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Sample records for partial thromboplastin time

  1. Activated partial thromboplastin time: new tricks for an old dogma.

    PubMed

    Lippi, Giuseppe; Favaloro, Emmanuel J

    2008-10-01

    The activated partial thromboplastin time (APTT) is the most common coagulation test procedure performed in routine laboratories, apart from the prothrombin time. The test is traditionally used for identifying quantitative and qualitative abnormalities in the intrinsic and common pathways of coagulation, monitoring anticoagulant therapy with unfractionated heparin, and detecting inhibitors of blood coagulation, the most common of which is the lupus anticoagulant. Whereas short APTT values have been mostly overlooked in the past, recent evidence suggests that these might be associated with hypercoagulability. Although clinical relevance is yet to be clearly defined, hypercoagulability detected by a shortened APTT appears to be significantly associated with a major risk of venous thromboembolism independently from other variables such as blood group, the presence of inherited thrombophilia, and factor VIII levels. This novel finding suggests that this traditional, simple, and inexpensive test might have renewed utility along with traditional thrombophilic tests in the evaluation of venous thromboembolic risk. In addition, APTT waveform analysis is also providing mounting evidence of added utility, in particular for identifying sepsis and disseminated intravascular coagulation in critically ill patients (particularly where this might worsen the prognosis), for monitoring therapy in patients with inhibitors, and as a diagnostic aid to identify patients with antiphospholipid antibodies. In total, such emerging evidence suggests that the APTT is either an old dogma displaying new tricks or else might describe a new dogma for an old laboratory trick. PMID:19085761

  2. [Importance of Quick, partial thromboplastin time, and Co].

    PubMed

    Siegert, G

    2014-05-01

    The Quick test and activated partial thromboplastin time (aPTT) are so-called global assays used to characterize different steps in plasmatic hemostasis. They reflect hemostasis in its classical differentiation into extrinsic and intrinsic pathways. However, they do not cover physiological aspects of cell-based hemostasis. Results are not necessarily congruent with a specific clinical situation and do not replace a complete medical history. Patients suffering from hemophilia A or B, for example, have normal Quick test results. Severe factor XII deficiency reveals an extreme aPTT prolongation without a significant bleeding tendency. In Lupus patients, aPTT is also prolonged with clinically a rather increased thrombotic risk. Fibrinogen as a substrate of coagulation discloses pathological results in both global tests in case of considerable reduction. In case of positive bleeding history and a normal global assay, disorders in platelets, von Willebrand factor and factor XIII must be considered. Reduced Quick test results may be expected in factor VII, II, V, or X deficiency. Disorders of liver synthesis of coagulation factors as well as vitamin K deficiency will be indicated by the Quick test rather than by aPTT. The most frequent hereditary reasons for a prolonged aPTT are hemophilia A and B as well as von Willebrand disease. In case of an acquired bleeding tendency, the diagnostic strategy must include autoantibodies. The sensitivity of the aPTT reagent varies widely. Low-molecular weight heparin and pentasaccharides do not influence the test. Oral direct inhibitors may reveal pathological results in a reagent-dependent manner. PMID:24781934

  3. Partial thromboplastin time test with kaolin: diagnosis of haemophilia and Christmas disease without natural reference plasmas.

    PubMed

    Knights, S F; Ingram, G I

    1967-07-01

    Deficiencies of factor VIII (in haemophilia) and factor IX (in Christmas disease) prolong the partial thromboplastin time. If normal plasma is treated with alumina, the factor VIII remains but the factor IX is removed and can subsequently be recovered by elution of the alumina. If a long partial thromboplastin time is found on investigating a male patient whose history suggests a life-long bleeding disorder, the plasma may be retested after adding either alumina-adsorbed normal plasma or eluate. If the patient's partial thromboplastin time is shortened (relative to the control) by adding adsorbed normal plasma the patient is likely to be a haemophiliac; but if it is shortened by adding eluate then he is likely to have Christmas disease. Practical details for carrying out these manoeuvres are given and experiments on the validity of the test described.

  4. Decentralized testing for prothrombin time and activated partial thromboplastin time using a dry chemistry portable analyzer.

    PubMed

    Rose, V L; Dermott, S C; Murray, B F; McIver, M M; High, K A; Oberhardt, B J

    1993-06-01

    Previous work has established the precision and accuracy of a portable blood coagulation analysis system using paramagnetic particles contained in a dry reagent on a disposable test card. We examined the deployment of this technology in decentralized hospital settings and compared test results obtained in the surgical intensive care unit, coronary care unit, and outpatient cardiology clinic with those obtained in the central laboratory. Nursing personnel were instructed in the use of the system, and quality control testing was performed daily by the laboratory staff. In the intensive care units, patient subjects included those on whom tests of prothrombin time and activated partial thromboplastin time had been ordered. Immediate determinations were performed by the intensive care unit nursing staff on the same citrated, whole-blood samples that were subsequently sent to the central laboratory. In the outpatient cardiology clinic, fingerstick blood samples were obtained for prothrombin time determinations with the dry chemistry system. Paired prothrombin time samples obtained by venipuncture were run in the hospital laboratory. The study involved multiple users, multiple locations, two lots of activated partial thromboplastin time cards, and several different instruments, over an extended period. Correlation coefficients between the dry chemistry system and the hospital laboratory under these conditions were in an acceptable range in all sites studied. We concluded that, with appropriate training and quality assurance, the dry chemistry system provides an acceptable alternative to the hospital laboratory for prothrombin time and activated partial thromboplastin time determinations. PMID:8503733

  5. Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients

    PubMed Central

    Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yuki; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hideyuki; Kobayashi, Hikaru; Ishida, Fumihiro

    2016-01-01

    The activated partial thromboplastin time (APTT) assay is a basic hemostatic assay based on the time it takes for clots to form in plasma samples after the addition of calcium chloride. It is used to screen for various coagulation disorders. Several previous reports have suggested that magnesium (Mg) might contribute to coagulation reactions by binding to specific coagulation proteins. We investigated the effects of Mg on the APTT. In healthy controls, the APTT was significantly prolonged in proportion to the increase in the concentration of magnesium chloride in the range from 2.1 to 16.7 mmol/L. Among eight samples from patients with various disorders that exhibited prolonged APTT, two samples demonstrated shorter APTT when Mg was added, both of which were from patients that were positive for lupus anticoagulant. When we examined 206 clinical APTT samples, we found that Mg shortened the APTT of two samples. These two samples were also from lupus anticoagulant-positive patients (p-value: <0.003). Our findings regarding the unique effects of exogenous Mg on the APTT of lupus anticoagulant-positive patients might shed light on the role of Mg in APTT assays and lead to the development of a novel screening method for lupus anticoagulant. PMID:27355205

  6. Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients.

    PubMed

    Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yuki; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hideyuki; Kobayashi, Hikaru; Ishida, Fumihiro

    2016-01-01

    The activated partial thromboplastin time (APTT) assay is a basic hemostatic assay based on the time it takes for clots to form in plasma samples after the addition of calcium chloride. It is used to screen for various coagulation disorders. Several previous reports have suggested that magnesium (Mg) might contribute to coagulation reactions by binding to specific coagulation proteins. We investigated the effects of Mg on the APTT. In healthy controls, the APTT was significantly prolonged in proportion to the increase in the concentration of magnesium chloride in the range from 2.1 to 16.7 mmol/L. Among eight samples from patients with various disorders that exhibited prolonged APTT, two samples demonstrated shorter APTT when Mg was added, both of which were from patients that were positive for lupus anticoagulant. When we examined 206 clinical APTT samples, we found that Mg shortened the APTT of two samples. These two samples were also from lupus anticoagulant-positive patients (p-value: <0.003). Our findings regarding the unique effects of exogenous Mg on the APTT of lupus anticoagulant-positive patients might shed light on the role of Mg in APTT assays and lead to the development of a novel screening method for lupus anticoagulant.

  7. [Presence of inhibitors of activated partial thromboplastin time (TTPA). Clinical repercussion in obstetric patients].

    PubMed

    Bustos, H H; Huber, R; Baptista, H; Izquierdo, H; Sánchez Contreras, J

    1992-01-01

    Partial thromboplastin time, activated with kaolin (TTPA) is a qualitative test used to find defects of some factor of intrinsic via of coagulation or to rule out the presence of some circulating inhibitor. The lupus anticoagulant (LA) is part of a group of several auto-antibody with pathogenic potential in several branches of medicine, mainly rheumatology, hematology and gyneco-obstetrics. In this last area the LA has been associated with different obstetrical repercussions. The purpose of this study was to determine the main obstetrical events associated with patients with circulating anticoagulants identified by TTPA with kaolin. Ninety six patients were included in cases-control study. Group I (n = 48) cases and Group II (n = 48) controls, were selected from the same population and information source. The cases were included when presenting prolongation of more than 4 seconds of TTPA activated with kaolin regarding a control with lack of correction with normal plasma. A registration sheet for data captation, was designed specially for this study. The comparability of both groups was established, as there were no differences (significant) among the variable considered as basal. The group of cases presented with a greater frequency of habitual abortion, neonatal death and thrombotic phenomena. This relationship of autoimmunological pictures with recurrent fetal loss and thromboembolic incidents has been consistently described in literature. To this respect, several immunological abnormalities. Including positive anticardiolipin antibodies and VDRL falsely positive. The incidence, in this country of these entities, is unknown. These observations show the need of a methodologic superation.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. PARTIAL THROMBOPLASTIN TIME TEST WITH KAOLIN. NORMAL RANGE AND MODIFICATIONS FOR THE DIAGNOSIS OF HAEMOPHILIA AND CHRISTMAS DISEASE.

    PubMed

    MATCHETT, M O; INGRAM, G I

    1965-07-01

    The partial thromboplastin time test provides a convenient and sensitive screening procedure for deficiencies of thromboplastic factors, especially factors VIII and IX. The test is carried out after preincubating the plasma for 10 minutes with kaolin, and Inosithin is used as a platelet substitute. The ;normal range' of the test has been estimated in terms of the differences encountered between random normal plasmas tested in pairs, because individual patients are usually tested against single control subjects. A patient's partial thromboplastin time should be regarded as abnormal if it is more than six seconds longer than the control time. In the diagnosis of haemophilia, patients' plasmas with concentrations of factor VIII as low as about 20% might be regarded as being within the range of normal, if the selected control subject's factor VIII happened to lie near the lower end of the normal range. When mild haemophilia is suspected, discrimination may be improved by diluting both the patient's and the control plasmas 1 in 20 in haemophilic plasma. With the test modified in this way the clotting time is prolonged, though the range of differences among normal subjects is unaltered, and plasmas with factor VIII concentrations below about 30%, i.e., in undiluted plasma, would be unlikely to be regarded as normal. The partial thromboplastin time may be similarly modified as a screening test for factor IX deficiency.Some clinical examples are reported.

  9. Prothrombin time and partial thromboplastin time as a predictor of bleeding in patients with dengue hemorrhagic fever.

    PubMed

    Chua, M N; Molanida, R; de Guzman, M; Laberiza, F

    1993-01-01

    Eighty-nine pediatric patients admitted at the University of Santo Tomas Hospital from June to December 1992, with the clinical diagnosis of dengue hemorrhagic fever (DHF) were studied with the following objectives: To determine the possible use of hematocrit, platelet count, prothrombin time (PT) and partial thromboplastin time (PTT) as predictors of bleeding and outcome in patient with DHF. The following were established: PTT can be an index in predicting bleeding in DHF. The tendency to bleed is greater with prolongation of > 30 seconds; platelet count can be a predictor of mortality, with death six times greater among those platelet count < 50,000/microliters than those whose platelet count was > 50,000/microliters. PT can also predict bleeding in patients with DHF.

  10. Effect of storage conditions on prothrombin time, activated partial thromboplastin time and fibrinogen concentration on canine plasma samples

    PubMed Central

    Casella, Stefania; Giannetto, Claudia; Giudice, Elisabetta

    2010-01-01

    The present study was to assess the effect of storage conditions on prothrombin time (PT), activated partial thromboplastin time (aPTT) and fibrinogen concentration in blood samples of healthy dogs. Thirty-five dogs of various breeds were included in the study. Citrated blood samples were obtained and plasma was divided into four aliquots to assess selected clotting parameters by means of a coagulometer. The first aliquot was analysed within 1 h after collection, while the remaining 3 were stored at 8℃ for 4, 8 and 24 h, respectively. One-way repeated measures analysis of variance documented a significant decreasing effect on PT at 24 h compared to 8 h and on fibrinogen concentration after 8 and 24 h compared to sampling time and at 4 and 24 h compared to 8 h post sampling. In conclusion, the results of this study indicate that only fibrinogen appears prone to significant decrease. In fact, aPTT is not substantially affected by refrigeration for at least 24 h post sampling and PT showed a statistical difference that does not necessary indicate biological significance as the results obtained were within reference intervals for the dog. PMID:20458152

  11. Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Hypertensive Patients Attending a Tertiary Hospital in Calabar, Nigeria

    PubMed Central

    Nnenna Adaeze, Nnamani; Uchenna Emeribe, Anthony; Abdullahi Nasiru, Idris; Babayo, Adamu; Uko, Emmanuel K.

    2014-01-01

    Introduction. Several biomedical findings have established the effects of hypertension on haemostasis and roles of blood coagulation products in the clinical course of hypertension. Methods. This cross-sectional study aimed at determining effects of hypertension on prothrombin time (PT) and activated partial thromboplastin time (APTT) in hypertensive patients in comparison with normotensive subjects attending a tertiary hospital in Calabar. Forty-two (42) hypertensive patients and thirty-nine (39) normotensive control subjects were investigated for PT and APTT using Quick one-stage methods. Results. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) correlated positively with APTT (r = 0.3072, r = 0.4988; P < 0.05) in hypertensive patients. DBP, SBP, PT, and APTT were significantly higher in hypertensive patients when compared to normotensive subjects (P < 0.05). DBP correlated negatively with duration of illness (r = −0.3097; P < 0.05) in hypertensive patients and positively with age of normotensive subjects (r = 0.3523; P < 0.05). Conclusion. The results obtained indicated that measurements of PT and APTT may serve as indices for evaluating hemostatic abnormalities in hypertensive patients and guide for antihypertensive therapy. However, to have better understanding of hemostatic activities in hypertension, it is recommended to conduct D-dimer, platelet factors, and protein assays. PMID:25477963

  12. Impact of telavancin on prothrombin time and activated partial thromboplastin time as determined using point-of-care coagulometers.

    PubMed

    Ero, Michael P; Harvey, Nathaniel R; Harbert, Jack L; Janc, James W; Chin, Kay H; Barriere, Steven L

    2014-01-01

    Telavancin is approved in the United States, Canada, and Europe (At the time of submission, the telavancin European marketing authorization for nosocomial pneumonia was suspended until Theravance provides evidence of a new European Medicines Agency approved supplier) as an antibiotic to treat certain Gram-positive bacterial skin infections. Telavancin has been shown to prolong plasmatic prothrombin (PT) and activated partial thromboplastin (aPTT) clotting times in clinical diagnostic lab-based assays. In this study, we evaluated the potential for telavancin to prolong whole blood PT/International Normalized Ratio (INR) and aPTT tests on point-of-care (POC) instruments. Whole blood collected from 8 healthy subjects was supplemented with telavancin to final concentrations of 0, 10, 20, and 100 μg/ml. Final concentrations were selected to match trough, twice trough, and peak plasma levels following the approved 10 mg/kg dose. Four widely employed POC coagulation instruments were chosen to be representative of the POC platforms currently in use.. These systems were the Roche Coaguchek XS, the Abbott iSTAT, the ITC Hemochron SIG+, and the Alere INRatio2 POC devices. The PT/INR measured by the Coaguchek XS showed the greatest sensitivity to the presence of telavancin. The PT/INR measured by the Hemochron SIG+ and iSTAT were sensitive to telavancin but to a lesser extent. The INRatio2 was the least sensitive to the presence of telavancin when testing the whole blood PT/INR. Only the Hemochron SIG+ device was capable of measuring aPTT and showed a concentration-dependent increase in aPTT. This study supports the current recommendation that PT and aPTT monitoring be conducted immediately to the next dose of telavancin when coagulation parameters are tested using POC instrumentation. PMID:24132401

  13. Partial thromboplastin time (PTT)

    MedlinePlus

    ... help the blood clot. This is called the coagulation cascade. The PTT test looks at some of ... control blood clotting become over active ( disseminated intravascular coagulation ) Liver disease Difficulty absorbing nutrients from food ( malabsorption ) ...

  14. Indium-111-labeled platelets: effect of heparin on uptake by venous thrombi and relationship to the activated partial thromboplastin time

    SciTech Connect

    Fedullo, P.F.; Moser, K.M.; Moser, K.S.; Konopka, R.; Hartman, M.T.

    1982-09-01

    The goal of heparin thepapy in deep vein thrombosis is to prevent thrombus extension. The relationship between thrombus extension and the results of coagulation tests used to monitor heparin thepapy is unclear. To expose this relationship, we studied the effect of several heparin regimens on the accretion of indium-111-labeled platelets on fresh venous thrombi, as detected by gamma imaging, and monitored the activated partial thromboplastin time (APTT). Six dogs were treated with a 300-U/kg bolus of heparin followed by a 90-U/kg/hour heparin infusion, a dose of heparin sufficient to increase the APTT to levels greater than eight times baseline (APTT ratio); platelet accretion (thrombus imaging) occurred only after the heparin effect was reversed with protamine sulfate. Nineteen dogs were treated with a 150-U/kg bolus of heparin followed by a 4-hour, 45-U/kg/hour heparin infusion; a thrombus was demonstrated only after protamine injection in 12 (mean APTT ratio 1.3 +/- 0.19) and before protamine injection in seven. In thirteen of these 19 dogs, 30 minutes separated the platelet injection from heparin therapy, while in six this duration was less than 30 minutes. In four of these six dogs, thrombi were demonstrated before protamine therapy and at APTT ratios greater than 3.0. Finally, 10 dogs were treated with a 100-U/kg bolus followed by a 3-hour, 50-U/kg/hour heparin infusion, after which the APTT was allowed to return to baseline values spontaneously. In all 10 dogs, a thrombus was demonstrated only after cessation of the heparin infusion, and at a mean APTT ratio of 1.4 +/- 0.15 times baseline. These results suggest that, except with very early platelet injection, platelet accretion by thrombi is consistently inhibited by heparin at APTT ratios greater than 2.5.

  15. Circuit life versus bleeding risk: the impact of achieved activated partial thromboplastin time versus achieved filtration fraction.

    PubMed

    MacEwen, Clare; Watkinson, Peter; Winearls, Christopher

    2015-06-01

    Whilst prolonging hemofilter (circuit) life, heparin increases bleeding risk. The impact of achieved activated partial thromboplastin time (APTT) on circuit life and bleeding risk has not been assessed in a modern critically ill cohort. Lowering filtration fraction may be an alternative means of prolonging circuit life, but is often overlooked in critical care. An observational study of 309 consecutive circuits in a general intensive care unit was conducted using a wide target APTT range. Multilevel modeling was used to predict circuit life and bleeding according to achieved APTT and filtration fraction. Independent predictors of circuit failure (i.e. unplanned ending of treatment) included filtration fraction (P<0.001, HR 1.07 per 1% increase), peak APTT (P<0.001, HR 0.8 per 10 s increase or 0.3 APTR increase) and baseline PT (P=0.014, HR 0.91 for every 50% increase). The only significant predictor of bleeding was peak APTT (P=0.017, OR 1.05 per 10 s increase). Every 10 s APTT increase was associated with a 20% reduction in circuit failure, but a 5% increase in hemorrhage. A 3% reduction in filtration fraction was associated with the same improvement in circuit life as a 10 s increase in APTT. Increasing APTT prolongs circuit life but carries a substantial risk of bleeding even in modern practice. Filtration fraction has a large impact on circuit life in the critically ill: a 3% reduction in filtration fraction, e.g. by increasing blood flow or delivering some of the clearance via dialysis, would be expected to reduce circuit failure as much as a 10 s increase in APTT.

  16. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study.

    PubMed

    Weng, Lu-Chen; Cushman, Mary; Pankow, James S; Basu, Saonli; Boerwinkle, Eric; Folsom, Aaron R; Tang, Weihong

    2015-04-15

    Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ∼50 000 SNPs in ∼2000 candidate genes. In EAs, the analyses identified a new independent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10(-8)), which clusters with a coding variant rs6030 (P-value = 7.8 × 10(-7)). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signals were identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10(-6)) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT. PMID:25552651

  17. A genetic association study of activated partial thromboplastin time in European Americans and African Americans: the ARIC Study

    PubMed Central

    Weng, Lu-Chen; Cushman, Mary; Pankow, James S.; Basu, Saonli; Boerwinkle, Eric; Folsom, Aaron R.; Tang, Weihong

    2015-01-01

    Reduced activated partial thromboplastin time (aPTT) is a risk marker for incident and recurrent venous thromboembolism (VTE). Genetic factors influencing aPTT are not well understood, especially in populations of non-European ancestry. The present study aimed to identify aPTT-related gene variants in both European Americans (EAs) and African Americans (AAs). We conducted a genetic association study for aPTT in 9719 EAs and 2799 AAs from the Atherosclerosis Risk in Communities (ARIC) study. Using the Candidate Gene Association Resource (CARe) consortium candidate gene array, the analyses were based on ∼50 000 SNPs in ∼2000 candidate genes. In EAs, the analyses identified a new independent association for aPTT in F5 (rs2239852, P-value = 1.9 × 10−8), which clusters with a coding variant rs6030 (P-value = 7.8 × 10−7). The remaining significant signals were located on F5, HRG, KNG1, F11, F12 and ABO and have been previously reported in EA populations. In AAs, significant signals were identified in KNG1, HRG, F12, ABO and VWF, with the leading variants in KNG1, HRG and F12 being the same as in the EAs; the significant variant in VWF (rs2229446, P-value = 1.2 × 10−6) was specific to the AA sample (minor allele frequency = 19% in AAs and 0.2% in EAs) and has not been previously reported. This is the first study to report aPTT-related genetic variants in AAs. Our findings in AAs demonstrate transferability of previously reported associations with KNG1, HRG and F12 in EAs. We also identified new associations at F5 in EAs and VWF in AAs that have not been previously reported for aPTT. PMID:25552651

  18. Prothrombin time and activated partial thromboplastin time using a point-of-care analyser (Abaxis VSpro®) in Bennett's wallabies (Macropus rufogriseus).

    PubMed

    Nevitt, B N; Chinnadurai, S K; Watson, M K; Langan, J N; Adkesson, M J

    2016-10-01

    There are few reports of coagulation times in marsupial species. Blood samples collected from 14 Bennett's wallabies (Macropus rufogriseus) under anaesthesia during routine health assessments were analysed for prothrombin time (PT) and activated partial thromboplastin time (aPTT) using a point-of-care analyser (POC) (Abaxis VSPro®). The wallabies had an aPTT mean of 78.09 s and median of 78.1 s. The PT for all wallabies was greater than 35 s, exceeding the longest time measured on the POC. Although PT was significantly longer, aPTT was similar to the manufacturer's domestic canine reference range. PMID:27671083

  19. Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in patients with atrial fibrillation.

    PubMed

    Okubo, Kenji; Kuwahara, Taishi; Takagi, Katsumasa; Takigawa, Masateru; Nakajima, Jun; Watari, Yuji; Nakashima, Emiko; Yamao, Kazuya; Fujino, Tadashi; Tsutsui, Hiroyuki; Takahashi, Atsushi

    2015-06-15

    Dabigatran is a direct thrombin inhibitor that has been approved for preventing stroke in patients with atrial fibrillation. In this study, we aimed to assess the associations between the dabigatran concentration (calculated through plasma-diluted thrombin time, as assessed using the Hemoclot assay) and the activated partial thromboplastin time (aPTT) and activated clotting time (ACT). We recruited 137 patients with atrial fibrillation who were receiving a normal dose of dabigatran (300 mg/d) or a reduced dose of dabigatran (220 mg/d, usually administered to patients who were elderly, had moderate renal dysfunction, or who were also receiving verapamil). We then assessed the aPTT, ACT, and Hemoclot results of the patients and calculated the plasma dabigatran concentration. The mean plasma concentration of dabigatran was 127 ± 88 ng/ml, although no significant differences in dabigatran concentration, ACT, or aPTT were observed when we compared the 2 doses of dabigatran (300 or 220 mg/d). The dabigatran concentration was within the therapeutic levels in most patients, although a high value (>300 ng/ml) was observed in several patients, which indicated a high risk of bleeding. The dabigatran concentration was strongly and positively correlated with ACT and aPTT (r = 0.87, p <0.001; and r = 0.76, p <0.001; respectively). Multivariate analysis revealed that verapamil use was independently associated with elevated dabigatran concentrations (p <0.001). Therefore, ACT and aPTT may be useful for bedside assessment of the anticoagulant activity of dabigatran, and verapamil use may be a risk factor for elevated dabigatran concentrations.

  20. /sup 111/In-labeled platelets: effects of heparin on uptake by venous thrombi and relationship to the activated partial thromboplastin time

    SciTech Connect

    Fedullo, P.F.; Moser, K.M.; Moser, K.S.; Konopka, R.; Hartman, M.T.

    1982-09-01

    The goal of heparin therapy in deep vein thrombosis is to prevent thrombus extension. The relationship between thrombus extension and the results of coagulation tests used to monitor heparin therapy is unclear. To explore this relationship, we studied the effect of several heparin regimens on the accretion of /sup 111/In-labeled platelets on fresh venous thrombi, as detected by gamma imaging, and monitored the activated partial thromboplastin time (APTT). Six dogs were treated with a 300-U/kg bolus of heparin followed by a 90-U/kg/hour heparin infusion, a dose of heparin sufficient to increase the APTT to levels greater than eight times baseline (APTT ratio); platelet accretion (thrombus imaging) occurred only after the heparin effect was reversed with protamine sulfate. Nineteen dogs were treated with a 150-U/kg bolus of heparin followed by a 4-hour, 45-U/kg/hour heparin infusion; a thrombus was demonstrated only after protamine injection in 12 (mean APTT ratio 1.3 +/- 0.19) and before protamine injection in seven. In thirteen of these 19 dogs, 30 minutes separated the platelet injection from heparin therapy, while in six this duration was less than 30 minutes. In four of these six dogs, thrombi were demonstrated before protamine therapy and at APTT ratios greater than 3.0. Finally, 10 dogs were treated with a 100-U/kg bolus followed by a 3-hour, 50-U/kg/hour heparin infusion, after which the APTT was allowed to return to baseline values spontaneously. In all 10 dogs, a thrombus was demonstrated only after cessation of the heparin infusion, and at a mean APTT ratio of 1.4 +/- 0.15 times baseline. These results suggest that, except with very early platelet injection, platelet accretion by thrombi is consistently inhibited by heparin at APTT ratios greater than 2.5. Platelet accretion by venous thrombi occurs within narrow limits of heparin effect as reflected by the APTT.

  1. Partial purification of plasma thromboplastin antecedent (factor XI) and its activation by trypsin.

    PubMed

    Saito, H; Ratnoff, O D; Marshall, J S; Pensky, J

    1973-04-01

    A persistent puzzle in our understanding of hemostasis has been the absence of hemorrhagic symptoms in the majority of patients with Hageman trait, the hereditary deficiency of Hageman factor (factor XII). One proposed hypothesis is that alternative mechanisms exist in blood through which plasma thromboplastin antecedent (PTA, factor XI) can become active in the absence of Hageman factor. In order to test this hypothesis, the effect of several proteolytic enzymes, among them thrombin, plasma kallikrein, and trypsin, was tested upon unactivated PTA. PTA was prepared from normal human plasma by Ca(3)(PO(4))(2) adsorption, ammonium sulfate fractionation, and successive chromatography on QAE-Sephadex (twice). Sephadex-G150, and SP-Sephadex. The partially purified PTA was almost all in its native form, with a specific activity of 45-70 U/mg protein; the yield was about 10%. It contained no measurable amounts of other known clotting factors, plasmin, plasminogen, nor IgG. Incubation of PTA with trypsin generated potent clot-promoting activity that corrected the abnormally long clotting time of plasma deficient in Hageman factor or PTA but not in Christmas factor. This clot-promoting agent behaved like activated PTA on gel filtration (apparent molecular weight: 185,000) and was specifically inhibited by an antiserum directed against activated PTA. These data suggested that PTA can be converted into its active form by trypsin. PTA was not activated by thrombin, chymotrypsin, papain, ficin, plasmin, plasma kallikrein, tissue thromboplastin, or C. Trypsin converted PTA to its active form enzymatically. Whether trypsin serves to activate PTA in vivo is not yet clear.

  2. 21 CFR 864.7925 - Partial thromboplastin time tests.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... screening for coagulation abnormalities, for evaluation of the effect of therapy on procoagulant disorders, and as an assay for coagulation factor deficiencies of the intrinsic coagulation pathway....

  3. 21 CFR 864.7925 - Partial thromboplastin time tests.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... screening for coagulation abnormalities, for evaluation of the effect of therapy on procoagulant disorders, and as an assay for coagulation factor deficiencies of the intrinsic coagulation pathway....

  4. 21 CFR 864.7925 - Partial thromboplastin time tests.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... screening for coagulation abnormalities, for evaluation of the effect of therapy on procoagulant disorders, and as an assay for coagulation factor deficiencies of the intrinsic coagulation pathway....

  5. 21 CFR 864.7925 - Partial thromboplastin time tests.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... screening for coagulation abnormalities, for evaluation of the effect of therapy on procoagulant disorders, and as an assay for coagulation factor deficiencies of the intrinsic coagulation pathway....

  6. 21 CFR 864.7925 - Partial thromboplastin time tests.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... screening for coagulation abnormalities, for evaluation of the effect of therapy on procoagulant disorders, and as an assay for coagulation factor deficiencies of the intrinsic coagulation pathway....

  7. Alternative pathways of thromboplastin-dependent activation of human factor X in plasma

    SciTech Connect

    Marlar, R.A.; Griffin, J.H.

    1981-01-01

    To determine the interrelationships of the major coagulation pathways, the activation of 3H-labeled factor X in normal and various deficient human plasmas was evaluated when clotting was triggered by dilute rabbit or human thromboplastin. Various dilutions of thromboplastin and calcium were added to plasma samples containing 3H-factor X, and the time course of factor X activation was determined. At a 1/250 dilution of rabbit brain thromboplastin, the rate of factor X activation in plasmas deficient in factor VIII or factor IX was 10% of the activation rate of normal plasma or of factor XI deficient plasma. Reconstitution of the deficient plasmas with factors VIII or IX, respectively, reconstituted normal factor X activation. Similar results were obtained when various dilutions of human thromboplastin replaced the rabbit thromboplastin. From these plasma experiments, it is inferred that the dilute thromboplastin-dependent activation of factor X requires factors VII, IX, and VIII. An alternative extrinsic pathway that involves factors IX and VIII may be the physiologic extrinsic pathway and hence help to explain the consistent clinical observations of bleeding diatheses in patients deficient in factors IX or VIII.

  8. A comparison of five commercial thromboplastins: ISI re-evaluation on an automated coagulometer.

    PubMed

    Ford, K; McArdle, B; Kesteven, P J

    1995-03-01

    Five commercial rabbit brain thromboplastins were compared with an International Reference Preparation on an ACL coagulometer, using 90 patients stabilized on warfarin and 22 normal individuals. The prothrombin times were converted to INRs using the thromboplastin manufacturers' quoted ISI. The quoted ISIs were reassigned using orthogonal regression analysis and then used to recalculate INRs for patient and commercial INR control plasmas. This showed that the manufacturers' quoted ISIs and the INR control plasma results were inconsistent. With one thromboplastin the manufacturers quoted ISI changed from 1.17 to 1.05 whilst the control plasma results changed from an INR of 4.3 to an INR of 3.7 (manufacturer's INR, 3.3). In most routine laboratories ISI reassignment is not practical. We conclude that the availability of a reliable plasma calibrant is essential for the accurate calculation of INRs at a local level.

  9. Partial spectral analysis of hydrological time series

    NASA Astrophysics Data System (ADS)

    Jukić, D.; Denić-Jukić, V.

    2011-03-01

    SummaryHydrological time series comprise the influences of numerous processes involved in the transfer of water in hydrological cycle. It implies that an ambiguity with respect to the processes encoded in spectral and cross-spectral density functions exists. Previous studies have not paid attention adequately to this issue. Spectral and cross-spectral density functions represent the Fourier transforms of auto-covariance and cross-covariance functions. Using this basic property, the ambiguity is resolved by applying a novel approach based on the spectral representation of partial correlation. Mathematical background for partial spectral density, partial amplitude and partial phase functions is presented. The proposed functions yield the estimates of spectral density, amplitude and phase that are not affected by a controlling process. If an input-output relation is the subject of interest, antecedent and subsequent influences of the controlling process can be distinguished considering the input event as a referent point. The method is used for analyses of the relations between the rainfall, air temperature and relative humidity, as well as the influences of air temperature and relative humidity on the discharge from karst spring. Time series are collected in the catchment of the Jadro Spring located in the Dinaric karst area of Croatia.

  10. 21 CFR 864.7900 - Thromboplastin generation test.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Thromboplastin generation test. 864.7900 Section 864.7900 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages §...

  11. 21 CFR 864.7900 - Thromboplastin generation test.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Thromboplastin generation test. 864.7900 Section 864.7900 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages §...

  12. 21 CFR 864.7900 - Thromboplastin generation test.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Thromboplastin generation test. 864.7900 Section 864.7900 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages §...

  13. 21 CFR 864.7900 - Thromboplastin generation test.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Thromboplastin generation test. 864.7900 Section 864.7900 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages §...

  14. 21 CFR 864.7900 - Thromboplastin generation test.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Thromboplastin generation test. 864.7900 Section 864.7900 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages §...

  15. Towards Just-In-Time Partial Evaluation of Prolog

    NASA Astrophysics Data System (ADS)

    Bolz, Carl Friedrich; Leuschel, Michael; Rigo, Armin

    We introduce a just-in-time specializer for Prolog. Just-in-time specialization attempts to unify of the concepts and benefits of partial evaluation (PE) and just-in-time (JIT) compilation. It is a variant of PE that occurs purely at runtime, which lazily generates residual code and is constantly driven by runtime feedback.

  16. Optimal moving grids for time-dependent partial differential equations

    NASA Technical Reports Server (NTRS)

    Wathen, A. J.

    1989-01-01

    Various adaptive moving grid techniques for the numerical solution of time-dependent partial differential equations were proposed. The precise criterion for grid motion varies, but most techniques will attempt to give grids on which the solution of the partial differential equation can be well represented. Moving grids are investigated on which the solutions of the linear heat conduction and viscous Burgers' equation in one space dimension are optimally approximated. Precisely, the results of numerical calculations of optimal moving grids for piecewise linear finite element approximation of partial differential equation solutions in the least squares norm.

  17. Stable, Ultra-Low Residence Time Partial Oxidation

    DOEpatents

    Schmidt, Lanny D.; Hickman, Daniel A.

    1997-07-15

    A process for the catalytic partial oxidation of methane in gas phase at very short residence time (800,000 to 12,000,000 hr.sup.-1) by contacting a gas stream containing methane and oxygen with a metal supported catalyst, such as platinum deposited on a ceramic monolith.

  18. Effect of Timing of Surgery in Partially Injured ACLs.

    PubMed

    Li, Bin; Bai, Lunhao; Fu, Yonghui; Wang, Guangbin; He, Ming; Wang, Jiashi

    2012-05-01

    The purpose of this study was to explore the optimal timing for surgical intervention of partially injured anterior cruciate ligaments (ACL). Thirty-eight patients were divided into early (n=17) or delayed (n=21) surgery groups based on the interval between injury and surgery. Minimum follow-up was 2 years. The outcome measures used were the International Knee Documentation Committee score, Lysholm knee score, Tegner activity rating, range of motion, and arthrometer measurements. The findings of this study indicate that early surgical reconstruction of partially ruptured ACLs did not result in arthrofibrosis but may prevent secondary loosening of the intact bundles and further meniscal and chondral injury.

  19. Optimal moving grids for time-dependent partial differential equations

    NASA Technical Reports Server (NTRS)

    Wathen, A. J.

    1992-01-01

    Various adaptive moving grid techniques for the numerical solution of time-dependent partial differential equations were proposed. The precise criterion for grid motion varies, but most techniques will attempt to give grids on which the solution of the partial differential equation can be well represented. Moving grids are investigated on which the solutions of the linear heat conduction and viscous Burgers' equation in one space dimension are optimally approximated. Precisely, the results of numerical calculations of optimal moving grids for piecewise linear finite element approximation of PDE solutions in the least-squares norm are reported.

  20. No deterioration after 13 years in a stability study of a rabbit brain, plain, thromboplastin, RBT 1010, in rubber-stoppered ampoules.

    PubMed

    Stevenson, K J; Craig, S; Goodman, L; Kanyike, F B

    2004-04-01

    RBT 1010, a rabbit brain thromboplastin, plain, was prepared at the Thrombosis Reference Centre, Withington Hospital, Manchester, in 1989. The batch has been stored at -20 degrees C, in rubber-stoppered ampoules, for 13 years. The material was unchanged after this time. This was confirmed in a stability study, in which the reagent was used to test the prothrombin times of a panel of plasmas stored in liquid nitrogen, one from a normal volunteer and two from stable anticoagulated patients. RBT 1010 was also tested in calibrations, according to World Health Organization recommendations, against the reference thromboplastin preparations CRM 149S and RBT 90.

  1. A unique precipitating autoantibody against plasma thromboplastin antecedent associated with multiple apparent plasma clotting factor deficiencies in a patient with systemic lupus erythematosus.

    PubMed

    Poon, M C; Saito, H; Koopman, W J

    1984-06-01

    A 42-yr-old woman with systemic lupus erythematosus without bleeding diathesis developed a prolonged activated partial thromboplastin time that was not corrected by normal plasma. An inhibitor that acted rapidly and inactivated 0.5 U/ml plasma thromboplastin antecedent (PTA, factor XI) at a 1:200 plasma dilution was demonstrated. In addition to a low titer of PTA (less than 0.01 U/ml), plasma assayed at 20-fold dilution also showed low titers of Hageman (factor XII, 0.02 U/ml), Fletcher (plasma prekallikrein, 0.02 U/ml), and Fitzgerald (high molecular weight kininogen, less than 0.01 U/ml) factors. The titer of these factors, except PTA, returned to normal upon further plasma dilution or upon removal of the inhibitor by protein A adsorption. Thus, the inhibitor appeared to interfere with these clotting factor assays, possibly by inactivating PTA in the substrate plasmas in the test system. Its specificity was further confirmed. The inhibitor did not interfere with surface-induced proteolytic cleavage of Hageman factor. Surface-induced generation of plasma kallikrein activity (amidolysis of H-D-pro-phe-arg-pNa and cold-promoted factor VII activity enhancement) requires only Hageman, Fletcher, and Fitzgerald factors and was normal. Reactions requiring all 4 contact phase factors, including PTA, such as surface-induced generation of plasmin activity (amidolysis of H-D-val-leu-lys-pNa) and activated Christmas factor (factor IXa) activity, were defective. Furthermore, the inhibitor bound to agarose-protein A inactivated and removed PTA selectively from normal plasma. The inhibitor was an IgG-lambda autoantibody that precipitated PTA. The inactivated activated PTA (factor XIa) without the requirement for an additional cofactor. Furthermore, it inhibited surface-induced activation of PTA by interfering with its proteolytic cleavage upon glass surface exposure and with its binding onto the reactive surfaces.

  2. Monitoring oral anticoagulant treatment with the TAS near-patient test system: comparison with conventional thromboplastins.

    PubMed Central

    Kitchen, S; Preston, F E

    1997-01-01

    BACKGROUND: A number of instruments have been developed for determination of prothrombin time (PT) and International Normalised Ratio (INR) at locations not limited to central laboratories. AIM: To evaluate one such portable instrument, the Thrombolytic Assessment System (TAS), which can be used in a near-patient setting. METHODS: Samples from 20 normal subjects and 48 patients treated with warfarin for venous thromboembolic disease were studied. The warfarin group was divided into: initiation phase (n = 10), combined warfarin and heparin (n = 10), stabilised therapy (n = 20), and over anticoagulated patients (n = 8). PTs and INRs were determined in each group using three conventional thromboplastins (Diagen Activated, Manchester Reagent, and Instrumentation Laboratory) and two TAS techniques (whole blood or plasma). An independent International Sensitivity Index (ISI) calibration of the TAS system was performed. RESULTS: Calculated ISIs for the TAS were 1.028 and 0.984 for plasma and whole blood analysis, respectively, compared with manufacturer's values of 0.98 and 0.97. INR results with TAS (whole blood) were 11% less than those obtained with Diagen Activated (p < 0.01) and 16% less than those obtained with Instrumentation Laboratory (p < 0.001) when manufacturers' mean normal PT and ISI were used for TAS INRs. TAS (whole blood) results were similar to TAS plasma or Manchester Reagent results. The use of a locally determined mean normal prothrombin time (MNPT) improved agreement between TAS and the other reagents, abolishing the significant difference between INRs determined with TAS (whole blood) and Diagen Activated techniques. CONCLUSION: The TAS system can be used with whole blood or plasma and produces similar INRs to those obtained with Diagen Activated or Manchester Reagent using manufacturer's ISI and a locally determined MNPT. Results were lower with TAS or Manchester Reagent compared with those obtained with Instrumentation Laboratory thromboplastin

  3. Partial scene reconstruction using Time-of-Flight imaging

    NASA Astrophysics Data System (ADS)

    Zhang, Yuchen; Xiong, Hongkai

    2014-11-01

    This paper is devoted to generating the coordinates of partial 3D points in scene reconstruction via time of flight (ToF) images. Assuming the camera does not move, only the coordinates of the points in images are accessible. The exposure time is two trillionths of a second and the synthetic visualization shows that the light moves at half a trillion frames per second. In global light transport, direct components signify that the light is emitted from a light point and reflected from a scene point only once. Considering that the camera and source light point are supposed to be two focuses of an ellipsoid and have a constant distance at a time, we take into account both the constraints: (1) the distance is the sum of distances which light travels between the two focuses and the scene point; and (2) the focus of the camera, the scene point and the corresponding image point are in a line. It is worth mentioning that calibration is necessary to obtain the coordinates of the light point. The calibration can be done in the next two steps: (1) choose a scene that contains some pairs of points in the same depth, of which positions are known; and (2) take the positions into the last two constraints and get the coordinates of the light point. After calculating the coordinates of scene points, MeshLab is used to build the partial scene model. The proposed approach is favorable to estimate the exact distance between two scene points.

  4. Thromboplastin immobilized on polystyrene surface exhibits kinetic characteristics close to those for the native protein and activates in vitro blood coagulation similarly to thromboplastin on fibroblasts.

    PubMed

    Fadeeva, O A; Panteleev, M A; Karamzin, S S; Balandina, A N; Smirnov, I V; Ataullakhanov, F I

    2010-06-01

    A method for transmembrane protein thromboplastin (tissue factor) immobilization on polystyrene surface is described. Tissue factor is the main activating factor launching the blood coagulation process. It is a cofactor of factor VIIa, the first protease in the cascade of coagulation reactions. The proposed method preserves kinetic characteristics specific for native tissue factor on the fibroblast surface. The kinetics of binding to factor VIIa and enzymic activity of the formed complex follow Michaelis-Menten kinetics, which is also characteristic of native complex. A small difference is that dissociation constant for tissue factor immobilized on polystyrene surface exceeds 2.7-fold that for native factor. The proposed technique of immobilization provides for protein density on the activating surface corresponding to the tissue factor density on the fibroblast surface. The immobilized tissue factor can be used to activate blood coagulation in methods simulating spatial dynamics of in vitro clot growth. Investigation in this direction will make it possible to register both hypo- and hypercoagulation states of the system. This approach is advantageous over traditional methods of estimation of the coagulation system conditions, which mainly register only hypocoagulation. Investigation of the storage time has shown that activators containing immobilized tissue factor can be stored and used during for at least 100 days in the method studying spatial dynamics of fibrin clot formation.

  5. [The quality indices of the Quick method using thromboplastin reagents performed manually and instrumentally].

    PubMed

    Tarasova, L N; Vladimirova, S G; Savinykh, E Iu; Platonov, G K; Rechkin, O I

    2000-03-01

    The reproduction and results of Quick's method with tissue thromboplastin (Kirov Institute of Hematology and Blood Transfusion--KIHBT) and Excel and Excel S simplastins (Organon Teknika, Netherlands) in the tube and automated versions were compared. Semiautomated coagulometer COAG-A-MATE XM and automated COAG-A-MATE RA-4 of the same firm were used. Three Verifi plasmas (Organon Teknika) with different activities of factors II, VII, IX, and X were used. Tests with thromboplastin manufactured by KIHBT were well reproduced both in the tube and automated modifications (CV < 10%). This thromboplastin can be used for monitoring the efficiency of therapy by indirect anticoagulants. For evaluating the correlation between results, plasma samples from 21 donors and 12 patients treated by indirect anticoagulants with the prothrombin index (PI) lower than 75% were analyzed. The PI of the tube and automated modifications were in good correlation. Tests with the Russian thromboplastin showed high coefficients of correlation between the two modifications of Quick's test, which recommends the use of these device-reagent combinations for evaluation of PI.

  6. Parallelizing across time when solving time-dependent partial differential equations

    SciTech Connect

    Worley, P.H.

    1991-09-01

    The standard numerical algorithms for solving time-dependent partial differential equations (PDEs) are inherently sequential in the time direction. This paper describes algorithms for the time-accurate solution of certain classes of linear hyperbolic and parabolic PDEs that can be parallelized in both time and space and have serial complexities that are proportional to the serial complexities of the best known algorithms. The algorithms for parabolic PDEs are variants of the waveform relaxation multigrid method (WFMG) of Lubich and Ostermann where the scalar ordinary differential equations (ODEs) that make up the kernel of WFMG are solved using a cyclic reduction type algorithm. The algorithms for hyperbolic PDEs use the cyclic reduction algorithm to solve ODEs along characteristics. 43 refs.

  7. Time Parallel Solution of Linear Partial Differential Equations on the Intel Touchstone Delta Supercomputer

    NASA Technical Reports Server (NTRS)

    Toomarian, N.; Fijany, A.; Barhen, J.

    1993-01-01

    Evolutionary partial differential equations are usually solved by decretization in time and space, and by applying a marching in time procedure to data and algorithms potentially parallelized in the spatial domain.

  8. Imprecise results: Utilizing partial computations in real-time systems

    NASA Technical Reports Server (NTRS)

    Lin, Kwei-Jay; Natarajan, Swaminathan; Liu, Jane W.-S.

    1987-01-01

    In real-time systems, a computation may not have time to complete its execution because of deadline requirements. In such cases, no result except the approximate results produced by the computations up to that point will be available. It is desirable to utilize these imprecise results if possible. Two approaches are proposed to enable computations to return imprecise results when executions cannot be completed normally. The milestone approach records results periodically, and if a deadline is reached, returns the last recorded result. The sieve approach demarcates sections of code which can be skipped if the time available is insufficient. By using these approaches, the system is able to produce imprecise results when deadlines are reached. The design of the Concord project is described which supports imprecise computations using these techniques. Also presented is a general model of imprecise computations using these techniques, as well as one which takes into account the influence of the environment, showing where the latter approach fits into this model.

  9. 19 CFR 158.12 - Merchandise partially damaged at time of importation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... duties for partial damage or loss in consequence of discoloration or rust occurring before importation... damaged at the time of importation, no allowance may be made in the specific duties or in the...

  10. 19 CFR 158.12 - Merchandise partially damaged at time of importation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... duties for partial damage or loss in consequence of discoloration or rust occurring before importation... damaged at the time of importation, no allowance may be made in the specific duties or in the...

  11. Multi-input partial eigenvalue assignment for high order control systems with time delay

    NASA Astrophysics Data System (ADS)

    Zhang, Lei

    2016-05-01

    In this paper, we consider the partial eigenvalue assignment problem for high order control systems with time delay. Ram et al. (2011) [1] have shown that a hybrid method can be used to solve partial quadratic eigenvalue assignment problem of single-input vibratory system. Based on this theory, a rather simple algorithm for solving multi-input partial eigenvalue assignment for high order control systems with time delay is proposed. Our method can assign the expected eigenvalues and keep the no spillover property. The solution can be implemented with only partial information of the eigenvalues and the corresponding eigenvectors of the matrix polynomial. Numerical examples are given to illustrate the efficiency of our approach.

  12. Synchronization and Partial Synchronization Experiments with Networks of Time-Delay Coupled Hindmarsh-Rose Neurons

    NASA Astrophysics Data System (ADS)

    Steur, Erik; Murguia, Carlos; Fey, Rob H. B.; Nijmeijer, Henk

    2016-06-01

    We study experimentally synchronization and partial synchronization in networks of Hindmarsh-Rose model neurons that interact through linear time-delay couplings. Our experimental setup consists of electric circuit board realizations of the Hindmarsh-Rose model neuron and a coupling interface in which the interaction between the circuits is defined. With this experimental setup we test the predictive value of theoretical results about synchronization and partial synchronization in networks.

  13. New Solutions of Three Nonlinear Space- and Time-Fractional Partial Differential Equations in Mathematical Physics

    NASA Astrophysics Data System (ADS)

    Yao, Ruo-Xia; Wang, Wei; Chen, Ting-Hua

    2014-11-01

    Motivated by the widely used ansätz method and starting from the modified Riemann—Liouville derivative together with a fractional complex transformation that can be utilized to transform nonlinear fractional partial differential equations to nonlinear ordinary differential equations, new types of exact traveling wave solutions to three important nonlinear space- and time-fractional partial differential equations are obtained simultaneously in terms of solutions of a Riccati equation. The results are new and first reported in this paper.

  14. Graphic processing unit accelerated real-time partially coherent beam generator

    NASA Astrophysics Data System (ADS)

    Ni, Xiaolong; Liu, Zhi; Chen, Chunyi; Jiang, Huilin; Fang, Hanhan; Song, Lujun; Zhang, Su

    2016-07-01

    A method of using liquid-crystals (LCs) to generate a partially coherent beam in real-time is described. An expression for generating a partially coherent beam is given and calculated using a graphic processing unit (GPU), i.e., the GeForce GTX 680. A liquid-crystal on silicon (LCOS) with 256 × 256 pixels is used as the partially coherent beam generator (PCBG). An optimizing method with partition convolution is used to improve the generating speed of our LC PCBG. The total time needed to generate a random phase map with a coherence width range from 0.015 mm to 1.5 mm is less than 2.4 ms for calculation and readout with the GPU; adding the time needed for the CPU to read and send to LCOS with the response time of the LC PCBG, the real-time partially coherent beam (PCB) generation frequency of our LC PCBG is up to 312 Hz. To our knowledge, it is the first real-time partially coherent beam generator. A series of experiments based on double pinhole interference are performed. The result shows that to generate a laser beam with a coherence width of 0.9 mm and 1.5 mm, with a mean error of approximately 1%, the RMS values needed 0.021306 and 0.020883 and the PV values required 0.073576 and 0.072998, respectively.

  15. A Comparison of Momentary Time Sampling and Partial-Interval Recording for Evaluating Functional Relations

    ERIC Educational Resources Information Center

    Meany-Daboul, Maeve G.; Roscoe, Eileen M.; Bourret, Jason C.; Ahearn, William H.

    2007-01-01

    In the current study, momentary time sampling (MTS) and partial-interval recording (PIR) were compared to continuous-duration recording of stereotypy and to the frequency of self-injury during a treatment analysis to determine whether the recording method affected data interpretation. Five previously conducted treatment analysis data sets were…

  16. 19 CFR 158.12 - Merchandise partially damaged at time of importation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Merchandise partially damaged at time of importation. 158.12 Section 158.12 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) RELIEF FROM DUTIES ON MERCHANDISE LOST, DAMAGED, ABANDONED, OR EXPORTED Damaged or...

  17. Measuring Safety Performance: A Comparison of Whole, Partial, and Momentary Time-Sampling Recording Methods

    ERIC Educational Resources Information Center

    Alvero, Alicia M.; Struss, Kristen; Rappaport, Eva

    2008-01-01

    Partial-interval (PIR), whole-interval (WIR), and momentary time sampling (MTS) estimates were compared against continuous measures of safety performance for three postural behaviors: feet, back, and shoulder position. Twenty-five samples of safety performance across five undergraduate students were scored using a second-by-second continuous…

  18. Combining Instruction Prefetching with Partial Cache Locking to Improve WCET in Real-Time Systems

    PubMed Central

    Ni, Fan; Long, Xiang; Wan, Han; Gao, Xiaopeng

    2013-01-01

    Caches play an important role in embedded systems to bridge the performance gap between fast processor and slow memory. And prefetching mechanisms are proposed to further improve the cache performance. While in real-time systems, the application of caches complicates the Worst-Case Execution Time (WCET) analysis due to its unpredictable behavior. Modern embedded processors often equip locking mechanism to improve timing predictability of the instruction cache. However, locking the whole cache may degrade the cache performance and increase the WCET of the real-time application. In this paper, we proposed an instruction-prefetching combined partial cache locking mechanism, which combines an instruction prefetching mechanism (termed as BBIP) with partial cache locking to improve the WCET estimates of real-time applications. BBIP is an instruction prefetching mechanism we have already proposed to improve the worst-case cache performance and in turn the worst-case execution time. The estimations on typical real-time applications show that the partial cache locking mechanism shows remarkable WCET improvement over static analysis and full cache locking. PMID:24386133

  19. Underwater partial polarization signatures from the shallow water real-time imaging polarimeter (SHRIMP)

    NASA Astrophysics Data System (ADS)

    Taylor, James S., Jr.; Davis, P. S.; Wolff, Lawrence B.

    2003-09-01

    Research has shown that naturally occurring light outdoors and underwater is partially linearly polarized. The polarized components can be combined to form an image that describes the polarization of the light in the scene. This image is known as the degree of linear polarization (DOLP) image or partial polarization image. These naturally occurring polarization signatures can provide a diver or an unmanned underwater vehicle (UUV) with more information to detect, classify, and identify threats such as obstacles and/or mines in the shallow water environment. The SHallow water Real-time IMaging Polarimeter (SHRIMP), recently developed under sponsorship of Dr. Tom Swean at the Office of Naval Research (Code 321OE), can measure underwater partial polarization imagery. This sensor is a passive, three-channel device that simultaneously measures the three components of the Stokes vector needed to determine the partial linear polarization of the scene. The testing of this sensor has been completed and the data has been analyzed. This paper presents performance results from the field-testing and quantifies the gain provided by the partial polarization signature of targets in the Very Shallow Water (VSW) and Surf Zone (SZ) regions.

  20. Partial mixture model for tight clustering of gene expression time-course

    PubMed Central

    Yuan, Yinyin; Li, Chang-Tsun; Wilson, Roland

    2008-01-01

    Background Tight clustering arose recently from a desire to obtain tighter and potentially more informative clusters in gene expression studies. Scattered genes with relatively loose correlations should be excluded from the clusters. However, in the literature there is little work dedicated to this area of research. On the other hand, there has been extensive use of maximum likelihood techniques for model parameter estimation. By contrast, the minimum distance estimator has been largely ignored. Results In this paper we show the inherent robustness of the minimum distance estimator that makes it a powerful tool for parameter estimation in model-based time-course clustering. To apply minimum distance estimation, a partial mixture model that can naturally incorporate replicate information and allow scattered genes is formulated. We provide experimental results of simulated data fitting, where the minimum distance estimator demonstrates superior performance to the maximum likelihood estimator. Both biological and statistical validations are conducted on a simulated dataset and two real gene expression datasets. Our proposed partial regression clustering algorithm scores top in Gene Ontology driven evaluation, in comparison with four other popular clustering algorithms. Conclusion For the first time partial mixture model is successfully extended to time-course data analysis. The robustness of our partial regression clustering algorithm proves the suitability of the combination of both partial mixture model and minimum distance estimator in this field. We show that tight clustering not only is capable to generate more profound understanding of the dataset under study well in accordance to established biological knowledge, but also presents interesting new hypotheses during interpretation of clustering results. In particular, we provide biological evidences that scattered genes can be relevant and are interesting subjects for study, in contrast to prevailing opinion

  1. EMPIRICAL LIKELIHOOD INFERENCE FOR THE COX MODEL WITH TIME-DEPENDENT COEFFICIENTS VIA LOCAL PARTIAL LIKELIHOOD

    PubMed Central

    Sun, Yanqing; Sundaram, Rajeshwari; Zhao, Yichuan

    2009-01-01

    The Cox model with time-dependent coefficients has been studied by a number of authors recently. In this paper, we develop empirical likelihood (EL) pointwise confidence regions for the time-dependent regression coefficients via local partial likelihood smoothing. The EL simultaneous confidence bands for a linear combination of the coefficients are also derived based on the strong approximation methods. The empirical likelihood ratio is formulated through the local partial log-likelihood for the regression coefficient functions. Our numerical studies indicate that the EL pointwise/simultaneous confidence regions/bands have satisfactory finite sample performances. Compared with the confidence regions derived directly based on the asymptotic normal distribution of the local constant estimator, the EL confidence regions are overall tighter and can better capture the curvature of the underlying regression coefficient functions. Two data sets, the gastric cancer data and the Mayo Clinic primary biliary cirrhosis data, are analyzed using the proposed method. PMID:19838322

  2. Constructing and predicting solitary pattern solutions for nonlinear time-fractional dispersive partial differential equations

    NASA Astrophysics Data System (ADS)

    Arqub, Omar Abu; El-Ajou, Ahmad; Momani, Shaher

    2015-07-01

    Building fractional mathematical models for specific phenomena and developing numerical or analytical solutions for these fractional mathematical models are crucial issues in mathematics, physics, and engineering. In this work, a new analytical technique for constructing and predicting solitary pattern solutions of time-fractional dispersive partial differential equations is proposed based on the generalized Taylor series formula and residual error function. The new approach provides solutions in the form of a rapidly convergent series with easily computable components using symbolic computation software. For method evaluation and validation, the proposed technique was applied to three different models and compared with some of the well-known methods. The resultant simulations clearly demonstrate the superiority and potentiality of the proposed technique in terms of the quality performance and accuracy of substructure preservation in the construct, as well as the prediction of solitary pattern solutions for time-fractional dispersive partial differential equations.

  3. Numerical methods for large-scale, time-dependent partial differential equations

    NASA Technical Reports Server (NTRS)

    Turkel, E.

    1979-01-01

    A survey of numerical methods for time dependent partial differential equations is presented. The emphasis is on practical applications to large scale problems. A discussion of new developments in high order methods and moving grids is given. The importance of boundary conditions is stressed for both internal and external flows. A description of implicit methods is presented including generalizations to multidimensions. Shocks, aerodynamics, meteorology, plasma physics and combustion applications are also briefly described.

  4. A New Mixed Element Method for a Class of Time-Fractional Partial Differential Equations

    PubMed Central

    Li, Hong; Gao, Wei; He, Siriguleng; Fang, Zhichao

    2014-01-01

    A kind of new mixed element method for time-fractional partial differential equations is studied. The Caputo-fractional derivative of time direction is approximated by two-step difference method and the spatial direction is discretized by a new mixed element method, whose gradient belongs to the simple (L2(Ω)2) space replacing the complex H(div; Ω) space. Some a priori error estimates in L2-norm for the scalar unknown u and in (L2)2-norm for its gradient σ. Moreover, we also discuss a priori error estimates in H1-norm for the scalar unknown u. PMID:24737957

  5. Spectral methods in time for a class of parabolic partial differential equations

    SciTech Connect

    Ierley, G. ); Spencer, B. ); Worthing, R. )

    1992-09-01

    In this paper, we introduce a fully spectral solution for the partial differential equation u[sub t] + uu[sub x] + vu[sub xx] + [mu]u[sub xxx] + [lambda]u[sub xxxx] = O. For periodic boundary conditions in space, the use of a Fourier expansion in x admits of a particularly efficient algorithm with respect to expansion of the time dependence in a Chebyshev series. Boundary conditions other than periodic may still be treated with reasonable, though lesser, efficiency. for all cases, very high accuracy is attainable at moderate computational cost relative to the expense of variable order finite difference methods in time. 14 refs., 9 figs.

