism at the Primary Level in Haiti).

    ERIC Educational Resources Information Center

    de Ronceray, Hubert; Petit-Frere, Serge

    1975-01-01

    This is a progress report on the first year of an experimental bilingual education project for primary education in Haiti, sponsored by the Centre Haitien d' Investigation en Sciences Sociales (CHISS), The center's goal was to carry out a scientific project, to secure the facts from emotional and political prejudice. The point is to show the…

  7. Vingt-cinq ans dans l'evolution d'une politique de diffusion du francais (Twenty-Five Years in the Evolution of the Politics of the Diffusion of French).

    ERIC Educational Resources Information Center

    Boulanger, Lionel; Daniel, Pierre

    1984-01-01

    The theme of a conference in honor of the centennial of a famous French teaching institution was the 25-year French policy of spreading the French language internationally. Discussions focused on the cultural politics involved and their institutionalization, and the evolution of methods to carry out this policy through the medium of linguistic…

  8. Affirming Francophone Education: Foundations and Directions. A Framework for French First Language Education in Alberta = Affirmer l'education en francais langue premiere: fondements et orientations. Le cadre de l'education francophone en Alberta.

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This booklet presents a clear and succinct description of the educational needs of francophone students, families, and communities, and how this all fits into the constitutional requirements of Canada as directed by the 1982 Canadian Charter of Rights and Freedoms and all subsequent amendments and Canadian Supreme Court rulings. It identifies the…

  9. Banque de strategies d'ecoute pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in immersion programs. It provides a host of strategies for teaching listening skills in the classroom in Grades 1 through 7. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  10. Banque de strategies de lecture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching reading skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  11. Banque de strategies de lecture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching reading skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  12. Banque de strategies de production orale pour un enseignement explicite de la 6e a la 12e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  13. Banque de strategies de production orale pour un enseignement explicite de la 1re a la 7e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  14. Banque de strategies d'ecriture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching writing skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  15. Banque de strategies d'ecriture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for the Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, written in French, intended for the instruction of both French as a first language and French as a second language (immersion), provides a host of strategies for teaching writing skills in the classroom (grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the…

  16. Banque de strategies d'ecoute pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching listening skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It…

  17. Testing Lorentz Invariance with Laser-Cooled Cesium Atomic Frequency Standards

    NASA Technical Reports Server (NTRS)

    Klipstein, William M.

    2004-01-01

    This slide presentation reviews the Lorentz invariance testing during the proposed PARCS experiment. It includes information on the primary atomic reference clock in space (PARCS), cesium, laser cooling, and the vision for the future.

  18. European Heritage Landscapes. An Account of the Conference on Planning and Management in European Naturparke/Parcs Naturels/National Parks (U.K.) and Equivalent Category "C" Reserves (Losehill Hall, Castleton, England, September 26-30, 1977).

    ERIC Educational Resources Information Center

    Smith, Roland

    Presented are the proceedings of the Conference on Planning and Management in European National Parks and equivalent Category "C" reserves held at the Peak National Park Study Center, Castleton, England, in 1977. Fifty-two representatives from 16 countries focused practical solutions to management and planning problems in national parks. (BT)

  19. UniProt archive.

    PubMed

    Leinonen, Rasko; Diez, Federico Garcia; Binns, David; Fleischmann, Wolfgang; Lopez, Rodrigo; Apweiler, Rolf

    2004-11-22

    UniProt Archive (UniParc) is the most comprehensive, non-redundant protein sequence database available. Its protein sequences are retrieved from predominant, publicly accessible resources. All new and updated protein sequences are collected and loaded daily into UniParc for full coverage. To avoid redundancy, each unique sequence is stored only once with a stable protein identifier, which can be used later in UniParc to identify the same protein in all source databases. When proteins are loaded into the database, database cross-references are created to link them to the origins of the sequences. As a result, performing a sequence search against UniParc is equivalent to performing the same search against all databases cross-referenced by UniParc. UniParc contains only protein sequences and database cross-references; all other information must be retrieved from the source databases.

  20. Melanges Pedagogiques (Pedagogical Mixture), 1986/87.

    ERIC Educational Resources Information Center

    Melanges Pedagogiques, 1987

    1987-01-01

    The 1986/87 issue of the journal on second language teaching and learning contains seven articles in French and four in English, including: "Learning How To Learn English"; "Socrate est-il un chat? Pratiquer le syllogisme pour apprendre a argumenter (Is Socrates a Cat? Practicing Syllogisms To Learn To Argue)"; "La production orale en francais des…

  1. Actes du colloque: Tendances actuelles de la recherche sur la langue parlee (Conference Presentations: Current Trends in Research on Oral Language).

    ERIC Educational Resources Information Center

    Auger, Julie, Ed.

    Student papers presented at a sociolinguistics conference include: "La variation phonologique [d'une voyelle] a Hull"; "La force illocutoire des pronoms personnels 'je' et 'tu' en tant qu'insignes des places d'ou parlent les femmes et les hommes"; "L'emploi des modes indicatif et subjonctif dans le francais parle de la ville de Quebec"; "A Study…

  2. EPA/IFP EUROPEAN WORKSHOP ON THE EMISSION ON NITROUS OXIDE FROM FOSSIL FUEL COMBUSTION

    EPA Science Inventory

    The report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increas...

  3. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (12th, Quebec City, Canada, March 26-27, 1998).

    ERIC Educational Resources Information Center

    Boissonneault, Chantal, Ed.

    Papers on language research include: "L'expression de l'opposition en Latin" ("The Expression of Opposition in Latin" (Claude Begin); "Le francais de l'Abitibi: characteristiques phonetiques et origine socio-geographique des locuteurs" ("The French of Abitibi: Phonetic Characteristics and Socio-Geographic Origin of Speakers") (Chantal…

  4. Paradoxes in French-Language Instruction: Recent Social and Historical Research on Literacy in France

    ERIC Educational Resources Information Center

    Rockwell, Elsie; Galvao, Ana Maria

    2012-01-01

    This essay on three recent books by outstanding scholars--"La raison scolaire" by Bernard Lahire, "Histoire de l'enseignement du francais du XVII[superscript e] au XX[superscript e] siecle" by Andre Chervel, and "L'ecole et la lecture obligatoire" by Anne-Marie Chartier--offers the opportunity to acquaint readers with French research on teaching…

  5. Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

    ERIC Educational Resources Information Center

    Mazur, Gertrud S., Ed.

    The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic Grammar and Applied…

  6. Current Approaches to the Teaching of Foreign Languages.

    ERIC Educational Resources Information Center

    Barrett, Martin T.; And Others

    Five papers presented at a language conference are compiled in this report. They include: (1) "Le Francais au Pot-Pourri," or "Adapting the 'Open-Classroom' to the Teaching of Foreign Languages," (2) "We Can Teach Anyone to Speak French," (3) "The Use of Puppetry in the Teaching of Foreign Languages," (4) "A New Perspective for Integrated Foreign…

  7. Multilingual Thesauri for the Modern World - No Ideal Solution?

    ERIC Educational Resources Information Center

    Jorna, Kerstin; Davies, Sylvie

    2001-01-01

    Discusses thesauri as tools for multilingual information retrieval and cross-cultural communication. Considers the need for multilingual thesauri and the importance of explicit conceptual structures, and introduces a pilot thesaurus, InfoDEFT (Information Deutsch-English-Francais Thesaurus), as a possible model for new online thesauri which are…

  8. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (15th, Quebec, Canada, March 15-16, 2001).

    ERIC Educational Resources Information Center

    Goulet, Marie-Josee, Ed.

    Papers on language research in this volume include the following: "Temporalite en francais de France. Differences dans la conceptualisation du temps et son expression dans un texte narratif oral" ("Differences in the Conceptualization of Time and Its Expression in Oral Narratives") (Natalia Dankova); "La traduction des textes womanist: le cas de…

  9. Discours oraux--discours ecrits: quelles relations? Actes du 4eme colloque d'orthophoine/logopedie (Neuchatel, 3-4 octobre, 1996) (Oral Discourse--Written Discourse: What Is the Relationship? Proceedings of the Colloquium on Speech Therapy (4th, Neuchatel, Switzerland, October 3-4, 1996).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    1996-01-01

    Research papers on the relationship between oral and written language include: "Une distinction bien fragile: oral/ecrit" ("A Fragile Distinction: Oral/Written") (Francoise Gadet); "Oral et ecrit dans les representations des enseignants et dans les pratiques quotidiennes de la classe de francais" ("Oral and Written Language in Teachers'…

  10. Travaux du laboratoire de traitement du langage et de la parole (Laboratory Work in the Treatment of Language and Linguistics).

    ERIC Educational Resources Information Center

    Grosjean, Francois, Ed.

    1994-01-01

    Research papers on language and linguistics include: "Enchainement des mots et acces au lexique en francais" ("Word Order and Lexical Access in French") (Besson); "L'apport de la coarticulation dans la perception de consonnes occlusives et constrictives" ("The Contribution of Coarticulation to the Perception of Occlusive and Constrictive…

  11. Travaux Neuchatelois de Linguistique (TRANEL) (Neuchatel Working Papers in Linguistics), Volume 14.

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.; Rubattel, Christian, Ed.

    1989-01-01

    Three papers in linguistics, all in French, are presented. "La delocutivite lexicale en francais standard: esquisse d'un modele derivationnel" ("Lexical Delocutivity in Standard French: Sketch of a Derivational Model"), by Marc Bonhomme, examines the process by which certain expressions become neologisms. "La terminologie de l'Essai de grammaire…

  12. FDM Video Classe: Modes d'emploi pour la classe (FDM Video Class: Classroom Uses).

    ERIC Educational Resources Information Center

    Beacco, Marcella Di Giura

    1996-01-01

    Content and design of the videotape series FDM Video Classe, produced by the journal "Le francais dans le monde," are described and classroom uses suggested. The materials are from authentic television programs, selected to illustrate aspects of French culture. It is suggested that the teacher also provide students with supporting materials that…

  13. Some Recent French Courses: Kindergarten to Grade 3.

    ERIC Educational Resources Information Center

    Weinrib, Alice

    1976-01-01

    The following courses of study in French at the primary level are described and evaluated: (1) "En Avant" (E. J. Arnold, 1966), (2) "Repondez s'il vous plait" (Copp Clark, 1975), (3) "Pour les Tous Petits" (Carleton Board of Education, 1974), (4) "Dansons la Capucine (Clarke Irwin, 1973), and (5) "Le Francais Partout: Aux Yeux des Petits" (Holt,…

  14. Games for the Foreign Language Classroom.

    ERIC Educational Resources Information Center

    McMillan, Nancy; Madaras, Susan W.

    Two marketing games are described, "Le Marche Francais" and "El Mercado: The Mexican Market Comes to Life in the Spanish Classroom." Both are patterned after a published game entitled "Market: A Simulation Game." The adaptation in each instance relied on simplifying the original game and presenting it in a form understandable to middle school…

  15. En Francasis: A Supplement of Classroom Activities.

    ERIC Educational Resources Information Center

    Enwall, Beverly; Joiner, Elizabeth

    This classroom activity supplement is designed to accompany the "En Francais" language instruction series (programs 1-13) used on closed circuit television in South Carolina. It is intended to enrich classroom follow-up of the film program and to prvide a variety of activities and suggestions for teaching French language skills. Lessons introduce…

  16. Year-One Evaluation of French in the Elementary Schools. Research Report 75-17.

    ERIC Educational Resources Information Center

    Gleadow, N. E.

    During the 1974-1975 school year eight itinerant French teachers travelled among 20 elementary schools teaching oral French to Grade 6 and Grade 7 students. Each teacher was responsible for two or three schools, The course was based on the book Le Francais Partout-Cours Preliminaire (1967) ed.). The study described in this report was initiated to…

  17. From CD-ROM to the WWW: Coming Full Circle.

    ERIC Educational Resources Information Center

    Burston, Jack

    1998-01-01

    Describes the challenges faced and solutions adopted in adapting the multimedia-rich "Varietes de francais" CD-ROM program to operate on the World Wide Web. The program runs locally to retrieve media resources, perform intelligent answer processing and data collection, and turns to the Web only when necessary for data transfer, external Web links,…

  18. Bureau for International Language Coordination (BILC) Bulletin No. 2.

    ERIC Educational Resources Information Center

    Waters, J., Ed.

    This is the second bulletin in a series dealing with international issues in language instruction in the military. Articles include: (1) "L'Enseignement des langues (etrangeres) dans les Forces Armees Belges," (2) "La Morphologic de la Conjugaison ecrite simple en francais contemporain: evantail des cas et rendement des categories," (3) "Data…

  19. Problemes en enseignement fonctionnel des langues (Problems in the Functional Teaching of Languages). Publication B-103.

    ERIC Educational Resources Information Center

    Alvarez, Gerardo, Ed.; Huot, Diane, Ed.

    Articles include: (1) "L'elaboration du materiel pedagogique pour des publics adultes" (The Elaboration of Teaching Materials for the Adult Public) by G. Painchaud-Leblanc, (2) "L'elaboration d'un programme d'etudes en francais langue seconde a partir des donnees recentes en didactique des langues" (The Elaboration of a Program of Study in French…

  20. Bureau for International Language Coordination (BILC) Bulletin No. 5.

    ERIC Educational Resources Information Center

    Collins, K. E., Ed.

    This is the fifth in a continuing series of bulletins dealing with international approaches and problems in language instruction in the military. Articles contained in this volume include: (1) "Connaissez-vous Milivox?"/"Do You Know about Milivox?," (2) "L'Audiomil Francais," (3) "An Attempt at the Construction of a Phonetic Discrimination Test…

  1. Melanges, No. 23.

    ERIC Educational Resources Information Center

    Melanges, 1997

    1997-01-01

    Articles on second language teaching and learning include: "Ethnographie comparee de la salle de classe en France et en grande-Bretagne" (Comparative Ethnography of the Classroom Environment in France and Great Britain) (F. Carton); "Pour une approche micro et macro du francais parle dans la formation des enseignants de FLE" (Toward a Micro and…

  2. Report on a Fulbright Year in France: Toulouse-Le Mirail.

    ERIC Educational Resources Information Center

    Emblidge, David

    1979-01-01

    Describes the experience which seemed to bear out the diagnosis of French history, character, and culture in "Le mal francais" by Peyrefitte. Intra-departmental relationships, the curriculum, course content, student life and attitudes, the physical plant, and the examination system are among the topics discussed. (AMH)

  3. Indexing Price Trends of French Academic Books in the Humanities and Social Sciences.

    ERIC Educational Resources Information Center

    Austin, Ronald E.

    1994-01-01

    Provides data on price trends for French academic books in the humanities and social sciences for the years 1986-90 based on information from the "Bulletin Critique du Livre Francais," a monthly book-reviewing journal. A method for developing a price index for this material is demonstrated. (Contains eight references.) (LRW)

  4. Actes des journees de linguistique: Colloque sur la recherche etudiante (Proceedings of the Linguistics Conference: Colloquium on Student Research) (Quebec, Canada, March 18-19, 1988).

    ERIC Educational Resources Information Center

    Lepage, Danielle, Ed.; Dominik, Annette, Ed.

    Presentations by students at a colloquium on student research on the occasion of the 50th anniversary of the University of Laval's Faculty of Letters, March 18-19, 1988, include: "Une enquete sur la qualite du francais ecrit au Quebec"; "Amenagement linguistique et neologie"; "Analyse syntaxique des 'arrets et retours' en arabe morocain parle";…

  5. French Video Cassettes Produced by the Ecole Commerciale de la Chambre de Commerce et d'Industrie de Paris: Maximizing the Cultural and Linguistic Returns.

    ERIC Educational Resources Information Center

    King, Charlotte P.

    This paper discusses the use of videotapes furnished with the "Valise du Francais des Affaires" from the Chambre de Commerce et d'Industrie de Paris to teach business French. In the videotapes, French employers discuss the type of employee they would like to hire, and the problems they have encountered in some of the interviews they have conducted…

  6. De l'analyse de contextes a la pedagogie des textes (From Analysis of Context to Pedagogy of Texts)

    ERIC Educational Resources Information Center

    Lehmann, Denis

    1976-01-01

    A detailed description of the "Dictionnaire contextual de francais pour la geologie." This study is used as an example of such a dictionary serving as a basic tool in the study of functional French. Such dictionaries can be useful in conceptual approaches to language learning. (Text is in French.) (AMH)

  7. The Combined Use of Radio and Television and Correspondence Courses in Higher Education. (European University and Post-University Distant Study Systems).

    ERIC Educational Resources Information Center

    Lefranc, Robert

    The 1960's witnessed in Europe the development of distant study systems based, to begin with, essentially on radio and/or television together with correspondence courses. In secondary education these included the German Telekolleg and the French RTS Promotion, produced under the auspices of the Office Francais des Techniques Modernes d'Education;…

  8. ENGLISH AS A SECOND LANGUAGE FOR FRENCH-SPEAKING STUDENTS IN SECONDARY SCHOOLS.

    ERIC Educational Resources Information Center

    Ontario Curriculum Inst., Toronto.

    THIS REPORT WAS SUBMITTED IN JULY 1965 BY THE FRANCAIS SUB-COMMITTEE AND THE MODERN LANGUAGE COMMITTEE TO THE ONTARIO CURRICULUM INSTITUTE. THE SUBJECT WAS A SURVEY UNDERTAKEN IN 1964 TO STUDY THE TEACHING OF ENGLISH IN CANADIAN SECONDARY SCHOOLS ATTENDED BY FRENCH-SPEAKING STUDENTS. THE FUNDAMENTAL ISSUE INVOLVED IN THE SECONDARY EDUCATION OF…

  9. The Training of Modern Language Teachers in Various Countries. Collection d'"Etudes linguistiques," No. 20. Selected papers from the Association Internationale pour la Recherche et la Diffusion des Methodes Audio-Visuelles et Structuro-Globales Seminar (5th, August 27-September 1, 1973).

    ERIC Educational Resources Information Center

    Nivette, Jos, Ed.

    Selected papers that address theoretical and practical training of the modern language teacher and language teaching experiments in various countries are presented. Some of the articles included are the following: "Les problemes de la formation linguistique et pedagogique des professeurs de francais en Afrique Subsaharienne" (The Problems of the…

  10. 1975 Textbooks for French Civilization.

    ERIC Educational Resources Information Center

    Brown, Jack Davis

    Four 1975 textbooks for French civilization courses are cited including price, suggested level, format and a listing of contents. A review of one text follows: Rey and Santoni, "Quand les Francais parlent: Langue en contexte, culture en contraste," Newbury House Publishers. The reviewer states that this book is basically a sociological study of…

  11. Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton.

    The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The eight…

  12. Die CREDIF-Methodik. Versuch einer kritischen Bestandsaufnahme (The CREDIF Methodology. An Attempt at a Critical Evaluation)

    ERIC Educational Resources Information Center

    Firges, Jean

    1975-01-01

    A critique of the audiovisual courses of Level 1 produced by the Centre de Recherche et d'Etudes pour la Diffusion du Francais. Discusses the textbook "Bonjour Line" (for 8- to 11-year-olds), "Voix et Images de France" and "De Vive Voix" (both for those older than 11). (Text is in German.) (IFS/WGA)

  13. L'enseignement de la langue maternelle dans les ecoles francaise aujourd'hui (The Teaching of the Native Language in French Schools Today).

    ERIC Educational Resources Information Center

    Marchand, Frank

    1979-01-01

    Describes the three methods of teaching French in elementary schools in France: the traditional, the Freinet, and the "Plan de renovation pour l'enseignement du francais." A description of a model for the l980s is given. Techniques influenced by sociolinguistics seem most suited to replace traditional methodology. (AMH)

  14. Les mammiferes aquatiques: lexique anglais-francais des mammiferes marins actuels ou recemment disparus, y compris les especes d'eau douce des groupes surtout marins (Aquatic Mammals: English-French Glossary of Livinq or Recently Extinct Marine Mammals, Including the Fresh Water Species of Prevalently Marine Groups).

    ERIC Educational Resources Information Center

    Nekrassoff, Vladimir N.

    1980-01-01

    Introduces a new glossary of aquatic mammals representing recent taxonomic revisions. Describes its design, which consists of the glossary proper, listing the scientific name of each entry followed by its English and French equivalents, and of two indexes, listing other common names for the same entries referred back to the scientific term. (MES)

  15. Francais langue seconde: trousse d'evaluation--tests modeles pour les cours: French 31a (Avance 7); French 31b (Avance 8); French 31c (Avance 9) (French as a Second Language: Evaluation Resource Package--Model Tests for the Courses: French 31a (Advanced 7); French 31b (Advanced 8); French 31c (Advanced 9)).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The French as a Second Language model tests for advanced levels 7, 8, and 9 were designed to evaluate students' language performance, as outlined in the program of studies for Alberta, Canada, in listening and reading comprehension and oral and written production, communication skills, culture, language and general language knowledge. The tests…

  16. Tu peux compter sur moi: Guide a l'intention du parent pour l'accompagnement de l'enfant dans son education en francais langue premiere (You Can Count on Me: Guide for Parents for Accompanying Their Child in French as a First Language Education).

    ERIC Educational Resources Information Center

    Federation des parents francophones de l'Alberta, Edmonton (Canada).

    This guidebook is intended for parents of French-speaking students in Alberta. It describes French-as-a-first-language education in Alberta and provides information to help parents, in collaboration with school personnel and the wider francophone community in Alberta, to preserve and develop their children's identity as speakers of French and as…

  17. Speaking Personally--With John Seely Brown

    ERIC Educational Resources Information Center

    American Journal of Distance Education, 2008

    2008-01-01

    This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

  18. (Biotechnology for the conversion of lignocellulosics)

    SciTech Connect

    Woodward, J.

    1990-10-25

    This report summarizes the results of the traveler's participation in the International Energy Agency (IEA) Network planning meeting for Biotechnology for the Conversion of Lignocellulosics,'' held at the Institut Francais du Petrole (IFP), Rueil-Malmaison, France. It also summarizes the results of discussions held at Aston University, Birmingham, UK, with Dr. Martin Beevers with whom the traveler is attempting to initiate a collaborative research project that will be beneficial to ongoing research programs at Oak Ridge National Laboratory (ORNL). The itinerary for the trip is given in Appendix A; the names of the people contacted are listed in Appendix B. Also, pertinent information about the Institut Francais du Petrole is attached (Appendix C). 1 tab.

  19. Dimerize ethylene to butene-1

    SciTech Connect

    Commereuc, D.; Andrews, J.; Chauvin, Y.; Gillard, J.; Leonard, J.

    1984-11-01

    Institut Francais du Petrole (IFP) has developed a new process, Alphabutol, to dimerize selectively ethylene to butene-1. The Alphabutol process uses a homogeneous catalyst which means that reactants, products and catalyst are all soluble in the same liquid phase. The new catalytic system used in the Alphabutol process avoids isomerization of butene-1 to butene-2. Therefore, there is no need for product superfractionation.

  20. How to estimate production cost by steam drive

    SciTech Connect

    Burger, J.; Champlon, D.

    1983-06-01

    The expense of steam flooding, and that of any other enhanced recovery program, can only be justified if the returns are economically attractive. Trying to determine in advance if this is the case can be difficult, but studies at Institut Francais du Petrole make such a determination fairly simple and rapid. The method is based on a theoretical grid system, with each grid having two wells - a producing well and an injection well. Standardized equipment is recommended throughout.

  1. Offshore data base shows decline in rig accidents

    SciTech Connect

    Bertrand, A.; Escoffier, L. )

    1991-09-16

    Institut Francais du Petrole (IFP) has compiled statistical figures on offshore accidents for risk, safety, and reliability studies. IFP calls this data base Platform. It provides a body of essential data for accidents concerning both mobile and stationary offshore drilling rigs. Historical accident data bases are a basic implement for risk assessment of safety and reliability. IFP has built this data base with all available information from 950 actual listings.

  2. Essais d'application d'un cadre de reference pragmatique a la realisation de materiels d'apprentissage du francais langue etrangere. L'Enseignement de la competence de communication en langues secondes. (An Attempt to Apply a Pragmatic Frame of Reference to the Production of Materials for the Study of French as a Second Language). The Teaching of Communicative Competence in Second Languages. Acts of the Colloquim of the Swiss Interuniversity Commission for Applied Linguistics. CILA Bulletin.

    ERIC Educational Resources Information Center

    Richterich, Rene

    Second language learning today requires new materials. One type of learning unit suggested would have a simple format, limited scope and objectives, and diversity of content, form, learning strategies and activities. In spite of the problems involved in the production of this format, such units might be worked out in teacher-training programs, by…

  3. 76 FR 58078 - Thirteenth Meeting: RTCA Special Committee 214: Working Group 78: Standards for Air Traffic Data...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... Parc tertiaire Silic, 3 avenue Charles Lindburg, BP 20351, 94628 RUNGIS Cedex, Paris, France. Confirm... .@eurocontrol.int. FOR FURTHER INFORMATION CONTACT: RTCA Secretariat, 1150 18th Street, NW., Suite...

  4. LNG projects make progress in Oman and Yemen

    SciTech Connect

    1997-02-24

    Two LNG projects in the Middle East, one in Oman and the other in Yemen, are due on stream at the turn of the century--each the largest single project ever put together in its country. Officials described their projects at a yearend 1996 conference in Paris by Institut Francais du Petrole and Petrostrategies. The Oman project develops gas reserves, does gas processing, and transports the gas 360 km to a liquefaction plant to be built on the coast. The Yemen project involves a liquefaction plant and an export terminal.

  5. Downhole frac monitoring system developed

    SciTech Connect

    Sarda, J.P.; Wittrisch, C.; Perreau, P.; Deflandre, J.P.

    1987-04-06

    A hydraulic fracture monitoring system makes it possible to determine the azimuth, length, and height of hydraulic fractures. Institut Francais du Petrole (IFP) has designed, patented, and field tested the system, which is designated Simfrac. It consists of a downhole monitoring tool with real-time surface readout and recording of microseismic events generated during the fracture opening or closing that occurs after the injection of fracture fluids. Combining Simfrac Interpretation with mathematical models can provide a better image of downhole stresses improved hydraulic fracture design, and can indicate optimum drill sites.

  6. Material report in support to RCC-MRX code 2010 stainless steel parts and products

    SciTech Connect

    Ancelet, Olivier; Lebarbe, Thierry; Dubiez-Le Goff, Sophie; Bonne, Dominique; Gelineau, Odile

    2012-07-01

    This paper presents the Material Report dedicated to stainless steels parts and products issued by AFCEN (Association Francaise pour les regles de Conception et de Construction des Materiels des Chaudieres Electro-Nucleaires) in support to RCC-MRx 2010 Code. The RCC-MRx Code is the result of the merger of the RCC-MX 2008, developed in the context of the research reactor Jules Horowitz Reactor project, in the RCC-MR 2007, which set up rules applicable to the design of components operating at high temperature and to the Vacuum Vessel of ITER (a presentation of RCC-MRx 2010 Code is the subject of another paper proposed in this Congress; it explains in particular the status of this Code). This Material Report is part of a set of Criteria of RCC-MRx (this set of Criteria is under construction). The Criteria aim at explaining the design and construction rules of the Code. They cover analyses rules as well as part procurement, welding, methods of tests and examination and fabrication rules. The Material Report particularly provides justifications and explanations on requirements and features dealing with parts and products proposed in the Code. The Material Report contains the following information: Introduction of the grade(s): codes and standards and Reference Procurement Specifications covering parts and products, applications and experience gained, - Physical properties, - Mechanical properties used for design calculations (base metal and welds): basic mechanical properties, creep mechanical properties, irradiated mechanical properties, - Fabrication: experience gained, metallurgy, - Welding: weldability, experience gained during welding and repair procedure qualifications, - Non-destructive examination, - In-service behaviour. In the article, examples of data supplied in the Material Report dedicated to stainless steels will be exposed. (authors)

  7. Application of an Improved Proteomics Method for Abundant Protein Cleanup: Molecular and Genomic Mechanisms Study in Plant Defense*

    PubMed Central

    Zhang, Yixiang; Gao, Peng; Xing, Zhuo; Jin, Shumei; Chen, Zhide; Liu, Lantao; Constantino, Nasie; Wang, Xinwang; Shi, Weibing; Yuan, Joshua S.; Dai, Susie Y.

    2013-01-01

    High abundance proteins like ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) impose a consistent challenge for the whole proteome characterization using shot-gun proteomics. To address this challenge, we developed and evaluated Polyethyleneimine Assisted Rubisco Cleanup (PARC) as a new method by combining both abundant protein removal and fractionation. The new approach was applied to a plant insect interaction study to validate the platform and investigate mechanisms for plant defense against herbivorous insects. Our results indicated that PARC can effectively remove Rubisco, improve the protein identification, and discover almost three times more differentially regulated proteins. The significantly enhanced shot-gun proteomics performance was translated into in-depth proteomic and molecular mechanisms for plant insect interaction, where carbon re-distribution was used to play an essential role. Moreover, the transcriptomic validation also confirmed the reliability of PARC analysis. Finally, functional studies were carried out for two differentially regulated genes as revealed by PARC analysis. Insect resistance was induced by over-expressing either jacalin-like or cupin-like genes in rice. The results further highlighted that PARC can serve as an effective strategy for proteomics analysis and gene discovery. PMID:23943779

  8. Comparison of SERPENT and CASMO-5M for pressurized water reactors models

    SciTech Connect

    Hursin, M.; Vasiliev, A.; Ferroukhi, H.; Pautz, A.

    2013-07-01

    The objective of this work is to perform a preliminary assessment of the capability of SERPENT to generate cross sections for a PWR Beginning-of-Life (BOL) isothermal mini-core by comparing a SERPENT/PARCS solution with the results obtained using a CASMO-5M/PARCS approach. The PARCS code is used instead of the usual SIMULATE-3 to analyze the Swiss Reactors, because interfaces with PARCS already exist to obtain neutronic data from SERPENT. For the PWR configurations, the differences between CASMO-5M and SERPENT solutions are within 200 pcm at the assembly level and thus rather small when considering the deterministic transport method (energy/angular/space discretization) in CASMO-5M versus the stochastic treatment of SERPENT, the statistical uncertainties in the Monte-Carlo approach as well as the eventual differences in nuclear data used by both codes. At the 2D mini-core level, no major difference is observed when comparing PARCS run with CASMO-5M versus SERPENT cross sections. For the generation of kinetic parameters, non trivial differences are observed due both to the methods and the data used. For the relatively limited number of configurations considered, it is hard to make any definitive statement on the benefits of using Monte Carlo codes in terms of nuclear data generation. (authors)

  9. Application of an improved proteomics method for abundant protein cleanup: molecular and genomic mechanisms study in plant defense.

    PubMed

    Zhang, Yixiang; Gao, Peng; Xing, Zhuo; Jin, Shumei; Chen, Zhide; Liu, Lantao; Constantino, Nasie; Wang, Xinwang; Shi, Weibing; Yuan, Joshua S; Dai, Susie Y

    2013-11-01

    High abundance proteins like ribulose-1,5-bisphosphate carboxylase oxygenase (Rubisco) impose a consistent challenge for the whole proteome characterization using shot-gun proteomics. To address this challenge, we developed and evaluated Polyethyleneimine Assisted Rubisco Cleanup (PARC) as a new method by combining both abundant protein removal and fractionation. The new approach was applied to a plant insect interaction study to validate the platform and investigate mechanisms for plant defense against herbivorous insects. Our results indicated that PARC can effectively remove Rubisco, improve the protein identification, and discover almost three times more differentially regulated proteins. The significantly enhanced shot-gun proteomics performance was translated into in-depth proteomic and molecular mechanisms for plant insect interaction, where carbon re-distribution was used to play an essential role. Moreover, the transcriptomic validation also confirmed the reliability of PARC analysis. Finally, functional studies were carried out for two differentially regulated genes as revealed by PARC analysis. Insect resistance was induced by over-expressing either jacalin-like or cupin-like genes in rice. The results further highlighted that PARC can serve as an effective strategy for proteomics analysis and gene discovery.

