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Sample records for parton model target

  1. QCD parton model at collider energies

    SciTech Connect

    Ellis, R.K.

    1984-09-01

    Using the example of vector boson production, the application of the QCD improved parton model at collider energies is reviewed. The reliability of the extrapolation to SSC energies is assessed. Predictions at ..sqrt..S = 0.54 TeV are compared with data. 21 references.

  2. New model for nucleon generalized parton distributions

    SciTech Connect

    Radyushkin, Anatoly V.

    2014-01-01

    We describe a new type of models for nucleon generalized parton distributions (GPDs) H and E. They are heavily based on the fact nucleon GPDs require to use two forms of double distribution (DD) representations. The outcome of the new treatment is that the usual DD+D-term construction should be amended by an extra term, {xi} E{sub +}{sup 1} (x,{xi}) which has the DD structure {alpha}/{beta} e({beta},{alpha}, with e({beta},{alpha}) being the DD that generates GPD E(x,{xi}). We found that this function, unlike the D-term, has support in the whole -1 <= x <= 1 region. Furthermore, it does not vanish at the border points |x|={xi}.

  3. Generalized Valon Model for Double Parton Distributions

    NASA Astrophysics Data System (ADS)

    Broniowski, Wojciech; Ruiz Arriola, Enrique; Golec-Biernat, Krzysztof

    2016-06-01

    We show how the double parton distributions may be obtained consistently from the many-body light-cone wave functions. We illustrate the method on the example of the pion with two Fock components. The procedure, by construction, satisfies the Gaunt-Stirling sum rules. The resulting single parton distributions of valence quarks and gluons are consistent with a phenomenological parametrization at a low scale.

  4. Nucleon parton distributions in a light-front quark model

    NASA Astrophysics Data System (ADS)

    Gutsche, Thomas; Lyubovitskij, Valery E.; Schmidt, Ivan

    2017-02-01

    Continuing our analysis of parton distributions in the nucleon, we extend our light-front quark model in order to obtain both the helicity-independent and the helicity-dependent parton distributions, analytically matching the results of global fits at the initial scale μ ˜ 1 GeV; they also contain the correct Dokshitzer-Gribov-Lipatov-Altarelli-Parisi evolution. We also calculate the transverse parton, Wigner and Husimi distributions from a unified point of view, using our light-front wave functions and expressing them in terms of the parton distributions q_v(x) and δ q_v(x). Our results are very relevant for the current and future program of the COMPASS experiment at SPS (CERN).

  5. Concurrent approaches to Generalized Parton Distribution modeling: the pion's case

    NASA Astrophysics Data System (ADS)

    Chouika, N.; Mezrag, C.; Moutarde, H.; Rodríguez-Quintero, J.

    2017-03-01

    The concept of Generalized Parton Distributions promises an understanding of the generation of the charge, spin, and energy-momentum structure of hadrons by quarks and gluons. Forthcoming measurements with unprecedented accuracy at Jefferson Lab and at CERN will challenge our quantitative description of the three-dimensional structure of hadrons. To fully exploit these future measurements, new tools and models are currently being developed. We explain the difficulties of Generalized Parton Distribution modeling, and present some recent progresses. In particular we describe the symmetry-preserving Dyson-Schwinger and Bethe-Salpeter framework. We also discuss various equivalent parameterizations and sketch how to combine them to obtain models satisfying a priori all required theoretical constraints. At last we explain why these developments naturally fit in a versatile software framework, named PARTONS, dedicated to the theory and phenomenology of GPDs.

  6. Backward dilepton production in color dipole and parton models

    SciTech Connect

    Gay Ducati, Maria Beatriz; Graeve de Oliveira, Emmanuel

    2010-03-01

    The Drell-Yan dilepton production at backward rapidities is studied in proton-nucleus collisions at Relativistic Heavy Ion Collider and LHC energies by comparing two different approaches: the k{sub T} factorization at next-to-leading order with intrinsic transverse momentum and the same process formulated in the target rest frame, i.e., the color dipole approach. Our results are expressed in terms of the ratio between p(d)-A and p-p collisions as a function of transverse momentum and rapidity. Three nuclear parton distribution functions are used: EKS (Eskola, Kolhinen, and Ruuskanen), EPS08, and EPS09 and, in both approaches, dileptons show sensitivity to nuclear effects, specially regarding the intrinsic transverse momentum. Also, there is room to discriminate between formalisms: the color dipole approach lacks soft effects introduced by the intrinsic k{sub T}. Geometric scaling GBW (Golec-Biernat and Wusthoff) and BUW (Boer, Utermann, and Wessels) color dipole cross section models and also a DHJ (Dumitru, Hayashigaki, and Jalilian-Marian) model, which breaks geometric scaling, are used. No change in the ratio between collisions is observed, showing that this observable is not changed by the particular shape of the color dipole cross section. Furthermore, our k{sub T} factorization results are compared with color glass condensate results at forward rapidities: the results agree at Relativistic Heavy Ion Collider although disagree at LHC, mainly due to the different behavior of target gluon and quark shadowing.

  7. Longitudinal and Transverse Parton Momentum Distributions for Hadrons within Relativistic Constituent Quark Models

    SciTech Connect

    Frederico, T.; Pace, E.; Pasquini, B.; Salme, G.

    2010-08-05

    Longitudinal and transverse parton distributions for pion and nucleon are calculated from hadron vertexes obtained by a study of form factors within relativistic quark models. The relevance of the one-gluon-exchange dominance at short range for the behavior of the form factors at large momentum transfer and of the parton distributions at the end points is stressed.

  8. Towards a model of pion generalized parton distributions from Dyson-Schwinger equations

    SciTech Connect

    Moutarde, H.

    2015-04-10

    We compute the pion quark Generalized Parton Distribution H{sup q} and Double Distributions F{sup q} and G{sup q} in a coupled Bethe-Salpeter and Dyson-Schwinger approach. We use simple algebraic expressions inspired by the numerical resolution of Dyson-Schwinger and Bethe-Salpeter equations. We explicitly check the support and polynomiality properties, and the behavior under charge conjugation or time invariance of our model. We derive analytic expressions for the pion Double Distributions and Generalized Parton Distribution at vanishing pion momentum transfer at a low scale. Our model compares very well to experimental pion form factor or parton distribution function data.

  9. Transverse-momentum-dependent parton distributions in a spectator diquark model

    SciTech Connect

    F Conti, A Bacchetta, M Radici

    2009-09-01

    Within the framework of a spectator diquark model of the nucleon, involving both scalar and axial-vector diquarks, we calculate all the leading-twist transverse-momentum-dependent parton distribution functions (TMDs). Naive Time-odd densities are generated through a one-gluon-loop rescattering mechanism, simulating the final state interactions required for these functions to exist. Analytic results are obtained for all the TMDs, and a connection with the light-cone wave functions formalism is also established. The model parameters are fixed by reproducing the phenomenological parametrizations of unpolarized and helicity parton distributions at the lowest available scale. Predictions for the other parton densities are given and, whenever possible, compared with available parametrizations.

  10. Diphoton production in the ADD model to NLO + parton shower accuracy at the LHC

    NASA Astrophysics Data System (ADS)

    Frederix, R.; Mandal, Manoj K.; Mathews, Prakash; Ravindran, V.; Seth, Satyajit; Torrielli, P.; Zaro, M.

    2012-12-01

    In this paper, we present the next-to-leading order predictions for diphoton production in the ADD model, matched to the HERWIG parton shower using the MC@NLO formalism. A selection of the results is presented for d = 2-6 extra dimensions, using generic cuts as well as analysis cuts mimicking the search strategies as pursued by the ATLAS and CMS experiments.

  11. PARTON BUBBLE MODEL FOR TWO PARTICLE ANGULAR CORRELATIONS AT RHIC/LHC.

    SciTech Connect

    LINDENBAUM S.J.; LONGACRE, R.S.

    2006-06-27

    In an earlier paper we developed a bubble model, based on a view we had shared with van Hove for over two decades. Namely, that if a quark-gluon plasma is produced in a high energy heavy ion collider, then its hadronization products would likely be emitted from small bubbles localized in phase space containing plasma. In this paper we refined the model to become a parton bubble model in which each localized bubble contains initially 3-4 partons which are almost entirely gluons forming a gluon hot spot. We greatly expanded the transverse momentum interval investigated, and thus are able to treat recombination effects within each bubble. We again utilize two particle correlations as a sensitive method for detecting the average bubble substructure. In this manuscript we make many predictions for angular correlations detectable at RHIC and which will be later modified to LHC conditions. Some early available low precision correlation analyses is qualitatively explained. However a critical consistency test of the model can be made with high precision data expected in the near future.

  12. The description of inclusive characteristics inbar pp interactions at 22.4 GeV/ c in terms of the quark-parton model

    NASA Astrophysics Data System (ADS)

    Batyunya, B. V.; Boguslavsky, I. V.; Gramenitsky, I. M.; Lednický, R.; Levonian, S. V.; Tikhonova, L. A.; Valkárová, A.; Vrba, V.; Zlatanov, Z.; Boos, E. G.; Samoilov, V. V.; Takibaev, Zh. S.; Temiraliev, T.; Lichard, P.; Mašejová, A.; Dumbrajs, S.; Ervanne, J.; Hannula, E.; Villanen, P.; Dementiev, R. K.; Korzhavina, I. A.; Leikin, E. M.; Rud, V. I.; Herynek, I.; Reimer, P.; Řídký, J.; Sedlák, J.; Šimák, V.; Suk, M.; Khudzadze, A. M.; Kuratashvili, G. O.; Topuriya, T. P.; Tzintzadze, V. D.

    1980-03-01

    We compare the inclusive characteristics ofbar pp interactions at 22.4 GeV/ c with quark-parton model predictions in terms of collective variables. The model qualitatively agrees with the data in contradiction to the simple cylindrical phase space and randomized charge model. The ways are proposed of a further development of the quark-parton model.

  13. The CJ12 parton distributions

    SciTech Connect

    Accardi, Alberto; Owens, Jeff F.

