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Sample records for parc electronucleaire francais

  1. C-Band PARC Manual

    DTIC Science & Technology

    1992-05-01

    unpredictable flight path of an airborne radar complicates its pointing. An alternative for dihedral and trihedral corner reflectors is a PARC. A PARC...TNO-FEL PARC 9 3 MEASUREMENT RESULTS 11 3.1 Power consumption 11 3.2 Linearity 11 3.3 Crosstalk 13 3.4 Frequency response 14 3.5 Radar cross section ...calibration of air- and spacebome radars commonly used in remote sensing one needs point targets with an RCS ( Radar Cross Section ) which is large

  2. Le Francais Courant: Part V, French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Instructional objectives of the Dade County Public Schools Quinmester Program in French for use with "Le Francais Courant: Part 5" focus on the development of mastery of the basic numbering system and other grammatical structures. Structures include the formation of the present tense of the irregular verbs…

  3. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  4. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  5. Systematic in J-PARC/Hyper-K

    SciTech Connect

    Minamino, Akihiro

    2015-05-15

    The Hyper-Kamiokande (Hyper-K) detector is a next generation underground water Chrenkov detector. The J-PARC to Hyper-K experiment has good potential for precision measurements of neutrino oscillation parameters and discovery reach for CP violation in the lepton sector. With a total exposure of 10 years to a neutrino beam produced by the 750 kW J-PARC proton synchrotron, it is expected that the CP phase δ can be determined to better than 18 degree for all possible values of δ if sin{sup 2} 2θ{sub 13} > 0.03 and the mass hierarchy is known. Control of systematic uncertainties is critical to make maximum use of the Hyper-K potential. Based on learning from T2K experience, a strategy to reduce systematic uncertainties in J-PARC/Hyper-K are developed.

  6. A PARC system for terminal docking

    NASA Technical Reports Server (NTRS)

    Gilbert, John A.; Bankston, Cheryl D.

    1991-01-01

    A Panoramic viewing system for Automated Rendezvous and Capture (PARC) has been proposed as a visual information feedback system for terminal docking/berthing. The system relies on a unique Panoramic Annular Lens (PAL) which captures an image of its surroundings in real time. This paper describes the evolution of the PAL along with technical details of its imaging capabilities. Several examples are given of radial metrology, where PAL imaging systems are used to perform visual inspections and measurements. Digital image acquisition and processing techniques, used to interpret various features appearing in the images and to transform images for improved human viewing, are also included. These discussions are followed by a potential application for PARC involving berthing of active and passive mechanical assemblies associated with Space Station Freedom.

  7. Design concept for the microwave interrogation structure in PARCS

    NASA Technical Reports Server (NTRS)

    Dick, G. J.; Klipstein, W. M.; Heavner, T. P.; Jefferts, S. R.

    2002-01-01

    In this paper we will describe key aspects of the conceptual design of the microwave interrogation structure in the laser-cooled cesium frequency standard that is part of the Primary Atomic Reference Clock in Space (PARCS) experiment.

  8. Design concept for the microwave interrogation structure in PARCS

    NASA Technical Reports Server (NTRS)

    Dick, G. J.; Klipstein, W. M.; Heavner, T. P.; Jefferts, S. R.

    2002-01-01

    In this paper we will describe key aspects of the conceptual design of the microwave interrogation structure in the laser-cooled cesium frequency standard that is part of the Primary Atomic Reference Clock in Space (PARCS) experiment.

  9. Features Of The J-PARC Linac

    SciTech Connect

    Kobayashi, Tetsuya

    2011-06-01

    Japan Proton Accelerator Research Complex (J-PARC) will be one of the highest intensity proton accelerators in the world aiming to realize 1 MW class of the beam power. The accelerator consists of a 400-MeV linac, a 3-GeV rapid-cycling synchrotron (RCS) and a main ring synchrotron (MR), and the accelerated beam is applied to several experimental facilities. The linac, which is the injector for the RCS, has about 50 cavity modules to accelerate the beam up to 400 MeV. The acceleration field error in all of them should be within {+-}1% in amplitude and {+-}1 degree in phase because the momentum spread of the RCS injection beam is required to be within 0.1%. For the cavity field stabilization, a high-stable optical signal distribution system is used as the RF reference, and sophisticated digital feedback and feed-forward system is working well in the low level RF control system. Consequently the providing beam to the RCS is very stable, and the beam commissioning and the experiments of the application facilities have been progressed steadily.

  10. J-PARC accelerator and neutrino beamline upgrade programme

    NASA Astrophysics Data System (ADS)

    Friend, M.

    2017-09-01

    The 30 GeV proton beam from the J-PARC Main Ring (MR) accelerator is used to produce a world-class conventional neutrino beam – the neutrino source for the J-PARC long-baseline neutrino programme, including the current T2K experiment and proposed future experiments. Planned upgrades to increase the beam power of the MR from the current ∼400 kW to the design power of 750 kW and beyond, to 1.3+ MW, are underway. These include hardware modifications, such as upgrades of the MR magnet power supplies, RF systems, and feedback systems, as well as a change of the MR beam betatron tune point. Upgrades to the neutrino beamline, such as to the proton beam monitoring, horns, and radioactive material handling, will also be required to accommodate the increased proton beam power. An overview of planned J-PARC MR and neutrino facility upgrades is given.

  11. La culture politique du Mouvement Quebec Francais [The Political Culture of the "French Quebec Movement"].

    ERIC Educational Resources Information Center

    Turcotte, Denis

    This study of the "Mouvement Quebec Francais (MQF)" covers the period from March 1971 through Spring 1974. The fundamental postulate of the study is that if the political culture is internalized by individuals, it is at the same time borne by groups. The study of groups represents, therefore, a good vehicle to reveal the most significant…

  12. Le "Francais Populaire" and French as a Second Language: A Comparative Study of Language Simplification.

    ERIC Educational Resources Information Center

    Kenemer, Virginia Lynn

    The French of English speaking students of French as a second language is compared with "francais populaire" (FP) in order to determine similarities in their tendency toward simplified grammar and morphology. Simplifying characteristics that are typical of FP were obtained from French working class sources, while simplification patterns…

  13. The Lycee Francais in New York: A Showcase for the French-Speaking Community

    ERIC Educational Resources Information Center

    Michel, Florence

    2004-01-01

    In New York they say that the architecture of the new "Lycee francais" (serving French students from kindergarten through upper secondary education) was inspired by the rationalism of Descartes. What is beyond doubt, however, is that the design and materials chosen by the American firm of architects, "Polshek Partnership…

  14. The Lycee Francais in New York: A Showcase for the French-Speaking Community

    ERIC Educational Resources Information Center

    Michel, Florence

    2004-01-01

    In New York they say that the architecture of the new "Lycee francais" (serving French students from kindergarten through upper secondary education) was inspired by the rationalism of Descartes. What is beyond doubt, however, is that the design and materials chosen by the American firm of architects, "Polshek Partnership…

  15. Muonium in J-PARC; from fundamental to application

    NASA Astrophysics Data System (ADS)

    Shimomura, K.

    2015-08-01

    At J-PARC, the muon science facility (MUSE) was successfully constructed in the Materials and Life Science Facility (MLF), and three scientific activities is now ongoing related muonium (Mu) from fundamental to application; 1) Mu hyperfine structure measurement (MuSEUM), 2) Ultra Slow Muon Microscope (USMM) and 3) muon g-2 and EDM measurement. Here, we will report present status of each activity.

  16. Annual Report: 2014: Partners in Amphibian and Reptile Conservation (PARC)

    USGS Publications Warehouse

    Weir, Linda A.; Nanjappa, P.; Apodaca, J. J.; Williams, J.

    2015-01-01

    Partners in Amphibian and Reptile Conservation (PARC) was established in 1999 to address the widespread declines, extinctions, and range reductions of amphibians and reptiles, with a focus on conservation of taxa and habitats in North America. Amphibians and reptiles are affected by a broad range of human activities, both as incidental effects of habitat alteration and direct effects from overexploitation; these animals are also burdened by humans attitudes – that amphibians and reptiles are either dangerous or of little environmental or economic value. However, PARC members understand these taxa are important parts of our natural and cultural heritage and they serve important roles in ecosystems throughout the world. With many amphibians and reptiles classified as threatened with extinction, conservation to ensure healthy populations of these animals has never been more important. As you will see herein, PARC’s 15th anniversary has been marked with major accomplishments and an ever-increasing momentum. With your help, PARC can continue to build on its successes and protect these vital species.

  17. High-energy hadron physics at J-PARC

    SciTech Connect

    Kumano, S.

    2008-10-13

    The J-PARC facility is near completion and experiments will start in 2009 on nuclear and particle physics projects. In this article, the J-PARC facility is introduced, and possible projects are discussed in high-energy hadron physics by using the primary proton beam of 30-50 GeV. There are proposed experiments on charm-production and Drell-Yan processes as well as single spin asymmetries for investigating quark and gluon structure of the nucleon and nuclei. Parton-energy loss could be studied in the Drell-Yan processes. There is also a proposal on hadron-mass modifications in a nuclear medium by using the proton beam. In addition, possible topics include transition from hadron to quark degrees of freedom by elastic pp scattering, color transparency by (p,2p), short-range correlation in nuclear force by (p,2pN), tensor structure functions for spin-one hadrons, fragmentation functions, and generalized partem distributions in the ERBL region although proposals are not written on these projects. If proton-beam polarization is attained, it is possible to investigate details of nucleon spin structure. In the last part of this article, our own studies are explained on partem distribution functions in connection with the J-PARC projects.

  18. What Does Due Process Do? "PARC v. Commonwealth of Pennsylvania" Reconsidered.

    ERIC Educational Resources Information Center

    Kirp, David L.; Jensen, Donald N.

    The landmark judicial decision "Pennsylvania Association for Retarded Children (PARC) v. Commonwealth of Pennsylvania" exemplifies a growing tendency toward the legal redefinition of educational issues previously committed to professional or bureaucratic solutions. During the decade since the "PARC" decision went into effect,…

  19. Performance of the PARCS Testbed Cesium Fountain Frequency Standard

    NASA Technical Reports Server (NTRS)

    Enzer, Daphna G.; Klipstein, William M.

    2004-01-01

    A cesium fountain frequency standard has been developed as a ground testbed for the PARCS (Primary Atomic Reference Clock in Space) experiment, an experiment intended to fly on the International Space Station. We report on the performance of the fountain and describe some of the implementations motivated in large part by flight considerations, but of relevance for ground fountains. In particular, we report on a new technique for delivering cooling and trapping laser beams to the atom collection region, in which a given beam is recirculated three times effectively providing much more optical power than traditional configurations. Allan deviations down to 10 have been achieved with this method.

  20. A Study of Polarized Proton Acceleration in J-PARC

    SciTech Connect

    Luccio, A. U.; Bai, M.; Roser, T.; Molodojentsev, A.; Ohmori, C.; Sato, H.; Hatanaka, K.

    2007-06-13

    We have studied the feasibility of polarized proton acceleration in rhe J-PARC accelerator facility, consisting of a 400 MeV linac, a 3 GeV rapid cycling synchrotron (RCS) and a 50 GeV synchrotron (MR). We show how the polarization of the beam can be preserved using an rf dipole in the RCS and two superconductve partial helical Siberian snakes in the MR. The lattice of the MR will be modified with the addition of quadrupoles to compensate for the focusing properties of the snakes.

  1. A STUDY OF POLARIZED PROTON ACCELERATION IN J-PARC.

    SciTech Connect

    LUCCIO, A.U.; BAI, M.; ROSER, T.

    2006-10-02

    We have studied the feasibility of polarized proton acceleration in rhe J-PARC accelerator facility, consisting of a 400 MeV linac, a 3 GeV rapid cycling synchrotron (RCS) and a 50 GeV synchrotron (MR). We show how the polarization of the beam can be preserved using an rf dipole in the RCS and two superconductive partial helical Siberian snakes in the MR. The lattice of the MR will be modified with the addition of quadrupoles to compensate for the focusing properties of the snakes.

  2. TRACE/PARCS modelling of rips trip transients for Lungmen ABWR

    SciTech Connect

    Chang, C. Y.; Lin, H. T.; Wang, J. R.; Shih, C.

    2012-07-01

    The objectives of this study are to examine the performances of the steady-state results calculated by the Lungmen TRACE/PARCS model compared to SIMULATE-3 code, as well as to use the analytical results of the final safety analysis report (FSAR) to benchmark the Lungmen TRACE/PARCS model. In this study, three power generation methods in TRACE were utilized to analyze the three reactor internal pumps (RIPs) trip transient for the purpose of validating the TRACE/PARCS model. In general, the comparisons show that the transient responses of key system parameters agree well with the FSAR results, including core power, core inlet flow, reactivity, etc. Further studies will be performed in the future using Lungmen TRACE/PARCS model. After the commercial operation of Lungmen nuclear power plant, TRACE/PARCS model will be verified. (authors)

  3. Proposal to Participate in J-Parc KL Experiment

    SciTech Connect

    Campbell, Myron; Tecchio, Monica

    2013-02-03

    During the previous grant period we have been working on the J-PARC KL E14 (KOTO) experiment with the goal to discover and measure the rate of the rare decay neutral kaons to a pion and two neutrinos. This CP-violating flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement to the branching ratio, which in the Standard Model predicted to be about 2.80E-11. The experiment is expected to observe 100 events at the Standard Model branching ratio for a 10% measurement. The experiment is a follow-up to E391a at KEK and has been approved as experiment E14 at J-PARC. The main barrel vacuum vessel, the charged veto detectors, and the main barrel photon veto system will be reused from E391a. The main calorimeter has been replaced with Cesium Iodide crystals that are both smaller to provide improved shower reconstruction and longer to prevent energy leakage out of the back of the calorimeter. New trigger and data acquisitions electronics will be used.

  4. Serum PARC/CCL-18 Concentrations and Health Outcomes in Chronic Obstructive Pulmonary Disease

    PubMed Central

    Sin, Don D.; Miller, Bruce E.; Duvoix, Annelyse; Man, S. F. Paul; Zhang, Xuekui; Silverman, Edwin K.; Connett, John E.; Anthonisen, Nicholas A.; Wise, Robert A.; Tashkin, Donald; Celli, Bartolome R.; Edwards, Lisa D.; Locantore, Nicholas; MacNee, William; Tal-Singer, Ruth; Lomas, David A.

    2011-01-01

    Rationale: There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. Objectives: To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD and to determine their relationship to clinical end points of hospitalization and mortality. Methods: PARC/CCL-18 was measured in serum samples from individuals who participated in the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) and LHS (Lung Health Study) studies and a prednisolone intervention study. Measurements and Main Results: Serum PARC/CCL-18 levels were higher in subjects with COPD than in smokers or lifetime nonsmokers without COPD (105 vs. 81 vs. 80 ng/ml, respectively; P < 0.0001). Elevated PARC/CCL-18 levels were associated with increased risk of cardiovascular hospitalization or mortality in the LHS cohort and with total mortality in the ECLIPSE cohort. Conclusions: Serum PARC/CCL-18 levels are elevated in COPD and track clinical outcomes. PARC/CCL-18, a lung-predominant chemokine, could be a useful blood biomarker in COPD. Clinical trial registered with www.clinicaltrials.gov (NCT 00292552). PMID:21216880

  5. Precision spectroscopy of kaonic {sup 3}He X-rays at J-PARC

    SciTech Connect

    Sato, M.; Fujiwara, Y.; Hashimoto, T.; Hayano, R. S.; Ishikawa, T.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Wuenschek, B.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.; Vidal, A. Romero

    2011-10-24

    We will measure the X-rays from kaonic {sup 3}He 3d {yields} 2p transition with a precision below 2 eV. It can provide crucial information on the kaon-nucleus strong interaction. The experiment (J-PARC E17) will be performed as Day-1, which is one of the first experiments in the J-PARC hadron facility in the year 2011. An overview and the present status of the J-PARC E17 experiment are described.

  6. Physics in J-PARC Hadron-Hall Extension

    NASA Astrophysics Data System (ADS)

    Noumi, Hiroyuki

    The Hadron Experimental Facility (HEF) of the Japan Proton Accelerator Research Complex (J-PARC) provides the world highest intensity hadron beams, such as kaons, pions, and so on, for various experimental researches in particle and nuclear physics. Currently, HEF operates two charged and one neutral secondary beam lines, K1.8, K1.1, and KL, sharing secondary beams produced at a primary target, T1. In addition, a high-momentum beam line is being constructed, which is branched from the primary beam line to deliver a fraction of the primary proton beam. We have a plan to extend HEF and construct a several new beam lines, which would enhance physics opportunities at HEF. A floor plan of extended HEF and physics scopes are presented.

  7. Calculation of Accurate Hexagonal Discontinuity Factors for PARCS

    SciTech Connect

    Pounders. J., Bandini, B. R. , Xu, Y, and Downar, T. J.

    2007-11-01

    In this study we derive a methodology for calculating discontinuity factors consistent with the Triangle-based Polynomial Expansion Nodal (TPEN) method implemented in PARCS for hexagonal reactor geometries. The accuracy of coarse-mesh nodal methods is greatly enhanced by permitting flux discontinuities at node boundaries, but the practice of calculating discontinuity factors from infinite-medium (zero-current) single bundle calculations may not be sufficiently accurate for more challenging problems in which there is a large amount of internodal neutron streaming. The authors therefore derive a TPEN-based method for calculating discontinuity factors that are exact with respect to generalized equivalence theory. The method is validated by reproducing the reference solution for a small hexagonal core.

  8. New muonium HFS measurements at J-PARC/MUSE

    NASA Astrophysics Data System (ADS)

    Strasser, P.; Aoki, M.; Fukao, Y.; Higashi, Y.; Higuchi, T.; Iinuma, H.; Ikedo, Y.; Ishida, K.; Ito, T. U.; Iwasaki, M.; Kadono, R.; Kamigaito, O.; Kanda, S.; Kawall, D.; Kawamura, N.; Koda, A.; Kojima, K. M.; Kubo, K.; Matsuda, Y.; Matsudate, Y.; Mibe, T.; Miyake, Y.; Mizutani, T.; Nagamine, K.; Nishimura, S.; Nishiyama, K.; Ogitsu, T.; Okubo, R.; Saito, N.; Sasaki, K.; Seo, S.; Shimomura, K.; Sugano, M.; Tajima, M.; Tanaka, K. S.; Tanaka, T.; Tomono, D.; Torii, H. A.; Torikai, E.; Toyoda, A.; Ueno, K.; Ueno, Y.; Yagi, D.; Yamamoto, A.; Yoshida, M.

    2016-12-01

    At the Muon Science Facility (MUSE) of J-PARC (Japan Proton Accelerator Research Complex), the MuSEUM collaboration is planing new measurements of the ground state hyperfine structure (HFS) of muonium both at zero field and at high magnetic field. The previous measurements were performed both at LAMPF (Los Alamos Meson Physics Facility) with experimental uncertainties mostly dominated by statistical errors. The new high intensity muon beam that will soon be available at MUSE H-Line will provide an opportunity to improve the precision of these measurements by one order of magnitude. An overview of the different aspects of these new muonium HFS measurements, the current status of the preparation, and the results of a first commissioning test experiment at zero field are presented.

  9. Bunch shape monitor development in J-PARC linac

    NASA Astrophysics Data System (ADS)

    Miura, A.; Tamura, J.; Liu, Y.; Miyao, T.

    2017-07-01

    In the linac at the Japan accelerator research complex (J-PARC), we decided to use bunch shape monitors (BSMs) as phase-width monitors. Both centroid-phase set point at the frequency jump from SDTL (324 MHz) to ACS (972 MHz) and phase-width control are key issues for suppressing excess beam loss. BSM was designed and developed at the Institute for Nuclear Research, Russia. Because the BSM was first used between acceleration cavities, we need to improve it to protect it from the leakage-magnetic field of the quadrupole magnets and from outgassing impacts on the cavities. In this paper, we introduce these improvements to the BSM for the adoption of the location nearby the acceleration cavities.

  10. Beam position monitor system of J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Hayashi, N.; Kawase, M.; Hatakeyama, S.; Hiroki, S.; Saeki, R.; Takahashi, H.; Teruyama, Y.; Toyokawa, R.; Arakawa, D.; Hiramatsu, S.; Lee, S.; Satou, K.; Tejima, M.; Toyama, T.

    2012-06-01

    The J-PARC RCS is a 25 Hz Rapid-Cycling proton Synchrotron and its designed beam power is 1 MW. The beam position monitor (BPM) system at J-PARC RCS is described in this paper. The pre-defined diameter of the BPM detectors is larger than 250 mm, however, the system has to measure the beam position very accurately. In addition, it is necessary to have a large dynamic range. The system should work not only for the high intensity but also for low intensity, such as during beam commissioning, when the intensity is below 1% of the design intensity. There are 54 BPM detectors around the ring and most of them are placed inside steering magnets because of quite limited space. The BPM detector is an electro-static type and it has four electrodes, and a pair of electrodes gives a good linear response with a diagonal cut shape to detect the charge center precisely. The signal processing units, which are equipped with 14-bit 40 MS/s ADC and 600 MHz DSP, have been developed. They are accessed via shared memory space and controlled by EPICS. Such a processing unit is capable of recording the full 25 Hz pulse data for the so-called "COD mode" (averaged beam position calculation) and it can also store the whole waveform data for further analysis, like turn-by-turn position calculation. The resolution was estimated to be 20 μm for "COD mode" and to be 0.3 mm for the turn-by-turn mode with relatively low intensity of 8×1011 ppp. The position accuracy is estimated to be about 0.5 mm using a newly developed Beam Based Alignment (BBA) method.

  11. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1994.

    ERIC Educational Resources Information Center

    Mahler, M., Ed.; Haillet, P., Ed.

    1994-01-01

    Contains five articles, all in French, reporting research on French second language instruction. "Francophonie et francais langue seconde a l'oral: quel(s) culture(s), quelles methodes?" (Francophony and Spoken French as a Second Language: What Cultures(s), What Method(s) (D. Issa-Sayegh) discusses the content and structure of a…

  12. RELIEF: Revue de linguistique et d'enseignement du francais (Review of Linguistics and French Language Instruction), 1991-1993.

    ERIC Educational Resources Information Center

    Haillet, P., Ed.; And Others

    1993-01-01

    This document consists of the first two issues of the journal RELIEF. Each issue contains four articles. All articles deal with French second language instruction: (1) "Utiliser la presse ecrite en classe de francais-langue seconde (Using the Print Media in French Second Language Class)" (H. Canto); (2) "Une lecon de grammaire…

  13. Activation of p53-dependent responses in tumor cells treated with a PARC-interacting peptide

    SciTech Connect

    Vitali, Roberta; Cesi, Vincenzo; Tanno, Barbara; Ferrari-Amorotti, Giovanna; Dominici, Carlo; Calabretta, Bruno; Raschella, Giuseppe

    2008-04-04

    We tested the activity of a p53 carboxy-terminal peptide containing the PARC-interacting region in cancer cells with wild type cytoplasmic p53. Peptide delivery was achieved by fusing it to the TAT transduction domain (TAT-p53-C-ter peptide). In a two-hybrid assay, the tetramerization domain (TD) of p53 was necessary and sufficient to bind PARC. The TAT-p53-C-ter peptide disrupted the PARC-p53 complex. Peptide treatment caused p53 nuclear relocation, p53-dependent changes in gene expression and enhancement of etoposide-induced apoptosis. These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.

  14. The Next Generation Muon Source at J-PARC/MLF

    NASA Astrophysics Data System (ADS)

    Nakahara, K.; Adachi, T.; Ikedo, Y.; Miyake, Y.; Shimomura, K.; Strasser, P.; Nishiyama, K.; Kawamura, N.; Fujimori, H.; Makimura, S.; Koda, A.; Nagamine, K.; Ogitsu, T.; Yamamoto, A.; Sasaki, K.; Tanaka, K.; Kimura, N.; Makida, Y.; Ajima, Y.; Ishida, K.; Matsudaf, Y.

    2010-03-01

    The Materials and Life Science Facility (MLF) is currently under construction at J-PARC in Tokai, Japan. The muon section of the facility will house the muon production target and four secondary beam lines used to transport the muons into two experimental halls. Currently, one of the four beam lines (the Decay beam line) has been completed and is operational. The beam line currently under construction is the large acceptance beam line (the so called Super-Omega beam line) which, when completed, will produce the highest intensity pulsed muon beam in the world. The expected rate of surface muons for this beam line is 4×108μ+/s, and a cloud muon rate of 107μ-/s. The beam line consists of the normal-conducting capture solenoids, the superconducting curved transport solenoids, and an axial focusing magnet. The capture solenoids have been fabricated and installed on the beam line, while the transport solenoids are under design, with initial prototype coils under fabrication.

  15. Status of the KOTO experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Beckford, Brian

    2017-01-01

    The K0TO experiment conducted at J-PARC was designed to observe the KL0-->π0 ν ν decay and measure its branching ratio. The current SM prediction for the branching ratio is 3.0 x 10-11 with a small theoretical uncertainty of about 2-3 As a result of the favorable outcome of KEK E391, the K0TO experiment is intended to pursue the search with increased beam power, an upgraded data acquisition system, and improved detector hardware. The signature of the decay is a pair of photons from the π0 decay and no other detected particles. For the measurement of the energies and positions of the photons, K0TO uses a Cesium Iodide (CSI) electromagnetic calorimeter as the main detector, and hermetic veto counters to guarantee that there are no other detected particles. The initial data was collected in 2013, followed by additional runs in 2015-2016 at beam powers of 24 and 40 kW, respectively. In this talk, we present a description of the upgrades and improvements to the detector, present status, and the latest results. For the K0TO collaboration.

  16. Development of engineering diffractometer at J-PARC

    NASA Astrophysics Data System (ADS)

    Moriai, Atsushi; Torii, Shuki; Suzuki, Hiroshi; Harjo, Stefanus; Morii, Yukio; Arai, Masatoshi; Tomota, Yo; Suzuki, Tetsuya; Akiniwa, Yoshiaki; Kimura, Hidehiko; Akita, Koich

    2006-11-01

    An engineering diffractometer for investigations of stresses and crystallographic structures within engineering components is now being developed at J-PARC project. The diffractometer is designed to view a decoupled-poisoned liquid H 2 moderator providing neutrons with good symmetrical diffraction profiles in the acceptable wavelength range. The diffractometer will have a primary flight path of 40 m and a secondary flight path of 2.0 m for 90° scattering detector banks, and will include a curved supermirror neutron guide to avoid intensity loss due to the long flight path and to reduce backgrounds from fast neutrons and gamma rays. Therefore, stresses with sufficient accuracies in many engineering studies are quite promising. The diffractometer involves a sample translator which is able to handle large and heavy real industrial-scaled components. Detailed design works are being continuously promoted. The optimization of the diffractometer has been performed with a Monte Carlo simulation, and an appropriate resolution of less than 0.2% in Δ d/ d has been confirmed.

  17. Current status of the J-PARC muon facility, MUSE

    NASA Astrophysics Data System (ADS)

    Miyake, Y.; Shimomura, K.; Kawamura, N.; Strasser, P.; Koda, A.; Fujimori, H.; Ikedo, Y.; Makimura, S.; Kobayashi, Y.; Nakamura, J.; Kojima, K.; Adachi, T.; Kadono, R.; Takeshita, S.; Nishiyama, K.; Higemoto, W.; Ito, T.; Nagamine, K.; Ohata, H.; Makida, Y.; Yoshida, M.; Okamura, T.; Okada, R.; Ogitsu, T.

    2014-12-01

    The muon science facility (MUSE), along with the neutron, hadron, and neutrino facilities, is one of the experimental areas of the J-PARC project. The MUSE facility is located in the Materials and Life Science Facility (MLF), which is a building integrated to include both neutron and muon science programs. Since the autumn of 2008, users operation is effective and making use of the pulsed muon beam particularly at the D-Line. Unfortunately, MUSE suffered severe damages from the earthquake on March 11, 2011, the so-called "Higashi-Nippon Dai-Shinsai". We managed to have a stable operation of the superconducting solenoid magnet with use of the on-line refrigerator on December, 2012, although we had to overcome a lot of difficulties against components not working properly. But we had to stop again the whole operations on May 2013, because of the radioactive materials leakage accident at the Hadron Hall Experimental Facility. Finally we restarted the users' runs on February 2014.

  18. A Design for Living: The PARC Plan. Report of the PARC Ad Hoc Planning Committee for Resolution II, October 19, 1974.

    ERIC Educational Resources Information Center

    Pennsylvania Association for Retarded Citizens, Harrisburg.

    Presented is the PARC (Pennsylvania Association for Retarded Citizens) Plan which resulted from a 3-month survey of Pennsylvania's institutional system and which was designed to improve living conditions and programs of state schools and hospitals serving the mentally retarded. Detailed are specific recommendations for the achievement of annual…

  19. Cryogenic system for COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Ki, Taekyung; Yoshida, Makoto; Yang, Ye; Ogitsu, Toru; Iio, Masami; Makida, Yasuhiro; Okamura, Takahiro; Mihara, Satoshi; Nakamoto, Tatsushi; Sugano, Michinaka; Sasaki, Ken-ichi

    2016-07-01

    Superconducting conductors and cryogenic refrigeration are key factors in the accelerator science because they enable the production of magnets needed to control and detect the particles under study. In Japan, a system for COMET (Coherent Muon to Electron Transition), which will produce muon beam lines, is under the construction at J-PARC (Japan Proton Accelerator Research Complex). The system consists of three superconducting magnets; the first is a pion-capture solenoid, the second is a muon-transport solenoid, and the third is a detector solenoid. It is necessary to cool down the magnets efficiently using two-phase helium and maintain them securely at 4.5 K. For stable cryogenic refrigeration of the magnets, a suitable cooling method, structures, and the irradiation effect on materials should be investigated. In this paper, we focus on the development of an overall cryogenic system for cooling the capture and transport solenoids. A conduction-cooling method is considered for cooling the capture and transport solenoids because of the advantages such as the reduction of total heat load, fewer components, and simplified structure. To supply cryogenic fluids (4.5 K liquid helium and 58 K gas helium) and currents to the conduction-cooled magnets subjected to high irradiation, cryogenic components (cooling paths in the magnets, transfer tubes, and a current lead box) are developed. Based on the environment of high irradiation, the conditions (temperature and pressure) of helium in cooling paths are estimated, as well as the temperature of the capture magnet. We develop a dynamic model for quench simulation and estimate the maximum pressure in the cooling pipe when the capture magnet quenches. We conclude with a discussion of the next steps and estimated challenges for the cryogenic system.

  20. PARC Navier-Stokes code upgrade and validation for high speed aeroheating predictions

    NASA Technical Reports Server (NTRS)

    Liver, Peter A.; Praharaj, Sarat C.; Seaford, C. Mark

    1990-01-01

    Applications of the PARC full Navier-Stokes code for hypersonic flowfield and aeroheating predictions around blunt bodies such as the Aeroassist Flight Experiment (AFE) and Aeroassisted Orbital Transfer Vehicle (AOTV) are evaluated. Two-dimensional/axisymmetric and three-dimensional perfect gas versions of the code were upgraded and tested against benchmark wind tunnel cases of hemisphere-cylinder, three-dimensional AFE forebody, and axisymmetric AFE and AOTV aerobrake/wake flowfields. PARC calculations are in good agreement with experimental data and results of similar computer codes. Difficulties encountered in flowfield and heat transfer predictions due to effects of grid density, boundary conditions such as singular stagnation line axis and artificial dissipation terms are presented together with subsequent improvements made to the code. The experience gained with the perfect gas code is being currently utilized in applications of an equilibrium air real gas PARC version developed at REMTECH.

  1. PARC Navier-Stokes code upgrade and validation for high speed aeroheating predictions

    NASA Technical Reports Server (NTRS)

    Liver, Peter A.; Praharaj, Sarat C.; Seaford, C. Mark

    1990-01-01

    Applications of the PARC full Navier-Stokes code for hypersonic flowfield and aeroheating predictions around blunt bodies such as the Aeroassist Flight Experiment (AFE) and Aeroassisted Orbital Transfer Vehicle (AOTV) are evaluated. Two-dimensional/axisymmetric and three-dimensional perfect gas versions of the code were upgraded and tested against benchmark wind tunnel cases of hemisphere-cylinder, three-dimensional AFE forebody, and axisymmetric AFE and AOTV aerobrake/wake flowfields. PARC calculations are in good agreement with experimental data and results of similar computer codes. Difficulties encountered in flowfield and heat transfer predictions due to effects of grid density, boundary conditions such as singular stagnation line axis and artificial dissipation terms are presented together with subsequent improvements made to the code. The experience gained with the perfect gas code is being currently utilized in applications of an equilibrium air real gas PARC version developed at REMTECH.

  2. Science Goals of the Primary Atomic Reference Clock in Space (PARCS) Experiment

    NASA Technical Reports Server (NTRS)

    Ashby, N.

    2003-01-01

    The PARCS (Primary Atomic Reference Clock in Space) experiment will use a laser-cooled Cesium atomic clock operating in the microgravity environment aboard the International Space Station (ISS) to provide both advanced tests of gravitational theory and to demonstrate a new cold-atom clock technology for space. PARCS is a joint project of the National Institute of Standards and Technology (NIST), NASA's Jet Propulsion Laboratory (JPL), and the University of Colorado (CU). This paper concentrates on the scientific goals of the PARCS mission. The microgravity space environment allows laser-cooled Cs atoms to have Ramsey times in excess of those feasible on Earth, resulting in improved clock performance. Clock stabilities of 5x10(exp -14) at one second, and accuracies better than 10(exp -16) are projected.

  3. Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli.

    PubMed Central

    Vila, J; Ruiz, J; Goñi, P; De Anta, M T

    1996-01-01

    The gene parC encodes the A subunit of topoisomerase IV of Escherichia coli. Mutations in the parC region analogous to those in the quinolone resistance-determining region of gyrA were investigated in 27 clinical isolates of E. coli for which ciprofloxacin MICs were 0.0007 to 128 micrograms/ml. Of 15 isolates for which ciprofloxacin MICs were > or = 1 microgram/ml, 8 showed a change in the serine residue at position 80 (Ser-80), 4 showed a change in Glu-84, and 3 showed changes in both amino acids. No mutations were detected in 12 clinical isolates for which ciprofloxacin MICs were < or = 0.25 micrograms/ml. These findings suggest that ParC from E. coli may be another target for quinolones and that mutations at residues Ser-80 and Glu-84 may contribute to decreased fluoroquinolone susceptibility. PMID:8834907

  4. Searching for Sterile Neutrinos at J-PARC with JSNS2

    NASA Astrophysics Data System (ADS)

    Jordan, Johnathon; JSNS2 Collaboration

    2017-01-01

    The J-PARC Sterile Neutrino Search at the J-PARC Spallation Neutron Source (JSNS2) will look for neutrino oscillations with a characteristic frequency of Δm2 1 eV2. The experiment will be constructed at the J-PARC Material and Life Science Experimental Facility (MLF) and will perform a search for νμ ->νe oscillations over a 24 m baseline using muon decay at rest neutrinos originating from 3 GeV proton interactions with a mercury target. Using two tanks of Gd-doped liquid scintillator with a total fiducial volume of 50 tons, JSNS2 will exploit the unique signature of inverse beta decay (prompt positron signal, delayed gammas from neutron capture) to look for νe appearance. Additionally, JSNS2 will enable novel cross section measurements using 236 MeV muon neutrinos from charged kaon decay at rest (KDAR).

  5. Measurement of neutron capture cross section of Li-7 at J-PARC / MLF / ANNRI

    SciTech Connect

    Makii, H.; Ota, S.; Nishinaka, I.; Nishio, I.; Segawa, M.; Kimura, A.; Harada, H.

    2014-05-02

    We have measured the {sup 7}Li(n,γ){sup 8}Li reaction at Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) installed at the Material and Life science experimental Facility in the Japan Proton Accelerator Research Complex (J-PARC / MLF). In this experiment, we used intense pulsed neutron beam provided by J-PARC / MLF and high performance Ge spectrometer, which is one of the main detectors of the ANNRI. We clearly detected γ rays from the {sup 7}Li(n,γ){sup 8}Li reaction with sufficient signal-to-noise ratio.

  6. Precision Spectroscopy of Kaonic Helium-3 X-rays at J-PARC

    SciTech Connect

    Hashimoto, T.; Fujiwara, Y.; Hayano, R. S.; Ishikawa, T.; Sato, M.; Shi, H.; Suzuki, T.; Tatsuno, H.; Bhang, H.; Choi, Seonho; Tanida, K.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Widmann, E.; Wuenschek, B. K.; Zmeskal, J.; Curceanu, C.; Guaraldo, C.; Okada, S.

    2011-10-21

    We will measure the x-rays from kaonic {sup 3}He and {sup 4}He 3d{yields}2p transition by using silicon drift detectors. Our precision goal is set to 1 eV to provide crucial information on the kaon-nucleus strong interaction in the low energy limit. The experiment is to be performed as one of the first experiment in the J-PARC hadron facility (J-PARC E17). An overview and the present status of the experiment are presented.

  7. Drug efflux and parC mutations are involved in fluoroquinolone resistance in viridans group streptococci.

    PubMed

    Ferrándiz, M J; Oteo, J; Aracil, B; Gómez-Garcés, J L; De La Campa, A G

    1999-10-01

    Nine ciprofloxacin-resistant viridans group streptococci isolated from asymptomatic carriers were analyzed. Identification to the species level by using three different commercial systems and a PCR-based approach was inconsistent. The nucleotide sequences of fragments of the parC, parE, gyrA, and gyrB genes showed considerable intra- and interspecies variations, and these variations mainly involved silent mutations. Three isolates had changes in Ser-79 of ParC (to Phe or Tyr). Phenotypic characterization indicated that eight of the nine isolates had a putative efflux mechanism that would confer low-level resistance to ciprofloxacin.

  8. Drug Efflux and parC Mutations Are Involved in Fluoroquinolone Resistance in Viridans Group Streptococci

    PubMed Central

    Ferrándiz, María José; Oteo, Jesús; Aracil, Belén; Gómez-Garcés, Jose Luis; De La Campa, Adela G.

    1999-01-01

    Nine ciprofloxacin-resistant viridans group streptococci isolated from asymptomatic carriers were analyzed. Identification to the species level by using three different commercial systems and a PCR-based approach was inconsistent. The nucleotide sequences of fragments of the parC, parE, gyrA, and gyrB genes showed considerable intra- and interspecies variations, and these variations mainly involved silent mutations. Three isolates had changes in Ser-79 of ParC (to Phe or Tyr). Phenotypic characterization indicated that eight of the nine isolates had a putative efflux mechanism that would confer low-level resistance to ciprofloxacin. PMID:10508036

  9. TRACE/PARCS Core Modeling of a BWR/5 for Accident Analysis of ATWS Events

    SciTech Connect

    Cuadra A.; Baek J.; Cheng, L.; Aronson, A.; Diamond, D.; Yarsky, P.

    2013-11-10

    The TRACE/PARCS computational package [1, 2] isdesigned to be applicable to the analysis of light water reactor operational transients and accidents where the coupling between the neutron kinetics (PARCS) and the thermal-hydraulics and thermal-mechanics (TRACE) is important. TRACE/PARCS has been assessed for itsapplicability to anticipated transients without scram(ATWS) [3]. The challenge, addressed in this study, is to develop a sufficiently rigorous input model that would be acceptable for use in ATWS analysis. Two types of ATWS events were of interest, a turbine trip and a closure of main steam isolation valves (MSIVs). In the first type, initiated by turbine trip, the concern is that the core will become unstable and large power oscillations will occur. In the second type,initiated by MSIV closure,, the concern is the amount of energy being placed into containment and the resulting emergency depressurization. Two separate TRACE/PARCS models of a BWR/5 were developed to analyze these ATWS events at MELLLA+ (maximum extended load line limit plus)operating conditions. One model [4] was used for analysis of ATWS events leading to instability (ATWS-I);the other [5] for ATWS events leading to emergency depressurization (ATWS-ED). Both models included a large portion of the nuclear steam supply system and controls, and a detailed core model, presented henceforth.

  10. Measurement of the neutron capture cross section of 99Tc using ANNRI at J-PARC

    NASA Astrophysics Data System (ADS)

    Katabuchi, Tatsuya; Mizumoto, Motoharu; Igashira, Masayuki; Terada, Kazushi; Kimura, Atsushi; Nakamura, Shoji; Nakao, Taro; Iwamoto, Osamu; Iwamoto, Nobuyuki; Mizuyama, Kazuhito; Harada, Hideo; Hori, Jun-ich; Kino, Koichi

    2017-09-01

    The neutron capture cross section of 99Tc was measured using NaI(Tl) detectors of the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) at the Japan Proton Accelerator Research Complex (J-PARC) in the energy range from thermal to the keV energy region. Preliminary results were presented and compared with previous measurements and evaluations.

  11. Construction of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    SciTech Connect

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Ajima, Y.; Araoka, O.; Fujii, Y.; Hastings, N.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Okamura, T.; Sakashita, K.; Sugawara, S.; Suzuki, S.; Tanaka, K.; Tomaru, T.; Terashima, A.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; gupta, R.; Jain, A.; Muratore, J.; Parker, B.; Boussuge, T.; Charrier, J.-P.; Arakawa, M.; Ichihara, T.; Minato, T.; Okada, Y.; Itou, A.; Kumaki, T.; Nagami, M.; Takahashi, T.

    2009-10-18

    Following success of a prototype R&D, construction of a superconducting magnet system for J-PARC neutrino beam line has been carried out since 2005. A new conceptual beam line with the superconducting combined function magnets demonstrated the successful beam transport to the neutrino production target.

  12. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran.

    PubMed

    Nouri, Roghayeh; Ahangarzadeh Rezaee, Mohammad; Hasani, Alka; Aghazadeh, Mohammad; Asgharzadeh, Mohammad

    The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR) of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs) of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75%) of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates. Copyright © 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

  13. The LEM Experiment:. Measurement of Low Energy Spectrum at J-PARC On-Axis Neutrino Beam

    NASA Astrophysics Data System (ADS)

    Kaji, H.

    2013-03-01

    The LEM experiment measures the flux of J-PARC neutrino beam. We newly constructed the neutrino monitor, LEM, and installed at the J-PARC ND280 hall. We measure neutrino flux in the low energy part of on-axis direction. This part of the neutrino beam cannot be measured by any of T2K detectors. Therefore we can help further understandings of the J-PARC neutrino flux. The detailed design of detector is shown. In addition, the status of construction and installation at the ND280 hall is reported.

  14. Operational Experiences of J-PARC cryogenic hydrogen system for a spallation neutron source

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Aso, T.; Ohtsu, K.; Kawakami, Y.; Aoyagi, K.; Muto, H.

    2015-12-01

    The Japan Proton Accelerator Research Complex (J-PARC) cryogenic hydrogen system was completed in April 2008. The proton beam power was gradually increased to 500 kW. A trial 600-kW proton beam operation was successfully completed in April 2015. We achieved long-lasting operation for more than three months. However, thus far, we encountered several problems such as unstable operation of the helium refrigerator because of some impurities, failure of a welded bellows of an accumulator, and hydrogen pump issues. Furthermore, the Great East Japan Earthquake was experienced during the cryogenic hydrogen system operation in March 2011. In this study, we describe the operation characteristics and our experiences with the J-PARC cryogenic hydrogen system.

  15. Neutron capture cross section measurements at the beam line 04 of J-PARC/MLF

    SciTech Connect

    Igashira, Masayuki; Harada, Hideo; Kiyanagi, Yoshiaki

    2012-11-12

    An Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI) at the beam line 04 of MLF (Material and Life Sciences Experimental Facilities) of J-PARC (Japan Proton Accelerator Research Complex) was installed to measure neutron capture cross sections related to the research and development of innovative nuclear systems, the study on nuclear astrophysics, etc. ANNRI has two gamma-ray spectrometers: one is a Ge detector array placed at 22 m from the coupled type moderator of the spallation neutron source of J-PARC/MLF and the other is a pair of NaI(Tl) detectors at 28 m. Until the 11th of March, 2011, when we had big earthquakes, we measured capture cross sections of Zr-93, Tc-99, Pd-107, I-129, Cm-244, Cm-246, etc. After checking and repairing ANNRI, we restarted measurements, and ANNRI has been open to worldwide users at present.

  16. Code Development in Coupled PARCS/RELAP5 for Supercritical Water Reactor

    DOE PAGES

    Hu, Po; Wilson, Paul

    2014-01-01

    The new capability is added to the existing coupled code package PARCS/RELAP5, in order to analyze SCWR design under supercritical pressure with the separated water coolant and moderator channels. This expansion is carried out on both codes. In PARCS, modification is focused on extending the water property tables to supercritical pressure, modifying the variable mapping input file and related code module for processing thermal-hydraulic information from separated coolant/moderator channels, and modifying neutronics feedback module to deal with the separated coolant/moderator channels. In RELAP5, modification is focused on incorporating more accurate water properties near SCWR operation/transient pressure and temperature in themore » code. Confirming tests of the modifications is presented and the major analyzing results from the extended codes package are summarized.« less

  17. Status of Superconducting Magnet System for the J-PARC Neutrino Beam Line

    SciTech Connect

    Nakamoto, T.; Wanderer, P.; Sasaki, K.; Araoka, O.; Fugii, Y.; Higashi, N.; Iida, M.; Ishii, T.; Kimura, N.; Kobayashi, T.; Makida, Y.; Nakadaira, T.; Ogitsu, T.; Ohhata, H.; Olamura, T.; Sakashita, K.; Shibata, M.; Suzuki, S.; Yamamoto, A.; Ichikawa, A.; Kakuno, H.; Anerella, M.; Escallier, J.; Ganetis, G.; Ghosh, A.; Muratore, J.; Parker, B.; Wanderer, P.

    2011-08-03

    The superconducting magnet system for the J-PARC neutrino beam line for the T2K experiment has been served for the beam operation without serious disturbance since April 2009. Present most concern of the system is the operational current limit of superconducting corrector magnets for beam steering due to systematic quenches at lower currents. Operational experience of the magnet system and examples of troubleshoot including countermeasures against the corrector magnet quenches are presented.

  18. The Application of DAQ-Middleware to the J-PARC E16 Experiment

    NASA Astrophysics Data System (ADS)

    Hamada, E.; Ikeno, M.; Kawama, D.; Morino, Y.; Nakai, W.; Obara, Y.; Ozawa, K.; Sendai, H.; Takahashi, T. N.; Tanaka, M. M.; Yokkaichi, S.

    2015-12-01

    DAQ-Middleware is a software framework for network-distributed data acquisition (DAQ) systems. We adopted the framework for the J-PARC E16 experiment, which requires a DAQ bandwidth of more than 660 MB/spill (two-second spill per six-second cycle). We developed a prototype for the DAQ software and confirmed that the prototype's total throughput satisfies the requirements of the experiment.

  19. Calpain-mediated Processing of p53-associated Parkin-like Cytoplasmic Protein (PARC) Affects Chemosensitivity of Human Ovarian Cancer Cells by Promoting p53 Subcellular Trafficking*

    PubMed Central

    Woo, Michael G.; Xue, Kai; Liu, Jiayin; McBride, Heidi; Tsang, Benjamin K.

    2012-01-01

    Resistance to cisplatin (CDDP)-based therapy is a major hurdle to the successful treatment of human ovarian cancer (OVCA), and the chemoresistant phenotype in OVCA cells is associated with Akt-attenuated p53-mediated apoptosis. Pro-apoptotic functions of p53 involve both transcription-dependent and -independent signaling pathways, and dysfunctional localization and/or inactivation of p53 contribute to the development of chemoresistance. PARC is a cytoplasmic protein regulating p53 subcellular localization and subsequent function. Little is known about the molecular mechanisms regulating PARC. Although PARC contains putative caspase-3 cleavage sites, and CDDP is known to induce the activation of caspases and calpains and induce proteasomal degradation of anti-apoptotic proteins, if and how PARC is regulated by CDDP in OVCA are unknown. Here, we present evidence that CDDP promotes calpain-mediated PARC down-regulation, mitochondrial and nuclear p53 accumulation, and apoptosis in chemosensitive but not resistant OVCA cells. Inhibition of Akt is required to sensitize chemoresistant cells to CDDP in a p53-dependent manner, an effect enhanced by PARC down-regulation. CDDP-induced PARC down-regulation is reversible by inhibition of calpain but not of caspases or the 26 S proteasome. Furthermore, in vitro experiments confirm the ability of calpain in mediating Ca2+-dependent PARC down-regulation. The role of Ca2+ in PARC down-regulation was further confirmed as ionomycin-induced PARC down-regulation in both chemosensitive and chemoresistant ovarian cancer cells. The data presented here implicate the regulation of p53 subcellular localization and apoptosis by PARC as a contributing factor in CDDP resistance in OVCA cells and Ca2+/calpain in PARC post-translational processing and chemosensitivity. PMID:22117079

  20. Auto-tuning systems for J-PARC LINAC RF cavities

    NASA Astrophysics Data System (ADS)

    Fang, Z.; Kobayashi, T.; Fukui, Y.; Futatsukawa, K.; Michizono, S.; Yamaguchi, S.; Anami, S.; Suzuki, H.; Sato, F.; Shinozaki, S.; Chishiro, E.