  10. Thin-layer and full Navier-Stokes calculations for turbulent supersonic flow over a cone at an angle of attack

    NASA Technical Reports Server (NTRS)

    Smith, Crawford F.; Podleski, Steve D.

    1993-01-01

    The proper use of a computational fluid dynamics code requires a good understanding of the particular code being applied. In this report the application of CFL3D, a thin-layer Navier-Stokes code, is compared with the results obtained from PARC3D, a full Navier-Stokes code. In order to gain an understanding of the use of this code, a simple problem was chosen in which several key features of the code could be exercised. The problem chosen is a cone in supersonic flow at an angle of attack. The issues of grid resolution, grid blocking, and multigridding with CFL3D are explored. The use of multigridding resulted in a significant reduction in the computational time required to solve the problem. Solutions obtained are compared with the results using the full Navier-Stokes equations solver PARC3D. The results obtained with the CFL3D code compared well with the PARC3D solutions.

  11. A novel p53-binding domain in CUL7

    SciTech Connect

    Kasper, Jocelyn S.; Arai, Takehiro; De Caprio, James A. . E-mail: james_decaprio@dfci.harvard.edu

    2006-09-15

    CUL7 is a member of the cullin RING ligase family and forms an SCF-like complex with SKP1 and FBXW8. CUL7 is required for normal mouse embryonic development and cellular proliferation, and is highly homologous to PARC, a p53-associated, parkin-like cytoplasmic protein. We determined that CUL7, in a manner similar to PARC, can bind directly to p53 but does not affect p53 expression. We identified a discrete, co-linear domain in CUL7 that is conserved in PARC and HERC2, and is necessary and sufficient for p53-binding. The presence of p53 stabilized expression of this domain and we demonstrate that this p53-binding domain of CUL7 contributes to the cytoplasmic localization of CUL7. The results support the model that p53 plays a role in regulation of CUL7 activity.

  12. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0103191

  13. Primary Atomic Clock Reference System

    NASA Technical Reports Server (NTRS)

    2001-01-01

    An artist's concept of the Primary Atomic Clock Reference System (PARCS) plarned to fly on the International Space Station (ISS). PARCS will make even more accurate atomic time available to everyone, from physicists testing Einstein's Theory of Relativity, to hikers using the Global Positioning System to find their way. In ground-based atomic clocks, lasers are used to cool and nearly stop atoms of cesium whose vibrations are used as the time base. The microgravity of space will allow the atoms to be suspended in the clock rather than circulated in an atomic fountain, as required on Earth. PARCS is being developed by the Jet Propulsion Laboratory with principal investigators at the National Institutes of Standards and Technology and the University of Colorado, Boulder. See also No. 0100120.

  14. The determination of residence times in a pilot plant

    NASA Astrophysics Data System (ADS)

    Ramírez, F. Pablo; Cortés, M. Eugenia

    2004-01-01

    It is well known that residence time distributions (RTD) are very important in many chemical processes such as separation, reforming, hydrocracking, fluid catalytic cracking, hydrodesulfuration, hydrogenation among others [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. In addition, tracers can be used to measure the velocity, distribution and residence time of any stream through any part of an industrial [Guidebook on Radioisotope Tracers in Industry, IAEA, Vienna, 1990] or experimental system. Perhaps the best quality of radiotracers is that they do not interfere with normal unit operations or production scheduling. In this paper are presented the RTDs obtained in a pilot plant for a hydrogenation process [IMP, Technical Report, Determinación del tiempo de residencia promedio en el reactor de la planta piloto de hidroagotamiento de crudo, 2002]. The RTDs show a random phenomenon, which is not typical of this type of chemical processes. Several RTDs were determined in order to confirm this random behavior. The data were obtained using as a tracer a radioactive form of sodium iodide containing iodine-131 [The Condensed Chemical Dictionary, 10th Ed., Van Nostrand Reinhold, USA, 1981]. The process works with two phases in a countercurrent flow, inside a packed column. The liquid phase goes down by gravity. The gas phase goes up due to pressure difference [3 Procédés de transformation, Editions Technip, Institute Francais du Petrole, Paris, France, 1998]. The tracer was selected such that it would follow the liquid phase.

  15. Genetic Characterization of Fluoroquinolone-Resistant Streptococcus pneumoniae Strains Isolated during Ciprofloxacin Therapy from a Patient with Bronchiectasis

    PubMed Central

    de la Campa, Adela G.; Ferrandiz, María-José; Tubau, Fe; Pallarés, Román; Manresa, Federico; Liñares, Josefina

    2003-01-01

    Five Spain9V-3 Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants. PMID:12654682

  16. Analysis of an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1992-01-01

    It is shown that a time marching Navier-Stokes code called PARC can be utilized to provide a reasonable prediction of the flow field within an inlet for an advanced ducted propeller. The code validation was implemented for a nonseparated flow condition associated with the inlet functioning at angles-of-attack of zero and 25 deg. Comparison of the computational results with the test data shows that the PARC code with the propeller face fixed flow properties boundary conditions (BC) provided a better prediction of the inlet surface static pressures than the prediction when the mass flow BC was employed.

  17. Electronic Paper Turns the Page.

    ERIC Educational Resources Information Center

    Mann, Charles C.

    2001-01-01

    Suggests that, rather than the electronic book, the technology that is most likely to transform reading and writing will be electronic paper (e-paper). Traces the evolution of e-paper from its prototype created by Xerox PARC's Nick Sheridon in 1975 to the E Ink/Lucent e-paper made from e-ink and plastic transistors. Highlights future…

  18. Status of Fundamental Physics Program

    NASA Technical Reports Server (NTRS)

    Lee, Mark C.

    2003-01-01

    Update of the Fundamental Physics Program. JEM/EF Slip. 2 years delay. Reduced budget. Community support and advocacy led by Professor Nick Bigelow. Reprogramming led by Fred O Callaghan/JPL team. LTMPF M1 mission (DYNAMX and SUMO). PARCS. Carrier re baselined on JEM/EF.

  19. CHALLENGES FACING HIGH POWER PROTON ACCELERATORS

    SciTech Connect

    Plum, Michael A

    2013-01-01

    This presentation will provide an overview of the challenges of high power proton accelerators such as SNS, J-PARC, etc., and what we have learned from recent experiences. Beam loss mechanisms and methods to mitigate beam loss will also be discussed.

  20. Antimicrobial susceptibility and mechanisms of resistance to quinolones and beta-lactams in Acinetobacter genospecies 3.

    PubMed

    Ribera, A; Fernández-Cuenca, F; Beceiro, A; Bou, G; Martínez-Martínez, L; Pascual, A; Cisneros, J M; Rodríguez-Baño, J; Pachón, J; Vila, J

    2004-04-01

    Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies 3. Moreover, the mechanisms of resistance to some beta-lactam antibiotics may be associated with the presence of a chromosomal cephalosporinase, AmpC, and the resistance to quinolones related to mutations in the gyrA and parC genes.

  1. Antimicrobial Susceptibility and Mechanisms of Resistance to Quinolones and β-Lactams in Acinetobacter Genospecies 3

    PubMed Central

    Ribera, A.; Fernández-Cuenca, F.; Beceiro, A.; Bou, G.; Martínez-Martínez, L.; Pascual, A.; Cisneros, J. M.; Rodríguez-Baño, J.; Pachón, J.; Vila, J.

    2004-01-01

    Antimicrobial susceptibility was determined in 15 epidemiologically unrelated clinical isolates of Acinetobacter genospecies 3. Moreover, the mechanisms of resistance to some β-lactam antibiotics may be associated with the presence of a chromosomal cephalosporinase, AmpC, and the resistance to quinolones related to mutations in the gyrA and parC genes. PMID:15047561

  2. Fluoroquinolone-resistance mechanisms and phylogenetic background of clinical Escherichia coli strains isolated in south-east Poland.

    PubMed

    Korona-Glowniak, Izabela; Skrzypek, Kinga; Siwiec, Radosław; Wrobel, Andrzej; Malm, Anna

    2016-09-01

    Fluorochinolones are a class of broad-spectrum antimicrobials in the treatment of several infections, including those caused by Escherichia coli. Due to the increasing resistance of bacteria to antimicrobials, an understanding of fluoroquinolone resistance is important for infection control. The aim of this study was to determine susceptibility of clinical E. coli strains to fluoroquinolones and characterize their mechanisms of quinolone resistance. Totally, 79 non-duplicate clinical E. coli isolates included in this study were mainly from skin lesion -36 (45.6%) isolates; 54 (68.4%) isolates were assigned to phylogenetic B2 group. Resistance to ciprofloxacin was found in 20 isolates. In the quinolone resistance-determining region (QRDR) region of gyrA and parC, 4 types of point mutations were detected. Mutations in parC gene were found in all strains with gyrA mutations. Predominance of double mutation in codon 83 and 87 of gyrA (90%) and in codon 80 of parC (90%) was found. Moreover, plasmid-mediated quinolone resistance (PMRQ) determinants (qnrA or qnrB and/or aac(6')-Ib-cr) were present in 5 (25%) out of 20 fluoroquinolone-resistant isolates. Resistance to fluoroquinolones in all of the tested clinical E. coli isolates correlated with point mutations in both gyrA and parC. The majority of fluoroquinolone-resistant strains belonged to D and B2 phylogenetic groups. PMID:27602420

  3. Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014–2015

    PubMed Central

    Poramathikul, Kamonporn; Chiek, Sivhour; Oransathid, Wilawan; Ruekit, Sirigade; Nobthai, Panida; Lurchachaiwong, Woradee; Serichantalergs, Oralak; Lon, Chanthap; Swierczewski, Brett

    2016-01-01

    We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrheal surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalosporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, β-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options. PMID:27532684

  4. An electrochemical method for determining hydrogen concentrations in metals and some applications

    NASA Technical Reports Server (NTRS)

    Danford, M. D.

    1983-01-01

    An electrochemical method was developed for the determination of hydrogen in metals using the EG&G-PARC Model 350A Corrosion Measurement Console. The method was applied to hydrogen uptake, both during electrolysis and electroplating, and to studies of hydrogen elimination and the effect of heat treatment on elimination times. Results from these studies are presented.

  5. In Vitro Resistance Development to Nemonoxacin in Streptococcus pneumoniae: A Unique Profile for a Novel Nonfluorinated Quinolone

    PubMed Central

    Roychoudhury, Siddhartha; Makin, Kelly; Twinem, Tracy; Leunk, Robert

    2016-01-01

    Selection of resistant strains in Streptococcus pneumoniae was studied in vitro with nemonoxacin, a novel nonfluorinated quinolone (NFQ), in comparison with quinolone benchmarks, ciprofloxacin, garenoxacin, and gatifloxacin. In stepwise resistance selection studies, a 256-fold loss of potency was observed after three to four steps of exposure to ciprofloxacin or garenoxacin. In contrast, the loss of potency was limited to eightfold after three steps of exposure to nemonoxacin and repeated attempts to isolate highly resistant organisms after four steps of exposure yielded isolates that could not be subcultured in liquid medium. The quinolone resistance-determining regions of the target genes, parC, parE, gyrA, and gyrB, were analyzed through DNA sequencing. Known mutations, especially in the hotspots of parC and gyrA, were selected with exposure to garenoxacin, ciprofloxacin, and gatifloxacin. In contrast, mutations selected with nemonoxacin were limited to GyrA, GyrB, and ParE, sparing ParC, which is known as a key driver of resistance in clinical isolates of S. pneumoniae. This observation is consistent with previous data using other NFQs, which showed no loss of potency due to ParC mutations in clinical isolates. This apparently unique feature of nemonoxacin is potentially attributable to the structural uniqueness of the NFQs, distinguishing them from the fluoroquinolones that are commonly prescribed for infections by S. pneumoniae. PMID:27267788

  6. Plenary.

    ERIC Educational Resources Information Center

    Brown, John Seely

    2000-01-01

    Presents a biography of John Seely Brown, chief scientist of Xerox Corporation and the director of its Palo Alto Research Center (PARC). Interests include formation of corporate strategy; corporate research, including organizational learning, ethnographies of the workplace, and complex adaptive systems; and human learning and the management of…

  7. Hadron Structure with Dimuon Production

    SciTech Connect

    Peng, J. C.

    2008-10-13

    Dimuon production has been studied in a series of fixed-target experiments at Fermilab during the last two decades. Highlights from these experiments, together wih recent results from the Fermilab E866 experiment, are presented. Future prospects for studying the parton distributions in the nucleons and nuclei using dimuon production at Fermilab and J-PARC are also discussed.

  8. Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.

    PubMed

    Poramathikul, Kamonporn; Bodhidatta, Ladaporn; Chiek, Sivhour; Oransathid, Wilawan; Ruekit, Sirigade; Nobthai, Panida; Lurchachaiwong, Woradee; Serichantalergs, Oralak; Lon, Chanthap; Swierczewski, Brett

    2016-09-01

    We observed multidrug resistance in 10 (91%) of 11 Shigella isolates from a diarrheal surveillance study in Cambodia. One isolate was resistant to fluoroquinolones and cephalosporins and showed decreased susceptibility to azithromycin. We found mutations in gyrA, parC, β-lactamase, and mphA genes. Multidrug resistance increases concern about shigellosis treatment options. PMID:27532684

  9. 'Stolo' Strawberry

    Technology Transfer Automated Retrieval System (TEKTRAN)

    ‘Stolo’ is a new June-bearing strawberry (Fragaria x ananassa Duchesne ex Rozier) cultivar from the Agriculture and Agri-Food Canada (AAFC), Pacific Agri-Food Research Center (PARC) in Agassiz, released in cooperation with the B.C. Ministry of Agriculture, Fisheries and Food, U.S. Department of Agri...

  10. Disease management index of potential years of life lost as a tool for setting priorities in national disease control using OECD health data.

    PubMed

    Jang, Sung-In; Nam, Jung-Mo; Choi, Jongwon; Park, Eun-Cheol

    2014-03-01

    Limited healthcare resources make it necessary to maximize efficiency in disease management at the country level by priority-setting according to disease burden. To make the best priority settings, it is necessary to measure health status and have standards for its judgment, as well as consider disease management trends among nations. We used 17 International Classification of Diseases (ICD) categories of potential years of life lost (YPLL) from Organization for Economic Co-operation and Development (OECD) health data for 2012, 37 disease diagnoses YPLL from OECD health data for 2009 across 22 countries and disability-adjusted life years (DALY) from the World Health Organization (WHO). We set a range of 1-1 for each YPLL per disease in a nation (position value for relative comparison, PARC). Changes over 5 years were also accounted for in this disease management index (disease management index, DMI). In terms of ICD categories, the DMI indicated specific areas for priority setting for different countries with regard to managing disease treatment and diagnosis. Our study suggests that DMI is a realistic index that reflects trend changes over the past 5 years to the present state, and PARC is an easy index for identifying relative status. Moreover, unlike existing indices, DMI and PARC make it easy to conduct multiple comparisons among countries and diseases. DMI and PARC are therefore useful tools for policy implications and for future studies incorporating them and other existing indexes.

  11. High Power Proton Facilities

    NASA Astrophysics Data System (ADS)

    Nagaitsev, Sergei

    2015-04-01

    This presentation will provide an overview of the capabilities and challenges of high intensity proton accelerators, such as J-PARC, Fermilab MI, SNS, ISIS, PSI, ESS (in the future) and others. The presentation will focus on lessons learned, new concepts, beam loss mechanisms and methods to mitigate them.

  12. Increasingly automated procedure acquisition in dynamic systems

    NASA Technical Reports Server (NTRS)

    Mathe, Nathalie; Kedar, Smadar

    1992-01-01

    Procedures are widely used by operators for controlling complex dynamic systems. Currently, most development of such procedures is done manually, consuming a large amount of paper, time, and manpower in the process. While automated knowledge acquisition is an active field of research, not much attention has been paid to the problem of computer-assisted acquisition and refinement of complex procedures for dynamic systems. The Procedure Acquisition for Reactive Control Assistant (PARC), which is designed to assist users in more systematically and automatically encoding and refining complex procedures. PARC is able to elicit knowledge interactively from the user during operation of the dynamic system. We categorize procedure refinement into two stages: diagnosis - diagnose the failure and choose a repair - and repair - plan and perform the repair. The basic approach taken in PARC is to assist the user in all steps of this process by providing increased levels of assistance with layered tools. We illustrate the operation of PARC in refining procedures for the control of a robot arm.

  13. COMET and PRISM - Search for Charged Lepton Flavor Violation with Muons

    NASA Astrophysics Data System (ADS)

    Kuno, Yoshitaka

    2012-04-01

    The experiment (COMET) at J-PARC to search for a charged-lepton-flavor-violating process of muon to electron conversion in a muonic atom is described. Future prospects of an experiment (PRISM) with even higher sensitivity is mentioned. On-going R&D on a highly intense muon source (MuSIC) at Osaka University is presented.

  14. Technology development for laser-cooled clocks on the International Space Station

    NASA Technical Reports Server (NTRS)

    Klipstein, W. M.

    2003-01-01

    The PARCS experiment will use a laser-cooled cesium atomic clock operating in the microgravity environment aboard the International Space Station to provide both advanced tests of gravitational theory to demonstrate a new cold-atom clock technology for space.

  15. Transmutation of Long-Lived Nuclear Wastes

    NASA Astrophysics Data System (ADS)

    Oigawa, Hiroyuki

    JAEA is conducting research and development on an Accelerator Driven System (ADS), aiming at reduction of burden for high-level radioactive wastes. To tackle technical challenges on ADS, JAEA is planning to build the Transmutation Experimental Facility as the Phase-2 program of J-PARC. Moreover, JAEA is considering the collaboration with the MYRRHA project proposed by Belgian Nuclear Research Center.

  16. Genetic characterization of fluoroquinolone-resistant Escherichia coli associated with bovine mastitis in India

    PubMed Central

    Balakrishnan, Sangeetha; Antony, Prabhakar Xavier; Mukhopadhyay, Hirak Kumar; Pillai, Raghavan Madhusoodanan; Thanislass, Jacob; Padmanaban, Vijayalakshmi; Srinivas, Mouttou Vivek

    2016-01-01

    Aim: The present study was undertaken to characterize the mutation in gyrA (DNA gyrase) and parC (topoisomerase IV) genes responsible for fluoroquinolone resistance in Escherichia coli isolates associated with the bovine mastitis. Materials and Methods: A total of 92 milk samples from bovine mastitis cases were sampled in and around Puducherry (Southern India). Among these samples, 30 isolates were bacteriologically characterized as E. coli. Minimum inhibitory concentrations (MIC) of fluoroquinolones of these 30 E. coli isolates were evaluated by resazurin microtiter assay. Then, the quinolone resistance determining region (QRDR) (gyrA and parC genes) of these E. coli isolates was genetically analyzed for determining the chromosomal mutation causing fluoroquinolone resistance. Results: E. coli isolates showed a resistance rate of 63.33%, 23.33% and 30.03% to nalidixic acid, ciprofloxacin and enrofloxacin, respectively. Mutations were found at 83rd and 87th amino acid position of gyrA gene, and at 80th and 108th amino acid position of parC gene in our study isolates. Among these five isolates, one had a single mutation at 83 amino acid position of gyrA with reduced susceptibility (0.5 µg/ml) to ciprofloxacin. Then, in remaining four isolates, three isolates showed triple mutation (at gyrA: S83⟶L and D87⟶N; at parC: S80⟶I) and the fifth isolate showed an additional mutation at codon 108 of parC (A108⟶T) with the increased ciprofloxacin MIC of 16-128 µg/ml. The most common mutation noticed were at S83⟶L and D87⟶N of gyrA and S80⟶I of ParC. Conclusion: The study confirms the presence of mutation/s responsible for fluoroquinolone resistance in QRDR of gyrA and parC genes of E. coli isolates of animal origin, and there is increased rate of fluoroquinolone resistance with high-level of MIC. The mutations observed in this study were similar to that of human isolates. PMID:27536030

  17. Analysis of an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1992-01-01

    A time marching Navier-Stokes code called PARC (PARC2D for 2-D/axisymmetric and PARC3D for 3-D flow simulations) was validated for an advanced ducted propeller (ADP) subsonic inlet. The code validation for an advanced ducted propeller (ADP) subsonic inlet. The code validation was implemented for a non-separated flow condition associated with the inlet operating at angles-of-attack of 0 and 25 degrees. The inlet test data were obtained in the 9 x 15 ft Low Speed Wind Tunnel at NASA Lewis Research Center as part of a cooperative study with Pratt and Whitney. The experimental study focused on the ADP inlet performance for take-off and approach conditions. The inlet was tested at a free stream Mach number of 0.2, at angles-of-attack between O and 35 degrees, and at a maximum propeller speed of 12,000 RPM which induced a corrected air flow rate of about 46 lb/sec based on standard day conditions. The computational grid and flow boundary conditions (BC) were based on the actual inlet geometry and the funnel flow conditions. At the propeller face, two types of BC's were applied: a mass flow BC and a fixed flow properties BC. The fixed flow properties BC was based on a combination of data obtained from the experiment and calculations using a potential flow code. Comparison of the computational results with the test data indicates that the PARC code with the propeller face fixed flow properties BC provided a better prediction of the inlet surface static pressures than the predictions when the mass flow BC was used. For an angle-of-attack of 0 degrees, the PARC2D code with the propeller face mass flow BC provided a good prediction of inlet static pressures except in the region of high pressure gradient. With the propeller face fixed flow properties BC, the PARC2D code provided a good prediction of the inlet static pressures. For an angle-of-attack of 25 degrees with the mass flow BC, the PARC3D code predicted statis pressures which deviated significantly from the test data

  18. Internally directed cognition and mindfulness: an integrative perspective derived from predictive and reactive control systems theory

    PubMed Central

    Tops, Mattie; Boksem, Maarten A. S.; Quirin, Markus; IJzerman, Hans; Koole, Sander L.

    2013-01-01

    In the present paper, we will apply the predictive and reactive control systems (PARCS) theory as a framework that integrates competing theories of neural substrates of awareness by describing the “default mode network” (DMN) and anterior insula (AI) as parts of two different behavioral and homeostatic control systems. The DMN, a network that becomes active at rest when there is no external stimulation or task to perform, has been implicated in self-reflective awareness and prospection. By contrast, the AI is associated with awareness and task-related attention. This has led to competing theories stressing the role of the DMN in self-awareness vs. the role of interoceptive and emotional information integration in the AI in awareness of the emotional moment. In PARCS, the respective functions of the DMN and AI in a specific control system explains their association with different qualities of awareness, and how mental states can shift from one state (e.g., prospective self-reflection) to the other (e.g., awareness of the emotional moment) depending on the relative dominance of control systems. These shifts between reactive and predictive control are part of processes that enable the intake of novel information, integration of this novel information within existing knowledge structures, and the creation of a continuous personal context in which novel information can be integrated and understood. As such, PARCS can explain key characteristics of mental states, such as their temporal and spatial focus (e.g., a focus on the here and now vs. the future; a first person vs. a third person perspective). PARCS further relates mental states to brain states and functions, such as activation of the DMN or hemispheric asymmetry in frontal cortical functions. Together, PARCS deepens the understanding of a broad range of mental states, including mindfulness, mind wandering, rumination, autobiographical memory, imagery, and the experience of self. PMID:24904455

  19. Remote-controlled bent sub aids directional drilling by allowing bend-angle change

    SciTech Connect

    Bardin, C.A.

    1989-01-30

    A remotely controlled bent sub has proved its usefulness and efficiency in drilling extended buildups (including drilling out cement and vertical trajectories) as well as in correction runs. The bent sub, T3000 Telepilote, was developed jointly by IFP (Institut Francais du Petrole) and SMFI (Societe Materiel de Forage International). The advantages of this tool range from the bend angles that can be remotely controlled from the surface and by the remote-control system itself. This system is compatible with all equipment in the drillstring, and in particular with MWD tools (positive mud pulse, negative mud pulse, etc.). One main advantage is that the zero position (straight configuration) of the bent sub allows continuous drilling without tripping in between drilling out cement and the vertical section, if any, and drilling the kickoff and buildup.

  20. Methanol gas-treating scheme offers economics, versatility

    SciTech Connect

    Minkkinen, A.; Larue, J.Y. ); Patel, S. ); Levier, J.F. )

    1992-06-01

    This paper reports on a process that has been developed by Institut Francais du Petrole (IFP) to treat natural-gas using methanol as a single, basic solvent to dehydrate, control dew point, recover hydrocarbon liquids, and sweeten produced gas. The impetus for IFP's research and developmental efforts which began in 1986 was to integrate the functional process steps - dehydration, NGL extraction, and acid-gas removal - into a compact solvent process with which water, NGL, and acid gases could be extracted with only a single solvent. Pilot testing and detailed evaluation of Ifpexol with competitive technologies indicated that it exhibits low thermal-energy requirements, has no vent emissions, and allows recovery of process water. Petro-Canada has agreed to collaborate with IFP by installing the first industrial application at its East Gilby gas plant in Alberta.

  1. Global refining beyond the year 2000 - A European perspective

    SciTech Connect

    Gonzalez, R.G.

    1996-01-01

    A new French publication from Editions Technip contains a broad-based discussion on the economic and processing parameters that will shape the refinery of the future. Process experts from Institut Francais Du Petrole (IFP) have constructed a {open_quotes}road map{close_quotes} for refining and petrochemical flow schemes that should interest industry planners and decision makers throughout the world. The importance attributed to the characterization of crude oils and petroleum products is stressed. On a directional basis, the industry will see more emphasis on methodologies to improve existing conversion and separation processes. Buzzwords such as biorefining, refinery integrated information systems, petrochemical/refinery integration and many others will find a forum in future publications.

  2. IFP offers three new process technologies

    SciTech Connect

    Not Available

    1992-11-23

    Institut Francais du Petrole is offering three new processing technologies for license, including one for isomerizing normal C[sub 4] olefins to isobutylene. The latter process, called ISO-4, provides an economically attractive way for refiners and ethylene manufacturers to convert fluid cat cracker and steam cracker C[sub 4] cuts to methyl tertiary butyl ether, says IFP. In ISO-4 units, the catalyst moves continuously down the reactor bed. When it reaches the bottom, it is removed from the reactor, regenerated, and returned to the top of the bed, all continuously. With a constant flow of fresh catalyst, operations can run several years without shutdown for catalyst regeneration, IFP claims. The ISO-4 catalyst is the same type as that used in IFP's octanizing process. The low attrition rate and thorough, continuous regeneration cycle of the Octanizing catalyst result in long service.

  3. C/sub 1/-C/sub 6/ Alcohols from syngas

    SciTech Connect

    Courty, P.; Arile, J.P.; Convers, A.; Mikitenki, P.; Sugler, A.

    1984-11-01

    Alcohol synthesis is a favorable way to upgrade syngas because of: positive thermodynamics, low yield of byproducts and economics. Besides alcohol production for petrochemical uses, a second use has begun: the development of a competitive process for the production of C/sub 1/-C/sub 6/ alcohol mixture, suitable as motor fuel blending component. Methanol is easily produced from syngas but its use as a single gasoline blend component has weaknesses. The two major problems-water-rich phase separation and vapor lock tendencies-can be alleviated by incorporating a cosolvent into the methanol-gasoline blend. The Institut Francais du Petrole (I.F.P.) process produces methanol-heavier alcohols mixture directly suitable for gasoline blending. Previous results/sup 1/ show that a mixture of 15-20 wt% C/sub 2/+ alcohols and 80-85% methanol is adequate to avoid separation under French climatic conditions.

  4. C/sub 1/C/sub 6/ alcohols from syngas

    SciTech Connect

    Courty, Ph.; Arlie, J.P.; Convers, A.; Mikitenko, P.; Sugier, A.

    1984-11-01

    Alcohol synthesis is a favorable way to upgrade syngas because of: positive thermodynamics, low yield of by-products and economics. Besides alcohol production for petrochemical uses, a second use has begun: the development of a competitive process for the production of C/sub 1/-C/sub 6/ alcohol mixture, suitable as motor fuel blending component. Methanol is easily produced from syngas but its use as a single gasoline blend component has weaknesses. The two major problems - water-rich phase separation and vapor lock tendencies - can be alleviated by incorporating a cosolvent into the methanol-gasoline blend. The Institut Francais du Petrole (I.F.P.) process produces methanol-heavier alcohols mixture directly suitable for gasoline blending. Previous results show that a mixture of 15-20 weight % C/sub 2/+ alcohols and 80-85% methanol is adequate to avoid separation under French climatic conditions.

  5. Three years' experience with the offshore self-boring pressuremeter ''PAM''

    SciTech Connect

    Brucy, F.; Fay, J.B.; LeTirant, P.

    1984-05-01

    The Offshore Self-Boring Pressuremeter (PAM) has been developed by the Institut Francais du Petrole for geotechnical investigations in water depths up to 1000 meters. The PAM was first presented at the 1981 OTC. It mainly consists of a seabed frame from which a self-boring pressuremeter probe is operated. To date, the PAM has totaled nearly 450 meters of borehole depth and more than 200 pressuremeter tests. Investigations have been performed in a wide variety of soil types. The latest deepwater campaign was carried out successfully in the Mediterranean at a water depth of 625 meters. Extensive geotechnical information is obtained from a PAM boring operation. The use of the pressuremeter method for offshore investigations and foundation designing should open up very interesting prospects.

  6. Parallel acoustic wave propagation and generation of a seismic dataset

    SciTech Connect

    Oldfield, R.; Dyke, J.V.; Semeraro, B.D.

    1995-12-01

    The ultimate goal of this work is to construct a large seismic dataset that will be used to calibrate industrial seismic analysis codes. Seismic analysis is used in oil and gas exploration to deduce subterranean geological formations based on the reflection of acoustic waves from a source to an array of receivers placed on or near the surface. This work deals with the generation of a test set of acoustic data based on a known representative geological formation. Industrial users of the data will calibrate their codes by comparing their predicted geology to the know geology used to generate the test data. This is a cooperative effort involving Los Alamos, Sandia, Oak Ridge and Lawrence Livermore national labs as well as Institut Francais du Petrole and the Society of Exploration Geophysicists.