  6. Computationally Efficient Partial Crosstalk Cancellation in Fast Time-Varying DSL Crosstalk Environments

    NASA Astrophysics Data System (ADS)

    Forouzan, Amir R.; Garth, Lee M.

    2007-12-01

    Line selection (LS), tone selection (TS), and joint tone-line selection (JTLS) partial crosstalk cancellers have been proposed to reduce the online computational complexity of far-end crosstalk (FEXT) cancellers in digital subscriber lines (DSL). However, when the crosstalk profile changes rapidly over time, there is an additional requirement that the partial crosstalk cancellers, particularly the LS and JTLS schemes, should also provide a low preprocessing complexity. This is in contrast to the case for perfect crosstalk cancellers. In this paper, we propose two novel channel matrix inversion methods, the approximate inverse (AI) and reduced inverse (RI) schemes, which reduce the recurrent complexity of the LS and JTLS schemes. Moreover, we propose two new classes of JTLS algorithms, the subsort and Lagrange JTLS algorithms, with significantly lower computational complexity than the recently proposed optimal greedy JTLS scheme. The computational complexity analysis of our algorithms shows that they provide much lower recurrent complexities than the greedy JTLS algorithm, allowing them to work efficiently in very fast time-varying crosstalk environments. Moreover, the analytical and simulation results demonstrate that our techniques are close to the optimal solution from the crosstalk cancellation point of view. The results also reveal that partial crosstalk cancellation is more beneficial in upstream DSL, particularly for short loops.

  7. Imaging objects behind a partially reflective surface with a modified time-of-flight sensor

    NASA Astrophysics Data System (ADS)

    Geerardyn, D.; Kuijk, M.

    2014-05-01

    Time-of-Flight (ToF) methods are used in different applications for depth measurements. There are mainly 2 types of ToF measurements, Pulsed Time-of-Flight and Continuous-Wave Time-of-Flight. Pulsed Time-of-Flight (PToF) techniques are mostly used in combination with a scanning mirror, which makes them not well suited for imaging purposes. Continuous-wave Time-of-Flight (CWToF) techniques are mostly used wide-field, hence they are much faster and more suited for imaging purposes but cannot be used behind partially-reflective surfaces. In commercial applications, both ToF methods require specific hardware, which cannot be exchanged. In this paper, we discuss the transformation of a CWToF sensor to a PToF camera, which is able to make images and measure the distances of objects behind a partially-reflective surface, like the air-water interface in swimming pools when looking from above. We first created our own depth camera which is suitable for both CWToF and PToF. We describe the necessary hardware components for a normal ToF camera and compare it with the adapted components which make it a range-gating depth imager. Afterwards, we modeled the distances and images of one or more objects positioned behind a partially-reflective surface and combine it with measurement data of the optical pulse. A scene was virtualized and the rays from a raytracing software tool were exported to Matlab™. Subsequently, pulse deformations were calculated for every pixel, which resulted in the calculation of the depth information.

  8. Partial eigenvalue assignment and its stability in a time delayed system

    NASA Astrophysics Data System (ADS)

    Singh, Kumar V.; Dey, Rajeeb; Datta, Biswa N.

    2014-01-01

    Active vibration control strategy is an effective way to control dangerous vibrations in a structure, caused by resonance and to manipulate the dynamics of vibrational response. Implementation of this strategy requires real-time computations of two feedback control matrices such that a small amount of eigenvalues of the associated quadratic matrix pencil are replaced by suitably chosen ones while the remaining large number of eigenvalues and eigenvectors remain unchanged ensuring the no spill-over. This mathematical problem is referred to as the Quadratic Partial Eigenvalue Assignment problem. The greatest challenge there is to solve the problems using the knowledge of only a small number of eigenvalues and eigenvectors that are computable using state-of-the-art techniques. This paper generalizes the earlier work on partial assignment to constant time-delay systems. Furthermore, a posterior stability analysis is carried out to identify the ranges of the time-delay that maintains the closed-loop assignment while keeping the stability of the infinite number of eigenvalues for the time-delayed systems. The practical features of the proposed methods are that it is implemented in the second-order setting itself using only those small number of eigenvalues and the eigenvectors that are to be assigned and the no spill-over is established by means of mathematical results. The results of our numerical experiments support the validity of our proposed methods.

  9. Detrended partial cross-correlation analysis of two nonstationary time series influenced by common external forces

    NASA Astrophysics Data System (ADS)

    Qian, Xi-Yuan; Liu, Ya-Min; Jiang, Zhi-Qiang; Podobnik, Boris; Zhou, Wei-Xing; Stanley, H. Eugene

    2015-06-01

    When common factors strongly influence two power-law cross-correlated time series recorded in complex natural or social systems, using detrended cross-correlation analysis (DCCA) without considering these common factors will bias the results. We use detrended partial cross-correlation analysis (DPXA) to uncover the intrinsic power-law cross correlations between two simultaneously recorded time series in the presence of nonstationarity after removing the effects of other time series acting as common forces. The DPXA method is a generalization of the detrended cross-correlation analysis that takes into account partial correlation analysis. We demonstrate the method by using bivariate fractional Brownian motions contaminated with a fractional Brownian motion. We find that the DPXA is able to recover the analytical cross Hurst indices, and thus the multiscale DPXA coefficients are a viable alternative to the conventional cross-correlation coefficient. We demonstrate the advantage of the DPXA coefficients over the DCCA coefficients by analyzing contaminated bivariate fractional Brownian motions. We calculate the DPXA coefficients and use them to extract the intrinsic cross correlation between crude oil and gold futures by taking into consideration the impact of the U.S. dollar index. We develop the multifractal DPXA (MF-DPXA) method in order to generalize the DPXA method and investigate multifractal time series. We analyze multifractal binomial measures masked with strong white noises and find that the MF-DPXA method quantifies the hidden multifractal nature while the multifractal DCCA method fails.

  10. Partial state and unknown input estimation for time-delay systems

    NASA Astrophysics Data System (ADS)

    Teh, P. S.; Trinh, H.

    2012-04-01

    This article considers the problem of estimating a partial set of the state vector and/or unknown input vector of linear systems driven by unknown inputs and time-varying delay in the state variables. Three types of reduced-order observers, namely, observers with delays, observers without internal delays and delay-free observers are proposed in this article. Existence conditions and design procedures are presented for the determination of parameters for each case of observers. Numerical examples are presented to illustrate the design procedures.

  11. Time-variant partial directed coherence in analysis of the cardiovascular system. A methodological study.

    PubMed

    Milde, T; Schwab, K; Walther, M; Eiselt, M; Schelenz, C; Voss, A; Witte, H

    2011-11-01

    Time-variant partial directed coherence (tvPDC) is used for the first time in a multivariate analysis of heart rate variability (HRV), respiratory movements (RMs) and (systolic) arterial blood pressure. It is shown that respiration-related HRV components which also occur at other frequencies besides the RM frequency (= respiratory sinus arrhythmia, RSA) can be identified. These additional components are known to be an effect of the 'half-the-mean-heart-rate-dilemma' ('cardiac aliasing' CA). These CA components may contaminate the entire frequency range of HRV and can lead to misinterpretation of the RSA analysis. TvPDC analysis of simulated and clinical data (full-term neonates and sedated patients) reveals these contamination effects and, in addition, the respiration-related CA components can be separated from the RSA component and the Traube-Hering-Mayer wave. It can be concluded that tvPDC can be beneficially applied to avoid misinterpretations in HRV analyses as well as to quantify partial correlative interaction properties between RM and RSA.

  12. Estimating the time and temperature relationship for causation of deep-partial thickness skin burns.

    PubMed

    Abraham, John P; Plourde, Brian; Vallez, Lauren; Stark, John; Diller, Kenneth R

    2015-12-01

    The objective of this study is to develop and present a simple procedure for evaluating the temperature and exposure-time conditions that lead to causation of a deep-partial thickness burn and the effect that the immediate post-burn thermal environment can have on the process. A computational model has been designed and applied to predict the time required for skin burns to reach a deep-partial thickness level of injury. The model includes multiple tissue layers including the epidermis, dermis, hypodermis, and subcutaneous tissue. Simulated exposure temperatures ranged from 62.8 to 87.8°C (145-190°F). Two scenarios were investigated. The first and worst case scenario was a direct exposure to water (characterized by a large convection coefficient) with the clothing left on the skin following the exposure. A second case consisted of a scald insult followed immediately by the skin being washed with cool water (20°C). For both cases, an Arrhenius injury model was applied whereby the extent and depth of injury were calculated and compared for the different post-burn treatments. In addition, injury values were compared with experiment data from the literature to assess verification of the numerical methodology. It was found that the clinical observations of injury extent agreed with the calculated values. Furthermore, inundation with cool water decreased skin temperatures more quickly than the clothing insulating case and led to a modest decrease in the burn extent.

  13. Partial state estimation for linear systems with output and input time delays.

    PubMed

    Ha, Q P; That, Nguyen D; Nam, Phan T; Trinh, H

    2014-03-01

    This paper deals with the problem of partial state observer design for linear systems that are subject to time delays in the measured output as well as the control input. By choosing a set of appropriate augmented Lyapunov-Krasovskii functionals with a triple-integral term and using the information of both the delayed output and input, a novel approach to design a minimal-order observer is proposed to guarantee that the observer error is ε-convergent with an exponential rate. Existence conditions of such an observer are derived in terms of matrix inequalities for the cases with time delays in both the output and input and with output delay only. Constructive design algorithms are introduced. Numerical examples are provided to illustrate the design procedure, practicality and effectiveness of the proposed observer.

  14. Evaluation of partial k-space strategies to speed up time-domain EPR imaging.

    PubMed

    Subramanian, Sankaran; Chandramouli, Gadisetti V R; McMillan, Alan; Gullapalli, Rao P; Devasahayam, Nallathamby; Mitchell, James B; Matsumoto, Shingo; Krishna, Murali C

    2013-09-01

    Narrow-line spin probes derived from the trityl radical have led to the development of fast in vivo time-domain EPR imaging. Pure phase-encoding imaging modalities based on the single-point imaging scheme have demonstrated the feasibility of three-dimensional oximetric images with functional information in minutes. In this article, we explore techniques to improve the temporal resolution and circumvent the relatively short biological half-lives of trityl probes using partial k-space strategies. There are two main approaches: one involves the use of the Hermitian character of the k-space by which only part of the k-space is measured and the unmeasured part is generated using the Hermitian symmetry. This approach is limited in success by the accuracy of numerical estimate of the phase roll in the k-space that corrupts the Hermiticy. The other approach is to measure only a judicially chosen reduced region of k-space (a centrosymmetric ellipsoid region) that more or less accounts for >70% of the k-space energy. Both of these aspects were explored in Fourier transform-EPR imaging with a doubling of scan speed demonstrated by considering ellipsoid geometry of the k-space. Partial k-space strategies help improve the temporal resolution in studying fast dynamics of functional aspects in vivo with infused spin probes.

  15. A frequency domain method for the generation of partially coherent normal stationary time domain signals

    SciTech Connect

    Smallwood, D.O.; Paez, T.L.

    1991-01-01

    A procedure for generating vectors of time domain signals which are partially coherent in a prescribed manner is described. The procedure starts with the spectral density matrix, (G{sub xx}(f)), that relates pairs of elements of the vector random process (x(t), {minus}{infinity} < t < {infinity}). The spectral density matrix is decomposed into the form (G{sub xx}(f)) = (U(f)) (S(f)) (U(f)){prime} where (U(f)) is a matrix of complex frequency response functions, and (S(f)) is a diagonal matrix of real functions which can vary with frequency. The factors of the spectral density matrix, (U(f)) and (S(f)), are then used to generate a frame of random data in the frequency domain. The data is transformed into the time domain using an inverse FFT to generate a frame of data in the time domain. Successive frames of data are then windowed, overlapped, and added to form a vector of normal stationary sampled time histories, (x(t)), of arbitrary length. 11 refs., 4 figs., 1 tab.

  16. Measuring time-varying information flow in scalp EEG signals: orthogonalized partial directed coherence.

    PubMed

    Omidvarnia, Amir; Azemi, Ghasem; Boashash, Boualem; O'Toole, John M; Colditz, Paul B; Vanhatalo, Sampsa

    2014-03-01

    This study aimed to develop a time-frequency method for measuring directional interactions over time and frequency from scalp-recorded electroencephalographic (EEG) signals in a way that is less affected by volume conduction and amplitude scaling. We modified the time-varying generalized partial directed coherence (tv-gPDC) method, by orthogonalization of the strictly causal multivariate autoregressive model coefficients, to minimize the effect of mutual sources. The novel measure, generalized orthogonalized PDC (gOPDC), was tested first using two simulated models with feature dimensions relevant to EEG activities. We then used the method for assessing event-related directional information flow from flash-evoked responses in neonatal EEG. For testing statistical significance of the findings, we followed a thresholding procedure driven by baseline periods in the same EEG activity. The results suggest that the gOPDC method 1) is able to remove common components akin to volume conduction effect in the scalp EEG, 2) handles the potential challenge with different amplitude scaling within multichannel signals, and 3) can detect directed information flow within a subsecond time scale in nonstationary multichannel EEG datasets. This method holds promise for estimating directed interactions between scalp EEG channels that are commonly affected by the confounding impact of mutual cortical sources.

  17. A comparison of momentary time sampling and partial-interval recording for evaluating functional relations.

    PubMed

    Meany-Daboul, Maeve G; Roscoe, Eileen M; Bourret, Jason C; Ahearn, William H

    2007-01-01

    In the current study, momentary time sampling (MTS) and partial-interval recording (PIR) were compared to continuous-duration recording of stereotypy and to the frequency of self-injury during a treatment analysis to determine whether the recording method affected data interpretation. Five previously conducted treatment analysis data sets were analyzed by creating separate graphic displays for each measurement method (duration or frequency, MTS, and PIR). An expert panel interview and structured criterion visual inspection were used to evaluate treatment effects across measurement methods. Results showed that treatment analysis interpretations based on both discontinuous recording methods often matched those based on frequency or duration recording; however, interpretations based on MTS were slightly more likely to match those based on duration and those based on PIR were slightly more likely to match those based on frequency.

  18. Point-of-care monitoring of oral anticoagulation therapy in children. Comparison of the CoaguChek XS system with venous INR and venous INR using an International Reference Thromboplastin preparation (rTF/95).

    PubMed

    Greenway, Anthea; Ignjatovic, Vera; Summerhayes, Robyn; Newall, Fiona; Burgess, Janet; DeRosa, Lydia; Monagle, Paul

    2009-07-01

    Point-of-care (POC) monitoring of oral anticoagulation has been widely adopted in both paediatric and adult patients. A new POC system, the CoaguChek XS has recently been developed to measure the international normalised ratio (INR) and may offer significant advantages. The CoaguChek XS utilises a new method of electrochemical clot detection based on thrombin generation. This system has not been previously evaluated in children with reference to the laboratory gold standard, the prothrombin time using reference thromboplastin. It was the objective to compare values obtained by the CoaguChek XS system with both the venous INR and the gold standard for anticoagulant monitoring, prothrombin time with reference thromboplastin (rTF/95). To evaluate the impact of testing using the CoaguChek XS on clinical anticoagulant dosing decisions. Fifty paired venous INR and capillary CoaguChek XS results were obtained from 31 children (aged up to 16 years). The laboratory gold standard, a manual prothrombin time with reference thromboplastin (rTF/95) was additionally performed on 26 samples. Correlation between the CoaguChek XS result and the venous INR was r = 0.810. Agreement between the CoaguChek XS result and the reference INR was shown to be higher (r=0.95), in the subset analysed by this method. Correlation between the venous INR and reference INR was r=0.90. Despite changes to the methodology of testing with the CoaguChek XS POC monitoring system, the accuracy of this method when compared with both the venous INR and gold standard reference INR was satisfactory. This resulted in infrequent changes to clinical decision making regarding anticoagulation.

  19. Multiparental Mapping of Plant Height and Flowering Time QTL in Partially Isogenic Sorghum Families

    PubMed Central

    Higgins, R. H.; Thurber, C. S.; Assaranurak, I.; Brown, P. J.

    2014-01-01

    Sorghum varieties suitable for grain production at temperate latitudes show dwarfism and photoperiod insensitivity, both of which are controlled by a small number of loci with large effects. We studied the genetic control of plant height and flowering time in five sorghum families (A–E), each derived from a cross between a tropical line and a partially isogenic line carrying introgressions derived from a common, temperate-adapted donor. A total of 724 F2:3 lines were phenotyped in temperate and tropical environments for plant height and flowering time and scored at 9139 SNPs using genotyping-by-sequencing. Biparental mapping was compared with multiparental mapping in different subsets of families (AB, ABC, ABCD, and ABCDE) using both a GWAS approach, which fit each QTL as a single effect across all families, and using a joint linkage approach, which fit QTL effects as nested within families. GWAS using all families (ABCDE) performed best at the cloned Dw3 locus, whereas joint linkage using all families performed best at the cloned Ma1 locus. Both multiparental approaches yielded apparently synthetic associations due to genetic heterogeneity and were highly dependent on the subset of families used. Comparison of all mapping approaches suggests that a GA2-oxidase underlies Dw1, and that a mir172a gene underlies a Dw1-linked flowering time QTL. PMID:25237111

  20. Multiparental mapping of plant height and flowering time QTL in partially isogenic sorghum families.

    PubMed

    Higgins, R H; Thurber, C S; Assaranurak, I; Brown, P J

    2014-09-01

    Sorghum varieties suitable for grain production at temperate latitudes show dwarfism and photoperiod insensitivity, both of which are controlled by a small number of loci with large effects. We studied the genetic control of plant height and flowering time in five sorghum families (A-E), each derived from a cross between a tropical line and a partially isogenic line carrying introgressions derived from a common, temperate-adapted donor. A total of 724 F2:3 lines were phenotyped in temperate and tropical environments for plant height and flowering time and scored at 9139 SNPs using genotyping-by-sequencing. Biparental mapping was compared with multiparental mapping in different subsets of families (AB, ABC, ABCD, and ABCDE) using both a GWAS approach, which fit each QTL as a single effect across all families, and using a joint linkage approach, which fit QTL effects as nested within families. GWAS using all families (ABCDE) performed best at the cloned Dw3 locus, whereas joint linkage using all families performed best at the cloned Ma1 locus. Both multiparental approaches yielded apparently synthetic associations due to genetic heterogeneity and were highly dependent on the subset of families used. Comparison of all mapping approaches suggests that a GA2-oxidase underlies Dw1, and that a mir172a gene underlies a Dw1-linked flowering time QTL. PMID:25237111

  1. Multiparental mapping of plant height and flowering time QTL in partially isogenic sorghum families.

    PubMed

    Higgins, R H; Thurber, C S; Assaranurak, I; Brown, P J

    2014-09-18

    Sorghum varieties suitable for grain production at temperate latitudes show dwarfism and photoperiod insensitivity, both of which are controlled by a small number of loci with large effects. We studied the genetic control of plant height and flowering time in five sorghum families (A-E), each derived from a cross between a tropical line and a partially isogenic line carrying introgressions derived from a common, temperate-adapted donor. A total of 724 F2:3 lines were phenotyped in temperate and tropical environments for plant height and flowering time and scored at 9139 SNPs using genotyping-by-sequencing. Biparental mapping was compared with multiparental mapping in different subsets of families (AB, ABC, ABCD, and ABCDE) using both a GWAS approach, which fit each QTL as a single effect across all families, and using a joint linkage approach, which fit QTL effects as nested within families. GWAS using all families (ABCDE) performed best at the cloned Dw3 locus, whereas joint linkage using all families performed best at the cloned Ma1 locus. Both multiparental approaches yielded apparently synthetic associations due to genetic heterogeneity and were highly dependent on the subset of families used. Comparison of all mapping approaches suggests that a GA2-oxidase underlies Dw1, and that a mir172a gene underlies a Dw1-linked flowering time QTL.

  2. Ultrashort coherence times in partially polarized stationary optical beams measured by two-photon absorption.

    PubMed

    Shevchenko, Andriy; Roussey, Matthieu; Friberg, Ari T; Setälä, Tero

    2015-11-30

    We measure the recently introduced electromagnetic temporal degree of coherence of a stationary, partially polarized, classical optical beam. Instead of recording the visibility of intensity fringes, the spectrum, or the polarization characteristics, we introduce a novel technique based on two-photon absorption. Using a Michelson interferometer equipped with polarizers and a specific GaAs photocount tube, we obtain the two fundamental quantities pertaining to the fluctuations of light: the degree of coherence and the degree of polarization. We also show that the electromagnetic intensity-correlation measurements with two-photon absorption require that the polarization dynamics, i.e., the time evolution of the instantaneous polarization state, is properly taken into account. We apply the technique to unpolarized and polarized sources of amplified spontaneous emission (Gaussian statistics) and to a superposition of two independent, narrow-band laser beams of different mid frequencies (non-Gaussian statistics). For these two sources femtosecond-range coherence times are found that are in good agreement with the traditional spectral measurements. Although previously employed for laser pulses, two-photon absorption provides a new physical principle to study electromagnetic coherence phenomena in classical and quantum continuous-wave light at extremely short time scales.

  3. Thermodynamically modulated partially double-stranded linear DNA probe design for homogeneous real-time PCR.

    PubMed

    Huang, Shihai; Salituro, John; Tang, Ning; Luk, Ka-Cheung; Hackett, John; Swanson, Priscilla; Cloherty, Gavin; Mak, Wai-Bing; Robinson, John; Abravaya, Klara

    2007-01-01

    Real-time PCR assays have recently been developed for diagnostic and research purposes. Signal generation in real-time PCR is achieved with probe designs that usually depend on exonuclease activity of DNA polymerase (e.g. TaqMan probe) or oligonucleotide hybridization (e.g. molecular beacon). Probe design often needs to be specifically tailored either to tolerate or to differentiate between sequence variations. The conventional probe technologies offer limited flexibility to meet these diverse requirements. Here, we introduce a novel partially double-stranded linear DNA probe design. It consists of a hybridization probe 5'-labeled with a fluorophore and a shorter quencher oligo of complementary sequence 3'-labeled with a quencher. Fluorescent signal is generated when the hybridization probe preferentially binds to amplified targets during PCR. This novel class of probe can be thermodynamically modulated by adjusting (i) the length of hybridization probe, (ii) the length of quencher oligo, (iii) the molar ratio between the two strands and (iv) signal detection temperature. As a result, pre-amplification signal, signal gain and the extent of mismatch discrimination can be reliably controlled and optimized. The applicability of this design strategy was demonstrated in the Abbott RealTime HIV-1 assay.

  4. Ultrashort coherence times in partially polarized stationary optical beams measured by two-photon absorption.

    PubMed

    Shevchenko, Andriy; Roussey, Matthieu; Friberg, Ari T; Setälä, Tero

    2015-11-30

    We measure the recently introduced electromagnetic temporal degree of coherence of a stationary, partially polarized, classical optical beam. Instead of recording the visibility of intensity fringes, the spectrum, or the polarization characteristics, we introduce a novel technique based on two-photon absorption. Using a Michelson interferometer equipped with polarizers and a specific GaAs photocount tube, we obtain the two fundamental quantities pertaining to the fluctuations of light: the degree of coherence and the degree of polarization. We also show that the electromagnetic intensity-correlation measurements with two-photon absorption require that the polarization dynamics, i.e., the time evolution of the instantaneous polarization state, is properly taken into account. We apply the technique to unpolarized and polarized sources of amplified spontaneous emission (Gaussian statistics) and to a superposition of two independent, narrow-band laser beams of different mid frequencies (non-Gaussian statistics). For these two sources femtosecond-range coherence times are found that are in good agreement with the traditional spectral measurements. Although previously employed for laser pulses, two-photon absorption provides a new physical principle to study electromagnetic coherence phenomena in classical and quantum continuous-wave light at extremely short time scales. PMID:26698754

  5. Dissecting the Space-Time Structure of Tree-Ring Datasets Using the Partial Triadic Analysis

    PubMed Central

    Rossi, Jean-Pierre; Nardin, Maxime; Godefroid, Martin; Ruiz-Diaz, Manuela; Sergent, Anne-Sophie; Martinez-Meier, Alejandro; Pâques, Luc; Rozenberg, Philippe

    2014-01-01

    Tree-ring datasets are used in a variety of circumstances, including archeology, climatology, forest ecology, and wood technology. These data are based on microdensity profiles and consist of a set of tree-ring descriptors, such as ring width or early/latewood density, measured for a set of individual trees. Because successive rings correspond to successive years, the resulting dataset is a ring variables × trees × time datacube. Multivariate statistical analyses, such as principal component analysis, have been widely used for extracting worthwhile information from ring datasets, but they typically address two-way matrices, such as ring variables × trees or ring variables × time. Here, we explore the potential of the partial triadic analysis (PTA), a multivariate method dedicated to the analysis of three-way datasets, to apprehend the space-time structure of tree-ring datasets. We analyzed a set of 11 tree-ring descriptors measured in 149 georeferenced individuals of European larch (Larix decidua Miller) during the period of 1967–2007. The processing of densitometry profiles led to a set of ring descriptors for each tree and for each year from 1967–2007. The resulting three-way data table was subjected to two distinct analyses in order to explore i) the temporal evolution of spatial structures and ii) the spatial structure of temporal dynamics. We report the presence of a spatial structure common to the different years, highlighting the inter-individual variability of the ring descriptors at the stand scale. We found a temporal trajectory common to the trees that could be separated into a high and low frequency signal, corresponding to inter-annual variations possibly related to defoliation events and a long-term trend possibly related to climate change. We conclude that PTA is a powerful tool to unravel and hierarchize the different sources of variation within tree-ring datasets. PMID:25247299

  6. Real-time characterization of partially observed epidemics using surrogate models.

    SciTech Connect

    Safta, Cosmin; Ray, Jaideep; Lefantzi, Sophia; Crary, David; Sargsyan, Khachik; Cheng, Karen

    2011-09-01

    We present a statistical method, predicated on the use of surrogate models, for the 'real-time' characterization of partially observed epidemics. Observations consist of counts of symptomatic patients, diagnosed with the disease, that may be available in the early epoch of an ongoing outbreak. Characterization, in this context, refers to estimation of epidemiological parameters that can be used to provide short-term forecasts of the ongoing epidemic, as well as to provide gross information on the dynamics of the etiologic agent in the affected population e.g., the time-dependent infection rate. The characterization problem is formulated as a Bayesian inverse problem, and epidemiological parameters are estimated as distributions using a Markov chain Monte Carlo (MCMC) method, thus quantifying the uncertainty in the estimates. In some cases, the inverse problem can be computationally expensive, primarily due to the epidemic simulator used inside the inversion algorithm. We present a method, based on replacing the epidemiological model with computationally inexpensive surrogates, that can reduce the computational time to minutes, without a significant loss of accuracy. The surrogates are created by projecting the output of an epidemiological model on a set of polynomial chaos bases; thereafter, computations involving the surrogate model reduce to evaluations of a polynomial. We find that the epidemic characterizations obtained with the surrogate models is very close to that obtained with the original model. We also find that the number of projections required to construct a surrogate model is O(10)-O(10{sup 2}) less than the number of samples required by the MCMC to construct a stationary posterior distribution; thus, depending upon the epidemiological models in question, it may be possible to omit the offline creation and caching of surrogate models, prior to their use in an inverse problem. The technique is demonstrated on synthetic data as well as observations from

  7. Dissecting the space-time structure of tree-ring datasets using the partial triadic analysis.

    PubMed

    Rossi, Jean-Pierre; Nardin, Maxime; Godefroid, Martin; Ruiz-Diaz, Manuela; Sergent, Anne-Sophie; Martinez-Meier, Alejandro; Pâques, Luc; Rozenberg, Philippe

    2014-01-01

    Tree-ring datasets are used in a variety of circumstances, including archeology, climatology, forest ecology, and wood technology. These data are based on microdensity profiles and consist of a set of tree-ring descriptors, such as ring width or early/latewood density, measured for a set of individual trees. Because successive rings correspond to successive years, the resulting dataset is a ring variables × trees × time datacube. Multivariate statistical analyses, such as principal component analysis, have been widely used for extracting worthwhile information from ring datasets, but they typically address two-way matrices, such as ring variables × trees or ring variables × time. Here, we explore the potential of the partial triadic analysis (PTA), a multivariate method dedicated to the analysis of three-way datasets, to apprehend the space-time structure of tree-ring datasets. We analyzed a set of 11 tree-ring descriptors measured in 149 georeferenced individuals of European larch (Larix decidua Miller) during the period of 1967-2007. The processing of densitometry profiles led to a set of ring descriptors for each tree and for each year from 1967-2007. The resulting three-way data table was subjected to two distinct analyses in order to explore i) the temporal evolution of spatial structures and ii) the spatial structure of temporal dynamics. We report the presence of a spatial structure common to the different years, highlighting the inter-individual variability of the ring descriptors at the stand scale. We found a temporal trajectory common to the trees that could be separated into a high and low frequency signal, corresponding to inter-annual variations possibly related to defoliation events and a long-term trend possibly related to climate change. We conclude that PTA is a powerful tool to unravel and hierarchize the different sources of variation within tree-ring datasets.

  8. Time-dependent mechanical behavior of partially stabilized zirconia for diesel engine applications: Final report

    SciTech Connect

    Ferber, M.K.; Hine, T.

    1988-07-01

    Recently there has been considerable interest in utilizing ceramic materials in diesel engine applications. And as a result of this interest, the fatigue behavior of several commercially-available MgO partially stabilized zirconias (Mg-PSZ) was studied by measuring the strength (S/sub f/ as a function of time (t), temperature (T), and applied stress level (sigma). The two Mg-PSZ types included TS PSZ (thermal shock grade) and MS PSZ (maximum strength grade/1983 vintage). Both 1983 and 1984 vintages of the TS PSZ (designated TS(83) and TS(84)) were examined. The strength was determined using an interrupted fatigue (I.F.) test in which flexure samples were exposed at temperatures between 500 and 1000/degree/C for times up to 1000 h. During testing, the applied stress was maintained at a percentage of the short-term S/sub f/ value measured at the same T. Specific stress levels included 0, 60, 70, and 80%. The following techniques were used to characterize both the as-received and tested I.F. specimens: (1) SEM, (2) TEM, (3) optical microscopy, (4) x-ray diffraction, (5) micro-Raman spectroscopy, and (6) dilatometry. SEM allowed for routine examination of the microstructures and fracture surfaces. Changes in the primary phase assemblage resulting from the high-temperature exposure were monitored using x-ray diffraction, Raman spectroscopy, and standard optical phase analysis. The hysteresis characteristics which were determined from dilational measurements provided insights into the nature of the tetragonal (t) to monoclinic (m) transformation and thus the stability of the (t) precipitates. Finally, TEM was used to study the influence of stress, time, and temperature upon the microstructure of the I.F. samples. 26 refs., 23 figs., 4 tabs.

  9. The activated coagulation time of whole blood as a routine pre-operative sceening test.

    PubMed

    Hattersley, P G

    1971-05-01

    Patients with disorders of hemostasis who undergo surgical procedures are in danger of hemorrhage. While the careful medical history remains the most sensitive test of a bleeding tendency, some such patients can give no suggestive history. In three patients with coagulopathy-one with mild classical hemophilia, one with Christmas disease, and one with warfarin toxicity-the abnormality was missed by routine preoperative history but promptly detected by the routine preoperative use of the activated coagulation time (act). Either this test or the activated partial thromboplastin time should be included in the routine preoperative work-up, along with appropriate additional tests of the hemostatic mechanism.

  10. Time Resolved 2D X-Ray Densitometry of a Ventilated Partial Cavity Closure

    NASA Astrophysics Data System (ADS)

    Makiharju, Simo; Ceccio, Steven

    2011-11-01

    A time resolved x-ray densitometry system was developed to measure the spatial distribution of void fraction for nominally two-dimensional flows. The system can image a region of (15 cm)2 at a frame rate of up to 4000 fps. The source was a rotating anode type normally used for cineradiography and angiography. Supplied by a 65 kW high frequency generator with a high speed starter, it could be operated at up to 433 mA at 150 kV. The imager subsystem comprised of a high speed camera coupled with a high resolution image intensifier. The range of measured void fraction can be changed to span a desired range yielding an uncertainty on the order of 1% of the measurement range. The system is used to examine the void fraction field in the closure region of a ventilated partial cavity behind a backward facing step. The cavity has Reynolds number of O(105) based on the cavity length, and a non-dimensional gas flux of Q* = 0.0048. The bubbly flow created in the cavity wake is examined using the x-ray densitometry system, duel fiber optical probes, and high speed cinematography. The local void fraction and bubble size distributions in the cavity wake are determined, and the measurements methods are compared. The research was sponsored by ONR under grant N00014-08-1-0215, program manager Dr. L. Patrick Purtell.

  11. Actor-critic-based optimal tracking for partially unknown nonlinear discrete-time systems.

    PubMed

    Kiumarsi, Bahare; Lewis, Frank L

    2015-01-01

    This paper presents a partially model-free adaptive optimal control solution to the deterministic nonlinear discrete-time (DT) tracking control problem in the presence of input constraints. The tracking error dynamics and reference trajectory dynamics are first combined to form an augmented system. Then, a new discounted performance function based on the augmented system is presented for the optimal nonlinear tracking problem. In contrast to the standard solution, which finds the feedforward and feedback terms of the control input separately, the minimization of the proposed discounted performance function gives both feedback and feedforward parts of the control input simultaneously. This enables us to encode the input constraints into the optimization problem using a nonquadratic performance function. The DT tracking Bellman equation and tracking Hamilton-Jacobi-Bellman (HJB) are derived. An actor-critic-based reinforcement learning algorithm is used to learn the solution to the tracking HJB equation online without requiring knowledge of the system drift dynamics. That is, two neural networks (NNs), namely, actor NN and critic NN, are tuned online and simultaneously to generate the optimal bounded control policy. A simulation example is given to show the effectiveness of the proposed method. PMID:25312944

  12. Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase.

    PubMed

    Kage, Hirokazu; Riva, Elena; Parascandolo, James S; Kreutzer, Martin F; Tosin, Manuela; Nett, Markus

    2015-12-21

    Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin. PMID:26507693

  13. A Comparison of Momentary Time Sampling and Partial-Interval Recording for Assessment of Effects of Social Skills Training

    ERIC Educational Resources Information Center

    Radley, Keith C.; O'Handley, Roderick D.; Labrot, Zachary C.

    2015-01-01

    Assessment in social skills training often utilizes procedures such as partial-interval recording (PIR) and momentary time sampling (MTS) to estimate changes in duration in social engagements due to intervention. Although previous research suggests PIR to be more inaccurate than MTS in estimating levels of behavior, treatment analysis decisions…

  14. In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction in Factor IX-Deficient Dogs

    NASA Astrophysics Data System (ADS)

    Kay, Mark A.; Rothenberg, Steven; Landen, Charles N.; Bellinger, Dwight A.; Leland, Frances; Toman, Carol; Finegold, Milton; Thompson, Arthur R.; Read, M. S.; Brinkhous, Kenneth M.; Woo, Savio L. C.

    1993-10-01

    The liver represents a model organ for gene therapy. A method has been developed for hepatic gene transfer in vivo by the direct infusion of recombinant retroviral vectors into the portal vasculature, which results in the persistent expression of exogenous genes. To determine if these technologies are applicable for the treatment of hemophilia B patients, preclinical efficacy studies were done in a hemophilia B dog model. When the canine factor IX complementary DNA was transduced directly into the hepatocytes of affected dogs in vivo, the animals constitutively expressed low levels of canine factor IX for more than 5 months. Persistent expression of the clotting. factor resulted in reductions of whole blood clotting and partial thromboplastin times of the treated animals. Thus, long-term treatment of hemophilia B patients may be feasible by direct hepatic gene therapy in vivo.

  15. Isostable reduction with applications to time-dependent partial differential equations

    NASA Astrophysics Data System (ADS)

    Wilson, Dan; Moehlis, Jeff

    2016-07-01

    Isostables and isostable reduction, analogous to isochrons and phase reduction for oscillatory systems, are useful in the study of nonlinear equations which asymptotically approach a stationary solution. In this work, we present a general method for isostable reduction of partial differential equations, with the potential power to reduce the dimensionality of a nonlinear system from infinity to 1. We illustrate the utility of this reduction by applying it to two different models with biological relevance. In the first example, isostable reduction of the Fokker-Planck equation provides the necessary framework to design a simple control strategy to desynchronize a population of pathologically synchronized oscillatory neurons, as might be relevant to Parkinson's disease. Another example analyzes a nonlinear reaction-diffusion equation with relevance to action potential propagation in a cardiac system.

  16. Isostable reduction with applications to time-dependent partial differential equations.

    PubMed

    Wilson, Dan; Moehlis, Jeff

    2016-07-01

    Isostables and isostable reduction, analogous to isochrons and phase reduction for oscillatory systems, are useful in the study of nonlinear equations which asymptotically approach a stationary solution. In this work, we present a general method for isostable reduction of partial differential equations, with the potential power to reduce the dimensionality of a nonlinear system from infinity to 1. We illustrate the utility of this reduction by applying it to two different models with biological relevance. In the first example, isostable reduction of the Fokker-Planck equation provides the necessary framework to design a simple control strategy to desynchronize a population of pathologically synchronized oscillatory neurons, as might be relevant to Parkinson's disease. Another example analyzes a nonlinear reaction-diffusion equation with relevance to action potential propagation in a cardiac system. PMID:27575127

  17. Fast Time and Space Parallel Algorithms for Solution of Parabolic Partial Differential Equations

    NASA Technical Reports Server (NTRS)

    Fijany, Amir

    1993-01-01

    In this paper, fast time- and Space -Parallel agorithms for solution of linear parabolic PDEs are developed. It is shown that the seemingly strictly serial iterations of the time-stepping procedure for solution of the problem can be completed decoupled.

  18. The large discretization step method for time-dependent partial differential equations

    NASA Technical Reports Server (NTRS)

    Haras, Zigo; Taasan, Shlomo

    1995-01-01

    A new method for the acceleration of linear and nonlinear time dependent calculations is presented. It is based on the Large Discretization Step (LDS) approximation, defined in this work, which employs an extended system of low accuracy schemes to approximate a high accuracy discrete approximation to a time dependent differential operator. Error bounds on such approximations are derived. These approximations are efficiently implemented in the LDS methods for linear and nonlinear hyperbolic equations, presented here. In these algorithms the high and low accuracy schemes are interpreted as the same discretization of a time dependent operator on fine and coarse grids, respectively. Thus, a system of correction terms and corresponding equations are derived and solved on the coarse grid to yield the fine grid accuracy. These terms are initialized by visiting the fine grid once in many coarse grid time steps. The resulting methods are very general, simple to implement and may be used to accelerate many existing time marching schemes.

  19. Bayesian classification of partially observed outbreaks using time-series data.

    SciTech Connect

    Safta, Cosmin; Ray, Jaideep; Crary, David; Cheng, Karen

    2010-05-01

    Results show that a time-series based classification may be possible. For the test cases considered, the correct model can be selected and the number of index case can be captured within {+-} {sigma} with 5-10 days of data. The low signal-to-noise ratio makes the classification difficult for small epidemics. The problem statement is: (1) Create Bayesian techniques to classify and characterize epidemics from a time-series of ICD-9 codes (will call this time-series a 'morbidity stream'); and (2) It is assumed the morbidity stream has already set off an alarm (through a Kalman filter anomaly detector) Starting with a set of putative diseases: Identify which disease or set of diseases 'fit the data best' and, Infer associated information about it, i.e. number of index cases, start time of the epidemic, spread rate, etc.

  20. The adaptive CCCG({eta}) method for efficient solution of time dependent partial differential equations

    SciTech Connect

    Campos, F.F.; Birkett, N.R.C.

    1996-12-31

    The Controlled Cholesky factorisation has been shown to be a robust preconditioner for the Conjugate Gradient method. In this scheme the amount of fill-in is defined in terms of a parameter {eta}, the number of extra elements allowed per column. It is demonstrated how an optimum value of {eta} can be automatically determined when solving time dependent p.d.e.`s using an implicit time step method. A comparison between CCCG({eta}) and the standard ICCG solving parabolic problems on general grids shows CCCG({eta}) to be an efficient general purpose solver.

  1. Acceleration of yoghurt fermentation time by yeast extract and partial characterisation of the active components.

    PubMed

    Smith, Esti-Andrine; Myburgh, Jacobus; Osthoff, Gernot; de Wit, Maryna

    2014-11-01

    Water soluble autolysate of yeast, usually utilised for microbial growth support, was used as additive in yoghurt fermentation. The yeast extract (YE) resulted in a decrease of fermentation time by 21% to reach a pH of 4·6. However, the YE resulted in unacceptable flavour and taste. By size exclusion chromatography, a fraction of the YE was obtained that could account for the observed 21% decrease in fermentation time. The fraction contained molecules of low molecular weight, consisting of minerals, free amino acids and peptides. The acceleration of the yoghurt fermentation was ascribed to the short peptides in the fraction. It is proposed that the application of this extract in industrial yoghurt manufacture would result in savings for both the industry and the consumer.

  2. Neural network approach to continuous-time direct adaptive optimal control for partially unknown nonlinear systems.

    PubMed

    Vrabie, Draguna; Lewis, Frank

    2009-04-01

    In this paper we present in a continuous-time framework an online approach to direct adaptive optimal control with infinite horizon cost for nonlinear systems. The algorithm converges online to the optimal control solution without knowledge of the internal system dynamics. Closed-loop dynamic stability is guaranteed throughout. The algorithm is based on a reinforcement learning scheme, namely Policy Iterations, and makes use of neural networks, in an Actor/Critic structure, to parametrically represent the control policy and the performance of the control system. The two neural networks are trained to express the optimal controller and optimal cost function which describes the infinite horizon control performance. Convergence of the algorithm is proven under the realistic assumption that the two neural networks do not provide perfect representations for the nonlinear control and cost functions. The result is a hybrid control structure which involves a continuous-time controller and a supervisory adaptation structure which operates based on data sampled from the plant and from the continuous-time performance dynamics. Such control structure is unlike any standard form of controllers previously seen in the literature. Simulation results, obtained considering two second-order nonlinear systems, are provided.

  3. Neural network approach to continuous-time direct adaptive optimal control for partially unknown nonlinear systems.

    PubMed

    Vrabie, Draguna; Lewis, Frank

    2009-04-01

    In this paper we present in a continuous-time framework an online approach to direct adaptive optimal control with infinite horizon cost for nonlinear systems. The algorithm converges online to the optimal control solution without knowledge of the internal system dynamics. Closed-loop dynamic stability is guaranteed throughout. The algorithm is based on a reinforcement learning scheme, namely Policy Iterations, and makes use of neural networks, in an Actor/Critic structure, to parametrically represent the control policy and the performance of the control system. The two neural networks are trained to express the optimal controller and optimal cost function which describes the infinite horizon control performance. Convergence of the algorithm is proven under the realistic assumption that the two neural networks do not provide perfect representations for the nonlinear control and cost functions. The result is a hybrid control structure which involves a continuous-time controller and a supervisory adaptation structure which operates based on data sampled from the plant and from the continuous-time performance dynamics. Such control structure is unlike any standard form of controllers previously seen in the literature. Simulation results, obtained considering two second-order nonlinear systems, are provided. PMID:19362449

  4. Expectation-maximization algorithms for learning a finite mixture of univariate survival time distributions from partially specified class values

    SciTech Connect

    Lee, Youngrok

    2013-05-15

    Heterogeneity exists on a data set when samples from di erent classes are merged into the data set. Finite mixture models can be used to represent a survival time distribution on heterogeneous patient group by the proportions of each class and by the survival time distribution within each class as well. The heterogeneous data set cannot be explicitly decomposed to homogeneous subgroups unless all the samples are precisely labeled by their origin classes; such impossibility of decomposition is a barrier to overcome for estimating nite mixture models. The expectation-maximization (EM) algorithm has been used to obtain maximum likelihood estimates of nite mixture models by soft-decomposition of heterogeneous samples without labels for a subset or the entire set of data. In medical surveillance databases we can find partially labeled data, that is, while not completely unlabeled there is only imprecise information about class values. In this study we propose new EM algorithms that take advantages of using such partial labels, and thus incorporate more information than traditional EM algorithms. We particularly propose four variants of the EM algorithm named EM-OCML, EM-PCML, EM-HCML and EM-CPCML, each of which assumes a specific mechanism of missing class values. We conducted a simulation study on exponential survival trees with five classes and showed that the advantages of incorporating substantial amount of partially labeled data can be highly signi cant. We also showed model selection based on AIC values fairly works to select the best proposed algorithm on each specific data set. A case study on a real-world data set of gastric cancer provided by Surveillance, Epidemiology and End Results (SEER) program showed a superiority of EM-CPCML to not only the other proposed EM algorithms but also conventional supervised, unsupervised and semi-supervised learning algorithms.

  5. Salt transport and the time-dependent salt balance of a partially stratified estuary

    NASA Astrophysics Data System (ADS)

    Bowen, Melissa M.; Geyer, W. Rockwell

    2003-05-01

    The transport of salt along the channel of an estuary determines the length of the saline intrusion and provides bounds on the transfer of other substances. Observations of salt transport have been hampered by a lack of long time series measurements and complexities of the sampling situation (e.g., local topography and simultaneous variations of tides, freshwater, and winds). Here we estimate salt transport at a relatively uniform section of the Hudson Estuary over a 70-day period during drought conditions. The salt balance of the estuary is also assessed by comparing salt transport at the section with surveys of total salt content in the estuary. Most salt enters the estuary in monthly pulses of estuarine salt transport (i.e., spatial variations of tidally-averaged velocity and salinity) during apogean neap tides when vertical stratification is greatest. Oscillatory salt transport (i.e., the covariance of tidally-varying velocity and salinity) is a more minor player in the salt balance and shows a surprising lack of spring-neap variation. Integrated salt transport at the section is consistent with estimates of total salt content of the estuary; however, the mismatch in magnitude of the variations indicates that the salinity intrusion is not in equilibrium within the spring-neap cycle. In contrast, the salt balance adjusts rapidly to an increase in freshwater flow at the end of the deployment. A scaling argument is derived to illustrate the adjustment of the salinity intrusion to the tides and freshwater flow. The results suggest that time dependence is an intrinsic part of the estuarine salt balance.

  6. Mixed Effects Models for Recurrent Events Data with Partially Observed Time-Varying Covariates: Ecological Momentary Assessment of Smoking

    PubMed Central

    Rathbun, Stephen L.; Shiffman, Saul

    2015-01-01

    Summary Cigarette smoking is a prototypical example of a recurrent event. The pattern of recurrent smoking events may depend on time-varying covariates including mood and environmental variables. Fixed effects and frailty models for recurrent events data assume that smokers have a common association with time-varying covariates. We develop a mixed effects version of a recurrent events model that may be used to describe variation among smokers in how they respond to those covariates, potentially leading to the development of individual-based smoking cessation therapies. Our method extends the modified EM algorithm of Steele (1996) for generalized mixed models to recurrent events data with partially observed time-varying covariates. It is offered as an alternative to the method of Rizopoulos, Verbeke and Lesaffre (2009) who extended Steele’s (1996) algorithm to a joint-model for the recurrent events data and time-varying covariates. Our approach does not require a model for the time-varying covariates, but instead assumes that the time-varying covariates are sampled according to a Poisson point process with known intensity. Our methods are well suited to data collected using Ecological Momentary Assessment (EMA), a method of data collection widely used in the behavioral sciences to collect data on emotional state and recurrent events in the every-day environments of study subjects using electronic devices such as Personal Digital Assistants (PDA) or smart phones. PMID:26410189

  7. Reliable Real-Time Solution of Parametrized Partial Differential Equations: Reduced-Basis Output Bound Methods. Appendix 2

    NASA Technical Reports Server (NTRS)

    Prudhomme, C.; Rovas, D. V.; Veroy, K.; Machiels, L.; Maday, Y.; Patera, A. T.; Turinici, G.; Zang, Thomas A., Jr. (Technical Monitor)

    2002-01-01

    We present a technique for the rapid and reliable prediction of linear-functional outputs of elliptic (and parabolic) partial differential equations with affine parameter dependence. The essential components are (i) (provably) rapidly convergent global reduced basis approximations, Galerkin projection onto a space W(sub N) spanned by solutions of the governing partial differential equation at N selected points in parameter space; (ii) a posteriori error estimation, relaxations of the error-residual equation that provide inexpensive yet sharp and rigorous bounds for the error in the outputs of interest; and (iii) off-line/on-line computational procedures, methods which decouple the generation and projection stages of the approximation process. The operation count for the on-line stage, in which, given a new parameter value, we calculate the output of interest and associated error bound, depends only on N (typically very small) and the parametric complexity of the problem; the method is thus ideally suited for the repeated and rapid evaluations required in the context of parameter estimation, design, optimization, and real-time control.

  8. Efficient estimation of the distribution of time to composite endpoint when some endpoints are only partially observed.

    PubMed

    Daniel, Rhian M; Tsiatis, Anastasios A

    2013-10-01

    Two common features of clinical trials, and other longitudinal studies, are (1) a primary interest in composite endpoints, and (2) the problem of subjects withdrawing prematurely from the study. In some settings, withdrawal may only affect observation of some components of the composite endpoint, for example when another component is death, information on which may be available from a national registry. In this paper, we use the theory of augmented inverse probability weighted estimating equations to show how such partial information on the composite endpoint for subjects who withdraw from the study can be incorporated in a principled way into the estimation of the distribution of time to composite endpoint, typically leading to increased efficiency without relying on additional assumptions above those that would be made by standard approaches. We describe our proposed approach theoretically, and demonstrate its properties in a simulation study. PMID:23722304

  9. Efficient estimation of the distribution of time to composite endpoint when some endpoints are only partially observed

    PubMed Central

    Daniel, Rhian M.; Tsiatis, Anastasios A.

    2014-01-01

    Two common features of clinical trials, and other longitudinal studies, are (1) a primary interest in composite endpoints, and (2) the problem of subjects withdrawing prematurely from the study. In some settings, withdrawal may only affect observation of some components of the composite endpoint, for example when another component is death, information on which may be available from a national registry. In this paper, we use the theory of augmented inverse probability weighted estimating equations to show how such partial information on the composite endpoint for subjects who withdraw from the study can be incorporated in a principled way into the estimation of the distribution of time to composite endpoint, typically leading to increased efficiency without relying on additional assumptions above those that would be made by standard approaches. We describe our proposed approach theoretically, and demonstrate its properties in a simulation study. PMID:23722304

  10. Measurements of time-dependent CP asymmetries in B→D*∓π± decays using a partial reconstruction technique

    DOE PAGES

    Bahinipati, S.; Trabelsi, K.; Kinoshita, K.; Arinstein, K.; Aulchenko, V.; Aushev, T.; Bakich, A. M.; Balagura, V.; Barberio, E.; Belous, K.; et al

    2011-07-05

    We report results on time-dependent CP asymmetries in B→D*∓π± decays based on a data sample containing 657×10⁶ BB¯ pairs collected with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider at the Υ(4S) resonance. We use a partial reconstruction technique, wherein signal B→D*∓π± events are identified using information only from the fast pion from the B decay and the slow pion from the subsequent decay of the D*∓, where the former (latter) corresponds to D*⁺(D*⁻) final states. We obtain CP violation parameters S⁺=+0.061±0.018 (stat)±0.012 (syst) and S⁻=+0.031±0.019 (stat)±0.015 (syst).

  11. Mismatch between fishway operation and timing of fish movements: a risk for cascading effects in partial migration systems.

    PubMed

    van Leeuwen, Casper H A; Museth, Jon; Sandlund, Odd T; Qvenild, Tore; Vøllestad, L Asbjørn

    2016-04-01

    Habitat fragmentation is a growing problem worldwide. Particularly in river systems, numerous dams and weirs hamper the movement of a wide variety of species. With the aim to preserve connectivity for fish, many barriers in river systems are equipped with fishways (also called fish passages or fish ladders). However, few fishways provide full connectivity. Here we hypothesized that restricted seasonal opening times of fishways can importantly reduce their effectiveness by interfering with the timing of fish migration, for both spring- and autumn-spawning species. We empirically tested our hypothesis, and discuss the possible eco-evolutionary consequences of affected migration timing. We analyzed movements of two salmonid fishes, spring-spawning European grayling (Thymallus thymallus) and autumn-spawning brown trout (Salmo trutta), in Norway's two largest river systems. We compared their timing of upstream passage through four fishways collected over 28 years with the timing of fish movements in unfragmented river sections as monitored by radiotelemetry. Confirming our hypothesis, late opening of fishways delayed the migration of European grayling in spring, and early closure of fishways blocked migration for brown trout on their way to spawning locations during late autumn. We show in a theoretical framework how restricted opening times of fishways can induce shifts from migratory to resident behavior in potamodromous partial migration systems, and propose that this can induce density-dependent effects among fish accumulating in lower regions of rivers. Hence, fragmentation may not only directly affect the migratory individuals in the population, but may also have effects that cascade downstream and alter circumstances for resident fish. Fishway functionality is inadequate if there is a mismatch between natural fish movements and fishway opening times in the same river system, with ecological and possibly evolutionary consequences for fish populations. PMID

  12. Effect of storage time and framework design on the accuracy of maxillary cobalt-chromium cast removable partial dentures

    PubMed Central

    Viswambaran, M.; Sundaram, R. K.

    2015-01-01

    Statement of Problem: Inaccuracies in the fit of palatal major connectors may be related to distortion of the wax pattern due to prolonged storage time and faulty major connector design. Purpose: This in vitro study was carried out to find out the effect of storage time and major connector design on the accuracy of cobalt-chromium cast removable partial dentures (RPDs). Materials and Methods: A brass metal die with a Kennedy Class III, modification 1, the partially edentulous arch was used as a master die. Thirty-six refractory casts were fabricated from the master die. The refractory casts were divided into three groups (Group I: Anterior-posterior palatal bar, Group II: Palatal strap and Group III: Palatal plate) based on the design of maxillary major connector and subdivided into four groups (sub Group A: 01 h, sub Group B: 03 h, Sub Group C: 06 h, and sub Group D: 24 h) based on the storage time. For each group, 12 frameworks were fabricated. The influence of wax pattern storage time and the accuracy of the fit palatal major connector designs on the master die were compared. Casting defects (nodules/incompleteness) of the frameworks were also evaluated before finishing and polishing. Repeated measures analysis of variance was used to analyze the data. Results: The gap discrepancy was least in sub Group A (01 h) followed by sub Group B (03 h) and C (06 h) and most in sub Group D (24 h). Statistically significant differences (P < 0.05 in all locations L1–L5) in the fit of the framework were related to the design of the major connector. The gap discrepancy was least in Group I (anterior-posterior palatal bar) followed by Group II (palatal strap) and most in Group II (palatal plate). Conclusions: It is recommended that the wax patterns for RPD to be invested immediately on completion of the wax procedure. The selection of a major connector design is crucial for an accurate fit of RPD. PMID:26681850

  13. Measurement of the Time-Dependent CP Asymmetry of Partially Reconstructed B0 to D*+D*- Decays

    SciTech Connect

    Lees, J. P.

    2012-08-13

    We present a new measurement of the time-dependent CP asymmetry of B{sup 0} {yields}D*{sup +}D*{sup -} decays using (471 {+-} 5) million B{bar B} pairs collected with the BABAR detector at the PEP-II B Factory at the SLAC National Accelerator Laboratory. Using the technique of partial reconstruction, we measure the time-dependent CP asymmetry parameters S = -0.34 {+-} 0.12 {+-} 0.05 and C = +0:15 {+-} 0.09 {+-} 0.04. Using the value for the CP-odd fraction R{perpendicular} = 0.158 {+-} 0.028 {+-} 0.006, previously measured by BABAR with fully reconstructed B{sup 0} {yields} D{sup *+}D{sup *-} events, we extract the CP-even components S{sub +} = -0.49 {+-} 0.18 {+-} 0.07 {+-} 0.04 and C{sub +} = +0.15 {+-} 0.09 {+-} 0.04. In each case, the first uncertainty is statistical and the second is systematic; the third uncertainty on S{sub +} is the contribution from the uncertainty on R{perpendicular}. The measured value of the CP-even component S{sub +} is consistent with the value of sin 2{beta} measured in b {yields} (c{bar c})s transitions, and with the Standard Model expectation of small penguin contributions.

  14. Formulation of singular theories in a partial Hamiltonian formalism using a new bracket and multi-time dynamics

    NASA Astrophysics Data System (ADS)

    Duplij, Steven

    2015-09-01

    A formulation of singular classical theories (determined by degenerate Lagrangians) without constraints is presented. A partial Hamiltonian formalism in the phase space having an initially arbitrary number of momenta (which can be smaller than the number of velocities) is proposed. The equations of motion become first-order differential equations, and they coincide with those of multi-time dynamics, if a certain condition is imposed. In a singular theory, this condition is fulfilled in the case of the coincidence of the number of generalized momenta with the rank of the Hessian matrix. The noncanonical generalized velocities satisfy a system of linear algebraic equations, which allows an appropriate classification of singular theories (gauge and nongauge). A new antisymmetric bracket (similar to the Poisson bracket) is introduced, which describes the time evolution of physical quantities in a singular theory. The origin of constraints is shown to be a consequence of the (unneeded in our formulation) extension of the phase space, when the new bracket transforms into the Dirac bracket. Quantization is briefly discussed.

  15. Partial purification and characterization of contact activation cofactor.

    PubMed Central

    Schiffman, S; Lee, P

    1975-01-01

    The contact phase of intrinsic clotting involves Factor XI, Factor XII, Fletcher factor, and a fourth activity that we call contact activation cofactor (CAC). All four of these activities are reduced or absent in Dicalite-adsorbed plasma. A modified activated partial thromboplastin time assay for CAC has been defined by using a substrate of Dicalite-adsorbed plasma combined with partially purified sources of Factors XI and XII, and Fletcher factor. The following properties of CAC in plasma have been determined by using the assay: it is stable up to 60 min at 56 degrees C; gradually loses activity at 80 degrees C; is stable between pH 6 and 9; is precipitated by ammonium sulfate between 40% and 50% saturation; is slightly adsorbed by A1(OH)3; and is eluted from DEAE-cellulose after the major protein peaks. A purification procedure has been devised that separates CAC from other known clotting factors. Isolated CAC was less stable than CAC in plasma, but in the presence of dilute human serum albumin it retained full activity for 80 min at 56 degrees C. On gel filtration CAC had an apparent mol wt of 220,000 daltons. These properties are consistent with those described for Fitzgerald factor, which further supports the conclusion that CAC and Fitzgerald factor represent the same activity. Isolated CAC promoted the generation of activated Factor XI (XIa) in a mixture containing purified Factor XI, Factor XII, and kaolin. The amount of Factor XIa generated was proportional to the amount of added CAC. No time-consuming reaction between Factor XI or Factor XII and CAC could be demonstrated. PMID:1184736

  16. Shortened blood coagulation times in genetically obese rats and diet-induced obese mice.

    PubMed

    Kaji, Noriyuki; Nagakubo, Dai; Hashida, Shin-Ichi; Takahashi, Saya; Kuratani, Motoi; Hirai, Norihiko; Shirai, Mitsuyuki; Asai, Fumitoshi

    2013-01-01

    The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.