    2013-07-01

    Three new sets of next-to-leading order parton distribution functions (PDFs) are presented, determined by global fits to a wide variety of data for hard scattering processes. The analysis includes target mass and higher twist corrections needed for the description of deep-inelastic scattering data at large x and low Q^2, and nuclear corrections for deuterium targets. The PDF sets correspond to three different models for the nuclear effects, and provide a more realistic uncertainty range for the d quark PDF compared with previous fits. Applications to weak boson production at colliders are also discussed.

  14. Nuclear parton distributions and the Drell-Yan process

    NASA Astrophysics Data System (ADS)

    Kulagin, S. A.; Petti, R.

    2014-10-01

    We study the nuclear parton distribution functions on the basis of our recently developed semimicroscopic model, which takes into account a number of nuclear effects including nuclear shadowing, Fermi motion and nuclear binding, nuclear meson-exchange currents, and off-shell corrections to bound nucleon distributions. We discuss in detail the dependencies of nuclear effects on the type of parton distribution (nuclear sea vs valence), as well as on the parton flavor (isospin). We apply the resulting nuclear parton distributions to calculate ratios of cross sections for proton-induced Drell-Yan production off different nuclear targets. We obtain a good agreement on the magnitude, target and projectile x, and the dimuon mass dependence of proton-nucleus Drell-Yan process data from the E772 and E866 experiments at Fermilab. We also provide nuclear corrections for the Drell-Yan data from the E605 experiment.

  15. Charge symmetry at the partonic level

    SciTech Connect

    Londergan, J. T.; Peng, J. C.; Thomas, A. W.

    2010-07-01

    This review article discusses the experimental and theoretical status of partonic charge symmetry. It is shown how the partonic content of various structure functions gets redefined when the assumption of charge symmetry is relaxed. We review various theoretical and phenomenological models for charge symmetry violation in parton distribution functions. We summarize the current experimental upper limits on charge symmetry violation in parton distributions. A series of experiments are presented, which might reveal partonic charge symmetry violation, or alternatively might lower the current upper limits on parton charge symmetry violation.

  16. Parton distribution in pseudoscalar mesons with a light-front constituent quark model

    NASA Astrophysics Data System (ADS)

    de Melo, J. P. B. C.; Ahmed, Isthiaq; Tsushima, Kazuo

    2016-05-01

    We compute the distribution amplitudes of the pion and kaon in the light-front constituent quark model with the symmetric quark-bound state vertex function [1, 2, 3]. In the calculation we explicitly include the flavor-SU(3) symmetry breaking effect in terms of the constituent quark masses of the up (down) and strange quarks. To calculate the kaon parton distribution functions (PDFs), we use both the conditions in the light-cone wave function, i.e., when s ¯ quark is on-shell, and when u quark is on-shell, and make a comparison between them. The kaon PDFs calculated in the two different conditions clearly show asymmetric behaviour due to the flavor SU(3)-symmetry breaking implemented by the quark masses [4, 5].

  17. Access to generalized parton distributions at COMPASS

    SciTech Connect

    Nowak, Wolf-Dieter

    2015-04-10

    A brief experimentalist's introduction to Generalized Parton Distributions (GPDs) is given. Recent COMPASS results are shown on transverse target-spin asymmetries in hard exclusive ρ{sup 0} production and their interpretation in terms of a phenomenological model as indication for chiral-odd, transverse GPDs is discussed. For deeply virtual Compton scattering, it is briefly outlined how to access GPDs and projections are shown for future COMPASS measurements.

  18. Are partons confined tachyons?

    SciTech Connect

    Noyes, H.P.

    1996-03-01

    The author notes that if hadrons are gravitationally stabilized ``black holes``, as discrete physics suggests, it is possible that partons, and in particular quarks, could be modeled as tachyons, i.e. particles having v{sup 2} > c{sup 2}, without conflict with the observational fact that neither quarks nor tachyons have appeared as ``free particles``. Some consequences of this model are explored.

  19. Analysis of pion production data in electron-hadron scattering at JLAB using the TMD Parton Model Formalism

    NASA Astrophysics Data System (ADS)

    Warmate, Tamuno-Negiyeofori; Gamberg, Leonard; Prokudin, Alexei

    2016-09-01

    I have performed a phenomenological analysis of pion production data from Jefferson Laboratory in semi-inclusive deep inelastic scattering of electrons on unpolarized nucleons and deuterium using the transverse momentum dependent (TMD) parton model formalism. We parameterize the data in terms of TMD parton distribution functions that describe the three-dimensional (3-D) partonic structure of the nucleon. One of the main enigmas of data analysis is how to reliably estimate the errors of the parameters that describe some particular physical process. A common method is to use Hessian matrix or vary the delta chi-square of the corresponding fits to the data. In this particular project we use the so-called bootstrap method that is very robust for error estimation. This method has not been extensively used in the description of the TMD distributions that describe the 3-D nucleon structure. The reliable estimate of the errors and thus reliable predictions for future experiments is of great scientific interest. We are using Python and modern methods of data analysis in this project. The results of the project will be useful for understanding the effects of internal motion of quarks and gluons inside of the proton and will be reported in a forthcoming publication.

  20. Investigating strangeness in the proton by studying the effects of Light Cone parton distributions in the Meson Cloud Model

    NASA Astrophysics Data System (ADS)

    Tuppan, Sam; Budnik, Garrett; Fox, Jordan

    2014-09-01

    The Meson Cloud Model (MCM) has proven to be a natural explanation for strangeness in the proton because of meson-baryon splitting into kaon-hyperon pairs. Total strangeness is predicted by integrated splitting functions, which represent the probability that the proton will fluctuate into a given meson-baryon pair. However, the momentum distributions s (x) and s (x) in the proton are determined from convolution integrals that depend on the parton distribution functions (PDFs) used for the mesons and baryons in the MCM. Theoretical calculations of these momentum distributions use many different forms for these PDFs. In our investigation, we calculate PDFs for K, K*, Λ, and Σ from two-body wave functions in a Light Cone Model (LCM) of the hadrons. We use these PDFs in conjunction with the MCM to create a hybrid model and compare our results to other theoretical calculations, experimental data from NuTeV, HERMES, ATLAS, and global parton distribution analyses. The Meson Cloud Model (MCM) has proven to be a natural explanation for strangeness in the proton because of meson-baryon splitting into kaon-hyperon pairs. Total strangeness is predicted by integrated splitting functions, which represent the probability that the proton will fluctuate into a given meson-baryon pair. However, the momentum distributions s (x) and s (x) in the proton are determined from convolution integrals that depend on the parton distribution functions (PDFs) used for the mesons and baryons in the MCM. Theoretical calculations of these momentum distributions use many different forms for these PDFs. In our investigation, we calculate PDFs for K, K*, Λ, and Σ from two-body wave functions in a Light Cone Model (LCM) of the hadrons. We use these PDFs in conjunction with the MCM to create a hybrid model and compare our results to other theoretical calculations, experimental data from NuTeV, HERMES, ATLAS, and global parton distribution analyses. This research has been supported in part by the

  1. Semi-inclusive charged-pion electroproduction off protons and deuterons: Cross sections, ratios, and access to the quark-parton model at low energies

    DOE PAGES

    Asaturyan, R.; Ent, R.; Mkrtchyan, H.; ...

    2012-01-01

    A large set of cross sections for semi-inclusive electroproduction of charged pions (π±) from both proton and deuteron targets was measured. The data are in the deep-inelastic scattering region with invariant mass squared W2 > 4 GeV2 and range in four-momentum transfer squared 2 < Q2 < 4 (GeV/c)2, and cover a range in the Bjorken scaling variable 0.2 < x < 0.6. The fractional energy of the pions spans a range 0.3 < z < 1, with small transverse momenta with respect to the virtual-photon direction, Pt2 < 0.2 (GeV/c)2. The invariant mass that goes undetected, Mx or W',more » is in the nucleon resonance region, W' < 2 GeV. The new data conclusively show the onset of quark-hadron duality in this process, and the relation of this phenomenon to the high-energy factorization ansatz of electron-quark scattering and subsequent quark → pion production mechanisms. The x, z and Pt2 dependences of several ratios (the ratios of favored-unfavored fragmentation functions, charged pion ratios, deuteron-hydrogen and aluminum-deuteron ratios for π+ and π-) have been studied. The ratios are found to be in good agreement with expectations based upon a high-energy quark-parton model description. We find the azimuthal dependences to be small, as compared to exclusive pion electroproduction, and consistent with theoretical expectations based on tree-level factorization in terms of transverse-momentum-dependent parton distribution and fragmentation functions. In the context of a simple model, the initial transverse momenta of d quarks are found to be slightly smaller than for u quarks, while the transverse momentum width of the favored fragmentation function is about the same as for the unfavored one, and both fragmentation widths are larger than the quark widths.« less

  2. Modeling of exclusive parton distributions and long-range rapidity correlations in proton-proton collisions at the LHC energies

    NASA Astrophysics Data System (ADS)

    Kovalenko, V. N.

    2013-10-01

    The soft part of proton-proton interaction is considered within a phenomenological model that involves the formation of color strings. Under the assumption that an elementary collision is associated with the interaction of two color dipoles, the total inelastic cross section and the multiplicity of charged particles are estimated in order to fix model parameters. Particular attention is given to modeling of exclusive parton distributions with allowance for the energy-conservation law and for fixing the center of mass, which are necessary for describing correlations. An algorithm that describes the fusion of strings in the transverse plane and which takes into account their finite rapidity width is developed. The influence of string-fusion effects on long-range correlations is found within this mechanism.

  3. Nuclear Parton Distribution Functions

    SciTech Connect

    Schienbein, I.; Yu, J.-Y.; Keppel, Cynthia; Morfin, Jorge; Olness, F.; Owens, J.F.