  7. Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis

    PubMed Central

    El-Asrar, A M Abu; Struyf, S; Al-Kharashi, S A; Missotten, L; Van Damme, J; Geboes, K

    2002-01-01

    Background/aims: T lymphocytes are present in increased numbers in the conjunctiva of patients with vernal keratoconjunctivitis (VKC) and their activation has a central role in the pathogenesis of the chronic allergic inflammatory reactions seen in VKC. The aims of this study were to examine the expression of three recently described potent T lymphocyte chemoattractants, PARC (pulmonary and activation regulated chemokine), macrophage derived chemokine (MDC), and I-309, the MDC receptor CCR4, and T lymphocyte activation markers, CD25, CD26, CD62L, CD71, and CD30, and to correlate them with the counts of CD3+ T lymphocytes in the conjunctiva of patients with VKC. Method: Conjunctival biopsy specimens from 11 patients with active VKC, and eight control subjects were studied by immunohistochemical techniques using a panel of monoclonal and polyclonal antibodies directed against PARC, MDC, I-309, CCR4, CD25, CD26, CD62L, CD71, and CD30. The numbers of positively stained cells were counted. The phenotype of inflammatory cells expressing chemokines was examined by double immunohistochemistry. Results: In the normal conjunctiva, vascular endothelial cells in the upper substantia propria showed weak immunoreactivity for CD26. There was no immunoreactivity for the other antibodies. VKC specimens showed inflammatory cells expressing PARC, MDC, and I-309. The numbers of PARC+ inflammatory cells were higher than the numbers of MDC+ and I-309+ inflammatory cells and the mean values of the three groups differed significantly (17.0 (SD 10.1); 9.5 (9.9), and 4.3 (7.9), respectively, p = 0.0117, ANOVA). The numbers of PARC+ inflammatory cells had the strongest correlation with the numbers of CD3+ T lymphocytes. Few CCR4+ inflammatory cells were observed in only three specimens. Double immunohistochemistry revealed that all inflammatory cells expressing chemokines were CD68+ monocytes/macrophages. The numbers of CD25+ T lymphocytes were higher than the numbers of CD26+, CD62L+, CD71

  8. Partners in amphibian and reptile conservation 2013 annual report

    USGS Publications Warehouse

    Conrad, Paulette M.; Weir, Linda A.; Nanjappa, Priya

    2014-01-01

    Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effect from overexploitation; these animals are also challenged by the perception that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural an cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation of these animals has never been more important.

  9. Associations of macrolide and fluoroquinolone resistance with molecular typing in Streptococcus pyogenes from invasive infections, 2010-2012.

    PubMed

    Wajima, Takeaki; Morozumi, Miyuki; Chiba, Naoko; Shouji, Michi; Iwata, Satoshi; Sakata, Hiroshi; Ubukata, Kimiko

    2013-11-01

    In this study, the relationship between emm type and antibiotic resistance in 283 invasive group A streptococcal strains collected during surveillance from 2010 to 2012 was analysed. Strains were characterised by emm typing, multilocus sequence typing and antimicrobial susceptibility. Resistance rates for macrolide antibiotics conferred by mef(A), erm(A) or erm(B) were high (54.4%). The most prevalent (40.3%) macrolide resistance mediated by mef(A) was present in 92.2% of emm1 strains. It was found that 53.3% of emm12 strains and 91.7% of emm28 strains had erm(A) or erm(B) genes. Intermediate resistance to fluoroquinolones caused by a mutation in parC was found in 14.1% of strains. Furthermore, three strains (1.1%) with high resistance caused by mutations in both parC and gyrA were detected. Fluoroquinolone resistance was present in various emm types.

  10. High-Precision Microwave Spectroscopy of Muonium for Determination of Muonic Magnetic Moment

    NASA Astrophysics Data System (ADS)

    Torii, H. A.; Higashi, Y.; Higuchi, T.; Matsuda, Y.; Mizutani, T.; Tajima, M.; Tanaka, K. S.; Ueno, Y.; Fukao, Y.; Iinuma, H.; Ikedo, Y.; Kadono, R.; Kawamura, N.; Koda, A.; Kojima, K. M.; Mibe, T.; Miyake, Y.; Nagamine, K.; Nishiyama, K.; Ogitsu, T.; Okubo, R.; Saito, N.; Sasaki, K.; Shimomura, K.; Strasser, P.; Sugano, M.; Toyoda, A.; Ueno, K.; Yamamoto, A.; Yoshida, M.; Ishida, K.; Iwasaki, M.; Kamigaito, O.; Tomono, D.; Kanda, S.; Kubo, K.; Aoki, M.; Torikai, E.; Kawall, D.

    2016-02-01

    The muonium atom is a system suitable for precision measurements for determination of muon’s fundamental properties as well as for the test of quantum electrodynamics (QED). A microwave spectroscopy experiment of this exotic atom is being prepared at J-PARC, jointly operated by KEK and JAEA in Japan, aiming at an improved relative precision at a level of 10-8 in determination of the muonic magnetic moment. A major improvement of statistical uncertainty is expected with the higher muon intensity of the pulsed beam at J-PARC, while reduction of various sources of systematic uncertainties are being studied: those arising from microwave power fluctuations, magnetic field inhomogeneity, muon stopping distribution and atomic collisional shift of resonance frequencies. Experimental strategy and methods are presented in this paper, with an emphasis on our recent development of apparatuses and evaluation of systematic uncertainties.

  11. Flow studies in close-coupled ventral nozzles for STOVL aircraft

    NASA Technical Reports Server (NTRS)

    Mcardle, Jack G.; Smith, C. Frederic

    1990-01-01

    Flow in a generic ventral nozzle system was studied experimentally and analytically with the PARC3D computational fluid dynamics program in order to evaluate the program's ability to predict system performance and internal flow patterns. A generic model of a tailpipe with a rectangular ventral nozzle, about 1/3 of full size, was tested with unheated air at steady state pressure ratios up to 4.0. The end of the tailpipe was closed to simulate a blocked exhaust nozzle. Flow behavior into and through the ventral duct is discussed and illustrated with paint streak flow visualization photographs. PARC3D graphic images are shown for comparison with the experimental photographs. The program successfully predicted internal flow patterns; it also computed thrust and discharge coefficients within 1 pct. of measured values.

  12. Three-dimensional compressible jet-in-crossflow calculations using improved viscosity models and adapted grid

    NASA Technical Reports Server (NTRS)

    Lytle, John K.; Harloff, Gary J.; Hsu, Andrew T.

    1990-01-01

    Previous calculations of jet-in-crossflow problems have been sensitive to the turbulence and artificial viscosity models and to the grid. Consequently, the eddy viscosity model in the PARC3D code was modified to consider the turbulent jet by switching from the Baldwin-Lomax (1978) model to an axisymmetric jet model. A modified artificial viscosity model has been utilized and evaluated in this study as well. The new model includes cell size scaling and a directional dependence in the coefficients. Computational results from PARC3D demonstrate the effects of the viscosity models on the pressure distribution fore and aft of the jet and the ability of the adaptive grid scheme to adjust to the three-dimensional gradients around the jet.

  13. Palo Alto Research Center - Smart Embedded Network of Sensors with an Optical Readout

    ScienceCinema

    Raghavan, Ajay; Sahu, Saroj; Bringans, Ross; Johnson, Noble; Kiesel, Peter; Saha, Bhaskar

    2016-07-12

    PARC is developing new fiber optic sensors that would be embedded into batteries to monitor and measure key internal parameters during charge and discharge cycles. Two significant problems with today's best batteries are their lack of internal monitoring capabilities and their design oversizing. The lack of monitoring interferes with the ability to identify and manage performance or safety issues as they arise, which are presently managed by very conservative design oversizing and protection approaches that result in cost inefficiencies. PARC's design combines low-cost, embedded optical battery sensors and smart algorithms to overcome challenges faced by today's best battery management systems. These advanced fiber optic sensing technologies have the potential to dramatically improve the safety, performance, and life-time of energy storage systems.

  14. Covariance Matrix Adaptation Evolutionary Strategy for Drift Correction of Electronic Nose Data

    NASA Astrophysics Data System (ADS)

    Di Carlo, S.; Falasconi, M.; Sanchez, E.; Sberveglieri, G.; Scionti, A.; Squillero, G.; Tonda, A.

    2011-09-01

    Electronic Noses (ENs) might represent a simple, fast, high sample throughput and economic alternative to conventional analytical instruments [1]. However, gas sensors drift still limits the EN adoption in real industrial setups due to high recalibration effort and cost [2]. In fact, pattern recognition (PaRC) models built in the training phase become useless after a period of time, in some cases a few weeks. Although algorithms to mitigate the drift date back to the early 90 this is still a challenging issue for the chemical sensor community [3]. Among other approaches, adaptive drift correction methods adjust the PaRC model in parallel with data acquisition without need of periodic calibration. Self-Organizing Maps (SOMs) [4] and Adaptive Resonance Theory (ART) networks [5] have been already tested in the past with fair success. This paper presents and discusses an original methodology based on a Covariance Matrix Adaptation Evolution Strategy (CMA-ES) [6], suited for stochastic optimization of complex problems.

  15. Transient Safety Analysis of Fast Spectrum TRU Burning LWRs with Internal Blankets

    SciTech Connect

    Downar, Thomas; Zazimi, Mujid; Hill, Bob

    2015-01-31

    The objective of this proposal was to perform a detailed transient safety analysis of the Resource-Renewable BWR (RBWR) core designs using the U.S. NRC TRACE/PARCS code system. This project involved the same joint team that has performed the RBWR design evaluation for EPRI and therefore be able to leverage that previous work. And because of their extensive experience with fast spectrum reactors and parfait core designs, ANL was also part the project team. The principal outcome of this project was the development of a state-of-the-art transient analysis capability for GEN-IV reactors based on Monte Carlo generated cross sections and the US NRC coupled code system TRACE/PARCS, and a state-of-the-art coupled code assessment of the transient safety performance of the RBWR.

  16. Palo Alto Research Center - Smart Embedded Network of Sensors with an Optical Readout

    SciTech Connect

    Raghavan, Ajay; Sahu, Saroj; Bringans, Ross; Johnson, Noble; Kiesel, Peter; Saha, Bhaskar

    2014-03-07

    PARC is developing new fiber optic sensors that would be embedded into batteries to monitor and measure key internal parameters during charge and discharge cycles. Two significant problems with today's best batteries are their lack of internal monitoring capabilities and their design oversizing. The lack of monitoring interferes with the ability to identify and manage performance or safety issues as they arise, which are presently managed by very conservative design oversizing and protection approaches that result in cost inefficiencies. PARC's design combines low-cost, embedded optical battery sensors and smart algorithms to overcome challenges faced by today's best battery management systems. These advanced fiber optic sensing technologies have the potential to dramatically improve the safety, performance, and life-time of energy storage systems.

  17. Modification of the Two-equation Turbulence Model in NPARC to a Chien Low Reynolds Number K-epsilon Formulation

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.; Chitsomboon, Tawit; Zhu, Jiang

    1994-01-01

    This report documents the changes that were made to the two-equation k-epsilon turbulence model in the NPARC (National-PARC) code. The previous model based on the low Reynolds number model of Speziale, was replaced with the low Reynolds number k-epsilon model of Chien. The most significant difference was in the turbulent Prandtl numbers appearing in the diffusion terms of the k and epsilon transport equations. A new inflow boundary condition and stability enhancements were also implemented into the turbulence model within NPARC. The report provides the rationale for making the change to the Chien model, code modifications required, and comparisons of the performances of the new model with the previous k-epsilon model and algebraic models used most often in PARC/NPARC. The comparisons show that the Chien k-epsilon model installed here improves the capability of NPARC to calculate turbulent flows.

  18. From the "Phoenix of Legends" to the "Ultimate Monument" of the times: stadia, spectators, and urban development in postwar Paris.

    PubMed

    Lewis, Robert W

    2012-01-01

    This article analyzes the renovation and construction of the Parc des Princes and the Stade de France in post-Second World War Paris. The history of the two stadia testifies to a shift in the envisioned role of stadia in the Parisian basin between the late 1960s and the end of the twentieth century and stands as evidence for the emergence of new urban planning actors. Both stadia were also critiqued as symbols of broader problems with Parisian urbanization, notably as manifestations of anti-democratic planning processes. At the same time, the Parc and the Stade also reflected an emerging consensus over the role of spectator sport in society, accompanied by attempts to re-envision mass sporting spectatorship as a more democratic and familial practice. This article thus situates the two stadia within the history of Parisian urbanization and within broader global urbanizing processes.

  19. QX MAN: Q and X file manipulation

    NASA Technical Reports Server (NTRS)

    Krein, Mark A.

    1992-01-01

    QX MAN is a grid and solution file manipulation program written primarily for the PARC code and the GRIDGEN family of grid generation codes. QX MAN combines many of the features frequently encountered in grid generation, grid refinement, the setting-up of initial conditions, and post processing. QX MAN allows the user to manipulate single block and multi-block grids (and their accompanying solution files) by splitting, concatenating, rotating, translating, re-scaling, and stripping or adding points. In addition, QX MAN can be used to generate an initial solution file for the PARC code. The code was written to provide several formats for input and output in order for it to be useful in a broad spectrum of applications.

  20. La Ruta de los Origenes stops in Montsec: observations and other educational activities

    NASA Astrophysics Data System (ADS)

    Ribas, S. J.

    2013-05-01

    La Ruta de los Origenes is an European Cooperation Project POCTEFA funded by FEDER- UE. The main objective of this project is to establish a touristic route on both sides of the Pyrenees to approach Origins topic to the public. This project is developed by six partners, three in Catalonia and three in Midi-Pyrenees, and is focused in Astronomy, Paleontology and Archaelogy. Montsec mountains are placed in the Pre-Pyrenees area of Lleida province and they are a very good place for astronomy (dark skies, good seeing, good weather conditions). Parc Astronomic Montsec is the major astronomy project in that area and it includes a research astronomical observatory and an outreach and education center. So Montsec mountains and their Parc Astronomic are one of the stops of this route with an important number of activities to approach astronomy to public.

  1. The T2K experiment

    NASA Astrophysics Data System (ADS)

    Abe, K.; Abgrall, N.; Aihara, H.; Ajima, Y.; Albert, J. B.; Allan, D.; Amaudruz, P.-A.; Andreopoulos, C.; Andrieu, B.; Anerella, M. D.; Angelsen, C.; Aoki, S.; Araoka, O.; Argyriades, J.; Ariga, A.; Ariga, T.; Assylbekov, S.; de André, J. P. A. M.; Autiero, D.; Badertscher, A.; Ballester, O.; Barbi, M.; Barker, G. J.; Baron, P.; Barr, G.; Bartoszek, L.; Batkiewicz, M.; Bay, F.; Bentham, S.; Berardi, V.; Berger, B. E.; Berns, H.; Bertram, I.; Besnier, M.; Beucher, J.; Beznosko, D.; Bhadra, S.; Birney, P.; Bishop, D.; Blackmore, E.; Blaszczyk, F. d. M.; Blocki, J.; Blondel, A.; Bodek, A.; Bojechko, C.; Bouchez, J.; Boussuge, T.; Boyd, S. B.; Boyer, M.; Braam, N.; Bradford, R.; Bravar, A.; Briggs, K.; Brinson, J. D.; Bronner, C.; Brook-Roberge, D. G.; Bryant, M.; Buchanan, N.; Budd, H.; Cadabeschi, M.; Calland, R. G.; Calvet, D.; Caravaca Rodríguez, J.; Carroll, J.; Cartwright, S. L.; Carver, A.; Castillo, R.; Catanesi, M. G.; Cavata, C.; Cazes, A.; Cervera, A.; Charrier, J. P.; Chavez, C.; Choi, S.; Chollet, S.; Christodoulou, G.; Colas, P.; Coleman, J.; Coleman, W.; Collazuol, G.; Connolly, K.; Cooke, P.; Curioni, A.; Dabrowska, A.; Danko, I.; Das, R.; Davies, G. S.; Davis, S.; Day, M.; De La Broise, X.; de Perio, P.; De Rosa, G.; Dealtry, T.; Debraine, A.; Delagnes, E.; Delbart, A.; Densham, C.; Di Lodovico, F.; Di Luise, S.; Dinh Tran, P.; Dobson, J.; Doornbos, J.; Dore, U.; Drapier, O.; Druillole, F.; Dufour, F.; Dumarchez, J.; Durkin, T.; Dytman, S.; Dziewiecki, M.; Dziomba, M.; Ellison, B.; Emery, S.; Ereditato, A.; Escallier, J. E.; Escudero, L.; Esposito, L. S.; Faszer, W.; Fechner, M.; Ferrero, A.; Finch, A.; Fisher, C.; Fitton, M.; Flight, R.; Forbush, D.; Frank, E.; Fransham, K.; Fujii, Y.; Fukuda, Y.; Gallop, M.; Galymov, V.; Ganetis, G. L.; Gannaway, F. C.; Gaudin, A.; Gaweda, J.; Gendotti, A.; George, M.; Giffin, S.; Giganti, C.; Gilje, K.; Giomataris, I.; Giraud, J.; Ghosh, A. K.; Golan, T.; Goldhaber, M.; Gomez-Cadenas, J. J.; Gomi, S.; Gonin, M.; Goyette, M.; Grant, A.; Grant, N.; Grañena, F.; Greenwood, S.; Gumplinger, P.; Guzowski, P.; Haigh, M. D.; Hamano, K.; Hansen, C.; Hara, T.; Harrison, P. F.; Hartfiel, B.; Hartz, M.; Haruyama, T.; Hasanen, R.; Hasegawa, T.; Hastings, N. C.; Hastings, S.; Hatzikoutelis, A.; Hayashi, K.; Hayato, Y.; Haycock, T. D. J.; Hearty, C.; Helmer, R. L.; Henderson, R.; Herlant, S.; Higashi, N.; Hignight, J.; Hiraide, K.; Hirose, E.; Holeczek, J.; Honkanen, N.; Horikawa, S.; Hyndman, A.; Ichikawa, A. K.; Ieki, K.; Ieva, M.; Iida, M.; Ikeda, M.; Ilic, J.; Imber, J.; Ishida, T.; Ishihara, C.; Ishii, T.; Ives, S. J.; Iwasaki, M.; Iyogi, K.; Izmaylov, A.; Jamieson, B.; Johnson, R. A.; Joo, K. K.; Jover-Manas, G.; Jung, C. K.; Kaji, H.; Kajita, T.; Kakuno, H.; Kameda, J.; Kaneyuki, K.; Karlen, D.; Kasami, K.; Kasey, V.; Kato, I.; Kawamuko, H.; Kearns, E.; Kellet, L.; Khabibullin, M.; Khaleeq, M.; Khan, N.; Khotjantsev, A.; Kielczewska, D.; Kikawa, T.; Kim, J. Y.; Kim, S.-B.; Kimura, N.; Kirby, B.; Kisiel, J.; Kitching, P.; Kobayashi, T.; Kogan, G.; Koike, S.; Komorowski, T.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koseki, K.; Koshio, Y.; Kouzuma, Y.; Kowalik, K.; Kravtsov, V.; Kreslo, I.; Kropp, W.; Kubo, H.; Kubota, J.; Kudenko, Y.; Kulkarni, N.; Kurchaninov, L.; Kurimoto, Y.; Kurjata, R.; Kurosawa, Y.; Kutter, T.; Lagoda, J.; Laihem, K.; Langstaff, R.; Laveder, M.; Lawson, T. B.; Le, P. T.; Le Coguie, A.; Le Ross, M.; Lee, K. P.; Lenckowski, M.; Licciardi, C.; Lim, I. T.; Lindner, T.; Litchfield, R. P.; Longhin, A.; Lopez, G. D.; Lu, P.; Ludovici, L.; Lux, T.; Macaire, M.; Magaletti, L.; Mahn, K.; Makida, Y.; Malafis, C. J.; Malek, M.; Manly, S.; Marchionni, A.; Mark, C.; Marino, A. D.; Marone, A. J.; Marteau, J.; Martin, J. F.; Maruyama, T.; Maryon, T.; Marzec, J.; Masliah, P.; Mathie, E. L.; Matsumura, C.; Matsuoka, K.; Matveev, V.; Mavrokoridis, K.; Mazzucato, E.; McCauley, N.; McFarland, K. S.; McGrew, C.; McLachlan, T.; Mercer, I.; Messina, M.; Metcalf, W.; Metelko, C.; Mezzetto, M.; Mijakowski, P.; Miller, C. A.; Minamino, A.; Mineev, O.; Mine, S.; Minvielle, R. E.; Mituka, G.; Miura, M.; Mizouchi, K.; Mols, J.-P.; Monfregola, L.; Monmarthe, E.; Moreau, F.; Morgan, B.; Moriyama, S.; Morris, D.; Muir, A.; Murakami, A.; Muratore, J. F.; Murdoch, M.; Murphy, S.; Myslik, J.; Nagashima, G.; Nakadaira, T.; Nakahata, M.; Nakamoto, T.; Nakamura, K.; Nakayama, S.; Nakaya, T.; Naples, D.; Nelson, B.; Nicholls, T. C.; Nishikawa, K.; Nishino, H.; Nitta, K.; Nizery, F.; Nowak, J. A.; Noy, M.; Obayashi, Y.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Okumura, K.; Okusawa, T.; Ohlmann, C.; Olchanski, K.; Openshaw, R.; Oser, S. M.; Otani, M.; Owen, R. A.; Oyama, Y.; Ozaki, T.; Pac, M. Y.; Palladino, V.; Paolone, V.; Paul, P.; Payne, D.; Pearce, G. F.; Pearson, C.; Perkin, J. D.; Pfleger, M.; Pierre, F.; Pierrepont, D.; Plonski, P.; Poffenberger, P.; Poplawska, E.; Popov, B.; Posiadala, M.; Poutissou, J.-M.; Poutissou, R.; Preece, R.; Przewlocki, P.; Qian, W.; Raaf, J. L.; Radicioni, E.; Ramos, K.; Ratoff, P.; Raufer, T. M.; Ravonel, M.; Raymond, M.; Retiere, F.; Richards, D.; Ritou, J.-L.; Robert, A.; Rodrigues, P. A.; Rondio, E.; Roney, M.; Rooney, M.; Ross, D.; Rossi, B.; Roth, S.; Rubbia, A.; Ruterbories, D.; Sacco, R.; Sadler, S.; Sakashita, K.; Sanchez, F.; Sarrat, A.; Sasaki, K.; Schaack, P.; Schmidt, J.; Scholberg, K.; Schwehr, J.; Scott, M.; Scully, D. I.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Sheffer, G.; Shibata, M.; Shimizu, Y.; Shiozawa, M.; Short, S.; Siyad, M.; Smith, D.; Smith, R. J.; Smy, M.; Sobczyk, J.; Sobel, H.; Sooriyakumaran, S.; Sorel, M.; Spitz, J.; Stahl, A.; Stamoulis, P.; Star, O.; Statter, J.; Stawnyczy, L.; Steinmann, J.; Steffens, J.; Still, B.; Stodulski, M.; Stone, J.; Strabel, C.; Strauss, T.; Sulej, R.; Sutcliffe, P.; Suzuki, A.; Suzuki, K.; Suzuki, S.; Suzuki, S. Y.; Suzuki, Y.; Suzuki, Y.; Swierblewski, J.; Szeglowski, T.; Szeptycka, M.; Tacik, R.; Tada, M.; Tadepalli, A. S.; Taguchi, M.; Takahashi, S.; Takeda, A.; Takenaga, Y.; Takeuchi, Y.; Tanaka, H. A.; Tanaka, K.; Tanaka, M.; Tanaka, M. M.; Tanimoto, N.; Tashiro, K.; Taylor, I. J.; Terashima, A.; Terhorst, D.; Terri, R.; Thompson, L. F.; Thorley, A.; Thorpe, M.; Toki, W.; Tomaru, T.; Totsuka, Y.; Touramanis, C.; Tsukamoto, T.; Tvaskis, V.; Tzanov, M.; Uchida, Y.; Ueno, K.; Usseglio, M.; Vacheret, A.; Vagins, M.; Van Schalkwyk, J. F.; Vanel, J.-C.; Vasseur, G.; Veledar, O.; Vincent, P.; Wachala, T.; Waldron, A. V.; Walter, C. W.; Wanderer, P. J.; Ward, M. A.; Ward, G. P.; Wark, D.; Warner, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wendland, J.; West, N.; Whitehead, L. H.; Wikström, G.; Wilkes, R. J.; Wilking, M. J.; Williamson, Z.; Wilson, J. R.; Wilson, R. J.; Wong, K.; Wongjirad, T.; Yamada, S.; Yamada, Y.; Yamamoto, A.; Yamamoto, K.; Yamanoi, Y.; Yamaoka, H.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Zalewska, A.; Zalipska, J.; Zaremba, K.; Ziembicki, M.; Zimmerman, E. D.; Zito, M.; Zmuda, J.; T2K Collaboration

    2011-12-01

    The T2K experiment is a long baseline neutrino oscillation experiment. Its main goal is to measure the last unknown lepton sector mixing angle θ13 by observing νe appearance in a νμ beam. It also aims to make a precision measurement of the known oscillation parameters, Δm232 and sin22θ23, via νμ disappearance studies. Other goals of the experiment include various neutrino cross-section measurements and sterile neutrino searches. The experiment uses an intense proton beam generated by the J-PARC accelerator in Tokai, Japan, and is composed of a neutrino beamline, a near detector complex (ND280), and a far detector (Super-Kamiokande) located 295 km away from J-PARC. This paper provides a comprehensive review of the instrumentation aspect of the T2K experiment and a summary of the vital information for each subsystem.

  2. Generation of Collapsed Cross Sections for Hatch 1 Cycles 1-3

    SciTech Connect

    Ade, Brian J

    2012-11-01

    Under NRC JCN V6361, Oak Ridge National Laboratory (ORNL) was tasked to develop and run SCALE/TRITON models for generation of collapsed few-group cross sections and to convert the cross sections to PMAXS format using the GENPMAXS conversion utility for use in PARCS/PATHS simulations of Hatch Unit 1, cycles 1-3. This letter report documents the final models used to produce the Hatch collapsed cross sections.

  3. Spectroscopic study of {Lambda}(1405) via the in-flight (K{sup -},n) reaction on deuteron

    SciTech Connect

    Enomoto, S.; Inoue, K.; Ishibashi, N.; Kawasaki, S.; Sakaguchi, A.; Yoshida, K.; Ajimura, S.; Noumi, H.; Beer, G.; Bhang, H.; Choi, S.; Yim, H.; Bragadireanu, M.; Curceanu, C.; Guaraldo, C.; Okada, S.; Sirghi, D.; Sirghi, F.; Buehler, P.; Cargnelli, M.

    2011-10-21

    We present an experimental study of {Lambda}(1405) via the in-flight (K{sup -},n) reaction on the deuteron target (J-PARC E31). We will measure all {Sigma}{sup +}{pi}{sup -}, {Sigma}{sup -}{pi}{sup +} and {Sigma}{sup 0}{pi}{sup 0} final states so that the isospin structure of the produced hyperon resonance state can be decomposed. In this report, we present an overview of the experiment and preparation status.

  4. RMS ENVELOPE BACK-PROPAGATION IN THE XAL ONLINE MODEL

    SciTech Connect

    Allen, Christopher K; Sako, Hiroyuki; Ikegami, Masanori

    2009-01-01

    The ability to back-propagate RMS envelopes was added to the J-PARC XAL online model. Specifically, given an arbitrary downstream location, the online model can propagate the RMS envelopes backward to an arbitrary upstream location. This feature provides support for algorithms estimating upstream conditions from downstream data. The upgrade required significant refactoring, which we outline. We also show simulations using the new feature.

  5. Quasielastic Neutron Scattering Study on Polymer Nanocomposites

    NASA Astrophysics Data System (ADS)

    Masui, T.; Kishimoto, H.; Kikuchi, T.; Ohira-Kawamura, S.; Inamura, Y.; Koga, T.; Nakajima, K.

    2014-04-01

    By using a quasielastic neutron scattering technique (disk-chopper-type spectrometer AMATERAS at J-PARC), we have investigated the microscopic dynamics of polybutadiene (PB) in which silica particles were embedded. The experimental results gave us both a damped vibration mode of PB and jumped diffusion motion of the segments. It was found that these dynamical features remain unaffected by the presence of the silica particle, while the residence time of the jumped diffusion motion becomes longer at the high filler loading.

  6. Development of Silicon Strip Detector for the measurement of the {Xi}-atom X-rays

    SciTech Connect

    Sugimura, H.; Adachi, S.; Imai, K.; Sako, H.; Sato, S.; Tanida, K.; Kiuchi, R.; Joo, C. W.

    2011-10-21

    We have developed the Silicon Strip Detector (SSD) for the experiment to measure X-ray from {Xi}-atom. The feature of the SSD is to measure positions of particles and energy deposit. We have carried out the test experiment at J-PARC K1.8 beam line. The three SSDs were installed in front of the target and we tested by using kaon beam. In this paper, the results of the test experiment is presented.

  7. QCD Prediction of ATT for Small QT Dimuon Production in pp and pp-bar Collisions

    SciTech Connect

    Kawamura, Hiroyuki; Kodaira, Jiro; Tanaka, Kazuhiro

    2007-06-13

    We present QCD prediction of double-spin asymmetries (ATT) in transversely polarized Drell-Yan process at small transverse momentum QT of dimuon. Resummation of large logarithmic corrections, relevant in small QT region, is performed up to next-to-leading logarithmic (NLL) accuracy. ATT at RHIC, J-PARC and GSI are studied numerically in the corresponding kinematic regions. We show that the large ATT is obtained for small QT and moderate energies.

  8. Chiral-odd TMDs in Drell-Yan processes

    NASA Astrophysics Data System (ADS)

    Lu, Zhun

    2014-01-01

    We calculate the Boer-Mulders function of the pion by applying the MIT bag model, and compare the result with that from the spectator model. We then study the azimuthal asymmetries contributed by the chiral-odd transverse momentum distributions in pion-nucleon Drell-Yan process at COMPASS and in proton-proton Drell-Yan process at RHIC, J-PARC, E906 and NICA.

  9. Characterization of levofloxacin non-susceptible clinical Streptococcus pyogenes isolated in the central part of Italy.

    PubMed

    Petrelli, D; Di Luca, M C; Prenna, M; Bernaschi, P; Repetto, A; Vitali, L A

    2014-02-01

    We investigated the prevalence, genetics, and clonality of fluoroquinolone non-susceptible isolates of Streptococcus pyogenes in the central part of Italy. S. pyogenes strains (n = 197) were isolated during 2012 from patients with tonsillopharyngitis, skin, wound or invasive infections and screened for fluoroquinolone non-susceptibility (resistance to norfloxacin and levofloxacin minimum inhibitory concentration (MIC) = 2 mg/L) following EUCAST guidelines. First-step topoisomerase parC and gyrA substitutions were investigated using sequencing analysis. Clonality was determined by pulsed field gel electrophoresis (PFGE; SmaI digestion) and by emm typing. The fluoroquinolone non-susceptible phenotype was identified in 18 isolates (9.1 %) and correlated with mutations in parC, but not in gyrA, the most frequent leading to substitution of the serine at position 79 with an alanine. Most of the fluoroquinolone non-susceptible isolates belonged to the emm-type 6, even if other emm-types were also represented (emm75, emm89, and emm2). A significant level of association was measured between PFGE and both emm type and substitutions in parC. The prevalence of fluoroquinolone non-susceptible Streptococcus pyogenes isolates in Italy is of concern and, although the well-known emm type 6 is dominant, other types are appearing and spreading.

  10. Trace Assessment for BWR ATWS Analysis

    SciTech Connect

    Cheng, L.Y.; Diamond, D.; Arantxa Cuadra, Gilad Raitses, Arnold Aronson

    2010-04-22

    A TRACE/PARCS input model has been developed in order to be able to analyze anticipated transients without scram (ATWS) in a boiling water reactor. The model is based on one developed previously for the Browns Ferry reactor for doing loss-of-coolant accident analysis. This model was updated by adding the control systems needed for ATWS and a core model using PARCS. The control systems were based on models previously developed for the TRAC-B code. The PARCS model is based on information (e.g., exposure and moderator density (void) history distributions) obtained from General Electric Hitachi and cross sections for GE14 fuel obtained from an independent source. The model is able to calculate an ATWS, initiated by the closure of main steam isolation valves, with recirculation pump trip, water level control, injection of borated water from the standby liquid control system and actuation of the automatic depres-surization system. The model is not considered complete and recommendations are made on how it should be improved.

