Impact Assessment and Environmental Evaluation of Various Ammonia Production Processes.

PubMed

Bicer, Yusuf; Dincer, Ibrahim; Vezina, Greg; Raso, Frank

2017-05-01

In the current study, conventional resources-based ammonia generation routes are comparatively studied through a comprehensive life cycle assessment. The selected ammonia generation options range from mostly used steam methane reforming to partial oxidation of heavy oil. The chosen ammonia synthesis process is the most common commercially available Haber-Bosch process. The essential energy input for the methods are used from various conventional resources such as coal, nuclear, natural gas and heavy oil. Using the life cycle assessment methodology, the environmental impacts of selected methods are identified and quantified from cradle to gate. The life cycle assessment outcomes of the conventional resources based ammonia production routes show that nuclear electrolysis-based ammonia generation method yields the lowest global warming and climate change impacts while the coal-based electrolysis options bring higher environmental problems. The calculated greenhouse gas emission from nuclear-based electrolysis is 0.48 kg CO 2 equivalent while it is 13.6 kg CO 2 per kg of ammonia for coal-based electrolysis method.

Low cycle fatigue properties of MAR-M-246 Hf in hydrogen. [a cast nickel-base alloy

NASA Technical Reports Server (NTRS)

Warren, J. R.

1979-01-01

The transverse, low cycle fatigue properties were determined for directionally solidified and single crystal samples of a cast nickel-base alloy proposed for use in space propulsion systems in pure or partial high pressure hydrogen environments at elevated temperatures. The test temperature was 760 C (1400F) and the pressure of the gaseous hydrogen was 34.5 MPa (5000 psig). Low cycle fatique life was established by strain controlled testing using smooth specimens and a servohydraulic closed-loop test machine modified with a high pressure environmental chamber. Results and conclusions are discussed.

NUMBER AND TYPE OF OPERATING CYCLES FOR THE FFTF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, D. C.

1969-05-15

The choice of materials and other vessel design decisions necessary to provide the desired life expectancy for the FTR vessel are partially dependent upon estimates of the number and type of reactor shutdowns and startups which may be anticipated. Current estimates of these so-called "cycles" are given, including scram frequency, experimental outage frequency, standard shutdowns and startups, and rapid controlled shutdowns. Also discussed are abnormal heatup or cooldown, and tentative goals for temperature controls. MTR, ETR, and typical PRTR operating histories are tabulated.

Checks and balances? DNA replication and the cell cycle in Plasmodium.

PubMed

Matthews, Holly; Duffy, Craig W; Merrick, Catherine J

2018-03-27

It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic screens have partially filled the void in the antimalarial drug market, but as compound libraries eventually become exhausted, new medicines will only come from directed drug development based on a better understanding of fundamental parasite biology. This review focusses on the unusual cell cycles of Plasmodium, which may present a rich source of novel drug targets as well as a topic of fundamental biological interest. Plasmodium does not grow by conventional binary fission, but rather by several syncytial modes of replication including schizogony and sporogony. Here, we collate what is known about the various cell cycle events and their regulators throughout the Plasmodium life-cycle, highlighting the differences between Plasmodium, model organisms and other apicomplexan parasites and identifying areas where further study is required. The possibility of DNA replication and the cell cycle as a drug target is also explored. Finally the use of existing tools, emerging technologies, their limitations and future directions to elucidate the peculiarities of the Plasmodium cell cycle are discussed.

The Role of Skepticism in Preparing Teachers for the Use of Technology.

ERIC Educational Resources Information Center

Albaugh, Patti R.

The complexity of technology training for teachers can be partially explained in terms of three phenomena: the historical resistance of teachers to use media, the nature of teaching itself, and the life cycle of technological innovations. Factors that influence teachers' use of technology include: accessibility of hardware and software,…

Energy storage devices for future hybrid electric vehicles

NASA Astrophysics Data System (ADS)

Karden, Eckhard; Ploumen, Servé; Fricke, Birger; Miller, Ted; Snyder, Kent

Powertrain hybridization as well as electrical energy management are imposing new requirements on electrical storage systems in vehicles. This paper characterizes the associated vehicle attributes and, in particular, the various levels of hybrids. New requirements for the electrical storage system are derived, including: shallow-cycle life, high dynamic charge acceptance particularly for regenerative braking and robust service life in sustained partial-state-of-charge usage. Lead/acid, either with liquid or absorptive glass-fibre mat electrolyte, is expected to remain the predominant battery technology for 14 V systems, including micro-hybrids, and with a cost-effective battery monitoring system for demanding applications. Advanced AGM batteries may be considered for mild or even medium hybrids once they have proven robustness under real-world conditions, particularly with respect to cycle life at partial-states-of-charge and dynamic charge acceptance. For the foreseeable future, NiMH and Li-ion are the dominating current and potential battery technologies for higher-functionality HEVs. Li-ion, currently at development and demonstration stages, offers attractive opportunities for improvements in performance and cost. Supercapacitors may be considered for pulse power applications. Aside from cell technologies, attention to the issue of system integration of the battery into the powertrain and vehicle is growing. Opportunities and challenges for potential "battery pack" system suppliers are discussed.

Studies on hydride-forming alloys as the active material of a metal hydride electrode for a nickel metal hydride cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, H.S.; Zelter, G.R.; Allison, D.U.

1997-12-01

Multi-component AB{sub 5} hydrides are attractive replacements for the cadmium electrode in nickel-cadmium batteries. The archetype compound of the AB{sub 5} alloy class is LaNi{sub 5}, but in a typical battery electrode mischmetal is substituted for La and Ni is substituted in part by variety of metals. This paper deals with the effect on cycle life upon the partial substitution of various lanthanides for La and Sn, In, Al, Co, and Mn for Ni. The presence of Ce was shown to enhance cycle life as did Sn in some cases. An electrode of La{sub 0.67}Ce{sub 0.33}B{sub 5} alloy gave overmore » 3,500 cycles (to specific capacity of 200 mAh/g), indicating that it is a very attractive alloy for a practical Ni/MH{sub x} cell.« less

Synthesis and degradation of nitrate reductase during the cell cycle of Chlorella sorokiniana

NASA Technical Reports Server (NTRS)

Velasco, P. J.; Tischner, R.; Huffaker, R. C.; Whitaker, J. R.

1989-01-01

Studies on the diurnal variations of nitrate reductase (NR) activity during the life cycle of synchronized Chlorella sorokiniana cells grown with a 7:5 light-dark cycle showed that the NADH:NR activity, as well as the NR partial activities NADH:cytochrome c reductase and reduced methyl viologen:NR, closely paralleled the appearance and disappearance of NR protein as shown by sodium dodecyl sulfate gel electrophoresis and immunoblots. Results of pulse-labeling experiments with [35S]methionine further confirmed that diurnal variations of the enzyme activities can be entirely accounted for by the concomitant synthesis and degradation of the NR protein.

From individual to population level effects of toxicants in the tubicifid Branchiura sowerbyi using threshold effect models in a Bayesian framework.

PubMed

Ducrot, Virginie; Billoir, Elise; Péry, Alexandre R R; Garric, Jeanne; Charles, Sandrine

2010-05-01

Effects of zinc were studied in the freshwater worm Branchiura sowerbyi using partial and full life-cycle tests. Only newborn and juveniles were sensitive to zinc, displaying effects on survival, growth, and age at first brood at environmentally relevant concentrations. Threshold effect models were proposed to assess toxic effects on individuals. They were fitted to life-cycle test data using Bayesian inference and adequately described life-history trait data in exposed organisms. The daily asymptotic growth rate of theoretical populations was then simulated with a matrix population model, based upon individual-level outputs. Population-level outputs were in accordance with existing literature for controls. Working in a Bayesian framework allowed incorporating parameter uncertainty in the simulation of the population-level response to zinc exposure, thus increasing the relevance of test results in the context of ecological risk assessment.

An evaluation of fish early life stage tests for predicting reproductive and longer-term toxicity from plant protection product active substances.

PubMed

Wheeler, James R; Maynard, Samuel K; Crane, Mark

2014-08-01

The chronic toxicity of chemicals to fish is routinely assessed by using fish early life stage (ELS) test results. Fish full life cycle (FLC) tests are generally required only when toxicity, bioaccumulation, and persistence triggers are met or when there is a suspicion of potential endocrine-disrupting properties. This regulatory approach is based on a relationship between the results of fish ELS and FLC studies first established more than 35 yrs ago. Recently, this relationship has been challenged by some regulatory authorities, and it has been recommended that more substances should undergo FLC testing. In addition, a project proposal has been submitted to the Organisation for Economic Cooperation and Development (OECD) to develop a fish partial life cycle (PLC) test including a reproductive assessment. Both FLC and PLC tests are animal- and resource-intensive and technically challenging and should therefore be undertaken only if there is clear evidence that they are necessary for coming to a regulatory decision. The present study reports on an analysis of a database of paired fish ELS and FLC endpoints for plant protection product active substances from European Union draft assessment reports and the US Environmental Protection Agency Office of Pesticide Programs Pesticide Ecotoxicity Database. Analysis of this database shows a clear relationship between ELS and FLC responses, with similar median sensitivity across substances when no-observed-effect concentrations (NOECs) are compared. There was also no indication that classification of a substance as a mammalian reproductive toxicant leads to more sensitive effects in fish FLC tests than in ELS tests. Indeed, the response of the ELS tests was generally more sensitive than the most sensitive reproduction NOEC from a FLC test. This analysis indicates that current testing strategies and guidelines are fit for purpose and that there is no need for fish full or partial life cycle tests for most plant protection product active substances. © 2014 SETAC.

Advanced valve-regulated lead-acid batteries for hybrid vehicle applications

NASA Astrophysics Data System (ADS)

Soria, M. L.; Trinidad, F.; Lacadena, J. M.; Sánchez, A.; Valenciano, J.

Future vehicle applications require the development of reliable and long life batteries operating under high-rate partial-state-of-charge (HRPSoC) working conditions. Work presented in this paper deals with the study of different design parameters, manufacturing process and charging conditions of spiral wound valve-regulated lead-acid (VRLA) batteries, in order to improve their reliability and cycle life for hybrid vehicle applications. Test results show that both electrolyte saturation and charge conditions have a strong effect on cycle life at HRPSoC performance, presumably because water loss finally accelerates battery failure, which is linked to irreversible sulphation in the upper part of the negative electrodes. By adding expanded graphite to the negative active mass formulation, increasing the electrolyte saturation degree (>95%) and controlling overcharge during regenerative braking periods (voltage limitation and occasional boosting) it is possible to achieve up to 220,000 cycles at 2.5% DOD, equivalent to 5500 capacity throughput. These results could make lead acid batteries a strong competitor for HEV applications versus other advanced systems such as Ni-MH or Li-ion batteries.

[New infectious diseases in Finland--caused by climate change?].

PubMed

Vapalahti, Olli; Ruuhela, Reija; Henttonen, Heikki

2012-01-01

Although the appearance and spreading of most new infectious diseases are likely to be due to globalization or socio-economic changes, the occurrence of tick-, insect- and rodent-borne infections is at least partially dependent on climate variability and change. Climate influences the distribution and life cycle of vectors of arthropod-borne viruses as well as viral evolution and efficacy of transmission. The natural circulation of many pathogens and the development of epidemics are dependent on complex ecological factors, such as biodiversity and predator-prey cycles that in turn are indirectly linked to climate.

Supercritical CO2 Power Cycles: Design Considerations for Concentrating Solar Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neises, Ty; Turchi, Craig

2014-09-01

A comparison of three supercritical CO2 Brayton cycles: the simple cycle, recompression cycle and partial-cooling cycle indicates the partial-cooling cycle is favored for use in concentrating solar power (CSP) systems. Although it displays slightly lower cycle efficiency versus the recompression cycle, the partial-cooling cycle is estimated to have lower total recuperator size, as well as a lower maximum s-CO2 temperature in the high-temperature recuperator. Both of these effects reduce recuperator cost. Furthermore, the partial-cooling cycle provides a larger temperature differential across the turbine, which translates into a smaller, more cost-effective thermal energy storage system. The temperature drop across the turbinemore » (and by extension, across a thermal storage system) for the partial-cooling cycle is estimated to be 23% to 35% larger compared to the recompression cycle of equal recuperator conductance between 5 and 15 MW/K. This reduces the size and cost of the thermal storage system. Simulations by NREL and Abengoa Solar indicate the partial-cooling cycle results in a lower LCOE compared with the recompression cycle, despite the former's slightly lower cycle efficiency. Advantages of the recompression cycle include higher thermal efficiency and potential for a smaller precooler. The overall impact favors the use of a partial-cooling cycle for CSP compared to the more commonly analyzed recompression cycle.« less

An Exploration of the Relationship between Improvements in Energy Efficiency and Life-Cycle Energy and Carbon Emissions using the BIRDS Low-Energy Residential Database.

PubMed

Kneifel, Joshua; O'Rear, Eric; Webb, David; O'Fallon, Cheyney

2018-02-01

To conduct a more complete analysis of low-energy and net-zero energy buildings that considers both the operating and embodied energy/emissions, members of the building community look to life-cycle assessment (LCA) methods. This paper examines differences in the relative impacts of cost-optimal energy efficiency measure combinations depicting residential buildings up to and beyond net-zero energy consumption on operating and embodied flows using data from the Building Industry Reporting and Design for Sustainability (BIRDS) Low-Energy Residential Database. Results indicate that net-zero performance leads to a large increase in embodied flows (over 40%) that offsets some of the reductions in operational flows, but overall life-cycle flows are still reduced by over 60% relative to the state energy code. Overall, building designs beyond net-zero performance can partially offset embodied flows with negative operational flows by replacing traditional electricity generation with solar production, but would require an additional 8.34 kW (18.54 kW in total) of due south facing solar PV to reach net-zero total life-cycle flows. Such a system would meet over 239% of operational consumption of the most energy efficient design considered in this study and over 116% of a state code-compliant building design in its initial year of operation.

"Birds of passage" or "career" women? Thoughts on the life cycle of the eighteenth-century European servant.

PubMed

Simonton, Deborah

2011-01-01

Frequently eighteenth-century service is described as a life-cycle stage used to build up the financial wherewithal to set up house. As such it was central to the way youth or girlhood was traversed, and studies of adolescent years rightly emphasise the importance of service. However, this narrative, while largely accurate, is also problematic. What happened when service did not end with marriage, or when a woman remained single well into adulthood? In practice, servants were found among both the married and single, and among the young and the old. Concentrating on the eighteenth century, and incorporating material from Nordic Europe, this article teases out some of the nuances in the context and experience of service that partially disrupt the established narrative.

Fruiting Body Formation in Volvariella volvacea Can Occur Independently of Its MAT-A-Controlled Bipolar Mating System, Enabling Homothallic and Heterothallic Life Cycles.

PubMed

Chen, Bingzhi; van Peer, Arend F; Yan, Junjie; Li, Xiao; Xie, Bin; Miao, Juan; Huang, Qianhui; Zhang, Lei; Wang, Wei; Fu, Junsheng; Zhang, Xiang; Zhang, Xiaoyin; Hu, Fengli; Kong, Qingfang; Sun, Xianyun; Zou, Feng; Zhang, Hanxing; Li, Shaojie; Xie, Baogui

2016-07-07

Volvariella volvacea is an important crop in Southeast Asia, but erratic fruiting presents a serious challenge for its production and breeding. Efforts to explain inconsistent fruiting have been complicated by the multinucleate nature, typical lack of clamp connections, and an incompletely identified sexual reproductive system. In this study, we addressed the life cycle of V. volvacea using whole genome sequencing, cloning of MAT loci, karyotyping of spores, and fruiting assays. Microscopy analysis of spores had previously indicated the possible coexistence of heterothallic and homothallic life cycles. Our analysis of the MAT loci showed that only MAT-A, and not MAT-B, controlled heterokaryotization. Thus, the heterothallic life cycle was bipolar. Karyotyping of single spore isolates (SSIs) using molecular markers supported the existence of heterokaryotic spores. However, most SSIs were clearly not heterokaryotic, yet contained structural variation (SV) markers relating to both alleles of both parents. Heterokaryons from crossed, self-sterile homokaryons could produce fruiting bodies, agreeing with bipolar heterothallism. Meanwhile, some SSIs with two different MAT-A loci also produced fruiting bodies, which supported secondary homothallism. Next, SSIs that clearly contained only one MAT-A locus (homothallism) were also able to fruit, demonstrating that self-fertile SSIs were not, per definition, secondary homothallic, and that a third life cycle or genetic mechanism must exist. Finally, recombination between SV markers was normal, yet 10 out of 24 SV markers showed 1:2 or 1:3 distributions in the spores, and large numbers of SSIs contained doubled SV markers. This indicated selfish genes, and possibly partial aneuploidy. Copyright © 2016 Chen et al.

Limit Cycles Can Reduce the Width of the Habitable Zone

NASA Astrophysics Data System (ADS)

Haqq-Misra, Jacob; Kopparapu, Ravi Kumar; Batalha, Natasha E.; Harman, Chester E.; Kasting, James F.

2016-08-01

The liquid water habitable zone (HZ) describes the orbital distance at which a terrestrial planet can maintain above-freezing conditions through regulation by the carbonate-silicate cycle. Recent calculations have suggested that planets in the outer regions of the HZ cannot maintain stable, warm climates, but rather should oscillate between long, globally glaciated states and shorter periods of climatic warmth. Such conditions, similar to “Snowball Earth” episodes experienced on Earth, would be inimical to the development of complex land life, including intelligent life. Here, we build on previous studies with an updated energy balance climate model to calculate this “limit cycle” region of the HZ where such cycling would occur. We argue that an abiotic Earth would have a greater CO2 partial pressure than today because plants and other biota help to enhance the storage of CO2 in soil. When we tune our abiotic model accordingly, we find that limit cycles can occur but that previous calculations have overestimated their importance. For G stars like the Sun, limit cycles occur only for planets with CO2 outgassing rates less than that on modern Earth. For K- and M-star planets, limit cycles should not occur; however, M-star planets may be inhospitable to life for other reasons. Planets orbiting late G-type and early K-type stars retain the greatest potential for maintaining warm, stable conditions. Our results suggest that host star type, planetary volcanic activity, and seafloor weathering are all important factors in determining whether planets will be prone to limit cycling.

Career management: understanding the process.

PubMed

Mackowiak, J; Eckel, F M

1985-02-01

This article is the first of a three-part series on career management for hospital pharmacists. Work attitudes, life cycles, needs, and career trends are discussed. Three basic work attitudes exist. Some see work as punishment. Others believe work in itself is good, i.e., they have a strong work ethic. Some view work as a means to satisfy, at least partially, a range of needs. Attitudinal transition points are likely to occur at specific times in the adult life cycle. The stages of the life cycle can be labeled as leaving, reaching out, questioning, midlife crisis, settling down, and mellowing. A progression through each of these stages is required for normal adult psychological development. Every individual exhibits a blend of needs that changes throughout life. Jobs can fulfill existence, relatedness, and growth needs. Relatedness needs include the need for love, affiliation, social esteem, and power, and growth needs include the need for self-esteem, competence, achievement, and autonomy. Three important career trends are the changing opportunities for advancement, women in careers, and dual-career couples. The number of women pharmacists is increasing as is the number of two-career couples. Tips for managing two-career relationships are presented. Pharmacists can manage their careers more effectively by understanding their needs, identifying their basic attitude toward work, and being aware of the trends occurring in pharmacy.

Lead-acid batteries for micro- and mild-hybrid applications

NASA Astrophysics Data System (ADS)

Valenciano, J.; Fernández, M.; Trinidad, F.; Sanz, L.

Car manufactures have announced the launch in coming months of vehicles with reduced emissions due to the introduction of new functions like stop-start and regenerative braking. Initial performance request of automotive lead-acid batteries are becoming more and more demanding and, in addition to this, cycle life with new accelerated ageing profiles are being proposed in order to determine the influence of the new functions on the expected battery life. This paper will show how different lead-acid battery technologies comply with these new demands, from an improved version of the conventional flooded SLI battery to the high performance of spiral wound valve-regulated lead-acid (VRLA) battery. Different approaches have been studied for improving conventional flooded batteries, i.e., either by the addition of new additives for reducing electrolyte stratification or by optimisation of the battery design to extend cycling life in partial state of charge conditions. With respect to VRLA technology, two different battery designs have been compared. Spiral wound design combines excellent power capability and cycle life under different depth of discharge (DoD) cycling conditions, but flat plate design outperform the latter in energy density due to better utilization of the space available in a prismatic enclosure. This latter design is more adequate for high end class vehicles with high electrical energy demand, whereas spiral wound is better suited for high power/long life demand of commercial vehicle. High temperature behaviour (75 °C) is rather poor for both designs due to water loss, and then VRLA batteries should preferably be located out of the engine compartment.

Effects of complex life cycles on genetic diversity: cyclical parthenogenesis.

PubMed

Rouger, R; Reichel, K; Malrieu, F; Masson, J P; Stoeckel, S

2016-11-01

Neutral patterns of population genetic diversity in species with complex life cycles are difficult to anticipate. Cyclical parthenogenesis (CP), in which organisms undergo several rounds of clonal reproduction followed by a sexual event, is one such life cycle. Many species, including crop pests (aphids), human parasites (trematodes) or models used in evolutionary science (Daphnia), are cyclical parthenogens. It is therefore crucial to understand the impact of such a life cycle on neutral genetic diversity. In this paper, we describe distributions of genetic diversity under conditions of CP with various clonal phase lengths. Using a Markov chain model of CP for a single locus and individual-based simulations for two loci, our analysis first demonstrates that strong departures from full sexuality are observed after only a few generations of clonality. The convergence towards predictions made under conditions of full clonality during the clonal phase depends on the balance between mutations and genetic drift. Second, the sexual event of CP usually resets the genetic diversity at a single locus towards predictions made under full sexuality. However, this single recombination event is insufficient to reshuffle gametic phases towards full-sexuality predictions. Finally, for similar levels of clonality, CP and acyclic partial clonality (wherein a fixed proportion of individuals are clonally produced within each generation) differentially affect the distribution of genetic diversity. Overall, this work provides solid predictions of neutral genetic diversity that may serve as a null model in detecting the action of common evolutionary or demographic processes in cyclical parthenogens (for example, selection or bottlenecks).

Comparative life cycle assessment and life cycle costing of four disposal scenarios for used polyethylene terephthalate bottles in Mauritius.

PubMed

Foolmaun, Rajendra Kumar; Ramjeeawon, Toolseeram

2012-09-01

The annual rise in population growth coupled with the flourishing tourism industry in Mauritius has lead to a considerable increase in the amount of solid waste generated. In parallel, the disposal of non-biodegradable wastes, especially plastic packaging and plastic bottles, has also shown a steady rise. Improper disposal of used polyethylene terephthalate (PET) bottles constitutes an eyesore to the environmental landscape and is a threat to the flourishing tourism industry. It is of utmost importance, therefore, to determine a suitable disposal method for used PET bottles which is not only environmentally efficient but is also cost effective. This study investigated the environmental impacts and the cost effectiveness of four selected disposal alternatives for used PET bottles in Mauritius. The four disposal routes investigated were: 100% landfilling; 75% incineration with energy recovery and 25% landfilling; 40% flake production (partial recycling) and 60% landfilling; and 75% flake production and 25% landfilling. Environmental impacts of the disposal alternatives were determined using ISO standardized life cycle assessment (LCA) and with the support of SimaPro 7.1 software. Cost effectiveness was determined using life cycle costing (LCC). Collected data were entered into a constructed Excel-based model to calculate the different cost categories, Net present values, damage costs and payback periods. LCA and LCC results indicated that 75% flake production and 25% landfilling was the most environmentally efficient and cost-effective disposal route for used PET bottles in Mauritius.

Rock Smelting of Copper Ores with Waste Heat Recovery

NASA Astrophysics Data System (ADS)

Norgate, Terry; Jahanshahi, Sharif; Haque, Nawshad

It is generally recognised that the grades of metallic ores are falling globally. This trend can be expected to increase the life cycle-based energy requirement for primary metal production due to the additional amount of material that must be handled and treated in the mining and mineral processing stages of the metal production life cycle. Rock (or whole ore) smelting has been suggested as a possible alternative processing route for low grade ores with a potentially lower energy intensity and environmental impact than traditional processing routes. In this processing route, the beneficiation stage is eliminated along with its associated energy consumption and greenhouse gas emissions, but this is partially offset by the need for more solid material to be handled and heated up to smelting temperatures. A life cycle assessment study was carried out to assess the potential energy and greenhouse gas benefits of a conceptual flowsheet of the rock smelting process, using copper ore as an example. Recovery and utilisation of waste heat in the slag (via dry slag granulation) and offgas streams from the smelting step was also included in the study, with the waste heat being utilised either for thermal applications or electricity generation.

Cosolvent electrolytes for electrochemical devices

DOEpatents

Wessells, Colin Deane; Firouzi, Ali; Motallebi, Shahrokh; Strohband, Sven

2018-01-23

A method for stabilizing electrodes against dissolution and/or hydrolysis including use of cosolvents in liquid electrolyte batteries for three purposes: the extension of the calendar and cycle life time of electrodes that are partially soluble in liquid electrolytes, the purpose of limiting the rate of electrolysis of water into hydrogen and oxygen as a side reaction during battery operation, and for the purpose of cost reduction.

Cosolvent electrolytes for electrochemical devices

DOEpatents

Wessells, Colin Deane; Firouzi, Ali; Motallebi, Shahrokh; Strohband, Sven

2018-02-13

A system and method for stabilizing electrodes against dissolution and/or hydrolysis including use of cosolvents in liquid electrolyte batteries for three purposes: the extension of the calendar and cycle life time of electrodes that are partially soluble in liquid electrolytes, the purpose of limiting the rate of electrolysis of water into hydrogen and oxygen as a side reaction during battery operation, and for the purpose of cost reduction.

Cosolvent electrolytes for electrochemical devices

DOEpatents

Wessells, Colin Deane; Firouzi, Ali; Motallebi, Shahrokh; Strohband, Sven

2018-05-15

A system and method for stabilizing electrodes against dissolution and/or hydrolysis including use of cosolvents in liquid electrolyte batteries for three purposes: the extension of the calendar and cycle life time of electrodes that are partially soluble in liquid electrolytes, the purpose of limiting the rate of electrolysis of water into hydrogen and oxygen as a side reaction during battery operation, and for the purpose of cost reduction.

The fuel market effects of biofuel policies and implications for regulations based on lifecycle emissions

NASA Astrophysics Data System (ADS)

Rajagopal, Deepak

2013-06-01

The absence of a globally-consistent and binding commitment to reducing greenhouse emissions provides a rationale for partial policies, such as renewable energy mandates, product emission standards, etc to target lifecycle emissions of the regulated products or services. While appealing in principle, regulation of lifecycle emissions presents several practical challenges. Using biofuels as an illustrative example, we highlight some outstanding issues in the design and implementation of life cycle-based policies and discuss potential remedies. We review the literature on emissions due to price effects in fuel markets, which are akin to emissions due to indirect land use change, but are, unlike the latter, ignored under all current life cycle emissions-based regulations. We distinguish the current approaches to regulating indirect emissions into hard and soft approaches and discuss their implications.

The VRLA modular wound design for 42 V mild hybrid systems

NASA Astrophysics Data System (ADS)

Trinidad, F.; Gimeno, C.; Gutiérrez, J.; Ruiz, R.; Sainz, J.; Valenciano, J.

Mild hybrid vehicles with 42 V electrical systems require advanced batteries with low cost, very high reliability and peak power performance. Valve-regulated lead-acid (VRLA) batteries could provide better performance/cost ratio than any other electrochemical couples, by improving their cycle life performance at partial state-of-charge (SoC), charge acceptance of the negative plate and thermal management under power assist conditions. Modular wound designs are being developed for this application, because they can combine the best attributes of the high power VRLA designs (low resistance and high compression) with a more efficient thermal management and could improve reliability by reducing the potential cell failures in manufacturing (better quality control could be assured for individual 3-cell modules than for complete 18-cell block batteries). Thermal management is an important issue for VRLA batteries in a power assist cycling profile. Although water cooling is very efficient, it is not economical and increases the weight of the complete storage system. The modular VRLA design allows air circulation around the external walls of every cell in order to maintain the temperature around 40 °C, even at very high power cycling profiles. In order to increase the life at higher depth-of-discharge (DoD) and consequently to optimise the weight of the complete battery systems, a new 6 V module has been designed with improved thermal management features. Cycle life performance under partial-SoC conditions (around 60% SoC) has been tested in both 6 and 12 V modules. The basic power assist profile as specified by the European car manufacturers is composed of a high power discharge (boost) period followed by a rest (cruise) and recharge in three steps (regenerative braking). Very good results have been obtained for 12 V VRLA spiral wound batteries under power assist profile (more than 200,000 cycles at 1.25% DoD, equivalent to 2500 times the nominal capacity), but smaller 6 V modules, although providing very promising results (50,000 power assist cycles at 2.5% DoD, equivalent to 1250 times the nominal capacity), still need further improvement to comply with the very demanding conditions of mild hybrid vehicles. Failure mode is related to negative active material sulfation, that could be overcome by improving charge acceptance with high surface conducting additives in the active material.

The complexities and pitfalls of working with the countertransference.

PubMed

Rosenbloom, S

1998-04-01

The author attempts to demonstrate that the usual manner of reporting countertransference experiences does not do justice to the complexity of these phenomena. Clinical illustrations are used to show that the data of countertransferences are partial, often difficult to use immediately in analyses, sometimes ambiguous, and hard to validate. The fate of persistent conflictual residues within each analyst is discussed in the context of the life cycle of psychoanalytic work.

Architecture earth-sheltered buildings: Design Manual 1.4

NASA Astrophysics Data System (ADS)

1984-03-01

Design guidance is presented for use by experienced engineers and architects. The types of buildings within the scope of this manual include slab-on-grade, partially-buried (bermed) or fully-buried, and large (single-story or multistory) structures. New criteria unique to earth-sheltered design are included for the following disciplines: Planning, Landscape Design, Life-Cycle Analysis, Architectural, Structural, Mechanical (criteria include below-grade heat flux calculation procedures), and Electrical.

Corrosion-fatigue life of commercially pure titanium and Ti-6Al-4V alloys in different storage environments.

PubMed

Zavanelli, R A; Pessanha Henriques, G E; Ferreira, I; De Almeida Rollo, J M

2000-09-01

Removable partial dentures are affected by fatigue because of the cyclic mechanism of the masticatory system and frequent insertion and removal. Titanium and its alloys have been used in the manufacture of denture frameworks; however, preventive agents with fluorides are thought to attack titanium alloy surfaces. This study evaluated, compared, and analyzed the corrosion-fatigue life of commercially pure titanium and Ti-6Al-4V alloy in different storage environments. For each metal, 33 dumbbell rods, 2.3 mm in diameter at the central segment, were cast in the Rematitan system. Corrosion-fatigue strength test was carried out through a universal testing machine with a load 30% lower than the 0.2% offset yield strength and a combined influence of different environments: in air at room temperature, with synthetic saliva, and with fluoride synthetic saliva. After failure, the number of cycles were recorded, and fracture surfaces were examined with an SEM. ANOVA and Tukey's multiple comparison test indicated that Ti-6Al-4V alloy achieved 21,269 cycles (SD = 8,355) against 19,157 cycles (SD = 3, 624) for the commercially pure Ti. There were no significant differences between either metal in the corrosion-fatigue life for dry specimens, but when the solutions were present, the fatigue life was significantly reduced, probably because of the production of corrosion pits caused by superficial reactions.

Inborn Errors of Metabolism with Hyperammonemia: Urea Cycle Defects and Related Disorders.

PubMed

Summar, Marshall L; Mew, Nicholas Ah

2018-04-01

The urea cycle disorders are a group of inherited biochemical diseases caused by a complete or partial deficiency of any one of the enzymes or transport proteins required to convert toxic ammonia into urea and to produce arginine and citrulline. The clinical manifestations of these disorders are mostly the result of acute or chronic hyperammonemia, which affects the central nervous system. Affected individuals can also develop hepatic dysfunction. These disorders can present at any age from the immediate newborn to later in life. Early diagnosis and treatment are key to improving outcomes. Copyright © 2017 Elsevier Inc. All rights reserved.

Application of Different Statistical Techniques in Integrated Logistics Support of the International Space Station Alpha

NASA Technical Reports Server (NTRS)

Sepehry-Fard, F.; Coulthard, Maurice H.

1995-01-01

The process to predict the values of the maintenance time dependent variable parameters such as mean time between failures (MTBF) over time must be one that will not in turn introduce uncontrolled deviation in the results of the ILS analysis such as life cycle cost spares calculation, etc. A minor deviation in the values of the maintenance time dependent variable parameters such as MTBF over time will have a significant impact on the logistics resources demands, International Space Station availability, and maintenance support costs. It is the objective of this report to identify the magnitude of the expected enhancement in the accuracy of the results for the International Space Station reliability and maintainability data packages by providing examples. These examples partially portray the necessary information hy evaluating the impact of the said enhancements on the life cycle cost and the availability of the International Space Station.

Effects of cerium on the hydrogen absorption-desorption properties of rare earth-Mg-Ni hydrogen-absorbing alloys

NASA Astrophysics Data System (ADS)

Yasuoka, Shigekazu; Ishida, Jun; Kishida, Kyosuke; Inui, Haruyuki

2017-04-01

The influence of Ce addition on the phase constitution, microstructure, hydrogen absorption/desorption properties and battery performances of newly developed rare earth (RE)-Mg-Ni hydrogen-absorbing superlattice alloys for negative electrode materials in Ni-metal hydride (MH) batteries were investigated. The partial substitution of RE (La and Nd) with Ce results in a higher discharge performance and a lower cycle life in the battery. The Ce addition greatly affects the phase constitution, which is mainly characterized by increased formation of the AB2 phase (A = RE or Mg and B = Ni or Al). The existence of the AB2 phase is found to accelerate alloy pulverization and oxidation when the alloys are used as negative electrode materials in Ni-MH model cells. The accelerated pulverization and oxidation are considered to be responsible for the observed higher discharge performance and lower cycle life in the batteries, respectively.

Effects of complex life cycles on genetic diversity: cyclical parthenogenesis

PubMed Central

Rouger, R; Reichel, K; Malrieu, F; Masson, J P; Stoeckel, S

2016-01-01

Neutral patterns of population genetic diversity in species with complex life cycles are difficult to anticipate. Cyclical parthenogenesis (CP), in which organisms undergo several rounds of clonal reproduction followed by a sexual event, is one such life cycle. Many species, including crop pests (aphids), human parasites (trematodes) or models used in evolutionary science (Daphnia), are cyclical parthenogens. It is therefore crucial to understand the impact of such a life cycle on neutral genetic diversity. In this paper, we describe distributions of genetic diversity under conditions of CP with various clonal phase lengths. Using a Markov chain model of CP for a single locus and individual-based simulations for two loci, our analysis first demonstrates that strong departures from full sexuality are observed after only a few generations of clonality. The convergence towards predictions made under conditions of full clonality during the clonal phase depends on the balance between mutations and genetic drift. Second, the sexual event of CP usually resets the genetic diversity at a single locus towards predictions made under full sexuality. However, this single recombination event is insufficient to reshuffle gametic phases towards full-sexuality predictions. Finally, for similar levels of clonality, CP and acyclic partial clonality (wherein a fixed proportion of individuals are clonally produced within each generation) differentially affect the distribution of genetic diversity. Overall, this work provides solid predictions of neutral genetic diversity that may serve as a null model in detecting the action of common evolutionary or demographic processes in cyclical parthenogens (for example, selection or bottlenecks). PMID:27436524

Development of a VRLA battery with improved separators, and a charge controller, for low cost photovoltaic and wind powered installations

NASA Astrophysics Data System (ADS)

Fernandez, M.; Ruddell, A. J.; Vast, N.; Esteban, J.; Estela, F.

There are many applications and uses for which it is more advantageous to use solar installations than to extend the electrical network and connect to it. This kind of applications are numerous covering from isolated houses to telephone repeaters and the like. These kind of applications share some common characteristics like being located in remote not easy accessible areas, require relatively low power for operation, and being difficult to maintain. Up to now the use of photovoltaic systems, no matter the impressive growth they are experimenting, suffer from some drawbacks, mainly related with the life expectations and reliability of such systems, and as a consequence of the cost of these systems, when calculated on a lifetime basis. To try to contribute to solve these problems, a project partially founded by the European Commission, has been carried out, with the main objective of increasing the life of these systems, and consequently to make them more attractive from the point of view of cost on a lifetime basis for consumers. Presently, the life of PV systems is limited by its weakest component, the battery. Battery failure modes in PV applications, are related with well known phenomena like corrosion, but also due to the special nature of this installations, with other factors like corrosion and growth in the upper part of the group, induced by the development of acid stratification inside the battery, with the more prone standard flooded types now in major use, and to a lesser extent the new valve regulated lead acid (VRLA) types beginning to be used. The main objectives of this project, were: to develop a new glass microfibre separator material, capable of minimizing acid stratification inside the battery. To develop a new VRLA battery, with a life duration of 800 cycles on cycling at 60% DOD and partial state of charge (PSOC) conditions. To develop a new charge regulator, that takes into account the condition of the battery in the near term, to modify its setting charging point. The fourth objective was the design and implementation of a PV/wind demonstration system, to test all the PV components under real conditions. The project has been successful, having achieved a life increase of 50%, moving achievable life from previous 500-750 cycles for the new battery and system.

Renewables-to-reefs? - Decommissioning options for the offshore wind power industry.

PubMed

Smyth, Katie; Christie, Nikki; Burdon, Daryl; Atkins, Jonathan P; Barnes, Richard; Elliott, Michael

2015-01-15

The offshore wind power industry is relatively new but increasing globally, hence it is important that the whole life-cycle is managed. The construction-operation-decommissioning cycle is likely to take 20-30 years and whilst decommissioning may not be undertaken for many years, its management needs to be addressed in both current and future marine management regimes. This can be defined within a Drivers-Activities-Pressures-State Changes-Impacts (on human Welfare)-Responses framework. This paper considers the main decommissioning options - partial or complete removal of all components. A SWOT analysis shows environmental and economic benefits in partial as opposed to complete removal, especially if habitat created on the structures has conservation or commercial value. Benefits (and repercussions) are defined in terms of losses and gains of ecosystem services and societal benefits. The legal precedents and repercussions of both options are considered in terms of the 10-tenets of sustainable marine management. Finally a 'renewables-to-reefs' programme is proposed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Effects of Coatings on the High-Cycle Fatigue Life of Threaded Steel Samples

NASA Astrophysics Data System (ADS)

Eder, M. A.; Haselbach, P. U.; Mishin, O. V.

2018-05-01

In this work, high-cycle fatigue is studied for threaded cylindrical high-strength steel samples coated using three different industrial processes: black oxidation, normal-temperature galvanization and high-temperature galvanization. The fatigue performance in air is compared with that of uncoated samples. Microstructural characterization revealed the abundant presence of small cracks in the zinc coating partially penetrating into the steel. This is consistent with the observation of multiple crack initiation sites along the thread in the galvanized samples, which led to crescent type fracture surfaces governed by circumferential growth. In contrast, the black oxidized and uncoated samples exhibited a semicircular segment type fracture surface governed by single-sided growth with a significantly longer fatigue life. Numerical fatigue life prediction based on an extended Paris-law formulation has been conducted on two different fracture cases: 2D axisymmetric multisided crack growth and 3D single-sided crack growth. The results of this upper-bound and lower-bound approach are in good agreement with experimental data and can potentially be used to predict the lifetime of bolted components.

Development of advanced fuel cell system, phase 2

NASA Technical Reports Server (NTRS)

Handley, L. M.; Meyer, A. P.; Bell, W. F.

1973-01-01

A multiple task research and development program was performed to improve the weight, life, and performance characteristics of hydrogen-oxygen alkaline fuel cells for advanced power systems. Development and characterization of a very stable gold alloy catalyst was continued from Phase I of the program. A polymer material for fabrication of cell structural components was identified and its long term compatibility with the fuel cell environment was demonstrated in cell tests. Full scale partial cell stacks, with advanced design closed cycle evaporative coolers, were tested. The characteristics demonstrated in these tests verified the feasibility of developing the engineering model system concept into an advanced lightweight long life powerplant.

Low Cycle Fatigue and Creep-Fatigue Behavior of Alloy 617 at High Temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabet, Celine; Carroll, Laura; Wright, Richard

Alloy 617 is the leading candidate material for an intermediate heat exchanger (IHX) application of the Very High Temperature Nuclear Reactor (VHTR), expected to have an outlet temperature as high as 950 degrees C. Acceptance of Alloy 617 in Section III of the ASME Code for nuclear construction requires a detailed understanding of the creep-fatigue behavior. Initial creep-fatigue work on Alloy 617 suggests a more dominant role of environment with increasing temperature and/or hold times evidenced through changes in creep-fatigue crack growth mechanism/s and failure life. Continuous cycle fatigue and creep-fatigue testing of Alloy 617 was conducted at 950 degreesmore » C and 0.3% and 0.6% total strain in air to simulate damage modes expected in a VHTR application. Continuous cycle specimens exhibited transgranular cracking. Intergranular cracking was observed in the creep-fatigue specimens, although evidence of grain boundary cavitation was not observed. Despite the absence of grain boundary cavitation to accelerate crack propagation, the addition of a hold time at peak tensile strain was detrimental to cycle life. This suggests that creepfatigue interaction may occur by a different mechanism or that the environment may be partially responsible for accelerating failure.« less

Evaluation of 20 Ah Li Ion Cells

NASA Technical Reports Server (NTRS)

Smart, Marshall; Ratnakumar, B. V.; Huang, Charles K.; Surampudi, S.; Hill, Carole; Radzykewycz, Dan T.; Marsh, Richard A.

1998-01-01

Lithium ion cells of 20 Ah capacity were fabricated by Bluestar Advanced Technology Corporation, Canada under a developmental contract from US Air Force. In this paper, we report our studies on the evaluation of these cells under various test conditions. These include generic test conditions such as discharges and charges at different temperatures to understand the rate-limiting processes in the discharge/charge processes as a function of temperature, and cycle life under standard cycling conditions (100% DOD) at ambient temperature. In addition, tests are being done to ascertain the performance of the cells in the Mars 2001 Lander application, which includes pulse testing of the cells at 60 A and 40 A loads for 100 mS and 1 min., respectively at different states of charge and temperatures, and cycling at low temperature at partial depths of discharge.

Lightweight Materials for Automotive Application: An Assessment of Material Production Data for Magnesium and Carbon Fiber

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, M. C.; Sullivan, J. L.

The use of lightweight materials in vehicle components, also known as “lightweighting,” can result in automobile weight reduction, which improves vehicle fuel economy and generally its environmental footprint. Materials often used for vehicle lightweighting include aluminum, magnesium, and polymers reinforced with either glass or carbon fiber. However, because alternative materials typically used for vehicle lightweighting require more energy to make on a per part basis than the material being replaced (often steel or iron), the fuel efficiency improvement induced by a weight reduction is partially offset by an increased energy for the vehicle material production. To adequately quantify this tradeoff,more » reliable and current values for life-cycle production energy are needed for both conventional and alternative materials. Our focus here is on the production of two such alternative materials: magnesium and carbon fibers. Both these materials are low density solids with good structural properties. These properties have enabled their use in applications where weight is an issue, not only for automobiles but also for aerospace applications. This report addresses the predominant production methods for these materials and includes a tabulation of available material and energy input data necessary to make them. The life cycle inventory (LCI) information presented herein represents a process chain analysis (PCA) approach to life cycle assessment (LCA) and is intended for evaluation as updated materials production data for magnesium and carbon fiber for inclusion into the Greenhouse gases, Regulated Emissions, and Energy use in Transportation model (GREET2_2012). The summary life-cycle metrics used to characterize the cradle-to-gate environmental performance of these materials are the cumulative energy demand (CED) and greenhouse gas emissions (GHG) per kilogram of material.« less

Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle.

PubMed

Chaal, Balbir K; Gupta, Archna P; Wastuwidyaningtyas, Brigitta D; Luah, Yen-Hoon; Bozdech, Zbynek

2010-01-22

The apparent paucity of molecular factors of transcriptional control in the genomes of Plasmodium parasites raises many questions about the mechanisms of life cycle regulation in these malaria parasites. Epigenetic regulation has been suggested to play a major role in the stage specific gene expression during the Plasmodium life cycle. To address some of these questions, we analyzed global transcriptional responses of Plasmodium falciparum to a potent inhibitor of histone deacetylase activities (HDAC). The inhibitor apicidin induced profound transcriptional changes in multiple stages of the P. falciparum intraerythrocytic developmental cycle (IDC) that were characterized by rapid activation and repression of a large percentage of the genome. A major component of this response was induction of genes that are otherwise suppressed during that particular stage of the IDC or specific for the exo-erythrocytic stages. In the schizont stage, apicidin induced hyperacetylation of histone lysine residues H3K9, H4K8 and the tetra-acetyl H4 (H4Ac4) and demethylation of H3K4me3. Interestingly, we observed overlapping patterns of chromosomal distributions between H4K8Ac and H3K4me3 and between H3K9Ac and H4Ac4. There was a significant but partial association between the apicidin-induced gene expression and histone modifications, which included a number of stage specific transcription factors. Taken together, inhibition of HDAC activities leads to dramatic de-regulation of the IDC transcriptional cascade, which is a result of both disruption of histone modifications and up-regulation of stage specific transcription factors. These findings suggest an important role of histone modification and chromatin remodeling in transcriptional regulation of the Plasmodium life cycle. This also emphasizes the potential of P. falciparum HDACs as drug targets for malaria chemotherapy.

A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation

PubMed Central

Dittmann, Meike; Hoffmann, Hans-Heinrich; Scull, Margaret A.; Gilmore, Rachel H.; Bell, Kierstin L.; Ciancanelli, Michael; Wilson, Sam J.; Crotta, Stefania; Yu, Yingpu; Flatley, Brenna; Xiao, Jing W.; Casanova, Jean-Laurent; Wack, Andreas; Bieniasz, Paul D.; Rice, Charles M.

2015-01-01

Summary Interferon-stimulated genes (ISGs) act in concert to provide a tight barrier against viruses. Recent studies have shed light on the contribution of individual ISG effectors to the antiviral state, but most have examined those acting on early, intracellular stages of the viral life cycle. Here, we applied an image-based screen to identify ISGs inhibiting late stages of influenza A virus (IAV) infection. We unraveled a directly antiviral function for the gene SERPINE1, encoding plasminogen activator inhibitor 1 (PAI-1). By targeting extracellular airway proteases, PAI-1 inhibits IAV glycoprotein cleavage, thereby reducing infectivity of progeny viruses. This was biologically relevant for IAV restriction in vivo. Further, partial PAI-1 deficiency, attributable to a polymorphism in human SERPINE1, conferred increased susceptibility to IAV in vitro. Together, our findings reveal that manipulating the extracellular environment to inhibit the last step in a virus life cycle is an important mechanism of the antiviral response. PMID:25679759

Bioproducts and environmental quality: Biofuels, greenhouse gases, and water quality

NASA Astrophysics Data System (ADS)

Ren, Xiaolin

Promoting bio-based products is one oft-proposed solution to reduce GHG emissions because the feedstocks capture carbon, offsetting at least partially the carbon discharges resulting from use of the products. However, several life cycle analyses point out that while biofuels may emit less life cycle net carbon emissions than fossil fuels, they may exacerbate other parts of biogeochemical cycles, notably nutrient loads in the aquatic environment. In three essays, this dissertation explores the tradeoff between GHG emissions and nitrogen leaching associated with biofuel production using general equilibrium models. The first essay develops a theoretical general equilibrium model to calculate the second-best GHG tax with the existence of a nitrogen leaching distortion. The results indicate that the second-best GHG tax could be higher or lower than the first-best tax rates depending largely on the elasticity of substitution between fossil fuel and biofuel. The second and third essays employ computable general equilibrium models to further explore the tradeoff between GHG emissions and nitrogen leaching. The computable general equilibrium models also incorporate multiple biofuel pathways, i.e., biofuels made from different feedstocks using different processes, to identify the cost-effective combinations of biofuel pathways under different policies, and the corresponding economic and environmental impacts.

The Discriminant Value of Phase-Dependent Local Dynamic Stability of Daily Life Walking in Older Adult Community-Dwelling Fallers and Nonfallers

PubMed Central

Ihlen, Espen A. F.; Weiss, Aner; Helbostad, Jorunn L.; Hausdorff, Jeffrey M.