  17. Inter-costal Liver Ablation Under Real Time MR-Thermometry With Partial Activation Of A HIFU Phased Array Transducer

    NASA Astrophysics Data System (ADS)

    Quesson, Bruno; Merle, Mathilde; Köhler, Max; Mougenot, Charles; Roujol, Sebastien; de Senneville, Baudouin Denis; Moonen, Chrit

    2010-03-01

    HIFU ablation of tumours located inside the liver is hampered by the rib cage, which partially obstructs the beam path and may create adverse effects such as skin burns. This study presents a method for selectively deactivating the transducer elements causing undesired temperature increases near the bones. A manual segmentation of the bones visualized on 3D anatomical MR images acquired prior to sonication was performed to identify the beam obstruction. The resulting mask was projected (ray tracing starting from the focal point) on the transducer and elements with more than 50% obstruction of their active surface were deactivated. The effectiveness of the method for HIFU ablations is demonstrated ex vivo and in vivo in the liver of pigs with real-time MR thermometry, using the proton resonant frequency (PRF) method. For both ex vivo and in vivo experiments, the temperature increase near the bones was significantly reduced when the elements located in front of the ribs were deactivated. The temperature evolution at the focal point were similar, indicative of the absence of loss of heating efficacy when the elements were deactivated. This method is simple, rapid and reliable and allows to perform intercostal MRgHIFU ablation of the liver while sparing the ribs.

  18. Real-time visualization of oxygen partial pressures in straight channels of running polymer electrolyte fuel cell with water plugging

    NASA Astrophysics Data System (ADS)

    Nagase, Katsuya; Suga, Takeo; Nagumo, Yuzo; Uchida, Makoto; Inukai, Junji; Nishide, Hiroyuki; Watanabe, Masahiro

    2015-01-01

    Visualization inside polymer electrolyte fuel cells (PEFCs) for elucidating the reaction distributions is expected to improve the performance, durability, and stability. An oxygen-sensitive film of a luminescent porphyrin was used to visualize the oxygen partial pressures in five straight gas-flow channels of a running PEFC with liquid-water blockages formed at the end of the channels. The blockage greatly lowered and unstabilized the cell voltage. The oxygen partial pressure decreased nearly to 0 kPa in the blocked channel. With a water blockage in a channel, the oxygen partial pressures in the adjacent channels were lowered due to an extra demand of oxygen consumption. When the number of the blocked channels increased, the oxygen partial pressure in the unblocked channels became much lowered. When the water blockages disappeared, the oxygen partial pressures quickly returned to the values before plugging. The influence of the cross flows of air through the gas diffusion layers in straight channels was much smaller than that in serpentine flow channels.

  19. 76 FR 68128 - Fresh Garlic From the People's Republic of China: Extension of Time Limit for Partial Preliminary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... Revocation in Part, 75 FR 81565 (December 28, 2010). On July 15, 2011, the Department published a notice in... Antidumping Duty Administrative Review, 76 FR 41795 (July 15, 2011). On October 20, 2011, the Department..., the 2009-2010 Administrative Review, 76 FR 65172 (October 20, 2011) (First Partial Preliminary...

  20. Partial volume correction of brain perfusion estimates using the inherent signal data of time-resolved arterial spin labeling.

    PubMed

    Ahlgren, André; Wirestam, Ronnie; Petersen, Esben Thade; Ståhlberg, Freddy; Knutsson, Linda

    2014-09-01

    Quantitative perfusion MRI based on arterial spin labeling (ASL) is hampered by partial volume effects (PVEs), arising due to voxel signal cross-contamination between different compartments. To address this issue, several partial volume correction (PVC) methods have been presented. Most previous methods rely on segmentation of a high-resolution T1 -weighted morphological image volume that is coregistered to the low-resolution ASL data, making the result sensitive to errors in the segmentation and coregistration. In this work, we present a methodology for partial volume estimation and correction, using only low-resolution ASL data acquired with the QUASAR sequence. The methodology consists of a T1 -based segmentation method, with no spatial priors, and a modified PVC method based on linear regression. The presented approach thus avoids prior assumptions about the spatial distribution of brain compartments, while also avoiding coregistration between different image volumes. Simulations based on a digital phantom as well as in vivo measurements in 10 volunteers were used to assess the performance of the proposed segmentation approach. The simulation results indicated that QUASAR data can be used for robust partial volume estimation, and this was confirmed by the in vivo experiments. The proposed PVC method yielded probable perfusion maps, comparable to a reference method based on segmentation of a high-resolution morphological scan. Corrected gray matter (GM) perfusion was 47% higher than uncorrected values, suggesting a significant amount of PVEs in the data. Whereas the reference method failed to completely eliminate the dependence of perfusion estimates on the volume fraction, the novel approach produced GM perfusion values independent of GM volume fraction. The intra-subject coefficient of variation of corrected perfusion values was lowest for the proposed PVC method. As shown in this work, low-resolution partial volume estimation in connection with ASL perfusion

  1. A flowing liquid test system for assessing the linearity and time-response of rapid fibre optic oxygen partial pressure sensors.

    PubMed

    Chen, R; Hahn, C E W; Farmery, A D

    2012-08-15

    The development of a methodology for testing the time response, linearity and performance characteristics of ultra fast fibre optic oxygen sensors in the liquid phase is presented. Two standard medical paediatric oxygenators are arranged to provide two independent extracorporeal circuits. Flow from either circuit can be diverted over the sensor under test by means of a system of rapid cross-over solenoid valves exposing the sensor to an abrupt change in oxygen partial pressure, P O2. The system is also capable of testing the oxygen sensor responses to changes in temperature, carbon dioxide partial pressure P CO2 and pH in situ. Results are presented for a miniature fibre optic oxygen sensor constructed in-house with a response time ≈ 50 ms and a commercial fibre optic sensor (Ocean Optics Foxy), when tested in flowing saline and stored blood.

  2. Comparison of multiple linear regression, partial least squares and artificial neural networks for prediction of gas chromatographic relative retention times of trimethylsilylated anabolic androgenic steroids.

    PubMed

    Fragkaki, A G; Farmaki, E; Thomaidis, N; Tsantili-Kakoulidou, A; Angelis, Y S; Koupparis, M; Georgakopoulos, C

    2012-09-21

    The comparison among different modelling techniques, such as multiple linear regression, partial least squares and artificial neural networks, has been performed in order to construct and evaluate models for prediction of gas chromatographic relative retention times of trimethylsilylated anabolic androgenic steroids. The performance of the quantitative structure-retention relationship study, using the multiple linear regression and partial least squares techniques, has been previously conducted. In the present study, artificial neural networks models were constructed and used for the prediction of relative retention times of anabolic androgenic steroids, while their efficiency is compared with that of the models derived from the multiple linear regression and partial least squares techniques. For overall ranking of the models, a novel procedure [Trends Anal. Chem. 29 (2010) 101-109] based on sum of ranking differences was applied, which permits the best model to be selected. The suggested models are considered useful for the estimation of relative retention times of designer steroids for which no analytical data are available.

  3. Novel thrombolytic protease from edible and medicinal plant Aster yomena (Kitam.) Honda with anticoagulant activity: purification and partial characterization.

    PubMed

    Choi, Jun-Hui; Kim, Dae-Won; Park, Se-Eun; Choi, Bong-Suk; Sapkota, Kumar; Kim, Seung; Kim, Sung-Jun

    2014-10-01

    A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar molecular mass. The enzyme was active at high temperatures (50°C). The fibrinolytic activity of kitamase was strongly inhibited by EDTA, EGTA, TPCK and PMSF, inhibited by Zn(2+). The Km and Vmax values for substrate S-2251 were determined as 4.31 mM and 23.81 mM/mg respectively. It dissolved fibrin clot directly and specifically cleaved the α, Aα and γ-γ chains of fibrin and fibrinogen. In addition, kitamase delayed the coagulation time and increased activated partial thromboplastin time and prothrombin time. Kitamase exerted a significant protective effect against collagen and epinephrine induced pulmonary thromboembolism in mice. These results suggest that kitamase may have the property of metallo-protease like enzyme, novel fibrino(geno)lytic enzyme and a potential to be a therapeutic agent for thrombosis.

  4. On time discretizations for spectral methods. [numerical integration of Fourier and Chebyshev methods for dynamic partial differential equations

    NASA Technical Reports Server (NTRS)

    Gottlieb, D.; Turkel, E.

    1980-01-01

    New methods are introduced for the time integration of the Fourier and Chebyshev methods of solution for dynamic differential equations. These methods are unconditionally stable, even though no matrix inversions are required. Time steps are chosen by accuracy requirements alone. For the Fourier method both leapfrog and Runge-Kutta methods are considered. For the Chebyshev method only Runge-Kutta schemes are tested. Numerical calculations are presented to verify the analytic results. Applications to the shallow water equations are presented.

  5. Semi-online scheduling on two machines with GoS levels and partial information of processing time.

    PubMed

    Luo, Taibo; Xu, Yinfeng

    2014-01-01

    This paper investigates semi-online scheduling problems on two parallel machines under a grade of service (GoS) provision subject to minimize the makespan. We consider three different semi-online versions with knowing the total processing time of the jobs with higher GoS level, knowing the total processing time of the jobs with lower GoS level, or knowing both in advance. Respectively, for the three semi-online versions, we develop algorithms with competitive ratios of 3/2, 20/13, and 4/3 which are shown to be optimal.

  6. Measurement of time-dependent CP asymmetries and constraints on sin(2beta+gamma) with partial reconstruction of B0-->D*-/+pi+/- decays.

    PubMed

    Aubert, B; Barate, R; Boutigny, D; Couderc, F; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Ford, K; Harrison, T J; Hawkes, C M; Knowles, D J; Morgan, S E; Penny, R C; Watson, A T; Watson, N K; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmuecker, H; Steinke, M; Boyd, J T; Chevalier, N; Cottingham, W N; Kelly, M P; Latham, T E; Mackay, C; Wilson, F F; Abe, K; Cuhadar-Donszelmann, T; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Teodorescu, L; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Bruinsma, M; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hartfiel, B L; Gary, J W; Layter, J; Shen, B C; Wang, K; del Re, D; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beck, T W; Beringer, J; Eisner, A M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Spradlin, P; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Erwin, R J; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Abe, T; Blanc, F; Bloom, P; Chen, S; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, J; Schubert, K R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Grenier, P; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Andreotti, M; Azzolini, V; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Sarti, A; Treadwell, E; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Won, E; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Gaillard, J R; Morton, G W; Nash, J A; Taylor, G P; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Diberder, F Le; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Brigljević, V; Cheng, C H; Lange, D J; Simani, M C; Wright, D M; Bevan, A J; Coleman, J P; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Parry, R J; Payne, D J; Sloane, R J; Touramanis, C; Back, J J; Harrison, P F; Shorthouse, H W; Vidal, P B; Brown, C L; Cowan, G; Flack, R L; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Hart, P A; Hodgkinson, M C; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Saremi, S; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Cote-Ahern, D; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Pulliam, T; Wong, Q K; Brau, J; Frey, R; Igonkina, O; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; John, M J J; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Therin, G; Manfredi, P F; Re, V; Behera, P K; Gladney, L; Guo, Q H; Panetta, J; Anulli, F; Biasini, M; Peruzzi, I M; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Del Gamba, V; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Tanaka, H A; Varnes, E W; Bellini, F; Cavoto, G; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; SafaiTehrani, F; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; Legendre, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yeche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Cristinziani, M; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Elsen, E E; Field, R C; Glanzman, T; Gowdy, S J; Grauges-Pous, E; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Libby, J; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, P R; Edwards, A J; Meyer, T I; Petersen, B A; Roat, C; Ahmed, M; Ahmed, S; Alam, M S; Ernst, J A; Saeed, M A; Saleem, M; Wappler, F R; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Johnson, J R; Kutter, P E; Li, H; Liu, R; Di Lodovico, F; Mihalyi, A; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

    2004-06-25

    We present a measurement of time-dependent CP-violating asymmetries in decays of neutral B mesons to the final states D(*-/+)pi(+/-), using approximately 82x10(6) BBmacr; events recorded by the BABAR experiment at the PEP-II e(+)e(-) storage ring. Events containing these decays are selected with a partial reconstruction technique, in which only the high-momentum pi(+/-) from the B decay and the low-momentum pi(-/+) from the D(*-/+) decay are used. We measure the amplitude of the asymmetry to be -0.063+/-0.024(stat)+/-0.014(syst) and compute bounds on |sin((2beta+gamma)|.

  7. A fast direct method for block triangular Toeplitz-like with tri-diagonal block systems from time-fractional partial differential equations

    NASA Astrophysics Data System (ADS)

    Ke, Rihuan; Ng, Michael K.; Sun, Hai-Wei

    2015-12-01

    In this paper, we study the block lower triangular Toeplitz-like with tri-diagonal blocks system which arises from the time-fractional partial differential equation. Existing fast numerical solver (e.g., fast approximate inversion method) cannot handle such linear system as the main diagonal blocks are different. The main contribution of this paper is to propose a fast direct method for solving this linear system, and to illustrate that the proposed method is much faster than the classical block forward substitution method for solving this linear system. Our idea is based on the divide-and-conquer strategy and together with the fast Fourier transforms for calculating Toeplitz matrix-vector multiplication. The complexity needs O (MNlog2 ⁡ M) arithmetic operations, where M is the number of blocks (the number of time steps) in the system and N is the size (number of spatial grid points) of each block. Numerical examples from the finite difference discretization of time-fractional partial differential equations are also given to demonstrate the efficiency of the proposed method.

  8. Quantitative detection of Cucumber vein yellowing virus in susceptible and partially resistant plants using real-time PCR.

    PubMed

    Picó, Belén; Sifres, Alicia; Nuez, Fernando

    2005-09-01

    A method for the detection of Cucumber vein yellowing virus (CVYV) that combines reverse transcription with real-time PCR (SYBR((R)) Green chemistry) was developed using specific primers designed from a nucleotide sequence of the RNA polymerase gene (NIb) conserved among all the available CVYV strains. This method provided a linear assay over five to six orders of magnitude and reproducibly detected titres as low as 10(3) molecules of the target CVYV cDNA. Real-time PCR gave reproducible results for the quantification of CVYV in young leaves of susceptible and resistant cucumber landraces after mechanical inoculation. Significant differences in the starting amount of target cDNA were found between the analyzed genotypes, indicating differences in viral accumulation that correlated to their different levels of resistance. Real-time PCR results validated our previous findings using slot-blot hybridization, the dominance of the strong resistance to CVYV displayed by C.sat 10, and provided improved reliability and sensitivity of detection. This method has great potential in resistance breeding for germplasm screening, characterization of resistance mechanisms and genetic studies.

  9. Computing short-interval transition matrices of a discrete-time Markov chain from partially observed data.

    PubMed

    Charitos, Theodore; de Waal, Peter R; van der Gaag, Linda C

    2008-03-15

    Markov chains constitute a common way of modelling the progression of a chronic disease through various severity states. For these models, a transition matrix with the probabilities of moving from one state to another for a specific time interval is usually estimated from cohort data. Quite often, however, the cohort is observed at specific times with intervals that may be greater than the interval of interest. The transition matrix computed then needs to be decomposed in order to estimate the desired interval transition matrix suited to the model. Although simple to implement, this method of matrix decomposition can yet result in an invalid short-interval transition matrix with negative or complex entries. In this paper, we present a method for computing short-interval transition matrices that is based on regularization techniques. Our method operates separately on each row of the invalid short-interval transition matrix aiming to minimize an appropriate distance measure. We test our method on various matrix structures and sizes, and evaluate its performance on a real-life transition model for HIV-infected individuals. PMID:17579926

  10. Partial trisomy of distal 19q detected by quantitative real-time PCR and FISH in a girl with mild facial dysmorphism, hypotonia and developmental delay.

    PubMed

    Sauter, S M; Böhm, Detlef; Bartels, Iris; Burfeind, Peter; Laccone, Franco A; Neesen, Jürgen; Wilken, Bernd; Liehr, Thomas; Zoll, Barbara

    2007-05-15

    We report on a 2 7/12-year-old girl who was referred to us because of psychomotor developmental delay. She is the second child of healthy, non-consanguineous parents. Pregnancy and birth were uneventful. Milestones of motor development were delayed: grasping at 6 months, sitting without support at 16 months, crawling at 16 months and walking at 2 4/12 years of age. She spoke about five words and followed simple instructions. Banding cytogenetics revealed a numerically and structurally normal female karyotype of 46,XX. By quantitative real-time PCR analysis of all subtelomeric regions, a partial trisomy of the subtelomeric region of 19q could be detected. This result was confirmed by FISH-analysis with a subtelomeric probe for 19q. The additional material of chromosome 19q was localized on chromosome 6q. However, a deletion of the subtelomeric region of 6q could not be detected with a subtelomeric FISH probe for 6q. Conventional cytogenetic analysis as well as FISH with subtelomeric probes for 19q and 6q showed normal results in the parents. The detected chromosomal aberration probably occurred de novo. The clinical features are very likely to be caused solely by the partial trisomy 19q.

  11. Epilepsy (partial)

    PubMed Central

    2011-01-01

    Introduction About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy eventually go into remission. Methods and outcomes We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of starting antiepileptic drug treatment following a single seizure? What are the effects of drug monotherapy in people with partial epilepsy? What are the effects of additional drug treatments in people with drug-resistant partial epilepsy? What is the risk of relapse in people in remission when withdrawing antiepileptic drugs? What are the effects of behavioural and psychological treatments for people with epilepsy? What are the effects of surgery in people with drug-resistant temporal lobe epilepsy? We searched: Medline, Embase, The Cochrane Library, and other important databases up to July 2009 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). Results We found 83 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. Conclusions In this systematic review we present information relating to the effectiveness and safety of the following interventions: antiepileptic drugs after a single seizure; monotherapy for partial epilepsy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs for drug-resistant partial epilepsy (allopurinol, eslicarbazepine, gabapentin, lacosamide, lamotrigine, levetiracetam, losigamone, oxcarbazepine, retigabine, tiagabine, topiramate, vigabatrin, or zonisamide); antiepileptic drug withdrawal for people with partial or

  12. Measurements of time-dependent CP asymmetries in B→D*∓π± decays using a partial reconstruction technique

    SciTech Connect

    Bahinipati, S.; Trabelsi, K.; Kinoshita, K.; Arinstein, K.; Aulchenko, V.; Aushev, T.; Bakich, A. M.; Balagura, V.; Barberio, E.; Belous, K.; Bhardwaj, V.; Bhuyan, B.; Bischofberger, M.; Bondar, A.; Bozek, A.; Bračko, M.; Chen, A.; Chen, P.; Cheon, B. G.; Chiang, C.-C.; Cho, I.-S.; Cho, K.; Choi, Y.; Dalseno, J.; Doležal, Z.; Drásal, Z.; Eidelman, S.; Gabyshev, N.; Golob, B.; Ha, H.; Horii, Y.; Hoshi, Y.; Hou, W.-S.; Hsiung, Y. B.; Hyun, H. J.; Ishikawa, A.; Iwabuchi, M.; Iwasaki, Y.; Iwashita, T.; Julius, T.; Kang, J. H.; Kiesling, C.; Kim, H. J.; Kim, M. J.; Ko, B. R.; Kobayashi, N.; Kodyš, P.; Križan, P.; Kumita, T.; Kwon, Y.-J.; Kyeong, S.-H.; Lange, J. S.; Lee, M. J.; Lee, S.-H.; Li, J.; Liu, C.; Louvot, R.; Matyja, A.; McOnie, S.; Miyabayashi, K.; Miyata, H.; Miyazaki, Y.; Mohanty, G. B.; Nakao, M.; Natkaniec, Z.; Neubauer, S.; Nishida, S.; Nitoh, O.; Ogawa, S.; Ohshima, T.; Pakhlov, P.; Park, C. W.; Petrič, M.; Piilonen, L. E.; Poluektov, A.; Röhrken, M.; Sahoo, H.; Sakai, Y.; Schneider, O.; Schwanda, C.; Schwartz, A. J.; Sevior, M. E.; Shapkin, M.; Shen, C. P.; Shiu, J.-G.; Smerkol, P.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Stanič, S.; Starič, M.; Sumisawa, K.; Sumiyoshi, T.; Tanaka, S.; Teramoto, Y.; Uchida, M.; Uehara, S.; Uglov, T.; Unno, Y.; Uno, S.; Varner, G.; Vinokurova, A.; Wang, C. H.; Won, E.; Yabsley, B. D.; Yamashita, Y.; Zhang, C. C.; Zhang, Z. P.; Zhou, P.; Zivko, T.; Zupanc, A.

    2011-07-05

    We report results on time-dependent CP asymmetries in B→D*∓π± decays based on a data sample containing 657×10⁶ BB¯ pairs collected with the Belle detector at the KEKB asymmetric-energy e⁺e⁻ collider at the Υ(4S) resonance. We use a partial reconstruction technique, wherein signal B→D*∓π± events are identified using information only from the fast pion from the B decay and the slow pion from the subsequent decay of the D*∓, where the former (latter) corresponds to D*⁺(D*⁻) final states. We obtain CP violation parameters S⁺=+0.061±0.018 (stat)±0.012 (syst) and S⁻=+0.031±0.019 (stat)±0.015 (syst).

  13. Simulations for Full Unit-memory and Partial Unit-memory Convolutional Codes with Real-time Minimal-byte-error Probability Decoding Algorithm

    NASA Technical Reports Server (NTRS)

    Vo, Q. D.

    1984-01-01

    A program which was written to simulate Real Time Minimal-Byte-Error Probability (RTMBEP) decoding of full unit-memory (FUM) convolutional codes on a 3-bit quantized AWGN channel is described. This program was used to compute the symbol-error probability of FUM codes and to determine the signal to noise (SNR) required to achieve a bit error rate (BER) of 10 to the minus 6th power for corresponding concatenated systems. A (6,6/30) FUM code, 6-bit Reed-Solomon code combination was found to achieve the required BER at a SNR of 1.886 dB. The RTMBEP algorithm was then modified for decoding partial unit-memory (PUM) convolutional codes. A simulation program was also written to simulate the symbol-error probability of these codes.

  14. Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters

    PubMed Central

    Wu, Hulin; Miao, Hongyu; Xue, Hongqi; Topham, David J.; Zand, Martin

    2014-01-01

    Summary Influenza A virus (IAV) infection continues to be a global health threat, as evidenced by the outbreak of the novel A/California/7/2009 IAV strain. Previous flu vaccines have proven less effective than hoped for emerging IAV strains, indicating a more thorough understanding of immune responses to primary infection is needed. One issue is the difficulty in directly measuring many key parameters and variables of the immune response. To address these issues, we considered a comprehensive workflow for statistical inference for ordinary differential question (ODE) models with partially observed variables and time-varying parameters, including identifiability analysis, two-stage and NLS estimation, and model selection etc‥ In particular, we proposed a novel one-step method to verify parameter identifiability and formulate estimating equations simultaneously. Thus, the pseudo-LS method can now deal with general ODE models with partially observed state variables for the first time. Using this workflow, we verified the relative significance of various immune factors to virus control, including target epithelial cells, cytotoxic T-lymphocyte (CD8+) cells and IAV specific antibodies (IgG and IgM). Factors other than cytotoxic T-lymphocyte (CTL) killing contributed the most to the loss of infected epithelial cells, though the effects of CTL are still significant. IgM antibody was found to be the major contributor to neutralization of free infectious viral particles. Also, the maximum viral load, which correlates well with mortality, was found to depend more on viral replication rates than infectivity. In contrast to current hypotheses, the results obtained via our methods suggest that IgM antibody and viral replication rates may be worth of further explorations in vaccine development. PMID:26085850

  15. Performance comparison of partial least squares-related variable selection methods for quantitative structure retention relationships modelling of retention times in reversed-phase liquid chromatography.

    PubMed

    Talebi, Mohammad; Schuster, Georg; Shellie, Robert A; Szucs, Roman; Haddad, Paul R

    2015-12-11

    The relative performance of six multivariate data analysis methods derived from or combined with partial least squares (PLS) has been compared in the context of quantitative structure-retention relationships (QSRR). These methods include, GA (genetic algorithm)-PLS, Monte Carlo uninformative variable elimination (MC-UVE), competitive adaptive reweighted sampling (CARS), iteratively retaining informative variables (IRIV), variable iterative space shrinkage approach (VISSA) and PLS with automated backward selection of predictors (autoPLS). A set of 825 molecular descriptors was computed for 86 suspected sports doping compounds and used for predicting their gradient retention times in reversed-phase liquid chromatography (RPLC). The correlation between molecular descriptors selected by each technique and the retention time was established using the PLS method. All models derived from a selected subset of descriptors outperformed the reference PLS model derived from all descriptors, with very small demands of computational time and effort. A performance comparison indicated great diversity of these methods in selecting the most relevant molecular descriptors, ranging from 28 for CARS to 263 for MC-UVE. While VISSA provided the lowest degree of over-fitting for the training set, CARS demonstrated the best compromise between the prediction accuracy and the number of selected descriptors, with the prediction error of as low as 46s for the external test set. Only ten descriptors were found to be common for all models, with the characteristics of these descriptors being representative of the retention mechanism in RPLC.

  16. Partial correlation between lower muscle thickness, 10-meter walk test, and the timed up & go test in children with spastic cerebral palsy

    PubMed Central

    Yun, Chang-Kyo; Kim, Won-hyo; Kim, Seong-Gil

    2016-01-01

    [Purpose] The purpose of this study was to examine the correlation between lower extremity muscle thickness and gait ability through the 10-meter walk and timed up and go tests. [Subjects and Methods] A total of 28 children (20 males and 8 females) with spastic cerebral palsy undergoing physical therapy at D hospital in D city, South Korea participated in this study. Partial correlation analysis was performed to analyze the correlation between lower extremity muscle thickness and gait ability (10-meter walk test and timed up and go test). [Results] There was a positive correlation between muscle thickness and the 10-meter walk test (RF=0.41 and VL=0.52). Correlation between the muscle thickness and the timed up and go had a negative correlation (VL=−0.45, MG=−0.51, and LG=−0.39). [Conclusion] In children with cerebral palsy, knee extensor muscles that are more developed increased gait ability and calf muscles that are more developed increased sit to stand ability. PMID:27313383

  17. Towards multiple hazard resilient bridges: a methodology for modeling frequent and infrequent time-varying loads Part I, Comprehensive reliability and partial failure probabilities

    NASA Astrophysics Data System (ADS)

    Liang, Zach; Lee, George C.

    2012-09-01

    The current AASHTO load and resistance factor design (LRFD) guidelines are formulated based on bridge reliability, which interprets traditional design safety factors into more rigorously deduced factors based on the theory of probability. This is a major advancement in bridge design specifications. However, LRFD is only calibrated for dead and live loads. In cases when extreme loads are significant, they need to be individually assessed. Combining regular loads with extreme loads has been a major challenge, mainly because the extreme loads are time variables and cannot be directly combined with time invariant loads to formulate the probability of structural failure. To overcome these difficulties, this paper suggests a methodology of comprehensive reliability, by introducing the concept of partial failure probability to separate the loads so that each individual load combination under a certain condition can be approximated as time invariant. Based on these conditions, the extreme loads (also referred to as multiple hazard or MH loads) can be broken down into single effects. In Part II of this paper, a further breakdown of these conditional occurrence probabilities into pure conditions is discussed by using a live truck and earthquake loads on a bridge as an example. There are three major steps in establishing load factors from MH load distributions: (1) formulate the failure probabilities; (2) normalize various load distributions; and (3) establish design limit state equations. This paper describes the formulation of the failure probabilities of single and combined loads.

  18. Robot-assisted partial nephrectomy: Superiority over laparoscopic partial nephrectomy.

    PubMed

    Shiroki, Ryoichi; Fukami, Naohiko; Fukaya, Kosuke; Kusaka, Mamoru; Natsume, Takahiro; Ichihara, Takashi; Toyama, Hiroshi

    2016-02-01

    Nephron-sparing surgery has been proven to positively impact the postoperative quality of life for the treatment of small renal tumors, possibly leading to functional improvements. Laparoscopic partial nephrectomy is still one of the most demanding procedures in urological surgery. Laparoscopic partial nephrectomy sometimes results in extended warm ischemic time and severe complications, such as open conversion, postoperative hemorrhage and urine leakage. Robot-assisted partial nephrectomy exploits the advantages offered by the da Vinci Surgical System to laparoscopic partial nephrectomy, equipped with 3-D vision and a better degree in the freedom of surgical instruments. The introduction of the da Vinci Surgical System made nephron-sparing surgery, specifically robot-assisted partial nephrectomy, safe with promising results, leading to the shortening of warm ischemic time and a reduction in perioperative complications. Even for complex and challenging tumors, robotic assistance is expected to provide the benefit of minimally-invasive surgery with safe and satisfactory renal function. Warm ischemic time is the modifiable factor during robot-assisted partial nephrectomy to affect postoperative kidney function. We analyzed the predictive factors for extended warm ischemic time from our robot-assisted partial nephrectomy series. The surface area of the tumor attached to the kidney parenchyma was shown to significantly affect the extended warm ischemic time during robot-assisted partial nephrectomy. In cases with tumor-attached surface area more than 15 cm(2) , we should consider switching robot-assisted partial nephrectomy to open partial nephrectomy under cold ischemia if it is imperative. In Japan, a nationwide prospective study has been carried out to show the superiority of robot-assisted partial nephrectomy to laparoscopic partial nephrectomy in improving warm ischemic time and complications. By facilitating robotic technology, robot-assisted partial nephrectomy

  19. Sensitized luminescence from water-soluble LaF3:Eu nanocrystals via partially-capped 1,10-phenanthroline: time-gated emission and multiple lifetimes.

    PubMed

    Irfanullah, Mir; Bhardwaj, Navneet; Chowdhury, Arindam

    2016-08-01

    Water dispersible citrate-capped LaF3:Eu(5%) nanocrystals (NCs) have been partially surface-functionalized by 1,10-phenanthroline (phen) via a ligand exchange method to produce novel water dispersed citrate/phen-capped LaF3:Eu(5%) NCs in which citrate ligands preserve the water dispersibility of the NCs and phen ligands act as sensitizers of surface Eu(3+)-dopant sites. The partial ligand exchange and the formation of water dispersed NCs have been monitored by (1)H NMR spectroscopy, as well as luminescence measurements at different time intervals during the reaction. These NCs display a distinct phen-sensitized Eu(3+)-emission profile with enhanced intensity in water as compared to the emission profile and intensity obtained upon direct excitation. Time-resolved (or time-gated) emission spectroscopy (TRES) has been used to probe PL dynamics of Eu(3+)-sites of LaF3:Eu(5%) NCs by taking advantage of selectively sensitizing surface Eu(3+)-dopant sites by phen ligands as well as by exciting all the Eu(3+)-sites in the NCs upon direct excitation. TRES upon direct excitation of the citrate-capped LaF3:Eu(5%) NCs reveals that Eu(3+)-dopants occupy at least three different sites, each with a different emission profile and lifetime, and emission from purely interior Eu(3+)-sites has been resolved due to their long lifetime as compared to the lifetime of purely surface and near surface Eu(3+)-sites. In contrast, the phen-sensitized emission from citrate/phen-capped LaF3:Eu(5%) NCs displays similar emission profiles and lifetimes in TRES measurements, which reveal that phen truly sensitizes purely surface dopant sites of the NCs in water, all of which have nearly the same local environment. The phen-sensitized Eu(3+)-emission of the NCs in water remains stable even upon addition of various buffer solutions at physiological pH, as well as upon addition of water-miscible organic solvents. Furthermore, the two-photon excitation (λex. = 720 nm) of these water-soluble phen

  20. A novel real-time reverse transcription-polymerase chain reaction assay with partially double-stranded linear DNA probe for sensitive detection of hepatitis C viral RNA.

    PubMed

    Liu, Tianfu; Wan, Zhenzhou; Liu, Jia; Zhang, Lingyi; Zhou, Yanheng; Lan, Ke; Hu, Yihong; Zhang, Chiyu

    2016-10-01

    The detection and quantification of HCV RNA is very helpful for the management and treatment of HCV related diseases. Detection of low HCV viral load is a great challenge in HCV RNA detection. Here, we developed a novel real-time RT-PCR assay with partially double-stranded linear DNA probe which can detect all HCV genotypes and improve the detection performance. The novel assay has a wide linear dynamic range of HCV RNA quantification (1×10(2)-1×10(11)IU/ml) and a limit of detection of 78IU/ml. The assay exhibits an excellent reproducibility with 2.52% and 1.33% coefficients of variations, for inter- and intra-assays, respectively. To evaluate the viability of the assay, a comparison with a commercial HCV RNA detection kit was performed using 106 serum samples. The lineared correlation coefficient between the novel assay and the commercial HCV RNA detection kit was 0.940. Meanwhile, the deviation between the two methods was tolerable. Therefore, the novel real-time RT-PCR assay was applicable for laboratory diagnosis and monitoring of HCV infection. PMID:27451264

  1. Partially Hydrated Electrons at the Air/Water Interface Observed by UV-Excited Time-Resolved Heterodyne-Detected Vibrational Sum Frequency Generation Spectroscopy.

    PubMed

    Matsuzaki, Korenobu; Kusaka, Ryoji; Nihonyanagi, Satoshi; Yamaguchi, Shoichi; Nagata, Takashi; Tahara, Tahei

    2016-06-22

    Hydrated electrons are the most fundamental anion species, consisting only of electrons and surrounding water molecules. Although hydrated electrons have been extensively studied in the bulk aqueous solutions, even their existence is still controversial at the water surface. Here, we report the observation and characterization of hydrated electrons at the air/water interface using new time-resolved interface-selective nonlinear vibrational spectroscopy. With the generation of electrons at the air/water interface by ultraviolet photoirradiation, we observed the appearance of a strong transient band in the OH stretch region by heterodyne-detected vibrational sum-frequency generation. Through the comparison with the time-resolved spectra at the air/indole solution interface, the transient band was assigned to the vibration of water molecules that solvate electrons at the interface. The analysis of the frequency and decay of the observed transient band indicated that the electrons are only partially hydrated at the water surface, and that they escape into the bulk within 100 ps. PMID:27281547

  2. An Ultrahigh Frequency Partial Discharge Signal De-Noising Method Based on a Generalized S-Transform and Module Time-Frequency Matrix

    PubMed Central

    Liu, Yushun; Zhou, Wenjun; Li, Pengfei; Yang, Shuai; Tian, Yan

    2016-01-01

    Due to electromagnetic interference in power substations, the partial discharge (PD) signals detected by ultrahigh frequency (UHF) antenna sensors often contain various background noises, which may hamper high voltage apparatus fault diagnosis and localization. This paper proposes a novel de-noising method based on the generalized S-transform and module time-frequency matrix to suppress noise in UHF PD signals. The sub-matrix maximum module value method is employed to calculate the frequencies and amplitudes of periodic narrowband noise, and suppress noise through the reverse phase cancellation technique. In addition, a singular value decomposition de-noising method is employed to suppress Gaussian white noise in UHF PD signals. Effective singular values are selected by employing the fuzzy c-means clustering method to recover the PD signals. De-noising results of simulated and field detected UHF PD signals prove the feasibility of the proposed method. Compared with four conventional de-noising methods, the results show that the proposed method can suppress background noise in the UHF PD signal effectively, with higher signal-to-noise ratio and less waveform distortion. PMID:27338409

  3. An Ultrahigh Frequency Partial Discharge Signal De-Noising Method Based on a Generalized S-Transform and Module Time-Frequency Matrix.

    PubMed

    Liu, Yushun; Zhou, Wenjun; Li, Pengfei; Yang, Shuai; Tian, Yan

    2016-01-01

    Due to electromagnetic interference in power substations, the partial discharge (PD) signals detected by ultrahigh frequency (UHF) antenna sensors often contain various background noises, which may hamper high voltage apparatus fault diagnosis and localization. This paper proposes a novel de-noising method based on the generalized S-transform and module time-frequency matrix to suppress noise in UHF PD signals. The sub-matrix maximum module value method is employed to calculate the frequencies and amplitudes of periodic narrowband noise, and suppress noise through the reverse phase cancellation technique. In addition, a singular value decomposition de-noising method is employed to suppress Gaussian white noise in UHF PD signals. Effective singular values are selected by employing the fuzzy c-means clustering method to recover the PD signals. De-noising results of simulated and field detected UHF PD signals prove the feasibility of the proposed method. Compared with four conventional de-noising methods, the results show that the proposed method can suppress background noise in the UHF PD signal effectively, with higher signal-to-noise ratio and less waveform distortion. PMID:27338409

  4. Off-Stream Watering Systems and Partial Barriers as a Strategy to Maximize Cattle Production and Minimize Time Spent in the Riparian Area

    PubMed Central

    Rawluk, Ashley A.; Crow, Gary; Legesse, Getahun; Veira, Douglas M.; Bullock, Paul R.; González, Luciano A.; Dubois, Melanie; Ominski, Kim H.

    2014-01-01

    Simple Summary The implementation of off-stream waterers (OSW) may reduce the amount of time cattle spend in riparian areas, thus minimizing impacts such as removal of vegetation, soil compaction, and deterioration in water quality. Furthermore, when used with natural barriers as a partial exclusion method, these management strategies may offer a cost-effective alternative to completely excluding cattle via streambank fencing. This study was conducted to determine the impact of OSW and barriers on animal performance and watering behavior. The presence of OSW had no significant effect on cow and calf weights averaged over the grazing season. Although the results were not consistent over the periods and locations, the data provided some indication of the efficacy of the natural barriers on deterring cattle from the riparian area. Cattle watered at the OSW when available, but they did not use the OSW exclusively. The observed inconsistency may, in part, be attributed to the environmental conditions present during this field trial. Abstract A study was conducted in 2009 at two locations in Manitoba (Killarney and Souris), Canada to determine the impact of off-stream waterers (OSW) with or without natural barriers on (i) amount of time cattle spent in the 10 m buffer created within the riparian area, referred to as the riparian polygon (RP), (ii) watering location (OSW or stream), and (iii) animal performance measured as weight gain. This study was divided into three 28-day periods over the grazing season. At each location, the pasture—which ranged from 21.0 ha to 39.2 ha in size—was divided into three treatments: no OSW nor barriers (1CONT), OSW with barriers along the stream bank to deter cattle from watering at the stream (2BARR), and OSW without barriers (3NOBARR). Cattle in 2BARR spent less time in the RP in Periods 1 (p = 0.0002), 2 (p = 0.1116), and 3 (p < 0.0001) at the Killarney site compared to cattle in 3NOBARR at the same site. Cattle in 2BARR at the

  5. Partially supervised P300 speller adaptation for eventual stimulus timing optimization: target confidence is superior to error-related potential score as an uncertain label

    NASA Astrophysics Data System (ADS)

    Zeyl, Timothy; Yin, Erwei; Keightley, Michelle; Chau, Tom

    2016-04-01

    Objective. Error-related potentials (ErrPs) have the potential to guide classifier adaptation in BCI spellers, for addressing non-stationary performance as well as for online optimization of system parameters, by providing imperfect or partial labels. However, the usefulness of ErrP-based labels for BCI adaptation has not been established in comparison to other partially supervised methods. Our objective is to make this comparison by retraining a two-step P300 speller on a subset of confident online trials using naïve labels taken from speller output, where confidence is determined either by (i) ErrP scores, (ii) posterior target scores derived from the P300 potential, or (iii) a hybrid of these scores. We further wish to evaluate the ability of partially supervised adaptation and retraining methods to adjust to a new stimulus-onset asynchrony (SOA), a necessary step towards online SOA optimization. Approach. Eleven consenting able-bodied adults attended three online spelling sessions on separate days with feedback in which SOAs were set at 160 ms (sessions 1 and 2) and 80 ms (session 3). A post hoc offline analysis and a simulated online analysis were performed on sessions two and three to compare multiple adaptation methods. Area under the curve (AUC) and symbols spelled per minute (SPM) were the primary outcome measures. Main results. Retraining using supervised labels confirmed improvements of 0.9 percentage points (session 2, p < 0.01) and 1.9 percentage points (session 3, p < 0.05) in AUC using same-day training data over using data from a previous day, which supports classifier adaptation in general. Significance. Using posterior target score alone as a confidence measure resulted in the highest SPM of the partially supervised methods, indicating that ErrPs are not necessary to boost the performance of partially supervised adaptive classification. Partial supervision significantly improved SPM at a novel SOA, showing promise for eventual online SOA

  6. Modeling RP-1 fuel advanced distillation data using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry and partial least squares analysis.

    PubMed

    Kehimkar, Benjamin; Parsons, Brendon A; Hoggard, Jamin C; Billingsley, Matthew C; Bruno, Thomas J; Synovec, Robert E

    2015-01-01

    Recent efforts in predicting rocket propulsion (RP-1) fuel performance through modeling put greater emphasis on obtaining detailed and accurate fuel properties, as well as elucidating the relationships between fuel compositions and their properties. Herein, we study multidimensional chromatographic data obtained by comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC × GC-TOFMS) to analyze RP-1 fuels. For GC × GC separations, RTX-Wax (polar stationary phase) and RTX-1 (non-polar stationary phase) columns were implemented for the primary and secondary dimensions, respectively, to separate the chemical compound classes (alkanes, cycloalkanes, aromatics, etc.), providing a significant level of chemical compositional information. The GC × GC-TOFMS data were analyzed using partial least squares regression (PLS) chemometric analysis to model and predict advanced distillation curve (ADC) data for ten RP-1 fuels that were previously analyzed using the ADC method. The PLS modeling provides insight into the chemical species that impact the ADC data. The PLS modeling correlates compositional information found in the GC × GC-TOFMS chromatograms of each RP-1 fuel, and their respective ADC, and allows prediction of the ADC for each RP-1 fuel with good precision and accuracy. The root-mean-square error of calibration (RMSEC) ranged from 0.1 to 0.5 °C, and was typically below ∼0.2 °C, for the PLS calibration of the ADC modeling with GC × GC-TOFMS data, indicating a good fit of the model to the calibration data. Likewise, the predictive power of the overall method via PLS modeling was assessed using leave-one-out cross-validation (LOOCV) yielding root-mean-square error of cross-validation (RMSECV) ranging from 1.4 to 2.6 °C, and was typically below ∼2.0 °C, at each % distilled measurement point during the ADC analysis.

  7. Recalcification Time in Breast Disease

    PubMed Central

    Sofia, Carmela A.; Spillert, Charles R.; Pastena, Janis A.; Lazaro, Eric J.

    1988-01-01

    Hypercoagulability in malignant disease can be attributed, in part, to excess generation of tissue factor (thromboplastin) by the monocyte. Incubation of anticoagulated venous blood with endotoxin (a cellular activator) enables the generation of tissue factor by monocytes. The quantity of this procoagulant generated is determined by a simple recalcification time (a marker for cellular activation). Individuals with breast cancer have significantly shorter endotoxin-activated recalcification times than patients with cystic hyperplasia, who have, in turn, significantly reduced recalcification times when compared with those of healthy volunteers. PMID:3249326

  8. Partially coherent ultrafast spectrography

    PubMed Central

    Bourassin-Bouchet, C.; Couprie, M.-E.

    2015-01-01

    Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, that is, that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sources where temporal metrology is strongly needed. Here we demonstrate how frequency-resolved optical gating (FROG), the first and one of the most widespread techniques for pulse characterization, can be adapted to measure partially coherent pulses even down to the attosecond timescale. No modification of experimental apparatuses is required; only the processing of the measurement changes. To do so, we take our inspiration from other branches of physics where partial coherence is routinely dealt with, such as quantum optics and coherent diffractive imaging. This will have important and immediate applications, such as enabling the measurement of X-ray free-electron laser pulses despite timing jitter. PMID:25744080

  9. Partially coherent ultrafast spectrography

    NASA Astrophysics Data System (ADS)

    Bourassin-Bouchet, C.; Couprie, M.-E.

    2015-03-01

    Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, that is, that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sources where temporal metrology is strongly needed. Here we demonstrate how frequency-resolved optical gating (FROG), the first and one of the most widespread techniques for pulse characterization, can be adapted to measure partially coherent pulses even down to the attosecond timescale. No modification of experimental apparatuses is required; only the processing of the measurement changes. To do so, we take our inspiration from other branches of physics where partial coherence is routinely dealt with, such as quantum optics and coherent diffractive imaging. This will have important and immediate applications, such as enabling the measurement of X-ray free-electron laser pulses despite timing jitter.

  10. PT and INR Test

    MedlinePlus

    ... Time ; Partial Thromboplastin Time ; Prothrombin Consumption Time; Fibrinogen ; Coagulation Factors ; Platelet Count ; Platelet Function Tests ; Thrombin Time ; ... thinning medication ( anticoagulant ) warfarin (Coumadin®). Several proteins called coagulation factors are involved in the process that the ...

  11. 5 CFR 831.612 - Election at time of retirement of a fully reduced annuity or a partially reduced annuity to...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Election at time of retirement of a fully... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.612 Election at time of retirement...

  12. 5 CFR 831.612 - Election at time of retirement of a fully reduced annuity or a partially reduced annuity to...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Election at time of retirement of a fully... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.612 Election at time of retirement...

  13. 5 CFR 831.612 - Election at time of retirement of a fully reduced annuity or a partially reduced annuity to...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Election at time of retirement of a fully... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.612 Election at time of retirement...

  14. 5 CFR 831.612 - Election at time of retirement of a fully reduced annuity or a partially reduced annuity to...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 2 2014-01-01 2014-01-01 false Election at time of retirement of a fully... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.612 Election at time of retirement...

  15. 5 CFR 831.612 - Election at time of retirement of a fully reduced annuity or a partially reduced annuity to...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Election at time of retirement of a fully... Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Elections at the Time of Retirement § 831.612 Election at time of retirement...

  16. Partial oxidation catalyst

    DOEpatents

    Krumpelt, Michael; Ahmed, Shabbir; Kumar, Romesh; Doshi, Rajiv

    2000-01-01

    A two-part catalyst comprising a dehydrogenation portion and an oxide-ion conducting portion. The dehydrogenation portion is a group VIII metal and the oxide-ion conducting portion is selected from a ceramic oxide crystallizing in the fluorite or perovskite structure. There is also disclosed a method of forming a hydrogen rich gas from a source of hydrocarbon fuel in which the hydrocarbon fuel contacts a two-part catalyst comprising a dehydrogenation portion and an oxide-ion conducting portion at a temperature not less than about 400.degree. C. for a time sufficient to generate the hydrogen rich gas while maintaining CO content less than about 5 volume percent. There is also disclosed a method of forming partially oxidized hydrocarbons from ethanes in which ethane gas contacts a two-part catalyst comprising a dehydrogenation portion and an oxide-ion conducting portion for a time and at a temperature sufficient to form an oxide.

  17. Partial (focal) seizure

    MedlinePlus

    ... Jacksonian seizure; Seizure - partial (focal); Temporal lobe seizure; Epilepsy - partial seizures ... Abou-Khalil BW, Gallagher MJ, Macdonald RL. Epilepsies. In: Daroff ... Practice . 7th ed. Philadelphia, PA: Elsevier; 2016:chap 101. ...

  18. Partial tooth gear bearings

    NASA Technical Reports Server (NTRS)

    Vranish, John M. (Inventor)

    2010-01-01

    A partial gear bearing including an upper half, comprising peak partial teeth, and a lower, or bottom, half, comprising valley partial teeth. The upper half also has an integrated roller section between each of the peak partial teeth with a radius equal to the gear pitch radius of the radially outwardly extending peak partial teeth. Conversely, the lower half has an integrated roller section between each of the valley half teeth with a radius also equal to the gear pitch radius of the peak partial teeth. The valley partial teeth extend radially inwardly from its roller section. The peak and valley partial teeth are exactly out of phase with each other, as are the roller sections of the upper and lower halves. Essentially, the end roller bearing of the typical gear bearing has been integrated into the normal gear tooth pattern.

  19. Comparison of TiO₂ and ZnO solar cells sensitized with an indoline dye: time-resolved laser spectroscopy studies of partial charge separation processes.

    PubMed

    Sobuś, Jan; Burdziński, Gotard; Karolczak, Jerzy; Idígoras, Jesús; Anta, Juan A; Ziółek, Marcin

    2014-03-11

    Time-resolved laser spectroscopy techniques in the time range from femtoseconds to seconds were applied to investigate the charge separation processes in complete dye-sensitized solar cells (DSC) made with iodide/iodine liquid electrolyte and indoline dye D149 interacting with TiO2 or ZnO nanoparticles. The aim of the studies was to explain the differences in the photocurrents of the cells (3-4 times higher for TiO2 than for ZnO ones). Electrochemical impedance spectroscopy and nanosecond flash photolysis studies revealed that the better performance of TiO2 samples is not due to the charge collection and dye regeneration processes. Femtosecond transient absorption results indicated that after first 100 ps the number of photoinduced electrons in the semiconductor is 3 times higher for TiO2 than for ZnO solar cells. Picosecond emission studies showed that the lifetime of the D149 excited state is about 3 times longer for ZnO than for TiO2 samples. Therefore, the results indicate that lower performance of ZnO solar cells is likely due to slower electron injection. The studies show how to correlate the laser spectroscopy methodology with global parameters of the solar cells and should help in better understanding of the behavior of alternative materials for porous electrodes for DSC and related devices.

  20. Factor VII deficiency

    MedlinePlus

    ... may be done include: Partial thromboplastin time ( PTT ) Plasma factor VII activity Prothrombin time ( PT ) Mixing study ... controlled by getting intravenous (IV) infusions of normal plasma, concentrates of factor VII, or genetically produced (recombinant) ...

  1. Clotting profiles and selected hematology of captive Speke's gazelles (Gazella spekei).

    PubMed

    Travis, Erika K; Eby, Charles

    2006-03-01

    Manual restraint and jugular venipuncture were used to obtain blood for hematology and coagulation tests for 18 captive Speke's gazelles (Gazella spekei). The hematocrit and hemoglobin values were slightly higher in Speke's gazelles than in domestic ruminants. The Speke's gazelles had a mean prothrombin time of 15.1 sec and a mean activated partial thromboplastin time of 24.2 sec. The pregnant female Speke's gazelles had shorter activated partial thromboplastin times than the males, but the difference was not significant. Ideally, prothrombin times and activated partial thromboplastin times would be compared to a healthy conspecific during a suspected bleeding crisis. Baseline prothrombin and activated partial thromboplastin times are presented here for Speke's gazelles because clotting times for exotic hoofstock are quite limited. PMID:17312817

  2. Time-independent states of a non-neutral plasma diode when emitted electrons are partially turned around by a transverse magnetic field

    NASA Astrophysics Data System (ADS)

    Pramanik, Sourav; Kuznetsov, V. I.; Gerasimenko, A. B.; Chakrabarti, Nikhil

    2016-10-01

    An analytical study is presented on the steady states of a plasma diode that is uniformly occupied by infinitely massive ions of constant density and driven by a cold electron beam in the presence of an external transverse magnetic field. In contrast to our previous work [Pramanik et al., Phys. Plasmas 23, 062118 (2016)], here, we investigate the case when electrons are reflected back to the emitter by the magnetic field for arbitrary values of the neutralization parameter. Using the emitter electric field as a characteristic parameter, the steady-state solutions have been evaluated for the specific values of the diode gap, applied voltage, neutralization parameter, and magnetic field strength. It was found that unlike vacuum diodes (e.g., the Bursian diode), steady state solutions also exist for negative values of the emitter field strength. In case of the Bursian diode, only a single type of solutions (Bursian branches) was observed. However, for the Pierce diode, the new family of solutions appeared along with the Bursian ones. In the absence of the external magnetic field as well as when it is weak, the potential distribution shows a wavy nature. However, when the Larmor radius was ten times the beam Debye length, the wavy potential profile and non-Bursian branches disappeared. Based on this phenomenon, a non-neutral diode can be used to operate fast electronic switches.

  3. Landsliding in partially saturated materials

    NASA Astrophysics Data System (ADS)

    Godt, Jonathan W.; Baum, Rex L.; Lu, Ning

    2009-01-01

    Rainfall-induced landslides are pervasive in hillslope environments around the world and among the most costly and deadly natural hazards. However, capturing their occurrence with scientific instrumentation in a natural setting is extremely rare. The prevailing thinking on landslide initiation, particularly for those landslides that occur under intense precipitation, is that the failure surface is saturated and has positive pore-water pressures acting on it. Most analytic methods used for landslide hazard assessment are based on the above perception and assume that the failure surface is located beneath a water table. By monitoring the pore water and soil suction response to rainfall, we observed shallow landslide occurrence under partially saturated conditions for the first time in a natural setting. We show that the partially saturated shallow landslide at this site is predictable using measured soil suction and water content and a novel unified effective stress concept for partially saturated earth materials.

  4. Landsliding in partially saturated materials

    USGS Publications Warehouse

    Godt, J.W.; Baum, R.L.; Lu, N.

    2009-01-01

    [1] Rainfall-induced landslides are pervasive in hillslope environments around the world and among the most costly and deadly natural hazards. However, capturing their occurrence with scientific instrumentation in a natural setting is extremely rare. The prevailing thinking on landslide initiation, particularly for those landslides that occur under intense precipitation, is that the failure surface is saturated and has positive pore-water pressures acting on it. Most analytic methods used for landslide hazard assessment are based on the above perception and assume that the failure surface is located beneath a water table. By monitoring the pore water and soil suction response to rainfall, we observed shallow landslide occurrence under partially saturated conditions for the first time in a natural setting. We show that the partially saturated shallow landslide at this site is predictable using measured soil suction and water content and a novel unified effective stress concept for partially saturated earth materials. Copyright 2009 by the American Geophysical Union.

  5. Time features of delayed neutrons and partial emissive-fission cross sections for the neutron-induced fission of {sup 232}Th nuclei in the energy range 3.2-17.9 MeV

    SciTech Connect

    Roshchenko, V. A. Piksaikin, V. M. Korolev, G. G.; Egorov, A. S.

    2010-06-15

    The energy dependence of the relative abundances of delayed neutrons and the energy dependence of the half-lives of their precursors in the neutron-induced fission of {sup 232}Th nuclei in the energy range 3.2-17.9 MeV were measured for the first time. A systematics of the time features of delayed neutrons is developed. This systematics makes it possible to estimate the half-life of delayed-neutron precursors as a function of the nucleonic composition of fissile nuclei by using a single parameter set for all nuclides. The energy dependence of the partial cross sections for emissive fission in the reaction {sup 232}Th(n, f) was analyzed on the basis of data obtained for the relative abundances of delayed neutrons and the aforementioned half-lives and on the basis of the created systematics of the time features of delayed neutrons. It was shown experimentally for the first time that the decrease in the cross section after the reaction threshold in the fission of {sup 232}Th nuclei (it has a pronounced first-chance plateau) is not an exclusion among the already studied uranium, plutonium, and curium isotopes and complies with theoretical predictions obtained for the respective nuclei with allowance for shell, superfluid, and collective effects in the nuclear-level density and with allowance for preequilibrium neutron emission

  6. Partially entangled states bridge in quantum teleportation

    NASA Astrophysics Data System (ADS)

    Cai, Xiao-Fei; Yu, Xu-Tao; Shi, Li-Hui; Zhang, Zai-Chen

    2014-10-01

    The traditional method for information transfer in a quantum communication system using partially entangled state resource is quantum distillation or direct teleportation. In order to reduce the waiting time cost in hop-by-hop transmission and execute independently in each node, we propose a quantum bridging method with partially entangled states to teleport quantum states from source node to destination node. We also prove that the designed specific quantum bridging circuit is feasible for partially entangled states teleportation across multiple intermediate nodes. Compared to two traditional ways, our partially entanglement quantum bridging method uses simpler logic gates, has better security, and can be used in less quantum resource situation.

  7. The partial-birth stratagem.

    PubMed

    1998-06-01

    In Wisconsin, physicians stopped performing abortions when a Federal District Court Judge refused to issue a temporary restraining order against the state's newly enacted "partial birth" abortion ban that was couched in such vague language it actually covered all abortions. While ostensibly attempting to ban late-term "intact dilation and extraction," the language of the law did not refer to that procedure or to late terms. Instead, it prohibited all abortions in which a physician "partially vaginally delivers a living child, causes the death of the partially delivered child with the intent to kill the child and then completes the delivery of the child." The law also defined "child" as "a human being from the time of fertilization" until birth. It is clear that this abortion ban is unconstitutional under Row v. Wade, and this unconstitutionality is compounded by the fact that the law allowed no exception to protect a woman's health, which is required by Roe for abortion bans after fetal viability. Wisconsin is only one of about 28 states that have enacted similar laws, and only two have restricted the ban to postviability abortions. Many of these laws have been struck down in court, and President Clinton has continued to veto the Federal partial-birth bill. The Wisconsin Judge acknowledged that opponents of the ban will likely prevail when the case is heard, but his action in denying the temporary injunction means that many women in Wisconsin will not receive timely medical care. The partial birth strategy is really only another anti-abortion strategy.

  8. Partial coalescence of soap bubbles

    NASA Astrophysics Data System (ADS)

    Harris, Daniel M.; Pucci, Giuseppe; Bush, John W. M.

    2015-11-01

    We present the results of an experimental investigation of the merger of a soap bubble with a planar soap film. When gently deposited onto a horizontal film, a bubble may interact with the underlying film in such a way as to decrease in size, leaving behind a smaller daughter bubble with approximately half the radius of its progenitor. The process repeats up to three times, with each partial coalescence event occurring over a time scale comparable to the inertial-capillary time. Our results are compared to the recent numerical simulations of Martin and Blanchette and to the coalescence cascade of droplets on a fluid bath.

  9. Measurement of Spin-Lattice Relaxation Times and Concentrations in Systems with Chemical Exchange Using the One-Pulse Sequence: Breakdown of the Ernst Model for Partial Saturation in Nuclear Magnetic Resonance Spectroscopy

    NASA Astrophysics Data System (ADS)

    Spencer, Richard G. S.; Fishbein, Kenneth W.

    2000-01-01

    A fundamental problem in Fourier transform NMR spectroscopy is the calculation of observed resonance amplitudes for a repetitively pulsed sample, as first analyzed by Ernst and Anderson in 1966. Applications include determination of spin-lattice relaxation times (T1's) by progressive saturation and correction for partial saturation in order to determine the concentrations of the chemical constituents of a spectrum. Accordingly, the Ernst and Anderson formalism has been used in innumerable studies of chemical and, more recently, physiological systems. However, that formalism implicitly assumes that no chemical exchange occurs. Here, we present an analysis of N sites in an arbitrary chemical exchange network, explicitly focusing on the intermediate exchange rate regime in which the spin-lattice relaxation rates and the chemical exchange rates are comparable in magnitude. As a special case of particular importance, detailed results are provided for a system with three sites undergoing mutual exchange. Specific properties of the N-site network are then detailed. We find that (i) the Ernst and Anderson analysis describing the response of a system to repetitive pulsing is inapplicable to systems with chemical exchange and can result in large errors in T1 and concentration measurements; (ii) T1's for systems with arbitrary exchange networks may still be correctly determined from a one-pulse experiment using the Ernst formula, provided that a short interpulse delay time and a large flip angle are used; (iii) chemical concentrations for exchanging systems may be correctly determined from a one-pulse experiment either by using a short interpulse delay time with a large flip angle, as for measuring T1's, and correcting for partial saturation by use of the Ernst formula, or directly by using a long interpulse delay time to avoid saturation; (iv) there is a significant signal-to-noise penalty for performing one-pulse experiments under conditions which permit accurate

  10. Twisted partially pure spinors

    NASA Astrophysics Data System (ADS)

    Herrera, Rafael; Tellez, Ivan

    2016-08-01

    Motivated by the relationship between orthogonal complex structures and pure spinors, we define twisted partially pure spinors in order to characterize spinorially subspaces of Euclidean space endowed with a complex structure.

  11. Time?

    NASA Astrophysics Data System (ADS)

    Amoroso, Richard L.

    2013-09-01

    The concept of time in the `clockwork' Newtonian world was irrelevant; and has generally been ignored until recently by several generations of physicists since the implementation of quantum mechanics. We will set aside the utility of time as a property relating to physical calculations of events relating to a metrics line element or as an aspect of the transformation of a particles motion/interaction in a coordinate system or in relation to thermodynamics etc., i.e. we will discard all the usual uses of time as a concept used to circularly define physical parameters in terms of other physical parameters; concentrating instead on time as an aspect of the fundamental cosmic topology of our virtual reality especially as it inseparably relates to the nature and role of the observer in natural science.