  11. Use of Navier-Stokes methods for the calculation of high-speed nozzle flow fields

    NASA Technical Reports Server (NTRS)

    Georgiadis, Nicholas J.; Yoder, Dennis A.

    1994-01-01

    Flows through three reference nozzles have been calculated to determine the capabilities and limitations of the widely used Navier-Stokes solver, PARC. The nozzles examined have similar dominant flow characteristics as those considered for supersonic transport programs. Flows from an inverted velocity profile (IVP) nozzle, an under expanded nozzle, and an ejector nozzle were examined. PARC calculations were obtained with its standard algebraic turbulence model, Thomas, and the two-equation turbulence model, Chien k-epsilon. The Thomas model was run with the default coefficient of mixing set at both 0.09 and a larger value of 0.13 to improve the mixing prediction. Calculations using the default value substantially underpredicted the mixing for all three flows. The calculations obtained with the higher mixing coefficient better predicted mixing in the IVP and underexpanded nozzle flows but adversely affected PARC's convergence characteristics for the IVP nozzle case. The ejector nozzle case did not converge with the Thomas model and the higher mixing coefficient. The Chien k-epsilon results were in better agreement with the experimental data overall than were those of the Thomas run with the default mixing coefficient, but the default boundary conditions for k and epsilon underestimated the levels of mixing near the nozzle exits.

  12. Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to Streptococcus pneumoniae

    PubMed Central

    Balsalobre, Luz; Ferrándiz, María José; Liñares, Josefina; Tubau, Fe; de la Campa, Adela G.

    2003-01-01

    A total of 46 ciprofloxacin-resistant (Cipr) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cipr isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae. PMID:12821449

  13. Changes in Fluoroquinolone-Resistant Streptococcus pneumonia after 7-Valent Conjugate Vaccination, Spain

    PubMed Central

    Ardanuy, Carmen; Balsalobre, Luz; Pérez-Trallero, Emilio; Marimón, Jose M.; Fenoll, Asunción; Liñares, Josefina

    2009-01-01

    Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4–8 μg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC ≥16 μg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006. PMID:19523289

  14. A computational fluid dynamics simulation of the hypersonic flight of the Pegasus(TM) vehicle using an artificial viscosity model and a nonlinear filtering method. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Mendoza, John Cadiz

    1995-01-01

    The computational fluid dynamics code, PARC3D, is tested to see if its use of non-physical artificial dissipation affects the accuracy of its results. This is accomplished by simulating a shock-laminar boundary layer interaction and several hypersonic flight conditions of the Pegasus(TM) launch vehicle using full artificial dissipation, low artificial dissipation, and the Engquist filter. Before the filter is applied to the PARC3D code, it is validated in one-dimensional and two-dimensional form in a MacCormack scheme against the Riemann and convergent duct problem. For this explicit scheme, the filter shows great improvements in accuracy and computational time as opposed to the nonfiltered solutions. However, for the implicit PARC3D code it is found that the best estimate of the Pegasus experimental heat fluxes and surface pressures is the simulation utilizing low artificial dissipation and no filter. The filter does improve accuracy over the artificially dissipative case but at a computational expense greater than that achieved by the low artificial dissipation case which has no computational time penalty and shows better results. For the shock-boundary layer simulation, the filter does well in terms of accuracy for a strong impingement shock but not as well for weaker shock strengths. Furthermore, for the latter problem the filter reduces the required computational time to convergence by 18.7 percent.

  15. A High Power Test Method for Pattern Magnet Power Supplies with Capacitor Banks

    NASA Astrophysics Data System (ADS)

    Kurimoto, Yoshinori; Morita, Yuichi; Sagawa, Ryu; Shimogawa, Tetsushi; Miura, Kazuki

    In the J-PARC Main Ring (MR), we plan to increase the beam intensity from 230 to 750 kW. To achieve this, the synchrotron repetition period must be shortened from 2.48 s to approximately 1 s using new power supplies for the main magnets. We are currently researching and developing new power supplies with large capacitor banks. Such banks are needed to reduce the power variation at the main grid in the J-PARC site for future operations with shorter repetition periods. However, it is very difficult to test the new power supplies at their rated power before installation. This is because the power handled by the power supplies used for the J-PARC MR main magnets is too high to be tested in factories or laboratories. To overcome this problem, we suggest a test method involving the use of two capacitor banks. In this method, two power supplies and a small inductive load are connected between two capacitor banks. By controlling the energy flow between the two capacitor banks in this setup, the received power and inductive load can be kept very small. This article describes the details of the control method and the results of the test experiment using a mini-model power supply.

  16. Rat parotid gland cell differentiation in three-dimensional culture.

    PubMed

    Baker, Olga J; Schulz, David J; Camden, Jean M; Liao, Zhongji; Peterson, Troy S; Seye, Cheikh I; Petris, Michael J; Weisman, Gary A

    2010-10-01

    The use of polarized salivary gland cell monolayers has contributed to our understanding of salivary gland physiology. However, these cell models are not representative of glandular epithelium in vivo, and, therefore, are not ideal for investigating salivary epithelial functions. The current study has developed a three-dimensional (3D) cell culture model for rat Par-C10 parotid gland cells that forms differentiated acinar-like spheres on Matrigel. These 3D Par-C10 acinar-like spheres display characteristics similar to differentiated acini in salivary glands, including cell polarization, tight junction (TJ) formation required to maintain transepithelial potential difference, basolateral expression of aquaporin-3 and Na+/K+/2Cl- cotransporter-1, and responsiveness to the muscarinic receptor agonist carbachol that is decreased by the anion channel blocker diphenylamine-2-carboxylic acid or chloride replacement with gluconate. Incubation of the spheres in the hypertonic medium increased the expression level of the water channel aquaporin-5. Further, the proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma induced alterations in TJ integrity in the acinar-like spheres without affecting individual cell viability, suggesting that cytokines may affect salivary gland function by altering TJ integrity. Thus, 3D Par-C10 acinar-like spheres represent a novel in vitro model to study physiological and pathophysiological functions of differentiated acini.

  17. Toward construction of a unified neutrino-nucleus interaction model

    NASA Astrophysics Data System (ADS)

    Kamano, Hiroyuki

    2014-09-01

    A precise knowledge of the neutrino-nucleus interactions is becoming one of the crucial issues for a successful determination of the neutrino parameters from the future neutrino-oscillation experiments. It is therefore urgent to have a reliable neutrino-nucleus interactoin model that enables a quantitative description of neutrino-nucleus reaction cross sections in an accuracy of 10 percent or less. However, the kinematic regions relevant to the neutrino parameter searches extend over the quasi-elastic, resonance, and deep-inelastic-scattering regions, where different theoretical treatments based on hadronic or partonic degrees of freedom are usually employed, and this makes the construction of a unified neutrino-nucleus interaction model covering those kinematic regions challenging. To tackle on such a challenging issue, we have recently developed a collaboration of experimentalists and theorists in different fields at J-PARC Branch of KEK Theory Center (http://www.nuint.kek.jp/index_e.html). In this talk, I review our efforts toward construction of the unified neutrino-nucleus interaction model at J-PARC Branch of KEK Theory Center. A precise knowledge of the neutrino-nucleus interactions is becoming one of the crucial issues for a successful determination of the neutrino parameters from the future neutrino-oscillation experiments. It is therefore urgent to have a reliable neutrino-nucleus interactoin model that enables a quantitative description of neutrino-nucleus reaction cross sections in an accuracy of 10 percent or less. However, the kinematic regions relevant to the neutrino parameter searches extend over the quasi-elastic, resonance, and deep-inelastic-scattering regions, where different theoretical treatments based on hadronic or partonic degrees of freedom are usually employed, and this makes the construction of a unified neutrino-nucleus interaction model covering those kinematic regions challenging. To tackle on such a challenging issue, we have

  18. Double Lambda and Xi hypernuclei

    NASA Astrophysics Data System (ADS)

    Nakazawa, Kazuma

    2014-09-01

    Nuclei with double strangeness (S = -2) provide the key information to understand Baryon-Baryon interaction under the SU(3)f symmetry. Therefore we have carried out the experiments at KEK for quarter a century. Recently, the interaction in S = -2 sector is noted to derive the information of the EOS of neutron star. The Lambda-Lambda interaction has been presented to be weak attractive by NAGARA event which showed the production and decay of 6He double-hypernucleus. The event also presented the lower mass limit of H dibaryon. In other five events, we obtained the knowledge about an excitation level of 10Be double-hypernucleus under the consistency with NAGARA event. Moreover, very recently, we have discovered a Xi-14N system which was deeply bound far from the atomic 3D level (0.17 MeV) for a captured Xi hyperon. Since a 8Li nucleus was associated with the decay of one of twin-hypernuclei, the event was uniquely identified as Xi- + 14N ==> 10BeL + 5HeL. The system was selected from 8 million pictures on the test running for development of ``Overall Scanning'' to be used in the coming experiment. This is the first evidence of Xi hypernucleus to be bound and it is impacting for the study of Xi-N interaction. At J-PARC facility, for the further study of hyperon-hyperon interaction, we plan to perform the E07 experiment at J-PARC. In the workshop, we will review the above knowledge obtained by the experiments at KEK-PS, and discuss developed technologies to detected 102 or more double-hypernuclei in the E07 experiment at J-PARC. Nuclei with double strangeness (S = -2) provide the key information to understand Baryon-Baryon interaction under the SU(3)f symmetry. Therefore we have carried out the experiments at KEK for quarter a century. Recently, the interaction in S = -2 sector is noted to derive the information of the EOS of neutron star. The Lambda-Lambda interaction has been presented to be weak attractive by NAGARA event which showed the production and decay of 6He

  19. Impact of imiglucerase supply shortage on clinical and laboratory parameters in Norrbottnian patients with Gaucher disease type 3.

    PubMed

    Machaczka, Maciej; Kämpe Björkvall, Cecilia; Wieremiejczyk, Joanna; Paucar Arce, Martin; Myhr-Eriksson, Kristina; Klimkowska, Monika; Hägglund, Hans; Svenningsson, Per

    2015-02-01

    A viral contamination of the production plant producing imiglucerase (Cerezyme™) resulted in an unpredicted worldwide shortage of global supplies during 2009-2010. The aim of the study was to describe the effects of dose reduction of enzyme replacement therapy (ERT) in adults with Norrbottnian form of Gaucher disease type 3 (N-GD3). There were ten adults with N-GD3 treated with imiglucerase in the county of Norrbotten in June 2009. Analyzed variables included plasma chitotriosidase activity and concentration of CCL18/PARC, whole blood hemoglobin concentration (Hb) and platelet count (PLT), as well as patients' body weight, subjective complaints and health status measured by the EuroQoL-5D questionnaire. The median duration of ERT shortage lasted for 14 months (10-20 months). The median percentage reduction of imiglucerase dose was 36 % (26-59 %). Hb decreased in four patients, PLT decreased in three patients, chitotriosidase increased in three patients (max. +22 % of baseline), and CCL18/PARC increased in six patients (+14 % to +57 %). The body weight was moderately decreased in one patient. No new bone events were noted. Self-assessment of individual patient's health status was stable in all but one patient. Our results suggest that moderate reduction of ERT dosage lasting for relatively short period of time can lead to worsening in biomarkers of adults with N-GD3. However, this worsening is infrequently translated to clinical worsening of patients. It is possible that CCL18/PARC has a higher sensitivity than chitotriosidase in monitoring of ERT dosing in GD3. PMID:25205209

  20. Modulation of Hepatocarcinoma Cell Morphology and Activity by Parylene-C Coating on PDMS

    PubMed Central

    Guimard, Denis; Arakawa, Yasuhiko; Sakai, Yasuyuki; Fujii, Teruo

    2010-01-01

    Background The ability to understand and locally control the morphogenesis of mammalian cells is a fundamental objective of cell and developmental biology as well as tissue engineering research. We present parylene-C (ParC) deposited on polydimethylsiloxane (PDMS) as a new substratum for in vitro advanced cell culture in the case of Human Hepatocarcinoma (HepG2) cells. Principal Findings Our findings establish that the intrinsic properties of ParC-coated PDMS (ParC/PDMS) influence and modulate initial extracellular matrix (ECM; here, type-I collagen) surface architecture, as compared to non-coated PDMS substratum. Morphological changes induced by the presence of ParC on PDMS were shown to directly affect liver cell metabolic activity and the expression of transmembrane receptors implicated in cell adhesion and cell-cell interaction. These changes were characterized by atomic force microscopy (AFM), which elucidated differences in HepG2 cell adhesion, spreading, and reorganization into two- or three-dimensional structures by neosynthesis of ECM components. Local modulation of cell aggregation was successfully performed using ParC/PDMS micropatterns constructed by simple microfabrication. Conclusion/Significance We demonstrated for the first time the modulation of HepG2 cells' behavior in relation to the intrinsic physical properties of PDMS and ParC, enabling the local modulation of cell spreading in a 2D or 3D manner by simple microfabrication techniques. This work will provide promising insights into the development of cell-based platforms that have many applications in the field of in vitro liver tissue engineering, pharmacology and therapeutics. PMID:20300511

  1. Isolation and characterization of multidrug-resistant Klebsiella spp. isolated from shrimp imported from Thailand.

    PubMed

    Nawaz, Mohamed; Khan, S A; Tran, Q; Sung, K; Khan, A A; Adamu, I; Steele, R S

    2012-04-16

    A study was undertaken to isolate and characterize tetracycline and nalidixic acid-resistant Klebsiella spp. in farm-raised, imported shrimp sold in the United States. Sixty-seven multiple antibiotic-resistant Klebsiella spp. strains were isolated from imported shrimp samples. Using morphological and biochemical methods, fifty-three strains were tentatively identified as Klebsiella pneumoniae and fourteen as K. oxytoca. Although all isolates were resistant to tetracycline, only 8 were resistant to nalidixic acid. These 8 isolates were further screened by PCR for quinolone resistance genes (qnrA, B, S, gyrA, B and parC). PCR protocols failed to amplify any qnr genes. The purified PCR amplicons of gyrA, gyrB and parC were sequenced and analyzed for point mutations that confer resistance to fluoroquinolone antibiotics. Analysis of the sequences of the gyrA amplicons from nalidixic acid-resistant Klebsiella spp. indicated two point mutations in gyrA at positions 83 (Ser→Phe) and 87 (Asp→Ala). Sequence analysis of the parC amplicons indicated an amino acid change at position 80 (Ser→Ile). No mutations were detected in gyrB. Template DNA from all isolates was screened for tetracycline resistance genes (tetA-E). Oligonucleotide primers specifically targeting a 305-bp region of tetB and a 477-bp region of tetD successfully amplified sequences from 91.0 and 44.0% of the isolates, respectively. None of the isolates contained tetA, tetC or tetE genes. Plasmids (2.0-16.0kb) were found in 23 of the 67 isolates. XbaI-PFGE identified 32 distinct macro restriction patterns (mrps) among the 61 multiple drug-resistant Klebsiella spp. that were typable. Our results indicate that imported shrimp is a reservoir for multidrug resistant Klebsiella spp. and potential health risks posed by such strains should not be underestimated.

  2. Nonoptimal DNA Topoisomerases Allow Maintenance of Supercoiling Levels and Improve Fitness of Streptococcus pneumoniae ▿

    PubMed Central

    Balsalobre, Luz; Ferrándiz, María José; de Alba, Gabriela; de la Campa, Adela G.

    2011-01-01

    Fluoroquinolones, which target gyrase and topoisomerase IV, are used for treating Streptococcus pneumoniae infections. Fluoroquinolone resistance in this bacterium can arise via point mutation or interspecific recombination with genetically related streptococci. Our previous study on the fitness cost of resistance mutations and recombinant topoisomerases identified GyrAE85K as a high-cost change. However, this cost was compensated for by the presence of a recombinant topoisomerase IV (parC and parE recombinant genes) in strain T14. In this study, we purified wild-type and mutant topoisomerases and compared their enzymatic activities. In strain T14, both gyrase carrying GyrAE85K and recombinant topoisomerase IV showed lower activities (from 2.0- to 3.7-fold) than the wild-type enzymes. These variations of in vitro activity corresponded to changes of in vivo supercoiling levels that were analyzed by two-dimensional electrophoresis of an internal plasmid. Strains carrying GyrAE85K and nonrecombinant topoisomerases had lower (11.1% to 14.3%) supercoiling density (σ) values than the wild type. Those carrying GyrAE85K and recombinant topoisomerases showed either partial or total supercoiling level restoration, with σ values being 7.9% (recombinant ParC) and 1.6% (recombinant ParC and recombinant ParE) lower than those for the wild type. These data suggested that changes acquired by interspecific recombination might be selected because they reduce the fitness cost associated with fluoroquinolone resistance mutations. An increase in the incidence of fluoroquinolone resistance, even in the absence of further antibiotic exposure, is envisaged. PMID:21173181

  3. Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype

    PubMed Central

    Agnello, Melissa; Finkel, Steven E.; Wong-Beringer, Annie

    2016-01-01

    Fluoroquinolone (FQ) resistance is highly prevalent among clinical strains of Pseudomonas aeruginosa, limiting treatment options. We have reported previously that highly virulent strains containing the exoU gene of the type III secretion system are more likely to be FQ-resistant than strains containing the exoS gene, as well as more likely to acquire resistance-conferring mutations in gyrA/B and parC/E. We hypothesize that FQ-resistance imposes a lower fitness cost on exoU compared to exoS strains, thus allowing for better adaptation to the FQ-rich clinical environment. We created isogenic mutants containing a common FQ-resistance conferring point mutation in parC from three exoU to three exoS clinical isolates and tested fitness in vitro using head-to-head competition assays. The mutation differentially affected fitness in the exoU and exoS strains tested. While the addition of the parC mutation dramatically increased fitness in one of the exoU strains leaving the other two unaffected, all three exoS strains displayed a general decrease in fitness. In addition, we found that exoU strains may be able to compensate for the fitness costs associated with the mutation through better regulation of supercoiling compared to the exoS strains. These results may provide a biological explanation for the observed predominance of the virulent exoU genotype in FQ-resistant clinical subpopulations and represent the first investigation into potential differences in fitness costs of FQ-resistance that are linked to the virulence genotype of P. aeruginosa. Understanding the fitness costs of antibiotic resistance and possibilities of compensation for these costs is essential for the rational development of strategies to combat the problem of antibiotic resistance. PMID:27757111

  4. Molecular characterization of quinolone-resistant Neisseria gonorrhoeae isolates from Brazil.

    PubMed

    Uehara, Aline A; Amorin, Efigênia L T; Ferreira, Maria de Fátima; Andrade, Claudia F; Clementino, Maysa B M; de Filippis, Ivano; Neves, Felipe P G; Pinto, Tatiana de C A; Teixeira, Lúcia M; Giambiagi-Demarval, Marcia; Fracalanzza, Sérgio E L

    2011-12-01

    Despite the rapid spread of antibiotic resistance among gonococci worldwide, limited reports are available from Brazilian locations. In the present study, 25 quinolone-resistant Neisseria gonorrhoeae (QRNG) strains isolated in Rio de Janeiro, Brazil, were characterized by phenotypic and molecular methods, including analysis of mutations in the gyrA and parC genes. They represented 16.5% of the N. gonorrhoeae isolates obtained during a survey performed from 2006 to 2010. A trend for increasing resistance to ciprofloxacin was observed in the period investigated. The most prevalent pattern of mutation observed among QRNG isolates, Ser-91 to Phe and Asp-95 to Gly in gyrA and Ser-87 to Arg in parC, was detected in 40% of the isolates exhibiting MICs ranging from 4 to >32 μg/ml. Rare types of mutations were found in the gyrA gene (Gln-102 to His [12%] and Asp-95 to Tyr [4%]) and in the parC gene (Ser-88 to Thr [4%]). The genetic relationship of the QRNG isolates, evaluated by pulsed-field gel electrophoresis, suggested that the increase in the frequencies of the QRNG isolates in Rio de Janeiro, Brazil, may have arisen as a result of simultaneous spread of two clonal groups. The results also indicate that fluoroquinolones may no longer be used as first line antibiotics for the treatment of gonorrhea in Rio de Janeiro, and that programs for antimicrobial susceptibility surveillance of N. gonorrhoeae should also be implemented in other regions of Brazil. PMID:21976763

  5. Molecular characterisation of quinolone resistance in Escherichia coli from animals in Turkey.

    PubMed

    Cengiz, M; Buyukcangaz, E; Arslan, E; Mat, B; Sahinturk, P; Sonal, S; Gocmen, H; Sen, A

    2012-08-11

    The aim of this study were to detect the gyrA, parC and marR mutations and qnr genes (qnrA, qnrB and qnrS) in 120 strains of Escherichia coli isolated from animals. European Committee on Antimicrobial Susceptibility Testing and Clinical Laboratory Standards Institute disc diffusion and minimum inhibitory concentration (MIC) tests, respectively, were used to determine fluoroquinolone (FQ) resistance, and molecular methods were used to detect the mutations and the genes. E coli isolates with an MIC of ≥8 mg/l had mutation at Ser-80 in parC in addition to mutations at Ser-83, Asp-87 or both in gyrA. The nucleotide change was detected in marR (Ser-3 → Asn, Ala-53 → Glu, Gly-103 → Ser, Tyr-137 → His). Only four E coli isolates (3.3 per cent) contained qnrA and qnrS, and qnrB was not detected. Two E coli isolates from healthy calves also contained qnrA and qnrS. The MICs of enrofloxacin and danofloxacin for qnr-containing E coli isolates ranged from 32 mg/l to 256 mg/l. The results of this study indicated that the FQ-resistant E coli isolates presented an alteration in gyrA (Ser-83 → Leu, Asp-87 → Asn) and parC (Ser-80 → Ile) with high MICs (8-256 mg/l), and there was a low prevalence of qnr genes among E coli isolated from animals. PMID:22890400

  6. Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters.

    PubMed

    Soscia, David A; Sequeira, Sharon J; Schramm, Robert A; Jayarathanam, Kavitha; Cantara, Shraddha I; Larsen, Melinda; Castracane, James

    2013-09-01

    There is a need for an artificial salivary gland as a long-term remedy for patients suffering from salivary hypofunction, a leading cause of chronic xerostomia (dry mouth). Current salivary gland tissue engineering approaches are limited in that they either lack sufficient physical cues and surface area needed to facilitate epithelial cell differentiation, or they fail to provide a mechanism for assembling an interconnected branched network of cells. We have developed highly-ordered arrays of curved hemispherical "craters" in polydimethylsiloxane (PDMS) using wafer-level integrated circuit (IC) fabrication processes, and lined them with electrospun poly-lactic-co-glycolic acid (PLGA) nanofibers, designed to mimic the three-dimensional (3-D) in vivo architecture of the basement membrane surrounding spherical acini of salivary gland epithelial cells. These micropatterned scaffolds provide a method for engineering increased surface area and were additionally investigated for their ability to promote cell polarization. Two immortalized salivary gland cell lines (SIMS, ductal and Par-C10, acinar) were cultured on fibrous crater arrays of various radii and compared with those grown on flat PLGA nanofiber substrates, and in 3-D Matrigel. It was found that by increasing crater curvature, the average height of the cell monolayer of SIMS cells and to a lesser extent, Par-C10 cells, increased to a maximum similar to that seen in cells grown in 3-D Matrigel. Increasing curvature resulted in higher expression levels of tight junction protein occludin in both cell lines, but did not induce a change in expression of adherens junction protein E-cadherin. Additionally, increasing curvature promoted polarity of both cell lines, as a greater apical localization of occludin was seen in cells on substrates of higher curvature. Lastly, substrate curvature increased expression of the water channel protein aquaporin-5 (Aqp-5) in Par-C10 cells, suggesting that curved nanofiber substrates

  7. Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis.

    PubMed

    Crane, Daniel P; Gromov, Kirill; Li, Dan; Søballe, Kjeld; Wahnes, Christian; Büchner, Hubert; Hilton, Matthew J; O'Keefe, Regis J; Murray, Clinton K; Schwarz, Edward M

    2009-08-01

    Osteomyelitis (OM) from multidrug-resistant (MDR) Acinetobacter has emerged in >30% of combat-related injuries in Iraq and Afghanistan. While most of these strains are sensitive to colistin, the drug is not available in bone void fillers for local high-dose delivery. To address this, we developed a mouse model with MDR strains isolated from wounded military personnel. In contrast to S. aureus OM, which is osteolytic and characterized by biofilm in necrotic bone, A. baumannii OM results in blastic lesions that do not contain apparent biofilm. We also found that mice mount a specific IgG response against three proteins (40, 47, and 56 kDa) regardless of the strain used, suggesting that these may be immuno-dominant antigens. PCR for the A. baumannii-specific parC gene confirmed a 100% infection rate with 75% of the MDR strains, and in vitro testing confirmed that all strains were sensitive to colistin. We also developed a real-time quantitative PCR (RTQ-PCR) assay that could detect as few as 10 copies of parC in a sample. To demonstrate the efficacy of colistin prophylaxis in this model, mice were treated with either parenteral colistin (0.2 mg colistinmethate i.m. for 7 days), local colistin (PMMA bead impregnated with 1.0 mg colistin sulfate), or an unloaded PMMA bead control. While the parenteral colistin failed to demonstrate any significant effects versus the placebo, the colistin PMMA bead significantly reduced the infection rate such that only 29.2% of the mice had detectable levels of parC at 19 days (p < 0.05 vs. i.m. colistin and placebo).

  8. The chloroplast min system functions differentially in two specific nongreen plastids in Arabidopsis thaliana.

    PubMed

    Wang, Peng; Zhang, Jie; Su, Jianbin; Wang, Peng; Liu, Jun; Liu, Bing; Feng, Dongru; Wang, Jinfa; Wang, Hongbin

    2013-01-01

    The nongreen plastids, such as etioplasts, chromoplasts, etc., as well as chloroplasts, are all derived from proplastids in the meristem. To date, the Min system members in plants have been identified as regulators of FtsZ-ring placement, which are essential for the symmetrical division of chloroplasts. However, the regulation of FtsZ-ring placement in nongreen plastids is poorly understood. In this study, we investigated the division site placement of nongreen plastids by examining the etioplasts as representative in Arabidopsis Min system mutants. Surprisingly, the shape and number of etioplasts in cotyledons of arc3, arc11 and mcd1 mutants were similar to that observed in wild-type plants, whereas arc12 and parc6 mutants exhibited enlarged etioplasts that were reduced in number. In order to examine nongreen plastids in true leaves, we silenced the ALB3 gene in these Min system mutant backgrounds to produce immature chloroplasts without the thylakoidal network using virus induced gene silencing (VIGS). Interestingly, consistent with our observations in etioplasts, enlarged and fewer nongreen plastids were only detected in leaves of parc6 (VIGS-ALB3) and arc12 (VIGS-ALB3) plants. Further, the FtsZ-ring assembled properly at the midpoint in nongreen plastids of arc3, arc11 and mcd1 (VIGS-ALB3) plants, but organized into multiple rings in parc6 (VIGS-ALB3) and presented fragmented filaments in arc12 (VIGS-ALB3) plants, suggesting that division site placement in nongreen plastids requires fewer components of the plant Min system. Taken together, these results suggest that division site placement in nongreen plastids is different from that in chloroplasts.

  9. Rapid evolution of fluoroquinolone-resistant Escherichia coli in Nigeria is temporally associated with fluoroquinolone use

    PubMed Central

    2011-01-01

    Background Antibiotic resistance has necessitated fluoroquinolone use but little is known about the selective forces and resistance trajectory in malaria-endemic settings, where selection from the antimalarial chloroquine for fluoroquinolone-resistant bacteria has been proposed. Methods Antimicrobial resistance was studied in fecal Escherichia coli isolates in a Nigerian community. Quinolone-resistance determining regions of gyrA and parC were sequenced in nalidixic acid resistant strains and horizontally-transmitted quinolone-resistance genes were sought by PCR. Antimicrobial prescription practices were compared with antimicrobial resistance rates over a period spanning three decades. Results Before 2005, quinolone resistance was limited to low-level nalixidic acid resistance in fewer than 4% of E. coli isolates. In 2005, the proportion of isolates demonstrating low-level quinolone resistance due to elevated efflux increased and high-level quinolone resistance and resistance to the fluoroquinolones appeared. Fluoroquinolone resistance was attributable to single nucleotide polymorphisms in quinolone target genes gyrA and/or parC. By 2009, 35 (34.5%) of isolates were quinolone non-susceptible with nine carrying gyrA and parC SNPs and six bearing identical qnrS1 alleles. The antimalarial chloroquine was heavily used throughout the entire period but E. coli with quinolone-specific resistance mechanisms were only detected in the final half decade, immediately following the introduction of the fluoroquinolone antibacterial ciprofloxacin. Conclusions Fluoroquinolones, and not chloroquine, appear to be the selective force for fluoroquinolone-resistant fecal E. coli in this setting. Rapid evolution to resistance following fluoroquinolone introduction points the need to implement resistant containment strategies when new antibacterials are introduced into resource-poor settings with high infectious disease burdens. PMID:22060770

  10. The Chloroplast Min System Functions Differentially in Two Specific Nongreen Plastids in Arabidopsis thaliana

    PubMed Central

    Wang, Peng; Zhang, Jie; Su, Jianbin; Wang, Peng; Liu, Jun; Liu, Bing; Feng, Dongru; Wang, Jinfa; Wang, Hongbin

    2013-01-01

    The nongreen plastids, such as etioplasts, chromoplasts, etc., as well as chloroplasts, are all derived from proplastids in the meristem. To date, the Min system members in plants have been identified as regulators of FtsZ-ring placement, which are essential for the symmetrical division of chloroplasts. However, the regulation of FtsZ-ring placement in nongreen plastids is poorly understood. In this study, we investigated the division site placement of nongreen plastids by examining the etioplasts as representative in Arabidopsis Min system mutants. Surprisingly, the shape and number of etioplasts in cotyledons of arc3, arc11 and mcd1 mutants were similar to that observed in wild-type plants, whereas arc12 and parc6 mutants exhibited enlarged etioplasts that were reduced in number. In order to examine nongreen plastids in true leaves, we silenced the ALB3 gene in these Min system mutant backgrounds to produce immature chloroplasts without the thylakoidal network using virus induced gene silencing (VIGS). Interestingly, consistent with our observations in etioplasts, enlarged and fewer nongreen plastids were only detected in leaves of parc6 (VIGS-ALB3) and arc12 (VIGS-ALB3) plants. Further, the FtsZ-ring assembled properly at the midpoint in nongreen plastids of arc3, arc11 and mcd1 (VIGS-ALB3) plants, but organized into multiple rings in parc6 (VIGS-ALB3) and presented fragmented filaments in arc12 (VIGS-ALB3) plants, suggesting that division site placement in nongreen plastids requires fewer components of the plant Min system. Taken together, these results suggest that division site placement in nongreen plastids is different from that in chloroplasts. PMID:23936263

  11. High Temperature μSR Experiments for Accelerator Developments

    NASA Astrophysics Data System (ADS)

    Ohmori, Chihiro; Koda, Akihiro; Miyake, Yasuhiro; Nishiyama, Kusuo; Shimomura, Koichiro; Schnase, Alexander; Ezura, Eiji; Hara, Keigo; Hasegawa, Katsushi; Nomura, Masahiro; Shimada, Taihei; Takata, Koji; Tamura, Fumihiko; Toda, Makoto; Yamamoto, Masanobu; Yoshii, Masahito

    High temperature μSR is a powerful technique to study magnetic materials. In J-PARC accelerator synchrotrons, the Rapid Cycling Synchrotron (RCS) and Main Ring (MR), a unique magnetic alloy-loaded cavity is used for the beam acceleration and much higher field gradient has been achieved. Such high field gradient cavities made a compact RCS possible by reducing the length for beam acceleration. Now, further upgrades of the J-PARC, RF cavities with higher RF voltage and less power loss in the magnetic core are needed for the MR. For the improvements of the magnetic property of magnetic alloy core, the high temperature μSR (muon Spin Rotation/Relaxation) was used to investigate the crystallization process of the material. Based on the measurement results, the test production of the large ring cores of a magnetic alloy, FT3L, was tried. The FT3L is the magnetic alloy which has two times better performance than the present one, FT3M. For the FT3L production, the magnetic annealing is needed to control the easy-magnetized axis of the crystalline. After the success of the test production, a mass production was started in the industry to replace all existing cavities in the MR. The first 5-cell FT3L cavity is assembled for the bench test before the installation in the accelerator tunnel. By the new cavities, the total RF voltage of J-PARC MR will be doubled to increase the beam power for neutrino experiment. In future, the cavities will be also used for the RCS to increase the beam power beyond 1 MW.