2015-01-01

The present study compares phase-dependent measures of local dynamic stability of daily life walking with 35 conventional gait features in their ability to discriminate between community-dwelling older fallers and nonfallers. The study reanalyzes 3D-acceleration data of 3-day daily life activity from 39 older people who reported less than 2 falls during one year and 31 who reported two or more falls. Phase-dependent local dynamic stability was defined for initial perturbation at 0%, 20%, 40%, 60%, and 80% of the step cycle. A partial least square discriminant analysis (PLS-DA) was used to compare the discriminant abilities of phase-dependent local dynamic stability with the discriminant abilities of 35 conventional gait features. The phase-dependent local dynamic stability λ at 0% and 60% of the step cycle discriminated well between fallers and nonfallers (AUC = 0.83) and was significantly larger (p < 0.01) for the nonfallers. Furthermore, phase-dependent λ discriminated as well between fallers and nonfallers as all other gait features combined. The present result suggests that phase-dependent measures of local dynamic stability of daily life walking might be of importance for further development in early fall risk screening tools. PMID:26491669

Life strategies of a ubiquitous and abundant subsurface archaeal group Bathyarchaeota

NASA Astrophysics Data System (ADS)

He, Y.; Li, M.; Perumal, V.; Feng, X.; Sievert, S. M.; Wang, F.

2015-12-01

Archaea belonging to the Miscellaneous Crenarchaeota Group (MCG, "Candidatus Bathyarchaeota") are widespread and abundant in the deep biosphere, yet their life strategies and ecological roles remain elusive. Metagenomic sequencing of a sample enriched in Bathyarchaeota (up to 74%) that originated from Guaymas Basin deep-sea vent sediments revealed 6 partial to nearly completed Bathyarchaeota genomic bins. ranging ~900kb-3.3Mb. The Bathyarchaeota bin size ranged from approximately 0.9 to 3.3 Mb, with coverage ranging from approximately 10× to 28×. The phylogeny based on 110 concatenated conserved archaeal single copy genes confirmed the placement of Bathyarchaeota into a novel archaeal phylum. Genes encoding for enzymes involved in the degradation of organic polymers such as protein, cellulose, chitin, and aromatic compounds, were identified. In addition, genes encoding glycolysis/gluconeogenesis, beta-oxidation pathways and the tricarboxylic acid cycle (except citrate synthase) were present in all genomic bins highlighting the heterotrophic life style of Bathyarchaeota. The presence of a wide variety of transporters of organic compounds further supports the versatile heterotrophic metabolism of Bathyarchaeota. This study highlights the life strategies of a ubiquitous and abundant subsurface archaeal group that thrives under energy-limited conditions, and expands the metabolic potentials of Archaea that play important roles in carbon cycling in marine sediments.

Comparison of transcript profiles in different life stages of the nematode Globodera pallida under different host potato genotypes.

PubMed

Palomares-Rius, Juan E; Hedley, Pete E; Cock, Peter J A; Morris, Jenny A; Jones, John T; Vovlas, Nikos; Blok, Vivian

2012-12-01

The potato cyst nematodes (PCNs) Globodera pallida and Globodera rostochiensis are important parasites of potato. PCNs undergo complex biotrophic interactions with their hosts that involve gene expression changes in both the nematode and the host plant. The aim of this study was to determine key genes that are differentially expressed in Globodera pallida life cycle stages and during the initiation of the feeding site in susceptible and partially resistant potato genotypes. For this purpose, two microarray experiments were designed: (i) a comparison of eggs, infective second-stage juveniles (J2s) and sedentary parasitic-stage J2s (SJ2); (ii) a comparison of SJ2s at 8 days after inoculation (DAI) in the susceptible cultivar (Desirée) and two partially resistant lines. The results showed differential expression of G. pallida genes during the stages studied, including previously characterized effectors. In addition, a large number of genes changed their expression between SJ2s in the susceptible cultivar and those infecting partially resistant lines; the number of genes with modified expression was lower when the two partially resistant lines were compared. Moreover, a histopathological study was performed at several time points (7, 14 and 30 DAI) and showed the similarities between both partially resistant lines with a delay and degeneration in the formation of the syncytia in comparison with the susceptible cultivar. Females at 30 DAI in partially resistant lines showed a delay in their development in comparison with those in the susceptible cultivar. © 2012 THE AUTHORS. MOLECULAR PLANT PATHOLOGY © 2012 BSPP AND BLACKWELL PUBLISHING LTD.

Relaxed selection causes microevolution of seawater osmoregulation and gene expression in landlocked Alewives

USGS Publications Warehouse

Velotta, Jonathan P.; McCormick, Stephen D.; O'Neill, Rachel J.; Schultz, Eric T.

2014-01-01

Ecological transitions from marine to freshwater environments have been important in the creation of diversity among fishes. Evolutionary changes associated with these transitions likely involve modifications of osmoregulatory function. In particular, relaxed selection on hypo-osmoregulation should strongly affect animals that transition into novel freshwater environments. We used populations of the Alewife (Alosa pseudoharengus) to study evolutionary shifts in hypo-osmoregulatory capacity and ion regulation associated with freshwater transitions. Alewives are ancestrally anadromous, but multiple populations in Connecticut have been independently restricted to freshwater lakes; these landlocked populations complete their entire life cycle in freshwater. Juvenile landlocked and anadromous Alewives were exposed to three salinities (1, 20 and 30 ppt) in small enclosures within the lake. We detected strong differentiation between life history forms: landlocked Alewives exhibited reduced seawater tolerance and hypo-osmoregulatory performance compared to anadromous Alewives. Furthermore, gill Na+/K+-ATPase activity and transcription of genes for seawater osmoregulation (NKCC—Na+/K+/2Cl− cotransporter and CFTR—cystic fibrosis transmembrane conductance regulator) exhibited reduced responsiveness to seawater challenge. Our study demonstrates that adaptations of marine-derived species to completely freshwater life cycles involve partial loss of seawater osmoregulatory performance mediated through changes to ion regulation in the gill.

Long-term effects of antibiotics, norfloxacin, and sulfamethoxazole, in a partial life-cycle study with zebrafish (Danio rerio): effects on growth, development, and reproduction.

PubMed

Yan, Zhenhua; Lu, Guanghua; Ye, Qiuxia; Liu, Jianchao

2016-09-01

A partial life-cycle study with zebrafish (Danio rerio) was conducted to evaluate the long-term effects of antibiotics, norfloxacin (NOR) and sulfamethoxazole (SMX). A series of bio-endpoints correlated to the growth, development, and reproduction was assessed. The results showed that the body weight and the condition factor were depressed by SMX at 200 μg/L during the growth period. Meanwhile, the activities of metabolic enzyme (ethoxyresorufin O-deethylase, EROD) and antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT) were stimulated in all cases. The consequences of parental exposure to antibiotics for the next generation were also examined. The egg production of parents were depressed by the 200 μg/L NOR and SMX alone or in combination. Similarly, decreased hatching, survival, and enhanced development abnormality of the next generation also occurred after parental exposure to SMX at the highest concentration. The heartbeat however was not altered in all cases. Furthermore, there was no significant difference in the bio-endpoints between the combined and individual treatment in most cases, with the exception of lower EROD activity and egg production in the co-treatment. The results suggest that long-term exposure to NOR and SMX at environmentally relevant concentrations, individually and in a mixture, may not significantly pose a threat to the growth, development, and reproduction of zebrafish, and an adverse effect may be expected at high concentration.

Delving into the environmental aspect of a Sardinian white wine: from partial to total life cycle assessment.

PubMed

Fusi, Alessandra; Guidetti, Riccardo; Benedetto, Graziella

2014-02-15

The aim of this study was to deepen the assessment of the environmental impacts of a white wine produced in Sardinia (FU 750 ml), performing an attributional LCA. The system boundaries were extended, from 'cradle to gate' (partial LCA) of a previous study, to 'cradle to grave' (total LCA), in order to identify the environmental impacts occurring along the wine life cycle stages (vine planting, grape production, wine production, bottling and packaging, distribution, final disposal of the glass bottle). Some assumptions were made in order to quantify the environmental impact of the transportation phase, regarding the few data which were available. Inventory data were mainly collected through direct communication with the Company involved in the study. Results showed that the environmental performance of wine was mostly determined by the glass bottle production (for all impact categories except ozone layer depletion). The second contributor was the agricultural phase, which included two sub-phases: vine planting and grape production. Results showed that the vine planting sub-phase was not negligible given its contribution to the agricultural phase, mainly due to diesel fuel consumption. Transportation impact was found to be relevant for long distance distribution (USA); the impact categories more affected by transport were acidification, eutrophication, photochemical oxidation and global warming potential. Suggested opportunities to reduce the overall environmental impact were the introduction of a lighter glass bottle or the substitution of the glass bottle with a polylaminate container. Copyright © 2013 Elsevier B.V. All rights reserved.

Effects of oxygen partial pressure on Li-air battery performance

NASA Astrophysics Data System (ADS)

Kwon, Hyuk Jae; Lee, Heung Chan; Ko, Jeongsik; Jung, In Sun; Lee, Hyun Chul; Lee, Hyunpyo; Kim, Mokwon; Lee, Dong Joon; Kim, Hyunjin; Kim, Tae Young; Im, Dongmin

2017-10-01

For application in electric vehicles (EVs), the Li-air battery system needs an air intake system to supply dry oxygen at controlled concentration and feeding rate as the cathode active material. To facilitate the design of such air intake systems, we have investigated the effects of oxygen partial pressure (≤1 atm) on the performance of the Li-air cell, which has not been systematically examined. The amounts of consumed O2 and evolved CO2 from the Li-air cell are measured with a custom in situ differential electrochemical gas chromatography-mass spectrometry (DEGC-MS). The amounts of consumed O2 suggest that the oxygen partial pressure does not affect the reaction mechanism during discharge, and the two-electron reaction occurs under all test conditions. On the other hand, the charging behavior varies by the oxygen partial pressure. The highest O2 evolution ratio is attained under 70% O2, along with the lowest CO2 evolution. The cell cycle life also peaks at 70% O2 condition. Overall, an oxygen partial pressure of about 0.5-0.7 atm maximizes the Li-air cell capacity and stability at 1 atm condition. The findings here indicate that the appropriate oxygen partial pressure can be a key factor when developing practical Li-air battery systems.

Characterization of a novel ADAM protease expressed by Pneumocystis carinii.

PubMed

Kennedy, Cassie C; Kottom, Theodore J; Limper, Andrew H

2009-08-01

Pneumocystis species are opportunistic fungal pathogens that cause severe pneumonia in immunocompromised hosts. Recent evidence has suggested that unidentified proteases are involved in Pneumocystis life cycle regulation. Proteolytically active ADAM (named for "a disintegrin and metalloprotease") family molecules have been identified in some fungal organisms, such as Aspergillus fumigatus and Schizosaccharomyces pombe, and some have been shown to participate in life cycle regulation. Accordingly, we sought to characterize ADAM-like molecules in the fungal opportunistic pathogen, Pneumocystis carinii (PcADAM). After an in silico search of the P. carinii genomic sequencing project identified a 329-bp partial sequence with homology to known ADAM proteins, the full-length PcADAM sequence was obtained by PCR extension cloning, yielding a final coding sequence of 1,650 bp. Sequence analysis detected the presence of a typical ADAM catalytic active site (HEXXHXXGXXHD). Expression of PcADAM over the Pneumocystis life cycle was analyzed by Northern blot. Southern and contour-clamped homogenous electronic field blot analysis demonstrated its presence in the P. carinii genome. Expression of PcADAM was observed to be increased in Pneumocystis cysts compared to trophic forms. The full-length gene was subsequently cloned and heterologously expressed in Saccharomyces cerevisiae. Purified PcADAMp protein was proteolytically active in casein zymography, requiring divalent zinc. Furthermore, native PcADAMp extracted directly from freshly isolated Pneumocystis organisms also exhibited protease activity. This is the first report of protease activity attributable to a specific, characterized protein in the clinically important opportunistic fungal pathogen Pneumocystis.

Elucidation of the first definitively identified life cycle for a marine turtle blood fluke (Trematoda: Spirorchiidae) enables informed control.

PubMed

Cribb, Thomas H; Crespo-Picazo, Jose L; Cutmore, Scott C; Stacy, Brian A; Chapman, Phoebe A; García-Párraga, Daniel

2017-01-01

Blood flukes of the family Spirorchiidae are significant pathogens of both free-ranging and captive marine turtles. Despite a significant proportion of marine turtle mortality being attributable to spirorchiid infections, details of their life cycles remain almost entirely unknown. Here we report on the molecular elucidation of the complete life cycle of a marine spirorchiid, identified as Amphiorchis sp., infecting vermetid gastropods and captive hatched neonate Caretta caretta in the Oceanogràfic Aquarium, in Valencia, Spain. Specimens of a vermetid gastropod, Thylaeodus cf. rugulosus (Monterosato, 1878), collected from the aquarium filtration system housing diseased C. caretta, were infected with sporocysts and cercariae consistent with the family Spirorchiidae. We generated rDNA sequence data [internal transcribed spacer 2 (ITS2) and partial 28S rDNA] from infections from the vermetid which were identical to sequences generated from eggs from the serosa of the intestine of neonate C. caretta, and an adult spirorchiid from the liver of a C. caretta from Florida, USA. Given the reliability of these markers in the delineation of trematode species, we consider all three stages to represent the same species and tentatively identify it as a species of Amphiorchis Price, 1934. The source of infection at the Oceanogràfic Foundation Rehabilitation Centre, Valencia, Spain, is inferred to be an adult C. caretta from the western Mediterranean being rehabilitated in the same facility. Phylogenetic analysis suggests that this Amphiorchis sp. is closely related to other spirorchiids of marine turtles (species of Carettacola Manter & Larson, 1950, Hapalotrema Looss, 1899 and Learedius Price, 1934). We discuss implications of the present findings for the control of spirorchiidiasis in captivity, for the better understanding of epidemiology in wild individuals, and the elucidation of further life cycles. Copyright © 2016 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

Evolution and regulation of complex life cycles: a brown algal perspective.

PubMed

Cock, J Mark; Godfroy, Olivier; Macaisne, Nicolas; Peters, Akira F; Coelho, Susana M

2014-02-01

The life cycle of an organism is one of its fundamental features, influencing many aspects of its biology. The brown algae exhibit a diverse range of life cycles indicating that transitions between life cycle types may have been key adaptive events in the evolution of this group. Life cycle mutants, identified in the model organism Ectocarpus, are providing information about how life cycle progression is regulated at the molecular level in brown algae. We explore some of the implications of the phenotypes of the life cycle mutants described to date and draw comparisons with recent insights into life cycle regulation in the green lineage. Given the importance of coordinating growth and development with life cycle progression, we suggest that the co-option of ancient life cycle regulators to control key developmental events may be a common feature in diverse groups of multicellular eukaryotes. Copyright © 2013 Elsevier Ltd. All rights reserved.

Aqueous hybrid ion batteries - An environmentally friendly alternative for stationary energy storage?

NASA Astrophysics Data System (ADS)

Peters, Jens F.; Weil, Marcel

2017-10-01

Aqueous hybrid ion batteries (AHIB) are being promoted as an environmentally friendly alternative to existing stationary battery technologies. However, no quantification of their potential environmental impacts has yet been done. This paper presents a prospective life cycle assessment of an AHIB module and compares its performance with lithium-ion and sodium-ion batteries in two different stationary energy storage applications. The findings show that the claim of being an environmentally friendly technology can only be supported with some major limitations. While the AHIB uses abundant and non-toxic materials, it has a very low energy density and requires increased amounts of material for providing a given storage capacity. Per kWh of battery, results comparable to those of the alternative lithium- or sodium-ion batteries are obtained, but significantly higher impacts under global warming and ozone depletion aspects. The comparable high cycle life of the AHIB compensates this partially, requiring less battery replacements over the lifetime of the application. On the other hand, its internal inefficiencies are higher, what becomes the dominating factor when charging majorly fossil based electricity, making AHIB unattractive for this type of applications.

The influence of cycling temperature and cycling rate on the phase specific degradation of a positive electrode in lithium ion batteries: A post mortem analysis

NASA Astrophysics Data System (ADS)

Darma, Mariyam Susana Dewi; Lang, Michael; Kleiner, Karin; Mereacre, Liuda; Liebau, Verena; Fauth, Francois; Bergfeldt, Thomas; Ehrenberg, Helmut

2016-09-01

The influence of cycling temperatures and cycling rates on the cycling stability of the positive electrode (cathode) of commercial batteries are investigated. The cathode is a mixture of LiMn2O4 (LMO), LiNi0.5Co0.2Mn0.3O2 (NCM) and LiNi0.8Co0.15Al0.05O2 (NCA). It is found that increasing the cycling temperature from 25 °C to 40 °C is detrimental to the long term cycling stability of the cathode. Contrastingly, the improved cycling stability is observed for the cathodes cycled at higher charge/discharge rate (2C/3C instead of 1C/2C). The microstructure analysis by X-ray powder diffraction reveals that a significant capacity fading and an increased overvoltage is observed for NCM and NCA in all the fatigued cathodes. After high number of cycling (above 1500 cycles), NCM becomes partially inactive. In contrast to NCM and NCA, LMO shows a good cycling stability at 25 °C. A pronounced degradation of LMO is only observed for the fatigued cathodes cycled at 40 °C. The huge capacity losses of NCM and NCA are most likely because the blended cathodes were cycled up to 4.12 V vs. the graphite anode during the cycle-life test (corresponds to 4.16 V vs. Li+/Li); which is beyond the stability limit of the layered oxides below 4.05 V vs. Li+/Li.

High rate partial-state-of-charge operation of VRLA batteries

NASA Astrophysics Data System (ADS)

Moseley, Patrick T.

The world market for 12 V SLI batteries currently stands at around US$ 12 billion. The lack of a serious challenge from other battery types has allowed lead-acid products to serve this market exclusively, with minimal demand for product improvement through research and development, and a sharp competition has, over time, cut sales prices to commodity levels. The electrochemical storage of energy in automobiles now faces the possibility of a major change, in the form of the proposed 36/42 V electrical systems for vehicles that remain primarily powered by internal combustion engines, and of the hybrid electric vehicle. The duty cycle for these two applications sees the battery held at a partial-state-of-charge (PSoC) for most of its life and required to supply, and to accept, charge at unprecedented rates. The remarkable advances achieved with VRLA battery technology for electric vehicles during the past 8-10 years will be of only passing value in overcoming the challenges posed by high rate PSoC service in 36/42 V and HEV duty. This is because the failure modes seen in PSoC are quite different from those faced in EV (deep cycle) use. The replacement of the 12 V SLI will not take place rapidly. However, if the applications which take its place are to be satisfied by a lead-acid product (probably VRLA), rather than by a battery of a different chemistry, a program of development as successful as that mounted for deep cycle duty will be required. The present phase of the Advanced Lead-Acid Battery Consortium (ALABC) R&D program has begun to shed light on those aspects of the function of a VRLA battery which currently limit its life in high rate PSoC duty. The program is also pursuing the several technologies which show promise of overcoming those limits, including multiple tab plate design, mass transport facilitation and minor component (both beneficial and detrimental impurity) management. This paper presents a brief review of the changes which are taking place in lead-acid battery technology in response to the challenges of the new duty cycle.

Method of improving fatigue life of cast nickel based superalloys and composition

DOEpatents

Denzine, Allen F.; Kolakowski, Thomas A.; Wallace, John F.

1978-03-14

The invention consists of a method of producing a fine equiaxed grain structure (ASTM 2-4) in cast nickel-base superalloys which increases low cycle fatigue lives without detrimental effects on stress rupture properties to temperatures as high as 1800.degree. F. These superalloys are variations of the basic nickel-chromium matrix, hardened by gamma prime [Ni.sub.3 (Al, Ti)] but with optional additions of cobalt, tungsten, molybdenum, vanadium, columbium, tantalum, boron, zirconium, carbon and hafnium. The invention grain refines these alloys to ASTM 2 to 4 increasing low cycle fatigue life by a factor of 2 to 5 (i.e. life of 700 hours would be increased to 1400 to 3500 hours for a given stress) as a result of the addition of 0.01% to 0.2% of a member of the group consisting of boron, zirconium and mixtures thereof to aid heterogeneous nucleation. The alloy is vacuum melted and heated to 250.degree.-400.degree. F. above the melting temperature, cooled to partial solidification, thus resulting in said heterogeneous nucleation and fine grains, then reheated and cast at about 50.degree.-100.degree. F. of superheat. Additions of 0.1% boron and 0.1% zirconium (optional) are the preferred nucleating agents.

Waste-to-energy: A review of life cycle assessment and its extension methods.

PubMed

Zhou, Zhaozhi; Tang, Yuanjun; Chi, Yong; Ni, Mingjiang; Buekens, Alfons

2018-01-01

This article proposes a comprehensive review of evaluation tools based on life cycle thinking, as applied to waste-to-energy. Habitually, life cycle assessment is adopted to assess environmental burdens associated with waste-to-energy initiatives. Based on this framework, several extension methods have been developed to focus on specific aspects: Exergetic life cycle assessment for reducing resource depletion, life cycle costing for evaluating its economic burden, and social life cycle assessment for recording its social impacts. Additionally, the environment-energy-economy model integrates both life cycle assessment and life cycle costing methods and judges simultaneously these three features for sustainable waste-to-energy conversion. Life cycle assessment is sufficiently developed on waste-to-energy with concrete data inventory and sensitivity analysis, although the data and model uncertainty are unavoidable. Compared with life cycle assessment, only a few evaluations are conducted to waste-to-energy techniques by using extension methods and its methodology and application need to be further developed. Finally, this article succinctly summarises some recommendations for further research.

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

PubMed Central

Meyer-Hermann, Michael; Osiewacz, Heinz D.

2012-01-01

Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial function and quality control during aging in silico. We demonstrate that cycles of fusion and fission and mitophagy indeed are essential for ensuring a high average quality of mitochondria, even under conditions in which random molecular damage is present. Prompted by earlier observations that mitochondrial fission itself can cause a partial drop in mitochondrial membrane potential, we tested the consequences of mitochondrial dynamics being harmful on its own. Next to directly impairing mitochondrial function, pre-existing molecular damage may be propagated and enhanced across the mitochondrial population by content mixing. In this situation, such an infection-like phenomenon impairs mitochondrial quality control progressively. However, when imposing an age-dependent deceleration of cycles of fusion and fission, we observe a delay in the loss of average quality of mitochondria. This provides a rational why fusion and fission rates are reduced during aging and why loss of a mitochondrial fission factor can extend life span in fungi. We propose the ‘mitochondrial infectious damage adaptation’ (MIDA) model according to which a deceleration of fusion–fission cycles reflects a systemic adaptation increasing life span. PMID:22761564

10 CFR 436.12 - Life cycle cost methodology.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Life cycle cost methodology. 436.12 Section 436.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost methodology...

10 CFR 436.12 - Life cycle cost methodology.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Life cycle cost methodology. 436.12 Section 436.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost methodology...

10 CFR 436.12 - Life cycle cost methodology.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Life cycle cost methodology. 436.12 Section 436.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost methodology...

10 CFR 436.12 - Life cycle cost methodology.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life cycle cost methodology. 436.12 Section 436.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost methodology...

10 CFR 436.19 - Life cycle costs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the...

10 CFR 436.12 - Life cycle cost methodology.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life cycle cost methodology. 436.12 Section 436.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost methodology...

10 CFR 436.19 - Life cycle costs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the...

The evolution of life cycle complexity in aphids: Ecological optimization or historical constraint?

PubMed

Hardy, Nate B; Peterson, Daniel A; von Dohlen, Carol D

2015-06-01

For decades, biologists have debated why many parasites have obligate multihost life cycles. Here, we use comparative phylogenetic analyses of aphids to evaluate the roles of ecological optimization and historical constraint in the evolution of life cycle complexity. If life cycle complexity is adaptive, it should be evolutionarily labile, that is, change in response to selection. We provide evidence that this is true in some aphids (aphidines), but not others (nonaphidines)-groups that differ in the intensity of their relationships with primary hosts. Next, we test specific mechanisms by which life cycle complexity could be adaptive or a constraint. We find that among aphidines there is a strong association between complex life cycles and polyphagy but only a weak correlation between life cycle complexity and reproductive mode. In contrast, among nonaphidines the relationship between life cycle complexity and host breadth is weak but the association between complex life cycles and sexual reproduction is strong. Thus, although the adaptiveness of life cycle complexity appears to be lineage specific, across aphids, life cycle evolution appears to be tightly linked with the evolution of other important natural history traits. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

The role of microstructure and phase distribution in the failure mechanisms and life prediction model for PSZ coatings

NASA Technical Reports Server (NTRS)

Sisson, R. D., Jr.; Sone, Ichiro; Biederman, R. R.

1985-01-01

Partially Stabilized Zirconia (PSZ) may become widely used for Thermal Barrier Coatings (TBC). Failure of these coatings can occur due to thermal fatigue in oxidizing atmospheres. The failure is due to the strains that develop due to thermal gradients, differences in thermal expansion coefficients, and oxidation of the bond coating. The role of microstructure and the cubic, tetragonal, and monoclinic phase distribution in the strain development and subsequent failure will be discussed. An X-ray diffraction technique for accurate determination of the fraction of each phase in PSZ will be applied to understanding the phase transformations and strain development. These results will be discussed in terms of developing a model for life prediction in PSZ coatings during thermal cycling.

High-speed optical phase-shifting apparatus

DOEpatents

Zortman, William A.

2016-11-08

An optical phase shifter includes an optical waveguide, a plurality of partial phase shifting elements arranged sequentially, and control circuitry electrically coupled to the partial phase shifting elements. The control circuitry is adapted to provide an activating signal to each of the N partial phase shifting elements such that the signal is delayed by a clock cycle between adjacent partial phase shifting elements in the sequence. The transit time for a guided optical pulse train between the input edges of consecutive partial phase shifting elements in the sequence is arranged to be equal to a clock cycle, thereby enabling pipelined processing of the optical pulses.

Biogeographic variation in evergreen conifer needle longevity and impacts on boreal forest carbon cycle projections

PubMed Central

Reich, Peter B.; Rich, Roy L.; Lu, Xingjie; Wang, Ying-Ping; Oleksyn, Jacek

2014-01-01

Leaf life span is an important plant trait associated with interspecific variation in leaf, organismal, and ecosystem processes. We hypothesized that intraspecific variation in gymnosperm needle traits with latitude reflects both selection and acclimation for traits adaptive to the associated temperature and moisture gradient. This hypothesis was supported, because across 127 sites along a 2,160-km gradient in North America individuals of Picea glauca, Picea mariana, Pinus banksiana, and Abies balsamea had longer needle life span and lower tissue nitrogen concentration with decreasing mean annual temperature. Similar patterns were noted for Pinus sylvestris across a north–south gradient in Europe. These differences highlight needle longevity as an adaptive feature important to ecological success of boreal conifers across broad climatic ranges. Additionally, differences in leaf life span directly affect annual foliage turnover rate, which along with needle physiology partially regulates carbon cycling through effects on gross primary production and net canopy carbon export. However, most, if not all, global land surface models parameterize needle longevity of boreal evergreen forests as if it were a constant. We incorporated temperature-dependent needle longevity and %nitrogen, and biomass allocation, into a land surface model, Community Atmosphere Biosphere Land Exchange, to assess their impacts on carbon cycling processes. Incorporating realistic parameterization of these variables improved predictions of canopy leaf area index and gross primary production compared with observations from flux sites. Finally, increasingly low foliage turnover and biomass fraction toward the cold far north indicate that a surprisingly small fraction of new biomass is allocated to foliage under such conditions. PMID:25225397

Nutritional Combined Greenhouse Gas Life Cycle Analysis for Incorporating Canadian Yellow Pea into Cereal-Based Food Products

PubMed Central

Marinangeli, Christopher P. F.; Tremorin, Denis

2018-01-01

Incorporating low cost pulses, such as yellow peas, that are rich in nutrients and low in fertilizer requirements, into daily food items, can improve the nutritional and sustainability profile of national diets. This paper systematically characterized the effect of using Canadian grown whole yellow pea and refined wheat flours on nutritional density and carbon footprint in cereal-based food products. Canada-specific production data and the levels of 27 macro- and micronutrients were used to calculate the carbon footprint and nutrient balance score (NBS), respectively, for traditional and reformulated pan bread, breakfast cereal, and pasta. Results showed that partial replacement of refined wheat flour with yellow pea flour increased the NBS of pan bread, breakfast cereal, and pasta by 11%, 70%, and 18%, and decreased the life cycle carbon footprint (kg CO2 eq/kg) by 4%, 11%, and 13%, respectively. The cultivation stage of wheat and yellow peas, and the electricity used during the manufacturing stage of food production, were the hotspots in the life cycle. The nutritional and greenhouse gas (GHG) data were combined as the nutrition carbon footprint score (NCFS) (NBS/g CO2 per serving), a novel indicator that reflects product-level nutritional quality per unit environmental impact. Results showed that yellow pea flour increased the NCFS by 15% for pan bread, 90% for breakfast cereal, and 35% for pasta. The results and framework of this study are relevant for food industry, consumers, as well as global and national policy-makers evaluating the effect of dietary change and food reformulation on nutritional and climate change targets. PMID:29659497

Lithium Ion Testing at NSWC Crane in Support of NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Brown, Harry; Jung, David; Lee, Leonine

2010-01-01

This viewgraph presentation reviews Lithium Ion Cell testing at the Naval Surface Warfare Center in Crane, India. The contents include: 1) Quallion 15 Ahr Lithium-Ion Cells, LEO Life Cycle Test; 2) Lithion 50 Ahr Lithium-Ion Cells, LEO Life Cycle Test; 3) ABSL 5 Ahr Lithium-Ion Battery, LRO-LLO Life Cycle Test, SDO-GEO Life Cycle Test; and 4) A123 40 Ahr Lithium-Ion Battery, GPM Life Cycle Test, MMS Life Cycle Test.

Concepts associated with a unified life cycle analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whelan, Gene; Peffers, Melissa S.; Tolle, Duane A.

There is a risk associated with most things in the world, and all things have a life cycle unto themselves, even brownfields. Many components can be described by a''cycle of life.'' For example, five such components are life-form, chemical, process, activity, and idea, although many more may exist. Brownfields may touch upon several of these life cycles. Each life cycle can be represented as independent software; therefore, a software technology structure is being formulated to allow for the seamless linkage of software products, representing various life-cycle aspects. Because classes of these life cycles tend to be independent of each other,more » the current research programs and efforts do not have to be revamped; therefore, this unified life-cycle paradigm builds upon current technology and is backward compatible while embracing future technology. Only when two of these life cycles coincide and one impacts the other is there connectivity and a transfer of information at the interface. The current framework approaches (e.g., FRAMES, 3MRA, etc.) have a design that is amenable to capturing (1) many of these underlying philosophical concepts to assure backward compatibility of diverse independent assessment frameworks and (2) linkage communication to help transfer the needed information at the points of intersection. The key effort will be to identify (1) linkage points (i.e., portals) between life cycles, (2) the type and form of data passing between life cycles, and (3) conditions when life cycles interact and communicate. This paper discusses design aspects associated with a unified life-cycle analysis, which can support not only brownfields but also other types of assessments.« less

NREL: U.S. Life Cycle Inventory Database Home Page

Science.gov Websites

U.S. Life-Cycle Inventory Database Buildings Research Photo of a green field with an ocean in the background. U.S. Life Cycle Inventory Database NREL and its partners created the U.S. Life Cycle Inventory (LCI) Database to help life cycle assessment (LCA) practitioners answer questions about environmental

NREL: U.S. Life Cycle Inventory Database - User Poll

Science.gov Websites

User Poll In preparation for the 2009 U.S. Life Cycle Inventory (LCI) Data Stakeholder meeting, the interested in life cycle analysis. The results from that poll and information gathered from the stakeholders polling data and feedback from life cycle analysis supporters helped develop the U.S. Life Cycle Inventory

Dispersive models describing mosquitoes’ population dynamics

NASA Astrophysics Data System (ADS)

Yamashita, W. M. S.; Takahashi, L. T.; Chapiro, G.

2016-08-01

The global incidences of dengue and, more recently, zica virus have increased the interest in studying and understanding the mosquito population dynamics. Understanding this dynamics is important for public health in countries where climatic and environmental conditions are favorable for the propagation of these diseases. This work is based on the study of nonlinear mathematical models dealing with the life cycle of the dengue mosquito using partial differential equations. We investigate the existence of traveling wave solutions using semi-analytical method combining dynamical systems techniques and numerical integration. Obtained solutions are validated through numerical simulations using finite difference schemes.

10 CFR 436.19 - Life cycle costs.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT... Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the... (d) Energy and/or water costs. [55 FR 48220, Nov. 20, 1990, as amended at 61 FR 32651, June 25, 1996] ...

10 CFR 436.19 - Life cycle costs.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT... Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the... (d) Energy and/or water costs. [55 FR 48220, Nov. 20, 1990, as amended at 61 FR 32651, June 25, 1996] ...

10 CFR 436.19 - Life cycle costs.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Life cycle costs. 436.19 Section 436.19 Energy DEPARTMENT... Procedures for Life Cycle Cost Analyses § 436.19 Life cycle costs. Life cycle costs are the sum of the... (d) Energy and/or water costs. [55 FR 48220, Nov. 20, 1990, as amended at 61 FR 32651, June 25, 1996] ...

Ocean acidification ameliorates harmful effects of warming in primary consumer.

PubMed

Pedersen, Sindre Andre; Hanssen, Anja Elise

2018-01-01

Climate change-induced warming and ocean acidification are considered two imminent threats to marine biodiversity and current ecosystem structures. Here, we have for the first time examined an animal's response to a complete life cycle of exposure to co-occurring warming (+3°C) and ocean acidification (+1,600 μatm CO 2 ), using the key subarctic planktonic copepod, Calanus finmarchicus , as a model species. The animals were generally negatively affected by warming, which significantly reduced the females' energy status and reproductive parameters (respectively, 95% and 69%-87% vs. control). Unexpectedly, simultaneous acidification partially offset the negative effect of warming in an antagonistic manner, significantly improving reproductive parameters and hatching success (233%-340% improvement vs. single warming exposure). The results provide proof of concept that ocean acidification may partially offset negative effects caused by warming in some species. Possible explanations and ecological implications for the observed antagonistic effect are discussed.

10 CFR 435.8 - Life-cycle costing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Life-cycle costing. 435.8 Section 435.8 Energy DEPARTMENT...-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures..., including lower life-cycle costs, positive net savings, savings-to-investment ratio that is estimated to be...

10 CFR 435.8 - Life-cycle costing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Life-cycle costing. 435.8 Section 435.8 Energy DEPARTMENT...-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures..., including lower life-cycle costs, positive net savings, savings-to-investment ratio that is estimated to be...

10 CFR 435.8 - Life-cycle costing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Life-cycle costing. 435.8 Section 435.8 Energy DEPARTMENT...-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures..., including lower life-cycle costs, positive net savings, savings-to-investment ratio that is estimated to be...

In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle

PubMed Central

Lee, Brendan; Yu, Hong; Jahoor, Farook; O'Brien, William; Beaudet, Arthur L.; Reeds, Peter

2000-01-01

Urea cycle disorders are a group of inborn errors of hepatic metabolism that result in often life-threatening hyperammonemia and hyperglutaminemia. Clinical and laboratory diagnosis of partial deficiencies during asymptomatic periods is difficult, and correlation of phenotypic severity with either genotype and/or in vitro enzyme activity is often imprecise. We hypothesized that stable isotopically determined in vivo rates of total body urea synthesis and urea cycle-specific nitrogen flux would correlate with both phenotypic severity and carrier status in patients with a variety of different enzymatic deficiencies of the urea cycle. We studied control subjects, patients, and their relatives with different enzymatic deficiencies affecting the urea cycle while consuming a low protein diet. On a separate occasion the subjects either received a higher protein intake or were treated with an alternative route medication sodium phenylacetate/benzoate (Ucephan), or oral arginine supplementation. Total urea synthesis from all nitrogen sources was determined from [18O]urea labeling, and the utilization of peripheral nitrogen was estimated from the relative isotopic enrichments of [15N]urea and [15N]glutamine during i.v. co-infusions of [5-(amide)15N]glutamine and [18O]urea. The ratio of the isotopic enrichments of 15N-urea/15N-glutamine distinguished normal control subjects (ratio = 0.42 ± 0.06) from urea cycle patients with late (0.17 ± 0.03) and neonatal (0.003 ± 0.007) presentations irrespective of enzymatic deficiency. This index of urea cycle activity also distinguished asymptomatic heterozygous carriers of argininosuccinate synthetase deficiency (0.22 ± 0.03), argininosuccinate lyase deficiency (0.35 ± 0.11), and partial ornithine transcarbamylase deficiency (0.26 ± 0.06) from normal controls. Administration of Ucephan lowered, and arginine increased, urea synthesis to the degree predicted from their respective rates of metabolism. The 15N-urea/15N-glutamine ratio is a sensitive index of in vivo urea cycle activity and correlates with clinical severity. Urea synthesis is altered by alternative route medications and arginine supplementation to the degree that is to be expected from theory. This stable isotope protocol provides a sensitive tool for evaluating the efficacy of therapeutic modalities and acts as an aid to the diagnosis and management of urea cycle patients. PMID:10869432

A comparison of production system life cycle models

NASA Astrophysics Data System (ADS)

Attri, Rajesh; Grover, Sandeep

2012-09-01

Companies today need to keep up with the rapidly changing market conditions to stay competitive. The main issues in this paper are related to a company's market and its competitors. The prediction of market behavior is helpful for a manufacturing enterprise to build efficient production systems. However, these predictions are usually not reliable. A production system is required to adapt to changing markets, but such requirement entails higher cost. Hence, analyzing different life cycle models of the production system is necessary. In this paper, different life cycle models of the production system are compared to evaluate the distinctive features and the limitations of each model. Furthermore, the difference between product life cycle and production life cycle is summarized, and the effect of product life cycle on production life cycle is explained. Finally, a production system life cycle model, along with key activities to be performed in each stage, is proposed specifically for the manufacturing sector.

A life cycle database for parasitic acanthocephalans, cestodes, and nematodes

USGS Publications Warehouse

Benesh, Daniel P.; Lafferty, Kevin D.; Kuris, Armand

2017-01-01

Parasitologists have worked out many complex life cycles over the last ~150 years, yet there have been few efforts to synthesize this information to facilitate comparisons among taxa. Most existing host-parasite databases focus on particular host taxa, do not distinguish final from intermediate hosts, and lack parasite life-history information. We summarized the known life cycles of trophically transmitted parasitic acanthocephalans, cestodes, and nematodes. For 973 parasite species, we gathered information from the literature on the hosts infected at each stage of the parasite life cycle (8510 host-parasite species associations), what parasite stage is in each host, and whether parasites need to infect certain hosts to complete the life cycle. We also collected life-history data for these parasites at each life cycle stage, including 2313 development time measurements and 7660 body size measurements. The result is the most comprehensive data summary available for these parasite taxa. In addition to identifying gaps in our knowledge of parasite life cycles, these data can be used to test hypotheses about life cycle evolution, host specificity, parasite life-history strategies, and the roles of parasites in food webs.

Impact of Life-Cycle Stage and Gender on the Ability to Balance Work and Family Responsibilities.

ERIC Educational Resources Information Center

Higgins, Christopher; And Others

1994-01-01

Examined impact of gender and life-cycle stage on three components of work-family conflict using sample of 3,616 respondents. For men, levels of work-family conflict were moderately lower in each successive life-cycle stage. For women, levels were similar in two early life-cycle stages but were significantly lower in later life-cycle stage.…

Geographic variation and evolution in the life cycle of the witch-hazel leaf gall aphid, Hormaphis hamamelidis.

PubMed

von Dohlen, C D; Gill, D E

1989-02-01

Two divergent life cycles associated with different elevations and latitudes have been documented for the witch-hazel leaf gall aphid, Hormaphis hamamelidis. At low elevation in northern Virginia, the aphid had seven distinct generations alternating between the primary host, witchhazel (Hamamelis virginiana), and a secondary host, river birch (Betula nigra). These findings confirm the original published life cycle description for the same locality. A second, abbreviated life cycle consisting of only three generations restricted to witch-hazel was discovered at high elevation (1000 m) in north central and northwestern Virginia. Aphids of both life cycles were sympatric at a middle elevation site. The life cycles and morphology suggest that the two forms are separate species. Although monoecious life cycles on primary hosts in aphids generally are thought to be ancestral to complex host-alternating ones, it is certainly possible that monoecious cycles are sometimes secondarily derived from complex cycles. By constructing a preliminary phylogeny of the described species in the tribe Hormaphidini, we propose that the abbreviated life cycle is derived from the complex one in the case of these witchhazel gall aphids. Our findings are discussed in the context of current theory regarding the evolutionary stability of complex life cycles.

Molecular insight into systematics, host associations, life cycles and geographic distribution of the nematode family Rhabdiasidae.

PubMed

Tkach, Vasyl V; Kuzmin, Yuriy; Snyder, Scott D

2014-04-01

Rhabdiasidae Railliet, 1915 is a globally distributed group of up to 100 known species of nematodes parasitic in amphibians and reptiles. This work presents the results of a molecular phylogenetic analysis of 36 species of Rhabdiasidae from reptiles and amphibians from six continents. New DNA sequences encompassing partial 18S rDNA, ITS1, 5.8S rDNA, ITS2 and partial 28S rDNA regions of nuclear ribosomal DNA were obtained from 27 species and pre-existing sequences for nine species were incorporated. The broad taxonomic, host and geographical coverage of the specimens allowed us to address long-standing questions in rhabdiasid systematics, evolution, geographic distribution, and patterns of host association. Our analysis demonstrated that rhabdiasids parasitic in snakes are an independent genus sister to the rest of the Rhabdiasidae, a status supported by life cycle data. Based on the combined evidence of molecular phylogeny, morphology and life cycle characteristics, a new genus Serpentirhabdias gen. nov. with the type species Serpentirhabdias elaphe (Sharpilo, 1976) comb. nov. is established. The phylogeny supports the monophyly of Entomelas Travassos, 1930, Pneumonema Johnston, 1916 and the largest genus of the family, Rhabdias Stiles and Hassall, 1905. DNA sequence comparisons demonstrate the presence of more than one species in the previously monotypic Pneumonema from Australian scincid lizards. The distribution of some morphological characters in the genus Rhabdias shows little consistency within the phylogenetic tree topology, in particular the apical structures widely used in rhabdiasid systematics. Our data suggest that some of the characters, while valuable for species differentiation, are not appropriate for differentiation among higher taxa and are of limited phylogenetic utility. Rhabdias is the only genus with a cosmopolitan distribution, but some of the lineages within Rhabdias are distributed on a single continent or a group of adjacent zoogeographical regions. Serpentirhabdias, Entomelas and Pneumonema show rather strict specificity to their host groups. The evolution of the Rhabdiasidae clearly included multiple host switching events among different orders and families of amphibians as well as switching between amphibians and squamatan reptiles. Only a few smaller lineages of Rhabdias demonstrate relatively strict associations with a certain group of hosts. Copyright © 2014 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

32 CFR Appendix to Part 162 - Reporting Procedures

Code of Federal Regulations, 2014 CFR

2014-07-01

... generated. e. Projected Life-Cycle Savings. For each PIF project provide the estimated amount of savings the project is projected to earn over the project's economic life. f. Projected Life-Cycle Cost Avoidance. For... Projected Life-Cycle Savings. e. Total Projected Life-Cycle Cost Avoidance. 3. CSI. Each DoD Component that...

10 CFR 433.8 - Life-cycle costing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Life-cycle costing. 433.8 Section 433.8 Energy DEPARTMENT... HIGH-RISE RESIDENTIAL BUILDINGS § 433.8 Life-cycle costing. Each Federal agency shall determine life... choose to use any of four methods, including lower life-cycle costs, positive net savings, savings-to...

19 CFR 207.27 - Short life cycle products.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 19 Customs Duties 3 2013-04-01 2013-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative dumping...

10 CFR 433.8 - Life-cycle costing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Life-cycle costing. 433.8 Section 433.8 Energy DEPARTMENT... HIGH-RISE RESIDENTIAL BUILDINGS § 433.8 Life-cycle costing. Each Federal agency shall determine life... choose to use any of four methods, including lower life-cycle costs, positive net savings, savings-to...

19 CFR 207.27 - Short life cycle products.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 19 Customs Duties 3 2014-04-01 2014-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative dumping...

10 CFR 433.8 - Life-cycle costing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Life-cycle costing. 433.8 Section 433.8 Energy DEPARTMENT... HIGH-RISE RESIDENTIAL BUILDINGS § 433.8 Life-cycle costing. Each Federal agency shall determine life... choose to use any of four methods, including lower life-cycle costs, positive net savings, savings-to...

19 CFR 207.27 - Short life cycle products.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 19 Customs Duties 3 2012-04-01 2012-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative dumping...

19 CFR 207.27 - Short life cycle products.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative dumping...

19 CFR 207.27 - Short life cycle products.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 19 Customs Duties 3 2011-04-01 2011-04-01 false Short life cycle products. 207.27 Section 207.27... SUBSIDIZED EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.27 Short life... short life cycle merchandise which has been the subject of two or more affirmative dumping...

Does It Have a Life Cycle?

ERIC Educational Resources Information Center

Keeley, Page

2010-01-01

If life continues from generation to generation, then all plants and animals must go through a life cycle, even though it may be different from organism to organism. Is this what students have "learned," or do they have their own private conceptions about life cycles? The formative assessment probe "Does It Have a Life Cycle?" reveals some…

Application of Life Cycle Assessment on Electronic Waste Management: A Review.

PubMed

Xue, Mianqiang; Xu, Zhenming

2017-04-01

Electronic waste is a rich source of both valuable materials and toxic substances. Management of electronic waste is one of the biggest challenges of current worldwide concern. As an effective and prevailing environmental management tool, life cycle assessment can evaluate the environmental performance of electronic waste management activities. Quite a few scientific literatures reporting life cycle assessment of electronic waste management with significant outcomes have been recently published. This paper reviewed the trends, characteristics, research gaps, and challenges of these studies providing detailed information for practitioners involved in electronic waste management. The results showed that life cycle assessment studies were most carried out in Europe, followed by Asia and North America. The research subject of the studies mainly includes monitors, waste printed circuit boards, mobile phones, computers, printers, batteries, toys, dishwashers, and light-emitting diodes. CML was the most widely used life cycle impact assessment method in life cycle assessment studies on electronic waste management, followed by EI99. Furthermore, 40% of the reviewed studies combined with other environmental tools, including life cycle cost, material flow analysis, multi-criteria decision analysis, emergy analysis, and hazard assessment which came to more comprehensive conclusions from different aspects. The research gaps and challenges including uneven distribution of life cycle assessment studies, life cycle impact assessment methods selection, comparison of the results, and uncertainty of the life cycle assessment studies were examined. Although life cycle assessment of electronic waste management facing challenges, their results will play more and more important role in electronic waste management practices.

Application of Life Cycle Assessment on Electronic Waste Management: A Review

NASA Astrophysics Data System (ADS)

Xue, Mianqiang; Xu, Zhenming

2017-04-01

Electronic waste is a rich source of both valuable materials and toxic substances. Management of electronic waste is one of the biggest challenges of current worldwide concern. As an effective and prevailing environmental management tool, life cycle assessment can evaluate the environmental performance of electronic waste management activities. Quite a few scientific literatures reporting life cycle assessment of electronic waste management with significant outcomes have been recently published. This paper reviewed the trends, characteristics, research gaps, and challenges of these studies providing detailed information for practitioners involved in electronic waste management. The results showed that life cycle assessment studies were most carried out in Europe, followed by Asia and North America. The research subject of the studies mainly includes monitors, waste printed circuit boards, mobile phones, computers, printers, batteries, toys, dishwashers, and light-emitting diodes. CML was the most widely used life cycle impact assessment method in life cycle assessment studies on electronic waste management, followed by EI99. Furthermore, 40% of the reviewed studies combined with other environmental tools, including life cycle cost, material flow analysis, multi-criteria decision analysis, emergy analysis, and hazard assessment which came to more comprehensive conclusions from different aspects. The research gaps and challenges including uneven distribution of life cycle assessment studies, life cycle impact assessment methods selection, comparison of the results, and uncertainty of the life cycle assessment studies were examined. Although life cycle assessment of electronic waste management facing challenges, their results will play more and more important role in electronic waste management practices.

Transportation life cycle assessment (LCA) synthesis : life cycle assessment learning module series.

DOT National Transportation Integrated Search

2015-03-12

The Life Cycle Assessment Learning Module Series is a set of narrated, self-advancing slideshows on : various topics related to environmental life cycle assessment (LCA). This research project produced the first 27 of such modules, which : are freely...

Life cycle assessment of the use of alternative fuels in cement kilns: A case study.