  12. Honey Bee Venom (Apis mellifera) Contains Anticoagulation Factors and Increases the Blood-clotting Time

    PubMed Central

    Zolfagharian, Hossein; Mohajeri, Mohammad; Babaie, Mahdi

    2015-01-01

    Objectives: Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its effects on blood coagulation and purification. Methods: Crude venom obtained from Apis mellifera was selected. The anti-coagulation factor of the crude venom from this species was purified by using gel filtration chromatography (sephadex G-50), and the molecular weights of the anti-coagulants in this venom estimated by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Blood samples were obtained from 10 rabbits, and the prothrombin time (PT) and the partial thromboplastin time (PTT) tests were conducted. The approximate lethal dose (LD) values of BV were determined. Results: Crude BV increased the blood clotting time. For BV concentrations from 1 to 4 mg/mL, clotting was not observed even at more than 300 seconds, standard deviations (SDs) = ± 0.71; however, clotting was observed in the control group 13.8 s, SDs = ± 0.52. Thus, BV can be considered as containing anti-coagulation factors. Crude BV is composed 4 protein bands with molecular weights of 3, 15, 20 and 41 kilodalton (kDa), respectively. The LD50 of the crude BV was found to be 177.8 μg/mouse. Conclusion: BV contains anti-coagulation factors. The fraction extracted from the Iranian bees contains proteins that are similar to anti-coagulation proteins, such as phospholipase A2 (PLA2) and melittin, and that can increase the blood clotting times in vitro. PMID:26998384

  13. Partial stabilization-based guidance.

    PubMed

    Shafiei, M H; Binazadeh, T

    2012-01-01

    A novel nonlinear missile guidance law against maneuvering targets is designed based on the principles of partial stability. It is demonstrated that in a real approach which is adopted with actual situations, each state of the guidance system must have a special behavior and asymptotic stability or exponential stability of all states is not realistic. Thus, a new guidance law is developed based on the partial stability theorem in such a way that the behaviors of states in the closed-loop system are in conformity with a real guidance scenario that leads to collision. The performance of the proposed guidance law in terms of interception time and control effort is compared with the sliding mode guidance law by means of numerical simulations.

  14. Variance Components: Partialled vs. Common.

    ERIC Educational Resources Information Center

    Curtis, Ervin W.

    1985-01-01

    A new approach to partialling components is used. Like conventional partialling, this approach orthogonalizes variables by partitioning the scores or observations. Unlike conventional partialling, it yields a common component and two unique components. (Author/GDC)

  15. Methanol partial oxidation reformer

    DOEpatents

    Ahmed, S.; Kumar, R.; Krumpelt, M.

    1999-08-17

    A partial oxidation reformer is described comprising a longitudinally extending chamber having a methanol, water and an air inlet and an outlet. An igniter mechanism is near the inlets for igniting a mixture of methanol and air, while a partial oxidation catalyst in the chamber is spaced from the inlets and converts methanol and oxygen to carbon dioxide and hydrogen. Controlling the oxygen to methanol mole ratio provides continuous slightly exothermic partial oxidation reactions of methanol and air producing hydrogen gas. The liquid is preferably injected in droplets having diameters less than 100 micrometers. The reformer is useful in a propulsion system for a vehicle which supplies a hydrogen-containing gas to the negative electrode of a fuel cell. 7 figs.

  16. Methanol partial oxidation reformer

    DOEpatents

    Ahmed, Shabbir; Kumar, Romesh; Krumpelt, Michael

    1999-01-01

    A partial oxidation reformer comprising a longitudinally extending chamber having a methanol, water and an air inlet and an outlet. An igniter mechanism is near the inlets for igniting a mixture of methanol and air, while a partial oxidation catalyst in the chamber is spaced from the inlets and converts methanol and oxygen to carbon dioxide and hydrogen. Controlling the oxygen to methanol mole ratio provides continuous slightly exothermic partial oxidation reactions of methanol and air producing hydrogen gas. The liquid is preferably injected in droplets having diameters less than 100 micrometers. The reformer is useful in a propulsion system for a vehicle which supplies a hydrogen-containing gas to the negative electrode of a fuel cell.

  17. Methanol partial oxidation reformer

    DOEpatents

    Ahmed, Shabbir; Kumar, Romesh; Krumpelt, Michael

    2001-01-01

    A partial oxidation reformer comprising a longitudinally extending chamber having a methanol, water and an air inlet and an outlet. An igniter mechanism is near the inlets for igniting a mixture of methanol and air, while a partial oxidation catalyst in the chamber is spaced from the inlets and converts methanol and oxygen to carbon dioxide and hydrogen. Controlling the oxygen to methanol mole ratio provides continuous slightly exothermic partial oxidation reactions of methanol and air producing hydrogen gas. The liquid is preferably injected in droplets having diameters less than 100 micrometers. The reformer is useful in a propulsion system for a vehicle which supplies a hydrogen-containing gas to the negative electrode of a fuel cell.

  18. Methanol partial oxidation reformer

    DOEpatents

    Ahmed, S.; Kumar, R.; Krumpelt, M.

    1999-08-24

    A partial oxidation reformer is described comprising a longitudinally extending chamber having a methanol, water and an air inlet and an outlet. An igniter mechanism is near the inlets for igniting a mixture of methanol and air, while a partial oxidation catalyst in the chamber is spaced from the inlets and converts methanol and oxygen to carbon dioxide and hydrogen. Controlling the oxygen to methanol mole ratio provides continuous slightly exothermic partial oxidation reactions of methanol and air producing hydrogen gas. The liquid is preferably injected in droplets having diameters less than 100 micrometers. The reformer is useful in a propulsion system for a vehicle which supplies a hydrogen-containing gas to the negative electrode of a fuel cell. 7 figs.

  19. Oxygen partial pressure sensor

    DOEpatents

    Dees, D.W.

    1994-09-06

    A method for detecting oxygen partial pressure and an oxygen partial pressure sensor are provided. The method for measuring oxygen partial pressure includes contacting oxygen to a solid oxide electrolyte and measuring the subsequent change in electrical conductivity of the solid oxide electrolyte. A solid oxide electrolyte is utilized that contacts both a porous electrode and a nonporous electrode. The electrical conductivity of the solid oxide electrolyte is affected when oxygen from an exhaust stream permeates through the porous electrode to establish an equilibrium of oxygen anions in the electrolyte, thereby displacing electrons throughout the electrolyte to form an electron gradient. By adapting the two electrodes to sense a voltage potential between them, the change in electrolyte conductivity due to oxygen presence can be measured. 1 fig.

  20. Oxygen partial pressure sensor

    DOEpatents

    Dees, Dennis W.

    1994-01-01

    A method for detecting oxygen partial pressure and an oxygen partial pressure sensor are provided. The method for measuring oxygen partial pressure includes contacting oxygen to a solid oxide electrolyte and measuring the subsequent change in electrical conductivity of the solid oxide electrolyte. A solid oxide electrolyte is utilized that contacts both a porous electrode and a nonporous electrode. The electrical conductivity of the solid oxide electrolyte is affected when oxygen from an exhaust stream permeates through the porous electrode to establish an equilibrium of oxygen anions in the electrolyte, thereby displacing electrons throughout the electrolyte to form an electron gradient. By adapting the two electrodes to sense a voltage potential between them, the change in electrolyte conductivity due to oxygen presence can be measured.

  1. Dynamics of partial control.

    PubMed

    Sabuco, Juan; Sanjuán, Miguel A F; Yorke, James A

    2012-12-01

    Safe sets are a basic ingredient in the strategy of partial control of chaotic systems. Recently we have found an algorithm, the sculpting algorithm, which allows us to construct them, when they exist. Here we define another type of set, an asymptotic safe set, to which trajectories are attracted asymptotically when the partial control strategy is applied. We apply all these ideas to a specific example of a Duffing oscillator showing the geometry of these sets in phase space. The software for creating all the figures appearing in this paper is available as supplementary material. PMID:23278093

  2. Interference of M-protein on prothrombin time test – case report

    PubMed Central

    Margetić, Sandra; Ćelap, Ivana; Dukić, Lora; Vukasović, Ines; Virović-Jukić, Lucija

    2016-01-01

    The aim of this report was to present a case of interference on prothrombin time (PT) test that directed further laboratory diagnostics and resulted with final detection of monoclonal gammopathy in an 88-year old man. Routine coagulation testing during medical examination at Emergency Department revealed unmeasurable PT (< 7% activity) and activated partial thromboplastin time (aPTT) within reference range. After repeated sampling for coagulation testing, PT was unmeasurable again, as well as fibrinogen level (< 0.8 g/L), thrombin time (TT) was significantly prolonged (107 seconds) and aPTT was within reference range. In both plasma samples refrigerated at 4 ˚C overnight, white gelatinous precipitate was visible between the cell and plasma layers and the presence of monoclonal protein (M-protein) was suggested in our patient. Further laboratory diagnostics revealed total serum proteins at concentration of 123 g/L and the presence of M-protein IgG lambda (λ) at concentration of 47.1 g/L. These results suggested monoclonal gammopathy as an underlying pathophysiological condition in our patient. Activities of coagulation factors II, V, VII and X were within reference ranges or increased. These results and correction of unmeasurable PT result to 67% in mixing test with commercial normal plasma suggest in vitro rather than in vivo interference of M-protein on PT result. In contrast, significantly prolonged TT results in all analysed samples suggest impact of M-protein on this global coagulation test due to possible effect on fibrin polymerization. PMID:27346971

  3. Partial hue-matching.

    PubMed

    Logvinenko, Alexander D; Beattie, Lesley L

    2011-01-01

    It is widely believed that color can be decomposed into a small number of component colors. Particularly, each hue can be described as a combination of a restricted set of component hues. Methods, such as color naming and hue scaling, aim at describing color in terms of the relative amount of the component hues. However, there is no consensus on the nomenclature of component hues. Moreover, the very notion of hue (not to mention component hue) is usually defined verbally rather than perceptually. In this paper, we make an attempt to operationalize such a fundamental attribute of color as hue without the use of verbal terms. Specifically, we put forth a new method--partial hue-matching--that is based on judgments of whether two colors have some hue in common. It allows a set of component hues to be established objectively, without resorting to verbal definitions. Specifically, the largest sets of color stimuli, all of which partially match each other (referred to as chromaticity classes), can be derived from the observer's partial hue-matches. A chromaticity class proves to consist of all color stimuli that contain a particular component hue. Thus, the chromaticity classes fully define the set of component hues. Using samples of Munsell papers, a few experiments on partial hue-matching were carried out with twelve inexperienced normal trichromatic observers. The results reinforce the classical notion of four component hues (yellow, blue, red, and green). Black and white (but not gray) were also found to be component colors. PMID:21742961

  4. Partial knee replacement

    MedlinePlus

    ... You will need to understand what surgery and recovery will be like. Partial knee arthroplasty may be a good choice if you have arthritis in only one side or part of the knee and: You are older, thin, and not very active. You do not ...

  5. Partial coalescence of soap bubbles

    NASA Astrophysics Data System (ADS)

    Pucci, G.; Harris, D. M.; Bush, J. W. M.

    2015-06-01

    We present the results of an experimental investigation of the merger of a soap bubble with a planar soap film. When gently deposited onto a horizontal film, a bubble may interact with the underlying film in such a way as to decrease in size, leaving behind a smaller daughter bubble with approximately half the radius of its progenitor. The process repeats up to three times, with each partial coalescence event occurring over a time scale comparable to the inertial-capillary time. Our results are compared to the recent numerical simulations of Martin and Blanchette ["Simulations of surfactant effects on the dynamics of coalescing drops and bubbles," Phys. Fluids 27, 012103 (2015)] and to the coalescence cascade of droplets on a fluid bath.

  6. Partially integrated exhaust manifold

    SciTech Connect

    Hayman, Alan W; Baker, Rodney E

    2015-01-20

    A partially integrated manifold assembly is disclosed which improves performance, reduces cost and provides efficient packaging of engine components. The partially integrated manifold assembly includes a first leg extending from a first port and terminating at a mounting flange for an exhaust gas control valve. Multiple additional legs (depending on the total number of cylinders) are integrally formed with the cylinder head assembly and extend from the ports of the associated cylinder and terminate at an exit port flange. These additional legs are longer than the first leg such that the exit port flange is spaced apart from the mounting flange. This configuration provides increased packaging space adjacent the first leg for any valving that may be required to control the direction and destination of exhaust flow in recirculation to an EGR valve or downstream to a catalytic converter.

  7. Laparoscopic partial splenic resection.

    PubMed

    Uranüs, S; Pfeifer, J; Schauer, C; Kronberger, L; Rabl, H; Ranftl, G; Hauser, H; Bahadori, K

    1995-04-01

    Twenty domestic pigs with an average weight of 30 kg were subjected to laparoscopic partial splenic resection with the aim of determining the feasibility, reliability, and safety of this procedure. Unlike the human spleen, the pig spleen is perpendicular to the body's long axis, and it is long and slender. The parenchyma was severed through the middle third, where the organ is thickest. An 18-mm trocar with a 60-mm Endopath linear cutter was used for the resection. The tissue was removed with a 33-mm trocar. The operation was successfully concluded in all animals. No capsule tears occurred as a result of applying the stapler. Optimal hemostasis was achieved on the resected edges in all animals. Although these findings cannot be extended to human surgery without reservations, we suggest that diagnostic partial resection and minor cyst resections are ideal initial indications for this minimally invasive approach.

  8. Time-course effects of intravenously administrated silica nanoparticles on blood coagulation and endothelial function in rats.

    PubMed

    Liu, Xin; Sun, Jiao

    2013-01-01

    Among the most used inorganic nanomaterials, silica nanoparticles (NPs) have been considered as either drug carriers or contrast agents. Though the distribution of silica NPs via the circulation appears highly probable, to date, there are few studies investigating the vascular effects of silica NPs in vivo. This study was designed specifically to investigate whether silica NPs with intravenous injection could lead to blood coagulation disorder and endothelium dysfunction in vivo. The time-course effect of silica NPs on blood coagulation, oxidative stress and the expression of soluble E-selectin (sE-selectin) and tissue factor (TF) in the plasma of Sprague Dawley (SD) rats were presented. Our data showed that a shortened prothrombin time (PT) was observed on 1 day after exposure to silica NPs, while activated partial thromboplastin time (APTT) was not affected at any time-points. After the post-injection respectively, the levels of fibrinogen (Fbg) were increased by silica NPs from 1 day to 3 days, and returned to normal value on the 7th day. Meanwhile, a sustained increase in the levels of TF and sE-selectin was elicited by silica NPs during 7 days after the injection. In addition, after 7 days of intravenously injection of silica NPs, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in the plasma of SD rats were decreased significantly, whereas the level of malondialdehyde (MDA) was not changed obviously. In conclusion, intravenously administration of silica NPs could shorten PT but not APTT increase TF and sE-selectin release and reduce GSH-px and SOD activity in the plasma of SD rats, indicating exposure to silica NPs could early activate coagulation cascade via the extrinsic pathway, and may be dependent on endothelium dysfunction and oxidative stress.

  9. Correlation of rocket propulsion fuel properties with chemical composition using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry followed by partial least squares regression analysis.

    PubMed

    Kehimkar, Benjamin; Hoggard, Jamin C; Marney, Luke C; Billingsley, Matthew C; Fraga, Carlos G; Bruno, Thomas J; Synovec, Robert E

    2014-01-31

    There is an increased need to more fully assess and control the composition of kerosene-based rocket propulsion fuels such as RP-1. In particular, it is critical to make better quantitative connections among the following three attributes: fuel performance (thermal stability, sooting propensity, engine specific impulse, etc.), fuel properties (such as flash point, density, kinematic viscosity, net heat of combustion, and hydrogen content), and the chemical composition of a given fuel, i.e., amounts of specific chemical compounds and compound classes present in a fuel as a result of feedstock blending and/or processing. Recent efforts in predicting fuel chemical and physical behavior through modeling put greater emphasis on attaining detailed and accurate fuel properties and fuel composition information. Often, one-dimensional gas chromatography (GC) combined with mass spectrometry (MS) is employed to provide chemical composition information. Building on approaches that used GC-MS, but to glean substantially more chemical information from these complex fuels, we recently studied the use of comprehensive two dimensional (2D) gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOFMS) using a "reversed column" format: RTX-wax column for the first dimension, and a RTX-1 column for the second dimension. In this report, by applying chemometric data analysis, specifically partial least-squares (PLS) regression analysis, we are able to readily model (and correlate) the chemical compositional information provided by use of GC×GC-TOFMS to RP-1 fuel property information such as density, kinematic viscosity, net heat of combustion, and so on. Furthermore, we readily identified compounds that contribute significantly to measured differences in fuel properties based on results from the PLS models. We anticipate this new chemical analysis strategy will have broad implications for the development of high fidelity composition-property models, leading to an

  10. Species-Level Identification of Actinomyces Isolates Causing Invasive Infections: Multiyear Comparison of Vitek MS (Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry) to Partial Sequencing of the 16S rRNA Gene.

    PubMed

    Lynch, T; Gregson, D; Church, D L

    2016-03-01

    Actinomyces species are uncommon but important causes of invasive infections. The ability of our regional clinical microbiology laboratory to report species-level identification of Actinomyces relied on molecular identification by partial sequencing of the 16S ribosomal gene prior to the implementation of the Vitek MS (matrix-assisted laser desorption ionization-time of flight mass spectrometry [MALDI-TOF MS]) system. We compared the use of the Vitek MS to that of 16S rRNA gene sequencing for reliable species-level identification of invasive infections caused by Actinomyces spp. because limited data had been published for this important genera. A total of 115 cases of Actinomyces spp., either alone or as part of a polymicrobial infection, were diagnosed between 2011 and 2014. Actinomyces spp. were considered the principal pathogen in bloodstream infections (n = 17, 15%), in skin and soft tissue abscesses (n = 25, 22%), and in pulmonary (n = 26, 23%), bone (n = 27, 23%), intraabdominal (n = 16, 14%), and central nervous system (n = 4, 3%) infections. Compared to sequencing and identification from the SmartGene Integrated Database Network System (IDNS), Vitek MS identified 47/115 (41%) isolates to the correct species and 10 (9%) isolates to the correct genus. However, the Vitek MS was unable to provide identification for 43 (37%) isolates while 15 (13%) had discordant results. Phylogenetic analyses of the 16S rRNA sequences demonstrate high diversity in recovered Actinomyces spp. and provide additional information to compare/confirm discordant identifications between MALDI-TOF and 16S rRNA gene sequences. This study highlights the diversity of clinically relevant Actinomyces spp. and provides an important typing comparison. Based on our analysis, 16S rRNA gene sequencing should be used to rapidly identify Actinomyces spp. until MALDI-TOF databases are optimized.

  11. Correlation of rocket propulsion fuel properties with chemical composition using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry followed by partial least squares regression analysis.

    PubMed

    Kehimkar, Benjamin; Hoggard, Jamin C; Marney, Luke C; Billingsley, Matthew C; Fraga, Carlos G; Bruno, Thomas J; Synovec, Robert E

    2014-01-31

    There is an increased need to more fully assess and control the composition of kerosene-based rocket propulsion fuels such as RP-1. In particular, it is critical to make better quantitative connections among the following three attributes: fuel performance (thermal stability, sooting propensity, engine specific impulse, etc.), fuel properties (such as flash point, density, kinematic viscosity, net heat of combustion, and hydrogen content), and the chemical composition of a given fuel, i.e., amounts of specific chemical compounds and compound classes present in a fuel as a result of feedstock blending and/or processing. Recent efforts in predicting fuel chemical and physical behavior through modeling put greater emphasis on attaining detailed and accurate fuel properties and fuel composition information. Often, one-dimensional gas chromatography (GC) combined with mass spectrometry (MS) is employed to provide chemical composition information. Building on approaches that used GC-MS, but to glean substantially more chemical information from these complex fuels, we recently studied the use of comprehensive two dimensional (2D) gas chromatography combined with time-of-flight mass spectrometry (GC×GC-TOFMS) using a "reversed column" format: RTX-wax column for the first dimension, and a RTX-1 column for the second dimension. In this report, by applying chemometric data analysis, specifically partial least-squares (PLS) regression analysis, we are able to readily model (and correlate) the chemical compositional information provided by use of GC×GC-TOFMS to RP-1 fuel property information such as density, kinematic viscosity, net heat of combustion, and so on. Furthermore, we readily identified compounds that contribute significantly to measured differences in fuel properties based on results from the PLS models. We anticipate this new chemical analysis strategy will have broad implications for the development of high fidelity composition-property models, leading to an

  12. Studies on the purification of antihemophilic factor (factor VIII). II. Separation of partially purified antihemophilic factor by gel filtration of plasma.

    PubMed

    Ratnoff, O D; Kass, L; Lang, P D

    1969-05-01

    A high degree of purification of antihemophilic factor was achieved by filtration of chylomicronpoor human plasma through columns of agarose. The final product contained, on the average, 67 units of antihemophilic activity per mg of protein, and was 3360-fold purified compared with the filtered plasma. The molecular weight of antihemophilic factor appeared to be at least two million. Preparations separated by gel filtration were contaminated with appreciable amounts of plasma thromboplastin antecedent (PTA), and traces of Christmas factor and Hageman factor, but no detectable fibrinogen was present. Similar fractions of plasma prepared from the blood of patients with classic hemophilia, von Willebrand's disease, or a circulating anticoagulant directed against antihemophilic factor contained, on the average, somewhat less protein than normal plasma; whether this difference was significant is not yet known. The purified fractions were partially stabilized by the addition of 1% gelatin. Adaptation of the technique of gel filtration to purification of antihemophilic factor for clinical use remains to be explored.

  13. Coagulation profile and platelet parameters of the Arabian sand gazelle (Gazella subgutturosa marica): comparison with humans and camels.

    PubMed

    Hussein, M F; Aljumaah, R S; Homeida, A M; Alhaidary, A A; Alshaikh, M A; Gar Elnabi, A; Mohammed, O B; Omer, Sawsan A; Macasero, W V

    2010-10-01

    During March 2009, we evaluated the hemostatic profile and platelet indices of 18 Arabian sand gazelles (Gazella subgutturosa marica) and compared the results with those from humans and camels (Camelus dromedarius). Gazelles and camels had shorter activated partial thromboplastin times, lower proconvertin and higher antihemophilic factor coagulation activity, and plasma fibrinogen levels than humans. Prothrombin time was longer in sand gazelles and shorter in camels than it was in humans. Plasma thromboplastin component, Stuart factor, and plasma thromboplastin antecedent were similar in gazelles, humans, and camels, whereas the platelet count of the sand gazelle was significantly higher than it was for camels and humans. PMID:20966267

  14. Melancholia and partial insanity.

    PubMed

    Jackson, S W

    1983-04-01

    In the medical literature of the eighteenth century melancholia came to be defined as partial insanity. Seventeenth-century English law introduced the term and influenced later forensic concerns about the concept. But the history of melancholia reveals a gradual development of such a concept of limited derangement associated with the delusions usually cited in accounts of this disease. In the early nineteenth century the relationship of melancholia and this concept weakened and was gradually abandoned, the content of the syndrome of melancholia was reduced, and out of this complex process emerged the notion of monomania.

  15. Esthetic removable partial dentures.

    PubMed

    Ancowitz, Stephen

    2004-01-01

    This article provides information regarding the many ways that removable partial dentures (RPDs) may be used to solve restorative problems in the esthetic zone without displaying metal components or conspicuous acrylic resin flanges. The esthetic zone is defined and described, as are methods for recording it. Six dental categories are presented that assist the dentist in choosing a variety of RPD design concepts that may be used to avoid metal display while still satisfying basic principles of RPDs. New materials that may be utilized for optimal esthetics are presented and techniques for contouring acrylic resin bases and tinting denture bases are described.

  16. Robotic partial nephrectomy: current technique and outcomes.

    PubMed

    Wang, Liang; Lee, Benjamin R

    2013-09-01

    Over the past decade, management of the T1 renal mass has focused on nephron-sparing surgery. Robotic partial nephrectomy has played an increasing role in the technique of preserving renal function by decreasing warm ischemia time, as well as optimizing outcomes of hemorrhage and fistula. Robot-assisted partial nephrectomy is designed to provide a minimally-invasive nephron-sparing surgical option utilizing reconstructive capability, decreasing intracorporeal suturing time, technical feasibility and safety. Ultimately, its benefits are resulting in its dissemination across institutions. Articulated instrumentation and three-dimensional vision facilitate resection, collecting system reconstruction and renorrhaphy, leading to decreased warm ischemia time while preserving oncological outcomes. The aim of the present review was to present our surgical sequence and technique, as well as review the current status of robot-assisted partial nephrectomy.

  17. Experts' Understanding of Partial Derivatives Using the Partial Derivative Machine

    ERIC Educational Resources Information Center

    Roundy, David; Weber, Eric; Dray, Tevian; Bajracharya, Rabindra R.; Dorko, Allison; Smith, Emily M.; Manogue, Corinne A.

    2015-01-01

    Partial derivatives are used in a variety of different ways within physics. Thermodynamics, in particular, uses partial derivatives in ways that students often find especially confusing. We are at the beginning of a study of the teaching of partial derivatives, with a goal of better aligning the teaching of multivariable calculus with the needs of…

  18. Is Titan Partially Differentiated?

    NASA Astrophysics Data System (ADS)

    Mitri, G.; Pappalardo, R. T.; Stevenson, D. J.

    2009-12-01

    The recent measurement of the gravity coefficients from the Radio Doppler data of the Cassini spacecraft has improved our knowledge of the interior structure of Titan (Rappaport et al. 2008 AGU, P21A-1343). The measured gravity field of Titan is dominated by near hydrostatic quadrupole components. We have used the measured gravitational coefficients, thermal models and the hydrostatic equilibrium theory to derive Titan's interior structure. The axial moment of inertia gives us an indication of the degree of the interior differentiation. The inferred axial moment of inertia, calculated using the quadrupole gravitational coefficients and the Radau-Darwin approximation, indicates that Titan is partially differentiated. If Titan is partially differentiated then the interior must avoid melting of the ice during its evolution. This suggests a relatively late formation of Titan to avoid the presence of short-lived radioisotopes (Al-26). This also suggests the onset of convection after accretion to efficiently remove the heat from the interior. The outer layer is likely composed mainly of water in solid phase. Thermal modeling indicates that water could be present also in liquid phase forming a subsurface ocean between an outer ice I shell and a high pressure ice layer. Acknowledgments: This work was conducted at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.

  19. Partial Triceps Disruption

    PubMed Central

    Foulk, David M.; Galloway, Marc T.

    2011-01-01

    Partial triceps tendon disruptions are a rare injury that can lead to debilitating outcomes if misdiagnosed or managed inappropriately. The clinician should have a high index of suspicion when the mechanism involves a fall onto an outstretched arm and there is resultant elbow extension weakness along with pain and swelling. The most common location of rupture is at the tendon-osseous junction. This case report illustrates a partial triceps tendon disruption with involvement of, primarily, the medial head and the superficial expansion. Physical examination displayed weakness with resisted elbow extension in a flexed position over 90°. Radiographs revealed a tiny fleck of bone proximal to the olecranon, but this drastically underestimated the extent of injury upon surgical exploration. Magnetic resonance imaging is essential to ascertain the percentage involvement of the tendon; it can be used for patient education and subsequently to determine treatment recommendations. Although excellent at finding associated pathology, it may misjudge the size of the tear. As such, physicians must consider associated comorbidities and patient characteristics when formulating treatment plans. PMID:23016005

  20. Combatting the "partial-birth abortion" myth.

    PubMed

    1998-11-01

    Despite the efforts of pro-choice activists in the US to point out the critical differences between so-called "partial-birth abortions" and late-term abortions, the public remains confused about the issue. Proposed federal legislation banning "partial-birth abortions" excludes any language defining late-term abortions (time period or fetal viability). Thus, such a ban would apply to any abortion at any stage of pregnancy. Only the states of Kansas and Utah have passed legislation that limit the ban to late-term abortions. The term "partial-birth abortion" also has no independent meaning: it is not a medical term nor does it refer to a medical procedure. The correct term, "intact dilation and extraction," is never mentioned in most proposed legislation, much of which is written in broad enough language to outlaw all abortions. Most states that passed bans on "partial-birth abortions," in fact, had previously banned late-term abortions. In Georgia, a court order revised a "partial-birth abortion" law by limiting it to post-viability dilation and extraction and insisting on exceptions to protect the pregnant women's life and health. The courts have severely limited or enjoined "partial-birth abortion" legislation in 19 of the 20 states where challenges were mounted. Because an educated public overwhelmingly rejects the bans, reproductive rights activists are attempting to educate the public despite the inability or unwillingness of the media to make the crucial distinction. PMID:12294330

  1. Combatting the "partial-birth abortion" myth.

    PubMed

    1998-11-01

    Despite the efforts of pro-choice activists in the US to point out the critical differences between so-called "partial-birth abortions" and late-term abortions, the public remains confused about the issue. Proposed federal legislation banning "partial-birth abortions" excludes any language defining late-term abortions (time period or fetal viability). Thus, such a ban would apply to any abortion at any stage of pregnancy. Only the states of Kansas and Utah have passed legislation that limit the ban to late-term abortions. The term "partial-birth abortion" also has no independent meaning: it is not a medical term nor does it refer to a medical procedure. The correct term, "intact dilation and extraction," is never mentioned in most proposed legislation, much of which is written in broad enough language to outlaw all abortions. Most states that passed bans on "partial-birth abortions," in fact, had previously banned late-term abortions. In Georgia, a court order revised a "partial-birth abortion" law by limiting it to post-viability dilation and extraction and insisting on exceptions to protect the pregnant women's life and health. The courts have severely limited or enjoined "partial-birth abortion" legislation in 19 of the 20 states where challenges were mounted. Because an educated public overwhelmingly rejects the bans, reproductive rights activists are attempting to educate the public despite the inability or unwillingness of the media to make the crucial distinction.

  2. Partially segmented deformable mirror

    DOEpatents

    Bliss, E.S.; Smith, J.R.; Salmon, J.T.; Monjes, J.A.

    1991-05-21

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp. 5 figures.

  3. Partially segmented deformable mirror

    DOEpatents

    Bliss, Erlan S.; Smith, James R.; Salmon, J. Thaddeus; Monjes, Julio A.

    1991-01-01

    A partially segmented deformable mirror is formed with a mirror plate having a smooth and continuous front surface and a plurality of actuators to its back surface. The back surface is divided into triangular areas which are mutually separated by grooves. The grooves are deep enough to make the plate deformable and the actuators for displacing the mirror plate in the direction normal to its surface are inserted in the grooves at the vertices of the triangular areas. Each actuator includes a transducer supported by a receptacle with outer shells having outer surfaces. The vertices have inner walls which are approximately perpendicular to the mirror surface and make planar contacts with the outer surfaces of the outer shells. The adhesive which is used on these contact surfaces tends to contract when it dries but the outer shells can bend and serve to minimize the tendency of the mirror to warp.

  4. Partially supervised speaker clustering.

    PubMed

    Tang, Hao; Chu, Stephen Mingyu; Hasegawa-Johnson, Mark; Huang, Thomas S

    2012-05-01

    Content-based multimedia indexing, retrieval, and processing as well as multimedia databases demand the structuring of the media content (image, audio, video, text, etc.), one significant goal being to associate the identity of the content to the individual segments of the signals. In this paper, we specifically address the problem of speaker clustering, the task of assigning every speech utterance in an audio stream to its speaker. We offer a complete treatment to the idea of partially supervised speaker clustering, which refers to the use of our prior knowledge of speakers in general to assist the unsupervised speaker clustering process. By means of an independent training data set, we encode the prior knowledge at the various stages of the speaker clustering pipeline via 1) learning a speaker-discriminative acoustic feature transformation, 2) learning a universal speaker prior model, and 3) learning a discriminative speaker subspace, or equivalently, a speaker-discriminative distance metric. We study the directional scattering property of the Gaussian mixture model (GMM) mean supervector representation of utterances in the high-dimensional space, and advocate exploiting this property by using the cosine distance metric instead of the euclidean distance metric for speaker clustering in the GMM mean supervector space. We propose to perform discriminant analysis based on the cosine distance metric, which leads to a novel distance metric learning algorithm—linear spherical discriminant analysis (LSDA). We show that the proposed LSDA formulation can be systematically solved within the elegant graph embedding general dimensionality reduction framework. Our speaker clustering experiments on the GALE database clearly indicate that 1) our speaker clustering methods based on the GMM mean supervector representation and vector-based distance metrics outperform traditional speaker clustering methods based on the “bag of acoustic features” representation and statistical

  5. On-Chip Titration of an Anticoagulant Argatroban and Determination of the Clotting Time within Whole Blood or Plasma Using a Plug-Based Microfluidic System

    PubMed Central

    Song, Helen; Li, Hung-Wing; Munson, Matthew S.; Van Ha, Thuong G.; Ismagilov, Rustem F.

    2006-01-01

    This paper describes extending plug-based microfluidics to handling complex biological fluids such as blood, solving the problem of injecting additional reagents into plugs, and applying this system to measuring of clotting time in small volumes of whole blood and plasma. Plugs are droplets transported through microchannels by fluorocarbon fluids. A plug-based microfluidic system was developed to titrate an anticoagulant (argatroban) into blood samples and to measure the clotting time using the activated partial thromboplastin time (APTT) test. To carry out these experiments, the following techniques were developed for a plug-based system: (i) using Teflon AF coating on the microchannel wall to enable formation of plugs containing blood and transport of the solid fibrin clots within plugs, (ii) using a hydrophilic glass capillary to enable reliable merging of a reagent from an aqueous stream into plugs, (iii) using bright-field microscopy to detect the formation of a fibrin clot within plugs and using fluorescent microscopy to detect the production of thrombin using a fluorogenic substrate, and (iv) titration of argatroban (0–1.5 μg/mL) into plugs and measurement of the resulting APTTs at room temperature (23 °C) and physiological temperature (37 °C). APTT measurements were conducted with normal pooled plasma (platelet-poor plasma) and with donor’s blood samples (both whole blood and platelet-rich plasma). APTT values and APTT ratios measured by the plug-based microfluidic device were compared to the results from a clinical laboratory at 37 °C. APTT obtained from the on-chip assay were about double those from the clinical laboratory but the APTT ratios from these two methods agreed well with each other. PMID:16841902

  6. Discordance between ROTEM® clotting time and conventional tests during unfractionated heparin-based anticoagulation in intensive care patients on extracorporeal membrane oxygenation.

    PubMed

    Prakash, S; Wiersema, U F; Bihari, S; Roxby, D

    2016-01-01

    We hypothesised that ROTEM® (Basel, Switzerland) INTEM® (ROTEM, Basel, Switzerland) clotting time (CT) would have good agreement with activated partial thromboplastin time (aPTT) in determining whether a dose adjustment should be made to the unfractionated heparin (UFH) infusion in patients on extracorporeal membrane oxygenation. All patients treated with extracorporeal membrane oxygenation over a five-year period were included for data analysis. Retrospective analysis was performed of prospectively collected data points, wherein aPTT, activated CT and ROTEM was performed simultaneously to monitor UFH-based anticoagulation. Two hundred data points were available for analysis. Turnaround time was shortest for activated CT followed by ROTEM and aPTT. Despite achieving therapeutic aPTT targets, the majority (>50%) of INTEM CT results were within normal limits. The aPTT and INTEM CT results correlated weakly (r=0.31, 95% confidence interval [0.17, 0.43]) and there was no agreement between the directional changes of aPTT and INTEM CT results on successive days (x² =2.33, P=0.17). Due to relative insensitivity, INTEM CT-guided UFH titration was estimated to result in a 289% increase in incidence of up-titration, over aPTT-guided titration. The INTEM CT results (r=0.36, 95% confidence interval [0.23, 0.48]) correlated weakly with UFH infusion rates. The UFH infusion rate only explained 13% variability in INTEM CT values. While haemorrhagic complications were frequent, no major clotting complications were encountered. Our results demonstrated that aPTT and INTEM CT do not provide equivalent information to guide UFH infusion rate titration during extracorporeal membrane oxygenation. Our study suggests caution regarding the use of ROTEM for guiding UFH-based anticoagulation as it may lead to excessive UFH exposure. PMID:26673593

  7. Diffraction imaging: The limits of partial coherence

    NASA Astrophysics Data System (ADS)

    Chen, Bo; Abbey, Brian; Dilanian, Ruben; Balaur, Eugeniu; van Riessen, Grant; Junker, Mark; Tran, Chanh Q.; Jones, Michael W. M.; Peele, Andrew G.; McNulty, Ian; Vine, David J.; Putkunz, Corey T.; Quiney, Harry M.; Nugent, Keith A.

    2012-12-01

    Coherent diffraction imaging (CDI) typically requires that the source should be highly coherent both laterally and longitudinally. In this paper, we demonstrate that lateral and longitudinal partial coherence can be successfully included in a CDI reconstruction algorithm simultaneously using experimental x-ray data. We study the interplay between lateral partial coherence and longitudinal partial coherence and their relative influence on CDI. We compare our results against the coherence criteria published by Spence [Spence , UltramicroscopyULTRD60304-399110.1016/j.ultramic.2004.05.005 101, 149 (2004)] and show that for iterative ab initio phase-recovery algorithms based on those typically used in CDI and in cases where the coherence properties are known, we are able to relax the minimal coherence requirements by a factor of 2 both laterally and longitudinally, potentially yielding significant reduction in exposure time.

  8. Trigonometric Integrals via Partial Fractions

    ERIC Educational Resources Information Center

    Chen, H.; Fulford, M.

    2005-01-01

    Parametric differentiation is used to derive the partial fractions decompositions of certain rational functions. Those decompositions enable us to integrate some new combinations of trigonometric functions.

  9. Incremental fusion of partial biometric information

    NASA Astrophysics Data System (ADS)

    Abboud, Ali J.; Jassim, Sabah A.

    2012-06-01

    Existing face recognition schemes are mostly based on extracting biometric feature vectors either from whole face images, or from a fixed facial region (e.g., eyes, nose, and mouth). Extreme variation in quality conditions between biometric enrolment and verification stages badly affects the performance of face recognition systems. Such problems have partly motivated several investigations into the use of partial facial features for face recognition. Nevertheless, partial face recognition is potentially useful in several applications, for instance, it used in forensics for detectives to identify individuals after some accidents such as fire or explosion. In this paper, we propose a scheme to fuse the biometric information of partial face images incrementally based on their recognition accuracy (or discriminative power) ranks. Such fusion scheme uses the optimal ratio of full/partial face images in each different quality condition. We found that such scheme is also useful for full face images to enhance authentication accuracy significantly. Nevertheless, it reduces the required storage requirements and processing time of the biometric system. Our experiments show that the required ratio of full/partial facial images to achieve optimal performance varies from (5%) to (80%) according to the quality conditions whereas the authentication accuracy improves significantly for low quality biometric samples.

  10. Experts' understanding of partial derivatives using the partial derivative machine

    NASA Astrophysics Data System (ADS)

    Roundy, David; Weber, Eric; Dray, Tevian; Bajracharya, Rabindra R.; Dorko, Allison; Smith, Emily M.; Manogue, Corinne A.

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] Partial derivatives are used in a variety of different ways within physics. Thermodynamics, in particular, uses partial derivatives in ways that students often find especially confusing. We are at the beginning of a study of the teaching of partial derivatives, with a goal of better aligning the teaching of multivariable calculus with the needs of students in STEM disciplines. In this paper, we report on an initial study of expert understanding of partial derivatives across three disciplines: physics, engineering, and mathematics. We report on the central research question of how disciplinary experts understand partial derivatives, and how their concept images of partial derivatives differ, with a focus on experimentally measured quantities. Using the partial derivative machine (PDM), we probed expert understanding of partial derivatives in an experimental context without a known functional form. In particular, we investigated which representations were cued by the experts' interactions with the PDM. Whereas the physicists and engineers were quick to use measurements to find a numeric approximation for a derivative, the mathematicians repeatedly returned to speculation as to the functional form; although they were comfortable drawing qualitative conclusions about the system from measurements, they were reluctant to approximate the derivative through measurement. On a theoretical front, we found ways in which existing frameworks for the concept of derivative could be expanded to include numerical approximation.

  11. Regularized Partial and/or Constrained Redundancy Analysis

    ERIC Educational Resources Information Center

    Takane, Yoshio; Jung, Sunho

    2008-01-01

    Methods of incorporating a ridge type of regularization into partial redundancy analysis (PRA), constrained redundancy analysis (CRA), and partial and constrained redundancy analysis (PCRA) were discussed. The usefulness of ridge estimation in reducing mean square error (MSE) has been recognized in multiple regression analysis for some time,…

  12. 20 CFR 10.402 - What is partial disability?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true What is partial disability? 10.402 Section 10... AMENDED Compensation and Related Benefits Compensation for Disability and Impairment § 10.402 What is partial disability? An injured employee who cannot return to the position held at the time of injury...

  13. Ingestion of a Fixed Partial Denture During General Anesthesia

    PubMed Central

    Neustein, Steve; Beicke, Mark

    2007-01-01

    Dental trauma during anesthesia is a common occurrence. Many patients have had extensive dental work, which is more fragile than the natural dentition. This work may include crowns, fixed partial dentures (bridges), and porcelain veneers. We report for the first time, a case in which a fixed partial denture became dislodged and was ingested, and was recovered postoperatively with endoscopy. PMID:17579503

  14. Chiral and continuum extrapolation of partially quenched lattice results

    SciTech Connect

    C.R. Allton; W. Armour; D.B. Leinweber; A.W. Thomas; R.D. Young

    2005-04-01

    The vector meson mass is extracted from a large sample of partially quenched, two-flavor lattice QCD simulations. For the first time, discretization, finite-volume and partial quenching artifacts are treated in a unified chiral effective field theory analysis of the lattice simulation results.

  15. Partial Retirement and Pension Policy in Industrialized Countries.

    ERIC Educational Resources Information Center

    Latulippe, Denis; Turner, John

    2000-01-01

    Examines the advantages and disadvantages of partial retirement--the transitional period between full-time employment and complete retirement--including easing the transition, labor market effects, and financial implications for social security systems and employers. Reviews partial retirement policies in eight countries and concludes that there…

  16. 38 CFR 36.4316 - Acceptability of partial payments.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... (CONTINUED) LOAN GUARANTY Guaranty or Insurance of Loans to Veterans With Electronic Reporting § 36.4316 Acceptability of partial payments. A partial payment is a remittance by or on behalf of the borrower on a loan... the loan and security instruments at the time the remittance is tendered. (a) Except as provided...

  17. Partial confinement photonic crystal waveguides

    SciTech Connect

    Saini, S.; Hong, C.-Y.; Pfaff, N.; Kimerling, L. C.; Michel, J.

    2008-12-29

    One-dimensional photonic crystal waveguides with an incomplete photonic band gap are modeled and proposed for an integration application that exploits their property of partial angular confinement. Planar apodized photonic crystal structures are deposited by plasma enhanced chemical vapor deposition and characterized by reflectivity as a function of angle and polarization, validating a partial confinement design for light at 850 nm wavelength. Partial confinement identifies an approach for tailoring waveguide properties by the exploitation of conformal film deposition over a substrate with angularly dependent topology. An application for an optoelectronic transceiver is demonstrated.

  18. The partially filled viscous ring damper.

    NASA Technical Reports Server (NTRS)

    Alfriend, K. T.

    1973-01-01

    The problem of a spinning satellite with a partially filled viscous ring damper is investigated. It is shown that there are two distinct modes of motion, the nutation-synchronous mode and spin-synchronous mode. From an approximate solution of the equations of motion a time constant is obtained for each mode. From a consideration of the fluid dynamics several methods are developed for determining the damping constant.

  19. Partial Data Traces: Efficient Generation and Representation

    SciTech Connect

    Mueller, F; De Supinski, B R; McKee, S A; Yoo, A

    2001-08-20

    Binary manipulation techniques are increasing in popularity. They support program transformations tailored toward certain program inputs, and these transformations have been shown to yield performance gains beyond the scope of static code optimizations without profile-directed feedback. They even deliver moderate gains in the presence of profile-guided optimizations. In addition, transformations can be performed on the entire executable, including library routines. This work focuses on program instrumentation, yet another application of binary manipulation. This paper reports preliminary results on generating partial data traces through dynamic binary rewriting. The contributions are threefold. First, a portable method for extracting precise data traces for partial executions of arbitrary applications is developed. Second, a set of hierarchical structures for compactly representing these accesses is developed. Third, an efficient online algorithm to detect regular accesses is introduced. The authors utilize dynamic binary rewriting to selectively collect partial address traces of regions within a program. This allows partial tracing of hot paths for only a short time during program execution in contrast to static rewriting techniques that lack hot path detection and also lack facilities to limit the duration of data collection. Preliminary results show reductions of three orders of a magnitude of inline instrumentation over a dual process approach involving context switching. They also report constant size representations for regular access patters in nested loops. These efforts are part of a larger project to counter the increasing gap between processor and main memory speeds by means of software optimization and hardware enhancements.

  20. Partial-Payload Support Structure

    NASA Technical Reports Server (NTRS)

    Mitchell, R.; Freeman, M.

    1984-01-01

    Partial-payload support structure (PPSS) is modular, bridge like structure supporting experiments weighing up to 2 tons. PPSS handles such experiments more economically than standard Spacelab pallet system.

  1. Complex partial status and schizophrenia.

    PubMed

    Ardila, A; Gómez, J

    1988-04-01

    Three cases of complex partial status which were diagnosed as psychotic episodes are presented. The scans of two of these cases show structural abnormalities in the left temporal lobe. It is proposed that there are similar neurophysiological mechanisms in primary schizophrenia and in the perceptual, affective and cognitive phenomena apparent is some complex and psychic partial seizures. The hippocampal-amygdaline system plays a central role in both cases.

  2. [Acrylic resin removable partial dentures].

    PubMed

    de Baat, C; Witter, D J; Creugers, N H J

    2011-01-01

    An acrylic resin removable partial denture is distinguished from other types of removable partial dentures by an all-acrylic resin base which is, in principle, solely supported by the edentulous regions of the tooth arch and in the maxilla also by the hard palate. When compared to the other types of removable partial dentures, the acrylic resin removable partial denture has 3 favourable aspects: the economic aspect, its aesthetic quality and the ease with which it can be extended and adjusted. Disadvantages are an increased risk of caries developing, gingivitis, periodontal disease, denture stomatitis, alveolar bone reduction, tooth migration, triggering of the gag reflex and damage to the acrylic resin base. Present-day indications are ofa temporary or palliative nature or are motivated by economic factors. Special varieties of the acrylic resin removable partial denture are the spoon denture, the flexible denture fabricated of non-rigid acrylic resin, and the two-piece sectional denture. Furthermore, acrylic resin removable partial dentures can be supplied with clasps or reinforced by fibers or metal wires.

  3. [Influence of reagent storage in Sysmex CA7000 for different time on 4 test RESULTS: of the plasma coagulation].

    PubMed

    Chen, Tong-Qing; Li, Zhen-Xing

    2014-12-01

    The purpose of this study was to investigate the influence of blood coagulation reagents stored for different time on test results of the specimens prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (Fib). A total of 21 patient plasma specimens was taken and measured for homeostasis by Sysmex CA7000 automated blood coagulation analyzer and supporting reagent. The PT, APTT, TT and Fib of specimens were measured with the reagents stored in Sysmex CA7000 for different time. The differences of PT, APTT, TT and Fib were analyzed between values measured of the reagents stored for 0 hour and different time (TS:12, 24, 36,48, 60, 72 h; DA:24, 48, 72, 96, 120 h; TT:2, 4, 6, 8, 10, 12 h; TR:4, 8, 12, 16, 20, 24 h; OVB:1, 2, 3, 4, 5 ,6 h), respectively. The results showed that when coagulation reagent TS were stored for more than 48 h , DA 96 h, TT 10 h, TR 16 h and OVB 4 h, the values of PT, APTT, TT and Fib of samples were statistically different from the values measured with fresh coagulation reagent (P < 0.01), respectively. Compared 0 h with TS stored for 48-72, DA 96-120, TT 10-12, TR 16-24 and OVB 4-6 h, the percentage difference of PT, APTT, TT and Fib is in -2.6% ∼ 10.8%, -3.44% ∼ 4.8%, -3.9% ∼ 5.52%, -10.8% ∼ 3.3% and -17.2% ∼ 0.5%, the PT and Fib changes were more significant. Accordingly, the result of PT, APTT and TT had a uptrend as the reagent stored in Sysmex CA7000 analyzer for a long time, while Fib downtrend. It is concluded that the reagents showed be timely replaced when the plasma coagulation test is performed so as to obtain accurate results of examination.

  4. 46 CFR 71.40-1 - General or partial survey.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... partial, according to the circumstances, shall be made every time an accident occurs or a defect is... the material and the workmanship of such repairs or renewals are in all respects satisfactory,...

  5. Identification of cysteinylated transthyretin, a predictive biomarker of treatment response to partially hydrolyzed guar gum in type 2 diabetes rats, by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.

    PubMed

    Naito, Yuji; Ichikawa, Hiroshi; Akagiri, Satomi; Uchiyama, Kazuhiko; Takagi, Tomohisa; Handa, Osamu; Yasukawa, Zenta; Tokunaga, Makoto; Ishihara, Noriyuki; Okubo, Tsutomu; Mukai, Jun; Ohki, Makoto; Uchida, Kagehiro; Yoshikawa, Toshikazu

    2016-01-01

    Recent evidence has indicated that total fiber intake is inversely related to type 2 diabetes risk. The present study aimed to investigate the effects of chronic administration of partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, on the occurrence of diabetes and its complications, fatty liver and nephropathy. We also identified predictive serum biomarkers of treatment response to PHGG by mass spectroscopy-based proteomic analysis using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a good model of human non-insulin-dependent diabetes mellitus. In this study, at 5 weeks of age, OLETF rats and control strain Long-Evans Tokushima Otsuka (LETO) rats were fed a control diet or a high-fiber diet (5% PHGG) for 57 weeks. Body weight, food intake, oral glucose tolerance test, plasma insulin levels, and urine glucose and protein levels were regularly measured. Oral glucose tolerance tests (OGTT) and storage of serum in a deep freezer were conducted at the beginning of the experiment and every 4 weeks after overnight fasting during the experiments. PHGG treatment affected neither meal patterns nor the body weight of OLETF and LETO rats. Repeated measure analysis of variance revealed significant differences in fasting plasma glucose and plasma glucose at 2 h after OGTT between control OLETF (OLETF-C) rats and OLETF rats treated with PHGG (OLETF-F). The glucose response determined by the area under the curve of OGTT was significantly greater in OLETF-C rats than that in OLETF-F rats at 25 weeks of age. HOMA-IR, an index of insulin resistance, increased at 25 weeks of age in OLETF-C rats, while this increase was significantly inhibited in OLETF-F rats. At 62 weeks of age, PHGG treatment significantly improved hepatic steatosis as well as renal mesangial matrix accumulation in OLETF rats. To identify the risk marker for diabetes mellitus by SELDI-TOF MS, we collected sera from 21-week-old individuals. Among the 12 specific peaks that were risk marker

  6. Identification of cysteinylated transthyretin, a predictive biomarker of treatment response to partially hydrolyzed guar gum in type 2 diabetes rats, by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

    PubMed Central

    Naito, Yuji; Ichikawa, Hiroshi; Akagiri, Satomi; Uchiyama, Kazuhiko; Takagi, Tomohisa; Handa, Osamu; Yasukawa, Zenta; Tokunaga, Makoto; Ishihara, Noriyuki; Okubo, Tsutomu; Mukai, Jun; Ohki, Makoto; Uchida, Kagehiro; Yoshikawa, Toshikazu

    2016-01-01

    Recent evidence has indicated that total fiber intake is inversely related to type 2 diabetes risk. The present study aimed to investigate the effects of chronic administration of partially hydrolyzed guar gum (PHGG), a water-soluble dietary fiber, on the occurrence of diabetes and its complications, fatty liver and nephropathy. We also identified predictive serum biomarkers of treatment response to PHGG by mass spectroscopy-based proteomic analysis using Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a good model of human non-insulin-dependent diabetes mellitus. In this study, at 5 weeks of age, OLETF rats and control strain Long-Evans Tokushima Otsuka (LETO) rats were fed a control diet or a high-fiber diet (5% PHGG) for 57 weeks. Body weight, food intake, oral glucose tolerance test, plasma insulin levels, and urine glucose and protein levels were regularly measured. Oral glucose tolerance tests (OGTT) and storage of serum in a deep freezer were conducted at the beginning of the experiment and every 4 weeks after overnight fasting during the experiments. PHGG treatment affected neither meal patterns nor the body weight of OLETF and LETO rats. Repeated measure analysis of variance revealed significant differences in fasting plasma glucose and plasma glucose at 2 h after OGTT between control OLETF (OLETF-C) rats and OLETF rats treated with PHGG (OLETF-F). The glucose response determined by the area under the curve of OGTT was significantly greater in OLETF-C rats than that in OLETF-F rats at 25 weeks of age. HOMA-IR, an index of insulin resistance, increased at 25 weeks of age in OLETF-C rats, while this increase was significantly inhibited in OLETF-F rats. At 62 weeks of age, PHGG treatment significantly improved hepatic steatosis as well as renal mesangial matrix accumulation in OLETF rats. To identify the risk marker for diabetes mellitus by SELDI-TOF MS, we collected sera from 21-week-old individuals. Among the 12 specific peaks that were risk marker

  7. Reasonable partiality in professional relationships.

    PubMed

    Almond, Brenda

    2005-04-01

    First, two aspects of the partiality issue are identified: (1) Is it right/reasonable for professionals to favour their clients' interests over either those of other individuals or those of society in general? (2) Are special non-universalisable obligations attached to certain professional roles? Second, some comments are made on the notions of partiality and reasonableness. On partiality, the assumption that only two positions are possible--a detached universalism or a partialist egoism--is challenged and it is suggested that partiality, e.g. to family members, lies between these two positions, being neither a form of egoism, nor of impersonal detachment. On reasonableness, it is pointed out that 'reasonable' is an ambiguous concept, eliding the notions of the 'morally right' and the 'rational.' Third, a series of practical examples are taken from counselling, medicine, law, education and religious practice and some common principles are abstracted from the cases and discussed. These include truth-telling, confidentiality, conflicts of interest between clients and particular others and between clients and society. It is concluded that while partiality can be justified as a useful tool in standard cases, particular circumstances can affect the final verdict.

  8. Local cerebral metabolism during partial seizures

    SciTech Connect

    Engel, J. Jr.; Kuhl, D.E.; Phelps, M.E.; Rausch, R.; Nuwer, M.

    1983-04-01

    Interictal and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for each patient studied. Focal and generalized increased and decreased metabolism were observed. Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields. Hypometabolism seen on ictal scans most likely reflects postictal depression and may indicate projection fields of inhibited neurons. No quantitative relationship between alterations in metabolism and EEG or behavioral measurements of ictal events could be demonstrated.

  9. Dynamic partial FPGA reconfiguration in space applications

    NASA Astrophysics Data System (ADS)

    Graczyk, Rafal; Stolarski, Marcin; Palau, Marie-Catherine; Orleanski, Piotr

    2012-05-01

    Design and implementation of hardware mock-up of high performance system for general avionics testing in reconfigurable FPGAs. Strong emphasis is put on exploiting dynamic partial reconfiguration capability as a method for functionality multiplexing and fault mitigation. Additionally, dynamic reconfiguration can be used for fault injection which makes Single Event Upset in configuration memory simulation possible. LEON3 processors are used to create an avionic systems test-bed, for testing the mock-ups of real system flight software and testing dynamic full and partial reconfiguration. Experiments with different means of reconfiguration are performed to measure reconfiguration times and stability of software. Several solutions for whole system reconfiguration controller have been implemented and tested.

  10. Apparatus for generating partially coherent radiation

    DOEpatents

    Naulleau, Patrick P.

    2004-09-28

    The effective coherence of an undulator beamline can be tailored to projection lithography requirements by using a simple single moving element and a simple stationary low-cost spherical mirror. The invention is particularly suited for use in an illuminator device for an optical image processing system requiring partially coherent illumination. The illuminator includes: (i) source of coherent or partially coherent radiation which has an intrinsic coherence that is higher than the desired coherence; (ii) a reflective surface that receives incident radiation from said source; (iii) means for moving the reflective surface through a desired range of angles in two dimensions wherein the rate of the motion is fast relative to integration time of said image processing system; and (iv) a condenser optic that re-images the moving reflective surface to the entrance plane of said image processing system, thereby, making the illumination spot in said entrance plane essentially stationary.

  11. Partial pressure analysis of plasmas

    SciTech Connect

    Dylla, H.F.

    1984-11-01

    The application of partial pressure analysis for plasma diagnostic measurements is reviewed. A comparison is made between the techniques of plasma flux analysis and partial pressure analysis for mass spectrometry of plasmas. Emphasis is given to the application of quadrupole mass spectrometers (QMS). The interface problems associated with the coupling of a QMS to a plasma device are discussed including: differential-pumping requirements, electromagnetic interferences from the plasma environment, the detection of surface-active species, ion source interactions, and calibration procedures. Example measurements are presented from process monitoring of glow discharge plasmas which are useful for cleaning and conditioning vacuum vessels.

  12. Full and partial gauge fixing

    SciTech Connect

    Shirzad, A.

    2007-08-15

    Gauge fixing may be done in different ways. We show that using the chain structure to describe a constrained system enables us to use either a full gauge, in which all gauged degrees of freedom are determined, or a partial gauge, in which some first class constraints remain as subsidiary conditions to be imposed on the solutions of the equations of motion. We also show that the number of constants of motion depends on the level in a constraint chain in which the gauge fixing condition is imposed. The relativistic point particle, electromagnetism, and the Polyakov string are discussed as examples and full or partial gauges are distinguished.

  13. Apparatus for generating partially coherent radiation

    DOEpatents

    Naulleau, Patrick P.

    2005-02-22

    Techniques for generating partially coherent radiation and particularly for converting effectively coherent radiation from a synchrotron to partially coherent EUV radiation suitable for projection lithography.

  14. Planarian Immobilization, Partial Irradiation, and Tissue Transplantation

    PubMed Central

    Guedelhoefer IV, Otto C.; Sánchez Alvarado, Alejandro

    2012-01-01

    The planarian, a freshwater flatworm, has proven to be a powerful system for dissecting metazoan regeneration and stem cell biology1,2. Planarian regeneration of any missing or damaged tissues is made possible by adult stem cells termed neoblasts3. Although these stem cells have been definitively shown to be pluripotent and singularly capable of reconstituting an entire animal4, the heterogeneity within the stem cell population and the dynamics of their cellular behaviors remain largely unresolved. Due to the large number and wide distribution of stem cells throughout the planarian body plan, advanced methods for manipulating subpopulations of stem cells for molecular and functional study in vivo are needed. Tissue transplantation and partial irradiation are two methods by which a subpopulation of planarian stem cells can be isolated for further study. Each technique has distinct advantages. Tissue transplantation allows for the introduction of stem cells, into a naïve host, that are either inherently genetically distinct or have been previously treated pharmacologically. Alternatively, partial irradiation allows for the isolation of stem cells within a host, juxtaposed to tissue devoid of stem cells, without the introduction of a wound or any breech in tissue integrity. Using these two methods, one can investigate the cell autonomous and non-autonomous factors that control stem cell functions, such as proliferation, differentiation, and migration. Both tissue transplantation5,6 and partial irradiation7 have been used historically in defining many of the questions about planarian regeneration that remain under study today. However, these techniques have remained underused due to the laborious and inconsistent nature of previous methods. The protocols presented here represent a large step forward in decreasing the time and effort necessary to reproducibly generate large numbers of grafted or partially irradiated animals with efficacies approaching 100 percent. We

  15. Partial comparison of the NxTAG Respiratory Pathogen Panel Assay with the Luminex xTAG Respiratory Panel Fast Assay V2 and singleplex real-time polymerase chain reaction for detection of respiratory pathogens.