  12. Satisfaction survey in general hospital personnel involved in blood transfusion: implementation of the ISO 9001: 2000 standard.

    PubMed

    Chord-Auger, S; Tron de Bouchony, E; Moll, M C; Boudart, D; Folléa, G

    2004-10-01

    As part of its policy of constant quality improvement, Etablissement francais du sang (EFS) des pays de la Loire (Pays de la Loire Regional Blood Transfusion Centre) carried out a satisfaction survey among the hospital personnel involved in prescribing and using immunohaematological tests and labile blood products (LBP). The polling tool selected by agreement between the Saint Nazaire's hospital management and Quality Assurance (QA) Department was a questionnaire that permitted item rating and free commentary. It addressed the personnel's perception of the quality of erythrocyte immunohaematological (EIH) testing and of the products administered, as well as their perception of the quality of communications with the local EFS. The questionnaire was sent to 26 physicians and 32 senior nurses in 15 hospital departments. The reply rate was 60% and expressed an 85% overall satisfaction level. Dissatisfaction causes were more specifically analysed, the main one involving LBP distribution in emergency situations. A joint undertaking by the EFS and the hospital led to the implementation of corrective measures, including the writing and implementation of a common standard operating procedure for emergency transfusion management. The results obtained demonstrated the feasibility of this type of survey and the interest, to a blood transfusion centre and the hospital personnel involved in transfusion, of assessing their very own perception of service quality.

  13. Pilot scale production of cellulolytic enzymes by Trichoderma reesei

    SciTech Connect

    Warzywoda, M.; Chevron, F.; Ferre, V.; Pourquie, J.

    1983-01-01

    The French substitute fuels program aims at the substitution of part of gasoline by methanol. In order to avoid phase separation of the gasoline-methanol blend, a cosolvant has to be added; one of the most efficient cosolvants is the mixture of acetone and butanol produced by anaerobic acetone-butanol fermentation. The Institut Francais du Petrole is thus implementing a research and development program on the production of acetone butanol from biomass, either sugar crops (fodder beets and Jerusalem artichoke) or lignocellulosic (corn stover and wheat straw). Production of sugars from lignocellulosics is a major part of this program. The enzymatic hydrolysis route, based on Trichoderma reesei cellulolytic enzymes, has been chosen since it does not cause any degradation of C/sub 5/ sugars which are good substrates of the acetone butanol fermentation. Efficient and cheap large-scale production of cellulolytic enzymes is thus a key step in this process. This paper reports on production of cellulases by Trichoderma reesei in a 3-m/sup 3/ pilot fermentor under conditions which should facilitate the scaling-up of the process. 7 references, 2 figures, 2 tables.

  14. Comparison of effectiveness of sub-slab ventilation systems for indoor radon mitigation: A numerical study; Comparaison a l`aide d`un outil numerique de l`efficacite des systemes de ventilation active du sol limitant la penetration du radon dans l`habitat

    SciTech Connect

    Bonnefous, Y.C. |; Gadgil, A.J.; Allard, F.

    1992-04-01

    The functioning of an active sub-slab ventilation system (SVS) has been studied successfully with the help of a previously evaluated numerical model. The parameters explored are the permeability of the sub-slab and the gravel placed beneath it, the amplitude of applied pressure at the installation point of the system and the functioning method: depressurization or pressurization. The mechanisms contributing to the success of the two systems are identified. This numerical study shows that the presence of a layer of gravel beneath the sub-slab considerably improves the performance of the SVS. Considered separately from the extremely permeable sub-slabs, the depressurization systems perform better than the pressurization systems. 17 refs. [Francais] Le fonctionnement des Systemes de Ventilation active du Sol (SVS) a ete etudie a l`aide d`un outil numerique precedemment evalue avec succes. Les parametres explores sont les permeabilites du sol et du gravier place sous plancher bas, l`amplitude de la pression appliquee au point d`installation du systeme, et le mode de fonctionnement: Depressurisation ou Pressurisation. Les mecanismes contribuant au succes des deux systemes sont identifies. Cette etude numerique montre que la presence d`une couche de gravier sous plancher bas ameliore de facon considerable les performances des SVS. Mis a part le cas des sols extremement permeables, les systemes de Depressurisation ont de meilleures performances que les systemes de Pressurisation. 17 refs.

  15. Development of a New Stratigraphic Trap Exploration Using Elastic-Wave Seismic Technology

    SciTech Connect

    Bryan DeVault

    2008-02-05

    Vecta acquired 9 square miles of 9-C seismic data in Mountrail County, North Dakota with the Mission Canyon shoreline as a primary target. Vecta contracted the Institute Francais du Petrole in order to co-develop a more rigorous multicomponent seismic interpretation product. The final interpretation was very unique in that it utilized not only the 9-C seismic data but also the new jointly developed software. A Mission Canyon anomaly was developed in 2006; however, it was of insufficient size to be a commercial target at the time. Therefore, Vecta analyzed the shear data for anisotropy within the Bakken formation and successfully reentered an abandoned producer within the project area and drilled a horizontal leg through the anomalous zones of the middle member of the Bakken formation. The well was open hole completed, swab tested, sand fraced, and swab tested some more. No shows of oil were ever seen from the Bakken formation, but the well yielded considerable amounts of formation water. The well has been abandoned as non-commercial. From the swab tests, one may conclude considerable permeability exists in the formation, thus confirming the utility of the shear wave to detect fractures within the targeted formation.

  16. Geologic and structural map of eastern Asia

    SciTech Connect

    Letouzey, J.; Sage, L.

    1986-07-01

    A synthesis of the onshore and offshore geologic data of eastern Asia, prepared by the Institut Francais du Petrole (IFP), has allowed the construction of geologic and structural maps for this region. These maps include three color sheets (scale = 1:2.5 million) and three plates of geologic and structural cross sections. Located between lat. 4/sup 0/ and 35/sup 0/N, and long. 106/sup 0/ and 132/sup 0/E, the maps cover the following geographic areas: East and South China Sea, Sulu Sea, West Philippine basin and onshore neighboring terrains, Kyushu and Ryukyu Islands, the China margin, Taiwan Island, Vietnam, North West Borneo, and the Philippines. The maps synthesize seismic interpretations, oil well data, geologic work in south Japan, Taiwan, Borneo, and the Philippines, and recent data published between 1976 and 1985. Twenty-four geologic cross sections (scale = 1:1.25 million, vertical exaggeration x 6) intersect ocean margins, important basins, and the different structural domains. They are based on seismic profiles, well data, and available onshore and offshore geologic data. These cross sections show basement composition and structures, different tectonic and sedimentary domains, and the structure and thickness of different sedimentary deposits (such as age, unconformities, and geologic structures). Maps and cross sections will be published in early 1987.

  17. Basin analysis in a Tertiary delta by numerical modeling: Mahakam case study (Indonesia)

    SciTech Connect

    Burrus, J.; Brosse, E. ); Grosjean, Y.; Choppin de Janvry, G.; Oudin, J.L. ); Bessereau, G. )

    1990-05-01

    The evolution of the Mahakam delta is discussed on the basis of a quantitative reconstruction using the two-dimensional TEMISPACK software developed at Institut Francais du Petrole. The following steps are achieved. (1) An east-west 80-km-long regional seismic line tied on wells is used to establish a depth-section divided in 25 chronostratigraphic levels, and 40 vertical columns. Fifteen different lithologies are distinguished (between shales and sandstones, with variable total organic carbon), as interpreted from well data and seismic profiles. (2) Porosity-depth relations derived from log-data are used to backstrip the section and reconstruct the past geometries. The development of geopressures is investigated after calibration of the permeabilities on the observed lithologies. In particular, the authors account for the small-scale variations of the sandshale ratio by introducing a high anisotropy of the permeabilities. The model is shown to reproduce well observations such as depth at which geopressures appear, and gradient of pressure in the overpressured zone. The simulations show that the geopressures essentially are controlled by the distribution of the sandy layers, and are due to compaction disequilibrium (3) The generation of hydrocarbons simulated by a kinetic model and the migration (separate phase flow) of hydrocarbons is discussed. Boundary conditions and underconstrained parameters, such as capillary forces, past heat flow, etc., are discussed on the basis of a sensitivity analysis.

  18. Modeling overpressures in sedimentary basins: Consequences for permeability and rheology of shales, and petroleum expulsion efficiency

    SciTech Connect

    Burrus, J.; Schneider, F.; Wolf, S. )

    1994-07-01

    The prediction of overpressures using Institut Francais du Petrole's 2-D numerical model TEMISPACK is applied to several provinces of the world. In the Paris basin, France, normally pressured Liassic shales are shown to have permeabilities around a microdarcy, independently confirmed by laboratory measurements. In contrast, in the Norway section of the North Sea, Williston Basin, Canada, Gulf Coast, and in the Mahakam delta, observed overpressures of 10-50 MPa are consistently modeled with shale permeabilities around 1-10 nanodarcys. This theoretical value fits well with the lowest permeability measured in compacted shales. For these basins, compaction disequilibrium was found to explain most (>85%) of the overpressures. The only exception was the Williston basin in which overpressures observed in the organic-rich Bakken shales are entirely due to hydrocarbon generation. In Mahakam delta, the rheology of shales is nonlinear, i.e., the strength of shales increases rapidly with death. Consequently, shale compaction cannot be described by the linear behavior often assumed in hydrology. In the absence of fault barriers, numerical simulations and geological evidence suggest that overpressured source rocks have low or very low expulsion efficiency, irrespective of their organic content. However, shales with a permeability on the order of a microdarcy do not hinder petroleum migration.

  19. IFP: Standing at the intersection between research and industry

    SciTech Connect

    Riviere, C.

    1995-08-01

    Since its formation in 1944, Institut Francais du Petrole (IFP) has pursued a wide range of research and development, training and information activities, servicing the complete chain of petroleum operations, ranging from exploration to the many uses of petroleum products. Standing at the intersection between research and industry, IFP combines basic research and applied industrial research. One of it roles is to contribute to renewing reserves by developing innovative technologies and to ensure the better technico-economic accessibility of discovered reserves. In exploration and reservoir engineering, the R&D program is mainly focused on subjects contributing to the development of methodologies and tools for a better assessment of petroleum resources of sedimentary basins, structural imaging, reservoir characterization, improved oil recovery, well productivity and a more intensive integration of the geosciences: geology/geophysics/reservoir engineering. Environmental protection is a subject of permanent concern at IFP. A part of the program is focused on the restoration of polluted environments. The determination to ensure the optimum dissemination of its scientific and technological patrimony in industry has justified the organization of large-scale industrial action. IFP represents an independent research center unrivaled in Europe. This situation has enabled it to emerge strongly as a leading figure in international scientific and technical circles.

  20. Manifestation of nonlinear elasticity in rock: Convincing evidence over large frequency and strain intervals from laboratory studies

    SciTech Connect

    Johnson, P.A. |; Rasolofosaon, P.N.J.

    1995-11-01

    Nonlinear elastic response in rock is established as a robust and representative characteristic of rock rather than a curiosity. This behavior is illustrated from a variety of experiments conducted over many orders of magnitude in strain and frequency. The evidence leads to a pattern of unifying behavior in rock: (1) Nonlinear response in rock is enormous; (2) the response takes place over a large frequency interval (dc--10{sup 6} Hz at least); (3) the response not only occurs, as is commonly appreciated, at large strains but also at small strains where nonlinear response and the manifestations of this behavior are commonly disregarded. Nonlinear response may manifest itself in a variety of manners, including a nonlinear stress{minus}strain relation (hysteretic/discrete memory), nonlinear dissipation, harmonic generation, and resonant peak shift, all of which are related. The experiments described include: quasistatic stress{minus}strain tests (strains of 10{sup -4}--10{sup -1} at frequencies near dc-1Hz); torsional oscillator experiments (strains of 10{sup {minus}4}--10{sup {minus}7}, frequencies between 0.1 and 100Hz); resonant bar experiments (strains of 10{sup {minus}4}--10{sup {minus}8}, frequencies between 10{sup 3} and 10{sup 4} Hz); and dynamic, propagating wave experiments (strains of 10{sup {minus}6}--10{sup {minus}9}, frequencies between 10{sup 3} and 10{sup 6} Hz). [Work supported by OBES/DOE through the University of California and the Institut Francais du Petrole.

  1. 2-D modeling of gas and overpressure generation in the Venture field (Canada)

    SciTech Connect

    Forbes, P.L.; Ungerer, P. ); Mudford, S. )

    1990-05-01

    Venture field is located in an overpressured zone of gas accumulations in a region that had low sedimentation rates over the last 80 m.y. This could support the hydrocarbon generation, rather than compaction disequilibrium, as the main cause for overpressuring. Study of these accumulations can be done using the IFP (Institut Francais du Petrole) THEMIS model, which integrates compactions, hydraulic fracturation, fluid flows, heat transfer, and formation and migration of hydrocarbons. A single phase basin scale model is constructed first to assess the input parameters related to the fluid-flow reconstruction. The permeability of faults is calibrated to fit the actual pressure distribution through the field. Permeability is found to be very low and allows a fit to the regional distribution of overpressuring. In a second step, a two-phase model, restricted to the field itself, is used to test parameters related to hydrocarbon and source rocks. Gas accumulations are effectively obtained in the reservoir units. Finally, the two-phase model is extended to the regional scale to check the parameters previously assessed. At this scale, the gas and overpressure distributions are found to fit those actually observed. Gas accumulations contribute slightly to overpressuring, which is better accounted for by compaction disequilibrium despite the low sedimentation rates. Generation in or close to the reservoir unit does not contribute significantly to the gas accumulations. However, gas sources are found in the underlying formations.

  2. Engelhard and IFP/Procatalyse set up worldwide catalysts venture

    SciTech Connect

    Hunter, D.

    1992-12-02

    The new joint venture between Engelhard (Iselin, N) and Procatalyse (Paris), jointly owned by process licenser Institut Francais de Petrole (IFP; Rueil Malmaison, France) and Rhone-Poulenc (RP; Paris), marks the latest episode in the worldwide catalyst industry's restructuring. The operation will combine Engelhard's catalyst line, apart from its fluid catalytic cracking (FCC) and emission catalysts, with Procatalyse's offering. To be launched at the beginning of 1993, the venture will have annual sales of about $75 million. Reforming catalysts will be the biggest part of the venture's lineup at the outset, making it number three in the US, behind UOP - which dominates the sector - and Criterion. IFP is starting to establish a presence in North America with its reforming technology. But flat gasoline demand and reductions on aromatics in gasoline limit requirements for new reforming units, comments one competitor. Although lower sulfur specifications are putting some new demand into the hydrodesulfurization (HDS) catalyst market, both partners play down their prospects. The sector, whose leaders are Akzo and Crtierion, is continuing to suffer from severe overcapacity. Procatalyse's HDS business is mainly linked to IFP licensees, while Engelhard is due to mothball its Salt Lake City HDS catalyst plant by year-end, transferring output to Elyria.

  3. Use of a combined personal computer and Rock-Eval in an integrated petroleum evaluation work station to estimate volumes of hydrocarbons generated and migrated in sedimentary basins

    SciTech Connect

    Espitalie, J.; Lafargue, E.; Drouet, S.

    1989-09-01

    A petroleum evaluation work station consisting in a modified Rock-Eval apparatus connected to an IBM personal computer has been designed at Institut Francais du petrole to estimate the amount of hydrocarbon generated and migrated in sedimentary basins. The work-station is provided with specific software for Rock-Eval data analysis, quick determination of kinetic parameters (Optim model), and quantitative hydrocarbon generation (Matoil model). Along with the classical Rock-Eval parameters (S{sub 0}, S{sub 1}, S{sub 2}, TOC, and T{sub max}), new parameters concerning the source rocks, such as the transformation efficiency ratio (TER), the migration efficiency ration (MER), and the initial generation capacity (IGC), are defined. These new parameters combined with geological data give access to a rapid volumetric estimation (in 10{sup 6}MT/km{sup 2}) of hydrocarbon generation and migration in the studied area. These data can be displayed on different specific maps for rapid visualization. This work station has been successfully used in the Paris and Aquitaine basins, making possible a better assessment of their petroleum potential. The petroleum evaluation work station appears to be a very valuable tool that can be used in the different phases of exploration in a sedimentary basin.

  4. A two-dimensional regional basin model of Williston basin hydrocarbon systems

    SciTech Connect

    Burrus, J.; Wolf, S.; Doligez, B.

    1996-02-01

    Institut Francais du Petrole`s two-dimensional model, TEMISPACK, is used to discuss the functioning of petroleum systems in the Williston basin along a 330-km-long section, focusing on four regional source intervals: Ordovician Yeoman formation, Lower Devonian Winnipegosis Formation, Upper Devonian-Lower Mississippian Bakken Formation, and Mississippian Lodgepole formation. Thermal history calibration against present temperature and source rock maturity profiles suggests that the Williston basin can be divided into a region of constant heat flow of about 55 mW/m{sup 2} away from the Nesson anticline, and a region of higher heat flow and enhanced thermal maturity in the vicinity of the Nesson anticline. Original kinetic parameters used in the calibration were derived for each of the four source rocks from Rock-Eval yield curves. Bakken overpressures are entirely due to oil generation, not compaction disequilibrium. Very low Bakken vertical permeabilities range from 0.01 to 0.001 and are matched against observed overpressures, whereas Bakken porosities based on the model and confirmed by measurements are inferred to be also unusually low, around 3%.

  5. Combined modeling approaches as an aid to structural interpretation

    SciTech Connect

    Richert, J.P. ); Coletta, B. )

    1993-09-01

    Many exploration failures can be attributed to a misunderstanding of poorly expressed seismic data. To aid tectonic and structural interpretation, a combined modeling approach has been attempted in a joint research program between Elf Aquitaine Production, TOTAL, AGIP, and Institut Francais du Petrole. This approach involves analog and numerical modeling constrained by field geology models and examples. Well-studied field geology examples provide defined three-dimensional (3-D) geometries and provide clues about the mechanical history of deformation. However, the field models give a static image of the finite strain, and the different stages of deformation remain conjectural. Analog physical modeling using sand, glass powder, and silicone putty elucidates the kinematics and, to some extent, the mechanism of deformation. However, the oversimplified rheology of modeling materials implies analogy limitations and precludes perfect simulation of all natural examples. Numerical modeling, based on finite or distinct elements methods, permits quantification of stress and strain at each step of the deformation. It also offers a larger range of rheological parameters; however, those parameters are difficult to precisely equate to slow deformation on a geological time scale. Thus, each technique has its respective advantages and limitations, but the combination of the three approaches can help to define 3-D geometries and kinematics, and to evaluate the mechanism of deformation, which can be applied to the structural interpretation of seismic data. Such an interdisciplinary approach has been tested for various tectonic regimes, and examples will be given to illustrate this method of investigation.

  6. An overview of multiphase helicoaxial pumps

    SciTech Connect

    Falcimaigne, J.

    1996-02-01

    The helicoaxial concept developed by the Inst. Francais du Petrole (IFP) is one of two types of multiphase pumps extensively tested on fields and now used commercially. Helicoaxial pumps are rotodynamic turbomachines that are, in fact, hybrids between pumps and axial compressors. Helicoaxial pumps are based on special patented hydraulics designed to limit the phase separation that occurs in two-phase flow with conventional centrifugal pumps that produce a tremendous head loss. Developers have carried out extensive research and testing on actual production sites to develop helicoaxial pumping. The favorable results obtained so far confirm the soundness and versatility of the technology over a wide range of operating conditions. Helicoaxial pumps cover a larger domain of application than anticipated some years ago. They can be used with high gas volume fraction (94 to 95%) and/or low suction pressures. The pumps` inherent low weight should make them particularly attractive for large flow rates and offshore operations. Helicoaxial pumps are reliable products, technically and commercially read for field deployment.

  7. France: late abortion.

    PubMed

    Gaudry, D; Sadan, G

    1989-01-01

    In France, under the terms of a law passed by Parliament in 1975, a woman may have an abortion up to 12 weeks of pregnancy if she is a French resident and, in the event that she is a minor, she has parental consent. The woman must also have 2 medical consultations, a week apart. The woman is reimbursed by the state up to 70% of the cost of the abortion. After 12 weeks, abortion, except for therapeutic abortion, under the terms of Article 317 of the Criminal Code, is a crime, punishable by 6 months to 10 years in prison, a fine of between 1800 and 250,000 Francs, and loss of professional license. Moreover, Article 647 of the Health Code bans any advertising, incitement or propaganda for abortion or abortion-inducing products. Many French women go to Britain or Holland for abortions after 12 weeks, but they face the financial burden of traveling as well as the difficulties of getting help in a strange country and the stigma of having done something illegal. The Mouvement Francais pour le Planning Familial, which won the legalization of contraception in 1967, is now fighting for legal abortion as well as the distribution of information about sexuality, contraception, and abortion in the schools. 2 charges of incitement to abortion have been brought against the organization.

  8. Interdigital H -mode drift-tube linac design with alternative phase focusing for muon linac

    NASA Astrophysics Data System (ADS)

    Otani, M.; Mibe, T.; Yoshida, M.; Hasegawa, K.; Kondo, Y.; Hayashizaki, N.; Iwashita, Y.; Iwata, Y.; Kitamura, R.; Saito, N.

    2016-04-01

    We have developed an interdigital H-mode (IH) drift-tube linac (DTL) design with an alternative phase focusing (APF) scheme for a muon linac, in order to measure the anomalous magnetic moment and electric dipole moment (EDM) of muons at the Japan Proton Accelerator Research Complex (J-PARC). The IH-DTL accelerates muons from β =v /c =0.08 to 0.28 at an operational frequency of 324 MHz. The output beam emittances are calculated as 0.315 π and 0.195 π mm mrad in the horizontal and vertical directions, respectively, which satisfies the experimental requirement.

  9. Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131.

    PubMed

    Johnson, James R; Porter, Stephen B; Thuras, Paul; Johnson, Timothy J; Price, Lance B; Tchesnokova, Veronika; Sokurenko, Evgeni V

    2015-11-01

    Minimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of the H30 subclone within Escherichia coli sequence type 131 than among 48 other fluoroquinolone-resistant E. coli isolates. This MBC difference, which was not explained by ciprofloxacin MICs, gyrA, parC, and parE mutations, the presence of aac(6')-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of the H30 sequence type 131 subclone.

  10. Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains.

    PubMed

    Neemuchwala, Alefiya; Teatero, Sarah; Patel, Samir N; Fittipaldi, Nahuel

    2016-01-01

    Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen. PMID:27559344

  11. Development of a silicon micro-strip detector for tracking high intensity secondary beams

    NASA Astrophysics Data System (ADS)

    Kiuchi, R.; Asano, H.; Hasegawa, S.; Honda, R.; Ichikawa, Y.; Imai, K.; Joo, C. W.; Nakazawa, K.; Sako, H.; Sato, S.; Shirotori, K.; Sugimura, H.; Tanida, K.; Watabe, T.

    2014-11-01

    A single-sided silicon micro-strip detector (SSD) has been developed as a tracking detector for hadron experiments at J-PARC where secondary meson beams with intensities of up to 108 Hz are available. The performance of the detector has been investigated and verified in a series of test beam experiments in the years 2009-2011. The hole mobility was deduced from the analysis of cluster events. The beam rate dependence was measured in terms of timing resolution, signal-to-noise ratio, and hit efficiency. This paper describes the detector with its read-out system, details of the test experiments, and discusses the performance achieved.

  12. Future long-baseline neutrino oscillations: View from Asia

    SciTech Connect

    Hayato, Yoshinari

    2015-07-15

    Accelerator based long-baseline neutrino oscillation experiments have been playing important roles in revealing the nature of neutrinos. However, it turned out that the current experiments are not sufficient to study two major remaining problems, the CP violation in the lepton sector and the mass hierarchy of neutrinos. Therefore, several new experiments have been proposed. Among of them, two accelerator based long-baseline neutrino oscillation experiments, the J-PARC neutrino beam and Hyper-Kamiokande, and MOMENT, have been proposed in Asia. These two projects are reviewed in this article.

  13. Precision neutron flux measurement with a neutron beam monitor

    NASA Astrophysics Data System (ADS)

    Ino, T.; Otono, H.; Mishima, K.; Yamada, T.

    2014-07-01

    Neutron beam monitors are regularly used in various neutron beam experiments to compare two or more sets of data taken in different experimental conditions. A neutron lifetime experiment at BL05, the NOP beamline, in J-PARC requires to monitor the initial neutron intensity with an precision of 0.1% to measure the neutron lifetime with the same accuracy. The performance of a thin 3He gas neutron beam monitor used for the experiment was studied to estimate the systematic uncertainties in the neutron lifetime measurement.

  14. Spin and Beam Dynamics in the Muon (g - 2) Experiments

    NASA Astrophysics Data System (ADS)

    Semertzidis, Yannis K.

    2016-09-01

    A number of recent advances in the Physics of the Muon (g - 2) experiments are described outlining the expectations of future improvements of the statistical and systematic errors of the technique. A comparison between the spin and beam dynamics of the two muon (g - 2) experiments under preparation at FNAL and at J-PARC shows that they are both well under control. It may be possible to use magnetic focusing for the FNAL experiment, especially if a decision is made to run with negative muons. Finally, a polarized proton beam could be used to measure the B-field in case of magnetic focusing.

  15. Sivers effect in Drell-Yan processes

    SciTech Connect

    Anselmino, M.; Boglione, M.; Melis, S.; Prokudin, A.; D'Alesio, U.; Murgia, F.

    2009-03-01

    The Sivers distributions recently extracted from semi-inclusive deep inelastic scattering data [M. Anselmino et al., Eur. Phys. J. A 39, 89 (2009)] are used to compute estimates for Sivers asymmetries in Drell-Yan processes which are being planned at several facilities (RHIC, COMPASS, J-PARC, PAX, PANDA, NICA (JINR) and SPASCHARM (IHEP)). Most of these asymmetries turn out to be large and could allow a clear test of the predicted sign change of the Sivers distributions when active in SIDIS and Drell-Yan processes. This is regarded as a fundamental test of our understanding, within QCD and the factorization scheme, of single spin asymmetries.

  16. Verification of a neutronic code for transient analysis in reactors with Hex-z geometry

    SciTech Connect

    Gonzalez-Pintor, S.; Verdu, G.; Ginestar, D.

    2012-07-01

    Due to the geometry of the fuel bundles, to simulate reactors such as VVER reactors it is necessary to develop methods that can deal with hexagonal prisms as basic elements of the spatial discretization. The main features of a code based on a high order finite element method for the spatial discretization of the neutron diffusion equation and an implicit difference method for the time discretization of this equation are presented and the performance of the code is tested solving the first exercise of the AER transient benchmark. The obtained results are compared with the reference results of the benchmark and with the results provided by PARCS code. (authors)

  17. Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains

    PubMed Central

    Teatero, Sarah; Patel, Samir N.

    2016-01-01

    Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide. Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America. We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection. Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen. PMID:27559344

  18. Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli

    PubMed Central

    Johnston, Brian; Kuskowski, Michael A.; Sokurenko, Evgeni V.; Tchesnokova, Veronika

    2015-01-01

    The recent expansion of the H30 subclone of Escherichia coli sequence type 131 (ST131) and its CTX-M-15-associated H30Rx subset remains unexplained. Although ST131 H30 typically exhibits fluoroquinolone resistance, so do multiple other E. coli lineages that have not expanded similarly. To determine whether H30 isolates have more intense fluoroquinolone resistance than other fluoroquinolone-resistant E. coli isolates and to identify possible mechanisms, we determined the MICs for four fluoroquinolones (ciprofloxacin, levofloxacin, moxifloxacin, and norfloxacin) among 89 well-characterized, genetically diverse fluoroquinolone-resistant E. coli isolates (48 non-H30 and 41 H30 [23 H30Rx and 18 H30 non-Rx]). We compared the MICs with the H30 and H30Rx status, the presence/number of nonsynonymous mutations in gyrA, parC, and parE, the presence of aac(6′)-1b-cr (an aminoglycoside/fluoroquinolone agent-modifying enzyme), and the efflux pump activity (measured as organic solvent tolerance [OST]). Among 1,518 recent E. coli clinical isolates, ST131 H30 predominated clonally, both overall and among the fluoroquinolone-resistant isolates. Among the 89 study isolates, compared with non-H30 isolates, H30 isolates exhibited categorically higher MICs for all four fluoroquinolone agents, higher absolute ciprofloxacin and norfloxacin MICs, more nonsynonymous mutations in gyrA, parC, and parE (specifically gyrA D87N, parC E84V, and parE I529L), and a numerically higher prevalence of (H30Rx-associated) aac(6′)-1b-cr but lower OST scores. All putative resistance mechanisms were significantly associated with the MICs [for aac(6′)-1b-cr: ciprofloxacin and norfloxacin only]. parC D87N corresponded with ST131 H30 and parE I529L with ST131 generally. Thus, more intense fluoroquinolone resistance may provide ST131 H30, especially H30Rx [if aac(6′)-1b-cr positive], with subtle fitness advantages over other fluoroquinolone-resistant E. coli strains. This urges both parsimonious

  19. Global-local visual processing impacts risk taking behaviors, but only at first.

    PubMed

    Lim, Stephen Wee Hun; Yuen, Alexander Y L; Tong, Eddie M W

    2015-01-01

    We investigated the impact of early visual processing on decision-making during unpredictable, risky situations. Participants undertook Navon's (1977) task and attended to either global letters or local letters only, following which they completed the Balloon Analogue Risk Task (BART). It was observed that global-focused individuals made more balloon pumps during the BART (i.e., took more risk), whereas local-focused individuals took less risk, albeit only initially. The theory of predictive and reactive control systems (PARCS) provides an excellent account of the data. Implications and future directions are discussed. PMID:26379586

  20. Lattice physics capabilities of the SCALE code system using TRITON

    SciTech Connect

    DeHart, M. D.