PubMed

Georgiopoulou, Martha; Lyberatos, Gerasimos

2018-06-15

The benefits of using alternative fuels (AFs) in the cement industry include reduction of the use of non-renewable fossil fuels and lower emissions of greenhouse gases, since fossil fuels are replaced with materials that would otherwise be degraded or incinerated with corresponding emissions and final residues. Furthermore, the use of alternative fuels maximizes the recovery of energy. Seven different scenaria were developed for the production of 1 ton of clinker in a rotary cement kiln. Each of these scenaria includes the use of alternative fuels such as RDF (Refuse derived fuel), TDF (Tire derived fuel) and BS (Biological sludge) or a mixture of them, in partial replacement of conventional fuels such as coal and pet coke. The purpose of this study is to evaluate the environmental impacts of the use of alternative fuels in relation to conventional fuels in the kiln operation. The Life Cycle Assessment (LCA) methodology is used to quantify the potential environmental impacts in each scenario. The interpretation of the results provides the conclusion that the most environmentally friendly prospect is the scenario based on RDF while the less preferable scenario is the scenario based on BS. Copyright © 2017 Elsevier Ltd. All rights reserved.

Stochastic Technology Choice Model for Consequential Life Cycle Assessment.

PubMed

Kätelhön, Arne; Bardow, André; Suh, Sangwon

2016-12-06

Discussions on Consequential Life Cycle Assessment (CLCA) have relied largely on partial or general equilibrium models. Such models are useful for integrating market effects into CLCA, but also have well-recognized limitations such as the poor granularity of the sectoral definition and the assumption of perfect oversight by all economic agents. Building on the Rectangular-Choice-of-Technology (RCOT) model, this study proposes a new modeling approach for CLCA, the Technology Choice Model (TCM). In this approach, the RCOT model is adapted for its use in CLCA and extended to incorporate parameter uncertainties and suboptimal decisions due to market imperfections and information asymmetry in a stochastic setting. In a case study on rice production, we demonstrate that the proposed approach allows modeling of complex production technology mixes and their expected environmental outcomes under uncertainty, at a high level of detail. Incorporating the effect of production constraints, uncertainty, and suboptimal decisions by economic agents significantly affects technology mixes and associated greenhouse gas (GHG) emissions of the system under study. The case study also shows the model's ability to determine both the average and marginal environmental impacts of a product in response to changes in the quantity of final demand.

Modeling the influence of genetic and environmental variation on the expression of plant life cycles across landscapes.

PubMed

Burghardt, Liana T; Metcalf, C Jessica E; Wilczek, Amity M; Schmitt, Johanna; Donohue, Kathleen

2015-02-01

Organisms develop through multiple life stages that differ in environmental tolerances. The seasonal timing, or phenology, of life-stage transitions determines the environmental conditions to which each life stage is exposed and the length of time required to complete a generation. Both environmental and genetic factors contribute to phenological variation, yet predicting their combined effect on life cycles across a geographic range remains a challenge. We linked submodels of the plasticity of individual life stages to create an integrated model that predicts life-cycle phenology in complex environments. We parameterized the model for Arabidopsis thaliana and simulated life cycles in four locations. We compared multiple "genotypes" by varying two parameters associated with natural genetic variation in phenology: seed dormancy and floral repression. The model predicted variation in life cycles across locations that qualitatively matches observed natural phenology. Seed dormancy had larger effects on life-cycle length than floral repression, and results suggest that a genetic cline in dormancy maintains a life-cycle length of 1 year across the geographic range of this species. By integrating across life stages, this approach demonstrates how genetic variation in one transition can influence subsequent transitions and the geographic distribution of life cycles more generally.

The sheepshead minnow as an in vivo model for endocrine disruption in marine teleosts: a partial life-cycle test with 17alpha-ethynylestradiol.

PubMed

Zillioux, E J; Johnson, I C; Kiparissis, Y; Metcalfe, C D; Wheat, J V; Ward, S G; Liu, H

2001-09-01

The sheepshead minnow (Cyprinodon variegatus Lacépède), an estuarine fish species, was exposed to 17alpha-ethynylestradiol (EE2) at nominal test concentrations of 0.2, 2, 20, 200, 400, 800, 1,600, and 3,200 ng/L. Fish were exposed for up to 59 d, from subadult stages to sexual maturity, under flow-through conditions. The exposure period was followed by an evaluation of reproductive success and survival of progeny. The reproductive success of exposed sheepshead minnows, as determined from data on egg production from two subsequent spawning trials, was reduced in fish exposed to 200 ng/L EE2 and, in one spawning trial, in the 20-ng/L treatment. Hatching success was reduced in the progeny of fish exposed to 200 ng/L EE2, but survival was good among fry that successfully hatched. Histological examination indicated generalized edema, damage to gill epithelia, hepatic toxicity, fibrosis of the testis, and evidence of sex reversal, including testes-ova and spermatagonia-like cells in ovaries. The maximum acceptable toxicant concentration (MATC) for gonadal development in males was within the normal range of EE2 concentrations in sewage treatment plant effluents. The exposure regimen and choice of test organism, combined with histological examination, allowed independent evaluation of ecologically significant acute, reproductive and estrogenic endpoints. Estrogen receptor-mediated effects occurred at concentrations where reproductive effects were measurable under standard reproduction assays. The sheepshead minnow appears to be a sensitive in vivo model for partial life-cycle testing of compounds that have the potential to disrupt the endocrine system as well as reproduction in estuarine and coastal marine fish species.

Purification and partial characterization of PfHRP-II protein of Plasmodium falciparum.

PubMed

Ghimire, Prakash; Samantaray, J C; Mirdha, B R; Patra, A K; Panda, A K

2003-12-01

The human malarial parasite Plasmodium falciparum secretes various intra-and extra-cellular proteins during its asexual life cycle in human RBC. Histidine rich protein-II (HRP-II) is one of the most prominent proteins, found to be secreted by P. falciparum throughout the asexual cycle with the peak during mature schizont stage of the parasite development in human IRBC. The high histidine content (35% of the total amino acids in protein) of this protein suggested the potential to bind divalent metal ions. We have demonstrated by metal chelate chromatography, an extraordinary capacity of HRP-II to bind nickel ions (Ni++) and employed this characteristic to purify the extra-cellular HRP-II protein secreted by P. falciparum from culture supernatant. The identity of the purified protein was verified by the relative molecular weight on SDS-PAGE, by reacting with polyclonal antibodies directed against it using Western blot technique.

LIFE CYCLE DESIGN FRAMEWORK AND DEMONSTRATION PROJECTS PROFILES OF AT&T AND ALLIED SIGNAL

EPA Science Inventory

Life cycle design seeks to minimize the environmental burden associated with a product life cycle from raw materials acquisition through manufacturing, use, and end-of-life management. ife cycle design emphasizes integrating environmental requirements into the earliest phases of ...

Life cycles of dominant mayflies (Ephemeroptera) on a torrent of the high Bolivian Andes

PubMed

Molina, Carlos I; Puliafico, Kenneth P

2016-03-01

The mayflies of the temperate and cold zones have well-synchronized life cycles, distinct cohorts, short emergence and flight periods. In contrast, aquatic insects from the tropical zones are characterized by multivoltine life cycles, “non-discernible cohorts” and extended flight periods throughout the year. This report is the first observation of life cycle patterns made of two species of mayflies on a torrent in the high elevation Bolivian Andes. The samples were taken from four sites and four periods during a hydrological season. The life cycle of each species was examined using size-class frequency analysis and a monthly modal progression model (von Bertalanffy’s model) to infer the life cycle synchrony type. These first observations showed a moderately synchronized univoltine life cycle for Andesiops peruvianus (Ulmer, 1920), whereas Meridialaris tintinnabula Pescador and Peters (1987), had an unsynchronized multivoltine life cycle. These results showed that the generalization of all aquatic insects as unsynchronized multivoltine species in the Andean region may not be entirely accurate since there is still a need to further clarify the life cycle patterns of the wide variety of aquatic insects living in this high elevation tropical environment.

From Centralized Disassembly to Life Cycle Management: Status and Progress of E-waste Treatment System in China

NASA Astrophysics Data System (ADS)

Song, Xiaolong; Yang, Jianxin; Lu, Bin; Yang, Dong

2017-01-01

China is now facing e-waste problems from both growing domestic generation and illegal imports. Many stakeholders are involved in the e-waste treatment system due to the complexity of e-waste life cycle. Beginning with the state of the e-waste treatment industry in China, this paper summarizes the latest progress in e-waste management from such aspects as the new edition of the China RoHS Directive, new Treatment List, new funding subsidy standard, and eco-design pilots. Thus, a conceptual model for life cycle management of e-waste is generalized. The operating procedure is to first identify the life cycle stages of the e-waste and extract the important life cycle information. Then, life cycle tools can be used to conduct a systematic analysis to help decide how to maximize the benefits from a series of life cycle engineering processes. Meanwhile, life cycle thinking is applied to improve the legislation relating to e-waste so as to continuously improve the sustainability of the e-waste treatment system. By providing an integrative framework, the life cycle management of e-waste should help to realize sustainable management of e-waste in developing countries.

Optimizing product life cycle processes in design phase

NASA Astrophysics Data System (ADS)

Faneye, Ola. B.; Anderl, Reiner

2002-02-01

Life cycle concepts do not only serve as basis in assisting product developers understand the dependencies between products and their life cycles, they also help in identifying potential opportunities for improvement in products. Common traditional concepts focus mainly on energy and material flow across life phases, necessitating the availability of metrics derived from a reference product. Knowledge of life cycle processes won from an existing product is directly reused in its redesign. Depending on sales volume nevertheless, the environmental impact before product optimization can be substantial. With modern information technologies today, computer-aided life cycle methodologies can be applied well before product use. On the basis of a virtual prototype, life cycle processes are analyzed and optimized, using simulation techniques. This preventive approach does not only help in minimizing (or even eliminating) environmental burdens caused by product, costs incurred due to changes in real product can also be avoided. The paper highlights the relationship between product and life cycle and presents a computer-based methodology for optimizing the product life cycle during design, as presented by SFB 392: Design for Environment - Methods and Tools at Technical University, Darmstadt.

LCIA framework and cross-cutting issues guidance within the UNEP/SETAC Life Cycle Initiative

EPA Science Inventory

Increasing needs for decision support and advances in scientific knowledge within life cycle assessment (LCA) led to substantial efforts to provide global guidance on environmental life cycle impact assessment (LCIA) indicators under the auspices of the UNEP-SETAC Life Cycle Init...

The Model Life-cycle: Training Module

EPA Pesticide Factsheets

Model Life-Cycle includes identification of problems & the subsequent development, evaluation, & application of the model. Objectives: define ‘model life-cycle’, explore stages of model life-cycle, & strategies for development, evaluation, & applications.

10 CFR 434.607 - Life cycle cost analysis criteria.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life cycle cost analysis criteria. 434.607 Section 434.607... HIGH RISE RESIDENTIAL BUILDINGS Building Energy Compliance Alternative § 434.607 Life cycle cost analysis criteria. 607.1 The following life cycle cost criteria applies to the fuel selection requirements...

77 FR 38766 - Proposed Information Collection; Comment Request; International Client Life-Cycle Multi-Purpose...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... Request; International Client Life-Cycle Multi-Purpose Forms AGENCY: International Trade Administration... aspects of an international organization's life-cycle with CS. CS is mandated by Congress to help U.S... trade events to U.S. organizations. The International Client Life-cycle Multi-Purpose Forms, previously...

10 CFR 435.8 - Life-cycle costing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life-cycle costing. 435.8 Section 435.8 Energy DEPARTMENT... BUILDINGS Mandatory Energy Efficiency Standards for Federal Low-Rise Residential Buildings. § 435.8 Life-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures...

77 FR 38582 - Proposed Information Collection; Comment Request; Domestic Client Life-Cycle Multi-Purpose Forms

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... Request; Domestic Client Life-Cycle Multi-Purpose Forms AGENCY: International Trade Administration. ACTION... life-cycle with CS. CS is mandated by Congress to help U.S. organizations, particularly small and... Client Life-cycle Multi-Purpose Forms, previously titled Export Information Services Order Forms, are...

10 CFR 434.607 - Life cycle cost analysis criteria.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life cycle cost analysis criteria. 434.607 Section 434.607... HIGH RISE RESIDENTIAL BUILDINGS Building Energy Compliance Alternative § 434.607 Life cycle cost analysis criteria. 607.1 The following life cycle cost criteria applies to the fuel selection requirements...

10 CFR 435.8 - Life-cycle costing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life-cycle costing. 435.8 Section 435.8 Energy DEPARTMENT... BUILDINGS Mandatory Energy Efficiency Standards for Federal Low-Rise Residential Buildings. § 435.8 Life-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures...

US Federal LCA Commons Life Cycle Inventory Unit Process Template

EPA Science Inventory

The US Federal LCA Commons Life Cycle Inventory Unit Process Template is a multi-sheet Excel template for life cycle inventory data, metadata and other documentation. The template comes as a package that consistent of three parts: (1) the main template itself for life cycle inven...

76 FR 41525 - Hewlett Packard Global Parts Supply Chain, Global Product Life Cycles Management Unit Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... Parts Supply Chain, Global Product Life Cycles Management Unit Including Teleworkers Reporting to... workers of Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles Management Unit...). Since eligible workers of Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles...

7 CFR 2902.8 - Determining life cycle costs, environmental and health benefits, and performance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Determining life cycle costs, environmental and... DESIGNATING BIOBASED PRODUCTS FOR FEDERAL PROCUREMENT General § 2902.8 Determining life cycle costs, environmental and health benefits, and performance. (a) Providing information on life cycle costs and...

77 FR 50724 - Developing Software Life Cycle Processes for Digital Computer Software Used in Safety Systems of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes for Digital... Software Life Cycle Processes for Digital Computer Software used in Safety Systems of Nuclear Power Plants... clarifications, the enhanced consensus practices for developing software life-cycle processes for digital...

Life cycle replacement by gene introduction under an allee effect in periodical cicadas.

PubMed

Nariai, Yukiko; Hayashi, Saki; Morita, Satoru; Umemura, Yoshitaka; Tainaka, Kei-ichi; Sota, Teiji; Cooley, John R; Yoshimura, Jin

2011-04-06

Periodical cicadas (Magicicada spp.) in the USA are divided into three species groups (-decim, -cassini, -decula) of similar but distinct morphology and behavior. Each group contains at least one species with a 17-year life cycle and one with a 13-year cycle; each species is most closely related to one with the other cycle. One explanation for the apparent polyphyly of 13- and 17-year life cycles is that populations switch between the two cycles. Using a numerical model, we test the general feasibility of life cycle switching by the introduction of alleles for one cycle into populations of the other cycle. Our results suggest that fitness reductions at low population densities of mating individuals (the Allee effect) could play a role in life cycle switching. In our model, if the 13-year cycle is genetically dominant, a 17-year cycle population will switch to a 13-year cycle given the introduction of a few 13-year cycle alleles under a moderate Allee effect. We also show that under a weak Allee effect, different year-classes ("broods") with 17-year life cycles can be generated. Remarkably, the outcomes of our models depend only on the dominance relationships of the cycle alleles, irrespective of any fitness advantages.

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight cells. An update

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1991-01-01

An update of validation test results confirming the breakthrough in LEO cycle life of nickel-hydrogen cells containing 26 percent potassium hydroxide (KOH) electrolyte is presented. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen cells is reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH.

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight cells - An update

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1991-01-01

An update of validation test results confirming the breakthrough in LEO cycle life of nickel-hydrogen cells containing 26 percent potassium hydroxide (KOH) electrolyte is presented. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen cells is reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH.

Gimme shelter--the relative sensitivity of parasitic nematodes with direct and indirect life cycles to climate change.

PubMed

Molnár, Péter K; Dobson, Andrew P; Kutz, Susan J

2013-11-01

Climate change is expected to alter the dynamics of host-parasite systems globally. One key element in developing predictive models for these impacts is the life cycle of the parasite. It is, for example, commonly assumed that parasites with an indirect life cycle would be more sensitive to changing environmental conditions than parasites with a direct life cycle due to the greater chance that at least one of their obligate host species will go extinct. Here, we challenge this notion by contrasting parasitic nematodes with a direct life cycle against those with an indirect life cycle. Specifically, we suggest that behavioral thermoregulation by the intermediate host may buffer the larvae of indirectly transmitted parasites against temperature extremes, and hence climate warming. We term this the 'shelter effect'. Formalizing each life cycle in a comprehensive model reveals a fitness advantage for the direct life cycle over the indirect life cycle at low temperatures, but the shelter effect reverses this advantage at high temperatures. When examined for seasonal environments, the models suggest that climate warming may in some regions create a temporal niche in mid-summer that excludes parasites with a direct life cycle, but allows parasites with an indirect life cycle to persist. These patterns are amplified if parasite larvae are able to manipulate their intermediate host to increase ingestion probability by definite hosts. Furthermore, our results suggest that exploiting the benefits of host sheltering may have aided the evolution of indirect life cycles. Our modeling framework utilizes the Metabolic Theory of Ecology to synthesize the complexities of host behavioral thermoregulation and its impacts on various temperature-dependent parasite life history components in a single measure of fitness, R0 . It allows quantitative predictions of climate change impacts, and is easily generalized to many host-parasite systems. © 2013 John Wiley & Sons Ltd.

A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity.

PubMed

Watt, Ari; Moukambi, Felicien; Banadyga, Logan; Groseth, Allison; Callison, Julie; Herwig, Astrid; Ebihara, Hideki; Feldmann, Heinz; Hoenen, Thomas

2014-09-01

Work with infectious Ebola viruses is restricted to biosafety level 4 (BSL4) laboratories, presenting a significant barrier for studying these viruses. Life cycle modeling systems, including minigenome systems and transcription- and replication-competent virus-like particle (trVLP) systems, allow modeling of the virus life cycle under BSL2 conditions; however, all current systems model only certain aspects of the virus life cycle, rely on plasmid-based viral protein expression, and have been used to model only single infectious cycles. We have developed a novel life cycle modeling system allowing continuous passaging of infectious trVLPs containing a tetracistronic minigenome that encodes a reporter and the viral proteins VP40, VP24, and GP1,2. This system is ideally suited for studying morphogenesis, budding, and entry, in addition to genome replication and transcription. Importantly, the specific infectivity of trVLPs in this system was ∼ 500-fold higher than that in previous systems. Using this system for functional studies of VP24, we showed that, contrary to previous reports, VP24 only very modestly inhibits genome replication and transcription when expressed in a regulated fashion, which we confirmed using infectious Ebola viruses. Interestingly, we also discovered a genome length-dependent effect of VP24 on particle infectivity, which was previously undetected due to the short length of monocistronic minigenomes and which is due at least partially to a previously unknown function of VP24 in RNA packaging. Based on our findings, we propose a model for the function of VP24 that reconciles all currently available data regarding the role of VP24 in nucleocapsid assembly as well as genome replication and transcription. Ebola viruses cause severe hemorrhagic fevers in humans, with no countermeasures currently being available, and must be studied in maximum-containment laboratories. Only a few of these laboratories exist worldwide, limiting our ability to study Ebola viruses and develop countermeasures. Here we report the development of a novel reverse genetics-based system that allows the study of Ebola viruses without maximum-containment laboratories. We used this system to investigate the Ebola virus protein VP24, showing that, contrary to previous reports, it only modestly inhibits virus genome replication and transcription but is important for packaging of genomes into virus particles, which constitutes a previously unknown function of VP24 and a potential antiviral target. We further propose a comprehensive model for the function of VP24 in nucleocapsid assembly. Importantly, on the basis of this approach, it should easily be possible to develop similar experimental systems for other viruses that are currently restricted to maximum-containment laboratories. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

78 FR 44052 - Airworthiness Directives; Sikorsky Aircraft Corporation (Sikorsky) Model Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

... a regulatory distinction; and 4. Will not have a significant economic impact, positive or negative... events (LCF1) and partial low cycle fatigue events (LCF2) as those terms are defined in the... the full and partial low fatigue cycle events and record on the component card or equivalent record...

The Sphinx's Riddle: Life and Career Cycles.

ERIC Educational Resources Information Center

Burack, Elmer H.

1984-01-01

Career cycles should be considered apart from life cycles, even though the two are interrelated. This essay examines five theories about life and career cycles, and offers insights into their limitations and potential uses. (JB)

General phase regularized reconstruction using phase cycling.

PubMed

Ong, Frank; Cheng, Joseph Y; Lustig, Michael

2018-07-01

To develop a general phase regularized image reconstruction method, with applications to partial Fourier imaging, water-fat imaging and flow imaging. The problem of enforcing phase constraints in reconstruction was studied under a regularized inverse problem framework. A general phase regularized reconstruction algorithm was proposed to enable various joint reconstruction of partial Fourier imaging, water-fat imaging and flow imaging, along with parallel imaging (PI) and compressed sensing (CS). Since phase regularized reconstruction is inherently non-convex and sensitive to phase wraps in the initial solution, a reconstruction technique, named phase cycling, was proposed to render the overall algorithm invariant to phase wraps. The proposed method was applied to retrospectively under-sampled in vivo datasets and compared with state of the art reconstruction methods. Phase cycling reconstructions showed reduction of artifacts compared to reconstructions without phase cycling and achieved similar performances as state of the art results in partial Fourier, water-fat and divergence-free regularized flow reconstruction. Joint reconstruction of partial Fourier + water-fat imaging + PI + CS, and partial Fourier + divergence-free regularized flow imaging + PI + CS were demonstrated. The proposed phase cycling reconstruction provides an alternative way to perform phase regularized reconstruction, without the need to perform phase unwrapping. It is robust to the choice of initial solutions and encourages the joint reconstruction of phase imaging applications. Magn Reson Med 80:112-125, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Life Cycle Energy Analysis of Reclaimed Water Reuse Projects in Beijing.

PubMed

Fan, Yupeng; Guo, Erhui; Zhai, Yuanzheng; Chang, Andrew C; Qiao, Qi; Kang, Peng

2018-01-01

  To illustrate the benefits of water reuse project, the process-based life cycle analysis (LCA) could be combined with input-output LCA to evaluate the water reuse project. Energy is the only evaluation parameter used in this study. Life cycle assessment of all energy inputs (LCEA) is completed mainly by the life cycle inventory (LCI), taking into account the full life cycle including the construction, the operation, and the demolition phase of the project. Assessment of benefit from water reuse during the life cycle should focus on wastewater discharge reduction and water-saving benefits. The results of LCEA of Beijing water reuse project built in 2014 in a comprehensive way shows that the benefits obtained from the reclaimed water reuse far exceed the life cycle energy consumption. In this paper, the authors apply the LCEA model to estimate the benefits of reclaimed water reuse projects quantitatively.

10 CFR 436.20 - Net savings.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Life Cycle Cost Analyses § 436.20 Net savings. For a retrofit project, net savings may be found by subtracting life cycle costs based on the proposed project from life cycle costs based on not having it. For a new building design, net savings is the difference between the life cycle costs of an alternative...

10 CFR 436.20 - Net savings.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Life Cycle Cost Analyses § 436.20 Net savings. For a retrofit project, net savings may be found by subtracting life cycle costs based on the proposed project from life cycle costs based on not having it. For a new building design, net savings is the difference between the life cycle costs of an alternative...

10 CFR 436.42 - Evaluation of Life-Cycle Cost Effectiveness.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Evaluation of Life-Cycle Cost Effectiveness. 436.42... PROGRAMS Agency Procurement of Energy Efficient Products § 436.42 Evaluation of Life-Cycle Cost...) ENERGY STAR qualified and FEMP designated products may be assumed to be life-cycle cost-effective. (b) In...

10 CFR 435.306 - Selecting a life cycle effective proposed building design.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Selecting a life cycle effective proposed building design... Residential Buildings § 435.306 Selecting a life cycle effective proposed building design. In selecting... prototype, has the highest Net Savings or lowest total life cycle costs calculated in compliance with...

10 CFR 436.42 - Evaluation of Life-Cycle Cost Effectiveness.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Evaluation of Life-Cycle Cost Effectiveness. 436.42... PROGRAMS Agency Procurement of Energy Efficient Products § 436.42 Evaluation of Life-Cycle Cost...) ENERGY STAR qualified and FEMP designated products may be assumed to be life-cycle cost-effective. (b) In...

10 CFR 436.42 - Evaluation of Life-Cycle Cost Effectiveness.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Evaluation of Life-Cycle Cost Effectiveness. 436.42... PROGRAMS Agency Procurement of Energy Efficient Products § 436.42 Evaluation of Life-Cycle Cost...) ENERGY STAR qualified and FEMP designated products may be assumed to be life-cycle cost-effective. (b) In...

10 CFR 435.306 - Selecting a life cycle effective proposed building design.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Selecting a life cycle effective proposed building design... Residential Buildings § 435.306 Selecting a life cycle effective proposed building design. In selecting... prototype, has the highest Net Savings or lowest total life cycle costs calculated in compliance with...

10 CFR 435.306 - Selecting a life cycle effective proposed building design.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Selecting a life cycle effective proposed building design... Residential Buildings § 435.306 Selecting a life cycle effective proposed building design. In selecting... prototype, has the highest Net Savings or lowest total life cycle costs calculated in compliance with...

10 CFR 436.20 - Net savings.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Life Cycle Cost Analyses § 436.20 Net savings. For a retrofit project, net savings may be found by subtracting life cycle costs based on the proposed project from life cycle costs based on not having it. For a new building design, net savings is the difference between the life cycle costs of an alternative...

10 CFR 433.8 - Life-cycle costing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life-cycle costing. 433.8 Section 433.8 Energy DEPARTMENT... FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH-RISE RESIDENTIAL BUILDINGS § 433.8 Life-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures set out in subpart A...

78 FR 47012 - Developing Software Life Cycle Processes Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes Used in... revised regulatory guide (RG), revision 1 of RG 1.173, ``Developing Software Life Cycle Processes for... Developing a Software Project Life Cycle Process,'' issued 2006, with the clarifications and exceptions as...

10 CFR 433.8 - Life-cycle costing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life-cycle costing. 433.8 Section 433.8 Energy DEPARTMENT... FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH-RISE RESIDENTIAL BUILDINGS § 433.8 Life-cycle costing. Each Federal agency shall determine life-cycle cost-effectiveness by using the procedures set out in subpart A...

DEVELOPMENT OF THE METHOD AND U.S. NORMALIZATION DATABASE FOR LIFE CYCLE IMPACT ASSESSMENT AND SUSTAINABILITY METRICS

EPA Science Inventory

Normalization is an optional step within Life Cycle Impact Assessment (LCIA) that may be used to assist in the interpretation of life cycle inventory data as well as, life cycle impact assessment results. Normalization transforms the magnitude of LCI and LCIA results into relati...

10 CFR 436.42 - Evaluation of Life-Cycle Cost Effectiveness.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Evaluation of Life-Cycle Cost Effectiveness. 436.42... PROGRAMS Agency Procurement of Energy Efficient Products § 436.42 Evaluation of Life-Cycle Cost...) ENERGY STAR qualified and FEMP designated products may be assumed to be life-cycle cost-effective. (b) In...

10 CFR 435.306 - Selecting a life cycle effective proposed building design.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Selecting a life cycle effective proposed building design... Residential Buildings § 435.306 Selecting a life cycle effective proposed building design. In selecting... prototype, has the highest Net Savings or lowest total life cycle costs calculated in compliance with...

Residential Preferences and Moving Behavior: A Family Life Cycle Analysis.

ERIC Educational Resources Information Center

McAuley, William J.; Nutty, Cheri L.

The relationship of family life cycle changes to housing preferences and residential mobility is examined. Two residential decision-making issues are explored in detail--how family life cycle stages influence what people view as important to their choice of residential setting and what individuals at different family life cycle stages view as the…

10 CFR 436.20 - Net savings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Life Cycle Cost Analyses § 436.20 Net savings. For a retrofit project, net savings may be found by subtracting life cycle costs based on the proposed project from life cycle costs based on not having it. For a new building design, net savings is the difference between the life cycle costs of an alternative...

10 CFR 436.20 - Net savings.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Life Cycle Cost Analyses § 436.20 Net savings. For a retrofit project, net savings may be found by subtracting life cycle costs based on the proposed project from life cycle costs based on not having it. For a new building design, net savings is the difference between the life cycle costs of an alternative...

10 CFR 436.42 - Evaluation of Life-Cycle Cost Effectiveness.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the life-cycle cost analysis method in part 436, subpart A, of title 10 of the Code of Federal... 10 Energy 3 2011-01-01 2011-01-01 false Evaluation of Life-Cycle Cost Effectiveness. 436.42... PROGRAMS Agency Procurement of Energy Efficient Products § 436.42 Evaluation of Life-Cycle Cost...

Computer-assisted engineering data base

NASA Technical Reports Server (NTRS)

Dube, R. P.; Johnson, H. R.

1983-01-01

General capabilities of data base management technology are described. Information requirements posed by the space station life cycle are discussed, and it is asserted that data base management technology supporting engineering/manufacturing in a heterogeneous hardware/data base management system environment should be applied to meeting these requirements. Today's commercial systems do not satisfy all of these requirements. The features of an R&D data base management system being developed to investigate data base management in the engineering/manufacturing environment are discussed. Features of this system represent only a partial solution to space station requirements. Areas where this system should be extended to meet full space station information management requirements are discussed.

Mitigation of near-band balanced steady-state free precession through-plane flow artifacts using partial dephasing.

PubMed

Datta, Anjali; Cheng, Joseph Y; Hargreaves, Brian A; Baron, Corey A; Nishimura, Dwight G

2018-06-01

To mitigate artifacts from through-plane flow at the locations of steady-state stopbands in balanced steady-state free precession (SSFP) using partial dephasing. A 60° range in the phase accrual during a TR was created over the voxel by slightly unbalancing the slice-select dephaser. The spectral profiles of SSFP with partial dephasing for various constant flow rates and during pulsatile flow were simulated to determine if partial dephasing decreases through-plane flow artifacts originating near SSFP dark bands while maintaining on-resonant signal. Simulations were then validated in a flow phantom. Lastly, phase-cycled SSFP cardiac cine images were acquired with and without partial dephasing in six subjects. Partial dephasing decreased the strength and non-linearity of the dependence of the signal at the stopbands on the through-plane flow rate. It thus mitigated hyper-enhancement from out-of-slice signal contributions and transient-related artifacts caused by variable flow both in the phantom and in vivo. In six volunteers, partial dephasing noticeably decreased artifacts in all of the phase-cycled cardiac cine datasets. Partial dephasing can mitigate the flow artifacts seen at the stopbands in balanced SSFP while maintaining the sequence's desired signal. By mitigating hyper-enhancement and transient-related artifacts originating from the stopbands, partial dephasing facilitates robust multiple-acquisition phase-cycled SSFP in the heart. Magn Reson Med 79:2944-2953, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

KOH concentration effect on cycle life of nickel-hydrogen cells

NASA Technical Reports Server (NTRS)

Lim, Hong S.; Verzwyvelt, S. A.

1987-01-01

A cycle life test of Ni/H2 cells containing electrolytes of various KOH concentrations and a sintered type nickel electrode was carried out at 23 C using a 45 min accelerated low Earth orbit (LEO) cycle regime at 80 percent depth of discharge. One of three cells containing 26 percent KOH has achieved over 28,000 cycles, and the other two 19,000 cycles, without a sign of failure. Two other cells containing 31 percent KOH electrolyte, which is the concentration presently used in aerospace cells, failed after 2,979 and 3,620 cycles. This result indicates that the cycle life of the present type of Ni/H2 cells may be extended by a factor of 5 to 10 simply by lowering the KOH concentration. Long cycle life of a Ni/H2 battery at high depth-of-discharge operation is desired, particularly for an LEO spacecraft application. Typically, battery life of about 30,000 cycles is required for a five year mission in an LEO. Such a cycle life with presently available cells can be assured only at a very low depth-of-discharge operation. Results of testing already show that the cycle life of an Ni/H2 cell is tremendously improved by simply using an electrolyte of low KOH concentration.

10 CFR 455.64 - Life-cycle cost methodology.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Life-cycle cost methodology. 455.64 Section 455.64 Energy..., Hospitals, Units of Local Government, and Public Care Institutions § 455.64 Life-cycle cost methodology. (a) The life-cycle cost methodology under § 455.63(b) of this part is a systematic comparison of the...

NREL: U.S. Life Cycle Inventory Database - About the LCI Database Project

Science.gov Websites

About the LCI Database Project The U.S. Life Cycle Inventory (LCI) Database is a publicly available data collection and analysis methods. Finding consistent and transparent LCI data for life cycle and maintain the database. The 2009 U.S. Life Cycle Inventory (LCI) Data Stakeholder meeting was an

10 CFR 455.64 - Life-cycle cost methodology.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Life-cycle cost methodology. 455.64 Section 455.64 Energy..., Hospitals, Units of Local Government, and Public Care Institutions § 455.64 Life-cycle cost methodology. (a) The life-cycle cost methodology under § 455.63(b) of this part is a systematic comparison of the...

Alternative Fuels Data Center: Benefits and Considerations of Electricity

Science.gov Websites

tailpipe emissions when in all-electric mode. The life cycle emissions of an EV or PHEV depend on the low-polluting energy sources for electricity production, plug-in vehicles typically have a life cycle strong life cycle emissions benefit. Use the Vehicle Cost Calculator to compare life cycle emissions of

The Early Years: "Life" Science

ERIC Educational Resources Information Center

Ashbrook, Peggy

2013-01-01

Talking about death as part of a life cycle is often ignored or spoken about in hushed tones in early childhood. Books with "life cycle" in the title often do not include the death of the living organism in the information about the cycle. The concept of a complete life cycle does not appear in "A Framework for K-12 Science…

Alberta Carpenter | NREL

Science.gov Websites

cycle assessment in industrial by-product management, waste management, biofuels and manufacturing technologies Life cycle inventory database management Research Interests Life cycle assessment Life cycle inventory management Biofuels Advanced manufacturing Supply chain analysis Education Ph.D in environmental

NREL: U.S. Life Cycle Inventory Database - Publications

Science.gov Websites

Publications Planning Documents U.S. Life Cycle Inventory Database Roadmap, February 2009 U.S. Life Cycle Inventory User Survey, February 2009 U.S. LCI Database Factsheet, March 2005 User's Guide for Life

Autonomy and integration in complex parasite life cycles.

PubMed

Benesh, Daniel P

2016-12-01

Complex life cycles are common in free-living and parasitic organisms alike. The adaptive decoupling hypothesis postulates that separate life cycle stages have a degree of developmental and genetic autonomy, allowing them to be independently optimized for dissimilar, competing tasks. That is, complex life cycles evolved to facilitate functional specialization. Here, I review the connections between the different stages in parasite life cycles. I first examine evolutionary connections between life stages, such as the genetic coupling of parasite performance in consecutive hosts, the interspecific correlations between traits expressed in different hosts, and the developmental and functional obstacles to stage loss. Then, I evaluate how environmental factors link life stages through carryover effects, where stressful larval conditions impact parasites even after transmission to a new host. There is evidence for both autonomy and integration across stages, so the relevant question becomes how integrated are parasite life cycles and through what mechanisms? By highlighting how genetics, development, selection and the environment can lead to interdependencies among successive life stages, I wish to promote a holistic approach to studying complex life cycle parasites and emphasize that what happens in one stage is potentially highly relevant for later stages.

A Comparison of Supercritical Carbon Dioxide Power Cycle Configurations with an Emphasis on CSP Applications (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neises, T.; Turchi, C.

2013-09-01

Recent research suggests that an emerging power cycle technology using supercritical carbon dioxide (s-CO2) operated in a closed-loop Brayton cycle offers the potential of equivalent or higher cycle efficiency versus supercritical or superheated steam cycles at temperatures relevant for CSP applications. Preliminary design-point modeling suggests that s-CO2 cycle configurations can be devised that have similar overall efficiency but different temperature and/or pressure characteristics. This paper employs a more detailed heat exchanger model than previous work to compare the recompression and partial cooling cycles, two cycles with high design-point efficiencies, and illustrates the potential advantages of the latter. Integration of themore » cycles into CSP systems is studied, with a focus on sensible heat thermal storage and direct s-CO2 receivers. Results show the partial cooling cycle may offer a larger temperature difference across the primary heat exchanger, thereby potentially reducing heat exchanger cost and improving CSP receiver efficiency.« less

Interplay between solid Earth and biological evolution

NASA Astrophysics Data System (ADS)

Höning, Dennis; Spohn, Tilman

2017-04-01

Major shifts in Earth's evolution led to progressive adaptations of the biosphere. Particularly the emergence of continents permitted efficient use of solar energy. However, the widespread evolution of the biosphere fed back to the Earth system, often argued as a cause for the great oxidation event or as an important component in stabilizing Earth's climate. Furthermore, biologically enhanced weathering rates alter the flux of sediments in subduction zones, establishing a potential link to the deep interior. Stably bound water within subducting sediments not only enhances partial melting but further affects the mantle rheology. The mantle responds by enhancing its rates of convection, water outgassing, and subduction. How crucial is the emergence and evolution of life on Earth to these processes, and how would Earth have been evolved without the emergence of life? We here discuss concepts and present models addressing these questions and discuss the biosphere as a major component in evolving Earth system feedback cycles.

Potential Antiviral Agents from Marine Fungi: An Overview

PubMed Central

Zorofchian Moghadamtousi, Soheil; Nikzad, Sonia; Abdul Kadir, Habsah; Abubakar, Sazaly; Zandi, Keivan

2015-01-01

Biodiversity of the marine world is only partially subjected to detailed scientific scrutiny in comparison to terrestrial life. Life in the marine world depends heavily on marine fungi scavenging the oceans of lifeless plants and animals and entering them into the nutrient cycle by. Approximately 150 to 200 new compounds, including alkaloids, sesquiterpenes, polyketides, and aromatic compounds, are identified from marine fungi annually. In recent years, numerous investigations demonstrated the tremendous potential of marine fungi as a promising source to develop new antivirals against different important viruses, including herpes simplex viruses, the human immunodeficiency virus, and the influenza virus. Various genera of marine fungi such as Aspergillus, Penicillium, Cladosporium, and Fusarium were subjected to compound isolation and antiviral studies, which led to an illustration of the strong antiviral activity of a variety of marine fungi-derived compounds. The present review strives to summarize all available knowledge on active compounds isolated from marine fungi with antiviral activity. PMID:26204947

Quantification of the Service Life Extension and Environmental Benefit of Chloride Exposed Self-Healing Concrete.

PubMed

Van Belleghem, Bjorn; Van den Heede, Philip; Van Tittelboom, Kim; De Belie, Nele

2016-12-23

Formation of cracks impairs the durability of concrete elements. Corrosion inducing substances, such as chlorides, can enter the matrix through these cracks and cause steel reinforcement corrosion and concrete degradation. Self-repair of concrete cracks is an innovative technique which has been studied extensively during the past decade and which may help to increase the sustainability of concrete. However, the experiments conducted until now did not allow for an assessment of the service life extension possible with self-healing concrete in comparison with traditional (cracked) concrete. In this research, a service life prediction of self-healing concrete was done based on input from chloride diffusion tests. Self-healing of cracks with encapsulated polyurethane precursor formed a partial barrier against immediate ingress of chlorides through the cracks. Application of self-healing concrete was able to reduce the chloride concentration in a cracked zone by 75% or more. As a result, service life of steel reinforced self-healing concrete slabs in marine environments could amount to 60-94 years as opposed to only seven years for ordinary (cracked) concrete. Subsequent life cycle assessment calculations indicated important environmental benefits (56%-75%) for the ten CML-IA (Center of Environmental Science of Leiden University-Impact Assessment) baseline impact indicators which are mainly induced by the achievable service life extension.

10 CFR 436.10 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Cycle Cost Analyses § 436.10 Purpose. This subpart establishes a methodology and procedures for estimating and comparing the life cycle costs of Federal buildings, for determining the life cycle cost effectiveness of energy conservation measures and water conservation measures, and for rank ordering life cycle...

Shortening tobacco life cycle accelerates functional gene identification in genomic research.

PubMed

Ning, G; Xiao, X; Lv, H; Li, X; Zuo, Y; Bao, M

2012-11-01

Definitive allocation of function requires the introduction of genetic mutations and analysis of their phenotypic consequences. Novel, rapid and convenient techniques or materials are very important and useful to accelerate gene identification in functional genomics research. Here, over-expression of PmFT (Prunus mume), a novel FT orthologue, and PtFT (Populus tremula) lead to shortening of the tobacco life cycle. A series of novel short life cycle stable tobacco lines (30-50 days) were developed through repeated self-crossing selection breeding. Based on the second transformation via a gusA reporter gene, the promoter from BpFULL1 in silver birch (Betula pendula) and the gene (CPC) from Arabidopsis thaliana were effectively tested using short life cycle tobacco lines. Comparative analysis among wild type, short life cycle tobacco and Arabidopsis transformation system verified that it is optional to accelerate functional gene studies by shortening host plant material life cycle, at least in these short life cycle tobacco lines. The results verified that the novel short life cycle transgenic tobacco lines not only combine the advantages of economic nursery requirements and a simple transformation system, but also provide a robust, effective and stable host system to accelerate gene analysis. Thus, shortening tobacco life cycle strategy is feasible to accelerate heterologous or homologous functional gene identification in genomic research. © 2012 German Botanical Society and The Royal Botanical Society of the Netherlands.

NREL, Johns Hopkins SAIS Develop Method to Quantify Life Cycle Land Use of

Science.gov Websites

Life Cycle Land Use of Electricity from Natural Gas News Release: NREL, Johns Hopkins SAIS Develop Method to Quantify Life Cycle Land Use of Electricity from Natural Gas October 2, 2017 A case study of time provides quantifiable information on the life cycle land use of generating electricity from

REPORT ON ACTIVITY OF TASK FORCE 1 IN THE LIFE CYCLE INVENTORY PROGRAMME: DATA REGISTRY - GLOBAL LIFE CYCLE INVENTORY DATA RESOURCES

EPA Science Inventory

This paper presents a summary of the findings of a report prepared by Task Force 1 of the UNEP/SETAC Life Cycle Initiative on the available Life Cycle Inventory (LCI) databases around the world. An update of a previous summary prepared in May 2002 by Norris and Notten, the repor...

Understanding future emissions from low-carbon power systems by integration of life-cycle assessment and integrated energy modelling

NASA Astrophysics Data System (ADS)

Pehl, Michaja; Arvesen, Anders; Humpenöder, Florian; Popp, Alexander; Hertwich, Edgar G.; Luderer, Gunnar

2017-12-01

Both fossil-fuel and non-fossil-fuel power technologies induce life-cycle greenhouse gas emissions, mainly due to their embodied energy requirements for construction and operation, and upstream CH4 emissions. Here, we integrate prospective life-cycle assessment with global integrated energy-economy-land-use-climate modelling to explore life-cycle emissions of future low-carbon power supply systems and implications for technology choice. Future per-unit life-cycle emissions differ substantially across technologies. For a climate protection scenario, we project life-cycle emissions from fossil fuel carbon capture and sequestration plants of 78-110 gCO2eq kWh-1, compared with 3.5-12 gCO2eq kWh-1 for nuclear, wind and solar power for 2050. Life-cycle emissions from hydropower and bioenergy are substantial (˜100 gCO2eq kWh-1), but highly uncertain. We find that cumulative emissions attributable to upscaling low-carbon power other than hydropower are small compared with direct sectoral fossil fuel emissions and the total carbon budget. Fully considering life-cycle greenhouse gas emissions has only modest effects on the scale and structure of power production in cost-optimal mitigation scenarios.

Application of life cycle assessment for an evaluation of wastewater treatment and reuse project--case study of Xi'an, China.

PubMed

Zhang, Q H; Wang, X C; Xiong, J Q; Chen, R; Cao, B

2010-03-01

In order to illuminate the benefit of a wastewater treatment and reuse project, a life cycle assessment (LCA) model was proposed by combining the process-based LCA and the input-output based LCA in one framework and using energy consumption as the sole parameter for quantitative evaluation of the project. The life cycle consumption was evaluated mainly by life cycle inventory (LCI) analysis taking into account the construction phase, operation phase and demolishment phase of the project. For evaluating the life cycle benefit of treated water reuse, attention was paid to the decrease of secondary effluent discharge and water saving. As a result of comprehensive LCA analysis of a case project in Xi'an, China, it was understood that the life cycle benefit gained from treated wastewater reuse much surpassed the life cycle energy consumption. The advantage of wastewater treatment and reuse was well shown by LCA analysis using the proposed model. 2009 Elsevier Ltd. All rights reserved.

A case study by life cycle assessment

NASA Astrophysics Data System (ADS)

Li, Shuyun

2017-05-01

This article aims to assess the potential environmental impact of an electrical grinder during its life cycle. The Life Cycle Inventory Analysis was conducted based on the Simplified Life Cycle Assessment (SLCA) Drivers that calculated from the Valuation of Social Cost and Simplified Life Cycle Assessment Model (VSSM). The detailed results for LCI can be found under Appendix II. The Life Cycle Impact Assessment was performed based on Eco-indicator 99 method. The analysis results indicated that the major contributor to the environmental impact as it accounts for over 60% overall SLCA output. In which, 60% of the emission resulted from the logistic required for the maintenance activities. This was measured by conducting the hotspot analysis. After performing sensitivity analysis, it is evidenced that changing fuel type results in significant decrease environmental footprint. The environmental benefit can also be seen from the negative output values of the recycling activities. By conducting Life Cycle Assessment analysis, the potential environmental impact of the electrical grinder was investigated.

THE EFFECT OF SULFUR ON METHANE PARTIAL OXIDATION AND REFORMING PROCESSES FOR LEAN NOX TRAP CATALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parks, II, James E; Ponnusamy, Senthil

2006-01-01

Lean NOx trap catalysis has demonstrated the ability to reduce NOx emissions from lean natural gas reciprocating engines by >90%. The technology operates in a cyclic fashion where NOx is trapped on the catalyst during lean operation and released and reduced to N2 under rich exhaust conditions; the rich cleansing operation of the cycle is referred to as "regeneration" since the catalyst is reactivated for more NOx trapping after NOx purge. Creating the rich exhaust conditions for regeneration can be accomplished by catalytic partial oxidation of methane in the exhaust system. Furthermore, catalytic reforming of partial oxidation exhaust can enablemore » increased quantities of H2 which is an excellent reductant for lean NOx trap regeneration. It is critical to maintain clean and efficient partial oxidation and reforming processes to keep the lean NOx trap functioning properly and to reduce extra fuel consumption from the regeneration process. Although most exhaust constituents do not impede partial oxidation and reforming, some exhaust constituents may negatively affect the catalysts and result in loss of catalytic efficiency. Of particular concern are common catalyst poisons sulfur, zinc, and phosphorous. These poisons form in the exhaust through combustion of fuel and oil, and although they are present at low concentrations, they can accumulate to significant levels over the life of an engine system. In the work presented here, the effects of sulfur on the partial oxidation and reforming catalytic processes were studied to determine any durability limitations on the production of reductants for lean NOx trap catalyst regeneration.« less

The circle of life: A cross-cultural comparison of children's attribution of life-cycle traits.

PubMed

Burdett, Emily R R; Barrett, Justin L

2016-06-01

Do children attribute mortality and other life-cycle traits to all minded beings? The present study examined whether culture influences young children's ability to conceptualize and differentiate human beings from supernatural beings (such as God) in terms of life-cycle traits. Three-to-5-year-old Israeli and British children were questioned whether their mother, a friend, and God would be subject to various life-cycle processes: Birth, death, ageing, existence/longevity, and parentage. Children did not anthropomorphize but differentiated among human and supernatural beings, attributing life-cycle traits to humans, but not to God. Although 3-year-olds differentiated significantly among agents, 5-year-olds attributed correct life-cycle traits more consistently than younger children. The results also indicated some cross-cultural variation in these attributions. Implications for biological conceptual development are discussed. © 2015 The British Psychological Society.

Long life nickel electrodes for a nickel-hydrogen cell: Cycle life tests

NASA Technical Reports Server (NTRS)

Lim, H. S.; Verzwyvelt, S. A.

1985-01-01

In order to develop a long life nickel electrode for a Ni/H2 cell, the cycle life of nickel electrodes was tested in Ni/H2 boiler plate cells. A 19 test cell matrix was made of various nickel electrode designs including three levels each of plaque mechanical strength, median pore size of the plaque, and active material loading. Test cells were cycled to the end of their life (0.5v) in a 45 minute low Earth orbit cycle regime at 80% depth-of-discharge. It is shown that the active material loading level affects the cycle life the most with the optimum loading at 1.6 g/cc void. Mechanical strength does not affect the cycle life noticeably in the bend strength range of 400 to 700 psi. It is found that the best plaque is made of INCO nickel powder type 287 and has median pore size of 13 micron.