    PubMed

    Esposito, Susanna; Scala, Alessia; Bianchini, Sonia; Presicce, Maria Lory; Mori, Alessandro; Sciarrabba, Calogero Sathya; Fior, Giulia; Principi, Nicola

    2016-09-01

    In this study, 185 nasopharyngeal swabs were tested to compare the sensitivity and specificity of the Luminex NxTAG (NxTAG) Respiratory Pathogen Panel (RPP) Assay with those of the Luminex Respiratory Virus Panel (RVP) Fast Assay v2 and singleplex real-time polymerase chain reaction (PCR). The NxTAG Assay identified at least one infectious agent in 164 (88.7%) of the swabs. In 91 (6.2%) tests with negative results with the RVP Fast Assay v2, a virus was identified by the NxTAG (P < 0.001). With the NxTAG Assay, the detection rates were significantly higher for respiratory syncytial virus (P = 0.003), human metapneumovirus (P < 0.001), human rhinovirus/human enterovirus (P = 0.009) and human adenovirus (P < 0.001). Finally, the NxTAG Assay identified M. pneumoniae in 32 of 44 (72.7%) PCR-positive samples. However, the concordance with real-time PCR results was low for both assays. In conclusion, the results indicate that the NxTAG Assay overcomes some of the limitations of previous Luminex assays, although further studies are needed for a more complete evaluation of the new assay.

  16. Partial comparison of the NxTAG Respiratory Pathogen Panel Assay with the Luminex xTAG Respiratory Panel Fast Assay V2 and singleplex real-time polymerase chain reaction for detection of respiratory pathogens.

    PubMed

    Esposito, Susanna; Scala, Alessia; Bianchini, Sonia; Presicce, Maria Lory; Mori, Alessandro; Sciarrabba, Calogero Sathya; Fior, Giulia; Principi, Nicola

    2016-09-01

    In this study, 185 nasopharyngeal swabs were tested to compare the sensitivity and specificity of the Luminex NxTAG (NxTAG) Respiratory Pathogen Panel (RPP) Assay with those of the Luminex Respiratory Virus Panel (RVP) Fast Assay v2 and singleplex real-time polymerase chain reaction (PCR). The NxTAG Assay identified at least one infectious agent in 164 (88.7%) of the swabs. In 91 (6.2%) tests with negative results with the RVP Fast Assay v2, a virus was identified by the NxTAG (P < 0.001). With the NxTAG Assay, the detection rates were significantly higher for respiratory syncytial virus (P = 0.003), human metapneumovirus (P < 0.001), human rhinovirus/human enterovirus (P = 0.009) and human adenovirus (P < 0.001). Finally, the NxTAG Assay identified M. pneumoniae in 32 of 44 (72.7%) PCR-positive samples. However, the concordance with real-time PCR results was low for both assays. In conclusion, the results indicate that the NxTAG Assay overcomes some of the limitations of previous Luminex assays, although further studies are needed for a more complete evaluation of the new assay. PMID:27401400

  17. Partially Opened Oven on Phoenix

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This view from the Robotic Arm Camera on NASA's Phoenix Mars Lander shows partial opening of doors to one of the tiny ovens of the Thermal and Evolved-Gas Analyzer.

    Each oven has a pair of spring-loaded doors. Near the center of the image, the partial opening of a pair of doors reveals screen over the opening where a soil sample will be delivered. The door to the right is fully opened and the one to the left is partially deployed. The doors are 10 centimeters (4 inches) long. The opening is 4 centimeters (1.5 inches) wide.

    Tests on the Phoenix testbed at the University of Arizona, Tucson, indicate that a soil sample could be delivered into the oven through the partially opened doors. Engineers are also exploring possibilities for opening the doors more completely.This image was taken during Phoenix's eighth Martian day, or sol (June 2, 2008).

    The Phoenix Mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development is by Lockheed Martin Space Systems, Denver.

  18. Assessing Partial Knowledge in Vocabulary.

    ERIC Educational Resources Information Center

    Smith, Richard M.

    1987-01-01

    Partial knowledge was assessed in a multiple choice vocabulary test. Test reliability and concurrent validity were compared using Rasch-based dichotomous and polychotomous scoring models. Results supported the polychtomous scoring model, and moderately supported J. O'Connor's theory of vocabulary acquisition. (Author/GDC)

  19. Covert Reinforcement: A Partial Replication.

    ERIC Educational Resources Information Center

    Ripstra, Constance C.; And Others

    A partial replication of an investigation of the effect of covert reinforcement on a perceptual estimation task is described. The study was extended to include an extinction phase. There were five treatment groups: covert reinforcement, neutral scene reinforcement, noncontingent covert reinforcement, and two control groups. Each subject estimated…

  20. Partially molten magma ocean model

    SciTech Connect

    Shirley, D.N.

    1983-02-15

    The properties of the lunar crust and upper mantle can be explained if the outer 300-400 km of the moon was initially only partially molten rather than fully molten. The top of the partially molten region contained about 20% melt and decreased to 0% at 300-400 km depth. Nuclei of anorthositic crust formed over localized bodies of magma segregated from the partial melt, then grew peripherally until they coverd the moon. Throughout most of its growth period the anorthosite crust floated on a layer of magma a few km thick. The thickness of this layer is regulated by the opposing forces of loss of material by fractional crystallization and addition of magma from the partial melt below. Concentrations of Sr, Eu, and Sm in pristine ferroan anorthosites are found to be consistent with this model, as are trends for the ferroan anorthosites and Mg-rich suites on a diagram of An in plagioclase vs. mg in mafics. Clustering of Eu, Sr, and mg values found among pristine ferroan anorthosites are predicted by this model.

  1. Leadership in Partially Distributed Teams

    ERIC Educational Resources Information Center

    Plotnick, Linda

    2009-01-01

    Inter-organizational collaboration is becoming more common. When organizations collaborate they often do so in partially distributed teams (PDTs). A PDT is a hybrid team that has at least one collocated subteam and at least two subteams that are geographically distributed and communicate primarily through electronic media. While PDTs share many…

  2. Model-based approach to partial tracking for musical transcription

    NASA Astrophysics Data System (ADS)

    Sterian, Andrew; Wakefield, Gregory H.

    1998-10-01

    We present a new method for musical partial tracking in the context of musical transcription using a time-frequency Kalman filter structure. The filter is based upon a model for the evolution of a partial behavior across a wide range of pitch from four brass instruments. Statistics are computed independently for the partial attributes of frequency and log-power first differences. We present observed power spectral density shapes, total powers, and histograms, as well as least-squares approximations to these. We demonstrate that a Kalman filter tracker using this partial model is capable of tracking partials in music. We discuss how the filter structure naturally provides quality-of-fit information about the data for use in further processing and how this information can be used to perform partial track initiation and termination within a common framework. We propose that a model-based approach to partial tracking is preferable to existing approaches which generally use heuristic rules or birth/death notions over a small time neighborhood. The advantages include better performance in the presence of cluttered data and simplified tracking over missed observations.

  3. The Painlevé property for partial differential equations

    NASA Astrophysics Data System (ADS)

    Weiss, John; Tabor, M.; Carnevale, George

    1983-03-01

    In this paper we define the Painlevé property for partial differential equations and show how it determines, in a remarkably simple manner, the integrability, the Bäcklund transforms, the linearizing transforms, and the Lax pairs of three well-known partial differential equations (Burgers' equation, KdV equation, and the modified KdV equation). This indicates that the Painlevé property may provide a unified description of integrable behavior in dynamical systems (ordinary and partial differential equations), while, at the same time, providing an efficient method for determining the integrability of particular systems.

  4. Application of partial sliding mode in guidance problem.

    PubMed

    Shafiei, M H; Binazadeh, T

    2013-03-01

    In this paper, the problem of 3-dimensional guidance law design is considered and a new guidance law based on partial sliding mode technique is presented. The approach is based on the classification of the state variables within the guidance system dynamics with respect to their required stabilization properties. In the proposed law by using a partial sliding mode technique, only trajectories of a part of states variables are forced to reach the partial sliding surfaces and slide on them. The resulting guidance law enables the missile to intercept highly maneuvering targets within a finite interception time. Effectiveness of the proposed guidance law is demonstrated through analysis and simulations.

  5. What can we learn from the time course of untreated and partially treated community-onset Streptococcus pneumoniae pneumonia? A clinical perspective on superiority and noninferiority trial designs for mild community-acquired pneumonia.

    PubMed

    File, Thomas M; Schentag, Jerome J

    2008-12-01

    There are no well-designed placebo-controlled clinical trials in the recent era that precisely define the magnitude of the drug effect of antimicrobial therapy for mild community-acquired pneumonia (CAP). However, there is evidence that ineffective therapies, selected on the basis of the ratio of 24-h area under the concentration curve to minimum inhibitory concentration, associated with a discordant (nonsusceptible in vitro) specific agent (or no therapy) for mild CAP due to Streptococcus pneumoniae are associated with increased risk of progression to serious CAP. The relatively high rate of clinical success associated with appropriate antimicrobial treatment of mild CAP renders a standard outcome measure of clinical success an unlikely way to differentiate new agents. However, there may be an advantage in composite outcome assessments for mild CAP. Composite-outcomes end points that include time to resolution of morbidity, the use of patient reported-outcomes instruments, and biomarkers are recommended for future studies. Because the composite rate of success in recent randomized clinical trials exceeds 90%, it would seem that a noninferiority margin of 10% is reasonable for trials for mild CAP.

  6. [Partial lease squares approach to functional analysis].

    PubMed

    Preda, C

    2006-01-01

    We extend the partial least squares (PLS) approach to functional data represented in our models by sample paths of stochastic process with continuous time. Due to the infinite dimension, when functional data are used as a predictor for linear regression and classification models, the estimation problem is an ill-posed one. In this context, PLS offers a simple and efficient alternative to the methods based on the principal components of the stochastic process. We compare the results given by the PLS approach and other linear models using several datasets from economy, industry and medical fields. PMID:17124795

  7. Laparoscopic partial nephrectomy in a horseshoe kidney.

    PubMed

    Molina, Wilson R; Gill, Inderbir S

    2003-12-01

    A 68-year-old man with an incidentally found 2-cm complex enhancing cystic right renal mass in the right moiety of a horseshoe kidney was treated with a three-port retroperitoneal laparoscopic approach. The tumor was completely excised with cold Endoshears, and Surgicel bolsters were tightly buttressed into the resection bed with 0 Vicryl sutures. The warm ischemia time was 31 minutes. To our knowledge, this is the initial case of retroperitoneal laparoscopic partial nephrectomy in a horseshoe kidney. Three-dimensional CT with volume rendering in a video format provides the necessary information about the number, location, and extrarenal anatomy of the renal artery and vein.

  8. Correlation of rocket propulsion fuel properties with chemical composition using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry followed by partial least squares regression analysis

    SciTech Connect

    Kehimkar, Benjamin; Hoggard, Jamin C.; Marney, Luke C.; Billingsley, Matthew; Fraga, Carlos G.; Bruno, Thomas J.; Synovec, Robert E.

    2014-01-31

    There is an increased need to more fully assess and control the composition of kerosene based rocket propulsion fuels, namely RP-1 and RP-2. In particular, it is crucial to be able to make better quantitative connections between the following three attributes: (a) fuel performance, (b) fuel properties (flash point, density, kinematic viscosity, net heat of combustion, hydrogen content, etc) and (c) the chemical composition of a given fuel (i.e., specific chemical compounds and compound classes present as a result of feedstock blending and processing). Indeed, recent efforts in predicting fuel performance through modeling put greater emphasis on detailed and accurate fuel properties and fuel compositional information. In this regard, advanced distillation curve (ADC) metrology provides improved data relative to classical boiling point and volatility curve techniques. Using ADC metrology, data obtained from RP-1 and RP-2 fuels provides compositional variation information that is directly relevant to predictive modeling of fuel performance. Often, in such studies, one-dimensional gas chromatography (GC) combined with mass spectrometry (MS) is typically employed to provide chemical composition information. Building on approaches using GC-MS, but to glean substantially more chemical composition information from these complex fuels, we have recently studied the use of comprehensive two dimensional gas chromatography combined with time-of-flight mass spectrometry (GC × GC - TOFMS) to provide chemical composition data that is significantly richer than that provided by GC-MS methods. In this report, by applying multivariate data analysis techniques, referred to as chemometrics, we are able to readily model (correlate) the chemical compositional information from RP-1 and RP-2 fuels provided using GC × GC - TOFMS, to the fuel property information such as that provided by the ADC method and other specification properties. We anticipate that this new chemical analysis

  9. An Ultrasonic Clamp for Bloodless Partial Nephrectomy

    NASA Astrophysics Data System (ADS)

    Lafon, Cyril; Bouchoux, Guillaume; Murat, François Joseph; Birer, Alain; Theillère, Yves; Chapelon, Jean Yves; Cathignol, Dominique

    2007-05-01

    Maximum conservation of the kidney is preferable through partial nephrectomy for patients at risk of disease recurrence of renal cancers. Haemostatic tools are needed in order to achieve bloodless surgery and reduce post surgery morbidity. Two piezo-ceramic transducers operating at a frequency of 4 MHz were mounted on each arm of a clamp. When used for coagulation purposes, two transducers situated on opposite arms of the clamp were driven simultaneously. Heat delivery was optimized as each transducers mirrored back to targeted tissues the wave generated by the opposite transducer. Real-time treatment monitoring with an echo-based technique was also envisaged with this clamp. Therapy was periodically interrupted so one transducer could generate a pulse. The echo returning from the opposite transducer was treated. Coagulation necroses were obtained in vitro on substantial thicknesses (23-38mm) of pig liver over exposure durations ranging from 30s to 130s, and with acoustic intensities of less than 15W/cm2 per transducer. Both kidneys of two pigs were treated in vivo with the clamp (14.5W/cm2 for 90s), and the partial nephrectomies performed proved to be bloodless. In vitro and in vivo, wide transfixing lesions corresponded to an echo energy decrease superior to -10dB and parabolic form of the time of flight versus treatment time. In conclusion, this ultrasound clamp has proven to be an excellent mean for achieving monitored haemostasis in kidney.

  10. Extrapolation methods for dynamic partial differential equations

    NASA Technical Reports Server (NTRS)

    Turkel, E.

    1978-01-01

    Several extrapolation procedures are presented for increasing the order of accuracy in time for evolutionary partial differential equations. These formulas are based on finite difference schemes in both the spatial and temporal directions. On practical grounds the methods are restricted to schemes that are fourth order in time and either second, fourth or sixth order in space. For hyperbolic problems the second order in space methods are not useful while the fourth order methods offer no advantage over the Kreiss-Oliger method unless very fine meshes are used. Advantages are first achieved using sixth order methods in space coupled with fourth order accuracy in time. Computational results are presented confirming the analytic discussions.

  11. Wettability of partially suspended graphene

    PubMed Central

    Ondarçuhu, Thierry; Thomas, Vincent; Nuñez, Marc; Dujardin, Erik; Rahman, Atikur; Black, Charles T.; Checco, Antonio

    2016-01-01

    The dependence of the wettability of graphene on the nature of the underlying substrate remains only partially understood. Here, we systematically investigate the role of liquid-substrate interactions on the wettability of graphene by varying the area fraction of suspended graphene from 0 to 95% by means of nanotextured substrates. We find that completely suspended graphene exhibits the highest water contact angle (85° ± 5°) compared to partially suspended or supported graphene, regardless of the hydrophobicity (hydrophilicity) of the substrate. Further, 80% of the long-range water-substrate interactions are screened by the graphene monolayer, the wettability of which is primarily determined by short-range graphene-liquid interactions. By its well-defined chemical and geometrical properties, supported graphene therefore provides a model system to elucidate the relative contribution of short and long range interactions to the macroscopic contact angle. PMID:27072195

  12. Wettability of partially suspended graphene

    DOE PAGES

    Ondarçuhu, Thierry; Thomas, Vincent; Nuñez, Marc; Dujardin, Erik; Rahman, Atikur; Black, Charles T.; Checco, Antonio

    2016-04-13

    Dependence on the wettability of graphene on the nature of the underlying substrate remains only partially understood. We systematically investigate the role of liquid-substrate interactions on the wettability of graphene by varying the area fraction of suspended graphene from 0 to 95% by means of nanotextured substrates. We find that completely suspended graphene exhibits the highest water contact angle (85° ± 5°) compared to partially suspended or supported graphene, regardless of the hydrophobicity (hydrophilicity) of the substrate. Moreover, 80% of the long-range water-substrate interactions are screened by the graphene monolayer, the wettability of which is primarily determined by short-range graphene-liquidmore » interactions. By its well-defined chemical and geometrical properties, supported graphene therefore provides a model system to elucidate the relative contribution of short and long range interactions to the macroscopic contact angle.« less

  13. The partial fission of fast spinning asteroids

    NASA Astrophysics Data System (ADS)

    Tardivel, Simon; Sanchez, Paul; Scheeres, Daniel J.

    2016-10-01

    The spin rates of asteroids systematically change over time due the Yarkovsky–O'Keefe–Radzievskii–Paddack (YORP) effect. Above a certain spin rate that depends on the body's density, regions of an asteroid can enter in tension, with components held to the body by cohesive forces. When the body fails, deformation or fission can occur. Catastrophic fission leading to complete disruption has been directly observed in active asteroid P/2013 R3. Partial fission, the loss of only part of the body, has been proposed as a mechanism for the formation of binaries and is explored here.The equatorial cavities of (341843) 2008 EV5 and of (185851) 2000 DP107 (a binary system) are consistent with a localized partial fission of the body (LPSC 2016 #1036). The examination of the gravity field of these bodies reveals that a mass placed within these cavities could be shed. In this mechanism, the outward pull of inertial forces creates an average stress at the cavity interface of ≈1 Pa for 2008 EV5 and ≈3 Pa for 2000 DP107 at spin periods of ≈3.15 h for the assumed densities of 1.3 g/cm3.This work continues the study of this partial, localized fission. Specifically, it addresses the issue of the low cohesion necessary to the mechanism. These cohesion values are typically lower than global strength values inferred on other asteroids (10 - 200 Pa), meaning that partial fission may occur prior to larger-scale deformations. Yet, several processes can explain the discrepancy, as they can naturally segregate particles by size. For instance, landslides or granular convection (Brazil nut effect) could bring larger boulders to the equator of the body, while finer particles are left at higher latitudes or sink to the center. Conversely, failure of the interior could bring boulders to the surface. The peculiar profile shape of these asteroids, shared by many binaries (e.g. 1999 KW4, 1996 FG3) may also be a clue of this heterogeneity, as this "spin top" shape is obtained in

  14. Preparation of partially decaffeinated instant green tea.

    PubMed

    Ye, Jian-Hui; Liang, Yue-Rong; Jin, Jing; Liang, Hue-Ling; Du, Ying-Ying; Lu, Jian-Liang; Ye, Qian; Lin, Chen

    2007-05-01

    The caffeine level of instant tea extracted from decaffeinated leaf tea with 4.0 mg g-1 caffeine is commonly above 10.0 mg g-1, the maximum limit of caffeine for decaffeinated instant tea. Further removal of caffeine by active carbon (AC) from the green tea extract was investigated. It showed that the removal of caffeine from the tea extract solutions depended on the treatment time and tea extract concentration while the ethanol concentration and pH had little effect on the removal of caffeine. According to the removal of caffeine and the ratio of total catechins to caffeine in the tested samples, the optimum decaffeination conditions were determined to be as follows: tea extract concentration 15-30 g L-1 for common tea extract but higher for partially decaffeinated tea leaf extract; ratio of tea solution to AC, 100 mL:4 g; treatment time, 4 h; and natural tea extract pH. Instant tea powder extracted from partially decaffeinated leaf tea with a caffeine level of 4.03 mg g-1 and further decaffeinated by AC had a caffeine level of 7.81 mg g-1, which was 31% lower than that without AC treatment.

  15. Preparation of partially decaffeinated instant green tea.

    PubMed

    Ye, Jian-Hui; Liang, Yue-Rong; Jin, Jing; Liang, Hue-Ling; Du, Ying-Ying; Lu, Jian-Liang; Ye, Qian; Lin, Chen

    2007-05-01

    The caffeine level of instant tea extracted from decaffeinated leaf tea with 4.0 mg g-1 caffeine is commonly above 10.0 mg g-1, the maximum limit of caffeine for decaffeinated instant tea. Further removal of caffeine by active carbon (AC) from the green tea extract was investigated. It showed that the removal of caffeine from the tea extract solutions depended on the treatment time and tea extract concentration while the ethanol concentration and pH had little effect on the removal of caffeine. According to the removal of caffeine and the ratio of total catechins to caffeine in the tested samples, the optimum decaffeination conditions were determined to be as follows: tea extract concentration 15-30 g L-1 for common tea extract but higher for partially decaffeinated tea leaf extract; ratio of tea solution to AC, 100 mL:4 g; treatment time, 4 h; and natural tea extract pH. Instant tea powder extracted from partially decaffeinated leaf tea with a caffeine level of 4.03 mg g-1 and further decaffeinated by AC had a caffeine level of 7.81 mg g-1, which was 31% lower than that without AC treatment. PMID:17407319

  16. A novel prothrombin time assay for assessing the anticoagulant activity of oral factor Xa inhibitors.

    PubMed

    Barrett, Yu Chen; Wang, Zhaoqing; Knabb, Robert M

    2013-09-01

    Conventional prothrombin time (PT) assays have limited sensitivity and dynamic range in monitoring the anticoagulant activity of direct factor Xa inhibitors. Hence, new assays are needed. We modified a PT assay by adding calcium chloride (CaCl2) to the thromboplastin reagent to increase assay dynamic range and improve sensitivity. Effects of calcium and sodium ion concentrations, and sample handling, were evaluated to optimize assay performance. Increasing concentrations of calcium ions produced progressive increases in PT across the factor Xa inhibitor concentrations of 0 to 2500 nmol/L for razaxaban and apixaban. The greatest effect was seen when the thromboplastin reagent was diluted 1:2.25 with 100 mmol/L CaCl2 (thus selected for routine use). The optimized assay showed an interassay precision of 1.5 to 9.3 percentage coefficient of variation (%CV) for razaxaban and 3.1 to 4.6 %CV for apixaban. We conclude that the modified PT assay is likely to be suitable as a pharmacodynamic marker for activity at therapeutic concentrations of factor Xa inhibitors.

  17. Pricing of Claims in Discrete Time with Partial Information

    SciTech Connect

    Rognlien Dahl, Kristina

    2013-10-15

    We consider the pricing problem of a seller with delayed price information. By using Lagrange duality, a dual problem is derived, and it is proved that there is no duality gap. This gives a characterization of the seller's price of a contingent claim. Finally, we analyze the dual problem, and compare the prices offered by two sellers with delayed and full information respectively.

  18. Semantic–Syntactic Partial Word Knowledge Growth Through Reading

    PubMed Central

    Hill, Margaret S.; Petroski, Gregory F.

    2015-01-01

    Purpose Incidental reading provides a powerful opportunity for partial word knowledge growth in the school-age years. The extent to which children of differing language abilities can use reading experiences to glean partial knowledge of words is not well understood. The purpose of this study was to compare semantic–syntactic partial word knowledge growth of children with higher language skills (HL group; overall language standard scores of 85 or higher) to that of children with relatively lower language skills (LL group; overall receptive or expressive standard score below 85). Method Thirty-two children, 16 per group, silently read stories containing unfamiliar nouns and verbs 3 times over a 1-week period. Semantic–syntactic partial word knowledge growth was assessed after each reading and 2–3 days later to assess retention. Results Over time, both groups showed significant partial word knowledge growth, with the HL group showing significantly more growth. In addition, both groups retained knowledge several days later. Conclusion Regardless of language skill level, children benefit from multiple exposures to unfamiliar words in reading in their development and retention of semantic–syntactic partial word knowledge growth. PMID:25409978

  19. Numerical method for computing flow through partially saturated porous media

    SciTech Connect

    Eaton, R.R.

    1983-01-01

    This paper discusses the development of the finite element computer code SAGUARO which calculates the two-dimensional flow of mass and energy through porous media. The media may be saturated or partially saturated. SAGUARO solves the parabolic time-dependent mass transport equation which accounts for the presence of partially saturated zones through the use of highly non-linear material characteristic curves. The energy equation accounts for the possibility of partially-saturated regions by adjusting the thermal capacitances and thermal conductivities according to the volume fraction of water present in the local pores. The code capabilities are demonstrated through the presentation of a sample problem involving the one-dimensional calculation of simultaneous energy transfer and water infiltration into partially saturated hard rock.

  20. Numerical method for computing flow through partially saturated porous media

    NASA Astrophysics Data System (ADS)

    Eaton, R. R.

    This paper discusses the development of the finite element computer code SAGUARO which calculates the two-dimensional flow of mass and energy through porous media. The media may be saturated or partially saturated. SAGUARO solves the parabolic time-dependent mass transport equation which accounts for the presence of partially saturated zones through the use of highly non-linear material characteristic curves. The energy equation accounts for the possibility of partially-saturated regions by adjusting the thermal capacitances and thermal conductivities according to the volume fraction of water present in the local pores. The code capabilities are demonstrated through the presentation of a sample problem involving the one dimensional calculation of simultaneous energy transfer and water infiltration into partially saturated hard rock.

  1. Optimality of partial adiabatic search and its circuit model

    NASA Astrophysics Data System (ADS)

    Mei, Ying; Sun, Jie; Lu, Songfeng; Gao, Chao

    2014-08-01

    In this paper, we first uncover a fact that a partial adiabatic quantum search with time complexity is in fact optimal, in which is the total number of elements in an unstructured database, and () of them are the marked ones(one) . We then discuss how to implement a partial adiabatic search algorithm on the quantum circuit model. From the implementing procedure on the circuit model, we can find out that the approximating steps needed are always in the same order of the time complexity of the adiabatic algorithm.

  2. Laparoscopic partial nephrectomy and wedge resection.

    PubMed

    Kozlowski, P M; Winfield, H N

    2000-12-01

    Partial nephrectomy is a more challenging operation than radical or simple nephrectomy, primarily because of the risk of complications such as bleeding. This problem is even more troublesome with minimally invasive approaches because of the dearth of effective hemostatic instruments and supplies. The location of the lesion determines whether a transperitoneal or a retroperitoneal route will be employed. Centrally located or anterior renal lesions generally are approached transperitoneally whereas peripheral lateral or posterior lesions are accessed by retroperitoneoscopy. The Harmonic Scalpel with slow cutting and high coagulation settings is useful for incising the renal capsule and parenchyma. The argon beam coagulator is helpful to stop any persistent bleeding. The few reported series of laparoscopic partial nephrectomy indicate considerably longer operative times than are needed for open surgery and hospitalization of upwards of 5 days, largely to monitor drainage and urine leakage. It is hoped that this advanced laparoscopic technique will become more user friendly with further developments in techniques and instrumentation to provide patients with the expected benefits of minimally invasive surgery.

  3. A NUCLEAR MEMBRANE CHANGE AFTER PARTIAL HEPATECTOMY

    PubMed Central

    Kishimoto, Susumu; Lieberman, Irving

    1964-01-01

    Partial hepatectomy (67 per cent extirpation) of the rat leads to a change in the membrane of liver nuclei (purified with citric acid) detectable as an increase in electrophoretic mobility. No change is detectable 2 hours after the operation, but between 2 and 6 hours about a 1.4-fold increase in mobility occurs after which the mobility becomes constant at the elevated level. Removal of only 10 per cent of the liver causes no detectable change in 6 hours. Bilateral adrenalectomy immediately before partial hepatectomy does not affect the development of the nuclear change. Actinomycin D and p-fluorophenylalanine, but not noradrenalin, ionizing radiation, or EDTA, suppress the increase in electrophoretic mobility. The level of actinomycin D required to block the nuclear membrane change is 6 times greater than that necessary to prevent the rate increase in hepatic RNA metabolism that follows removal of part of the liver. This discrepancy and the difference in the response to noradrenalin indicate that, at least initially, the nuclear membrane change and the change in the rate of RNA synthesis are independent processes. The inability of EDTA to block the nuclear membrane change shows that the Zn++ requirement for DNA replication is not related to the events that lead to the alteration in the electrokinetic properties of liver nuclei. PMID:14245434

  4. Partial pressure analysis in space testing

    NASA Technical Reports Server (NTRS)

    Tilford, Charles R.

    1994-01-01

    For vacuum-system or test-article analysis it is often desirable to know the species and partial pressures of the vacuum gases. Residual gas or Partial Pressure Analyzers (PPA's) are commonly used for this purpose. These are mass spectrometer-type instruments, most commonly employing quadrupole filters. These instruments can be extremely useful, but they should be used with caution. Depending on the instrument design, calibration procedures, and conditions of use, measurements made with these instruments can be accurate to within a few percent, or in error by two or more orders of magnitude. Significant sources of error can include relative gas sensitivities that differ from handbook values by an order of magnitude, changes in sensitivity with pressure by as much as two orders of magnitude, changes in sensitivity with time after exposure to chemically active gases, and the dependence of the sensitivity for one gas on the pressures of other gases. However, for most instruments, these errors can be greatly reduced with proper operating procedures and conditions of use. In this paper, data are presented illustrating performance characteristics for different instruments and gases, operating parameters are recommended to minimize some errors, and calibrations procedures are described that can detect and/or correct other errors.

  5. Partial Return Yoke for MICE

    SciTech Connect

    Witte H.; Plate, S

    2013-05-03

    The international Muon Ionization Cooling Experiment (MICE) is a large scale experiment which is presently assembled at the Rutherford Appleton Laboratory in Didcot, UK. The purpose of MICE is to demonstrate the concept of ionization cooling experimentally. Ionization cooling is an important accelerator concept which will be essential for future HEP experiments such as a potential Muon Collider or a Neutrino Factory. The MICE experiment will house up to 18 superconducting solenoids, all of which produce a substantial amount of magnetic flux. Recently it was realized that this magnetic flux leads to a considerable stray magnetic field in the MICE hall. This is a concern as technical equipment in the MICE hall may may be compromised by this. In July 2012 a concept called partial return yoke was presented to the MICE community, which reduces the stray field in the MICE hall to a safe level. This report summarizes the general concept, engineering considerations and the expected shielding performance.

  6. Compatibility and Conjugacy on Partial Arrays

    PubMed Central

    Sasikala, K.

    2016-01-01

    Research in combinatorics on words goes back a century. Berstel and Boasson introduced the partial words in the context of gene comparison. Alignment of two genes can be viewed as a construction of two partial words that are said to be compatible. In this paper, we examine to which extent the fundamental properties of partial words such as compatbility and conjugacy remain true for partial arrays. This paper studies a relaxation of the compatibility relation called k-compability. It also studies k-conjugacy of partial arrays. PMID:27774111

  7. Algorithm refinement for stochastic partial differential equations.

    SciTech Connect

    Alexander, F. J.; Garcia, Alejandro L.,; Tartakovsky, D. M.

    2001-01-01

    A hybrid particle/continuum algorithm is formulated for Fickian diffusion in the fluctuating hydrodynamic limit. The particles are taken as independent random walkers; the fluctuating diffusion equation is solved by finite differences with deterministic and white-noise fluxes. At the interface between the particle and continuum computations the coupling is by flux matching, giving exact mass conservation. This methodology is an extension of Adaptive Mesh and Algorithm Refinement to stochastic partial differential equations. A variety of numerical experiments were performed for both steady and time-dependent scenarios. In all cases the mean and variance of density are captured correctly by the stochastic hybrid algorithm. For a non-stochastic version (i.e., using only deterministic continuum fluxes) the mean density is correct, but the variance is reduced except within the particle region, far from the interface. Extensions of the methodology to fluid mechanics applications are discussed.

  8. Solving Partial Differential Equations on Overlapping Grids

    SciTech Connect

    Henshaw, W D

    2008-09-22

    We discuss the solution of partial differential equations (PDEs) on overlapping grids. This is a powerful technique for efficiently solving problems in complex, possibly moving, geometry. An overlapping grid consists of a set of structured grids that overlap and cover the computational domain. By allowing the grids to overlap, grids for complex geometries can be more easily constructed. The overlapping grid approach can also be used to remove coordinate singularities by, for example, covering a sphere with two or more patches. We describe the application of the overlapping grid approach to a variety of different problems. These include the solution of incompressible fluid flows with moving and deforming geometry, the solution of high-speed compressible reactive flow with rigid bodies using adaptive mesh refinement (AMR), and the solution of the time-domain Maxwell's equations of electromagnetism.

  9. Therapeutic concordance of two portable monitors and two routine automatic oral anticoagulant monitoring systems using as reference the manual prothrombin time technique.

    PubMed

    Vacas, Marta; Lafuente, Pedro José; Unanue, Iciar; Santos, Mónica; Iriarte, Jose Antonio

    2003-01-01

    Two models of capillary blood prothrombin time (PT) monitoring systems were evaluated for analytical performance and then compared with two routine PT systems using the reference manual technique and a high-sensitivity thromboplastin. Two sets of 60 and 80 plasmas were analyzed from anticoagulated patients stabilized over 3 months in an INR range 2-3.5 for therapy. Capillary PT determination was performed in two portable monitors, CoaguChek S and CoaguChek PT (Roche Diagnostics), and plasma automatic methods were Neoplastine/STA (Diagnostics Stago) and PT-FibrinogenHsPlus/ACL7000 (Instrumental Laboratories). Thromboplastin Bilbao (TBi), an in-house high-sensitivity rabbit thromboplastin (ISI=1.08), recommended as the reference reagent by an External Spanish Oral Anticoagulant Quality Assessment, was used in the PT manual technique. The two monitors' coefficients of correlation with the reference system were 0.74 for CoaguChek S and 0.81 for CoaguChek PT. The automatic routine systems showed a correlation of 0.92 (Neoplastine/STA) and 0.91 (PT-FbHsPlus/ACL7000). Clinical agreement expressed as the percentage of simple correlation ranged between 75.0% (CoaguChek S) and 88.9% (Neoplastine/STA). The systems having the best kappa index with the manual technique were CoaguChek PT (71.9%) and the Neoplastine/STA system (73%). The routine PT management systems exhibited better correlation and percentage of concordance when using the TBi/manual technique than did the portable monitors, which moreover performed unequally in this regard.

  10. 48 CFR 49.112-1 - Partial payments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... partial payments on settlement proposals before settlement, a prime contractor may request them on the form prescribed in 49.602-4 at any time after submission of interim or final settlement proposals. The... application through the prime contractor which shall attach its own invoice and recommendations to...

  11. Energy conservation by partial recirculation of peanut drying air

    SciTech Connect

    Young, J.H.

    1983-06-01

    Conventional, recirculating, and intermittent type peanut dryers were compared in a three-year study. Comparisons indicate that partial recirculation of peanut drying air may reduce energy consumption per unit of water removed by approximately 25% while also reducing required drying time and maintaining high quality.

  12. A comparison of two sodium citrate concentrations in two evacuated blood collection systems for prothrombin time and ISI determination.

    PubMed

    van den Besselaar, A M; Chantarangkul, V; Tripodi, A

    2000-10-01

    The prothrombin time is usually measured in citrated plasma. The W.H.O. recommended concentration of sodium citrate for blood collection for laboratory control of oral anticoagulant therapy is 0.109 M. Some evacuated blood collection systems include 0.105 M sodium citrate. The purpose of the present study was to establish the difference in ISI calibration between 0.109 and 0.105 M citrate, using 7 types of thromboplastin and various types of instrumentation. The two citrate concentrations were provided in both evacuated siliconised glass tubes and in evacuated polyethylene terephtalate (PET) tubes. The ISI difference between the two citrate concentrations was 5.4% for one system but not greater than 3% for all other systems when blood samples were collected with either siliconized glass or PET tubes. Most of the ISI differences between the two citrate concentrations were not significant at the 5% level. It is concluded that the ISI differences between 0.105 M and 0.109 M citrate are not of practical importance. In contrast, ISI differences between siliconised glass and PET tubes, using either 0.105 or 0.109 M citrate, were significant (p <0.05) for most thromboplastin systems and amounted to 7%. ISI interchange between these glass and PET tubes could induce INR differences amounting to 14%, which could affect clinical dosage of oral anticoagulants. PMID:11057867

  13. Intersexual partial diploids of phycomyces.

    PubMed Central

    Mehta, B J; Cerdá-Olmedo, E

    2001-01-01

    Sexual interaction between strains of opposite sex in many fungi of the order Mucorales modifies hyphal morphology and increases the carotene content. The progeny of crosses of Phycomyces blakesleeanus usually include a small proportion of anomalous segregants that show these signs of sexual stimulation without a partner. We have analyzed the genetic constitution of such segregants from crosses that involved a carF mutation for overaccumulation of beta-carotene and other markers. The new strains were diploids or partial diploids heterozygous for the sex markers. Diploidy was unknown in this fungus and in the Zygomycetes. Random chromosome losses during the vegetative growth of the diploid led to heterokaryosis in the coenocytic mycelia and eventually to sectors of various tints and mating behavior. The changes in the nuclear composition of the mycelia could be followed by selecting for individual nuclei. The results impose a reinterpretation of the sexual cycle of Phycomyces. Some of the intersexual strains that carried the carF mutation contained 25 mg beta-carotene per gram of dry mass and were sufficiently stable for practical use in carotene production. PMID:11404328

  14. GLSMs for partial flag manifolds

    NASA Astrophysics Data System (ADS)

    Donagi, Ron; Sharpe, Eric

    2008-12-01

    In this paper we outline some aspects of nonabelian gauged linear sigma models. First, we review how partial flag manifolds (generalizing Grassmannians) are described physically by nonabelian gauged linear sigma models, paying attention to realizations of tangent bundles and other aspects pertinent to (0, 2) models. Second, we review constructions of Calabi-Yau complete intersections within such flag manifolds, and properties of the gauged linear sigma models. We discuss a number of examples of nonabelian GLSMs in which the Kähler phases are not birational, and in which at least one phase is realized in some fashion other than as a complete intersection, extending previous work of Hori-Tong. We also review an example of an abelian GLSM exhibiting the same phenomenon. We tentatively identify the mathematical relationship between such non-birational phases, as examples of Kuznetsov's homological projective duality. Finally, we discuss linear sigma model moduli spaces in these gauged linear sigma models. We argue that the moduli spaces being realized physically by these GLSMs are precisely Quot and hyperquot schemes, as one would expect mathematically.

  15. Area estimation using multiyear designs and partial crop identification

    NASA Technical Reports Server (NTRS)

    Sielken, R. L., Jr.

    1984-01-01

    Statistical procedures were developed for large area assessments using both satellite and conventional data. Crop acreages, other ground cover indices, and measures of change were the principal characteristics of interest. These characteristics are capable of being estimated from samples collected possibly from several sources at varying times, with different levels of identification. Multiyear analysis techniques were extended to include partially identified samples; the best current year sampling design corresponding to a given sampling history was determined; weights reflecting the precision or confidence in each observation were identified and utilized, and the variation in estimates incorporating partially identified samples were quantified.

  16. Malignant histiocytosis in a cat.

    PubMed

    Court, E A; Earnest-Koons, K A; Barr, S C; Gould, W J

    1993-11-01

    A 13-year-old male domestic shorthair cat was found to have normocytic hypochromic regenerative anemia, lymphopenia, eosinopenia, thrombocytopenia, hyperglycemia, hyperbilirubinemia, and a prolonged activated partial thromboplastin time. Transfusions of packed RBC failed to maintain the PCV above 13% for > 8 hours. The cat was euthanatized. At necropsy, the spleen liver, lymph nodes, and bone marrow were infiltrated with malignant histiocytes undergoing erythrophagocytosis.

  17. 20% PARTIAL SIBERIAN SNAKE IN THE AGS.

    SciTech Connect

    Huang, H; Bai, M; Brown, K A; Glenn, W; Luccio, A U; Mackay, W W; Montag, C; Ptitsyn, V; Roser, T; Tsoupas, N; Zeno, K; Ranjbar, V; Spinka, H; Underwood, D

    2002-11-06

    An 11.4% partial Siberian snake was used to successfully accelerate polarized proton through a strong intrinsic depolarizing spin resonance in the AGS. No noticeable depolarization was observed. This opens up the possibility of using a 20% to 30% partial Siberian snake in the AGS to overcome all weak and strong depolarizing spin resonances. Some design and operation issues of the new partial Siberian snake are discussed.

  18. Quantum states with strong positive partial transpose

    SciTech Connect

    Chruscinski, Dariusz; Jurkowski, Jacek; Kossakowski, Andrzej

    2008-02-15

    We construct a large class of bipartite M x N quantum states which defines a proper subset of states with positive partial transposes (PPTs). Any state from this class has PPT but the positivity of its partial transposition is recognized with respect to canonical factorization of the original density operator. We propose to call elements from this class states with strong positive partial transposes (SPPTs). We conjecture that all SPPT states are separable.

  19. Formalism for Hypercomplex Multidimensional NMR Employing Partial-Component Subsampling

    PubMed Central

    Schuyler, Adam D; Maciejewski, Mark W; Stern, Alan S; Hoch, Jeffrey C

    2012-01-01

    Multidimensional NMR spectroscopy typically employs phase-sensitive detection, which results in hypercomplex data (and spectra) when utilized in more than one dimension. Nonuniform sampling approaches have become commonplace in multidimensional NMR, enabling dramatic reductions in experiment time, increases in sensitivity and/or increases in resolution. In order to utilize nonuniform sampling optimally, it is necessary to characterize the relationship between the spectrum of a uniformly sampled data set and the spectrum of a subsampled data set. In this work we construct an algebra of hypercomplex numbers suitable for representing multidimensional NMR data along with partial-component nonuniform sampling (i.e. the hypercomplex components of data points are subsampled). This formalism leads to a modified DFT–convolution relationship involving a partial-component, hypercomplex point-spread function set. The framework presented here is essential for the continued development and appropriate characterization of partial-component nonuniform sampling. PMID:23246651

  20. Modified soft tissue cast for fixed partial denture: a technique

    PubMed Central

    2011-01-01

    In process of fabrication of a fixed partial denture, dies are trimmed to expose margins of the preparations. The need for the soft tissue cast is quite evident as the soft tissue emergence profile that surrounds the prepared tooth is destroyed in the process of fabrication. This article describes a modified technique to fabricate the soft tissue cast for the conventional fixed partial denture. The impression made with the polyvinylsiloxane was first poured to prepare the die cast. After retrieval of the cast, the same impression was poured second time with the resin based resilient material to cover the facial and proximal gingival areas. The remaining portion of the impression was poured with the gypsum material. This technique does not require additional clinical appointment, second impression procedure, technique sensitive manipulations with impression, or cumbersome laboratory procedures. The simplicity of this technique facilitates and justifies its routine use in fabrication of the fixed partial denture. PMID:21503191

  1. Partial ages: diagnosing transport processes by means of multiple clocks

    NASA Astrophysics Data System (ADS)

    Mouchet, Anne; Cornaton, Fabien; Deleersnijder, Éric; Delhez, Éric J. M.

    2016-03-01

    The concept of age is widely used to quantify the transport rate of tracers - or pollutants - in the environment. The age focuses only on the time taken to reach a given location and disregards other aspects of the path followed by the tracer parcel. To keep track of the subregions visited by the tracer parcel along this path, partial ages are defined as the time spent in the different subregions. Partial ages can be computed in an Eulerian framework in much the same way as the usual age by extending the Constituent oriented Age and Residence Time theory (CART, www.climate.be/CARTpartial ages, applications to a 1D model with lateral/transient storage, to the 1D advection-diffusion equation and to the diagnosis of the ventilation of the deep ocean are provided. They demonstrate the versatility of the concept of partial age and the potential new insights that can be gained with it.

  2. Partial squeeze film levitation modulates fingertip friction.

    PubMed

    Wiertlewski, Michaël; Fenton Friesen, Rebecca; Colgate, J Edward

    2016-08-16

    When touched, a glass plate excited with ultrasonic transverse waves feels notably more slippery than it does at rest. To study this phenomenon, we use frustrated total internal reflection to image the asperities of the skin that are in intimate contact with a glass plate. We observed that the load at the interface is shared between the elastic compression of the asperities of the skin and a squeeze film of air. Stroboscopic investigation reveals that the time evolution of the interfacial gap is partially out of phase with the plate vibration. Taken together, these results suggest that the skin bounces against the vibrating plate but that the bounces are cushioned by a squeeze film of air that does not have time to escape the interfacial separation. This behavior results in dynamic levitation, in which the average number of asperities in intimate contact is reduced, thereby reducing friction. This improved understanding of the physics of friction reduction provides key guidelines for designing interfaces that can dynamically modulate friction with soft materials and biological tissues, such as human fingertips. PMID:27482117

  3. Distinguishing between direct and indirect directional couplings in large oscillator networks: Partial or non-partial phase analyses?

    NASA Astrophysics Data System (ADS)

    Rings, Thorsten; Lehnertz, Klaus

    2016-09-01

    We investigate the relative merit of phase-based methods for inferring directional couplings in complex networks of weakly interacting dynamical systems from multivariate time-series data. We compare the evolution map approach and its partialized extension to each other with respect to their ability to correctly infer the network topology in the presence of indirect directional couplings for various simulated experimental situations using coupled model systems. In addition, we investigate whether the partialized approach allows for additional or complementary indications of directional interactions in evolving epileptic brain networks using intracranial electroencephalographic recordings from an epilepsy patient. For such networks, both direct and indirect directional couplings can be expected, given the brain's connection structure and effects that may arise from limitations inherent to the recording technique. Our findings indicate that particularly in larger networks (number of nodes ≫10 ), the partialized approach does not provide information about directional couplings extending the information gained with the evolution map approach.

  4. [The insula in partial epilepsy].

    PubMed

    Isnard, J; Mauguière, F

    2005-01-01

    The role of the insular lobe in temporal lobe epilepsy (TLE) has often been suggested but never directly demonstrated. In this article, we review data from recent literature and from our stereo-electroencephalographic (SEEG) recordings in patients referred for temporal lobe epilepsy surgery (TLE). Our description of the clinical features of insular lobe seizures is based on data from video and SEEG ictal recordings and direct electric cortical stimulation in a population of 50 consecutive patients whose seizures, on the basis of scalp video EEG recordings, were suspected to originate from, or to rapidly propagate to, the peri-sylvian cortex. A total of 144 intra-insular electrodes have been implanted in this series of patients. In six patients a stereotyped sequence of ictal symptoms could be identified on the basis of electro-clinical correlations. The clinical presentation of insular lobe seizures was that of simple partial seizures occurring in full consciousness, beginning with a sensation of laryngeal constriction followed by paresthesiae that were often unpleasant affecting large cutaneous territories. These initial symptoms were eventually followed by dysarthric speech and/or elementary auditory hallucinations, and seizures often ended with focal dystonic postures. The insular origin of these symptoms was supported by the data from functional cortical mapping of the insula using direct cortical stimulations. We were able to reproduce several of the spontaneous ictal symptoms in the six patients with insular seizures. Moreover, from the whole set of insular stimulations that we performed it could be concluded that the insular cortex is involved in somatic, vegetative and visceral functions to which spontaneous ictal insular symptoms are related. The observation of the insular symptoms sequence at the onset of seizures in patients who are candidates for TLE surgery strongly suggests that the epileptic focus is located in the insular lobe. It entails the risk

  5. Spectral theorem and partial symmetries

    SciTech Connect

    Gozdz, A.; Gozdz, M.

    2012-10-15

    A novel method of the decompositon of a quantum system's Hamiltonian is presented. In this approach the criterion of the decomposition is determined by the symmetries possessed by the sub-Hamiltonians. This procedure is rather generic and independent of the actual global symmetry, or the lack of it, of the full Hamilton operator. A detailed investigation of the time evolution of the various sub-Hamiltonians, therefore the change in time of the symmetry of the physical object, is presented for the case of a vibrator-plus-rotor model. Analytical results are illustrated by direct numerical calculations.

  6. Flood frequency analyses with annual and partial flood series

    NASA Astrophysics Data System (ADS)

    Bezak, N.; Brilly, M.; Sraj, M.

    2012-04-01

    The objective of the study was (1) to analyse the influence of time scale of the data on the results, (2) to analyse the relations between discharge, volume and time of flood waves of the Sava river at Litija (Slovenia), (3) to perform flood frequency analyses of peak discharges with annual and partial data series and compare the results and (4) to explore the influence of threshold value by POT method. Calculations and analyses were made for the period 1953-2010. Daily scale data sets (considering also local maximum) were used. The flood frequency analyses were based on anual and partial data series. The differences between daily and hourly time scale data sets were explored. Daily and hourly time scale hydrographs were compared and differences were analysed. Differences were adequately small. Daily time series with included maximums were logical choice because of the length of the daily time series and because hourly time series were not continuous due to gauging equipment failures. Important objective of the study was to analyse the relationship between discharge, volume and duration of flood waves. Baseflow was separated from continuous daily discharge measurements on simple and complex hydrographs. Simple graphical method with three points was used. Many different coefficients like base flow index were calculated and different combinations of correlation coefficient of wave components were examined. Annual maximum series were used to study the relationship between wave components. Flood frequency analyses were made with annual maximum series and partial duration series. Log-normal distribution, Pearson distribution type 3, log-Pearson distribution type 3, Gumbel distribution, exponential distribution, GEV distribution and GL distribution were used for annual maximum series. Simple equation of linear transformation was used to determine the design discharge and procedure which is proposed in Flood Estimation Handbook was used with GEV and GL distribution

  7. Saline intrusion in partially mixed estuaries

    NASA Astrophysics Data System (ADS)

    Prandle, D.

    2004-03-01

    Restricting interest to partially mixed estuaries, earlier studies of tidally averaged linearised theories relating to the vertical structure of salinity and velocities (accompanying saline intrusion) are extended to take account of tidal straining and associated convective overturning. The applicability of these theories is evaluated by reference to a 'single-point' numerical model in which the time-varying cycle of depth-averaged tidal current amplitude, Û, and a (temporally and vertically) constant saline gradient, S x, are specified. This model highlights the importance of convective overturning in counteracting unstable density structures introduced by tidal straining. By omitting overturning in the model, results agree closely with linearised theoretical derivations. However, incorporating overturning substantially increases tidally averaged surface-to-bed differences for both residual currents, δ u, and salinity, δ s. The vertical structure of tidal currents is a maximum, and hence the effect of tidal straining, in shallow macro-tidal estuaries. The propagation of tidal elevations and currents remains insensitive to saline intrusion in partially mixed estuaries. The applicability of the model was evaluated by simulation of recent measurements by Rippeth et al. (J. Phys. Oceanogr. 31 (2001) 2458). To explore the generality of estuarine responses, the model was run for a wide range of values of saline intrusion lengths, L, and water depths, D. Additional sensitivity analyses were made for changes in Û and bed stress coefficient, k. Response frameworks are shown for: δ u, δ s, potential energy anomaly φ, work done by bed friction and internal shear, rates and efficiency of saline mixing and ratios of relative mixing by diffusion to overturning. By equating the rate of mixing associated with vertical diffusion with river flow, Q, an expression for saline intrusion length L∝D 2/k ÛU o ( Uo river flow velocity) was derived. This formulation agrees with

  8. [Laparoscopic partial nephrectomy: technique and outcomes].

    PubMed

    Colombo, J R; Gill, I S

    2006-05-01

    The indication of laparoscopic partial nephrectomy (LPN) has evolved considerably, and the technique is approaching established status at our institution. Over the past 5 years, the senior author has performed more than 450 laparoscopic partial nephrectomies at the Cleveland Clinic. Herein we present our current technique, review contemporary data and oncological outcomes of LPN.

  9. 49 CFR 234.106 - Partial activation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND... Grade Crossings § 234.106 Partial activation. Upon receipt of a credible report of a partial activation... to warn highway users and railroad employees at the subject crossing in the same manner as...

  10. 49 CFR 234.106 - Partial activation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND... Grade Crossings § 234.106 Partial activation. Upon receipt of a credible report of a partial activation... to warn highway users and railroad employees at the subject crossing in the same manner as...

  11. 49 CFR 234.106 - Partial activation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF TRANSPORTATION GRADE CROSSING SAFETY, INCLUDING SIGNAL SYSTEMS, STATE ACTION PLANS, AND... Grade Crossings § 234.106 Partial activation. Upon receipt of a credible report of a partial activation... to warn highway users and railroad employees at the subject crossing in the same manner as...

  12. 47 CFR 5.69 - Partial grants.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Partial grants. 5.69 Section 5.69...) Applications and Licenses § 5.69 Partial grants. In cases in which the Commission grants an application in part... interference that may result to a station if designated application or applications are subsequently...

  13. Evaluating Models for Partially Clustered Designs

    ERIC Educational Resources Information Center

    Baldwin, Scott A.; Bauer, Daniel J.; Stice, Eric; Rohde, Paul

    2011-01-01

    Partially clustered designs, where clustering occurs in some conditions and not others, are common in psychology, particularly in prevention and intervention trials. This article reports results from a simulation comparing 5 approaches to analyzing partially clustered data, including Type I errors, parameter bias, efficiency, and power. Results…

  14. Exploring Partial Order of European Countries

    ERIC Educational Resources Information Center

    Annoni, Paola; Bruggemann, Rainer

    2009-01-01

    Partial Order Theory has been recently more and more employed in applied science to overcome the intrinsic disadvantage hidden in aggregation, if a multiple attribute system is available. Despite its numerous positive features, there are many practical cases where the interpretation of the partial order can be rather troublesome. In these cases…

  15. RNA search with decision trees and partial covariance models.

    PubMed

    Smith, Jennifer A

    2009-01-01

    The use of partial covariance models to search for RNA family members in genomic sequence databases is explored. The partial models are formed from contiguous subranges of the overall RNA family multiple alignment columns. A binary decision-tree framework is presented for choosing the order to apply the partial models and the score thresholds on which to make the decisions. The decision trees are chosen to minimize computation time subject to the constraint that all of the training sequences are passed to the full covariance model for final evaluation. Computational intelligence methods are suggested to select the decision tree since the tree can be quite complex and there is no obvious method to build the tree in these cases. Experimental results from seven RNA families shows execution times of 0.066-0.268 relative to using the full covariance model alone. Tests on the full sets of known sequences for each family show that at least 95 percent of these sequences are found for two families and 100 percent for five others. Since the full covariance model is run on all sequences accepted by the partial model decision tree, the false alarm rate is at least as low as that of the full model alone.

  16. Catalytic partial oxidation of pyrolysis oils

    NASA Astrophysics Data System (ADS)

    Rennard, David Carl

    2009-12-01

    This thesis explores the catalytic partial oxidation (CPO) of pyrolysis oils to syngas and chemicals. First, an exploration of model compounds and their chemistries under CPO conditions is considered. Then CPO experiments of raw pyrolysis oils are detailed. Finally, plans for future development in this field are discussed. In Chapter 2, organic acids such as propionic acid and lactic acid are oxidized to syngas over Pt catalysts. Equilibrium production of syngas can be achieved over Rh-Ce catalysts; alternatively mechanistic evidence is derived using Pt catalysts in a fuel rich mixture. These experiments show that organic acids, present in pyrolysis oils up to 25%, can undergo CPO to syngas or for the production of chemicals. As the fossil fuels industry also provides organic chemicals such as monomers for plastics, the possibility of deriving such species from pyrolysis oils allows for a greater application of the CPO of biomass. However, chemical production is highly dependent on the originating molecular species. As bio oil comprises up to 400 chemicals, it is essential to understand how difficult it would be to develop a pure product stream. Chapter 3 continues the experimentation from Chapter 2, exploring the CPO of another organic functionality: the ester group. These experiments demonstrate that equilibrium syngas production is possible for esters as well as acids in autothermal operation with contact times as low as tau = 10 ms over Rh-based catalysts. Conversion for these experiments and those with organic acids is >98%, demonstrating the high reactivity of oxygenated compounds on noble metal catalysts. Under CPO conditions, esters decompose in a predictable manner: over Pt and with high fuel to oxygen, non-equilibrium products show a similarity to those from related acids. A mechanism is proposed in which ethyl esters thermally decompose to ethylene and an acid, which decarbonylates homogeneously, driven by heat produced at the catalyst surface. Chapter 4

  17. Partially Observed Mixtures of IRT Models: An Extension of the Generalized Partial-Credit Model

    ERIC Educational Resources Information Center

    Von Davier, Matthias; Yamamoto, Kentaro

    2004-01-01

    The generalized partial-credit model (GPCM) is used frequently in educational testing and in large-scale assessments for analyzing polytomous data. Special cases of the generalized partial-credit model are the partial-credit model--or Rasch model for ordinal data--and the two parameter logistic (2PL) model. This article extends the GPCM to the…

  18. The Development of Perceptual Completion Abilities: Infants' Perception of Stationary, Partially Occluded Objects.

    ERIC Educational Resources Information Center

    Craton, Lincoln G.

    1996-01-01

    In three studies of infants' ability to perceive partially occluded objects with specific appearances, a screen alternately uncovered and covered either a connected or interrupted rectangle. Pattern of infants' looking times suggests that they perceive the unity of the partially occluded object by 6.5 months but did not perceive the form of the…

  19. Precise Point Positioning with Partial Ambiguity Fixing

    PubMed Central

    Li, Pan; Zhang, Xiaohong

    2015-01-01

    Reliable and rapid ambiguity resolution (AR) is the key to fast precise point positioning (PPP). We propose a modified partial ambiguity resolution (PAR) method, in which an elevation and standard deviation criterion are first used to remove the low-precision ambiguity estimates for AR. Subsequently the success rate and ratio-test are simultaneously used in an iterative process to increase the possibility of finding a subset of decorrelated ambiguities which can be fixed with high confidence. One can apply the proposed PAR method to try to achieve an ambiguity-fixed solution when full ambiguity resolution (FAR) fails. We validate this method using data from 450 stations during DOY 021 to 027, 2012. Results demonstrate the proposed PAR method can significantly shorten the time to first fix (TTFF) and increase the fixing rate. Compared with FAR, the average TTFF for PAR is reduced by 14.9% for static PPP and 15.1% for kinematic PPP. Besides, using the PAR method, the average fixing rate can be increased from 83.5% to 98.2% for static PPP, from 80.1% to 95.2% for kinematic PPP respectively. Kinematic PPP accuracy with PAR can also be significantly improved, compared to that with FAR, due to a higher fixing rate. PMID:26067196

  20. Partial volume simulation in software breast phantoms

    NASA Astrophysics Data System (ADS)

    Chen, Feiyu; Pokrajac, David; Shi, Xiquan; Liu, Fengshan; Maidment, Andrew D. A.; Bakic, Predrag R.

    2012-03-01

    A modification to our previous simulation of breast anatomy is proposed, in order to improve the quality of simulated projections generated using software breast phantoms. Anthropomorphic software breast phantoms have been used for quantitative validation of breast imaging systems. Previously, we developed a novel algorithm for breast anatomy simulation, which did not account for the partial volume (PV) of various tissues in a voxel; instead, each phantom voxel was assumed to contain single tissue type. As a result, phantom projection images displayed notable artifacts near the borders between regions of different materials, particularly at the skin-air boundary. These artifacts diminished the realism of phantom images. One solution is to simulate smaller voxels. Reducing voxel size, however, extends the phantom generation time and increases memory requirements. We achieved an improvement in image quality without reducing voxel size by the simulation of PV in voxels containing more than one simulated tissue type. The linear x-ray attenuation coefficient of each voxel is calculated by combining attenuation coefficients proportional to the voxel subvolumes occupied by the various tissues. A local planar approximation of the boundary surface is employed, and the skin volume in each voxel is computed by decomposition into simple geometric shapes. An efficient encoding scheme is proposed for the type and proportion of simulated tissues in each voxel. We illustrate the proposed methodology on phantom slices and simulated mammographic projections. Our results show that the PV simulation has improved image quality by reducing quantization artifacts.