    2009-01-01

    We study nuclear effects of charged current deep inelastic neutrino-iron scattering in the framework of a chi^2 analysis of parton distribution functions (PDFs). We extract a set of iron PDFs which are used to compute x_Bj-dependent and Q^2-dependent nuclear correction factors for iron structure functions which are required in global analyses of free nucleon PDFs. We compare our results with nuclear correction factors from neutrino-nucleus scattering models and correction factors for charged-lepton--iron scattering. We find that, except for very high x_Bj, our correction factors differ in both shape and magnitude from the correction factors of the models and charged-lepton scattering.

  4. Nuclear Parton Distribution Functions

    SciTech Connect

    I. Schienbein, J.Y. Yu, C. Keppel, J.G. Morfin, F. Olness, J.F. Owens

    2009-06-01

    We study nuclear effects of charged current deep inelastic neutrino-iron scattering in the framework of a {chi}{sup 2} analysis of parton distribution functions (PDFs). We extract a set of iron PDFs which are used to compute x{sub Bj}-dependent and Q{sup 2}-dependent nuclear correction factors for iron structure functions which are required in global analyses of free nucleon PDFs. We compare our results with nuclear correction factors from neutrino-nucleus scattering models and correction factors for charged-lepton--iron scattering. We find that, except for very high x{sub Bj}, our correction factors differ in both shape and magnitude from the correction factors of the models and charged-lepton scattering.

  5. PACIAE 2.1: An updated issue of the parton and hadron cascade model PACIAE 2.0

    NASA Astrophysics Data System (ADS)

    Sa, Ben-Hao; Zhou, Dai-Mei; Yan, Yu-Liang; Dong, Bao-Guo; Cai, Xu

    2013-05-01

    We have updated the parton and hadron cascade model PACIAE 2.0 (cf. Ben-Hao Sa, Dai-Mei Zhou, Yu-Liang Yan, Xiao-Mei Li, Sheng-Qin Feng, Bao-Guo Dong, Xu Cai, Comput. Phys. Comm. 183 (2012) 333.) to the new issue of PACIAE 2.1. The PACIAE model is based on PYTHIA. In the PYTHIA model, once the hadron transverse momentum pT is randomly sampled in the string fragmentation, the px and py components are originally put on the circle with radius pT randomly. Now it is put on the circumference of ellipse with half major and minor axes of pT(1+δp) and pT(1-δp), respectively, in order to better investigate the final state transverse momentum anisotropy. New version program summaryManuscript title: PACIAE 2.1: An updated issue of the parton and hadron cascade model PACIAE 2.0 Authors: Ben-Hao Sa, Dai-Mei Zhou, Yu-Liang Yan, Bao-Guo Dong, and Xu Cai Program title: PACIAE version 2.1 Journal reference: Catalogue identifier: Licensing provisions: none Programming language: FORTRAN 77 or GFORTRAN Computer: DELL Studio XPS and others with a FORTRAN 77 or GFORTRAN compiler Operating system: Linux or Windows with FORTRAN 77 or GFORTRAN compiler RAM: ≈ 1GB Number of processors used: Supplementary material: Keywords: relativistic nuclear collision; PYTHIA model; PACIAE model Classification: 11.1, 17.8 External routines/libraries: Subprograms used: Catalogue identifier of previous version: aeki_v1_0* Journal reference of previous version: Comput. Phys. Comm. 183(2012)333. Does the new version supersede the previous version?: Yes* Nature of problem: PACIAE is based on PYTHIA. In the PYTHIA model, once the hadron transverse momentum(pT)is randomly sampled in the string fragmentation, thepxandpycomponents are randomly placed on the circle with radius ofpT. This strongly cancels the final state transverse momentum asymmetry developed dynamically. Solution method: Thepxandpycomponent of hadron in the string fragmentation is now randomly placed on the circumference of an ellipse with

  6. Extractions of polarized and unpolarized parton distribution functions

    SciTech Connect

    Jimenez-Delgado, Pedro

    2014-01-01

    An overview of our ongoing extractions of parton distribution functions of the nucleon is given. First JAM results on the determination of spin-dependent parton distribution functions from world data on polarized deep-inelastic scattering are presented first, and followed by a short report on the status of the JR unpolarized parton distributions. Different aspects of PDF analysis are briefly discussed, including effects of the nuclear structure of targets, target-mass corrections and higher twist contributions to the structure functions.

  7. Generalized parton correlation functions for a spin-0 hadron

    SciTech Connect

    Meissner, Stephan; Metz, Andreas; Schlegel, Marc; Goeke, Klaus

    2008-08-01

    The fully unintegrated, off-diagonal quark-quark correlator for a spin-0 hadron is parameterized in terms of so-called generalized parton correlation functions. Such objects are of relevance for the phenomenology of certain hard exclusive reactions. In particular, they can be considered as mother distributions of generalized parton distributions on the one hand and transverse momentum dependent parton distributions on the other. Therefore, our study provides new, model-independent insights into the recently proposed nontrivial relations between generalized and transverse momentum dependent parton distributions. As a by-product we obtain the first complete classification of generalized parton distributions beyond leading twist.

  8. Semi-inclusive charged-pion electroproduction off protons and deuterons: Cross sections, ratios, and access to the quark-parton model at low energies

    SciTech Connect

    Asaturyan, R.; Ent, R.; Mkrtchyan, H.; Navasardyan, T.; Tadevosyan, V.; Adams, G. S.; Ahmidouch, A.; Angelescu, T.; Arrington, J.; Asaturyan, A.; Baker, O. K.; Benmouna, N.; Bertoncini, C.; Blok, H. P.; Boeglin, W. U.; Bosted, P. E.; Breuer, H.; Christy, M. E.; Connell, S. H.; Cui, Y.; Dalton, M. M.; Danagoulian, S.; Day, D.; Dunne, J. A.; Dutta, D.; El Khayari, N.; Fenker, H. C.; Frolov, V. V.; Gan, L.; Gaskell, D.; Hafidi, K.; Hinton, W.; Holt, R. J.; Horn, T.; Huber, G. M.; Hungerford, E.; Jiang, X.; Jones, M.; Joo, K.; Kalantarians, N.; Kelly, J. J.; Keppel, C. E.; Kubarovsky, V.; Li, Y.; Liang, Y.; Mack, D.; Malace, S. P.; Markowitz, P.; McGrath, E.; McKee, P.; Meekins, D. G.; Mkrtchyan, A.; Moziak, B.; Niculescu, G.; Niculescu, I.; Opper, A. K.; Ostapenko, T.; Reimer, P. E.; Reinhold, J.; Roche, J.; Rock, S. E.; Schulte, E.; Segbefia, E.; Smith, C.; Smith, G. R.; Stoler, P.; Tang, L.; Ungaro, M.; Uzzle, A.; Vidakovic, S.; Villano, A.; Vulcan, W. F.; Wang, M.; Warren, G.; Wesselmann, F. R.; Wojtsekhowski, B.; Wood, S. A.; Xu, C.; Yuan, L.; Zheng, X.

    2012-01-01

    A large set of cross sections for semi-inclusive electroproduction of charged pions (π±) from both proton and deuteron targets was measured. The data are in the deep-inelastic scattering region with invariant mass squared W2 > 4 GeV2 and range in four-momentum transfer squared 2 < Q2 < 4 (GeV/c)2, and cover a range in the Bjorken scaling variable 0.2 < x < 0.6. The fractional energy of the pions spans a range 0.3 < z < 1, with small transverse momenta with respect to the virtual-photon direction, Pt2 < 0.2 (GeV/c)2. The invariant mass that goes undetected, Mx or W', is in the nucleon resonance region, W' < 2 GeV. The new data conclusively show the onset of quark-hadron duality in this process, and the relation of this phenomenon to the high-energy factorization ansatz of electron-quark scattering and subsequent quark → pion production mechanisms. The x, z and Pt2 dependences of several ratios (the ratios of favored-unfavored fragmentation functions, charged pion ratios, deuteron-hydrogen and aluminum-deuteron ratios for π+ and π-) have been studied. The ratios are found to be in good agreement with expectations based upon a high-energy quark-parton model description. We find the azimuthal dependences to be small, as compared to exclusive pion electroproduction, and consistent with theoretical expectations based on tree-level factorization in terms of transverse-momentum-dependent parton distribution and fragmentation functions. In the context of a simple model, the initial transverse momenta of d quarks are found to be slightly smaller than for u quarks, while the transverse momentum width of the favored fragmentation function is about the same as for the unfavored one, and both fragmentation widths are larger than the quark widths.

  9. Unraveling hadron structure with generalized parton distributions

    SciTech Connect

    Andrei Belitsky; Anatoly Radyushkin

    2004-10-01

    The recently introduced generalized parton distributions have emerged as a universal tool to describe hadrons in terms of quark and gluonic degrees of freedom. They combine the features of form factors, parton densities and distribution amplitudes - the functions used for a long time in studies of hadronic structure. Generalized parton distributions are analogous to the phase-space Wigner quasi-probability function of non-relativistic quantum mechanics which encodes full information on a quantum-mechanical system. We give an extensive review of main achievements in the development of this formalism. We discuss physical interpretation and basic properties of generalized parton distributions, their modeling and QCD evolution in the leading and next-to-leading orders. We describe how these functions enter a wide class of exclusive reactions, such as electro- and photo-production of photons, lepton pairs, or mesons.

  10. From many body wee partons dynamics to perfect fluid: a standard model for heavy ion collisions

    SciTech Connect

    Venugopalan, R.

    2010-07-22

    We discuss a standard model of heavy ion collisions that has emerged both from experimental results of the RHIC program and associated theoretical developments. We comment briefly on the impact of early results of the LHC program on this picture. We consider how this standard model of heavy ion collisions could be solidified or falsified in future experiments at RHIC, the LHC and a future Electro-Ion Collider.