Increase Return on Investment of Software Development Life Cycle by Managing the Risk - A Case Study

DTIC Science & Technology

2015-04-01

for increasing the return on investment during the Software Development Life Cycle ( SDLC ) through selected quantitative analyses employing both the...defect rate, return on investment (ROI), software development life cycle ( SDLC ) DE FE N SE A C Q U IS IT IO N UN IVERSITY ALU M N I A SSO C IATIO N R...becomes comfortable due to its intricacies and learning cycle. The same may be said with respect to software development life cycle ( SDLC ) management

LIFE CYCLE ASSESSMENT FOR PC BLEND 2 AIRCRAFT RADOME DEPAINTER

EPA Science Inventory

This report describes the life cycle assessment on a potential replacement solvent blend for aircraft radome depainting at the Oklahoma City Air Logistics Center at Tinker Air Force Base. The life cycle assessment is composed of three separate but interrelated components: life cy...

No Snowball on Habitable Tidally Locked Planets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Checlair, Jade; Abbot, Dorian S.; Menou, Kristen, E-mail: jadecheclair@uchicago.edu

The TRAPPIST-1, Proxima Centauri, and LHS 1140 systems are the most exciting prospects for future follow-up observations of potentially inhabited planets. All of the planets orbit nearby M-stars and are likely tidally locked in 1:1 spin–orbit states, which motivates the consideration of the effects that tidal locking might have on planetary habitability. On Earth, periods of global glaciation (snowballs) may have been essential for habitability and remote signs of life (biosignatures) because they are correlated with increases in the complexity of life and in the atmospheric oxygen concentration. In this paper, we investigate the snowball bifurcation (sudden onset of globalmore » glaciation) on tidally locked planets using both an energy balance model and an intermediate-complexity global climate model. We show that tidally locked planets are unlikely to exhibit a snowball bifurcation as a direct result of the spatial pattern of insolation they receive. Instead, they will smoothly transition from partial to complete ice coverage and back. A major implication of this work is that tidally locked planets with an active carbon cycle should not be found in a snowball state. Moreover, this work implies that tidally locked planets near the outer edge of the habitable zone with low CO{sub 2} outgassing fluxes will equilibrate with a small unglaciated substellar region rather than cycling between warm and snowball states. More work is needed to determine how the lack of a snowball bifurcation might affect the development of life on a tidally locked planet.« less

Paclitaxel (3-hour infusion) followed by carboplatin (24 hours after paclitaxel): a phase II study in advanced non-small cell lung cancer.

PubMed

Roychowdhury, D F; Desai, P; Zhu, Y W

1997-08-01

This phase II study was performed to investigate the efficacy of a 3-hour 225 mg/m2 paclitaxel infusion (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) followed 24 hours later by a 30-minute infusion of carboplatin (dosed to an area under the concentration-time curve of 6) in patients with stage IIIA, IIIB, or IV non-small cell lung cancer. Patients received chemotherapy and were monitored for toxicity, response, quality of life, and survival. Paclitaxel and carboplatin pharmacokinetics were also determined with the first cycle of chemotherapy. Eleven men have been treated to date. Eight were white and three black, with a median age of 65 years. All patients had a performance status of 0 or 1. The regimen was well tolerated, with no deaths or grade 4 toxicities noted. The most common grade 3 toxicity was neutropenia, thrombocytopenia, and parasthesias (observed in <10% of cycles). The overall response rate was 57% (14% complete and 43% partial responses). Quality of life improved in most patients. Physical and emotional well-being improved in 57%, functional well-being in 43%, and social/family well-being in 14% of patients. Pharmacokinetic data are being analyzed by limited sampling technique to predict the paclitaxel area under the concentration-time curve. This unique schedule of paclitaxel and carboplatin is well tolerated and active, and is associated with improvements in various aspects of quality of life.

No Snowball on Habitable Tidally Locked Planets

NASA Astrophysics Data System (ADS)

Checlair, Jade; Menou, Kristen; Abbot, Dorian S.

2017-08-01

The TRAPPIST-1, Proxima Centauri, and LHS 1140 systems are the most exciting prospects for future follow-up observations of potentially inhabited planets. All of the planets orbit nearby M-stars and are likely tidally locked in 1:1 spin–orbit states, which motivates the consideration of the effects that tidal locking might have on planetary habitability. On Earth, periods of global glaciation (snowballs) may have been essential for habitability and remote signs of life (biosignatures) because they are correlated with increases in the complexity of life and in the atmospheric oxygen concentration. In this paper, we investigate the snowball bifurcation (sudden onset of global glaciation) on tidally locked planets using both an energy balance model and an intermediate-complexity global climate model. We show that tidally locked planets are unlikely to exhibit a snowball bifurcation as a direct result of the spatial pattern of insolation they receive. Instead, they will smoothly transition from partial to complete ice coverage and back. A major implication of this work is that tidally locked planets with an active carbon cycle should not be found in a snowball state. Moreover, this work implies that tidally locked planets near the outer edge of the habitable zone with low CO2 outgassing fluxes will equilibrate with a small unglaciated substellar region rather than cycling between warm and snowball states. More work is needed to determine how the lack of a snowball bifurcation might affect the development of life on a tidally locked planet.

Enhanced performance of Zn(II)-doped lead-acid batteries with electrochemical active carbon in negative mass

NASA Astrophysics Data System (ADS)

Xiang, Jiayuan; Hu, Chen; Chen, Liying; Zhang, Dong; Ding, Ping; Chen, Dong; Liu, Hao; Chen, Jian; Wu, Xianzhang; Lai, Xiaokang

2016-10-01

The effect and mechanism of Zn(II) on improving the performances of lead-acid cell with electrochemical active carbon (EAC) in negative mass is investigated. The hydrogen evolution of the cell is significantly reduced due to the deposition of Zn on carbon surface and the increased porosity of negative mass. Zn(II) additives can also improve the low-temperature and high-rate capacities of the cell with EAC in negative mass, which ascribes to the formation of Zn on lead and carbon surface that constructs a conductive bridge among the active mass. Under the co-contribution of EAC and Zn(II), the partial-state-of-charge cycle life is greatly prolonged. EAC optimizes the NAM structure and porosity to enhance the charge acceptance and retard the lead sulfate accumulation. Zn(II) additive reduces the hydrogen evolution during charge process and improves the electric conductivity of the negative electrode. The cell with 0.6 wt% EAC and 0.006 wt% ZnO in negative mass exhibits 90% reversible capacity of the initial capacity after 2100 cycles. In contrast, the cell with 0.6 wt% EAC exhibits 84% reversible capacity after 2100 cycles and the control cell with no EAC and Zn(II) exhibits less than 80% reversible capacity after 1350 cycles.

Spinel FeCo2S4 nanoflower arrays grown on Ni foam as novel binder-free electrodes for long-cycle-life supercapacitors

NASA Astrophysics Data System (ADS)

Deng, Cuifen; Yang, Lishan; Yang, Chunming; Shen, Ping; Zhao, Liping; Wang, Zhiyu; Wang, Chunhui; Li, Junhua; Qian, Dong

2018-01-01

Spinel FeCo2S4 nanoflower arrays grown on Ni foam (FeCo2S4@Ni) have been successfully fabricated via a facile hydrothermal sulfurization of the corresponding FeCo2O4 precursor. The results of X-ray diffraction and X-ray photoelectron spectroscopy characterizations affirm that partial Co2+/Co3+ ions in Co3S4 have been substituted by Fe2+/Fe3+ ions to form FeCo2S4. The obtained FeCo2S4@Ni exhibits an ultrahigh specific capacitance (1644.07 mF cm-2 at 50 mA cm-2) and a supreme cycling stability (∼100% after 10,000 cycles at 50 mA cm-2) as binder-free electrodes for supercapacitors. The cycling stability of the fabricated product is the highest among the documented ternary metallic sulfides so far. The excellent supercapacitive performance of FeCo2S4@Ni emanates from the unique architectures of Fe2Co2S4 nanoflower arrays constituted by ultrathin nanoflakes, three-dimensional porous and conductive Ni foam, and solid skeleton of Ni foam for robust connections to the Fe2Co2S4.

Study of the aging of LaNi 3.55Mn 0.4Al 0.3(Co 1-xFe x) 0.75 (0⩽ x⩽1) compounds in Ni-MH batteries by SEM and magnetic measurements

NASA Astrophysics Data System (ADS)

Ayari, M.; Paul-Boncour, V.; Lamloumi, J.; Percheron-Guégan, A.; Guillot, M.

2005-03-01

The study of LaNi 3.55Mn 0.4Al 0.3(Co 1-xFe x) 0.75 (0⩽ x⩽1) alloys as material for negative electrodes in Ni-MH batteries has shown that the electrochemical cycle life is strongly dependent on the amount of substituted iron. The samples have been characterized before and after 2 to 50 electrochemical cycles by scanning electron microscopy (SEM) and magnetization measurements in order to follow the decrepitation and the decomposition of the alloys. The bulk magnetic properties of the alloy show an evolution from a spin glass behaviour dominated by antiferromagnetic interactions towards a ferromagnetic behaviour as the Fe content increases. After electrochemical cycling, the alloys are partially decomposed into La hydroxide and small metallic and oxidized transition metal particles. A correlation has been established between the loss of electrochemical capacity and the alloy decomposition which reaches 45% after 50 cycles for x=1, whereas it remains limited to 10-15% for x=0 and 0.47. A model combining both SEM and magnetic results has been used to estimate the average thickness of the corrosion layer.

Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion

PubMed Central

Tong, Xuemei; Coulombe, Pierre A.

2006-01-01

Mammalian hair follicles cycle between stages of rapid growth (anagen) and metabolic quiescence (telogen) throughout life. Transition from anagen to telogen involves an intermediate stage, catagen, consisting of a swift, apoptosis-driven involution of the lower half of the follicle. How catagen is coordinated, and spares the progenitor cells needed for anagen re-entry, is poorly understood. Keratin 17 (K17)-null mice develop alopecia in the first week post-birth, correlating with hair shaft fragility and untimely apoptosis in the hair bulb. Here we show that this abnormal apoptosis reflects premature entry into catagen. Of the proapoptotic challenges tested, K17-null skin keratinocytes in primary culture are selectively more sensitive to TNFα. K17 interacts with TNF receptor 1 (TNFR1)-associated death domain protein (TRADD), a death adaptor essential for TNFR1-dependent signal relay, suggesting a functional link between this keratin and TNFα signaling. The activity of NF-κB, a downstream target of TNFα, is increased in K17-null skin. We also find that TNFα is required for a timely anagen–catagen transition in mouse pelage follicles, and that its ablation partially rescues the hair cycling defect of K17-null mice. These findings identify K17 and TNFα as two novel and interdependent regulators of hair cycling. PMID:16702408

Controllable Electrochemical Fabrication of KO2-Decorated Binder-Free Cathodes for Rechargeable Lithium-Oxygen Batteries.

PubMed

Yu, Wei; Wang, Huwei; Qin, Lei; Hu, Junyang; Liu, Liang; Li, Baohua; Zhai, Dengyun; Kang, Feiyu

2018-05-23

Understanding the electrochemical property of superoxides in alkali metal oxygen batteries is critical for the design of a stable oxygen battery with high capacity and long cycle performance. In this work, a KO 2 -decorated binder-free cathode is fabricated by a simple and efficient electrochemical strategy. KO 2 nanoparticles are uniformly coated on the carbon nanotube film (CNT-f) through a controllable discharge process in the K-O 2 battery, and the KO 2 -decorated CNT-f is innovatively introduced into the Li-O 2 battery as the O 2 diffusion electrode. The Li-O 2 battery based on the KO 2 -decorated CNT-f cathode can deliver enhanced discharge capacity, reduced charge overpotential, and more stable cycle performance compared with the battery in the absence of KO 2 . In situ formed KO 2 particles on the surface of CNT-f cathode assist to form Li 2 O 2 nanosheets in the Li-O 2 battery, which contributes to the improvement of discharge capacity and cycle life. Interestingly, the analysis of KO 2 -decorated CNT-f cathodes, after discharge and cycle tests, reveals that the electrochemically synthesized KO 2 seems not a conventional electrocatalyst but a partially dissolvable and decomposable promoter in Li-O 2 batteries.

Discharge of three benzotriazole corrosion inhibitors with municipal wastewater and improvements by membrane bioreactor treatment and ozonation.

PubMed

Weiss, Stefan; Jakobs, Jutta; Reemtsma, Thorsten

2006-12-01

A set of three benzotriazole corrosion inhibitors was analyzed by liquid chromatography-mass spectrometry in wastewaters and in a partially closed water cycle in the Berlin region. Benzotriazole (BTri) and two isomers of tolyltriazole (TTri) were determined in untreated municipal wastewater with mean dissolved concentrations of 12 microg/L (BTri), 2.1 microg/L (4-TTri), and 1.3 microg/L (5-TTri). Removal in conventional activated sludge (CAS) municipal wastewater treatment ranged from 37% for BTri to insignificant removal for 4-TTri. In laboratory batch tests 5-TTri was mineralized completely and 4-TTri was mineralized to only 25%. This different behavior of the three benzotriazoles was confirmed by following the triazoles through a partially closed water cycle, into bank filtrate used for drinking water production, where BTri (0.1 microg/L) and 4-TTri (0.03 microg/ L) but no 5-TTri were detected after a travel time of several months. The environmental half-life appears to increase from 5-TTri over BTri to 4-TTri. Treatment of municipal wastewater by a lab-scale membrane bioreactor (MBR) instead of CAS improved the removal of BTri and 5-TTri but could not avoid their discharge. Almost complete removal was achieved by ozonation of the treatment plant effluent with 1 mg O3/mg DOC.

NREL: U.S. Life Cycle Inventory Database - Related Links

Science.gov Websites

) information, LCA tools, research institutes utilizing LCA, labeling initiatives and organizations , international LCA initiatives, LCA online forums. Life Cycle Inventory Data Ecoinvent: Swiss Centre for Life Institute for Environmental Research and Education): The American Center for Life Cycle Assessment SETAC

Optimal seasonal schedules and the relative dominance of heteromorphic and isomorphic life cycles in macroalgae.

PubMed

Bessho, Kazuhiro; Iwasa, Yoh

2010-11-21

Marine macroalgae (seaweed) show diverse life cycles. Species with a heteromorphic life cycle have a large multicellular algal body in one generation but have a very small body in the second generation of the same year. In contrast, the diploid and haploid life forms of isomorphic species have similar morphology, and these species often have more than two generations in a year. Here, we first study the optimal life cycle schedule of marine macroalgae when daily mortality changes seasonally, and then we discuss the conditions for coexistence and relative dominance of different life cycles. According to the optimal life cycle schedule, heteromorphic species tend to have a generation with a large algal body when mortality is low, and a microscopic-sized generation when mortality is high. In contrast, isomorphic species tend to mature when body size reaches a threshold value that is the same for different generations. We then examine the coexistence of the two life cycles when growth rate decreases with biomass. The model predicts that (1) at high latitudes (i.e., in strongly seasonal environments), heteromorphic species are likely to dominate over isomorphic species, and (2) species with a heteromorphic life cycle should dominate in the supratidal and upper intertidal zones where macroalgae tend to suffer high mortality, and also in the subtidal zone, where mortality is low, whereas isomorphic species are likely to be more successful when mortality is intermediate. These predictions are consistent with the observed distribution patterns of the two life cycles in macroalgae. Copyright © 2010 Elsevier Ltd. All rights reserved.

Quantitative Analysis of Hepatitis C NS5A Viral Protein Dynamics on the ER Surface.

PubMed

Knodel, Markus M; Nägel, Arne; Reiter, Sebastian; Vogel, Andreas; Targett-Adams, Paul; McLauchlan, John; Herrmann, Eva; Wittum, Gabriel

2018-01-08

Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research. To date, spatial resolution has only rarely been analyzed in computational/biophysical descriptions of virus replication dynamics. However, it is widely acknowledged that intracellular spatial dependence is a crucial component of virus life cycles. The hepatitis C virus-encoded NS5A protein is an endoplasmatic reticulum (ER)-anchored viral protein and an essential component of the virus replication machinery. Therefore, we simulate NS5A dynamics on realistic reconstructed, curved ER surfaces by means of surface partial differential equations (sPDE) upon unstructured grids. We match the in silico NS5A diffusion constant such that the NS5A sPDE simulation data reproduce experimental NS5A fluorescence recovery after photobleaching (FRAP) time series data. This parameter estimation yields the NS5A diffusion constant. Such parameters are needed for spatial models of HCV dynamics, which we are developing in parallel but remain qualitative at this stage. Thus, our present study likely provides the first quantitative biophysical description of the movement of a viral component. Our spatio-temporal resolved ansatz paves new ways for understanding intricate spatial-defined processes central to specfic aspects of virus life cycles.

Uncovering the abilities of Agaricus bisporus to degrade plant biomass throughout its life cycle.

PubMed

Patyshakuliyeva, Aleksandrina; Post, Harm; Zhou, Miaomiao; Jurak, Edita; Heck, Albert J R; Hildén, Kristiina S; Kabel, Mirjam A; Mäkelä, Miia R; Altelaar, Maarten A F; de Vries, Ronald P

2015-08-01

The economically important edible basidiomycete mushroom Agaricus bisporus thrives on decaying plant material in forests and grasslands of North America and Europe. It degrades forest litter and contributes to global carbon recycling, depolymerizing (hemi-)cellulose and lignin in plant biomass. Relatively little is known about how A. bisporus grows in the controlled environment in commercial production facilities and utilizes its substrate. Using transcriptomics and proteomics, we showed that changes in plant biomass degradation by A. bisporus occur throughout its life cycle. Ligninolytic genes were only highly expressed during the spawning stage day 16. In contrast, (hemi-)cellulolytic genes were highly expressed at the first flush, whereas low expression was observed at the second flush. The essential role for many highly expressed plant biomass degrading genes was supported by exo-proteome analysis. Our data also support a model of sequential lignocellulose degradation by wood-decaying fungi proposed in previous studies, concluding that lignin is degraded at the initial stage of growth in compost and is not modified after the spawning stage. The observed differences in gene expression involved in (hemi-)cellulose degradation between the first and second flushes could partially explain the reduction in the number of mushrooms during the second flush. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

Hemoglobin consumption by P. falciparum in individual erythrocytes imaged via quantitative phase spectroscopy

NASA Astrophysics Data System (ADS)

Rinehart, Matthew T.; Park, Han Sang; Walzer, Katelyn A.; Chi, Jen-Tsan Ashley; Wax, Adam

2016-04-01

Plasmodium falciparum infection causes structural and biochemical changes in red blood cells (RBCs). To quantify these changes, we apply a novel optical technique, quantitative phase spectroscopy (QPS) to characterize individual red blood cells (RBCs) during the intraerythrocytic life cycle of P. falciparum. QPS captures hyperspectral holograms of individual RBCs to measure spectroscopic changes across the visible wavelength range (475-700 nm), providing complex information, i.e. amplitude and phase, about the light field which has interacted with the cell. The complex field provides complimentary information on hemoglobin content and cell mass, which are both found to dramatically change upon infection by P. falciparum. Hb content progressively decreases with parasite life cycle, with an average 72.2% reduction observed for RBCs infected by schizont-stage P. falciparum compared to uninfected cells. Infection also resulted in a 33.1% reduction in RBC’s optical volume, a measure of the cells’ non-aqueous components. Notably, optical volume is only partially correlated with hemoglobin content, suggesting that changes in other dry mass components such as parasite mass may also be assessed using this technique. The unique ability of QPS to discriminate individual healthy and infected cells using spectroscopic changes indicates that the approach can be used to detect disease.

Quantitative Analysis of Hepatitis C NS5A Viral Protein Dynamics on the ER Surface

PubMed Central

Nägel, Arne; Reiter, Sebastian; Vogel, Andreas; McLauchlan, John; Herrmann, Eva; Wittum, Gabriel

2018-01-01

Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research. To date, spatial resolution has only rarely been analyzed in computational/biophysical descriptions of virus replication dynamics. However, it is widely acknowledged that intracellular spatial dependence is a crucial component of virus life cycles. The hepatitis C virus-encoded NS5A protein is an endoplasmatic reticulum (ER)-anchored viral protein and an essential component of the virus replication machinery. Therefore, we simulate NS5A dynamics on realistic reconstructed, curved ER surfaces by means of surface partial differential equations (sPDE) upon unstructured grids. We match the in silico NS5A diffusion constant such that the NS5A sPDE simulation data reproduce experimental NS5A fluorescence recovery after photobleaching (FRAP) time series data. This parameter estimation yields the NS5A diffusion constant. Such parameters are needed for spatial models of HCV dynamics, which we are developing in parallel but remain qualitative at this stage. Thus, our present study likely provides the first quantitative biophysical description of the movement of a viral component. Our spatio-temporal resolved ansatz paves new ways for understanding intricate spatial-defined processes central to specfic aspects of virus life cycles. PMID:29316722

cloncase: Estimation of sex frequency and effective population size by clonemate resampling in partially clonal organisms.

PubMed

Ali, Sajid; Soubeyrand, Samuel; Gladieux, Pierre; Giraud, Tatiana; Leconte, Marc; Gautier, Angélique; Mboup, Mamadou; Chen, Wanquan; de Vallavieille-Pope, Claude; Enjalbert, Jérôme

2016-07-01

Inferring reproductive and demographic parameters of populations is crucial to our understanding of species ecology and evolutionary potential but can be challenging, especially in partially clonal organisms. Here, we describe a new and accurate method, cloncase, for estimating both the rate of sexual vs. asexual reproduction and the effective population size, based on the frequency of clonemate resampling across generations. Simulations showed that our method provides reliable estimates of sex frequency and effective population size for a wide range of parameters. The cloncase method was applied to Puccinia striiformis f.sp. tritici, a fungal pathogen causing stripe/yellow rust, an important wheat disease. This fungus is highly clonal in Europe but has been suggested to recombine in Asia. Using two temporally spaced samples of P. striiformis f.sp. tritici in China, the estimated sex frequency was 75% (i.e. three-quarter of individuals being sexually derived during the yearly sexual cycle), indicating strong contribution of sexual reproduction to the life cycle of the pathogen in this area. The inferred effective population size of this partially clonal organism (Nc  = 998) was in good agreement with estimates obtained using methods based on temporal variations in allelic frequencies. The cloncase estimator presented herein is the first method allowing accurate inference of both sex frequency and effective population size from population data without knowledge of recombination or mutation rates. cloncase can be applied to population genetic data from any organism with cyclical parthenogenesis and should in particular be very useful for improving our understanding of pest and microbial population biology. © 2016 John Wiley & Sons Ltd.

[Life cycle assessment of energy consumption and greenhouse gas emissions of cellulosic ethanol from corn stover].

PubMed

Tian, Wang; Liao, Cuiping; Li, Li; Zhao, Daiqing

2011-03-01

Life Cycle Assessment (LCA) is the only standardized tool currently used to assess environmental loads of products and processes. The life cycle analysis, as a part of LCA, is a useful and powerful methodology for studying life cycle energy efficiency and life cycle GHG emission. To quantitatively explain the potential of energy saving and greenhouse gas (GHG) emissions reduction of corn stover-based ethanol, we analyzed life cycle energy consumption and GHG emissions of corn stover-based ethanol by the method of life cycle analysis. The processes are dilute acid prehydrolysis and enzymatic hydrolysis. The functional unit was defined as 1 km distance driven by the vehicle. Results indicated: compared with gasoline, the corn stover-based E100 (100% ethanol) and E10 (a blend of 10% ethanol and 90% gasoline by volume) could reduce life cycle fossil energy consumption by 79.63% and 6.25% respectively, as well as GHG emissions by 53.98% and 6.69%; the fossil energy consumed by biomass stage was 68.3% of total fossil energy input, N-fertilizer and diesel were the main factors which contributed 45.78% and 33.26% to biomass stage; electricity production process contributed 42.06% to the net GHG emissions, the improvement of technology might reduce emissions markedly.

KOH concentration effect on the cycle life of nickel-hydrogen cells

NASA Technical Reports Server (NTRS)

Lim, H. S.; Verzwyvelt, S. A.

1985-01-01

Effects of KOH concentration on the cycle life of a sintered-type nickel electrode were studied in a boiler plate nickel-hydrogen cell at 23 C using an accelerated 45-min cycle regime at 80 percent depth of discharge. The cycle life improved greatly as the KOH concentration decreased, although the initial capacity of the cell decreased slightly. The cycle life improved by a factor of two or more when the KOH concentration was reduced from 36 to 31 percent and by a similar factor from reductions of 31 to 26 percent. For many applications, this life improvement may outweigh the initial capacity decrease.

Economic evaluation of ticagrelor for secondary prevention following acute coronary syndromes.

PubMed

Gouveia, Miguel; Borges, Margarida; Trindade, Rosário; Rikner, Klas

2015-01-01

To estimate the cost-effectiveness and cost-utility of ticagrelor in the treatment of patients with acute coronary syndromes (unstable angina or myocardial infarction with or without ST-segment elevation), including patients treated medically and those undergoing percutaneous coronary intervention or coronary artery bypass grafting. A short-term decision tree and a long-term Markov model were used to simulate the evolution of patients' life-cycles. Clinical effectiveness data were collected from the PLATO trial and resource use data were obtained from the Hospital de Santa Marta database, disease-related group legislation and the literature. Ticagrelor provides increases of 0.1276 life years and 0.1106 quality-adjusted life years (QALYs) per patient. From a societal perspective these clinical gains entail an increase in expenditure of €610. Thus the incremental cost per life year saved is €4780 and the incremental cost per QALY is €5517. The simulation results show that ticagrelor reduces events compared to clopidogrel. The costs of ticagrelor are partially offset by lower costs arising from events prevented. The use of ticagrelor in clinical practice is therefore cost-effective compared to generic clopidogrel. Copyright © 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier España. All rights reserved.

Effect of LEO cycling on 125 Ah advanced design IPV nickel-hydrogen flight cells - An update

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1991-01-01

An update of validation test results confirming the breakthrough in LEO cycle life of nickel-hydrogen cells containing 26 percent potassium hydroxide (KOH) electrolyte is presented. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen cells is reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH.

A Recommended New Approach on Motorization Ratio Calculations of Stepper Motors

NASA Technical Reports Server (NTRS)

Nalbandian, Ruben; Blais, Thierry; Horth, Richard

2014-01-01

Stepper motors are widely used on most spacecraft mechanisms requiring repeatable and reliable performance. The unique detent torque characteristics of these type of motors makes them behave differently when subjected to low duty cycle excitations where the applied driving pulses are only energized for a fraction of the pulse duration. This phenomenon is even more pronounced in discrete permanent magnet stepper motors used in the space industry. While the inherent high detent properties of discrete permanent magnets provide desirable unpowered holding performance characteristics, it results in unique behavior especially in low duty cycles. Notably, the running torque reduces quickly to the unpowered holding torque when the duty cycle is reduced. The space industry's accepted methodology of calculating the Motorization Ratio (or Torque Margin) is more applicable to systems where the power is continuously applied to the motor coils like brushless DC motors where the cogging torques are low enough not to affect the linear performance of the motors as a function of applied current. This paper summarizes the theoretical and experimental studies performed on a number of space qualified motors under different pulse rates and duty cycles. It is the intention of this paper to introduce a new approach to calculate the Motorization Ratios for discrete permanent magnet steppers under all full and partial duty cycle regimes. The recommended approach defines two distinct relationships to calculate the Motorization Ratio for 100 percent duty cycle and partial duty cycle, when the motor detent (unpowered holding torque) is the main contributor to holding position. These two computations reflect accurately the stepper motor physical behavior as a function of the command phase (ON versus OFF times of the pulses), pointing out how the torque contributors combine. Important points highlighted under this study are the torque margin computations, in particular for well characterized mechanisms. The rationale at CDR level versus TRR/TRB level will be discussed, aiming at avoiding too much conservatism for units that have extensive test and in flight heritage. A critical topic is related to the magnetic losses and how to sort out such phenomena as a function of the motor type being used. For instance, detent torque is a major contributor that has no reason to evolve during life and is not an uncontrolled torque loss.

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans

PubMed Central

Johnson, Thomas E

2007-01-01

Prior studies have shown that disruption of mitochondrial electron transport chain (ETC) function in the nematode Caenorhabditis elegans can result in life extension. Counter to these findings, many mutations that disrupt ETC function in humans are known to be pathologically life-shortening. In this study, we have undertaken the first formal investigation of the role of partial mitochondrial ETC inhibition and its contribution to the life-extension phenotype of C. elegans. We have developed a novel RNA interference (RNAi) dilution strategy to incrementally reduce the expression level of five genes encoding mitochondrial proteins in C. elegans: atp-3, nuo-2, isp-1, cco-1, and frataxin (frh-1). We observed that each RNAi treatment led to marked alterations in multiple ETC components. Using this dilution technique, we observed a consistent, three-phase lifespan response to increasingly greater inhibition by RNAi: at low levels of inhibition, there was no response, then as inhibition increased, lifespan responded by monotonically lengthening. Finally, at the highest levels of RNAi inhibition, lifespan began to shorten. Indirect measurements of whole-animal oxidative stress showed no correlation with life extension. Instead, larval development, fertility, and adult size all became coordinately affected at the same point at which lifespan began to increase. We show that a specific signal, initiated during the L3/L4 larval stage of development, is sufficient for initiating mitochondrial dysfunction–dependent life extension in C. elegans. This stage of development is characterized by the last somatic cell divisions normally undertaken by C. elegans and also by massive mitochondrial DNA expansion. The coordinate effects of mitochondrial dysfunction on several cell cycle–dependent phenotypes, coupled with recent findings directly linking cell cycle progression with mitochondrial activity in C. elegans, lead us to propose that cell cycle checkpoint control plays a key role in specifying longevity of mitochondrial mutants. PMID:17914900

Evaluation of life-cycle air emission factors of freight transportation.

PubMed

Facanha, Cristiano; Horvath, Arpad

2007-10-15

Life-cycle air emission factors associated with road, rail, and air transportation of freight in the United States are analyzed. All life-cycle phases of vehicles, infrastructure, and fuels are accounted for in a hybrid life-cycle assessment (LCA). It includes not only fuel combustion, but also emissions from vehicle manufacturing, maintenance, and end of life, infrastructure construction, operation, maintenance, and end of life, and petroleum exploration, refining, and fuel distribution. Results indicate that total life-cycle emissions of freight transportation modes are underestimated if only tailpipe emissions are accounted for. In the case of CO2 and NOx, tailpipe emissions underestimate total emissions by up to 38%, depending on the mode. Total life-cycle emissions of CO and SO2 are up to seven times higher than tailpipe emissions. Sensitivity analysis considers the effects of vehicle type, geography, and mode efficiency on the final results. Policy implications of this analysis are also discussed. For example, while it is widely assumed that currently proposed regulations will result in substantial reductions in emissions, we find that this is true for NOx, emissions, because fuel combustion is the main cause, and to a lesser extent for SO2, but not for PM10 emissions, which are significantly affected by the other life-cycle phases.

Comparative Life Cycle Assessment between Warm SMA and Conventional SMA

DOT National Transportation Integrated Search

2011-09-01

This report presents the comparative life cycle assessment (LCA) between warm stone mastic asphalt (SMA) and conventional : SMA. Specifically, the study evaluated and compared the life cycle environmental and economic performances of two mixtures: a ...

Geothermal Water Use: Life Cycle Water Consumption, Water Resource Assessment, and Water Policy Framework

DOE Data Explorer

Schroeder, Jenna N.

2014-06-10

This report examines life cycle water consumption for various geothermal technologies to better understand factors that affect water consumption across the life cycle (e.g., power plant cooling, belowground fluid losses) and to assess the potential water challenges that future geothermal power generation projects may face. Previous reports in this series quantified the life cycle freshwater requirements of geothermal power-generating systems, explored operational and environmental concerns related to the geochemical composition of geothermal fluids, and assessed future water demand by geothermal power plants according to growth projections for the industry. This report seeks to extend those analyses by including EGS flash, both as part of the life cycle analysis and water resource assessment. A regional water resource assessment based upon the life cycle results is also presented. Finally, the legal framework of water with respect to geothermal resources in the states with active geothermal development is also analyzed.

Long Life Nickel Electrodes for a Nickel-hydrogen Cell: Cycle Life Tests

NASA Technical Reports Server (NTRS)

Lim, H. S.; Verzwyvelt, S. A.

1984-01-01

In order to develop a long life nickel electrode for a Ni/H2 cell, cycle life tests of nickel electrodes were carried out in Hi/H2 boiler plate cells. A 19 test cell matrix was made of various nickel electrode designs including three levels each of plaque mechanical strength, median pore size of the plaque, and active material loading. Test cells were cycled to the end of their life (0.5v) in a 45-minute low earth orbit cycle regime at 80% depth-of-discharge. The results show that the active material loading level affects the cycle life the most with the optimum loading at 1.6 g/cc void. Mechanical strength did not affect the cycle life noticeably in the bend strength range of 400 to 700 psi. The best plaque type appears to be one which is made of INCO nickel powder type 287 and has a median pore size of 13 micron.

Fitness and Individuality in Complex Life Cycles.

PubMed

Herron, Matthew D

2016-12-01

Complex life cycles are common in the eukaryotic world, and they complicate the question of how to define individuality. Using a bottom-up, gene-centric approach, I consider the concept of fitness in the context of complex life cycles. I analyze the fitness effects of an allele (or a trait) on different biological units within a complex life history and how these effects drive evolutionary change within populations. Based on these effects, I attempt to construct a concept of fitness that accurately predicts evolutionary change in the context of complex life cycles.

Avian tick paralysis caused by Ixodes brunneus in the southeastern United States

USGS Publications Warehouse

Luttrell, M.P.; Creekmore, L.H.; Mertins, J.W.

1996-01-01

Between 1988 and 1994, 16 definitive and 26 presumptive cases of tick paralysis were diagnosed in 10 species of birds from five southeastern states in the USA. All birds had engorged adult female Ixodes brunneus ticks on the head region and were partially paralyzed or dead. Cases occurred in the winter and early spring months, and most birds were passerines found in private yards or near feeders. All stages of I. brunneus feed exclusively on birds, and this species previously has been associated with avian tick paralysis. Little is known concerning the life cycle of this ixodid tick and its impact on wild bird populations.

Taxonomic position of Hormaphis similibetulae Qiao & Zhang, 2004 (Hemiptera, Aphididae): molecular and biological evidences

PubMed Central

Chen, Jing; Jiang, Li-Yun; Qiao, Ge-Xia

2011-01-01

Abstract The taxonomic position of Hormaphis similibetulae Qiao & Zhang, 2004 has been reexamined. The phylogenetic position of Hormaphis similibetulae was inferred by maximum parsimony, maximum likelihood and Bayesian analyses on the basis of partial nuclear elongation factor-1α and mitochondrial tRNA leucine/cytochrome oxidase II sequences. The results showed that this species fell into the clade of Hamamelistes species, occupying a basal position, and was clearly distinct from other Hormaphis species. A closer relationship between Hormaphis similibetulae and Hamamelistes species was also revealed by life cycle analysis. Therefore, we conclude that Hormaphis similibetulae should be transferred to the genus Hamamelistes as Hamamelistes similibetulae (Qiao & Zhang), comb. n. PMID:21852935

A comparative study of commercial lithium ion battery cycle life in electric vehicle: Capacity loss estimation

NASA Astrophysics Data System (ADS)

Han, Xuebing; Ouyang, Minggao; Lu, Languang; Li, Jianqiu

2014-12-01

Now the lithium ion batteries are widely used in electric vehicles (EV). The cycle life is among the most important characteristics of the power battery in EV. In this report, the battery cycle life experiment is designed according to the actual working condition in EV. Five different commercial lithium ion cells are cycled alternatively under 45 °C and 5 °C and the test results are compared. Based on the cycle life experiment results and the identified battery aging mechanism, the battery cycle life models are built and fitted by the genetic algorithm. The capacity loss follows a power law relation with the cycle times and an Arrhenius law relation with the temperature. For automotive application, to save the cost and the testing time, a battery SOH (state of health) estimation method combined the on-line model based capacity estimation and regular calibration is proposed.

A Growth Model for Academic Program Life Cycle (APLC): A Theoretical and Empirical Analysis

ERIC Educational Resources Information Center

Acquah, Edward H. K.

2010-01-01

Academic program life cycle concept states each program's life flows through several stages: introduction, growth, maturity, and decline. A mixed-influence diffusion growth model is fitted to enrolment data on academic programs to analyze the factors determining progress of academic programs through their life cycles. The regression analysis yield…

Physical activity as a mediator of the impact of chronic conditions on quality of life in older adults.

PubMed

Sawatzky, Richard; Liu-Ambrose, Teresa; Miller, William C; Marra, Carlo A

2007-12-19

Chronic conditions could negatively affect the quality of life of older adults. This may be partially due to a relative lack of physical activity. We examined whether physical activity mediates the relationship between different chronic conditions and several health outcomes that are important to the quality of life of older adults. The data were taken from the Canadian Community Health Survey (cycle 1.1), a cross-section survey completed in 2001. Only respondents who were 65 years or older were included in our study (N = 22,432). The Health Utilities Index Mark 3 (HUI3) was used to measure overall quality of life, and to measure selected health outcomes (dexterity, mobility, pain, cognition, and emotional wellbeing) that are considered to be of importance to the quality of life of older adults. Leisure-time physical activity was assessed by determining weekly energy expenditure (Kcal per week) based on the metabolic equivalents of self-reported leisure activities. Linear and logistic regression models were used to determine the mediating effect of leisure-time physical activity while controlling for demographic variables (age and sex), substance use (tobacco use and alcohol consumption), and obesity. Having a chronic condition was associated with a relative decrease in health utility scores and a relative increase in mobility limitations, dexterity problems, pain, emotional problems (i.e., decreased happiness), and cognitive limitations. These negative consequences could be partially attributed to a relative lack of physical activity in older adults with a chronic condition (14% mediation for the HUI3 score). The corresponding degree of mediation was 18% for mobility limitations, 5% for pain, and 13% for emotional wellbeing (statistically significant mediation was not observed for the other health attributes). These values varied with respect to the different chronic conditions examined in our study. Older adults with chronic conditions are less likely to engage in leisure-time physical activities of at least 1,000 Kcal per week, and this association partially accounts for some negative consequences of chronic conditions, including mobility limitations, pain, and emotional problems. These findings provide support for health promotion programs that facilitate or encourage increased leisure-time physical activity in older people with chronic conditions.

A Life Cycle Cost Analysis of Rigid Pavements

DOT National Transportation Integrated Search

1999-09-01

The Texas Department of Transportation (TxDOT)commissioned a research project in 1996, summarized here, to promote life cycle cost analysis of rigid pavements throughout the TxDOT districts by developing a uniform methodology for performing life cycl...

Intersection life cycle cost comparison tool user guide version 1.0.

DOT National Transportation Integrated Search

2016-05-01

The Intersection Life Cycle Cost Comparison Tool User Guide was developed as part of North : Carolina Department of Transportation Research Project No. 201411: Evaluation of Life Cycle : Impacts of Intersection Control Type Selection. : This sprea...

Life Cycle Impact Assessment Research Developments and Needs

EPA Science Inventory

Life Cycle Impact Assessment (LCIA) developments are explained along with key publications which record discussions which comprised ISO 14042 and SETAC document development, UNEP SETAC Life Cycle Initiative research, and research from public and private research institutions. It ...

Hierarchical Tubular Structures Composed of Co3 O4 Hollow Nanoparticles and Carbon Nanotubes for Lithium Storage.

PubMed

Chen, Yu Ming; Yu, Le; Lou, Xiong Wen David

2016-05-10

Hierarchical tubular structures composed of Co3 O4 hollow nanoparticles and carbon nanotubes (CNTs) have been synthesized by an efficient multi-step route. Starting from polymer-cobalt acetate (Co(Ac)2 ) composite nanofibers, uniform polymer-Co(Ac)2 @zeolitic imidazolate framework-67 (ZIF-67) core-shell nanofibers are first synthesized via partial phase transformation with 2-methylimidazole in ethanol. After the selective dissolution of polymer-Co(Ac)2 cores, the resulting ZIF-67 tubular structures can be converted into hierarchical CNTs/Co-carbon hybrids by annealing in Ar/H2 atmosphere. Finally, the hierarchical CNT/Co3 O4 microtubes are obtained by a subsequent thermal treatment in air. Impressively, the as-prepared nanocomposite delivers a high reversible capacity of 1281 mAh g(-1) at 0.1 A g(-1) with exceptional rate capability and long cycle life over 200 cycles as an anode material for lithium-ion batteries. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Application of Pharmacokinetics and Pharmacodynamics in Product Life Cycle Management. A Case Study with a Carbidopa-Levodopa Extended-Release Formulation.

PubMed

Modi, Nishit B

2017-05-01

Increasing costs in discovering and developing new molecular entities and the continuing debate on limited company pipelines mean that pharmaceutical companies are under significant pressure to maximize the value of approved products. Life cycle management in the context of drug development comprises activities to maximize the effective life of a product. Life cycle approaches can involve new formulations, new routes of delivery, new indications or expansion of the population for whom the product is indicated, or development of combination products. Life cycle management may provide an opportunity to improve upon the current product through enhanced efficacy or reduced side effects and could expand the therapeutic market for the product. Successful life cycle management may include the potential for superior efficacy, improved tolerability, or a better prescriber or patient acceptance. Unlike generic products where bioequivalence to an innovator product may be sufficient for drug approval, life cycle management typically requires a series of studies to characterize the value of the product. This review summarizes key considerations in identifying product candidates that may be suitable for life cycle management and discusses the application of pharmacokinetics and pharmacodynamics in developing new products using a life cycle management approach. Examples and a case study to illustrate how pharmacokinetics and pharmacodynamics contributed to the selection of dosing regimens, demonstration of an improved therapeutic effect, or regulatory approval of an improved product label are presented.

Building Maintenance and Repair Data for Life-Cycle Cost Analyses: Electrical Systems.

DTIC Science & Technology

1991-05-01

Repair Data for Life-Cycle Cost Analyses: Electrical Systems by Edgar S. Neely Robert D. Neathammer James R. Stirn Robert P. Winkler This research...systems have been developed to assist planners in preparing DD Form 1391 documentation, designers in life-cycle cost component selection, and maintainers...Maintenance and Repair Data for Life-Cycle Cost Analyses: RDTE dated 1980 Electrical Systems REIMB 1984 - 1989 6. AUTH4OR(S) Edgar S. Neely, Robert D

Why Army Program Managers Struggle As Life Cycle Managers: A Study of the PM’s Roles, Responsibilities, and Barriers In the Execution of Operations and Support

DTIC Science & Technology

2016-09-01

Support Strategies (PBPSS), throughout the system life cycle .  Maximizing competition, to include small business participation.  Developing...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA JOINT APPLIED PROJECT WHY ARMY PROGRAM MANAGERS STRUGGLE AS LIFE CYCLE MANAGERS...SUBTITLE WHY ARMY PROGRAM MANAGERS STRUGGLE AS LIFE CYCLE MANAGERS: A STUDY OF THE PM’S ROLES, RESPONSIBILITIES, AND BARRIERS IN THE EXECUTION OF

Evolutionary lability of a complex life cycle in the aphid genus Brachycaudus.

PubMed

Emmanuelle, Jousselin; Gwenaelle, Genson; Armelle, Coeur d'acier

2010-09-28

Most aphid species complete their life cycle on the same set of host-plant species, but some (heteroecious species) alternate between different hosts, migrating from primary (woody) to secondary (herbaceous) host plants. The evolutionary processes behind the evolution of this complex life cycle have often been debated. One widely accepted scenario is that heteroecy evolved from monoecy on woody host plants. Several shifts towards monoecy on herbaceous plants have subsequently occurred and resulted in the radiation of aphids. Host alternation would have persisted in some cases due to developmental constraints preventing aphids from shifting their entire life cycle to herbaceous hosts (which are thought to be more favourable). According to this scenario, if aphids lose their primary host during evolution they should not regain it. The genus Brachycaudus includes species with all the types of life cycle (monoecy on woody plants, heteroecy, monoecy on herbs). We used this genus to test hypotheses concerning the evolution of life cycles in aphids. Phylogenetic investigation and character reconstruction suggest that life cycle is evolutionary labile in the genus. Though ancestral character states can be ambiguous depending on optimization methods, all analyses suggest that transitions from monoecy on herbs towards heteroecy have occurred several times. Transitions from heteroecy towards monoecy, are also likely. There have been many shifts in feeding behaviour but we found no significant correlation between life cycle changes and changes in diet. The transitions from monoecy on herbs towards heteroecy observed in this study go against a widely accepted evolutionary scenario: aphids in the genus Brachycaudus seem to be able to recapture their supposedly ancestral woody host. This suggests that the determinants of host alternation are probably not as complicated as previously thought. Definitive proofs of the lability of life cycle in Brachycaudus will necessitate investigation of these determinants. Life cycle changes, whether corresponding to the loss or acquisition of a primary host, necessarily promote speciation, by inducing shifts of the reproductive phase on different plants. We suggest that the evolutionary lability of life cycle may have driven speciation events in the Brachycaudus genus.

5 CFR 930.301 - Information systems security awareness training program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... training in system/application life cycle management, risk management, and contingency planning. (4) Chief... security management, system/application life cycle management, risk management, and contingency planning... management; and management and implementation level training in system/application life cycle management...

Life Cycle Assessment for Biofuels

EPA Science Inventory

A presentation based on life cycle assessment (LCA) for biofuels is given. The presentation focuses on energy and biofuels, interesting environmental aspects of biofuels, and how to do a life cycle assessment with some examples related to biofuel systems. The stages of a (biofuel...

Data Base Development of Automobile and Light Truck Maintenance : Volume II. Appendix E.

DOT National Transportation Integrated Search

1978-08-01

The document contains the scheduled maintenance data sheets and total cost summaries--both scheduled and unscheduled maintenance (Life cycle cost for Dealers, life cycle cost for Service Stations, life cycle cost for Independent Repair, and scheduled...

Data Base Development of Automobile and Light Truck Maintenance : Volume III. Appendix F.

DOT National Transportation Integrated Search

1978-08-01

The document contains the scheduled maintenance data sheets and total cost summaries--both scheduled and unscheduled maintenance (Life cycle cost for Dealers, life cycle cost for Service Stations, life cycle cost for Independent Repair, and scheduled...

LIFE CYCLE ASSESSMENT: PRINCIPLES AND PRACTICE

EPA Science Inventory

The following document provides an introductory overview of Life Cycle Assessment (LCA) and describes the general uses and major components of LCA. This document is an update and merger of two previous EPA documents on LCA ("Life Cycle Assessment: Inventory Guidelines and Princip...

Highly efficient 6-stroke engine cycle with water injection

DOEpatents

Szybist, James P; Conklin, James C

2012-10-23

A six-stroke engine cycle having improved efficiency. Heat is recovered from the engine combustion gases by using a 6-stroke engine cycle in which combustion gases are partially vented proximate the bottom-dead-center position of the fourth stroke cycle, and water is injected proximate the top-dead-center position of the fourth stroke cycle.

Developing a dynamic life cycle greenhouse gas emission inventory for wood construction for two different end-of-life scenarios

Treesearch

Richard D. Bergman; James Salazar; Scott Bowe

2012-01-01

Static life cycle assessment does not fully describe the carbon footprint of construction wood because of carbon changes in the forest and product pools over time. This study developed a dynamic greenhouse gas (GHG) inventory approach using US Forest Service and life-cycle data to estimate GHG emissions on construction wood for two different end-of-life scenarios....

Targeting radioimmunotherapy of hepatocellular carcinoma with iodine ({sup 131}I) metuximab injection: Clinical Phase I/II trials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen Zhinan; Mi Li; Xu Jing

2006-06-01

Purpose: HAb18G/CD147 is a hepatocellular carcinoma (HCC)-associated antigen. We developed iodine ({sup 131}I) metuximab injection (Licartin), a novel {sup 131}I-labeled HAb18G/CD147-specific monoclonal antibody F(ab'){sub 2} fragment, and evaluated its safety, pharmacokinetics, and clinical efficacy on HCC in Phase I/II trials. Methods and Materials: In a Phase I trial, 28 patients were randomly assigned to receive the injection in 9.25-, 18.5-, 27.75-, or 37-MBq/kg doses by hepatic artery infusion. In a multicenter Phase II trial, 106 patients received the injection (27.75 MBq/kg) on Day 1 of a 28-day cycle. Response rate and survival rate were the endpoints. Results: No life-threatening toxicmore » effects were found. The safe dosage was 27.75 MBq/kg. The blood clearance fitted a biphasic model, and its half-life was 90.56-63.93 h. In the Phase II trial, the injection was found to be targeted and concentrated to tumor tissues. Of the 73 patients completing two cycles, 6 (8.22%) had a partial response, 14 (19.18%) minor response, and 43 (58.90%) stable disease. The 21-month survival rate was 44.54%. The survival rate of progression-free patients was significantly higher than that of patients with progressive disease after either one or two cycles (p < 0.0001 or p 0.0019). Conclusion: Iodine ({sup 131}I) metuximab injection is safe and active for HCC patients.« less

A Methodology for Integrated, Multiregional Life Cycle Assessment Scenarios under Large-Scale Technological Change.