  1. Modification of integrated partial payload lifting assembly

    NASA Technical Reports Server (NTRS)

    Groah, Melodie; Haddock, Michael; Woodworth, Warren

    1986-01-01

    The Integrated Partial Payload Lifting Assembly (IPPLA) is currently used to transport and load experimental payloads into the cargo bay of the Space Shuttle. It is unable to carry the astronaut/passenger tunnel without a structural modification. The purpose of this design is to create a removalbe modification that will allow the IPPLA to lift and carry the passenger tunnel. Modifications evaluated were full-length insert beams which would extend through the existing strongback arms. These beam proposals were eliminated because of high cost and weight. Other proposals evaluated were attachments of cantilever beams to the existing strongback areas. The cantilever proposals reduced cost and weight compared to the full-length modifications. A third method evaluated was to simply make modifications to one side of the IPPLA therefore reducing the materials of the cantilever proposals by 40 percent. The design of the modification selected was completed with two channel beams jointly welded to a centered steel plate. The extension arm modification is inserted into the existing strongback channel beams and bolted into place. Two extension arms are added to one side of the IPPLA to provide the extra length needed to accommodate the passenger tunnel. The center counterbalance will then be offset about 20 inches to center gravity and therefore maintain horizontal status. The extension arm modification was selected because of minimum cost, low weight, and minimal installation time.

  2. Characterization of partially coherent ultrashort XUV pulses

    NASA Astrophysics Data System (ADS)

    Bourassin-Bouchet, Charles; Couprie, Marie-Emmanuelle

    2015-05-01

    Modern ultrafast metrology relies on the postulate that the pulse to be measured is fully coherent, i.e. that it can be completely described by its spectrum and spectral phase. However, synthesizing fully coherent pulses is not always possible in practice, especially in the domain of emerging ultrashort X-ray sources where temporal metrology is strongly needed. As an example, the lack of longitudinal coherence, that is shot-to-shot fluctuations, of Free-Electron Lasers (FEL) has prevented so far their full amplitude and phase temporal characterization. To sort out this issue, we have adapted Frequency-Resolved Optical Gating (FROG), the first and one of the most widespread techniques for pulse characterization, to enable the measurement of partially coherent XUV pulses even down to the attosecond timescale. Especially, this technique allows one to overcome the sources of decoherence that normally prevent a pulse measurement, such as the spectrometer resolution or the presence of XUV/laser arrival time jitter.

  3. Partial nephrectomy: an option in calculus disease?

    PubMed

    Timoney, A G; Payne, S R; Walmsley, B H; Vinnicombe, J; Abercrombie, G F

    1988-12-01

    Thirty-seven patients treated by partial nephrectomy for calculus disease between 1971 and 1986 were reviewed retrospectively. Of the 25 patients available for analysis, 20% developed immediate surgical complications, 20% had residual post-operative stone and 33% developed true ipsilateral stone recurrence during the period of follow-up. Our results from partial nephrectomy for calculus disease are compared with the results of treatment by percutaneous nephrolithotomy and extracorporeal shockwave lithotripsy. It was concluded that partial nephrectomy should be reserved for situations where stone disease is associated with anatomical abnormalities which cannot be treated by the newer modalities of stone management.

  4. Method for partially coating laser diode facets

    NASA Technical Reports Server (NTRS)

    Dholakia, Anil R. (Inventor)

    1990-01-01

    Bars of integral laser diode devices cleaved from a wafer are placed with their p regions abutting and n regions abutting. A thin BeCu mask having alternate openings and strips of the same width as the end facets is used to mask the n region interfaces so that multiple bars can be partially coated over their exposed p regions with a reflective or partial reflective coating. The partial coating permits identification of the emitting facet from the fully coated back facet during a later device mounting procedure.

  5. Partially coherent contrast-transfer-function approximation.

    PubMed

    Nesterets, Yakov I; Gureyev, Timur E

    2016-04-01

    The contrast-transfer-function (CTF) approximation, widely used in various phase-contrast imaging techniques, is revisited. CTF validity conditions are extended to a wide class of strongly absorbing and refracting objects, as well as to nonuniform partially coherent incident illumination. Partially coherent free-space propagators, describing amplitude and phase in-line contrast, are introduced and their properties are investigated. The present results are relevant to the design of imaging experiments with partially coherent sources, as well as to the analysis and interpretation of the corresponding images. PMID:27140752

  6. Fluctuation theorem for partially masked nonequilibrium dynamics.

    PubMed

    Shiraishi, Naoto; Sagawa, Takahiro

    2015-01-01

    We establish a generalization of the fluctuation theorem for partially masked nonequilibrium dynamics. We introduce a partial entropy production with a subset of all possible transitions, and show that the partial entropy production satisfies the integral fluctuation theorem. Our result reveals the fundamental properties of a broad class of autonomous as well as nonautonomous nanomachines. In particular, our result gives a unified fluctuation theorem for both autonomous and nonautonomous Maxwell's demons, where mutual information plays a crucial role. Furthermore, we derive a fluctuation-dissipation theorem that relates nonequilibrium stationary current to two kinds of equilibrium fluctuations. PMID:25679593

  7. Fluctuation theorem for partially masked nonequilibrium dynamics

    NASA Astrophysics Data System (ADS)

    Shiraishi, Naoto; Sagawa, Takahiro

    2015-01-01

    We establish a generalization of the fluctuation theorem for partially masked nonequilibrium dynamics. We introduce a partial entropy production with a subset of all possible transitions, and show that the partial entropy production satisfies the integral fluctuation theorem. Our result reveals the fundamental properties of a broad class of autonomous as well as nonautonomous nanomachines. In particular, our result gives a unified fluctuation theorem for both autonomous and nonautonomous Maxwell's demons, where mutual information plays a crucial role. Furthermore, we derive a fluctuation-dissipation theorem that relates nonequilibrium stationary current to two kinds of equilibrium fluctuations.

  8. Complex partial status epilepticus: a recurrent problem.

    PubMed Central

    Cockerell, O C; Walker, M C; Sander, J W; Shorvon, S D

    1994-01-01

    Twenty patients with complex partial status epilepticus were identified retrospectively from a specialist neurology hospital. Seventeen patients experienced recurrent episodes of complex partial status epilepticus, often occurring at regular intervals, usually over many years, and while being treated with effective anti-epileptic drugs. No unifying cause for the recurrences, and no common epilepsy aetiologies, were identified. In spite of the frequency of recurrence and length of history, none of the patients showed any marked evidence of cognitive or neurological deterioration. Complex partial status epilepticus is more common than is generally recognised, should be differentiated from other forms of non-convulsive status, and is often difficult to treat. PMID:8021671

  9. Manifest duality for partially massless higher spins

    NASA Astrophysics Data System (ADS)

    Hinterbichler, Kurt; Joyce, Austin

    2016-09-01

    In four dimensions, partially massless fields of all spins and depths possess a duality invariance akin to electric-magnetic duality. We construct metric-like gauge invariant curvature tensors for partially massless fields of all integer spins and depths, and show how the partially massless equations of motion can be recovered from first order field equations and Bianchi identities for these curvatures. This formulation displays duality in its manifestly local and covariant form, in which it acts to interchange the field equations and Bianchi identities.

  10. Circulant states with positive partial transpose

    SciTech Connect

    Chruscinski, Dariusz; Kossakowski, Andrzej

    2007-09-15

    We construct a large class of quantum dxd states which are positive under partial transposition (so called PPT states). The construction is based on certain direct sum decomposition of the total Hilbert space displaying characteristic circular structure - that is why we call them circulant states. It turns out that partial transposition maps any such decomposition into another one and hence both original density matrix and its partially transposed partner share similar cyclic properties. This class contains many well-known examples of PPT states from the literature and gives rise to a huge family of completely new states.

  11. Effect of partial absorption on diffusion with resetting.

    PubMed

    Whitehouse, Justin; Evans, Martin R; Majumdar, Satya N

    2013-02-01

    The effect of partial absorption on a diffusive particle which stochastically resets its position with a finite rate r is considered. The particle is absorbed by a target at the origin with absorption "velocity" a; as the velocity a approaches ∞ the absorption property of the target approaches that of a perfectly absorbing target. The effect of partial absorption on first-passage time problems is studied, in particular, it is shown that the mean time to absorption (MTA) is increased by an additive term proportional to 1/a. The results are extended to multiparticle systems where independent searchers, initially uniformly distributed with a given density, look for a single immobile target. It is found that the average survival probability P(av) is modified by a multiplicative factor which is a function of 1/a, whereas the decay rate of the typical survival probability P(typ) is decreased by an additive term proportional to 1/a.

  12. Effect of partial absorption on diffusion with resetting

    NASA Astrophysics Data System (ADS)

    Whitehouse, Justin; Evans, Martin R.; Majumdar, Satya N.

    2013-02-01

    The effect of partial absorption on a diffusive particle which stochastically resets its position with a finite rate r is considered. The particle is absorbed by a target at the origin with absorption “velocity” a; as the velocity a approaches ∞ the absorption property of the target approaches that of a perfectly absorbing target. The effect of partial absorption on first-passage time problems is studied, in particular, it is shown that the mean time to absorption (MTA) is increased by an additive term proportional to 1/a. The results are extended to multiparticle systems where independent searchers, initially uniformly distributed with a given density, look for a single immobile target. It is found that the average survival probability Pav is modified by a multiplicative factor which is a function of 1/a, whereas the decay rate of the typical survival probability Ptyp is decreased by an additive term proportional to 1/a.

  13. Risk Factors for Postoperative Hemorrhage After Partial Nephrectomy

    PubMed Central

    Jung, Saebin; Min, Gyeong Eun; Chung, Benjamin I.

    2014-01-01

    Purpose To evaluate the frequency and clinical characteristics of postoperative hemorrhage as a complication of partial nephrectomy. Materials and Methods The demographics, physical statistics, tumor size, R.E.N.A.L. nephrometry score, operative method, warm ischemic time, and presence of postoperative hemorrhage and its severity and method of intervention were examined in 300 partial nephrectomy patients in two medical centers (Stanford Medical Center and Kyung Hee University Medical Center) between March 2000 and March 2012. Results Of the 300 subjects, 13 (4.3%) experienced postoperative hemorrhage severe enough to require intervention more invasive than transfusion (Clavien grade III or higher). Univariate analysis of the bleeding and nonbleeding groups showed that whereas age, ischemic time, tumor size and stage, body mass index, American Society of Anesthesiologists class, and operative method did not differ significantly, the exophyticity (E) score was significantly higher for severe postoperative hemorrhage (p=0.04). However, multivariate analysis showed none of the factors to differ significantly. In most of the cases requiring intervention, selective embolization was sufficient, but in one case explorative laparotomy and nephrectomy were required. Clinical characteristics varied significantly among severe hemorrhage cases, with time of onset ranging from the first to the 30th postoperative day and symptoms presenting in a diverse manner, such as gross hematuria and pleuritic chest pain. Computed tomography and angiographic findings were consistent with either arteriovenous fistula or pseudoaneurysms. Conclusions Severe hemorrhage after partial nephrectomy is rare. Nonetheless, with the great variability in presenting symptoms and time of onset after surgery, surgeons should exercise great vigilance during the postoperative care of partial nephrectomy patients. PMID:24466392

  14. Design of partially supervised classifiers for multispectral image data

    NASA Technical Reports Server (NTRS)

    Jeon, Byeungwoo; Landgrebe, David

    1993-01-01

    A partially supervised classification problem is addressed, especially when the class definition and corresponding training samples are provided a priori only for just one particular class. In practical applications of pattern classification techniques, a frequently observed characteristic is the heavy, often nearly impossible requirements on representative prior statistical class characteristics of all classes in a given data set. Considering the effort in both time and man-power required to have a well-defined, exhaustive list of classes with a corresponding representative set of training samples, this 'partially' supervised capability would be very desirable, assuming adequate classifier performance can be obtained. Two different classification algorithms are developed to achieve simplicity in classifier design by reducing the requirement of prior statistical information without sacrificing significant classifying capability. The first one is based on optimal significance testing, where the optimal acceptance probability is estimated directly from the data set. In the second approach, the partially supervised classification is considered as a problem of unsupervised clustering with initially one known cluster or class. A weighted unsupervised clustering procedure is developed to automatically define other classes and estimate their class statistics. The operational simplicity thus realized should make these partially supervised classification schemes very viable tools in pattern classification.

  15. Evaluation of analytical performance based on partial order methodology.

    PubMed

    Carlsen, Lars; Bruggemann, Rainer; Kenessova, Olga; Erzhigitov, Erkin

    2015-01-01

    Classical measurements of performances are typically based on linear scales. However, in analytical chemistry a simple scale may be not sufficient to analyze the analytical performance appropriately. Here partial order methodology can be helpful. Within the context described here, partial order analysis can be seen as an ordinal analysis of data matrices, especially to simplify the relative comparisons of objects due to their data profile (the ordered set of values an object have). Hence, partial order methodology offers a unique possibility to evaluate analytical performance. In the present data as, e.g., provided by the laboratories through interlaboratory comparisons or proficiency testings is used as an illustrative example. However, the presented scheme is likewise applicable for comparison of analytical methods or simply as a tool for optimization of an analytical method. The methodology can be applied without presumptions or pretreatment of the analytical data provided in order to evaluate the analytical performance taking into account all indicators simultaneously and thus elucidating a "distance" from the true value. In the present illustrative example it is assumed that the laboratories analyze a given sample several times and subsequently report the mean value, the standard deviation and the skewness, which simultaneously are used for the evaluation of the analytical performance. The analyses lead to information concerning (1) a partial ordering of the laboratories, subsequently, (2) a "distance" to the Reference laboratory and (3) a classification due to the concept of "peculiar points".

  16. In-Source Fragmentation and the Sources of Partially Tryptic Peptides in Shotgun Proteomics

    SciTech Connect

    Kim, Jong-Seo; Monroe, Matthew E.; Camp, David G.; Smith, Richard D.; Qian, Wei-Jun

    2013-02-01

    Partially tryptic peptides are often identified in shotgun proteomics using trypsin as the proteolytic enzyme; however, it has been controversial regarding the sources of such partially tryptic peptides. Herein we investigate the impact of in-source fragmentation on shotgun proteomics using three biological samples, including a standard protein mixture, a mouse brain tissue homogenate, and a mouse plasma sample. Since the in-source fragments of a peptide retain the same elution time with its parent fully tryptic peptide, the partially tryptic peptides from in-source fragmentation can be distinguished from the other partially tryptic peptides by plotting the observed retention times against the computationally predicted retention times. Most partially tryptic in-source fragmentation artifacts were misaligned from the linear distribution of fully tryptic peptides. The impact of in-source fragmentation on peptide identifications was clearly significant in a less complex sample such as a standard protein digest, where ~60 % of unique peptides were observed as partially tryptic peptides from in-source fragmentation. In mouse brain or mouse plasma samples, in-source fragmentation contributed to 1-3 % of all identified peptides. The other major source of partially tryptic peptides in complex biological samples is presumably proteolytic processing by endogenous proteases in the samples. By filtering out the in-source fragmentation artifacts from the identified partially tryptic or non-tryptic peptides, it is possible to directly survey in-vivo proteolytic processing in biological samples such as blood plasma.

  17. Prolonged partial epilepsy: a case report

    SciTech Connect

    Wilson, M.A.

    1980-11-01

    The case study of a patient with prolonged partial epilepsy is presented. There was a discrepancy between the extent of the abnormality seen on the radionuclide angiogram and that seen on the static brain scan.

  18. Partial ASL extensions for stochastic programming.

    SciTech Connect

    Gay, David

    2010-03-31

    partially completed extensions for stochastic programming to the AMPL/solver interface library (ASL).modeling and experimenting with stochastic recourse problems. This software is not primarily for military applications

  19. Clustering stocks using partial correlation coefficients

    NASA Astrophysics Data System (ADS)

    Jung, Sean S.; Chang, Woojin

    2016-11-01

    A partial correlation analysis is performed on the Korean stock market (KOSPI). The difference between Pearson correlation and the partial correlation is analyzed and it is found that when conditioned on the market return, Pearson correlation coefficients are generally greater than those of the partial correlation, which implies that the market return tends to drive up the correlation between stock returns. A clustering analysis is then performed to study the market structure given by the partial correlation analysis and the members of the clusters are compared with the Global Industry Classification Standard (GICS). The initial hypothesis is that the firms in the same GICS sector are clustered together since they are in a similar business and environment. However, the result is inconsistent with the hypothesis and most clusters are a mix of multiple sectors suggesting that the traditional approach of using sectors to determine the proximity between stocks may not be sufficient enough to diversify a portfolio.

  20. Electrogenerative partial oxidation of organic compounds

    SciTech Connect

    Stafford, G.R.

    1984-05-22

    This invention provides an electrochemical process for electrogenerative partial oxidation of methyl-substituted hydrocarbons such as ethane, propylene and toluene. Ethane is oxidized to products such as acetaldehyde and acetic acid, and propylene converts to acrolein and acrylic acid.

  1. Partial nephrectomy in a patient with dwarfism.

    PubMed

    Farber, Nicholas J; Dubin, Justin; Parihar, Jaspreet; Han, Chris; Lasser, Michael S

    2016-08-01

    We describe the case of a 50-year-old male with achondroplastic dwarfism who presents with a renal mass in his left kidney concerning for renal cell carcinoma. The patient successfully underwent a robotic partial nephrectomy, which revealed a T1a renal cell carcinoma. The tumor was excised successfully without any intraoperative complications demonstrating that a robotic partial nephrectomy is technically both safe and effective in patients with achondroplastic dwarfism. PMID:27544562

  2. Coherent diffractive imaging and partial coherence

    NASA Astrophysics Data System (ADS)

    Williams, Garth J.; Quiney, Harry M.; Peele, Andrew G.; Nugent, Keith A.

    2007-03-01

    We formulate coherent diffractive imaging in the framework of partially spatially coherent diffraction. We find that the reconstruction can be critically dependent on the degree of coherence in the illuminating field and that even a small departure from full coherence may invalidate the conventional assumption that a mapping exists between an exit surface wave of finite support and a far field diffraction pattern. We demonstrate that the introduction of sufficient phase curvature in the illumination can overcome the adverse effects of partial coherence.

  3. Free fall - A partial unique motion environment

    NASA Technical Reports Server (NTRS)

    Graybiel, A.

    1980-01-01

    Conditions leading to the elicitation of motion sickness have been divided into two main categories: partial motion environments, in which head movements are required to elicit motion sickness, and complete motion environments, in which independent movements of the head are not required for the production of symptoms. It is postulated that, according to this categorization, free fall constitutes a partial motion environment. In support of this hypothesis evidence is reviewed from Skylab missions, experiments in parabolic flight, and ground-based studies.

  4. Gingival enlargement in partial hemifacial hyperplasia.

    PubMed

    Jagtap, Rasika Ravindra; Deshpande, Gaurav Shekhar

    2014-01-01

    Hemifacial hypertrophy is a rare developmental disorder, characterized by unilateral enlargement of facial tissues. The hemifacial hyperplasia is classified as true hemifacial hypertrophy and partial hemifacial hypertrophy. It is unilateral enlargement of viscerocranial condition in which not all structures are enlarged. We present a rare case of gingival enlargement in partial hemifacial hyperplasia highlighting the clinical and radiological findings with the corrective treatment offered for gingival enlargement.

  5. Spreading paths in partially observed social networks

    NASA Astrophysics Data System (ADS)

    Onnela, Jukka-Pekka; Christakis, Nicholas A.

    2012-03-01

    Understanding how and how far information, behaviors, or pathogens spread in social networks is an important problem, having implications for both predicting the size of epidemics, as well as for planning effective interventions. There are, however, two main challenges for inferring spreading paths in real-world networks. One is the practical difficulty of observing a dynamic process on a network, and the other is the typical constraint of only partially observing a network. Using static, structurally realistic social networks as platforms for simulations, we juxtapose three distinct paths: (1) the stochastic path taken by a simulated spreading process from source to target; (2) the topologically shortest path in the fully observed network, and hence the single most likely stochastic path, between the two nodes; and (3) the topologically shortest path in a partially observed network. In a sampled network, how closely does the partially observed shortest path (3) emulate the unobserved spreading path (1)? Although partial observation inflates the length of the shortest path, the stochastic nature of the spreading process also frequently derails the dynamic path from the shortest path. We find that the partially observed shortest path does not necessarily give an inflated estimate of the length of the process path; in fact, partial observation may, counterintuitively, make the path seem shorter than it actually is.

  6. The role of partial knowledge in statistical word learning.

    PubMed

    Yurovsky, Daniel; Fricker, Damian C; Yu, Chen; Smith, Linda B

    2014-02-01

    A critical question about the nature of human learning is whether it is an all-or-none or a gradual, accumulative process. Associative and statistical theories of word learning rely critically on the later assumption: that the process of learning a word's meaning unfolds over time. That is, learning the correct referent for a word involves the accumulation of partial knowledge across multiple instances. Some theories also make an even stronger claim: partial knowledge of one word-object mapping can speed up the acquisition of other word-object mappings. We present three experiments that test and verify these claims by exposing learners to two consecutive blocks of cross-situational learning, in which half of the words and objects in the second block were those that participants failed to learn in Block 1. In line with an accumulative account, Re-exposure to these mis-mapped items accelerated the acquisition of both previously experienced mappings and wholly new word-object mappings. But how does partial knowledge of some words speed the acquisition of others? We consider two hypotheses. First, partial knowledge of a word could reduce the amount of information required for it to reach threshold, and the supra-threshold mapping could subsequently aid in the acquisition of new mappings. Alternatively, partial knowledge of a word's meaning could be useful for disambiguating the meanings of other words even before the threshold of learning is reached. We construct and compare computational models embodying each of these hypotheses and show that the latter provides a better explanation of the empirical data.

  7. The role of partial knowledge in statistical word learning

    PubMed Central

    Fricker, Damian C.; Yu, Chen; Smith, Linda B.

    2013-01-01

    A critical question about the nature of human learning is whether it is an all-or-none or a gradual, accumulative process. Associative and statistical theories of word learning rely critically on the later assumption: that the process of learning a word's meaning unfolds over time. That is, learning the correct referent for a word involves the accumulation of partial knowledge across multiple instances. Some theories also make an even stronger claim: Partial knowledge of one word–object mapping can speed up the acquisition of other word–object mappings. We present three experiments that test and verify these claims by exposing learners to two consecutive blocks of cross-situational learning, in which half of the words and objects in the second block were those that participants failed to learn in Block 1. In line with an accumulative account, Re-exposure to these mis-mapped items accelerated the acquisition of both previously experienced mappings and wholly new word–object mappings. But how does partial knowledge of some words speed the acquisition of others? We consider two hypotheses. First, partial knowledge of a word could reduce the amount of information required for it to reach threshold, and the supra-threshold mapping could subsequently aid in the acquisition of new mappings. Alternatively, partial knowledge of a word's meaning could be useful for disambiguating the meanings of other words even before the threshold of learning is reached. We construct and compare computational models embodying each of these hypotheses and show that the latter provides a better explanation of the empirical data. PMID:23702980

  8. The role of partial knowledge in statistical word learning.

    PubMed

    Yurovsky, Daniel; Fricker, Damian C; Yu, Chen; Smith, Linda B

    2014-02-01

    A critical question about the nature of human learning is whether it is an all-or-none or a gradual, accumulative process. Associative and statistical theories of word learning rely critically on the later assumption: that the process of learning a word's meaning unfolds over time. That is, learning the correct referent for a word involves the accumulation of partial knowledge across multiple instances. Some theories also make an even stronger claim: partial knowledge of one word-object mapping can speed up the acquisition of other word-object mappings. We present three experiments that test and verify these claims by exposing learners to two consecutive blocks of cross-situational learning, in which half of the words and objects in the second block were those that participants failed to learn in Block 1. In line with an accumulative account, Re-exposure to these mis-mapped items accelerated the acquisition of both previously experienced mappings and wholly new word-object mappings. But how does partial knowledge of some words speed the acquisition of others? We consider two hypotheses. First, partial knowledge of a word could reduce the amount of information required for it to reach threshold, and the supra-threshold mapping could subsequently aid in the acquisition of new mappings. Alternatively, partial knowledge of a word's meaning could be useful for disambiguating the meanings of other words even before the threshold of learning is reached. We construct and compare computational models embodying each of these hypotheses and show that the latter provides a better explanation of the empirical data. PMID:23702980

  9. Detrecting and Locating Partial Discharges in Transformers

    SciTech Connect

    Shourbaji, A.; Richards, R.; Kisner, R. A.; Hardy, J.

    2005-02-04

    A collaborative research between the Oak Ridge National Laboratory (ORNL), the American Electric Power (AEP), the Tennessee Valley Authority (TVA), and the State of Ohio Energy Office (OEO) has been formed to conduct a feasibility study to detect and locate partial discharges (PDs) inside large transformers. The success of early detection of the PDs is necessary to avoid costly catastrophic failures that can occur if the process of PD is ignored. The detection method under this research is based on an innovative technology developed by ORNL researchers using optical methods to sense the acoustical energy produced by the PDs. ORNL researchers conducted experimental studies to detect PD using an optical fiber as an acoustic sensor capable of detecting acoustical disturbances at any point along its length. This technical approach also has the potential to locate the point at which the PD was sensed within the transformer. Several optical approaches were experimentally investigated, including interferometric detection of acoustical disturbances along the sensing fiber, light detection and ranging (LIDAR) techniques using frequency modulation continuous wave (FMCW), frequency modulated (FM) laser with a multimode fiber, FM laser with a single mode fiber, and amplitude modulated (AM) laser with a multimode fiber. The implementation of the optical fiber-based acoustic measurement technique would include installing a fiber inside a transformer allowing real-time detection of PDs and determining their locations. The fibers are nonconductive and very small (core plus cladding are diameters of 125 μm for single-mode fibers and 230 μm for multimode fibers). The research identified the capabilities and limitations of using optical technology to detect and locate sources of acoustical disturbances such as in PDs in large transformers. Amplitude modulation techniques showed the most promising results and deserve further research to better quantify the technique’s sensitivity

  10. Prospective study on laser-assisted laparascopic partial nephrectomy

    NASA Astrophysics Data System (ADS)

    Sroka, Ronald; Hennig, Georg; Zilinberg, Katja; Khoder, Wael Y.

    2012-02-01

    Introduction: Developments in laparoscopic partial nephrectomy (LPN) opened a demand for surgical tools compatible with laparoscopic manipulations to make laser assisted technique safe, feasible and reproducible. Warm ischemia and bleeding during laparoscopic partial nephrectomy place technical constraints on surgeons. Therefore it was the aim to develop a safe and effective laser assisted partial nephrectomy technique without need for ischemia. Patients and methods: A diode laser emitting light at 1318nm in cw mode was coupled into a bare fibre (core diameter 600 μm) thus able to transfer up to 100W to the tissue. After dry lab experience, a total of 10 patients suffering from kidney malformations underwent laparoscopic/retroperitoneoscopic partial nephrectomy. Clinically, postoperative renal function and serum c-reactive protein (CRP) were monitored. Laser induced coagulation depth and effects on resection margins were evaluated. Demographic, clinical and follow-up data are presented. Using a commercial available fibre guidance instrument for lanringeal intervention, the demands on an innovative laser fibre guidance instrument for the laser assisted laparoscopic partial nephrectomy (LLPN) are summarized. Results: Overall, all laparascopic intervention were succesfull and could be performed without conversion to open surgery. Mean operative time and mean blood loss were comparable to conventional open and laparascopic approaches. Laser assisted resection of the kidney tissue took max 15min. After extirpation of the tumours all patients showed clinical favourable outcome during follow up period. Tumour sizes were measured to be up 5cm in diameter. The depth of the coagulation on the removed tissue ranged between <1 to 2mm without effect on histopathological evaluation of tumours or resection margin. As the surface of the remaining kidney surface was laser assisted coagulated after removal. The sealing of the surface was induced by a slightly larger coagulation

  11. Texture of fermion mass matrices in partially unified theories

    SciTech Connect

    Dutta, B. |; Nandi, S. |

    1996-12-31

    We investigate the texture of fermion mass matrices in theories with partial unification (for example, SU(2){sub L} {times} SU(2){sub R} {times} SU(4){sub c}) at a scale of {approximately} 10{sup 12} GeV. Starting with the low energy values of the masses and the mixing angles, we find only two viable textures with at most four texture zeros. One of these corresponds to a somewhat modified Fritzsch textures. A theoretical derivation of these textures leads to new interesting relations among the masses and the mixing angles. 13 refs.

  12. Is robotic partial nephrectomy convenient for solitary kidney?

    PubMed

    Kaouk, Jihad H; Malkoç, Ercan

    2016-09-01

    Nephron sparing surgery (NSS) is the gold standard treatment option for patients with a solitary kidney in order to preserve renal function. Open partial nephrectomy (OPN) has been long considered the standard care for NSS. Robotic partial nephrectomy (RPN) is being gradually used more commonly even for solitary kidney and complex tumors. There was no difference between RPN and OPN regarding the rate of intraoperative-postoperative complications and positive surgical margin (PSM) (RPN: 7.5%, OPN: 8%) for patients with solitary kidney who underwent partial nephrectomy for small renal masses. Warm ischemia time (WIT) in all of our studies was within the safe range of <25 minutes which is acceptable ischemia time for robotic approaches. More studies are needed in order to evaluate kidney function. In conclusion with increasing experience, solitary kidney tumors can be managed safely with robotic approach. For patients having complex tumors with a potential of WIT >25 minutes, administration of intracorporeal ice slush during surgery may be considered. PMID:27635284

  13. Is robotic partial nephrectomy convenient for solitary kidney?

    PubMed Central

    Kaouk, Jihad H.; Malkoç, Ercan

    2016-01-01

    Nephron sparing surgery (NSS) is the gold standard treatment option for patients with a solitary kidney in order to preserve renal function. Open partial nephrectomy (OPN) has been long considered the standard care for NSS. Robotic partial nephrectomy (RPN) is being gradually used more commonly even for solitary kidney and complex tumors. There was no difference between RPN and OPN regarding the rate of intraoperative-postoperative complications and positive surgical margin (PSM) (RPN: 7.5%, OPN: 8%) for patients with solitary kidney who underwent partial nephrectomy for small renal masses. Warm ischemia time (WIT) in all of our studies was within the safe range of <25 minutes which is acceptable ischemia time for robotic approaches. More studies are needed in order to evaluate kidney function. In conclusion with increasing experience, solitary kidney tumors can be managed safely with robotic approach. For patients having complex tumors with a potential of WIT >25 minutes, administration of intracorporeal ice slush during surgery may be considered. PMID:27635284

  14. Partial nitrification for nitrogen removal from sanitary landfill leachate.

    PubMed

    Spagni, Alessandro; Psaila, Giuliana; Rizzo, Andrea

    2014-09-19

    Biological nitrogen removal using nitrite as a shortcut has recently been proposed for the treatment of high strength landfill leachate. The aim of this study was to assess the application of the SHARON (Single reactor High activity Ammonium Removal Over Nitrite) process for the partial nitrification of leachate generated in old landfills. Particular attention was given to the start-up phase of the process. This study demonstrated that partial nitrification can be obtained when treating raw leachate after biomass acclimation. Only a fraction (50-70%) of the ammonia present in the leachate can be oxidised due to a limited amount of alkalinity available. Stable nitritation was obtained by applying a hydraulic retention time (HRT) of 4-5 d, which is higher than the values proposed for the effluent of anaerobic digesters. This higher HRT could probably be allowed by the high concentration of free ammonia present in the leachate, which could severely inhibit the growth of nitrite-oxidising bacteria.

  15. [Repair of the traumata caused by partial laryngectomy].

    PubMed

    Guo, Z; Fu, X; Wang, J

    1994-01-01

    At present, the wound caused by partial laryngectomy are repaired by using many kinds of tissues in order to avoid infection, granuloma and laryngeal stenosis. It is unclear whether the traumata has to be repaired by transplant tissues or non-repaired traumata will lead to laryngeal dysfunction. This article analyzed 162 patients who received partial laryngectomy from April 1980 to March 1992. These patients had been divided into two groups: repaired group (78 cases) and non-repaired group (84 cases). Repair material used included sternohyoideus fascia (57 cases), thyro-hyoideus fascia (9 cases), throat musculus flap (6 cases), stemocleido-mastoideus fascia (3 cases) and throat flap (3 cases). The result indicated that there were no significant differences in respiration swallow recovery time and so on. So we concluded that non-repaired group has similar curative effect to repaired group and repairing the traumata (especially minor traumata) with the fascia around the traumata is an effective method.

  16. Hydrodynamic flow of ions and atoms in partially ionized plasmas

    NASA Astrophysics Data System (ADS)

    Nemirovsky, R. A.; Fredkin, D. R.; Ron, A.

    2002-12-01

    We have derived the hydrodynamic equations of motion for a partially ionized plasma, when the ionized component and the neutral components have different flow velocities and kinetic temperatures. Starting from the kinetic equations for a gas of ions and a gas of atoms we have considered various processes of encounters between the two species: self-collisions, interspecies collisions, ionization, recombination, and charge exchange. Our results were obtained by developing a general approach for the hydrodynamics of a gas in a binary mixture, in particular when the components drift with respect to each other. This was applied to a partially ionized plasma, when the neutral-species gas and the charged-species gas have separate velocities. We have further suggested a generalized version of the relaxation time approximation and obtained the contributions of the interspecies encounters to the transport equations.

  17. Hydrodynamic flow of ions and atoms in partially ionized plasmas.

    PubMed

    Nemirovsky, R A; Fredkin, D R; Ron, A

    2002-12-01

    We have derived the hydrodynamic equations of motion for a partially ionized plasma, when the ionized component and the neutral components have different flow velocities and kinetic temperatures. Starting from the kinetic equations for a gas of ions and a gas of atoms we have considered various processes of encounters between the two species: self-collisions, interspecies collisions, ionization, recombination, and charge exchange. Our results were obtained by developing a general approach for the hydrodynamics of a gas in a binary mixture, in particular when the components drift with respect to each other. This was applied to a partially ionized plasma, when the neutral-species gas and the charged-species gas have separate velocities. We have further suggested a generalized version of the relaxation time approximation and obtained the contributions of the interspecies encounters to the transport equations.

  18. Partial iterated function system-based fractal image coding

    NASA Astrophysics Data System (ADS)

    Wang, Zhou; Yu, Ying Lin

    1996-06-01

    A recent trend in computer graphics and image processing has been to use iterated function system (IFS) to generate and describe images. Barnsley et al. presented the conception of fractal image compression and Jacquin was the first to propose a fully automatic gray scale still image coding algorithm. This paper introduces a generalization of basic IFS, leading to a conception of partial iterated function system (PIFS). A PIFS operator is contractive under certain conditions and when it is applied to generate an image, only part of it is actually iteratedly applied. PIFS provides us a flexible way to combine fractal coding with other image coding techniques and many specific algorithms can be derived from it. On the basis of PIFS, we implement a partial fractal block coding (PFBC) algorithm and compare it with basic IFS based fractal block coding algorithm. Experimental results show that coding efficiency is improved and computation time is reduced while image fidelity does not degrade very much.

  19. [Partial pensions: futuristic social policy innovation or only an alibi?].

    PubMed

    Oswald, C; George, R; Viebrok, H

    1996-01-01

    The 1992 Pension Reform Act makes it possible that all old age pensions in Germany can be claimed as partial pensions with the objective of extending working life and creating the opportunity of a phased exit from the labour force. Disappointingly little use was made of this new form of flexible retirement. One main reason seems to be the unfavourable labour market situation in Germany, favouring an early exit from the labour force. This article investigates to what extent the design of the partial pension is responsible for its failure and how it could be modified in order to create, in accordance with the new "Part Time Work in Old Age Act", a system of gradual retirement which helps to stabilise the financial base of the pension system.

  20. Skin friction measurement with partially exposed polymer dispersed liquid crystals

    NASA Technical Reports Server (NTRS)

    Parmar, D. S.; Holmes, H. K.

    1993-01-01

    Partially exposed polymer dispersed liquid crystal thin film (10-25 microns) deposited on a flat glass substrate has been used for the first time to measure skin friction. Utilizing the shear-stress-induced director reorientation in the partially exposed liquid-crystal droplets, optical transmission under crossed polarization has been measured as a function of the air flow differential pressure. Direct measurement of the skin friction with a skin friction drag balance, under the same aerodynamic conditions, lets us correlate the skin friction with optical transmission. This provides a unique technique for the direct measurement of skin friction from the transmitted light intensity. The results are in excellent agreement with the model suggested in this paper.

  1. Emergency laparoscopic partial splenectomy for ruptured spleen: A case report

    PubMed Central

    Cai, Yun-Qiang; Li, Chun-Lin; Zhang, Hua; Wang, Xin; Peng, Bing

    2014-01-01

    Splenic rupture is a common consequence of blunt abdominal trauma. Emergency splenectomy is indicated when conservative management is not effective. With better understanding of the immunologic function of the spleen, surgeons have begun to perform the splenic-preserving surgery. However, it is technical challenge to perform emergency laparoscopic partial splenectomy for patient with spleen rupture. A 15-year-old male patient suffered from grade III spleen injury basing on the American association for the surgery of trauma splenic injury scale. Conservative treatment failed to success basing on the dramatically decreased hemoglobin level. During the laparoscopic exploration, we found that two individual ruptures were associated with the upper pole of spleen. An emergency laparoscopic partial splenectomy was successfully carried out. The operative time was approximate 150 min and the estimated blood loss was 200 mL. The post-operative course was uneventful and the patient was discharged on the 7th post-operative day. PMID:25516684

  2. Supercoiling, knotting and replication fork reversal in partially replicated plasmids

    PubMed Central

    Olavarrieta, L.; Martínez-Robles, M. L.; Sogo, J. M.; Stasiak, A.; Hernández, P.; Krimer, D. B.; Schvartzman, J. B.

    2002-01-01

    To study the structure of partially replicated plasmids, we cloned the Escherichia coli polar replication terminator TerE in its active orientation at different locations in the ColE1 vector pBR18. The resulting plasmids, pBR18-TerE@StyI and pBR18-TerE@EcoRI, were analyzed by neutral/neutral two-dimensional agarose gel electrophoresis and electron microscopy. Replication forks stop at the Ter–TUS complex, leading to the accumulation of specific replication intermediates with a mass 1.26 times the mass of non-replicating plasmids for pBR18-TerE@StyI and 1.57 times for pBR18-TerE@EcoRI. The number of knotted bubbles detected after digestion with ScaI and the number and electrophoretic mobility of undigested partially replicated topoisomers reflect the changes in plasmid topology that occur in DNA molecules replicated to different extents. Exposure to increasing concentrations of chloroquine or ethidium bromide revealed that partially replicated topoisomers (CCCRIs) do not sustain positive supercoiling as efficiently as their non-replicating counterparts. It was suggested that this occurs because in partially replicated plasmids a positive ΔLk is absorbed by regression of the replication fork. Indeed, we showed by electron microscopy that, at least in the presence of chloroquine, some of the CCCRIs of pBR18-Ter@StyI formed Holliday-like junction structures characteristic of reversed forks. However, not all the positive supercoiling was absorbed by fork reversal in the presence of high concentrations of ethidium bromide. PMID:11809877

  3. Telecloning of qudits via partially entangled states

    NASA Astrophysics Data System (ADS)

    Araneda, Gabriel; Cisternas, Nataly; Delgado, Aldo

    2016-08-01

    We study the process of quantum telecloning of d-dimensional pure quantum states using partially entangled pure states as quantum channel. This process efficiently mixes optimal universal symmetric cloning with quantum teleportation. It is shown that it is possible to implement universal symmetric telecloning in a probabilistic way using unambiguous state discrimination and quantum state separation schemes. It is also shown that other strategies, such as minimum error discrimination, lead to a decrease in the fidelity of the copies and that certain partially entangled pure states with maximal Schmidt rank lead to an average telecloning fidelity which is always above the optimal fidelity of measuring and preparation of quantum states. We also discuss the case of partially entangled pure states with non-maximal Schmidt rank. The results presented here are valid for arbitrary numbers of copies of a single-input qudit state of any dimension.

  4. Thin film oxygen partial pressure sensor

    NASA Technical Reports Server (NTRS)

    Wortman, J. J.; Harrison, J. W.; Honbarrier, H. L.; Yen, J.

    1972-01-01

    The development is described of a laboratory model oxygen partial pressure sensor using a sputtered zinc oxide thin film. The film is operated at about 400 C through the use of a miniature silicon bar. Because of the unique resistance versus temperature relation of the silicon bar, control of the operational temperature is achieved by controlling the resistance. A circuit for accomplishing this is described. The response of sputtered zinc oxide films of various thicknesses to oxygen, nitrogen, argon, carbon dioxide, and water vapor caused a change in the film resistance. Over a large range, film conductance varied approximately as the square root of the oxygen partial pressure. The presence of water vapor in the gas stream caused a shift in the film conductance at a given oxygen partial pressure. A theoretical model is presented to explain the characteristic features of the zinc oxide response to oxygen.

  5. Partial connectivity increases cultural accumulation within groups.

    PubMed

    Derex, Maxime; Boyd, Robert

    2016-03-15

    Complex technologies used in most human societies are beyond the inventive capacities of individuals. Instead, they result from a cumulative process in which innovations are gradually added to existing cultural traits across many generations. Recent work suggests that a population's ability to develop complex technologies is positively affected by its size and connectedness. Here, we present a simple computer-based experiment that compares the accumulation of innovations by fully and partially connected groups of the same size in a complex fitness landscape. We find that the propensity to learn from successful individuals drastically reduces cultural diversity within fully connected groups. In comparison, partially connected groups produce more diverse solutions, and this diversity allows them to develop complex solutions that are never produced in fully connected groups. These results suggest that explanations of ancestral patterns of cultural complexity may need to consider levels of population fragmentation and interaction patterns between partially isolated groups. PMID:26929364

  6. Partial connectivity increases cultural accumulation within groups

    PubMed Central

    Boyd, Robert

    2016-01-01

    Complex technologies used in most human societies are beyond the inventive capacities of individuals. Instead, they result from a cumulative process in which innovations are gradually added to existing cultural traits across many generations. Recent work suggests that a population’s ability to develop complex technologies is positively affected by its size and connectedness. Here, we present a simple computer-based experiment that compares the accumulation of innovations by fully and partially connected groups of the same size in a complex fitness landscape. We find that the propensity to learn from successful individuals drastically reduces cultural diversity within fully connected groups. In comparison, partially connected groups produce more diverse solutions, and this diversity allows them to develop complex solutions that are never produced in fully connected groups. These results suggest that explanations of ancestral patterns of cultural complexity may need to consider levels of population fragmentation and interaction patterns between partially isolated groups. PMID:26929364

  7. Scintillations of partially coherent Laguerre Gaussian beams

    NASA Astrophysics Data System (ADS)

    Yüceer, M.; Eyyuboğlu, H. T.; Lukin, I. P.

    2010-12-01

    Scintillations of Laguerre-Gaussian (LG) beams for weak atmospheric turbulence conditions are derived for on-axis receiver positions by using Huygens-Fresnel (HF) method in semi-analytic fashion. Numerical evaluations indicate that at the fully coherent limit, higher values of radial mode numbers will give rise to more scintillations, at medium and low partial coherence levels, particularly at longer propagation distances, scintillations will fall against rises in radial mode numbers. At small source sizes, the scintillations of LG beams having full coherence will initially rise, reaching saturation at large source sizes. For LG beams with low partial coherence levels, a steady fall toward the larger source sizes is observed. Partially coherent beams of medium levels generally exhibit a rising trend toward the large source sizes, also changing the respective positions of the related curves. Beams of low coherence levels will be less affected by the variations in the refractive index structure constant.

  8. Partial connectivity increases cultural accumulation within groups.

    PubMed

    Derex, Maxime; Boyd, Robert

    2016-03-15

    Complex technologies used in most human societies are beyond the inventive capacities of individuals. Instead, they result from a cumulative process in which innovations are gradually added to existing cultural traits across many generations. Recent work suggests that a population's ability to develop complex technologies is positively affected by its size and connectedness. Here, we present a simple computer-based experiment that compares the accumulation of innovations by fully and partially connected groups of the same size in a complex fitness landscape. We find that the propensity to learn from successful individuals drastically reduces cultural diversity within fully connected groups. In comparison, partially connected groups produce more diverse solutions, and this diversity allows them to develop complex solutions that are never produced in fully connected groups. These results suggest that explanations of ancestral patterns of cultural complexity may need to consider levels of population fragmentation and interaction patterns between partially isolated groups.

  9. Partial Thickness Rotator Cuff Tears: Current Concepts

    PubMed Central

    Matthewson, Graeme; Beach, Cara J.; Nelson, Atiba A.; Woodmass, Jarret M.; Ono, Yohei; Boorman, Richard S.; Lo, Ian K. Y.; Thornton, Gail M.

    2015-01-01

    Partial thickness rotator cuff tears are a common cause of pain in the adult shoulder. Despite their high prevalence, the diagnosis and treatment of partial thickness rotator cuff tears remains controversial. While recent studies have helped to elucidate the anatomy and natural history of disease progression, the optimal treatment, both nonoperative and operative, is unclear. Although the advent of arthroscopy has improved the accuracy of the diagnosis of partial thickness rotator cuff tears, the number of surgical techniques used to repair these tears has also increased. While multiple repair techniques have been described, there is currently no significant clinical evidence supporting more complex surgical techniques over standard rotator cuff repair. Further research is required to determine the clinical indications for surgical and nonsurgical management, when formal rotator cuff repair is specifically indicated and when biologic adjunctive therapy may be utilized. PMID:26171251

  10. On partially massless theory in 3 dimensions

    SciTech Connect

    Alexandrov, Sergei; Deffayet, Cédric

    2015-03-24

    We analyze the first-order formulation of the ghost-free bigravity model in three-dimensions known as zwei-dreibein gravity. For a special choice of parameters, it was argued to have an additional gauge symmetry and give rise to a partially massless theory. We provide a thorough canonical analysis and identify that whether the theory becomes partially massless depends on the form of the stability condition of the secondary constraint responsible for the absence of the ghost. Generically, it is found to be an equation for a Lagrange multiplier implying that partially massless zwei-dreibein gravity does not exist. However, for special backgrounds this condition is identically satisfied leading to the presence of additional symmetries, which however disappear at quadratic order in perturbations.

  11. [Fiber-reinforced adhesive partial dentures].

    PubMed

    Kreulen, C M

    2003-06-01

    Dental applications of fiber-reinforced polymers include adhesive partial dentures. Dental resin composite materials can be reinforced by several types of fibres. Fiber orientation, proper wetting of the fibers by the resin and fiber volume are important. An application of fiber reinforced composites is the composite inlay bridge. This paper deals with some aspects of this type of adhesive partial denture. Advantages include the satisfactory esthetics and the minimally invasive character. Not clear yet is the long-term survival. The adhesive properties of fiber-reinforced adhesive partial dentures require an adaptation of the current dental philosophy, in which direct and indirect restorative techniques can be combined. An increase in knowledge and experience is needed to determine the dental applications. PMID:12852063

  12. Virtual environment application with partial gravity simulation

    NASA Technical Reports Server (NTRS)

    Ray, David M.; Vanchau, Michael N.

    1994-01-01

    To support manned missions to the surface of Mars and missions requiring manipulation of payloads and locomotion in space, a training facility is required to simulate the conditions of both partial and microgravity. A partial gravity simulator (Pogo) which uses pneumatic suspension is being studied for use in virtual reality training. Pogo maintains a constant partial gravity simulation with a variation of simulated body force between 2.2 and 10 percent, depending on the type of locomotion inputs. this paper is based on the concept and application of a virtual environment system with Pogo including a head-mounted display and glove. The reality engine consists of a high end SGI workstation and PC's which drive Pogo's sensors and data acquisition hardware used for tracking and control. The tracking system is a hybrid of magnetic and optical trackers integrated for this application.

  13. Impact of hydrogen partial pressure on coal liquefaction. Final technical report

    SciTech Connect

    Kang, D.; Hoover, D.S.; Schweighardt, F.K.

    1984-06-01

    This program was conducted to determine the effects of hydrogen partial pressure on the SRC-I direct coal liquefaction process and SRC-I Demonstration Plant design. A native solvent was produced in quantity and slurried with Kentucky number 9 Mulford coal in a series of coal liquefaction runs under varying hydrogen gas rates, temperatures, residence times, and hydrogen partial pressures. The results showed that hydrogen partial pressure significantly affected product distribution; the magnitude of the effect was comparable to changes in temperature and residence time. Also, the impact of hydrogen partial pressure was enhanced by increases in both temperature and residence time. Operating at low hydrogen partial pressure did not show any apparent advantage; it reduced coal conversion, reduced oil yield, and had a detrimental effect on the yield distribution of other products. An increase in hydrogen partial pressure had the following effects: increased coal conversion; increased conversion of asphaltenes and preasphaltenes to lighter products; significantly increased the oil yield; increased light gas yields; decreased sulfur content in the SRC; increased hydrogen content of the recycle solvent; and increased hydrogen consumption. This study strongly suggests that further studies should be conducted to optimize the effects of hydrogen partial pressure on the process, both within and, preferably, beyond the constraints of the current basic SRC-I design, considering the major impact of this variable on the process. 10 references, 37 figures, 10 tables.

  14. Adult case of partial trisomy 9q

    PubMed Central

    2010-01-01

    Background Complete and partial trisomy 9 is the fourth most common chromosomal disorder. It is also associated with various congenital characteristics affecting the cranio-facial, skeletal, central nervous, gastrointestinal, cardiac and renal systems. Very few cases have been reported in adults. Partial trisomy 9q is also associated with short stature, poor growth and growth hormone deficiency. This is the first reported case of an extensive endocrinology investigation of short stature in trisomy 9q and the outcome of growth hormone treatment. Case Presentation The case involves a 23-year-old female of pure partial trisomy 9q. The case involves a 23-year old female with pure partial trisomy 9q involving a duplication of 9q22.1 to q32, de novo, confirmed by genetic studies using fluorescene in situ hybridization (FISH) method. The diagnosis was at 6 years of age. She did not demonstrate all the congenital morphologies identified with trisomy 9q disorders especially in relation to multi-organ morphologies. There is also a degree of associated intellectual impairment. At prepuberty, she was referred for poor growth and was diagnosed with partial growth hormone deficiency. She responded very well to treatment with growth hormone and is currently living an independent life with some support. Conclusions Trisomy 9q is associated with short stature and failure to thrive. Growth hormone deficiency should be identified in cases of trisomy 9q and treatment offered. This is the first reported case of response to growth hormone replacement in partial trisomy 9. PMID:20158889

  15. Digital generation of partially coherent vortex beams.

    PubMed

    Perez-Garcia, Benjamin; Yepiz, Adad; Hernandez-Aranda, Raul I; Forbes, Andrew; Swartzlander, Grover A

    2016-08-01

    We present an experimental technique to generate partially coherent vortex beams with an arbitrary azimuthal index using only a spatial light modulator. Our approach is based on digitally simulating the intrinsic randomness of broadband light passing through a spiral phase plate. We illustrate the versatility of the technique by generating partially coherent beams with different coherence lengths and orbital angular momentum content, without any moving optical device. Consequently, we study its cross-correlation function in a wavefront folding interferometer. The comparison with theoretical predictions yields excellent agreement. PMID:27472596

  16. Partial gravity - Human impacts on facility design

    NASA Technical Reports Server (NTRS)

    Capps, Stephen; Moore, Nathan

    1990-01-01

    Partial gravity affects the body differently than earth gravity and microgravity environments. The main difference from earth gravity is human locomotion; while the main dfference from microgravity is the specific updown orientation and reach envelopes which increase volume requirements. Much data are available on earth gravity and microgravity design; however, very little information is available on human reactions to reduced gravity levels in IVA situations (without pressure suits). Therefore, if humans commit to permanent lunar habitation, much research should be conducted in the area of partial gravity effects on habitat design.

  17. Pheochromocytoma Presenting as Partial HELLP Syndrome.

    PubMed

    Daaboul, Yazan; Korjian, Serge; Khalil, Lamis; Nemr, Rita

    2015-01-01

    Diagnosis of pheochromocytoma in partial HELLP syndrome is extremely rare. We report a case of a 25-year-old multigravida woman at 30 weeks of gestation who presented with clinical features consistent with partial HELLP syndrome. Her symptoms were not controlled by pharmacologic therapy, and the patient underwent urgent cesarean section. The patient gave birth to a viable baby, but she sustained an episode of ventricular fibrillation intraoperatively that did not result in any long-term sequelae. The patient's symptoms persisted postoperatively and work-up for secondary etiologies of hypertension demonstrated a right adrenal pheochromocytoma. Following resection, the patient's signs and symptoms resolved, and her lab tests normalized. PMID:26351602

  18. DEVICE FOR CONTROL OF OXYGEN PARTIAL PRESSURE

    DOEpatents

    Bradner, H.; Gordon, H.S.

    1957-12-24

    A device is described that can sense changes in oxygen partial pressure and cause a corresponding mechanical displacement sufficient to actuate meters, valves and similar devices. A piston and cylinder arrangement contains a charge of crystalline metal chelate pellets which have the peculiar property of responding to variations in the oxygen content of the ambient atmosphere by undergoing a change in dimension. A lever system amplifies the relative displacement of the piston in the cylinder, and actuates the controlled valving device. This partial pressure oxygen sensing device is useful in controlled chemical reactions or in respiratory devices such as the oxygen demand meters for high altitude aircraft.

  19. 77 FR 1417 - Partial Approval and Partial Disapproval of Air Quality Implementation Plans; California; San...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    .... Proposed Action On September 9, 2011 (76 FR 55842), EPA proposed to partially approve and partially... approval/disapproval October 1, 2010 (75 FR 60623). SJVUAPCD is scheduled to adopt amendments to Rule 4352.../disapproval January 26, 2010, (75 FR 3996). SJVUAPCD submitted amendments to EPA on July 28, 2011 and...

  20. Methods for producing partially digested restriction DNA fragments and for producing a partially modified PCR product

    DOEpatents

    Wong, Kwong-Kwok

    2000-01-01

    The present invention is an improved method of making a partially modified PCR product from a DNA fragment with a polymerase chain reaction (PCR). In a standard PCR process, the DNA fragment is combined with starting deoxynucleoside triphosphates, a primer, a buffer and a DNA polymerase in a PCR mixture. The PCR mixture is then reacted in the PCR producing copies of the DNA fragment. The improvement of the present invention is adding an amount of a modifier at any step prior to completion of the PCR process thereby randomly and partially modifying the copies of the DNA fragment as a partially modified PCR product. The partially modified PCR product may then be digested with an enzyme that cuts the partially modified PCR product at unmodified sites thereby producing an array of DNA restriction fragments.

  1. An observational and thermodynamic investigation of carbonate partial melting

    NASA Astrophysics Data System (ADS)

    Floess, David; Baumgartner, Lukas P.; Vonlanthen, Pierre

    2015-01-01

    Melting experiments available in the literature show that carbonates and pelites melt at similar conditions in the crust. While partial melting of pelitic rocks is common and well-documented, reports of partial melting in carbonates are rare and ambiguous, mainly because of intensive recrystallization and the resulting lack of criteria for unequivocal identification of melting. Here we present microstructural, textural, and geochemical evidence for partial melting of calcareous dolomite marbles in the contact aureole of the Tertiary Adamello Batholith. Petrographic observations and X-ray micro-computed tomography (X-ray μCT) show that calcite crystallized either in cm- to dm-scale melt pockets, or as an interstitial phase forming an interconnected network between dolomite grains. Calcite-dolomite thermometry yields a temperature of at least 670 °C, which is well above the minimum melting temperature of ∼600 °C reported for the CaO-MgO-CO2-H2O system. Rare-earth element (REE) partition coefficients (KDcc/do) range between 9-35 for adjacent calcite-dolomite pairs. These KD values are 3-10 times higher than equilibrium values between dolomite and calcite reported in the literature. They suggest partitioning of incompatible elements into a melt phase. The δ18O and δ13C isotopic values of calcite and dolomite support this interpretation. Crystallographic orientations measured by electron backscattered diffraction (EBSD) show a clustering of c-axes for dolomite and interstitial calcite normal to the foliation plane, a typical feature for compressional deformation, whereas calcite crystallized in pockets shows a strong clustering of c-axes parallel to the pocket walls, suggesting that it crystallized after deformation had stopped. All this together suggests the formation of partial melts in these carbonates. A Schreinemaker analysis of the experimental data for a CO2-H2O fluid-saturated system indeed predicts formation of calcite-rich melt between 650-880 °C, in

  2. Improved quantum state transfer via quantum partially collapsing measurements

    NASA Astrophysics Data System (ADS)

    Man, Zhong-Xiao; Ba An, Nguyen; Xia, Yun-Jie

    2014-10-01

    In this work, we present a general scheme to improve quantum state transfer (QST) by taking advantage of quantum partially collapsing measurements. The scheme consists of a weak measurement performed at the initial time on the qubit encoding the state of concern and a subsequent quantum reversal measurement at a desired time on the destined qubit. We determine the strength qr of the post quantum reversal measurement as a function of the strength p of the prior weak measurement and the evolution time t so that near-perfect QST can be achieved by choosing p close enough to 1, with a finite success probability, regardless of the evolution time and the distance over which the QST takes place. The merit of our scheme is twofold: it not only improves QST, but also suppresses the energy dissipation, if any.

  3. On the Partially Reacted Boundary Layer in Rate Sticks

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda

    2013-06-01

    Using our reactive flow model TDRR to simulate detonation in a rate stick, we observe that a partially reacted layer (PRL) is formed near the boundary. We are not aware that such a PRL has been observed in tests, and this is why we regarded it in the past as a numerical artifact. Assuming that such an artifact may be caused by the finite rise time of the detonation shock, we showed in how it can be eliminated by delaying the outward boundary motion for a length of time comparable with the shock rise time. Here we revisit the PRL problem. First we show that it is not a numerical artifact but a real phenomenon. We do this by repeating the reactive flow run with a finer resolution. By looking at the PRL structure, we see doubling the resolution affects the PRL only slightly. We then conjecture that the PRL formation has to do with the finite duration of the reaction process (or the finite extent of the reaction zone). By the time the boundary rarefaction reaches a cell near the boundary, it is only partially reacted, and its reaction is cut off. To strengthen our conjecture we also show how the PRL structure changes with the reaction duration.

  4. On the partially reacted boundary layer in rate sticks

    NASA Astrophysics Data System (ADS)

    Partom, Y.

    2014-05-01

    Using our temperature dependent reactive flow model (TDRR) to simulate detonation in a rate stick, we observe that a partially reacted layer (PRL) is formed near the boundary. We are not aware that such a PRL has been observed in tests, and this is why we regarded it in the past as a numerical artifact. Assuming that such an artefact may be caused by the finite rise time of the detonation shock, we showed in [1] how it can be eliminated by delaying the outward boundary motion for a length of time comparable with the shock rise time. Here we revisit the PRL problem. We first show that it is not a numerical artifact but a real phenomenon. We do this by repeating the reactive flow run with a finer mesh. By looking at the PRL structure, we see that doubling the resolution affects the PRL only slightly. We then conjecture that the PRL formation has to do with the finite duration of the reaction process (or the finite extent of the reaction zone). By the time the boundary rarefaction reaches a cell near the boundary, it may be only partially reacted, and its reaction may therefore be cut off. To establish our conjecture we show how the PRL structure changes with the reaction duration.

  5. Conservation Development in the Partially Sighted Child.

    ERIC Educational Resources Information Center

    Swanson, Lee; And Others

    1979-01-01

    A comparative study of conservation development in partially sighted, sighted, and sighted blindfolded children at four age levels was assessed. Conservation on tasks of mass, weight, and volume were evaluated using Piaget and Inhelder's prediction, judgment, and explanation questions. The significant differences were found between groups, task,…

  6. Absolute partial photoionization cross sections of ozone.

    SciTech Connect

    Berkowitz, J.; Chemistry

    2008-04-01

    Despite the current concerns about ozone, absolute partial photoionization cross sections for this molecule in the vacuum ultraviolet (valence) region have been unavailable. By eclectic re-evaluation of old/new data and plausible assumptions, such cross sections have been assembled to fill this void.