    2006-07-01

    This paper describes ongoing calculations used to validate the TRITON depletion module in SCALE for light water reactor (LWR) fuel lattices. TRITON has been developed to provide improved resolution for lattice physics mixed-oxide fuel assemblies as programs to burn such fuel in the United States begin to come online. Results are provided for coupled TRITON/PARCS analyses of an LWR core in which TRITON was employed for generation of appropriately weighted few-group nodal cross-sectional sets for use in core-level calculations using PARCS. Additional results are provided for code-to-code comparisons for TRITON and a suite of other depletion packages in the modeling of a conceptual next-generation boiling water reactor fuel assembly design. Results indicate that the set of SCALE functional modules used within TRITON provide an accurate means for lattice physics calculations. Because the transport solution within TRITON provides a generalized-geometry capability, this capability is extensible to a wide variety of non-traditional and advanced fuel assembly designs. (authors)

  1. INTERCOMPARISON OF RESULTS FOR A PWR ROD EJECTION ACCIDENT

    SciTech Connect

    DIAMOND,D.J.; ARONSON,A.; JO,J.; AVVAKUMOV,A.; MALOFEEV,V.; SIDOROV,V.; FERRARESI,P.; GOUIN,C.; ANIEL,S.; ROYER,M.E.

    1999-10-01

    This study is part of an overall program to understand the uncertainty in best-estimate calculations of the local fuel enthalpy during the rod ejection accident. Local fuel enthalpy is used as the acceptance criterion for this design-basis event and can also be used to estimate fuel damage for the purpose of determining radiological consequences. The study used results from neutron kinetics models in PARCS, BARS, and CRONOS2, codes developed in the US, the Russian Federation, and France, respectively. Since BARS uses a heterogeneous representation of the fuel assembly as opposed to the homogeneous representations in PARCS and CRONOS, the effect of the intercomparison was primarily to compare different intra-assembly models. Quantitative comparisons for core power, reactivity, assembly fuel enthalpy and pin power were carried out. In general the agreement between methods was very good providing additional confidence in the codes and providing a starting point for a quantitative assessment of the uncertainty in calculated fuel enthalpy using best-estimate methods.

  2. Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan.

    PubMed

    Matayoshi, Masanao; Kitano, Takashi; Sasaki, Tetsu; Nakamura, Masaji

    2015-06-01

    A total of 349 Salmonella enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) strains, which were isolated between 2008 and 2012 from 349 pigs at two slaughterhouses in Okinawa Prefecture, Japan, were investigated for antimicrobial susceptibility and the presence of antimicrobial resistance genes. All isolates were resistant to at least four antimicrobial agents. The antimicrobial agents for which isolates showed a high incidence of resistance were as follows: ampicillin (100%) and streptomycin (100%), followed by gentamicin (99.7%), oxytetracycline (99.7%), sulfamethoxazole/trimethoprim (99.4%), nalidixic acid (40.1%) and oxolinic acid (40.1%). All isolates were sensitive to cefuroxime, ceftiofur, colistin, fosfomycin, enrofloxacin, orbifloxacin and danofloxacin. The predominant resistance phenotypes and genotypes were: resistance to ampicillin, streptomycin, gentamicin, oxytetracycline and sulfamethoxazole/trimethoprim (58.5%, 204/349) and blaTEM-strA-strB-aadA1-aadA2-aacC2-tet (B)-sul1-sul2-dhfrXII-dhfrXIII (36.1%, 126/349). The quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE of the quinolone-resistant isolates (n=12) showed amino acid substitutions of Ser-83→Phe or Asp-87→Tyr in GyrA and Ser-107→Ala in ParC. To our knowledge, this is the first report on the molecular characterization of antimicrobial resistance among S. Choleraesuis strains in Japan.

  3. [Effect of Low-concentration Ciprofloxacin on the Nitrification and Nitrifying Microorganisms of Biofilms in Biological Aerated Filter].

    PubMed

    He, Shi; Gu, Chao-chao; Wei, Xin; Huang, Sheng-lin; Liu, Zhen-hong; Xue, Gang; Gao, Pin

    2016-04-15

    Effect of low-concentration ciprofloxacin (CIP) on nitrification and nitrifying microorganisms of biofilms was studied in biological aerated filters (BAF). Quantitative PCR (qPCR) was used to determine the abundance variance of four ciprofloxacin resistance genes (CIP-ARGs) during nitrification in biofilms. The correlations between the abundances of CIP-ARGs and nitrifying microorganisms were also discussed. The results showed that CIP had little influence on the ammonium oxidation process of biofilm microorganisms, whereas inhibition of the nitrite oxidation process was found. The quantitative results of ammonium-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB) including Nitrobacter and Nitrospira indicated that the inhibition on the transformation of nitrite was resulted from the inhibition on Nitrobacter and Nitrospira. In addition, little influence of CIP on the relative abundance of aac and qepA in biofilms was found, but the influence on parC and oqxB was great. The abundance of Nitrotacter exhibited significant positive correlation with the abundance of parC. Similar significant correlation was also found between the abundances of Nitrospira and oqxB. It could be speculated that the genetic elements of different nitrifying microorganisms in biofilms possibly carried CIP-ARGs. PMID:27548973

  4. Molecular characterisation of the clonal emergence of high-level ciprofloxacin-monoresistant Haemophilus influenzae in the Region of Southern Denmark.

    PubMed

    Fuursted, Kurt; Hartmeyer, Gitte Nyvang; Stegger, Marc; Andersen, Paal Skytt; Justesen, Ulrik Stenz

    2016-06-01

    Haemophilus influenzae is an important human pathogen usually susceptible to quinolones. Here we report the emergence of high-level ciprofloxacin-monoresistant H. influenzae in the Region of Southern Denmark. Four isolates were collected for phenotypic and molecular characterisation using whole-genome sequencing (WGS). During an 18-month period, the occurrence of high-level ciprofloxacin-monoresistant H. influenzae in patients aged 1-77 years from sputum, ear and eye samples was detected. An epidemiological link between the patients could not be identified. The isolates were non-encapsulated, biotype III and were demonstrated by WGS to be clonal belonging to a single clade with an unknown multilocus sequence type (double-locus variant of ST196). The antibiogram demonstrated that they were all monoresistant to ciprofloxacin with a minimum inhibitory concentration (MIC) >32mg/L. In silico resistome analysis revealed identical, both previously characterised and novel, putative resistance-related mutations in gyrA (S84L and D88N), parC (K20R, S84I, D356A or T356A, and M481I) and parE (E151K, I159A, D420N and S599A) in all isolates. The isolates were otherwise negative for any resistance genes. This is the first description of the clonal emergence of high-level monoresistant H. influenzae due to amino acid substitutions in gyrA, parC and parE. PMID:27436470

  5. Molecular characterisation of the clonal emergence of high-level ciprofloxacin-monoresistant Haemophilus influenzae in the Region of Southern Denmark.

    PubMed

    Fuursted, Kurt; Hartmeyer, Gitte Nyvang; Stegger, Marc; Andersen, Paal Skytt; Justesen, Ulrik Stenz

    2016-06-01

    Haemophilus influenzae is an important human pathogen usually susceptible to quinolones. Here we report the emergence of high-level ciprofloxacin-monoresistant H. influenzae in the Region of Southern Denmark. Four isolates were collected for phenotypic and molecular characterisation using whole-genome sequencing (WGS). During an 18-month period, the occurrence of high-level ciprofloxacin-monoresistant H. influenzae in patients aged 1-77 years from sputum, ear and eye samples was detected. An epidemiological link between the patients could not be identified. The isolates were non-encapsulated, biotype III and were demonstrated by WGS to be clonal belonging to a single clade with an unknown multilocus sequence type (double-locus variant of ST196). The antibiogram demonstrated that they were all monoresistant to ciprofloxacin with a minimum inhibitory concentration (MIC) >32mg/L. In silico resistome analysis revealed identical, both previously characterised and novel, putative resistance-related mutations in gyrA (S84L and D88N), parC (K20R, S84I, D356A or T356A, and M481I) and parE (E151K, I159A, D420N and S599A) in all isolates. The isolates were otherwise negative for any resistance genes. This is the first description of the clonal emergence of high-level monoresistant H. influenzae due to amino acid substitutions in gyrA, parC and parE.

  6. Incidence of quinolone resistance in strains of Salmonella isolated from poultry, cattle and pigs in Germany between 1998 and 2001.

    PubMed

    Malorny, B; Schroeter, A; Guerra, B; Helmuth, R

    2003-11-22

    This paper reports the susceptibility to the quinolone nalidixic acid and the fluoroquinolone ciprofloxacin of 14,514 strains of Salmonella isolated in Germany from poultry, cattle and pigs between 1998 and 2001. Quinolone-resistant salmonellae were most frequently isolated from poultry, with a prevalence of 10.2 to 16.8 per cent. Poultry-associated serotypes, such as Salmonella Paratyphi B (d-tartrate positive), Salmonella Hadar and Salmonella Virchow, had the highest prevalence of quinolone resistance, ranging between 35 and 74 per cent. All the nalidixic acid-resistant strains also had a reduced susceptibility to ciprofloxacin, with minimum inhibitory concentrations (MICS) of 0.125 to 2 microg/ml. A comparison of the MICS for ciprofloxacin of the strains of these poultry-associated serotypes and Salmonella Enteritidis phage type 4 isolated in 1998/99 and 2000/01 indicated that there had been a shift towards higher MIC values of up to 2 microg/ml. The quinolone resistance-determining region (QRDR) of the gyrA gene and the homologue region of the parC gene of 31 selected strains were sequenced. Several different amino acid changes were observed in gyrA of the quinolone-resistant isolates at positions 83 and 87, but no substitutions were observed in parC.

  7. Fluoroquinolone Resistance in Penicillin-resistant Streptococcus pneumoniae Clones, Spain

    PubMed Central

    Balsalobre, Luz; Ardanuy, Carmen; Fenoll, Asunción; Pérez-Trallero, Emilio; Liñares, Josefina

    2004-01-01

    Among 2,882 Streptococcus pneumoniae sent to the Spanish Reference Laboratory during 2002, 75 (2.6%) were ciprofloxacin-resistant. Resistance was associated with older patients (3.9% in adults and 7.2% in patients >65 years of age), with isolation from noninvasive sites (4.3% vs. 1.0%), and with penicillin and macrolide resistance. Among 14 low-level resistant (MIC 4–8 µg/mL) strains, 1 had a fluoroquinolone efflux phenotype, and 13 showed single ParC changes. The 61 high-level ciprofloxacin-resistant (MIC >16 µg/mL) strains showed either two or three changes at ParC, ParE, and GyrA. Resistance was acquired either by point mutation (70 strains) or by recombination with viridans streptococci (4 strains) at the topoisomerase II genes. Although 36 pulsed-field gel electrophoresis patterns were observed, 5 international multiresistant clones (Spain23F-1, Spain6B-2, Spain9V-3, Spain14-5 and Sweden15A-25) accounted for 35 (46.7%) of the ciprofloxacin-resistant strains. Continuous surveillance is needed to prevent the dissemination of these clones. PMID:15504260

  8. Resistance phenotypes and genotypes among multiple-antimicrobial-resistant Salmonella enterica subspecies enterica serovar Choleraesuis strains isolated between 2008 and 2012 from slaughter pigs in Okinawa Prefecture, Japan

    PubMed Central

    MATAYOSHI, Masanao; KITANO, Takashi; SASAKI, Tetsu; NAKAMURA, Masaji

    2015-01-01

    A total of 349 Salmonella enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) strains, which were isolated between 2008 and 2012 from 349 pigs at two slaughterhouses in Okinawa Prefecture, Japan, were investigated for antimicrobial susceptibility and the presence of antimicrobial resistance genes. All isolates were resistant to at least four antimicrobial agents. The antimicrobial agents for which isolates showed a high incidence of resistance were as follows: ampicillin (100%) and streptomycin (100%), followed by gentamicin (99.7%), oxytetracycline (99.7%), sulfamethoxazole/trimethoprim (99.4%), nalidixic acid (40.1%) and oxolinic acid (40.1%). All isolates were sensitive to cefuroxime, ceftiofur, colistin, fosfomycin, enrofloxacin, orbifloxacin and danofloxacin. The predominant resistance phenotypes and genotypes were: resistance to ampicillin, streptomycin, gentamicin, oxytetracycline and sulfamethoxazole/trimethoprim (58.5%, 204/349) and blaTEM-strA-strB-aadA1-aadA2-aacC2-tet (B)-sul1-sul2-dhfrXII-dhfrXIII (36.1%, 126/349). The quinolone resistance-determining regions (QRDRs) of gyrA, gyrB, parC and parE of the quinolone-resistant isolates (n=12) showed amino acid substitutions of Ser-83→Phe or Asp-87→Tyr in GyrA and Ser-107→Ala in ParC. To our knowledge, this is the first report on the molecular characterization of antimicrobial resistance among S. Choleraesuis strains in Japan. PMID:25715779

  9. Elementary Particle Physics and High Energy Phenomena: Final Report for FY2010-13

    SciTech Connect

    Cumalat, John P.; de Alwis, Senarath P.; DeGrand, Thomas A.; DeWolfe, Oliver; Ford, William T.; Hasenfratz, Anna; Mahanthappa, K. T.; Marino, Alysia D.; Nauenberg, Uriel; Smith, James G.; Stenson, Kevin; Wagner, Stephen R.; Zimmerman, Eric D.

    2013-06-27

    The work under this grant consists of experimental, theoretical, and phenomenological research on the fundamental properties of high energy subnuclear particles. The work is conducted at the University of Colorado, the European Organization for Nuclear Research (CERN), the Japan Proton Accelerator Research Complex (J-PARC), Fermi National Accelerator Laboratory (FNAL), SLAC National Accelerator Laboratory (SLAC), Los Alamos National Laboratory (LANL), and other facilities, employing neutrino-beam experiments, test beams of various particles, and proton-proton collider experiments. It emphasizes mass generation and symmetry-breaking, neutrino oscillations, bottom particle production and decay, detector development, supergravity, supersymmetry, superstrings, quantum chromodynamics, nonequilibrium statistical mechanics, cosmology, phase transitions, lattice gauge theory, and anomaly-free theories. The goals are to improve our understanding of the basic building blocks of matter and their interactions. Data from the Large Hadron Collider at CERN have revealed new interactions responsible for particle mass, and perhaps will lead to a more unified picture of the forces among elementary material constituents. To this end our research includes searches for manifestations of theories such as supersymmetry and new gauge bosons, as well as the production and decay of heavy-flavored quarks. Our current work at J-PARC, and future work at new facilities currently under conceptual design, investigate the specifics of how the neutrinos change flavor. The research is integrated with the training of students at all university levels, benefiting both the manpower and intellectual base for future technologies.

  10. T0 chopper developed at KEK

    NASA Astrophysics Data System (ADS)

    Itoh, Shinichi; Ueno, Kenji; Ohkubo, Ryuji; Sagehashi, Hidenori; Funahashi, Yoshisato; Yokoo, Tetsuya

    2012-01-01

    We developed a T0 chopper rotating at 100 Hz at the High Energy Accelerator Research Organization (KEK) for the reduction of background noise in neutron scattering experiments at the Japan Proton Accelerator Research Complex (J-PARC). The T0 chopper consists of a rotor of 120 kg made from Inconel X750, supported by mechanical bearings in vacuum. The motor is located outside the vacuum and the rotation is transmitted into vacuum through magnetic seals. The motor should rotate in synchronization with the production timing of pulsed neutrons. The rotational fluctuations and running time were in good agreement with the specifications, i.e., phase control accuracy of less than 5 μs and running time of more than 4000 h without changing any component. A semi-auto installation mechanism was developed for installing under the shielding and for maintenance purposes. Based on the result of the development, actual machines were made for the neutron beamlines at J-PARC. We successfully reduced the background noise to 1/30 at neutron energies near 500 meV.

  11. Molecular characterization of tetracycline- and quinolone-resistant Aeromonas salmonicida isolated in Korea

    PubMed Central

    Kim, Ji Hyung; Hwang, Sun Young; Son, Jee Soo; Han, Jee Eun; Jun, Jin Woo; Shin, Sang Phil; Choresca, Casiano; Choi, Yun Jaie; Park, Yong Ho

    2011-01-01

    The antibiotic resistance of 16 Aeromonas (A.) salmonicida strains isolated from diseased fish and environmental samples in Korea from 2006 to 2009 were investigated in this study. Tetracycline or quinolone resistance was observed in eight and 16 of the isolates, respectively, based on the measured minimal inhibitory concentrations. Among the tetracycline-resistant strains, seven of the isolates harbored tetA gene and one isolate harbored tetE gene. Additionally, quinolone-resistance determining regions (QRDRs) consisting of the gyrA and parC genes were amplified and sequenced. Among the quinolone-resistant A. salmonicida strains, 15 harbored point mutations in the gyrA codon 83 which were responsible for the corresponding amino acid substitutions of Ser83→Arg83 or Ser83→Asn83. We detected no point mutations in other QRDRs, such as gyrA codons 87 and 92, and parC codons 80 and 84. Genetic similarity was assessed via pulsed-field gel electrophoresis, and the results indicated high clonality among the Korean antibiotic-resistant strains of A. salmonicida. PMID:21368562

  12. 3-D viscous flow CFD analysis of the propeller effect on an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1993-01-01

    The time-marching Navier-Stokes code PARC3D was used to study the 3D viscous flow associated with an advanced ducted propeller subsonic inlet at take-off operating conditions. At a free stream Mach number of 0.2, experimental data for the inlet-with-propeller test model indicated that the airflow was attached on the cowl windward lip at an angle of attack of 25 deg became unstable at 29 deg, and separated at 30 deg. An experimental study with a similar inlet and without propeller (through-flow) indicated that flow separation occurred at an angle of attack a few degrees below the value observed when the inlet was tested with the propeller, indicating the propeller's favorable effect on inlet performance. In the present numerical study, flow blockage analogous to the propeller was modeled via a PARC3D computational boundary condition (BC), the 'screen BC', based on 1-1/2 dimension actuator disk theory. The application of the screen BC in this numerical study provided results similar to those of past experimental efforts in which either the blockage device or the propeller was used.

  13. Status and neutrino oscillation physics potential of the Hyper-Kamiokande Project in Japan

    NASA Astrophysics Data System (ADS)

    De Rosa, Gianfranca; Hyper-Kamiokande ProtoCollaboration

    2016-05-01

    Hyper-Kamiokande (Hyper-K), a proposed one-megaton water Cherenkov detector to be built in Japan, is the logical continuation of the highly successful program of neutrino (astro) physics and proton decay using the water Cherenkov technique. In its baseline design, the Hyper-K detector consists of two cylindrical tanks lying side-by-side, the outer dimensions of each tank being 48m × 54m × 250m. The inner detector region will be instrumented with 99,000 20-inch photo-sensors. An international proto-collaboration has been intensively working on the R&D of key components such as optimization of cavern, tank construction, development of high performance photo-sensors, design of new near detectors and improvements to the J-PARC neutrino beam. Hyper-K will study the CP asymmetry in neutrino oscillations using the neutrino and anti-neutrino beams produced at J-PARC. With an exposure of 7.5 MW × 107 seconds, CP violating parameter delta can be measured to better than 19 degrees at all values of delta, and CP violation can be detected with more than 3 sigma significance for 76% of the values. An overview of the status of project and the studies of the sensitivity of this detector to physics quantities governing neutrino oscillation is presented.

  14. Experimental and analytical study of close-coupled ventral nozzles for ASTOVL aircraft

    NASA Technical Reports Server (NTRS)

    Mcardle, Jack G.; Smith, C. Frederic

    1990-01-01

    Flow in a generic ventral nozzle system was studied experimentally and analytically with a block version of the PARC3D computational fluid dynamics program (a full Navier-Stokes equation solver) in order to evaluate the program's ability to predict system performance and internal flow patterns. For the experimental work a one-third-size model tailpipe with a single large rectangular ventral nozzle mounted normal to the tailpipe axis was tested with unheated air at steady-state pressure ratios up to 4.0. The end of the tailpipe was closed to simulate a blocked exhaust nozzle. Measurements showed about 5 1/2 percent flow-turning loss, reasonable nozzle performance coefficients, and a significant aftward axial component of thrust due to flow turning loss, reasonable nozzle performance coefficients, and a significant aftward axial component of thrust due to flow turning more than 90 deg. Flow behavior into and through the ventral duct is discussed and illustrated with paint streak flow visualization photographs. For the analytical work the same ventral system configuration was modeled with two computational grids to evaluate the effect of grid density. Both grids gave good results. The finer-grid solution produced more detailed flow patterns and predicted performance parameters, such as thrust and discharge coefficient, within 1 percent of the measured values. PARC3D flow visualization images are shown for comparison with the paint streak photographs. Modeling and computational issues encountered in the analytical work are discussed.

  15. Captive breeding, reintroduction, and the conservation genetics of black and white ruffed lemurs, Varecia variegata variegata.

    PubMed

    Wyner, Y M; Amato, G; Desalle, R

    1999-12-01

    A character-based phylogenetic species concept approach was used to examine conservation unit status for three wild populations of black and white ruffed lemurs, Varecia vareigata variegata, from Betampona (N = 3), Manombo (N = 6), and Ranomafana (N = 14), Madagascar. Population aggregation analysis was performed on 548 bp from the control region (D-loop) of the mitochondrial DNA (mtDNA). Twenty-one diagnostic sites were found to differentiate the Betampona (northern) population from the Manombo/Ranomafana (southern) populations. Additionally, individuals from the North American captive population (N = 11) and from Parc Ivoloina, Madagascar (N = 6) were examined for the same mtDNA fragment. The captive animals more closely resembled the southern populations and the Parc Ivoloina animals were more similar to the northern population. However, the inclusion of these ex situ animals reduced the number of diagnostic sites differentiating the northern and southern populations. Our genetic data were used to assess the ongoing management strategy for reintroducing individuals into the Betampona population and for introducing new founders into the ex situ population. This study demonstrates the utility of combining genetic information with a consideration of conservation priorities in evaluating the implementation of management strategies.

  16. [Presidential address at the 20th Journees sur la Fertilite et l'Orthogenie].

    PubMed

    Dourlen-rollier, A M

    1993-01-01

    Recollections of the author's early experiences in French family planning and reflections on the ethical issues and legal status of new fertility technologies are the major topics of this address. The group that was to become le Mouvement francais pour le Planning Familial (MFPF) was founded in 1956 by the author and others and opened its first family planning center in 1961, before contraception became legal. Despite opposition from physicians and Catholic clergy, the MFPF operated 100 centers serving over 100,000 clients by 1965. In 1969 the MFPF began a study of abortion. Despite legalization, the controversy concerning the legitimacy of abortion has not subsided. More recently, the practices of artificial insemination with donor sperm, in vitro fertilization, surrogate mothers, and other medically assisted fertility technologies have raised moral, ethical, and legal questions for all societies. The questions range from the legitimacy of gamete donation to the status of unused embryos. The dissociation of different stages of the reproductive process affects concepts of filiation, paternity and maternity. In the absence of appropriate legislation, it has been left largely to the courts to create a new body of law at this frontier. The review of legislation in France, elsewhere in Europe, and in the U.S. concerning contested filiation in cases of artificial insemination, the legitimacy of insemination of a woman after the death of her spouse, the preservation and donation of embryos, surrogate motherhood, the child's rights to information about his biological parents, and other questions indicate that no consensus has yet emerged concerning the admissibility and legitimacy of specific practices. It would be highly desirable for the European countries to adopt a common legislation in these areas.

  17. The 1994 EUROMET collection of micrometeorites at Cap-Prudhomme, Antarctica

    NASA Astrophysics Data System (ADS)

    Maurette, M.; Immel, G.; Engrand, C.; Kurat, G.; Pillinger, C. T.

    1994-07-01

    Advance funding from IFRTP (Institut Francais pour la Recherche et pour la Technique Polaire) for micrometeorite collection at Cap-Prudhomme has allowed construction of a new micrometeorite 'factory,' conceived to greatly reduce contamination of the ultraclean ice by our activities. The potential problems include fly ash, rust grains, fuel spills 'sticking to the shoes,' and trace elements from the plasticizers used in plastic tubing. In the new factory, intended to produce and then cycle 10-15 tons of melt ice water per day, all parts exposed to water were replaced by either stainless steel or teflon. After examination with a microscope and their transfer into teflon and or glass vials, all samples were frozen the day of their collection. The factory operated from December 15, 1993, through February 6, 1994. Problems included injuries as well as very bad weather conditions, characterized by both the heaviest snow falls observed and unexpected gusts from a blizzard. Also, several new components of the factory did not function properly under the extreme conditions of Antarctica. Our major objective was to obtain the 'cleanest' and 'purest' 25-50 microns micrometeorites ever collected in Antarctica, for comparison with stratospheric Interplanetary Dust Particles (IDPs). We could not fulfill this premise, but we recovered the best 100-400-micron-size fraction of 'giant' micrometeorites ever collected on Earth. Our 26 daily collections are listed,refering to an 'index of quality.' Aliquots of these daily collections will be distributed to major institutions in Austria, England, the U.S.A., and Japan, to be preserved for future generations. The Antarctica ice sheet is truly a gigantic, ultraclean, and inexhaustible micrometeorite collector, but it is very tricky to recover 'ultraclean' micrometeorites from it.

  18. Agriculture: A source of raw materials for industrial purposes the French strategy

    SciTech Connect

    Mauguin, P.; Gaouyer, J.P.; Labrousse, S.

    1995-11-01

    Creating new value-added products from agricultural and forestry biomass can present opportunities for diversifying industry, preserving agricultural activities and reinvigorating exploitation of forests. Stimulating new markets for agriculture and forestry products is strategically important for France, in order to cushion the effects of the reform of the European Common Policy (CAP), while maintaining the commitments assessed at the Rio Coference. The promotion of new markets should constitute a major vector for rural development, by marking use of agricultural lands no longer needed for food crops due to the glut of foodstuffs on the market. In the next few years, energy uses of biomass should help hold down greenhouse gas emissions, by regulating and storing CO{sub 2}. For each of these markets, whether for energy uses (solid, liquid or gaseous fuels) or for other applications, the first priority is to match prices and specifications of the fossil fuels that are to be deplaced, with minimum impact on the environment. To match these goals, the French government has launched a new research group, Agriculture for Chemicals and Energy (AGRICE). AGRICE has been set up for a renewable five years period. Its members are: Agriculture, Industry, Research and Environment departments; the Institut National de la Recherche Agronomique (INRA), the Institut Francais due Petrole (IFP), the French Agency for Environment and Energy (Ademe); Wheat producers, Beet growers, and oil seed producers; and Rhone Poulenc (chemicals), TOTAL (oil company). In 1995, AGRICE will have a 40 Millions FFrancs from public funds, supplemented by 25 Millions FFrancs from business and trade groups.

  19. Characterization of Saharan dust properties transported towards Europe in the frame of the FENNEC project: a case study

    NASA Astrophysics Data System (ADS)

    Marnas, F.; Chazette, P.; Flamant, C.; Royer, P.; Sodemman, H.; Derimian, Y.

    2012-04-01

    In the framework of the FENNEC experiment (6 to 30 June 2011) an effort has been dedicated to characterize Saharan dust plumes transported towards southern Europe. Hence, a multi instrumented field campaign has been conducted. Ground based nitrogen Raman LIDAR (GBNRL) has been deployed in southern Spain close to Marbella, simultaneously with airborne lidar (AL) performing measurements over both the tropical Atlantic Ocean and the western Africa (from 2 to 23 June). The GBNRL was equipped with co-polar and cross-polar channels to perform continuous measurements of the dust aerosols trapped in the troposphere. It was developed by LSCE with the support of the LEOSPHERE Company. The French FALCON 20 research aircraft operated by SAFIRE (Service des Avions Francais Instrumentés pour la Recherche en Environnement) carried the AL Leandre Nouvelle Generation (LNG) as well as a dropsonde releasing system and radiometers. A major, one week long, dust event has been sampled over Spain from 25 June to 1 July with high optical depth (>0.5 at 355nm) and particular depolarization ratios (15 to 25%). Backtrajectory studies suggest that the dust particles observed were from dust uplifts that occurred in Southern Morocco and Northern Mauritania. The event has been also documented 3 days before by the AL flying over Mauritania. AERONET sunphotometer measurements of aerosol properties, along the dust plume transport path appear to be coherent with both the lidar and the backtrajectory analysis. These analysis exhibit a likely major contribution from the Western Sahara sources to the Southern Europe. Such a contribution may impact the visibility and then the airtrafic, modify the tropospheric chemistry, and add nutrients to both the Mediterranean Sea and the continental surfaces. It can also affect the health of European populations. We will present strategy of the experiment and the case study built from measurements performed at the end of June.

  20. Heterogeneities and geometry of sedimentary bodies in a fluvio-deltaic reservoir

    SciTech Connect

    Ravenne, C.; Eschard, R.; Mathieu, Y.; Montadert, L.; Rudkiewicz, J.L.; Galli, A.

    1989-06-01

    This paper gives the initial results of a two- and three-dimensional (2D and 3D) geological study that aimed at describing reservoir heterogeneities. This study serves as a basis for the conditional simulation of the geometry of a fluvio-deltaic reservoir presented in a companion paper. These two studies should solve the difficult problems of interpolating between wells and thereby the problem of forecasting the extension of sedimentary bodies. The research is being carried out by Inst. Francais du Petrole and Center of Geostatistics, Paris School of Mines. The study was made in the middle Jurassic in Yorkshore, which is very similar to the Brent formation in the North Sea. In the 2D phase, an outcrop consisting of a 1-km (0.6-mile) -long and approximately 30-m (100-ft) -high cliff was described with a photogeological interpretation. The sedimentological representation was carried out by means of several vertical cross sections. In the 3D phase, 36 boreholes were continuously cored and logged behind the cliff over an area of 1 km/sup 2/ (0.4 sq miles). The boreholes were about 300 m (985 ft) apart except in one grid where the distance was progressively reduced to 20 m (66 ft). This phase was designed to follow the evolution of the sedimentary bodies and their physical properties and to compare the correlation that could have been made (1) with fewer boreholes and (2) without the existence of the cliff. These studies provide new tools for understanding and describing the shape and heterogeneities of a reservoir.

  1. Basin evaluation in deltaic series using 2-D numerical modeling a comparison of Mahakam delta and south Louisiana/Gulf of Mexico case histories

    SciTech Connect

    Burrus, J. ); De Choppin, J.G.; Grosjean, J.L.; Oudin, J.L. ); Schwarzer, T. ); Schroeder, F.; Lander, R. )

    1993-09-01

    Integrated numerical modeling of petroleum, generation and migration is difficult to apply in deltaic series. Using Institut Francais du Petrole's two-dimensional model TEMISPACK, we tried to simulate the petroleum history along a 70 km long east-west regional section in the Mahakam delta (Indonesia) and a 800 km long north-south section in south Louisiana/Gulf of Mexico. The two basins contain thick (>10 km) accumulations of the post middle miocene. The principal results are as follows (1) Both basins have similar overpressure profiles caused by thick shales with nano-darcy permeabilities. Compaction, not oil or gas generation, controls the overpressure histories. (2) In both basins, the thermal history is dominated by burial rate, thermal blanketing, and undercompaction. Basinward increases in thermal gradients are probably due to basinward increases in shale content and undercompaction, rather than geodynamic processes. (3) We used an upscaling procedure to define sedimentary facies and properties for each cell in the models. In both cases, we found a huge permeability anisotropy of interbedded facies was necessary to match observed pressure profiles and hydrocarbon distributions. This anisotropy results in a dominant [open quotes]parallel-to-bedding[close quotes] migration pattern, with only a moderate (<0.5 km) vertical migration component. (4) A fundamental difference between the Mahakam and the Gulf coast petroleum systems is the hole of growth faults. In the Gulf Coast, huge growth faults connect deep overpressured, overmature Tertiary source facies with shallow, interbedded sandy reservoirs. Enhanced vertical permeability in the vicinity of these fault zones allows for several kilometers of vertical migration. In the Mahakam delta, where growth faults are less prevalent, deep overpressured shales have very poor expulsion efficiency; gas and oil in shallow reservoirs are shown to be fed mostly by coals located above, and not within, the overpressured zone.