    2014-12-01

    The 400-MeV proton linear accelerator (LINAC) at the Japan Proton Accelerator Research Complex (J-PARC) consists of 324-MHz low-β and 972-MHz high-β accelerator sections. From October 2006 to May 2013, only the 324-MHz low-β accelerator section was in operation. From the summer of 2013 the J-PARC LINAC was upgraded by installing the 972-MHz high-β accelerator section, and the proton beam was successfully accelerated to 400 MeV in January 2014. Auto-tuning systems for the J-PARC LINAC RF cavities have been successfully developed. A first generation design, an auto-tuning system using a mechanical tuner controller, was developed and operated for the first 3 years. Then the second-generation auto-tuning system was developed using a new approach to the RF cavity warm-up process, and this was applied to the accelerator operation for the subsequent 4 years. During the RF cavity warm-up process in this system, the mechanical tuner is constantly fixed and the input RF frequency is automatically tuned to the cavity resonance frequency using the FPGA (Field-Programmable Gate Array) of the digital feedback RF control system. After the input power level reaches the required value, input RF frequency tuning is stopped and it is switched to the operation frequency. Then, the mechanical tuner control begins operation. This second-generation auto-tuning system was extremely effective for the 324-MHz cavity operation. However, if we apply this approach to the 972-MHz RF cavities, an interlock due to the RF cavity reflection amplitude occasionally occurs at the end of the warm-up process. In order to solve this problem a third generation novel auto-tuning system was successfully developed in December 2013 and applied to the operation of the J-PARC LINAC, including the 972-MHz ACS RF cavities. During the warm-up process both the mechanical tuner controller and the input RF frequency tuning are in operation, and good matching between the input RF frequency and the RF cavity is

  1. D'une ouverture de la voyelle /epsilon/ en finale absolue en francais quebecois : analyse acoustique et perceptive

    NASA Astrophysics Data System (ADS)

    Riverin-Coutlee, Josiane

    Cette contribution est consacree a l'ouverture du /epsilon/ en finale absolue, un phenomene phonetique repute etre en declin en francais quebecois et caracteristique de locuteurs âges, peu scolarises, issus de milieux populaires et s'exprimant en situation de communication informelle. Une analyse acoustique de 480 voyelles /epsilon/ issues de la parole formelle de 40 jeunes etudiants universitaires originaires des centres urbains de Saguenay et de Quebec revele toutefois que le phenomene est encore bien vivant en francais quebecois et qu'il est plus frequent chez les locuteurs de Saguenay, une tendance validee auditivement par accord inter-juges. Les resultats d'un test de discrimination et d'identification mene aupres de 26 etudiants universitaires originaires de ces deux memes villes indiquent que les auditeurs naifs de Saguenay semblent moins sensibles a la variation et moins enclins a juger de l'origine geographique d'un locuteur a partir de sa prononciation de la voyelle /epsilon/ en fin de mot.

  2. L'enseignement du francais en Republique Federale d'Allemagne (The Teaching of French in the Federal Republic of Germany). L'enseignement du francais dans les classes terminales des lycees allemands (The Teaching of French in the Final Year in German Schools).

    ERIC Educational Resources Information Center

    Abel, Fritz; Lang, Jurgen

    Two papers describe two aspects of French foreign language instruction in West Germany. The first, "L'enseignement du francais en Republique Federale d'Allemagne" by Abel, deals with the institutional framework for French instruction in West Germany. A discussion of the instructional situation looks first at the history of French…

  3. L'enseignement modulaire et le laboratoire de langues: conception et experimentation d'un nouveau cours de francais oral au Centre d'anglais et de francais, Universite McGill (Modular Instruction and the Language Laboratory: Conception and Experimentation with a New Course in Oral French at the English and French Center, McGill University).

    ERIC Educational Resources Information Center

    Legoux, Marie-Noelle

    1980-01-01

    A modular-type course in French was developed at the "Centre d'anglais et de francais" at McGill University (Montreal) to meet the needs of incoming students who were lacking skills in listening and oral expression. The course is composed of eight modules a semester, each module corresponding to 15 to 20 hours work on the student's part. The…

  4. Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly1[OPEN

    PubMed Central

    Chen, Cheng; Froehlich, John E.; TerBush, Allan D.

    2016-01-01

    Chloroplast division is driven by the simultaneous constriction of the inner FtsZ ring (Z ring) and the outer DRP5B ring. The assembly and constriction of these rings in Arabidopsis (Arabidopsis thaliana) are coordinated partly through the inner envelope membrane protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS6 (ARC6). Previously, we showed that PARC6 (PARALOG OF ARC6), also in the inner envelope membrane, negatively regulates FtsZ assembly and acts downstream of ARC6 to position the outer envelope membrane protein PLASTID DIVISION1 (PDV1), which functions together with its paralog PDV2 to recruit DYNAMIN-RELATED PROTEIN 5B (DRP5B) from a cytosolic pool to the outer envelope membrane. However, whether PARC6, like ARC6, also functions in coordination of the chloroplast division contractile complexes was unknown. Here, we report a detailed topological analysis of Arabidopsis PARC6, which shows that PARC6 has a single transmembrane domain and a topology resembling that of ARC6. The newly identified stromal region of PARC6 interacts not only with ARC3, a direct inhibitor of Z-ring assembly, but also with the Z-ring protein FtsZ2. Overexpression of PARC6 inhibits FtsZ assembly in Arabidopsis but not in a heterologous yeast system (Schizosaccharomyces pombe), suggesting that the negative regulation of FtsZ assembly by PARC6 is a consequence of its interaction with ARC3. A conserved carboxyl-terminal peptide in FtsZ2 mediates FtsZ2 interaction with both PARC6 and ARC6. Consistent with its role in the positioning of PDV1, the intermembrane space regions of PARC6 and PDV1 interact. These findings provide new insights into the functions of PARC6 and suggest that PARC6 coordinates the inner Z ring and outer DRP5B ring through interaction with FtsZ2 and PDV1 during chloroplast division. PMID:26527658

  5. Association between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance

    PubMed Central

    Ardebili, Abdollah; Lari, Abdolaziz Rastegar; Beheshti, Maryam; Lari, Elnaz Rastegar

    2015-01-01

    Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyrA and parC genes. Results: The 44 and 4 isolates of A. baumannii exhibited full and intermediate-resistant to ciprofloxacin, respectively. Overall, the 42 isolates with double mutations of gyrA and parC genes showed a higher level of ciprofloxacin resistance than the 3 isolates with single mutations of gyrA or parC. Conclusion: Simultaneous mutations in gyrA and parC genes are expected to play a major role in high-level fluoroquinolone resistance in A. baumannii; albeit a single mutation in DNA topoisomerase IV could occasionally be associated with intermediate-resistance to these antimicrobials. PMID:26221488

  6. Characterization of a point mutation in the parC gene of Mycoplasma bovirhinis associated with fluoroquinolone resistance.

    PubMed

    Hirose, K; Kawasaki, Y; Kotani, K; Abiko, K; Sato, H

    2004-05-01

    Quinolone-resistant (QR) mutants of Mycoplasma bovirhinis strain PG43 (type strain) were generated by stepwise selection in increasing concentrations of enrofloxacin (ENR). An alteration was found in the quinolone resistance-determining region (QRDR) of the parC gene coding for the ParC subunit of topoisomerase IV from these mutants, but not in the gyrA, gyrB, and parE gene coding for the GyrA and GyrB subunits of DNA gyrase and the ParE subunit of topoisomerase IV. Similarly, such an alteration in QRDR of parC was found in the field isolates of M. bovirhinis, which possessed various levels of QR. The substitution of leucine (Leu) by serine (Ser) at position 80 of QRDR of ParC was observed in both QR-mutants and QR-isolates. This is the first report of QR based on a point mutation of the parC gene in M. bovirhinis.

  7. Rod-filter-field optimization of the J-PARC RF-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Ueno, A.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-01

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second-stage requirements of an H- ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H- ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). Although rod-filter-field (RFF) is indispensable and one of the most beam performance dominative parameters for the RF-driven H- ion source with the internal-antenna, the procedure to optimize it is not established. In order to optimize the RFF and establish the procedure, the beam performances of the J-PARC source with various types of rod-filter-magnets (RFMs) were measured. By changing RFM's gap length and gap number inside of the region projecting the antenna inner-diameter along the beam axis, the dependence of the H- ion beam intensity on the net 2MHz-RF power was optimized. Furthermore, the fine-tuning of RFM's cross-section (magnetmotive force) was indispensable for easy operation with the temperature (TPE) of the plasma electrode (PE) lower than 70°C, which minimizes the transverse emittances. The 5% reduction of RFM's cross-section decreased the time-constant to recover the cesium effects after an slightly excessive cesiation on the PE from several 10 minutes to several minutes for TPE around 60°C.

  8. Application of a generalized interface module to the coupling of PARCS with both RELAP5 and TRAC-M

    SciTech Connect

    Barber, D.A.; Wang, W.; Miller, R.M.; Downar, T.J.; Joo, H.G.; Mousseau, V.A.; Ebert, D.E.

    1999-04-01

    In an effort to more easily assess various combinations of 3-D neutronic/thermal-hydraulic codes, the USNRC has sponsored the development of a generalized interface module for the coupling of any thermal-hydraulics code to any spatial kinetics code. In this design, the thermal-hydraulics, general interface, and spatial kinetics codes function independently and utilize the Parallel Virtual Machine (PVM) software to manage inter-process communication. Using this interface, the USNRC version of the 3D neutron kinetics code, PARCS, has been coupled to the USNRC system analysis codes RELAP5 and TRAC-M. RELAP5/PARCS assessment results are presented for an OECD/NEA main steam line break benchmark problem. The assessment of TRAC-M/PARCS has only recently been initiated; nonetheless, the capabilities of the coupled code are presented for the OECD/NEA main steam line break benchmark problem.

  9. Quantum-gravity decoherence effects in neutrino oscillations: Expected constraints from CNGS and J-PARC

    SciTech Connect

    Mavromatos, Nick E.; Sarkar, Sarben; Meregaglia, Anselmo; Sakharov, Alexander S.

    2008-03-01

    Quantum decoherence, the evolution of pure states into mixed states, may be a feature of quantum-gravity models. In most cases, such models lead to fewer neutrinos of all active flavors being detected in a long-baseline experiment as compared to three-flavor standard neutrino oscillations. We discuss the potential of the CNGS and J-PARC beams in constraining models of quantum-gravity induced decoherence using neutrino oscillations as a probe. We use as much as possible model-independent parametrizations, even though they are motivated by specific microscopic models, for fits to the expected experimental data which yield bounds on quantum-gravity decoherence parameters.

  10. Prototype of network distributed control system for MLF/J-PARC

    NASA Astrophysics Data System (ADS)

    Nakatani, Takeshi; Nakajima, Kenji; Torii, Shuki; Bharoto; Higemoto, Wataru; Sato, Setsuo; Otomo, Toshiya; Arai, Masatoshi

    2006-11-01

    We have developed a prototype data acquisition and device control system for experiment instruments at the Material and Life science Facility (MLF)/Japan-Proton Accelerator Research Complex (J-PARC). The system employs distributed computing via Ethernet, client/server architecture, modular structure and a state machine. Communication between client and server software utilizes socket protocols over TCP/IP. We have deployed this prototype software in the network distributed control system by improving the data acquisition software used at KENS, introducing the system for the SWAN at KENS/KEK. It was kept in working order throughout 2 weeks of machine operation.

  11. A search for deeply bound kaonic nuclear states at J-PARC

    SciTech Connect

    Hiraiwa, T.; Fujioka, H.; Nagae, T.; Sada, Y.; Ajimura, S.; Noumi, H.; Beer, G.; Bhang, H.; Choi, S.; Yim, H.; Bragadirenn, M.; Sirghi, D.; Sirghi, F.; Buehler, P.; Cargnelli, M.; Ishiwatari, T.; Marton, J.; Suzuki, K.; Widmann, E.; Zmeskal, J.

    2010-08-05

    J-PARC E15 experiment aims to search for the lightest kaonic nuclei, namely K{sup -}pp bound states, using in-flight (K{sup -}, n) reactions. The advantage of this experiment is to perform exclusive measurement by missing mass study using the primary neutrons and invariant mass spectroscopy via such decay as K{sup -}pp{yields}{Lambda}p{yields}p{pi}{sup -}p, simultaneously. In this report, an overview of this experiment and the current status are presented.

  12. Primary proton beam line at the J-PARC hadron experimental facility

    NASA Astrophysics Data System (ADS)

    Agari, Keizo; Hirose, Erina; Ieiri, Masaharu; Iio, Masami; Katoh, Yoji; Kiyomichi, Akio; Minakawa, Michifumi; Muto, Ryotaro; Naruki, Megumi; Noumi, Hiroyuki; Sato, Yoshinori; Sawada, Shin'ya; Shirakabe, Yoshihisa; Suzuki, Yoshihiro; Takahashi, Hitoshi; Takasaki, Minoru; Tanaka, Kazuhiro H.; Toyoda, Akihisa; Watanabe, Hiroaki; Yamanoi, Yutaka

    2012-10-01

    A brief description of the primary beam line at the hadron experimental facility at the Japan Proton Accelerator Research Complex (J-PARC) is presented. The facility has been constructed in Tokai, Japan, and the first beam was successfully introduced into the experimental hall in January 2009. The facility utilizes a high-intensity proton beam with an energy of 50 GeV and a power of 750 kW and provides various secondary beams such as pions, kaons, and antiprotons for nuclear and particle physics experiments. We have developed beam-line components with sufficient radiation hardness and heat resistance to handle the high-power proton beam.

  13. Design and construction of the ultra-slow muon beamline at J-PARC/MUSE

    NASA Astrophysics Data System (ADS)

    Strasser, P.; Ikedo, Y.; Makimura, S.; Nakamura, J.; Nishiyama, K.; Shimomura, K.; Fujimori, H.; Adachi, T.; Koda, A.; Kawamura, N.; Kobayashi, Y.; Higemoto, W.; Ito, T. U.; Nagatomo, T.; Torikai, E.; Kadono, R.; Miyake, Y.

    2014-12-01

    At the J-PARC Muon Science Facility (MUSE), a new Ultra-Slow Muon beamline is being constructed to extend the μSR technique from bulk material to thin films, thus empowering a wide variety of surface and nano-science studies, and also a novel 3D imaging with the "ultra-slow muon microscope". Ultra-slow muons will be produced by the re-acceleration of thermal muons regenerated by the laser resonant ionization of muonium atoms evaporated from a hot tungsten foil, a method that originated from the Meson Science Laboratory at KEK. The design parameters, construction status and initial beam commissioning are reported.

  14. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    SciTech Connect

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; March-Leuba, Jose A; Thurston, Carl; Hudson, Nathanael H.; Ireland, A.; Wysocki, A.

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, the capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.

  15. Measurement of Vector Meson Decays in Nuclei at J-PARC

    NASA Astrophysics Data System (ADS)

    Morino, Y.; Aoki, K.; Aramaki, Y.; En'yo, H.; Hamagaki, H.; Kanaya, J.; Kanno, K.; Kawama, D.; Kiyomichi, A.; Komatsu, Y.; Masumoto, S.; Murakami, H.; Muto, R.; Nakai, W.; Naruki, M.; Obara, Y.; Ozawa, K.; Sakuma, F.; Sawada, S.; Sekimoto, M.; Shibukawa, T.; Shigaki, K.; Takahashi, T. N.; Watanabe, Y. S.; Yokkaichi, S.

    Mass modification of vector meson has been studied in order to investigate the restoration of the chiral symmetry in hot and/or dense matter. Systematical measurement is necessary to confirm the mass modification due to the chiral symmetry restoration. For this purpose, E16 experiment at J-PARC will detect the vector mesons via e + e - decay. A goal of the E16 experiment is to reveal the target mass dependence and the meson velocity dependence of the mass modification through systematic measurement. For that purpose, it is aimed to collect slowly moving φ with typical β γ < 1.25 via di-electron decay as many as possible. The experiment will be performed at the high momentum beam line at J-PARC hadron hall, which supplies a 30-GeV proton beam with an intensity of 2 × 1010 protons per pulse. To cope with the high particle-rate environment, GEMs are used in the E16 spectrometer as the main detectors. To observe a possible second peak due to the modified mass of the φ inside nuclei, 5 MeV/c2 is our goal for the mass resolution. Preparation of the spectrometer construction is now in progress for the first beam time planned at 2016.

  16. Double hypernuclei experiment with hybrid emulsion method (J-PARC E07)

    NASA Astrophysics Data System (ADS)

    Ekawa, Hiroyuki; J-APRC E07 Collaboration

    2014-09-01

    Double hypernuclei are important probes to study the system with strangeness -2. In order to search for double hypernuclei, an upgrade experiment is planned at J-PARC K1.8 beam line. In the experiment, the KURAMA spectrometer system will detect Ξ- production in the (K- ,K+) reaction on a diamond target. SSDs located the upstream and the downstream of emulsion plates will record Ξ- tracks which flight toward emulsion plates precisely. Tracks in SSDs and emulsion will be automatically connected by a hybrid method. Discoveries of more than 10 new double hypernuclear species are expected, which enable us to discuss binding energy in terms of mass number dependence. On the other hand, we will also observe X rays from Ξ- atoms with a Germanium detector array installed close to the emulsion by tagging Ξ-stopped events. This will be the first measurement in the world and give information on the Ξ-potential shape at the nuclear surface region. Emulsion production has been completely done and a test experiment for some detectors of KURAMA spectrometer was carried out. In this talk, physics motivation and current status of the J-PARC E07 experiment will be reported.

  17. The Modeling of Advanced BWR Fuel Designs with the NRC Fuel Depletion Codes PARCS/PATHS

    DOE PAGES

    Ward, Andrew; Downar, Thomas J.; Xu, Y.; ...

    2015-04-22

    The PATHS (PARCS Advanced Thermal Hydraulic Solver) code was developed at the University of Michigan in support of U.S. Nuclear Regulatory Commission research to solve the steady-state, two-phase, thermal-hydraulic equations for a boiling water reactor (BWR) and to provide thermal-hydraulic feedback for BWR depletion calculations with the neutronics code PARCS (Purdue Advanced Reactor Core Simulator). The simplified solution methodology, including a three-equation drift flux formulation and an optimized iteration scheme, yields very fast run times in comparison to conventional thermal-hydraulic systems codes used in the industry, while still retaining sufficient accuracy for applications such as BWR depletion calculations. Lastly, themore » capability to model advanced BWR fuel designs with part-length fuel rods and heterogeneous axial channel flow geometry has been implemented in PATHS, and the code has been validated against previously benchmarked advanced core simulators as well as BWR plant and experimental data. We describe the modifications to the codes and the results of the validation in this paper.« less

  18. Evaluation of turbulence models in the PARC code for transonic diffuser flows

    NASA Technical Reports Server (NTRS)

    Georgiadis, N. J.; Drummond, J. E.; Leonard, B. P.

    1994-01-01

    Flows through a transonic diffuser were investigated with the PARC code using five turbulence models to determine the effects of turbulence model selection on flow prediction. Three of the turbulence models were algebraic models: Thomas (the standard algebraic turbulence model in PARC), Baldwin-Lomax, and Modified Mixing Length-Thomas (MMLT). The other two models were the low Reynolds number k-epsilon models of Chien and Speziale. Three diffuser flows, referred to as the no-shock, weak-shock, and strong-shock cases, were calculated with each model to conduct the evaluation. Pressure distributions, velocity profiles, locations of shocks, and maximum Mach numbers in the duct were the flow quantities compared. Overall, the Chien k-epsilon model was the most accurate of the five models when considering results obtained for all three cases. However, the MMLT model provided solutions as accurate as the Chien model for the no-shock and the weak-shock cases, at a substantially lower computational cost (measured in CPU time required to obtain converged solutions). The strong shock flow, which included a region of shock-induced flow separation, was only predicted well by the two k-epsilon models.

  19. Three-dimensional spiral injection scheme for the g-2/EDM experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Iinuma, Hiromi; Nakayama, Hisayoshi; Oide, Katsunobu; Sasaki, Ken-ichi; Saito, Naohito; Mibe, Tsutomu; Abe, Mitsushi

    2016-10-01

    A newly developed three-dimensional spiral injection scheme for beam insertion into a solenoidal storage ring is reported. A new planned muon g-2/EDM experiment at J-PARC aims to measure g - 2 to a factor of 5 better statistical precision and a factor of 100 better sensitivity for the electric dipole moment (EDM) measurement compared to previous experiments. The J-PARC experiment will use a 3-T MRI solenoid magnet as the muon storage ring with a 0.66 m diameter to achieve a 1-ppm level of local uniformity. The previous g - 2 injection scheme is not applicable for beam injection into a small ring. The new scheme provides a smooth injection utilizing a radial solenoidal fringe field, without causing an error field in the storage volume. The expected storage efficiency is 80% and over, which is to be compared to 3.5% for the previous g - 2 experiment. In addition, the ability to control the storage plane is important for the EDM measurement. In this paper, we introduce the conceptual design and required beam parameters in terms of Twiss functions and the expected injection efficiency.

  20. First neutrino event detection with nuclear emulsion at J-PARC neutrino beamline

    NASA Astrophysics Data System (ADS)

    Fukuda, T.; Aoki, S.; Cao, S.; Chikuma, N.; Fukuzawa, Y.; Gonin, M.; Hayashino, T.; Hayato, Y.; Hiramoto, A.; Hosomi, F.; Ishiguro, K.; Iori, S.; Inoh, T.; Kawahara, H.; Kim, H.; Kitagawa, N.; Koga, T.; Komatani, R.; Komatsu, M.; Matsushita, A.; Mikado, S.; Minamino, A.; Mizusawa, H.; Morishima, K.; Matsuo, T.; Matsumoto, T.; Morimoto, Y.; Morishita, M.; Nakamura, K.; Nakamura, M.; Nakamura, Y.; Naganawa, N.; Nakano, T.; Nakaya, T.; Nakatsuka, Y.; Nishio, A.; Ogawa, S.; Oshima, H.; Quilain, B.; Rokujo, H.; Sato, O.; Seiya, Y.; Shibuya, H.; Shiraishi, T.; Suzuki, Y.; Tada, S.; Takahashi, S.; Yamada, K.; Yoshimoto, M.; Yokoyama, M.

    2017-06-01

    Precise neutrino-nucleus interaction measurements in the sub-multi-GeV region are important to reduce the systematic uncertainty in future neutrino oscillation experiments. Furthermore, an excess of {ν_e} interactions, as a possible interpretation of the existence of a sterile neutrino, has been observed in such an energy region. The nuclear emulsion technique can measure all the final state particles with low energy threshold for a variety of targets (Fe, C, H{_2}O, and so on). Its sub-μm position resolution allows measurements of the {ν_e} cross-section with good electron/gamma separation capability. We started a new experiment at J-PARC to study sub-multi-GeV neutrino interactions by introducing the nuclear emulsion technique. The J-PARC T60 experiment has been implemented as a first step in such a project. Systematic neutrino event analysis with full scanning data in the nuclear emulsion detector was performed for the first time. The first neutrino event detection and its analysis are described in this paper.

  1. WebParc: a tool for analysis of the topography and volume of stroke from MRI

    PubMed Central

    Haselgrove, Christian; Makris, Nikos; Goldin, Donald M.; Lev, Michael H.; Caplan, David; Caviness, Verne S.

    2010-01-01

    The quantitative assessment of the anatomic consequences of cerebral infarction is critical in the study of the etiology and therapeutic response in patients with stroke. We present here an overview of the operation of “WebParc,” a computational system that provides measures of stroke lesion volume and location with respect to canonical forebrain neural systems nomenclature. Using a web-based interface, clinical imaging data can be registered to a template brain that contains a comprehensive set of anatomic structures. Upon delineation of the lesion, we can express the size and localization of the lesion in terms of the regions that are intersected within the template. We demonstrate the application of the system using MRI-based diffusion-weighted imaging and document measures of the validity and reliability of its uses. Intra- and inter-rater reliability is demonstrated, and characterized relative to the various classes of anatomic regions that can be assessed. The WebParc system has been developed to meet criteria of both efficiency and intuitive operator use in the real time analysis of stroke anatomy, so as to be useful in support of clinical care and clinical research studies. This article is an overview of its base-line operation with quantitative anatomic characterization of lesion size and location in terms of stroke distribution within the separate gray and white matter compartments of the brain. PMID:20077026

  2. Σp Scattering Experiment at J-PARC (E40) and Its Development Status

    NASA Astrophysics Data System (ADS)

    Akazawa, Yuya

    We are planning to perform a Σ proton scattering experiment at J-PARC (J-PARC E40) in order to investigate the baryon-baryon interaction and to confirm the repulsive force due to the quark Pauli effect. In order to measure the cross section of Σp scattering, we will use a new detector system called CATCH and two spectrometer systems installed at the upstream and at the downstream of a liquid hydrogen target. The momenta of π beam and scattered K+ are analyzed by the spectrometers in order to reconstruct the momentum of a produced Σ particle. The scattering angle and the kinetic energy of recoil protons are measured by CATCH in order to identify Σp scattering events. CATCH consists of a Cylindrical Fiber Tracker (CFT) and 24 bismuth germanate (BGO) calorimeters. Development of CATCH is on going. Two layers of CFT were constructed and their efficiencies were evaluated to be 98 and 92% for the straight layer and the spiral layer, respectively. The energy resolution of 24 BGO calorimeters was better than 1% for 80 MeV proton beam. The construction of CATCH will be completed until the end of 2015 fiscal year.

  3. A Mutation in GIANT CHLOROPLAST Encoding a PARC6 Homolog Affects Spikelet Fertility in Rice.

    PubMed

    Kamau, Peter K; Sano, Shingo; Takami, Tsuneaki; Matsushima, Ryo; Maekawa, Masahiko; Sakamoto, Wataru

    2015-05-01

    Chloroplasts are not generated de novo but proliferate from a pre-existing population of plastids present in meristematic cells. Chloroplast division is executed by the co-ordinated action of at least two molecular machineries: internal machinery located on the stromal side of the inner envelope membrane and external machinery located on the cytosolic side of the outer envelope membrane. To date, molecular studies of chloroplast division in higher plants have been limited to several species such as Arabidopsis. To elucidate chloroplast division in rice, we performed forward genetics and isolated a mutant displaying large chloroplasts among an ethyl methanesulfonate (EMS)-mutagenized Oryza sativa spp japonica Nipponbare population. Using a map-based approach, this mutation, termed giant chloroplast (gic), was allocated in a gene that encodes a protein that is homologous to Paralog of ARC6 (PARC6), which is known to play a role in chloroplast division. GIC is unique in that it has a long C-terminal extension that is not present in other PARC6 homologs. Characterization of gic phenotypes in a rice field showed that gic exhibited defective growth in seed setting, suggesting that the gic mutant negatively affects the reproductive stage. This report is the first describing a chloroplast division mutant in monocotyledons and its effect on plant development. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  4. Outline for the Winter T-PARC (THORPEX Pacific-Asia Regional Campaign)

    NASA Astrophysics Data System (ADS)

    Asuma, Y.; Yamanouchi, T.; Toth, Z.

    2009-12-01

    For the purpose of improvement of 1-14 day high impact weather forecast, the wintertime THORPEX Pacific-Asia Regional Campaign (Winter T-PARC) was carried out by the lead organization of National Oceanic and Atmospheric Administration in United States from 12 January to the end of February 2008. Main observation platforms were enhanced upper air soundings in Siberia, Russia, two aircrafts (G-IV and C-130) for drop-sonde soundings. NOAA G-IV was located at Yokota AB in Tokyo, Japan and USAF C-130 was at Anchorage in Alaska, USA. As the rapidly deepening low pressure systems in the Northwestern Pacific region strongly affect downstream regions, such as Alaska, Arctic and entire North-American continent, they have a great contribution to the improvement of the forecasting in the Unite Sates and Canada. Winter T-PARC is assigned as a part of International Polar Year (IPY) program in the Unites States. National Institute of Polar Research in Japan supports the Winter T-PARC as a part of Japanese IPY activity. Using NCEPFNL dataset, temperature and moisture transportations and storm activities were analyzed over the North Pacific and Arctic regions from December 2008 to March 2009. As shown in Yoshida and Asuma (2004) and Kuwano-Yoshida and Asuma (2008), explosively deepening cyclones in the Northwestern Pacific region had distinct seasonal variations. That is, cyclones rapidly developed near the east coast of the Eurasian Continent (OJ cyclones) in December, moved quickly straightforward to the East in January (PO-L cyclones) and formed over the East China Sea where the south of Japan, moved to the Northward and developed over the east of Hokkaido (PO-O cyclones) in February and March. Figure shows monthly low pressure systems and their tracks in the Arctic region. Large amounts of heat and moisture flow into the Arctic region from the lower and mid latitudes through the Bearing Straight as well as the Norwegian Sea. Storms entered and traveled into the Arctic region

  5. First trial of the muon acceleration for J-PARC muon g-2/EDM experiment

    NASA Astrophysics Data System (ADS)

    Kitamura, R.; Otani, M.; Fukao, Y.; Kawamura, N.; Mibe, T.; Miyake, Y.; Shimomura, K.; Kondo, Y.; Hasegawa, K.; Bae, S.; Kim, B.; Razuvaev, G.; Iinuma, H.; Ishida, K.; Saito, N.

    2017-07-01

    Muon acceleration is an important technique in exploring the new frontier of physics. A new measurement of the muon dipole moments is planned in J-PARC using the muon linear accelerator. The low-energy (LE) muon source using the thin metal foil target and beam diagnostic system were developed for the world’s first muon acceleration. Negative muonium ions from the thin metal foil target as the LE muon source was successfully observed. Also the beam profile of the LE positive muon was measured by the LE-dedicated beam profile monitor. The muon acceleration test using a Radio-Frequency Quadrupole linac (RFQ) is being prepared as the first step of the muon accelerator development. In this paper, the latest status of the first muon acceleration test is described.

  6. Thermal Stress Analysis for a Transfer Line of Hydrogen Moderator in J-Parc

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Teshigawara, M.; Aso, T.; Ohtsu, K.; Maekawa, F.; Kato, T.

    2008-03-01

    An intense spallation neutron source (JSNS) driven by a 1-MW proton beam was constructed, as one of the main experimental facilities in J-PARC. In JSNS, supercritical hydrogen (1.5 MPa, 20 K) was selected as a moderator material. Three kinds of hydrogen moderator are installed (coupled, decoupled, and poisoned) to provide pulsed neutron beam with higher neutronic performance. The moderators contain cryogenic hydrogen transfer lines located in a radioactive area. Therefore, the transfer lines should be designed to have minimum pipe size and elbow-type bend sections to reduce the potential for radiation dose by radiation streaming. The design should also consider mechanical stress concentrations, deformation, and touching between the pipes due to the thermal shrinkage at the cryogenic hydrogen temperature. A FEM code analysis determined the appropriate locations of piping supporting spacers to keep the thermal stress below the allowable stress and to also avoid touching between the pipes.

  7. Diamond detector for beam profile monitoring in COMET experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    &Cbreve; erv, M.; Sarin, P.; Pernegger, H.; Vageeswaran, P.; Griesmayer, E.

    2015-06-01

    We present the design and initial prototype results of a proton beam profile monitor for the COMET experiment at J-PARC. The goal of COMET is to look for charged lepton flavor violation by direct μ to e conversion at a sensitivity of 10-19. The 8 GeV proton beam pulsed at 100 ns with 1010 protons/s will be used to create muons through pion production and decay. In the final experiment, the proton flux will be raised to 1014 protons/s to increase the sensitivity. These requirements of harsh radiation tolerance and fast readout make diamond a good choice for constructing a beam profile monitor in COMET. We present first results of the characterization of single crystal diamond (scCVD) sourced from a new company 2A SYSTEMS Singapore. Our measurements indicate excellent charge collection and high carrier mobility down to cryogenic temperatures.

  8. Neutron Lifetime Measurement Initiated at J-PARC/MLF/BL05

    NASA Astrophysics Data System (ADS)

    Tanaka, Genki; Yoshioka, Tamaki; Otono, Hidetoshi; Sumi, Naoyuki; Yamashita, Satoru; Katayama, Ryo; Yamada, Takahito; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Shimizu, Hirohiko; Kitaguchi, Masaaki; Hirota, Katsuya; Sakakibara, Risa; Sugino, Tomoaki; Iwashita, Yoshihisa; Kitahara, Ryunosuke; Oide, Hideyuki; Shima, Tatsushi; Ino, Takashi; Mishima, Kenji; Taketani, Kaoru; Seki, Yoshichika; NOP Collaboration

    2014-09-01

    The neutron lifetime τn is one of the important parameters for the Big Bang Nucleosynthesis (BBN) which predicts an abundance of the light elements in the early universe. However, the He/(H+He) ratio recently measured by Izotov et al. has been deviated from that of the BBN prediction. Thus a precise τn measurement is desired. Historically, there are two methods for τn measurement, and there exists 3.8 σ deviation between their results. We are therefore conducting the τn measurement at the J-PARC/MLF/BL05 by using a third method. In this experiment we count the number of decay electrons by using Time Projection Chamber (TPC). We expect 1% accuracy with the collected data in JFY 2014. In this presentation, we will report some analysis results and future plan.

  9. Neutron lifetime measurement with pulsed beam at J- PARC: TPC and DAQ

    NASA Astrophysics Data System (ADS)

    Yamada, Takahito; Katayama, Ryo; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Yamashita, Satoru; Sakakibara, Risa; Sugino, Tomoaki; Kitaguchi, Masaaki; Hirota, Katsuya; Shimizu, Hirohiko M.; Tanaka, Genki; Sumi, Naoyukio; Otono, Hidetoshi; Yoshioka, Tamaki; Kitahara, Ryunosuke; Iwashita, Yoshihisa; Oide, Hideyuki; Shima, Tatsushi; Seki, Yoshichika; Mishima, Kenji; Taketani, Kaoru; Ino, Takashi; NOP Collaboration

    2014-09-01

    The neutron lifetime is an important parameter for Big Bang nucleosynthesis (BBN). The best neutron lifetime measurements have uncertainties at the 0.1% level; however, they differ by 3.8 sigma. In order to resolve this discrepancy, we plan to measure the neutron lifetime using a method originally developed by Kossakowski et al. which is different from the other 0.1% accuracy experiments. In our method, which uses a pulsed cold neutron beam at J-PARC, the electrons from the beta decay of the neutron are detected with a time projection chamber (TPC). A small amount of 3He is added to the gas mixture in order to simultaneously measure the neutron flux. We report on the recent upgrade of the TPC and the Data Acquisition System which were used to take data during the period of February-June 2014.

  10. Modification of the PARC Navier-Stokes Code to predict rocket engine nozzle performance

    NASA Technical Reports Server (NTRS)

    Collins, Frank G.; Myruski, Bryan; Orr, Joseph L.

    1990-01-01

    The PARC2D Navier-Stokes Code was modified to compute the performance parameters for rocket engine nozzles. The perfect gas code was applied to the SSME engine nozzle for inviscid, laminar and turbulent flow. Inviscid computations compare well with Rocketdyne computations. Performance degradation due to the boundary layers is very reasonable. Application of the code to nontraditional nozzle geometries and to low Reynolds nozzles is demonstrated. Modification of the code for equilibrium H2/O2 chemistry is described. Thermodynamic and equilibrium constants are determined from statistical mechanics and the transport properties from exact kinetic theory, using collison integrals determined from appropriate intermolecular potentials. The equilibrium code was used to compute the SSME flowfield. Modifications of the flowfield due to the change of composition are described.

  11. The analysis of the OECD/NEA/NSC PBMR-400 benchmark problem using PARCS-DIREKT

    SciTech Connect

    Seker, V.; Downar, T. J.

    2006-07-01

    The OECD/NEA/NSC PBMR-400 benchmark problem was developed to support the validation and verification efforts for the PBMR design. This paper describes the analysis of this problem using the PARCS-DIREKT coupled code system. The benchmark problem involved the use of two different cross-section libraries, one which was generated from a VSOP equilibrium core calculation and has no dependence on core conditions. The second library provides for dependence on five state parameters and was designed for transient analysis. The paper here reports the steady-state cases using the VSOP set of cross-sections. The results are shown to be in good agreement with those of VSOP. Also reported here are the results of the steady-state thermal-hydraulic DIRECKT solution with a given power profile obtained from VSOP equilibrium core calculation. This analysis provides some insight as to the most important parameters in the design of PBMR-400. (authors)

  12. Development of wide dynamic range beam loss monitor system for J-PARC main ring

    NASA Astrophysics Data System (ADS)

    Satou, K.; Toyama, T.; Kamikubota, N.; Yamada, S.; Yoshida, S.

    2017-07-01

    The new beam loss monitor (BLM) system now in operation at the main ring of J- PARC consists of an isolated front-end current to voltage converter, a VME-based 24 bit ADC system. A dual detector system employs a proportional-type gas chamber (PBLM) and an air- filled ionization chamber (AIC). The system shows a wide dynamic range of 160 dB. It can detect the low level signal that would arise in the case of the detection of residual dose in the ring itself after the beam has been turned off as well as an event such as high level beam loss at the collimators. The signal rise time of the waveform obtained is 17 µs which is fast enough to meet the speed requirement of the Machine Protection System (MPS); which is that the MPS should dump the beam within 100 µs when the beam loss signal exceeds the reference levels set in the ADC system.

  13. Electron cloud simulations for the main ring of J-PARC

    NASA Astrophysics Data System (ADS)

    Yee-Rendon, Bruce; Muto, Ryotaro; Ohmi, Kazuhito; Satou, Kenichirou; Tomizawa, Masahito; Toyama, Takeshi

    2017-07-01

    The simulation of beam instabilities is a helpful tool to evaluate potential threats against the machine protection of the high intensity beams. At Main Ring (MR) of J-PARC, signals related to the electron cloud have been observed during the slow beam extraction mode. Hence, several studies were conducted to investigate the mechanism that produces it, the results confirmed a strong dependence on the beam intensity and the bunch structure in the formation of the electron cloud, however, the precise explanation of its trigger conditions remains incomplete. To shed light on the problem, electron cloud simulations were done using an updated version of the computational model developed from previous works at KEK. The code employed the signals of the measurements to reproduce the events seen during the surveys.

  14. New μSR spectrometer at J-PARC MUSE based on Kalliope detectors

    NASA Astrophysics Data System (ADS)

    Kojima, K. M.; Murakami, T.; Takahashi, Y.; Lee, H.; Suzuki, S. Y.; Koda, A.; Yamauchi, I.; Miyazaki, M.; Hiraishi, M.; Okabe, H.; Takeshita, S.; Kadono, R.; Ito, T.; Higemoto, W.; Kanda, S.; Fukao, Y.; Saito, N.; Saito, M.; Ikeno, M.; Uchida, T.; Tanaka, M. M.

    2014-12-01

    We developed a new positron detector system called Kalliope, which is based on multi-pixel avalanch photo-diode (m-APD), application specific integrated circuit (ASIC), field programmable gated array (FPGA) and ethernet-based SiTCP data transfer technology. We have manufactured a general-purpose spectrometer for muon spin relaxation (μSR) measurements, employing 40 Kalliope units (1280 channels of scintillators) installed in a 0.4 T longitudinal-field magnet. The spectrometer has been placed at D1 experimental area of J- PARC Muon Science Establishment (MUSE). Since February of 2014, the spectrometer has been used for the user programs of MUSE after a short commissioning period of one week. The data accumulation rate of the new spectrometer is 180 million positron events per hour (after taking the coincidence of two scintillators of telescopes) from a 20×20 mm sample for double-pulsed incoming muons.

  15. Development of a polarized 3He neutron spin filter for POLANO at J-PARC

    NASA Astrophysics Data System (ADS)

    Ino, T.; Ohkawara, M.; Ohoyama, K.; Yokoo, T.; Itoh, S.; Nambu, Y.; Fujita, M.; Kira, H.; Hayashida, H.; Hiroi, K.; Sakai, K.; Oku, T.; Kakurai, K.

    2017-06-01

    We have developed a polarized 3He neutron spin filter (NSF) for a new polarized neutron spectrometer, POLANO, at the Japan Proton Accelerator Research Complex (J-PARC). POLANO aims to utilize high energy neutrons polarized by a 3He NSF and spin analyzed by an array of magnetic supermirrors for inelastic neutron scattering. The 3He gas is continuously polarized in-situ by spin-exchange optical pumping to provide a highly and stably polarized neutron beam. The POLANO 3He NSF is designed to polarize neutrons with energies as high as 200 meV and fit in a restricted space. It is equipped with adiabatic fast passage NMR that enables one to flip the 3He spins, and consequently, the neutron spins.

  16. Operation status of the J-PARC RF-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Shibata, T.; Nanmo, K.; Ueno, A.; Shinto, K.

    2017-08-01

    A cesiated RF-driven negative hydrogen ion source was started to operate in September, 2014 in response to the need for upgrading J-PARC's linac beam current. The ion source mainly comprises a stainless-steel plasma chamber, a beam extractor, and a large vacuum chamber with two turbo molecular pumps of 1500 L/s for differential pumping. The ion source has been successfully providing the required beam current to the accelerator without any significant issues other than a single-incident antenna failure occurred in October, 2014. Continuous operation for approximately 1,350 h was achieved with a beam current and duty factor of 45 mA and 1.25 % (0.5 msec and 25 Hz), respectively.

  17. Modification of the PARC Navier-Stokes Code to predict rocket engine nozzle performance

    NASA Technical Reports Server (NTRS)

    Collins, Frank G.; Myruski, Bryan; Orr, Joseph L.

    1990-01-01

    The PARC2D Navier-Stokes Code was modified to compute the performance parameters for rocket engine nozzles. The perfect gas code was applied to the SSME engine nozzle for inviscid, laminar and turbulent flow. Inviscid computations compare well with Rocketdyne computations. Performance degradation due to the boundary layers is very reasonable. Application of the code to nontraditional nozzle geometries and to low Reynolds nozzles is demonstrated. Modification of the code for equilibrium H2/O2 chemistry is described. Thermodynamic and equilibrium constants are determined from statistical mechanics and the transport properties from exact kinetic theory, using collison integrals determined from appropriate intermolecular potentials. The equilibrium code was used to compute the SSME flowfield. Modifications of the flowfield due to the change of composition are described.

  18. Ultra slow muon microscopy by laser resonant ionization at J-PARC, MUSE

    NASA Astrophysics Data System (ADS)

    Miyake, Y.; Ikedo, Y.; Shimomura, K.; Strasser, P.; Kawamura, N.; Nishiyama, K.; Koda, A.; Fujimori, H.; Makimura, S.; Nakamura, J.; Nagatomo, T.; Kadono, R.; Torikai, E.; Iwasaki, M.; Wada, S.; Saito, N.; Okamura, K.; Yokoyama, K.; Ito, T.; Higemoto, W.

    2013-04-01

    As one of the principal muon beam line at the J-PARC muon facility (MUSE), we are now constructing a Muon beam line (U-Line), which consists of a large acceptance solenoid made of mineral insulation cables (MIC), a superconducting curved transport solenoid and superconducting axial focusing magnets. There, we can extract 2 × 108/s surface muons towards a hot tungsten target. At the U-Line, we are now establishing a new type of muon microscopy; a new technique with use of the intense ultra-slow muon source generated by resonant ionization of thermal Muonium (designated as Mu; consisting of a μ + and an e - ) atoms generated from the surface of the tungsten target. In this contribution, the latest status of the Ultra Slow Muon Microscopy project, fully funded, is reported.

  19. Polarization analysis for magnetic field imaging at RADEN in J-PARC/MLF

    NASA Astrophysics Data System (ADS)

    Shinohara, Takenao; Hiroi, Kosuke; Su, Yuhua; Kai, Tetsuya; Nakatani, Takeshi; Oikawa, Kenichi; Segawa, Mariko; Hayashida, Hirotoshi; Parker, Joseph D.; Matsumoto, Yoshihiro; Zhang, Shuoyuan; Kiyanagi, Yoshiaki

    2017-06-01

    Polarized neutron imaging is an attractive method for visualizing magnetic fields in a bulk object or in free space. In this technique polarization of neutrons transmitted through a sample is analyzed position by position to produce an image of the polarization distribution. In particular, the combination of three-dimensional spin analysis and the use of a pulsed neutron beam is very effective for the quantitative evaluation of both field strength and direction by means of the analysis of the wavelength dependent polarization vector. Recently a new imaging instrument “RADEN” has been constructed at the beam line of BL22 of the Materials and Life Science Experimental Facility (MLF) at J-PARC, which is dedicated to energy-resolved neutron imaging experiments. We have designed a polarization analysis apparatus for magnetic field imaging at the RADEN instrument and have evaluated its performance.

  20. Wintertime component of the THORPEX Pacific-Asian Regional Campaign (T-PARC)

    NASA Astrophysics Data System (ADS)

    Song, Y.; Toth, Z.; Asuma, Y.; Reynolds, C.; Lngland, R.; Szunyogh, I.; Colle, B.; Chang, E.; Doyle, C.; Kats, A.

    2009-04-01

    The winter component of the T-PARC is an international field project that aims at improving high impact weather event forecasts for North America. The main objective is to understand how perturbations from the tropics, Eurasia and polar fronts travel through waveguide and turn into high impact weather events. Through adaptive observations by using manned aircrafts (NOAA G-IV and US Air force C-130s) and Russian rawinsonde network over data sparse regions, it is expected that accurate initial conditions will improve the numerical weather forecasts. Non-adaptive aircraft measurements over the Pacific Rim and part of India are also deployed through E-AMDAR program, which is expected to improve the background field over Asia where perturbations are initiated. The campaign is led by NOAA and joined by agencies and universities from US, Canada, Mexico, Japan, ECWMF, and Russia. While most observational data will be assimilated by operational centers to improve real time numerical weather predictions, post field studies will focus on aspects such as: data impact on forecast and analysis, dry and moist processes that affect the formation and propagation of perturbations, meso-scale storm structure, error growth, forecast "busts" under certain atmospheric regimes, and socio-economic applications such as costs and benefits of improved forecasts and their use by the public for high impact weather events. In particular, a Winter Olympics demonstration project (February 12 - February 28) is expected to be a test bed during winter T-PARC for real user outreach and application purposes. Effectiveness of existing targeting methods as well as new targeting methods in the 3-5 day lead time range will be pursued and other aspects related to data assimilation and numerical forecasts (both deterministic and ensemble forecasts) will be investigated within this project as well.

  1. Search for New Physics with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi; TREK/E36 Collaboration

    2016-03-01

    The E36 experiment conducted at J-PARC in Japan will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model (SM). The SM prediction for the ratio of leptonic K+ decays is very precise with an uncertainty of △RK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide clear indication of New Physics beyond the SM. The detector apparatus allows sensitivity to search for light U (1) gauge bosons and sterile neutrinos below 300 MeV /c2 , which could be associated with dark matter or explain established muon-related anomalies such as the muon g - 2 value, and perhaps the proton radius puzzle. The experiment was set up at the J-PARC K1.1BR kaon beamline in the fall of 2014, fully commissioned in the spring of 2015 and completed production data accumulation in Dec 2015. A scintillating fiber target was used to stop a beam of up to 1.2 Million K+ per spill. The K+ products were detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a CsI(TI) photon detector and particle ID systems. The status of the data analysis will be presented. This work has been supported by DOE awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  2. HUMAN RIGHTS ASSESSMENT IN PARC JEAN MARIE VINCENT, PORT-AU-PRINCE, HAITI

    PubMed Central

    Cullen, Kimberly A.; Ivers, Louise C.