  7. Partial Hospitalization Programs: A Current Perspective.

    ERIC Educational Resources Information Center

    Whitelaw, Carolyn A.; Perez, Edgardo L.

    1987-01-01

    Reviews the historical background, standards, the issue of day treatment versus day care, functional issues, specialization, efficacy and cost effectiveness, utilization issues, and alternative models of care of partial hospitalization programs in North America. Emphasizes issues of relevance when planning alternative programs to inpatient…

  8. Partially Correct Constructs Illuminate Students' Inconsistent Answers

    ERIC Educational Resources Information Center

    Ron, Gila; Dreyfus, Tommy; Hershkowitz, Rina

    2010-01-01

    We present a view of knowledge construction processes, focusing on partially correct constructs. Motivated by unexpected and seemingly inconsistent quantitative data based on the written reports of students working on an elementary probability task, we analyze in detail the knowledge construction processes of a representative student. We show how…

  9. Partial intravenous anesthesia in cats and dogs.

    PubMed

    Duke, Tanya

    2013-03-01

    The partial intravenous anesthesia technique (PIVA) is used to lower the inspired concentration of an inhalational anesthetic by concurrent use of injectable drugs. This technique reduces the incidence of undesirable side-effects and provides superior quality of anesthesia and analgesia. Drugs commonly used for PIVA include opioids, alpha-2 adrenergic agonists, injectable anesthetic agents, and lidocaine. Most are administered by intravenous infusion.

  10. Partial face recognition: alignment-free approach.

    PubMed

    Liao, Shengcai; Jain, Anil K; Li, Stan Z

    2013-05-01

    Numerous methods have been developed for holistic face recognition with impressive performance. However, few studies have tackled how to recognize an arbitrary patch of a face image. Partial faces frequently appear in unconstrained scenarios, with images captured by surveillance cameras or handheld devices (e.g., mobile phones) in particular. In this paper, we propose a general partial face recognition approach that does not require face alignment by eye coordinates or any other fiducial points. We develop an alignment-free face representation method based on Multi-Keypoint Descriptors (MKD), where the descriptor size of a face is determined by the actual content of the image. In this way, any probe face image, holistic or partial, can be sparsely represented by a large dictionary of gallery descriptors. A new keypoint descriptor called Gabor Ternary Pattern (GTP) is also developed for robust and discriminative face recognition. Experimental results are reported on four public domain face databases (FRGCv2.0, AR, LFW, and PubFig) under both the open-set identification and verification scenarios. Comparisons with two leading commercial face recognition SDKs (PittPatt and FaceVACS) and two baseline algorithms (PCA+LDA and LBP) show that the proposed method, overall, is superior in recognizing both holistic and partial faces without requiring alignment.

  11. A Partial Theory of Executive Succession.

    ERIC Educational Resources Information Center

    Thiemann, Francis C.

    This study has two purposes: (1) To construct a partial theory of succession, and (2) to utilize a method of theory construction which combines some of the concepts of Hans Zetterberg with the principles of formal symbolic logic. A bibliography on succession in complex organizations with entries on descriptive and empirical studies from various…

  12. Dopamine receptor partial agonists and addiction.

    PubMed

    Moreira, Fabricio A; Dalley, Jeffrey W

    2015-04-01

    Many drugs abused by humans acutely facilitate, either directly or indirectly, dopamine neurotransmission in the mesolimbic pathway. As a consequence dopamine receptor agonists and antagonists have been widely investigated as putative pharmacological therapies for addiction. This general strategy, however, has had only limited success due in part to poor treatment adherence and efficacy and the significant adverse effects of dopaminergic medications. In this perspective, we discuss the potential therapeutic use of dopamine receptor partial agonists in addiction, developed initially as antipsychotic agents. Recent research indicates that the dopamine D2 receptor partial agonists, such as aripiprazole, also shows useful ancillary efficacy in several animal models of psychostimulant and opioid addiction. Notably, these findings suggest that unlike full dopamine receptor agonists and antagonists these compounds have low abuse liability and are generally well tolerated. Indeed, partial dopamine agonists attenuate the rewarding properties of opioids without interfering with their analgesic effects. Herein we discuss the utility and potential of dopamine receptor partial agonists as treatments for both stimulant and non-stimulant drug addiction.

  13. PARTIALLY SEEING PROGRAM, 1966-1967.

    ERIC Educational Resources Information Center

    Lake County Special Education District, Gurnee, IL.

    THIS ADMINISTRATIVE OUTLINE OF THE PARTIALLY SEEING PROGRAM IN LAKE COUNTY, ILLINOIS, PRESENTS THE DUTIES AND RESPONSIBILITIES OF THE TWO ITINERANT TEACHERS AND THEIR IMMEDIATE SUPERVISORS. THE PROGRAM'S PHILOSOPHY, GOALS, HISTORY AND PLACEMENT IN THE COUNTY'S ORGANIZATIONAL STRUCTURE IS PRESENTED. THE ITINERANT TEACHER'S ADMINISTRATIVE…

  14. Partial Automated Alignment and Integration System

    NASA Technical Reports Server (NTRS)

    Kelley, Gary Wayne (Inventor)

    2014-01-01

    The present invention is a Partial Automated Alignment and Integration System (PAAIS) used to automate the alignment and integration of space vehicle components. A PAAIS includes ground support apparatuses, a track assembly with a plurality of energy-emitting components and an energy-receiving component containing a plurality of energy-receiving surfaces. Communication components and processors allow communication and feedback through PAAIS.

  15. Partially Decentralized Control Architectures for Satellite Formations

    NASA Technical Reports Server (NTRS)

    Carpenter, J. Russell; Bauer, Frank H.

    2002-01-01

    In a partially decentralized control architecture, more than one but less than all nodes have supervisory capability. This paper describes an approach to choosing the number of supervisors in such au architecture, based on a reliability vs. cost trade. It also considers the implications of these results for the design of navigation systems for satellite formations that could be controlled with a partially decentralized architecture. Using an assumed cost model, analytic and simulation-based results indicate that it may be cheaper to achieve a given overall system reliability with a partially decentralized architecture containing only a few supervisors, than with either fully decentralized or purely centralized architectures. Nominally, the subset of supervisors may act as centralized estimation and control nodes for corresponding subsets of the remaining subordinate nodes, and act as decentralized estimation and control peers with respect to each other. However, in the context of partially decentralized satellite formation control, the absolute positions and velocities of each spacecraft are unique, so that correlations which make estimates using only local information suboptimal only occur through common biases and process noise. Covariance and monte-carlo analysis of a simplified system show that this lack of correlation may allow simplification of the local estimators while preserving the global optimality of the maneuvers commanded by the supervisors.

  16. 31 CFR 315.41 - Partial redemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Partial redemption. 315.41 Section 315.41 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL..., SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES General Provisions for Payment §...

  17. Some Considerations on the Partial Credit Model

    ERIC Educational Resources Information Center

    Verhelst, N. D.; Verstralen, H. H. F. M.

    2008-01-01

    The Partial Credit Model (PCM) is sometimes interpreted as a model for stepwise solution of polytomously scored items, where the item parameters are interpreted as difficulties of the steps. It is argued that this interpretation is not justified. A model for stepwise solution is discussed. It is shown that the PCM is suited to model sums of binary…

  18. Canonical coordinates for partial differential equations

    NASA Technical Reports Server (NTRS)

    Hunt, L. R.; Villarreal, Ramiro

    1988-01-01

    Necessary and sufficient conditions are found under which operators of the form Sigma (m, j=1) x (2) sub j + X sub O can be made constant coefficient. In addition, necessary and sufficient conditions are derived which classify those linear partial differential operators that can be moved to the Kolmogorov type.

  19. Canonical coordinates for partial differential equations

    NASA Technical Reports Server (NTRS)

    Hunt, L. R.; Villarreal, Ramiro

    1987-01-01

    Necessary and sufficient conditions are found under which operators of the form Sigma(m, j=1) X(2)sub j + X sub 0 can be made constant coefficient. In addition, necessary and sufficient conditions are derived which classify those linear partial differential operators that can be moved to the Kolmogorov type.

  20. Some Partial Models for Urban Problems.

    ERIC Educational Resources Information Center

    Guthrie, Harold W.

    This paper focuses on partial models for solving urban problems to contrast our achievements as social scientists with our aspirations as prescribers of public policy. The objectives of this paper are (1) to review some of the reasons that an ideal set of solutions for urban problems has not been produced by social scientists and (2) to describe…

  1. Accommodating blind and partially sighted clients

    PubMed Central

    England, Gary; Gebbels, Tim; Whelan, Chantelle; Freeman, Sarah

    2014-01-01

    Veterinary surgeons provide an important service to blind and partially sighted guide dog owners. By adopting basic disability awareness and visual impairment training, practices can ensure that the assistance needs of those clients are met, facilitating access to veterinary care. PMID:25642013

  2. 24 CFR 203.371 - Partial claim.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES SINGLE FAMILY MORTGAGE INSURANCE Contract Rights and Obligations Claim Procedure § 203.371 Partial claim. (a... not exceeded the equivalent of 12 monthly mortgage payments; (3) The mortgagor is able to...

  3. 44 CFR 295.6 - Partial payments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Partial payments. 295.6 Section 295.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY CERRO GRANDE FIRE ASSISTANCE CERRO GRANDE FIRE ASSISTANCE General § 295.6...

  4. 44 CFR 295.6 - Partial payments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Partial payments. 295.6 Section 295.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY CERRO GRANDE FIRE ASSISTANCE CERRO GRANDE FIRE ASSISTANCE General § 295.6...

  5. Headborne illuminator for the partially sighted.

    PubMed

    Goodlaw, E I; Genensky, S M

    1978-12-01

    An inexpensive, headborne device is described that provides a bright spot of light on reading material even when the material is brought within 1 or 2 cm of the viewing eye. This aid has been used with great success by one of the authors for about 2 yr. This illuminator, or modifications of it, should prove valuable to other partially sighted people.

  6. 32 CFR 751.13 - Partial payments.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... can demonstrate a need for immediate funds to replace some of those items (e.g., food, clothes, baby... shall be taken to ensure the amount of the partial payment is deducted from the adjudicated value of the... payments are to be subtracted from the adjudicated value of the claim before payment of the balance...

  7. Partial face recognition: alignment-free approach.

    PubMed

    Liao, Shengcai; Jain, Anil K; Li, Stan Z

    2013-05-01

    Numerous methods have been developed for holistic face recognition with impressive performance. However, few studies have tackled how to recognize an arbitrary patch of a face image. Partial faces frequently appear in unconstrained scenarios, with images captured by surveillance cameras or handheld devices (e.g., mobile phones) in particular. In this paper, we propose a general partial face recognition approach that does not require face alignment by eye coordinates or any other fiducial points. We develop an alignment-free face representation method based on Multi-Keypoint Descriptors (MKD), where the descriptor size of a face is determined by the actual content of the image. In this way, any probe face image, holistic or partial, can be sparsely represented by a large dictionary of gallery descriptors. A new keypoint descriptor called Gabor Ternary Pattern (GTP) is also developed for robust and discriminative face recognition. Experimental results are reported on four public domain face databases (FRGCv2.0, AR, LFW, and PubFig) under both the open-set identification and verification scenarios. Comparisons with two leading commercial face recognition SDKs (PittPatt and FaceVACS) and two baseline algorithms (PCA+LDA and LBP) show that the proposed method, overall, is superior in recognizing both holistic and partial faces without requiring alignment. PMID:23520259

  8. ALFVEN WAVES IN A PARTIALLY IONIZED TWO-FLUID PLASMA

    SciTech Connect

    Soler, R.; Ballester, J. L.; Terradas, J.; Carbonell, M. E-mail: joseluis.ballester@uib.es E-mail: marc.carbonell@uib.es

    2013-04-20

    Alfven waves are a particular class of magnetohydrodynamic waves relevant in many astrophysical and laboratory plasmas. In partially ionized plasmas the dynamics of Alfven waves is affected by the interaction between ionized and neutral species. Here we study Alfven waves in a partially ionized plasma from the theoretical point of view using the two-fluid description. We consider that the plasma is composed of an ion-electron fluid and a neutral fluid, which interact by means of particle collisions. To keep our investigation as general as possible, we take the neutral-ion collision frequency and the ionization degree as free parameters. First, we perform a normal mode analysis. We find the modification due to neutral-ion collisions of the wave frequencies and study the temporal and spatial attenuation of the waves. In addition, we discuss the presence of cutoff values of the wavelength that constrain the existence of oscillatory standing waves in weakly ionized plasmas. Later, we go beyond the normal mode approach and solve the initial-value problem in order to study the time-dependent evolution of the wave perturbations in the two fluids. An application to Alfven waves in the low solar atmospheric plasma is performed and the implication of partial ionization for the energy flux is discussed.

  9. Partial colpocleisis for the treatment of sacrocolpopexy mesh erosions.

    PubMed

    Quiroz, Lieschen H; Gutman, Robert E; Fagan, Matthew J; Cundiff, Geoffrey W

    2008-02-01

    The purpose of this study is to describe the outcomes of partial colpocleisis for mesh erosions after sacrocolpopexy. We retrospectively report our surgical management of mesh erosion after sacrocolpopexy. Between 1998 and 2006, we performed 499 sacral colpopexies and treated 21 patients for mesh erosion, including three referrals. Mean (range) time to diagnosis was 10.3 months (1-49). Grafts materials included: Mersilene (13), Prolene (7), and Pelvicol (1). Surgical outcomes were available for 19 patients. Ten (48%) patients were cured by the initial partial colpocleisis, while nine (45%) required a second or third (2, 10%) vaginal operation. All of the second and third vaginal excisions failed. Eight patients had an abdominal excision, and two patients required a second abdominal procedure. The success rate for the first and second abdominal resections was 38% (3/8) and 100% (2/2). Abdominal surgeries had higher blood loss (84 vs 378 cc, p = 0.012) longer hospitalization (outpatient vs 4.2 days p = 0.001), and additional morbidity (18.6%). Potential contributing factors to surgical failure were the presence of Actinomyces and current smoking. We recommend initial transvaginal mesh resection with partial colpocleisis for synthetic mesh erosions after sacrocolpopexy. Vaginal failures may be better served by an abdominal excision. Potential contributors to failure include current smoking and the presence of Actinomyces.

  10. Reconsidering harmonic and anharmonic coherent states: Partial differential equations approach

    SciTech Connect

    Toutounji, Mohamad

    2015-02-15

    This article presents a new approach to dealing with time dependent quantities such as autocorrelation function of harmonic and anharmonic systems using coherent states and partial differential equations. The approach that is normally used to evaluate dynamical quantities involves formidable operator algebra. That operator algebra becomes insurmountable when employing Morse oscillator coherent states. This problem becomes even more complicated in case of Morse oscillator as it tends to exhibit divergent dynamics. This approach employs linear partial differential equations, some of which may be solved exactly and analytically, thereby avoiding the cumbersome noncommutative algebra required to manipulate coherent states of Morse oscillator. Additionally, the arising integrals while using the herein presented method feature stability and high numerical efficiency. The correctness, applicability, and utility of the above approach are tested by reproducing the partition and optical autocorrelation function of the harmonic oscillator. A closed-form expression for the equilibrium canonical partition function of the Morse oscillator is derived using its coherent states and partial differential equations. Also, a nonequilibrium autocorrelation function expression for weak electron–phonon coupling in condensed systems is derived for displaced Morse oscillator in electronic state. Finally, the utility of the method is demonstrated through further simplifying the Morse oscillator partition function or autocorrelation function expressions reported by other researchers in unevaluated form of second-order derivative exponential. Comparison with exact dynamics shows identical results.

  11. Laparoscopic Partial Nephrectomy for Renal-Cell Carcinoma During Pregnancy

    PubMed Central

    Yuruk, Emrah; Ucpinar, Burak; Binbay, Zerrin; Colakerol, Aykut; Muslumanoglu, Ahmet Yaser

    2016-01-01

    Abstract Background: The incidence of renal-cell carcinoma (RCC) is low during pregnancy. There are different approaches for timing of surgery and treatment modalities for RCC in pregnant women in the literature. To our knowledge, this is the first laparoscopic partial nephrectomy case in a pregnant woman. Case Presentation: Herein, we present a 34-year-old woman with a renal mass at her 14th gestational week. She was admitted to our clinic after a right renal mass was incidentally diagnosed during routine antenatal ultrasonography. MRI revealed a completely endophytic tumor of 6 × 6.5 × 6.5 cm, located in the upper half of the right kidney. We performed laparoscopic partial nephrectomy in our patient and the postoperative course was uneventful. Conclusion: This is the first presented laparoscopic partial nephrectomy case in a pregnant patient. Nephron-sparing surgeries can be performed laparoscopically in appropriate sized renal tumors in suitable pregnant patients. PMID:27579405

  12. Reconsidering harmonic and anharmonic coherent states: Partial differential equations approach

    NASA Astrophysics Data System (ADS)

    Toutounji, Mohamad

    2015-02-01

    This article presents a new approach to dealing with time dependent quantities such as autocorrelation function of harmonic and anharmonic systems using coherent states and partial differential equations. The approach that is normally used to evaluate dynamical quantities involves formidable operator algebra. That operator algebra becomes insurmountable when employing Morse oscillator coherent states. This problem becomes even more complicated in case of Morse oscillator as it tends to exhibit divergent dynamics. This approach employs linear partial differential equations, some of which may be solved exactly and analytically, thereby avoiding the cumbersome noncommutative algebra required to manipulate coherent states of Morse oscillator. Additionally, the arising integrals while using the herein presented method feature stability and high numerical efficiency. The correctness, applicability, and utility of the above approach are tested by reproducing the partition and optical autocorrelation function of the harmonic oscillator. A closed-form expression for the equilibrium canonical partition function of the Morse oscillator is derived using its coherent states and partial differential equations. Also, a nonequilibrium autocorrelation function expression for weak electron-phonon coupling in condensed systems is derived for displaced Morse oscillator in electronic state. Finally, the utility of the method is demonstrated through further simplifying the Morse oscillator partition function or autocorrelation function expressions reported by other researchers in unevaluated form of second-order derivative exponential. Comparison with exact dynamics shows identical results.

  13. Consequences and Resolution of Lunar Lower Mantle Partial Melt

    NASA Astrophysics Data System (ADS)

    Fuqua, H.; Bremner, P. M.; Diamond, M. R.; Garapic, G.; Lock, S. J.; Mallik, A.; Nishikawa, Y.; Panovska, S.; Shahar, A.; Lognonne, P. H.; Panero, W. R.; Faul, U.; Panning, M. P.; Jimenez-Perez, H.; Schmerr, N. C.; Williams, Q. C.

    2014-12-01

    Existence of a partially molten layer at depth has been proposed to explain the lack of observed farside deep moonquakes, the observation of reflected phases from deep moonquakes, and the dissipation of tidal energy within the lunar interior. However, subsequent models explore the possibility that dissipation due to elevated temperatures alone can explain the observed dissipation factor (Q) and tidal love numbers. We have explored the hypothesis that high titanium melt compositions associated with lunar mantle overturn may sink to the base of the mantle, locally or regionally. We have performed forward calculations varying composition and thickness of layers to evaluate if a partially molten layer at the base of the mantle is well constrained by the observational data. Self-consistent physical parameters are calculated for each compositional model that are then compared against the observed data to determine a subset of permissible models. The data constraints considered by this study include bulk density, moment of inertia, real and imaginary parts of the Love numbers, seismic travel times, and electrical conductivity. Dynamic calculations using ASPECT have also been considered to determine the implications of early lunar mantle convection for the survivability of the partially molten layer. Finally, and as a perspective for a future NASA New Frontiers Geophysical Network, we present 1D synthetic seismograms calculated for each proposed structure of the Moon to investigate the future seismological resolution of these deep lunar structure features. This work was initiated at the CIDER 2014 program.

  14. Partial aphid resistance in lettuce negatively affects parasitoids.

    PubMed

    Lanteigne, Marie-Eve; Brodeur, Jacques; Jenni, Sylvie; Boivin, Guy

    2014-10-01

    This study investigated the effects of partial plant resistance on the lettuce aphid Nasonovia ribisnigri (Mosley) (Hemiptera: Aphididae), a major pest of cultivated lettuce (Lactuca sativa L.), and one of its parasitoids, Aphidius ervi Haliday (Hymenoptera: Braconidae). Aphids were reared on susceptible (L. sativa variety Estival; S) or partially resistant (Lactuca serriola L. PI 491093; PR) lettuce, and next parasitized by A. ervi females. Fitness proxies were measured for both aphids and parasitoids. Developmental time to adult stage took longer for alate and apterous aphids (an average of 3.5 and 1.5 additional days, respectively) on PR than on S lettuce, and fecundity of alate aphids reared on PR lettuce was reduced by 37.8% relative to those reared on S lettuce. Size (tibia length) and weight of aphids reared on PR lettuce were lower than for aphids reared on S lettuce from the third and second instar onward, respectively. Parasitism of aphids reared on PR plants resulted in lower parasitoid offspring emergence (-49.9%), lower adult female (-30.3%) and male (-27.5%) weight, smaller adult female (-17.5%) and male (-11.9%) size, and lower female fecundity (37.8% fewer eggs) than when parasitoids developed from aphids reared on S plants. Our results demonstrate that partial aphid resistance in lettuce negatively affects both the second and third trophic levels. Host plant resistance in cultivated lettuce may therefore create an ecological sink for aphid parasitoids. PMID:25197882

  15. Transport of engineered silver (Ag) nanoparticles through partially fractured sandstones.

    PubMed

    Neukum, Christoph; Braun, Anika; Azzam, Rafig

    2014-08-01

    Transport behavior and fate of engineered silver nanoparticles (AgNP) in the subsurface is of major interest concerning soil and groundwater protection in order to avoid groundwater contamination of vital resources. Sandstone aquifers are important groundwater resources which are frequently used for public water supply in many regions of the world. The objective of this study is to get a better understanding of AgNP transport behavior in partially fractured sandstones. We executed AgNP transport studies on partially fissured sandstone drilling cores in laboratory experiments. The AgNP concentration and AgNP size in the effluent were analyzed using flow field-flow fractionation mainly. We employed inverse mathematical models on the measured AgNP breakthrough curves to identify and quantify relevant transport processes. Physicochemical filtration, time-dependent blocking due to filling of favorable attachment sites and colloid-facilitated transport were identified as the major processes for AgNP mobility. Physicochemical filtration was found to depend on solute chemistry, mineralogy, pore size distribution and probably on physical and chemical heterogeneity. Compared to AgNP transport in undisturbed sandstone matrix reported in the literature, their mobility in partially fissured sandstone is enhanced probably due to larger void spaces and higher hydraulic conductivity.

  16. Partial aphid resistance in lettuce negatively affects parasitoids.

    PubMed

    Lanteigne, Marie-Eve; Brodeur, Jacques; Jenni, Sylvie; Boivin, Guy

    2014-10-01

    This study investigated the effects of partial plant resistance on the lettuce aphid Nasonovia ribisnigri (Mosley) (Hemiptera: Aphididae), a major pest of cultivated lettuce (Lactuca sativa L.), and one of its parasitoids, Aphidius ervi Haliday (Hymenoptera: Braconidae). Aphids were reared on susceptible (L. sativa variety Estival; S) or partially resistant (Lactuca serriola L. PI 491093; PR) lettuce, and next parasitized by A. ervi females. Fitness proxies were measured for both aphids and parasitoids. Developmental time to adult stage took longer for alate and apterous aphids (an average of 3.5 and 1.5 additional days, respectively) on PR than on S lettuce, and fecundity of alate aphids reared on PR lettuce was reduced by 37.8% relative to those reared on S lettuce. Size (tibia length) and weight of aphids reared on PR lettuce were lower than for aphids reared on S lettuce from the third and second instar onward, respectively. Parasitism of aphids reared on PR plants resulted in lower parasitoid offspring emergence (-49.9%), lower adult female (-30.3%) and male (-27.5%) weight, smaller adult female (-17.5%) and male (-11.9%) size, and lower female fecundity (37.8% fewer eggs) than when parasitoids developed from aphids reared on S plants. Our results demonstrate that partial aphid resistance in lettuce negatively affects both the second and third trophic levels. Host plant resistance in cultivated lettuce may therefore create an ecological sink for aphid parasitoids.

  17. Temporary Targeted Hemostasis to Facilitate Bloodless Partial Nephrectomy

    PubMed Central

    Harty, Niall J; Moinzadeh, Alireza; Flacke, Sebastian; Pettit, Jeffrey; Benn, James A.; Libertino, John A; Madras, Peter N

    2011-01-01

    Purpose Lumagel™, a non-toxic polymer may be administered intra-arterially under fluoroscopy to obtain a bloodless operative field during partial nephrectomy while maintaining normal circulation to uninvolved renal tissue. We extend previous robotic assisted techniques developed in the swine model to studies of laparoscopic and open partial nephrectomy conducted in pigs and calves, designed to encompass vessel diameters similar to those encountered in humans. Materials and Methods 10 Animals (7 pigs, 3 calves) underwent flow interruption to the kidney, 2 with cross-clamping of the main renal artery, the remaining with Lumagel. Other than the first pig and calf, all animals then underwent partial nephrectomy. Results and Conclusions Using Lumagel, targeted blood flow interruption was achieved while circulation to uninvolved renal tissue was maintained. Hemostasis lasted for 30 minutes or more. Surgical resection averaged 11 minutes (range 10–13) and 23.3 (range 9–40) in the open and laparoscopic groups, respectively. Estimated blood loss was negligible with the exception of two cases, one in which an error in angiographic assessment lead to an unoccluded vessel near the resection site and a second case where a guide wire was inadvertently passed through a vessel. Time to complete flow return as determined by direct visualization of the kidney and its corresponding angiogram averaged 7 and 2.5 minutes for Lumagel and arterial clamping, respectively. Lumagel provides reliable and reproducible intraluminal blood flow interruption and flow restoration in both main and segmental renal arteries. By providing blood free resection, techniques described may facilitate partial nephrectomy without global renal ischemia. PMID:22137714

  18. Female-biased obligate strategies in a partially migratory population.

    PubMed

    Fudickar, Adam M; Schmidt, Andreas; Hau, Michaela; Quetting, Michael; Partecke, Jesko

    2013-07-01

    Partial migration occurs when a breeding population consists of seasonal migrants and year-round residents. Although it is common among birds, the basis of individual movement decisions within partially migratory populations is still unresolved. Over 4 years, we used state of the art tracking techniques, a combination of geolocators and radio transmitters, to follow individual European blackbirds Turdus merula year round from a partially migratory population to determine individual strategies and departure and arrival dates. The individual-based tracking combined with measures of energetic and hormonal (corticosterone) state enabled us to distinguish between obligate and facultative migration and to test several classical hypotheses of partial migration: the 'Arrival Time'-, 'Dominance'- and 'Thermal Tolerance'-hypotheses. Two distinct periods of departures from the breeding grounds were observed during the study; one in early autumn, and another during the midst of winter. Although blackbirds that migrated in autumn were never observed overwintering within 300 km of the study site, four individuals that departed in the winter were observed within 40 km. Females were significantly more likely to migrate in autumn than males but there was no difference in the age or body size of migrants and non migrants in autumn. Just prior to autumn migration, migrants had higher fat scores than non migrants and tended to have higher concentrations of baseline corticosterone, but similar concentrations of triglycerides. Unlike autumn migrants, we found no difference between the tendencies of males versus females to depart in winter, nor did we find any difference in body size or age of individuals that departed in the winter. Autumn migration was sex biased and resembled obligate migration. Our results provide strong support for the 'Arrival Time' hypothesis for partial migration in the autumn. We found no clear support for the 'Dominance' or 'Thermal Tolerance' hypotheses. By

  19. SAGUARO: a finite-element computer program for partially saturated porous flow problems

    SciTech Connect

    Eaton, R.R.; Gartling, D.K.; Larson, D.E.

    1983-06-01

    SAGUARO is a finite element computer program designed to calculate two-dimensional flow of mass and energy through porous media. The media may be saturated or partially saturated. SAGUARO solves the parabolic time-dependent mass transport equation which accounts for the presence of partially saturated zones through the use of highly non-linear material characteristic curves. The energy equation accounts for the possibility of partially saturated regions by adjusting the thermal capacitances and thermal conductivities according to the volume fraction of water present in the local pores. Program capabilities, user instructions and a sample problem are presented in this manual.

  20. SAGUARO: A finite-element computer program for partially saturated porous flow problems

    NASA Astrophysics Data System (ADS)

    Easton, R. R.; Gartling, D. K.; Larson, D. E.

    1983-11-01

    SAGUARO is finite element computer program designed to calculate two-dimensional flow of mass and energy through porous media. The media may be saturated or partially saturated. SAGUARO solves the parabolic time-dependent mass transport equation which accounts for the presence of partially saturated zones through the use of highly non-linear material characteristic curves. The energy equation accounts for the possibility of partially saturated regions by adjusting the thermal capacitances and thermal conductivities according to the volume fraction of water present in the local pores. Program capabilities, user instructions and a sample problem are presented in this manual.

  1. New advances in the partial-reflection-drifts experiment using microprocessors

    NASA Technical Reports Server (NTRS)

    Ruggerio, R. L.; Bowhill, S. A.

    1982-01-01

    Improvements to the partial reflection drifts experiment are completed. The results of the improvements include real time processing and simultaneous measurements of the D region with coherent scatter. Preliminary results indicate a positive correlation between drift velocities calculated by both methods during a two day interval. The possibility now exists for extended observations between partial reflection and coherent scatter. In addition, preliminary measurements could be performed between partial reflection and meteor radar to complete a comparison of methods used to determine velocities in the D region.

  2. Hertzian contact damage in magnesia-partially-stabilized zirconia

    SciTech Connect

    Pajares, A.; Guiberteau, F.; Lawn, B.R.; Lathabai, S.

    1995-04-01

    Hertzian contact damage in magnesia-partially-stabilized is examined. Ceramographic techniques and emission reveal the damage patterns to be fundamentally different in the as-fired, peak-aged, and over-aged states. Indentation stress-strain curves show that the plasticity component of the contact deformation increases monotonically with aging time. Whereas the tetragonal-monoclinic transformation plays an important role in the peak-aged material, alternative deformation processes dominate in the other states: microcracking in as-fired, an monoclinic twinning in over-aged.

  3. Two types of quasiperiodic partial synchrony in oscillator ensembles.

    PubMed

    Rosenblum, Michael; Pikovsky, Arkady

    2015-07-01

    We analyze quasiperiodic partially synchronous states in an ensemble of Stuart-Landau oscillators with global nonlinear coupling. We reveal two types of such dynamics: in the first case the time-averaged frequencies of oscillators and of the mean field differ, while in the second case they are equal, but the motion of oscillators is additionally modulated. We describe transitions from the synchronous state to both types of quasiperiodic dynamics, and a transition between two different quasiperiodic states. We present an example of a bifurcation diagram, where we show the borderlines for all these transitions, as well as domain of bistability.

  4. Asymmetric hollow nanorod formation through a partial galvanic replacement reaction.

    PubMed

    Seo, Daeha; Song, Hyunjoon

    2009-12-30

    An asymmetric single hollow structure was generated from Ag-Au-Ag heterometal nanorods by a partial galvanic replacement reaction for the first time. The C(2)-symmetry breaking took place because of the random generation of a single pit on only one end of the silver domain at an early stage of the reaction. Careful control of the reaction kinetics could also yield a double-hollow structure on both ends of the silver domain. The resulting single- and double-hollow nanorods exhibited characteristic extinctions in the near-IR range.

  5. Active Chemical Sensing With Partially Observable Markov Decision Processes

    NASA Astrophysics Data System (ADS)

    Gosangi, Rakesh; Gutierrez-Osuna, Ricardo

    2009-05-01

    We present an active-perception strategy to optimize the temperature program of metal-oxide sensors in real time, as the sensor reacts with its environment. We model the problem as a partially observable Markov decision process (POMDP), where actions correspond to measurements at particular temperatures, and the agent is to find a temperature sequence that minimizes the Bayes risk. We validate the method on a binary classification problem with a simulated sensor. Our results show that the method provides a balance between classification rate and sensing costs.

  6. High temporal resolution functional MRI with partial separability model.

    PubMed

    Ngo, Giang-Chau; Holtrop, Joseph L; Fu, Maojing; Lam, Fan; Sutton, Bradley P

    2015-01-01

    Even though the hemodynamic response is a slow phenomenon, high temporal resolution in functional fMRI can enable better differentiation between the signal of interest and physiological noise or increase the statistical power of functional studies. To increase the temporal resolution, several methods have been developed to decrease the repetition time, TR, such as simultaneous multi-slice imaging and MR encephalography approaches. In this work, a method using a fast acquisition and a partial separability model is presented to achieve a multi-slice fMRI protocol at a temporal resolution of 75 ms. The method is demonstrated on a visual block task. PMID:26738022

  7. Partial splenic resection using the TA-stapler.

    PubMed

    Uranüs, S; Kronberger, L; Kraft-Kine, J

    1994-07-01

    Since 1987, we have used the TA-stapler for 15 partial resections of the spleen. The cases included 5 second- to third-degree traumatic ruptures, 4 splenic cysts, 3 injuries resulting from accidents during upper-abdominal surgery, 2 diagnostic resections, and 1 intralienal pancreatic cyst. The TA-55 stapler was used 14 times and the TA-90 once. No patient developed postoperative bleeding or required further surgery. Postoperative laboratory chemistry and scintigraphy findings were within the limits indicative of normal function in all cases. The TA-stapler expands the technical possibilities for organ-conserving splenic surgery.

  8. Partial Kernelization for Rank Aggregation: Theory and Experiments

    NASA Astrophysics Data System (ADS)

    Betzler, Nadja; Bredereck, Robert; Niedermeier, Rolf

    Rank Aggregation is important in many areas ranging from web search over databases to bioinformatics. The underlying decision problem Kemeny Score is NP-complete even in case of four input rankings to be aggregated into a "median ranking". We study efficient polynomial-time data reduction rules that allow us to find optimal median rankings. On the theoretical side, we improve a result for a "partial problem kernel" from quadratic to linear size. On the practical side, we provide encouraging experimental results with data based on web search and sport competitions, e.g., computing optimal median rankings for real-world instances with more than 100 candidates within milliseconds.

  9. 40 CFR Table 7 to Subpart Vvvvvv... - Partially Soluble HAP

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 15 2014-07-01 2014-07-01 false Partially Soluble HAP 7 Table 7 to... Pt. 63, Subpt. VVVVVV, Table 7 Table 7 to Subpart VVVVVV of Part 63—Partially Soluble HAP As required... partially soluble HAP listed in the following table. Partially soluble HAP name CAS No. 1....

  10. 40 CFR Table 7 to Subpart Vvvvvv... - Partially Soluble HAP

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 15 2013-07-01 2013-07-01 false Partially Soluble HAP 7 Table 7 to... Pt. 63, Subpt. VVVVVV, Table 7 Table 7 to Subpart VVVVVV of Part 63—Partially Soluble HAP As required... partially soluble HAP listed in the following table. Partially soluble HAP name CAS No. 1....

  11. 40 CFR Table 7 to Subpart Vvvvvv... - Partially Soluble HAP

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 15 2012-07-01 2012-07-01 false Partially Soluble HAP 7 Table 7 to... Pt. 63, Subpt. VVVVVV, Table 7 Table 7 to Subpart VVVVVV of Part 63—Partially Soluble HAP As required... partially soluble HAP listed in the following table. Partially soluble HAP name CAS No. 1....

  12. Bulk YBa2Cu3O(x) superconductors through pressurized partial melt growth processing

    NASA Technical Reports Server (NTRS)

    Hu, S.; Hojaji, H.; Barkatt, A.; Boroomand, M.; Hung, M.; Buechele, A. C.; Thorpe, A. N.; Davis, D. D.; Alterescu, S.

    1992-01-01

    A novel pressurized partial melt growth process has been developed for producing large pieces of bulk Y-Ba-Cu-O superconductors. During long-time partial melt growth stage, an additional driving force for solidification is obtained by using pressurized oxygen gas. The microstructure and superconducting properties of the resulting samples were investigated. It was found that this new technique can eliminate porosity and inhomogeneity, promote large-scale grain-texturing, and improve interdomain coupling as well.

  13. Run-and-tumble particles, telegrapher’s equation and absorption problems with partially reflecting boundaries

    NASA Astrophysics Data System (ADS)

    Angelani, Luca

    2015-12-01

    Absorption problems of run-and-tumble particles, described by the telegrapher's equation, are analyzed in one space dimension considering partially reflecting boundaries. Exact expressions for the probability distribution function in the Laplace domain and for the mean time to absorption are given, discussing some interesting limits (Brownian and wave limit, large volume limit) and different case studies (semi-infinite segment, equal and symmetric boundaries, totally/partially reflecting boundaries).

  14. Retinal pigment epithelial change and partial lipodystrophy.

    PubMed Central

    Davis, T. M.; Holdright, D. R.; Schulenberg, W. E.; Turner, R. C.; Joplin, G. F.

    1988-01-01

    Cuticular drusen and retinal pigment epithelial changes were found incidentally in a 27 year old Lebanese woman during assessment of partial lipodystrophy. Her vision was normal despite involvement of both maculae. The patient had hypocomplementaemia, but serum C3 nephritic factor was absent and renal function was normal. She had impaired glucose tolerance and a continuous infusion of glucose with model assessment (CIGMA) test revealed low normal tissue insulin sensitivity and high normal pancreatic beta cell function. Mild fasting hypertriglyceridaemia (2.0 mmol/l) may have been secondary to impaired insulin sensitivity. Endocrine function was otherwise normal apart from a completely absent growth hormone response to adequate hypoglycaemia. The simultaneous occurrence of partial lipodystrophy and retinal pigmentary epithelial and basement membrane changes appears to be a newly recognized syndrome. Images Figure 1 Figure 2 PMID:3255937

  15. Wear mechanisms of partially stabilized zirconia

    SciTech Connect

    Aronov, V.

    1987-01-01

    This paper is devoted to an investigation of the wear mechanisms of magnesia and yttria partially-stabilized zirconia in ceramic/ceramic and ceramic/metal sliding-contact tribological systems at high temperature. It was found that the wear of ceramics rubbed against ceramics at room temperature may be attributed to intensive plastic deformation of surfaces resulting in low cycle fatigue. The wear mechanism of ceramics rubbed against metals was by polishing and surface fracture, while that of metals was adhesive transfer of material on to ceramic surfaces. Investigation of the wear behavior of magnesia partially-stabilized zirconia rubbed against itself showed that up to three orders of magnitude increase in wear resistance can be achieved in a particular temperature range, depending on both sliding speed and the ambient temperature. XRD analysis revealed that a thermally-induced phase transformation takes place on the frictional interface.

  16. Multiple teleportation via partially entangled GHZ state

    NASA Astrophysics Data System (ADS)

    Xiong, Pei-Ying; Yu, Xu-Tao; Zhan, Hai-Tao; Zhang, Zai-Chen

    2016-08-01

    Quantum teleportation is important for quantum communication. We propose a protocol that uses a partially entangled Greenberger-Horne-Zeilinger (GHZ) state for single hop teleportation. Quantum teleportation will succeed if the sender makes a Bell state measurement, and the receiver performs the Hadamard gate operation, applies appropriate Pauli operators, introduces an auxiliary particle, and applies the corresponding unitary matrix to recover the transmitted state.We also present a protocol to realize multiple teleportation of partially entangled GHZ state without an auxiliary particle. We show that the success probability of the teleportation is always 0 when the number of teleportations is odd. In order to improve the success probability of a multihop, we introduce the method used in our single hop teleportation, thus proposing a multiple teleportation protocol using auxiliary particles and a unitary matrix. The final success probability is shown to be improved significantly for the method without auxiliary particles for both an odd or even number of teleportations.

  17. Partial peritoneal alimentation in an infant.

    PubMed

    Merritt, R J; Atkinson, J B; Whalen, T V; Thomas, D W; Sinatra, F R; Roloson, G J

    1988-01-01

    We provided partial peritoneal alimentation to a 1.69-kg 11-month-old premature infant who had no available central venous access, depleted peripheral venous access, and gastrointestinal dysfunction. A cuffed silastic catheter was surgically inserted into the suprahepatic space. An alimentation solution was continuously infused into the peritoneum for 28 days to supplement peripheral venous and nasogastric alimentation and contributed 42 +/- 15% of total calories daily. Weight gain was achieved, but complications included hypoglycemia, hypophosphatemia, intravascular dehydration, catheter site leakage, ascites, and hydrocele. At autopsy 11 months later, lipid accumulation was present in the upper peritoneum and the hilar regions of the lungs secondary to preexisting lymphatic obstruction. Partial peritoneal alimentation may be feasible when other access routes are inadequate, but lymphatic obstruction is a contraindication to the peritoneal administration of lipid emulsions.

  18. The Lockheed alternate partial polarizer universal filter

    NASA Technical Reports Server (NTRS)

    Title, A. M.

    1976-01-01

    A tunable birefringent filter using an alternate partial polarizer design has been built. The filter has a transmission of 38% in polarized light. Its full width at half maximum is .09A at 5500A. It is tunable from 4500 to 8500A by means of stepping motor actuated rotating half wave plates and polarizers. Wave length commands and thermal compensation commands are generated by a PPD 11/10 minicomputer. The alternate partial polarizer universal filter is compared with the universal birefringent filter and the design techniques, construction methods, and filter performance are discussed in some detail. Based on the experience of this filter some conclusions regarding the future of birefringent filters are elaborated.

  19. Applications of partially quenched chiral perturbation theory

    SciTech Connect

    Golterman, M.F.; Leung, K.C.

    1998-05-01

    Partially quenched theories are theories in which the valence- and sea-quark masses are different. In this paper we calculate the nonanalytic one-loop corrections of some physical quantities: the chiral condensate, weak decay constants, Goldstone boson masses, B{sub K}, and the K{sup +}{r_arrow}{pi}{sup +}{pi}{sup 0} decay amplitude, using partially quenched chiral perturbation theory. Our results for weak decay constants and masses agree with, and generalize, results of previous work by Sharpe. We compare B{sub K} and the K{sup +} decay amplitude with their real-world values in some examples. For the latter quantity, two other systematic effects that plague lattice computations, namely, finite-volume effects and unphysical values of the quark masses and pion external momenta, are also considered. We find that typical one-loop corrections can be substantial. {copyright} {ital 1998} {ital The American Physical Society}

  20. Transient myeloproliferative disorder with partial trisomy 21.

    PubMed

    Takahashi, Takahide; Inoue, Akira; Yoshimoto, Junko; Kanamitsu, Kiichiro; Taki, Tomohiko; Imada, Masahide; Yamada, Mutsuko; Ninomiya, Shinsuke; Toki, Tsutomu; Terui, Kiminori; Ito, Etsuro; Shimada, Akira

    2015-11-01

    Myeloid malignancy with Down syndrome (ML-DS) is estimated to have a step-wise leukemogenesis including GATA1 mutation. Trisomy 21 is essential for ML-DS; however, we do not know exactly which gene or genes located on chromosome 21 are necessary for the ML-DS. We report a female infant with transient myeloproliferative disorder (TMD) and partial trisomy 21. SNP array analysis showed 10 Mb amplification of 21q22.12-21q22.3, which included DYRK1A, ERG, and ETS but not the RUNX1 gene. With two other reported TMD cases having partial trisomy 21, DYRK1A, ERG, and ETS were the most likely genes involved in collaboration with the GATA1 mutation. PMID:26138905

  1. Deterministic dense coding with partially entangled states

    SciTech Connect

    Mozes, Shay; Reznik, Benni; Oppenheim, Jonathan

    2005-01-01

    The utilization of a d-level partially entangled state, shared by two parties wishing to communicate classical information without errors over a noiseless quantum channel, is discussed. We analytically construct deterministic dense coding schemes for certain classes of nonmaximally entangled states, and numerically obtain schemes in the general case. We study the dependency of the maximal alphabet size of such schemes on the partially entangled state shared by the two parties. Surprisingly, for d>2 it is possible to have deterministic dense coding with less than one ebit. In this case the number of alphabet letters that can be communicated by a single particle is between d and 2d. In general, we numerically find that the maximal alphabet size is any integer in the range [d,d{sup 2}] with the possible exception of d{sup 2}-1. We also find that states with less entanglement can have a greater deterministic communication capacity than other more entangled states.

  2. Partial Androgen Insensitivity Syndrome Presenting with Gynecomastia

    PubMed Central

    Lee, Sung Won; Kwak, Dong Shin; Jung, In Sub; Kwak, Joo Hee; Park, Jung Hwan; Hong, Sang Mo; Lee, Chang Bum; Park, Yong Soo; Kim, Dong Sun; Choi, Woong Hwan

    2015-01-01

    Gynecomastia is a benign enlargement of the male breast caused by the proliferation of glandular breast tissue. Determining the various causes of gynecomastia such as physiological causes, drugs, systemic diseases, and endocrine disorders is important. Androgen insensitivity syndrome (AIS) is a rare endocrine disorder presenting with gynecomastia and is a disorder of male sexual differentiation caused by mutations within the androgen receptor gene. All individuals with AIS have the 46 XY karyotype, although AIS phenotypes can be classified as mild, partial or complete and can differ among both males and females including ambiguous genitalia or infertility in males. We experienced a case of partial AIS presenting with gynecomastia and identified the androgen receptor gene mutation. PMID:25433660

  3. Optimal partial deterministic quantum teleportation of qubits

    SciTech Connect

    Mista, Ladislav Jr.; Filip, Radim

    2005-02-01

    We propose a protocol implementing optimal partial deterministic quantum teleportation for qubits. This is a teleportation scheme realizing deterministically an optimal 1{yields}2 asymmetric universal cloning where one imperfect copy of the input state emerges at the sender's station while the other copy emerges at receiver's possibly distant station. The optimality means that the fidelities of the copies saturate the asymmetric cloning inequality. The performance of the protocol relies on the partial deterministic nondemolition Bell measurement that allows us to continuously control the flow of information among the outgoing qubits. We also demonstrate that the measurement is optimal two-qubit operation in the sense of the trade-off between the state disturbance and the information gain.

  4. Partial Conservation of Seniority and Nuclear Isomerism

    SciTech Connect

    Van Isacker, P.; Heinze, S.

    2008-02-08

    We point out the possibility of the partial conservation of the seniority quantum number when most eigenstates are mixed in seniority but some remain pure. This situation occurs in nuclei for the g{sub 9/2} and h{sub 9/2} shells where it is at the origin of the existence of seniority isomers in the ruthenium and palladium isotopes. It also occurs for f bosons.

  5. Partial reinforcement in human biofeedback learning.

    PubMed

    Morley, S

    1979-09-01

    This paper reviews the evidence for the efficacy of partial reinforcement in producing resistance to extinction in human biofeedback experiments. The methodological criteria necessary to demonstrate such effects are discussed, as is the status of the analogy of reinforcement and information feedback. It is suggested that the problem of maintaining responding in the absence of feedback should be tackled empirically rather than assuming the validity of findings from other areas of learning theory.

  6. Lifted Partially Premixed Flames in Microgravity

    NASA Technical Reports Server (NTRS)

    Lock, Andrew J.; Ganguly, Ranjan; Puri, Ishwar K.; Aggarwal, Suesh K.; Hegde, Uday

    2004-01-01

    Lifted Double and Triple flames are established in the UIC-NASA Partially Premixed microgravity rig. The flames examined in this paper are established above a coannular burner because its axisymmetric geometry allows for future implementation of other non-intrusive optical diagnostic techniques easily. Both burner-attached stable flames and lifted flames are established at normal and microgravity conditions in the drop tower facility.

  7. Partial Dynamical Symmetry in Nuclear Systems

    SciTech Connect

    Escher, J E

    2003-06-02

    Partial dynamical symmetry (PDS) extends and complements the concepts of exact and dynamical symmetry. It allows one to remove undesired constraints from an algebraic theory, while preserving some of the useful aspects of a dynamical symmetry, and to study the effects of symmetry breaking in a controlled manner. An example of a PDS in an interacting fermion system is presented. The associated PDS Hamiltonians are closely related with a realistic quadrupole-quadrupole interaction and provide new insights into this important interaction.

  8. Nonphotosensitive video game-induced partial seizures.

    PubMed

    Takahashi, Y; Shigematsu, H; Kubota, H; Inoue, Y; Fujiwara, T; Yagi, K; Seino, M

    1995-08-01

    We report a 9-year-old boy with a ring 20 chromosome anomaly whose complex partial seizures (CPS), presumably of frontal lobe origin, were often induced by playing video games. Neither photosensitivity nor pattern sensitivity was observed. An intensive video-EEG investigation showed that video games as well as mental calculation elicited rhythmic runs of bilateral high-voltage slow waves, which eventually evolved into ictal discharges. This case suggests that higher brain functions can be involved in seizure induction.

  9. Pseudopotential Method for Higher Partial Wave Scattering

    SciTech Connect

    Idziaszek, Zbigniew; Calarco, Tommaso

    2006-01-13

    We present a zero-range pseudopotential applicable for all partial wave interactions between neutral atoms. For p and d waves, we derive effective pseudopotentials, which are useful for problems involving anisotropic external potentials. Finally, we consider two nontrivial applications of the p-wave pseudopotential: we solve analytically the problem of two interacting spin-polarized fermions confined in a harmonic trap, and we analyze the scattering of p-wave interacting particles in a quasi-two-dimensional system.

  10. Partial intravenous anesthesia in cats and dogs

    PubMed Central

    Duke, Tanya

    2013-01-01

    The partial intravenous anesthesia technique (PIVA) is used to lower the inspired concentration of an inhalational anesthetic by concurrent use of injectable drugs. This technique reduces the incidence of undesirable side-effects and provides superior quality of anesthesia and analgesia. Drugs commonly used for PIVA include opioids, alpha-2 adrenergic agonists, injectable anesthetic agents, and lidocaine. Most are administered by intravenous infusion. PMID:23997266

  11. Observability of discretized partial differential equations

    NASA Technical Reports Server (NTRS)

    Cohn, Stephen E.; Dee, Dick P.

    1988-01-01

    It is shown that complete observability of the discrete model used to assimilate data from a linear partial differential equation (PDE) system is necessary and sufficient for asymptotic stability of the data assimilation process. The observability theory for discrete systems is reviewed and applied to obtain simple observability tests for discretized constant-coefficient PDEs. Examples are used to show how numerical dispersion can result in discrete dynamics with multiple eigenvalues, thereby detracting from observability.

  12. Underdetermined systems of partial differential equations

    SciTech Connect

    Bender, Carl M.; Dunne, Gerald V.; Mead, Lawrence R.

    2000-09-01

    This paper examines underdetermined systems of partial differential equations in which the independent variables may be classical c-numbers or even quantum operators. One can view an underdetermined system as expressing the kinematic constraints on a set of dynamical variables that generate a Lie algebra. The arbitrariness in the general solution reflects the freedom to specify the dynamics of such a system. (c) 2000 American Institute of Physics.

  13. Class of positive partial transposition states

    SciTech Connect

    Chruscinski, Dariusz; Kossakowski, Andrzej

    2006-08-15

    We construct a class of quantum bipartite d(multiply-in-circle sign)d states which are positive under partial transposition (PPT states). This class is invariant under the maximal commutative subgroup of U(d) and contains as special cases many well-known examples of PPT states. States from our class provide criteria for testing the indecomposability of positive maps. Such maps are crucial for constructing entanglement witnesses.

  14. Electrochemical and partial oxidation of methane

    NASA Astrophysics Data System (ADS)

    Singh, Rahul

    2008-10-01

    negligible coke formation on the novel fabricated anode by electroless plating process. Hydrogen is an environmentally cleaner source of energy. The recent increase in the demand of hydrogen as fuel for all types of fuel cells and petroleum refining process has boosted the need of production of hydrogen. Methane, a major component of natural gas is the major feedstock for production of hydrogen. The route of partial oxidation of methane to produce syngas (CO + H2) offers significant advantages over commercialized steam reforming process for higher efficiency and lower energy requirements. Partial oxidation of methane was studied by pulsing O2 into a CH4 flow over Rh/Al2O3 in a sequence of in situ infrared (IR) cell and fixed bed reactor at 773 K. The results obtained from the sequence of an IR cell followed by a fixed bed reactor show that (i) adsorbed CO produced possesses a long residence time, indicating that adsorbed oxygen leading to the formation of CO is significantly different from those leading to CO2 and (ii) CO2 is not an intermediate species for the formation of CO. In situ IR of pulse reaction coupled with alternating reactor sequence is an effective approach to study the primary and secondary reactions as well as the nature of their adsorbed species. As reported earlier, hydrogen remains to be the most effective fuel for fuel cells, the production of high purity hydrogen from naturally available resources such as coal, petroleum, and natural gas requires a number of energy-intensive steps, making fuel cell processes for stationary electric power generation prohibitively uneconomic. Direct use of coal or coal gas as the feed is a promising approach for low cost electricity generation. Coal gas solid oxide fuel cell was studied by pyrolyzing Ohio #5 coal to coal gas and transporting to a Cu anode solid oxide fuel cell to generate power. The study of coal-gas solid oxide fuel cell is divided into two sections, i.e., (i) understanding the composition of coal gas by

  15. 75 FR 68093 - Partial Grant and Partial Denial of Clean Air Act Waiver Application Submitted by Growth Energy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-04

    ... Protection Agency Partial Grant and Partial Denial of Clean Air Act Waiver Application Submitted by Growth Energy To Increase the Allowable Ethanol Content of Gasoline to 15 Percent; Decision of the Administrator...; ] ENVIRONMENTAL PROTECTION AGENCY Partial Grant and Partial Denial of Clean Air Act Waiver Application...

  16. Viscous fingering with partial miscible fluids

    NASA Astrophysics Data System (ADS)

    Fu, Xiaojing; Cueto-Felgueroso, Luis; Juanes, Ruben

    2015-11-01

    When a less viscous fluid displaces a more viscous fluid, the contrast in viscosity destabilizes the interface between the two fluids, leading to the formation of fingers. Studies of viscous fingering have focused on fluids that are either fully miscible or perfectly immiscible. In practice, however, the miscibility of two fluids can change appreciably with temperature and pressure, and often falls into the case of partial miscibility, where two fluids have limited solubility in each other. Following our recent work for miscible (Jha et al., PRL 2011, 2013) and immiscible systems (Cueto-Felgueroso and Juanes, PRL 2012, JFM 2014), here we propose a phase-field model for fluid-fluid displacements in a Hele-Shaw cell, when the two fluids have limited (but nonzero) solubility in one another. Partial miscibility is characterized through the design of thermodynamic free energy of the two-fluid system. We elucidate the key dimensionless groups that control the behavior of the system. We present high-resolution numerical simulations of the model applied to the viscous fingering problem. On one hand, we demonstrate the effect of partial miscibility on the hydrodynamic instability. On the other, we elucidate the role of the degree of fingering on the rate of mutual fluid dissolution.

  17. Multichannel cochlear implants in partially ossified cochleas.

    PubMed

    Balkany, T; Gantz, B; Nadol, J B

    1988-01-01

    Deposition of bone within the fluid spaces of the cochlea is encountered commonly in cochlear implant candidates and previously has been considered a relative contraindication to the use of multichannel intracochlear electrodes. This contraindication has been based on possible mechanical difficulty with electrode insertion as well as uncertainty about the potential benefit of the multichannel device in the patient. Fifteen profoundly deaf patients with partial ossification of the basal turn of the cochlea received implants with long intracochlear electrodes (11, Nucleus; 1, University of California at San Francisco/Storz; and 3, Symbion/Inneraid). In 11 cases, ossification had been predicted preoperatively by computed tomographic scan. Electrodes were completely inserted in 14 patients, and partial insertion was accomplished in one patient. All patients currently are using their devices and nine of 12 postlingually deaf patients have achieved some degree of open-set speech discrimination. This series demonstrates that in experienced hands, insertion of long multichannel electrodes into partially ossified cochleas is possible and that results are similar to those achieved in patients who have nonossified cochleas. PMID:3140705

  18. Acute renal injury after partial hepatectomy

    PubMed Central

    Peres, Luis Alberto Batista; Bredt, Luis Cesar; Cipriani, Raphael Flavio Fachini

    2016-01-01

    Currently, partial hepatectomy is the treatment of choice for a wide variety of liver and biliary conditions. Among the possible complications of partial hepatectomy, acute kidney injury (AKI) should be considered as an important cause of increased morbidity and postoperative mortality. Difficulties in the data analysis related to postoperative AKI after liver resections are mainly due to the multiplicity of factors to be considered in the surgical patients, moreover, there is no consensus of the exact definition of AKI after liver resection in the literature, which hampers comparison and analysis of the scarce data published on the subject. Despite this multiplicity of risk factors for postoperative AKI after partial hepatectomy, there are main factors that clearly contribute to its occurrence. First factor relates to large blood losses with renal hypoperfusion during the operation, second factor relates to the occurrence of post-hepatectomy liver failure with consequent distributive circulatory changes and hepatorenal syndrome. Eventually, patients can have more than one factor contributing to post-operative AKI, and frequently these combinations of acute insults can be aggravated by sepsis or exposure to nephrotoxic drugs. PMID:27478539

  19. Partial-Vacuum-Gasketed Electrochemical Corrosion Cell

    NASA Technical Reports Server (NTRS)

    Bonifas, Andrew P.; Calle, Luz M.; Hintze, Paul E.

    2006-01-01

    An electrochemical cell for making corrosion measurements has been designed to prevent or reduce crevice corrosion, which is a common source of error in prior such cells. The present cell (see figure) includes an electrolyte reservoir with O-ring-edged opening at the bottom. In preparation for a test, the reservoir, while empty, is pressed down against a horizontal specimen surface to form an O-ring seal. A purge of air or other suitable gas is begun in the reservoir, and the pressure in the reservoir is regulated to maintain a partial vacuum. While maintaining the purge and partial vacuum, and without opening the interior of the reservoir to the atmosphere, the electrolyte is pumped into the reservoir. The reservoir is then slowly lifted a short distance off the specimen. The level of the partial vacuum is chosen such that the differential pressure is just sufficient to keep the electrolyte from flowing out of the reservoir through the small O-ring/specimen gap. Electrochemical measurements are then made. Because there is no gasket (and, hence, no crevice between the specimen and the gasket), crevice corrosion is unlikely to occur.

  20. Acute renal injury after partial hepatectomy.

    PubMed

    Peres, Luis Alberto Batista; Bredt, Luis Cesar; Cipriani, Raphael Flavio Fachini

    2016-07-28

    Currently, partial hepatectomy is the treatment of choice for a wide variety of liver and biliary conditions. Among the possible complications of partial hepatectomy, acute kidney injury (AKI) should be considered as an important cause of increased morbidity and postoperative mortality. Difficulties in the data analysis related to postoperative AKI after liver resections are mainly due to the multiplicity of factors to be considered in the surgical patients, moreover, there is no consensus of the exact definition of AKI after liver resection in the literature, which hampers comparison and analysis of the scarce data published on the subject. Despite this multiplicity of risk factors for postoperative AKI after partial hepatectomy, there are main factors that clearly contribute to its occurrence. First factor relates to large blood losses with renal hypoperfusion during the operation, second factor relates to the occurrence of post-hepatectomy liver failure with consequent distributive circulatory changes and hepatorenal syndrome. Eventually, patients can have more than one factor contributing to post-operative AKI, and frequently these combinations of acute insults can be aggravated by sepsis or exposure to nephrotoxic drugs. PMID:27478539

  1. Partially ordered sets in complex networks

    NASA Astrophysics Data System (ADS)

    Xuan, Qi; Du, Fang; Wu, Tie-Jun

    2010-05-01

    In this paper, a partial-order relation is defined among vertices of a network to describe which vertex is more important than another on its contribution to the connectivity of the network. A maximum linearly ordered subset of vertices is defined as a chain and the chains sharing the same end-vertex are grouped as a family. Through combining the same vertices appearing in different chains, a directed chain graph is obtained. Based on these definitions, a series of new network measurements, such as chain length distribution, family diversity distribution, as well as the centrality of families, are proposed. By studying the partially ordered sets in three kinds of real-world networks, many interesting results are revealed. For instance, the similar approximately power-law chain length distribution may be attributed to a chain-based positive feedback mechanism, i.e. new vertices prefer to participate in longer chains, which can be inferred by combining the notable preferential attachment rule with a well-ordered recommendation manner. Moreover, the relatively large average incoming degree of the chain graphs may indicate an efficient substitution mechanism in these networks. Most of the partially ordered set-based properties cannot be explained by the current well-known scale-free network models; therefore, we are required to propose more appropriate network models in the future.