  2. Application of IAPAC fuel injection for low emissions small two-stroke engines

    SciTech Connect

    Duret, P.; Dabadie, J.C.; Colliou, T.

    1995-12-31

    The implementation of the Institut Francais du Petrole developed Compressed Air Assisted Fuel Injection Process (named IAPAC) in a two-stroke engine allows the introduction of the fuel separately from the scavenging air, which in consequence minimizes fuel short-circuiting. The inherent mechanical principle of the IAPAC process which uses the crankcase compressed air to finely atomize the fuel, provides the advantages of direct injection but in addition uses conventional low pressure automotive type injection technology with commercially available gasoline injectors. In earlier work the authors showed an example of the application of this fuel injection technology to a PIAGGIO single cylinder 125 cc scooter two-stroke engine. In this paper, an update of the results obtained with this new engine is presented and confirms the ultra-low emissions capability for two-wheeler application. This technology is also used with other IAPAC 2-stroke engines of various size and displacement to demonstrate how the application of IAPAC to marine outboard 2-stroke engines, is a good answer face to the new environmental regulations. The EPA 2006 regulation can easily be met over the whole outboard engine power range with associated significant fuel economy benefits. The Bodensee stage 1 regulation can be met without catalyst, while the addition of a catalyst (at least for the medium to the high engine power range) will be necessary to meet the Bodensee stage 2 regulation. It has already been reported in the previous work how careful attention has been paid to ensure that the IAPAC sn,stem remains mechanically simple and keep the additional cost as low as possible. Finally, a brief cost impact analysis of a conversion of conventional 2-stroke engine to IAPAC is here presented. The ways of possible further cost reduction are also discussed.

  3. Late abortion meeting, Paris / France.

    PubMed

    Spinelli, A

    1989-01-01

    On January 27 and 28, 1989 a workshop and a meeting were organized in Paris by Mouvement Francais pour le Planning Familial (MFPF/France) and the IPPF Europe Region. The workshop was held on the first day. 24 staff and volunteers from Planned Parenthood Associations of 15 countries attended, reviewing abortion laws, the definition of therapeutic abortion, and the incidence and problems of second trimester abortion. Second trimester abortion is available in only a few European countries. Second trimester abortions are rare in France (about 2000 per annum), and in 1986 1717 French women travelled to England in order to seek an abortion. All late abortions are performed for serious reasons. Older women may mistake signs of pregnancy for the onset of the menopause; and women fearful of social or familial punishment, especially teenagers, may be reluctant to consult a doctor. The experiences of Denmark and Sweden, where the problem is partially solved, suggest some strategies: optimize accessibility of contraceptive services, particularly for women at higher risk of late abortion; diminish the taboo surrounding abortion, so that women are less frightened to seek help at an early stage of pregnancy; make abortion services available in all regions of the country; avert time-consuming enforced waiting periods or consent for minors; and stimulate public information campaigns on the importance of seeking help early. On January 28 a meeting involving about 200 participants took place at the Universite Paris Dauphine, Salle Raymond Aron. Speakers at the meeting discussed the issue of late abortion in Europe, the difficulties of obtaining late abortions, counseling, medical problems, the woman's point of view, and possible solutions. At the close of the meeting, the MFPF called on the French government to modify some of the articles in the Penal Code that restrict women's access to safe and legal abortion.

  4. Emergence and spread of O16-ST131 and O25b-ST131 clones among faecal CTX-M-producing Escherichia coli in healthy individuals in Hunan Province, China

    PubMed Central

    Zhong, Yi-Ming; Liu, Wen-En; Liang, Xiang-Hui; Li, Yan-Ming; Jian, Zi-Juan; Hawkey, Peter M.

    2015-01-01

    Objectives The objectives of this study were to determine CTX-M-producing Escherichia coli ST131 strain prevalence in stool specimens from healthy subjects in central China and to molecularly characterize clonal groups. Methods From November 2013 to January 2014, stool specimens from healthy individuals in Hunan Province were screened for ESBL-producing E. coli using chromogenic medium and CTX-M genotypes and phylogenetic groups were determined. ST131 clonal groups were detected by PCR and characterized for antibiotic resistance, fimH, gyrA and parC alleles, plasmid-mediated quinolone resistance determinants, virulence genotypes and PFGE patterns. Results Among 563 subjects, 287 (51.0%) exhibited the presence of faecal ESBL-producing E. coli, all of which produced CTX-M enzymes. The most common CTX-M genotypes were CTX-M-14 (48.4%), CTX-M-15 (27.5%) and CTX-M-27 (15.0%). Of the 287 CTX-M-producing isolates, 32 (11.1%) belonged to the ST131 clone. O16-ST131 isolates were dominant (75%) and contained the fimH41 allele. The remaining eight (25%) ST131 isolates were of the O25b subgroup and contained fimH30 or fimH41. Ciprofloxacin resistance was found in 100% of the O25b-ST131 isolates, whereas only 8% of the O16-ST131 isolates were resistant. All of the O25b-ST131 isolates except one showed gyrA1AB and parC1aAB mutations; most of the O16-ST131 isolates had gyrA1A and parC1b mutations. The virulence genotypes of O16-ST131 resembled those of the O25b-ST131 isolates. The 32 ST131 isolates formed one large group at the 64% similarity level. They comprised 15 PFGE groups (defined at ≥85% similarity). Conclusions O16-ST131 isolates have emerged as the predominant type of ST131 isolate in faecal CTX-M-producing E. coli in healthy individuals in China. PMID:25957581

  5. Fitness of Streptococcus pneumoniae Fluoroquinolone-Resistant Strains with Topoisomerase IV Recombinant Genes▿

    PubMed Central

    Balsalobre, Luz; de la Campa, Adela G.

    2008-01-01

    The low prevalence of ciprofloxacin-resistant (Cpr) Streptococcus pneumoniae isolates carrying recombinant topoisomerase IV genes could be attributed to a fitness cost imposed by the horizontal transfer, which often implies the acquisition of larger-than-normal parE-parC intergenic regions. A study of the transcription of these genes and of the fitness cost for 24 isogenic Cpr strains was performed. Six first-level transformants were obtained either with PCR products containing the parC quinolone resistance-determining regions (QRDRs) of S. pneumoniae Cpr mutants with point mutations or with a PCR product that includes parE-QRDR-ant-parC-QRDR from a Cpr Streptococcus mitis isolate. The latter yielded two strains, T6 and T11, carrying parC-QRDR and parE-QRDR-ant-parC-QRDR, respectively. These first-level transformants were used as recipients in further transformations with the gyrA-QRDR PCR products to obtain 18 second-level transformants. In addition, strain Tr7 (which contains the GyrA E85K change) was used. Reverse transcription-PCR experiments showed that parE and parC were cotranscribed in R6, T6, and T11; and a single promoter located upstream of parE was identified in R6 by primer extension. The fitness of the transformants was estimated by pairwise competition with R6 in both one-cycle and two-cycle experiments. In the one-cycle experiments, most strains carrying the GyrA E85K change showed a fitness cost; the exception was recombinant T14. In the two-cycle experiments, a fitness cost was observed in most first-level transformants carrying the ParC changes S79F, S79Y, and D83Y and the GyrA E85K change; the exceptions were recombinants T6 and T11. The results suggest that there is no impediment due to a fitness cost for the spread of recombinant Cpr S. pneumoniae isolates, since some recombinants (T6, T11, and T14) exhibited an ability to compensate for the cost. PMID:18160515

  6. The Emergence of Quinolone Resistant Shigella sonnei, Pondicherry, India.

    PubMed

    Das, Ankita; Natarajan, Mailan; Mandal, Jharna

    2016-01-01

    Ciprofloxacin resistant Shigella sonnei across the globe have been increasing alarmingly. In order to understand the emergence of S.sonnei with respect to ciprofloxacin resistance in our patient population, the following study was carried out. Of the 184 Shigella sp. Isolated from 2012 to 2015, 34 S.sonnei which were confirmed by standard methods and subjected to antimicrobial susceptibility testing were selected. The minimum inhibitory concentrations (MICs) of 16/34 quinolone resistant isolates tested ranged from 4micrograms/ml to 16micrograms/ml for ciprofloxacin, from 16 micrograms/ml to 64 micrograms/ml for ofloxacin and from 16micrograms/ml to 64micrograms/ml for levofloxacin. Sequence determination of the quinolone resistance determining regions of gyrA, gyrB, parC, and parE genes showed mutations in GyrA at Gln69/Trp, Phe71/Ser, Ser72/Pro, Met75/Leu, Ser90/Cys, Met94/Leu, His106/Pro, Asn161/His, Thr163/Ala and in ParC at Ala64/Asp. Among the plasmid-mediated quinolone resistance (PMQRs) targets investigated,qnrB was the most (93.7%) prevalent followed by qnrC (18.7%). None hadqnrA, qnrS and qepA. Two (0.1%) of the isolates harboured theaac(6')-lb gene. Drug accumulation assay detected the presence of efflux pump activity in 9/15 (60%) among ciprofloxacin resistant isolates. All isolates harboured the ipaH gene followed by ial (17.6%), sen (11.7%), set1A&set1B (5.8%) genes. None had stx1 element. PCR for Enterobacterial repetitive intergenic consensus (ERIC) sequences resulted in 4 unique clusters, of which Type III was the most (44%) dominant but there was no correlation between the ERIC types and the antibiotic resistance pattern or the virulence profile. A documented increase in S.sonnei harbouring the qnrgenes and some unusual genes like set1Aand indicate an ongoing process of horizontal gene transfer. The accumulation of novel mutations in GyrA and ParC in the presence of efflux pump and PMQR genes contributed to the raised MIC to quinolones. These

  7. The Emergence of Quinolone Resistant Shigella sonnei, Pondicherry, India

    PubMed Central

    2016-01-01

    Ciprofloxacin resistant Shigella sonnei across the globe have been increasing alarmingly. In order to understand the emergence of S.sonnei with respect to ciprofloxacin resistance in our patient population, the following study was carried out. Of the 184 Shigella sp. Isolated from 2012 to 2015, 34 S.sonnei which were confirmed by standard methods and subjected to antimicrobial susceptibility testing were selected. The minimum inhibitory concentrations (MICs) of 16/34 quinolone resistant isolates tested ranged from 4micrograms/ml to 16micrograms/ml for ciprofloxacin, from 16 micrograms/ml to 64 micrograms/ml for ofloxacin and from 16micrograms/ml to 64micrograms/ml for levofloxacin. Sequence determination of the quinolone resistance determining regions of gyrA, gyrB, parC, and parE genes showed mutations in GyrA at Gln69/Trp, Phe71/Ser, Ser72/Pro, Met75/Leu, Ser90/Cys, Met94/Leu, His106/Pro, Asn161/His, Thr163/Ala and in ParC at Ala64/Asp. Among the plasmid-mediated quinolone resistance (PMQRs) targets investigated,qnrB was the most (93.7%) prevalent followed by qnrC (18.7%). None hadqnrA, qnrS and qepA. Two (0.1%) of the isolates harboured theaac(6’)-lb gene. Drug accumulation assay detected the presence of efflux pump activity in 9/15 (60%) among ciprofloxacin resistant isolates. All isolates harboured the ipaH gene followed by ial (17.6%), sen (11.7%), set1A&set1B (5.8%) genes. None had stx1 element. PCR for Enterobacterial repetitive intergenic consensus (ERIC) sequences resulted in 4 unique clusters, of which Type III was the most (44%) dominant but there was no correlation between the ERIC types and the antibiotic resistance pattern or the virulence profile. A documented increase in S.sonnei harbouring the qnrgenes and some unusual genes like set1Aand indicate an ongoing process of horizontal gene transfer. The accumulation of novel mutations in GyrA and ParC in the presence of efflux pump and PMQR genes contributed to the raised MIC to quinolones. These

  8. Clonal Spread of Levofloxacin-Resistant Streptococcus pneumoniae Invasive Isolates in Madrid, Spain, 2007 to 2009▿

    PubMed Central

    Rodríguez-Avial, Iciar; Ramos, Belén; Ríos, Esther; Cercenado, Emilia; Ordobás, María; Sanz, Juan Carlos

    2011-01-01

    Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n = 32 isolates), 19A (n = 4 isolates), 7F (n = 3 isolates), 9V (n = 2 isolates), 10A (n = 1 isolate), 19F (n = 1 isolate), 6B (n = 1 isolate), and nontypeable (n = 1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden15A-25 clone. Levofloxacin resistance was also detected among multiresistant (ST27619A, Spain9V-ST156, ST8819F, and ST15426B) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST120119A, and ST263910A) clones. PMID:21383091

  9. Full Navier-Stokes analysis of a two-dimensional mixer/ejector nozzle for noise suppression

    NASA Technical Reports Server (NTRS)

    Debonis, James R.

    1992-01-01

    A three-dimensional full Navier-Stokes (FNS) analysis was performed on a mixer/ejector nozzle designed to reduce the jet noise created at takeoff by a future supersonic transport. The PARC3D computational fluid dynamics (CFD) code was used to study the flow field of the nozzle. The grid that was used in the analysis consisted of approximately 900,000 node points contained in eight grid blocks. Two nozzle configurations were studied: a constant area mixing section and a diverging mixing section. Data are presented for predictions of pressure, velocity, and total temperature distributions and for evaluations of internal performance and mixing effectiveness. The analysis provided good insight into the behavior of the flow.

  10. Hadronic molecules with a D ¯ meson in a medium

    NASA Astrophysics Data System (ADS)

    Caramés, T. F.; Fontoura, C. E.; Krein, G.; Tsushima, K.; Vijande, J.; Valcarce, A.

    2016-08-01

    We study the effect of a hot and dense medium on the binding energy of hadronic molecules with open-charm mesons. We focus on a recent chiral quark-model-based prediction of a molecular state in the N D ¯ system. We analyze how the two-body thresholds and the hadron-hadron interactions are modified when quark and meson masses and quark-meson couplings change in a function of the temperature and baryon density according to predictions of the Nambu-Jona-Lasinio model. We find that in some cases the molecular binding is enhanced in medium as compared to their free-space binding. We discuss the consequences of our findings for the search for exotic hadrons in high-energy heavy-ion collisions as well as in the forthcoming facilities FAIR or J-PARC.

  11. Molecular characterization of fluoroquinolone-resistant Aeromonas spp. isolated from imported shrimp.

    PubMed

    Shakir, Zakiya; Khan, Saeed; Sung, Kidon; Khare, Sangeeta; Khan, Ashraf; Steele, Roger; Nawaz, Mohamed

    2012-11-01

    Sixty-three nalidixic acid-resistant Aeromonas sp. isolates were obtained from imported shrimp. Phylogenetic analysis of gyrB sequences indicated that 18 were A. enteropelogenes, 26 were A. caviae, and 19 were A. sobria. Double missense mutations in the quinolone resistance-determining region (QRDR) of gyrA at codon 83 (Ser→Val/Ile) and codon 92 (Leu→Met) coupled with a point mutation of parC at codon 80 (Ser→Ile/Phe) conferred high levels of quinolone resistance in the isolates. A majority of A. enteropelogenes and A. caviae strains harbored toxin genes, whereas only a few A. sobria strains harbored these genes. The fluoroquinolone-resistant Aeromonas spp. exhibited higher cytotoxicity than fluoroquinolone-sensitive, virulent Aeromonas spp. to rat epithelial cells.

  12. Plasmid-mediated QnrS2 determinant in an Aeromonas caviae isolate recovered from a patient with diarrhoea.

    PubMed

    Arias, A; Seral, C; Navarro, F; Miró, E; Coll, P; Castillo, F J

    2010-07-01

    A qnrS2 gene was identified in an Aeromonas caviae isolate (MICs of ciprofloxacin, norfloxacin and ofloxacin >32 mg/L) from a stool sample collected from a patient with gastroenteritis. The analysis of the gyrA and parC genes revealed amino acid substitutions Ser83-Ile and Ser80-Thr, respectively. In addition, five out of 41 nalidixic acid-resistant Aeromonas isolates studied (26 identified as Aeromonas veronii bv sobria and 15 identified as A. caviae) showed ciprofloxacin resistance. The identification of plasmid-mediated qnr genes outside of the Enterobacteriaceae underlines a possible diffusion of these resistance determinants among Gram-negative rods. This emphasizes the importance of monitoring the emergence of these determinants as well as their dissemination among the Aeromonadaceae.

  13. Identification of Salmonella enterica Serovar Typhi Genotypes by Use of Rapid Multiplex Ligation-Dependent Probe Amplification

    PubMed Central

    Pham Thanh, Duy; Tran Vu Thieu, Nga; Tran Thuy, Chau; Lodén, Martin; Tuin, Kiki; Campbell, James I.; Van Minh Hoang, Nguyen; Voong Vinh, Phat; Farrar, Jeremy J.; Holt, Kathryn E.; Dougan, Gordon

    2013-01-01

    Salmonella enterica serovar Typhi, the causative agent of typhoid fever, is highly clonal and genetically conserved, making isolate subtyping difficult. We describe a standardized multiplex ligation-dependent probe amplification (MLPA) genotyping scheme targeting 11 key phylogenetic markers of the S. Typhi genome. The MLPA method demonstrated 90% concordance with single nucleotide polymorphism (SNP) typing, the gold standard for S. Typhi genotyping, and had the ability to identify isolates of the H58 haplotype, which is associated with resistance to multiple antimicrobials. Additionally, the assay permitted the detection of fluoroquinolone resistance-associated mutations in the DNA gyrase-encoding gene gyrA and the topoisomerase gene parC with a sensitivity of 100%. The MLPA methodology is simple and reliable, providing phylogenetically and phenotypically relevant genotyping information. This MLPA scheme offers a more-sensitive and interpretable alternative to the nonphylogenetic subgrouping methodologies that are currently used in reference and research laboratories in areas where typhoid is endemic. PMID:23824765

  14. Study of neutrino interactions at the T2K near detector

    NASA Astrophysics Data System (ADS)

    Hillairet, A.; T2K Collaboration

    2013-10-01

    The Tokai-To-Kamioka (T2K) experiment was designed to measure the oscillation of muon neutrinos produced at the J-PARC accelerator in Japan. The Super-Kamiokande detector acts as the far detector and a near detector is installed in the path of the neutrino beam to reduce uncertainties on the flux and cross sections. This near detector, called ND280, is located 280 m from the production target of the T2K neutrino beamline in order to measure the characteristics of the beam prior to any oscillation. The first ND280 analysis of the momentum-angle distribution of the muon produced by muon neutrino charged current interactions has been performed. These results have also been used to determine a flux-averaged cross section.

  15. Fluoroquinolone-resistant Streptococcus agalactiae isolates from Argentina.

    PubMed

    Faccone, D; Guerriero, L; Méndez, E; Errecalde, L; Cano, H; Yoyas, N; Togneri, A; Romanowski, V; Galas, M; Whonet, Red; Corso, A

    2010-01-01

    Fluoroquinolone resistance is a growing problem that has only recently emerged in S. agalactiae. Between 2005-2007, WHONET--Argentina network evaluated levofloxacin susceptibility in 1128 clinical S. agalactiae isolates, 10 (0.9%) of which proved to be resistant. Nine of them had come from 5 hospitals (in Buenos Aires City and 4 Argentinean provinces) and recovered from urine (n=7) and vaginal screening cultures (n=2). Three strains were also resistant to macrolides, lincosamides and B streptogramins due to the ermA gene. All nine fluoroquinolone-resistant isolates bore the same two mutations, Ser79Phe in ParC and Ser81Leu in GyrA proteins. Genetic relationships were analyzed by Apal-PFGE and two clones were determined, A (n=6) and B (n=3). To our knowledge, these are the first fluoroquinolone-resistant S. agalactiae isolates detected in Latin America.

  16. Molecular characterization of a clinical Haemophilus parainfluenzae isolate with cefotaxime resistance and decreased susceptibility to fluoroquinolones.

    PubMed

    Faccone, Diego; Lopez-Ruitti, Paula; Vazquez, Miryam; Guerriero, Leonor; Lucero, Celeste; Gagetti, Paula; Ceriana, Paola; Corso, Alejandra

    2016-10-01

    We report an H. parainfluenzae clinical isolate resistant to cefotaxime and with decreased susceptibility to ciprofloxacin recovered from a patient with cystic fibrosis. The isolate had elevated MICs of ampicillin (256mg/L), amoxicillin-clavulanate (8mg/L), cefuroxime (8mg/L) and cefotaxime (4mg/L), and showed a β-lactamase-producing amoxicillin-clavulanic acid-resistant (BLPACR) phenotype. A blaTEM-1 plus five amino acid substitutions in the PBP3 were found: Ser385Thr, Val511Ala, Ile519Val, Asn526Lys and Asp551Leu. MIC of ciprofloxacin was 0.5mg/L, and substitutions in gyrA (Ser84Tyr) and parC (Ser84Phe) genes were detected.

  17. Computational analysis of ramjet engine inlet interaction

    NASA Technical Reports Server (NTRS)

    Duncan, Beverly; Thomas, Scott

    1992-01-01

    A computational analysis of a ramjet engine at Mach 3.5 has been conducted and compared to results obtained experimentally. This study focuses on the behavior of the inlet both with and without combustor backpressure. Increased backpressure results in separation of the body side boundary layer and a resultant static pressure rise in the inlet throat region. The computational results compare well with the experimental data for static pressure distribution through the engine, inlet throat flow profiles, and mass capture. The computational analysis slightly underpredicts the thickness of the engine body surface boundary layer and the extent of the interaction caused by backpressure; however, the interaction is observed at approximately the same level of backpressure both experimentally and computationally. This study demonstrates the ability of two different Navier-Stokes codes, namely RPLUS and PARC, to calculate the flow features of this ramjet engine and to provide more detailed information on the process of inlet interaction and unstart.

  18. Spectrum Orbit Utilization Program Documentation: SOUP5 Version 3.8 User's Manual, Volume 2, Appendices a Through G

    NASA Technical Reports Server (NTRS)

    Davidson, J.; Ottey, H. R.; Sawitz, P.; Zusman, F. S.

    1985-01-01

    The appendixes of the user manual are presented. Input forms which may be used to prepare data for the SOUP5V3.4 of the R2BCSAT-83 data base are given. The IBM job control language which can be used to run the SOUP5 system from a magnetic tape is described. Copies of a run using the delivered tape and IBM OS/MVS Job Control Language card deck are illustrated. Numerical limits on scenario data requests are listed. Error handling, error messages and editing procedures are also listed. Instructions as to how to enter a protection ratio template are given. And relation between PARC prameter, channelization, channel families, and interference categories are also listed.

  19. Search for the deeply bound K-pp state from the semi-inclusive forward-neutron spectrum in the in-flight K- reaction on helium-3

    NASA Astrophysics Data System (ADS)

    Hashimoto, T.; Ajimura, S.; Beer, G.; Bhang, H.; Bragadireanu, M.; Busso, L.; Cargnelli, M.; Choi, S.; Curceanu, C.; Enomoto, S.; Faso, D.; Fujioka, H.; Fujiwara, Y.; Fukuda, T.; Guaraldo, C.; Hayano, R. S.; Hiraiwa, T.; Iio, M.; Iliescu, M.; Inoue, K.; Ishiguro, Y.; Ishikawa, T.; Ishimoto, S.; Itahashi, K.; Iwai, M.; Iwasaki, M.; Kato, Y.; Kawasaki, S.; Kienle, P.; Kou, H.; Ma, Y.; Marton, J.; Matsuda, Y.; Mizoi, Y.; Morra, O.; Nagae, T.; Noumi, H.; Ohnishi, H.; Okada, S.; Outa, H.; Piscicchia, K.; Poli Lener, M.; Romero Vidal, A.; Sada, Y.; Sakaguchi, A.; Sakuma, F.; Sato, M.; Scordo, A.; Sekimoto, M.; Shi, H.; Sirghi, D.; Sirghi, F.; Suzuki, S.; Suzuki, T.; Tanida, K.; Tatsuno, H.; Tokuda, M.; Tomono, D.; Toyoda, A.; Tsukada, K.; Vazquez Doce, O.; Widmann, E.; Yamaga, T.; Yamazaki, T.; Yim, H.; Zhang, Q.; Zmeskal, J.

    2015-06-01

    An experiment to search for the K-pp bound state was performed via the in-flight {}^3He(K-,n) reaction using 5.3 × 10^9 kaons at 1 GeV/c at the J-PARC hadron experimental facility. In the semi-inclusive neutron missing-mass spectrum at θ n^{lab}=0°, no significant peak was observed in the region corresponding to K-pp binding energy larger than 80 MeV, where a bump structure has been reported in the Λ p final state in different reactions. Assuming the state to be isotropically decaying into Λ p, mass-dependent upper limits on the production cross section were determined to be 30-180, 70-250, and 100-270μb/sr, for the natural widths of 20, 60, and 100 MeV, respectively, at 95% confidence level.

  20. The ion beam sputtering facility at KURRI: Coatings for advanced neutron optical devices

    NASA Astrophysics Data System (ADS)

    Hino, Masahiro; Oda, Tatsuro; Kitaguchi, Masaaki; Yamada, Norifumi L.; Tasaki, Seiji; Kawabata, Yuji

    2015-10-01

    We describe a film coating facility for the development of multilayer mirrors for use in neutron optical devices that handle slow neutron beams. Recently, we succeeded in fabricating a large neutron supermirror with high reflectivity using an ion beam sputtering system (KUR-IBS), as well as all neutron supermirrors in two neutron guide tubes at BL06 at J-PARC/MLF. We also realized a large flexible self-standing m=5 NiC/Ti supermirror and very small d-spacing (d=1.65 nm) multilayer sheets. In this paper, we present an overview of the performance and utility of non-magnetic neutron multilayer mirrors fabricated with the KUR-IBS

  1. Identification of Raoultella terrigena as a Rare Causative Agent of Subungual Abscess Based on 16S rRNA and Housekeeping Gene Sequencing

    PubMed Central

    Wang, Yu; Jiang, Xiawei; Xu, Zemin; Ying, Chaoqun; Yu, Wei; Xiao, Yonghong

    2016-01-01

    A 63-year-old-man was admitted to our hospital with severe subungual abscess. Bacteria were isolated from pus samples, and an inconsistent identification was shown by VITEK 2 system and MALDI-TOF mass spectrometry as Raoultella planticola and Raoultella terrigena, respectively. Molecular identification by 16S rRNA sequencing suggested that the isolate is R. terrigena, and this was further demonstrated by sequencing three housekeeping genes (rpoB, gyrA, and parC) with phylogenetic analysis. To our knowledge, this is the first report of subungual abscess caused by R. terrigena, a rare case of human infection due to soil bacterium. Our study highlights the technique importance on this pathogen identification. PMID:27379169

  2. Identification of Raoultella terrigena as a Rare Causative Agent of Subungual Abscess Based on 16S rRNA and Housekeeping Gene Sequencing.

    PubMed

    Wang, Yu; Jiang, Xiawei; Xu, Zemin; Ying, Chaoqun; Yu, Wei; Xiao, Yonghong

    2016-01-01

    A 63-year-old-man was admitted to our hospital with severe subungual abscess. Bacteria were isolated from pus samples, and an inconsistent identification was shown by VITEK 2 system and MALDI-TOF mass spectrometry as Raoultella planticola and Raoultella terrigena, respectively. Molecular identification by 16S rRNA sequencing suggested that the isolate is R. terrigena, and this was further demonstrated by sequencing three housekeeping genes (rpoB, gyrA, and parC) with phylogenetic analysis. To our knowledge, this is the first report of subungual abscess caused by R. terrigena, a rare case of human infection due to soil bacterium. Our study highlights the technique importance on this pathogen identification.

  3. A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam

    PubMed Central

    Terada, K.; Ninomiya, K.; Osawa, T.; Tachibana, S.; Miyake, Y.; Kubo, M. K.; Kawamura, N.; Higemoto, W.; Tsuchiyama, A.; Ebihara, M.; Uesugi, M.

    2014-01-01

    The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (106 s−1 for a momentum of 60 MeV/c), enabled us to pioneer a new frontier in analytical sciences. Here, we report a non-destructive elemental analysis using µ− capture. Controlling muon momentum from 32.5 to 57.5 MeV/c, we successfully demonstrate a depth-profile analysis of light elements (B, C, N, and O) from several mm-thick layered materials and non-destructive bulk analyses of meteorites containing organic materials. Muon beam analysis, enabling a bulk analysis of light to heavy elements without severe radioactivation, is a unique analytical method complementary to other non-destructive analyses. Furthermore, this technology can be used as a powerful tool to identify the content and distribution of organic components in future asteroidal return samples. PMID:24861282

  4. The fine grained detector readout electronics

    NASA Astrophysics Data System (ADS)

    Retière, F.; T2K/FGD Collaboration

    2010-11-01

    The Fine Grained Detector (FGD) readout electronics was designed to record a snapshot of the detector activity before, during and after the neutrino beam spill produced by the J-PARC accelerator complex in Tokai, Japan. The FGD is a key element of T2K near detector currently being constructed. It will act as an active target detecting charged particles produced within its scintillator bars. The original feature of the FGD electronics is to readout Multi-Pixel Photon Counters by recording waveforms using Switch Capacitor Array chips (AFTER ASIC) designed for T2K Time Projection Chamber. In these proceedings, we describe the architecture of the FGD electronics. Beam results show that the physics requirements are met or exceeded. The relatively slow sampling frequency of the AFTER ASIC does not impair the timing resolution significantly. In addition, the very good efficiency of the system for detecting Michel electrons produced by pions or muons decay has been demonstrated.

  5. Theoretical study of structure and production of F19Λ as a gateway to sd-shell hypernuclei

    NASA Astrophysics Data System (ADS)

    Umeya, Atsushi; Motoba, Toshio

    2016-10-01

    Energy level structures of the typical light sd-shell hypernucleus F19Λ, together with 18F, have been studied in detail with the multi-configuration shell model. Both positive-parity and negative-parity nuclear core excitations are fully taken into account by removing the spurious center-of-mass excitation effects. Corresponding to the J-PARC proposal of the 19F (K- ,π- γ) F19Λ experiment, the production cross sections have been estimated extensively, including the angular distributions. Starting with the elementary amplitudes for the K- n → Λπ- process, the microscopic DWIA calculations at high energy kaon momenta up to 1.8 GeV / c have been carried out for the first time. The calculated wave functions are also used to estimate the electromagnetic transition probabilities for both 18F and F19Λ. The detailed γ-decay schemes are presented and discussed.

  6. The 3-D Navier-Stokes analysis of crossing, glancing shocks/turbulent boundary layer interactions

    NASA Technical Reports Server (NTRS)

    Reddy, D. R.