    2014-01-01

    Months after a 7.0 magnitude earthquake hit Port-au-Prince, Haiti, over one million remain homeless and living in spontaneous internally displaced person (IDP) camps. Billions of dollars from aid organizations and government agencies have been pledged toward the relief effort, yet many basic human needs, including food, shelter, and sanitation, continue to be unmet. The Sphere Project, “Humanitarian Charter and Minimum Standards in Disaster Response,” identifies the minimum standards to be attained in disaster response. From a human rights perspective and utilizing key indicators from the Sphere Project as benchmarks, this article reports on an assessment of the living conditions approximately 12 weeks after the earthquake in Parc Jean Marie Vincent, a spontaneous IDP camp in Port-au-Prince. A stratified random sample of households in the camp, proportionate to the number of families living in each sector, was selected. Interview questions were designed to serve as “key indicators” for the Sphere Project minimum standards. A total of 486 interviews were completed, representing approximately 5% of households in each of the five sectors of the camp. Our assessment identified the relative achievements and shortcomings in the provision of relief services in Parc Jean Marie Vincent. At the time of this survey, the Sphere Project minimum standards for access to health care and quantity of water per person per day were being met. Food, shelter, sanitation, and security were below minimum accepted standard and of major concern. The formal assessment reported here was completed by September 2010, and is necessarily limited to conditions in Haiti before the cholera outbreak in October. PMID:21178190

  3. Application of modified REFIT code for J-PARC/MLF to evaluation of neutron capture cross section on 155,157Gd

    NASA Astrophysics Data System (ADS)

    Mizuyama, Kazuhito; Iwamoto, Nobuyuki; Iwamoto, Osamu; Hasemi, Hiroyuki; Kino, Koichi; Kimura, Atsushi; Kiyanagi, Yoshiaki

    2017-09-01

    In order to analyze the experimental data measured by the Accurate Neutron-Nucleus Reaction Measurement Instrument (ANNRI) at the Japan Proton Accelerator Research Complex/Materials and Life Science Experimental Facility (J-PARC/MLF), it is necessary to take into account the double-bunch structure of the neutron pulse and the energy resolution function for the operational condition of the J-PARC/MLF. The modified REFIT code has been developed to treat the double-bunch neutron pulse and the energy resolution function for J-PARC/MLF. In this study, we applied the modified REFIT code to analyze the new data of the neutron capture cross section of 155Gd and 157Gd recently measured by ANNRI in the J-PARC/MLF, and obtained the resonance parameters of two Gd isotopes. We discussed the differences between the our obtained results and the other libraries.

  4. Pre-conditioning procedure suitable for internal-RF-antenna of J-PARC RF-driven H⁻ ion source.

    PubMed

    Ueno, A; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Oguri, H

    2016-02-01

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H(-) ion source has been successfully operated for about 1 yr. By the world brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. Although no internal-RF-antenna failure, except for the once caused by an excess cesium due to a misoperation, occurred in the operation, many antennas failed in pre-conditionings for the first hundred days. The antenna failure rate was drastically decreased by using an antenna with coating thicker than a standard value and the pre-conditioning procedure repeating 15 min 25 kW RF-power operation and impurity-gas evacuation a few times, before the full power (50 kW) operation.

  5. Detection of parC mutations in Streptococcus pneumoniae by Real-time PCR and Taqman-MGB probes.

    PubMed

    Alonso, Rodrigo; Mateo, Estibaliz; Cisterna, Ramón

    2007-04-01

    A Real-time PCR assay was developed by using Taqman-MGB probes to screen mutations at codons Ser79 and Asp83 of Streptococcus pneumoniae parC. One hundred and thirty levofloxacin-susceptible and forty-two levofloxacin-resistant clinical strains were assayed. Mutations at codon 79 were found among all the levofloxacin-resistant strains. Mutations at codon 79 or 83 were found in ten levofloxacin-susceptible strains. This procedure is a reliable method for a rapid detection of mutations in the QRDRs of parC gene of S. pneumoniae and could be carried out in a diagnostic laboratory for some high-risk patients or in epidemiological surveys.

  6. Fine-tuning to minimize emittances of J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Oguri, H.

    2016-02-15

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H{sup −} ion source has been successfully operated for about one year. By the world’s brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. In order to minimize the transverse emittances, the rod-filter-field (RFF) was optimized by changing the triple-gap-lengths of each of pairing five piece rod-filter-magnets. The larger emittance degradation seems to be caused by impurity-gases than the RFF. The smaller beam-hole-diameter of the extraction electrode caused the more than expected improvements on not only the emittances but also the peak beam intensity.

  7. Improvements of Low Level RF Control Systems for J-PARC LINAC 400-MeV Upgrade

    NASA Astrophysics Data System (ADS)

    Fang, Z.; Futatsukawa, K.; Fukui, Y.; Kobayashi, T.; Michizono, S.; Sato, F.; Shinozaki, S.; Chishiro, E.

    The low level RF (LLRF) control systems have been successfully improved for the J-PARC LINAC upgrade. After the installation of 972-MHz high-β acceleration section behind the 324-MHz low-β section beginning in the summer of 2013, the proton beam was successfully accelerated to 400 MeV in January 2014. Many improvements in the LLRF control systems have been carried out to facilitate the operation of the J-PARC LINAC at 400 MeV. The reference 12-MHz signal delay settings for the feedback control systems have been optimized using 12-MHz delay modules. The stability performances of the 972-MHz RF&CLK (Clock) and Mixer&IQ (Mixer & IQ-modulator) boards have been improved using temperature-compensation techniques. By improving the hardware of the feedback control systems, very good stability of the RF systems has been achieved.

  8. Upgrade of PARC2D to include real gas effects. [computer program for flowfield surrounding aeroassist flight experiment

    NASA Technical Reports Server (NTRS)

    Saladino, Anthony; Praharaj, Sarat C.; Collins, Frank G.; Seaford, C. Mark

    1990-01-01

    This paper presents a description of the changes and additions to the perfect gas PARC2D code to include chemical equilibrium effects, resulting in a code called PARCEQ2D. The work developed out of a need to have the capability of more accurately representing the flowfield surrounding the aeroassist flight experiment (AFE) vehicle. Use is made of the partition function of statistical mechanics in the evaluation of the thermochemical properties. This approach will allow the PARC code to be extended to thermal nonequilibrium when this task is undertaken in the future. The transport properties follow from formulae from the kinetic theory of gases. Results are presented for a two-dimensional AFE that compare perfect gas and real gas solutions at flight conditions, showing vast differences between the two cases.

  9. PARC3D calculations of the F/A-18A HARV inlet vortex generators

    NASA Technical Reports Server (NTRS)

    Podleski, Steve D.

    1995-01-01

    NASA Lewis Research Center is currently engaged in a research effort as a team member of the High Alpha Technology Program within the NASA agency. This program uses a specially-equipped F/A-18A aircraft called the High Alpha Research Vehicle (HARV), in an effort to improve the maneuverability of high performance military aircraft at low-subsonic-speed, high-angle-of-attack conditions. The overall objective of the NASA Lewis effort is to develop inlet analysis technology towards efficient airflow delivery to the engine during these maneuvers. One portion of this inlet analysis technology uses computational fluid dynamics to predict installed inlet performance. Most of the F/A-18A HARV geometry, which includes the ramp/splitter plate, side diverter and slot, inlet lip and upper diverter, and deflected leading-edge flap has been modeled. The empennage and rear fuselage have not. A pair of vortex generators located on the bottom wall of the inlet were not modeled initially. These vortex generators were installed to alleviate any flow separation that may be induced by the wheel well protrusion into the inlet wall. Calculations completed with the PARC3D code showed that the pressure recovery has been underpredicted and the flow distortion over-predicted. To improve the correlation of PARC3D predictions with flight and wind tunnel tests, the vortex generators were included in the grid geometry and the results are presented in this report. The grid totals 27 blocks or 1.3 million grid points for the half model, which includes the vortex generator grid blocks. Two flight cases were calculated, a high speed case with a Mach number of 0.8 and angle of attack of 3.4; and a low speed case with a Mach number of 0.43 and angle of attack of 32.2. The vortex generators have a significant effect on the inlet boundary layers at high speed, low angle of attack; and have no effect at low speed, high angle of attack.

  10. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK Collaboration

    2014-09-01

    The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. The TREK/E36 experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. The experiment uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. With the aim to test lepton universality in the Ke 2 /Kμ 2 ratio with high precision, the experiment is highly sensitive to new physics beyond the Standard Model. A further goal of E36 is to search for light new particles with masses up to a few hundred MeV/c2 such as sterile neutrinos or U(1) bosons, which could be associated with dark matter or explain established muon-related anomalies. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  11. Design of the Large Acceptance Muon Beamline at J-PARC

    NASA Astrophysics Data System (ADS)

    Nakahara, K.; Miyake, Y.; Shimomura, K.; Strasser, P.; Nishiyama, K.; Kawamura, N.; Fujimori, H.; Makimura, S.; Koda, A.; Nagamine, K.; Ogitsu, T.; Yamamoto, A.; Adachi, T.; Sasaki, K.; Tanaka, K.; Kimura, N.; Makida, Y.; Ajima, Y.; Ishida, K.; Matsuda, Y.

    2008-02-01

    The Materials and Life Science Facility (MLF) is currently under construction at J-PARC in Tokai, Japan. The muon section of the facility will house the muon production target and four secondary beamlines used to transport the muons into two experimental halls. One of the beamlines is a large acceptance beamline (the so called Super Omega Muon beamline) which, when completed, will produce the largest intensity pulse muon beam in the world. The expected rate of surface muons for this beamline is 5×108μ+/s, and a cloud muon rate of 107μ-/s. The extracted muons will be used for projects involving the production of ultra-slow muons as well as for muon-catalyzed fusion. The beamline consists of the normal-conducting capture solenoids, the superconducting curved transport solenoids, and the Dai Omega-type axial focusing magnet. Currently, the capture and transport solenoids are under design, with the former in its final stages and the latter being finalized for construction of test coils. The design of the Dai Omega-type axial focusing magnet is under consideration with particular emphasis on its compatibility with the transport solenoids.

  12. Operational characteristics of the J-PARC cryogenic hydrogen system for a spallation neutron source

    SciTech Connect

    Tatsumoto, Hideki; Ohtsu, Kiichi; Aso, Tomokazu; Kawakami, Yoshihiko; Teshigawara, Makoto

    2014-01-29

    The J-PARC cryogenic hydrogen system provides supercritical hydrogen with the para-hydrogen concentration of more than 99 % and the temperature of less than 20 K to three moderators so as to provide cold pulsed neutron beams of a higher neutronic performance. Furthermore, the temperature fluctuation of the feed hydrogen stream is required to be within ± 0.25 K. A stable 300-kW proton beam operation has been carried out since November 2012. The para-hydrogen concentrations were measured during the cool-down process. It is confirmed that para-hydrogen always exists in the equilibrium concentration because of the installation of an ortho-para hydrogen convertor. Propagation characteristics of temperature fluctuation were measured by temporarily changing the heater power under off-beam condition to clarify the effects of a heater control for thermal compensation on the feed temperature fluctuation. The experimental data gave an allowable temperature fluctuation of ± 1.05 K. It is clarified through a 286-kW and a 524-kW proton beam operations that the heater control would be applicable for the 1-MW proton beam operation by extrapolating from the experimental data.

  13. Search for New Physics with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi H.; TREK Collaboration

    2016-09-01

    We are potentially standing at the precipice in searching for New Physics (NP) beyond the Standard Model (SM) by performing a precision test of lepton universality - a basic assumption of the SM that assigns an identical coupling constant to e, μ and τ. Experiment E36 conducted at J-PARC in Japan will test lepton universality in the RK = Γ (Ke 2) / Γ (Kμ 2) ratio. The SM prediction of leptonic K+ decays is highly precise with an uncertainty of △RK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide clear indication of NP beyond the SM. Although a successful description of the basic building blocks of matter, the SM is incomplete, falling short to describe dark matter, baryogenesis, neutrino masses and much more. The E36 detector apparatus allows sensitivity to search for light U (1) gauge bosons and sterile neutrinos, which could be associated with dark matter or explain established muon-related anomalies such as the muon g-2 value, and perhaps the proton radius puzzle. A scintillating fiber target was used to stop K+ beam. The K+ products were detected with large-acceptance toroidal spectrometer. Status of data analysis will be presented. This work has been supported by DOE Awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  14. A beam position monitor for the diagnostic line in MEBT2 of J-PARC linac

    NASA Astrophysics Data System (ADS)

    Miura, A.; Tamura, J.; Kawane, Y.

    2017-07-01

    In the linac of the Japan Proton Accelerator Research Complex (J-PARC), the neutral hydrogen (H0) beam from the negative hydrogen ion (H-) beam is one of key issues in mitigating beam losses. To diagnose H0 particles, we installed a set of beam-bump magnets to generate a chicane orbit of the H- beam. The beam position monitors (BPMs) in the beam line are used for orbit correction to maintain the beam displacement within 2.0 mm from the duct center. To measure the beam displacement under different drive currents of the beam-bump magnets, a new wide-range BPM was designed and manufactured to evaluate the horizontal beam position by using a correction function to compensate for non-linearity. We also employed the beam profile monitor (WSM: wire scanner monitor) to measure the H- beam profile, which helped us to compare the beam position measurements. In this paper, the design and the performance of the wide-range BPM are described. In addition, we present a comparison of the beam position measured by the BPM and the WSM.

  15. The Realignment of the Beamline for J-PARC 3 GeV RCS

    NASA Astrophysics Data System (ADS)

    Tani, Norio; Yamamoto, Masanobu; Kamiya, Junichiro; Hotchi, Hideaki; Kinsho, Michikazu

    J-PARC 3-GeV RCS suffered from the misalignments of several millimeters of the magnets in both horizontal and vertical directions caused by the Tohoku Region Pacific Coast Earthquake on 11th March, 2011. As the result of the orbit calculation showed that the beam loss was acceptable for beam operation at 300 kW, beam operation with the current placement was implemented until May, 2013. However according to the beam loss simulation, the beam loss increased and the horizontal emittance expanded at 1 MW operation. The collimator aperture of RCS was designed at 324 π mm mrad. The ring acceptance of RCS is 486 π mm mrad. The ring acceptance can secure good collimation efficiency of 97% by taking the aperture ratio which is 1.5 times of collimator aperture. The realignment of the RCS beamline must secure ring acceptance in order to perform the 1 MW operation. In this paper, the alignment results of the magnets and the ceramic chambers that constitute the beamline of 3-GeV RCS are reported.

  16. Status of the TREK/E36 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Kohl, Michael; TREK/E36 Collaboration

    2015-04-01

    The TREK/E36 experiment will provide a precision test of lepton universality in the Ke 2 /Kμ 2 ratio to search for new physics beyond the Standard Model. Simultaneously it will search for light U(1) gauge bosons and sterile neutrinos below 300 MeV/c2, which could be associated with dark matter or explain established muon-related anomalies such as the muon anomalous magnetic moment and the proton radius puzzle. The experiment is scheduled to run in 2015 at the J-PARC K1.1BR kaon beamline. It uses a scintillating fiber target to stop a beam of up to 106 positive kaons per second. The kaon decay products are detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a photon calorimeter with large solid angle and redundant particle identification systems. An overview of the planned experiment and the current project status will be presented. This project has been supported by DOE Early Career Award DE-SC0003884.

  17. Neutron lifetime measurement with pulsed beam at J-PARC:Incident Beam Flux

    NASA Astrophysics Data System (ADS)

    Sakakibara, Risa; Shimizu, Hirohiko M.; Kitaguchi, Masaaki; Hirota, Katsuya; Sugino, Tomoaki; Yamashita, Satoru; Katayama, Ryo; Yamada, Takahito; Higashi, Nao; Yokoyama, Harumichi; Sumino, Hirochika; Yoshioka, Tamaki; Otono, Hidetoshi; Tanaka, Genki; Sumi, Naoyuki; Iwashita, Yoshihisa; Kitahara, Ryunosuke; Oide, Hideyuki; Shima, Tatsushi; Ino, Takashi; Mishima, Kenji; Taketani, Kaoru; Seki, Yoshichika; NOP Collaboration

    2014-09-01

    The neutron lifetime is one of the important parameters in the estimation of the abundance of the light elements in the early universe through the Big Bang Nucleosynthesis (BBN). The accuracy of 0.1% is desired in the neutron lifetime to quantitatively discuss the BBN in combination with the observation of the anisotropy of the cosmic microwave. We have started a lifetime measurement with pulsed neutrons at J-PARC/BL05. To measure the lifetime, we detect the decay electrons from the bunched neutrons and the incident neutron flux in the TPC at the same time. By diluting a small amount of 3He gas into the TPC, the incident flux is estimated by counting protons via 3He(n,p)3H reactions. The accuracy of the selection of 3He(n,p)3H events and the influence of the contamination of nitrogen gas are the major systematic errors. In this paper, the estimation of the systematic error in the incident flux is reported.

  18. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    SciTech Connect

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; Aronson, A.; Diamond, D.; Yarsky, P.

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculation pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.

  19. Design of hydrogen vent line for the cryogenic hydrogen system in J-PARC

    NASA Astrophysics Data System (ADS)

    Tatsumoto, Hideki; Aso, Tomokazu; Kato, Takashi; Ohtsu, Kiichi; Hasegawa, Shoichi; Maekawa, Fujio; Futakawa, Masatoshi

    2009-02-01

    As one of the main experimental facilities in J-PARC, an intense spallation neutron source (JSNS) driven by a 1-MW proton beam selected supercritical hydrogen at a temperature of 20 K and a pressure of 1.5 MPa as a moderator material. Moderators are controlled by a cryogenic hydrogen system that has a hydrogen relief system, which consists of high and low pressure stage of manifolds, a hydrogen vent line and a stack, in order to release hydrogen to the outside safely. The design of the hydrogen vent line should be considered to prevent purge nitrogen gas in the vent line from freezing when releasing the cryogenic hydrogen, to prevent moisture in the stack placed in an outdoor location from freezing, and to inhibit large piping temperature reduction at a building wall penetration. In this work, temperature change behaviors in the hydrogen vent line were analyzed by using a CFD code, STAR-CD. We determined required sizes of the vent line based on the analytical results and its layout in the building.

  20. Computation of Supersonic Jet Mixing Noise Using PARC Code With a kappa-epsilon Turbulence Model

    NASA Technical Reports Server (NTRS)

    Khavaran, A.; Kim, C. M.

    1999-01-01

    A number of modifications have been proposed in order to improve the jet noise prediction capabilities of the MGB code. This code which was developed at General Electric, employees the concept of acoustic analogy for the prediction of turbulent mixing noise. The source convection and also refraction of sound due to the shrouding effect of the mean flow are accounted for by incorporating the high frequency solution to Lilley's equation for cylindrical jets (Balsa and Mani). The broadband shock-associated noise is estimated using Harper-Bourne and Fisher's shock noise theory. The proposed modifications are aimed at improving the aerodynamic predictions (source/spectrum computations) and allowing for the non- axisymmetric effects in the jet plume and nozzle geometry (sound/flow interaction). In addition, recent advances in shock noise prediction as proposed by Tam can be employed to predict the shock-associated noise as an addition to the jet mixing noise when the flow is not perfectly expanded. Here we concentrate on the aerodynamic predictions using the PARC code with a k-E turbulence model and the ensuing turbulent mixing noise. The geometry under consideration is an axisymmetric convergent-divergent nozzle at its design operating conditions. Aerodynamic and acoustic computations are compared with data as well as predictions due to the original MGB model using Reichardt's aerodynamic theory.

  1. Computation of nozzle flow fields using the PARC2D Navier-Stokes code

    NASA Technical Reports Server (NTRS)

    Collins, Frank G.

    1986-01-01

    Supersonic nozzles which operate at low Reynolds numbers and have large expansion ratios have very thick boundary layers at their exit. This leads to a very strong viscous/inviscid interaction upon the flow within the nozzle and the traditional nozzle design techniques which correct the inviscid core with a boundary layer displacement do not accurately predict the nozzle exit conditions. A full Navier-Stokes code (PARC2D) was used to compute the nozzle flow field. Grids were generated using the interactive grid generator code TBGG. All computations were made on the NASA MSFC CRAY X-MP computer. Comparison was made between the computations and in-house wall pressure measurements for CO2 flow through a conical nozzle having an area ratio of 40. Satisfactory agreement existed between the computations and measurements for a stagnation pressure of 29.4 psia and stagnation temperature of 1060 R. However, agreement did not exist at a stagnation pressure of 7.4 psia. Several reasons for the lack of agreement are possible. The computational code assumed a constant gas gamma whereas gamma for CO2 varied from 1.22 in the plenum chamber to 1.38 at the nozzle exit. Finally, it is possible that condensation occurred during the expansion at the lower stagnation pressure.

  2. Simulation and Track Reconstruction Techniques for the J-PARC muon g-2 experiment

    NASA Astrophysics Data System (ADS)

    Tsilias, Paschalis; Lee, Myeong Jae

    2017-03-01

    The Muon g-2/EDM proposed experiment at J-PARC is a promising and innovative attempt at the field of Precision Physics. The sensitivity goal of 0.1 ppm will test the limits of our current understanding, and may probe for Beyond the Standard Model observations. This paper seeks out to investigate the computational techniques required by the experiment. The GEANT4 [1] framework was used to simulate the detector setup, according to the experiment's Conceptual Design Report (CDR) [2]. This allowed to observe the event hierarchy in different energies, generate signal hit data, and construct an event-selection algorithm. ROOT and GDML enabled us to use the geometry and parsed output data in a platform-independent way. Using techniques pertaining to Machine Learning and Image Feature extraction, such as the Canny Edge detection and the Hough Transform, we were able to construct a generic representation of `track families' from each event category. Finally, the modular GENFIT2 [3] framework was used to implement the Kalman Filter [4] along with an Deterministic Annealing Filter (DAF) [5] and the Runge-Kutta stepper to reconstruct tracks from a few digitized, smeared singular event data.

  3. SUPERCONDUCTING COMBINED FUNCTION MAGNET SYSTEM FOR J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    OGITSU, T.; AJIMA, Y.; ANERELLA, M.; ESCALLIER, J.; GANETIS, G.; GUPTA, R.; HAGEDOM, D.; HARRISON, M.; HIGASHI, N.; IWAMOTO, Y.; ICHIKAWA, A.; JAIN, A.; KIMURA, N.; KOBAYASHI, T.; MAKIDA, Y.; MURATORE, J.; NAKAMOTO, T.; OHHATA, H.; TAKASAKI, N.; TANAKA, K.; TERASHIMA, A.; YAMOMOTO, A.; OBANA, T.; PARKER, B.; WANDERER, P.

    2004-10-03

    The J-PARC Neutrino Experiment, the construction of which starts in JFY 2004, will use a superconducting magnet system for its primary proton beam line. The system, which bends the 50 GeV 0.75 MW proton beam by about 80 degrees, consists of 28 superconducting combined function magnets. The magnets utilize single layer left/right asymmetric coils that generate a dipole field of 2.6 T and a quadrupole field of 18.6 T/m with the operation current of about 7.35 kA. The system also contains a few conduction cooled superconducting corrector magnets that serve as vertical and horizontal steering magnets. All the magnets are designed to provide a physical beam aperture of 130 mm in order to achieve a large beam acceptance. Extensive care is also required to achieve safe operation with the high power proton beam. The paper summarizes the system design as well as some safety analysis results.

  4. The origin of magnetic alloy core buckling in J-PARC 3 GeV RCS

    NASA Astrophysics Data System (ADS)

    Nomura, M.; Yamamoto, M.; Schnase, A.; Shimada, T.; Suzuki, H.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.

    2010-11-01

    We have been operating ten RF cavities loaded with magnetic alloy (MA) cores with a high field gradient of more than 20 kV/m in Japan Proton Accelerator Research Complex (J-PARC) 3 GeV Rapid Cycling Synchrotron (RCS) since September 2007. During 3 years operation, we detected three times the impedance reductions of RF cavities resulting from the buckling of MA cores. To find out the origin of the MA core buckling, we evaluated the thermal stress inside the MA cores in operation and studied the relationship between the MA core buckling and core structure. We figured out that the MA core buckling was caused by the thermal stress that was enhanced due to the impregnation with low viscosity epoxy resin. We improved the MA cores without the low viscosity epoxy resin impregnation and replaced all the cores in one RF cavity with them in March 2010. Up to now we operated the RF cavity loaded with the improved MA cores for 1500 h, it showed no impedance reduction and no buckling.

  5. High density plasma calculation of J-PARC RF negative ion source

    NASA Astrophysics Data System (ADS)

    Shibata, T.; Asano, H.; Ikegami, K.; Naito, F.; Nanmo, K.; Oguri, H.; Ohkoshi, K.; Shinto, K.; Takagi, A.; Ueno, A.

    2017-08-01

    Ignition and steady state phases of Radio Frequency (RF) plasma in J-PARC ion source has been investigated by numerical modeling. The model takes into account the transport of plasma particles (electrons, protons, hydrogen molecular ions and cesium ions) in electromagnetic (EM) field with collision processes. Inductively coupled and capacitive EM fields are simultaneously solved in the model with plasma transport. Applying KEK parallel computation system A (64 cores, 56 nodes with 256 GB memory per node), behavior of high density plasma up to 1019 - 1020 m-3 in the steady state is calculated. In the simulation, it has been clarified that inductively coupled electric field in azimuthal direction and magnetic field in axial direction play a key role to maintain high density plasma which oscillates with frequency up to doubled value of applied RF frequency. The spatial distribution plot of plasma density and EM field at each phase may lead to understandings on how RF plasma is kept stable inside the source chamber.

  6. Neutron Capture Cross Section Measurement on 91Zr at J-PARC/MLF/ANNRI

    NASA Astrophysics Data System (ADS)

    Hori, Jun-ichi; Yashima, Hiroshi; Nakamura, Shoji; Furutaka, Kazuyoshi; Hara, Kaoru Y.; Harada, Hideo; Hirose, Kentaro; Igashira, Masayuki; Katabuchi, Tatsuya; Kimura, Atsushi; Kino, Koichi; Kitatani, Fumito; Kiyanagi, Yoshiaki; Koizumi, Mitsuo; Mizumoto, Motoharu; Sano, Tadafumi; Takahashi, Yoshiyuki; Toh, Yosuke

    2015-05-01

    The neutron capture cross section measurement on 91Zr was performed at neutron TOF beam line ANNRI installed at J-PARC/MLF. Prompt capture gamma rays from the sample were detected with an array of large Ge detectors at a distance of 21.5 m from the spallation neutron source by the time-of-fligh (TOF) method. The neutron capture gamma-ray pulse-height spectra from the 182-eV p-wave resonance and the 292-eV s-wave resonance were obtained by gating on the TOF regions, respectively. Though the decay patterns of primary transitions from the capture state were quite different between resonances, the prominent characteristics common to both resonances was the very strong ground-state transition from the 935-keV state. Therefore, a ground-state transition method was applied to obtain the capture yield, so that the background components due to impurities were successfully eliminated. The preliminary result of the neutron capture cross section for 91Zr up to 5 keV is presented.

  7. Probing Strong Interaction with Kaonic Atoms — from DAΦNE to J-PARC

    NASA Astrophysics Data System (ADS)

    Zmeskal, J.; Sato, M.; Bazzi, M.; Beer, G.; Berucci, C.; Bosnar, D.; Bragadireanu, M.; Buehler, P.; Cargnelli, M.; Clozza, A.; Curceanu, C.; D'uffizi, A.; Fabbietti, L.; Fiorini, C.; Ghio, F.; Golser, R.; Guaraldo, C.; Hashimoto, T.; Hayano, R. S.; Iliescu, M.; Itahashi, K.; Iwasaki, M.; Levi Sandri, P.; Marton, J.; Moskal, P.; Ohnishi, H.; Okada, S.; Outa, H.; Pietreanu, D.; Piscicchia, K.; Poli Lener, M.; Romero Vidal, A.; Sakuma, F.; Sbardella, E.; Scordo, A.; Shi, H.; Sirghi, D.; Sirghi, F.; Suzuki, K.; Tucakovic, I.; Vazquez Doce, O.; Widmann, E.

    The study of the antikaon nucleon system at very low energies plays a key role to study strong interaction with strangeness, touching one of the fundamental problems in hadron physic today — the still unsolved question of how hadron masses are generated. Exotic atoms offer a unique possibility to determine s-wave kaon-nucleon scattering lengths at vanishing energy. At the DAΦNE electron positron collider of Laboratori Nazionali di Frascati in the SIDDHARTA experiment kaonic atoms were formed with Z = 1 (K-p) and Z = 2 (K-He), which were measured with up to now unrivalled precision. This experiment is taking advantage of the low-energy charged kaons from ϕ-mesons decaying nearly at rest. Finally, using the experience gained with SIDDHARTA, a proposal to measure kaonic deuterium for the first time was submitted to J-PARC with the goal to determine the isospin dependent scattering lengths, which is only possible by combining the K-p and the upcoming K-d results.

  8. The design of the radial collimator for residual stress analysis diffractometer of J-PARC

    NASA Astrophysics Data System (ADS)

    Torii, Shuki; Moriai, Atsushi

    2006-11-01

    Radial collimators are devices needed to define gauge sizes in neutron diffraction experiments. A design work of collimators needed for an engineering diffractometer that will be built at J-PARC is being progressed. Several collimators for different gauge sizes (1, 3, 5 mm, etc …) are going to be designed to define a gauge size range from 1 to 10 mm. An equation was established to express a relation between the gauge size and geometrical design parameters of the collimator, by applying a normal distribution curve to the error distribution of measured gauge size. Currently, the geometric calculations for several collimators have been finished. A prototype collimator for a gauge size of 1 mm was made and an FWHM (full width at half maximum) of the normal distribution of 1 mm was obtained from performance tests conducted at the neutron diffractometer for residual stress analysis RESA in JRR-3 (Japan Research Reactor-3) of Japan Atomic Energy Agency (JAEA). In addition, the performance test results are in a good agreement with results from a Monte Carlo simulation with the McStas using the design parameters.

  9. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    SciTech Connect

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; Aronson, A.; Diamond, D.; Yarsky, P.

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculation pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.

  10. TRACE/PARCS Analysis of ATWS with Instability for a MELLLA+BWR/5

    DOE PAGES

    L. Y. Cheng; Baek, J. S.; Cuadra, A.; ...

    2016-06-06

    A TRACE/PARCS model has been developed to analyze anticipated transient without SCRAM (ATWS) events for a boiling water reactor (BWR) operating in the maximum extended load line limit analysis-plus (MELLLA+) expanded operating domain. The MELLLA+ domain expands allowable operation in the power/flow map of a BWR to low flow rates at high power conditions. Such operation exacerbates the likelihood of large amplitude power/flow oscillations during certain ATWS scenarios. The analysis shows that large amplitude power/flow oscillations, both core-wide and out-of-phase, arise following the establishment of natural circulation flow in the reactor pressure vessel (RPV) after the trip of the recirculationmore » pumps and an increase in core inlet subcooling. The analysis also indicates a mechanism by which the fuel may experience heat-up that could result in localized fuel damage. TRACE predicts the heat-up to occur when the cladding surface temperature exceeds the minimum stable film boiling temperature after periodic cycles of dryout and rewet; and the fuel becomes “locked” into a film boiling regime. Further, the analysis demonstrates the effectiveness of the simulated manual operator actions to suppress the instability.« less

  11. Study for s-process using neutron beam provided from ANNRI of J-PARC

    NASA Astrophysics Data System (ADS)

    Hayakawa, Takehioto; Toh, Yosuke; Kimura, Akira; Nakamura, Shoji; Shizuma, Toshiyuki; Harada, Hideo

    2016-06-01

    Most isotopes heavier than iron are synthesized by the slow neutron capture reaction process (s-process) in stars. Isomers in stable isotopes have sometimes an important role as a branching point in nucleosynthesis flow in the s-process. An isomer with a half-life of 14.1 y in 113Cd is a branching point from which a nucleosynthesis flow reaches to a rare isotope 115Sn. The astrophysical origin of 115Sn has remained still an open question. The s-process abundance of 115Sn depends on the ratio of the 112Cd(n, γ) 113Cdm reaction cross section to the 112Cd(n, γ) 113Cdgs reaction cross section. However, the isomer production ratio following the neutron capture reaction has not been measured in the energy region higher than the thermal energy. An intense neutron beam experimental system, ANNRI, in J-PARC has a high purity germanium (HPGe) detector system consisting of two cluster detectors. We have measured γ-rays decaying to the ground state and the isomer using the HPGe detectors in conjunction with a time-offlight method at ANNRI.

  12. Fluoroquinolone Resistance Mutations in the parC, parE, and gyrA Genes of Clinical Isolates of Viridans Group Streptococci

    PubMed Central

    González, Irene; Georgiou, Marios; Alcaide, Fernando; Balas, Delia; Liñares, Josefina; de la Campa, Adela G.

    1998-01-01

    The nucleotide sequences of the quinolone resistance-determining regions (QRDRs) of the parC and gyrA genes from seven ciprofloxacin-resistant (Cpr) isolates of viridans group streptococci (two high-level Cpr Streptococcus oralis and five low-level Cpr Streptococcus mitis isolates) were determined and compared with those obtained from susceptible isolates. The nucleotide sequences of the QRDRs of the parE and gyrB genes from the five low-level Cpr S. mitis isolates and from the NCTC 12261 type strain were also analyzed. Four of these low-level Cpr isolates had changes affecting the subunits of DNA topoisomerase IV: three in Ser-79 (to Phe or Ile) of ParC and one in ParE at a position not previously described to be involved in quinolone resistance (Pro-424). One isolate did not show any mutation. The two high-level Cpr S. oralis isolates showed mutations affecting equivalent residue positions of ParC and GyrA, namely, Ser-79 to Phe and Ser-81 to Phe or Tyr, respectively. The parC mutations were able to transform Streptococcus pneumoniae to ciprofloxacin resistance, while the gyrA mutations transformed S. pneumoniae only when mutations in parC were present. These results suggest that DNA topoisomerase IV is a primary target of ciprofloxacin in viridans group streptococci, DNA gyrase being a secondary target. PMID:9797205

  13. Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci.

    PubMed

    González, I; Georgiou, M; Alcaide, F; Balas, D; Liñares, J; de la Campa, A G

    1998-11-01

    The nucleotide sequences of the quinolone resistance-determining regions (QRDRs) of the parC and gyrA genes from seven ciprofloxacin-resistant (Cpr) isolates of viridans group streptococci (two high-level Cpr Streptococcus oralis and five low-level Cpr Streptococcus mitis isolates) were determined and compared with those obtained from susceptible isolates. The nucleotide sequences of the QRDRs of the parE and gyrB genes from the five low-level Cpr S. mitis isolates and from the NCTC 12261 type strain were also analyzed. Four of these low-level Cpr isolates had changes affecting the subunits of DNA topoisomerase IV: three in Ser-79 (to Phe or Ile) of ParC and one in ParE at a position not previously described to be involved in quinolone resistance (Pro-424). One isolate did not show any mutation. The two high-level Cpr S. oralis isolates showed mutations affecting equivalent residue positions of ParC and GyrA, namely, Ser-79 to Phe and Ser-81 to Phe or Tyr, respectively. The parC mutations were able to transform Streptococcus pneumoniae to ciprofloxacin resistance, while the gyrA mutations transformed S. pneumoniae only when mutations in parC were present. These results suggest that DNA topoisomerase IV is a primary target of ciprofloxacin in viridans group streptococci, DNA gyrase being a secondary target.

  14. Closeout Report - Search for Time Reversal Symmetry Violation with TREK at J-PARC

    SciTech Connect

    Kohl, Michael

    2015-04-15

    This DOE Early Career Award has enabled Dr. Michael Kohl to take on and expand his leadership roles in several projects such as TREK@J-PARC, OLYMPUS@DESY, MUSE@PSI, and in the experimental program in Hall C at Jefferson Lab. Dr. Kohl has successfully accomplished several items: (i) Preliminary results from SANE (E08-003) at Jefferson Lab: Former HU graduate student Anusha Liyanage has pursued her PhD research on SANE. Her analysis of the elastic ep scattering data has resulted in the extraction of the proton electric-to-magnetic form factor ratio from double spin asymmetries at the highest momentum transfer to date. The results are almost final and a publication is in preparation. (ii) Approval of TREK/E36 for running, preparation of simulation and analysis: the TREK experiment has been stage-II approved in fall 2013, has been mounted on the hall floor from November 2014 to April 2015, has been commissioned in April-June 2015 and is scheduled to run in fall 2015. The group has contributed significantly with simulations and magnetic field map calculations, has investigated the sensitivity of TREK to new light neutral particles, and contributed substantially to the mounting and commissioning of the experiment. (iii) Running of OLYMPUS and analysis: Under Dr. Kohl's leadership as spokesman, the OLYMPUS experiment has completed data taking beginning of 2013; calibrations and analysis have been well underway, with results to be expected in the course of 2015. (iv) Operation of GEM detectors at OLYMPUS and MUSE: The GEM telescopes built for OLYMPUS luminosity monitoring with forward-angle ep elastic scattering have been operated successfully, have meanwhile been relocated to PSI, and have been re-commissioned as beam particle trackers for the PSI secondary beams for MUSE. (v) Trained and prepared postdocs and graduate students for their future careers. Two postdocs from Dr. Kohl's group (Dr. Juergen Diefenbach and Dr. Peter Monaghan) have found permanent academic

  15. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC.

    PubMed

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-Ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-02-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm(3) in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4-4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm(3)) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research.

  16. SENJU: a new time-of-flight single-crystal neutron diffractometer at J-PARC

    PubMed Central

    Ohhara, Takashi; Kiyanagi, Ryoji; Oikawa, Kenichi; Kaneko, Koji; Kawasaki, Takuro; Tamura, Itaru; Nakao, Akiko; Hanashima, Takayasu; Munakata, Koji; Moyoshi, Taketo; Kuroda, Tetsuya; Kimura, Hiroyuki; Sakakura, Terutoshi; Lee, Chang-Hee; Takahashi, Miwako; Ohshima, Ken-ichi; Kiyotani, Tamiko; Noda, Yukio; Arai, Masatoshi

    2016-01-01

    SENJU is a new single-crystal time-of-flight neutron diffractometer installed at BL18 at the Materials and Life Science Experimental Facility of the Japan Accelerator Research Complex (J-PARC). The diffractometer was designed for precise crystal and magnetic structure analyses under multiple extreme sample environments such as low temperature, high pressure and high magnetic field, and for diffraction measurements of small single crystals down to 0.1 mm3 in volume. SENJU comprises three choppers, an elliptical shape straight supermirror guide, a vacuum sample chamber and 37 scintillator area detectors. The moderator-to-sample distance is 34.8 m, and the sample-to-detector distance is 800 mm. The wavelength of incident neutrons is 0.4–4.4 Å (first frame). Because short-wavelength neutrons are available and the large solid angle around the sample position is covered by the area detectors, a large reciprocal space can be simultaneously measured. Furthermore, the vacuum sample chamber and collimator have been designed to produce a very low background level. Thus, the measurement of a small single crystal is possible. As sample environment devices, a newly developed cryostat with a two-axis (ω and φ axes) goniometer and some extreme environment devices, e.g. a vertical-field magnet, high-temperature furnace and high-pressure cell, are available. The structure analysis of a sub-millimetre size (0.1 mm3) single organic crystal, taurine, and a magnetic structure analysis of the antiferromagnetic phase of MnF2 have been performed. These results demonstrate that SENJU can be a powerful tool to promote materials science research. PMID:26937237

  17. Mass production of the large-sized nuclear plate for J-PARC E07

    NASA Astrophysics Data System (ADS)

    Ito, Hiroki; Nakazama, Kazuma; Hoshino, Kaoru; Yoshida, Jyunya; Tint, Khin Than; Soe, Mint Kyaw; Kinbara, Shinji; Mishina, Akihiro; Endo, Yoko; Kobayashi, Hidetaka; J-PARC E07 Collaboration

    2014-09-01

    In J-PARC E07, about 102 double lambda hypernuclei will be detected, which is 10 times or more than that of the KEK PS-E373 experiment. Therefore, it is necessary for large-scale emulsion plates to avoid time-consuming job for exchange emulsion stack in beam exposure. We also use huge amount of emulsion gel with weight of 2.1 t, which is about 3 times' quantity used for E373. Nuclear emulsion plate is made of photographic emulsion gel as a dry film. Melted gel in 40°C is poured on a thin polystyrene film in the size of 710 × 700 mm2. These sheets were dried slowly for two days in drying cabinet under 28°C and RH. 75%. After drying, the surface was coated by thin gelatin layer with 0.3 μm thickness. Regarding the 2nd face, it was poured and coated in the same manner. Finally we dry it well under 25°C and RH. 60% and cut into four 350 × 345 mm2 plates. We evaluated the performance about these plates. The length of upper, lower, right-hand and left-hand side are 345.08 +/- 0.05 mm, 345.23 +/- 0.13 mm, 350.03 +/- 0.04 mm, and 350.80 +/- 0.05 mm, respectively. The density is 3.676 +/- 0.032 g/cm3, enough quality for the experiment.

  18. New Physics search with Experiment E36 at J-PARC

    NASA Astrophysics Data System (ADS)

    Dongwi, Dongwi H.; TREK Collaboration

    2017-01-01

    We are potentially standing at the precipice in the quest for discovery of New Physics (NP) beyond the SM by performing a precision test of lepton universality. Experiment E36 conducted at J-PARC in Japan tests lepton universality in the RK = Γ(Ke 2) / Γ(Kμ 2) ratio. In the SM, the ratio of leptonic K+ decays is highly precise with an uncertainty of ΔRK /RK = 4 .10-4 . Any observed deviation from the SM prediction would break the universality of the lepton couplings and provide a clear indication of NP beyond the SM. The E36 detector apparatus allows sensitivity to search for sterile neutrinos below 300 MeV/c2 and light U(1) gauge bosons, which could be associated with dark matter or explain established muon-related anomalies such as the muon g-2 value, and perhaps the proton radius puzzle. E36 data taking was completed in 2015. A scintillating fiber target was used to stop a beam of up to 1.2 Million K+ per spill. K+ decay products were detected with a large-acceptance toroidal spectrometer capable of tracking charged particles with high resolution, combined with a CsI(Tl) photon calorimeter with large solid angle covering 75 % of 4 π and particle identification systems. The status of the data analysis will be presented. This work has been supported by DOE awards DE-SC0003884 and DE-SC0013941 in the US, NSERC in Canada, and Kaken-hi in Japan.

  19. Rod-filter-field optimization of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second-stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). Although rod-filter-field (RFF) is indispensable and one of the most beam performance dominative parameters for the RF-driven H{sup −} ion source with the internal-antenna, the procedure to optimize it is not established. In order to optimize the RFF and establish the procedure, the beam performances of the J-PARC source with various types of rod-filter-magnets (RFMs) were measured. By changing RFM’s gap length and gap number inside of the region projecting the antenna inner-diameter along the beam axis, the dependence of the H{sup −} ion beam intensity on the net 2MHz-RF power was optimized. Furthermore, the fine-tuning of RFM’s cross-section (magnetmotive force) was indispensable for easy operation with the temperature (T{sub PE}) of the plasma electrode (PE) lower than 70°C, which minimizes the transverse emittances. The 5% reduction of RFM’s cross-section decreased the time-constant to recover the cesium effects after an slightly excessive cesiation on the PE from several 10 minutes to several minutes for T{sub PE} around 60°C.

  20. Analysis of the OECD/NRC BWR Turbine Trip Transient Benchmark with the Coupled Thermal-Hydraulics and Neutronics Code TRAC-M/PARCS

    SciTech Connect

    Lee, Deokjung; Downar, Thomas J.; Ulses, Anthony; Akdeniz, Bedirhan; Ivanov, Kostadin N.

    2004-10-15

    An analysis of the Peach Bottom Unit 2 Turbine Trip 2 (TT2) experiment has been performed using the U.S. Nuclear Regulatory Commission coupled thermal-hydraulics and neutronics code TRAC-M/PARCS. The objective of the analysis was to assess the performance of TRAC-M/PARCS on a BWR transient with significance in two-phase flow and spatial variations of the neutron flux. TRAC-M/PARCS results are found to be in good agreement with measured plant data for both steady-state and transient phases of the benchmark. Additional analyses of four fictitious extreme scenarios are performed to provide a basis for code-to-code comparisons and comprehensive testing of the thermal-hydraulics/neutronics coupling. The obtained results of sensitivity studies on the effect of direct moderator heating on transient simulation indicate the importance of this modeling aspect.

  1. PARC - Scientific Exchange Program (A "Life at the Frontiers of Energy Research" contest entry from the 2011 Energy Frontier Research Centers (EFRCs) Summit and Forum)

    ScienceCinema

    Blankenship, Robert E. (Director, Photosynthetic Antenna Research Center); PARC Staff

    2016-07-12

    'PARC - Scientific Exchange Program' was submitted by the Photosynthetic Antenna Research Center (PARC) to the 'Life at the Frontiers of Energy Research' video contest at the 2011 Science for Our Nation's Energy Future: Energy Frontier Research Centers (EFRCs) Summit and Forum. Twenty-six EFRCs created short videos to highlight their mission and their work. PARC, an EFRC directed by Robert E. Blankenship at Washington University in St. Louis, is a partnership of scientists from ten institutions. The Office of Basic Energy Sciences in the U.S. Department of Energy's Office of Science established the 46 Energy Frontier Research Centers (EFRCs) in 2009. These collaboratively-organized centers conduct fundamental research focused on 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The overall purpose is to accelerate scientific progress toward meeting the nation's critical energy challenges.

  2. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

    NASA Astrophysics Data System (ADS)

    Shibata, T.; Nishida, K.; Mochizuki, S.; Mattei, S.; Lettry, J.; Hatayama, A.; Ueno, A.; Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Naito, F.

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  3. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source.

    PubMed

    Shibata, T; Nishida, K; Mochizuki, S; Mattei, S; Lettry, J; Hatayama, A; Ueno, A; Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Naito, F

    2016-02-01

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30-120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  4. DESIGN OF SUPERCONDUCTING COMBINED FUNCTION MAGNETS FOR THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    WANDERER,P.; ET AL.

    2003-06-15

    Superconducting combined function magnets will be utilized for the 50GeV-750kW proton beam line for the J-PARC neutrino experiment and an R and D program has been launched at KEK. The magnet is designed to provide a combined function with a dipole field of 2.59 T and a quadrupole field of 18.7 T/m in a coil aperture of 173.4 mm. A single layer coil is proposed to reduce the fabrication cost and the coil arrangement in the 2-D cross-section results in left-right asymmetry. This paper reports the design study of the magnet.

  5. Numerical study of plasma generation process and internal antenna heat loadings in J-PARC RF negative ion source

    SciTech Connect

    Shibata, T. Ueno, A.; Oguri, H.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Naito, F.; Nishida, K.; Mochizuki, S.; Hatayama, A.; Mattei, S.; Lettry, J.

    2016-02-15

    A numerical model of plasma transport and electromagnetic field in the J-PARC (Japan Proton Accelerator Research Complex) radio frequency ion source has been developed to understand the relation between antenna coil heat loadings and plasma production/transport processes. From the calculation, the local plasma density increase is observed in the region close to the antenna coil. Electrons are magnetized by the magnetic field line with absolute magnetic flux density 30–120 Gauss which leads to high local ionization rate. The results suggest that modification of magnetic configuration can be made to reduce plasma heat flux onto the antenna.

  6. The design and basic performance of a Spiral Fiber Tracker for the J-PARC E36 experiment

    NASA Astrophysics Data System (ADS)

    Mineev, O.; Bianchin, S.; Hasinoff, M. D.; Horie, K.; Igarashi, Y.; Imazato, J.; Ito, H.; Kawai, H.; Kodama, S.; Kohl, M.; Kudenko, Yu.; Shimizu, S.; Tabata, M.; Toyoda, A.; Yershov, N.

    2017-03-01

    A spiral fiber tracker (SFT) has been designed and produced for the J-PARC E36 experiment as an element of the tracking system for conducting a high-resolution momentum measurement of charged particles from kaon decays. A novel technique to wind the pre-made fiber ribbons spirally was employed for the configuration with four detector layers made of 1 mm diameter plastic scintillating fibers. Good position alignment and sufficiently high detection efficiency for charged particles with minimum ionizing energy were confirmed in cosmic ray test. The tracker was successfully used in the E36 experiment.

  7. Studies of high density baryon matter with high intensity heavy-ion beams at J-PARC

    NASA Astrophysics Data System (ADS)

    Sako, H.; Harada, H.; Sakaguchi, T.; Chujo, T.; Esumi, S.; Gunji, T.; Hasegawa, S.; Hwang, S. H.; Ichikawa, Y.; Imai, K.; Itakura, K.; Kaneta, M.; Kim, B. C.; Kinsho, M.; Kitazawa, M.; Liu, Y.; Masui, H.; Nagamiya, S.; Nishio, K.; Okamura, M.; Oyama, K.; Ozawa, K.; Saha, P. K.; Sakaguchi, A.; Sato, S.; Shigaki, K.; Sugimura, H.; Tanida, K.; Tamura, J.; Tamura, H.; Nara, Y.; Saito, T. R.