PubMed

Gibon, Thomas; Wood, Richard; Arvesen, Anders; Bergesen, Joseph D; Suh, Sangwon; Hertwich, Edgar G

2015-09-15

Climate change mitigation demands large-scale technological change on a global level and, if successfully implemented, will significantly affect how products and services are produced and consumed. In order to anticipate the life cycle environmental impacts of products under climate mitigation scenarios, we present the modeling framework of an integrated hybrid life cycle assessment model covering nine world regions. Life cycle assessment databases and multiregional input-output tables are adapted using forecasted changes in technology and resources up to 2050 under a 2 °C scenario. We call the result of this modeling "technology hybridized environmental-economic model with integrated scenarios" (THEMIS). As a case study, we apply THEMIS in an integrated environmental assessment of concentrating solar power. Life-cycle greenhouse gas emissions for this plant range from 33 to 95 g CO2 eq./kWh across different world regions in 2010, falling to 30-87 g CO2 eq./kWh in 2050. Using regional life cycle data yields insightful results. More generally, these results also highlight the need for systematic life cycle frameworks that capture the actual consequences and feedback effects of large-scale policies in the long term.

THE COMPONENTS OF KIN COMPETITION

PubMed Central

Van Dyken, J. David

2011-01-01

It is well known that competition among kin alters the rate and often the direction of evolution in subdivided populations. Yet much remains unclear about the ecological and demographic causes of kin competition, or what role life cycle plays in promoting or ameliorating its effects. Using the multilevel Price equation, I derive a general equation for evolution in structured populations under an arbitrary intensity of kin competition. This equation partitions the effects of selection and demography, and recovers numerous previous models as special cases. I quantify the degree of kin competition, α, which explicitly depends on life cycle. I show how life cycle and demographic assumptions can be incorporated into kin selection models via α, revealing life cycles that are more or less permissive of altruism. As an example, I give closed-form results for Hamilton’s rule in a three-stage life cycle. Although results are sensitive to life cycle in general, I identify three demographic conditions that give life cycle invariant results. Under the infinite island model, α is a function of the scale of density regulation and dispersal rate, effectively disentangling these two phenomena. Population viscosity per se does not impede kin selection. PMID:20482610

[Specific manifestations of polyvariant life cycles in ground beetles (Coleoptera, Carabidae) along latitudinal gradient].

PubMed

Matalin, A V

2014-01-01

The life cycles of Carabidae are highly diverse, and 25 variants of these cycles are realized In the European part of Russia, from semideserts to continental tundras. The diversity of the life cycle spectrum sharply decreases (by more than half) upon transition from nemoral to boreal forest communities, and its phenological unification takes place at high latitudes. The greatest proportion of species with polyvariant development (25%) is characteristic of temporal latitudes, which may be explained by relatively long growing season and considerable cenotic diversity. In both southern (semidesert and steppe) and northern regions (middle and northern boreal forests), this proportion does not exceed 5%. At low latitudes, the polyvariant pattern of development is often manifested in the form of facultative bivoltine life cycles or as facultative biennial life cycles in species with the initial "spring" breeding type.

Clock genes and their genomic distributions in three species of salmonid fishes: Associations with genes regulating sexual maturation and cell cycling

PubMed Central

2010-01-01

Background Clock family genes encode transcription factors that regulate clock-controlled genes and thus regulate many physiological mechanisms/processes in a circadian fashion. Clock1 duplicates and copies of Clock3 and NPAS2-like genes were partially characterized (genomic sequencing) and mapped using family-based indels/SNPs in rainbow trout (RT)(Oncorhynchus mykiss), Arctic charr (AC)(Salvelinus alpinus), and Atlantic salmon (AS)(Salmo salar) mapping panels. Results Clock1 duplicates mapped to linkage groups RT-8/-24, AC-16/-13 and AS-2/-18. Clock3/NPAS2-like genes mapped to RT-9/-20, AC-20/-43, and AS-5. Most of these linkage group regions containing the Clock gene duplicates were derived from the most recent 4R whole genome duplication event specific to the salmonids. These linkage groups contain quantitative trait loci (QTL) for life history and growth traits (i.e., reproduction and cell cycling). Comparative synteny analyses with other model teleost species reveal a high degree of conservation for genes in these chromosomal regions suggesting that functionally related or co-regulated genes are clustered in syntenic blocks. For example, anti-müllerian hormone (amh), regulating sexual maturation, and ornithine decarboxylase antizymes (oaz1 and oaz2), regulating cell cycling, are contained within these syntenic blocks. Conclusions Synteny analyses indicate that regions homologous to major life-history QTL regions in salmonids contain many candidate genes that are likely to influence reproduction and cell cycling. The order of these genes is highly conserved across the vertebrate species examined, and as such, these genes may make up a functional cluster of genes that are likely co-regulated. CLOCK, as a transcription factor, is found within this block and therefore has the potential to cis-regulate the processes influenced by these genes. Additionally, clock-controlled genes (CCGs) are located in other life-history QTL regions within salmonids suggesting that at least in part, trans-regulation of these QTL regions may also occur via Clock expression. PMID:20670436

Ocean acidification affects redox-balance and ion-homeostasis in the life-cycle stages of Emiliania huxleyi.

PubMed

Rokitta, Sebastian D; John, Uwe; Rost, Björn

2012-01-01

Ocean Acidification (OA) has been shown to affect photosynthesis and calcification in the coccolithophore Emiliania huxleyi, a cosmopolitan calcifier that significantly contributes to the regulation of the biological carbon pumps. Its non-calcifying, haploid life-cycle stage was found to be relatively unaffected by OA with respect to biomass production. Deeper insights into physiological key processes and their dependence on environmental factors are lacking, but are required to understand and possibly estimate the dynamics of carbon cycling in present and future oceans. Therefore, calcifying diploid and non-calcifying haploid cells were acclimated to present and future CO(2) partial pressures (pCO(2); 38.5 Pa vs. 101.3 Pa CO(2)) under low and high light (50 vs. 300 µmol photons m(-2) s(-1)). Comparative microarray-based transcriptome profiling was used to screen for the underlying cellular processes and allowed to follow up interpretations derived from physiological data. In the diplont, the observed increases in biomass production under OA are likely caused by stimulated production of glycoconjugates and lipids. The observed lowered calcification under OA can be attributed to impaired signal-transduction and ion-transport. The haplont utilizes distinct genes and metabolic pathways, reflecting the stage-specific usage of certain portions of the genome. With respect to functionality and energy-dependence, however, the transcriptomic OA-responses resemble those of the diplont. In both life-cycle stages, OA affects the cellular redox-state as a master regulator and thereby causes a metabolic shift from oxidative towards reductive pathways, which involves a reconstellation of carbon flux networks within and across compartments. Whereas signal transduction and ion-homeostasis appear equally OA-sensitive under both light intensities, the effects on carbon metabolism and light physiology are clearly modulated by light availability. These interactive effects can be attributed to the influence of OA and light on the redox equilibria of NAD and NADP, which function as major sensors for energization and stress. This generic mode of action of OA may therefore provoke similar cell-physiological responses in other protists.

USING LIFE CYCLE ASSESSMENT TOOLS FOR INTEGRATED PRODUCT POLICY

EPA Science Inventory

The European Union's new Integrated Product Policy directs governments and companies to consider the entire product life cycle, from cradle to grave, in their environmental decision-making process. A life-cycle based approach is intended to lead toward true environmental improvem...

41 CFR 109-1.5304 - Deviations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle control...

41 CFR 109-1.5304 - Deviations.

Code of Federal Regulations, 2013 CFR

2013-07-01

... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle control...

41 CFR 109-1.5304 - Deviations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle control...

41 CFR 109-1.5304 - Deviations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle control...

41 CFR 109-1.5304 - Deviations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... High Risk Personal Property § 109-1.5304 Deviations. (a) Life cycle control determinations. When the HFO approves a contractor program containing controls, other than life cycle control consistent with... Secretary for Procurement and Assistance Management. A HFO's decision not to provide life-cycle control...

Development of computer software for pavement life cycle cost analysis.

DOT National Transportation Integrated Search

1988-01-01

The life cycle cost analysis program (LCCA) is designed to automate and standardize life cycle costing in Virginia. It allows the user to input information necessary for the analysis, and it then completes the calculations and produces a printed copy...

EVALUATING THE GREENNESS OF IONIC LIQUIDS VIA LIFE CYCLE ASSESSMENT

EPA Science Inventory

Ionic Liquids have been suggested as "greener" replacements to traditional solvents. However, the environmental impacts of the life cycle phases have not been studied. Such a "cradle to gate" Life Cycle Assessment (LCA) for comparing the environmental impact of various solvents...

Crash Attenuator Data Collection and Life Cycle Tool Development

DOT National Transportation Integrated Search

2014-06-14

This research study was aimed at data collection and development of a decision support tool for life cycle cost assessment of crash attenuators. Assessing arrenuator life cycle costs based on in-place expected costs and not just the initial cost enha...

LIFE CYCLE DESIGN FRAMEWORK AND DEMONSTRATION PROJECTS - PROFILES OF AT&T AND ALLIED SIGNAL

EPA Science Inventory

This document offers guidance and practical experience for integrating environmental considerations into product system development. Life cycle design seeks to minimize the environmental burden associated with a product's life cycle from raw materials acquisition through manufact...

Garvin Heath | NREL

Science.gov Websites

& Impacts Analysis Group in the Strategic Energy Analysis Center. Areas of Expertise Life cycle environmental impacts of energy technologies, including externalities Life cycle assessment Sustainability ;Life Cycle Assessment of a Parabolic Trough Concentrating Solar Power Plant and the Impacts of Key

From life cycle talking to taking action

EPA Science Inventory

The series of Life Cycle Management (LCM) conferences has aimed to create a platform for users and developers of life cycle assessment tools to share their experiences as they challenge traditional environmental management practices, which are narrowly confined (“gate-to-gate”) a...

Moving Up the CMMI Capability and Maturity Levels Using Simulation

DTIC Science & Technology

2008-01-01

Alternative Process Tools, Including NPV and ROI 6 Figure 3: Top-Level View of the Full Life-Cycle Version of the IEEE 12207 PSIM, Including IV&V Layer 19...Figure 4: Screenshot of the Incremental Version Model 19 Figure 5: IEEE 12207 PSIM Showing the Top-Level Life-Cycle Phases 22 Figure 6: IEEE 12207 ...Software Detailed Design for the IEEE 12207 Life- Cycle Process 24 Figure 8: Incremental Life Cycle PSIM Configured for a Specific Project Using SEPG

User’s Guide for Naval Material Command’s Life Cycle Cost (FLEX) Model.

DTIC Science & Technology

1982-04-01

MATERIAL COMMANDl’S 3 LIFE CYCLE COST (FLEX) MODEL Icc FoIuhrInomto -- -- P ea eCo tc Pleale Cona, ______ _____-Thims document rc~ ofl 5C72 -lot REPORT...Material Command’s Life Cycle Cost (FLEX) Prep. 4/82 ___ Model ______________ ______________ 7. Author(s) S. Performing Organization Rapt. No. R. Dress (ESA...WANG 1I. Abstract (Limit: 200 words) The FLEX-9E life cycle cost comp~uter model is a user-oriented methodology accommodating most cost structures and

Quantification of the Service Life Extension and Environmental Benefit of Chloride Exposed Self-Healing Concrete

PubMed Central

Van Belleghem, Bjorn; Van den Heede, Philip; Van Tittelboom, Kim; De Belie, Nele

2016-01-01

Formation of cracks impairs the durability of concrete elements. Corrosion inducing substances, such as chlorides, can enter the matrix through these cracks and cause steel reinforcement corrosion and concrete degradation. Self-repair of concrete cracks is an innovative technique which has been studied extensively during the past decade and which may help to increase the sustainability of concrete. However, the experiments conducted until now did not allow for an assessment of the service life extension possible with self-healing concrete in comparison with traditional (cracked) concrete. In this research, a service life prediction of self-healing concrete was done based on input from chloride diffusion tests. Self-healing of cracks with encapsulated polyurethane precursor formed a partial barrier against immediate ingress of chlorides through the cracks. Application of self-healing concrete was able to reduce the chloride concentration in a cracked zone by 75% or more. As a result, service life of steel reinforced self-healing concrete slabs in marine environments could amount to 60–94 years as opposed to only seven years for ordinary (cracked) concrete. Subsequent life cycle assessment calculations indicated important environmental benefits (56%–75%) for the ten CML-IA (Center of Environmental Science of Leiden University–Impact Assessment) baseline impact indicators which are mainly induced by the achievable service life extension. PMID:28772363

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight cell - Update II

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1992-01-01

An update of validation test results confirming the breakthrough in LEO cycle life of nickel-hydrogen cells containing 26 percent KOH electrolyte is presented. A breakthrough in the LEO cycle life of individual pressure vessel (IPV) nickel-hydrogen cells has been previously reported. The cycle life of boiler plate cells containing 26 percent potassium hydroxide (KOH) electrolyte was about 40,000 LEO cycles, compared to 3500 cycles for cells containing 31 percent KOH. The cycle regime was a stressful accelerated LEO, which consisted of a 27.5 min charge followed by a 17.5 min discharge (2X normal rate). The depth-of-discharge was 80 percent. Six 48-Ah Hughes recirculation design IPV nickel-hydrogen flight battery cells are being evaluated. Three of the cells contain 26 percent KOH (test cells), and three contain 31 percent KOH (control cells). They are undergoing real time LEO cycle life testing. The cycle regime is a 90-min LEO orbit consisting of a 54-min charge followed by a 36-min discharge. The depth-of-discharge is 80 percent. The cell temperature is maintained at 10 C. The three 31 percent KOH cells failed (cycles 3729, 4165, and 11355). One of the 26 percent KOH cells failed at cycle 15314. The other two 26 percent KOH cells were cycled for over 16,000 cycles during the continuing test.

Information system life-cycle and documentation standards, volume 1

NASA Technical Reports Server (NTRS)

Callender, E. David; Steinbacher, Jody

1989-01-01

The Software Management and Assurance Program (SMAP) Information System Life-Cycle and Documentation Standards Document describes the Version 4 standard information system life-cycle in terms of processes, products, and reviews. The description of the products includes detailed documentation standards. The standards in this document set can be applied to the life-cycle, i.e., to each phase in the system's development, and to the documentation of all NASA information systems. This provides consistency across the agency as well as visibility into the completeness of the information recorded. An information system is software-intensive, but consists of any combination of software, hardware, and operational procedures required to process, store, or transmit data. This document defines a standard life-cycle model and content for associated documentation.

Effects of partial circadian adjustments on sleep and vigilance quality during simulated night work.

PubMed

Chapdelaine, Simon; Paquet, Jean; Dumont, Marie

2012-08-01

In most situations, complete circadian adjustment is not recommended for night workers. With complete adjustment, workers experience circadian misalignment when returning on a day-active schedule, causing repeated circadian phase shifts and internal desynchrony. For this reason, partial circadian realignment was proposed as a good compromise to stabilize internal circadian rhythms in night shift workers. However, the extent of partial circadian adjustment necessary to improve sleep and vigilance quality is still a matter of debate. In this study, the effects of small but statistically significant partial circadian adjustments on sleep and vigilance quality were assessed in a laboratory simulation of night work to determine whether they were also of clinical significance. Partial adjustments obtained by phase delay or by phase advance were quantified not only by the phase shift of dim light salivary melatonin onset, but also by the overlap of the episode of melatonin production with the sleep-wake cycle adopted during simulated night work. The effects on daytime sleep and night-time vigilance quality were modest. However, they suggest that even small adjustments by phase delay may decrease the accumulation of sleep debt, whereas the advance strategy improves subjective alertness and mood during night work. Furthermore, absolute phase shifts, by advance or by delay, were associated with improved subjective alertness and mood during the night shift. These strategies need to be tested in the field, to determine whether they can be adapted to real-life situations and provide effective support to night workers. © 2012 European Sleep Research Society.

48 CFR 211.274-1 - General.

Code of Federal Regulations, 2012 CFR

2012-10-01

... on leading practices and embraces open standards, DoD can— (a) Achieve lower life-cycle cost of item management and improve life-cycle property management; (b) Improve operational readiness; (c) Provide reliable accountability of property and asset visibility throughout the life cycle; and (d) Reduce the...

48 CFR 211.274-1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... on leading practices and embraces open standards, DoD can— (a) Achieve lower life-cycle cost of item management and improve life-cycle property management; (b) Improve operational readiness; (c) Provide reliable accountability of property and asset visibility throughout the life cycle; and (d) Reduce the...

48 CFR 211.274-1 - General.

Code of Federal Regulations, 2013 CFR

2013-10-01

... on leading practices and embraces open standards, DoD can— (a) Achieve lower life-cycle cost of item management and improve life-cycle property management; (b) Improve operational readiness; (c) Provide reliable accountability of property and asset visibility throughout the life cycle; and (d) Reduce the...

Reducing Life-Cycle Costs.

ERIC Educational Resources Information Center

Roodvoets, David L.

2003-01-01

Presents factors to consider when determining roofing life-cycle costs, explaining that costs do not tell the whole story; discussing components that should go into the decision (cost, maintenance, energy use, and environmental costs); and concluding that important elements in reducing life-cycle costs include energy savings through increased…

Software security checklist for the software life cycle

NASA Technical Reports Server (NTRS)

Gilliam, D. P.; Wolfe, T. L.; Sherif, J. S.

2002-01-01

A formal approach to security in the software life cycle is essential to protect corporate resources. However, little thought has been given to this aspect of software development. Due to its criticality, security should be integrated as a formal approach in the software life cycle.

EDITORIAL: THE INTERNATIONAL CONFERENCE ON LIFE CYCLE ASSESSMENT

EPA Science Inventory

This is a special issue of Journal of Life Cycle Assessment that includes selected papers from the Internatonal Conference and Exhibition on Life Cycle Assessment (InLCA). In April 2000, the EPA, with co-organizer IERE, held the InLCA conferencethat attracted over 265 attendees (...

LIFE CYCLE DESIGN OF AMORPHOUS SILICON PHOTOVOLTAIC MODULES

EPA Science Inventory

The life cycle design framework was applied to photovoltaic module design. The primary objective of this project was to develop and evaluate design metrics for assessing and guiding the Improvement of PV product systems. Two metrics were used to assess life cycle energy perform...

Test of US Federal Life Cycle Inventory Data Interoperability

EPA Science Inventory

Life cycle assessment practitioners must gather data from a variety of sources. For modeling activities in the US, practitioners may wish to use life cycle inventory data from public databases and libraries provided by US government entities. An exercise was conducted to test if ...

Holistic impact assessment and cost savings of rainwater harvesting at the watershed scale

EPA Science Inventory

We evaluated the impacts of domestic and agricultural rainwater harvesting (RWH) systems in three watersheds within the Albemarle-Pamlico river basin (southeastern U.S.) using life cycle assessment (LCA) and life cycle cost assessment. Life cycle impact assessment (LCIA) categori...

Educational Focuses in Organisational Life Cycles.

ERIC Educational Resources Information Center

Miller, Harry G.

1985-01-01

Presents four stages frequently associated with the stages of an organization's life cycle: experimentation, growth, maturity, and decline or stability. The author also demonstrates that the impact of employment and thus training related to organizational life cycles suggests a need for understanding the technical preparation required for…

PRODUCT LIFE-CYCLE ASSESSMENT: INVENTORY GUIDELINES AND PRINCIPLES

EPA Science Inventory

The Life Cycle Assessment (LCA) can be used as an objective technical tool to evaluate the environmental consequences of a product, process, or activity holistically, across its entire life cycle. omplete LCA can be viewed as consisting of three complementary components (1) the i...

1977 Nationwide Personal Transportation Study : a life cycle of travel by the American family

DOT National Transportation Integrated Search

1981-07-01

This report provides information about family trips and travel from the point of view of the family life cycle, using data from the 1977 Nationwide Personal Transportation Study. Daily travel characteristics of families in stages of four life cycles ...

A Language Translator for a Computer Aided Rapid Prototyping System.

DTIC Science & Technology

1988-03-01

PROBLEM ................... S B. THE TRADITIONAL "WATERFALL LIFE CYCLE" .. ............... 14 C. RAPID PROTOTYPING...feature of everyday life for almost the entire industrialized world. Few governments or businesses function without the aid of computer systems. Com...engineering. B. TIE TRADITIONAL "WATERFALL LIFE CYCLE" I. Characteristics The traditional method of software engineering is the "waterfall life cycle

A Growth Model for the Academic Program Life Cycle (APLC): A Theoretical and Empirical Analysis. IR Applications, Volume 33

ERIC Educational Resources Information Center

Acquah, Edward H. K.

2012-01-01

The academic program life cycle (APLC) concept states each program's life flows through several stages: introduction, growth, maturity, and decline. A mixed-influence diffusion growth model is fitted to annual enrollment data on academic programs to analyze the factors determining progress of academic programs through their life cycles. The…

The numbers game: quantitative analysis of Neorickettsia sp. propagation through complex life cycle of its digenean host using real-time qPCR.

PubMed

Greiman, Stephen E; Tkach, Vasyl V

2016-07-01

Bacteria of the genus Neorickettsia are obligate intracellular endosymbionts of parasitic flukes (Digenea) and are passed through the entire complex life cycle of the parasite by vertical transmission. Several species of Neorickettsia are known to cause diseases in domestic animals, wildlife, and humans. Quantitative data on the transmission of the bacteria through the digenean life cycle is almost completely lacking. This study quantified for the first time the abundance of Neorickettsia within multiple stages of the life cycle of the digenean Plagiorchis elegans. Snails Lymnaea stagnalis collected from a pond in North Dakota were screened for the presence of digenean cercariae, which were subsequently tested for the presence of Neorickettsia. Three L. stagnalis were found shedding P. elegans cercariae infected with Neorickettsia. These snails were used to initiate three separate laboratory life cycles and obtain all life cycle stages for bacterial quantification. A quantitative real-time PCR assay targeting the GroEL gene was developed to enumerate Neorickettsia sp. within different stages of the digenean life cycle. The number of bacteria significantly increased throughout all stages, from eggs to adults. The two largest increases in number of bacteria occurred during the period from eggs to cercariae and from 6-day metacercariae to 48-h juvenile worms. These two periods seem to be the most important for Neorickettsia propagation through the complex digenean life cycle and maturation in the definitive host.

Comparative muscle development of scyphozoan jellyfish with simple and complex life cycles.

PubMed

Helm, Rebecca R; Tiozzo, Stefano; Lilley, Martin K S; Lombard, Fabien; Dunn, Casey W

2015-01-01

Simple life cycles arise from complex life cycles when one or more developmental stages are lost. This raises a fundamental question - how can an intermediate stage, such as a larva, be removed, and development still produce a normal adult? To address this question, we examined the development in several species of pelagiid jellyfish. Most members of Pelagiidae have a complex life cycle with a sessile polyp that gives rise to ephyrae (juvenile medusae); but one species within Pelagiidae, Pelagia noctiluca, spends its whole life in the water column, developing from a larva directly into an ephyra. In many complex life cycles, adult features develop from cell populations that remain quiescent in larvae, and this is known as life cycle compartmentalization and may facilitate the evolution of direct life cycles. A second type of metamorphic processes, known as remodeling, occurs when adult features are formed through modification of already differentiated larval structures. We examined muscle morphology to determine which of these alternatives may be present in Pelagiidae. We first examined the structure and development of polyp and ephyra musculature in Chrysaora quinquecirrha, a close relative of P. noctiluca with a complex life cycle. Using phallotoxin staining and confocal microscopy, we verified that polyps have four to six cord muscles that persist in strobilae and discovered that cord muscles is physically separated from ephyra muscle. When cord muscle is removed from ephyra segments, normal ephyra muscle still develops. This suggests that polyp cord muscle is not necessary for ephyra muscle formation. We also found no evidence of polyp-like muscle in P. noctiluca. In both species, we discovered that ephyra muscle arises de novo in a similar manner, regardless of the life cycle. The separate origins of polyp and ephyra muscle in C. quinquecirrha and the absence of polyp-like muscle in P. noctiluca suggest that polyp muscle is not remodeled to form ephyra muscle in Pelagiidae. Life cycle stages in Scyphozoa may instead be compartmentalized. Because polyp muscle is not directly remodeled, this may have facilitated the loss of the polyp stage in the evolution of P. noctiluca.

A Darwinian approach to the origin of life cycles with group properties.

PubMed

Rashidi, Armin; Shelton, Deborah E; Michod, Richard E

2015-06-01

A selective explanation for the evolution of multicellular organisms from unicellular ones requires knowledge of both selective pressures and factors affecting the response to selection. Understanding the response to selection is particularly challenging in the case of evolutionary transitions in individuality, because these transitions involve a shift in the very units of selection. We develop a conceptual framework in which three fundamental processes (growth, division, and splitting) are the scaffold for unicellular and multicellular life cycles alike. We (i) enumerate the possible ways in which these processes can be linked to create more complex life cycles, (ii) introduce three genes based on growth, division and splitting that, acting in concert, determine the architecture of the life cycles, and finally, (iii) study the evolution of the simplest five life cycles using a heuristic model of coupled ordinary differential equations in which mutations are allowed in the three genes. We demonstrate how changes in the regulation of three fundamental aspects of colonial form (cell size, colony size, and colony cell number) could lead unicellular life cycles to evolve into primitive multicellular life cycles with group properties. One interesting prediction of the model is that selection generally favors cycles with group level properties when intermediate body size is associated with lowest mortality. That is, a universal requirement for the evolution of group cycles in the model is that the size-mortality curve be U-shaped. Furthermore, growth must decelerate with size. Copyright © 2015 Elsevier Inc. All rights reserved.

Evaluation de l'eco-efficience des processus de mise a niveau d'helicopteres en tant qu'alternative a la fin de vie

NASA Astrophysics Data System (ADS)

Rancher, Alexandre

Classic industrial production methods generate significant pressures on natural resources as well as environmental constraints related to product end-of-life management. Closed-loop supply chains are often seen as more eco-efficient alternatives, well known to provide substantial economic and environmental benefits at the scale of the product life cycle. This is notably achieved through important reductions in the overall cost of production, in the needs for new materials and energies, and in the proportion of end-of-life components going to landfill. Due to their modular designs and the particular dynamics of helicopter service life, light nonpressurized helicopters have proven to be highly receptive to partial or total remanufacture and upgrade, extending their service life, enhancing their performance and modernizing their equipment, often for only a fraction of the cost of a new aircraft. However, little environmental data is available in order to assess the overall eco-efficiency of helicopter upgrade processes. This study resulted in the creation of a method for the systemic characterization of the processes encountered during the helicopter service life. The arrangement of these processes over time has enabled the construction of helicopter operation cycles, representative of the helicopter service life. These operation cycles have then been characterized, following various criteria based on helicopter designs and usage profiles, in order to study and compare their respective eco-efficiency. A case study is provided to illustrate the application of the method, based on a currently operating industrial business model of helicopter upgrade. This case study intends to provide a first-level assessment of the potential economic, technical and environmental benefits from remanufacturing and upgrading a helicopter, as an alternative production channel. The study found that compared to its replacement, upgrading a former airframe to a more recent design is generally a more eco-efficient decision. Important reductions were found in most of the profiles assessed, notably, reductions of up to 51 % in terms of production costs, 77.5 % in waste going to landfill, and up to 54 % in energy consumption. The method developed can be seen as a decision-helping tool intended for both operators and manufacturers. The method takes into account Design-for-Environment (DfE) guidelines and Material Recovery Opportunities (MRO), providing better understanding of the adaptability of a given design to fulfill the requirements of optimized reverse supply chains.

Earth Without Life: A Systems Model of a Global Abiotic Nitrogen Cycle

NASA Astrophysics Data System (ADS)

Laneuville, M.; Kameya, M.; Cleaves, H. J.

2017-07-01

N is the major component of the atmosphere and plays important roles in biochemistry. Presently, the surface N-cycle is dominated by biology. However, before the origin of life, abiotic N-cycling would have set the stage for the origin of life.

LIFE CYCLE IMPACT ASSESSMENT AN INTRODUCTION AND INTERNATIONAL UPDATE

EPA Science Inventory

Research within the field of Life Cycle Impact Assessment (LCIA) has greatly improved since the work of Heijungs and Guinee in 1992. Within the UNEP / SETAC Life Cycle Initiative an effort is underway to provide recommendations about the direction of research and selection of LC...

Achieving Our Environmental Sustainability Goals: The Opportunities and Pitfalls of Applying Life Cycle Thinking

EPA Science Inventory

An increasing number of people around the world are beginning to realize that a systems approach, such as life cycle thinking, is necessary to truly achieve environmental sustainability. Without the holistic perspective that life cycle thinking provides, our actions risk leading ...

Dealing with Emergy Algebra in the Life Cycle Assessment Framework

EPA Science Inventory

The Life Cycle Inventory (LCI) represents one of the four steps of the Life Cycle Assessment (LCA) methodology, which is a standardized procedure (ISO 14040:2006) to estimate the environmental impacts generated by the production, use and disposal of goods and services. In this co...

Comparison of energy-based indicators used in life cycle assessment tools for buildings

EPA Science Inventory

Traditionally, building rating systems focused on, among others, energy used during operational stage. Recently, there is a strong push by these rating systems to include the life cycle energy use of buildings, particularly using Life Cycle Assessment (LCA), by offering credits t...

10 CFR 436.24 - Uncertainty analyses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Procedures for Life Cycle Cost Analyses § 436.24 Uncertainty analyses. If particular items of cost data or... impact of uncertainty on the calculation of life cycle cost effectiveness or the assignment of rank order... and probabilistic analysis. If additional analysis casts substantial doubt on the life cycle cost...

10 CFR 436.24 - Uncertainty analyses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Procedures for Life Cycle Cost Analyses § 436.24 Uncertainty analyses. If particular items of cost data or... impact of uncertainty on the calculation of life cycle cost effectiveness or the assignment of rank order... and probabilistic analysis. If additional analysis casts substantial doubt on the life cycle cost...

10 CFR 436.24 - Uncertainty analyses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Procedures for Life Cycle Cost Analyses § 436.24 Uncertainty analyses. If particular items of cost data or... impact of uncertainty on the calculation of life cycle cost effectiveness or the assignment of rank order... and probabilistic analysis. If additional analysis casts substantial doubt on the life cycle cost...

10 CFR 436.24 - Uncertainty analyses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Procedures for Life Cycle Cost Analyses § 436.24 Uncertainty analyses. If particular items of cost data or... impact of uncertainty on the calculation of life cycle cost effectiveness or the assignment of rank order... and probabilistic analysis. If additional analysis casts substantial doubt on the life cycle cost...

LIFE-CYCLE IMPACT ASSESSMENT DEMONSTRATION FOR THE BGU-24

EPA Science Inventory

The primary goal of this project was to develop and demonstrate a life-cycle impact assessment (LCIA) approach using existing life-cycle inventory (LCI) data on one of the propellants, energetics, and pyrotechnic (PEP) materials of interest to the U.S. Department of Defense (DoD)...

A Game to Teach the Life Cycles of Fungi

ERIC Educational Resources Information Center

Blum, Abraham

1976-01-01

Presented is a biological game utilized to teach fungi life cycles to secondary biology students. The game is designed to overcome difficulties of correlating schematic drawings with images seen through the microscope, correlating life cycles of fungi and host, and understanding cyclic development of fungi. (SL)

10 CFR 436.11 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Life Cycle Cost Analyses § 436.11 Definitions. As used in this subpart— Base Year means the fiscal year in which a life cycle cost analysis is conducted. Building energy system means an energy conservation... building that improve energy efficiency and are life cycle cost effective and that involve energy...

Integrated Metrics for Improving the Life Cycle Approach to Assessing Product System Sustainability

EPA Science Inventory

Life cycle approaches are critical for identifying and managing to reduce burdens in the sustainability of product systems. While these methods can indicate potential environmental impacts of a product, current Life Cycle Assessment (LCA) methods fail to integrate the multiple im...

The Process of Life Cycle Cost Analysis: Projecting Economic Consequences of Design Decisions

ERIC Educational Resources Information Center

AIA Journal, 1976

1976-01-01

Life-cycle cost analysis deals with both present and future costs and attempts to relate the two as a basis for making decisions. This article lays the groundwork for a better understanding of the techniques of life-cycle cost analysis. (Author/MLF)

THE EPA'S EMERGING FOCUS ON LIFE CYCLE ASSESSMENT

EPA Science Inventory

EPA has been actively engaged in LCA research since 1990 to help advance the methodology and application of life cycle thinking in decision making. Across the Agency consideration of the life cycle concept is increasing in the development of policies and programs. A major force i...

The effect of plasma electrolytic oxidation on the mean stress sensitivity of the fatigue life of the 6082 aluminum alloy

NASA Astrophysics Data System (ADS)

Winter, L.; Morgenstern, R.; Hockauf, K.; Lampke, T.

2016-03-01

In this work the mean stress influence on the high cycle fatigue behavior of the plasma electrolytic oxidized (PEO) 6082 aluminum alloy (AlSi1MgMn) is investigated. The present study is focused on the fatigue life time and the susceptibility of fatigue-induced cracking of the oxide coating and their dependence on the applied mean stress. Systematic work is done comparing conditions with and without PEO treatment, which have been tested using three different load ratios. For the uncoated substrate the cycles to failure show a significant dependence on the mean stress, which is typical for aluminum alloys. With increased load ratio and therefore increased mean stress, the fatigue strength decreases. The investigation confirms the well-known effect of PEO treatment on the fatigue life: The fatigue strength is significantly reduced by the PEO process, compared to the uncoated substrate. However, also the mean stress sensitivity of the fatigue performance is reduced. The fatigue limit is not influenced by an increasing mean stress for the PEO treated conditions. This effect is firstly shown in these findings and no explanation for this effect can be found in literature. Supposedly the internal compressive stresses and the micro-cracks in the oxide film have a direct influence on the crack initiation and growth from the oxide film through the interface and in the substrate. Contrary to these findings, the susceptibility of fatigue-induced cracking of the oxide coating is influenced by the load ratio. At tension-tension loading a large number of cracks, which grow partially just in the aluminum substrate, are present. With decreasing load ratio to alternating tension-compression stresses, the crack number and length increases and shattering of the oxide film is more pronounced due to the additional effective compressive part of the load cycle.

NASA Lewis advanced IPV nickel-hydrogen technology

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Britton, Doris L.

1993-01-01

Individual pressure vessel (IPV) nickel-hydrogen technology was advanced at NASA Lewis and under Lewis contracts. Some of the advancements are as follows: to use 26 percent potassium hydroxide electrolyte to improve cycle life and performance, to modify the state of the art cell design to eliminate identified failure modes and further improve cycle life, and to develop a lightweight nickel electrode to reduce battery mass, hence reduce launch and/or increase satellite payload. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 accelerated LEO cycles at 80 percent DOD compared to 3,500 cycles for cells containing 31 percent KOH. Results of the boiler plate cell tests have been validated at NWSC, Crane, Indiana. Forty-eight ampere-hour flight cells containing 26 and 31 percent KOH have undergone real time LEO cycle life testing at an 80 percent DOD, 10 C. The three cells containing 26 percent KOH failed on the average at cycle 19,500. The three cells containing 31 percent KOH failed on the average at cycle 6,400. Validation testing of NASA Lewis 125 Ah advanced design IPV nickel-hydrogen flight cells is also being conducted at NWSC, Crane, Indiana under a NASA Lewis contract. This consists of characterization, storage, and cycle life testing. There was no capacity degradation after 52 days of storage with the cells in the discharged state, on open circuit, 0 C, and a hydrogen pressure of 14.5 psia. The catalyzed wall wick cells have been cycled for over 22,694 cycles with no cell failures in the continuing test. All three of the non-catalyzed wall wick cells failed (cycles 9,588; 13,900; and 20,575). Cycle life test results of the Fibrex nickel electrode has demonstrated the feasibility of an improved nickel electrode giving a higher specific energy nickel-hydrogen cell. A nickel-hydrogen boiler plate cell using an 80 mil thick, 90 percent porous Fibrex nickel electrode has been cycled for 10,000 cycles at 40 percent DOD.

Fractographic evaluation of creep effects on strain-controlled fatigue-cracking of AISI 304LC and 316 stainless steel

NASA Technical Reports Server (NTRS)

Oldrieve, R. E.

1978-01-01

Analysis of high temperature low cycle fatigue of AISI 304LC and 316 stainless steels by the method of strainrange partitioning results in four separate strainrange versus life relationships, depending upon the way in which creep-strain and plastic strain are combined within a cycle. Fractography is used in this investigation of the creep-fatigue interaction associated with these cycles. The PP and PC-cycle fractures were transgranular. The PC-cycle resulted in fewer cycles of initiation and shorter total cyclic life for the same applied inelastic strainrange. The CC-cycle had mixed transgranular and intergranular fracture, fewer cycles of initiation and shorter cycle life than PP or PC. The CP-cycle had fully integranular cracking, and failed in fewer cycles than were required for cracks to initate for PP,PC, and CC.

Silver-silver sulfate reference electrodes for use in lead-acid batteries

NASA Astrophysics Data System (ADS)

Ruetschi, Paul

Electrochemical properties of silver-silver sulfate reference electrodes for lead-acid batteries are described, and the following possible applications discussed: Determination of individual capacities of positive and negative plates. Monitoring individual electrode behavior during deep discharge and cell reversal. Optimization charge or discharge parameters, by controlling the current such that pre-determined limits of positive or negative half-cell potential are respected. Observation of acid concentration differences, for example due to acid stratification, by measuring diffusion potentials (concentration-cell voltages). Detection of defective cells, and defective plate sets, in a string of cells, at the end of their service life. Silver-silver sulfate reference electrodes, permanently installed in lead-acid cells, may be a means to improve battery management, and therewith to improve reliability and service life. In vented batteries, reference electrodes may be used to limit positive plate polarization during charge, or float-charge. Limiting the positive half-cell potential to an upper, pre-set value would permit to keep anodic corrosion as low as possible. During cycling, discharge could be terminated when the half-cell potential of the positive electrode has dropped to a pre-set limit. This would prevent excessive discharge of the positive electrodes, which could result in an improvement of cycle life. In valve-regulated batteries, reference electrodes may be used to adjust float-charge conditions such as to assure sufficient cathodic polarization of the negative electrodes, in order to avoid sulfation. The use of such reference electrodes could be beneficial particularly in multi-cell batteries, with overall voltages above 12 V, operated in a partial-state-of-charge.

Intimacy and the life cycle in the marital relationships of the Scottish elite during the long eighteenth century.

PubMed

Barclay, Katie

2011-01-01

Traditionally marriage has been treated as one step in the life cycle, between youth and old age, singleness and widowhood. Yet an approach to the life cycle that treats marriage as a single step in a person's life is overly simplistic. During the eighteenth century many marriages were of considerable longevity during which time couples aged together and power dynamics within the home were frequently renegotiated to reflect changing circumstances. This study explores how intimacy developed and changed over the life cycle of marriage and what this meant for power, through a study of the correspondence of two elite Scottish couples.

On the Relationship between Solar Wind Speed, Earthward-Directed Coronal Mass Ejections, Geomagnetic Activity, and the Sunspot Cycle Using 12-Month Moving Averages

NASA Technical Reports Server (NTRS)

Wilson, Robert M.; Hathaway, David H.

2008-01-01

For 1996 .2006 (cycle 23), 12-month moving averages of the aa geomagnetic index strongly correlate (r = 0.92) with 12-month moving averages of solar wind speed, and 12-month moving averages of the number of coronal mass ejections (CMEs) (halo and partial halo events) strongly correlate (r = 0.87) with 12-month moving averages of sunspot number. In particular, the minimum (15.8, September/October 1997) and maximum (38.0, August 2003) values of the aa geomagnetic index occur simultaneously with the minimum (376 km/s) and maximum (547 km/s) solar wind speeds, both being strongly correlated with the following recurrent component (due to high-speed streams). The large peak of aa geomagnetic activity in cycle 23, the largest on record, spans the interval late 2002 to mid 2004 and is associated with a decreased number of halo and partial halo CMEs, whereas the smaller secondary peak of early 2005 seems to be associated with a slight rebound in the number of halo and partial halo CMEs. Based on the observed aaM during the declining portion of cycle 23, RM for cycle 24 is predicted to be larger than average, being about 168+/-60 (the 90% prediction interval), whereas based on the expected aam for cycle 24 (greater than or equal to 14.6), RM for cycle 24 should measure greater than or equal to 118+/-30, yielding an overlap of about 128+/-20.

The Life Cycle of Images: Revisiting the Ethical Treatment of the Art Therapy Image

ERIC Educational Resources Information Center

Hinz, Lisa D.

2013-01-01

Using the metaphor of the human life cycle, the author of this viewpoint suggests that consideration of the birth, life, and death of images made in art therapy may promote a new perspective on their ethical treatment. A developmental view of images encourages art therapists to see art images as living entities that undergo a natural life cycle.…

The Life Cycle of Everyday Stuff.

ERIC Educational Resources Information Center

Reeske, Mike; Ireton, Shirley Watt

Life cycle assessment is an important tool for technology planning as solid waste disposal options dwindle and energy prices continue to increase. This guide investigates the life cycles of products. The activities in this book are suitable for secondary earth science, environmental science, physical science, or integrated science lessons. The…

A life cycle greenhouse gas inventory of a tree production system

Treesearch

Alissa Kendall; E. Gregory McPherson

2012-01-01

PurposeThis study provides a detailed, process-based life cycle greenhouse gas (GHG) inventory of an ornamental tree production system for urban forestry. The success of large-scale tree planting initiatives for climate protection depends on projects being net sinks for CO2 over their entire life cycle....

Sustainability Analysis | Energy Analysis | NREL

Science.gov Websites

environmental, life-cycle, climate, and other impacts of renewable energy technologies. Photo of a man viewing a energy choices within the complex web of connections between energy and water. Life Cycle Assessment Harmonization Our life cycle assessment harmonization provides lenders, utility executives, and lawmakers with

10 CFR 434.607 - Life cycle cost analysis criteria.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Life cycle cost analysis criteria. 434.607 Section 434.607 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Building Energy Compliance Alternative § 434.607 Life cycle cost...

10 CFR 434.607 - Life cycle cost analysis criteria.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Life cycle cost analysis criteria. 434.607 Section 434.607 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Building Energy Compliance Alternative § 434.607 Life cycle cost...

10 CFR 434.607 - Life cycle cost analysis criteria.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Life cycle cost analysis criteria. 434.607 Section 434.607 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY CODE FOR NEW FEDERAL COMMERCIAL AND MULTI-FAMILY HIGH RISE RESIDENTIAL BUILDINGS Building Energy Compliance Alternative § 434.607 Life cycle cost...

Enhancing TSM&O strategies through life cycle benefit/cost analysis : life cycle benefit/cost analysis & life cycle assessment of adaptive traffic control systems and ramp metering systems.

DOT National Transportation Integrated Search

2015-05-01

The research team developed a comprehensive Benefit/Cost (B/C) analysis framework to evaluate existing and anticipated : intelligent transportation system (ITS) strategies, particularly, adaptive traffic control systems and ramp metering systems, : i...

LIFE CYCLE BASED STUDIES ON BIOETHANOL FUEL FOR SUSTAINABLE TRANSPORTATION: A LITERATURE REVIEW

EPA Science Inventory

A literature search was conducted and revealed 45 publications (1996-2005) that compare bio-ethanol systems to conventional fuel on a life-cycle basis, or using life cycle assessment. Feedstocks, such as sugar beets, wheat, potato, sugar cane, and corn, have been investigated in...

Life cycle assessment of a commercial rainwater harvesting system compared with a municipal water supply system

EPA Science Inventory

Building upon previously published life cycle assessment (LCA) methodologies, we conducted an LCA of a commercial rainwater harvesting (RWH) system and compared it to a municipal water supply (MWS) system adapted to Washington, D.C. Eleven life cycle impact assessment (LCIA) indi...

LIFE-CYCLE IMPACT ASSESSMENT DEMONSTRATION FOR THE GBU-24

EPA Science Inventory

The primary goal of this project was to develop and demonstrate a life-cycle impact assessment (LCIA) approach using existing life-cycle inventory (LCI) data on one of the propellants, energetics, and pyro-technic (PEP) materials of interest to the U.S. Department of Defense (DoD...

Life-cycle energy and emissions inventories for motorcycles, diesel automobiles, school buses, electric buses, Chicago rail, and New York City rail

DOT National Transportation Integrated Search

2009-05-01

The development of life-cycle energy and emissions factors for passenger transportation modes : is critical for understanding the total environmental costs of travel. Previous life-cycle studies : have focused on the automobile given its dominating s...

LIFE CYCLE DESIGN OF AIR INTAKE MANIFOLDS; PHASE I: 2.0 L FORD CONTOUR AIR INTAKE MANIFOLD

EPA Science Inventory

The project team applied the life cycle design methodology to the design analysis of three alternative air intake manifolds: a sand cast aluminum, brazed aluminum tubular, and nylon composite. The design analysis included a life cycle inventory analysis, environmental regulatory...

THE INTERNATIONAL WORKSHOP ON ELECTRICITY DATA FOR LIFE CYCLE INVENTORIES

EPA Science Inventory

A three day workshop was held in October 2001 to discuss life cycle inventory data for electricity production. Electricity was selected as the topic for discussion since it features very prominently in the LCA results for most product life cycles, yet there is no consistency in h...

10 CFR 436.13 - Presuming cost-effectiveness results.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Methodology and Procedures for Life Cycle Cost Analyses § 436.13 Presuming cost-effectiveness results. (a) If... life cycle cost-effective without further analysis. (b) A Federal agency may presume that an investment in an energy or water conservation measure retrofit to an existing Federal building is not life cycle...

76 FR 34271 - Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles Management Unit, Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-13

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,671] Hewlett Packard, Global Parts Supply Chain, Global Product Life Cycles Management Unit, Including Teleworkers Reporting to... Supply Chain, Global Product Life Cycles Management Unit, including teleworkers reporting to Houston...

7 CFR 3560.65 - Reserve account.

Code of Federal Regulations, 2014 CFR

2014-01-01

...-year period. The reserve account analysis is based on either a Capital Needs Assessment or life cycle... Assessment or as part of the original life cycle cost analysis. The cost of conducting either a Capital Needs... Needs Assessment or life cycle cost analysis may be included in the loan financing. (b) For ownership...

7 CFR 3560.65 - Reserve account.

Code of Federal Regulations, 2013 CFR

2013-01-01

...-year period. The reserve account analysis is based on either a Capital Needs Assessment or life cycle... Assessment or as part of the original life cycle cost analysis. The cost of conducting either a Capital Needs... Needs Assessment or life cycle cost analysis may be included in the loan financing. (b) For ownership...

LCACCESS: A GLOBAL DIRECTORY OF LIFE CYCLE ASSESSMENT RESOURCES

EPA Science Inventory

LCAccess is an EPA-sponsored website intended to promote the use of Life Cycle Assessment (LCA) in business decision-making by faciliatating access to data sources that are useful in developing a life cycle inventory (LCI). While LCAccess does not itself contain data, it is a sea...

78 FR 16676 - Agency Information Collection Activities; Proposed Collection; Comment Request; Draft Guidance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... Industry and FDA Staff; Total Product Life Cycle: Infusion Pump--Premarket Notification [510(k... for Industry and FDA Staff; Total Product Life Cycle: Infusion Pump--Premarket Notification [510(k... Staff; Total Product Life Cycle: Infusion Pump--Premarket Notification [510(k)] Submissions--0910-NEW...

LCACCESS: MAKING LIFE CYCLE DATA AVAILABLE VIA THE INTERNET(SYSTEMS ANLAYSIS BRANCH, SUSTAINABLE TECHNOLOGY DIVISION, NRMRL)

EPA Science Inventory

The lack of readily available, quality environmental life cycle inventory (LCI) data is often a barrier to manufacturers, among others, for incorporating life cycle considerations into their decision-making process. While much progress has been made on standardizing and improving...

FUNDAMENTALS OF LIFE CYCLE ASSESSMENT AND OFF-THE-SHELF SOFTWARE DEMONSTRATION

EPA Science Inventory

As the name implies, Life Cycle Assesssment (LCA) evaluates the entire life cycle of a product, process, activity, or service, not just simple economics at the time of delivery. This course on LCA covers the following issues:
Basic principles of LCA for use in producing, des...

Models of the Organizational Life Cycle: Applications to Higher Education.

ERIC Educational Resources Information Center

Cameron, Kim S.; Whetten, David A.