  11. Parton shower Monte Carlo event generators

    NASA Astrophysics Data System (ADS)

    Webber, Bryan

    2011-12-01

    A parton shower Monte Carlo event generator is a computer program designed to simulate the final states of high-energy collisions in full detail down to the level of individual stable particles. The aim is to generate a large number of simulated collision events, each consisting of a list of final-state particles and their momenta, such that the probability to produce an event with a given list is proportional (approximately) to the probability that the corresponding actual event is produced in the real world. The Monte Carlo method makes use of pseudorandom numbers to simulate the event-to-event fluctuations intrinsic to quantum processes. The simulation normally begins with a hard subprocess, shown as a black blob in Figure 1, in which constituents of the colliding particles interact at a high momentum scale to produce a few outgoing fundamental objects: Standard Model quarks, leptons and/or gauge or Higgs bosons, or hypothetical particles of some new theory. The partons (quarks and gluons) involved, as well as any new particles with colour, radiate virtual gluons, which can themselves emit further gluons or produce quark-antiquark pairs, leading to the formation of parton showers (brown). During parton showering the interaction scale falls and the strong interaction coupling rises, eventually triggering the process of hadronization (yellow), in which the partons are bound into colourless hadrons. On the same scale, the initial-state partons in hadronic collisions are confined in the incoming hadrons. In hadron-hadron collisions, the other constituent partons of the incoming hadrons undergo multiple interactions which produce the underlying event (green). Many of the produced hadrons are unstable, so the final stage of event generation is the simulation of the hadron decays.

  12. Connected-Sea Partons

    NASA Astrophysics Data System (ADS)

    Liu, Keh-Fei; Chang, Wen-Chen; Cheng, Hai-Yang; Peng, Jen-Chieh

    2012-12-01

    According to the path-integral formalism of the hadronic tensor, the nucleon sea contains two distinct components called the connected sea (CS) and the disconnected sea (DS). We discuss how the CS and DS are accessed in the lattice QCD calculation of the moments of the parton distributions. We show that the CS and DS components of u¯(x)+d¯(x) can be extracted by using recent data on the strangeness parton distribution, the CT10 global fit, and the lattice result of the ratio of the strange to u(d) moments in the disconnected insertion. The extracted CS and DS for u¯(x)+d¯(x) have a distinct Bjorken x dependence in qualitative agreement with expectation. The analysis also shows that the momentum fraction of u¯(x)+d¯(x) is about equally divided between the CS and DS at Q2=2.5GeV2. Implications for the future global analysis of parton distributions are presented.

  13. Multiple parton scattering in nuclei: Parton energy loss

    SciTech Connect

    Wang, Xin-Nian; Guo, Xiao-feng

    2001-02-17

    Multiple parton scattering and induced parton energy loss are studied in deeply inelastic scattering (DIS) off nuclei. The effect of multiple scattering of a highly off-shell quark and the induced parton energy loss is expressed in terms of the modification to the quark fragmentation functions. The authors derive such modified quark fragmentation functions and their QCD evolution equations in DIS using the generalized factorization of higher twist parton distributions. They consider double-hard and hard-soft parton scattering as well as their interferences in the same framework. The final result, which depends on both the diagonal and off-diagonal twist-four parton distributions in nuclei, demonstrates clearly the Landau-Pomeranchuk-Migdal interference features and predicts a unique nuclear modification of the quark fragmentation functions.

  14. Structure functions in the polarized Drell-Yan processes with spin-1/2 and spin-1 hadrons. II. Parton model

    NASA Astrophysics Data System (ADS)

    Hino, S.; Kumano, S.

    1999-09-01

    We analyze the polarized Drell-Yan processes with spin-1/2 and spin-1 hadrons in a parton model. Quark and antiquark correlation functions are expressed in terms of possible combinations of Lorentz vectors and pseudovectors with the constrains of Hermiticity, parity conservation, and time-reversal invariance. Then, we find tensor-polarized distributions for a spin-1 hadron. The naive parton model predicts that there exist 19 structure functions. However, there are only four or five nonvanishing structure functions, depending on whether the cross section is integrated over the virtual-photon transverse momentum Q-->T or the limit QT-->0 is taken. One of the finite structure functions is related to the tensor-polarized distribution b1, and it does not exist in the proton-proton reactions. The vanishing structure functions should be associated with higher-twist physics. The tensor distributions can be measured by the quadrupole polarization measurements. The Drell-Yan process has an advantage over the lepton reaction in the sense that the antiquark tensor polarization could be extracted rather easily.

  15. Generalized parton distributions from deep virtual compton scattering at CLAS

    DOE PAGES

    Guidal, M.

    2010-04-24

    Here, we have analyzed the beam spin asymmetry and the longitudinally polarized target spin asymmetry of the Deep Virtual Compton Scattering process, recently measured by the Jefferson Lab CLAS collaboration. Our aim is to extract information about the Generalized Parton Distributions of the proton. By fitting these data, in a largely model-independent procedure, we are able to extract numerical values for the two Compton Form Factorsmore » $$H_{Im}$$ and $$\\tilde{H}_{Im}$$ with uncertainties, in average, of the order of 30%.« less

  16. Dynamics of hot and dense nuclear and partonic matter

    SciTech Connect

    Bratkovskaya, E. L.; Cassing, W.; Linnyk, O.; Konchakovski, V. P.; Voronyuk, V.; Ozvenchuk, V.

    2012-06-15

    The dynamics of hot and dense nuclear matter is discussed from the microscopic transport point of view. The basic concepts of the Hadron-String-Dynamical transport model (HSD)-derived from Kadanoff-Baym equations in phase phase-are presented as well as 'highlights' of HSD results for different observables in heavy-ion collisions from 100 A MeV (SIS) to 21 A TeV(RHIC) energies. Furthermore, a novel extension of the HSD model for the description of the partonic phase-the Parton-Hadron-String-Dynamics (PHSD) approach-is introduced. PHSD includes a nontrivial partonic equation of state-in line with lattice QCD-as well as covariant transition rates from partonic to hadronic degrees of freedom. The sensitivity of hadronic observables to the partonic phase is demonstrated for relativistic heavy-ion collisions from the FAIR/NICA up to the RHIC energy regime.

  17. Unintegrated double parton distributions - A summary

    NASA Astrophysics Data System (ADS)

    Golec-Biernat, Krzysztof; Staśto, Anna

    2017-03-01

    We present main elements of the construction of unintegrated double parton distribution functions which depend on transverse momenta of partons. We follow the method proposed by Kimber, Martin and Ryskin for a construction of unintegrated single parton distributions from the standard parton distribution functions.

  18. Nonperturbative evolution of parton quasi-distributions

    NASA Astrophysics Data System (ADS)

    Radyushkin, A. V.

    2017-04-01

    Using the formalism of parton virtuality distribution functions (VDFs) we establish a connection between the transverse momentum dependent distributions (TMDs) F (x , k⊥2) and quasi-distributions (PQDs) Q (y ,p3) introduced recently by X. Ji for lattice QCD extraction of parton distributions f (x). We build models for PQDs from the VDF-based models for soft TMDs, and analyze the p3 dependence of the resulting PQDs. We observe a strong nonperturbative evolution of PQDs for small and moderately large values of p3 reflecting the transverse momentum dependence of TMDs. Thus, the study of PQDs on the lattice in the domain of strong nonperturbative effects opens a new perspective for investigation of the 3-dimensional hadron structure.

  19. Strongly interacting parton matter equilibration

    SciTech Connect

    Ozvenchuk, V.; Linnyk, O.; Bratkovskaya, E.; Gorenstein, M.; Cassing, W.

    2012-07-15

    We study the kinetic and chemical equilibration in 'infinite' parton matter within the Parton-Hadron-String Dynamics transport approach. The 'infinite' matter is simulated within a cubic box with periodic boundary conditions initialized at different energy densities. Particle abundances, kinetic energy distributions, and the detailed balance of the off-shell quarks and gluons in the strongly-interacting quarkgluon plasma are addressed and discussed.

  20. Strongly interacting parton matter equilibration

    NASA Astrophysics Data System (ADS)

    Ozvenchuk, V.; Linnyk, O.; Bratkovskaya, E.; Gorenstein, M.; Cassing, W.

    2012-07-01

    We study the kinetic and chemical equilibration in "infinite" parton matter within the Parton-Hadron-String Dynamics transport approach. The "infinite" matter is simulated within a cubic box with periodic boundary conditions initialized at different energy densities. Particle abundances, kinetic energy distributions, and the detailed balance of the off-shell quarks and gluons in the strongly-interacting quarkgluon plasma are addressed and discussed.

  1. New parton distributions from large-x and low-Q2 data

    SciTech Connect

    Alberto Accardi; Christy, M. Eric; Keppel, Cynthia E.; Melnitchouk, Wally; Monaghan, Peter A.; Morfin, Jorge G.; Owens, Joseph F.

    2010-02-11

    We report results of a new global next-to-leading order fit of parton distribution functions in which cuts on W and Q are relaxed, thereby including more data at high values of x. Effects of target mass corrections (TMCs), higher twist contributions, and nuclear corrections for deuterium data are significant in the large-x region. The leading twist parton distributions are found to be stable to TMC model variations as long as higher twist contributions are also included. Furthermore, the behavior of the d quark as x → 1 is particularly sensitive to the deuterium corrections, and using realistic nuclear smearing models the d-quark distribution at large x is found to be softer than in previous fits performed with more restrictive cuts.

  2. Momentum transfer dependence of generalized parton distributions

    NASA Astrophysics Data System (ADS)

    Sharma, Neetika

    2016-11-01

    We revisit the model for parametrization of the momentum dependence of nucleon generalized parton distributions in the light of recent MRST measurements of parton distribution functions (A.D. Martin et al., Eur. Phys. J. C 63, 189 (2009)). Our parametrization method with a minimum set of free parameters give a sufficiently good description of data for Dirac and Pauli electromagnetic form factors of proton and neutron at small and intermediate values of momentum transfer. We also calculate the GPDs for up- and down-quarks by decomposing the electromagnetic form factors for the nucleon using the charge and isospin symmetry and also study the evolution of GPDs to a higher scale. We further investigate the transverse charge densities for both the unpolarized and transversely polarized nucleon and compare our results with Kelly's distribution.

  3. Dynamical equilibration of strongly interacting ``infinite'' parton matter within the parton-hadron-string dynamics transport approach

    NASA Astrophysics Data System (ADS)

    Ozvenchuk, V.; Linnyk, O.; Gorenstein, M. I.; Bratkovskaya, E. L.; Cassing, W.