    2016-12-01

    In J-PARC heavy-ion project, we aim at studies of QCD phase structures and hadron properties in high baryon density close to the neutron star core. We have developed a heavy-ion acceleration scheme with a new linac and a new booster with existing two synchrotrons with the goal beam rate of about 1011 Hz. We have also designed a large acceptance spectrometer based on a toroidal magnet. We have evaluated the spectrometer performance, and demonstrated reconstructing dielectron and dimuon spectra with full detector simulations. Finally, we designed a hypernuclear spectrometer which can utilize the full intensity ion beams.

  8. Susceptibilities of Neisseria gonorrhoeae Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics

    PubMed Central

    Tanaka, Masatoshi; Nakayama, Hiroshi; Haraoka, Masashi; Saika, Takeshi; Kobayashi, Intetsu; Naito, Seiji

    2000-01-01

    We examined the antimicrobial susceptibilities of 85 Neisseria gonorrhoeae isolates, classified according to the presence of amino acid substitutions in the GyrA and ParC proteins, to 12 fluoroquinolones and 7 other antibiotics. Sitafloxacin and HSR-903 showed excellent activity against N. gonorrhoeae, including strains with both GyrA and ParC substitutions. Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated β-lactams. PMID:10602748

  9. Emittance measurements for optimum operation of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The transverse emittances of the source were measured with various conditions to find out the optimum operation conditions minimizing the horizontal and vertical rms normalized emittances. The transverse emittances were most effectively reduced by operating the source with the plasma electrode temperature lower than 70°C. The optimum value of the cesium (Cs) density around the beam hole of the plasma electrode seems to be proportional to the plasma electrode temperature. The fine control of the Cs density is indispensable, since the emittances seem to increase proportionally to the excessiveness of the Cs density. Furthermore, the source should be operated with the Cs density beyond a threshold value, since the plasma meniscus shape and the ellipse parameters of the transverse emittances seem to be changed step-function-likely on the threshold Cs value.

  10. Tuning of RF amplitude and phase for the separate-type drift tube linac in J-PARC

    NASA Astrophysics Data System (ADS)

    Shen, Guobao; Ikegami, Masanori

    2009-01-01

    It is important to accurately adjust the amplitude and the phase of RF power sources for a high intensity proton linac. J-PARC (Japan proton accelerator research complex) linac is one of those high-intensity linacs. J-PARC linac has 30 SDTL (separate-type drift tube linac) tanks to accelerate the negative hydrogen ions from 50 to 181 MeV. Two neighboring SDTL tanks are driven by one klystron, where the phase and the amplitude of these two tanks are controlled in terms of the vector sum. The target-value of the vector sum control should be determined with a beam-based tuning for each klystron. During the beam commissioning, the RF tuning has been performed with a phase scan method introducing a concept of phase signature matching. In the tuning, the output beam energy from the SDTL module is monitored while scanning the RF phase. Comparing the obtained phase dependence of the output beam energy with those from a numerical model, the target-values for the low-level RF control system has been tuned within the required accuracy of 1° in phase and 1% in amplitude. The same tuning procedure has successfully been applied to the RF tuning of buncher and debuncher cavities.

  11. High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

    PubMed Central

    Janoir, C; Zeller, V; Kitzis, M D; Moreau, N J; Gutmann, L

    1996-01-01

    The mechanism of high-level fluoroquinolone resistance was studied in strains of Streptococcus pneumoniae, either selected in vitro or isolated from clinical samples. By using DNA from these high-level-resistant strains, low-level-resistant transformants (MIC of pefloxacin, > or = 32 micrograms/ml; MIC of ciprofloxacin, 4 micrograms/ml; MIC of sparfloxacin, 0.50 micrograms/ml) were obtained at high frequencies (ca.10(-2)), while high-level-resistant transformants (MIC of pefloxacin, > or = 64 micrograms/ml; MIC of ciprofloxacin, 16 to 64 micrograms/ml; MIC of sparfloxacin, > or = 8 micrograms/ml) were obtained only at low frequencies (ca.10(-4)). This suggested that mutations in at least two unlinked genes were necessary to obtain high-level resistance. Low-level resistance was associated with ParC mutations (change from Ser to Tyr at position 79 [Ser79Tyr], Ser79Phe, or Asp83Gly). ParC mutations were associated, in high-level-resistant strains and transformants, with alterations in the quinolone resistance-determining region of GyrA (Ser84Tyr, Ser84Phe, and/or Glu88Lys). Low-level resistance was shown to be necessary for expression of the gyrA mutations. No mutation in the region corresponding to the quinolone resistance-determining region of GyrB and no alteration of drug accumulation were found. PMID:9124836

  12. Λ*-p Structure of K-pp and Theoretical Analysis on Recent Data from J-PARC

    NASA Astrophysics Data System (ADS)

    Phyo, Wai Mu Mu; Swe Myint, Khin; Akaishi, Yoshinori; Yamazaki, Toshimitsu

    In recent years, missing mass spectra of 3He(K-, n)X and D(π+, K+)X reactions have been used in search for the simplest anti-kaonic nuclear system, K-pp, at J-PARC E15 and E27 experiments, respectively. We have conducted theoretical interpretations of these inclusive mass spectra, on the basis of Λ*-p structure of K-pp, where Λ* = Λ(1405) is first formed as a doorway to K-pp. We have investigated carefully the mass region of spectra covering quasi-free Λ* production and K-pp formation. Furthermore, a new experiment measuring the invariant-mass spectrum of D(K-, n)πΣ, is planned at J-PARC E31 experiment in order to clarify the production of Λ(1405). We have studied the formation mechanism of Λ* in this reaction, which provides useful information on quasi-free Λ* excitation in the E15 spectrum. It is noted that due to formation weights of Λ* inside the target nucleus, the spectrum peak positions are shifted upwards from the original Λ(1405) pole position on the order of 10-15 MeV in the E15 and E31 spectra. We claim that 30 MeV shift of QF Λ* peak in E27 experiment is partly accounted for by the strength of a Λ*p interaction which is constructed based on DISTO experimental data.

  13. Horizontal Transfer of parC and gyrA in Fluoroquinolone-Resistant Clinical Isolates of Streptococcus pneumoniae

    PubMed Central

    Ferrándiz, María José; Fenoll, Asunción; Liñares, Josefina; De La Campa, Adela G.

    2000-01-01

    We have analyzed genetically three clinical isolates (3180, 3870, and 1244) of Streptococcus pneumoniae with high-level ciprofloxacin resistance. Isolates 3180 and 3870 were atypical because of their insolubility in deoxycholate. However, they hybridized specifically with pneumococcal autolysin and pneumolysin gene probes and have typical pneumococcal atpC and atpA gene sequences. Analysis of the complete sequences of the parC and gyrA genes revealed total variations of 8 and 8.7% (isolate 3180) and 7.4 and 3.6% (isolate 3870), respectively, compared to the wild-type strain R6 sequence. The variations observed between the sequences of R6 and isolate 1244 were less than 0.9%. The structure of the gyrA and parC genes from isolates 3180 and 3870 was organized in sequence blocks that show different levels of divergence, suggesting a pattern of recombination. These results are evidence for recombination at the fluoroquinolone target genes in clinical isolates of S. pneumoniae. The genetically related viridans group streptococci could act as a reservoir for fluoroquinolone resistance genes. PMID:10722479

  14. Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae.

    PubMed

    Ferrándiz, M J; Fenoll, A; Liñares, J; De La Campa, A G

    2000-04-01

    We have analyzed genetically three clinical isolates (3180, 3870, and 1244) of Streptococcus pneumoniae with high-level ciprofloxacin resistance. Isolates 3180 and 3870 were atypical because of their insolubility in deoxycholate. However, they hybridized specifically with pneumococcal autolysin and pneumolysin gene probes and have typical pneumococcal atpC and atpA gene sequences. Analysis of the complete sequences of the parC and gyrA genes revealed total variations of 8 and 8.7% (isolate 3180) and 7.4 and 3.6% (isolate 3870), respectively, compared to the wild-type strain R6 sequence. The variations observed between the sequences of R6 and isolate 1244 were less than 0.9%. The structure of the gyrA and parC genes from isolates 3180 and 3870 was organized in sequence blocks that show different levels of divergence, suggesting a pattern of recombination. These results are evidence for recombination at the fluoroquinolone target genes in clinical isolates of S. pneumoniae. The genetically related viridans group streptococci could act as a reservoir for fluoroquinolone resistance genes.

  15. The low energy muon beam profile monitor for the muon g‑2/EDM experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Razuvaev, G. P.; Bae, S.; Choi, H.; Choi, S.; Ko, H. S.; Kim, B.; Kitamura, R.; Mibe, T.; Otani, M.

    2017-09-01

    The muon g‑2/EDM experiment at J-PARC aims to measure the muon anomalous magnetic moment and electric dipole moment with high precision by utilising an ultracold muon beam. The current muon g‑2 discrepancy between the Standard Model prediction and the experimental value is about 3.5 standard deviations. This experiment requires a development of the muon LINAC to accelerate thermal muons to the 300 MeV/c momentum. Detectors for beam diagnostics play a key role in such an experiment. The beam profile monitoring system has been designed to measure the profile of the low energy muon beam. It was tested during two beam tests in 2016 at the MLF D2 line at J-PARC. The detector was used with positive muons, Mu-(μ+ e‑ e‑), p and H-, e‑ and UV light. The system overview and preliminary results are given. Special attention is paid to the spatial resolution of the beam profile monitor and online monitor software used during data taking.

  16. High-pressure beamline (PLANET) at the spallation neutron source, J-PARC (Invited)

    NASA Astrophysics Data System (ADS)

    Kagi, H.; Hattori, T.; Arima, H.; Utsumi, W. S.; Komatsu, K.; Nagai, T.; Yagi, T.

    2009-12-01

    Material and Life Science experimental Facility (MLF) of Japan Proton Accelerator Research Complex (J-PARC) will be one of the most powerful spallation neutron facilities in the world. The pulsed neutron source with a liquid Hg target is designed to be running at 25 Hz with a power of 1 MW. We have started the construction of the powder diffractometer dedicated to high-pressure experiments (PLANET) on BL-11. PLANET aims to study structures of hydrogen-bearing materials including dense hydrous minerals of the Earth’s deep interior, magmas and light element liquids. The instrument will realize diffraction and radiography experiments for powder and liquid/glass samples at high pressures up to 20 GPa and 2000 K using a large sized multi-anvil hydraulic press that can apply forces of ˜1500 ton. The instrument views a decoupled liquid H2 moderator with a cross section of 100 × 100 mm2. The primary and secondary fight paths are 25 m and 1.5 m, respectively. The 11.5-m-long supermirror guide with elliptical shape starts at a distance of 11.5 m from the moderator. Design of elliptical geometry is optimized by means of incorporating several different grade mirrors and linear approximation with planar guide in order to save cost for production without degradation of the intensity performance. The guide has a rectangular cross-section and consists of four walls coated with supermirror material. Sample is placed at 2 m from the guide exit. The 90° detectors will be installed at 1.5 m from the sample position. For the powder diffraction measurements using a multi-anvil press, an incident neutron beam passes through the vertical anvil gaps and irradiates the sample in the pressure medium. Diffracted neutrons go through the other anvil gaps at 90° direction. Half inch 3He linear position sensitive detectors with 600 mm length will be arranged horizontally and form these detector banks, which cover the scattering angle of 79° ≤ 2θ ≤ 101° and -35° ≤ Φ ≤ +35°. The

  17. New Real-Time PCR Assay Using Locked Nucleic Acid Probes To Assess Prevalence of ParC Mutations in Fluoroquinolone-Susceptible Streptococcus pneumoniae Isolates from France

    PubMed Central

    Decousser, Jean-Winoc; Methlouthi, Imen; Pina, Patrick; Collignon, Anne; Allouch, Pierre

    2006-01-01

    A real-time PCR assay with locked nucleic acid probes was developed to screen mutations at codons 79 and 83 of the Streptococcus pneumoniae parC gene. Only silent mutations were detected among 236 French invasive fluoroquinolone-susceptible strains. This test could be useful for some high-risk patients or in national surveys. PMID:16569894

  18. Mutations in the gyrB, parC, and parE genes of quinolone-resistant isolates and mutants of Edwardsiella tarda.

    PubMed

    Kim, Myoung Sug; Jun, Lyu Jin; Shin, Soon Bum; Park, Myoung Ae; Jung, Sung Hee; Kim, Kwangil; Moon, Kyung Ho; Jeong, Hyun Do

    2010-12-01

    The full length genes gyrB (2,415 bp), parC (2,277 bp), and parE (1,896 bp) in Edwardsiella tarda were cloned by PCR with degenerate primers based on the sequence of the respective quinolone resistance-determining region (QRDR), followed by elongation of 5' and 3' ends using cassette ligation-mediated PCR (CLMP). Analysis of the cloned genes revealed open reading frames (ORFs) encoding proteins of 804 (GyrB), 758 (ParC), and 631 (ParE) amino acids with conserved gyrase/topoisomerase features and motifs important for enzymatic function. The ORFs were preceded by putative promoters, ribosome binding sites, and inverted repeats with the potential to form cruciform structures for binding of DNA-binding proteins. When comparing the deduced amino acid sequences of E. tarda GyrB, ParC, and ParE with those of the corresponding proteins in other bacteria, they were found to be most closely related to Escherichia coli GyrB (87.6% identity), Klebsiella pneumoniae ParC (78.8% identity) and Salmonella typhimurium ParE (89.5% identity), respectively. The two topoisomerase genes, parC and parE, were found to be contiguous on the E. tarda chromosome. All 18 quinoloneresistant isolates obtained from Korea thus far did not contain subunit alternations apart from a substitution in GyrA (Ser83→Arg). However, an alteration in the QRDR of ParC (Ser84→Ile) following an amino acid substitution in GyrA (Asp87→Gly) was detected in E. tarda mutants selected in vitro at 8 microng/ml ciprofloxacin (CIP). A mutant with a GyrB (Ser464→Leu) and GyrA (Asp87→Gly) substitution did not show a significant increase in the minimum inhibitory concentration (MIC) of CIP. None of the in vitro mutants exhibited mutations in parE. Thus, gyrA and parC should be considered to be the primary and secondary targets, respectively, of quinolones in E. tarda.

  19. Mars14 Monte Carlo simulation for the shielding studies of the J-PARC 3 GeV ring.

    PubMed

    Nakao, Noriaki; Mokhov, Nikolai; Yamamoto, Kazami; Irie, Yoshiro; Drozhdin, Alexander

    2005-01-01

    MARS14 Monte Carlo simulations were performed for collimation and shielding studies of the J-PARC 3 GeV synchrotron ring. The beam line module locations in the 348.3 m ring and the curved tunnel sections were described by the 'MAD-MARS beam line builder' tool. A 400 MeV proton beam loss distribution, calculated with the STRUCT code, was used as a 4 kW source term in the collimator region, with 1 kW source terms in the injection and extraction regions at 400 MeV and 3 GeV, respectively. Deep penetration calculations were carried out with good statistics using a newly developed three-dimensional multi-layer technique. Prompt dose-rate distributions were calculated inside and outside the concrete and soil shield up to the ground level. Using the calculation results obtained thus, an effective shielding design was made.

  20. Monitoring System for the Gold Target by Radiation Detectors in Hadron Experimental Facility at J-PARC

    NASA Astrophysics Data System (ADS)

    Muto, Ryotaro; Agari, Keizo; Aoki, Kazuya; Bessho, Kotaro; Hagiwara, Masayuki; Hirose, Erina; Ieiri, Masaharu; Iwasaki, Ruri; Katoh, Yohji; Kitagawa, Jun-ichi; Minakawa, Michifumi; Morino, Yuhei; Saito, Kiwamu; Sato, Yoshinori; Sawada, Shin'ya; Shirakabe, Yoshihisa; Suzuki, Yoshihiro; Takahashi, Hitoshi; Tanaka, Kazuhiro; Toyoda, Akihisa; Watanabe, Hiroaki; Yamanoi, Yutaka

    2017-09-01

    At the Hadron Experimental Facility in J-PARC, we inject a 30-GeV proton beam into a gold target to produce secondary particle beams required for various particle and nuclear physics experiments. The gold target is placed in a hermetic chamber, and helium gas is circulated in the chamber to monitor the soundness of the target. The radioactivity in helium gas is continuously monitored by gamma-ray detectors such as a germanium detector and a NaI(Tl) detector. Beam operations with those target-monitoring systems were successfully performed from April to June and October to December 2015, and from May to June 2016. In this paper, the details of the helium gas circulation system and gamma-ray detectors and the analysis results of the obtained gamma-ray spectra are reported.

  1. Current status of a time-of-flight single crystal neutron diffractometer SENJU at J-PARC

    NASA Astrophysics Data System (ADS)

    Tamura, I.; Oikawa, K.; Kawasaki, T.; Ohhara, T.; Kaneko, K.; Kiyanagi, R.; Kimura, H.; Takahashi, M.; Kiyotani, T.; Arai, M.; Noda, Y.; Ohshima, K.

    2012-02-01

    SENJU is a state-of-the-art single crystal time-of-flight Laue diffractometer in Materials and Life Science Experimental Facility at Japan Proton Accelerator Research Complex (J-PARC). The diffractometer is designed for precise crystal and magnetic structure analyses under multiple extreme conditions, such as low temperature, high-pressure, high-magnetic field. Measurements using small sample less than 1.0 mm3 will be also realized, which allows us to study wide variety of materials. SENJU is using a poisoned decoupled moderator to obtain peak profiles of Bragg reflection, and intensity distributions of superlattice reflections and diffuse scatterings with good accuracy. At the beginning, the diffractometer will have 31 two-dimensional scintillator detectors to cover wide area of reciprocal lattice space by a single measurement. The instrument is currently under construction and is scheduled to start on-beam commissioning in February 2012.

  2. New experiment at J-PARC to measure the muon neutrino cross section ratio between water and hydrocarbon

    NASA Astrophysics Data System (ADS)

    Kin, K.; Harada, J.; Seiya, Y.; Yamamoto, K.; WAGASCI Collaboration

    2017-09-01

    A new experiment, named WAGASCI can precisely measure the ratio of muon neutrino cross sections between water and hydrocarbon for charged-current interactions with a large angular acceptance at J-PARC. A new detector mainly consists of two water target modules and two hydrocarbon target modules. Each module is composed of scintillators aligned in a 3D grid-like structure having almost 4π solid angle acceptance. Each scintillator has a groove for a WLS fiber to be put on, and they are glued with the optical cement by using a semi-automated gluing system. WLS fibers are connected to Multi-Pixel Photon Counters (MPPCs), which are crosstalk suppression type. The detector is now under construction, and we will start taking the data in 2017.

  3. SUPERCONDUCTING MAGNET SYSTEM AT THE 50 GEV PROTON BEAM LINE FOR THE J-PARC NEUTRINO EXPERIMENT.

    SciTech Connect

    WANDERER,P.; ET AL.

    2003-06-15

    A neutrino oscillation experiment using the J-PARC SO GeV 0.75 MW proton beam is planned as a successor to the K2K project currently being operated at KEK. A superconducting magnet system is required for the arc section of the primary proton beam line to be within the space available at the site. A system with 28 combined function magnets is proposed to simplify the system and optimize the cost. The required fields for the magnets are 2.6 T dipole and 19 T/m quadrupole. The magnets are also required to have a large aperture, 173.4 mm diameter, to accommodate the large beam emittance. The magnets will be protected by cold diodes and cooled by forced flow supercritical helium produced by a 4.5 K, 2 {approx} 2.5 kW refrigerator. This paper reports the system overview and the design status.

  4. Capture Cross-section Measurement of 241Am(n,γ) at J-PARC/MLF/ANNRI

    NASA Astrophysics Data System (ADS)

    Harada, H.; Ohta, M.; Kimura, A.; Furutaka, K.; Hirose, K.; Hara, K. Y.; Kin, T.; Kitatani, F.; Koizumi, M.; Nakamura, S.; Oshima, M.; Toh, Y.; Igashira, M.; Katabuchi, T.; Mizumoto, M.; Kino, K.; Kiyanagi, Y.; Fujii, T.; Fukutani, S.; Hori, J.; Takamiya, K.

    2014-05-01

    The 241Am(n, γ) 242Am cross sections have been measured for neutron energies between 0.01 and 10 eV using the Accurate Neutron-Nucleus Reaction measurement Instrument (ANNRI) installed at the Materials and Life-science experimental Facility (MLF) in J-PARC. ANNRI combines the strongest neutron-pulsed beam and a high energy resolution γ-ray spectrometer, making possible accurate measurements of neutron capture cross sections for highly radioactive samples. From the measured cross section, the Westcott neutron capture factor and strength of the first three resonances in 241Am are deduced. These results with precision less than 0.5 % are compared with those derived from JENDL-4.0.

  5. Cryogenic System for J-Parc Neutrino Superconducting Magnet Beam LINE—DESIGN, Construction and Performance Test

    NASA Astrophysics Data System (ADS)

    Makida, Y.; Ohhata, H.; Okamura, T.; Suzuki, S.; Araoka, O.; Ogitsu, T.; Kimura, N.; Nakamoto, T.; Sasaki, K.; Kaneda, S.; Takahashi, T.; Ito, A.; Nagami, M.; Kumaki, T.; Nakashima, T.

    2010-04-01

    A helium cryogenic plant has been constructed in the proton accelerator research complex, J-PARC, to cool a string of superconducting magnets in the neutrino beam line since 2005. It consists of a screw compressor with a capacity of 160 g/s at 1.4 MPa, a 1.5 kW refrigerator, a centrifugal SHE pump with a flow rate of 300 g/s and peripherals. After system integration, performance tests have been carried out. In a preliminary cooling test without magnets, the cryogenic system attained a cooling capacity of 522 W by circulating supercritical helium flow of 300 g/s at 0.4 MPa and at 4.5 K. Afterwards a full system test with the magnets was carried out. The magnets were successfully charged up to an ultimate current of 5000 A beyond a nominal current of 4400 A. This paper describes the plant design and the result of performance measurements.

  6. Vacuum tube operation analysis under multi-harmonic driving and heavy beam loading effect in J-PARC RCS

    NASA Astrophysics Data System (ADS)

    Yamamoto, M.; Nomura, M.; Shimada, T.; Tamura, F.; Hara, K.; Hasegawa, K.; Ohmori, C.; Toda, M.; Yoshii, M.; Schnase, A.

    2016-11-01

    An rf cavity in the J-PARC RCS not only covers the frequency range of a fundamental acceleration pattern but also generates multi-harmonic rf voltage because it has a broadband impedance. However, analyzing the vacuum tube operation in the case of multi-harmonics is very complicated because many variables must be solved in a self-consistent manner. We developed a method to analyze the vacuum tube operation using a well-known formula and which includes the dependence on anode current for some variables. The calculation method is verified with beam tests, and the results indicate that it is efficient under condition of multi-harmonics with a heavy beam loading effect.

  7. High-power test of annular-ring coupled structures for the J-PARC linac energy upgrade

    NASA Astrophysics Data System (ADS)

    Tamura, Jun; Ao, Hiroyuki; Nemoto, Yasuo; Asano, Hiroyuki; Suzuki, Takahiro

    2015-02-01

    Annular-ring coupled structures (ACSs) will increase the beam energy of the Japan proton accelerator research complex (J-PARC) linac from 181 to 400 MeV to achieve a beam power of 1 MW for a materials and life science experimental facility. The mass production of the ACS cavities commenced in March 2009. Before the installation, all cavities require power testing. High-power testing is essential not only for confirming the cavity's design performance but also for preventing delays in cavity conditioning schedule. However, the 2011 Tohoku earthquake damaged J-PARC facilities, including the ACS power-test area, and cavity conditioning was interrupted for two years. After the facility's restoration, two ACS cavities (M01 and M11) were conditioned. They performed 15-20% above the designed accelerating field of 4.2 MV/m. As M01 was initially conditioned six years ago, the most recent conditioning time required for M01 was drastically reduced. From this result, we confirmed that long-term stored ACS cavities purged with nitrogen gas do not produce critical cavity performance issues. During high-power operation of M11, which is a unique cavity equipped with a capacitive iris in a waveguide, no significant increases in the temperature and the discharge rate around the capacitive iris were observed. Even considering beam loss due to residual gas scattering, the vacuum pressure was sufficiently low (4 × 10-6 Pa). More stable operation can be expected following a month-long conditioning process before the beam is commissioned. M11's conditioning successfully demonstrated an auto-conditioning program, and we established the conditioning scheme using this auto-conditioning program for all ACS cavities in a limited time and with limited manpower.

  8. Safety Related Investigations of the VVER-1000 Reactor Type by the Coupled Code System TRACE/PARCS

    NASA Astrophysics Data System (ADS)

    Jaeger, Wadim; Espinoza, Victor Hugo Sánchez; Lischke, Wolfgang

    This study was performed at the Institute of Reactor Safety at the Forschungszentrum Karlsruhe. It is embedded in the ongoing investigations of the international code assessment and maintenance program (CAMP) for qualification and validation of system codes like TRACE(1) and PARCS(2). The chosen reactor type used to validate these two codes was the Russian designed VVER-1000 because the OECD/NEA VVER-1000 Coolant Transient Benchmark Phase 2(3) includes detailed information of the Bulgarian nuclear power plant (NPP) Kozloduy unit 6. The post-test investigations of a coolant mixing experiment have shown that the predicted parameters (coolant temperature, pressure drop, etc.) are in good agreement with the measured data. The coolant mixing pattern, especially in the downcomer, has been also reproduced quiet well by TRACE. The coupled code system TRACE/PARCS which was applied on a postulated main steam line break (MSLB) provided good results compared to reference values and the ones of other participants of the benchmark. The results show that the developed three-dimensional nodalization of the reactor pressure vessel (RPV) is appropriate to describe the coolant mixing phenomena in the downcomer and the lower plenum of a VVER-1000 reactor. This phenomenon is a key issue for investigations of MSLB transient where the thermal hydraulics and the core neutronics are strongly linked. The simulation of the RPV and core behavior for postulated transients using the validated 3D TRACE RPV model, taking into account boundary conditions at vessel in- and outlet, indicates that the results are physically sound and in good agreement to other participant's results.

  9. Accessing proton generalized parton distributions and pion distribution amplitudes with the exclusive pion-induced Drell-Yan process at J-PARC

    NASA Astrophysics Data System (ADS)

    Sawada, Takahiro; Chang, Wen-Chen; Kumano, Shunzo; Peng, Jen-Chieh; Sawada, Shinya; Tanaka, Kazuhiro

    2016-06-01

    Generalized parton distributions (GPDs) encoding multidimensional information of hadron partonic structure appear as the building blocks in a factorized description of hard exclusive reactions. The nucleon GPDs have been accessed by deeply virtual Compton scattering and deeply virtual meson production with lepton beam. A complementary probe with hadron beam is the exclusive pion-induced Drell-Yan process. In this paper, we discuss recent theoretical advances on describing this process in terms of nucleon GPDs and pion distribution amplitudes. Furthermore, we address the feasibility of measuring the exclusive pion-induced Drell-Yan process π-p →μ+μ-n via a spectrometer at the High Momentum Beamline being constructed at J-PARC in Japan. Realization of such measurement at J-PARC will provide a new test of perturbative QCD descriptions of a novel class of hard exclusive reactions. It will also offer the possibility of experimentally accessing nucleon GPDs at large timelike virtuality.

  10. Pre-conditioning procedure suitable for internal-RF-antenna of J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Oguri, H.

    2016-02-15

    The Japan Proton Accelerator Research Complex (J-PARC) cesiated RF-driven H{sup −} ion source has been successfully operated for about 1 yr. By the world brightest level beam, the J-PARC design beam power of 1 MW was successfully demonstrated. Although no internal-RF-antenna failure, except for the once caused by an excess cesium due to a misoperation, occurred in the operation, many antennas failed in pre-conditionings for the first hundred days. The antenna failure rate was drastically decreased by using an antenna with coating thicker than a standard value and the pre-conditioning procedure repeating 15 min 25 kW RF-power operation and impurity-gas evacuation a few times, before the full power (50 kW) operation.

  11. Study of the bar{K}-Nucleus Interaction by Using the 12C(K-, p) Reaction at J-PARC

    NASA Astrophysics Data System (ADS)

    Ichikawa, Yudai; Ahn, Jung Keun; Akazawa, Yuya; Aoki, Kanae; Botta, Elena; Ekawa, Hiroyuki; Evtoukhovitch, Petr; Feliciello, Alessandro; Fujita, Manami; Gogami, Toshiyuki; Hasegawa, Shoichi; Hasegawa, Tomoyuki; Hayakawa, Shuhei; Hayakawa, Tomonori; Honda, Ryotaro; Hosomi, Kenji; Imai, Ken'ichi; Jung, Wooseung; Kanatsuki, Shunsuke; Kim, Shinhyung; Kinbara, Shinji; Kobayashi, Kazuya; Lee, Jaeyong; Marcello, Simonetta; Miwa, Koji; Moon, Taejin; Nagae, Tomofumi; Nakada, Yoshiyuki; Nakagawa, Manami; Nanamura, Takuya; Naruki, Megumi; Sakaguchi, Atsushi; Sako, Hiroyuki; Sato, Susumu; Sasaki, Yuki; Shirotori, Kotaro; Sugimura, Hitoshi; Takahashi, Toshiyuki; Tamura, Hirokazu; Tanida, Kiyoshi; Tsamalaidze, Zviadi; Ukai, Mifuyu; Yamamoto, Takeshi. O.

    We have measured the inclusive missing-mass spectrum of the 12C(K-, p) reaction at a K- beam momentum of 1.8 GeV/c. This experiment was carried out as a by-product of a pilot run of the J-PARC E05 experiment, which was conceived to search Ξ-hypernuclei by using the (K-, K+) reaction at J-PARC K1.8 beam line. In present measurement, we study the bar{K}-nucleus interaction by comparing the observed missing-mass spectrum with a DWIA calculation. In a preliminary analysis, a "KINK" structure, which might be originated from the threshold of K-N → Σπ absorption, was found.

  12. Validation of the U.S. NRC coupled code system TRITON/TRACE/PARCS with the special power excursion reactor test III (SPERT III)

    SciTech Connect

    Wang, R. C.; Xu, Y.; Downar, T.; Hudson, N.

    2012-07-01

    The Special Power Excursion Reactor Test III (SPERT III) was a series of reactivity insertion experiments conducted in the 1950's. This paper describes the validation of the U.S. NRC Coupled Code system TRITON/PARCS/TRACE to simulate reactivity insertion accidents (RIA) by using several of the SPERT III tests. The work here used the SPERT III E-core configuration tests in which the RIA was initiated by ejecting a control rod. The resulting super-prompt reactivity excursion and negative reactivity feedback produced the familiar bell shaped power increase and decrease. The energy deposition during such a power peak has important safety consequences and provides validation basis for core coupled multi-physics codes. The transients of five separate tests are used to benchmark the PARCS/TRACE coupled code. The models were thoroughly validated using the original experiment documentation. (authors)

  13. Relationship between mutations in parC and gyrA of clinical isolates of Streptococcus pneumoniae and resistance to ciprofloxacin and grepafloxacin.

    PubMed

    Stewart, B A; Johnson, A P; Woodford, N

    1999-12-01

    The mechanisms of resistance to ciprofloxacin and grepafloxacin were studied in 54 clinical isolates of Streptococcus pneumoniae. Restriction fragment length polymorphism analysis following HinfI digestion was used with DNA sequencing to identify mutations in the quinolone resistance-determining regions (QRDRs) of the parC and gyrA genes. Ciprofloxacin MICs up to 16 mg/L were not associated with mutations to these genes in approximately half of the isolates. In other isolates, moderate levels of ciprofloxacin resistance (MIC 8-16mg/L) were associated with an alteration of ParC, most commonly entailing replacement of serine-79 by phenylalanine. High-level ciprofloxacin resistance (MIC 32-128 mg/L) entailed the additional mutation of GyrA with substitution of serine-83 by phenylalanine. Grepafloxacin MICs >4 mg/L were associated with this GyrA mutation alone; no relationship was detected between grepafloxacin MICs and mutation of the QRDR of parC.

  14. Low-level (gallium-aluminum-arsenide) laser irradiation of Par-C10 cells and acinar cells of rat parotid gland.

    PubMed

    Onizawa, Katsuhiro; Muramatsu, Takashi; Matsuki, Miwako; Ohta, Kazumasa; Matsuzaka, Kenichi; Oda, Yutaka; Shimono, Masaki

    2009-03-01

    We investigated cell response, including cell proliferation and expression of heat stress protein and bcl-2, to clarify the influence of low-level [gallium-aluminum-arsenide (Ga-Al-As) diode] laser irradiation on Par-C10 cells derived from the acinar cells of rat parotid glands. Furthermore, we also investigated amylase release and cell death from irradiation in acinar cells from rat parotid glands. The number of Par-C10 cells in the laser-irradiated groups was higher than that in the non-irradiated group at days 5 and 7, and the difference was statistically significant (P < 0.01). Greater expression of heat shock protein (HSP)25 and bcl-2 was seen on days 1 and 3 in the irradiated group. Assay of the released amylase showed no significant difference statistically between the irradiated group and the non-irradiated group. Trypan blue exclusion assay revealed that there was no difference in the ratio of dead to live cells between the irradiated and the non-irradiated groups. These results suggest that low-level laser irradiation promotes cell proliferation and expression of anti-apoptosis proteins in Par-C10 cells, but it does not significantly affect amylase secretion and does not induce rapid cell death in isolated acinar cells from rat parotid glands.

  15. Association of mutation patterns in GyrA and ParC genes with quinolone resistance levels in lactic acid bacteria.

    PubMed

    Li, Shaoying; Li, Zhen; Wei, Wan; Ma, Chunyan; Song, Xiaomin; Li, Shufen; He, Wenying; Tian, Jianjun; Huo, Xiaoyan

    2015-02-01

    The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera Enterococcus and Lactobacillus isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to explore the association of the resistance with the mutation patterns in gyrA and parC genes, as is currently recommended by the Food and Agriculture Organization/World Health Organization Joint Expert Committee in Guidelines for Evaluation of Probiotics in Food for probiotic lactic acid bacteria drug resistance in 2001. The Oxford Cup method and double-tube dilution method were used to determine the quinolone resistance levels of the isolated strains. Generally, all of the 19 strains showed resistance towards norfloxacin and ciprofloxacin when the Oxford cup method was used, whereas the incidence was lower (to norfloxacin 89.5% and to ciprofloxacin 68.4%) when minimum inhibitory concentration breakpoints (CLSI M100-S23) were tested. Furthermore, gene sequencing was conducted on gyrA and parC of topoisomerase II of these isolated strains. The genetic basis for quinolone resistance may be closely related to mutations in gyrA genes as there were 10 mutation sites in amino-acid sequences encoded by gyrA genes in 10 quinolone resistance strains and 14 mutation sites in Enterococcus durans HZ28, whereas no typical mutations were detected in parC genes.

  16. Final design of the Energy-Resolved Neutron Imaging System “RADEN” at J-PARC

    NASA Astrophysics Data System (ADS)

    Shinohara, T.; Kai, T.; Oikawa, K.; Segawa, M.; Harada, M.; Nakatani, T.; Ooi, M.; Aizawa, K.; Sato, H.; Kamiyama, T.; Yokota, H.; Sera, T.; Mochiki, K.; Kiyanagi, Y.

    2016-09-01

    A new pulsed-neutron instrument, named the Energy-Resolved Neutron Imaging System “RADEN”, has been constructed at the beam line of BL22 in the Materials and Life Science Experimental Facility (MLF) of J-PARC. The primary purpose of this instrument is to perform energy-resolved neutron imaging experiments through the effective utilization of the pulsed nature of the neutron beam, making this the world's first instrument dedicated to pulsed neutron imaging experiments. RADEN was designed to cover a broad energy range: from cold neutrons with energy down to 1.05 meV (or wavelength up to 8.8 Å) with a good wavelength resolution of 0.20% to high-energy neutrons with energy of several tens keV (or wavelength of 10-3 Å). In addition, this instrument is intended to perform state-of-the-art neutron radiography and tomography experiments in Japan. Hence, a maximum beam size of 300 mm square and a high L/D value of up to 7500 are provided.

  17. Development of a highly segmented scintillator hodoscope to construct intelligent trigger system for J-PARC E07

    NASA Astrophysics Data System (ADS)

    Oue, Kenichiro; Ekawa, Hiroyuki; Hwang, Sanghoon; Hosomi, Kenji; Hayakawa, Shuhei; Sakaguchi, Atsushi

    2014-09-01

    The purposes of J-PARC E07 are a systematic study of double Lambda hypernuclei with 10 times higher yields than the previous experiment (KEK-E373) and the first measurement of Ξ- atomic X-rays. In the experiment, we produce Ξ- via the quasi-free (K-,K+) reaction off a diamond target and expect to observe 104 stopped Ξ- (Ξ- atoms) in the emulsion counters. The (K-,K+) reaction is measured by using the KURAMA spectrometer and the acceptance of the KURAMA spectrometer is enlarged from the KEK-E373 experiment. So, a sophisticated online trigger system is inevitable to operate the new KURAMA spectrometer. We employ an intelligent three-dimensional matrix trigger system with a fine-beam-hodoscope (FBH), a highly segmented charge-hodoscope (CH) and a time-of-flight wall (TOF). The FBH is placed in the beamline, whereas CH is located at the upstream of the KURAMA magnet and TOF is located at the most downstream. The highly segmented CH consists of 64 segments, and each segment is made of a plastic scintillator 2 mm thickness, 11.5 mm width and 450 mm length. Scintillation light signals are read out with a wave-length-shifting fiber. Multi-pixel photon counters and front-end read-out EASIROC boards are used. The performance of CH is evaluated by using positron beams and cosmic rays. I will present the results of the performance studies of CH.

  18. Event Recording Data Acquisition System and Experiment Data Management System for Neutron Experiments at MLF, J-PARC

    NASA Astrophysics Data System (ADS)

    Nakatani, T.; Inamura, Y.; Moriyama, K.; Ito, T.; Muto, S.; Otomo, T.

    Neutron scattering can be a powerful probe in the investigation of many phenomena in the materials and life sciences. The Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC) is a leading center of experimental neutron science and boasts one of the most intense pulsed neutron sources in the world. The MLF currently has 18 experimental instruments in operation that support a wide variety of users from across a range of research fields. The instruments include optical elements, sample environment apparatus and detector systems that are controlled and monitored electronically throughout an experiment. Signals from these components and those from the neutron source are converted into a digital format by the data acquisition (DAQ) electronics and recorded as time-tagged event data in the DAQ computers using "DAQ-Middleware". Operating in event mode, the DAQ system produces extremely large data files (˜GB) under various measurement conditions. Simultaneously, the measurement meta-data indicating each measurement condition is recorded in XML format by the MLF control software framework "IROHA". These measurement event data and meta-data are collected in the MLF common storage and cataloged by the MLF Experimental Database (MLF EXP-DB) based on a commercial XML database. The system provides a web interface for users to manage and remotely analyze experimental data.

  19. Stability test for power converters in high-powered operations for J-PARC MR main magnets

    NASA Astrophysics Data System (ADS)

    Morita, Yuichi; Kurimoto, Yoshinori; Miura, Kazuki; Sagawa, Ryu; Shimogawa, Tetsushi

    2017-10-01

    The Japan Proton Accelerator Research Complex (J-PARC) aims at achieving a megawatt-class proton accelerator facility. One promising method for increasing the beam power is to shorten the repetition cycle of the main ring from the current cycle of 2.48 s to 1.3 s. In this scheme, however, the increase in the output voltage and the power variation of the electric system are serious concerns for the power supplies of the main magnets. We have been developing a new power supply that provides solutions to these issues. Recently, we proposed a new method for high-powered tests of the converter that does not require a large-scale load and power source. We carried out a high-powered test of ∼100 kVA for the prototype DC/DC converters of the new power supply with this method. This paper introduces the design of the power supply and the results of the high-powered test for the prototype DC/DC converters.

  20. Pressure Rise Analysis When Hydrogen Leak from a Cracked Pipe in the Cryogenic Hydrogen System in J-PARC

    NASA Astrophysics Data System (ADS)

    Tatsumoto, H.; Aso, T.; Hasegawa, S.; Ushijima, I.; Kato, T.; Ohtsu, K.; Ikeda, Y.

    2006-04-01

    As one of the main experimental facilities in the Japan Proton Accelerator Research Complex (J-PARC), an intense spallation neutron source (JSNS) driven by a 1 MW proton beam is being constructed. Cryogenic hydrogen at supercritical pressure is selected as a moderator. The total nuclear heating at the moderators is estimated to be a 3.7 kW. A hydrogen system to cool the moderators has been designed. The most severe off-normal event for the cryogenic hydrogen system is considered to be a hydrogen leak when a pipe cracks. In such a case, the hydrogen must be discharged to atmosphere quickly and safely. An analytical code that simulates the pressure change during a hydrogen leak was developed. A pressure rise analysis for various sized cracks was performed, and the required sizes for relief devices were determined. A safety valve size is φ42.7 mm and a rupture disc for vacuum layer should have a diameter of 37.1 mm, respectively.

  1. Design and Performance Test of Superconducting Transport Solenoid for D-Line at J-PARC Muon Science Facility

    NASA Astrophysics Data System (ADS)

    Tanaka, Yasuyuki; Semba, Tomoyuki; Nakajima, Shotaro; Hagiwara, Yoshiaki; Kido, Shuichi; Murata, Yukihiro; Sasaki, Ken-ichi; Shimomura, Koichiro; Kawamura, Naritoshi; Strasser, Patrick; Makida, Yasuhiro; Ohhata, Hirokatsu; Kurosawa, Noriyuki; Miyake, Yasuhiro

    2017-09-01

    A superconducting transport solenoid for Decay Muon Line (D-line) at J-PARC Muon Science Facility was newly designed and manufactured. It was designed to generate a magnetic field in relatively large region (warm bore diameter 0.2 m), while keeping the same outer dimensions, connection interfaces to the existing refrigerator and the power supply of the previous machine [1-3]. Major changes of both solenoids are the reduction of the central magnetic field, the equipment of a warm bore and the adoption of the high Tc current leads. After the installation to the beam line, the initial cooling test, the excitation test and the emergency shutdown test at the rated current were conducted by KEK in order to confirm cryogenic and magnetic performance. These tests were successfully performed with no damege and indicated the solenoid was precisely manufactured and fulfilled the requirements. The solenoid has been under operation since July, 2015. This report describes the design, the manufacturing process, the magnetic field measurement at room temperature and the results of performance tests conducted by KEK.

  2. Analysis of the Peach Bottom Turbine Trip 2 Experiment by Coupled RELAP5-PARCS Three-Dimensional Codes

    SciTech Connect

    Bousbia-Salah, Anis; Vedovi, Juswald; D'Auria, Francesco; Ivanov, Kostadin; Galassi, Giorgio

    2004-10-15

    Thanks to continuous progress in computer technology, it is now possible to perform best-estimate simulations of complex scenarios in nuclear power plants. This method is carried out through the coupling of three-dimensional (3-D) neutron modeling of a reactor core into system codes. It is particularly appropriate for transients that involve strong interactions between core neutronics and reactor loop thermal hydraulics. For this purpose, the Peach Bottom boiling water reactor turbine trip test was selected to challenge the capability of such coupled codes. The test is characterized by a power excursion induced by rapid core pressurization and a self-limiting course behavior. In order to perform the closest simulation, the coupled thermal-hydraulic system code RELAP5 and 3-D neutron kinetic code PARCS were used. The obtained results are compared to those available from experimental data. Overall, the coupled code calculations globally predict the most significant observed aspects of the transient, such as the pressure wave amplitude across the core and the power course, with an acceptable agreement. However, sensitivity studies revealed that more-accurate code models should be considered in order to better match the void dynamic and the cross-section variations during transient conditions.

  3. The Hippoboscidae (Insecta: Diptera) from Madagascar, with new records from the “Parc National de Midongy Befotaka”

    PubMed Central

    Rahola, N.; Goodman, S.M.; Robert, V.

    2011-01-01

    The Hippoboscidae or “louse-flies” is a family of pupiparous Diptera, which in their adult stage are ectoparasites of mammals and birds. This paper presents a comprehensive review of Malagasy Hippoboscidae. In total, amongst the 213 species of this family known worldwide, 14 have been reported in Madagascar, among which six are considered as endemic to the Malagasy region. In addition, data are presented from a collection of 17 Hippoboscidae obtained from seven species of forest-dwelling birds in the “Parc National de Midongy Befotaka”, southeastern Madagascar, in 2003. The flies in this collection belong to three different species: Icosta malagasii (one), Ornithoica podicipis (ten) and Ornithoctona laticornis (six). The two former species were previously only known from single specimens in museum collections; the later species is distributed across much of the Afrotropical region and the records presented herein are the first for Madagascar. All the seven bird species are new hosts for hippoboscids. We present the first description of the male of Icosta malagasii. An illustrated dichotomous determination key of the 14 Malagasy species, based on morphological criteria only, is presented. PMID:21678788

  4. Designing an elliptical supermirror guide for the high-pressure material science beamline of J-PARC

    NASA Astrophysics Data System (ADS)

    Arima, Hiroshi; Komatsu, Kazuki; Ikeda, Kazuaki; Hirota, Katsuya; Kagi, Hiroyuki

    2009-02-01

    The design of an elliptical neutron guide for the time-of-flight (TOF) powder diffractometer of the high-pressure material science beamline at J-PARC was optimized using the McStas Monte Carlo simulation program to increase neutron flux for a small sample size. We investigated the analytical design in accordance with some requirements such as the gain factor at the small sample size and sufficient resolution at shorter wavelength of incident neutrons. The intensity and divergence with respect to energy dependence for elliptical guide designs were compared with those for the linearly tapered and straight guides. Optimizing the design of the elliptical guide results in the largest gain below 0.70 Å wavelength and gives constant instrumental resolution greater than 1 Å. The guide can support a flux gain of about 2.2 (high-intensity mode, Δ d/ d of ca. 0.6%) and 1.2 (high-resolution mode; Δ d/ d of ca. 0.5%) greater than 1 Å compared to the beamline of the natural flight path with resolution similar to that provided by the optimized elliptical guide.

  5. Amino acid substitutions of quinolone resistance determining regions in GyrA and ParC associated with quinolone resistance in Acinetobacter baumannii and Acinetobacter genomic species 13TU.

    PubMed

    Liu, Yen-Hung; Kuo, Shu-Chen; Lee, Yi-Tzu; Chang, Ian C Y; Yang, Su-Pen; Chen, Te-Li; Fung, Chang-Phone

    2012-04-01

    Amino acid substitutions in GyrA and ParC are associated with resistance to quinolones in Acinetobacter baumannii (A baumannii), but this association is rarely elucidated in Acinetobacter genomic species (AGS) 13TU. This study aims to compare the association of amino acid substitutions in GyrA and ParC with quinolone resistance in A baumannii and AGS 13TU in Taiwan. Eleven representative strains of A baumannii and 13 strains of AGS 13TU were selected from 402 bacteremic isolates. The sequences of quinolone resistance determining regions of gyrA and parC were determined. Minimal inhibitory concentrations (MICs) of nalidixic acid, ciprofloxacin, levofloxacin and moxifloxacin were determined by agar dilution method. Ser83Leu substitution in GyrA in A baumannii (one strain) was associated with resistance to all tested quinolones. This substitution plus a Ser80Leu or Ser80Tyr in ParC in A baumannii (four strains) and AGS 13TU (two strains) were associated with higher MICs of all quinolones. All but one quinolone MICs of A baumannii (one strain) and AGS 13TU (two strains) carrying a single substitution Ser56Asn in ParC remained in the susceptibility breakpoint. The Ser83Leu substitution in GyrA, even with additional Ser56Asn substitution in ParC, was associated with resistance to only nalidixic acid, but not other newer quinolones in AGS 13TU (two strains). A baumannii and AGS 13TU possessed similar quinolone resistance associated with amino acid substitutions in GyrA and ParC. Further study with more strains is needed to determine whether a single Ser83Leu substitution in GyrA was associated with a high level of quinolone MIC only in A baumannii, but not in AGS 13TU. Copyright © 2011. Published by Elsevier B.V.