1983-01-01

A review of models of group and organization life cycle development is provided and the applicability of those models for institutions of higher education are discussed. An understanding of the problems and characteristics present in different life cycle stages can help institutions manage transitions more effectively. (Author/MLW)

Life Cycle of a Pencil.

ERIC Educational Resources Information Center

Reeske, Mike

2000-01-01

Explains a project called "Life Cycle of a Pencil" which was developed by the National Science Teachers Association (NSTA) and the U.S. Environmental Protection Agency (USEPA). Describes the life cycle of a pencil in stages starting from the first stage of design to the sixth stage of product disposal. (YDS)

[TRANSFORMATIONS OF LIFE CYCLES IN THE EVOLUTIONARY HISTORY OF TRYPANOSOMATIDS. MACROTRANSFORMATIONS].

PubMed

Frolov, A O; Malysheva, M N; Kostygov, A Yu

2015-01-01

The review concerns analysis of life cycle macrotransformations in the evolutionary history of trypanosomatids. The term "macrotransformations" stands for evolutionary processes leading to the establishment of heteroxenous and secondary homoxenous life cycles within Trypanosomatidae. There were three direct macrotransformations in the evolution of the group resulting in the rise of heteroxenous genera Leishmania, Trypanosoma and Phytomonas, and one case of reverse macrotransformation in trypanosomes of T. (b.) brucei group. The issues of the origin, diversity and phylogeny of taxa whose emergence resulted from macrotransformations of life cycles of homoxenous trypanosomatids.

Are the Performance Based Logistics Prophets Using Science or Alchemy to Create Life-Cycle Affordability? Using Theory to Predict the Efficacy of Performance Based Logistics

DTIC Science & Technology

2013-10-01

Based Logistics Prophets Using Science or Alchemy to Create Life-Cycle Affordability? Using Theory to Predict the Efficacy of Performance Based...Using Science or Alchemy to Create Life-Cycle Affordability? Using Theory to Predict the Efficacy of Performance Based Logistics 5a. CONTRACT NUMBER 5b...Are the PBL Prophets Using Science or Alchemy to Create Life Cycle Affordability? 328Defense ARJ, October 2013, Vol. 20 No. 3 : 325–348 Defense

Life cycle environmental performance of renewable building materials in the context of residential construction : phase II research report: an extension to the 2005 phase I research report. Module C, Life-cycle inventory of hardwood lumber manufacturing in the Northeast and North Central United States.

Treesearch

Richard Bergman; Scott A. Bowe

2008-01-01

The goal of this study was to find the environmental impact of hardwood lumber production through a gate-to-gate Life-Cycle Inventory (LCI) on hardwood sawmills in the northeast and northcentral (NE/NC) United States. Primary mill data was collected per CORRIM Research Guidelines (CORRIM 2001). Life-cycle analysis is beyond the scope of the study.

Life cycle environmental performance of renewable building materials in the context of residential construction : phase II research report: an extension to the 2005 phase I research report. Module L, Life-cycle inventory of hardwood lumber manufacturing in the Southeastern United States.

Treesearch

Richard D. Bergman; Scott A. Bowe

2010-01-01

The goal of this study was to gain an understanding of the environmental impact of hardwood lumber production through a gate-to-gate life-cycle inventory (LCI) of hardwood sawmills in the Southeastern United States (SE). Primary mill data were collected per Consortium on Research for Renewable Industrial Materials (CORRIM) Research Guidelines. Life-cycle impact...

Investigation of the High-Cycle Fatigue Life of Selective Laser Melted and Hot Isostatically Pressed Ti-6Al-4v

DTIC Science & Technology

2015-03-26

INVESTIGATION OF THE HIGH -CYCLE FATIGUE LIFE OF SELECTIVE LASER MELTED AND HOT ISOSTATICALLY PRESSED TI-6AL-4V THESIS Kevin D. Rekedal...ENY-MS-15-M-212 INVESTIGATION OF THE HIGH -CYCLE FATIGUE LIFE OF SELECTIVE LASER MELTED AND HOT ISOSTATICALLY PRESSED TI-6AL-4V THESIS...AFIT-ENY-MS-15-M-212 INVESTIGATION OF THE HIGH -CYCLE FATIGUE LIFE OF SELECTIVE LASER MELTED AND HOT ISOSTATICALLY PRESSED TI-6AL-4V

Making the Mark: The Role of Adenosine Modifications in the Life Cycle of RNA Viruses.

PubMed

Gonzales-van Horn, Sarah R; Sarnow, Peter

2017-06-14

Viral epitranscriptomics is a newly emerging field that has identified unique roles for RNA modifications in modulating life cycles of RNA viruses. Despite the observation of a handful of modified viral RNAs five decades ago, very little was known about how these modifications regulate viral life cycles, until recently. Here we review the pro- and anti-viral effects of methyl-6-adenosine in distinct viral life cycles, the role of 2' O-methyl modifications in RNA stability and innate immune sensing, and functions of adenosine to inosine modifications in retroviral life cycles. With roles for over 100 modifications in RNA still unknown, this is a rapidly emerging field that is destined to suggest novel antiviral therapies. Copyright © 2017 Elsevier Inc. All rights reserved.

Evolution of dispersal in spatially and temporally variable environments: The importance of life cycles.

PubMed

Massol, François; Débarre, Florence

2015-07-01

Spatiotemporal variability of the environment is bound to affect the evolution of dispersal, and yet model predictions strongly differ on this particular effect. Recent studies on the evolution of local adaptation have shown that the life cycle chosen to model the selective effects of spatiotemporal variability of the environment is a critical factor determining evolutionary outcomes. Here, we investigate the effect of the order of events in the life cycle on the evolution of unconditional dispersal in a spatially heterogeneous, temporally varying landscape. Our results show that the occurrence of intermediate singular strategies and disruptive selection are conditioned by the temporal autocorrelation of the environment and by the life cycle. Life cycles with dispersal of adults versus dispersal of juveniles, local versus global density regulation, give radically different evolutionary outcomes that include selection for total philopatry, evolutionary bistability, selection for intermediate stable states, and evolutionary branching points. Our results highlight the importance of accounting for life-cycle specifics when predicting the effects of the environment on evolutionarily selected trait values, such as dispersal, as well as the need to check the robustness of model conclusions against modifications of the life cycle. © 2015 The Author(s). Evolution © 2015 The Society for the Study of Evolution.

Life cycle greenhouse gas emissions and freshwater consumption of Marcellus shale gas.

PubMed

Laurenzi, Ian J; Jersey, Gilbert R

2013-05-07

We present results of a life cycle assessment (LCA) of Marcellus shale gas used for power generation. The analysis employs the most extensive data set of any LCA of shale gas to date, encompassing data from actual gas production and power generation operations. Results indicate that a typical Marcellus gas life cycle yields 466 kg CO2eq/MWh (80% confidence interval: 450-567 kg CO2eq/MWh) of greenhouse gas (GHG) emissions and 224 gal/MWh (80% CI: 185-305 gal/MWh) of freshwater consumption. Operations associated with hydraulic fracturing constitute only 1.2% of the life cycle GHG emissions, and 6.2% of the life cycle freshwater consumption. These results are influenced most strongly by the estimated ultimate recovery (EUR) of the well and the power plant efficiency: increase in either quantity will reduce both life cycle freshwater consumption and GHG emissions relative to power generated at the plant. We conclude by comparing the life cycle impacts of Marcellus gas and U.S. coal: The carbon footprint of Marcellus gas is 53% (80% CI: 44-61%) lower than coal, and its freshwater consumption is about 50% of coal. We conclude that substantial GHG reductions and freshwater savings may result from the replacement of coal-fired power generation with gas-fired power generation.

The components of kin competition.

PubMed

Van Dyken, J David

2010-10-01

It is well known that competition among kin alters the rate and often the direction of evolution in subdivided populations. Yet much remains unclear about the ecological and demographic causes of kin competition, or what role life cycle plays in promoting or ameliorating its effects. Using the multilevel Price equation, I derive a general equation for evolution in structured populations under an arbitrary intensity of kin competition. This equation partitions the effects of selection and demography, and recovers numerous previous models as special cases. I quantify the degree of kin competition, α, which explicitly depends on life cycle. I show how life cycle and demographic assumptions can be incorporated into kin selection models via α, revealing life cycles that are more or less permissive of altruism. As an example, I give closed-form results for Hamilton's rule in a three-stage life cycle. Although results are sensitive to life cycle in general, I identify three demographic conditions that give life cycle invariant results. Under the infinite island model, α is a function of the scale of density regulation and dispersal rate, effectively disentangling these two phenomena. Population viscosity per se does not impede kin selection. © 2010 The Author(s). Journal compilation © 2010 The Society for the Study of Evolution.

A life cycle cost economics model for projects with uniformly varying operating costs. [management planning

NASA Technical Reports Server (NTRS)

Remer, D. S.

1977-01-01

A mathematical model is developed for calculating the life cycle costs for a project where the operating costs increase or decrease in a linear manner with time. The life cycle cost is shown to be a function of the investment costs, initial operating costs, operating cost gradient, project life time, interest rate for capital and salvage value. The results show that the life cycle cost for a project can be grossly underestimated (or overestimated) if the operating costs increase (or decrease) uniformly over time rather than being constant as is often assumed in project economic evaluations. The following range of variables is examined: (1) project life from 2 to 30 years; (2) interest rate from 0 to 15 percent per year; and (3) operating cost gradient from 5 to 90 percent of the initial operating costs. A numerical example plus tables and graphs is given to help calculate project life cycle costs over a wide range of variables.

Association of a trait-like bias towards the perception of negative subjective life events with risk of developing premenstrual symptoms.

PubMed

Gonda, Xenia; Fountoulakis, Konstantinos N; Csukly, Gabor; Telek, Tamas; Pap, Dorottya; Rihmer, Zoltan; Bagdy, Gyorgy

2010-04-16

Premenstrual symptoms affect the majority of healthy women. Premenstrual symptomatology has earlier been linked to stress and a state-like alteration in the perception of life events in the late-luteal phase of the menstrual cycle. We hypothesised that there is also a trait-like negative bias in the perception of life events evident throughout the whole cycle which is associated with the likelihood to manifest more marked symptoms in the late-luteal phase of the cycle. 88 healthy women completed the PRISM calendar for three consecutive cycles and the Objective and Subjective Event Checklist during the follicular phase of the first cycle. Association between PRISM score change from the follicular through the late-luteal phase and life event variables was investigated by Generalized Linear Model Analysis (GENMOD). The PRISM score change showed a significant negative association with the ratio of positive subjective life events and a significant positive association with the ratio of negative subjective life events. There were no significant results in case of the objective life events. Our results indicate that women manifesting a more marked increase of symptoms from the late follicular through the late-luteal phase of the menstrual cycle are more likely to notice negative subjective life events and less likely to notice positive subjective life events. This suggest a trait-like negative bias in the perception of life events present throughout the whole reproductive cycle which may play an important role in the emergence of premenstrual symptoms. Copyright 2010 Elsevier Inc. All rights reserved.

Life cycle inventory energy consumption and emissions for biodiesel versus petroleum diesel fueled construction vehicles.

PubMed

Pang, Shih-Hao; Frey, H Christopher; Rasdorf, William J

2009-08-15

Substitution of soy-based biodiesel fuels for petroleum diesel will alter life cycle emissions for construction vehicles. A life cycle inventory was used to estimate fuel cycle energy consumption and emissions of selected pollutants and greenhouse gases. Real-world measurements using a portable emission measurement system (PEMS) were made forfive backhoes, four front-end loaders, and six motor graders on both fuels from which fuel consumption and tailpipe emission factors of CO, HC, NO(x), and PM were estimated. Life cycle fossil energy reductions are estimated it 9% for B20 and 42% for B100 versus petroleum diesel based on the current national energy mix. Fuel cycle emissions will contribute a larger share of total life cycle emissions as new engines enter the in-use fleet. The average differences in life cycle emissions for B20 versus diesel are: 3.5% higher for NO(x); 11.8% lower for PM, 1.6% higher for HC, and 4.1% lower for CO. Local urban tailpipe emissions are estimated to be 24% lower for HC, 20% lower for CO, 17% lower for PM, and 0.9% lower for NO(x). Thus, there are environmental trade-offs such as for rural vs urban areas. The key sources of uncertainty in the B20 LCI are vehicle emission factors.

Using project life-cycles as guide for timing the archival of scientific data and supporting documentation

NASA Astrophysics Data System (ADS)

Martinez, E.; Glassy, J. M.; Fowler, D. K.; Khayat, M.; Olding, S. W.

2014-12-01

The NASA Earth Science Data Systems Working Groups (ESDSWG) focuses on improving technologies and processes related to science discovery and preservation. One particular group, the Data Preservation Practices, is defining a set of guidelines to aid data providers in planning both what to submit for archival, and when to submit artifacts, so that the archival process can begin early in the project's life cycle. This has the benefit of leveraging knowledge within the project before staff roll off to other work. In this poster we describe various project archival use cases and identify possible archival life cycles that map closely to the pace and flow of work. To understand "archival life cycles", i.e., distinct project phases that produce archival artifacts such as instrument capabilities, calibration reports, and science data products, the workig group initially mapped the archival requirements defined in the Preservation Content Specification to the typical NASA project life cycle. As described in the poster, this work resulted in a well-defined archival life cycle, but only for some types of projects; it did not fit well for condensed project life cycles experienced within airborne and balloon campaigns. To understand the archival process for projects with compressed cycles, the working group gathered use cases from various communities. This poster will describe selected uses cases that provided insight into the unique flow of these projects, as well as proposing archival life cycles that map artifacts to projects with compressed timelines. Finally, the poster will conclude with some early recommendations for data providers, which will be captured in a formal Guidelines document - to be published in 2015.

A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours

PubMed Central

Undevia, Samir D.; Innocenti, Federico; Ramirez, Jacqueline; House, Larry; Desai, Apurva A.; Skoog, Linda A.; Singh, Deepti A.; Karrison, Theodore; Kindler, Hedy L.; Ratain, Mark J.

2009-01-01

Purpose To investigate the safety and pharmacokinetics of R(+)XK469, a quinoxaline analogue, in patients with advanced refractory solid tumours. Preclinical studies suggested that efficacy was independent of schedule but that toxicity was decreased by dividing the dose. Methods R(+)XK469 was initially administered as a 30 min intravenous infusion on days 1–5 of a 21-d cycle. Based on the demonstration of a long half-life, the dosing schedule was subsequently amended to infusion on days 1, 3 and 5 of a 21-d cycle. An alternate single-dose schedule of once every 21 d was also explored. Blood samples were collected for pharmaco-kinetic studies. Results Dose-limiting toxicity (DLT) was neutropaenia. There was significant interindividual variability in clearance as evidenced by a coefficient of variation of 46%. A flat-dosing scheme (not based on body surface area) was justified by the absence of correlation between clearance and body surface area. A partial response was observed in a patient with nasopharyngeal carcinoma. Conclusions The recommended phase II doses are 850–1100 mg/d on days 1, 3 and 5 of a 21-d cycle and 2500 mg on day 1 of a 21-d cycle. The observed interpatient pharmacokinetic variability should prompt investigation into the presence of genetic polymorphism in relevant metabolizing enzymes. PMID:18650079

Employing Synergetic Effect of Doping and Thin Film Coating to Boost the Performance of Lithium-Ion Battery Cathode Particles

PubMed Central

Patel, Rajankumar L.; Jiang, Ying-Bing; Choudhury, Amitava; Liang, Xinhua

2016-01-01

Atomic layer deposition (ALD) has evolved as an important technique to coat conformal protective thin films on cathode and anode particles of lithium ion batteries to enhance their electrochemical performance. Coating a conformal, conductive and optimal ultrathin film on cathode particles has significantly increased the capacity retention and cycle life as demonstrated in our previous work. In this work, we have unearthed the synergetic effect of electrochemically active iron oxide films coating and partial doping of iron on LiMn1.5Ni0.5O4 (LMNO) particles. The ionic Fe penetrates into the lattice structure of LMNO during the ALD process. After the structural defects were saturated, the iron started participating in formation of ultrathin oxide films on LMNO particle surface. Owing to the conductive nature of iron oxide films, with an optimal film thickness of ~0.6 nm, the initial capacity improved by ~25% at room temperature and by ~26% at an elevated temperature of 55 °C at a 1C cycling rate. The synergy of doping of LMNO with iron combined with the conductive and protective nature of the optimal iron oxide film led to a high capacity retention (~93% at room temperature and ~91% at 55 °C) even after 1,000 cycles at a 1C cycling rate. PMID:27142704

Life in the dark: metagenomic evidence that a microbial slime community is driven by inorganic nitrogen metabolism.

PubMed

Tetu, Sasha G; Breakwell, Katy; Elbourne, Liam D H; Holmes, Andrew J; Gillings, Michael R; Paulsen, Ian T

2013-06-01

Beneath Australia's large, dry Nullarbor Plain lies an extensive underwater cave system, where dense microbial communities known as 'slime curtains' are found. These communities exist in isolation from photosynthetically derived carbon and are presumed to be chemoautotrophic. Earlier work found high levels of nitrite and nitrate in the cave waters and a high relative abundance of Nitrospirae in bacterial 16S rRNA clone libraries. This suggested that these communities may be supported by nitrite oxidation, however, details of the inorganic nitrogen cycling in these communities remained unclear. Here we report analysis of 16S rRNA amplicon and metagenomic sequence data from the Weebubbie cave slime curtain community. The microbial community is comprised of a diverse assortment of bacterial and archaeal genera, including an abundant population of Thaumarchaeota. Sufficient thaumarchaeotal sequence was recovered to enable a partial genome sequence to be assembled, which showed considerable synteny with the corresponding regions in the genome of the autotrophic ammonia oxidiser Nitrosopumilus maritimus SCM1. This partial genome sequence, contained regions with high sequence identity to the ammonia mono-oxygenase operon and carbon fixing 3-hydroxypropionate/4-hydroxybutyrate cycle genes of N. maritimus SCM1. Additionally, the community, as a whole, included genes encoding key enzymes for inorganic nitrogen transformations, including nitrification and denitrification. We propose that the Weebubbie slime curtain community represents a distinctive microbial ecosystem, in which primary productivity is due to the combined activity of archaeal ammonia-oxidisers and bacterial nitrite oxidisers.

Monoclonal Antibodies to Intracellular Stages of Cryptosporidium parvum Define Life Cycle Progression In Vitro.

PubMed

Wilke, Georgia; Ravindran, Soumya; Funkhouser-Jones, Lisa; Barks, Jennifer; Wang, Qiuling; VanDussen, Kelli L; Stappenbeck, Thaddeus S; Kuhlenschmidt, Theresa B; Kuhlenschmidt, Mark S; Sibley, L David

2018-06-27

Among the obstacles hindering Cryptosporidium research is the lack of an in vitro culture system that supports complete life development and propagation. This major barrier has led to a shortage of widely available anti- Cryptosporidium antibodies and a lack of markers for staging developmental progression. Previously developed antibodies against Cryptosporidium were raised against extracellular stages or recombinant proteins, leading to antibodies with limited reactivity across the parasite life cycle. Here we sought to create antibodies that recognize novel epitopes that could be used to define intracellular development. We identified a mouse epithelial cell line that supported C. parvum growth, enabling immunization of mice with infected cells to create a bank of monoclonal antibodies (MAbs) against intracellular parasite stages while avoiding the development of host-specific antibodies. From this bank, we identified 12 antibodies with a range of reactivities across the parasite life cycle. Importantly, we identified specific MAbs that can distinguish different life cycle stages, such as trophozoites, merozoites, type I versus II meronts, and macrogamonts. These MAbs provide valuable tools for the Cryptosporidium research community and will facilitate future investigation into parasite biology. IMPORTANCE Cryptosporidium is a protozoan parasite that causes gastrointestinal disease in humans and animals. Currently, there is a limited array of antibodies available against the parasite, which hinders imaging studies and makes it difficult to visualize the parasite life cycle in different culture systems. In order to alleviate this reagent gap, we created a library of novel antibodies against the intracellular life cycle stages of Cryptosporidium We identified antibodies that recognize specific life cycle stages in distinctive ways, enabling unambiguous description of the parasite life cycle. These MAbs will aid future investigation into Cryptosporidium biology and help illuminate growth differences between various culture platforms. Copyright © 2018 Wilke et al.

Effect of complete and partial removable dentures on chewing movements.

PubMed

Gonçalves, T M S V; Vilanova, L S R; Gonçalves, L M; Rodrigues Garcia, R C M

2014-03-01

Partial or complete edentulism impairs mastication. However, it is unclear how the chewing cycle is affected by prosthetics. We evaluated the chewing movements of patients fitted with complete (CD) or removable partial denture (RPD). A total of 29 subjects were kinesiographically evaluated during chewing of peanuts and Optocal portions in a random sequence. The subjects were divided into two groups according to prosthesis type. Group RPD was composed of 14 partially edentulous patients using a lower distal extension RPD (mean age 61 ± 8 years), and group CD contained 15 completely edentulous patients using CD (mean age 65·9 ± 7·9 years) in both jaws. Opening, closing, occlusal and masticatory cycle times, movement angle (opening and closing), maximum velocity (opening and closing), total area and chewing cycle amplitudes were evaluated. The results were subjected to anova and Tukey's HSD test at a significance level of 5%. The RPD group exhibited shorter opening and closing phases and masticatory cycle time (P < 0·05). Maximum velocities were also higher in the RPD group, irrespective of the test material (P < 0·05). The area and amplitude of the chewing envelope was smaller in the CD group (P < 0·0001). The test material did not influence chewing cycles in any of the parameters evaluated (P > 0·05). RPD wearers use a faster chewing sequence with greater vertical and lateral jaw excursions compared with CD wearers. © 2013 John Wiley & Sons Ltd.

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

PubMed Central

Bhat, Shreyas; Hasenhuetl, Peter S.; Kasture, Ameya; El-Kasaby, Ali; Baumann, Michael H.; Blough, Bruce E.; Sucic, Sonja; Sandtner, Walter; Freissmuth, Michael

2017-01-01

Point mutations in SLC6 transporters cause misfolding, which can be remedied by pharmacochaperones. The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, releasers (amphetamines, which promote the exchange mode), and more recently, discovered partial substrates. We hypothesized that partial substrates trapped the transporter in one or several states of the transport cycle. This conformational trapping may also be conducive to folding. We selected naphthylpropane-2-amines of the phenethylamine library (PAL) including the partial substrate PAL1045 and its congeners PAL287 and PAL1046. We analyzed their impact on the transport cycle of SERT by biochemical approaches and by electrophysiological recordings; substrate-induced peak currents and steady-state currents monitored the translocation of substrate and co-substrate Na+ across the lipid bilayer and the transport cycle, respectively. These experiments showed that PAL1045 and its congeners bound with different affinities (ranging from nm to μm) to various conformational intermediates of SERT during the transport cycle. Consistent with the working hypothesis, PAL1045 was the most efficacious compound in restoring surface expression and transport activity to the folding-deficient mutant SERT-601PG602-AA. These experiments provide a proof-of-principle for a rational search for pharmacochaperones, which may be useful to restore function to clinically relevant folding-deficient transporter mutants. PMID:28842491

Computation techniques and computer programs to analyze Stirling cycle engines using characteristic dynamic energy equations

NASA Technical Reports Server (NTRS)

Larson, V. H.

1982-01-01

The basic equations that are used to describe the physical phenomena in a Stirling cycle engine are the general energy equations and equations for the conservation of mass and conversion of momentum. These equations, together with the equation of state, an analytical expression for the gas velocity, and an equation for mesh temperature are used in this computer study of Stirling cycle characteristics. The partial differential equations describing the physical phenomena that occurs in a Stirling cycle engine are of the hyperbolic type. The hyperbolic equations have real characteristic lines. By utilizing appropriate points along these curved lines the partial differential equations can be reduced to ordinary differential equations. These equations are solved numerically using a fourth-fifth order Runge-Kutta integration technique.

Life Cycle Assessment and Carbon Footprint in the Wine Supply-Chain

NASA Astrophysics Data System (ADS)

Pattara, Claudio; Raggi, Andrea; Cichelli, Angelo

2012-06-01

Global warming represents one of the most critical internationally perceived environmental issues. The growing, and increasingly global, wine sector is one of the industries which is under increasing pressure to adopt approaches for environmental assessment and reporting of product-related greenhouse gas emissions. The International Organization for Vine and Wine has recently recognized the need to develop a standard and objective methodology and a related tool for calculating carbon footprint (CF). This study applied this tool to a wine previously analyzed using the life cycle assessment (LCA) methodology. The objective was to test the tool as regards both its potential and possible limitations, and thus to assess its suitability as a standard tool. Despite the tool's user-friendliness, a number of limitations were noted including the lack of accurate baseline data, a partial system boundary and the impossibility of dealing with the multi-functionality issue. When the CF and LCA results are compared in absolute terms, large discrepancies become obvious due to a number of different assumptions, as well as the modeling framework adopted. Nonetheless, in relative terms the results seem to be quite consistent. However, a critical limitation of the CF methodology was its focus on a single issue, which can lead to burden shifting. In conclusion, the study confirmed the need for both further improvement and adaptation to additional contexts and further studies to validate the use of this tool in different companies.

The use of life-cycle assessment to evaluate the environmental impacts of growing genetically modified, nitrogen use-efficient canola.

PubMed

Strange, Alison; Park, Julian; Bennett, Richard; Phipps, Richard

2008-05-01

Agriculture, particularly intensive crop production, makes a significant contribution to environmental pollution. A variety of canola (Brassica napus) has been genetically modified to enhance nitrogen use efficiency, effectively reducing the amount of fertilizer required for crop production. A partial life-cycle assessment adapted to crop production was used to assess the potential environmental impacts of growing genetically modified, nitrogen use-efficient (GMNUE) canola in North Dakota and Minnesota compared with a conventionally bred control variety. The analysis took into account the entire production system used to produce 1 tonne of canola. This comprised raw material extraction, processing and transportation, as well as all agricultural field operations. All emissions associated with the production of 1 tonne of canola were listed, aggregated and weighted in order to calculate the level of environmental impact. The findings show that there are a range of potential environmental benefits associated with growing GMNUE canola. These include reduced impacts on global warming, freshwater ecotoxicity, eutrophication and acidification. Given the large areas of canola grown in North America and, in particular, Canada, as well as the wide acceptance of genetically modified varieties in this area, there is the potential for GMNUE canola to reduce pollution from agriculture, with the largest reductions predicted to be in greenhouse gases and diffuse water pollution.

Life cycle assessment and carbon footprint in the wine supply-chain.

PubMed

Pattara, Claudio; Raggi, Andrea; Cichelli, Angelo

2012-06-01

Global warming represents one of the most critical internationally perceived environmental issues. The growing, and increasingly global, wine sector is one of the industries which is under increasing pressure to adopt approaches for environmental assessment and reporting of product-related greenhouse gas emissions. The International Organization for Vine and Wine has recently recognized the need to develop a standard and objective methodology and a related tool for calculating carbon footprint (CF). This study applied this tool to a wine previously analyzed using the life cycle assessment (LCA) methodology. The objective was to test the tool as regards both its potential and possible limitations, and thus to assess its suitability as a standard tool. Despite the tool's user-friendliness, a number of limitations were noted including the lack of accurate baseline data, a partial system boundary and the impossibility of dealing with the multi-functionality issue. When the CF and LCA results are compared in absolute terms, large discrepancies become obvious due to a number of different assumptions, as well as the modeling framework adopted. Nonetheless, in relative terms the results seem to be quite consistent. However, a critical limitation of the CF methodology was its focus on a single issue, which can lead to burden shifting. In conclusion, the study confirmed the need for both further improvement and adaptation to additional contexts and further studies to validate the use of this tool in different companies.

Taming troubled teens: The social production of mental morbidity amongst young mothers in Pelotas, Brazil

PubMed Central

Béhague, D.P.; Gonçalves, H.D.; Gigante, D.; Kirkwood, B.R.

2012-01-01

Explanations for the association between teen-childbearing and subsequent mental morbidity vary considerably, from those based on neurological theories of development to those investigating underlying social and economic determinants. Based on longitudinal epidemiological and ethnographic sub-studies of the 1982 Pelotas birth cohort study, this paper explores the hypothesis that teen childbearing and subsequent mental morbidity have become associated through the interplay of culture, society, and biology in situations where teen pregnancy has become a stigmatised object of scientific and public health attention. Results show that the effect of teen childbearing on subsequent mental morbidity remained significant in the multivariate analysis. Ethnographic analysis, together with epidemiological effect modification analyses, suggest that this association is partially accounted for by the fact that it is more pronounced amongst a specific subgroup of women of low socio-economic status who, being more politicised about societal injustice, were also more critically engaged with – and thus troubled by – the inequitable institutionalisation of life-cycle transitions. With time, these women became highly critical of the institutionalised identification of early childbearing as a key violation of life-cycle norms and the differential class-based application of scientific knowledge on its causes and consequences. Public health campaigns should consider how the age-based institutionalisation of developmental norms has enabled the stigmatisation of those identified as transgressors. PMID:22196249

Life cycle assessment of nutrient removal technologies for the treatment of anaerobic digestion supernatant and its integration in a wastewater treatment plant.

PubMed

Rodriguez-Garcia, G; Frison, N; Vázquez-Padín, J R; Hospido, A; Garrido, J M; Fatone, F; Bolzonella, D; Moreira, M T; Feijoo, G

2014-08-15

The supernatant resulting from the anaerobic digestion of sludge generated by wastewater treatment plants (WWTP) is an attractive flow for technologies such as partial nitritation-anammox (CANON), nitrite shortcut (NSC) and struvite crystallization processes (SCP). The high concentration of N and P and its low flow rate facilitate the removal of nutrients under more favorable conditions than in the main water line. Despite their operational and economic benefits, the environmental burdens of these technologies also need to be assessed to prove their feasibility under a more holistic perspective. The potential environmental implications of these technologies were assessed using life cycle assessment, first at pilot plant scale, later integrating them in a modeled full WWTP. Pilot plant results reported a much lower environmental impact for N removal technologies than SCP. Full-scale modeling, however, highlighted that the differences between technologies were not relevant once they are integrated in a WWTP. The impacts associated with the WWTP are slightly reduced in all categories except for eutrophication, where a substantial reduction was achieved using NSC, SCP, and especially when CANON and SCP were combined. This study emphasizes the need for assessing wastewater treatment technologies as part of a WWTP rather than as individual processes and the utility of modeling tools for doing so. Copyright © 2014 Elsevier B.V. All rights reserved.

Educated Parents, Educated Children: Toward a Multiple Life Cycles Education Policy

ERIC Educational Resources Information Center

Sticht, Thomas G.

2010-01-01

Given the important intergenerational effects of parents' education level on the achievement of their children, education policies should shift from a focus on one life cycle to a focus on "multiple life cycles". Such a policy would explicitly recognize that adults transfer their educational achievements to the achievement of their…

Alternative Fuels Data Center

Science.gov Websites

specified volumes of renewable fuels according to the categories below. EISA established life cycle GHG demonstrate a 20% reduction in life cycle GHG emissions. Advanced Biofuel: Any fuel derived from cellulosic or categories may be used to meet this category. Fuels in this category must demonstrate a life cycle GHG

Learning, Unlearning and Relearning--Knowledge Life Cycles in Library and Information Science Education

ERIC Educational Resources Information Center

Bedford, Denise A. D.

2015-01-01

The knowledge life cycle is applied to two core capabilities of library and information science (LIS) education--teaching, and research and development. The knowledge claim validation, invalidation and integration steps of the knowledge life cycle are translated to learning, unlearning and relearning processes. Mixed methods are used to determine…

Life Cycle Assessment Harmonization | Energy Analysis | NREL

Science.gov Websites

change are excluded from this analysis. The data showed that life cycle greenhouse gas (GHG) emissions Sensitivity Analysis of Biopower Life-Cycle Assessments and Greenhouse Gas Emission, Electric Power Research hydropower, ocean, geothermal, biopower, solar, wind, nuclear, coal, and natural gas technologies. See the

Modeling and Measuring Organization Capital

ERIC Educational Resources Information Center

Atkeson, Andrew; Kehoe, Patrick J.

2005-01-01

Manufacturing plants have a clear life cycle: they are born small, grow substantially with age, and eventually die. Economists have long thought that this life cycle is driven by organization capital, the accumulation of plant-specific knowledge. The location of plants in the life cycle determines the size of the payments, or organization rents,…

Toward Automated Inventory Modeling in Life Cycle Assessment: The Utility of Semantic Data Modeling to Predict Real-WorldChemical Production

EPA Science Inventory

A set of coupled semantic data models, i.e., ontologies, are presented to advance a methodology towards automated inventory modeling of chemical manufacturing in life cycle assessment. The cradle-to-gate life cycle inventory for chemical manufacturing is a detailed collection of ...

Coupling Computer-Aided Process Simulation and Estimations of Emissions and Land Use for Rapid Life Cycle Inventory Modeling

EPA Science Inventory

A methodology is described for developing a gate-to-gate life cycle inventory (LCI) of a chemical manufacturing process to support the application of life cycle assessment in the design and regulation of sustainable chemicals. The inventories were derived by first applying proces...

77 FR 40253 - Reserve Account

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-09

... Agency does not have a general formula that is used for the life cycle cost analysis. The life cycle cost... analysis is defined in 7 CFR 3560.11. The Agency reviews the results of the life cycle cost analysis for... cost analysis. The Agency agrees that the reserve accounts based on a percentage can be underfunded and...

Bypass control valve seal and bearing life cycle test report

NASA Technical Reports Server (NTRS)

Lundback, A. V.

1972-01-01

The operating characteristics of a bypass control valve seal and bearing life cycle tests are reported. Data from the initial assembly, leak, torque, and deflection tests are included along with the cycle life test results and conclusions. The equipment involved was to be used in the nuclear engine for the rocket vehicles program.

System Support/Sustainment Plan Platform for the Defense Enterprise Accounting Management System (DEAMS)

DTIC Science & Technology

2006-12-01

warfighters requirements and identifies system performance short-comings over its life cycle. 15. NUMBER OF PAGES 89 14. SUBJECT TERMS Information...the system performs to warfighters requirements and identifies system performance short-comings over its life cycle. vi...3 II. DEFENSE ACQUISITION LIFE CYCLE CURRENT STAGE ANALYSIS.......5 A. INTRODUCTION

75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... Competition Throughout the Life Cycle of Major Defense Acquisition Programs AGENCY: Defense Acquisition... subcontract level of the MDAP throughout its life cycle as a means to improve contractor performance; and (2...) throughout the program life cycle as a means to improve contractor performance; and (ii) Document the...

75 FR 21632 - Draft Guidance for Industry and Food and Drug Administration Staff; Total Product Life Cycle...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

...] Draft Guidance for Industry and Food and Drug Administration Staff; Total Product Life Cycle: Infusion... the draft guidance document entitled ``Total Product Life Cycle: Infusion Pump--Premarket Notification... this issue of the Federal Register, FDA is announcing a public meeting regarding external infusion...

THE EMERGING FOCUS ON LIFE-CYCLE ASSESSMENT IN THE U. S. ENVIRONMENTAL PROTECTION AGENCY

EPA Science Inventory

EPA has been actively engaged in LCA research since 1990 to help advance the methodology and application of life cycle thinking in decision-making. Across the Agency consideration of the life cycle concept is increasing in the development of policies and programs. A major force i...

Competitive Strategies of States: A Life-Cycle Perspective. EQW Working Papers.

ERIC Educational Resources Information Center

Flynn, Patricia M.

This paper demonstrates that production life-cycle models provide a conceptual framework to analyze systematically the interrelationships between industrial and technological change and human resources. Section II presents the life-cycle model, focusing on its implications for the types and level of employment and skill requirements in an area.…

Developing Students' Understanding of Industrially Relevant Economic and Life Cycle Assessments

ERIC Educational Resources Information Center

Bode, Claudia J.; Chapman, Clint; Pennybaker, Atherly; Subramaniam, Bala

2017-01-01

Training future leaders to understand life cycle assessment data is critical for effective research, business, and sociopolitical decision-making. However, the technical nature of these life cycle reports often makes them challenging for students and other nonexperts to comprehend. Therefore, we outline here the key takeaways from recent economic…

Life cycle assessment part 2: current impact assessment practice.

PubMed

Pennington, D W; Potting, J; Finnveden, G; Lindeijer, E; Jolliet, O; Rydberg, T; Rebitzer, G

2004-07-01

Providing our society with goods and services contributes to a wide range of environmental impacts. Waste generation, emissions and the consumption of resources occur at many stages in a product's life cycle-from raw material extraction, energy acquisition, production and manufacturing, use, reuse, recycling, through to ultimate disposal. These all contribute to impacts such as climate change, stratospheric ozone depletion, photooxidant formation (smog), eutrophication, acidification, toxicological stress on human health and ecosystems, the depletion of resources and noise-among others. The need exists to address these product-related contributions more holistically and in an integrated manner, providing complimentary insights to those of regulatory/process-oriented methodologies. A previous article (Part 1, Rebitzer et al., 2004) outlined how to define and model a product's life cycle in current practice, as well as the methods and tools that are available for compiling the associated waste, emissions and resource consumption data into a life cycle inventory. This article highlights how practitioners and researchers from many domains have come together to provide indicators for the different impacts attributable to products in the life cycle impact assessment (LCIA) phase of life cycle assessment (LCA).

[Update on the epidemiology of hydatidosis. Hydatid echinococci: species; life cycles; epidemiologic consequences].

PubMed

Euzéby, J

1990-05-01

Human hydatidosis results from infestation by two species of Echinococcus. (1) E. vogeli, the life-cycle of which occurs in amazonian forests and involves wild canidae and cuniculidae. (2) E. granulosus, which includes two geographical groups: (a) Northern group, with two sub-species E. g borelis and E. g. canadensis, the life-cycle of which is sylvatic and that are agents of a pulmonary hydatidosis which may affect Man. (b) "European" (actually cosmopolitan) form, with two sub-species: (1) E. q. equinus (equine strain) occurring between dogs and horses and unable to infect Man; (2) E. g. granulosus, with several strains and clones according to the species of their intermediate hosts and which are the agents of synanthropic or sylvatic life-cycles. Man may enter into some of these life cycles, but not into all of them: ovine strains, chiefly, but pig and camel strains also, have a zoonotic incidence. From these data, the author emphasizes the epidemiological features of human hydatidosis, which over-runs the classical rural one, resulting from the drog-sheep life-cycle.

Clinical effectiveness, quality of life and cost-effectiveness of Flaminal® versus Flamazine® in the treatment of partial thickness burns: study protocol for a randomized controlled trial.

PubMed

Rashaan, Zjir M; Krijnen, Pieta; van den Akker-van Marle, M Elske; van Baar, Margriet E; Vloemans, Adrianus F P; Dokter, Jan; Tempelman, Fenike R H; van der Vlies, Cees H; Breederveld, Roelf S

2016-03-05

Partial thickness burns are painful, difficult to manage and can have a negative effect on quality of life through scarring, permanent disfigurement and loss of function. The aim of burn treatment in partial thickness burns is to save lives, stimulate wound healing by creating an optimumly moist wound environment, to have debriding and analgesic effects, protect the wound from infection and be convenient for the patient and caregivers. However, there is no consensus on the optimal treatment of partial thickness wounds. Flaminal® and Flamazine® are two standard treatment options that provide the above mentioned properties in burn treatment. Nevertheless, no randomized controlled study has yet compared these two common treatment modalities in partial thickness burns. Thus, the aim of this study is to evaluate the clinical effectiveness, quality of life and cost-effectiveness of Flaminal® versus Flamazine® in the treatment of partial thickness burns. In this two-arm open multi-center randomized controlled trial, 90 patients will be randomized between Flaminal® and Flamazine® and followed for 12 months. The study population will consist of competent or temporarily non-competent (because of sedation and/or intubation) patients, 18 years of age or older, with acute partial thickness burns and a total body surface area (TBSA) of less than 30 %. The main study outcome is time to complete re-epithelialization (greater than 95 %). Secondary outcome measures include need for grafting, wound colonization/infection, number of dressing changes, pain and anxiety, scar formation, health-related quality of life (HRQoL), and costs. This study will contribute to the optimal treatment of patients with partial thickness burn wounds and will provide evidence on the (cost-)effectiveness and quality of life of Flaminal® versus Flamazine® in the treatment of partial thickness burns. Netherlands Trial Register NTR4486 , registered on 2 April 2014.

Global Distribution, Public Health and Clinical Impact of the Protozoan Pathogen Cryptosporidium

PubMed Central

Putignani, Lorenza; Menichella, Donato

2010-01-01

Cryptosporidium spp. are coccidians, oocysts-forming apicomplexan protozoa, which complete their life cycle both in humans and animals, through zoonotic and anthroponotic transmission, causing cryptosporidiosis. The global burden of this disease is still underascertained, due to a conundrum transmission modality, only partially unveiled, and on a plethora of detection systems still inadequate or only partially applied for worldwide surveillance. In children, cryptosporidiosis encumber is even less recorded and often misidentified due to physiological reasons such as early-age unpaired immunological response. Furthermore, malnutrition in underdeveloped countries or clinical underestimation of protozoan etiology in developed countries contribute to the underestimation of the worldwide burden. Principal key indicators of the parasite distribution were associated to environmental (e.g., geographic and temporal clusters, etc.) and host determinants of the infection (e.g., age, immunological status, travels, community behaviours). The distribution was geographically mapped to provide an updated picture of the global parasite ecosystems. The present paper aims to provide, by a critical analysis of existing literature, a link between observational epidemiological records and new insights on public health, and diagnostic and clinical impact of cryptosporidiosis. PMID:20706669

An attributional life cycle assessment for an Italian residential multifamily building.

PubMed

Vitale, Pierluca; Arena, Umberto

2017-09-06

The study describes an attributional life cycle assessment carried out according to the ISO standards and focused on an Italian multifamily residential building. The aim was developing an exhaustive and reliable inventory of high-quality primary data, comparing the environmental impacts along the three stages of the building life cycle. The pre-use phase takes into account the production of all the construction materials, transportation, and on-site assembling. The use phase quantifies the resource consumptions for 50 years of the building utilization and ordinary maintenance. The end-of-life phase includes the building demolition and the management of generated wastes. The results quantify how the design criteria affect the environmental performances of the residential building along its life cycle. The role of the pre-use phase appears remarkable for global warming potential (GWP), due to the huge impacts of steel and concrete production processes. The use phase gives the largest contributions, which reach 77% and 84% of the total, for the categories of global warming and non-renewable energy. The end-of-life phase provides limited avoided impacts. A comparative analysis quantifies the improvements achievable with an alternative type of partitions and external walls. Acronyms: AC: air conditioning; C&DW: construction and demolition waste; CFL: compact fluorescent lamp; DHW: domestic hot water; EC: European Commission; EU: European Union; GDP: gross domestic product; GHG: greenhouse gases; GWP: global warming potential; LCA: life cycle assessment; LCI: life cycle inventory; LCIA: life cycle impact assessment; MFA: material flow analysis; NREP: non-renewable energy potential; RINP: respiratory inorganics potential; WFD: Waste Framework Directive.

[TRANSFORMATIONS OF LIFE CYCLES IN THE EVOLUTIONARY HISTORY OF TRYPANOSOMATIDAE. EXOTRANSFORMATIONS].

PubMed

Frolov, A O; Malysheva, M N; Kostygov, A Yu

2015-01-01

The present review is devoted to the analysis of exotransformations of life cycles in the evolutionary history of trypanosomatids (Kinetoplastea: Trypanosomatidae). Exotransformations are treated as processes associated with the transition of a trypanosomatid to a new host. The result of these transformations comprises both the inclusion of new hosts in life cycles of parasites and also epy formation of parasitic systems de novo. It is shown that exotransformations are one of the main modi in the evolution of trypanosomatids. Different examples of exotransformations of life cycle in all the taxonomic groups of Trypanosomatidae are given.

Product-related research: how research can contribute to successful life-cycle management.

PubMed

Sandner, Peter; Ziegelbauer, Karl

2008-05-01

Declining productivity with decreasing new molecular entity output combined with increased R&D spending is one of the key challenges for the entire pharmaceutical industry. In order to offset decreasing new molecular entity output, life-cycle management activities for established drugs become more and more important to maintain or even expand clinical indication and market opportunities. Life-cycle management covers a whole range of activities from strategic pricing to a next generation product launch. In this communication, we review how research organizations can contribute to successful life-cycle management strategies using phosphodiesterase 5 inhibitors as an example.

[Life cycle of the taiga tick ixodes persulcatus in taiga forests of the eastern Sayan Plateau].

PubMed

Korotkov, Iu S

2014-01-01

The Ixodes persulcatus life cycle has been studied in natural environments of taiga fo- rests in The Eastern Sayan Plateau (56 10' N, 91 30' E). Engorged larvae and nymphs de- velop with a morphogenetic diapause or without diapause, with ratio of these two ways of development for larvae and nymphs 77.25/22.75% and 43.43/56.57%, respectively. The hypothetic season hemipopulation consists of 34.5 +/- 4.5, 50.1 +/- 1.3, 13.2 +/- 4.0 n 2.2% of unfed imagoes, completing 3-year, 4-year, 5-year, and 6-year life cycles, respectively. Mean life span is 3.83 +/- 0.10 years per generation. The "life table" predicting the probability to complete life cycle through phases from egg to adult, was developed.

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight cells-update 2

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1991-01-01

An update of validation test results confirming the breakthrough in low earth orbit (LEO) cycle life of nickel-hydrogen cells containing 26 percent KOH electrolyte is presented. A breakthrough in the LEO cycle life of individual pressure vessel (IPV nickel-hydrogen cells has been previously reported. The cycle life of boiler plate cells containing 26 percent potassium hydroxide (KOH) electrolyte was about 40 000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH. This test was conducted at Hughes Aircraft Company under a NASA Lewis contract. The purpose was to investigate the effect of KOH concentration on cycle life. The cycle regime was a stressful accelerated LEO, which consisted of a 27.5 min charge followed by a 17.5 min discharge (2x normal rate). The depth of discharge (DOD) was 80 percent. The cell temperature was maintained at 23 C. The boiler plate test results are in the process of being validated using flight hardware and real time LEO test at the Naval Weapons Support Center (NWSC), Crane, Indiana under a NASA Lewis Contract. Six 48 Ah Hughes recirculation design IPV nickel-hydrogen flight battery cells are being evaluated. Three of the cells contain 26 percent KOH (test cells), and three contain 31 percent KOH (control cells). They are undergoing real time LEO cycle life testing. The cycle regime is a 90-min LEO orbit consisting of a 54-min charge followed by a 36-min discharge. The depth-of-discharge is 80 percent. The cell temperature is maintained at 10 C. The three 31 percent KOH cells failed (cycles 3729, 4165, and 11355). One of the 26 percent KOH cells failed at cycle 15314. The other two 26 percent KOH cells were cycled for over 16600 cycles during the continuing test.

Life cycle management of analytical methods.

PubMed

Parr, Maria Kristina; Schmidt, Alexander H

2018-01-05

In modern process management, the life cycle concept gains more and more importance. It focusses on the total costs of the process from invest to operation and finally retirement. Also for analytical procedures an increasing interest for this concept exists in the recent years. The life cycle of an analytical method consists of design, development, validation (including instrumental qualification, continuous method performance verification and method transfer) and finally retirement of the method. It appears, that also regulatory bodies have increased their awareness on life cycle management for analytical methods. Thus, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), as well as the United States Pharmacopeial Forum discuss the enrollment of new guidelines that include life cycle management of analytical methods. The US Pharmacopeia (USP) Validation and Verification expert panel already proposed a new General Chapter 〈1220〉 "The Analytical Procedure Lifecycle" for integration into USP. Furthermore, also in the non-regulated environment a growing interest on life cycle management is seen. Quality-by-design based method development results in increased method robustness. Thereby a decreased effort is needed for method performance verification, and post-approval changes as well as minimized risk of method related out-of-specification results. This strongly contributes to reduced costs of the method during its life cycle. Copyright © 2017 Elsevier B.V. All rights reserved.

KOH concentration effect on the cycle life of nickel-hydrogen cells. 4: Results of failure analyse

NASA Technical Reports Server (NTRS)

Lim, H. S.; Verzwyvelt, S. A.