    2013-02-01

    We study the kinetic and chemical equilibration in “infinite” parton matter within the parton-hadron-string dynamics off-shell transport approach, which is based on a dynamical quasiparticle model (DQPM) for partons matched to reproduce lattice QCD results—including the partonic equation of state—in thermodynamic equilibrium. The “infinite” parton matter is simulated by a system of quarks and gluons within a cubic box with periodic boundary conditions, at various energy densities, initialized out of kinetic and chemical equilibrium. We investigate the approach of the system to equilibrium and the time scales for the equilibration of different observables. We, furthermore, study particle distributions in the strongly interacting quark-gluon plasma (sQGP) including partonic spectral functions, momentum distributions, abundances of the different parton species, and their fluctuations (scaled variance, skewness, and kurtosis) in equilibrium. We also compare the results of the microscopic calculations with the ansatz of the DQPM. It is found that the results of the transport calculations are in equilibrium well matched by the DQPM for quarks and antiquarks, while the gluon spectral function shows a slightly different shape due to the mass dependence of the gluon width generated by the explicit interactions of partons. The time scales for the relaxation of fluctuation observables are found to be shorter than those for the average values. Furthermore, in the local subsystem, a strong change of the fluctuation observables with the size of the local volume is observed. These fluctuations no longer correspond to those of the full system and are reduced to Poissonian distributions when the volume of the local subsystem becomes small.

  4. Medium Effects in Parton Distributions

    SciTech Connect

    William Detmold, Huey-Wen Lin

    2011-12-01

    A defining experiment of high-energy physics in the 1980s was that of the EMC collaboration where it was first observed that parton distributions in nuclei are non-trivially related to those in the proton. This result implies that the presence of the nuclear medium plays an important role and an understanding of this from QCD has been an important goal ever since Here we investigate analogous, but technically simpler, effects in QCD and examine how the lowest moment of the pion parton distribution is modified by the presence of a Bose-condensed gas of pions or kaons.

  5. Summing threshold logs in a parton shower

    NASA Astrophysics Data System (ADS)

    Nagy, Zoltán; Soper, Davison E.

    2016-10-01

    When parton distributions are falling steeply as the momentum fractions of the partons increases, there are effects that occur at each order in α s that combine to affect hard scattering cross sections and need to be summed. We show how to accomplish this in a leading approximation in the context of a parton shower Monte Carlo event generator.

  6. Cosmic ray air shower characteristics in the framework of the parton-based Gribov-Regge model NEXUS

    NASA Astrophysics Data System (ADS)

    Bossard, G.; Drescher, H. J.; Kalmykov, N. N.; Ostapchenko, S.; Pavlov, A. I.; Pierog, T.; Vishnevskaya, E. A.; Werner, K.

    2001-03-01

    The purpose of this paper is twofold: first we want to introduce a new type of hadronic interaction model (NEXUS), which has a much more solid theoretical basis than, for example, presently used models such as QGSJET and VENUS, and ensures therefore a much more reliable extrapolation towards high energies. Secondly, we want to promote an extensive air shower (EAS) calculation scheme, based on cascade equations rather than explicit Monte Carlo simulations, which is very accurate in calculations of main EAS characteristics and extremely fast concerning computing time. We employ the NEXUS model to provide the necessary data on particle production in hadron-air collisions and present the average EAS characteristics for energies 1014-1017 eV. The experimental data of the CASA-BLANCA group are analyzed in the framework of the new model.

  7. First moments of nucleon generalized parton distributions

    SciTech Connect

    Wang, P.; Thomas, A. W.

    2010-06-01

    We extrapolate the first moments of the generalized parton distributions using heavy baryon chiral perturbation theory. The calculation is based on the one loop level with the finite range regularization. The description of the lattice data is satisfactory, and the extrapolated moments at physical pion mass are consistent with the results obtained with dimensional regularization, although the extrapolation in the momentum transfer to t=0 does show sensitivity to form factor effects, which lie outside the realm of chiral perturbation theory. We discuss the significance of the results in the light of modern experiments as well as QCD inspired models.

  8. QCD next-to-leading-order predictions matched to parton showers for vector-like quark models

    NASA Astrophysics Data System (ADS)

    Fuks, Benjamin; Shao, Hua-Sheng

    2017-02-01

    Vector-like quarks are featured by a wealth of beyond the Standard Model theories and are consequently an important goal of many LHC searches for new physics. Those searches, as well as most related phenomenological studies, however, rely on predictions evaluated at the leading-order accuracy in QCD and consider well-defined simplified benchmark scenarios. Adopting an effective bottom-up approach, we compute next-to-leading-order predictions for vector-like-quark pair production and single production in association with jets, with a weak or with a Higgs boson in a general new physics setup. We additionally compute vector-like-quark contributions to the production of a pair of Standard Model bosons at the same level of accuracy. For all processes under consideration, we focus both on total cross sections and on differential distributions, most these calculations being performed for the first time in our field. As a result, our work paves the way to precise extraction of experimental limits on vector-like quarks thanks to an accurate control of the shapes of the relevant observables and emphasise the extra handles that could be provided by novel vector-like-quark probes never envisaged so far.

  9. Generalized parton distributions in nuclei

    SciTech Connect

    Vadim Guzey

    2009-12-01

    Generalized parton distributions (GPDs) of nuclei describe the distribution of quarks and gluons in nuclei probed in hard exclusive reactions, such as e.g. deeply virtual Compton scattering (DVCS). Nuclear GPDs and nuclear DVCS allow us to study new aspects of many traditional nuclear effects (nuclear shadowing, EMC effect, medium modifications of the bound nucleons) as well as to access novel nuclear effects. In my talk, I review recent theoretical progress in the area of nuclear GPDs.

  10. Structure functions and parton distributions

    SciTech Connect

    Martin, A.D.; Stirling, W.J.; Roberts, R.G.

    1995-07-01

    The MRS parton distribution analysis is described. The latest sets are shown to give an excellent description of a wide range of deep-inelastic and other hard scattering data. Two important theoretical issues-the behavior of the distributions at small x and the flavor structure of the quark sea-are discussed in detail. A comparison with the new structure function data from HERA is made, and the outlook for the future is discussed.

  11. Generalized parton distributions and Deeply Virtual Compton Scattering on proton at CLAS

    SciTech Connect

    R. De Masi

    2007-12-01

    Two measurements of target and beam spin asymmetries for the reaction ep→epγ were performed with CLAS at Jefferson Laboratory. Polarized 5.7 GeV electrons were impinging on a longitudinally polarized ammonia and liquid hydrogen target respectively. These measurements are sensitive to Generalized Parton Distributions. Sizable sin phi azimuthal angular dependences were observed in both experiments, indicating the dominance of leading twist terms and the possibility of extracting combinations of Generalized Parton Distributions on the nucleon.

  12. Emergent phenomena and partonic structure in hadrons

    NASA Astrophysics Data System (ADS)

    Roberts, Craig D.; Mezrag, Cédric

    2017-03-01

    Modern facilities are poised to tackle fundamental questions within the Standard Model, aiming to reveal the nature of confinement, its relationship to dynamical chiral symmetry breaking (DCSB) - the origin of visible mass - and the connection between these two, key emergent phenomena. There is strong evidence to suggest that they are intimately connected with the appearance of momentum-dependent masses for gluons and quarks in QCD, which are large in the infrared: mg 500MeV and Mq 350MeV. DCSB, expressed in the dynamical generation of a dressed-quark mass, has an enormous variety of verifiable consequences, including an enigmatic result that the properties of the (almost) massless pion are the cleanest expression of the mechanism which is responsible for almost all the visible mass in the Universe. This contribution explains that these emergent phenomena are expressed with particular force in the partonic structure of hadrons, e.g. in valence-quark parton distribution amplitudes and functions, and, consequently, in numerous hadronic observables, so that we are now in a position to exhibit the consequences of confinement and DCSB in a wide range of hadron observables, opening the way to empirical verification of their expression in the Standard Model.

  13. Generalized parton correlation functions for a spin-1/2 hadron

    SciTech Connect

    Stephan Meissner, Andreas Metz, Marc Schlegel

    2009-08-01

    The fully unintegrated, off-diagonal quark-quark correlator for a spin-1/2 hadron is parameterized in terms of so-called generalized parton correlation functions. Such objects, in particular, can be considered as mother distributions of generalized parton distributions on the one hand and transverse momentum dependent parton distributions on the other. Therefore, our study provides new, model-independent insights into the recently proposed nontrivial relations between generalized and transverse momentum dependent parton distributions. We find that none of these relations can be promoted to a model-independent status. As a by-product we obtain the first complete classification of generalized parton distributions beyond leading twist. The present paper is a natural extension of our previous corresponding analysis for spin-0 hadrons.

  14. Deeply Virtual Exclusive Processes and Generalized Parton Distributions

    SciTech Connect

    ,

    2011-06-01

    The goal of the comprehensive program in Deeply Virtual Exclusive Scattering at Jefferson Laboratory is to create transverse spatial images of quarks and gluons as a function of their longitudinal momentum fraction in the proton, the neutron, and in nuclei. These functions are the Generalized Parton Distributions (GPDs) of the target nucleus. Cross section measurements of the Deeply Virtual Compton Scattering (DVCS) reaction ep {yields} ep{gamma} in Hall A support the QCD factorization of the scattering amplitude for Q^2 {>=} 2 GeV^2. Quasi-free neutron-DVCS measurements on the Deuteron indicate sensitivity to the quark angular momentum sum rule. Fully exclusive H(e, e'p{gamma} ) measurements have been made in a wide kinematic range in CLAS with polarized beam, and with both unpolarized and longitudinally polarized targets. Existing models are qualitatively consistent with the JLab data, but there is a clear need for less constrained models. Deeply virtual vector meson production is studied in CLAS. The 12 GeV upgrade will be essential for for these channels. The {rho} and {omega} channels reactions offer the prospect of flavor sensitivity to the quark GPDs, while the {phi}-production channel is dominated by the gluon distribution.