  6. The St-Louis du Parc Heart Health Project: a critical analysis of the reverse effects on smoking

    PubMed Central

    Renaud, L; O'Loughlin, J; Dery, V

    2003-01-01

    Objectives: Although some school based smoking prevention programmes have shown positive impacts, others have had only short term effects, no effects, and in some cases reverse effects. The St-Louis du Parc Heart Health Project was a five year heart health promotion programme targeting children in eight elementary schools aged 9–12 years in disadvantaged multiethnic neighbourhoods in Montreal. In a controlled, longitudinal evaluation, the programme produced reverse effects on smoking—children exposed to the programme were more likely to initiate and to continue smoking than control children. This article explores hypotheses to explain the reverse effects. Design: Following work by an in-house committee, a consensus workshop with international experts was conducted to develop hypotheses to explain the reverse effects. This was complemented by an analysis of the programme's concordance with the standard guidelines on the school based prevention of tobacco use, and discussions with experts at the Centers for Disease Control and Prevention. Results: The programme respected most standard guidelines for smoking prevention programmes with respect to content and mode of delivery. Hypotheses to explain the reverse effects include: an unfavourable environment characterised by strong pro-smoking models and resistance to environmental interventions; heightened sensitivity to smoking among children most exposed to the programme; defence mechanisms among children stimulated by cognitive dissonance or anxiety; unanticipated effects associated with the health educator who delivered the programme; inadequate attention in programme development to the diverse cultural origins of the population targeted; and intervention content inappropriately targeted to children's stages of cognitive development. Conclusion: Elementary school based interventions should aim to develop a clear and coherent social norm about the non-use of tobacco, as a precursor to or in close conjunction with

  7. Maintenance and operation procedure, and feedback controls of the J-PARC RF-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2015-04-08

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup −} ion beam of 60mA within normalized emittances of 1.5πmm•mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500μs×25Hz) and a life-time of longer than 1month, the J-PARC cesiated RF-driven H{sup −} ion source was developed by using an internal-antenna developed at the Spallation Neutron Source (SNS). The maintenance and operation procedure to minimize the plasma chamber (PCH) replacement time on the beam line, which is very important to maximize the J-PARC beam time especially for an antenna failure, is presented in this paper. The PCH preserved by filling argon (Ar) gas inside after pre-conditioning including pre-cesiation to produce the required beam at a test-stand successfully produced the required beam on the beam line with slight addition of cesium (Cs). The methods of the feedback controls of a 2MHz-RF-matching, an H{sup −} ion beam intensity and the addition of Cs are also presented. The RF-matching feedback by using two vacuum variable capacitors (VVCs) and RF-frequency shift produced the almost perfect matching with negligibly small reflected RF-power. The H{sup −} ion beam intensity was controlled within errors of ±0.1mA by the RF-power feedback. The amount of Cs was also controlled by remotely opening a Cs-valve to keep the RF-power lower than a settled value.

  8. GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital.

    PubMed

    Gopal, Muthu; Elumalai, Sathishkumar; Arumugam, Suresh; Durairajpandian, Vishnuprabu; Kannan, Munirajan Arasambattu; Selvam, Esthermary; Seetharaman, Srivani

    2016-07-01

    Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the therapeutic failure of fluoroquinolones in patients with Salmonella infection. Resistance to quinolones/ fluoroquinolones commonly arises due to target site mutation. The present study was planned to analyze mutation in Quinolone Resistance Determining Region (QRDR) of quinolone resistant Salmonella isolates. A total of 133 S. Typhi isolates (blood (n = 131), stool (n=1) and bone marrow aspirate (n=1)) from tertiary care hospitals in Chennai and Puducherry, were included in this study. Minimum Inhibitory Concentrations (MIC) were carried out according to the Clinical Laboratory Standard Institute (CLSI)guidelines 2014. Mutations in gyrA and parC genes were analyzed by PCR-RFLP (Restriction Fragment Length Polymorphism) method followed by DNA sequencing. Of the 133 S. Typhi, 99.2% were resistant to nalidixic acid and 21% were resistant to ciprofloxacin by MIC method. 94% of isolates showed Ser 83 mutation in gyrA and 21.8% of isolates showed Trp106-Gly mutation in parC. Mutations in gyrA and parC genes are highly prevalent among Salmonella species. Irrational use of fluoroquinolones may increase the accumulation of mutations in the DNA gyrase and topoisomerase encoding genes, which lead to the emergence of high level fluoroquinolone-resistant Salmonella strains in future.

  9. Rapid Detection of Genomic Mutations in gyrA and parC Genes of Escherichia coli by Multiplex Allele Specific Polymerase Chain Reaction.

    PubMed

    Onseedaeng, Sukanlayanee; Ratthawongjirakul, Panan

    2016-11-01

    Fluoroquinolone (FR) resistant Escherichia coli infection has become a global problem. The FR resistance usually occurs mainly due to specific point of mutations within the quinolone resistance-determining regions (QRDRs) at the gyrA codon of Ser83 and Asp87 and the parC codon of Ser80 and Glu84. Here, we appraised type and frequency of the QRDR mutations in FR-resistant E. coli isolates, and developed multiplex allele specific PCR (MAS-PCR) for the detection of "hot spot" mutations. A total of 111 ciprofloxacin-resistant E. coli from Ramathibodi Hospital in Bangkok, Thailand, were performed Minimum Inhibitory Concentration (MIC) by Etest® and investigated for gyrA and parC genes' mutations by MAS-PCR. Sensitivity and specificity of MAS-PCR were compared to the sequencing method's. Ninety-nine of 111 (89.19%) E. coli isolates had mutation at least one point in the QRDRs. Six usual amino acid substitutes were reported, including Ser83-Lue, Asp87-Asn, Asp87-Tyr, Ser80-Ile, Glu84-Gly, and Glu84-Val. MAS-PCR detected codons 83 and 87 in gyrA and codons 80 and 84 in parC mutations, yielding 96.97%, 100%, 100%, and 93.33% sensitivity, respectively, and 100%, 100%, 100%, and 98.48% specificity, respectively. MAS-PCR may be used for rapid detection of FR resistance in routine laboratory as well as in epidemiology study. © 2016 Wiley Periodicals, Inc.

  10. Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance.

    PubMed

    Yan, S S; Fox, M L; Holland, S M; Stock, F; Gill, V J; Fedorko, D P

    2000-11-01

    A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine and that methionine-99 was changed to leucine, and in parC, predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae.

  11. Resistance to Multiple Fluoroquinolones in a Clinical Isolate of Streptococcus pyogenes: Identification of gyrA and parC and Specification of Point Mutations Associated with Resistance

    PubMed Central

    Yan, S. Steve; Fox, Melissa L.; Holland, Steven M.; Stock, Frida; Gill, Vee J.; Fedorko, Daniel P.

    2000-01-01

    A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine and that methionine-99 was changed to leucine, and in parC, predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae. PMID:11036052

  12. Substitutions of Ser83Leu in GyrA and Ser80Leu in ParC Associated with Quinolone Resistance in Acinetobacter pittii.

    PubMed

    Gu, Dan-xia; Hu, Yun-jian; Zhou, Hong-wei; Zhang, Rong; Chen, Gong-xiang

    2015-06-01

    To investigate the prevalence and the mechanism of quinolone-resistant Acinetobacter pittii, 634 Acinetobacter calcoaceticus-Acinetobacter baumannii complex isolates were collected throughout Zhejiang Province. Identification of isolates was conducted by matrix-assisted laser desorption ionization/time of flight mass spectrometry (MALDI-TOF MS), blaOXA-51-like gene, and partial RNA polymerase β-subunit (rpoB) amplification. Twenty-seven isolates of A. pittii were identified. Among the 634 isolates, A. baumannii, A. pittii, Acinetobacter nosocomialis, and A. calcoaceticus counted for 87.22%, 4.26%, 8.20%, and 0.32%, respectively. Antimicrobial susceptibility of nalidixic acid, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, levofloxacin, sparfloxacin, moxifloxacin, and gatifloxacin for 27 A. pittii were determined by the agar dilution method. Detection of quinolone-resistant determining regions of gyrA, gyrB, parC, and parE was performed for the A. pittii isolates. In addition, plasmid-mediated quinolone resistance (PMQR) determinants (qnrA, qnrB, qnrS, qnrC, qnrD, aac(6')-Ib-cr, qepA, oqxA, and oqxB) were investigated. All the 27 isolates demonstrated a higher minimum inhibitory concentration (MIC) to old quinolones than the new fluoroquinolones. No mutation in gyrA, gyrB, parC, or parE was detected in 20 ciprofloxacin-susceptible isolates. Seven ciprofloxacin-resistant A. pittii were identified with a Ser83Leu mutation in GyrA. Among them, six isolates with simultaneous Ser83Leu amino acid substitution in GyrA and Ser80Leu in ParC displayed higher MIC values against ciprofloxacin. Additionally, three were identified with a Met370Ile substitution in ParE, and two were detected with a Tyr317His mutation in ParE, which were reported for the first time. No PMQR determinants were identified in the 27 A. pittii isolates. In conclusion, mutations in chromosome play a major role in quinolone resistance in A. pittii, while resistance mechanisms mediated by plasmid have

  13. Thermal analysis of injection beam dump of high-intensity rapid-cycling synchrotron in J-PARC

    NASA Astrophysics Data System (ADS)

    Kamiya, J.; Saha, P. K.; Yamamoto, K.; Kinsho, M.; Nihei, T.

    2017-10-01

    The beam dump at the beam injection area in the J-PARC 3-GeV rapid cycling synchrotron (RCS) accepts beams that pass through the charge exchange foil without ideal electron stripping during the multi-turn beam injection. The injection beam dump consists of the beam pipe, beam stopper, radiation shield, and cooling mechanism. The ideal beam power into the injection beam dump is 400 W in the case of design RCS extraction beam power of 1 MW with a healthy foil, which has 99.7 % charge stripping efficiency. On the other hand, as a radiation generator, the RCS is permitted to be operated with maximum average beam power of 4 kW into the injection beam dump based on the radiation shielding calculation, in consideration of lower charge stripping efficiency due to the foil deterioration. In this research, to evaluate the health of the RCS injection beam dump system from the perspective of the heat generation, a thermal analysis was performed based on the actual configuration with sufficiently large region, including the surrounding concrete and soil. The calculated temperature and heat flux density distribution showed the validity of the mesh spacing and model range. The calculation result showed that the dumped 4 kW beam causes the temperature to increase up to 330, 400, and 140 °C at the beam pipe, beam stopper, and radiation shield, respectively. Although these high temperatures induce stress in the constituent materials, the calculated stress values were lower than the ultimate tensile strength of each material. Transient temperature analysis of the beam stopper, which simulated the sudden break of the charge stripper foil, demonstrated that one bunched beam pulse with the maximum beam power does not lead to a serious rise in the temperature of the beam stopper. Furthermore, from the measured outgassing rate of stainless steel at high temperature, the rise in beam line pressure due to additive outgassing from the heated beam pipe was estimated to have a negligible

  14. EPA/IFP (Environmental Protection Agency/Institute Francais Du Petrole) European workshop on the emission of nitrous oxide from fossil-fuel combustion: Rueil-Malmaison, France, June 1-2, 1988

    SciTech Connect

    Ryan, J.V.; Srivastava, R.K.

    1989-10-01

    This report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil-fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increasing atmospheric N2O concentrations have been linked to depletion of stratospheric ozone (O3) and to global-climate warming. The combustion of fossil fuels has been identified as a potential major anthropogenic source of N2O. The workshop had two goals: (1) to exchange information among various international research and industrial groups that are involved in N2O chemistry, modeling, and measurement; and (2) to develop a network for coordinating future related efforts.

  15. Co-existence of plasmid-mediated quinolone resistance determinants and mutations in gyrA and parC among fluoroquinolone-resistant clinical Enterobacteriaceae isolated in a tertiary hospital in Warsaw, Poland.

    PubMed

    Piekarska, Katarzyna; Wołkowicz, Tomasz; Zacharczuk, Katarzyna; Rzeczkowska, Magdalena; Chróst, Anna; Bareja, Elżbieta; Olak, Monika; Gierczyński, Rafał

    2015-03-01

    Plasmid-mediated quinolone resistance (PMQR) determinants and the distribution of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC were investigated in 215 ciprofloxacin-resistant (MIC>1mg/L) clinical Enterobacteriaceae collected during a 6-month prospective study in a tertiary hospital in Warsaw, Poland. PMQR determinants were present in 49 isolates (22.8%), among which aac(6')-Ib-cr and qnrB1 predominated (85.7% and 26.5%, respectively). Mutations in gyrA and parC QRDRs were detected among 89.8% of isolates (MIC≥4mg/L). Changes in Ser-83, Ala-84 and Asp-87 in GyrA and Ser-80 and Glu-84 in ParC were detected. Five isolates with ciprofloxacin MICs in the range 1.5-16 mg/L were found to have unaltered QRDRs, with PMQR as the only fluoroquinolone (FQ) resistance trait detected. The remaining 44 PMQR-positive isolates were found to carry altered QRDRs. Three substitutions (two in GyrA and one in ParC) were detected in 23 isolates, whilst 8 isolates carried four mutations (two in GyrA and two in ParC). One isolate of Klebsiella pneumoniae with two amino acid substitutions in the ParC QRDR in the presence of aac(6')-Ib-cr and qnrB1 had a ciprofloxacin MIC of 16mg/L. The results presented here show that FQ resistance in these clinical Enterobacteriaceae is a complex interplay between PMQR determinants and mutations in gyrA and parC rather than a single stepwise accumulation of mutations in the gyrase and topoisomerase subunits. In addition, these results show the role of PMQR determinants in promoting QRDR mutations and the acquisition of high-level FQ resistance in clinical settings. Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  16. In vitro activity of five quinolones and analysis of the quinolone resistance-determining regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum clinical isolates from perinatal patients in Japan.

    PubMed

    Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto; Yanagihara, Itaru

    2015-04-01

    Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L-GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan.

  17. Evaluation of Ciprofloxacin (gyrA, parC Genes) and Tetracycline (tetB Gene) Resistance in Nosocomial Acinetobacter baumannii Infections

    PubMed Central

    Nowroozi, Jamileh; Akhavan Sepahi, Abbas; Tahmasebinejad Kamarposhti, Lida; Razavipour, Roya; Mazhar, Flor

    2014-01-01

    Background: Acinetobacter baumannii plays an important role in some types of nosocomial infections as an opportunist microorganism which increases levels of resistance to antibacterial drugs and disinfectants. Objectives: The aim of this study was to determine the resistance and sensitivity of A. baumannii to different antibiotics and evaluate the minimal inhibitory concentration (MIC) for Ciprofloxacin and Tetracycline; in addition to Surfanios, Citron and Aniosyme DD1 disinfectants, and also to detect the presence of gyrA, parC and tetB gene bands in the isolates. Materials and Methods: In this study, 65 A. baumannii isolates were collected from the hospitalized patients in NIOC hospital (National Iranian Oil Company hospital) of Tehran, Iran during 2010-2011. The pattern of sensitivity to antibiotics was determined using CSLI disk diffusion and MIC methods. Furthermore, resistance of isolates to the common disinfectants (Surfanios Citron and Aniosyme DD1) was determined in different hospital wards. Presence of gyrA, parC and tetB gene bands was also detected by PCR method. Results: Frequency of Acinetobacter resistance to Amikacin, Ciprofloxacin, co-Trimoxazole, Ceftazidime and Ceftriaxone was 100% in the isolates reviewed in this study. The frequency of resistance to Gentamicin and Tetracycline were 86.1% in the isolates. The MIC of Ciprofloxacin in all (100%) of isolates was 32-64 μg/mL which showed the resistance to Ciprofloxacin In 86.1% of cases the Gentamicin and Tetracycline MIC were ≥ 16 μg/mL and in 13.9% of isolates the Gentamicin and Tetracycline MIC were 4 μg/mL, these results showed the resistance and sensitivity to the Gentamicin and Tetracycline, respectively. Additionally, all (100%) of the A. baumannii isolates were resistant to disinfectant concentrations, which were used with the methods recommended by manufacturers (0.5%). In 100% of the isolates parC and gyrA genes bands were detected, and tetB gene was also detected in 86.1% of

  18. Rare Kaon Decays, KEK experiment E391 and E14 at the Japan Physics and Accelerator Research Complex (J-PARC)

    SciTech Connect

    Wah, Yau Wai

    2012-12-06

    The goal of the J-PARC neutral kaon experiment (E14/KOTO) is to discover and measure the rate of the kaon rare decay to pi-zero and two neutrinos. This flavor changing neutral current decay proceeds through second-order weak interactions. Other, as yet undiscovered particles, which can mediate the decay could provide an enhancement (or depletion) to the branching ratio which in the Standard Model is accurately predicted within a few percent to be 2.8x10-11. The experiment is designed to observe more than 100 events at the Standard Model branching. It is a follow-up of the KEK E391a experiment and has stage-2 approval by J-PARC PAC in 2007. E14/KOTO has collaborators from Japan (Kyoto, Osaka, Yamagata, Saga), US (Arizona State, Chicago, Michigan Ann Arbor), Taiwan (National Taiwan), Korea, and Russia (Dubna). The experiment exploits the 300kW 30-50 GeV proton delivery of the J-PARC accelerator with a hermetic high acceptance detector with a fine grained Cesium Iodide (CsI) crystal calorimeter, and state of the art electronic front end and data acquisition system. With the recovery of the tsunami disaster on March 11th 2011, E14 is scheduled to start collecting data in December 2012. During the detector construction phase, Chicago focuses on the front end electronics readout of the entire detector system, particularly the CsI calorimeter. The CsI crystals together with its photomultipliers were previously used at the Fermilab KTeV experiment (E832/E799), and were loaned to E14 via this Chicago DOE support. The new readout electronics includes an innovative 10-pole pulse-shaping technique coupled with high speed digitization (14-bit 125MHz and 12-bit 500MHz). This new instrument enables us to measure both energy and timing, particularly with timing resolution better than 100 psec. Besides the cost saving by elimination of the standard time to digital converters, it is now possible to measure the momenta of the final state photons for additional background suppression

  19. Fabrication of silica aerogel with n=1.08 for e+ /μ+ separation in a threshold Cherenkov counter of the J-PARC TREK/E36 experiment

    NASA Astrophysics Data System (ADS)

    Tabata, Makoto; Toyoda, Akihisa; Kawai, Hideyuki; Igarashi, Youichi; Imazato, Jun; Shimizu, Suguru; Yamazaki, Hirohito

    2015-09-01

    This study presents the development of hydrophobic silica aerogel for use as a radiator in threshold-type Cherenkov counters. These counters are to be used for separating positrons and positive muons produced by kaon decay in the J-PARC TREK/E36 experiment. We chose to employ aerogel with a refractive index of 1.08 to identify charged particles with momenta of approximately 240 MeV/c, and the radiator block shape was designed with a trapezoidal cross-section to fit the barrel region surrounding the kaon stopping target in the center of the TREK/E36 detector system. Including spares, we obtained 30 crack-free aerogel blocks segmented into two layers, each layer having a thickness of 2 cm and a length of 18 cm, to fill 12 counter modules. Optical measurements showed that the produced aerogel tiles had the required refractive indices and transparency.

  20. Update on the Intercontinental Cooperative ITP Study Group (ICIS) and on the Pediatric and Adult Registry on Chronic ITP (PARC ITP).

    PubMed

    Kühne, Thomas

    2013-01-01

    The Intercontinental Cooperative ITP Study Group (ICIS) was founded in 1997, when the American practice guidelines demonstrated that there is a substantial lack of clinical data. The aim of the group was to promote basic science and clinical research in the field of ITP. Clinical data and more recently DNA is collected to investigate children and adults with ITP. ICIS organizes regular meetings and opened several registries, the most recent being the Pediatric and Adult Registry on Chronic ITP (PARC-ITP), all of which will be briefly discussed. There are many unanswered questions in basic science and clinical research in ITP which need large collaborative studies. The international network of ICIS may be of value in better understanding ITP.

  1. Development of Hyperon Time-Projection-Chamber (HypTPC) for the H-Dibaryon Search Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Hwang, Sanghoon; Imai, Kenichi; Ahn, Jung Keun

    We the E42 collaboration proposed to search for the H-dibaryon in ΛΛ production from (K-, K-) reaction off nuclei by using a high-intensity K- beam at J-PARC with 100 times better statistics than KEK-E224 and E552 experiments. Our proposed experiment will be designed to confirm if the enhancement is due to the H-dibaryon as a ΛΛ resonance or a virtual bound state or ΛΛ final state interaction. We plan to construct a large-acceptance hyperon spectrometer with a Time-Projection-Chamber (HypTPC) to detector ΛΛ particles, simultaneously K+ particle is measured by the KURAMA spectrometer. We expect to collect 11000 ΛΛ events with a mass resolution of 1.0 MeV/c2 near the ΛΛ threshold. The sensitivity of the detector shows two orders of magitude improvement from the present limit.

  2. Effects Due to the Structure and Materials of a Charge Stripping Foil on Activation of the RCS Injection Segment of J-PARC

    NASA Astrophysics Data System (ADS)

    Kato, Shuichi; Yamazaki, Yoshio; Yoshimoto, Masahiro; Kinsho, Michikazu; Sasao, Mamiko; Kenmotsu, Takahiro; Wada, Motoi

    Because of their robustness, Hybrid type thick Boron-doped Carbon (HBC) stripping foils are used in the 3 GeV Rapid Cycling Synchrotron (RCS) of Japan-Proton Accelerator Research Complex (J-PARC). The foil and the supporting structure are irradiated by H- beams. The activation of the surrounding structures and that of the foil itself is the problem to be solved. The ACAT (Atomic Collision in Amorphous Target) code has been modified to calculate the angle straggling of the transmission beam by multiple collisions in the foil. The results did not show any substantial deterioration of the beam optics due to the foil. The gamma spectra measured during a shutdown period of the RCS has been analyzed to see the correlation with the beam transport in the system.

  3. Analysis of a rod withdrawal in a PWR core with the neutronic- thermalhydraulic coupled code RELAP/PARCS and RELAP/VALKIN

    SciTech Connect

    Miro, R.; Maggini, F.; Barrachina, T.; Verdu, G.; Gomez, A.; Ortego, A.; Murillo, J. C.

    2006-07-01

    The Reactor Ejection Accident (REA) belongs to the Reactor Initiated Accidents (RIA) category of accidents and it is part of the licensing basis accident analyses required for pressure water reactors (PWR). The REA at hot zero power (HZP) is characterized by a single rod ejection from a core position with a very low power level. The evolution consists basically of a continuous reactivity insertion. The main feature limiting the consequences of the accident in a PWR is the Doppler Effect. To check the performance of the coupled code RELAP5/PARCS2.5 and RELAP5/VALKIN a REA in Trillo NPP is simulated. These analyses will allow knowing more accurately the PWR real plant phenomenology in the RIA most limiting conditions. (authors)

  4. Persistence of Mycoplasma hyopneumoniae in experimentally infected pigs after marbofloxacin treatment and detection of mutations in the parC gene.

    PubMed

    Le Carrou, J; Laurentie, M; Kobisch, M; Gautier-Bouchardon, A V

    2006-06-01

    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser80-->Phe and Asp84-->Asn), and one point mutation was observed just behind the QRDR of ParC (Ala116-->Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC.

  5. Persistence of Mycoplasma hyopneumoniae in Experimentally Infected Pigs after Marbofloxacin Treatment and Detection of Mutations in the parC Gene

    PubMed Central

    Le Carrou, J.; Laurentie, M.; Kobisch, M.; Gautier-Bouchardon, A. V.

    2006-01-01

    The ability of Mycoplasma hyopneumoniae to persist despite fluoroquinolone treatments was investigated with pigs. Groups of specific-pathogen-free pigs were experimentally infected with M. hyopneumoniae strain 116 and treated with marbofloxacin at the therapeutic dose (TD) or half of the therapeutic dose (TD/2) for 3 days. Results showed that, despite tissue penetration of marbofloxacin, particularly in the trachea and the tracheal secretions, the treatments did not have any influence on M. hyopneumoniae recovery from tracheal swabs. Mycoplasmas were also isolated from inner organs and tissues such as liver, spleen, kidneys, and bronchial lymph nodes. Recontamination of pigs via environment could not explain mycoplasma persistence after medication, as decontamination of pigs and allocation to a new disinfected environment did not have any significant effect on the phenomenon. A significant decrease in the susceptibility level to marbofloxacin of 12 mycoplasma clones reisolated after the treatments (TD/2 and TD) was observed. Two point mutations were found in the ParC quinolone resistance-determining region (QRDR) of DNA topoisomerase IV (Ser80→Phe and Asp84→Asn), and one point mutation was observed just behind the QRDR of ParC (Ala116→Glu). This is the first time that mutations in a gene coding for topoisomerase IV have been described for M. hyopneumoniae after in vivo marbofloxacin treatments in experimentally infected pigs. However, development of resistance is not sufficient to explain M. hyopneumoniae persistence in vivo since (i) marbofloxacin concentrations were above the marbofloxacin MIC of the wild-type strain and (ii) mycoplasmas reisolated after a single injection of marbofloxacin did not display an increased marbofloxacin MIC. PMID:16723552

  6. Comparative In Vitro Activities of Ciprofloxacin, Clinafloxacin, Gatifloxacin, Levofloxacin, Moxifloxacin, and Trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes Clinical Isolates with Alterations in GyrA and ParC Proteins

    PubMed Central

    Brisse, Sylvain; Milatovic, Dana; Fluit, Ad C.; Verhoef, Jan; Martin, Nele; Scheuring, Sybille; Köhrer, Karl; Schmitz, Franz-Josef

    1999-01-01

    The in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin were tested against 72 ciprofloxacin-resistant and 28 ciprofloxacin-susceptible isolates of Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes. Irrespective of the alterations in GyrA and ParC proteins, clinafloxacin exhibited greater activity than all other fluoroquinolones tested against K. pneumoniae and E. aerogenes. PMID:10428935

  7. Mutations in the gyrA and parC genes and in vitro activities of fluoroquinolones in 114 clinical isolates of Pseudomonas aeruginosa derived from urinary tract infections and their rapid detection by denaturing high-performance liquid chromatography.

    PubMed

    Matsumoto, Minori; Shigemura, Katsumi; Shirakawa, Toshiro; Nakano, Yuzo; Miyake, Hideaki; Tanaka, Kazushi; Kinoshita, Shohiro; Arakawa, Soichi; Kawabata, Masato; Fujisawa, Masato

    2012-11-01

    Fluoroquinolone (FQ) resistance in Pseudomonas aeruginosa has spread. The purpose of this study was to investigate the correlation between representative FQ, i.e. levofloxacin (LVX), resistance and mutations in the gyrA and parC genes of P. aeruginosa clinical isolates from the urine of urinary tract infection patients and their rapid detection by denaturing high-performance liquid chromatography (DHPLC). The susceptibility to LVX of 114 clinical isolates was measured and the quinolone resistance-determining regions (QRDRs) in the gyrA and parC genes of these isolates were sequenced. DHPLC was undertaken to correlate the distinctive chromatograms with their DNA mutation patterns. Among 114 isolates tested, 22 isolates (19.3%) were resistant to LVX. Six amino acid mutations were detected (Thr83Ile, Asp87Tyr and Asp87Asn in gyrA and Ser87Leu, Ser87Trp and Glu91Arg in parC), existing alone or in combination. There were 10 kinds of mutation patterns. The presence of two or more kinds of mutation significantly correlated with LVX resistance compared with the wild-type or a single mutation (P<0.0001). DHPLC data identified the number of amino acid mutations with reproducibility distinguishable by peak number and profile of the DHPLC chromatogram. In conclusion, two or more mutations in gyrA and parC were significantly related to LVX resistance in P. aeruginosa. DHPLC facilitated the detection of resistant alleles, providing a rapid (5 min per sample), economical (96 samples per run) and reliable technique for characterising LVX resistance in P. aeruginosa. This rapid detection system could forecast LVX resistance by the DHPLC profile. Copyright © 2012. Published by Elsevier B.V.

  8. Molecular Analysis of Ciprofloxacin Resistance Mechanisms in Malaysian ESBL-Producing Klebsiella pneumoniae Isolates and Development of Mismatch Amplification Mutation Assays (MAMA) for Rapid Detection of gyrA and parC Mutations

    PubMed Central

    Mohd Yusof, Mohd Yasim; Tay, Sun Tee

    2014-01-01

    Ninety-three Malaysian extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6′)-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4– ≥ 32 μg/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6′)-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2 μg/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6′)-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital. PMID:24860827

  9. Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.

    PubMed

    Al-Marzooq, Farah; Mohd Yusof, Mohd Yasim; Tay, Sun Tee

    2014-01-01

    Ninety-three Malaysian extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were investigated for ciprofloxacin resistance. Two mismatch amplification mutation (MAMA) assays were developed and used to facilitate rapid detection of gyrA and parC mutations. The isolates were also screened for plasmid-mediated quinolone resistance (PMQR) genes including aac(6')-Ib-cr, qepA, and qnr. Ciprofloxacin resistance (MICs 4- ≥ 32  μ g/mL) was noted in 34 (37%) isolates, of which 33 isolates had multiple mutations either in gyrA alone (n = 1) or in both gyrA and parC regions (n = 32). aac(6')-Ib-cr was the most common PMQR gene detected in this study (n = 61), followed by qnrB and qnrS (n = 55 and 1, resp.). Low-level ciprofloxacin resistance (MICs 1-2  μ g/mL) was noted in 40 (43%) isolates carrying qnrB accompanied by either aac(6')-Ib-cr (n = 34) or a single gyrA 83 mutation (n = 6). Ciprofloxacin resistance was significantly associated with the presence of multiple mutations in gyrA and parC regions. While the isolates harbouring gyrA and/or parC alteration were distributed into 11 PFGE clusters, no specific clusters were associated with isolates carrying PMQR genes. The high prevalence of ciprofloxacin resistance amongst the Malaysian ESBL-producing K. pneumoniae isolates suggests the need for more effective infection control measures to limit the spread of these resistant organisms in the hospital.

  10. Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study.

    PubMed

    De Castro-Orós, Isabel; Irún, Pilar; Cebolla, Jorge Javier; Rodriguez-Sureda, Victor; Mallén, Miguel; Pueyo, María Jesús; Mozas, Pilar; Dominguez, Carmen; Pocoví, Miguel

    2017-02-21

    Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with ≥2 clinical signs/symptoms of NP-C were considered 'suspected NP-C' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI ≥70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 [4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores ≥70. Plasma 7

  11. Impedance Measurement of an Antenna with Hydrogen Plasma Driven by 13.56 MHz-rf for J-PARC H{sup -} ion source

    SciTech Connect

    Ueno, A.; Namekawa, Y.; Ohkoshi, K.; Ikegami, K.; Oguri, H.

    2011-09-26

    In order to satisfy the Japan Proton Accelerator Research Complex (J-PARC) second stage requirements of an H{sup -} ion beam current of 50 mA and a life-time of 2000 hours, the development of a 13.56 MHz-rf-driven H{sup -} ion source was started by using an antenna developed at the Spallation Neutron Source (SNS). As the first step, the impedance of an antenna with hydrogen plasma, which is one of the most important parameters, was measured. For an rf-power of 0 kW, 1.25 kW or 7.45 kW, it was measured as j84.19+5.107 {Omega}, j80.22+11.82 {Omega} or j58.24+21.16 {Omega}, respectively. Its real-part had a rather large value and rather large rf-power dependence unexpectedly. By using the measured impedance, the circuit to produce rf-plasma in the plasma chamber on a -50 kV potential with a 13.56 MHz-rf-source on the ground potential was designed by the circuit simulation code LTSpice IV.

  12. Measurement of the neutron capture resonances for platinum using the Ge spectrometer and pulsed neutron beam at the J-PARC/MLF/ANNRI

    NASA Astrophysics Data System (ADS)

    Kino, Koichi; Hasemi, Hiroyuki; Kimura, Atsushi; Kiyanagi, Yoshiaki

    2017-09-01

    The neutron capture cross-section for platinum was measured at J-PARC/MLF/ANNRI. The intense pulsed neutron beam was impinging on a natural platinum foil sample and the emitted prompt γ-rays were detected by a Ge spectrometer. The peak energies of the low energy resonances for natural platinum are consistent with those of the JEFF-3.1.2, RUSFOND2010 and next-JENDL data libraries except for the 20-eV resonance. The resonance cross-sections of the next-JENDL library do not contradict the present measurements within the uncertainty of the absolute value of the present work. We analysed the prompt γ-ray spectrum and found a clear 7921.93 keV peak that originates from the transition from the 196Pt compound state to its ground state. The neutron capture cross-section for 195Pt was obtained by choosing events of this peak. The peak energies of most of the low energy resonances are almost consistent with those of the RUSFOND2010 and next-JENDL libraries. However, there was a disagreement for the 20-eV resonance.

  13. Amino acid substitutions in gyrA and parC associated with quinolone resistance in nalidixic acid-resistant Salmonella isolates

    PubMed Central

    2013-01-01

    This study was undertaken to identify and characterize amino acid substitutions in gyrA and parC related with quinolone resistance of 27 nalidixic acid-resistant (NaR) Salmonella isolates collected in poultry slaughterhouses in Korea. A total of 51 Salmonella isolates were detected from 44.8% (47/105) of the total samples from 15 poultry slaughterhouses examined, among which 27 (52.9%) NaR isolates were detected while ciprofloxacin (Cip) resistance was not present in the isolates. These 27 NaR isolates of DNA sequencing revealed that it contained three types of gyrA mutations in only D87 codon. Mutations in the D87 codon resulted in substitutions to G in most of the isolates, but D87Y and D87N exchanges were also detected. Although Cip resistance was absent, reduced susceptibility characterized by mutations in gyrA was apparent among Salmonella isolates from poultry slaughterhouses in Korea. PMID:24237626

  14. Physics potential of a long-baseline neutrino oscillation experiment using a J-PARC neutrino beam and Hyper-Kamiokande

    NASA Astrophysics Data System (ADS)

    Abe, K.; Aihara, H.; Andreopoulos, C.; Anghel, I.; Ariga, A.; Ariga, T.; Asfandiyarov, R.; Askins, M.; Back, J. J.; Ballett, P.; Barbi, M.; Barker, G. J.; Barr, G.; Bay, F.; Beltrame, P.; Berardi, V.; Bergevin, M.; Berkman, S.; Berry, T.; Bhadra, S.; Blaszczyk, F. d. M.; Blondel, A.; Bolognesi, S.; Boyd, S. B.; Bravar, A.; Bronner, C.; Cafagna, F. S.; Carminati, G.; Cartwright, S. L.; Catanesi, M. G.; Choi, K.; Choi, J. H.; Collazuol, G.; Cowan, G.; Cremonesi, L.; Davies, G.; De Rosa, G.; Densham, C.; Detwiler, J.; Dewhurst, D.; Di Lodovico, F.; Di Luise, S.; Drapier, O.; Emery, S.; Ereditato, A.; Fernández, P.; Feusels, T.; Finch, A.; Fitton, M.; Friend, M.; Fujii, Y.; Fukuda, Y.; Fukuda, D.; Galymov, V.; Ganezer, K.; Gonin, M.; Gumplinger, P.; Hadley, D. R.; Haegel, L.; Haesler, A.; Haga, Y.; Hartfiel, B.; Hartz, M.; Hayato, Y.; Hierholzer, M.; Hill, J.; Himmel, A.; Hirota, S.; Horiuchi, S.; Huang, K.; Ichikawa, A. K.; Iijima, T.; Ikeda, M.; Imber, J.; Inoue, K.; Insler, J.; Intonti, R. A.; Irvine, T.; Ishida, T.; Ishino, H.; Ishitsuka, M.; Itow, Y.; Izmaylov, A.; Jamieson, B.; Jang, H. I.; Jiang, M.; Joo, K. K.; Jung, C. K.; Kaboth, A.; Kajita, T.; Kameda, J.; Karadhzov, Y.; Katori, T.; Kearns, E.; Khabibullin, M.; Khotjantsev, A.; Kim, J. Y.; Kim, S. B.; Kishimoto, Y.; Kobayashi, T.; Koga, M.; Konaka, A.; Kormos, L. L.; Korzenev, A.; Koshio, Y.; Kropp, W. R.; Kudenko, Y.; Kutter, T.; Kuze, M.; Labarga, L.; Lagoda, J.; Laveder, M.; Lawe, M.; Learned, J. G.; Lim, I. T.; Lindner, T.; Longhin, A.; Ludovici, L.; Ma, W.; Magaletti, L.; Mahn, K.; Malek, M.; Mariani, C.; Marti, L.; Martin, J. F.; Martin, C.; Martins, P. P. J.; Mazzucato, E.; McCauley, N.; McFarland, K. S.; McGrew, C.; Mezzetto, M.; Minakata, H.; Minamino, A.; Mine, S.; Mineev, O.; Miura, M.; Monroe, J.; Mori, T.; Moriyama, S.; Mueller, T.; Muheim, F.; Nakahata, M.; Nakamura, K.; Nakaya, T.; Nakayama, S.; Needham, M.; Nicholls, T.; Nirkko, M.; Nishimura, Y.; Noah, E.; Nowak, J.; Nunokawa, H.; O'Keeffe, H. M.; Okajima, Y.; Okumura, K.; Oser, S. M.; O'Sullivan, E.; Ovsiannikova, T.; Owen, R. A.; Oyama, Y.; Pérez, J.; Pac, M. Y.; Palladino, V.; Palomino, J. L.; Paolone, V.; Payne, D.; Perevozchikov, O.; Perkin, J. D.; Pistillo, C.; Playfer, S.; Posiadala-Zezula, M.; Poutissou, J.-M.; Quilain, B.; Quinto, M.; Radicioni, E.; Ratoff, P. N.; Ravonel, M.; Rayner, M. A.; Redij, A.; Retiere, F.; Riccio, C.; Richard, E.; Rondio, E.; Rose, H. J.; Ross-Lonergan, M.; Rott, C.; Rountree, S. D.; Rubbia, A.; Sacco, R.; Sakuda, M.; Sanchez, M. C.; Scantamburlo, E.; Scholberg, K.; Scott, M.; Seiya, Y.; Sekiguchi, T.; Sekiya, H.; Shaikhiev, A.; Shimizu, I.; Shiozawa, M.; Short, S.; Sinnis, G.; Smy, M. B.; Sobczyk, J.; Sobel, H. W.; Stewart, T.; Stone, J. L.; Suda, Y.; Suzuki, Y.; Suzuki, A. T.; Svoboda, R.; Tacik, R.; Takeda, A.; Taketa, A.; Takeuchi, Y.; Tanaka, H. A.; Tanaka, H. K. M.; Tanaka, H.; Terri, R.; Thompson, L. F.; Thorpe, M.; Tobayama, S.; Tolich, N.; Tomura, T.; Touramanis, C.; Tsukamoto, T.; Tzanov, M.; Uchida, Y.; Vagins, M. R.; Vasseur, G.; Vogelaar, R. B.; Walter, C. W.; Wark, D.; Wascko, M. O.; Weber, A.; Wendell, R.; Wilkes, R. J.; Wilking, M. J.; Wilson, J. R.; Xin, T.; Yamamoto, K.; Yanagisawa, C.; Yano, T.; Yen, S.; Yershov, N.; Yokoyama, M.; Zito, M.

    2015-05-01

    Hyper-Kamiokande will be a next-generation underground water Cherenkov detector with a total (fiducial) mass of 0.99 (0.56) million metric tons, approximately 20 (25) times larger than that of Super-Kamiokande. One of the main goals of Hyper-Kamiokande is the study of CP asymmetry in the lepton sector using accelerator neutrino and anti-neutrino beams. In this paper, the physics potential of a long-baseline neutrino experiment using the Hyper-Kamiokande detector and a neutrino beam from the J-PARC proton synchrotron is presented. The analysis uses the framework and systematic uncertainties derived from the ongoing T2K experiment. With a total exposure of 7.5 MW × 10^7s integrated proton beam power (corresponding to 1.56 × 10^{22} protons on target with a 30 GeV proton beam) to a 2.5^circ off-axis neutrino beam, it is expected that the leptonic CP phase δ _{CP} can be determined to better than 19 degrees for all possible values of δ _{CP}, and CP violation can be established with a statistical significance of more than 3 σ (5 σ) for 76{%} (58{%}) of the {δ _{CP}} parameter space. Using both ν _e appearance and ν _μ disappearance data, the expected 1σ uncertainty of sin ^2θ _{23} is 0.015(0.006) for sin ^2θ _{23}=0.5(0.45).

  15. Measurement of the isomer production ratio for the 112Cd(n ,γ )113Cd reaction using neutron beams at J-PARC

    NASA Astrophysics Data System (ADS)

    Hayakawa, T.; Toh, Y.; Huang, M.; Shizuma, T.; Kimura, A.; Nakamura, S.; Harada, H.; Iwamoto, N.; Chiba, S.; Kajino, T.

    2016-11-01

    The astrophysical origin of a rare isotope 115Sn remains an open question. An isomer (T1 /2=14.1 y ) in 113Cd is an s -process branching point from which a nucleosynthesis flow reaches 115Sn. The s -process abundance of 115Sn depends on the isomer production ratio in the 112Cd(n ,γ )113Cd reaction. However, the ratio has not been measured in an energy region higher than the thermal energy. We have measured γ rays following neutron capture reactions on 112Cd using two cluster high-purity germanium (HPGe) detectors in conjunction with a time-of-flight method at J-PARC. We have obtained the result that the relative γ -ray intensity ratio of the isomer is almost constant in an energy region of up to 5 keV. This result suggests that the s -process contribution to the solar abundance of 115Sn is minor. We have found that the ratio of a resonance at 737 eV is about 1.5 times higher than other ratios. This enhancement can be explained by a p -wave neutron capture. This result suggests measurements of decay γ rays to isomers are effective to assign the spin and parity for neutron capture resonances.

  16. In Vitro Activity of Five Quinolones and Analysis of the Quinolone Resistance-Determining Regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum Clinical Isolates from Perinatal Patients in Japan

    PubMed Central

    Kawai, Yasuhiro; Nakura, Yukiko; Wakimoto, Tetsu; Nomiyama, Makoto; Tokuda, Tsugumichi; Takayanagi, Toshimitsu; Shiraishi, Jun; Wasada, Kenshi; Kitajima, Hiroyuki; Fujita, Tomio; Nakayama, Masahiro; Mitsuda, Nobuaki; Nakanishi, Isao; Takeuchi, Makoto

    2015-01-01

    Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited. The purpose of this study was to determine susceptibilities to five quinolones of Ureaplasma urealyticum and Ureaplasma parvum isolated from perinatal samples in Japan and to characterize the quinolone resistance-determining regions in the gyrA, gyrB, parC, and parE genes. Out of 28 clinical Ureaplasma strains, we isolated 9 with high MICs of quinolones and found a single parC gene mutation, resulting in the change S83L. Among 158 samples, the ParC S83L mutation was found in 37 samples (23.4%), including 1 sample harboring a ParC S83L–GyrB P462S double mutant. Novel mutations of ureaplasmal ParC (S83W and S84P) were independently found in one of the samples. Homology modeling of the ParC S83W mutant suggested steric hindrance of the quinolone-binding pocket (QBP), and de novo prediction of peptide structures revealed that the ParC S84P may break/kink the formation of the α4 helix in the QBP. Further investigations are required to unravel the extent and mechanism of antibiotic resistance of Ureaplasma spp. in Japan. PMID:25645833

  17. From rifting to spreading - seismic structure of the rifted western Mariana extinct arc and the ParceVela back-arc basin

    NASA Astrophysics Data System (ADS)

    Grevemeyer, Ingo; Kodaira, Shuichi; Fujie, Gou; Takahashi, Narumi

    2017-04-01

    The proto Izu-Ogasawara (Bonin)-Mariana (IBM) Island arc was created when subduction of the Pacific plate began during the Eocene. Today, the Kyushu-Palau Ridge (KPR) at the centre of the Philippine Sea and the western Mariana Ridge (WMR) are considered to be a remnant of the proto IBM Island arc. The KPR and WMR were separated when back-arc spreading began at 30 to 29 Ma in the Shikoku Basin and ParceVela Basin (PVB). Volcanic activity along the arcs diminished at 27 Ma and there is little evidence of volcanic activity between 23-17 Ma. Arc volcanism was reactivated at 15 Ma, when the opening of the Shikoku Basin and PVB ceased. At about 5 Ma the Mariana Basin opened, rifting the WMR from the Mariana arc. Here, we report results from the seismic refraction and wide-angle profile MR101c shot in summer of 2003 by the Japan Agency for Marine-Earth Science and Technology (JAMSTEC) aboard the RV KAIYO during the cruise KY03-06, extending from the PVB across the WMR and terminating just to the east of the WMR. Along MR101c 46 OBS recorded shots from an airgun array of 12,000 cubic inches (197 litres); 44 OBS provided excellent P-wave data, including arrivals sampling the crust (Pg), the crust/mantle boundary (PmP), the uppermost mantle (Pn) and a deep reflection (PnP) under the WMR. To yield the seismic velocity structure, we used a joint reflection and refraction tomography, revealing the crustal and mantle P-wave velocity structure, the seismic Moho, and a deep-seated reflector. Distinct features are a 14 km thick crust forming the WMR, a high-velocity lower crust in both transition zones to the ParceVela Basin and Mariana Basin, and a reflector at 24 km depth, which shallows to 18 km in the transition zone to the Mariana Basin, perhaps reflecting rifting-related thinning of the entire lithosphere. The deep-reflector, however, did not occur under the PVB. Upper mantle velocity below the WMR is <7.5 km/s. High velocities of the lower crust of the WMR flanking the

  18. The Difficult Case of Crystallization and Structure Solution for the ParC55 Breakage-Reunion Domain of Topoisomerase IV from Streptococcus pneumoniae

    PubMed Central

    Sohi, Maninder K.; Veselkov, Dennis A.; Laponogov, Ivan; Pan, Xiao-Su; Fisher, L. Mark; Sanderson, Mark R.

    2008-01-01

    Background Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis. The emergence and increasing prevalence of resistance to penicillin and other antibiotics has led to interest in other anti-pneumonococcal drugs such as quinolones that target the enzymes DNA gyrase and topoisomerase IV. During crystallization and in the avenues to finding a method to determine phases for the structure of the ParC55 breakage-reunion domain of topoisomerase IV from Streptococcus pneumoniae, obstacles were faced at each stage of the process. These problems included: majority of the crystals being twinned, either non-diffracting or exhibiting a high mosaic spread. The crystals, which were grown under conditions that favoured diffraction, were difficult to flash-freeze without loosing diffraction. The initial structure solution by molecular replacement failed and the approach proved to be unviable due to the complexity of the problem. In the end the successful structure solution required an in-depth data analysis and a very detailed molecular replacement search. Methodology/Principal Findings Crystal anti-twinning agents have been tested and two different methods of flash freezing have been compared. The fragility of the crystals did not allow the usual method of transferring the crystals into the heavy atom solution. Consequently, it was necessary to co-crystallize in the presence of the heavy atom compound. The multiple isomorphous replacement approach was unsuccessful because the 7 cysteine mutants which were engineered could not be successfully derivatized. Ultimately, molecular replacement was used to solve the structure by sorting through a large number of solutions in space group P1 using CNS. Conclusions/Significance The main objective of this paper is to describe the obstacles which were faced and overcome in order to acquire data sets on such difficult crystals and determine phases

  19. Apprenez la Science en Francais?

    ERIC Educational Resources Information Center

    Edmonds, Juliet; Jacobs, Pippa

    2011-01-01

    The authors explain why integrating the teaching of science and French is not as ridiculous as it may at first sound. They describe how this innovative integrated approach works in a primary school in Oxfordshire. The project involves Content and Language Integrated Learning (CLIL). CLIL is a method whereby a curriculum subject is planned and…

  20. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H{sup −} ion source

    SciTech Connect

    Ueno, A. Koizumi, I.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2014-02-15

    The prototype rf-driven H{sup −} ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H{sup −} ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (T{sub PE}) of about 120 °C compared with the typically used T{sub PE} of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H{sup −} ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  1. Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.