    1991-01-01

    Three dimensional viscous flow analysis is performed for a configuration where two crossing and glancing shocks interact with a turbulent boundary layer. A time marching 3-D full Navier-Stokes code, called PARC3D, is used to compute the flow field, and the solution is compared to the experimental data obtained at the NASA Lewis Research Center's 1 x 1 ft supersonic wind tunnel facility. The study is carried out as part of the continuing code assessment program in support of the generic hypersonic research at NASA Lewis. Detailed comparisons of static pressure fields and oil flow patterns are made with the corresponding solution on the wall containing the shock/boundary layer interaction in an effort to validate the code for hypersonic inlet applications.

  7. 3-D Navier-Stokes analysis of crossing, glancing shocks/turbulent boundary layer interactions

    NASA Technical Reports Server (NTRS)

    Reddy, D. R.

    1991-01-01

    Three dimensional viscous flow analysis is performed for a configuration where two crossing and glancing shocks interact with a turbulent boundary layer. A time marching 3-D full Navier-Stokes code, called PARC3D, is used to compute the flow field, and the solution is compared to the experimental data obtained at the NASA Lewis Research Center's 1 x 1 ft supersonic wind tunnel facility. The study is carried out as part of the continuing code assessment program in support of the generic hypersonic research at NASA Lewis. Detailed comparisons of static pressure fields and oil flow patterns are made with the corresponding solution on the wall containing the shock/boundary layer interaction in an effort to validate the code for hypersonic inlet applications.

  8. The Study of Interpenetration Length between dPS Films and PS-grafted Layers

    NASA Astrophysics Data System (ADS)

    Lee, Hoyeon; Jo, Seongjun; Hirata, Toyoaki; Yamada, Norifumi L.; Tanaka, Keiji; Ryu, Du Yeol

    In polymer thin film system, the type of interfacial interaction is a critical parameter to determining the thermal and physical properties of polymer films. Interestingly, the interfacial energy of grafted substrates with polymer chains is remarkably altered by simply controlling grafting density, which has been referred to as autophobicity. In this study, we investigated the interpenetrating interfaces between deuterated polystyrene (dPS) and grafted substrates with the same chemical identity. PS-grafted substrates were prepared using a grafting-to approach with hydroxyl end-functionalized polystyrene (PSOH) in a dry brush regime, where the brush thickness and grafting density were determined based on the chain length (or molecular weight, Mn) of PSOHs. The interpenetration lengths (ξ) at interfaces between dPS and PS-grafted layers were characterized using neutron reflectivity (NR) measurements (performed at the SOFIA beam-line at J-PARC, Japan). Academic adviser.

  9. Numerical investigation of two- and three-dimensional heat transfer in expander cycle engines

    NASA Technical Reports Server (NTRS)

    Burch, Robert L.; Cheung, Fan-Bill

    1993-01-01

    The concept of using tube canting for enhancing the hot-side convective heat transfer in a cross-stream tubular rocket combustion chamber is evaluated using a CFD technique in this study. The heat transfer at the combustor wall is determined from the flow field generated by a modified version of the PARC Navier-Stokes Code, using the actual dimensions, fluid properties, and design parameters of a split-expander demonstrator cycle engine. The effects of artificial dissipation on convergence and solution accuracy are investigated. Heat transfer results predicted by the code are presented. The use of CFD in heat transfer calculations is critically examined to demonstrate the care needed in the use of artificial dissipation for good convergence and accurate solutions.

  10. Antimicrobial resistance and molecular typing of pseudomonas aeruginosa isolated from surgical wounds in Lagos, Nigeria.

    PubMed

    Smith, Stella; Ganiyu, Olaniyi; John, Rachael; Fowora, Muinah; Akinsinde, Kehinde; Odeigah, Peter

    2012-01-01

    The aim of the study was to determine the resistance patterns of Pseudomonas aeruginosa isolates recovered from patients with surgical wounds in hospitals and also to investigate their epidemiological relatedness using molecular typing techniques. Twenty Pseudomonas sp. isolated from surgical wounds were subjected to antibiotic susceptibility testing by disk diffusion, plasmid profile, SDS-PAGE and PCR using the parC, gyr A gene and RAPD using the 1254 primer. The isolates showed resistance to 12 different antibiotics with six being 100% resistant. Plasmids were detected in 16 (80%) of the isolates. The RAPD-PCR using the primer 1254, SDS-PAGE classified the 20 Pseudomonas spp. into 5 and 6 types respectively. Pseudomona aeruginosa strains isolated from surgical wounds were generally resistant to a broad range of antibiotics and this is rather worrisome. The typing techniques classified the 20 isolates into 5 and 6 groups. PMID:22837123

  11. Comparative study of turbulence models in predicting hypersonic inlet flows

    NASA Technical Reports Server (NTRS)

    Kapoor, Kamlesh; Anderson, Bernhard H.; Shaw, Robert J.

    1992-01-01

    A numerical study was conducted to analyze the performance of different turbulence models when applied to the hypersonic NASA P8 inlet. Computational results from the PARC2D code, which solves the full two-dimensional Reynolds-averaged Navier-Stokes equation, were compared with experimental data. The zero-equation models considered for the study were the Baldwin-Lomax model, the Thomas model, and a combination of the Baldwin-Lomax and Thomas models; the two-equation models considered were the Chien model, the Speziale model (both low Reynolds number), and the Launder and Spalding model (high Reynolds number). The Thomas model performed best among the zero-equation models, and predicted good pressure distributions. The Chien and Speziale models compared very well with the experimental data, and performed better than the Thomas model near the walls.

  12. A comparative study of turbulence models in predicting hypersonic inlet flows

    NASA Technical Reports Server (NTRS)

    Kapoor, Kamlesh

    1993-01-01

    A computational study has been conducted to evaluate the performance of various turbulence models. The NASA P8 inlet, which represents cruise condition of a typical hypersonic air-breathing vehicle, was selected as a test case for the study; the PARC2D code, which solves the full two dimensional Reynolds-averaged Navier-Stokes equations, was used. Results are presented for a total of six versions of zero- and two-equation turbulence models. Zero-equation models tested are the Baldwin-Lomax model, the Thomas model, and a combination of the two. Two-equation models tested are low-Reynolds number models (the Chien model and the Speziale model) and a high-Reynolds number model (the Launder and Spalding model).

  13. Comparative study of turbulence models in predicting hypersonic inlet flows

    NASA Technical Reports Server (NTRS)

    Kapoor, Kamlesh; Anderson, Bernhard H.; Shaw, Robert J.

    1992-01-01

    A numerical study was conducted to analyze the performance of different turbulence models when applied to the hypersonic NASA P8 inlet. Computational results from the PARC2D code, which solves the full two-dimensional Reynolds-averaged Navier-Stokes equation, were compared with experimental data. The zero-equation models considered for the study were the Baldwin-Lomax model, the Thomas model, and a combination of the Baldwin-Lomax and Thomas models; the two-equation models considered were the Chien model, the Speziale model (both low Reynolds number), and the Launder and Spalding model (high Reynolds number). The Thomas model performed best among the zero-equation models, and predicted good pressure distributions. The Chien and Speziale models compared wery well with the experimental data, and performed better than the Thomas model near the walls.

  14. Production and decay of charmed baryons

    NASA Astrophysics Data System (ADS)

    Hosaka, Atsushi; Hiyama, Emiko; Kim, SangHo; Kim, Hyun-Chul; Nagahiro, Hideko; Noumi, Hiroyuki; Oka, Makoto; Shirotori, Kotaro; Yoshida, Tetsuya; Yasui, Shigehiro

    2016-10-01

    In this paper, we discuss reactions involving charmed baryons to explore their unique features. A well known phenomenon, the separation of the two internal motions of the ρ and λ types of a three-quark system is revisited. First we discuss the mass spectrum of low lying excitations as function of the heavy quark mass, smoothly connecting the SU (3) and heavy quark limits. The properties of these modes can be tested in the production and decay reactions of the baryons. For production, we consider a one step process which excites dominantly λ modes. We find abundant production rates for some of the excited states. For decay, we study a pion emission process which provides a clean tool to test the structure of heavy quark systems due to the well controlled low energy dynamics of pions and quarks. Both production and decay of charmed baryons are issues for future experiments at J-PARC.

  15. Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease.

    PubMed

    Lock-Johansson, Sofie; Vestbo, Jørgen; Sorensen, Grith Lykke

    2014-11-25

    Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted researchers to investigate a multitude of surrogate biomarkers of disease for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary and activation-regulated chemokine (PARC/CCL-18)) and systemic inflammatory biomarkers (C-reactive protein (CRP) and fibrinogen) with COPD. The relevance of these biomarkers for COPD is discussed in terms of their biological plausibility, their independent association to disease and hard clinical outcomes, their modification by interventions, and whether changes in clinical outcomes are reflected by changes in the biomarker.

  16. Development of a cryogenic load frame for the neutron diffractometer at Takumi in Japan Proton Accelerator Research Complex.

    PubMed

    Jin, Xinzhe; Nakamoto, Tatsushi; Harjo, Stefanus; Hemmi, Tsutomu; Umeno, Takahiro; Ogitsu, Toru; Yamamoto, Akira; Sugano, Michinaka; Aizawa, Kazuya; Abe, Jun; Gong, Wu; Iwahashi, Takaaki

    2013-06-01

    To prepare for projects such as the Large Hadron Collider upgrade, International Thermonuclear Experimental Reactor and Demonstration reactor, it is important to form a clear understanding of stress-strain properties of the materials that make up superconducting magnets. Thus, we have been studying the mechanical properties of superconducting wires using neutron diffraction measurements. To simulate operational conditions such as temperature, stress, and strain, we developed a cryogenic load frame for stress-strain measurements of materials using a neutron diffractometer at Japan Proton Accelerator Research Complex (J-PARC) Takumi beam line. The maximum load that can be applied to a sample using an external driving machine is 50 kN. Using a Gifford-MacMahon cryocooler, samples can be measured down to temperatures below 10 K when loaded. In the present paper, we describe the details of the cryogenic load frame with its test results by using type-304 stainless steel wire.

  17. Neutron diffraction measurement of internal strain in the first Japanese ITER CS conductor sample

    NASA Astrophysics Data System (ADS)

    Hemmi, T.; Harjo, S.; Nunoya, Y.; Kajitani, H.; Koizumi, N.; Aizawa, K.; Machiya, S.; Osamura, K.

    2013-08-01

    Several conductor samples were fabricated and tested in the SULTAN facility at CRPP for ITER Central Solenoid (CS) conductor qualification. From the result of the cyclic testing on the first and second conductor samples named CSJA01 and CSJA02, continuous linear degradation of the current sharing temperature (Tcs) was found. From the result of the visual inspection, a large deflection on the lower loading side (LLS) in the high field zone (HFZ) was observed. The bending strain of the strands cannot be evaluated from only the deflection obtained visually. To evaluate the strain of strands in CSJA01 quantitatively, a neutron diffraction measurement of the CSJA01 left leg was performed using the engineering materials diffractometer ‘Takumi’ in J-PARC. From the result, the large bending strain at the LLS in the HFZ was found. Therefore, the Tcs degraded position in the conductor sample due to the cyclic testing can be determined.

  18. Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex

    PubMed Central

    Veselkov, Dennis A.; Laponogov, Ivan; Pan, Xiao-Su; Selvarajah, Jogitha; Skamrova, Galyna B.; Branstrom, Arthur; Narasimhan, Jana; Prasad, Josyula V. N. Vara; Fisher, L. Mark; Sanderson, Mark R.

    2016-01-01

    Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of common infections, including pulmonary pneumonia, bloodstream infections and meningitis. Certain strains of Klebsiella have become highly resistant to antibiotics. Despite the vast amount of research carried out on this class of bacteria, the molecular structure of its topoisomerase IV, a type II topoisomerase essential for catalysing chromosomal segregation, had remained unknown. In this paper, the structure of its DNA-cleavage complex is reported at 3.35 Å resolution. The complex is comprised of ParC breakage-reunion and ParE TOPRIM domains of K. pneumoniae topoisomerase IV with DNA stabilized by levofloxacin, a broad-spectrum fluoroquinolone antimicrobial agent. This complex is compared with a similar complex from Streptococcus pneumoniae, which has recently been solved. PMID:27050128

  19. 2 MW upgrade of the Fermilab Main Injector

    SciTech Connect

    Weiren Chou

    2003-06-04

    In January 2002, the Fermilab Director initiated a design study for a high average power, modest energy proton facility. An intensity upgrade to Fermilab's 120-GeV Main Injector (MI) represents an attractive concept for such a facility, which would leverage existing beam lines and experimental areas and would greatly enhance physics opportunities at Fermilab and in the U.S. With a Proton Driver replacing the present Booster, the beam intensity of the MI is expected to be increased by a factor of five. Accompanied by a shorter cycle, the beam power would reach 2 MW. This would make the MI a more powerful machine than the SNS or the J-PARC. Moreover, the high beam energy (120 GeV) and tunable energy range (8-120 GeV) would make it a unique high power proton facility. The upgrade study has been completed and published. This paper gives a summary report.

  20. A new polarimetric active radar calibrator and calibration technique

    NASA Astrophysics Data System (ADS)

    Tang, Jianguo; Xu, Xiaojian

    2015-10-01

    Polarimetric active radar calibrator (PARC) is one of the most important calibrators with high radar cross section (RCS) for polarimetry measurement. In this paper, a new double-antenna polarimetric active radar calibrator (DPARC) is proposed, which consists of two rotatable antennas with wideband electromagnetic polarization filters (EMPF) to achieve lower cross-polarization for transmission and reception. With two antennas which are rotatable around the radar line of sight (LOS), the DPARC provides a variety of standard polarimetric scattering matrices (PSM) through the rotation combination of receiving and transmitting polarization, which are useful for polarimatric calibration in different applications. In addition, a technique based on Fourier analysis is proposed for calibration processing. Numerical simulation results are presented to demonstrate the superior performance of the proposed DPARC and processing technique.

  1. Automated Derivation of Complex System Constraints from User Requirements

    NASA Technical Reports Server (NTRS)

    Muery, Kim; Foshee, Mark; Marsh, Angela

    2006-01-01

    International Space Station (ISS) payload developers submit their payload science requirements for the development of on-board execution timelines. The ISS systems required to execute the payload science operations must be represented as constraints for the execution timeline. Payload developers use a software application, User Requirements Collection (URC), to submit their requirements by selecting a simplified representation of ISS system constraints. To fully represent the complex ISS systems, the constraints require a level of detail that is beyond the insight of the payload developer. To provide the complex representation of the ISS system constraints, HOSC operations personnel, specifically the Payload Activity Requirements Coordinators (PARC), manually translate the payload developers simplified constraints into detailed ISS system constraints used for scheduling the payload activities in the Consolidated Planning System (CPS). This paper describes the implementation for a software application, User Requirements Integration (URI), developed to automate the manual ISS constraint translation process.

  2. The French Balloon Program : overview of the 200 -2010 period and strategy for the future

    NASA Astrophysics Data System (ADS)

    Clair, Marie-Anne; Vassaux, Didier

    Since its establishment in 1962, the Centre National d'Etudes Spatiales (CNES) has been supporting scientific ballooning, which remains the most cost effective means to support near space science. This paper will give an overview of the CNES capabilities and services for operational balloon activities, and on the on going development to improve them. Since these last two years, the most important balloon campaigns will be presented : atmospheric research and satellite validation with zero pressure balloons launched from Esrange facility (Kiruna); Pacific Asian Regional Campaign (T-PARC) from Hawaii for studies of typhoon genesis above the Asian Coasts in collaboration with NCAR; validation of super pressure balloon system for the Concordiasi campaign which is planned in Antarctica from MacMurdo US station at the end of 2010 (Metop/IASI satellite validation and ozone depletion studies) and flights of the Fireball stabilized gondola for UV astronomy in collaboration with Caltech and CNRS/LAM.

  3. Paramagnetic muon states in mesoporous carbon materials

    NASA Astrophysics Data System (ADS)

    Macrae, R. M.; Upchurch, C.; Rose, D. K.; Miyake, Y.; Koda, A.; Lord, J. S.; Shuttleworth, P. S.

    2014-12-01

    We present results of longitudinal field repolarisation measurements carried out at J-PARC and ISIS on the "green" functional carbon materials Starbon 300 and Starbon 800, synthesized using starch as a template and subjected to pyrolysis treatments at different temperatures (300°C and 800°C respectively); pyrolysis at low temperature may be expected to yield a material retaining more of the "hydrophilic" properties of the original starch material in its chemically active voids, while high temperature pyrolysis may be expected to lead to "hydrophobic" voids and a more graphitic material. The hydrophilic material shows a larger repolarising fraction than the hydrophobic material, with a hyperfine constant on the order of 200-300 MHz. This is likely to be a superposition of the repolarisation of multiple radicals. Several candidate and model species are investigated through accompanying density functional theory calculations.

  4. Neutrino nuclear responses for double beta decays and astro neutrinos by charge exchange reactions

    NASA Astrophysics Data System (ADS)

    Ejiri, Hiroyasu

    2014-09-01

    Neutrino nuclear responses are crucial for neutrino studies in nuclei. Charge exchange reactions (CER) are shown to be used to study charged current neutrino nuclear responses associated with double beta decays(DBD)and astro neutrino interactions. CERs to be used are high energy-resolution (He3 ,t) reactions at RCNP, photonuclear reactions via IAR at NewSUBARU and muon capture reactions at MUSIC RCNP and MLF J-PARC. The Gamow Teller (GT) strengths studied by CERs reproduce the observed 2 neutrino DBD matrix elements. The GT and spin dipole (SD) matrix elements are found to be reduced much due to the nucleon spin isospin correlations and the non-nucleonic (delta isobar) nuclear medium effects. Impacts of the reductions on the DBD matrix elements and astro neutrino interactions are discussed.

  5. Medium Fidelity Simulation of Oxygen Tank Venting

    NASA Technical Reports Server (NTRS)

    Sweet, Adam; Kurien, James; Lau, Sonie (Technical Monitor)

    2001-01-01

    The item to he cleared is a medium-fidelity software simulation model of a vented cryogenic tank. Such tanks are commonly used to transport cryogenic liquids such as liquid oxygen via truck, and have appeared on liquid-fueled rockets for decades. This simulation model works with the HCC simulation system that was developed by Xerox PARC and NASA Ames Research Center. HCC has been previously cleared for distribution. When used with the HCC software, the model generates simulated readings for the tank pressure and temperature as the simulated cryogenic liquid boils off and is vented. Failures (such as a broken vent valve) can be injected into the simulation to produce readings corresponding to the failure. Release of this simulation will allow researchers to test their software diagnosis systems by attempting to diagnose the simulated failure from the simulated readings. This model does not contain any encryption software nor can it perform any control tasks that might be export controlled.

  6. Computational analysis of the flowfield of a two-dimensional ejector nozzle

    NASA Technical Reports Server (NTRS)

    Choi, Y. H.; Soh, W. Y.

    1990-01-01

    A time-iterative full Navier-Stokes code, PARC, is used to analyze the flowfield of a two-dimensional ejector nozzle system. A parametric study was performed for two controlling parameters, duct to nozzle area ratio and nozzle pressure ratio. Results show that there is an optimum area ratio for the efficient pumping of secondary flow. At high area ratios, a freestream flow passes directly through the mixing duct without giving adequate pumping. At low area ratios, the jet boundary blocks the incoming flow. The nozzle pressure ratio variation shows that the pumping rate increases as the pressure ratio increases, provided there is no interaction between the shroud wall and the shock cell structure.

  7. Non-destructive Elemental Analysis Using Negative Muon

    NASA Astrophysics Data System (ADS)

    Kubo, Michael K.

    2016-09-01

    A negative muon implanted into materials is captured by an atom and forms a muonic atom with emission of muonic X-rays. The X-ray energy is characteristic to the atomic number of the atom which captured the muon. By measuring the energy of the muonic X-ray induced by the negative muon implanted into the sample material with a kinetic energy tuned to stop at a chosen depth from the sample surface, the elemental composition of the sample at the specific depth from the surface is revealed. This elemental analysis method has unique in non-destructive, multi-element, and depth-selective characteristics. The method is being developed at the J-PARC/MUSE facility.

  8. A new X-ray fluorescence spectroscopy for extraterrestrial materials using a muon beam.

    PubMed

    Terada, K; Ninomiya, K; Osawa, T; Tachibana, S; Miyake, Y; Kubo, M K; Kawamura, N; Higemoto, W; Tsuchiyama, A; Ebihara, M; Uesugi, M

    2014-05-27

    The recent development of the intense pulsed muon source at J-PARC MUSE, Japan Proton Accelerator Research Complex/MUon Science Establishment (10(6) s(-1) for a momentum of 60 MeV/c), enabled us to pioneer a new frontier in analytical sciences. Here, we report a non-destructive elemental analysis using µ(-) capture. Controlling muon momentum from 32.5 to 57.5 MeV/c, we successfully demonstrate a depth-profile analysis of light elements (B, C, N, and O) from several mm-thick layered materials and non-destructive bulk analyses of meteorites containing organic materials. Muon beam analysis, enabling a bulk analysis of light to heavy elements without severe radioactivation, is a unique analytical method complementary to other non-destructive analyses. Furthermore, this technology can be used as a powerful tool to identify the content and distribution of organic components in future asteroidal return samples.

  9. HARP and NA61 (SHINE) hadron production experiments

    SciTech Connect

    Popov, Boris A.

    2009-11-25

    The hadroproduction experiments HARP and NA61 (SHINE) as well as their implications for neutrino physics are discussed. Recent HARP measurements have already been used for precise predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First preliminary data from NA61 are of significant importance for a precise prediction of a new neutrino beam at J-PARC to be used for the first stage of the T2K experiment. Both HARP and NA61 provide a large amount of input for validation and tuning of hadroproduction models in Monte-Carlo generators.

  10. Fixed-target hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2015-08-01

    Results from fixed-target hadroproduction experiments (HARP, MIPP, NA49 and NA61/SHINE) as well as their implications for cosmic ray and neutrino physics are reviewed. HARP measurements have been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve predictions of the muon yields in EAS and of the atmospheric neutrino fluxes as well as to help in the optimization of neutrino factory and super-beam designs. Recent measurements released by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment and for interpretation of EAS data. These hadroproduction experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  11. Hadron production experiments

    NASA Astrophysics Data System (ADS)

    Popov, Boris A.

    2013-02-01

    The HARP and NA61/SHINE hadroproduction experiments as well as their implications for neutrino physics are discussed. HARP measurements have already been used for predictions of neutrino beams in K2K and MiniBooNE/SciBooNE experiments and are also being used to improve the atmospheric neutrino flux predictions and to help in the optimization of neutrino factory and super-beam designs. First measurements released recently by the NA61/SHINE experiment are of significant importance for a precise prediction of the J-PARC neutrino beam used for the T2K experiment. Both HARP and NA61/SHINE experiments provide also a large amount of input for validation and tuning of hadron production models in Monte-Carlo generators.

  12. OXA-48 carbapenemase-producing Salmonella enterica serovar Kentucky isolate of sequence type 198 in a patient transferred from Libya to Switzerland.

    PubMed

    Seiffert, Salome N; Perreten, Vincent; Johannes, Sönke; Droz, Sara; Bodmer, Thomas; Endimiani, Andrea

    2014-01-01

    Here, we report a case of OXA-48-producing Salmonella enterica serovar Kentucky of sequence type 198 (ST198) from perianal screening cultures of a patient transferred from Libya to Switzerland. The blaOXA-48 gene was carried by Tn1999.2 and located on an ∼60-kb IncL/M plasmid. This Salmonella strain also possessed the blaVEB-8, aac(6)-Ib, tet(A), sul1, and mphA resistance genes and substitutions in GyrA (Ser83Phe and Asp87Asn) and ParC (Ser80Ile). This finding emphasizes that prompt screening strategies are essential to prevent the dissemination of carbapenemase producers imported from countries where they are endemic.

  13. A Full Navier-Stokes Analysis of Subsonic Diffuser of a Bifurcated 70/30 Supersonic Inlet for High Speed Civil Transport Application

    NASA Technical Reports Server (NTRS)

    Kapoor, Kamlesh; Anderson, Bernhard H.; Shaw, Robert J.

    1994-01-01

    A full Navier-Stokes analysis was performed to evaluate the performance of the subsonic diffuser of a NASA Lewis Research Center 70/30 mixed-compression bifurcated supersonic inlet for high speed civil transport application. The PARC3D code was used in the present study. The computations were also performed when approximately 2.5 percent of the engine mass flow was allowed to bypass through the engine bypass doors. The computational results were compared with the available experimental data which consisted of detailed Mach number and total pressure distribution along the entire length of the subsonic diffuser. The total pressure recovery, flow distortion, and crossflow velocity at the engine face were also calculated. The computed surface ramp and cowl pressure distributions were compared with experiments. Overall, the computational results compared well with experimental data. The present CFD analysis demonstrated that the bypass flow improves the total pressure recovery and lessens flow distortions at the engine face.

  14. Molecular Basis of Resistance to Selected Antimicrobial Agents in the Emerging Zoonotic Pathogen Streptococcus suis

    PubMed Central

    Gurung, Mamata; Tamang, Migma Dorji; Moon, Dong Chan; Kim, Su-Ran; Jeong, Jin-Ha; Jang, Geum-Chan; Jung, Suk-Chan; Park, Yong-Ho

    2015-01-01

    Characterization of 227 Streptococcus suis strains isolated from pigs during 2010 to 2013 showed high levels of resistance to clindamycin (95.6%), tilmicosin (94.7%), tylosin (93.8%), oxytetracycline (89.4%), chlortetracycline (86.8%), tiamulin (72.7%), neomycin (70.0%), enrofloxacin (56.4%), penicillin (56.4%), ceftiofur (55.9%), and gentamicin (55.1%). Resistance to tetracyclines, macrolides, aminoglycosides, and fluoroquinolone was attributed to the tet gene, erm(B), erm(C), mph(C), and mef(A) and/or mef(E) genes, aph(3′)-IIIa and aac(6′)-Ie-aph(2″)-Ia genes, and single point mutations in the quinolone resistance-determining region of ParC and GyrA, respectively. PMID:25903569

  15. Development of a cryogenic load frame for the neutron diffractometer at Takumi in Japan Proton Accelerator Research Complex

    SciTech Connect

    Jin, Xinzhe; Nakamoto, Tatsushi; Ogitsu, Toru; Yamamoto, Akira; Sugano, Michinaka; Harjo, Stefanus; Aizawa, Kazuya; Abe, Jun; Gong, Wu; Iwahashi, Takaaki; Hemmi, Tsutomu; Umeno, Takahiro

    2013-06-15

    To prepare for projects such as the Large Hadron Collider upgrade, International Thermonuclear Experimental Reactor and Demonstration reactor, it is important to form a clear understanding of stress-strain properties of the materials that make up superconducting magnets. Thus, we have been studying the mechanical properties of superconducting wires using neutron diffraction measurements. To simulate operational conditions such as temperature, stress, and strain, we developed a cryogenic load frame for stress-strain measurements of materials using a neutron diffractometer at Japan Proton Accelerator Research Complex (J-PARC) Takumi beam line. The maximum load that can be applied to a sample using an external driving machine is 50 kN. Using a Gifford-MacMahon cryocooler, samples can be measured down to temperatures below 10 K when loaded. In the present paper, we describe the details of the cryogenic load frame with its test results by using type-304 stainless steel wire.

  16. The new Cold Neutron Chopper Spectrometer at the Spallation Neutron Source -- Design and Performance

    SciTech Connect

    Ehlers, Georg; Podlesnyak, Andrey A.; Niedziela, Jennifer L.; Iverson, Erik B.; Sokol, Paul E.

    2011-01-01

    The design and performance of the new cold neutron chopper spectrometer (CNCS) at the Spallation Neutron Source in Oak Ridge are described. CNCS is a direct-geometry inelastic time-of-flight spectrometer, designed essentially to cover the same energy and momentum transfer ranges as IN5 at ILL, LET at ISIS, DCS at NIST, TOFTOF at FRM-II, AMATERAS at J-PARC, PHAROS at LANSCE, and NEAT at HZB, at similar energy resolution. Measured values of key figures such as neutron flux at sample position and energy resolution are compared between measurements and ray tracing Monte Carlo simulations, and good agreement (better than 20% of absolute numbers) has been achieved. The instrument performs very well in the cold and thermal neutron energy ranges, and promises to become a workhorse for the neutron scattering community for quasielastic and inelastic scattering experiments.

  17. The new cold neutron chopper spectrometer at the Spallation Neutron Source: Design and performance

    SciTech Connect

    Ehlers, G.; Podlesnyak, A. A.; Niedziela, J. L.; Iverson, E. B.; Sokol, P. E.

    2011-08-15

    The design and performance of the new cold neutron chopper spectrometer (CNCS) at the Spallation Neutron Source in Oak Ridge are described. CNCS is a direct-geometry inelastic time-of-flight spectrometer, designed essentially to cover the same energy and momentum transfer ranges as IN5 at ILL, LET at ISIS, DCS at NIST, TOFTOF at FRM-II, AMATERAS at J-PARC, PHAROS at LANSCE, and NEAT at HZB, at similar energy resolution. Measured values of key figures such as neutron flux at sample position and energy resolution are compared between measurements and ray tracing Monte Carlo simulations, and good agreement (better than 20% of absolute numbers) has been achieved. The instrument performs very well in the cold and thermal neutron energy ranges, and promises to become a workhorse for the neutron scattering community for quasielastic and inelastic scattering experiments.

  18. Définir les choix à risque: l'éthique et les effets des décisions organisationnelles.

    PubMed

    Warren, Marika

    2016-07-01

    Les choix de vivre « à risque » sont complexes et difficiles. Ils peuvent être structurés par les politiques organisationnelles. Certaines personnes veulent vraiment vivre dans des situations à haut risque ou perçues comme telles parce qu'elles en tirent un avantage important. Cependant, il est probable que ces choix dépendent en grande partie du contexte et qu'ils ne se soient pas posés dans une autre situation. L'article plaide pour la responsabilité d'être attentif aux effets des décisions organisationnelles sur les choix de vivre à risque et sur la répartition globale du risque.

  19. [The VAMP device. Benefits for the critical patient].

    PubMed

    García Morón, Nuria; Chacón Jordán, Encarnación; Fernández Moreno, Inmaculada; Granero Lázaro, Alberto

    2003-09-01

    Taking blood samples by means of conventional intravascular devices requires throwing away an initial volume of mixed blood and serum which comprises between 24-26% of the volume of blood extracted from the patient admitted into an intensive care ward. At present time there exists a device with a reservoir, VAMP, which permits one to obtain blood samples without having to waste this initial volume. The working hypothesis poses that the use of the VAMP device decreases the risk of transfusion. This study has a random prospective design. This study subjects are 58 patients admitted in the intensive care ward at the Parc Taulí Corporation distributed in a control group which made use of a conventional device and a VAMP group which made use of the device having a reservoir. The study used a data recordsheet. Statistical calculations were carried out on the SPSS program.

  20. The old man and the sea.

    SciTech Connect

    Geesaman, D. F.

    2010-01-01

    The summary of this presentation is: (1) the origin and structure of the sea remain critical themes in the physics of the nucleon and nucleus; (2) We need to push to higher x values and E906/SeaQuest is especially well suited for this. We start this summer and run for two years; (3) The other really key measurement is improved precision in the spin carried by the sea quarks and the spin-correlations in the sea - COMPASS, RHIC, J-PARC, JLAB 12 GeV.; and (4) This is difficult and may require the next generation of polarized Drell-Yan experiments. Whatever we measure, Tony Thomas will have thought of it first and helped stimulate the experiments.