  15. Nuclear modifications of Parton Distribution Functions

    NASA Astrophysics Data System (ADS)

    Adeluyi, Adeola Adeleke

    -called shadowing region. We also investigate the effects of nuclear modifications on observed quantities in ultrarelativistic nucleus-nucleus collisions. Specifically, we consider deuteron-gold collisions and observables which are directly impacted by modifications, such as pseudorapidity asymmetry and nuclear modification factors. A good description of the shadowing region is afforded by Gribov Theory. Gribov related the shadowing correction to the differential diffractive hadron-nucleon cross section. We generalize Gribov theory to include both the real part of the diffractive scattering amplitude and higher order multiple scattering necessary for heavy nuclei. The diffractive dissociation inputs are taken from experiments. We calculate observables in deuteron-gold collisions. Utilizing the factorization theorem, we use the existing parameterizations of nuclear PDFs and fragmentation functions in a pQCD-improved parton model to calculate nuclear modification factors and pseudorapidity asymmetries. The nuclear modification factor is essentially the ratio of the deuteron-gold cross section to that of the proton-proton cross section scaled by the number of binary collisions. The pseudorapidity asymmetry is the ratio of the cross section in the negative rapidity region relative to that in the equivalent positive rapidity region. Both quantities are sensitive to the effects of nuclear modifications on PDFs. Results are compared to experimental data from the BRAHMS and STAR collaborations.

  16. Parton interpretation of the nucleon spin-dependent structure functions

    SciTech Connect

    Mankiewicz, L. ); Ryzak, Z. )

    1991-02-01

    We discuss the interpretation of the nucleon's polarized structure function {ital g}{sub 2}({ital x}). If the target state is represented by its Fock decomposition on the light cone, the operator-product expansion allows us to demonstrate that moments of {ital g}{sub 2}({ital x}) are related to overlap integrals between wave functions of opposite longitudinal polarizations. In the light-cone formalism such wave functions are related by the kinematical operator {ital scrY}, or light-cone parity. As a consequence, it can be shown that moments of {ital g}{sub 2} give information about the same parton wave function, or probability amplitude to find a certain parton configuration in the target which defines {ital g}{sub 1}({ital x}) or {ital F}{sub 2}({ital x}). Specific formulas are given, and possible applications to the phenomenology of the nucleon structure in QCD are discussed.

  17. The parton distribution function library

    SciTech Connect

    Plothow-Besch, H.

    1995-07-01

    This article describes an integrated package of Parton Density Functions called PDFLIB which has been added to the CERN Program Library Pool W999 and is labelled as W5051. In this package all the different sets of parton density functions of the Nucleon, Pion and the Photon which are available today have been put together. All these sets have been combined in a consistent way such that they all have similar calling sequences and no external data files have to be read in anymore. A default set has been prepared, although those preferring their own set or wanting to test a new one may do so within the package. The package also offers a program to calculate the strong coupling constant {alpha}, to first or second order. The correct {Lambda}{sub QCD} associated to the selected set of structure functions and the number of allowed flavours with respect to the given Q{sup 2} is automatically used in the calculation. The selection of sets, the program parameters as well as the possibilities to modify the defaults and to control errors occurred during execution are described.

  18. Higher twist parton distributions from light-cone wave functions

    SciTech Connect

    Braun, V. M.; Lautenschlager, T.; Pirnay, B.; Manashov, A. N.

    2011-05-01

    We explore the possibility to construct higher-twist parton distributions in a nucleon at some low reference scale from convolution integrals of the light-cone wave functions (WFs). To this end we introduce simple models for the four-particle nucleon WFs involving three valence quarks and a gluon with total orbital momentum zero, and estimate their normalization (WF at the origin) using QCD sum rules. We demonstrate that these WFs provide one with a reasonable description of both polarized and unpolarized parton densities at large values of the Bjorken variable x{>=}0.5. Twist-three parton distributions are then constructed as convolution integrals of qqqg and the usual three-quark WFs. The cases of the polarized structure function g{sub 2}(x,Q{sup 2}) and single transverse spin asymmetries are considered in detail. We find that the so-called gluon pole contribution to twist-three distributions relevant for single spin asymmetry vanishes in this model, but is generated perturbatively at higher scales by the evolution, in the spirit of Glueck-Reya-Vogt parton distributions.

  19. Jet correlations from unintegrated parton distributions

    SciTech Connect

    Hautmann, F.; Jung, H.

    2008-10-13

    Transverse-momentum dependent parton distributions can be introduced gauge-invariantly in QCD from high-energy factorization. We discuss Monte Carlo applications of these distributions to parton showers and jet physics, with a view to the implications for the Monte Carlo description of complex hadronic final states with multiple hard scales at the LHC.

  20. DETAILED COMPARISON BETWEEN PARTON CASCADE AND HADRONIC CASCADE AT SPS AND RHIC.

    SciTech Connect

    NARA,Y.

    1998-10-23

    The authors study the importance of the partonic phase produced in relativistic heavy ion collision by comparing the parton cascade model and the hadronic cascade model. Hadron yield, baryon stopping and transverse momentum distribution are calculated with JAM and discussions are given comparing with VNI. Both of these models give good description of experimental data. They also discuss the strangeness production mechanism and the directed transverse flow.

  1. Air target models for fuzing simulations

    NASA Astrophysics Data System (ADS)

    Dammann, J. F., Jr.

    1982-09-01

    Radar backscatter models for air targets suitable for computer simulation of radar fuze-air target encounters are described. These models determine the characteristics of the energy reflected to the fuze when the target is illuminated by a fuze radar. When the target models are coupled with fuze models, the time when the fuze detects the presence of the target can be determined for any arbitrary terminal encounter geometry. Fuze detection times for representative trajectories can be compared with fuze specifications to measure fuze performance or can be used as a part of a simulation of an entire system to determine system performance. Following one basic methodology, target models have been written for the Fishbed, Foxbat, and Flogger fighter aircraft; the Hind-D helicopter; and the Backfire, Blinder, and B-1 bombers. All of the models are specular point models where the major return is assumed to come from a small number of glitter points or specular points on the target.

  2. Jet Hadronization via Recombination of Parton Showers in Vacuum and in Medium

    NASA Astrophysics Data System (ADS)

    Fries, Rainer J.; Han, Kyongchol; Ko, Che Ming

    2016-12-01

    We introduce a hadronization algorithm for jet parton showers based on a hybrid approach involving recombination of quarks and fragmentation of strings. The algorithm can be applied to parton showers from a shower Monte Carlo generator at the end of their perturbative evolution. The algorithm forces gluon decays and then evaluates the recombination probabilities for quark-antiquark pairs into mesons and (anti)quark triplets into (anti)baryons. We employ a Wigner phase space formulation based on the assumption of harmonic oscillator wave functions for stable hadrons and resonances. Partons too isolated in phase space to find recombination partners are connected by QCD strings to other quarks. Fragmentation of those remnant strings and the decay of all hadron resonances complete the hadronization process. We find that our model applied to parton showers from the PYTHIA Monte Carlo event generator leads to results very similar to pure Lund string fragmentation. We suggest that our algorithm can be readily generalized to jets embedded in quark-gluon plasma by adding sampled thermal partons from the phase transition hypersurface. The recombination of thermal partons and shower partons leads to an enhancement of pions and protons at intermediate momentum at both RHIC and LHC.

  3. Working Group I: Parton distributions: Summary report for the HERA LHC Workshop Proceedings

    SciTech Connect

    Dittmar, M.; Forte, S.; Glazov, A.; Moch, S.; Alekhin, S.; Altarelli, G.; Andersen, Jeppe R.; Ball, R.D.; Blumlein, J.; Bottcher, H.; Carli, T.; Ciafaloni, M.; Colferai, D.; Cooper-Sarkar, A.; Corcella, G.; Del Debbio, L.; Dissertori, G.; Feltesse, J.; Guffanti, A.; Gwenlan, C.; Huston, J.; /Zurich, ETH /DESY, Zeuthen /Serpukhov, IHEP /CERN /Rome III U. /INFN, Rome3 /Cambridge U. /Edinburgh U. /Florence U. /INFN, Florence /Oxford U. /DSM, DAPNIA, Saclay /Michigan State U. /Uppsala U. /Barcelona U., ECM /Podgorica U. /Turin U. /INFN, Turin /Harish-Chandra Res. Inst. /Fermilab /Hamburg U., Inst. Theor. Phys. II

    2005-11-01

    We provide an assessment of the impact of parton distributions on the determination of LHC processes, and of the accuracy with which parton distributions (PDFs) can be extracted from data, in particular from current and forthcoming HERA experiments. We give an overview of reference LHC processes and their associated PDF uncertainties, and study in detail W and Z production at the LHC.We discuss the precision which may be obtained from the analysis of existing HERA data, tests of consistency of HERA data from different experiments, and the combination of these data. We determine further improvements on PDFs which may be obtained from future HERA data (including measurements of F{sub L}), and from combining present and future HERA data with present and future hadron collider data. We review the current status of knowledge of higher (NNLO) QCD corrections to perturbative evolution and deep-inelastic scattering, and provide reference results for their impact on parton evolution, and we briefly examine non-perturbative models for parton distributions. We discuss the state-of-the art in global parton fits, we assess the impact on them of various kinds of data and of theoretical corrections, by providing benchmarks of Alekhin and MRST parton distributions and a CTEQ analysis of parton fit stability, and we briefly presents proposals for alternative approaches to parton fitting. We summarize the status of large and small x resummation, by providing estimates of the impact of large x resummation on parton fits, and a comparison of different approaches to small x resummation, for which we also discuss numerical techniques.

  4. First JAM results on the determination of polarized parton distributions

    SciTech Connect

    Accardi, Alberto; Jimenez-Delgado, Pedro; Melnitchouk, Wally

    2014-01-01

    The Jefferson Lab Angular Momentum (JAM) Collaboration is a new initiative to study the angular momentum dependent structure of the nucleon. First results on the determination of spin-dependent parton distribution functions at intermediate and large x from world data on polarized deep-inelastic scattering are presented. Different aspects of global QCD analysis are discussed, including the effects of nuclear structure of deuterium and {sup 3}He targets, target mass corrections and higher twist contributions to the g{sub 1} and g{sub 2} structure functions.