1989-01-01

Effects of KOH concentrations on failure modes and mechanisms of nickel-hydrogen cells were studied using long cycled boiler plate cells containing electrolytes of various KOH concentrations ranging 21 to 36 percent. Life of these cells were up to 40,000 cycles in an accelerated low earth orbit (LEO) cycle regime at 80 percent depth of discharge. An interim life test results were reported earlier in J. Power Sources, 22, 213-220, 1988. The results of final life test, end-of-life cell performance, and teardown analyses are discussed. These teardown analyses included visual observations, measurements of nickel electrode capacity in an electrolyte-flooded cell, dimensional changes of cell components, SEM studies on cell cross section, BET surface area and pore volume distribution in cycled nickel electrodes, and chemical analyses. Cycle life of a nickel-hydrogen cell was improved tremendously as KOH concentration was decreased from 36 to 31 percent and from 31 to 26 percent while effect of further concentration decrease was complicated as described in our earlier report. Failure mode of high concentration (31 to 36 percent) cells was gradual capacity decrease, while that of low concentration (21 to 26 percent) cells was mainly formation of a soft short. Long cycled (25,000 to 40,000 cycles) nickel electrodes were expanded more than 50 percent of the initial value, but no correlation was found between this expansion and measured capacity. All electrodes cycled in low concentration (21 to 26 percent) cells had higher capacity than those cycled in high concentration (31 to 36 percent) cells.

Influence of creep damage on the low cycle thermal-mechanical fatigue behavior of two tantalum base alloys

NASA Technical Reports Server (NTRS)

Sheffler, K. D.; Doble, G. S.

1972-01-01

Low cycle fatigue tests have been performed on the tantalum base alloys T-111 and ASTAR 811C with synchronized, independently programmed temperature and strain cycling. The thermal-mechanical cycles applied fell into three basic categories: these were isothermal cycling, in-phase thermal cycling, and out-of-phase thermal cycling. In-phase cycling was defined as tensile deformation associated with high temperature and compressive deformation with low temperature, while out-of-phase thermal cycling was defined as the reverse case. The in-phase thermal cycling had a pronounced detrimental influence on the fatigue life of both alloys, with the life reduction being greater in the solid solution strengthened T-111 alloy than in the carbide strengthened ASTAR 811C alloy. The out-of-phase tests also showed pronounced effects on the fatigue life of both alloys, although not as dramatic.

Flight Investigation of Effects of Selected Operating Conditions on the Bending and Torsional Moments Encountered by a Helicopter Rotor Blade

NASA Technical Reports Server (NTRS)

Ludi, LeRoy H.

1961-01-01

Flight tests have been conducted with a single-rotor helicopter to determine the effects of partial-power descents with forward speed, high-speed level turns, pull-outs from autorotation, and high-forward-speed high-rotor-speed autorotation on the flapwise bending and torsional moments of the rotor blade. One blade of the helicopter was equipped at 14 percent and 40 percent of the blade radius with strain gages calibrated to measure moments rather than stresses. The results indicate that the maximum moments encountered in partial-power descents with forward speed tend to be generally reduced from the maximum moments encountered during partid-power descents at zero forward speed. High-speed level turns and pull-outs from auto-rotation caused retreating-blade stall which produced torsional moments (values up to 2,400 inch-pounds). at the 14-percent-radius station that were as large as those encountered during the previous investigations of retreating-blade stall (values up t o 2,500 inch-pounds). High-forward- speed high-rotor-speed autorotation produced flapwise bending moments (values up to 7,200 inch-pounds) at the 40-percent-radius station which were as large as the flapwise bending moments (values up to 7,800 inch-pounds) a t the 14-percent-radius station encountered during partial - power vertical descents. The results of the present investigation (tip-speed ratios up to 0.325 and an unaccelerated level-flight mean lift coefficient of about 0.6), in combination with the related results of at zero forward speed produce the largest rotor-blade vibratory moments. However, inasmuch as these large moments occur only during 1 percent of the cycles and 88 percent of the cycles are at moment values less than 70 percent of these maximum values in partial-power descents, other conditions, such as high-speed flight where the large moments are combined with large percentages of time spent,must not be neglected in any rotor-blade service-life assessment.

Life cycle impacts of manufacturing redwood decking in Northern California

Treesearch

Richard D. Bergman; Elaine Oneil; Ivan L. Eastin; Han-Sup Han

2014-01-01

Awareness of the environmental footprint of building construction and use has led to increasing interest in green building. Defining a green building is an evolving process with life cycle inventory and life cycle impact assessment (LCIA) emerging as key tools in that evolution and definition process. This study used LCIA to determine the environmental footprint...

Managing the Life Cycle Risks of Nanomaterials

DTIC Science & Technology

2009-07-01

ISO International Organization for Standardization ISN Institute for Soldier Nanotechnologies LCA Life Cycle Assessment LCCA Life Cycle Cost Analysis...similar to their smaller Existing ISO /TS 27687:2008 Nanotechnologies -- Terminology and definitions for nano-objects -- Nanoparticle, nanofibre and...Nanotechnology Under Development ISO /CD TR 80004-1 Nanotechnologies - Terminology and definitions – Framework ISO /AWI TS 80004-2 Nanotechnologies

Gate-to-gate Life-Cycle Inventory of Hardboard Production in North America

Treesearch

Richard Bergman

2014-01-01

Whole-building life-cycle assessments (LCAs) populated by life-cycle inventory (LCI) data are incorporated into environmental footprint software tools for establishing green building certification by building professionals and code. However, LCI data on some wood building products are still needed to help fill gaps in the data and thus provide a more complete picture...

Conceptual Framework To Extend Life Cycle Assessment Using Near-Field Human Exposure Modeling and High-Throughput Tools for Chemicals

EPA Science Inventory

Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of a product or service. This paper presents a conceptual framework to integrate human health impact assessment with risk screening approaches to extend LCA to include n...

Growing up in the Ocean: Complex Life Cycles of Common Marine Invertebrates

ERIC Educational Resources Information Center

Bennett, Katie; Hiebert, Laurel

2010-01-01

Most people are familiar with the concept that animals come in all shapes and sizes and that the body plan of some animals can completely transform during their lifetime. Well-known examples of such complex life cycles of terrestrial animals include butterflies and frogs. Many people are unaware, however, that complex life cycles are exceedingly…

Guidance on How to Move from Current Practice to Recommended Practice in Life Cycle Impact Assessment (UNEP/SETAC Life Cycle Initiative Publication)

EPA Science Inventory

The report provides guidance on how to move from current practice to recommended practice in Life Cycle Impact Assessment. It is composed of three complementary parts elaborated in the first task force (TFI) of the LCIA programme, with contribution of the other three task forces:

Mining Available Data from the United States Environmental Protection Agency to Support Rapid Life Cycle Inventory Modeling of Chemical Manufacturing

EPA Science Inventory

Demands for quick and accurate life cycle assessments create a need for methods to rapidly generate reliable life cycle inventories (LCI). Data mining is a suitable tool for this purpose, especially given the large amount of available governmental data. These data are typically a...

Defense ADP Acquisition Study.

DTIC Science & Technology

1981-11-30

Logistics ALS - Advanced Logistics System AMP - ADPS Master Plan ANSI - American National Standards Institute APR - Agency Procurement Request ASD(C...Computers IRM - Information Resources Management ISO - International Standards Organization L LCC - Life Cycle Costs LCM - Life Cycle Management LE...man- agement in the process * Lack of a mission orientation . Lack of systems management and life cycle perspectives * Lack of effective leadership

Alternative Approaches to the Family Life Cycle in the Analysis of Housing Consumption.

ERIC Educational Resources Information Center

McLeod, P. B.; Ellis, J. R.

1983-01-01

Used loan-approval data to analyze the effects of life-cycle stage on housing consumption. The detailed typologies were not generally superior to the more simplified approaches, except for per capita consumption. For per capita consumption, price, and quality, clear evidence is found for structural nonhomogeneity across life-cycle stages. (JAC)

De novo Fatty Acid Biosynthesis Contributes Significantly to Establishment of a Bioenergetically Favorable Environment for Vaccinia Virus Infection

PubMed Central

Greseth, Matthew D.; Traktman, Paula

2014-01-01

The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid synthase inhibitor, impaired vaccinia virus production. Here we show that additional inhibitors of this pathway, TOFA and C75, reduce viral yield significantly, with partial rescue provided by exogenous palmitate, the pathway's end-product. Palmitate's major role during infection is not for phospholipid synthesis or protein palmitoylation. Instead, the mitochondrial import and β-oxidation of palmitate are essential, as shown by the impact of etomoxir and trimetazidine, which target these two processes respectively. Moreover, the impact of these inhibitors is exacerbated in the absence of exogenous glucose, which is otherwise dispensable for infection. In contrast to glucose, glutamine is essential for productive viral infection, providing intermediates that sustain the TCA cycle (anaplerosis). Cumulatively, these data suggest that productive infection requires the mitochondrial β-oxidation of palmitate which drives the TCA cycle and energy production. Additionally, infection causes a significant rise in the cellular oxygen consumption rate (ATP synthesis) that is ablated by etomoxir. The biochemical progression of the vaccinia life cycle is not impaired in the presence of TOFA, C75, or etomoxir, although the levels of viral DNA and proteins synthesized are somewhat diminished. However, by reversibly arresting infections at the onset of morphogenesis, and then monitoring virus production after release of the block, we determined that virion assembly is highly sensitive to TOFA and C75. Electron microscopic analysis of cells released into C75 revealed fragmented aggregates of viroplasm which failed to be enclosed by developing virion membranes. Taken together, these data indicate that vaccinia infection, and in particular virion assembly, relies on the synthesis and mitochondrial import of fatty acids, where their β-oxidation drives robust ATP production. PMID:24651651

De novo fatty acid biosynthesis contributes significantly to establishment of a bioenergetically favorable environment for vaccinia virus infection.

PubMed

Greseth, Matthew D; Traktman, Paula

2014-03-01

The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid synthase inhibitor, impaired vaccinia virus production. Here we show that additional inhibitors of this pathway, TOFA and C75, reduce viral yield significantly, with partial rescue provided by exogenous palmitate, the pathway's end-product. Palmitate's major role during infection is not for phospholipid synthesis or protein palmitoylation. Instead, the mitochondrial import and β-oxidation of palmitate are essential, as shown by the impact of etomoxir and trimetazidine, which target these two processes respectively. Moreover, the impact of these inhibitors is exacerbated in the absence of exogenous glucose, which is otherwise dispensable for infection. In contrast to glucose, glutamine is essential for productive viral infection, providing intermediates that sustain the TCA cycle (anaplerosis). Cumulatively, these data suggest that productive infection requires the mitochondrial β-oxidation of palmitate which drives the TCA cycle and energy production. Additionally, infection causes a significant rise in the cellular oxygen consumption rate (ATP synthesis) that is ablated by etomoxir. The biochemical progression of the vaccinia life cycle is not impaired in the presence of TOFA, C75, or etomoxir, although the levels of viral DNA and proteins synthesized are somewhat diminished. However, by reversibly arresting infections at the onset of morphogenesis, and then monitoring virus production after release of the block, we determined that virion assembly is highly sensitive to TOFA and C75. Electron microscopic analysis of cells released into C75 revealed fragmented aggregates of viroplasm which failed to be enclosed by developing virion membranes. Taken together, these data indicate that vaccinia infection, and in particular virion assembly, relies on the synthesis and mitochondrial import of fatty acids, where their β-oxidation drives robust ATP production.

Variations in the Life Cycle of Anemone patens L. (Ranunculaceae) in Wild Populations of Canada

PubMed Central

Kricsfalusy, Vladimir

2016-01-01

Based on a study of a perennial herb Anemone patens L. (Ranunculaceae) in a variety of natural habitats in Saskatchewan, Canada, eight life stages (seed, seedling, juvenile, immature, vegetative, generative, subsenile, and senile) are distinguished and characterized in detail. The species ontogenetic growth patterns are investigated. A. patens has a long life cycle that may last for several decades which leads to the formation of compact clumps. The distribution and age of clumps vary substantially in different environments with different levels of disturbance. The plant ontogeny includes the regular cycle with reproduction occurring through seeds. There is an optional subsenile vegetative disintegration at the end of the life span. The following variations in the life cycle of A. patens are identified: with slower development in young age, with an accelerated development, with omission of the generative stage, with retrogression to previous life stages in mature age, and with vegetative dormancy. The range of variations in the life cycle of A. patens may play an important role in maintaining population stability in different environmental conditions and management regimes. PMID:27376340

Induction of Phase Variation Events in the Life Cycle of the Marine Coccolithophorid Emiliania huxleyi

PubMed Central

Laguna, Richard; Romo, Jesus; Read, Betsy A.; Wahlund, Thomas M.

2001-01-01

Emiliania huxleyi is a unicellular marine alga that is considered to be the world's major producer of calcite. The life cycle of this alga is complex and is distinguished by its ability to synthesize exquisitely sculptured calcium carbonate cell coverings known as coccoliths. These structures have been targeted by materials scientists for applications relating to the chemistry of biomedical materials, robust membranes for high-temperature separation technology, lightweight ceramics, and semiconductor design. To date, however, the molecular and biochemical events controlling coccolith production have not been determined. In addition, little is known about the life cycle of E. huxleyi and the environmental and physiological signals triggering phase switching between the diploid and haploid life cycle stages. We have developed laboratory methods for inducing phase variation between the haploid (S-cell) and diploid (C-cell) life cycle stages of E. huxleyi. Plating E. huxleyi C cells on solid media was shown to induce phase switching from the C-cell to the S-cell life cycle stage, the latter of which has been maintained for over 2 years under these conditions. Pure cultures of S cells were obtained for the first time. Laboratory conditions for inducing phase switching from the haploid stage to the diploid stage were also established. Regeneration of the C-cell stage from pure cultures of S cells followed a predictable pattern involving formation of large aggregations of S cells and the subsequent production of cultures consisting predominantly of diploid C cells. These results demonstrate the ability to manipulate the life cycle of E. huxleyi under controlled laboratory conditions, providing us with powerful tools for the development of genetic techniques for analysis of coccolithogenesis and for investigating the complex life cycle of this important marine alga. PMID:11525973

Taking Another Look at the Data Management Life Cycle: Deconstruction, Agile, and Community

NASA Astrophysics Data System (ADS)

Young, J. W.; Lenhardt, W. C.; Parsons, M. A.; Benedict, K. K.

2014-12-01

The data life cycle has figured prominently in describing the context of digital scientific data stewardship and cyberinfractructure in support of science. There are many different versions of the data life cycle, but they all follow a similar basic pattern: plan, collect, ingest, asses, preserve, discover, and reuse. The process is often interpreted in a fairly linear fashion despite it being a cycle conceptually. More recently at GeoData 2014 and elsewhere, questions have been raised about the utility of the data life cycle as it is currently represented. We are proposing to the community a re-examination of the data life cycle using an agile lens. Our goal is not to deploy agile methods, but to use agile principles as a heuristic to think about how to incorporate data stewardship across the scientific process from proposal stage to research and beyond. We will present alternative conceptualizations of the data life cycle with a goal to solicit feedback and to develop a new model for conceiving and describing the overall data stewardship process. We seek to re-examine past assumptions and shed new light on the challenges and necessity of data stewardship. The ultimate goal is to support new science through enhanced data interoperability, usability, and preservation.

Thermal barrier coating life-prediction model development

NASA Technical Reports Server (NTRS)

Strangman, T. E.; Neumann, J.

1985-01-01

Life predictions are made for two types of strain-tolerant and oxidation-resistant Thermal Barrier Coating (TBC) systems produced by commercial coating suppliers to the gas turbine industry. The plasma-sprayed TBC system, composed of a low-pressure plasma spray (LPPS) applied oxidation-resistant NiCrAlY bond coating and an air-plasma-sprayed yttria (8 percent) partially stabilized zirconia insulative layer, is applied by both Chromalloy and Klock. The second type of TBC is applied by the electron-beam/physical vapor deposition process by Temescal. Thermomechanical and thermochemical testing of the program TBCs is in progress. A number of the former tests has been completed. Fracture mechanics data for the Chromalloy plasma-sprayed TBC system indicate that the cohesive toughness of the zirconia layer is increased by thermal cycling and reduced by high temperature exposure at 1150 C. Eddy current technology feasibility has been established with respect to nondestructively measuring zirconia layer thickness of a TBC system. High pressure turbine blades have been coated with program TBC systems for a piggyback test in a TFE731-5 turbofan factory engine test. Data from this test will be used to validate the TBC life models.

Life cycles of traumatized teeth: long-term observations from a cohort of dental trauma victims.

PubMed

Heithersay, G S

2016-03-01

Life cycles of dental trauma victims can provide important clinical information, especially when viewed over many years. In this first series of life cycles, the pulp and periodontal responses to traumatic injuries of four patients are documented over periods varying from 26 to 51 years. The dynamics of pulp survival following an intrusive luxation and two avulsions are followed, with particular reference to pulp canal calcification to which a new term, root canal stenosis, has been proposed. The life cycles include the successful management of inflammatory root resorption in a replanted tooth with an open apex contrasting with the early prophylactic endodontic treatment of two replanted teeth in a patient with mature apices. The long-term development of invasive cervical resorption in one of the patient's life cycle highlights the importance of ongoing follow-up examinations for dental trauma victims. © 2016 Australian Dental Association.

Integrative Application of Life Cycle Assessment and Risk Assessment to Environmental Impacts of Anthropogenic Pollutants at a Watershed Scale.

PubMed

Lin, Xiaodan; Yu, Shen; Ma, Hwongwen

2018-01-01

Intense human activities have led to increasing deterioration of the watershed environment via pollutant discharge, which threatens human health and ecosystem function. To meet a need of comprehensive environmental impact/risk assessment for sustainable watershed development, a biogeochemical process-based life cycle assessment and risk assessment (RA) integration for pollutants aided by geographic information system is proposed in this study. The integration is to frame a conceptual protocol of "watershed life cycle assessment (WLCA) for pollutants". The proposed WLCA protocol consists of (1) geographic and environmental characterization mapping; (2) life cycle inventory analysis; (3) integration of life-cycle impact assessment (LCIA) with RA via characterization factor of pollutant of interest; and (4) result analysis and interpretation. The WLCA protocol can visualize results of LCIA and RA spatially for the pollutants of interest, which might be useful for decision or policy makers for mitigating impacts of watershed development.

Educational inequalities in smoking over the life cycle: an analysis by cohort and gender.

PubMed

Bricard, Damien; Jusot, Florence; Beck, François; Khlat, Myriam; Legleye, Stéphane

2016-01-01

The study investigates the life cycle patterns of educational inequalities in smoking according to gender over three successive generations. Based on retrospective smoking histories collected by the nationwide French Health Barometer survey 2010, we explored educational inequalities in smoking at each age, using the relative index of inequality. Educational inequalities in smoking increase across cohorts for men and women, corresponding to a decline in smoking among the highly educated alongside progression among the lower educated. The analysis also shows a life cycle evolution: for all cohorts and for men and women, inequalities are considerable during adolescence, then start declining from 18 years until the age of peak prevalence (around 25), after which they remain stable throughout the life cycle, even tending to rise for the most recent cohort. This analysis contributes to the description of the "smoking epidemic" and highlights adolescence and late adulthood as life cycle stages with greater inequalities.

Design for life-cycle profit with simultaneous consideration of initial manufacturing and end-of-life remanufacturing

NASA Astrophysics Data System (ADS)

Kwak, Minjung; Kim, Harrison

2015-01-01

Remanufacturing is emerging as a promising solution for achieving green, profitable businesses. This article considers a manufacturer that produces new products and also remanufactured versions of the new products that become available at the end of their life cycle. For such a manufacturer, design decisions at the initial design stage determine both the current profit from manufacturing and future profit from remanufacturing. To maximize the total profit, design decisions must carefully consider both ends of product life cycle, i.e. manufacturing and end-of-life stages. This article proposes a decision-support model for the life-cycle design using mixed-integer nonlinear programming. With an aim to maximize the total life-cycle profit, the proposed model searches for an (at least locally) optimal product design (i.e. design specifications and the selling price) for the new and remanufactured products. It optimizes both the initial design and design upgrades at the end-of-life stage and also provides corresponding production strategies, including production quantities and take-back rate. The model is extended to a multi-objective model that maximizes both economic profit and environmental-impact saving. To illustrate, the developed model is demonstrated with an example of a desktop computer.

Early-Life Origins of Life-Cycle Well-Being: Research and Policy Implications

ERIC Educational Resources Information Center

Currie, Janet; Rossin-Slater, Maya

2015-01-01

Mounting evidence across different disciplines suggests that early-life conditions can have consequences on individual outcomes throughout the life cycle. Relative to other developed countries, the United States fares poorly on standard indicators of early-life health, and this disadvantage may have profound consequences not only for population…

All about Animal Life Cycles. Animal Life for Children. [Videotape].

ERIC Educational Resources Information Center

2000

While watching the development from tadpole to frog, caterpillar to butterfly, and pup to wolf, children learn about the life cycles of animals, the different stages of development, and the average life spans of a variety of creatures. This videotape correlates to the following National Science Education Standards for Life Science: characteristics…

Model of human immunodeficiency virus budding and self-assembly: Role of the cell membrane

NASA Astrophysics Data System (ADS)

Zhang, Rui; Nguyen, Toan T.

2008-11-01

Budding from the plasma membrane of the host cell is an indispensable step in the life cycle of the human immunodeficiency virus (HIV), which belongs to a large family of enveloped RNA viruses, retroviruses. Unlike regular enveloped viruses, retrovirus budding happens concurrently with the self-assembly of the main retrovirus protein subunits (called Gag protein after the name of the genetic material that codes for this protein: Group-specific AntiGen) into spherical virus capsids on the cell membrane. Led by this unique budding and assembly mechanism, we study the free energy profile of retrovirus budding, taking into account the Gag-Gag attraction energy and the membrane elastic energy. We find that if the Gag-Gag attraction is strong, budding always proceeds to completion. During early stage of budding, the zenith angle of partial budded capsids, α , increases with time as α∝t1/2 . However, if the Gag-Gag attraction is weak, a metastable state of partial budding appears. The zenith angle of these partially spherical capsids is given by α0≃(τ2/κσ)1/4 in a linear approximation, where κ and σ are the bending modulus and the surface tension of the membrane, and τ is a line tension of the capsid proportional to the strength of Gag-Gag attraction. Numerically, we find α0<0.3π without any approximations. Using experimental parameters, we show that HIV budding and assembly always proceed to completion in normal biological conditions. On the other hand, by changing Gag-Gag interaction strength or membrane rigidity, it is relatively easy to tune it back and forth between complete budding and partial budding. Our model agrees reasonably well with experiments observing partial budding of retroviruses including HIV.

Planning for Cost Effectiveness.

ERIC Educational Resources Information Center

Schlaebitz, William D.

1984-01-01

A heat pump life-cycle cost analysis is used to explain the technique. Items suggested for the life-cycle analysis approach include lighting, longer-life batteries, site maintenance, and retaining experts to inspect specific building components. (MLF)

Deciphering life history transcriptomes in different environments

PubMed Central

Etges, William J.; Trotter, Meredith V.; de Oliveira, Cássia C.; Rajpurohit, Subhash; Gibbs, Allen G.; Tuljapurkar, Shripad

2014-01-01

We compared whole transcriptome variation in six preadult stages and seven adult female ages in two populations of cactophilic Drosophila mojavensis reared on two host plants in order to understand how differences in gene expression influence standing life history variation. We used Singular Value Decomposition (SVD) to identify dominant trajectories of life cycle gene expression variation, performed pair-wise comparisons of stage and age differences in gene expression across the life cycle, identified when genes exhibited maximum levels of life cycle gene expression, and assessed population and host cactus effects on gene expression. Life cycle SVD analysis returned four significant components of transcriptional variation, revealing functional enrichment of genes responsible for growth, metabolic function, sensory perception, neural function, translation and aging. Host cactus effects on female gene expression revealed population and stage specific differences, including significant host plant effects on larval metabolism and development, as well as adult neurotransmitter binding and courtship behavior gene expression levels. In 3 - 6 day old virgin females, significant up-regulation of genes associated with meiosis and oogenesis was accompanied by down-regulation of genes associated with somatic maintenance, evidence for a life history tradeoff. The transcriptome of D. mojavensis reared in natural environments throughout its life cycle revealed core developmental transitions and genome wide influences on life history variation in natural populations. PMID:25442828

A Life Cycle Assessment Framework for Pavement Maintenance and Rehabilitation Technologies : or An Integrated Life Cycle Assessment (LCA) – Life Cycle Cost Analysis (LCCA) Framework for Pavement Maintenance and Rehabilitation

DOT National Transportation Integrated Search

2018-02-01

Qing Lu (ORCID ID 0000-0002-9120-9218) Given a huge amount of annual investment and large inputs of energy and natural resources in pavement maintenance and rehabilitation (M&R) activities, significant environmental improvement and budget saving can ...

Using Screening Level Environmental Life Cycle Assessment to Aid Decision Making: A Case Study of a College Annual Report

ERIC Educational Resources Information Center

Ingwersen, Wesley W.; Curran, Mary Ann; Gonzalez, Michael A.; Hawkins, Troy R.

2012-01-01

Purpose: The purpose of this study is to compare the life cycle environmental impacts of the University of Cincinnati College of Engineering and Applied Sciences' current printed annual report to a version distributed via the internet. Design/methodology/approach: Life cycle environmental impacts of both versions of the report are modeled using…

Life-Cycle Thinking in Inquiry-Based Sustainability Education--Effects on Students' Attitudes towards Chemistry and Environmental Literacy

ERIC Educational Resources Information Center

Juntunen, Marianne; Aksela, Maija

2013-01-01

The aim of the present study is to improve the quality of students' environmental literacy and sustainability education in chemistry teaching by combining the socio-scientific issue of life-cycle thinking with inquiry-based learning approaches. This case study presents results from an inquiry-based life-cycle thinking project: an interdisciplinary…

Navy Program Manager’s Guide, 1985 Edition

DTIC Science & Technology

1985-01-01

1-7 Relationship of Development Cost in System Life -Cycle Cost (LCC) ......................... 1-7 Realistic Costing and Budgeting...Review (PROR)..... 4-53 x MI *) First-Article Configuration Inspection (FACI) ...... 4-54 Cost Management- Life -Cycle Costing (LCC) ..................... 4...innovation and minimize costs. 4. Consideration of life -cycle cost (LCC) such that affordability is put on an equal basis with system performance, schedule

Cradle to Gate Life Cycle Assessment of Softwood Lumber Production from the Northeast-North Central

Treesearch

Maureen Puettmann; Elaine Oneil; Richard Bergman

2013-01-01

CORRIM, the Consortium for Research on Renewable Industrial Materials, has derived life cycle inventory (LCI) data for major wood products and wood production regions in the United States. The life cycle inventory data cover from forest regeneration through to final product at the mill gate. Research has covered nine major forest products including both structural and...

The observed life cycle of a baroclinic instability

NASA Technical Reports Server (NTRS)

Randel, W. J.; Stanford, J. L.

1985-01-01

Medium-scale waves (zonal wavenumbers 4-7) frequently dominate Southern Hemisphere summer circulation patterns. Randel and Stanford have studied the dynamics of these features, demonstrating that the medium-scale waves result from baroclinic excitation and exhibit well-defined life cycles. This study details the evolution of the medium-scale waves during a particular life cycle. The specific case chosen exhibits a high degree of zonal symmetry, prompting study based upon zonally averaged diagnostics. An analysis of the medium-scale wave energetics reveals a well-defined life cycle of baroclinic growth, maturity, and barotropic decay. Eliassen-Palm flux diagrams detail the daily wave structure and its interaction with the zonally-averaged flow.

Hot fire test results of subscale tubular combustion chambers

NASA Technical Reports Server (NTRS)

Kazaroff, John M.; Jankovsky, Robert S.; Pavli, Albert J.

1992-01-01

Advanced, subscale, tubular combustion chambers were built and test fired with hydrogen-oxygen propellants to assess the increase in fatigue life that can be obtained with this type of construction. Two chambers were tested: one ran for 637 cycles without failing, compared to a predicted life of 200 cycles for a comparable smooth-wall milled-channel liner configuration. The other chamber failed at 256 cycles, compared to a predicted life of 118 cycles for a comparable smooth-wall milled-channel liner configuration. Posttest metallographic analysis determined that the strain-relieving design (structural compliance) of the tubular configuration was the cause of this increase in life.

A life cycle model of public policy issues in health care: the importance of strategic issues management.

PubMed

Rakich, J S; Feit, M D

2001-01-01

Public policy affects health and social services organizations. Senior management has a responsibility to prevent inappropriate demands of stakeholders from predominating and to influence the outcome of public policy to the benefit of their organization through the strategic issues management process. This article presents a public policy issue life cycle model, life-cycle stages and suggested strategies, paths issues can take in the life cycle, and factors that affect issue paths. An understanding of these dynamics can aid senior managers in shaping and changing public policy issues and lessening external environment threats to their organization.

Recurrent bottlenecks in the malaria life cycle obscure signals of positive selection.

PubMed

Chang, Hsiao-Han; Hartl, Daniel L

2015-02-01

Detecting signals of selection in the genome of malaria parasites is a key to identify targets for drug and vaccine development. Malaria parasites have a unique life cycle alternating between vector and host organism with a population bottleneck at each transition. These recurrent bottlenecks could influence the patterns of genetic diversity and the power of existing population genetic tools to identify sites under positive selection. We therefore simulated the site-frequency spectrum of a beneficial mutant allele through time under the malaria life cycle. We investigated the power of current population genetic methods to detect positive selection based on the site-frequency spectrum as well as temporal changes in allele frequency. We found that a within-host selective advantage is difficult to detect using these methods. Although a between-host transmission advantage could be detected, the power is decreased when compared with the classical Wright-Fisher (WF) population model. Using an adjusted null site-frequency spectrum that takes the malaria life cycle into account, the power of tests based on the site-frequency spectrum to detect positive selection is greatly improved. Our study demonstrates the importance of considering the life cycle in genetic analysis, especially in parasites with complex life cycles.

The phylogeny and life cycle of two species of Profilicollis (Acanthocephala: Polymorphidae) in marine hosts off the Pacific coast of Chile.

PubMed

Rodríguez, S M; D'Elía, G; Valdivia, N

2017-09-01

Resolving complex life cycles of parasites is a major goal of parasitological research. The aim of this study was to analyse the life cycle of two species of the genus Profilicollis, the taxonomy of which is still unstable and life cycles unclear. We extracted individuals of Profilicollis from two species of crustaceans (intermediate hosts) and four species of seagulls (definitive hosts) from sandy-shore and estuarine habitats along the south-east Pacific coast of Chile. Mitochondrial DNA analyses showed that two species of Profilicollis infected intermediate hosts from segregated habitats: while P. altmani larvae infected exclusively molecrabs of the genus Emerita from fully marine habitats, P. antarcticus larvae infected the crab Hemigrapsus crenulatus from estuarine habitats. Moreover, P. altmani completed its life cycle in four seagulls, Chroicocephalus maculipennis, Leucopheus pipixcan, Larus modestus and L. dominicanus, while P. antarcticus, on the other hand, completed its life cycle in the kelp gull L. dominicanus. Accordingly, our results show that two congeneric parasites use different and spatially segregated species as intermediate hosts, and both are capable of infecting one species of definitive hosts. As such, our analyses allow us to shed light on a complex interaction network.

Evaluation of Cycle Life and Characterization of YTP 45 Ah Li-Ion Battery for EMU

NASA Technical Reports Server (NTRS)

Deng, Yi; Jeevarajan, Judith; Rehm, Raymond; Bragg, Bobby; Strangways, Brad

2002-01-01

Li-ion batteries, with longer cycle life and higher energy density features, are now more and more attractive and applied in multiple fields. The YTP 45 Ah Li-ion battery has been evaluated here and may be employed in EMU in the future. Evaluations were on: (1) Cycle life tests - 500 cycles total (completed 40 cycles in simulated shuttle use mode and 460 cycles in an accelerated use mode, and recorded differential voltage of individual cell in battery); (2) Characterization test - discharge capacity measurement in environment temperature of -10, 25, 50 C before and after 500 cycles; and (3) Thermal testing - charge and discharge at 50 C and -10 C before and after 500 cycles. The battery showed less than a 9% drop of initial discharge capacity and energy within 500 cycles with 475 cycles 59% DOD plus 25 cycles 100% DOD. The EOD voltage ranged from 16.0 to 18.0 V, which fits the requirement for operating the EMU.

Characterization and comprehension of corona partial discharge in air under power frequency to very low frequency voltage

NASA Astrophysics Data System (ADS)

Yuanxiang, ZHOU; Zhongliu, ZHOU; Ling, ZHANG; Yunxiao, ZHANG; Yajun, MO; Jiantao, SUN

2018-05-01

For the partial discharge test of electrical equipment with large capacitance, the use of low-frequency voltage instead of power frequency voltage can effectively reduce the capacity requirements of test power supply. However, the validity of PD test under low frequency voltage needs to be evaluated. In order to investigate the influence of voltage frequency on corona discharge in the air, the discharge test of the tip-plate electrode under the frequency from 50 to 0.1 Hz is carried out based on the impulse current method. The results show that some of the main features of corona under low frequency do not change. The magnitude of discharge in a positive half cycle is obviously larger than that in a negative cycle. The magnitude of discharge and interval in positive cycle are random, while that in negative cycle are regular. With the decrease of frequency, the inception voltage increases. The variation trend of maximum and average magnitude and repetition rate of the discharge in positive and negative half cycle with the variation of voltage frequency and magnitude is demonstrated, with discussion and interpretation from the aspects of space charge transportation, effective discharge time and transition of discharge modes. There is an obvious difference in the phase resolved pattern of partial discharge and characteristic parameters of discharge patterns between power and low frequency. The experimental results can be the reference for mode identification of partial discharge under low frequency tests. The trend of the measured parameters with the variation of frequency provides more information about the insulation defect than traditional measurements under a single frequency (usually 50 Hz). Also it helps to understand the mechanism of corona discharge with an explanation of the characteristics under different frequencies.

Insight into the role of cetaceans in the life cycle of the tetraphyllideans (Platyhelminthes: Cestoda).

PubMed

Aznar, F J; Agustí, C; Littlewood, D T J; Raga, J A; Olson, P D

2007-02-01

Four types of tetraphyllidean larvae infect cetaceans worldwide: two plerocercoids differing in size, 'small' (SP) and 'large' (LP), and two merocercoids referred to as Phyllobothrium delphini and Monorygma grimaldii. The latter merocercoid larvae parasitize marine mammals exclusively and exhibit a specialised cystic structure. Adult stages are unknown for any of the larvae and thus the role of cetaceans in the life cycle of these species has been a long-standing problem. The SP and LP forms are thought to be earlier stages of P. delphini and M. grimaldii that are presumed to infect large pelagic sharks that feed on cetaceans. A molecular analysis of the D2 variable region of the large subunit ribosomal DNA gene based on several individuals of each larval type collected from three Mediterranean species of cetaceans showed consistent and unique molecular signatures for each type regardless of host species or site of infection. The degree of divergence suggested that LP, P. delphini and M. grimaldii larvae may represent separate species, whereas SP may be conspecific with M. grimaldii. In all host species, individuals of SP accumulated in the gut areas in which the lymphoid tissue was especially developed. We suggest therefore that these larvae use the lymphatic system to migrate to the abdominal peritoneum and mesenteries where they develop into forms recognizable as M. grimaldii. The plerocercoid stage of P. delphini remains unknown. In a partial phylogenetic tree of the Tetraphyllidea, all larvae formed a clade that included a representative of the genus Clistobothrium, some species of which parasitize sharks such as the great white which is known to feed on cetaceans. A bibliographic examination of tetraphyllidean infections in marine mammals indicated that these larvae are acquired mostly offshore. In summary, the evidence suggests that cetaceans play a significant role in the life cycle of these larvae. In addition, it seems clear that cetaceans act as natural intermediate hosts for P. delphini and M. grimaldii, as within these hosts they undergo development from the plerocercoid stage to the merocercoid stage. Because tetraphyllidean species use fish, cephalopods and other marine invertebrates as intermediate hosts, the inclusion of cetaceans in the life cycle would have facilitated their transmission to apex predators such as the large, lamnid sharks. The biological significance of infections of LP in cetaceans is unclear, but infections do not seem to be accidental as such larvae show high prevalence and abundance as well as a high degree of site specificity, particularly in the anal crypts and bile ducts.

Hybrid lithium-ion capacitor with LiFePO4/AC composite cathode - Long term cycle life study, rate effect and charge sharing analysis

NASA Astrophysics Data System (ADS)

Shellikeri, A.; Yturriaga, S.; Zheng, J. S.; Cao, W.; Hagen, M.; Read, J. A.; Jow, T. R.; Zheng, J. P.

2018-07-01

Energy storage devices, which can combine the advantages of lithium-ion battery with that of electric double layer capacitor, are of prime interest. Recently, composite cathodes, which combine a battery material with capacitor material, have shown promise in enhancing life cycle and energy/power performances. Lithium-ion capacitor (LIC), with unique charge storage mechanism of combining a pre-lithiated battery anode with a capacitor cathode, is one such device which has the potential to synergistically incorporate the composite cathode to enhance capacity and cycle life. We report here a hybrid LIC consisting of a lithium iron phosphate (LiFePO4-LFP)/Activated Carbon composite cathode in combination with a hard carbon anode, by integrating the cycle life and capacity enhancing strategies of a dry method of electrode fabrication, anode pre-lithiation and a 3:1 anode to cathode capacity ratio, demonstrating a long cycle life, while elaborating on the charge sharing between the faradaic and non-faradaic mechanism in the battery and capacitor materials, respectively in the composite cathode. An excellent cell capacity retention of 94% (1000 cycles at 1C) and 92% (100,000 cycles at 60C) were demonstrated, while retaining 78% (over 6000 cycles at 2.7C) and 67% (over 70,000 cycles at 43C) of the LFP capacity in the composite cathode.

78 FR 47235 - Airworthiness Directives; General Electric Company Turbofan Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... revenue flight cycles. These parts were then installed into engines and introduced into revenue service... cycle counts of those LLPs to account for the additional low cycle fatigue (LCF) life consumed during... Boeing 747-8 flight tests had consumed more cyclic life than they would have in revenue flight cycles...

Life Cycle Costing.

ERIC Educational Resources Information Center

McCraley, Thomas L.

1985-01-01

Life cycle costing establishes a realistic comparison of the cost of owning and operating products. The formula of initial cost plus maintenance plus operation divided by useful life identifies the best price over the lifetime of the product purchased. (MLF)

Independent divergence of 13- and 17-y life cycles among three periodical cicada lineages.

PubMed

Sota, Teiji; Yamamoto, Satoshi; Cooley, John R; Hill, Kathy B R; Simon, Chris; Yoshimura, Jin

2013-04-23

The evolution of 13- and 17-y periodical cicadas (Magicicada) is enigmatic because at any given location, up to three distinct species groups (Decim, Cassini, Decula) with synchronized life cycles are involved. Each species group is divided into one 13- and one 17-y species with the exception of the Decim group, which contains two 13-y species-13-y species are Magicicada tredecim, Magicicada neotredecim, Magicicada tredecassini, and Magicicada tredecula; and 17-y species are Magicicada septendecim, Magicicada cassini, and Magicicada septendecula. Here we show that the divergence leading to the present 13- and 17-y populations differs considerably among the species groups despite the fact that each group exhibits strikingly similar phylogeographic patterning. The earliest divergence of extant lineages occurred ∼4 Mya with one branch forming the Decim species group and the other subsequently splitting 2.5 Mya to form the Cassini and Decula species groups. The earliest split of extant lineages into 13- and 17-y life cycles occurred in the Decim lineage 0.5 Mya. All three species groups experienced at least one episode of life cycle divergence since the last glacial maximum. We hypothesize that despite independent origins, the three species groups achieved their current overlapping distributions because life-cycle synchronization of invading congeners to a dominant resident population enabled escape from predation and population persistence. The repeated life-cycle divergences supported by our data suggest the presence of a common genetic basis for the two life cycles in the three species groups.

An Integrated Approach to Life Cycle Analysis

NASA Technical Reports Server (NTRS)

Chytka, T. M.; Brown, R. W.; Shih, A. T.; Reeves, J. D.; Dempsey, J. A.

2006-01-01

Life Cycle Analysis (LCA) is the evaluation of the impacts that design decisions have on a system and provides a framework for identifying and evaluating design benefits and burdens associated with the life cycles of space transportation systems from a "cradle-to-grave" approach. Sometimes called life cycle assessment, life cycle approach, or "cradle to grave analysis", it represents a rapidly emerging family of tools and techniques designed to be a decision support methodology and aid in the development of sustainable systems. The implementation of a Life Cycle Analysis can vary and may take many forms; from global system-level uncertainty-centered analysis to the assessment of individualized discriminatory metrics. This paper will focus on a proven LCA methodology developed by the Systems Analysis and Concepts Directorate (SACD) at NASA Langley Research Center to quantify and assess key LCA discriminatory metrics, in particular affordability, reliability, maintainability, and operability. This paper will address issues inherent in Life Cycle Analysis including direct impacts, such as system development cost and crew safety, as well as indirect impacts, which often take the form of coupled metrics (i.e., the cost of system unreliability). Since LCA deals with the analysis of space vehicle system conceptual designs, it is imperative to stress that the goal of LCA is not to arrive at the answer but, rather, to provide important inputs to a broader strategic planning process, allowing the managers to make risk-informed decisions, and increase the likelihood of meeting mission success criteria.

Animal Life Cycles. Animal Life in Action[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

This 23-minute videotape for grades 5-8, presents the myriad of animal life that exists on the planet. Students can view and perform experiments and investigations that help explain animal traits and habits. The stages of life that animals pass through--birth, growth, maturation, reproduction, and death--make up the life cycle. Students learn…

Multiaxial Fatigue Damage Parameter and Life Prediction without Any Additional Material Constants

PubMed Central

Yu, Zheng-Yong; Liu, Qiang; Liu, Yunhan

2017-01-01

Based on the critical plane approach, a simple and efficient multiaxial fatigue damage parameter with no additional material constants is proposed for life prediction under uniaxial/multiaxial proportional and/or non-proportional loadings for titanium alloy TC4 and nickel-based superalloy GH4169. Moreover, two modified Ince-Glinka fatigue damage parameters are put forward and evaluated under different load paths. Results show that the generalized strain amplitude model provides less accurate life predictions in the high cycle life regime and is better for life prediction in the low cycle life regime; however, the generalized strain energy model is relatively better for high cycle life prediction and is conservative for low cycle life prediction under multiaxial loadings. In addition, the Fatemi–Socie model is introduced for model comparison and its additional material parameter k is found to not be a constant and its usage is discussed. Finally, model comparison and prediction error analysis are used to illustrate the superiority of the proposed damage parameter in multiaxial fatigue life prediction of the two aviation alloys under various loadings. PMID:28792487

Multiaxial Fatigue Damage Parameter and Life Prediction without Any Additional Material Constants.

PubMed

Yu, Zheng-Yong; Zhu, Shun-Peng; Liu, Qiang; Liu, Yunhan

2017-08-09

Based on the critical plane approach, a simple and efficient multiaxial fatigue damage parameter with no additional material constants is proposed for life prediction under uniaxial/multiaxial proportional and/or non-proportional loadings for titanium alloy TC4 and nickel-based superalloy GH4169. Moreover, two modified Ince-Glinka fatigue damage parameters are put forward and evaluated under different load paths. Results show that the generalized strain amplitude model provides less accurate life predictions in the high cycle life regime and is better for life prediction in the low cycle life regime; however, the generalized strain energy model is relatively better for high cycle life prediction and is conservative for low cycle life prediction under multiaxial loadings. In addition, the Fatemi-Socie model is introduced for model comparison and its additional material parameter k is found to not be a constant and its usage is discussed. Finally, model comparison and prediction error analysis are used to illustrate the superiority of the proposed damage parameter in multiaxial fatigue life prediction of the two aviation alloys under various loadings.

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight battery cells

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1990-01-01

A breakthrough in low earth orbit (LEO) cycle life of individual pressure vessel (IPV) nickel hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26 percent potassium hydroxide (KOH) electrolyte was about 40,000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH. The effect of KOH concentration on cycle life was studied. The cycle regime was a stressful accelerated LEO, which consisted of a 27.5 min charge followed by a 17.5 min charge (2 x normal rate). The depth of discharge (DOD) was 80 percent. The cell temperature was maintained at 23 C. The next step is to validate these results using flight hardware and a real time LEO test. NASA Lewis has a contract with the Naval Weapons Support Center (NWSC), Crane, Indiana, to validate the boiler plate test results. Six 48 A-hr Hughes recirculation design IPV nickel-hydrogen flight battery cells are being evaluated. Three of the cells contain 26 percent KOH (test cells) and three contain 31 percent KOH (control cells). They are undergoing real time LEO cycle life testing. The cycle regime is a 90-min LEO orbit consisting of a 54-min charge followed by a 36-min discharge. The depth-of-discharge is 80 percent. The cell temperature is maintained at 10 C. The cells were cycled for over 8000 cycles in the continuing test. There were no failures for the cells containing 26 percent KOH. There was two failures, however, for the cells containing 31 percent KOH.

Effect of KOH concentration on LEO cycle life of IPV nickel-hydrogen flight battery cells

NASA Technical Reports Server (NTRS)

Smithrick, John J.; Hall, Stephen W.

1990-01-01

A breakthrough in the low-earth-orbit (LEO) cycle life of individual pressure vessel (IPV) nickel hydrogen battery cells is reported. The cycle life of boiler plate cells containing 26 percent potassium hydroxide (KOH) electrolyte was about 40,000 LEO cycles compared to 3500 cycles for cells containing 31 percent KOH. The effect of KOH concentration on cycle life was studied. The cycle regime was a stressful accelerated LEO, which consisted of a 27.5 min charge followed by a 17.5 min charge (2 x normal rate). The depth of discharge (DOD) was 80 percent. The cell temperature was maintained at 23 C. The next step is to validate these results using flight hardware and real time LEO test. NASA Lewis has a contract with the Naval Weapons Support Center (NWSC), Crane, Indiana to validate the boiler plate test results. Six 48 A-hr Hughes recirculation design IPV nickel-hydrogen flight battery cells are being evaluated. Three of the cells contain 26 percent KOH (test cells) and three contain 31 percent KOH (control cells). They are undergoing real time LEO cycle life testing. The cycle regime is a 90-min LEO orbit consisting of a 54-min charge followed by a 36-min discharge. The depth-of-discharge is 80 percent. The cell temperature is maintained at 10 C. The cells were cycled for over 8000 cycles in the continuing test. There were no failures for the cells containing 26 percent KOH. There were two failures, however, for the cells containing 31 percent KOH.

A Comparative Analysis of Life-Cycle Assessment Tools for End-of-Life Materials Management Systems

EPA Science Inventory

We identified and evaluated five life-cycle assessment tools that community decision makers can use to assess the environmental and economic impacts of end-of-life (EOL) materials management options. The tools evaluated in this report are waste reduction mode (WARM), municipal s...

Life Cycle. K-6 Science Curriculum.

ERIC Educational Resources Information Center

Blueford, J. R.; And Others

Life Cycle is one of the units of a K-6 unified science curriculum program. The unit consists of four organizing sub-themes: (1) past life (focusing on dinosaurs and fossil formation, types, and importance); (2) animal life (examining groups of invertebrates and vertebrates, cells, reproduction, and classification systems); (3) plant life…

The life cycle of a tornadic cloud as seen from a geosynchronous satellite

NASA Technical Reports Server (NTRS)

Hung, R. J.; Dodge, J. C.; Smith, R. E.

1983-01-01

The life span of a severe storm is on the order of a few hours. Rapid-scan infrared and visible observations from geosynchronous satellites can be useful for studying the life cycle of a severe convective storm. By using artificial colors for pixels representing blackbody temperatures of the cloud top, convective storms can be observed throughout their life cycles. In this paper clouds associated with a tornadic storm, the Ringwood, OK tornado on May 29, 1977, are compared with those without a tornadic storm to illustrate how the infrared and visible observations from a geosynchronous satellite can be used to study the differences in their life cycles. The instability of the air mass and the meteorological background are discussed based on balloon observations.

Digital Avionics Information System (DAIS): Life Cycle Cost Impact Modeling System (LCCIM)--A Managerial Overview. Final Report.

ERIC Educational Resources Information Center

Goclowski, John C.; Baran, H. Anthony

This report gives a managerial overview of the Life Cycle Cost Impact Modeling System (LCCIM), which was designed to provide the Air Force with an in-house capability of assessing the life cycle cost impact of weapon system design alternatives. LCCIM consists of computer programs and the analyses which the user must perform to generate input data.…

Addressing software security risk mitigations in the life cycle

NASA Technical Reports Server (NTRS)

Gilliam, David; Powell, John; Haugh, Eric; Bishop, Matt

2003-01-01

The NASA Office of Safety and Mission Assurance (OSMA) has funded the Jet Propulsion Laboratory (JPL) with a Center Initiative, 'Reducing Software Security Risk through an Integrated Approach' (RSSR), to address this need. The Initiative is a formal approach to addressing software security in the life cycle through the instantiation of a Software Security Assessment Instrument (SSAI) for the development and maintenance life cycles.