    PubMed

    Liu, Bao-Tao; Liao, Xiao-Ping; Yang, Shou-Shen; Wang, Xiu-Mei; Li, Lu-Lu; Sun, Jian; Yang, Yu-Rong; Fang, Liang-Xing; Li, Liang; Zhao, Dong-Hao; Liu, Ya-Hong

    2012-11-01

    In this study, the prevalence of plasmid-mediated quinolone resistance (PMQR) was investigated in 495 Escherichia coli isolates from diseased food-producing animals in Guangdong province, China. The quinolone resistance-determining regions (QRDRs) of the gyrA and parC genes were analysed for mutations in 55 isolates harbouring only oqxAB and all isolates harbouring other PMQR genes. Overall, 282 (57.0 %) E. coli isolates had at least one PMQR gene. oqxAB was detected in 215 isolates and predominated the PMQR genes, followed by qnrS (63 isolates), aac(6')-Ib-cr (56 isolates), qnrB (39 isolates) and qepA (18 isolates). qnrA, qnrC and qnrD were not found in any of the isolates. The rates of resistance to ciprofloxacin, enrofloxacin, levofloxacin and nalidixic acid were 75.2, 81.0, 70.5 and 97.4 %, respectively, among the 495 isolates. Eight types of mutation in gyrA were detected in 154 PMQR-positive isolates, and 147 isolates were found to have mutations in parC. PFGE analysis indicated that the PMQR-positive E. coli isolates were genetically diverse. This study demonstrated that the number of mutations in QRDRs of gyrA and/or parC was significantly associated with the MICs of quinolones (P<0.01). The rates of resistance to ciprofloxacin, enrofloxacin and nalidixic acid in PMQR-positive isolates were significantly higher than those in PMQR-negative isolates (P<0.05). In addition, the prevalence of oqxAB had significant Spearman correlation coefficients in relation to the MICs of all four tested quinolones (P<0.01).

  2. Dependence of beam emittance on plasma electrode temperature and rf-power, and filter-field tuning with center-gapped rod-filter magnets in J-PARC rf-driven H- ion source

    NASA Astrophysics Data System (ADS)

    Ueno, A.; Koizumi, I.; Ohkoshi, K.; Ikegami, K.; Takagi, A.; Yamazaki, S.; Oguri, H.

    2014-02-01

    The prototype rf-driven H- ion-source with a nickel plated oxygen-free-copper (OFC) plasma chamber, which satisfies the Japan Proton Accelerator Research Complex (J-PARC) 2nd stage requirements of a H- ion beam current of 60 mA within normalized emittances of 1.5 π mm mrad both horizontally and vertically, a flat top beam duty factor of 1.25% (500 μs × 25 Hz) and a life-time of more than 50 days, was reported at the 3rd international symposium on negative ions, beams, and sources (NIBS2012). The experimental results of the J-PARC ion source with a plasma chamber made of stainless-steel, instead of nickel plated OFC used in the prototype source, are presented in this paper. By comparing these two sources, the following two important results were acquired. One was that the about 20% lower emittance was produced by the rather low plasma electrode (PE) temperature (TPE) of about 120 °C compared with the typically used TPE of about 200 °C to maximize the beam current for the plasma with the abundant cesium (Cs). The other was that by using the rod-filter magnets with a gap at each center and tuning the gap-lengths, the filter-field was optimized and the rf-power necessary to produce the J-PARC required H- ion beam current was reduced typically 18%. The lower rf-power also decreases the emittances.

  3. DNA gyrase and DNA topoisomerase of Bacillus subtilis: expression and characterization of recombinant enzymes encoded by the gyrA, gyrB and parC, parE genes.

    PubMed

    Barnes, Marjorie H; LaMarr, William A; Foster, Kimberly A

    2003-06-01

    Bacillus subtilis Bs gyrA and gyrB genes specifying the DNA gyrase subunits, and parC and parE genes specifying the DNA topoisomerase IV subunits, have been separately cloned and expressed in Escherichia coli as hexahistidine (his6)-tagged recombinant proteins. Purification of the gyrA and gyrB subunits together resulted in predominantly two bands at molecular weights of 94 and 73kDa; purification of the parC and parE subunits together resulted in predominantly two bands at molecular weights of 93 and 75kDa, as predicted by their respective sequences. The ability of the subunits to complement their partner was tested in an ATP-dependent decatenation/supercoiling assay system. The results demonstrated that the DNA gyrase and the topoisomerase IV subunits produce the expected supercoiled DNA and relaxed DNA products, respectively. Additionally, inhibition of these two enzymes by fluoroquinolones has been shown to be comparable to those of the DNA gyrases and topoisomerases of other bacterial strains. In sum, the biological and enzymatic properties of these products are consistent with their authenticity as DNA gyrase and DNA topoisomerase IV enzymes from B. subtilis.

  4. High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.

    PubMed

    Leavis, Helen L; Willems, Rob J L; Top, Janetta; Bonten, Marc J M

    2006-03-01

    To substantiate a common genetic background of ciprofloxacin-resistant Enterococcus faecium, 32 ciprofloxacin-resistant (Cip(r)) and 31 ciprofloxacin-susceptible (Cip(s)) isolates from outbreaks, clinical infections, surveillances, and animals from 10 different countries were genotyped by multilocus sequence typing. Additionally, susceptibilities to ampicillin and vancomycin and the presence of esp were determined and the quinolone resistance-determining regions of parC, gyrA, parB, and gyrE were sequenced. High-level Cip(r) (MIC > or = 64 microg/ml) due to point mutations in the quinolone resistance-determining region was unique to a distinct hospital-adapted genetic complex in E. faecium, previously designated CC17. Low-level Cip(r) (MIC = 4 microg/ml) in non-CC17 strains is not attributable to point mutations in any subunit of the topoisomerase genes, and the mechanism of resistance remains unclear. Acquisition of mutations in parC and gyrA, leading to high-level Cip(r), is, in addition to ampicillin resistance and the presence of a putative pathogenicity island, another cumulative step in hospital adaptation of CC17.

  5. First 2 years of Atmospheric CO2 measurements in the Estany Llong plain (2100 masl, Parc Nacional d'Aigüestortes i Estany de Sant Maurici, Pyrenees, Catalonia, Spain).

    NASA Astrophysics Data System (ADS)

    Curcoll, Roger; Recolons, Montserrat; Font, Anna; Agraz, Laura; Parga, Elena; Bacardit, Montse; Camarero, Lluís.; Pueyo, Salva; Rodó, Xavier; Morguí, Josep Anton

    2010-05-01

    Since April 2009, air samples are being taken bi-weekly at 10 GMT in the plain of the Estany Llong at 2100 masl. Estany Llong air sampling site (ELL, 42°34'29''N 0°57'17''E) is a remote site situated in the SW principal valley of the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. New Flask-sampling equipment for Remote Mountain Sites was developed by the Institut Català de Ciències del Clima (IC3) to allow flask sampling in extreme weather conditions and carrying the sampling equipment for more than 10 km without damaging flasks. Dry Air analysis for CO2 are done at the Laboratory of IC3 using two coupled modified IRGA Licor-7000, where both pressure and flow are externally controlled. Far away from populated areas, ELL site acts as a remote site, but it is also responding to discrete events as snow melting, summer cattle breeding on pastures and trekking frequentation. Series of CO2 obtained are included as part of Long Term Ecological Research (LTER) at the Parc Nacional d'Aigüestortes i Estany de Sant Maurici. In the long term, these measurements show the mountain ecosystems contribution and geomorphologic influence on the CO2 budget of the air masses crossing a mountain range.

  6. The Development of a Pirani Vacuum Gauge with a Platinum Wire in the J-PARC 3-GeV Rapid Cycling Synchrotron

    NASA Astrophysics Data System (ADS)

    Ogiwara, Norio; Hikichi, Yusuke; Yoshinari, Yoji

    The back pressure of Turbo-Molecular Pumps (TMPs) is constantly monitored using Pirani gauges at J-PARC (Japan Proton Accelerator Complex) RCS (3-GeV Rapid Cycling Synchrotron) where they are used not only in rough pumping but also evacuations during beam operations. The gauge head needs to be very resistant to vibration and abrupt air inlet etc. in minimizing exposure to radiation during maintenance and hence a 50 μm in diameter W wire was adopted as the filament. This type of Pirani gauge has worked well in monitoring the back pressure of the TMP but it has become difficult to measure the low pressure of less than several Pa with the gauge, which may have been due to changes in the emissivity of the W surface. An attempt was therefore made to develop a gauge head made of Pt wire in allowing pressures as low as 0.1 Pa to be measured. Platinum is one of the best possible materials to use because it is very stable against oxidization. However, ordinary Pt gauge heads are rather weak when it comes to vibrations and abrupt air inlet due to its low tensile strength. In order to improve its toughness the filament was composed of twelve 100 μm in diameter Pt wires that were 65 mm long, resulting in it being capable of enduring a force of 25 N. All the wires were welded in series on metal poles in two separate glass plates, with the poles being electrically insulated. This resulted in the filament, 78 cm long and about 10 Ω at room temperature, being containable in a 5 cm in diameter and 10 cm long cylindrical envelope. The output from the gauge head was then examined as a function of pressure under constant current as the plan was for it to be controlled using the constant current method. Confirmation then took place that the pressures of 0.1 Pa up to 103 Pa were measurable with the gauge using current control in such way that the set value increased with pressure increases in three stages.

  7. PARC Code: Theory and Usage

    DTIC Science & Technology

    1989-12-01

    subsonic velocities, then the static pressure is prescribed, and the density and velocity are extrapolated from upstream . The conservation variables... HIPP =14 BC TYPE 71 OR 7"/’PASS FOR BLOCK 3 JSEG :1 IX : -1NXPP :5 JSEG =2 | | : - 3 NIPP :12 JTYPE FREE NON-CONTIGUOUS KTYPE NOH-CONTIGUCUS

  8. Quinolone resistance mutations in Streptococcus pneumoniae GyrA and ParC proteins: mechanistic insights into quinolone action from enzymatic analysis, intracellular levels, and phenotypes of wild-type and mutant proteins.

    PubMed

    Pan, X S; Yague, G; Fisher, L M

    2001-11-01

    Mutations in DNA gyrase and/or topoisomerase IV genes are frequently encountered in quinolone-resistant mutants of Streptococcus pneumoniae. To investigate the mechanism of their effects at the molecular and cellular levels, we have used an Escherichia coli system to overexpress S. pneumoniae gyrase gyrA and topoisomerase IV parC genes encoding respective Ser81Phe and Ser79Phe mutations, two changes widely associated with quinolone resistance. Nickel chelate chromatography yielded highly purified mutant His-tagged proteins that, in the presence of the corresponding GyrB and ParE subunits, reconstituted gyrase and topoisomerase IV complexes with wild-type specific activities. In enzyme inhibition or DNA cleavage assays, these mutant enzyme complexes were at least 8- to 16-fold less responsive to both sparfloxacin and ciprofloxacin. The ciprofloxacin-resistant (Cip(r)) phenotype was silent in a sparfloxacin-resistant (Spx(r)) S. pneumoniae gyrA (Ser81Phe) strain expressing a demonstrably wild-type topoisomerase IV, whereas Spx(r) was silent in a Cip(r) parC (Ser79Phe) strain. These epistatic effects provide strong support for a model in which quinolones kill S. pneumoniae by acting not as enzyme inhibitors but as cellular poisons, with sparfloxacin killing preferentially through gyrase and ciprofloxacin through topoisomerase IV. By immunoblotting using subunit-specific antisera, intracellular GyrA/GyrB levels were a modest threefold higher than those of ParC/ParE, most likely insufficient to allow selective drug action by counterbalancing the 20- to 40-fold preference for cleavable-complex formation through topoisomerase IV observed in vitro. To reconcile these results, we suggest that drug-dependent differences in the efficiency by which ternary complexes are formed, processed, or repaired in S. pneumoniae may be key factors determining the killing pathway.

  9. In vivo activity of gemifloxacin, moxifloxacin and levofloxacin against pneumococci with gyrA and parC point mutations in a sepsis mouse model measured with the all or nothing mortality end-point.

    PubMed

    Alkorta, M; Giménez, M J; Vicente, D; Aguilar, L; Pérez-Trallero, E

    2005-02-01

    A dose-decreasing immunocompetent sepsis mouse model was used to evaluate the in vivo effect of levofloxacin, moxifloxacin and gemifloxacin, using a ciprofloxacin/levofloxacin susceptible serotype 6B strain (ciprofloxacin MIC: 1 mg/l) and two resistant serotype 14 and 19F strains with gyrA and parC point mutations (ciprofloxacin MICs of 32 and 64 mg/l, respectively). Significant higher in vivo activity was found for moxifloxacin and gemifloxacin than for levofloxacin against strains 1 and 2, and for gemifloxacin versus moxifloxacin or levofloxacin against strain 3. Gemifloxacin treatment resulted in 100% survival against strains 1 and 2(AUC0-24 h/MIC of 30 and 62) but against strain 3, survival was 60-80% (AUC0-24 h/MIC of 93). Similar AUC0-24 h/MIC values produced different therapeutic results suggesting that in vitro parameters other than the MIC could influence efficacy predictions based on in vitro susceptibility tests (MICs) or pharmacodynamic parameters (AUC0-24 h/MIC).

  10. Le Francais quand meme (French Nonetheless).

    ERIC Educational Resources Information Center

    Delautier, Jean-Marie

    1983-01-01

    Political, attitudinal, and administrative problems of teaching compulsory foreign languages in Colombia are described and discussed from the point of view of a French teacher in a system characterized by confusion and lack of student interest. (MSE)

  11. Le Francais Courant (Contemporary French), Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course has been developed basically within the limits of Units 4-6 of "A-LM French: Level 1", second edition. The primary objectives are to develop French vocabulary relative to the family, home, transportation, and foods by continuing to work with short dialogues based on everyday, teenage experiences. While reviewing previously studied…

  12. Le Francais Moderne, (Modern French) Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Performance objectives and broad goals for listening, speaking, reading, and writing skills in French instruction are presented in this text. Cultural awareness and student attitude are also considered. Vocabulary and structure of the course are presented through three situations: shopping, meeting a train, and making vacation plans. Short films…

  13. Les affaires "en francais" (Business "In French").

    ERIC Educational Resources Information Center

    Sanko, Helene N.

    1993-01-01

    A French brochure entitled "700 Current Words for Business" was developed to familiarize the business community with modern French business vocabulary and avoid intrusion of terminology from other languages. Some terms are neologisms. Translations from Latin, Japanese, and English illustrate the etymology and morphological patterns of…

  14. Le Francais quand meme (French Nonetheless).

    ERIC Educational Resources Information Center

    Delautier, Jean-Marie

    1983-01-01

    Political, attitudinal, and administrative problems of teaching compulsory foreign languages in Colombia are described and discussed from the point of view of a French teacher in a system characterized by confusion and lack of student interest. (MSE)

  15. Le Francais Courant, Part VI: Contemporary French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course, developed largely within the framework of units 13, 14, and 15 of the second edition of "A-LM French, Level 2," emphasizes development of basic audiolingual skills. Conversational topics permit the student to review his summer vacation. Principal elements of structure are expressions of quantity, pronouns--including those…

  16. Le Francais Courant (Contemporary French), Part II.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course has been developed basically within the limits of Units 4-6 of "A-LM French: Level 1", second edition. The primary objectives are to develop French vocabulary relative to the family, home, transportation, and foods by continuing to work with short dialogues based on everyday, teenage experiences. While reviewing previously studied…

  17. Le Francais Courant, Part VI: Contemporary French.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This course, developed largely within the framework of units 13, 14, and 15 of the second edition of "A-LM French, Level 2," emphasizes development of basic audiolingual skills. Conversational topics permit the student to review his summer vacation. Principal elements of structure are expressions of quantity, pronouns--including those…

  18. Le Francais Courant, I (Contemporary French, I).

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    Performance objectives focusing on the development of introductory skills in comprehension, speaking, reading, and writing are presented in this text of instructional materials. Lessons center about the use of short dialogues based on everyday, teenage experiences. Special emphasis is placed on vocabulary expansion, present tense of selected…

  19. The PARC Code: Theory and Usage

    DTIC Science & Technology

    1987-10-01

    1937E+01 VA’ RLES AT J ■= 25 81 A6DC-TR-87-24 Listing B-3. Continued K -» ESSURE TEMPERATURE MACH NUMBER TOTAL PRESS U-CDSINf V-COSINE * y 1 u...o o 00 VA’ "JLtS »tL.J’ Lisling B-6. Continued © oo K ■■ ESSURE TEMPERATURE MACH NUMBER TOTAL PRESS U-C05INF V-COSINE U-COSINE X 1 2 1 O

  20. Vers un nouveau phonetisme francais (Toward a New French Phonetics)

    ERIC Educational Resources Information Center

    Monnot, Michel; Kite, Francoise

    1976-01-01

    Evolutionary changes in French pronunciation have necessitated changes in phonetic representation. The new articulatory phenomena involve modifications in syllabic structure and in consonant/vowel relationship. (Text is in French.) (DB)

  1. Roumanie: Le Francais d'abord (Romania: French First).

    ERIC Educational Resources Information Center

    Serren-Rosso, M. L.

    1993-01-01

    Eighty percent of the schools in Iasi, Moldova's capital city, teach French as a second language. The city's French Cultural Center is a focus for educational and cultural information and organization. The center helped upgrade the professional level of teaching following the demise of communism in Eastern Europe. (CNP)

  2. French: An Accommodating Language? = Le Francais: Langue D'Accueil?

    ERIC Educational Resources Information Center

    Wright, Sue, Ed.

    This bilingual book considers recent developments in French attitudes towards language purism, borrowing, and the incursion of English. The book begins with an essay by French sociolinguist Henriette Walter, and most of the following essays are direct responses to her ideas. All chapters are provided in French and English. Chapter titles include…

  3. Morphologie et syntaxe du francais (French Morphology and Syntax)

    ERIC Educational Resources Information Center

    Sourdot, Marc

    1977-01-01

    A study of the relationship of morphology and syntax to the communication process from the functionalist viewpoint. Topics considered are: morphological processes, that is the distinction between functional and contingent language facts; the degree of necessity of syntax; the difference between functionalism and traditional grammar. (Text is in…

  4. Le francais par le theatre. (French through Theater).

    ERIC Educational Resources Information Center

    Agular, Claudio; And Others

    1983-01-01

    The techniques used in a course on "French through the theater" emphasize the dramatic rather than realistic, authentic expression rather than authentic language, and the use of instruction to launch students on their own personal course of learning. (MSE)

  5. Un cours avance de francais: Le francais tel qu'on le parle (An Advanced Course in French: Colloquial French)

    ERIC Educational Resources Information Center

    Creusot, Andre

    1971-01-01

    Second of three articles on an advanced French program sponsored by the Language Department of the State University of Mons, Belgium. Emphasis is on the phonology, lexicology, and syntax of spoken French. (DS)

  6. Un cours avance de francais: Le francais tel qu'on le parle (An Advanced Course in French: Colloquial French)

    ERIC Educational Resources Information Center

    Creusot, Andre

    1971-01-01

    Second of three articles on an advanced French program sponsored by the Language Department of the State University of Mons, Belgium. Emphasis is on the phonology, lexicology, and syntax of spoken French. (DS)

  7. Modeles de rendement langagier: Francais, 12e annee. Francais langue premiere (Models of Linguistic Production: French, 12th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for twelfth grade…

  8. Une Planche de Salut pour le Francais: le Francais Quotidien et les Niveaux de Langue (A Last Resort for French: Everyday French and Language Levels)

    ERIC Educational Resources Information Center

    Jonas, Maurice

    1977-01-01

    Before asking how to teach French, one should ask what French to teach. It is suggested that everyday French, "la langue usuelle," should be the norm for American teachers and textbook writers and editers. Greater utilization of film scenarios and songs of good quality are among the means suggested. (Text is in French.) (AMH)

  9. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Septieme annee (French: Yearly Curriculum. French as a Native Language: Seventh Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for seventh-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  10. Modeles de rendement langagier: Francais, 11e annee. Francais langue premiere (Models of Linguistic Production: French, 11th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for eleventh grade…

  11. Francais: Programme d'etudes du secondaire deuxieme cycle (10-12). Francais langue premiere (French: High School Curriculum [10-12]. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for high school French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  12. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Neuvieme annee (French: Yearly curriculum. French as a Native Language: Ninth year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for ninth-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  13. Francais: Programme d'etudes par annee scolaire. Francais langue premiere: Huitieme annee (French: Yearly Curriculum. French as a Native Language: Eighth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for eighth-year French native language instruction, as revised in 1998. An introductory section offers background information on the curriculum's design, links between the core curriculum and French native language instruction, underlying principles of language instruction, the…

  14. Modeles de rendement langagier: Francais, 10e annee. Francais langue premiere (Models of Linguistic Production: French, 10th Grade. French as a Native Language).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for tenth grade students…

  15. Modeles de rendement langagier: Francais-7e annee. Francais langue premiere (Models of Linguistic Production--French as a Native Language: 7th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for seventh grade students…

  16. NORME PEDAGOGIQUE--LES STRUCTURES INTERROGATIVES DU FRANCAIS (PEDAGOGICAL NORM--THE INTERROGATIVE STRUCTURES OF FRENCH).

    ERIC Educational Resources Information Center

    VALDMAN, ALBERT

    THIS PAPER DISCUSSES THE SELECTION OF A PEDAGOGICAL NORM FOR FRENCH INTERROGATIVE STRUCTURES. SINCE THIS AREA OF FRENCH GRAMMAR IS PARTICULARLY POLYMORPHOUS, OBJECTIVE CRITERIA ARE SET UP TO MAKE THE SELECTION--FREQUENCY, COMPLEXITY, AND EXTENSIVITY. BECAUSE "EST-CE QUE" CAN BE APPLIED WITHOUT EXCEPTION TO ALL TYPES OF KERNEL SENTENCES, IT WAS…

  17. Jouer au football... et apprendre le francais (Playing Football...and Learning French).

    ERIC Educational Resources Information Center

    Gutierrez, Alma Rosa Aguilar; Duarte, Delma Victoria Gonzalez

    1992-01-01

    Two teachers in Costa Rica have adopted a thematic approach to French second-language teaching that uses instructional materials about soccer from the French popular press and television, and related class activities, to motivate their students, for whom soccer is culturally important. (MSE)

  18. Une lecon de francais avec des jeux electroniques (A French Lesson with Electronic Games).

    ERIC Educational Resources Information Center

    Malandain, Jean-Louis

    1996-01-01

    Electronic games are proposed as a means for encouraging students of French to learn and use the language while solving problems. A computerized card game and mine-removal game are offered as illustration of the language skills and vocabulary that can be developed and the appeal that such exercises can have for students. (MSE)

  19. Alors...euh...on parle francais? (So...um...Shall We Speak French?)

    ERIC Educational Resources Information Center

    Frommer, Judith G.; Ishikawa, Wayne

    1980-01-01

    Describes a one-semester conversational course taught at Harvard University designed to teach basic oral communication skills in French with the main emphasis on teaching students to pause while speaking. (AM)

  20. Technoscientific French Teaching Guide = Guide pour l'enseignement du Francais technoscientifique.

    ERIC Educational Resources Information Center

    Muller, Brigitte D.

    This course guide aids university professors in doing research to develop a course in scientific and technical French. The course is intended to aid students in developing communicative skills in French in the context of science and technology. The course introduces students to the culture of France as well as to its industrial and technological…

  1. Enseigner quel francais du tourisme (Which French to Teach for Tourism).

    ERIC Educational Resources Information Center

    Larsson, Bjorn

    1992-01-01

    Development of a course in French for tourism and the hotel industry in Sweden is chronicled, focusing on the process of functional analysis used to determine appropriate language content. A general functional outline of touristic French and an outline of language functions specific to a restaurant situation are presented. (MSE)

  2. Alors...euh...on parle francais? (So...um...Shall We Speak French?)

    ERIC Educational Resources Information Center

    Frommer, Judith G.; Ishikawa, Wayne

    1980-01-01

    Describes a one-semester conversational course taught at Harvard University designed to teach basic oral communication skills in French with the main emphasis on teaching students to pause while speaking. (AM)

  3. On Parle Francais Ici: The People of the St. John Valley Have a Tremendous Advantage.

    ERIC Educational Resources Information Center

    Banville, Beurmond J.

    1995-01-01

    A change in philosophy concerning the maintenance of native languages has led to local efforts to revive the French language in the St. John Valley (Maine), including the formation of a community organization and implementation of language programs in which children in all grades receive daily instruction in French. (LP)

  4. Le Francais des Professions Scientifiques et Techniques (French for the Scientific and Technical Professions).

    ERIC Educational Resources Information Center

    Muller, Brigitte

    Two sequential courses in scientific and technical French developed as a supplement to third- and fourth-year college French, in response to expressed student and industry demand, had as their objectives to develop a general familiarity with products of the large French industrial companies and their United States affiliates and to develop means…

  5. Bibliographie pour enseigner le francais des affaires (Bibliography for Business French Instruction).

    ERIC Educational Resources Information Center

    Dewey, S. Pascale

    This bibliography contains a list of various publications (books, journals, dictionaries, newspapers, magazines) as well as videos, CD-ROMs, Web sites, and the addresses of several French chambers of commerce that would be useful for any English speakers needing to live, do business, or otherwise spend time in France. References are in French or…

  6. L'Enseignement du Francais au Moyen de L'Action (Teaching French through Action).

    ERIC Educational Resources Information Center

    Segal, Bertha

    A teaching guide containing 102 elementary to intermediate level French lessons is presented. The lessons are based on the Total Physical Response technique of second language instruction. They follow the stages of first language acquisition: listening, speaking, and reading. Each of the ten units contains a list of vocabulary words, individual…

  7. Informatique et francais langue etrangere (Information Science and French as a Foreign Language).

    ERIC Educational Resources Information Center

    Abry, Dominique; Scholl, Maryse

    1984-01-01

    An interdisciplinary experiment to develop materials for computer-assisted French instruction at the University of Grenoble is described and the process of translating objectives and strategies into exercises relying on student-machine interaction is chronicled. Three approaches were used: student response using stated rules, recognition…

  8. Uruguay: Le francais en quete d'image (Uruguay: French in Search of an Image).

    ERIC Educational Resources Information Center

    Francais dans le Monde, 1993

    1993-01-01

    The role of French language instruction in Uruguay is assessed. Drawing on results of recent surveys, it is observed that French suffers from a lackluster image, and from a lack of confidence among language teachers themselves. (MSE)

  9. Le francais fonde sur la competence, Novice (Competency Based French, Novice).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. The guide includes 21 topical lessons at the introductory level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues. Lesson topics include: greetings; introducing…

  10. Des citoyens francais a quatre pattes (Four-footed French Citizens).

    ERIC Educational Resources Information Center

    Champ-Renaud, Dominique

    1983-01-01

    A class activity is described involving a panel discussion of the role of dogs in French culture and related issues of public administration such as animal protection laws. Panel members' roles (public officials, veterinarians, etc.), audience roles (dog owner, father of a bitten child, etc.), and followup activities are outlined. (MSE)

  11. Informatique et francais langue etrangere (Information Science and French as a Foreign Language).

    ERIC Educational Resources Information Center

    Abry, Dominique; Scholl, Maryse

    1984-01-01

    An interdisciplinary experiment to develop materials for computer-assisted French instruction at the University of Grenoble is described and the process of translating objectives and strategies into exercises relying on student-machine interaction is chronicled. Three approaches were used: student response using stated rules, recognition…

  12. Francais: Langue de specialite: Gearing Commercial French for the World of 1992.

    ERIC Educational Resources Information Center

    Finel-Honigman, Irene

    In the area of business-related language training, the United States lags behind Europe, where graduate business schools require at least one foreign language with business proficiency for graduation. In most United States institutions, the long-standing policy of departmentalization and a perceived dichotomy between the humanities and traditional…

  13. Le Francais parle. Etudes sociolinguistiques (Spoken French. Sociolinguistic Studies). Current Inquiry into Languages and Linguistics 30.

    ERIC Educational Resources Information Center

    Thibault, Pierrette

    This volume contains twelve articles dealing with the French language as spoken in Quebec. The following topics are addressed: (1) language change and variation; (2) coordinating expressions in the French spoken in Montreal; (3) expressive language as source of language change; (4) the role of correction in conversation; (5) social change and…

  14. Japon: Le francais en sursis? (Japan: French in Stay of Execution?)

    ERIC Educational Resources Information Center

    Pecheur, Jacques

    1991-01-01

    In Japan, second-language instruction and specifically French instruction are at a crossroads. Despite appearances of normalcy, survival of university-level French instruction is threatened by greater current interest in Asian languages. In response, the French Embassy and Japanese Association of French Professors have established a policy to…

  15. Aspirations langagieres: Negociation et apprentissage du francais (Language Aspirations: Negotiation and Learning French).

    ERIC Educational Resources Information Center

    Lepetit, Daniel; Cichocki, Wladyslaw

    1990-01-01

    A survey of 130 beginning French students at the University of Windsor (Canada) focused on their second language aspirations, expectations, and anticipated needs. Interpersonal relations appear to be the primary motivator, with travel and instrumental motivation secondary. (20 references) (Author/MSE)

  16. Japon: Le francais en sursis? (Japan: French in Stay of Execution?)

    ERIC Educational Resources Information Center

    Pecheur, Jacques

    1991-01-01

    In Japan, second-language instruction and specifically French instruction are at a crossroads. Despite appearances of normalcy, survival of university-level French instruction is threatened by greater current interest in Asian languages. In response, the French Embassy and Japanese Association of French Professors have established a policy to…

  17. L'Economie Francais. Units in Economics for French Classes. Intermediate Level.

    ERIC Educational Resources Information Center

    Jennings, Carol; And Others

    Four units on the French economy, designed for classroom use at the intermediate level, are related in their educational objectives: to shed light on French culture and strengthen second language skills. Each unit describes its specific objectives, materials, texts, instructional procedures, and student evaluation methods. Sample tests and…

  18. Vocabulaire de l'education: anglais-francais (Vocabulary of Education, English-French). Second Edition.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The glossary lists, in English, terms commonly used in education and their translations in French. The terminology applies to all levels of education (elementary, secondary, postsecondary) and to all areas of educational theory, instruction, and school administration. In some cases, additional explanatory or usage notes are provided in French. The…

  19. Une lecon de francais avec des jeux electroniques (A French Lesson with Electronic Games).

    ERIC Educational Resources Information Center

    Malandain, Jean-Louis

    1996-01-01

    Electronic games are proposed as a means for encouraging students of French to learn and use the language while solving problems. A computerized card game and mine-removal game are offered as illustration of the language skills and vocabulary that can be developed and the appeal that such exercises can have for students. (MSE)

  20. Le Francais en Contexte avec TACT (French in Context with TACT).

    ERIC Educational Resources Information Center

    Elkabas, Charles; Wooldridge, Russon

    1996-01-01

    Examines the role of reading in the acquisition of French in context, and shows how, in the area of reading, the computer can be transformed into a highly pedagogical teaching/learning tool because of the text retrieval program TACT. (32 references) (Author/CK)

  1. L'Economie Francais. Units in Economics for French Classes. Intermediate Level.

    ERIC Educational Resources Information Center

    Jennings, Carol; And Others

    Four units on the French economy, designed for classroom use at the intermediate level, are related in their educational objectives: to shed light on French culture and strengthen second language skills. Each unit describes its specific objectives, materials, texts, instructional procedures, and student evaluation methods. Sample tests and…

  2. Enseigner quel francais du tourisme (Which French to Teach for Tourism).

    ERIC Educational Resources Information Center

    Larsson, Bjorn

    1992-01-01

    Development of a course in French for tourism and the hotel industry in Sweden is chronicled, focusing on the process of functional analysis used to determine appropriate language content. A general functional outline of touristic French and an outline of language functions specific to a restaurant situation are presented. (MSE)

  3. L'Enseignement du Francais au Moyen de L'Action (Teaching French through Action).

    ERIC Educational Resources Information Center

    Segal, Bertha

    A teaching guide containing 102 elementary to intermediate level French lessons is presented. The lessons are based on the Total Physical Response technique of second language instruction. They follow the stages of first language acquisition: listening, speaking, and reading. Each of the ten units contains a list of vocabulary words, individual…

  4. "Une Certaine idee du francais": The Dilemma for French Language Policy in the 21st Century.

    ERIC Educational Resources Information Center

    Shelly, Sharon L.

    1999-01-01

    The global French-speaking community recognizes the need to better coordinate its efforts to assert the vitality of French in a world increasingly dominated by English. In pursuing this goal, the Francophone world has developed an identity crisis. Defenders of French face difficult questions about the relationship between language and culture and…

  5. Le francais fonde sur la competence, Avance (Competency Based French, Advanced).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. It includes 26 topical lessons at the advanced level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues or texts. Lesson topics include: orienting oneself; discussing…

  6. Chine: Les Chances du Francais (The Fortunes of the French Language in China).

    ERIC Educational Resources Information Center

    Shuning, Zhang

    1996-01-01

    Examines the current situation in China surrounding the teaching of French as a Foreign Language. After the decline of French teaching subsequent to the Cultural Revolution, the language returned to favor around 1970. Chinese students are infatuated with French; many study it as a first or second foreign language. Additionally, French literature…

  7. "L'unilinguisme" francais contre le changement sociolinguistique (French "Unilingualism" versus Sociolinguistic Change).

    ERIC Educational Resources Information Center

    Boyer, Henri

    2001-01-01

    This article describes the French unilingual, also seen as a sociolinguistic ideology, in its varieties, especially since the French Revolution: an ideology based on few representations that are both inner and outer linguistic. The article also discusses the attitude of the unilingual in the collective epilinguistic field of experiment. One…

  8. Chine: Les Chances du Francais (The Fortunes of the French Language in China).

    ERIC Educational Resources Information Center

    Shuning, Zhang

    1996-01-01

    Examines the current situation in China surrounding the teaching of French as a Foreign Language. After the decline of French teaching subsequent to the Cultural Revolution, the language returned to favor around 1970. Chinese students are infatuated with French; many study it as a first or second foreign language. Additionally, French literature…

  9. Le Francais des Professions Scientifiques et Techniques (French for the Scientific and Technical Professions).

    ERIC Educational Resources Information Center

    Muller, Brigitte

    Two sequential courses in scientific and technical French developed as a supplement to third- and fourth-year college French, in response to expressed student and industry demand, had as their objectives to develop a general familiarity with products of the large French industrial companies and their United States affiliates and to develop means…

  10. L'Onomatopee dans la classe de francais (Onomatopoeia in the French Class).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1988-01-01

    Onomatopoeia is overlooked in many French grammar courses but plays a key role in everyday speech. Classification according to the feelings communicated stresses their importance. Students enjoy learning the sounds produced by animals in a second language and discovering the abundance of onomatopoeia in songs, commercials, comic books, and slang.…

  11. Australie: Pour quelques mots de francais (Australia: For a Little French).

    ERIC Educational Resources Information Center

    Monteil, Alain

    1991-01-01

    An Australian campaign to promote French second-language instruction uses the motto, "Big Bucks with a Little French." The campaign accompanies publication of the book "French in Australia: New Prospects," which seeks to reinforce and diversify the image of French and its use around the world, for business and pleasure. (MSE)

  12. Jouer au football... et apprendre le francais (Playing Football...and Learning French).

    ERIC Educational Resources Information Center

    Gutierrez, Alma Rosa Aguilar; Duarte, Delma Victoria Gonzalez

    1992-01-01

    Two teachers in Costa Rica have adopted a thematic approach to French second-language teaching that uses instructional materials about soccer from the French popular press and television, and related class activities, to motivate their students, for whom soccer is culturally important. (MSE)

  13. Une Experience d'enseignement du francais par ordinateur (An Experiment in Teaching French by Computer).

    ERIC Educational Resources Information Center

    Bougaieff, Andre; Lefebvre, France

    1986-01-01

    An experimental program for university summer students of French as a second language that provided a computer resource center and a variety of courseware, authoring aids, and other software for student use is described and the problems and advantages are discussed. (MSE)

  14. La pratique du francais assiste par ordinateur (The Application of Computer-Assisted French).

    ERIC Educational Resources Information Center

    Malandain, Jean-Louis

    1985-01-01

    Language teachers are urged to explore, develop, and use the entire range of applications made possible by the computer and to realize that the computer can do almost anything but generate ideas. (MSE)

  15. Didactique du francais langue seconde, dramatisation, et theatre (French Second Language Teaching, Dramatization, and Theater).

    ERIC Educational Resources Information Center

    Fancy, Alex

    1991-01-01

    Use of dramatics in French second language education is advocated with theoretical and practical arguments, and a four-stage approach to language acquisition through theater is proposed. The approach is based on activities of a bilingual theater troupe that offers Mount Allison University (New Brunswick) students an opportunity to participate in…

  16. Le francais fonde sur la competence, Intermediare (Competency Based French, Intermediate).

    ERIC Educational Resources Information Center

    Dimanche, Maurice

    This instructional guide in French is intended for training Peace Corps volunteers serving in the Central African Republic. It includes 35 topical lessons at the intermediate level, each consisting of briefly stated competency objectives and a number of brief, related situational dialogues. Lesson topics include: introducing oneself; introducing…

  17. Parametres de delimitation des collocations du francais courant (Parameters for Delimiting Collocations in Contemporary French).

    ERIC Educational Resources Information Center

    Bosse-Andrieu, J.; Mareschal, G.

    1998-01-01

    Discusses the definition of collocation, demonstrates that associative word combinations do form a continuum, and proposes some parameters to help delimit the scope of collocations in everyday contemporary French. (Author/VWL)

  18. French/Francais: Mountain Plains Educational Media Council Film Rental Catalog.

    ERIC Educational Resources Information Center

    Blaney, Robert, Comp.

    This is a complete listing of all French-related films in the "1973-75 Mountain Plains Educational Media Council Film Rental Catalog." Those interested in renting any of the films can obtain a catalog for $2.00 from the Bureau of Educational Media, University of Colorado, Stadium Building, Boulder, Colorado 80302. Each of the 104 entries here is…

  19. Technoscientific French Teaching Guide = Guide pour l'enseignement du Francais technoscientifique.

    ERIC Educational Resources Information Center

    Muller, Brigitte D.

    This course guide aids university professors in doing research to develop a course in scientific and technical French. The course is intended to aid students in developing communicative skills in French in the context of science and technology. The course introduces students to the culture of France as well as to its industrial and technological…

  20. Naval Research Laboratory Multiscale Targeting Guidance for T-PARC and TCS-08

    DTIC Science & Technology

    2010-01-01

    Observing Laboratory (EOL) TPARC catalogue Web site (http://catalog.eol.ucar.edu/tparc_2008/). 526 W E A T H E R A N D F O R E C A S T I N G VOLUME 25...T H E R A N D F O R E C A S T I N G VOLUME 25 covered by at least one of these regions. The lead times and optimization times for all the fixed...associated 530 W E A T H E R A N D F O R E C A S T I N G VOLUME 25 FIG. 3. Vertically integrated SV sensitivity (shaded, values in J kg21 given in color bar

  1. Search for Tetraneutron by Pion Double Charge Exchange Reaction at J-PARC

    NASA Astrophysics Data System (ADS)

    Fujioka, Hiroyuki; Fukuda, Tomokazu; Harada, Toru; Hiyama, Emiko; Itahashi, Kenta; Kanatsuki, Shunsuke; Nagae, Tomofumi; Nanamura, Takuya; Nishi, Takahiro

    Tetraneutron (4n) has come back in the limelight, because of recent observation of a candidate resonant state at RIBF. We propose to investigate the pion double charge exchange (DCX) reaction, i.e., 4He(π-, π+), as an alternative way to populate tetraneutron. An intense π- beam with the kinetic energy of ˜850 MeV, much higher than that in past experiments at LAMPF and TRIUMF, will open up a possibility to improve the experimental sensitivity of the formation cross section, which will be much smaller than hitherto known DCX cross sections such as 9Be(π-, π+)9He (g.s.).

  2. Bunch Shape Measurement of 181 MeV Beam in J-PARC Linac

    NASA Astrophysics Data System (ADS)

    Miura, Akihiko; Feschenko, Alexander V.; Mirzojan, Alexander N.; Miyao, Tomoaki; Ouchi, Nobuo; Maruta, Tomofumi; Liu, Yong; Oguri, Hidetomo; Ikegami, Masanori; Hasegawa, Kazuo

    In the Japan Proton Accelerator Research Complex linac, an energy upgrade project was started in 2009 using annular-ring coupled structure (ACS) linac cavities. We decided to use bunch shape monitors (BSM) for monitoring longitudinal beam width measurement to achieve longitudinal matching using two bunchers located upstream of the ACS cavities, where the radio frequency jumps from 324 to 972 MHz. Three BSMs were fabricated and installed in the original beam line. The BSMs were commissioned with the beam and their operability was demonstrated. In this study, we introduce the mechanism of the BSMs, its operability, measurement results with the 181 MeV beam, and consistency check with the respective cavity amplitude. Furthermore, we describe the operational vacuum conditions and outline the improvements to the BSMs' vacuum system.

  3. Status of the RF-driven H⁻ ion source for J-PARC linac.

    PubMed

    Oguri, H; Ohkoshi, K; Ikegami, K; Takagi, A; Asano, H; Ueno, A; Shibata, T

    2016-02-01

    For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than once a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then.

  4. Pulsed ultra-cold neutron production using a Doppler shifter at J-PARC

    NASA Astrophysics Data System (ADS)

    Imajo, S.; Mishima, K.; Kitaguchi, M.; Iwashia, Y.; Yamada, N. L.; Hino, M.; Oda, T.; Ino, T.; Shimizu, H. M.; Yamashita, S.; Katayama, R.

    2016-01-01

    We have constructed a Doppler-shifter-type pulsed ultra-cold neutron (UCN) source at the Materials and Life Science Experiment Facility of the Japan Proton Accelerator Research Complex. Very cold neutrons (VCNs) with 136 m s^{-1} velocity in a neutron beam supplied by a pulsed neutron source are decelerated by reflection on an m=10 wide-band multilayer mirror, yielding pulsed UCNs. The mirror is fixed to the tip of a 2000 rpm rotating arm moving with 68 m s^{-1} velocity in the same direction as the VCNs. The repetition frequency of the pulsed UCNs is 8.33 Hz and the time width of the pulse at production is 4.4 ms. In order to increase the UCN flux, a supermirror guide, wide-band monochromatic mirrors, focus guides, and a UCN extraction guide have been newly installed or improved. The 1 MW-equivalent count rate of the output neutrons with longitudinal wavelengths longer than 58 nm is 1.6 × 102 cps, while that of the true UCNs is 80 cps. The spatial density at production is 1.4 UCN cm^{-3}. This new UCN source enables us to research and develop apparatuses necessary for the investigation of the neutron electric dipole moment.

  5. Improvements of vacuum system in J-PARC 3 GeV synchrotron

    NASA Astrophysics Data System (ADS)

    Kamiya, J.; Hikichi, Y.; Namekawa, Y.; Takeishi, K.; Yanagibashi, T.; Kinsho, M.; Yamamoto, K.; Sato, A.

    2017-07-01

    The RCS vacuum system has been upgraded since the completion of its construction towards the objectives of both better vacuum quality and higher reliability of the components. For the better vacuum quality, (1) pressure of the injection beam line was improved to prevent the H-beam from converting to H0; (2) leakage in the beam injection area due to the thermal expansion was eliminated by applying the adequate torque amount for the clamps; (3) new in-situ degassing method of the kicker magnet was developed. For the reliability increase of the components, (1) A considerable number of fluoroelastmer seal was exchanged to metal seal with the low spring constant bellows and the light clamps; (2) TMP controller for the long cable was developed to prevent the controller failure by the severe electrical noise; (3) A number of TMP were installed instead of ion pumps in the RF cavity section as an insurance for the case of pump trouble.

  6. Planification de la maintenance d'un parc de turbines-alternateurs par programmation mathematique

    NASA Astrophysics Data System (ADS)

    Aoudjit, Hakim

    A growing number of Hydro-Quebec's hydro generators are at the end of their useful life and maintenance managers fear to face a number of overhauls exceeding what can be handled. Maintenance crews and budgets are limited and these withdrawals may take up to a full year and mobilize significant resources in addition to the loss of electricity production. In addition, increased export sales forecasts and severe production patterns are expected to speed up wear that can lead to halting many units at the same time. Currently, expert judgment is at the heart of withdrawals which rely primarily on periodic inspections and in-situ measurements and the results are sent to the maintenance planning team who coordinate all the withdrawals decisions. The degradations phenomena taking place is random in nature and the prediction capability of wear using only inspections is limited to short-term at best. A long term planning of major overhauls is sought by managers for the sake of justifying and rationalizing budgets and resources. The maintenance managers are able to provide a huge amount of data. Among them, is the hourly production of each unit for several years, the repairs history on each part of a unit as well as major withdrawals since the 1950's. In this research, we tackle the problem of long term maintenance planning for a fleet of 90 hydro generators at Hydro-Quebec over a 50 years planning horizon period. We lay a scientific and rational framework to support withdrawals decisions by using part of the available data and maintenance history while fulfilling a set of technical and economic constraints. We propose a planning approach based on a constrained optimization framework. We begin by decomposing and sorting hydro generator components to highlight the most influential parts. A failure rate model is developed to take into account the technical characteristics and unit utilization. Then, replacement and repair policies are evaluated for each of the components then strategies are derived for the whole unit. Traditional univariate policies such as the age replacement policy and the minimal repair policy are calculated. These policies are extended to build alternative bivariate maintenance policy as well as a repair strategy where the state of a component after a repair is rejuvenated by a constant coefficient. These templates form the basis for the calculation of objective function for the scheduling problem. On one hand, this issue is treated as a nonlinear problem where the objective is to minimize the average total maintenance cost per unit of time on an infinite horizon for the fleet with technical and economic constraints. A formulation is also proposed in the case of a finite time horizon. In the event of electricity production variation, and given that the usage profile is known, the influence of production scenarios is reflected on the unit's components through their failure rate. In this context, prognoses on possible resources problems are made by studying the characteristics of the generated plans. On the second hand, the withdrawals are now subjected to two decision criteria. In addition to minimizing the average total maintenance cost per unit of time on an infinite time horizon, the best achievable reliability of remaining turbo generators is sought. This problem is treated as a biobjective nonlinear optimization problem. Finally a series of problems describing multiple contexts are solved for planning renovations of 90 turbo generators units considering 3 major components in each unit and 2 types of maintenance policies for each component.

  7. Event Analysis in Nuclear Emulsion for the E07 Experiment at J-PARC

    NASA Astrophysics Data System (ADS)

    Soe, Myint K.; Endo, Yoko; Hoshino, Kaoru; Ito, Hiroki; Itonaga, Kazunori; Kobayashi, Hidetaka; Tint, Khin T.; Kinbara, Shinji; Mishina, Akihiro; Yoshida, Junya; Nakazawa, Kazuma

    Hammer track events in nuclear emulsion were analyzed to measure the excitation energy of 8Be* (2+) nucleus. The kinetic energies of two alpha particles of hammer track events were obtained from their ranges with use of range-energy relation. The range-energy relation was calibrated by measuring the alpha particle tracks emitted from 212Po of Thorium decay series in the emulsion. From this calibration, we obtained density and shrinkage factor of the emulsion. The excitation energy and width of 8Be* (2+) nucleus were measured to be 3.39 ± 0.24 MeV and Γ = 1.22 ± 0.60 MeV respectively.

  8. PARCS: A Safety Net Community-Based Fitness Center for Low-Income Adults

    PubMed Central

    Keith, NiCole; de Groot, Mary; Mi, Deming; Alexander, Kisha; Kaiser, Stephanie

    2015-01-01

    Background Physical activity (PA) and fitness are critical to maintaining health and avoiding chronic disease. Limited access to fitness facilities in low-income urban areas has been identified as a contributor to low PA participation and poor fitness. Objectives This research describes community-based fitness centers established for adults living in low-income, urban communities and characterizes a sample of its members. Methods The community identified a need for physical fitness opportunities to improve residents’ health. Three community high schools were host sites. Resources were combined to renovate and staff facilities, acquire equipment, and refer patients to exercise. The study sample included 170 members ≥ age 18yr who completed demographic, exercise self-efficacy, and quality of life surveys and a fitness evaluation. Neighborhood-level U.S. Census data were obtained for comparison. Results The community-based fitness centers resulted from university, public school, and hospital partnerships offering safe, accessible, and affordable exercise opportunities. The study sample mean BMI was 35 ± 7.6 (Class II obesity), mean age was 50yr ± 12.5, 66% were black, 72% were female, 66% completed some college or greater, and 71% had an annual household income < $25K and supported 2.2 dependents. Participants had moderate confidence for exercise participation and low fitness levels. When compared to census data, participants were representative of their communities. Conclusion This observational study reveals a need for affordable fitness centers for low-income adults. We demonstrate a model where communities and organizations strategically leverage resources to address disparities in physical fitness and health. PMID:27346764

  9. PARC Analysis of the NASA/GE 2D NRA Mixer/Ejector Nozzle

    NASA Technical Reports Server (NTRS)

    DeBonis, J. R.