  5. Pre-equilibrium parton dynamics: Proceedings

    SciTech Connect

    Wang, Xin-Nian

    1993-12-31

    This report contains papers on the following topics: parton production and evolution; QCD transport theory; interference in the medium; QCD and phase transition; and future heavy ion experiments. This papers have been indexed separately elsewhere on the data base.

  6. A Review of Target Mass Corrections

    SciTech Connect

    I. Schienbein; V. Radescu; G. Zeller; M. E. Christy; C. E. Keppel; K. S. McFarland; W. Melnitchouk; F. I. Olness; M. H. Reno; F. Steffens; J.-Y. Yu

    2007-09-06

    With recent advances in the precision of inclusive lepton-nuclear scattering experiments, it has become apparent that comparable improvements are needed in the accuracy of the theoretical analysis tools. In particular, when extracting parton distribution functions in the large-x region, it is crucial to correct the data for effects associated with the nonzero mass of the target. We present here a comprehensive review of these target mass corrections (TMC) to structure functions data, summarizing the relevant formulas for TMCs in electromagnetic and weak processes. We include a full analysis of both hadronic and partonic masses, and trace how these effects appear in the operator product expansion and the factorized parton model formalism, as well as their limitations when applied to data in the x -> 1 limit. We evaluate the numerical effects of TMCs on various structure functions, and compare fits to data with and without these corrections.

  7. Q2-DEPENDENCE of the Statistical Parton Distributions in the Valon Approach

    NASA Astrophysics Data System (ADS)

    Sohaily, S.; Yazdanpanah, M. M.; Mirjalili, A.

    2012-06-01

    We employ the statistical approach to obtain the nucleon parton distributions. Statistical distributions are considered as well for partons in the valon model in which a nucleon is assumed to be a state of three valence quark clusters (valon). Analytic expressions of the x-dependent of parton distribution functions (PDFs) in the valon model are obtained statistically in the whole x region [0, 1] in terms of the statistical parameters such as temperature, chemical potential and accessible volume. Since PDFs are obtained by taking the required sum rules including Gottfried sum rule at different energy scales, the Q2-dependence of these parameters can be obtained. Therefore the parton distributions as a function of Q2 will be resulted. To make the calculations more precise, we extend our results to contain three flavors rather than two light u and d quarks.

  8. The midpoint between dipole and parton showers

    SciTech Connect

    Höche, Stefan; Prestel, Stefan

    2015-09-28

    We present a new parton-shower algorithm. Borrowing from the basic ideas of dipole cascades, the evolution variable is judiciously chosen as the transverse momentum in the soft limit. This leads to a very simple analytic structure of the evolution. A weighting algorithm is implemented that allows one to consistently treat potentially negative values of the splitting functions and the parton distributions. Thus, we provide two independent, publicly available implementations for the two event generators PYTHIA and SHERPA.

  9. Transverse-momentum-dependent parton distributions (TMDs)

    SciTech Connect

    Bacchetta, Alessandro

    2011-10-24

    Transverse-momentum-dependent parton distributions (TMDs) provide three-dimensional images of the partonic structure of the nucleon in momentum space. We made impressive progress in understanding TMDs, both from the theoretical and experimental point of view. This brief overview on TMDs is divided in two parts: in the first, an essential list of achievements is presented. In the second, a selection of open questions is discussed.

  10. Parton distributions with LHC data

    NASA Astrophysics Data System (ADS)

    Ball, Richard D.; Bertone, Valerio; Carrazza, Stefano; Deans, Christopher S.; Del Debbio, Luigi; Forte, Stefano; Guffanti, Alberto; Hartland, Nathan P.; Latorre, José I.; Rojo, Juan; Ubiali, Maria; Nnpdf Collaboration

    2013-02-01

    We present the first determination of parton distributions of the nucleon at NLO and NNLO based on a global data set which includes LHC data: NNPDF2.3. Our data set includes, besides the deep inelastic, Drell-Yan, gauge boson production and jet data already used in previous global PDF determinations, all the relevant LHC data for which experimental systematic uncertainties are currently available: ATLAS and LHCb W and Z rapidity distributions from the 2010 run, CMS W electron asymmetry data from the 2011 run, and ATLAS inclusive jet cross-sections from the 2010 run. We introduce an improved implementation of the FastKernel method which allows us to fit to this extended data set, and also to adopt a more effective minimization methodology. We present the NNPDF2.3 PDF sets, and compare them to the NNPDF2.1 sets to assess the impact of the LHC data. We find that all the LHC data are broadly consistent with each other and with all the older data sets included in the fit. We present predictions for various standard candle cross-sections, and compare them to those obtained previously using NNPDF2.1, and specifically discuss the impact of ATLAS electroweak data on the determination of the strangeness fraction of the proton. We also present collider PDF sets, constructed using only data from HERA, the Tevatron and the LHC, but find that this data set is neither precise nor complete enough for a competitive PDF determination.

  11. Nuclear effects on tetraquark production by double parton scattering

    NASA Astrophysics Data System (ADS)

    Carvalho, F.; Navarra, F. S.

    2017-03-01

    In this work we study the nuclear effects in exotic meson production. We estimate the total cross section as a function of the energy for pPb scattering using a version of the color evaporation model (CEM) adapted to Double Parton Scattering (DPS). We fond that the cross section grows significantly with the atomic number, indicating that the hypothesis of tetraquark states can be tested in pA collisions at LHC.

  12. Transverse nucleon structure and diagnostics of hard parton-parton processes at LHC

    SciTech Connect

    L. Frankfurt, M. Strikman, C. Weiss

    2011-03-01

    We propose a new method to determine at what transverse momenta particle production in high-energy pp collisions is governed by hard parton-parton processes. Using information on the transverse spatial distribution of partons obtained from hard exclusive processes in ep/\\gamma p scattering, we evaluate the impact parameter distribution of pp collisions with a hard parton-parton process as a function of p_T of the produced parton (jet). We find that the average pp impact parameters in such events depend very weakly on p_T in the range 2 < p_T < few 100 GeV, while they are much smaller than those in minimum-bias inelastic collisions. The impact parameters in turn govern the observable transverse multiplicity in such events (in the direction perpendicular to the trigger particle or jet). Measuring the transverse multiplicity as a function of p_T thus provides an effective tool for determining the minimum p_T for which a given trigger particle originates from a hard parton-parton process.

  13. First JAM results on the determination of polarized parton distributions

    SciTech Connect

    Jimenez-Delgado, Pedro

    2013-04-01

    The Jefferson Lab Angular Momentum (JAM) collaboration is a new initiative aimed to the study of the angular-momentum-dependent structure of the nucleon. First results on the determination of spin-dependent parton distribution functions from world data on polarized deep-inelastic scattering will be presented and compared with previous determinations from other groups. Different aspects of global QCD analysis will be discussed, including effects due to nuclear structure, higher twist, and target-mass corrections, as well as the impact of different data selections.

  14. Computational modeling of foveal target detection.

    PubMed

    Witus, Gary; Ellis, R Darin

    2003-01-01

    This paper presents the VDM2000, a computational model of target detection designed for use in military developmental test and evaluation settings. The model integrates research results from the fields of early vision, object recognition, and psychophysics. The VDM2000 is image based and provides a criterion-independent measure of target conspicuity, referred to as the vehicle metric (VM). A large data set of human responses to photographs of military vehicles in a field setting was used to validate the model. The VM adjusted by a single calibration parameter accounts for approximately 80% of the variance in the validation data. The primary application of this model is to predict detection of military targets in daylight with the unaided eye. The model also has application to target detection prediction using infrared night vision systems. The model has potential as a tool to evaluate the visual properties of more general task settings.

  15. Nucleon Parton Structure from Continuum QCD

    NASA Astrophysics Data System (ADS)

    Bednar, Kyle; Cloet, Ian; Tandy, Peter

    2017-01-01

    The parton structure of the nucleon is investigated using QCD's Dyson-Schwinger equations (DSEs). This formalism builds in numerous essential features of QCD, for example, the dressing of parton propagators and dynamical formation of non-pointlike di-quark correlations. All needed elements of the approach, including the nucleon wave function solution from a Poincaré covariant Faddeev equation, are encoded in spectral-type representations in the Nakanishi style. This facilitates calculations and the necessary connections between Euclidean and Minkowski metrics. As a first step results for the nucleon quark distribution functions will be presented. The extension to the transverse momentum-dependent parton distributions (TMDs) also be discussed. Supported by NSF Grant No. PHY-1516138.

  16. Constraints on parton distribution from CDF

    SciTech Connect

    Bodek, A.; CDF Collaboration

    1995-10-01

    The asymmetry in W{sup -} - W{sup +} production in p{bar p} collisions and Drell-Yan data place tight constraints on parton distributions functions. The W asymmetry data constrain the slope of the quark distribution ratio d(x)/u(x) in the x range 0.007-0.27. The published W asymmetry results from the CDF 1992.3 data ({approx} 20 pb{sup -1}) greatly reduce the systematic error originating from the choice of PDF`s in the W mass measurement at CDF. These published results have also been included in the CTEQ3, MRSA, and GRV94 parton distribution fits. These modern parton distribution functions axe still in good agreement with the new 1993-94 CDF data({approx} 108 pb{sup -1} combined). Preliminary results from CDF for the Drell-Yan cross section in the mass range 11-350 GeV/c{sup 2} are discussed.

  17. New limits on intrinsic charm in the nucleon from global analysis of parton distributions

    DOE PAGES

    Jimenez-Delgado, P.; Hobbs, T. J.; Londergan, J. T.; ...