  2. Full and Partial Cloaking in Electromagnetic Scattering

    NASA Astrophysics Data System (ADS)

    Deng, Youjun; Liu, Hongyu; Uhlmann, Gunther

    2016-08-01

    In this paper, we consider two regularized transformation-optics cloaking schemes for electromagnetic (EM) waves. Both schemes are based on the blowup construction with the generating sets being, respectively, a generic curve and a planar subset. We derive sharp asymptotic estimates in assessing the cloaking performances of the two constructions in terms of the regularization parameters and the geometries of the cloaking devices. The first construction yields an approximate full-cloak, whereas the second construction yields an approximate partial-cloak. Moreover, by incorporating properly chosen conducting layers, both cloaking constructions are capable of nearly cloaking arbitrary EM contents. This work complements the existing results in Ammari et al. (SIAM J Appl Math 73:2055-2076, 2013), Bao and Liu (SIAM J Appl Math 74:724-742, 2014), Bao et al. (J Math Pure Appl (9) 101:716-733, 2014) on approximate EM cloaks with the generating set being a singular point, and it also extends Deng et al. (On regularized full- and partial-cloaks in acoustic scat- tering. Preprint, arXiv:1502.01174, 2015), Li et al. (Commun Math Phys, 335:671-712, 2015) on regularized full and partial cloaks for acoustic waves governed by the Helmholtz system to the more challenging EM case governed by the full Maxwell system.

  3. Conformal Visualization for Partially-Immersive Platforms

    PubMed Central

    Petkov, Kaloian; Papadopoulos, Charilaos; Zhang, Min; Kaufman, Arie E.; Gu, Xianfeng

    2010-01-01

    Current immersive VR systems such as the CAVE provide an effective platform for the immersive exploration of large 3D data. A major limitation is that in most cases at least one display surface is missing due to space, access or cost constraints. This partially-immersive visualization results in a substantial loss of visual information that may be acceptable for some applications, however it becomes a major obstacle for critical tasks, such as the analysis of medical data. We propose a conformal deformation rendering pipeline for the visualization of datasets on partially-immersive platforms. The angle-preserving conformal mapping approach is used to map the 360°3D view volume to arbitrary display configurations. It has the desirable property of preserving shapes under distortion, which is important for identifying features, especially in medical data. The conformal mapping is used for rasterization, realtime raytracing and volume rendering of the datasets. Since the technique is applied during the rendering, we can construct stereoscopic images from the data, which is usually not true for image-based distortion approaches. We demonstrate the stereo conformal mapping rendering pipeline in the partially-immersive 5-wall Immersive Cabin (IC) for virtual colonoscopy and architectural review. PMID:26279083

  4. Partial entrainment of gravel bars during floods

    USGS Publications Warehouse

    Konrad, C.P.; Booth, D.B.; Burges, S.J.; Montgomery, D.R.

    2002-01-01

    Spatial patterns of bed material entrainment by floods were documented at seven gravel bars using arrays of metal washers (bed tags) placed in the streambed. The observed patterns were used to test a general stochastic model that bed material entrainment is a spatially independent, random process where the probability of entrainment is uniform over a gravel bar and a function of the peak dimensionless shear stress ??*0 of the flood. The fraction of tags missing from a gravel bar during a flood, or partial entrainment, had an approximately normal distribution with respect to ??*0 with a mean value (50% of the tags entrained) of 0.085 and standard deviation of 0.022 (root-mean-square error of 0.09). Variation in partial entrainment for a given ??*0 demonstrated the effects of flow conditioning on bed strength, with lower values of partial entrainment after intermediate magnitude floods (0.065 < ??*0 < 0.08) than after higher magnitude floods. Although the probability of bed material entrainment was approximately uniform over a gravel bar during individual floods and independent from flood to flood, regions of preferential stability and instability emerged at some bars over the course of a wet season. Deviations from spatially uniform and independent bed material entrainment were most pronounced for reaches with varied flow and in consecutive floods with small to intermediate magnitudes.

  5. Energy considerations in the partial space elevator

    NASA Astrophysics Data System (ADS)

    Woo, Pamela; Misra, Arun K.

    2014-06-01

    The space elevator has been proposed as an alternate method for space transportation. A partial elevator is composed of a tether of several hundreds of kilometres, held vertically in tension between two end masses, with its centre of orbit placed at the geosynchronous orbit. A spacecraft can dock at the lower end, and then use the climber on the elevator to ascend to higher altitudes. In this paper, energy calculations are performed, to determine whether a partial elevator can provide sufficient savings in operational costs, compared to the traditional rocket-powered launch. The energy required to launch a spacecraft from a Low Earth Orbit (LEO) to the geostationary orbit (GEO) is calculated for two trajectories. In the first trajectory, the spacecraft travels from LEO to GEO via a Hohmann transfer. In the second trajectory, the spacecraft travels from LEO to the lower end of the partial space elevator with a Hohmann transfer, and then uses the elevator to climb to GEO. The total energy required is compared between the two trajectories. The effects of tether length, spacecraft-to-climber mass ratio, altitude of LEO, and tether material are investigated.

  6. Effects of Astrophysical Magnetic Fields in Partially Ionized Gases

    NASA Astrophysics Data System (ADS)

    Arge, Charles Nickolos

    1997-11-01

    Magnetic field studies in astrophysics are usually carried out with the assumptions that (i) the plasma is fully ionized, and (ii) ideal MHD applies. These assumptions are justified in many astrophysical contexts. However, here, we focus on two environments composed of partially ionized gas, and where dissipation processes due to departures from complete ionization have significant effects. Using detailed numerical computations, we quantify these non-ideal MHD effects and compare them with astrophysical data. First we consider the structure of an MHD shock as it relates to the interaction between the heliosphere and the local interstellar medium (LISM). We ask: does the heliosphere generate a bow shock as it moves through the LISM? Since the LISM is only partially ionized, ion-atom interactions provide a dissipation mechanism which may smooth out an otherwise abrupt transition between the LISM and the heliospheric material. To investigate this possibility, we develop a two-fluid code that computes the structure of one-dimensional transverse MHD shock fronts. We find existence of extensive areas of permissible parameter space where ion-atom mediation is strong enough to smear out the bow shock over hundreds of AU. This is relevant to a recent interpretation of Hubble Space Telescope spectra suggesting that the heliospheric bow shock does not exist. Next, we study the two-dimensional behavior of partially ionized gas in magnetized regions of the solar atmosphere. The highly time-dependent nature of solar magnetic fields frequently produces interacting oppositely directed magnetic fields. Since in partially ionized gases the ions 'feel' the field more than the atoms, the gas which emerges from such interacting fields may have a different ion/atom ratio than the ambient medium. By extending the ZEUS-3D code to apply to a partially ionized gas, we have quantified this effect. Our simulations show that enhancements in ion/atom ratios may be as large as a factor of almost

  7. Liquid spreading under partial wetting conditions

    NASA Astrophysics Data System (ADS)

    Chen, M.; Pahlavan, A. A.; Cueto-Felgueroso, L.; McKinley, G. H.; Juanes, R.

    2013-12-01

    Traditional mathematical descriptions of multiphase flow in porous media rely on a multiphase extension of Darcy's law, and lead to nonlinear second-order (advection-diffusion) partial differential equations for fluid saturations. Here, we study horizontal redistribution of immiscible fluids. The traditional Darcy-flow model predicts that the spreading of a finite amount of liquid in a horizontal porous medium never stops; a prediction that is not substantiated by observation. To help guide the development of new models of multiphase flow in porous media [1], we draw an analogy with the flow of thin films. The flow of thin films over flat surfaces has been the subject of much theoretical, experimental and computational research [2]. Under the lubrication approximation, the classical mathematical model for these flows takes the form of a nonlinear fourth-order PDE, where the fourth-order term models the effect of surface tension [3]. This classical model, however, effectively assumes that the film is perfectly wetting to the substrate and, therefore, does not capture the partial wetting regime. Partial wetting is responsible for stopping the spread of a liquid puddle. Here, we present experiments of (large-volume) liquid spreading over a flat horizontal substrate in the partial wetting regime, and characterize the four spreading regimes that we observe. We extend our previous theoretical work of two-phase flow in a capillary tube [4], and develop a macroscopic phase-field modeling of thin-film flows with partial wetting. Our model naturally accounts for the dynamic contact angle at the contact line, and therefore permits modeling thin-film flows without invoking a precursor film, leading to compactly-supported solutions that reproduce the spreading dynamics and the static equilibrium configuration observed in the experiments. We anticipate that this modeling approach will provide a natural mathematical framework to describe spreading and redistribution of immiscible

  8. 5 CFR 831.631 - Post-retirement election of fully reduced annuity or partially reduced annuity to provide a...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., within 1 year after a post-retirement marriage, a fully reduced annuity or a partially reduced annuity to... partially reduced annuity at the time of retirement may elect, within 1 year after a postretirement marriage... month beginning 1 year after the date of the post-retirement marriage. (b) Except as provided...

  9. Partially Polyurethane-Covered Stent for Cerebral Aneurysm Treatment

    PubMed Central

    Rangwala, Hussain S.; Ionita, Ciprian N.; Rudin, Stephen; Baier, Robert E.

    2009-01-01

    Partially polyurethane-covered stent (PPCS) is proposed for the treatment of cerebral aneurysms. The PPCSs were observed to substantially modify the flow entering the aneurysm in a patient-specific aneurysm phantom (PSAP). These stents can act as flow modulators and the polyurethane (PU) membrane can provide a smooth scaffold for restoring the structural integrity of the diseased vessel. Partial coating of the stent aids in sealing only the entrance to the aneurysm while keeping the perforators around the aneurysm open and patent. Biocompatibility of the PU membrane was monitored using contact angle measurements to show that critical surface tension (CST) values remained in the thromboresistant range of 20–30 mN/m. Stent flexibility, stiffness, and pressure–diameter relationship showed no significant change after asymmetric PU film application. No delamination of the PU membrane from the stent was observed within the working strains of the stent. The flow modulating capability of the PPCS was monitored by intentionally orienting the stent to cover either the proximal or the distal regions along the neck of the PSAP. Time density curves (TDCs) compared the relative metrics of input rate, washout rate, residence time, and influx in the aneurysm before and after the stent placement. PMID:18837459

  10. Boundedness of weak solutions to evolutionary partial integro-differential equations with discontinuous coefficients

    NASA Astrophysics Data System (ADS)

    Zacher, Rico

    2008-12-01

    We investigate linear and quasilinear evolutionary partial integro-differential equations of second order which include time fractional evolution equations of time order less than one. By means of suitable energy estimates and De Giorgi's iteration technique we establish results asserting the global boundedness of appropriately defined weak solutions of these problems. We also show that a maximum principle holds for such equations.

  11. Interpreting coagulation assays.

    PubMed

    Green, David

    2010-09-01

    The interpretation of coagulation assays requires knowledge of the principal clotting pathways. The activated partial thromboplastin time is sensitive to all hemostatic factors except FVII, whereas the prothrombin time reflects levels of prothrombin and FV, FVII, and FX. Using the two tests in concert is helpful in identifying hemophilia, the coagulopathy of liver disease, and disseminated intravascular coagulation. In addition, the activated partial thromboplastin time and prothrombin time are used for monitoring anticoagulant therapy with heparin and warfarin, respectively. Measurement of D-dimer is informative in patients suspected of having thrombotic disorders and determining the risk of thrombosis recurrence. Mixing tests distinguish clotting factor deficiencies from circulating anticoagulants such as heparin, the lupus anticoagulant, and antibodies directed against specific clotting factors. The modified Bethesda assay detects and provides an indication of the strength of FVIII inhibitors. However, interpreting the results of coagulation assays is not always straightforward, and expert consultation is occasionally required to resolve difficult clinical situations. PMID:20855988

  12. Preoperative and postoperative hemostatic profiles of dogs undergoing ovariohysterectomy.

    PubMed

    Millis, D L; Hauptman, J G; Richter, M

    1992-10-01

    Hemostatic profiles were evaluated in 15 healthy dogs immediately before and 24 hours after celiotomy for routine ovariohysterectomy. Prothrombin time, activated partial thromboplastin time, fibrinogen, fibrin degradation products, antithrombin III activity, platelet count, and hemogram were measured. There were no significant changes in prothrombin time, activated partial thromboplastin time, fibrin degradation products, antithrombin III activity, or platelet count. Fibrinogen concentration was significantly higher following surgery. Postoperative leukocyte differential counts were typical of stress leukograms, and were characterized by leukocytosis, neutrophilia, lymphopenia and eosinopenia. Mild decreases in packed cell volume, red blood cell count and hemoglobin concentration were consistent with minor blood loss during surgery or fluid retention and hemodilution postoperatively. It was concluded that celiotomy and routine ovariohysterectomy in healthy dogs did not alter hemostatic profiles 24 hours after surgery. Abnormal postoperative hemostatic profiles should not be attributed to surgery alone; other causes of abnormal hemostatic profiles should be investigated.

  13. Equilibrium and Stability of Partial Toroidal Plasma Discharges

    SciTech Connect

    Oz, E.; Myers, C. E.; Yamada, M.; Ji, H.; Kulsrud, R.; Xie, J.

    2011-01-04

    The equilibrium and stability of partial toroidal flux ropes are studied in detail in the laboratory, motivated by ubiquitous loop structures on the solar surface. The flux ropes studied here are magnetized arc discharges formed in the Magnetic Reconnection Experiment (MRX). It is found that these loops robustly maintain their equilibrium on time scales much longer than the Alfven time over a wide range of plasma current, guide eld strength, and angle between electrodes, even in the absence of a strapping fi eld. Additionally, the external kink stability of these flux ropes is found to be governed by the Kruskal-Shafranov limit for a flux rope with line-tied boundary conditions at both ends (q > 1).

  14. Performance of Partially Fluorinated Polyimide Insulation for Aerospace Applications

    NASA Technical Reports Server (NTRS)

    Hammoud, Ahmad N.; Stavnes, Mark W.; Ide, James R.; Muegge, ED

    1995-01-01

    Polyimide has been used extensively as the primary wiring insulation in commercial planes, military aircraft, and space vehicles due to its low weight, high service temperature, and good dielectric strength. New failure modes, however, have been associated with the use of polyimide because of the susceptibility of the insulation to pyrolization and arc tracking. A new wiring construction utilizing partially fluorinated polyimide insulation has been tested and compared with the standard military polyimide wire. Electrical properties which were investigated include AC corona inception and extinction voltages (sea level and 60,000 feet), time/current to smoke, and wire fusing time. The two constructions were also characterized in terms of their mechanical properties including abrasion resistance, dynamic cut through, and notch propagation. These test efforts and the results obtained are presented and discussed.

  15. Robot-assisted laparoscopic partial nephrectomy during pregnancy.

    PubMed

    Park, Sung Yul; Ham, Won Sik; Jung, Hyun Jin; Jeong, Wooju; Kim, Won Tae; Rha, Koon Ho

    2008-09-01

    We present a case of a 36-year-old pregnant woman with renal cell carcinoma who underwent a successful robot-assisted laparoscopic partial nephrectomy (RLPN) at 14 weeks gestational age. The operative time, including da Vinci™ setup, was 165 min. The warm ischemic time was 28 min, and the estimated blood loss was 100 ml. The final pathologic evaluation was conventional-type renal cell carcinoma with Fuhrman nuclear grade 3, stage T1a disease with a negative margin. The remainder of the pregnancy was uneventful. Although previous cases of laparoscopic nephrectomy performed during pregnancy have been reported, this is the first case in which it has been performed using robotics. RLPN during pregnancy can be a safe and feasible alternative to open and laparoscopic surgery. PMID:27628260

  16. Gravity Effects Observed In Partially Premixed Flames

    NASA Technical Reports Server (NTRS)

    Puri, Ishwar K.; Aggarwal, Suresh K.; Lock, Andrew J.; Gauguly, Ranjan; Hegde, Uday

    2003-01-01

    Partially premixed flames (PPFs) contain a rich premixed fuel air mixture in a pocket or stream, and, for complete combustion to occur, they require the transport of oxidizer from an appropriately oxidizer-rich (or fuel-lean) mixture that is present in another pocket or stream. Partial oxidation reactions occur in fuel-rich portions of the mixture and any remaining unburned fuel and/or intermediate species are consumed in the oxidizer-rich portions. Partial premixing, therefore, represents that condition when the equivalence ratio (phi) in one portion of the flowfield is greater than unity, and in another section its value is less than unity. In general, for combustion to occur efficiently, the global equivalence ratio is in the range fuel-lean to stoichiometric. These flames can be established by design by placing a fuel-rich mixture in contact with a fuel-lean mixture, but they also occur otherwise in many practical systems, which include nonpremixed lifted flames, turbulent nonpremixed combustion, spray flames, and unwanted fires. Other practical applications of PPFs are reported elsewhere. Although extensive experimental studies have been conducted on premixed and nonpremixed flames under microgravity, there is a absence of previous experimental work on burner stabilized PPFs in this regard. Previous numerical studies by our group employing a detailed numerical model showed gravity effects to be significant on the PPF structure. We report on the results of microgravity experiments conducted on two-dimensional (established on a Wolfhard-Parker slot burner) and axisymmetric flames (on a coannular burner) that were investigated in a self-contained multipurpose rig. Thermocouple and radiometer data were also used to characterize the thermal transport in the flame.

  17. Estimation of partial decoupling of cavity events

    SciTech Connect

    Garbin, H D

    1993-03-01

    One proven method of evading the detection of a nuclear test is to decouple the explosion with a large air-filled cavity. Past tests have shown it is possible to substantially reduce the seismic energy emanating from a nuclear explosion by as much as two, orders of magnitude. The problem is not whether it can be done; the problem is the expense involved in mining a large cavity to fully decouple any reasonable size test. It has been suggested that partial decoupling may exist so some fraction of decoupling may be attained between factors of 1 to 100. MISTY ECHO and MINERAL QUARRY are two nuclear tests which were instrumented to look at this concept. MISTY ECHO was a nuclear explosion conducted in an 11 m hemispherical cavity such that the walls were over driven and reacted in a non-linear manner. MINERAL QUARRY was a nearby tamped event that is used as a reference to compare with MISTY ECHO. The scaled cavity radius of MISTY ECHO was greater than 2m/kt[sup l/3]. Both of these tests had free-field accelerometers located within 400 m of their respective sources. Analysis of surface ground motion is inconclusive on the question of partial decoupling. This is due to the difference in medium properties that the ray paths take to the surface. The free-field configuration alleviates this concern. The analysis consists of cube-root signal MINERAL QUARRYs signal to MISTY ECHO's yield and calculating the ratio of the Fourier amplitudes of both the acceleration and the reduced displacement potentials. The results do not indicate the presence of partial decoupling. In fact, there is a coupling enhancement factor of 2.

  18. Estimation of partial decoupling of cavity events

    SciTech Connect

    Garbin, H.D.

    1993-03-01

    One proven method of evading the detection of a nuclear test is to decouple the explosion with a large air-filled cavity. Past tests have shown it is possible to substantially reduce the seismic energy emanating from a nuclear explosion by as much as two, orders of magnitude. The problem is not whether it can be done; the problem is the expense involved in mining a large cavity to fully decouple any reasonable size test. It has been suggested that partial decoupling may exist so some fraction of decoupling may be attained between factors of 1 to 100. MISTY ECHO and MINERAL QUARRY are two nuclear tests which were instrumented to look at this concept. MISTY ECHO was a nuclear explosion conducted in an 11 m hemispherical cavity such that the walls were over driven and reacted in a non-linear manner. MINERAL QUARRY was a nearby tamped event that is used as a reference to compare with MISTY ECHO. The scaled cavity radius of MISTY ECHO was greater than 2m/kt{sup l/3}. Both of these tests had free-field accelerometers located within 400 m of their respective sources. Analysis of surface ground motion is inconclusive on the question of partial decoupling. This is due to the difference in medium properties that the ray paths take to the surface. The free-field configuration alleviates this concern. The analysis consists of cube-root signal MINERAL QUARRYs signal to MISTY ECHO`s yield and calculating the ratio of the Fourier amplitudes of both the acceleration and the reduced displacement potentials. The results do not indicate the presence of partial decoupling. In fact, there is a coupling enhancement factor of 2.

  19. Linear partial difference equations of hypergeometric type

    NASA Astrophysics Data System (ADS)

    Rodal, J.; Area, I.; Godoy, E.

    2007-03-01

    In this paper a systematic study of the orthogonal polynomial solutions of a second order partial difference equation of hypergeometric type of two variables is done. The Pearson's systems for the orthogonality weight of the solutions and also for the difference derivatives of the solutions are presented. The orthogonality property in subspaces is treated in detail, which leads to an analog of the Rodrigues-type formula for orthogonal polynomials of two discrete variables. A classification of the admissible equations as well as some examples related with bivariate Hahn, Kravchuk, Meixner, and Charlier families, and their algebraic and difference properties are explicitly given.

  20. Average characteristics of partially coherent electromagnetic beams.

    PubMed

    Seshadri, S R

    2000-04-01

    Average characteristics of partially coherent electromagnetic beams are treated with the paraxial approximation. Azimuthally or radially polarized, azimuthally symmetric beams and linearly polarized dipolar beams are used as examples. The change in the mean squared width of the beam from its value at the location of the beam waist is found to be proportional to the square of the distance in the propagation direction. The proportionality constant is obtained in terms of the cross-spectral density as well as its spatial spectrum. The use of the cross-spectral density has advantages over the use of its spatial spectrum.

  1. Partial muscle carnitine palmitoyltransferase-A deficiency

    SciTech Connect

    Ross, N.S.; Hoppel, C.L.

    1987-01-02

    After initiation of ibuprofen therapy, a 45-year-old woman developed muscle weakness and tenderness with rhabdomyolysis, culminating in respiratory failure. A muscle biopsy specimen showed a vacuolar myopathy, and markedly decreased muscle carnitine content and carnitine palmitoyltransferase activity. Following recovery, muscle carnitine content was normal but carnitine palmitoyltransferase activity was still abnormally low. The ratio of palmitoyl-coenzyme A plus carnitine to palmitoylcarnitine oxidation by muscle mitochondria isolated from the patient was markedly decreased. The authors conclude that transiently decreased muscle carnitine content interacted with partial deficiency of carnitine palmitoyltransferase-A to produce rhabdomyolysis and respiratory failure and that ibuprofen may have precipitated the clinical event.

  2. Computing Partial Transposes and Related Entanglement Functions

    NASA Astrophysics Data System (ADS)

    Maziero, Jonas

    2016-10-01

    The partial transpose (PT) is an important function for entanglement testing and quantification and also for the study of geometrical aspects of the quantum state space. In this article, considering general bipartite and multipartite discrete systems, explicit formulas ready for the numerical implementation of the PT and of related entanglement functions are presented and the Fortran code produced for that purpose is described. What is more, we obtain an analytical expression for the Hilbert-Schmidt entanglement of two-qudit systems and for the associated closest separable state. In contrast to previous works on this matter, we only use the properties of the PT, not applying Lagrange multipliers.

  3. The geometry of the partial realization problem

    NASA Technical Reports Server (NTRS)

    Brockett, R. W.; Hall, P.

    1979-01-01

    It is shown that the space of sequences of length n which have an extrapolation of McMillan degree k, and no extrapolations of lower McMillan degree can be given the structure of a differentiable manifold. This approach makes the proof of certain known results on the partial realization problem quite straightforward and makes it possible to establish some important new results as well. A key tool is the fact, proven here, that the set of n by a real Hankel matrices of rank r is a manifold with r+1 connected components.

  4. Multiple Partial Siberian Snakes in the AGS

    SciTech Connect

    Takano, J.; Ahrens, L. A.; Bai, M.; Brown, K.; Courant, E. D.; Gardner, C. J.; Glenn, J. W.; Huang, H.; Luccio, A. U.; MacKay, W. W.; Okamura, M.; Roser, T.; Tepikian, S.; Tsoupas, N.; Yip, K.; Zelenski, A.; Zeno, K.; Hattori, T.; Lin, F.

    2007-06-13

    Polarized protons are accelerated up to 24.3 GeV in the Alternating Gradient Synchrotron (AGS) at Brookhaven National Laboratory (BNL). To accelerate the beam with preserving the polarization, two different types of helical dipole partial Siberian snake have been installed to the AGS. One is a superconducting magnet (Cold Snake, CSNK), and the other is a normal conducting one (Warm Snake, WSNK). With these snake magnets, the polarization at the AGS extraction achieved 65%. However, the AGS has spin mismatches at the injection and extraction. This description shows calculated results to have better spin matching with using two or three snakes.

  5. Partial Arc Curvilinear Direct Drive Servomotor

    NASA Technical Reports Server (NTRS)

    Sun, Xiuhong (Inventor)

    2014-01-01

    A partial arc servomotor assembly having a curvilinear U-channel with two parallel rare earth permanent magnet plates facing each other and a pivoted ironless three phase coil armature winding moves between the plates. An encoder read head is fixed to a mounting plate above the coil armature winding and a curvilinear encoder scale is curved to be co-axis with the curvilinear U-channel permanent magnet track formed by the permanent magnet plates. Driven by a set of miniaturized power electronics devices closely looped with a positioning feedback encoder, the angular position and velocity of the pivoted payload is programmable and precisely controlled.

  6. Partial stability and stabilisation of Boolean networks

    NASA Astrophysics Data System (ADS)

    Chen, Hong-Wei; Sun, Liang-Jie; Liu, Yang

    2016-07-01

    In this paper, we investigate the stability of Boolean networks and the stabilisation of Boolean control networks with respect to part of the system's states. First, an algebraic expression of the Boolean (control) network is derived by the semi-tensor product of matrices. Then, some necessary and sufficient conditions for partial stability of Boolean networks are given. Finally, the stabilisation of Boolean control networks by a free control sequence and a state-feedback control is investigated and the respective necessary and sufficient conditions are obtained. Examples are provided to illustrate the efficiency of the obtained results.

  7. Resistance to extinction after schedules of partial delay or partial reinforcement in rats with hippocampal lesions.

    PubMed

    Rawlins, J N; Feldon, J; Ursin, H; Gray, J A

    1985-01-01

    Two experimental procedures were employed to establish the reason why hippocampal lesions apparently block the development of tolerance for aversive events in partial reinforcement experiments, but do not do so in partial punishment experiments. Rats were trained to run in a straight alley following hippocampal lesions (HC), cortical control lesions (CC) or sham operations (SO), and resistance to extinction was assessed following differing acquisition conditions. In Experiment 1 a 4-8 min inter-trial interval (ITI) was used. Either every acquisition trial was rewarded immediately (Continuous Reinforcement, CR), or only a randomly selected half of the trials were immediately rewarded, the reward being delayed for thirty seconds on the other trials (Partial Delay, PD). This delay procedure produced increased resistance to extinction in rats in all lesion groups. In Experiment 2 the ITI was reduced to a few seconds, and rats were trained either on a CR schedule, or on a schedule in which only half the trials were rewarded (Partial Reinforcement, PR). This form of partial reinforcement procedure also produced increased resistance to extinction in rats in all lesion groups. It thus appears that hippocampal lesions only prevent the development of resistance to aversive events when the interval between aversive and subsequent appetitive events exceeds some minimum value. PMID:4029302

  8. Long-term results of complete and partial ligation of congenital portosystemic shunts in dogs.

    PubMed

    Hottinger, H A; Walshaw, R; Hauptman, J G

    1995-01-01

    The medical records of 65 dogs that underwent complete or partial ligation of a single congenital portosystemic shunt (CPSS) were reviewed to determine the long-term clinical clinical results. Information retrieved from the records included age at surgery, preligation (baseline) portal pressure, postligation portal pressure, change in portal pressure from baseline, complete or partial occlusion of the shunting vessel and fasting, and 2-hour postprandial bile acids from the preoperative, early postoperative (PO), and greater than 1 year PO time periods. A clinical rating score derived from a follow-up examination greater than 1 year PO was assigned to each dog. Of the 56 dogs that survived the perioperative period, 29 (52%) had complete and 27 (48%) had partial ligations. Age at surgery, pre- and postligation portal pressure, change in portal pressure from baseline and serum bile acid concentrations were not related to long-term clinical outcome. Clinical rating scores were significantly greater for dogs with partial CPSS ligations compared with dogs with complete ligations, indicating a less favorable clinical outcome for partial ligations. Fasting and 2-hour postprandial bile acid values at both PO time intervals were significantly greater in partial versus complete ligation groups. Follow-up information for more than 1 year was available on 18 of 29 dogs (62%) with complete ligations. All were clinically normal. Of 27 dogs with partial ligations, 11 dogs (41%) developed recurrence of clinical signs resulting in presentation to the university or referring veterinarian for additional surgery, medical management, or euthanasia. Only three dogs with partial CPSS ligation (11%) were clinically normal.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7571385

  9. Danazol therapy in haemophilia.

    PubMed

    Heaton, D C; Wyld, P J; Conder, J L

    1986-03-26

    Three patients with severe haemophilia A and one patient with moderately severe Christmas disease were given danazol and placebo in a double blind cross over trial to study the effects on haemostatic variables and bleeding tendency. In each case there was a shortening of the activated partial thromboplastin time (APTT) and euglobulin clot lysis time (ECLT) during danazol therapy but factor VIII and IX levels did not show any consistent change and there was no improvement in the bleeding tendency.

  10. PARTIAL TRISOMY 4p AND PARTIAL MONOSOMY 13q: CASE REPORT AND A LITERATURE REVIEW.

    PubMed

    Puvabanditsin, S; Herrera-Garcia, G; Gengel, N; Hussein, K; February, M; Mayne, J; Mehta, R

    2016-01-01

    We report on a term first born dichorionic-diamniotic twin with deletion of the distal long arm of chromosome 13, partial trisomy of the short arm of chromosome 4, intrauterine growth retardation, and multiple anomalies including microcephaly, colpocephaly, absent corpus callosum, bulbous tip of the nose, large and low set ears, macroglossia, thin upper lip, double outlet right ventricle, atria/ventricular septal defect, cleft mitral valve, pulmonary stenosis, single umbilical artery, multicystic dysplastic left kidney, sacral dimple, anterior displacement of anus, simian creases, abnormal thumb (congenital clasped thumb), overlapping toes, and congenital hypothyroidism. This is the first report of a patient with partial trisomy 4p and partial monosomy 13q. PMID:27192890

  11. Partial spatial coherence and partial polarization in random evanescent fields on lossless interfaces.

    PubMed

    Norrman, Andreas; Setälä, Tero; Friberg, Ari T

    2011-03-01

    We consider partial spatial coherence and partial polarization of purely evanescent optical fields generated in total internal reflection at an interface of two dielectric (lossless) media. Making use of the electromagnetic degree of coherence, we show that, in such fields, the coherence length can be notably shorter than the light's vacuum wavelength, especially at a high-index-contrast interface. Physical explanation for this behavior, analogous to the generation of incoherent light in a multimode laser, is provided. We also analyze the degree of polarization by using a recent three-dimensional formulation and show that the field may be partially polarized at a subwavelength distance from the surface even though it is fully polarized farther away. The degree of polarization can assume values unattainable by beamlike fields, indicating that electromagnetic evanescent waves generally are genuine three-dimensional fields. The results can find applications in near-field optics and nanophotonics.

  12. Alcalase rapeseed inhibitors: purification and partial characterization.

    PubMed

    Vioque, J; Sánchez-Vioque, R; Clemente, A; Pedroche, J; Mar Yust, M; Millán, F

    2001-01-01

    Extensive rapeseed protein hydrolysate obtained sequentially with Alcalase and Flavourzyme showed inhibitory activity towards Alcalase. Inhibitory activity decreased as the hydrolytic process progressed probably by heat denaturation and/or partial protease degradation. Alcalase rapeseed inhibitors were purified by gel filtration and subsequent ion exchange chromatography. They are composed of peptides of 8.4 and 6.1 kDa linked by interchain disulphide bonds, as observed by reducing SDS-PAGE, with a native molecular weight of 18 kDa. Aminoacid composition of the inhibitors was characterized by the high proportion of methionine (4.2%) and cysteine (4.6%). Alcalase inhibitors were partially resistant to heat treatment; after heating at 70 degrees C for 45 minutes more than 50% of the original inhibitory activity remained in the purified protein but after heating at 90 degrees C for 5 minutes, inhibitory activity decreased very fast to a basal level. The possible relation of these protease inhibitors with the 2S albumin storage proteins is discussed.

  13. Partial volume correction using cortical surfaces

    NASA Astrophysics Data System (ADS)

    Blaasvær, Kamille R.; Haubro, Camilla D.; Eskildsen, Simon F.; Borghammer, Per; Otzen, Daniel; Ostergaard, Lasse R.

    2010-03-01

    Partial volume effect (PVE) in positron emission tomography (PET) leads to inaccurate estimation of regional metabolic activities among neighbouring tissues with different tracer concentration. This may be one of the main limiting factors in the utilization of PET in clinical practice. Partial volume correction (PVC) methods have been widely studied to address this issue. MRI based PVC methods are well-established.1 Their performance depend on the quality of the co-registration of the MR and PET dataset, on the correctness of the estimated point-spread function (PSF) of the PET scanner and largely on the performance of the segmentation method that divide the brain into brain tissue compartments.1, 2 In the present study a method for PVC is suggested, that utilizes cortical surfaces, to obtain detailed anatomical information. The objectives are to improve the performance of PVC, facilitate a study of the relationship between metabolic activity in the cerebral cortex and cortical thicknesses, and to obtain an improved visualization of PET data. The gray matter metabolic activity after performing PVC was recovered by 99.7 - 99.8 % , in relation to the true activity when testing on simple simulated data with different PSFs and by 97.9 - 100 % when testing on simulated brain PET data at different cortical thicknesses. When studying the relationship between metabolic activities and anatomical structures it was shown on simulated brain PET data, that it is important to correct for PVE in order to get the true relationship.

  14. Controllability of the better chosen partial networks

    NASA Astrophysics Data System (ADS)

    Liu, Xueming; Pan, Linqiang

    2016-08-01

    How to control large complex networks is a great challenge. Recent studies have proved that the whole network can be sufficiently steered by injecting control signals into a minimum set of driver nodes, and the minimum numbers of driver nodes for many real networks are high, indicating that it is difficult to control them. For some large natural and technological networks, it is impossible and not feasible to control the full network. For example, in biological networks like large-scale gene regulatory networks it is impossible to control all the genes. This prompts us to explore the question how to choose partial networks that are easy for controlling and important in networked systems. In this work, we propose a method to achieve this goal. By computing the minimum driver nodes densities of the partial networks of Erdös-Rényi (ER) networks, scale-free (SF) networks and 23 real networks, we find that our method performs better than random method that chooses nodes randomly. Moreover, we find that the nodes chosen by our method tend to be the essential elements of the whole systems, via studying the nodes chosen by our method of a real human signaling network and a human protein interaction network and discovering that the chosen nodes from these networks tend to be cancer-associated genes. The implementation of our method shows some interesting connections between the structure and the controllability of networks, improving our understanding of the control principles of complex systems.

  15. Adaptive Estimation with Partially Overlapping Models

    PubMed Central

    Shin, Sunyoung; Fine, Jason; Liu, Yufeng

    2015-01-01

    In many problems, one has several models of interest that capture key parameters describing the distribution of the data. Partially overlapping models are taken as models in which at least one covariate effect is common to the models. A priori knowledge of such structure enables efficient estimation of all model parameters. However, in practice, this structure may be unknown. We propose adaptive composite M-estimation (ACME) for partially overlapping models using a composite loss function, which is a linear combination of loss functions defining the individual models. Penalization is applied to pairwise differences of parameters across models, resulting in data driven identification of the overlap structure. Further penalization is imposed on the individual parameters, enabling sparse estimation in the regression setting. The recovery of the overlap structure enables more efficient parameter estimation. An oracle result is established. Simulation studies illustrate the advantages of ACME over existing methods that fit individual models separately or make strong a priori assumption about the overlap structure. PMID:26917931

  16. Partial facetectomy for lumbar foraminal stenosis.

    PubMed

    Kang, Kevin; Rodriguez-Olaverri, Juan Carlos; Schwab, Frank; Hashem, Jenifer; Razi, Afshin; Farcy, Jean Pierre

    2014-01-01

    Background. Several different techniques exist to address the pain and disability caused by isolated nerve root impingement. Failure to adequately decompress the lumbar foramen may lead to failed back surgery syndrome. However, aggressive treatment often causes spinal instability or may require fusion for satisfactory results. We describe a novel technique for decompression of the lumbar nerve root and demonstrate its effectiveness in relief of radicular symptoms. Methods. Partial facetectomy was performed by removal of the medial portion of the superior facet in patients with lumbar foraminal stenosis. 47 patients underwent the procedure from 2001 to 2010. Those who demonstrated neurogenic claudication without spinal instability or central canal stenosis and failed conservative management were eligible for the procedure. Functional level was recorded for each patient. These patients were followed for an average of 3.9 years to evaluate outcomes. Results. 27 of 47 patients (57%) reported no back pain and no functional limitations. Eight of 47 patients (17%) reported moderate pain, but had no limitations. Six of 47 patients (13%) continued to experience degenerative symptoms. Five of 47 patients (11%) required additional surgery. Conclusions. Partial facetectomy is an effective means to decompress the lumbar nerve root foramen without causing spinal instability.

  17. Genetics Home Reference: autosomal dominant partial epilepsy with auditory features

    MedlinePlus

    ... Genetics Home Health Conditions ADPEAF autosomal dominant partial epilepsy with auditory features Enable Javascript to view the ... Open All Close All Description Autosomal dominant partial epilepsy with auditory features ( ADPEAF ) is an uncommon form ...

  18. Partial oxidation power plant with reheating and method thereof

    DOEpatents

    Newby, Richard A.; Yang, Wen-Ching; Bannister, Ronald L.

    1999-01-01

    A system and method for generating power having an air compression/partial oxidation system, a turbine, and a primary combustion system. The air compression/partial oxidation system receives a first air stream and a fuel stream and produces a first partially oxidized fuel stream and a first compressed air stream therefrom. The turbine expands the first partially oxidized fuel stream while being cooled by the first compressed air stream to produce a heated air stream. The heated air stream is injected into the expanding first partially oxidized fuel stream, thereby reheating it in the turbine. A second partially oxidized fuel stream is emitted from the turbine. The primary combustion system receives said second partially oxidized fuel stream and a second air stream, combusts said second partially oxidized fuel stream, and produces rotating shaft power and an emission stream therefrom.

  19. Partial oxidation power plant with reheating and method thereof

    DOEpatents

    Newby, R.A.; Yang, W.C.; Bannister, R.L.

    1999-08-10

    A system and method are disclosed for generating power having an air compression/partial oxidation system, a turbine, and a primary combustion system. The air compression/partial oxidation system receives a first air stream and a fuel stream and produces a first partially oxidized fuel stream and a first compressed air stream therefrom. The turbine expands the first partially oxidized fuel stream while being cooled by the first compressed air stream to produce a heated air stream. The heated air stream is injected into the expanding first partially oxidized fuel stream, thereby reheating it in the turbine. A second partially oxidized fuel stream is emitted from the turbine. The primary combustion system receives said second partially oxidized fuel stream and a second air stream, combusts said second partially oxidized fuel stream, and produces rotating shaft power and an emission stream therefrom. 2 figs.

  20. Overall coherence and coherent-mode expansion of spectrally partially coherent plane-wave pulses.

    PubMed

    Lajunen, Hanna; Tervo, Jani; Vahimaa, Pasi

    2004-11-01

    The modal theory for spectrally partially coherent nonstationary plane waves is introduced. The theory is first developed in the space-frequency domain and then extended to the space-time domain. Propagation properties of the coherent modes are analyzed. The concept of the overall degree of coherence is extended to the domain of nonstationary fields, and it is shown that the overall degree of coherence of partially coherent plane-wave pulses is the same in the space-frequency and space-time domains. The theory is applied to the recently introduced concept of spectrally Gaussian Schell-model plane-wave pulses.

  1. Overall coherence and coherent-mode expansion of spectrally partially coherent plane-wave pulses

    NASA Astrophysics Data System (ADS)

    Lajunen, Hanna; Tervo, Jani; Vahimaa, Pasi

    2004-11-01

    The modal theory for spectrally partially coherent nonstationary plane waves is introduced. The theory is first developed in the space-frequency domain and then extended to the space-time domain. Propagation properties of the coherent modes are analyzed. The concept of the overall degree of coherence is extended to the domain of nonstationary fields, and it is shown that the overall degree of coherence of partially coherent plane-wave pulses is the same in the space-frequency and space-time domains. The theory is applied to the recently introduced concept of spectrally Gaussian Schell-model plane-wave pulses.

  2. Diode laser supported partial nephrectomy in laparoscopic surgery: preliminary results

    NASA Astrophysics Data System (ADS)

    Sroka, Ronald; Hennig, Georg; Zillinberg, Katja; Khoder, Wael Y.

    2011-07-01

    Introduction: Warm ischemia and bleeding during laparoscopic partial nephrectomy place technical constraints on surgeons. Therefore it was the aim to develop a safe and effective laser assisted partial nephrectomy technique without need for ischemia. Patients and methods: A diode laser emitting light at 1318nm in cw mode was coupled into a bare fibre (core diameter 600 μm) thus able to transfer up to 100W to the tissue. After dry lab experience, a total of 8 patients suffering from kidney malformations underwent laparoscopic/retroperitoneoscopic partial nephrectomy. Clinically, postoperative renal function and serum c-reactive protein (CRP) were monitored. Laser induced coagulation depth and effects on resection margins were evaluated. Demographic, clinical and follow-up data are presented. Results: Overall interventions, the mean operative time was 116,5 minutes (range 60-175min) with mean blood loss of 238ml (range 50-600ml) while laser assisted resection of the kidney tissue took max 15min. After extirpation of the tumours all patients showed clinical favourable outcome during follow up period. The tumour size was measured to be 1.8 to 5cm. With respect to clinical safety and due to blood loos, two warm ischemia (19 and 24min) must be performed. Immediate postoperative serum creatinine and CRP were elevated within 0.1 to 0.6 mg/dl (mean 0.18 mg/dl) and 2.1-10 mg/dl (mean 6.24 mg/dl), respectively. The depth of the coagulation on the removed tissue ranged between <1 to 2mm without effect on histopathological evaluation of tumours or resection margin. As the surface of the remaining kidney surface was laser assisted coagulated after removal. The sealing of the surface was induced by a slightly larger coagulation margin, but could not measured so far. Conclusion: This prospective in-vivo feasibility study shows that 1318nm-diode laser assisted partial nephrectomy seems to be a safe and promising medical technique which could be provided either during open surgery

  3. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    SciTech Connect

    Archie Robertson

    2002-07-10

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the April 1--June 30, 2002 time period.

  4. Development of Pressurized Circulating Fluidized Bed Partial Gasification Module (PGM)

    SciTech Connect

    A. Robertson

    2002-09-30

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the July 1-September 30, 2002 time period.

  5. Development of Pressurized Circulating Fluidized Bed Partial Gasification Module (PGM)

    SciTech Connect

    A. Robertson

    2003-12-31

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the October 1 - December 31, 2003 time period.

  6. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    SciTech Connect

    Unknown

    2003-01-30

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the October 1--December 31, 2002 time period.

  7. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    SciTech Connect

    Archie Robertson

    2003-07-23

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the April 1--June 30, 2003 time period.

  8. DEVELOPMENT OF PRESSURIZED CIRCULATING FLUIDIZED BED PARTIAL GASIFICATION MODULE (PGM)

    SciTech Connect

    Archie Robertson

    2003-10-29

    Foster Wheeler Power Group, Inc. is working under US Department of Energy contract No. DE-FC26-00NT40972 to develop a partial gasification module (PGM) that represents a critical element of several potential coal-fired Vision 21 plants. When utilized for electrical power generation, these plants will operate with efficiencies greater than 60% and produce near zero emissions of traditional stack gas pollutants. The new process partially gasifies coal at elevated pressure producing a coal-derived syngas and a char residue. The syngas can be used to fuel the most advanced power producing equipment such as solid oxide fuel cells or gas turbines, or processed to produce clean liquid fuels or chemicals for industrial users. The char residue is not wasted; it can also be used to generate electricity by fueling boilers that drive the most advanced ultra-supercritical pressure steam turbines. The amount of syngas and char produced by the PGM can be tailored to fit the production objectives of the overall plant, i.e., power generation, clean liquid fuel production, chemicals production, etc. Hence, PGM is a robust building bock that offers all the advantages of coal gasification but in a more user-friendly form; it is also fuel flexible in that it can use alternative fuels such as biomass, sewerage sludge, etc. This report describes the work performed during the July 1--September 30, 2003 time period.

  9. Fluctuation Limit for Interacting Diffusions with Partial Annihilations Through Membranes

    NASA Astrophysics Data System (ADS)

    Chen, Zhen-Qing; Fan, Wai-Tong Louis

    2016-08-01

    We study fluctuations of the empirical processes of a non-equilibrium interacting particle system consisting of two species over a domain that is recently introduced in Chen and Fan (Ann Probab, to appear) and establish its functional central limit theorem. This fluctuation limit is a distribution-valued Gaussian Markov process which can be represented as a mild solution of a stochastic partial differential equation. The drift of our fluctuation limit involves a new partial differential equation with nonlinear coupled term on the interface that characterized the hydrodynamic limit of the system. The covariance structure of the Gaussian part consists two parts, one involving the spatial motion of the particles inside the domain and other involving a boundary integral term that captures the boundary interactions between two species. The key is to show that the Boltzmann-Gibbs principle holds for our non-equilibrium system. Our proof relies on generalizing the usual correlation functions to the join correlations at two different times.

  10. Facilitating Preemptive Hardware System Design Using Partial Reconfiguration Techniques

    PubMed Central

    Rincon, Fernando; Vaderrama, Carlos; Villanueva, Felix; Caba, Julian; Lopez, Juan Carlos

    2014-01-01

    In FPGA-based control system design, partial reconfiguration is especially well suited to implement preemptive systems. In real-time systems, the deadline for critical task can compel the preemption of noncritical one. Besides, an asynchronous event can demand immediate attention and, then, force launching a reconfiguration process for high-priority task implementation. If the asynchronous event is previously scheduled, an explicit activation of the reconfiguration process is performed. If the event cannot be previously programmed, such as in dynamically scheduled systems, an implicit activation to the reconfiguration process is demanded. This paper provides a hardware-based approach to explicit and implicit activation of the partial reconfiguration process in dynamically reconfigurable SoCs and includes all the necessary tasks to cope with this issue. Furthermore, the reconfiguration service introduced in this work allows remote invocation of the reconfiguration process and then the remote integration of off-chip components. A model that offers component location transparency is also presented to enhance and facilitate system integration. PMID:24672292

  11. Laboratory measurements of seismic attenuation in partially saturated rocks

    NASA Astrophysics Data System (ADS)

    Chapman, Samuel; Tisato, Nicola; Quintal, Beatriz; Holliger, Klaus

    2014-05-01

    Laboratory measurements of seismic attenuation and transient pore fluid pressure are performed on partially saturated Berea sandstone and synthetic borosilicate samples. Various degrees of water (liquid) and nitrogen (gas) saturation are considered. These measurements are carried out at room temperature and under confining pressures varying from ambient conditions up to 25 MPa. The cylindrical samples are 25 cm long and have a diameter of 7.6 cm. In the context of the experimental setup, the solid frames of both the Berea sandstone and the borosilicate samples can be considered homogenous, which in turn allows for isolating and exploring the effects of partial saturation on seismic attenuation. We employ the sub-resonance method, which is based on the application of a time-harmonic vertical stress to the top of the sample and the measurement of the thus resulting strain. For any given frequency, the attenuation is then inferred as the tangent of the phase shift between the applied stress and the observed strain. Using five equally spaced sensors along the central axis of the cylindrical sample, we measure the transient fluid pressure induced by the application of a step-function-type vertical stress to the top of the sample. Both the sensors and the sample are sealed off with the regard to the confining environment. Together with the numerical results from corresponding compressibility tests based on the quasi-static poroelastic equations, these transient fluid pressure measurements are then used to assist the interpretation of the seismic attenuation measurements.

  12. TMJ function after partial condylectomy in active mandibular condylar hyperplasia

    PubMed Central

    Olate, Sergio; Martinez, Felipe; Uribe, Francisca; Pozzer, Leandro; Cavalieri-Pereira, Lucas; de Moraes, Marcio

    2014-01-01

    Condylar hyperplasia is a frequent pathology that causes severe facial asymmetries. The partial condylectomy generally halts the disease. The aim of this research was to examine post-condylectomy TMJ function; 14 patients were included in this study, 6 male and 8 female. The average age was 21 years old. In all, the partial condylectomy was performed with preauricular or endaural access and the osteotomy were performed with drills, saw or an ultrasonic system. The patients were assessed with 3 or more time after surgery and were considering maximum mouth opening, right and left lateralities, presence of pain, noises, alterations in the facial nerve (VII) and esthetic alteration from the scar. The analysis was performed with the visual analog scale (VAS) and with a 7 cm metallic rule. Data analysis was descriptive plus chi-square test considering p value < 0.05 for statistical differences. With an average of 11 month after surgery, the results showed that the open mouth (over 35 mm) and lateralities (average 9 mm for the both right and left side) were normal and without statistical differences between the right or left side. Noise was observed in 3 patients and pain was observed in two patients with level 2 and 1 (VAS score). Scar was not related to problem with patient and the temporal branch of facial nerve was observed with limitations but without problem for patients. It can be concluded that the condylectomy is a safe and effective procedure with low morbidity for patients. PMID:24753777

  13. TMJ function after partial condylectomy in active mandibular condylar hyperplasia.

    PubMed

    Olate, Sergio; Martinez, Felipe; Uribe, Francisca; Pozzer, Leandro; Cavalieri-Pereira, Lucas; de Moraes, Marcio

    2014-01-01

    Condylar hyperplasia is a frequent pathology that causes severe facial asymmetries. The partial condylectomy generally halts the disease. The aim of this research was to examine post-condylectomy TMJ function; 14 patients were included in this study, 6 male and 8 female. The average age was 21 years old. In all, the partial condylectomy was performed with preauricular or endaural access and the osteotomy were performed with drills, saw or an ultrasonic system. The patients were assessed with 3 or more time after surgery and were considering maximum mouth opening, right and left lateralities, presence of pain, noises, alterations in the facial nerve (VII) and esthetic alteration from the scar. The analysis was performed with the visual analog scale (VAS) and with a 7 cm metallic rule. Data analysis was descriptive plus chi-square test considering p value < 0.05 for statistical differences. With an average of 11 month after surgery, the results showed that the open mouth (over 35 mm) and lateralities (average 9 mm for the both right and left side) were normal and without statistical differences between the right or left side. Noise was observed in 3 patients and pain was observed in two patients with level 2 and 1 (VAS score). Scar was not related to problem with patient and the temporal branch of facial nerve was observed with limitations but without problem for patients. It can be concluded that the condylectomy is a safe and effective procedure with low morbidity for patients. PMID:24753777

  14. SDO/AIA observations of a partially erupting prominence

    SciTech Connect

    Tripathi, Durgesh; Reeves, Katharine K.; Gibson, Sarah E.; Srivastava, Abhishek; Joshi, Navin C.

    2013-12-01

    We report an observation of a partially erupting prominence and its associated dynamical plasma processes based on observations recorded by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory. The prominence first went through a slow rise (SR) phase followed by a fast rise (FR) phase. The SR phase began after a couple of small brightenings were seen toward the footpoints. When the prominence had transitioned from SR to FR, it had already become kinked. The prominence shows strong brightening at the central kink location during the start of FR. We interpret this as an internal magnetic reconnection occurring at a vertical current sheet forming between the two legs of the erupting prominence (flux rope). The brightening at the central kink location is seen in all EUV channels of AIA. The contributions of differential emission at higher temperatures are larger compared to that for typical coronal temperatures supporting a reconnection scenario at the central kink location. The plasma above the brightening location is ejected as a hot plasmoid-like structure embedded in a coronal mass ejection, and those below the brightening move down in the form of blobs moving toward the Sun's surface. The unique time resolution of the AIA has allowed these eruptive aspects, including SR-to-FR, kinking, central current sheet formation, plasmoid-like eruption, and filament 'splitting', to be observed in a single event, providing strong and comprehensive evidence in favor of the model of partially erupting flux ropes.

  15. Partial migration: growth varies between resident and migratory fish

    PubMed Central

    Gillanders, Bronwyn M.; Izzo, Christopher; Doubleday, Zoë A.; Ye, Qifeng

    2015-01-01

    Partial migration occurs in many taxa and ecosystems and may confer survival benefits. Here, we use otolith chemistry data to determine whether fish from a large estuarine system were resident or migratory, and then examine whether contingents display differences in modelled growth based on changes in width of otolith growth increments. Sixty-three per cent of fish were resident based on Ba : Ca of otoliths, with the remainder categorized as migratory, with both contingents distributed across most age/size classes and both sexes, suggesting population-level bet hedging. Migrant fish were in slightly better condition than resident fish based on Fulton's K condition index. Migration type (resident versus migratory) was 56 times more likely to explain variation in growth than a model just incorporating year- and age-related growth trends. While average growth only varied slightly between resident and migratory fish, year-to-year variation was significant. Such dynamism in growth rates likely drives persistence of both life-history types. The complex relationships in growth between contingents suggest that management of species exhibiting partial migration is challenging, especially in a world subject to a changing climate. PMID:25788490

  16. Partial migration: growth varies between resident and migratory fish.

    PubMed

    Gillanders, Bronwyn M; Izzo, Christopher; Doubleday, Zoë A; Ye, Qifeng

    2015-03-01

    Partial migration occurs in many taxa and ecosystems and may confer survival benefits. Here, we use otolith chemistry data to determine whether fish from a large estuarine system were resident or migratory, and then examine whether contingents display differences in modelled growth based on changes in width of otolith growth increments. Sixty-three per cent of fish were resident based on Ba : Ca of otoliths, with the remainder categorized as migratory, with both contingents distributed across most age/size classes and both sexes, suggesting population-level bet hedging. Migrant fish were in slightly better condition than resident fish based on Fulton's K condition index. Migration type (resident versus migratory) was 56 times more likely to explain variation in growth than a model just incorporating year- and age-related growth trends. While average growth only varied slightly between resident and migratory fish, year-to-year variation was significant. Such dynamism in growth rates likely drives persistence of both life-history types. The complex relationships in growth between contingents suggest that management of species exhibiting partial migration is challenging, especially in a world subject to a changing climate. PMID:25788490

  17. Partial reduction of particulate iron ores and cyclone reactor

    SciTech Connect

    Taylor, P.R.; Bartlett, R.W.; Abdel-Latif, M.

    1993-07-20

    An apparatus for iron or ferro-alloy smelting is described, comprising: bath smelter means for containing a smelting bath for reductive bath smelting of iron or ferro-alloy ore by coal/oxygen injection through use of endothermic nozzles directed into a smelting bath to form liquid iron or steel; a closed cyclone reactor having an upper end including an inlet end, said closed cyclone including an open lower exit positioned above the smelting bath within the bath smelter means; feed means for directing a continuous stream of fine ore particles into the cyclone reactor; and gas supply means for tangentially directing streams of oxygen, with or without air, and a fuel gas selected from the group consisting of producer gas, natural gas and methane for burning within the cyclone reactor to maintain the interior and contents of the cyclone reactor at an elevated temperature; the equilibrium partial pressure ratio of carbon monoxide to carbon dioxide exiting the cyclone reactor being maintained at a value sufficient to cause the melted ore at the elevated temperatures within the cyclone reactor to be partially reduced during the particulate residence time within the cyclone reactor.

  18. Changes in spatiotemporal patterns of hydrological response after partial deforestation

    NASA Astrophysics Data System (ADS)

    Wiekenkamp, Inge; Huisman, Johan Alexander; Reemt Bogena, Heye; Lin, Henry; Drüe, Clemens; Vereecken, Harry

    2016-04-01

    Predicting the effects of land use change on hydrology can be extremely challenging. It requires looking beyond the current structure and functioning of hydrological systems to predict how the system is influenced in a changed setting. Although the hydrological effects of land use change have been studied extensively, only few high resolution datasets are available to accurately describe, model and predict detailed changes in spatiotemporal patterns of hydrological fluxes and states due to land use change. The TERENO test site Wüstebach provides a unique monitoring setup to measure the major components of the water balance (evapotranspiration, discharge, precipitation) and the spatiotemporal distribution of soil moisture before and after a partial deforestation. Here, we present 5 years of measured hydrological data, including soil moisture and water budget component data 3 years before and 2 years after the partial deforestation. A data-driven investigation was used to understand changes and related feedback mechanisms in spatiotemporal hydrological response patterns. The effects of deforestation on soil moisture and evapotranspiration were analyzed by comparing states and fluxes for the control and the deforested area. The effects on discharge characteristics were analyzed using discharge metrics, including baseflow separation, peakflow rates and time to peak. Changes in preferential flow occurrence were identified using a sensor response time analysis of soil moisture measurements before and after the deforestation where preferential flow was identified as a non-sequential sequence of sensor response times within the soil. As expected from earlier studies, the partial deforestation caused a decrease in evapotranspiration and an increase in discharge. A closer look at the high resolution datasets however reveals new insights in the intra-annual variability of the water balance components. The overall decrease in evapotranspiration caused a large increase in soil

  19. A clinical survey of removable partial dentures. --Analysis of follow-up examinations over a sixteen-year period--.

    PubMed

    Nakazawa, I

    1977-03-01

    In order to carry out the proper prosthetic treatment, it is necessary to select the method of treatment on the basis of accurate information concerning the prognosis of the prosthetic appliance. The oral structures are particularly proved to change when partial dentures are being used because the structures of the partial dentures are quite complex and they are easily broken. Therefore, in an attempt to analyze the changes that occur in the oral structures and partial dentures after insertion of the partial dentures, we conducted 3 series of follow-up examinations. The author sent out questionnaires and also conducted follow-up examinations of the patients. A summary of the major findings is as follows: 1) The percentage of those patients who came for their follow-up examinations, using metal based dentures, rose sharply over time. There were only 11.99% of the patients using the metal based dentures at the time the first study was conducted, but this rose to 58.13% at the time of the second study and 73.73% at the time of the third study. 2) The proportion of the patients who had anterior partial dentures declined over time from 9.36% at the time of the first study to 8.74% at the time of the second study and finally to 5.61% at the time of the third study. 3) The proportion of the partial dentures that had fractured was 23.15% at the time of the first study and 16.37% at the time of the second study and 16.67% at the time of the third study. 4) There was a striking difference in the fracture frequency of the acrylic resin based partial dentures and that of the metal based partial dentures. The denture bases of the acrylic resin-based partial dentures fractured about four times as often as those of the metal based partial dentures. 5) In all three studies it was found that about 60% of the caries occuring on the abutment tooth occurred on the edentulous proximal side. 6) Changes in the mucous membrane, such as inflammation or development of ulcers, had occurred

  20. 48 CFR 819.502-3 - Partial set-asides.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Partial set-asides. 819... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Set-Asides for Small Business 819.502-3 Partial set-asides. When... particular procurement will be partially set aside for small business participation, the solicitation...