    1999-01-01

    Interest in developing a new generation supersonic transport has increased in the past several years. Current projections indicate this aircraft would cruise at approximately Mach 2.4, have a range of 5000 nautical miles and carry at least 250 passengers. A large market for such an aircraft will exist in the next century due to a predicted doubling of the demand for long range air transportation by the end of the century and the growing influence of the Pacific Rim nations. Such a proposed aircraft could more than halve the flying time from Los Angeles to Tokyo. However, before a new economically feasible supersonic transport can be built, many key technologies must be developed. Among these technologies is noise suppression. Propulsion systems for a supersonic transport using current technology would exceed acceptable noise levels. All new aircraft must satisfy FAR 36 Stage III noise regulations. The largest area of concern is the noise generated during takeoff. A concerted effort under NASA's High Speed Research (HSR) program has begun to address the problem of noise suppression. One of the most promising concepts being studied in the area of noise suppression is the mixer/ejector nozzle. This study analyzes a typical noise suppressing mixer ejector nozzle at take off conditions, using a Full Navier-Stokes (FNS) computational fluid dynamics (CFD) code.

  10. PARCS: A Safety Net Community-Based Fitness Center for Low-Income Adults.

    PubMed

    Keith, NiCole; Mi, Deming; Alexander, Kisha; Kaiser, Stephanie; de Groot, Mary

    2016-01-01

    Physical activity (PA) and fitness are critical to maintaining health and avoiding chronic disease. Limited access to fitness facilities in low-income urban areas has been identified as a contributor to low PA participation and poor fitness. This research describes community-based fitness centers established for adults living in low-income, urban communities and characterizes a sample of its members. The community identified a need for physical fitness opportunities to improve residents' health. Three community high schools were host sites. Resources were combined to renovate and staff facilities, acquire equipment, and refer patients to exercise. The study sample included 170 members older than age 18 who completed demographic, exercise self-efficacy, and quality of life surveys and a fitness evaluation. Neighborhood-level U.S. Census data were obtained for comparison. The community-based fitness centers resulted from university, public school, and hospital partnerships offering safe, accessible, and affordable exercise opportunities. The study sample mean body mass index was 35 + 7.6 kg/m(2) (class II obesity), mean age was 50 ± 12.5 years, 66% were Black, 72% were female, 66% completed some college or greater, and 71% had an annual household income of less than $25,000 and supported 2.2 dependents. Participants had moderate confidence for exercise participation and low fitness levels. When compared with census data, participants were representative of their communities. This observational study reveals a need for affordable fitness centers for low-income adults. We demonstrate a model where communities and organizations strategically leverage resources to address disparities in physical fitness and health.

  11. Rebalancing risk management--part 1: The Process for Active Risk Control (PARC).

    PubMed

    Card, Alan J; Ward, James R; Clarkson, P John

    2014-01-01

    Risk assessment, by itself, does nothing to reduce risk or improve safety. It can only change outcomes by informing the design and management of effective risk control interventions. But current practice in healthcare risk management suffers from an almost complete lack of support for risk control. This first installment of a 2-part series on rebalancing risk management describes a new framework to guide risk control practice: The Process for Active Risk Control.

  12. Quels sont les problemes ethiques souleves par l’augmentation des capacites cognitives dans le cadre de la defense : cadre legal francais, position ethique du service de sante des armees francais

    DTIC Science & Technology

    2009-10-01

    ethical principles for conducting researches on humans as animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some...animals has been defined in 1988 and confirmed in the bioethical law in 1994 [3]. Some modifications were added in 2004 in accordance with European texts...Royaume-Uni, le Nuffield Council on Bioethics , organisme privé qui a pour mission d’examiner les questions bioéthiques pour le gouvernement, a publié

  13. Le vocabulaire disponible du francais, Tome 1. Le vocabulaire concret usuel des enfants francais et acadiens: Etude temoin (The Working French Vocabulary, Volume 1. Common Generic Terms Used by French and Acadian Children: A Field Study).

    ERIC Educational Resources Information Center

    Mackey, William F.; And Others

    The first of a two-volume study of the relative accessibility of French vocabulary in French-speaking Canada presents statistical data concerning the frequency, distribution, valence, and accessibility of vocabulary related to 16 fundamental centers of interest found in normal conversation. The scope, procedures, and results of the study are…

  14. L'enseignement du francais par ordinateur: Les programmes conversationnels au Cafe (Cours autodidactique de francais ecrit) [Teaching French by Computer: Conversational Programs in "Cafe" (Self-instructional Course in Written French)].

    ERIC Educational Resources Information Center

    Landriault, Bernard; Connolly, Guy

    1980-01-01

    Computer technology has been used to develop "Cafe," a self-instructional course in written French communication, which is offered to the general public by the University of Montreal. The course consists of three workbooks containing 1200 items dealing with vocabulary, spelling, punctuation, agreements, morphology, syntax, and fine points of…

  15. Cadre conceptuel des programmes de francais a l'elementaire: lignes directrices (Conceptual Framework for Elementary School French Programs: Axes).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The conceptual framework within which Alberta's elementary school French immersion programs are designed is presented. The first of three main sections outlines the evolution of the concept of language and some second language instructional approaches, including the structural, formalist, functional, and communicative approaches. It also discusses…

  16. Francais et langue maternelle en Yougoslavie: convergences et contacts. (French and Native Language in Yugoslavia: Convergences and Contacts.)

    ERIC Educational Resources Information Center

    Vrhovac, Yvonne

    1983-01-01

    Elements of recent national educational reform in Yugoslavia that contribute to the integration of native and foreign language instruction are outlined, touching on instructional techniques for phonology, communicative competence, written and oral expression and comprehension, vocabulary acquisition, and grammar. (MSE)

  17. Vers un renouveau du "mirage americain" dans les lettres francais (Toward a Renewal of the "American Mirage" in French Literature)

    ERIC Educational Resources Information Center

    Huvos, Kornel

    1973-01-01

    Social and political commentary on the alternating images of America projected in French writing through the years; revised version of a paper presented at the 25th Annual Kentucky Foreign Language Conference, Lexington, Kentucky, April 28, 1972. (RL)

  18. De la television pour comprendre les Francais: cours experimental (Understanding the French Through a Study of Television: An Experimental Course).

    ERIC Educational Resources Information Center

    Mariet, Francois

    1986-01-01

    A college French civilization course based on the important role of television in French contemporary culture, as formative of cultural habits, and on its similar importance to contemporary American students is described. (MSE)

  19. Dictionnaire contextuel anglais-francais de l'energie solaire (Contextual English-French Dictionary on Solar Energy).

    ERIC Educational Resources Information Center

    Serre, Robert

    This English-French dictionary on solar energy is intended for translators and purports to contain all the elements necessary for doing quality translations. Each entry contains the following elements: (1) the basic English word with its synonyms and equivalents; (2) the definition in English and reference to its source; and (3) sentences or…

  20. Techniques de Theatre Integrees a l'Enseignement du Francais 1989 = Theatre Techniques Integrated into the Teaching of French, 1989.

    ERIC Educational Resources Information Center

    Parent, Roger

    This curriculum guide presents a methodology for teaching language and literature through role-playing in the classroom and demonstrates to teachers the link that exists between effective communication and the techniques used to achieve it. The new French program views language as an instrument of communication, a concept that implies that…

  1. Du francais a l'espagnol: Une approche pedagogique interactive (From French to Spanish: An Interactive Pedagogical Approach).

    ERIC Educational Resources Information Center

    Palou de Carranza, Elsa

    An individualized, interdisciplinary approach to French second language instruction is discussed in the context of Argentina's secondary education system. An introductory section briefly reviews general problems associated with the compartmentalization of subjects in education and proposes a re-integration of the objectives of French second…

  2. Geographie du francais et de la francite en Louisiane (The Geography of the French Language and Character in Louisiana).

    ERIC Educational Resources Information Center

    Breton, Roland J.-L.

    This study, based on the 1970 U. S. census, concerns Francophones and French influences that are evident, particularly in Louisiana. Four aspects of the question are treated: (1) linguistic minorities in the U. S., especially those of Hispanic and German origin; (2) the history of Franco-Americans; (3) the present state of French in Louisana; and…

  3. Cadre conceptuel des programmes de francais a l'elementaire: lignes directrices (Conceptual Framework for Elementary School French Programs: Axes).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The conceptual framework within which Alberta's elementary school French immersion programs are designed is presented. The first of three main sections outlines the evolution of the concept of language and some second language instructional approaches, including the structural, formalist, functional, and communicative approaches. It also discusses…

  4. Le Plaisir de Lire en Francais par Internet (The Pleasure of Reading in French on the Internet).

    ERIC Educational Resources Information Center

    Bougaieff, Andre

    1999-01-01

    Describes a project designed to make second language reading more pleasurable, noting how computers can help students achieve this goal. The researcher used HyperCard to create reading software with translations appearing in pop-up windows, allowing students to read text with minimal interruption. Students reacted positively to the software, and…

  5. L'Enseignement du francais par le chant au jardin d'enfants (Teaching French in Kindergarten Using the Song)

    ERIC Educational Resources Information Center

    Braem, Bernard

    1977-01-01

    A description of French instruction in kindergarten and primary grades in Louisiana by the method "Chantons avec Jeannot Lapin." It is an audio-visual approach whose goal is to sensitize students to the spoken language. A description of the methodology and a sample lesson plan are given. (Text is in French.) (AMH)

  6. Schwa au niveau avance du francais langue seconde (Schwa at the Advanced Level of French as a Second Language).

    ERIC Educational Resources Information Center

    Thomas, Alain

    2001-01-01

    Discusses part of a large-scale survey on the oral performance of advanced French-as-a-second-language students, as represented by recorded speech. Although schwa rarely leads to semantic confusions, its analysis in word-median or monosyllabic contexts shows interesting phonostylistic variations. (Author/VWL)

  7. Tutoiement et Vouvoiement chez les Lyceens Francais (French Pupils' Use of the Personal Pronouns "Tu" and "Vous")

    ERIC Educational Resources Information Center

    Bustin-Lekeu, Francine

    1973-01-01

    Surveys conducted among secondary school students in Toulon, France in choice of personal pronouns indicate more prevalent use of tu''. Students consider widespread use of tu'' to be more democratic and thought employment of vous'' on certain occasions is a hypocritical and bourgeois habit. (DS)

  8. Vers un renouveau du "mirage americain" dans les lettres francais (Toward a Renewal of the "American Mirage" in French Literature)

    ERIC Educational Resources Information Center

    Huvos, Kornel

    1973-01-01

    Social and political commentary on the alternating images of America projected in French writing through the years; revised version of a paper presented at the 25th Annual Kentucky Foreign Language Conference, Lexington, Kentucky, April 28, 1972. (RL)

  9. Le francais assiste par ordinateur des colleges et des universities du Canada (French CALL in Canadian Colleges and Universities).

    ERIC Educational Resources Information Center

    Bougaieff, Andre

    This directory presents the results of a national survey of Canadian colleges and universities concerning faculty's use of computer-assisted French language instruction. The listings, arranged alphabetically by province or territory, and within these by institution, contain the responding faculty member's name, address, e-mail address, fax and…

  10. Dictionnaire contextuel anglais-francais de l'energie solaire (Contextual English-French Dictionary on Solar Energy).

    ERIC Educational Resources Information Center

    Serre, Robert

    This English-French dictionary on solar energy is intended for translators and purports to contain all the elements necessary for doing quality translations. Each entry contains the following elements: (1) the basic English word with its synonyms and equivalents; (2) the definition in English and reference to its source; and (3) sentences or…

  11. Theatre et enseignement du francais, langue etrangere (Theater and the Teaching of French as a Foreign Language).

    ERIC Educational Resources Information Center

    Maldaner, Aurea

    1980-01-01

    Discusses drama in foreign language instruction, especially as a means of improving oral expression. Two basic approaches are outlined and three techniques that have been used successfully with various age groups are described. (AMH)

  12. Pour Adolescent et Adulte, Francais Langue Etrangere, Niveau 1 (French as a Foreign Language, Level 1, for Adolescents and Adults)

    ERIC Educational Resources Information Center

    Gibert, Pierre

    1975-01-01

    This annotated bibliography lists dictionaries and reading materials including stories and legends, biographies, works relating to cinema, theatre and French civilization, magazines, and educational activities and games for introductory instruction of French as a foreign language to adults and adolescents. (Text is in French.) (CLK)

  13. Techniques de Theatre Integrees a l'Enseignement du Francais 1989 = Theatre Techniques Integrated into the Teaching of French, 1989.

    ERIC Educational Resources Information Center

    Parent, Roger

    This curriculum guide presents a methodology for teaching language and literature through role-playing in the classroom and demonstrates to teachers the link that exists between effective communication and the techniques used to achieve it. The new French program views language as an instrument of communication, a concept that implies that…

  14. Vers Une Analyse systematique de l'interrogation en francais (Toward a Systematic Analysis of the French Interrogative).

    ERIC Educational Resources Information Center

    Azoulay-Vicente, Avigail

    1988-01-01

    A systematic analysis of the French interrogative focuses on the distinction between the syntactic processes (identification of question words, interrogative phrase preposing, and rules of question formation) and phonological processes (intonation patterns) that characterize questions in French. (Author/MSE)

  15. Pour une didactique du francais langue et litterature etrangeres (Toward a Didactic of French Second Language and Literature).

    ERIC Educational Resources Information Center

    Oriol-Boyer, Claudette

    1990-01-01

    A method of second-language instruction that acknowledges and reinforces the connection between ordinary and artistic uses of language is discussed. The theory, rationale, methods, and some sample activities for the approach are outlined. (MSE)

  16. Conceptual design of a polarized 3He neutron spin filter for polarized neutron spectrometer POLANO at J-PARC

    NASA Astrophysics Data System (ADS)

    Ino, T.; Ohoyama, K.; Yokoo, T.; Itoh, S.; Ohkawara, M.; Kira, H.; Hayashida, H.; Sakai, K.; Hiroi, K.; Oku, T.; Kakurai, K.; Chang, L. J.

    2016-04-01

    A 3He neutron spin filter (NSF) has been designed for a new polarized neutron chopper spectrometer called the Polarization Analysis Neutron Spectrometer with Correlation Method (POLANO) at the Materials and Life Science Experimental Facility of the Japan Proton Accelerator Research Complex. It is designed to fit in a limited space on the spectrometer as an initial neutron beam polarizer and is polarized in situ by spin exchange optical pumping. This will be the first generation 3He NSF on POLANO, and a polarized neutron beam up to 100 meV with a diameter of 50 mm will be available for research on magnetism, hydrogen materials, and strongly correlated electron systems.

  17. Status of the RF-driven H{sup −} ion source for J-PARC linac

    SciTech Connect

    Oguri, H. Ohkoshi, K.; Ikegami, K.; Takagi, A.; Asano, H.; Ueno, A.; Shibata, T.

    2016-02-15

    For the upgrade of the Japan Proton Accelerator Research Complex linac beam current, a cesiated RF-driven negative hydrogen ion source was installed during the 2014 summer shutdown period, with subsequent operations commencing on September 29, 2014. The ion source has been successfully operating with a beam current and duty factor of 33 mA and 1.25% (500 μs and 25 Hz), respectively. The result of recent beam operation has demonstrated that the ion source is capable of continuous operation for approximately 1100 h. The spark rate at the beam extractor was observed to be at a frequency of less than once a day, which is an acceptable level for user operation. Although an antenna failure occurred during operation on October 26, 2014, no subsequent serious issues have occurred since then.

  18. First demonstration of an emulsion multi-stage shifter for accelerator neutrino experiments in J-PARC T60

    NASA Astrophysics Data System (ADS)

    Yamada, K.; Aoki, S.; Cao, S.; Chikuma, N.; Fukuda, T.; Fukuzawa, Y.; Gonin, M.; Hayashino, T.; Hayato, Y.; Hiramoto, A.; Hosomi, F.; Inoh, T.; Iori, S.; Ishiguro, K.; Kawahara, H.; Kim, H.; Kitagawa, N.; Koga, T.; Komatani, R.; Komatsu, M.; Matsushita, A.; Mikado, S.; Minamino, A.; Mizusawa, H.; Matsumoto, T.; Matsuo, T.; Morimoto, Y.; Morishima, K.; Morishita, M.; Naganawa, N.; Nakamura, K.; Nakamura, M.; Nakamura, Y.; Nakano, T.; Nakatsuka, Y.; Nakaya, T.; Nishio, A.; Ogawa, S.; Oshima, H.; Quilain, B.; Rokujo, H.; Sato, O.; Seiya, Y.; Shibuya, H.; Shiraishi, T.; Suzuki, Y.; Tada, S.; Takahashi, S.; Yokoyama, M.; Yoshimoto, M.

    2017-06-01

    We describe the first ever implementation of a clock-based, multi-stage emulsion shifter in an accelerator neutrino experiment. The system was installed in the neutrino monitoring building at the Japan Proton Accelerator Research Complex as part of a test experiment, T60, and stable operation was maintained for a total of 126.6 days. By applying time information to emulsion films, various results were obtained. Time resolutions of 5.3-14.7 s were evaluated in an operation spanning 46.9 days (yielding division numbers of 1.4-3.8×105). By using timing and spatial information, reconstruction of coincident events consisting of high-multiplicity and vertex-contained events, including neutrino events, was performed. Emulsion events were matched to events observed by INGRID, one of the on-axis near detectors of the T2K experiment, with high reliability (98.5%), and hybrid analysis of the emulsion and INGRID events was established by means of the multi-stage shifter. The results demonstrate that the multi-stage shifter can feasibly be used in neutrino experiments.

  19. Magnetic field imaging of a model electric motor using polarized pulsed neutrons at J-PARC/MLF

    NASA Astrophysics Data System (ADS)

    Hiroi, K.; Shinohara, T.; Hayashida, H.; Parker, J. D.; Oikawa, K.; Harada, M.; Su, Y.; Kai, T.

    2017-06-01

    We have been developing a magnetic field imaging method using polarized pulsed neutrons for quantitative evaluation of magnetic fields in industrial equipment. To reduce the power loss of these products, it is important to quantitatively evaluate the distribution of not only strength but also direction of the internal field. In this study, we attempted to visualize the directional distribution of a magnetic field in a model electric motor. Because of the limited wavelength range that we could use in the present analysis, the polarization distribution image of the model motor was confirmed to reflect the directional distribution of the magnetic field outside the motor. It was also clarified that usage of shorter wavelength neutrons would enable us to visualize the field inside the motor. Then polarized neutron imaging was found to be a potentially powerful method for observing the directional distribution of the driving field of a rotating motor.

  20. 9 CFR 151.9 - Recognized breeds and books of record.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    .... Libertador General San Martin 4101, Capital Federal, Republica Argentina. 2206 ......do Stud Book Francais... Federal, Republica Argentina. 2226 ......do American Stud Book. (Recognition of this book will be...

  1. Cadre conceptuel des programmes de francais au secondaire: lignes directrices. Immersion (Conceptual Framework for French Programs at the Secondary Level: Guidelines. Immersion).

    ERIC Educational Resources Information Center

    Bourque, Francine; And Others

    Conceptual guidelines for the design of new secondary school French second language programs are outlined, in response to the need for an instructional model to accommodate Alberta's increasing anglophone enrollment in French immersion programs. The first section chronicles the evolution of the concept of language and second language instructional…

  2. Problemes d'analyse du discours. Essai de description du discours francais sur la Chine (Problems in Discourse Analysis. An Attempt to Describe French Discourse on China).

    ERIC Educational Resources Information Center

    Marindin, Jean-Marie

    1979-01-01

    The following topics are developed: (1) the problematic aspect of the analysis of French discourse, an introduction to methods, theories and applications; (2) the proposals of M. Pecheux; (3) precisions to render operative definitions derived in the proposals; (4) the Macciocchi manner of speaking; and (5) the Peyrefitte manner of speaking. (AMH)

  3. "Peau d'Ane" videodisque interactif de francais, langue etrangere ("Donkey's Hide," an Interactive Videodisc in French as a Second Language).

    ERIC Educational Resources Information Center

    Garrigues, Mylene

    1985-01-01

    The characteristics of videodisc technology are outlined, and a project undertaken to create an interactive videodisc for French language instruction is described, including the efforts to eliminate physical barriers between the computer and the user, pedagogical strategy and material, programing technicalities, and other details of production.…

  4. Recherche empirique sur l'effet de la musique dans l'enseignement suggestopedique du francais (Empirical Research on the Effect of Music in Suggestopedic French Instruction).

    ERIC Educational Resources Information Center

    Schiffler, Ludger

    1986-01-01

    A study of the effectiveness of music techniques in French second-language instruction using the suggestopedic approach is reported. The study attempts to control for variations commonly found in experimental conditions. (MSE)

  5. La place de la negation syntaxique en francais (The Place of Syntactic Negation in French). Montreal Working Papers in Linguistics, Vol. 2.

    ERIC Educational Resources Information Center

    Paradis, Michel

    This paper is a syntactic analysis of standard French negation. The following expressions are described in detail: (1)ne...pas(point), (2)nullement (aucunement), (3)plus, (4)jamais, (5)pas encore, (6)guere, (7)rien, (8)personne, (9)aucun(e), (10)nul(le), (11)ni...ni..., (12)nulle part, (13)que, (14)pas un(e), (15)nul. The negative expressions are…

  6. Intonation et syntaxe chez l'enfant francais a partir de dix-huit mois (Intonation and Syntax in the French Child from the Age of 18 months)

    ERIC Educational Resources Information Center

    Leroy, Christine

    1975-01-01

    This article reports on a study to determine the role of intonation in language acquisition. Related studies are mentioned. Research methods for the study are outlined and two case studies are reviewed. Conclusions show that adult-child interaction influences not only the child's use of intonation but also his acquisition of syntax. (Text is in…

  7. Synthese et methodologie des moyens de correction phonetique du "R" francais enseigne aux anglophones (Methods of Correcting the Pronunciation of the French "R" for English Speakers).

    ERIC Educational Resources Information Center

    Lebel, Jean-Guy

    The present work begins with a phonetic description of the acceptable French /R/ and descriptions of several allophones of English /R/ which must be avoided while learning the French. Various theories are discussed concerning the relationship between the position of the /R/ in an utterance and the difficulty students have in pronouncing it…

  8. L'Alternance entre les auxiliaires "avoir" et "etre" en francais parle a Montreal (Alternation between the Auxiliaries "Avoir" and "Etre" in Spoken French in Montreal)

    ERIC Educational Resources Information Center

    Sankoff, Gillian; Thibault, Pierrette

    1977-01-01

    A study of the spoken French of 120 residents of Montreal. The researchers were interested in the linguistic and social factors influencing the use of "avoir" and "etre." Results show that this usage corresponds to a tendancy to regularize conjugations. (Text is in French.) (AMH)

  9. Francais langue seconde: Les apprenants face au discours didactique oral. (French as a Second Language: How Learners Deal with Didactic Oral Discourse).

    ERIC Educational Resources Information Center

    Cabut, Helene

    As part of a course in French for foreign post-graduate engineering students, recordings of a series of lectures in information science were used to highlight some of the problems involved in the comprehension of spoken scientific discourse. In order to observe whether repetitions within oral discourse were perceived as such by non-French speaking…

  10. Les examens de francais dans le second cycle en Grande-Bretagne (French Examinations in the Second Cycle in Great Britain)

    ERIC Educational Resources Information Center

    Nott, David

    1978-01-01

    A description of the status of foreign language instruction and testing in the context of the changing state of education. The content of Second Cycle French programs, a critique of French examinations and some samples of tests which point to change are discussed. (Text is in French.) (AMH)

  11. Vers une autonomie croissante de l'apprenant du francais langue etrangere (Toward an Increasing Autonomy of the French as a Foreign Language Learner)?

    ERIC Educational Resources Information Center

    Hoeflaak, Arie; Verloop, Nico

    2000-01-01

    Investigates characteristics of spoken French texts. Experience teaching French as a foreign language has revealed that some university students, even at a relatively advanced level, have difficulty understanding the news on Radio France International. Suggests that three characteristics of the spoken news program that may cause students…

  12. Le Rythme. Son enseignement et son role dans la correction phonetique du francais (The Teaching and Role of Rhythm in the Correction of French Pronunciation).

    ERIC Educational Resources Information Center

    Lebel, Jean-Guy

    Students of French learn to pronounce the syllables of the same rhythmic group with the same stress and the same intonation while lengthening slightly only the last syllable uttered. Several techniques designed to help students acquire correct French rhythm patterns are described here. They include: (1) counting aloud, (2) syllable division, (3)…

  13. "-age" dans le systeme suffixal du francais quebecois ("-age" in the Suffix System of Quebec French). Montreal Working Papers in Linguistics, Vol. 4.

    ERIC Educational Resources Information Center

    Pupier, Paul; And Others

    This study relates the suffix "-age" to "-able,""-eux,""-ment,""-Xtion," and "-ure" in Quebec French. Morphologically, some "-age" suffixals which can be denominal in Quebec French can only be deverbal in European French. Semantically, "-age" deverbals are subdivided…

  14. Francais fonctionnel et travailleurs etrangers: Experiences d'oral avec des debutants (Functional French and Foreign Workers: Experiments in Spoken Languages with Beginners). Melanges pedagogiques.

    ERIC Educational Resources Information Center

    Pieron, C.

    Teaching functional French is discussed with instructors of groups of foreign workers in mind. It takes as its starting point two "modules" for teaching French ("the highway code at driving school" and "starting and keeping small talk going") and uses them to exemplify some of the difficulties involved in the development and classroom use of…

  15. L'apprentissage de la lecture du francais scientifique et la langue maternelle (The Relationship between a Speaker's Native Language and Learning to Read Technical French).

    ERIC Educational Resources Information Center

    Ulijn, Jan

    Two questions arise from attempts to develop reading comprehension in scientific French: (1) should the concentration be mainly on vocabulary, or on grammar as well, and if so, what aspect of grammar; and (2) should the students' native language be taken into account, and if so, in what way: by translating, or through a systematic comparison of…

  16. Le vocabulaire disponible du francais, Tome II. Vocabulaire disponible des enfants acadiens (The Working French Vocabulary, Volume 2. Working Vocabulary of Acadian Children).

    ERIC Educational Resources Information Center

    Mackey, William F.; And Others

    The second of a two-volume study of the relative accessibility of French vocabulary in French-speaking Acadia, this study presents statistical data concerning the degree of difficulty of recall of vocabulary related to 16 fundamental centers of interest found in normal conversation. The data are derived from responses of 700 students ranging from…

  17. "Peau d'Ane" videodisque interactif de francais, langue etrangere ("Donkey's Hide," an Interactive Videodisc in French as a Second Language).

    ERIC Educational Resources Information Center

    Garrigues, Mylene

    1985-01-01

    The characteristics of videodisc technology are outlined, and a project undertaken to create an interactive videodisc for French language instruction is described, including the efforts to eliminate physical barriers between the computer and the user, pedagogical strategy and material, programing technicalities, and other details of production.…

  18. Synthese et methodologie des moyens de correction phonetique du "R" francais enseigne aux anglophones (Methods of Correcting the Pronunciation of the French "R" for English Speakers).

    ERIC Educational Resources Information Center

    Lebel, Jean-Guy

    The present work begins with a phonetic description of the acceptable French /R/ and descriptions of several allophones of English /R/ which must be avoided while learning the French. Various theories are discussed concerning the relationship between the position of the /R/ in an utterance and the difficulty students have in pronouncing it…

  19. La maternelle--francais langue premiere: Manuel a l'intention des parents (Pre-School--French as a Native Language: Parents' Manual).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This manual, intended for the parents of new pre-school students, presents information on the organization and curriculum of Alberta's French-language pre-school programs for native speakers of French. Written from the point of view of a fictional pre-school teacher, the manual responds to parents' frequently asked questions on topics such as…

  20. Modeles de rendement langagier--Francais langue premiere: 8e annee (Models of Linguistic Production--French as a Native Language: 8th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for eighth grade students…

  1. Modeles de rendement langagier--Francais langue premiere: 9e annee (Models of Linguistic Production--French as a Native Language: 9th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for ninth grade students…

  2. Propositions d'Outils pour une Grammaire du Francais Langue Etrangere (Suggestions for Tools for a Grammar of French as a Foreign Language)

    ERIC Educational Resources Information Center

    Lamy, Andre

    1975-01-01

    Recommends some deformalization of instruction, without rendering it simplistic, by cultivation of students' discrimination of the appropriateness of grammatical elements, at a level where the student has already accumulated examples of structures and situations in the language. Substantial examples are provided. (Text is in French.) (MSE)

  3. Analyse des erreurs et grammaire generative: La syntaxe de l'interrogation en francais (Error Analysis and Generative Grammar: The Syntax of Interrogation in French).

    ERIC Educational Resources Information Center

    Py, Bernard

    A progress report is presented of a study which applies a system of generative grammar to error analysis. The objective of the study was to reconstruct the grammar of students' interlanguage, using a systematic analysis of errors. (Interlanguage refers to the linguistic competence of a student who possesses a relatively systematic body of rules,…

  4. La comprehension du francais parle au niveau avance: un exemple de test (Comprehension of Spoken French at the Advanced Level: A Test Sample).

    ERIC Educational Resources Information Center

    Mauriac, Paul

    1980-01-01

    The use of taped radio programs is suggested for testing advanced level French comprehension. In the testing technique described less attention is given to program content than to style and language usage. A sample test is presented. (MSE)

  5. ONU Geneve: quel avenir pour le francais? Silence, on coule! (ONU Geneva: What Future for French? Quiet, We're Sinking!)

    ERIC Educational Resources Information Center

    Lebreton, Jean-Michel; And Others

    1986-01-01

    Two articles address change and conflict concerning the French language. One discusses the comparative roles of English and French at the United Nations office in Geneva; the other is in response to the opinions of Philippe de Saint Robert on the need to protect French from change. (MSE)

  6. La francophonie dans les manuels de francais langue seconde: apports et limites (Francophony in French Second Language Textbooks: Contributions and Limitations).

    ERIC Educational Resources Information Center

    Fleig-Hamm, Christiane

    1998-01-01

    This study examined representation of francophone regions other than France in readings and activities in French second-language textbooks published since 1995. The model of representation used shows the richness and variety of the cultures, contains no inaccurate information, and gives a realistic portrayal devoid of colonialistic and…

  7. Des stereotypes de la France et des Francais chez des etudiants mexicains (Some Stereotypes of France and the French Held by Mexican Students).

    ERIC Educational Resources Information Center

    Pugibet, Veronica

    1983-01-01

    The origins and functions of stereotypes are discussed, a classroom study of Mexican students' perceptions of the French and French culture based on their responses to French advertising and cartoons is reported, and implications for instruction and teacher behavior to change existing stereotypes are outlined. (MSE)

  8. A propos de quelques experiences de francais fonctionnel en milieu hispanaphone (A Commentary on Experiments in Functional French in a Spanish-Speaking Milieu)

    ERIC Educational Resources Information Center

    Baltzer, Francois

    1978-01-01

    A discussion of the adaptation of audiovisual methods to respond to various specific needs in Mexico City. Some of the topics discussed are: meeting needs of people involved in special fields, particularly science, technology and economics; and the use of television for functional French instruction. (AMH)

  9. Les examens de francais dans les universites populaires en R.F.A. (French Examinations in People's Universities in the Federal Republic of Germany)

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The Certificate of the People's Universities is an examination organized in different European countries. The students are generally adults in evening courses. A description of the system in Germany is given; and principles of the examination, test content, and educational perspectives are discussed. References are included. (Text is in French.)…

  10. Connaissance et Usage d'Anglicismes par des Francais de Paris (Knowledge and Usage of Anglicisms by French People in Paris)

    ERIC Educational Resources Information Center

    Cartier, Alice

    1977-01-01

    A synthesis of a research project treating the relationship between the comprehension of English words, the ability to use them and their actual usage by members of various social groups in Paris. Topics covered are: methodology, classification of words, reactions of informants and interpretation of data. (Text is in French.) (AMH)

  11. Images de la societe dans le cinema francais des dix dernieres annees (Images of Society in French Film in the Last Ten Years).

    ERIC Educational Resources Information Center

    Esteve, Michel

    1980-01-01

    It is proposed that film has become a mirror of French society and of social change in France since 1968. It reflects changes in life-style, evolution of morals, fluctuations in fashion, and changes in urban and rural landscapes. However, it rarely questions society seriously. (MSE)

  12. Le francais parle dans la ville de Quebec: une etude sociolinguistique (The Spoken French in the City of Quebec: A Sociolinguistic Study). Publication G-1.

    ERIC Educational Resources Information Center

    Deshaies, Denise

    This study is divided into two major sections. The first, the study of language in a sociolinguistic perspective, includes: (1) an analysis of the attitudes associated with linguistic variation, and a review of (2) studies conducted in French Quebec, (3) the linguistic and cultural deficit theories, (4) the theory of cross-linguistic and…

  13. La francophonie dans les manuels de francais langue seconde: apports et limites (Francophony in French Second Language Textbooks: Contributions and Limitations).

    ERIC Educational Resources Information Center

    Fleig-Hamm, Christiane

    1998-01-01

    This study examined representation of francophone regions other than France in readings and activities in French second-language textbooks published since 1995. The model of representation used shows the richness and variety of the cultures, contains no inaccurate information, and gives a realistic portrayal devoid of colonialistic and…

  14. Systeme des fautes et correction phonetique des Anglais qui apprennent le francais (System of Errors and Phonetic Correction of English Speakers Learning French)

    ERIC Educational Resources Information Center

    Lebrun, Claire

    1975-01-01

    This article provides the results of an investigation of the system of pronunciation faults of English speakers learning French, and describes means of correction based on the verbo-tonal system. (Text is in French.) (CLK)

  15. L'interjection: son role et son impact dans une classe de francais (Interjection: Its Role and Impact in a French Class).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1983-01-01

    It is suggested that students of French should be exposed to the richness of a living language by introducing them to all possible outputs and underlining the importance of the interjection in oral discourse. A number of common interjections and usage situations are outlined, and some teaching methods are discussed. (MSE)

  16. Gestion de stockage d'energie thermique d'un parc de chauffe-eaux par une commande a champ moyen

    NASA Astrophysics Data System (ADS)

    Bourdel, Benoit

    In today's energy transition, smart grids and electrical load control are very active research fields. This master's thesis is an offshoot of the SmartDesc project which aims at using energy storage capability of electric household appliances, such as water heaters and electric heaters to mitigate the fluctuations of system loads and renewable generation. The smartDESC project aims at demonstrating that the mean field game theory (MFG), as new mathematical theory, can be used to convert and control water heaters (and possibly space heater) into smart thermal capacities. Thus, a set of "modules" has been developed. These modules are used to generate the optimal control and locally interpret it, to simulate the water-heater thermophysics or water draw event, or to virtualize a telecommunication mesh network. The different aspects of the project have been first studied and developed separately. During the course of this master's research, the modules have been integrated, tested, interfaced and tuned in a common simulator. This simulator is designed to make complete electrical network simulations with a multi-scale approach (from individual water heater to global electric load and production). Firstly, the modules are precisely described theoretically and practically. Then, different types of control are applied to an uniform population of houses fitted with water heaters and controllers. The results of these controls are analysed and compared in order to understand their strengths and weaknesses. Finally, a study was conducted to analyse the resilience of a mean field control. This report demonstrates that mean field game theory in coordination with a system level aggregate model based optimization program, is able to effectively control a large population of water heaters to smooth the overall electrical load. This control offers good resilience to unforeseen circumstances that can disrupt the network. It is also demonstrated that a mean field control is able to absorb fluctuations due to wind power production. Thus, by reducing the variability of the residential sector's electrical charge, the mean field control plays a role in increasing power system stability in the face of high levels of renewable energy penetration. The next stage of smartDESC project is now to set up an intelligent electric water heater prototype. This prototype, in progress since January 2016 at Ecole Polytechnique in Montreal, is aimed at proving concretely the theories developed in the project.

  17. Parks and People. A European Conference for Naturparke Parcs Naturels/National Parks (U.K.) and Equivalent Reserves (Losehill Hall, Castleton, England, September 25-29, 1978).

    ERIC Educational Resources Information Center

    Youel, Alex J.

    Presented are the proceedings of the European Conference for National Parks and Equivalent Reserves held at the Peak National Park Study Centre, Castleton, England in 1978. Thirty-nine representatives from 10 countries focused on the relationship between the parks and the people connected with them (the local people, the visitors, and the park…

  18. Investigation of the Long-Term Performance of the 324 MHz Klystrons for Achieving the Efficient Operation of the Linac at J-PARC

    NASA Astrophysics Data System (ADS)

    Hori, T.; Shinozaki, S.; Chishiro, E.; Sato, F.; Kawamura, M.; Futatsukawa, K.; Fukui, Y.; Oguri, H.

    As a part of the researches of the reliability and life time of klystrons, the cathode performance test of 324 MHz klystrons operated for 32000 hours on line has been performed at the klystron test stand. The experimental results coincide approximately with the data both reported in the literature for the cathode performance and the one obtained from the data base of RF data acquisition system. In this test, two parameters such as klystron beam perveance and knee-point were used to investigate the emission performance. It turned out that klystron beam perveance is most suitable parameter for understanding the klystron performance under operating condition on line.

  19. Parks and People. A European Conference for Naturparke Parcs Naturels/National Parks (U.K.) and Equivalent Reserves (Losehill Hall, Castleton, England, September 25-29, 1978).

    ERIC Educational Resources Information Center

    Youel, Alex J.

    Presented are the proceedings of the European Conference for National Parks and Equivalent Reserves held at the Peak National Park Study Centre, Castleton, England in 1978. Thirty-nine representatives from 10 countries focused on the relationship between the parks and the people connected with them (the local people, the visitors, and the park…

  20. Physical activity and the rejuvenation of Connswater (PARC study): protocol for a natural experiment investigating the impact of urban regeneration on public health

    PubMed Central

    2013-01-01

    Background There is a dearth of evidence regarding the impact of urban regeneration projects on public health, particularly the nature and degree to which urban regeneration impacts upon health-related behaviour change. Natural experiment methodology enables comprehensive large-scale evaluations of such interventions. The Connswater Community Greenway in Belfast is a major urban regeneration project involving the development of a 9 km linear park, including the provision of new cycle paths and walkways. In addition to the environmental improvements, this complex intervention involves a number of programmes to promote physical activity in the regenerated area. The project affords a unique opportunity to investigate the public health impact of urban regeneration. Methods/Design The evaluation framework was informed by the socio-ecological model and guided by the RE-AIM Framework. Key components include: (1) a quasi-experimental before-and-after survey of the Greenway population (repeated cross-sectional design), in tandem with data from a parallel Northern Ireland-wide survey for comparison; (2) an assessment of changes in the local built environment and of walkability using geographic information systems; (3) semi-structured interviews with a purposive sample of survey respondents, and a range of community stakeholders, before and after the regeneration project; and (4) a cost-effectiveness analysis. The primary outcome is change in proportion of individuals identified as being regularly physically active, according to the current UK recommendations. The RE-AIM Framework will be used to make an overall assessment of the impact of the Greenway on the physical activity behaviour of local residents. Discussion The Connswater Community Greenway provides a significant opportunity to achieve long-term, population level behaviour change. We argue that urban regeneration may be conceptualised meaningfully as a complex intervention comprising multiple components with the potential, individually and interactively, to affect the behaviour of a diverse population. The development and implementation of our comprehensive evaluation framework reflects this complexity and illuminates an approach to the empirical, rigorous evaluation of urban regeneration. More specifically, this study will add to the much needed evidence-base about the impact of urban regeneration on public health as well as having important implications for the development of natural experiment methodology. PMID:24103381

  1. The Physical Activity and Redesigned Community Spaces (PARCS) Study: Protocol of a natural experiment to investigate the impact of citywide park redesign and renovation.

    PubMed

    Huang, Terry T K; Wyka, Katarzyna E; Ferris, Emily B; Gardner, Jennifer; Evenson, Kelly R; Tripathi, Devanshi; Soto, Gabriel Martinez; Cato, Matthew S; Moon, Jon; Wagner, Julia; Dorn, Joan M; Catellier, Diane J; Thorpe, Lorna E

    2016-11-14

    The built environment plays a critical role in promoting physical activity and health. The association between parks, as a key attribute of the built environment, and physical activity, however, remains inconclusive. This project leverages a natural experiment opportunity to assess the impact of the Community Parks Initiative (CPI), a citywide park redesign and renovation effort in New York City, on physical activity, park usage, psychosocial and mental health, and community wellbeing. The project will use a longitudinal design with matched controls. Thirty intervention park neighborhoods are socio-demographically matched to 20 control park neighborhoods. The study will investigate whether improvements in physical activity, park usage, psychosocial and mental health, and community wellbeing are observed from baseline to 3 years post-renovation among residents in intervention vs. control neighborhoods. This study represents a rare opportunity to provide robust evidence to further our understanding of the complex relationship between parks and health. Findings will inform future investments in health-oriented urban design policies and offer evidence for addressing health disparities through built environment strategies.

  2. Le Developpement du francais oral soutenu par l'analyse du langage, 3e-6e annee (The Development of Sustained Oral French through Language Analysis, Grades 3-6). Serie: Le Francais a l'ecole primaire. Documentation pedagogique numero 9.

    ERIC Educational Resources Information Center

    Ostiguy, Luc; Gagne, Gilles

    An approach to elementary school French language instruction emphasizes sustained oral language through language analysis. The guide is intended for teachers of grades 3-6. It contains an introductory section, an explanation of the approach, a brief discussion of the linguistic content of oral language instruction, and four communicative classroom…

  3. Le Developpement du francais oral soutenu par l'analyse du langage, 3e-6e annee (The Development of Sustained Oral French through Language Analysis, Grades 3-6). Serie: Le Francais a l'ecole primaire. Documentation pedagogique numero 9.

    ERIC Educational Resources Information Center

    Ostiguy, Luc; Gagne, Gilles

    An approach to elementary school French language instruction emphasizes sustained oral language through language analysis. The guide is intended for teachers of grades 3-6. It contains an introductory section, an explanation of the approach, a brief discussion of the linguistic content of oral language instruction, and four communicative classroom…

  4. La theorie autrement (Theory in Another Light).

    ERIC Educational Resources Information Center

    Bertocchini, Paola; Costanzo, Edwige

    1985-01-01

    Outlines a technique using articles from "Le Francais dans le Monde" to teach reading comprehension and theory simultaneously to teachers of French as a second language. Describes a program in Italy using this approach. (MSE)

  5. Alpha One Foundation

    MedlinePlus

    Languages French (Francais) German (Deutsch) Italian (Italiano) Spanish (Español) Portuguese (Portugues) Swedish (Svenska) Donate One Time Monthly Keep In Touch | About Us | Contact Us | What is the Alpha-1 ...

  6. Visual Performance on the Small Letter Contrast Test: Effects of Aging, Low Luminance and Refractive Error

    DTIC Science & Technology

    2000-08-01

    within each group and between groups. Methods : Results and Discussion: The aviation group consisted of 123 aviators and aircrew, ages 22 to 66, with... Francais D will more significantly affect performance under Ophtalmologie 19(4): 271-7.

  7. Control of Large-Scale Civil Conflicts in Democratic Nigeria

    DTIC Science & Technology

    2007-11-02

    country. On the 7 other hand, the federal government handles the lucrative taxes from imports, customs, excises , business and mining. The states generate...Adisa (Ibadan, Nigeria: Institut Francais de Recherche en Afrique , 1994), 115. 8 Isaac Olawale Albert, Introduction to Third-Party Intervention in...Institut Francais de Recherche en Afrique , 2001),3. 10 Isaac Olawale Albert, Introduction to Third-Party Intervention in Community Conflicts (Ibadan

  8. Missile Defensive Systems and the Civil Reserve Air Fleet

    DTIC Science & Technology

    2009-02-12

    projection is with anti-access tactics, specifically port denial. The most effective methods of port denial available to a weaker enemy are weapons...Christopher Bolkom, Bartholomew Elias, and Andrew Feickert, “MANPADS Threat to Commercial Aviation” (lecture, Centre francais sur les Etats-Unis a l’IFRI, 12...MANPADS Threat to Commercial Aviation.” Lecture. Centre francais sur les Etats-Unis a l’IFRI, 12 March 2004. Buxbaum, Peter A. “From Factory to Foxhole

  9. Testing Lorentz Invariance with Laser-Cooled Cesium Atomic Frequency Standards

    NASA Technical Reports Server (NTRS)

    Klipstein, William M.

    2004-01-01

    This slide presentation reviews the Lorentz invariance testing during the proposed PARCS experiment. It includes information on the primary atomic reference clock in space (PARCS), cesium, laser cooling, and the vision for the future.

  10. Testing Lorentz Invariance with Laser-Cooled Cesium Atomic Frequency Standards

    NASA Technical Reports Server (NTRS)

    Klipstein, William M.

    2004-01-01

    This slide presentation reviews the Lorentz invariance testing during the proposed PARCS experiment. It includes information on the primary atomic reference clock in space (PARCS), cesium, laser cooling, and the vision for the future.

  11. Avez-vous vu la meme chose que les Francais? Stereotypes et documents authentiques video. (Did You See the Same Thing as the French? Stereotypes and Authentic Video Documents).

    ERIC Educational Resources Information Center

    Wilczynska, Weronika

    1990-01-01

    This discussion treats cultural stereotypes as a significant issue in second-language instruction, and examines the role of video documents from the mass media in helping students perceive and understand such stereotypes. (MSE)

  12. French registry of acute leukemia and myelodysplastic syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Groupe Francais de Morphologie Hematologique

    SciTech Connect

    Not Available

    1987-09-15

    During 1982 and 1983, 4496 new cases were recorded in the French Registry of acute leukemia and myelodysplastic syndromes by the French Group of Hematologic Morphology. This cooperative group associated members of 37 university centers spread throughout France; these centers handle the overwhelming majority of acute leukemias diagnoses. The cases were all classified according to FAB guidelines. Two thousand four hundred ninety-nine cases of acute myeloid leukemia were recorded, with similar total recruitment and distribution by cytologic subclass for both years. Hemogram data analysis revealed significant differences between different classes for certain parameters, particularly leukocytosis. A greater proportion of the acute myelogenous leukemias (AMLs) secondary to chemotherapy and/or radiotherapy (n = 145) were unclassifiable according to the French-American-British (FAB) system than the de novo AMLs (n = 1954). Eight hundred twenty cases of myelodysplastic syndromes were analyzed. Their frequency was underestimated due to optional reporting during the first year and the less favorable position of the university centers for recruiting these syndromes. The characteristics of the hemograms were established for acquired idiopathic sideroblastic anemia (n = 107), refractory anemia with excess blasts (RAEB) (n = 329), chronic myelomonocytic leukemia (n = 129) and RAEB in transformation (n = 65). Analysis of the 1177 acute lymphoblastic leukemias (ALLs) recorded showed good stability from one year to the next in terms of numbers of cases and distribution in the subclasses L1, L2, and L3. The distribution among these three subclasses by age also was determined. For L1 and L2 the hemogram data were examined separately for adults and children. The study of 74 cases of type L3 ALL enabled us to detail the hematologic presentation of this rare form of leukemia.

  13. Resultats de l'enquete nationale sur les programmes de formation des enseignants de francais langue seconde au Canada (Results of the National Study for Teacher Education Programs for French Second Language Teachers in Canada).

    ERIC Educational Resources Information Center

    Boutin, France; Chinien, Christian; Boutin, Jean-Luc

    The implications of Canada's national study of core French instruction for second language (L2) teacher education in that country are examined. Literature on the study's impact on language teaching philosophy and policy and on French immersion instruction is reviewed, and a survey of 36 Canadian schools of education is reported. The questionnaire…

  14. Une epreuve orale de francais en fin d'etudes de gestion. Construction et implications pedagogiques (An Oral French Exam at the End of a Marketing Program. Construction and Pedagogical Implications).

    ERIC Educational Resources Information Center

    Crawshaw, Robert H.

    1984-01-01

    An oral language test administered at the end of a four-year program combining business administration and French is described. The test consists of the formal presentation of a report including numbers, graphics, and text, a discussion of a theoretical issue, and interview. (MSE)

  15. "Travaillez, sinon vous serez orientes": essai sur les difficultes actuelles des colleges et lycees francais ("Work, Or You Will Be Counseled out of Education": Essay on the Current Difficulties of French Proprietary and Secondary Schools).

    ERIC Educational Resources Information Center

    Prost, Antoine

    1985-01-01

    The French situation, in which the proprietary and upper-level secondary schools may contain a large number of "high-risk" or marginally qualified students, and proposed solutions to the problem, are described and discussed. (MSE)

  16. Une epreuve orale de francais en fin d'etudes de gestion. Construction et implications pedagogiques (An Oral French Exam at the End of a Marketing Program. Construction and Pedagogical Implications).

    ERIC Educational Resources Information Center

    Crawshaw, Robert H.