Life-cycle assessment of redwood decking in the United States with a comparison to three other decking materials

Treesearch

R. Bergman; H. Sup-Han; E. Oneil; I. Eastin

2013-01-01

The goal of the study was to conduct a life-cycle inventory (LCI) of California redwood (Sequoia sempervirens) decking that would quantify the critical environmental impacts of decking from cradle to grave. Using that LCI data, a life-cycle assessment (LCA) was produced for redwood decking. The results were used to compare the environmental footprint...

A Life-Cycle Assessment of Biofuels: Tracing Energy and Carbon through a Fuel-Production System

ERIC Educational Resources Information Center

Krauskopf, Sara

2010-01-01

A life-cycle assessment (LCA) is a tool used by engineers to make measurements of net energy, greenhouse gas production, water consumption, and other items of concern. This article describes an activity designed to walk students through the qualitative part of an LCA. It asks them to consider the life-cycle costs of ethanol production, in terms of…

Family Decisionmaking Over the Life Cycle: Some Implications for Estimating the Effects of Income Maintenance Programs.

ERIC Educational Resources Information Center

Smith, James P.

The standard one-period labor supply model that economists have used is in some ways an inadequate tool to evaluate a Family Assistance Plan (FAP). The principal difficulty is that an FAP will have important interperiod or life cycle effects. The pure life cycle model, an extension of the work of Becker and Ghez, is derived here without reference…

Building Information Modeling (BIM) Primer. Report 1: Facility Life-Cycle Process and Technology Innovation

DTIC Science & Technology

2012-08-01

Building Information Modeling ( BIM ) Primer Report 1: Facility Life-cycle Process and Technology Innovation In fo...is unlimited. ERDC/ITL TR-12-2 August 2012 Building Information Modeling ( BIM ) Primer Report 1: Facility Life-cycle Process and Technology...and to enhance the quality of projects through the design, construction, and handover phases. Building Information Modeling ( BIM ) is a

77 FR 33995 - Petition Filed by American Cable Association for Partial Reconsideration of the Commission's...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... Fifth Report and Order; Announces Schedule for Pleading Cycle AGENCY: Federal Communications Commission... Alert System (EAS) Fifth Report and Order, and announces a schedule for the pleading cycle. DATES... process last at least one year. By the Public Notice, the Commission establishes a pleading cycle for...

Tape recorder failure investigation

NASA Technical Reports Server (NTRS)

Higgins, M. D.; Loewenthal, S. H.; Carnahan, C. C.; Snyder, G. L.

1996-01-01

Two end-item tape recorders lost 4:1 mode data recording mode capability at less than half of their 1 6,000-cycle, 4-year operating life. Subsequent life tests on two spare recorders also experienced 4:1 mode data loss at 8,000 and 11,700 cycles. Tear down inspection after completion of the life tests showed that the tape had worn through the alfesil record and reproduce heads. An investigation was initiated to understand the cause of excessive tape head wear and the reasons why the 4:1 mode data rate, low-speed mode is more damaging than the 1:1 mode data rate, high-speed recording mode. The objective was to establish how operating conditions (tape speed, humidity, temperature, stop/start cycles) affects head life with the goal of extending head life on the remaining in-service tape recorders. Another interest was to explain why an earlier vendor life test showed capability beyond 16,000 cycles.

Grainex Mar-M 247 Turbine Disk Life Study for NASA's High Temperature High Speed Turbine Seal Test Facility

NASA Technical Reports Server (NTRS)

Delgado, Irebert R.

2015-01-01

An experimental and analytical fatigue life study was performed on the Grainex Mar-M 247 disk used in NASA s Turbine Seal Test Facility. To preclude fatigue cracks from growing to critical size in the NASA disk bolt holes due to cyclic loading at severe test conditions, a retirement-for-cause methodology was adopted to detect and monitor cracks within the bolt holes using eddy-current inspection. For the NASA disk material that was tested, the fatigue strain-life to crack initiation at a total strain of 0.5 percent, a minimum to maximum strain ratio of 0, and a bolt hole temperature of 649 C was calculated to be 665 cycles using -99.95 percent prediction intervals. The fatigue crack propagation life was calculated to be 367 cycles after implementing a safety factor of 2 on life. Thus, the NASA disk bolt hole total life or retirement life was determined to be 1032 cycles at a crack depth of 0.501 mm. An initial NASA disk bolt hole inspection at 665 cycles is suggested with 50 cycle inspection intervals thereafter to monitor fatigue crack growth.

Results of deep DoD life cycle tests at high rates on 12Ah NiCd cells

NASA Technical Reports Server (NTRS)

Panneton, Paul E.; Meyer, John R.

1992-01-01

A 12 Ah Nickel-Cadmium (NiCd) Low Earth Orbit (LEO) life cycle test that induced 47 percent more deep Depth Of Discharge cycles by mixing them with shallow DOD cycles is discussed. The test showed how aggressive recharging to a C/D ratio of 1.15 nearly doubled performance over cycling below a C/D of 1.11.

Life cycle strategies of copepods in coastal upwelling zones

NASA Astrophysics Data System (ADS)

Peterson, W.

1998-06-01

Life cycles of copepods of coastal upwelling zones are of the multigenerational type—as many as 10 or more generations may be produced each year, depending upon water temperature, food concentration and length of the upwelling season. Abundant food resources and moderate temperature convey advantages to those copepods living in coastal upwelling zones, however, there is a clear disadvantage in that coastal upwelling zones are highly advective environments. Typically, water circulation patterns are such that surface waters are carried offshore, deeper waters carried onshore and most of the water column over the continental shelf is moving equatorward. The challenge to copepod species that inhabit upwelling systems is life cycle closure—how do eggs, nauplii, juveniles and adults avoid being swept out of these ecosystems in the face of persistent transport out of the system? In this review, I first list the species which dominate coastal upwelling ecosystems then discuss three variations on the multigenerational life cycle scheme that are observed in upwelling systems. The latter part of the review is devoted to discussion of how individuals are retained in the productive continental shelf waters within coastal upwelling ecosystems. The suggestion is made that the only copepod species that successfully achieve life cycle closure in such systems are those that are preadapted to upwelling circulation patterns. Our quantitative understanding of the relative importance of physical factors (such as advection) and biological factors (birth, growth, and mortality) on life cycle strategies and population dynamics is quite rudimentary. It would help our understanding if there were more field studies and more computer modeling studies that focused on seasonal cycles of abundance, development times and vertical distribution of life cycle stages, and measurements of water circulation patterns.

Chopper-controlled discharge life cycling studies on lead-acid batteries

NASA Technical Reports Server (NTRS)

Kraml, J. J.; Ames, E. P.

1982-01-01

State-of-the-art 6 volt lead-acid golf car batteries were tested. A daily charge/discharge cycling to failure points under various chopper controlled pulsed dc and continuous current load conditions was undertaken. The cycle life and failure modes were investigated for depth of discharge, average current chopper frequency, and chopper duty cycle. It is shown that battery life is primarily and inversely related to depth of discharge and discharge current. Failure mode is characterized by a gradual capacity loss with consistent evidence of cell element aging.

Life Cycle Cost of C-130E Weapon System.

DTIC Science & Technology

1977-07-01

AFHRL-TR-7746 A-,I K lR FORCE g•r ___ FORCELIFE CYCLE COST OF C-130E WEAPON SYSTEM H By U Frank D. Brown "Gary A. WalkerU David H. WilsonBooing Awsp...I REPORT DOCUMENTO ON PAGE BEFORE COMPLETING FORM I?~ AFHR R.77-46 ( ~ LIFE CYCLE COST OF:C413A~ WEAPON SYSTEMteim.e M- 29 June 116- 3 June...human resources cost data life cycle cost historical weapon system analysis (I-WSA) inateuial resources 20). ABSTRACT (Con tinue on reverse siLa Mf

Low-Earth-Orbit (LEO) Life Cycle Evaluation of Nickel-Zinc Batteries

NASA Technical Reports Server (NTRS)

Coates, D.; Ferreira, E.; Nyce, M.; Charkey, A.

1997-01-01

The conclusion of the Low-Earth-Orbit (LEO) life cycle evaluation of nickel-zinc batteries are: that composite nickel electrode provide excellent performance at a reduced weight and lower cost; calcium / zinc electrode minimizes shape change; unioptimized cell designs yield 60 Wh/kg; nickel-zinc delivers 600 cycles at 80% DOD; long cycle life obtainable at low DOD; high rate capability power density; long-term failure mechanism is stack dry; and anomalous overcharge (1120%) greatly affected cell performance but did not induce failure and was recoverable.

Research on the application of BIM technology in the whole life cycle of construction projects

NASA Astrophysics Data System (ADS)

Chang-liu, CHEN; Wei-wei, KOU; Shuai-hua, YE

2018-05-01

BIM technology can realize information sharing, and good BIM application will reduce the whole life cycle cost of construction projects. The popularization of BIM technology challenges the application of BIM technology at all stages of the whole life cycle of the construction project. It will give full play to the value of BIM, if developing a reasonable BIM project execution plan, defining BIM requirements, specifying Level of Development, determining the BIM quality control plan and clearing BIM application content of each stage, and will provide a unified method for project stakeholders, realize the whole life cycle of construction projects, and achieve the desired information sharing in construction project.

Effects of arc current on the life in burner rig thermal cycling of plasma sprayed ZrOsub2-Ysub2Osub3

NASA Technical Reports Server (NTRS)

Hendricks, R. C.; Mcdonald, G.

1982-01-01

An analysis of thermal cycle life data for four sets of eight thermal barrier coated specimens representing arc currents (plasma gun power) of 525, 600, 800, or 950 amps is presented. The ZrO2-8Y2O3/NiCrAlY plasma spray coated Rene 41 rods were thermal cycled to 1040 C in a Mach 0.3-Jet A/air burner flame. The experimental results indicate the existance of a minimum or threshold power level which coating life expectancy is less than 500 cycles. Above the threshold power level, coating life expectancy more than doubles and increases with arc current.

Effects of arc current on the life in burner rig thermal cycling of plasma sprayed ZrOsub2-Ysub2Osub3

NASA Astrophysics Data System (ADS)

Hendricks, R. C.; McDonald, G.

1982-02-01

An analysis of thermal cycle life data for four sets of eight thermal barrier coated specimens representing arc currents (plasma gun power) of 525, 600, 800, or 950 amps is presented. The ZrO2-8Y2O3/NiCrAlY plasma spray coated Rene 41 rods were thermal cycled to 1040 C in a Mach 0.3-Jet A/air burner flame. The experimental results indicate the existance of a minimum or threshold power level which coating life expectancy is less than 500 cycles. Above the threshold power level, coating life expectancy more than doubles and increases with arc current.

Gene disruption reveals a dispensable role for plasmepsin VII in the Plasmodium berghei life cycle.

PubMed

Mastan, Babu S; Kumari, Anchala; Gupta, Dinesh; Mishra, Satish; Kumar, Kota Arun

2014-06-01

Plasmepsins (PM), aspartic proteases of Plasmodium, comprises a family of ten proteins that perform critical functions in Plasmodium life cycle. Except VII and VIII, functions of the remaining plasmepsin members have been well characterized. Here, we have generated a mutant parasite lacking PM VII in Plasmodium berghei using reverse genetics approach. Systematic comparison of growth kinetics and infection in both mosquito and vertebrate host revealed that PM VII depleted mutants exhibited no defects in development and progressed normally throughout the parasite life cycle. These studies suggest a dispensable role for PM VII in Plasmodium berghei life cycle. Copyright © 2014 Elsevier B.V. All rights reserved.

Security Risks: Management and Mitigation in the Software Life Cycle

NASA Technical Reports Server (NTRS)

Gilliam, David P.

2004-01-01

A formal approach to managing and mitigating security risks in the software life cycle is requisite to developing software that has a higher degree of assurance that it is free of security defects which pose risk to the computing environment and the organization. Due to its criticality, security should be integrated as a formal approach in the software life cycle. Both a software security checklist and assessment tools should be incorporated into this life cycle process and integrated with a security risk assessment and mitigation tool. The current research at JPL addresses these areas through the development of a Sotfware Security Assessment Instrument (SSAI) and integrating it with a Defect Detection and Prevention (DDP) risk management tool.

Nascent life cycles and the emergence of higher-level individuality.

PubMed

Ratcliff, William C; Herron, Matthew; Conlin, Peter L; Libby, Eric

2017-12-05

Evolutionary transitions in individuality (ETIs) occur when formerly autonomous organisms evolve to become parts of a new, 'higher-level' organism. One of the first major hurdles that must be overcome during an ETI is the emergence of Darwinian evolvability in the higher-level entity (e.g. a multicellular group), and the loss of Darwinian autonomy in the lower-level units (e.g. individual cells). Here, we examine how simple higher-level life cycles are a key innovation during an ETI, allowing this transfer of fitness to occur 'for free'. Specifically, we show how novel life cycles can arise and lead to the origin of higher-level individuals by (i) mitigating conflicts between levels of selection, (ii) engendering the expression of heritable higher-level traits and (iii) allowing selection to efficiently act on these emergent higher-level traits. Further, we compute how canonical early life cycles vary in their ability to fix beneficial mutations via mathematical modelling. Life cycles that lack a persistent lower-level stage and develop clonally are far more likely to fix 'ratcheting' mutations that limit evolutionary reversion to the pre-ETI state. By stabilizing the fragile first steps of an evolutionary transition in individuality, nascent higher-level life cycles may play a crucial role in the origin of complex life.This article is part of the themed issue 'Process and pattern in innovations from cells to societies'. © 2017 The Author(s).

Generation of Finite Life Distributional Goodman Diagrams for Reliability Prediction

NASA Technical Reports Server (NTRS)

Kececioglu, D.; Guerrieri, W. N.

1971-01-01

The methodology of developing finite life distributional Goodman diagrams and surfaces is described for presenting allowable combinations of alternating stress and mean stress to the design engineer. The combined stress condition is that of an alternating bending stress and a constant shear stress. The finite life Goodman diagrams and surfaces are created from strength distributions developed at various ratios of alternating to mean stress at particular cycle life values. The conclusions indicate that the Von Mises-Hencky ellipse, for cycle life values above 1000 cycles, is an adequate model of the finite life Goodman diagram. In addition, suggestions are made which reduce the number of experimental data points required in a fatigue data acquisition program.

Reduction of capacity decay in vanadium flow batteries by an electrolyte-reflow method

NASA Astrophysics Data System (ADS)

Wang, Ke; Liu, Le; Xi, Jingyu; Wu, Zenghua; Qiu, Xinping

2017-01-01

Electrolyte imbalance is a major issue with Vanadium flow batteries (VFBs) as it has a significant impact on electrolyte utilization and cycle life over extended charge-discharge cycling. This work seeks to reduce capacity decay and prolong cycle life of VFBs by adopting a novel electrolyte-reflow method. Different current density and various start-up time of the method are investigated in the charge-discharge tests. The results show that the capacity decay rate is reduced markedly and the cycle life is prolonged substantially by this method. In addition, the coulomb efficiency, voltage efficiency and energy efficiency remain stable during the whole cycle life test, which indicates this method has little impact on the long lifetime performance of the VFBs. The method is low-cost, simple, effective, and can be applied in industrial VFB productions.

A flexible metallic actuator using reduced graphene oxide as a multifunctional component.

PubMed

Meng, Junxing; Mu, Jiuke; Hou, Chengyi; Zhang, Qinghong; Li, Yaogang; Wang, Hongzhi

2017-09-14

Flexible actuators are widely in demand for many real-life applications. Considering that existing actuators based on polymers, low-dimensional materials and pore-rich materials are mostly limited by slow response rate, high driving voltage and poor stability, we report here a novel metal based flexible actuator which is fabricated simply through partial oxidation and nano-function of copper foil with the assistance of reduced graphene oxide. The obtained asymmetric metallic actuator is (electric-)thermally driven and exhibits fast response rate (∼2 s) and large curvature (2.4 cm -1 ) under a low voltage (∼1 V) with a sustainable operation of up to ∼50 000 cycles. The actuator can also be triggered by infrared irradiation and direct-heating under various conditions including air, water, and vacuum.

Experimental evolution of multicellularity using microbial pseudo-organisms.

PubMed

Queller, David C; Strassmann, Joan E

2013-02-23

In a major evolutionary transition to a new level of organization, internal conflicts must be controlled before the transition can truly be successful. One such transition is that from single cells to multicellularity. Conflicts among cells in multicellular organisms can be greatly reduced if they consist of genetically identical clones. However, mutations to cheaters that experience one round of within-individual selection could still be a problem, particularly for certain life cycles. We propose an experimental evolution method to investigate this issue, using micro-organisms to construct multicellular pseudo-organisms, which can be evolved under different artificial life cycles. These experiments can be used to test the importance of various life cycle features in maintaining cooperation. They include structured reproduction, in which small propagule size reduces within-individual genetic variation. They also include structured growth, which increases local relatedness within individual bodies. Our method provides a novel way to test how different life cycles favour cooperation, even for life cycles that do not exist.

Progress in Multi-Disciplinary Data Life Cycle Management

NASA Astrophysics Data System (ADS)

Jung, C.; Gasthuber, M.; Giesler, A.; Hardt, M.; Meyer, J.; Prabhune, A.; Rigoll, F.; Schwarz, K.; Streit, A.

2015-12-01

Modern science is most often driven by data. Improvements in state-of-the-art technologies and methods in many scientific disciplines lead not only to increasing data rates, but also to the need to improve or even completely overhaul their data life cycle management. Communities usually face two kinds of challenges: generic ones like federated authorization and authentication infrastructures and data preservation, and ones that are specific to their community and their respective data life cycle. In practice, the specific requirements often hinder the use of generic tools and methods. The German Helmholtz Association project ’’Large-Scale Data Management and Analysis” (LSDMA) addresses both challenges: its five Data Life Cycle Labs (DLCLs) closely collaborate with communities in joint research and development to optimize the communities data life cycle management, while its Data Services Integration Team (DSIT) provides generic data tools and services. We present most recent developments and results from the DLCLs covering communities ranging from heavy ion physics and photon science to high-throughput microscopy, and from DSIT.

Future of lignite resources: a life cycle analysis.

PubMed

Wang, Qingsong; Liu, Wei; Yuan, Xueliang; Zheng, Xiaoning; Zuo, Jian

2016-12-01

Lignite is a low-quality energy source which accounts for 13 % of China's coal reserves. It is imperative to improve the quality of lignite for large-scale utilization. To further explore and analyze the influence of various key processes on the environment and economic costs, a lignite drying and compression technology is evaluated using an integrated approach of life cycle assessment and life cycle costs. Results showed that lignite mining, direct air emissions, and electricity consumption have most significant impacts on the environment. An integrated evaluation of life cycle assessment and life cycle costs showed that the most significant contributor to the environmental impacts and economic costs was the lignite mining process. The impact of transportation and wastewater treatment process on the environment and economic costs was small enough to be ignored. Critical factors were identified for reducing the environmental and economic impacts of lignite drying and compression technology. These findings provide useful inputs for both industrial practice and policy making for exploitation, processing, and utilization of lignite resources.

OF TRYPANOSOMATIDS. ENDOTRANSFORMATIONS AND ABERRATIONS].

PubMed

Frolov, A O; Malysheva, M N; Kostygov, A Yu

2016-01-01

Endotransformations and aberrations of the life cycle in the evolutionary history of trypanosomatids (Kinetoplastea: Trypanosomatidae) are analyzed. We treat the term "endotransformations" as evolutionarily fixed changes of phases and/or developmental stages of parasites. By contrast, we treat aberrations as evolutionary unstable, periodically arising deformations of developmental phases of trypanosomatids, never leading to life cycle changes. Various examples of life cycle endotransformations and aberrations in representatives of the family Trypanosomatidae are discussed.

The effect of social interactions in the primary consumption life cycle of motion pictures

NASA Astrophysics Data System (ADS)

Hidalgo R, César A.; Castro, Alejandra; Rodriguez-Sickert, Carlos

2006-04-01

We develop a 'basic principles' model which accounts for the primary life cycle consumption of films as a social coordination problem in which information transmission is governed by word of mouth. We fit the analytical solution of such a model to aggregated consumption data from the film industry and derive a quantitative estimator of its quality based on the structure of the life cycle.

Ontology for Life-Cycle Modeling of Water Distribution Systems: Model View Definition

DTIC Science & Technology

2013-06-01

Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) to develop a life-cycle building model have resulted in the...Laboratory (ERDC-CERL) to develop a life-cycle building model have resulted in the definition of a “core” building information model that contains...developed experimental BIM models us- ing commercial off-the-shelf (COTS) software. Those models represent three types of typical low-rise Army

A Gap Analysis of Life Cycle Management Commands and Best Purchasing and Supply Management Organizations

DTIC Science & Technology

2013-01-01

of the Army’s Life Cycle Management Commands (LCMCs)—those for Aviation and Missiles (AMCOM), Communications - Electronics (CECOM), and Tank-automotive...took time from their busy schedules to participate in our interviews. We would like to thank Lieutenant Colonel John Coombs for helping us track down...Army Communications -Electronics Life Cycle Management Command CPFR collaborative planning, forecasting, and replenishment DCMA Defense Contract

Performance Based Logistics... What’s Stopping Us

DTIC Science & Technology

2016-03-01

performance-based life cycle product support, where outcomes are acquired through performance-based arrangements that deliver Warfighter requirements and...correlates to the acquisition life cycle framework: spend the time and effort to identify and lock in the PBL requirements; conduct an analysis to...PDASD[L&MR]) on PBL strategies. The study, Project Proof Point: A Study to Determine the Impact of Performance Based Logistics (PBL) on Life Cycle

Evolution of haploid-diploid life cycles when haploid and diploid fitnesses are not equal.

PubMed

Scott, Michael F; Rescan, Marie

2017-02-01

Many organisms spend a significant portion of their life cycle as haploids and as diploids (a haploid-diploid life cycle). However, the evolutionary processes that could maintain this sort of life cycle are unclear. Most previous models of ploidy evolution have assumed that the fitness effects of new mutations are equal in haploids and homozygous diploids, however, this equivalency is not supported by empirical data. With different mutational effects, the overall (intrinsic) fitness of a haploid would not be equal to that of a diploid after a series of substitution events. Intrinsic fitness differences between haploids and diploids can also arise directly, for example because diploids tend to have larger cell sizes than haploids. Here, we incorporate intrinsic fitness differences into genetic models for the evolution of time spent in the haploid versus diploid phases, in which ploidy affects whether new mutations are masked. Life-cycle evolution can be affected by intrinsic fitness differences between phases, the masking of mutations, or a combination of both. We find parameter ranges where these two selective forces act and show that the balance between them can favor convergence on a haploid-diploid life cycle, which is not observed in the absence of intrinsic fitness differences. © 2016 The Author(s). Evolution © 2016 The Society for the Study of Evolution.

Life cycle assessment of fuel ethanol produced from soluble sugar in sweet sorghum stalks in North China

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding, Ning; Yang, Yang; Cai, Hao

This paper describes the results of a life cycle assessment of sweet sorghum stalk (SSS)-based ethanol in North China. We determined the environmental performance of SSS-based ethanol and examined its advantages and disadvantages, as compared to gasoline, focusing on the life cycle of feedstock production, transportation, ethanol production and distribution, and use. The GREET transportation model and the method developed by the Centre of Environmental Sciences at Leiden University (CML method) were used to compile a life cycle inventory and to assess environmental impacts. Results indicate that SSS-based ethanol has advantages in terms of energy consumption, with a well tomore » wheel decrease of 85% fossil energy and 44% global warming potential, as compared with gasoline. Abiotic depletion potential, acidification potential, and photochemical ozone creation potential were also 50–90% lower than in the case of gasoline, while human health toxic potential was 36% lower. However, SSS-based sorghum did not have advantages over gasoline in terms of life cycle cost, land use, and water consumption. Results indicate that such an evaluation cannot just consider a few types of environmental impacts, researchers should promote systematic and comprehensive life cycle assessment of ethanol to guide the development of an energy strategy for China.« less

Policy implications of uncertainty in modeled life-cycle greenhouse gas emissions of biofuels.

PubMed

Mullins, Kimberley A; Griffin, W Michael; Matthews, H Scott

2011-01-01

Biofuels have received legislative support recently in California's Low-Carbon Fuel Standard and the Federal Energy Independence and Security Act. Both present new fuel types, but neither provides methodological guidelines for dealing with the inherent uncertainty in evaluating their potential life-cycle greenhouse gas emissions. Emissions reductions are based on point estimates only. This work demonstrates the use of Monte Carlo simulation to estimate life-cycle emissions distributions from ethanol and butanol from corn or switchgrass. Life-cycle emissions distributions for each feedstock and fuel pairing modeled span an order of magnitude or more. Using a streamlined life-cycle assessment, corn ethanol emissions range from 50 to 250 g CO(2)e/MJ, for example, and each feedstock-fuel pathway studied shows some probability of greater emissions than a distribution for gasoline. Potential GHG emissions reductions from displacing fossil fuels with biofuels are difficult to forecast given this high degree of uncertainty in life-cycle emissions. This uncertainty is driven by the importance and uncertainty of indirect land use change emissions. Incorporating uncertainty in the decision making process can illuminate the risks of policy failure (e.g., increased emissions), and a calculated risk of failure due to uncertainty can be used to inform more appropriate reduction targets in future biofuel policies.

Micro-hybrid electric vehicle application of valve-regulated lead-acid batteries in absorbent glass mat technology: Testing a partial-state-of-charge operation strategy

NASA Astrophysics Data System (ADS)

Schaeck, S.; Stoermer, A. O.; Hockgeiger, E.

The BMW Group has launched two micro-hybrid functions in high volume models in order to contribute to reduction of fuel consumption in modern passenger cars. Both the brake energy regeneration (BER) and the auto-start-stop function (ASSF) are based on the conventional 14 V vehicle electrical system and current series components with only little modifications. An intelligent control algorithm of the alternator enables recuperative charging in braking and coasting phases, known as BER. By switching off the internal combustion engine at a vehicle standstill the idling fuel consumption is effectively reduced by ASSF. By reason of economy and package a lead-acid battery is used as electrochemical energy storage device. The BMW Group assembles valve-regulated lead-acid (VRLA) batteries in absorbent glass mat (AGM) technology in the micro-hybrid electrical power system since special challenges arise for the batteries. By field data analysis a lower average state-of-charge (SOC) due to partial state-of-charge (PSOC) operation and a higher cycling rate due to BER and ASSF are confirmed in this article. Similar to a design of experiment (DOE) like method we present a long-term lab investigation. Two types of 90 Ah VRLA AGM batteries are operated with a test bench profile that simulates the micro-hybrid vehicle electrical system under varying conditions. The main attention of this lab testing is focused on capacity loss and charge acceptance over cycle life. These effects are put into context with periodically refresh charging the batteries in order to prevent accelerated battery aging due to hard sulfation. We demonstrate the positive effect of refresh chargings concerning preservation of battery charge acceptance. Furthermore, we observe moderate capacity loss over 90 full cycles both at 25 °C and at 3 °C battery temperature.

Computer Software for Life Cycle Cost.

DTIC Science & Technology

1987-04-01

34 111. 1111I .25 IL4 jj 16 MICROCOPY RESOLUTION TEST CHART hut FILE C AIR CoMMNAMN STFF COLLG STUJDET PORTO i COMpUTER SOFTWARE FOR LIFE CYCLE CO879...obsolete), physical life (utility before physically wearing out), or application life (utility in a given function)." (7:5) The costs are usually

Improving cycle life of layered lithium transition metal oxide (LiMO2) based positive electrodes for Li ion batteries by smart selection of the electrochemical charge conditions

NASA Astrophysics Data System (ADS)

Kasnatscheew, Johannes; Evertz, Marco; Streipert, Benjamin; Wagner, Ralf; Nowak, Sascha; Cekic Laskovic, Isidora; Winter, Martin

2017-08-01

Increasing the specific energy of a lithium ion battery and maintaining its cycle life is a predominant goal and major challenge for electrochemical energy storage applications. Focusing on the positive electrode as the specific energy bottleneck, cycle life characteristics of promising layered oxide type active materials (LiMO2) has been thoroughly investigated. Comparing the variety of LiMO2 compositions, it could be shown that the "Ni-rich" (Ni ≥ 60% for M in LiMO2) electrodes expectably revealed best performance compromises between specific energy and cycle life at 20 °C, but only LiNi0.6Mn0.2Co0.2O2 (NMC622) could also maintain sufficient cycle performance at elevated temperatures. Focusing on NMC622, it could be demonstrated that the applied electrochemical conditions (charge capacity, delithiation amount) in the formation cycles significantly influence the subsequent cycling performance. Moreover, the insignificant transition metal dissolution, demonstrated by means of total X-ray fluorescence (TXRF) technique, and unchanged lithiation degree in the discharged state, determined by the measurement of the Li+ content by means of the inductively coupled plasma optical emission spectroscopy (ICP-OES) technique, pointed to a delithiation (charge) hindrance capacity fade mechanism. Considering these insights, thoughtful modifications of the electrochemical charge conditions could significantly prolong the cycle life.

14 CFR 170.13 - Airport Traffic Control Tower (ATCT) establishment criteria.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the present value of the ATCT life cycle benefits (BPV) to the present value of ATCT life cycle costs... traffic during the expected life of the tower facility. (An FAA annual count is a fiscal year or a...

14 CFR 170.13 - Airport Traffic Control Tower (ATCT) establishment criteria.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the present value of the ATCT life cycle benefits (BPV) to the present value of ATCT life cycle costs... traffic during the expected life of the tower facility. (An FAA annual count is a fiscal year or a...

14 CFR 170.13 - Airport Traffic Control Tower (ATCT) establishment criteria.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the present value of the ATCT life cycle benefits (BPV) to the present value of ATCT life cycle costs... traffic during the expected life of the tower facility. (An FAA annual count is a fiscal year or a...

14 CFR 170.13 - Airport Traffic Control Tower (ATCT) establishment criteria.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the present value of the ATCT life cycle benefits (BPV) to the present value of ATCT life cycle costs... traffic during the expected life of the tower facility. (An FAA annual count is a fiscal year or a...

Margaret Mann | NREL

Science.gov Websites

feasibility analysis Environmental analysis Strategic planning for market development Research Interests Life -1991) Other Affiliations Executive Board, American Center for Life Cycle Assessment, 2004-present Advisory member of the North American Life Cycle Inventory Database Project Member, Society of

High temperature, low cycle fatigue of copper-base alloys in argon. Part 3: Zirconium-copper; thermal-mechanical strain cycling, hold-time and notch fatigue results

NASA Technical Reports Server (NTRS)

Conway, J. B.; Stentz, R. H.; Berling, J. T.

1973-01-01

The low-cycle fatigue characteristics of smooth bar and notched bar specimens (hourglass shape) of zirconium-copper, 1/2 Hard, material (R-2 Series) were evaluated at room temperature in axial strain control. Over the fatigue life range from about 300 to 3000 cycles the ratio of fatigue life for smooth bar to fatigue life for notched bar remained constant at a value of about 6.0. Some additional hold-time data for the R-2 alloy tested in argon at 538 C are reported. An analysis of the relaxation data obtained in these hold-time tests is also reported and it is shown that these data yield a fairly consistent correlation in terms of instantaneous stress rate divided by instantaneous stress. Two thermal-mechanical strain cycling tests were also performed using a cyclic frequency of 4.5 cycles per hour and a temperature cycling interval from 260 to 538 C. The fatigue life values in these tests were noticeably lower than that observed in isothermal tests at 538 C.

Out with the old, in with the new: Assessing change in screen time when measurement changes over time.

PubMed

Gunnell, Katie E; Brunet, Jennifer; Bélanger, Mathieu

2018-03-01

We examined if screen time can be assessed over time when the measurement protocol has changed to reflect advances in technology. Beginning in 2011, 929 youth (9-12 years at time one) living in in New Brunswick (Canada) self-reported the amount of time spent watching television (cycles 1-13), using computers (cycles 1-13), and playing video games (cycles 3-13). Using longitudinal invariance to test a shifting indicators model of screen time, we found that the relationships between the latent variable reflecting overall screen time and the indicators used to assess screen time were invariant across cycles (weak invariance). We also found that 31 out of 37 indicator intercepts were invariant, meaning that most indicators were answered similarly (i.e., on the same metric) across cycles (partial strong invariance), and that 28 out of 37 indicator residuals were invariant indicating that similar sources of error were present over time (partial strict invariance). Overall, across all survey cycles, 76% of indicators were fully invariant. Whereas issues were noted when new examples of screen-based technology (e.g., iPads) were added, having established partial invariance, we suggest it is still possible to assess change in screen time despite having changing indicators over time. Although it is not possible to draw definitive conclusions concerning other self-report measures of screen time, our findings may assist other researchers considering modifying self-report measures in longitudinal studies to reflect technological advancements and increase the precision of their results.

Life Cycle Reversal in Aurelia sp.1 (Cnidaria, Scyphozoa)

PubMed Central

He, Jinru; Zheng, Lianming; Zhang, Wenjing; Lin, Yuanshao

2015-01-01

The genus Aurelia is one of the major contributors to jellyfish blooms in coastal waters, possibly due in part to hydroclimatic and anthropogenic causes, as well as their highly adaptive reproductive traits. Despite the wide plasticity of cnidarian life cycles, especially those recognized in certain Hydroza species, the known modifications of Aurelia life history were mostly restricted to its polyp stage. In this study, we document the formation of polyps directly from the ectoderm of degenerating juvenile medusae, cell masses from medusa tissue fragments, and subumbrella of living medusae. This is the first evidence for back-transformation of sexually mature medusae into polyps in Aurelia sp.1. The resulting reconstruction of the schematic life cycle of Aurelia reveals the underestimated potential of life cycle reversal in scyphozoan medusae, with possible implications for biological and ecological studies. PMID:26690755

Exploring the life cycles of three South American rusts that have potential as biocontrol agents of the stipoid grass Nassella neesiana in Australasia.

PubMed

Anderson, Freda E; Díaz, Marina L; Barton, Jane; Flemmer, Andrea C; Hansen, Paula V; McLaren, David A

2011-01-01

Three rusts, Puccinia nassellae, Uromyces pencanus, and Puccinia graminella, are being studied as potential biological control agents for Nassella neesiana (Chilean needle grass) in Australia and New Zealand. An understanding of the life cycle of a pathogen is desirable before its release as a biocontrol agent is considered, to enable the assessment of the risks involved in such a release. Field observations and experiments have been carried out to elucidate the life cycles of these three pathogens. Puccinia nassellae cycles as urediniospores and produces dormant teliospores. Dormancy of teliospores has been broken through manipulation in the laboratory, but resulting basidiospores have failed to infect N. neesiana plants under the conditions tested. Uromyces pencanus cycles as urediniospores and its telia appear to have lost the capacity to produce basidiospores. Aecia have been reported for this rust in the literature. However, evidence is provided that these aecia in fact belong to the life cycle of P. graminella. Puccinia graminella produces only aecia and telia. The aeciospores have been shown to be repetitive (aecidioid urediniospores). Teliospores germinate directly without a dormant phase, but resulting basidiospores failed to infect N. neesiana plants under the conditions tested. The role of teliospores in the life cycle of all three rusts remains unknown. Although the autoecious nature of their life cycles has not been proven experimentally, neither is there any evidence that they are heteroecious. Practical and theoretical implications of these findings are discussed. Copyright © 2011 The British Mycological Society. All rights reserved.

A putative APSES transcription factor is necessary for normal growth and development of Aspergillus nidulans.

PubMed

Lee, Ji-Yeon; Kim, Lee-Han; Kim, Ha-Eun; Park, Jae-Sin; Han, Kap-Hoon; Han, Dong-Min

2013-12-01

The nsdD gene encoding a GATA type transcription factor positively controls sexual development in Aspergillus nidulans. According to microarray data, 20 genes that were upregulated by deleting nsdD during various life cycle stages were randomly selected and deleted for functional analysis. None of the mutants showed apparent changes in growth or development compared with those of the wild-type except the AN3154 gene that encodes a putative APSES transcription factor and is an ortholog of Saccharomyces cerevisiae swi4. Deleting AN3154 resulted in retarded growth and development, and the gene was named rgdA (retared growth and development). The rgdA deletion mutant developed a reduced number of conidia even under favorable conditions for asexual development. The retarded growth and development was partially suppressed by the veA1 mutation. The conidial heads of the mutant aborted, showing reduced and irregular shaped phialides. Fruiting body development was delayed compared with that in the wild-type. The mutant did not respond to various nutritional or environmental factors that affected the development patterns. The rgdA gene was expressed at low levels throughout the life cycle and was not significantly affected by several regulators of sexual and asexual development such as nsdD, veA, stuA, or brlA. However, the rgdA gene affected brlA and abaA expression, which function as key regulators of asexual sporulation, suggesting that rgdA functions upstream of those genes.

LIFE CYCLE DESIGN OF A FUEL TANK SYSTEM

EPA Science Inventory

This life cycle design (LCD) project was a collaborative effort between the National Pollution Prevention Center at the University of Michigan, General Motors (GM), and the U.S. Environmental Protection Agency (EPA). The primary objective of this project was to apply life cyc...

Simple graph models of information spread in finite populations

PubMed Central

Voorhees, Burton; Ryder, Bergerud

2015-01-01

We consider several classes of simple graphs as potential models for information diffusion in a structured population. These include biases cycles, dual circular flows, partial bipartite graphs and what we call ‘single-link’ graphs. In addition to fixation probabilities, we study structure parameters for these graphs, including eigenvalues of the Laplacian, conductances, communicability and expected hitting times. In several cases, values of these parameters are related, most strongly so for partial bipartite graphs. A measure of directional bias in cycles and circular flows arises from the non-zero eigenvalues of the antisymmetric part of the Laplacian and another measure is found for cycles as the value of the transition probability for which hitting times going in either direction of the cycle are equal. A generalization of circular flow graphs is used to illustrate the possibility of tuning edge weights to match pre-specified values for graph parameters; in particular, we show that generalizations of circular flows can be tuned to have fixation probabilities equal to the Moran probability for a complete graph by tuning vertex temperature profiles. Finally, single-link graphs are introduced as an example of a graph involving a bottleneck in the connection between two components and these are compared to the partial bipartite graphs. PMID:26064661

Cradle-to-gate life-cycle assessment of laminated veneer lumber produced in the southeast region of the United States

Treesearch

Richard D. Bergman; Sevda Alanya-Rosenbaum

2017-01-01

The goal of the present study was to develop life-cycle impact assessment (LCIA) data associated with gate-to-gate laminated veneer lumber (LVL) production in the southeast (SE) region of the U.S. with the ultimate aim of constructing an updated cradle-to-gate mill output life-cycle assessment (LCA). The authors collected primary (survey) mill data from LVL production...

Life Cycle Costing in Government Procurement.

DTIC Science & Technology

1985-05-01

in many areas continue to do so today. However, as business decisions grow in complexity the "gut" reaction approach to minimizing the total costs of...predictors of future events) in 0 determining the most cost effectiv- approach to future - operations. Under "classic" life cycle costing the concepts of... in the FAR and occasional references appear to include life cycle costs within price.8 However in practice , use of the word

Life Cycle Assessment of III-V Precursors for Photovoltaic and Semiconductor Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Horowitz, Kelsey A; Smith, Brittany L.; Babbitt, Callie W.

This study provides detailed information on the manufacture of III-V metal organic vapor phase epitaxy precursors through extensive literature and patent research. This data informed a cradle-to-gate life cycle assessment of these chemicals. Reported impacts include cumulative energy demand and greenhouse gas emissions. The results were interpreted to identify sources of environmental burden within the life cycle and were compared to energy demand reported in previous studies.

Ontology for Life-Cycle Modeling of Water Distribution Systems: Application of Model View Definition Attributes

DTIC Science & Technology

2013-06-01

ER D C/ CE RL C R- 13 -5 Ontology for Life-Cycle Modeling of Water Distribution Systems : Application of Model View Definition...2013 Ontology for Life-Cycle Modeling of Water Distribution Systems : Application of Model View Definition Attributes Kristine K. Fallon, Robert A...interior plumbing systems and the information exchange requirements for every participant in the design. The findings were used to develop an

Teamed for Success: The Imperative for Aligning Systems Engineering and Life Cycle Logistics

DTIC Science & Technology

2013-02-01

January-February 2013 Kobren is director of the DAU Logistics & Sustainment Center, and the DoD Product Support Assessment Human Capital IPT lead...engineering colleagues, here are 10 key life-cycle logistics, product support, and system sustainment tenets to be cognizant of: Decisions You Make Will...and updates to the Life Cycle Sustainment Plan (LCSP). A vast majority of a weapon systems’ total ownership costs are determined by decisions made

Survey of Methods to Assess the Toxicological Impact of Hazardous Waste Disposal Sites on Aquatic Ecosystems

DTIC Science & Technology

1989-07-01

generalized life cycles of marine invertebrates .................... 6 2. Effect of potassium dichromate (K2CrO,) on the growth of Scenedesmus suhspicatus. 0...agencies, the more commonly used tools will be discussed. TOXICOLOGICAL IMPACTS TO AQUATIC ORGANISMS In the typical life cycle of marine invertebrates ...generalized life cycles of marine invertebrates . 1984). Direct comparisons of bioassay results are limited to examining effects of varying concentrations of

The Impact of Technological Change in Electronic Repairables on the Acquisition Process at Navy Ships Parts Control Center Mechanicsburg.

DTIC Science & Technology

1981-03-01

58 H. CONTRACTING REQUIREM4ENTS----------------------- 5 I. 4G LIFE CYCLE USAGE---------------------------- 61 J. SUMMARY...procurement data is transferred during the life cycle of an item. The virtual revolution in electronics technology every five years is straining the abilities...naval operations throughout the systems/equipment life cycle [151. NAVELEX manages temporary parts inventories during the design and development of new

An Analysis of the President’s Budgetary Proposals for Fiscal Year 2006

DTIC Science & Technology

2005-03-01

Domestic Product (Average percentage change from CBO’s baseline) Source: Congressional Budget Office. Notes: The “textbook” growth model is an...Global Insight Closed-Economy Life-Cycle Model Open-Economy Life-Cycle Model Textbook Model Memorandum: Gross National Product Open-Economy Life-Cycle...domestic product in the models . 2. Over time, however, increased investment will enlarge the capital stock, in turn reducing the pretax rate of return and

Life Cycle Assessment Perspectives on Delivering an Infant in the US

PubMed Central

Campion, Nicole; Thiel, Cassandra L.; DeBlois, Justin; Woods, Noe C.; Landis, Amy E.; Bilec, Melissa M.

2012-01-01

This study introduces life cycle assessment as a tool to analyze one aspect of sustainability in healthcare: the birth of a baby. The process life cycle assessment case study presented evaluates two common procedures in a hospital, a cesarean section and a vaginal birth. This case study was conducted at Magee-Womens Hospital of the University of Pittsburgh Medical Center, which delivers over 10,000 infants per year. The results show that heating, ventilation, and air conditioning (HVAC), waste disposal, and the production of the disposable custom packs comprise a large percentage of the environmental impacts. Applying the life cycle assessment tool to medical procedures allows hospital decision makers to target and guide efforts to reduce the environmental impacts of healthcare procedures. PMID:22482785

Gallium arsenide solar array subsystem study

NASA Technical Reports Server (NTRS)

Miller, F. Q.

1982-01-01

The effects on life cycle costs of a number of technology areas are examined for a gallium arsenide space solar array. Four specific configurations were addressed: (1) a 250 KWe LEO mission - planer array; (2) a 250 KWe LEO mission - with concentration; (3) a 50 KWe GEO mission planer array; (4) a 50 KWe GEO mission - with concentration. For each configuration, a baseline system conceptual design was developed and the life cycle costs estimated in detail. The baseline system requirements and design technologies were then varied and their relationships to life cycle costs quantified. For example, the thermal characteristics of the baseline design are determined by the array materials and masses. The thermal characteristics in turn determine configuration, performance, and hence life cycle costs.

Modeling the Ebolavirus Life Cycle with Transcription and Replication-Competent Viruslike Particle Assays.

PubMed

Biedenkopf, Nadine; Hoenen, Thomas

2017-01-01

Ebolaviruses are the causative agent of a severe hemorrhagic fever with high case fatality rates, for which no approved specific therapy is available. As biosafety level 4 (BSL4) agents, work with live ebolaviruses is restricted to maximum containment laboratories. Transcription and replication-competent viruslike particle (trVLP) systems are reverse genetics-based life cycle modeling systems that allow researchers to model virtually the entire ebolavirus life cycle outside of a maximum containment laboratory. These systems can be used to dissect the virus life cycle, and thus increase our understanding of virus biology, as well as for more applied uses such as the screening and development of novel antivirals, and thus represent powerful tools for work on ebolaviruses.

Advanced Launch Technology Life Cycle Analysis Using the Architectural Comparison Tool (ACT)

NASA Technical Reports Server (NTRS)

McCleskey, Carey M.

2015-01-01

Life cycle technology impact comparisons for nanolauncher technology concepts were performed using an Affordability Comparison Tool (ACT) prototype. Examined are cost drivers and whether technology investments can dramatically affect the life cycle characteristics. Primary among the selected applications was the prospect of improving nanolauncher systems. As a result, findings and conclusions are documented for ways of creating more productive and affordable nanolauncher systems; e.g., an Express Lane-Flex Lane concept is forwarded, and the beneficial effect of incorporating advanced integrated avionics is explored. Also, a Functional Systems Breakdown Structure (F-SBS) was developed to derive consistent definitions of the flight and ground systems for both system performance and life cycle analysis. Further, a comprehensive catalog of ground segment functions was created.

Development and application of basis database for materials life cycle assessment in china

NASA Astrophysics Data System (ADS)

Li, Xiaoqing; Gong, Xianzheng; Liu, Yu

2017-03-01

As the data intensive method, high quality environmental burden data is an important premise of carrying out materials life cycle assessment (MLCA), and the reliability of data directly influences the reliability of the assessment results and its application performance. Therefore, building Chinese MLCA database is the basic data needs and technical supports for carrying out and improving LCA practice. Firstly, some new progress on database which related to materials life cycle assessment research and development are introduced. Secondly, according to requirement of ISO 14040 series standards, the database framework and main datasets of the materials life cycle assessment are studied. Thirdly, MLCA data platform based on big data is developed. Finally, the future research works were proposed and discussed.

Comparing the Life Cycle Energy Consumption, Global ...

EPA Pesticide Factsheets

Managing the water-energy-nutrient nexus for the built environment requires, in part, a full system analysis of energy consumption, global warming and eutrophication potentials of municipal water services. As an example, we evaluated the life cycle energy use, greenhouse gas (GHG) emissions and aqueous nutrient releases of the whole anthropogenic municipal water cycle starting from raw water extraction to wastewater treatment and reuse/discharge for five municipal water and wastewater systems. The assessed options included conventional centralized services and four alternative options following the principles of source-separation and water fit-for-purpose. The comparative life cycle assessment identified that centralized drinking water supply coupled with blackwater energy recovery and on-site greywater treatment and reuse was the most energyand carbon-efficient water service system evaluated, while the conventional (drinking water and sewerage) centralized system ranked as the most energy- and carbon-intensive system. The electricity generated from blackwater and food residuals co-digestion was estimated to offset at least 40% of life cycle energy consumption for water/waste services. The dry composting toilet option demonstrated the lowest life cycle eutrophication potential. The nutrients in wastewater effluent are the dominating contributors for the eutrophication potential for the assessed system configurations. Among the parameters for which variability

Ecology and Life Cycle Patterns of Echinococcus Species.

PubMed

Romig, T; Deplazes, P; Jenkins, D; Giraudoux, P; Massolo, A; Craig, P S; Wassermann, M; Takahashi, K; de la Rue, M

2017-01-01

The genus Echinococcus is composed of eight generally recognized species and one genotypic cluster (Echinococcus canadensis cluster) that may in future be resolved into one to three species. For each species, we review existing information on transmission routes and life cycles in different geographical contexts and - where available - include basic biological information of parasites and hosts (e.g., susceptibility of host species). While some Echinococcus spp. are transmitted in life cycles that involve predominantly domestic animals (e.g., dog - livestock cycles), others are wildlife parasites that do or do not interact with domestic transmission. In many cases, life cycle patterns of the same parasite species differ according to geography. Simple life cycles contrast with transmission patterns that are highly complex, involving multihost systems that may include both domestic and wild mammals. Wildlife transmission may be primary or secondary, i.e., resulting from spillovers from domestic animals. For most of the species and regions, existing information does not yet permit a conclusive description of transmission systems. Such data, however, would be highly relevant, e.g., for anticipation of geographical changes of the presence and frequency of these parasites in a warming world, or for initiating evidence-based control strategies. Copyright © 2017 Elsevier Ltd. All rights reserved.