    1984-01-01

    An oral language test administered at the end of a four-year program combining business administration and French is described. The test consists of the formal presentation of a report including numbers, graphics, and text, a discussion of a theoretical issue, and interview. (MSE)

  17. A propos d'une typologie des objectifs possibles d'un enseignement "du" francais aux adultes en formation (Concerning a Typology of Possible Objectives in Teaching French to Continuing Education Students).

    ERIC Educational Resources Information Center

    Mariet, Francois

    1977-01-01

    Proposes an approach to French language instruction which stresses themes, such as literature, law, economics, and management, rather than specific occupational levels, so as to respect the needs of adult continuing education students of all socioeconomic levels. (AM)

  18. La Presse francaise telle que la connaissent et l'ignorent les etudiants en francais aux Etats-Unis (What Students of French in the United States Know and Don't Know about the French Press).

    ERIC Educational Resources Information Center

    Mariet, Francois

    1985-01-01

    Reports and discusses results of a survey of French students in Middlebury College's summer language school concerning their knowledge about and interest in French newpapers and magazines and data on the circulation and readership of those publications, with emphasis on the importance of regional newspapers. (MSE)

  19. Enquete sur le langage de l'enfant francais: Transcriptions de conversations d'enfants de 9 ans (Investigation of the Language of French Children: Transcriptions of Conversations of 9-Year-Olds). Document No. 1.

    ERIC Educational Resources Information Center

    Leclercq, Janine, Comp.

    These transcriptions of children living in a suburb of Paris represent and illustrate linguistic behavior and interests of the average nine-year-old French child. Seventy-nine children in groups of three were recorded in 30-minute periods of free conversation and 10-minute periods of play. Analysis reveals more than 30 centers of interest which…

  20. Enquete sur le langage de l'enfant francais: Transcriptions de conversations d'enfants de 10 ans (Investigation of the Language of French Children: Transcriptions of Conversations of Ten-Year-Olds). Document No. 2.

    ERIC Educational Resources Information Center

    Leclercq, Janine, Comp.

    These transcriptions of conversation illustrate linguistic behavior and interests of the average ten-year-old French child. Patterned after a previously transcribed series of conversations of nine-year olds, the 14 dialogues in this collection serve as a linguistic corpus suitable for educational research and textbook development. A graphic code…

  1. Le langage des "gendarmes" et des "voleurs": etude comparative du vocabulaire de la pegre et de la police en francais et en anglais ("Cops" and "Robbers" Language: A Comparative Study of the Underworld and Police Vocabulary of French and English).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1981-01-01

    Discusses the meaning and origins of the word "argot," its cryptic character, and its function in a closed social group, focusing on a comparative description of the French and Anglo-American vocabulary of the underworld and the police. Comments on shared traits and provides an insight into the differences. (MES)

  2. Affirming Francophone Education: Foundations and Directions. A Framework for French First Language Education in Alberta = Affirmer l'education en francais langue premiere: fondements et orientations. Le cadre de l'education francophone en Alberta.

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This booklet presents a clear and succinct description of the educational needs of francophone students, families, and communities, and how this all fits into the constitutional requirements of Canada as directed by the 1982 Canadian Charter of Rights and Freedoms and all subsequent amendments and Canadian Supreme Court rulings. It identifies the…

  3. A propos d'une typologie des objectifs possibles d'un enseignement "du" francais aux adultes en formation (Concerning a Typology of Possible Objectives in Teaching French to Continuing Education Students).

    ERIC Educational Resources Information Center

    Mariet, Francois

    1977-01-01

    Proposes an approach to French language instruction which stresses themes, such as literature, law, economics, and management, rather than specific occupational levels, so as to respect the needs of adult continuing education students of all socioeconomic levels. (AM)

  4. Vingt-cinq ans dans l'evolution d'une politique de diffusion du francais (Twenty-Five Years in the Evolution of the Politics of the Diffusion of French).

    ERIC Educational Resources Information Center

    Boulanger, Lionel; Daniel, Pierre

    1984-01-01

    The theme of a conference in honor of the centennial of a famous French teaching institution was the 25-year French policy of spreading the French language internationally. Discussions focused on the cultural politics involved and their institutionalization, and the evolution of methods to carry out this policy through the medium of linguistic…

  5. De L'Economie des moyens linguistiques en francais et en anglais dans l'usage standard contemporain (On the Economy of Linguistic Means in French and English Standard Contemporary Usage).

    ERIC Educational Resources Information Center

    Calve, Pierre

    1989-01-01

    The conciseness and "ease of use" often attributed to North American English relative to French in standard contemporary usage is explained in terms of English morpho-syntactic structure and of the values of the classical norm and rhetoric affecting French. (Author/MSE)

  6. Le langage des "gendarmes" et des "voleurs": etude comparative du vocabulaire de la pegre et de la police en francais et en anglais ("Cops" and "Robbers" Language: A Comparative Study of the Underworld and Police Vocabulary of French and English).

    ERIC Educational Resources Information Center

    Brunet, Jean-Paul

    1981-01-01

    Discusses the meaning and origins of the word "argot," its cryptic character, and its function in a closed social group, focusing on a comparative description of the French and Anglo-American vocabulary of the underworld and the police. Comments on shared traits and provides an insight into the differences. (MES)

  7. Un gars, une fille: plaidoyer pour la culture avec un "petit c" dans un cours de francais languae etrangere (Un gars, une fille: Culture with a "Litte c" in a French as a econd Language Course).

    ERIC Educational Resources Information Center

    Black, Catherine

    2001-01-01

    Looks at the Quebecois TV show, "Un gars, Une fille" used in a university French course to teach the socio-cultural reality that underlies all linguistic utterances in a university-level French course. Attempts to identify what makes the show more authentic than videos and CD ROMs that accompany most language textbooks in French.…

  8. De L'Economie des moyens linguistiques en francais et en anglais dans l'usage standard contemporain (On the Economy of Linguistic Means in French and English Standard Contemporary Usage).

    ERIC Educational Resources Information Center

    Calve, Pierre

    1989-01-01

    The conciseness and "ease of use" often attributed to North American English relative to French in standard contemporary usage is explained in terms of English morpho-syntactic structure and of the values of the classical norm and rhetoric affecting French. (Author/MSE)

  9. Pour un contenu linguistique en oral au 2e cycle du primaire (Toward a Linguistic Oral Content in the Second Cycle of Primary School). Serie: Le Francais a l'ecole primaire. Recherches et essais, numero 11.

    ERIC Educational Resources Information Center

    Ostiguy, Luc; Gagne, Gilles

    It is proposed that linguistic oral content, or metalinguistics, be included in the curriculum of primary school francophone children. This content is not included in the functionally oriented official curriculum. The linguistic content proposed consists of a number of formal variants corresponding to non-formal stylistic markers and respecting…

  10. Avez-vous vu la meme chose que les Francais? Stereotypes et documents authentiques video. (Did You See the Same Thing as the French? Stereotypes and Authentic Video Documents).

    ERIC Educational Resources Information Center

    Wilczynska, Weronika

    1990-01-01

    This discussion treats cultural stereotypes as a significant issue in second-language instruction, and examines the role of video documents from the mass media in helping students perceive and understand such stereotypes. (MSE)

  11. Evaluation en francais de base: La production orale et ecrite, secondaire 1 et 4, 1993. Rapport sommaire (Basic French Assessment: Speaking and Writing Skills, Senior 1 and 4, 1993. Summary Report).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    The report, entirely in French, summarizes an assessment of the extent to which Manitoba schools are meeting the learning objectives for speaking and writing skills specified for senior (secondary) levels 1 and 4 in the basic French curriculum for the province. For each level and skill area, a random sample of students representing urban and rural…

  12. Evaluation en francais de base: La production orale et ecrite, secondaire 1 et 4, 1993. Rapport global (Basic French Assessment: Speaking and Writing Skills, Senior 1 and 4, 1993. Final Report).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    The report, entirely in French, details an assessment of the extent to which Manitoba schools are meeting the learning objectives for speaking and writing skills specified for senior (secondary) levels 1 and 4 in the basic French curriculum for the province. For each level and skill area, a random sample of students representing urban and rural…

  13. Modeles de rendement langagier: French Language Arts--7e annee. Francais langue seconde--immersion (Models of Linguistic Production--French as a Second Language/Immersion: 7th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. The task for seventh grade students…

  14. Bibliographie annotee 4-6--Francais langue seconde-immersion: Selection d'ouvrages de la litterature jeunesse (Annotated Bibliography 4-6--French as a Second Language-Immersion: Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This annotated bibliography of children's literature presents 74 books and stories that can be used in the classroom to introduce literature in French to children in fourth through sixth grades. The selected texts (51 titles in fiction and 23 titles in non-fiction) were chosen for their age-appropriate language and themes, as well as their…

  15. Modeles de rendement langagier: French Language Arts--8e annee. Francais langue seconde--immersion: (Models of Linguistic Production--French as a Second Language/Immersion: 8th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first and second language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out and evaluating their work. The task for eighth grade students…

  16. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Huitieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Eighth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for eighth-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  17. Bibliographie annotee 4-6--Francais langue premiere: Selection d'ouvrages de la litterature jeunesse (Annotated Bibliography 4-6--French as a Native Language: Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This annotated bibliography of children's literature presents 85 books and stories that can be used in the classroom to introduce literature in French to children in fourth through sixth grades. The selected texts (64 titles in fiction and 21 titles in non-fiction) were chosen for their age-appropriate language and themes, as well as their…

  18. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Septieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Seventh Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for seventh-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  19. Bibliographie Annotee M-3: Francais langue seconde--immersion. Selection d'ouvrages de la litterature enfantine (Annotated Bibliography M-3: French as a Second Language--Immersion. Selection of Works from Children's Literature).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    This annotated bibliography of children's literature presents over 150 books, stories and songs that can be used in the French language classroom to introduce literature in French to children in Kindergarten through third grade. The selected texts (97 titles in fiction and 62 titles in non-fiction) were chosen for their age-appropriate language…

  20. French Language Arts: Programme d'etudes par annee scolaire. Francais langue seconde--immersion. Neuvieme annee (French Language Arts: Yearly Curriculum. French as a Second Language--Immersion. Ninth Year).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for ninth-year French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  1. French Language Arts: Programme d'etudes du secondaire deuxieme cycle (10-12). Francais langue seconde--immersion (French Language Arts: High School Curriculum [10-12]. French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The report, entirely in French, describes Alberta's curriculum for high school French immersion, as revised in 1998. An introductory section offers background information on the curriculum revision, links between the core curriculum and French immersion, underlying principles of second language instruction, the revised curriculum's objectives and…

  2. Modeles de rendement langagier: French Language Arts--9e annee. Francais langue seconde--immersion (Models of Linguistic Production--French as a Second Language/Immersion: 9th Grade).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    Aligned with its 1998 standards for first- and second-language learning, Alberta Learning has published lesson plans that aim for a closer relationship between learning and evaluation. Each volume in this series presents a specific task for students that involves planning, carrying out, and evaluating their work. Three separate lesson plans in the…

  3. L'integration de la grammaire dans une approche interactive/experientielle en francais de base (The Integration of Grammar in an Interactive/Experiential Approach in Core French).

    ERIC Educational Resources Information Center

    Jean, Gladys

    1999-01-01

    Examines the integration of grammar into second-language instruction, specifically in core French courses in Canada. A brief overview of studies on this topic in different settings is followed by an attempt to demonstrate how the limited results of available studies can offer a starting point for finding solutions to the problems of integrating…

  4. Problemes poses par la mesure du rendement en francais des eleves franco-ontariens (Problems Posed by the Measurement of Proficiency in French Among Franco-Ontarian Students). Working Papers on Bilingualism, No. 16.

    ERIC Educational Resources Information Center

    Canale, Michael; Mougeon, Raymond

    This study examines the hypothesis that the French used by a large number of Franco-Ontarians represents a linguistic system (or several systems) that differs from Standard French. In addition, a review of previous research leads to the inverse hypothesis, that Ontarian French represents a body of different systems or sub-systems that are more or…

  5. Acquisition et enseignement du francais en situation minoritaire: le cas des Franco-ontariens (French Acquisition and Teaching in a Minority Situation: The Case of the Franco-Ontarians).

    ERIC Educational Resources Information Center

    Mougeon, Raymond; And Others

    1984-01-01

    A synthesis of research on the Franco-Ontarian school environment focuses on the maintenance of French by Franco-Ontarian students, their French language proficiency, and their native language instruction. The relevance of these issues in other French language minority settings is discussed. (MSE)

  6. Le francais parle: analyse des attitudes des adolescents de la ville de Quebec selon les classes sociales (Spoken French: An Analysis of the Attitudes of Adolescents in Quebec City according to Social Class).

    ERIC Educational Resources Information Center

    Noel, Daniele

    This is a report on a study of the attitudes of French-speaking young people, aged 10 to 17 years, toward French as it is spoken in two sectors of Quebec City. One sector, Sainte-Foy, is mainly upper middle class; the other, Saint-Sauveur, is economically and socially disadvantaged. The research was carried out on the basis of work in French and…

  7. Francais de base. Programme de 9 ans, materiel didactique: 4e, 5e et 6e annees (Core French. Nine-Year Study Program, Instructional Materials: 4th, 5th and 6th Grades).

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Bureau of French Education.

    Official instructional materials for the first three years (grades 4-6) of the Manitoba Department of Education's core French language program consist of units in geography, weather and calendars, holidays, and music designed for each of the three instructional levels. The units on geography focus on Manitoba and Canada. Units on the calendar and…

  8. Les Interferences Phonologiques du Francais et de l'Arabe - Le Temoignage des Ecrivains Maghrebins de Langue Francaise (Phonological Interferences between French and Arabic-- The Evidence from the Works of French Language Maghrebian Authors).

    ERIC Educational Resources Information Center

    Bastide, Mario

    1980-01-01

    Describes interferences from the phonologic system of Arabic in the French spoken by Arabs, using data recorded in the works of French authors from the Maghreb region. The analysis focuses on instances of interference concerning the perception and production of vowels, consonants, and syllables. (MES)

  9. Un corpus de francais parle. Montreal 84: Historique, methodes et perspectives de recherche (A Corpus of Spoken French. Montreal 84: History, Methods, and Perspectives of Research). Recherches Sociolinguistiques/1.

    ERIC Educational Resources Information Center

    Thibault, Pierrette; Vincent, Diane

    In 1984, a new corpus of spoken Quebecois French (Canada) was added to the existing data. In developing it, half of the native speakers participating in a 1971 study were re-interviewed, providing previously unavailable data on individual language development. The report describes in detail the sociolinguistic methodology used in developing the…

  10. Une verification de l'efficacite de la methode verbo-tonale: apprentissage du /y/ francais par des americanophones (Testing of the Efficiency of the Verbo-Tonal Method: The learning of the French /y/ by Speakers of American English)

    ERIC Educational Resources Information Center

    Fort, Paul; And Others

    1976-01-01

    This article describes a study designed to test the basic notions of the verbo-tonal method of error correction in second language learning, a method based on an awareness of the phonological system of the speaker's native language and its influence on the phonological system of the target language. (Text is in French.) (CLK)

  11. Project experimentale sur le bilinguisme Creole-Francais au niveau de l' enseignement primaire en Haiti (Experimental Project on Creole-French Bilingualism at the Primary Level in Haiti).

    ERIC Educational Resources Information Center

    de Ronceray, Hubert; Petit-Frere, Serge

    1975-01-01

    This is a progress report on the first year of an experimental bilingual education project for primary education in Haiti, sponsored by the Centre Haitien d' Investigation en Sciences Sociales (CHISS), The center's goal was to carry out a scientific project, to secure the facts from emotional and political prejudice. The point is to show the…

  12. Le lexique anglais-francais de l'industrie miniere de l'Office de la langue francaise (The English-French Lexicon of the Mining Industry prepared by the Office of the French Language)

    ERIC Educational Resources Information Center

    Rousseau, Louis-Jean

    1974-01-01

    This article describes research methods involved in compiling a lexicon of terms used in the mining industry. This consisted mainly in contrasting terms found in dictionaries with actual usage in spoken and written language. (Text is in French) (AM)

  13. L'alternance de code de deux enseignants de francais dans l'enseignement assiste par ordinateur de niveau debutant de langue seconde (Codeswitching in Two French as a Second Language Teachers, Beginning Level, in Computer Assisted Instruction).

    ERIC Educational Resources Information Center

    Taylor, Alan M.

    2002-01-01

    Investigates the code switching of two French teachers in a computer-assisted language learning (CALL) environment. Highlights the importance of the social dynamic and technical aspects of teachers' codeswitching behaviors. (Author/VWL)

  14. La Technologie au service de l'enseignement/apprentissage du francais langue seconde: Survol du projet RECALL, 1985-91 (Foreign Language Instruction and Learning and Educational Technology: Survey of Project RECALL, 1985-91).

    ERIC Educational Resources Information Center

    Ducretet, Marie-Paule; And Others

    1992-01-01

    A French curriculum development and research project at Erindale College (Canada), established in 1985, studies and initiates incorporation of computer technology into the University of Toronto French program. Specific objectives include evaluation and adaptation of existing software, development of an undergraduate course in computer applications…

  15. Bibliographie annotee 4-6--Francais langue seconde-immersion: Selection d'ouvrages de la litterature jeunesse. Supplement 2001 (Annotated Bibliography 4-6--French as a Second Language-Immersion: Selection of Works from Children's Literature. Supplement 2001).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    The document comprises 42 inserts to be included in the List of Books (4-6) for French as a Second Language (Immersion)--a selection of works of youth literature--published by Alberta Learning in 2000. Thirty-seven of the items appeal to the world of imagination and esthetics, and five items are of an informative nature. An appendix, entitled "How…

  16. Banque de strategies d'ecoute pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching listening skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It…

  17. Banque de strategies d'ecriture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for the Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, written in French, intended for the instruction of both French as a first language and French as a second language (immersion), provides a host of strategies for teaching writing skills in the classroom (grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the…

  18. Banque de strategies d'ecriture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Writing Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching writing skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  19. Banque de strategies de production orale pour un enseignement explicite de la 6e a la 12e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 6 through 12). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  20. Banque de strategies de lecture pour un enseignement explicite de la 6e a la 12e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 6 through 12. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in an immersion setting. It provides a host of strategies for teaching reading skills in the classroom in Grades 6 through 12. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  1. Banque de strategies de production orale pour un enseignement explicite de la 1re a la 7e annee: Expose et interaction. Document d'appui pour les programmes d'etudes de francais langue premiere et de francais langue seconde--immersion de 1998 (Interactive Oral Presentation Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion 1998).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching interactive oral presentation skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure,…

  2. Banque de strategies d'ecoute pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Listening Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton. Direction de l'education francaise.

    This teacher's guide is intended for the instruction of both French as a first language and French as a second language in immersion programs. It provides a host of strategies for teaching listening skills in the classroom in Grades 1 through 7. The first section is designed to bring the teacher's awareness to the training procedure. It discusses…

  3. Banque de strategies de lecture pour un enseignement explicite de la 1re a la 7e annee. Document d'appui pour les programmes d'etudes (1998) de francais langue premiere et de francais langue seconde--immersion (Reading Strategies for Specific Instruction in Grades 1 through 7. Guide in Support of Programs Teaching French as a First Language and French as a Second Language--Immersion).

    ERIC Educational Resources Information Center

    Northwest Territories Dept. of Education, Culture and Employment, Yellowknife.

    This teacher's guide, intended for the instruction of both French as a first language and French as a second language in an immersion setting, provides a host of strategies for teaching reading skills in the classroom (Grades 1 through 7). Section 1 is designed to bring the teacher's awareness to the training procedure, discussing the motivation…

  4. European Heritage Landscapes. An Account of the Conference on Planning and Management in European Naturparke/Parcs Naturels/National Parks (U.K.) and Equivalent Category "C" Reserves (Losehill Hall, Castleton, England, September 26-30, 1977).

    ERIC Educational Resources Information Center

    Smith, Roland

    Presented are the proceedings of the Conference on Planning and Management in European National Parks and equivalent Category "C" reserves held at the Peak National Park Study Center, Castleton, England, in 1977. Fifty-two representatives from 16 countries focused practical solutions to management and planning problems in national parks. (BT)

  5. European Heritage Landscapes. An Account of the Conference on Planning and Management in European Naturparke/Parcs Naturels/National Parks (U.K.) and Equivalent Category "C" Reserves (Losehill Hall, Castleton, England, September 26-30, 1977).

    ERIC Educational Resources Information Center

    Smith, Roland

    Presented are the proceedings of the Conference on Planning and Management in European National Parks and equivalent Category "C" reserves held at the Peak National Park Study Center, Castleton, England, in 1977. Fifty-two representatives from 16 countries focused practical solutions to management and planning problems in national parks. (BT)

  6. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (12th, Quebec City, Canada, March 26-27, 1998).

    ERIC Educational Resources Information Center

    Boissonneault, Chantal, Ed.

    Papers on language research include: "L'expression de l'opposition en Latin" ("The Expression of Opposition in Latin" (Claude Begin); "Le francais de l'Abitibi: characteristiques phonetiques et origine socio-geographique des locuteurs" ("The French of Abitibi: Phonetic Characteristics and Socio-Geographic Origin…

  7. Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

    ERIC Educational Resources Information Center

    Mazur, Gertrud S., Ed.

    The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic…

  8. Problemes en enseignement fonctionnel des langues (Problems in the Functional Teaching of Languages). Publication B-103.

    ERIC Educational Resources Information Center

    Alvarez, Gerardo, Ed.; Huot, Diane, Ed.

    Articles include: (1) "L'elaboration du materiel pedagogique pour des publics adultes" (The Elaboration of Teaching Materials for the Adult Public) by G. Painchaud-Leblanc, (2) "L'elaboration d'un programme d'etudes en francais langue seconde a partir des donnees recentes en didactique des langues" (The Elaboration of a Program…

  9. Indexing Price Trends of French Academic Books in the Humanities and Social Sciences.

    ERIC Educational Resources Information Center

    Austin, Ronald E.

    1994-01-01

    Provides data on price trends for French academic books in the humanities and social sciences for the years 1986-90 based on information from the "Bulletin Critique du Livre Francais," a monthly book-reviewing journal. A method for developing a price index for this material is demonstrated. (Contains eight references.) (LRW)

  10. Melanges Pedagogiques (Pedagogical Mixture), 1985.

    ERIC Educational Resources Information Center

    Melanges Pedagogiques, 1985

    1985-01-01

    The 1985 issue of the journal on second language teaching and learning contains four articles in French and three in English, including: "Lire et comprendre un texte informatif (Reading and understanding an Informative Text)" (Jacqueline Billant, Pascale Fade); "Les nouveaux diplomes de Francais Language Etrangere: Le D.E.L.F. et le…

  11. Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton.

    The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The…

  12. Paradoxes in French-Language Instruction: Recent Social and Historical Research on Literacy in France

    ERIC Educational Resources Information Center

    Rockwell, Elsie; Galvao, Ana Maria

    2012-01-01

    This essay on three recent books by outstanding scholars--"La raison scolaire" by Bernard Lahire, "Histoire de l'enseignement du francais du XVII[superscript e] au XX[superscript e] siecle" by Andre Chervel, and "L'ecole et la lecture obligatoire" by Anne-Marie Chartier--offers the opportunity to acquaint readers with…

  13. Actes des journees de linguistique: Colloque sur la recherche etudiante (Proceedings of the Linguistics Conference: Colloquium on Student Research) (Quebec, Canada, March 18-19, 1988).

    ERIC Educational Resources Information Center

    Lepage, Danielle, Ed.; Dominik, Annette, Ed.

    Presentations by students at a colloquium on student research on the occasion of the 50th anniversary of the University of Laval's Faculty of Letters, March 18-19, 1988, include: "Une enquete sur la qualite du francais ecrit au Quebec"; "Amenagement linguistique et neologie"; "Analyse syntaxique des 'arrets et retours' en…

  14. Multilingual Thesauri for the Modern World - No Ideal Solution?

    ERIC Educational Resources Information Center

    Jorna, Kerstin; Davies, Sylvie

    2001-01-01

    Discusses thesauri as tools for multilingual information retrieval and cross-cultural communication. Considers the need for multilingual thesauri and the importance of explicit conceptual structures, and introduces a pilot thesaurus, InfoDEFT (Information Deutsch-English-Francais Thesaurus), as a possible model for new online thesauri which are…

  15. Travaux du laboratoire de traitement du langage et de la parole (Laboratory Work in the Treatment of Language and Linguistics).

    ERIC Educational Resources Information Center

    Grosjean, Francois, Ed.

    1994-01-01

    Research papers on language and linguistics include: "Enchainement des mots et acces au lexique en francais" ("Word Order and Lexical Access in French") (Besson); "L'apport de la coarticulation dans la perception de consonnes occlusives et constrictives" ("The Contribution of Coarticulation to the Perception of…

  16. Discours oraux--discours ecrits: quelles relations? Actes du 4eme colloque d'orthophoine/logopedie (Neuchatel, 3-4 octobre, 1996) (Oral Discourse--Written Discourse: What Is the Relationship? Proceedings of the Colloquium on Speech Therapy (4th, Neuchatel, Switzerland, October 3-4, 1996).

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.

    1996-01-01

    Research papers on the relationship between oral and written language include: "Une distinction bien fragile: oral/ecrit" ("A Fragile Distinction: Oral/Written") (Francoise Gadet); "Oral et ecrit dans les representations des enseignants et dans les pratiques quotidiennes de la classe de francais" ("Oral and Written Language in Teachers'…

  17. Actes des Journees de linguistique (Proceedings of the Linguistics Conference) (15th, Quebec, Canada, March 15-16, 2001).

    ERIC Educational Resources Information Center

    Goulet, Marie-Josee, Ed.

    Papers on language research in this volume include the following: "Temporalite en francais de France. Differences dans la conceptualisation du temps et son expression dans un texte narratif oral" ("Differences in the Conceptualization of Time and Its Expression in Oral Narratives") (Natalia Dankova); "La traduction des…

  18. The Training of Modern Language Teachers in Various Countries. Collection d'"Etudes linguistiques," No. 20. Selected papers from the Association Internationale pour la Recherche et la Diffusion des Methodes Audio-Visuelles et Structuro-Globales Seminar (5th, August 27-September 1, 1973).

    ERIC Educational Resources Information Center

    Nivette, Jos, Ed.

    Selected papers that address theoretical and practical training of the modern language teacher and language teaching experiments in various countries are presented. Some of the articles included are the following: "Les problemes de la formation linguistique et pedagogique des professeurs de francais en Afrique Subsaharienne" (The…

  19. Melanges Pedagogiques (Pedagogical Mixture), 1986/87.

    ERIC Educational Resources Information Center

    Melanges Pedagogiques, 1987

    1987-01-01

    The 1986/87 issue of the journal on second language teaching and learning contains seven articles in French and four in English, including: "Learning How To Learn English"; "Socrate est-il un chat? Pratiquer le syllogisme pour apprendre a argumenter (Is Socrates a Cat? Practicing Syllogisms To Learn To Argue)"; "La production orale en francais des…

  20. Games for the Foreign Language Classroom.

    ERIC Educational Resources Information Center

    McMillan, Nancy; Madaras, Susan W.

    Two marketing games are described, "Le Marche Francais" and "El Mercado: The Mexican Market Comes to Life in the Spanish Classroom." Both are patterned after a published game entitled "Market: A Simulation Game." The adaptation in each instance relied on simplifying the original game and presenting it in a form understandable to middle school…

  1. L'enseignement de la langue maternelle dans les ecoles francaise aujourd'hui (The Teaching of the Native Language in French Schools Today).

    ERIC Educational Resources Information Center

    Marchand, Frank

    1979-01-01

    Describes the three methods of teaching French in elementary schools in France: the traditional, the Freinet, and the "Plan de renovation pour l'enseignement du francais." A description of a model for the l980s is given. Techniques influenced by sociolinguistics seem most suited to replace traditional methodology. (AMH)

  2. Games for the Foreign Language Classroom.

    ERIC Educational Resources Information Center

    McMillan, Nancy; Madaras, Susan W.

    Two marketing games are described, "Le Marche Francais" and "El Mercado: The Mexican Market Comes to Life in the Spanish Classroom." Both are patterned after a published game entitled "Market: A Simulation Game." The adaptation in each instance relied on simplifying the original game and presenting it in a form understandable to middle school…

  3. Actes du colloque: Tendances actuelles de la recherche sur la langue parlee (Conference Presentations: Current Trends in Research on Oral Language).

    ERIC Educational Resources Information Center

    Auger, Julie, Ed.

    Student papers presented at a sociolinguistics conference include: "La variation phonologique [d'une voyelle] a Hull"; "La force illocutoire des pronoms personnels 'je' et 'tu' en tant qu'insignes des places d'ou parlent les femmes et les hommes"; "L'emploi des modes indicatif et subjonctif dans le francais parle de la…

  4. EPA/IFP EUROPEAN WORKSHOP ON THE EMISSION ON NITROUS OXIDE FROM FOSSIL FUEL COMBUSTION

    EPA Science Inventory

    The report summarizes the proceedings of an EPA/Institut Francais du Petrole (IFP) cosponsored workshop addressing direct nitrous oxide (N2O) emission from fossil fuel combustion. The third in a series, it was held at the IFP in Rueil-Malmaison, France, on June 1-2, 1988. Increas...

  5. Travaux Neuchatelois de Linguistique (TRANEL) (Neuchatel Working Papers in Linguistics), Volume 14.

    ERIC Educational Resources Information Center

    Py, Bernard, Ed.; Rubattel, Christian, Ed.

    1989-01-01

    Three papers in linguistics, all in French, are presented. "La delocutivite lexicale en francais standard: esquisse d'un modele derivationnel" ("Lexical Delocutivity in Standard French: Sketch of a Derivational Model"), by Marc Bonhomme, examines the process by which certain expressions become neologisms. "La terminologie…

  6. Computer Experiments in Transformational Grammar; French I. Department of Computer and Communication Sciences Natural Language Studies No. 3.

    ERIC Educational Resources Information Center

    Morin, Yves Ch.

    Described in this paper is the implementation of Querido's French grammar ("Grammaire I, Description transformationelle d'un sous-ensemble du Francais," 1969) on the computer system for transformational grammar at the University of Michigan (Friedman 1969). The purpose was to demonstrate the ease of transcribing a relative formal grammar into the…

  7. ENGLISH AS A SECOND LANGUAGE FOR FRENCH-SPEAKING STUDENTS IN SECONDARY SCHOOLS.

    ERIC Educational Resources Information Center

    Ontario Curriculum Inst., Toronto.

    THIS REPORT WAS SUBMITTED IN JULY 1965 BY THE FRANCAIS SUB-COMMITTEE AND THE MODERN LANGUAGE COMMITTEE TO THE ONTARIO CURRICULUM INSTITUTE. THE SUBJECT WAS A SURVEY UNDERTAKEN IN 1964 TO STUDY THE TEACHING OF ENGLISH IN CANADIAN SECONDARY SCHOOLS ATTENDED BY FRENCH-SPEAKING STUDENTS. THE FUNDAMENTAL ISSUE INVOLVED IN THE SECONDARY EDUCATION OF…

  8. Grade 12 Diploma Examination. Examen en vue du diplome douzieme annee. Complete Set, January 1990.

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton.

    The Alberta (Canada) Department of Education issues "Grade 12 Diploma Examinations" for various disciplines every six months (dated January and June of each year). Except for the English and Francais examinations (which are issued only in their own language), the examinations are issued in an English edition and a French edition. The…

  9. FDM Video Classe: Modes d'emploi pour la classe (FDM Video Class: Classroom Uses).

    ERIC Educational Resources Information Center

    Beacco, Marcella Di Giura

    1996-01-01

    Content and design of the videotape series FDM Video Classe, produced by the journal "Le francais dans le monde," are described and classroom uses suggested. The materials are from authentic television programs, selected to illustrate aspects of French culture. It is suggested that the teacher also provide students with supporting…

  10. Television en classe!: L'experience "FDM video plus" (Television in Class!; The FDM Video Plus Experiment).

    ERIC Educational Resources Information Center

    di Giura, Marcella Beacco

    1994-01-01

    The problems and value of television as instructional material for the second-language classroom are discussed, and a new videocassette series produced by the journal "Francais dans le Monde" is described. Criteria for topic and segment selection are outlined, and suggestions are made for classroom use. (MSE)

  11. The Training of Modern Language Teachers in Various Countries. Collection d'"Etudes linguistiques," No. 20. Selected papers from the Association Internationale pour la Recherche et la Diffusion des Methodes Audio-Visuelles et Structuro-Globales Seminar (5th, August 27-September 1, 1973).

    ERIC Educational Resources Information Center

    Nivette, Jos, Ed.

    Selected papers that address theoretical and practical training of the modern language teacher and language teaching experiments in various countries are presented. Some of the articles included are the following: "Les problemes de la formation linguistique et pedagogique des professeurs de francais en Afrique Subsaharienne" (The…

  12. US Military, Commercial, and International Cooperation for Improved Space Situational Awareness

    DTIC Science & Technology

    2010-02-17

    and managing it, potential commercial and international members will see a less expensive yet credible method to obtain SSA benefits. Membership...data fulfills user expectations.  Establish an effective and efficient method for tasking framework sensors. 19 Functions The SSA framework...Laurence. “Space Situational Awareness and International Policy.” Working paper. Institut Francais Des Relations Internationales, October 2007

  13. Data Exchanges, XML, and Why the Exchange Problem Is Still Unsolved

    DTIC Science & Technology

    2005-09-27

    Intergovernmental Oceanographic Commission 2 BODC - British Oceanographic Data Centre 3 IFREMER - Institut Francais pour le Recherche et...effort resulted in the identification of 20 Bricks. The Bricks cover aspects of oceanographic data types such as analysis methods , calibration...ideas and methods discussed during the SGXML meetings, applying these ideas to the Tokyo Bay Environmental Information Center Project. An XML

  14. Combat Vehicle Test Beds: A Study of the Use of Test Beds in the Development of Combat Vehicles

    DTIC Science & Technology

    1983-05-01

    necessary to take advantage of test beds. In fact, test beds provide the only method of demonstrating new concepts clearly, and of allowing them to be...34, ARMOR, Vol, XCI, No.2, March-April, 1982. 11. Touzin, P., "Les Vehicules Blindes Francais 1945-1977", Editions EPA, 1978. 12. Lemboke, H.R., "A Tank of

  15. An Application of Didactic Criteria to Courseware Evaluation.

    ERIC Educational Resources Information Center

    Decoo, Wilfried

    1984-01-01

    Combines a software review with a suggestion for a format that will allow a fair comparison between similar software packages and will also be more complete, accurate, and meaningful to the potential user of the software. The software package "Le Francais Par Ordinateur" is reviewed by this method. (SED)

  16. Paradoxes in French-Language Instruction: Recent Social and Historical Research on Literacy in France

    ERIC Educational Resources Information Center

    Rockwell, Elsie; Galvao, Ana Maria

    2012-01-01

    This essay on three recent books by outstanding scholars--"La raison scolaire" by Bernard Lahire, "Histoire de l'enseignement du francais du XVII[superscript e] au XX[superscript e] siecle" by Andre Chervel, and "L'ecole et la lecture obligatoire" by Anne-Marie Chartier--offers the opportunity to acquaint readers with…

  17. Multilingual Thesauri for the Modern World - No Ideal Solution?

    ERIC Educational Resources Information Center

    Jorna, Kerstin; Davies, Sylvie

    2001-01-01

    Discusses thesauri as tools for multilingual information retrieval and cross-cultural communication. Considers the need for multilingual thesauri and the importance of explicit conceptual structures, and introduces a pilot thesaurus, InfoDEFT (Information Deutsch-English-Francais Thesaurus), as a possible model for new online thesauri which are…

  18. Proceedings: Pacific Northwest Council on Foreign Languages. Volume XXX, Part 2.

    ERIC Educational Resources Information Center

    Mazur, Gertrud S., Ed.

    The following papers of relevance to second language instruction are compiled here: (1) "Bilingual Math in a Monolingual Classroom: A Field Study," by Elizabeth M. Baricevic; (2) "Ideologie et pedagogie: reflexions sur le manuel de francais au programme de '3e annee secondaire' en Algerie," by Jeanne Adam; (3) "Pedagogic…

  19. Melanges, No. 23.

    ERIC Educational Resources Information Center

    Melanges, 1997

    1997-01-01

    Articles on second language teaching and learning include: "Ethnographie comparee de la salle de classe en France et en grande-Bretagne" (Comparative Ethnography of the Classroom Environment in France and Great Britain) (F. Carton); "Pour une approche micro et macro du francais parle dans la formation des enseignants de FLE"…

  20. ECMWF and ERS-1 Surface Winds Over the Arabian Sea During July 1995

    NASA Technical Reports Server (NTRS)

    Halpern, D.; Freilich, M. H.; Weller, R. A.

    1998-01-01

    The European Center for Medium-Range Weather Forecasts (ECMWF) and Institut Francais Pour la Recherche et 1'Exploitation de la Mer (IFREMER) European Remote-Sensing Satellite (ERS-1), named IFR2, surface wind velocity data products are compared during July 1995 over the Arabian Sea.

  1. The French Language in the Americas.

    ERIC Educational Resources Information Center

    Valdman, Albert, Ed.

    The annual bulletin of the French 8 section of the Annual Meeting of the Modern Language Association of America is presented with the texts of papers read at both the 1969 and 1970 sessions. The 1970 papers, in French, include Jean Louis Darbelnet's "Etude Sociolinguistique des contacts entre 1'Anglais et le Francais au Canada et en…

  2. Design and implementation of a packet switched routing chip

    NASA Astrophysics Data System (ADS)

    Joerg, Christopher F.

    1990-12-01

    Monsoon is a parallel processing dataflow computer that will require a high bandwidth interconnection network. A packet switched routing chip (PaRC) is described that will be used as the basis of this network. PaRC is a 4 by 4 routing switch which has been designed and fabricated as a CMOS gate array. PaRC will receive packets via one of its four input ports, store the packet in an on-chip buffer, and eventually transmit the packet via one of its four output ports. PaRC operates at 50 MHz, and each port has a bandwidth of 800 Mbits per second. Each input port operates asynchronously and has enough buffering to store four packets. The buffering and scheduling algorithms used in PaRC were designed to provide high utilization of the available bandwidth, while providing low latency for non-blocked packets. In addition, PaRC provides a mechanism whereby a processor can quickly receive acknowledgment when a message it sent has been received. Although the design of PaRC has been driven by the needs of Monsoon, PaRC has been designed to be suitable for a wide variety of communication networks.

  3. DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones.

    PubMed

    Bébéar, C M; Renaudin, H; Charron, A; Clerc, M; Pereyre, S; Bébéar, C

    2003-10-01

    Twelve clinical isolates of Ureaplasma spp. and one isolate of Mycoplasma hominis were examined for resistance to fluoroquinolones. Previously described mutations at positions 83 and 95 in GyrA (Escherichia coli numbering) and positions 80 and 87 in ParC were found. Unusual alterations were described at positions ParC 123 and 134.

  4. Speaking Personally--With John Seely Brown

    ERIC Educational Resources Information Center

    American Journal of Distance Education, 2008

    2008-01-01

    This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

  5. Speaking Personally--With John Seely Brown

    ERIC Educational Resources Information Center

    American Journal of Distance Education, 2008

    2008-01-01

    This article presents an interview with John Seely Brown, a visiting scholar at the University of Southern California and a former chief scientist of Xerox Corporation and director of its Palo Alto Research Center (PARC)--a position he held for nearly two decades. While head of PARC, Brown expanded the role of corporate research to include such…

  6. Les mammiferes aquatiques: lexique anglais-francais des mammiferes marins actuels ou recemment disparus, y compris les especes d'eau douce des groupes surtout marins (Aquatic Mammals: English-French Glossary of Livinq or Recently Extinct Marine Mammals, Including the Fresh Water Species of Prevalently Marine Groups).

    ERIC Educational Resources Information Center

    Nekrassoff, Vladimir N.

    1980-01-01

    Introduces a new glossary of aquatic mammals representing recent taxonomic revisions. Describes its design, which consists of the glossary proper, listing the scientific name of each entry followed by its English and French equivalents, and of two indexes, listing other common names for the same entries referred back to the scientific term. (MES)

  7. Les mammiferes aquatiques: lexique anglais-francais des mammiferes marins actuels ou recemment disparus, y compris les especes d'eau douce des groupes surtout marins (Aquatic Mammals: English-French Glossary of Livinq or Recently Extinct Marine Mammals, Including the Fresh Water Species of Prevalently Marine Groups).

    ERIC Educational Resources Information Center

    Nekrassoff, Vladimir N.

    1980-01-01

    Introduces a new glossary of aquatic mammals representing recent taxonomic revisions. Describes its design, which consists of the glossary proper, listing the scientific name of each entry followed by its English and French equivalents, and of two indexes, listing other common names for the same entries referred back to the scientific term. (MES)

  8. Tu peux compter sur moi: Guide a l'intention du parent pour l'accompagnement de l'enfant dans son education en francais langue premiere (You Can Count on Me: Guide for Parents for Accompanying Their Child in French as a First Language Education).

    ERIC Educational Resources Information Center

    Federation des parents francophones de l'Alberta, Edmonton (Canada).

    This guidebook is intended for parents of French-speaking students in Alberta. It describes French-as-a-first-language education in Alberta and provides information to help parents, in collaboration with school personnel and the wider francophone community in Alberta, to preserve and develop their children's identity as speakers of French and as…

  9. Le role des capacites metalinguistiques et de la competence langagiere orale dans l'apprentissage de la lecture en francais langage premiere et seconde (The Role of Metalinguistic Capacities and Oral Language Skills in Learning Reading in French as a First and Second Language).

    ERIC Educational Resources Information Center

    Armand, Francoise

    2000-01-01

    Analyzes the role played by oral language skills and by metalinguistic capacities in the reading performance of young beginner readers in French as a second language who are in a situation of successive bilingualism and observing whether differences exist between them and their francophone peers of the same age. (Author/VWL)

  10. Francais langue etrangere en milieu homoglotte et alloglotte: quels enseignements pour quelles pratiques effectives, quelles pratiques effectives apres quels enseignements? (French as a Foreign Language in Homoglot and Alloglot Environments: What Lessons To Teach for Which Effective Practices, Which Effective Practices Follow What Lessons?)

    ERIC Educational Resources Information Center

    Gauthier, Claude, Ed.; Jeanneret, Therese, Ed.

    2000-01-01

    The articles in this volume are based on a survey of language learners carried out at five Swiss universities. The surveys (done through interviews and questionnaires) concern the ways that students encounter their second language (French) outside the classroom, and which of those practices are the most effective in improving their French. The…

  11. Francais langue seconde: trousse d'evaluation--tests modeles pour le niveau debutant 1, niveau debutant 2, niveau debutant 3 des ecoles elementaires (French as a Second Language: Evaluation Resource Package--Model Tests for Beginning Level 1, Beginning Level 2, Beginning Level 3 in Elementary Schools).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The French as a Second Language model tests for beginning levels 1, 2, and 3 were designed to evaluate students' language performance, as outlined in the program of studies for Alberta, Canada, in listening and reading comprehension and oral and written production, communication skills, culture, language and general language knowledge. The tests…

  12. Francais langue seconde: trousse d'evaluation--tests modeles pour les cours: French 31a (Avance 7); French 31b (Avance 8); French 31c (Avance 9) (French as a Second Language: Evaluation Resource Package--Model Tests for the Courses: French 31a (Advanced 7); French 31b (Advanced 8); French 31c (Advanced 9)).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The French as a Second Language model tests for advanced levels 7, 8, and 9 were designed to evaluate students' language performance, as outlined in the program of studies for Alberta, Canada, in listening and reading comprehension and oral and written production, communication skills, culture, language and general language knowledge. The tests…

  13. La Crise est arrivee: la croissance des programmes de francais langue seconde et ses repercussions sur la qualite et le nombre des enseignants (The Crisis Has Arrived: The Growth of French as a Second Language Programs and Repercussions for the Quality and Number of Teachers).

    ERIC Educational Resources Information Center

    Obadia, Andre A.

    1989-01-01

    A study of faculties of education in Canadian universities shows that the quality of French teacher training needs improvement and may run the risk of further deterioration. The tremendous student increase in French-as-a-Second-Language programs is already causing a gradual but serious shortage of French teachers. (Author/MSE)

  14. Faut - il enseigner l'accord du participe passe avec "avoir?" Wuelques observations sur l'accord du participe passe en francais parle. (Do We Need to Teach Agreement of the Past Participle with "avoir?" Some Observations on the Agreement of the Past Participle in Spoken French).

    ERIC Educational Resources Information Center

    Barrera-Vidal, Albert

    1979-01-01

    Pleads for proper consideration, in teaching French, of the continuing process of evolution of the language. Discusses, as an example of language change, the past participle construction in respect to distribution, morphology, and syntax. (IFS/WGA)

  15. Fiche Pratique: Concours TV 5--La television a l'ecole; Autre temps, autre temps; Cassette FDM frequence plus--l'invite; Science en francais (Practical Ideas: TV 5 Competition--Television in Schools; Once Again, Another Tense; The "FDM" Audiocassette Series--The Guest; Science in French).

    ERIC Educational Resources Information Center

    Cuncea, Nicolae; And Others

    1993-01-01

    The language classroom activities described include work with TV programs (interviews, cooking demonstrations, scenes without soundtrack); exercises with passe compose and passe simple verb tenses; descriptions of available French cassette programs; and use of texts on scientific subjects to build reading for meaning. (CNP)

  16. Francais langue seconde: trousse d'evaluation--tests modeles pour le niveau debutant 1, niveau debutant 2, niveau debutant 3 des ecoles elementaires (French as a Second Language: Evaluation Resource Package--Model Tests for Beginning Level 1, Beginning Level 2, Beginning Level 3 in Elementary Schools).

    ERIC Educational Resources Information Center

    Alberta Dept. of Education, Edmonton. Language Services Branch.

    The French as a Second Language model tests for beginning levels 1, 2, and 3 were designed to evaluate students' language performance, as outlined in the program of studies for Alberta, Canada, in listening and reading comprehension and oral and written production, communication skills, culture, language and general language knowledge. The tests…

  17. (Biotechnology for the conversion of lignocellulosics)

    SciTech Connect

    Woodward, J.

    1990-10-25

    This report summarizes the results of the traveler's participation in the International Energy Agency (IEA) Network planning meeting for Biotechnology for the Conversion of Lignocellulosics,'' held at the Institut Francais du Petrole (IFP), Rueil-Malmaison, France. It also summarizes the results of discussions held at Aston University, Birmingham, UK, with Dr. Martin Beevers with whom the traveler is attempting to initiate a collaborative research project that will be beneficial to ongoing research programs at Oak Ridge National Laboratory (ORNL). The itinerary for the trip is given in Appendix A; the names of the people contacted are listed in Appendix B. Also, pertinent information about the Institut Francais du Petrole is attached (Appendix C). 1 tab.

  18. Visual Problems in Night Operations (Problemes de Vision dans les Operations de Nuit)

    DTIC Science & Technology

    1992-05-01

    cellules C a C~ B C~ C ganglionnaires. Ce sont leurs axones qtii constituent lea fibres du nedf optique. Lea celiules ganglionnairea vehiculent lea...fields. FrenchTitle/ TITRE FRANCAIS Vision nocturne. EnglishTitle/ TITRE ANGLAIS Night vision. Type o’ Document, TYPE DE DOCUMENT Publication en serie...nocturne oes vehicules de combat pendant la guerre du Golfe (Hughes Aircraft Infra red thermal Imaging System night vision equipment Texas Instrument

  19. Design and Implementation of Practical Constraint Logic Programming Systems

    DTIC Science & Technology

    1992-08-24

    Pasero, and P. Roussel. Une systeme de com- munication homme-machine en Francais. Technical report, Groupe Intelligence Artificielle , Universite Aix...Marseille II, France, 1973. [28] Alain Colmerauer. PROLOG II reference manual and theoretical model. Techni- cal report, Groupe Intelligence ... Artificielle , Universit6 Aix - Marseille II, October 1982. [29] Alain Colmerauer. Equations and inequations on finite and infinite trees. In Pro- ceedings of the

  20. Building Partnership Capacity: Operation Harmattan and Beyond

    DTIC Science & Technology

    2012-10-01

    francaises-en-cote-d-ivoire. 30. “977 Français en provenance du Japon en route vers la France,” Reuters, 19 March 2011, http://www.lepoint.fr/fil-info...reuters/977-francais-en-provenance-du- japon -en-route -vers-la-france-19-03-2011-1308690_240.php. 31. “Les avions français interviennent en Libye,” Le