    2015-02-27

    We present a new global QCD analysis of parton distribution functions, allowing for possible intrinsic charm (IC) contributions in the nucleon inspired by light-front models. The analysis makes use of the full range of available high-energy scattering data for Q2 ≥ 1 GeV2 and W2 ≥ 3.5 GeV2, including fixed-target proton and deuteron deep cross sections at lower energies that were excluded in previously global analyses. The expanded data set places more stringent constraints on the momentum carried by IC, with (x)IC at most 0.5% (corresponding to an IC normalization of ~1%) at the 4σ level for ΔX2 = 1.more » We also assess the impact of older EMC measurements of Fc2c at large x, which favor a nonzero IC, but with very large X2 values.« less

  18. Parton Propagation and Fragmentation in QCD Matter

    SciTech Connect

    Alberto Accardi, Francois Arleo, William Brooks, David D'Enterria, Valeria Muccifora

    2009-12-01

    We review recent progress in the study of parton propagation, interaction and fragmentation in both cold and hot strongly interacting matter. Experimental highlights on high-energy hadron production in deep inelastic lepton-nucleus scattering, proton-nucleus and heavy-ion collisions, as well as Drell-Yan processes in hadron-nucleus collisions are presented. The existing theoretical frameworks for describing the in-medium interaction of energetic partons and the space-time evolution of their fragmentation into hadrons are discussed and confronted to experimental data. We conclude with a list of theoretical and experimental open issues, and a brief description of future relevant experiments and facilities.

  19. Evolution of parton fragmentation functions at finitetemperature

    SciTech Connect

    Osborne, Jonathan; Wang, Enke; Wang, Xin-Nian

    2002-06-12

    The first order correction to the parton fragmentation functions in a thermal medium is derived in the leading logarithmic approximation in the framework of thermal field theory. The medium-modified evolution equations of the parton fragmentation functions are also derived. It is shown that all infrared divergences, both linear and logarithmic, in the real processes are canceled among themselves and by corresponding virtual corrections. The evolution of the quark number and the energy loss (or gain) induced by the thermal medium are investigated.

  20. Perturbative QCD correlations in multi-parton collisions

    NASA Astrophysics Data System (ADS)

    Blok, B.; Dokshitzer, Yu.; Frankfurt, L.; Strikman, M.

    2014-06-01

    We examine the role played in double-parton interactions (DPI) by the parton-parton correlations originating from perturbative QCD parton splittings. Also presented are the results of the numerical analysis of the integrated DPI cross sections at Tevatron and LHC energies. To obtain the numerical results the knowledge of the single-parton GPDs gained by the HERA experiments was used to construct the non-perturbative input for generalized double-parton distributions. The perturbative two-parton correlations induced by three-parton interactions contribute significantly to a resolution of the longstanding puzzle of an excess of multi-jet production events in the back-to-back kinematics observed at the Tevatron.

  1. Fragmentation of parton jets at small x

    SciTech Connect

    Kirschner, R.

    1985-08-01

    The parton fragmentation function is calculated in the region of small x in the doubly logarithmic approximation of QCD. For this, the method of separating the softest particle, which has hitherto been applied only in the Regge kinematic region, is developed. Simple arguments based on unitarity and gauge invariance are used to derive the well known condition of ordering of the emission angles.

  2. Progress in the dynamical parton distributions

    SciTech Connect

    Jimenez-Delgado, Pedro

    2012-06-01

    The present status of the (JR) dynamical parton distribution functions is reported. Different theoretical improvements, including the determination of the strange sea input distribution, the treatment of correlated errors and the inclusion of alternative data sets, are discussed. Highlights in the ongoing developments as well as (very) preliminary results in the determination of the strong coupling constant are presented.

  3. Systematic Improvement of QCD Parton Showers

    SciTech Connect

    Winter, Jan; Hoeche, Stefan; Hoeth, Hendrik; Krauss, Frank; Schonherr, Marek; Zapp, Korinna; Schumann, Steffen; Siegert, Frank; /Freiburg U.

    2012-05-17

    In this contribution, we will give a brief overview of the progress that has been achieved in the field of combining matrix elements and parton showers. We exemplify this by focusing on the case of electron-positron collisions and by reporting on recent developments as accomplished within the SHERPA event generation framework.

  4. Generalized Parton Distributions: Visions, Basics, and Realities

    NASA Astrophysics Data System (ADS)

    Müller, D.

    2014-06-01

    An introductory to generalized parton distributions (GDPs) is given which emphasizes their spectral property and its uses as well as the equivalence of various GDP representations. Furthermore, the status of the theory and phenomenology of hard exclusive processes is shortly reviewed.

  5. Probe initial parton density and formation time via jet quenching

    SciTech Connect

    Wang, Xin-Nian

    2002-09-20

    Medium modification of jet fragmentation function due to multiple scattering and induced gluon radiation leads directly to jet quenching or suppression of leading particle distribution from jet fragmentation. One can extract an effective total parton energy loss which can be related to the total transverse momentum broadening. For an expanding medium, both are shown to be sensitive to the initial parton density and formation time. Therefore, one can extract the initial parton density and formation time from simultaneous measurements of parton energy loss and transverse momentum broadening. Implication of the recent experimental data on effects of detailed balance in parton energy loss is also discussed.

  6. Statistical modeling of single target cell encapsulation.

    PubMed

    Moon, SangJun; Ceyhan, Elvan; Gurkan, Umut Atakan; Demirci, Utkan

    2011-01-01

    High throughput drop-on-demand systems for separation and encapsulation of individual target cells from heterogeneous mixtures of multiple cell types is an emerging method in biotechnology that has broad applications in tissue engineering and regenerative medicine, genomics, and cryobiology. However, cell encapsulation in droplets is a random process that is hard to control. Statistical models can provide an understanding of the underlying processes and estimation of the relevant parameters, and enable reliable and repeatable control over the encapsulation of cells in droplets during the isolation process with high confidence level. We have modeled and experimentally verified a microdroplet-based cell encapsulation process for various combinations of cell loading and target cell concentrations. Here, we explain theoretically and validate experimentally a model to isolate and pattern single target cells from heterogeneous mixtures without using complex peripheral systems.

  7. Modeling target erosion during reactive sputtering

    NASA Astrophysics Data System (ADS)

    Strijckmans, K.; Depla, D.

    2015-03-01

    The influence of the reactive sputter conditions on the racetrack and the sputter profile for an Al/O2 DC reactive sputter system is studied by modeling. The role of redeposition, i.e. the deposition of sputtered material back on the target, is therefore taken into account. The used model RSD2013 is capable of simulating the effect of redeposition on the target condition in a spatial resolved way. Comparison between including and excluding redeposition in the RSD2013 model shows that the in-depth oxidation profile of the target differs. Modeling shows that it is important to distinguish between the formed racetrack, i.e. the erosion depth profile, and the sputter profile. The latter defines the distribution of the sputtered atoms in the vacuum chamber. As the target condition defines the sputter yield, it does determine the racetrack and the sputter profile of the planar circular target. Both the shape of the racetrack and the sputter profile change as function of the redeposition fraction as well as function of the oxygen flow change. Clear asymmetries and narrowing are observed for the racetrack shape. Similar effects are noticed for the sputter profile but to a different extent. Based on this study, the often heard misconception that the racetrack shape defines the distribution of the sputtered atoms during reactive sputtering is proven to be wrong.

  8. Intrinsic transverse momentum and parton correlations from dynamical chiral symmetry breaking

    SciTech Connect

    Peter Schweitzer, Mark Strikman, Christian Weiss

    2013-01-01

    The dynamical breaking of chiral symmetry in QCD is caused by nonperturbative interactions on a distance scale rho ~ 0.3 fm, much smaller than the typical hadronic size R ~ 1 fm. These short-distance interactions influence the intrinsic transverse momentum distributions of partons and their correlations at a low normalization point. We study this phenomenon in an effective description of the low-energy dynamics in terms of chiral constituent quark degrees of freedom, which refers to the large-N_c limit of QCD. The nucleon is obtained as a system of constituent quarks and antiquarks moving in a self-consistent classical chiral field (relativistic mean-field approximation, or chiral quark-soliton model). The calculated transverse momentum distributions of constituent quarks and antiquarks are matched with QCD quarks, antiquarks and gluons at the chiral symmetry--breaking scale rho^{-2}. We find that the transverse momentum distribution of valence quarks is localized at p_T^2 ~ R^{-2} and roughly of Gaussian shape. The distribution of unpolarized sea quarks exhibits a would-be power-like tail ~1/p_T^2 extending up to the chiral symmetry-breaking scale. Similar behavior is observed in the flavor-nonsinglet polarized sea. The high-momentum tails are the result of short-range correlations between sea quarks in the nucleon's light-cone wave function, which are analogous to short-range NN correlations in nuclei. We show that the nucleon's light-cone wave function contains correlated pairs of transverse size rho << R with scalar-isoscalar (Sigma) and pseudoscalar-isovector (Pi) quantum numbers, whose internal wave functions have a distinctive spin structure and become identical at p_T^2 ~ rho^{-2} (restoration of chiral symmetry). These features are model-independent and represent an effect of dynamical chiral symmetry breaking on the nucleon's partonic structure. Our results have numerous implications for the transverse momentum distributions of particles produced in hard

  9. Time series modeling for automatic target recognition

    NASA Astrophysics Data System (ADS)

    Sokolnikov, Andre

    2012-05-01

    Time series modeling is proposed for identification of targets whose images are not clearly seen. The model building takes into account air turbulence, precipitation, fog, smoke and other factors obscuring and distorting the image. The complex of library data (of images, etc.) serving as a basis for identification provides the deterministic part of the identification process, while the partial image features, distorted parts, irrelevant pieces and absence of particular features comprise the stochastic part of the target identification. The missing data approach is elaborated that helps the prediction process for the image creation or reconstruction. The results are provided.

  10. Studies of transverse momentum dependent parton distributions and Bessel weighting

    SciTech Connect

    Aghasyan, M.; Avakian, H.; De Sanctis, E.; Gamberg, L.; Mirazita, M.; Musch, B.; Prokudin, A.; Rossi, P.

    2015-03-01

    In this paper we present a new technique for analysis of transverse momentum dependent parton distribution functions, based on the Bessel weighting formalism. The procedure is applied to studies of the double longitudinal spin asymmetry in semi-inclusive deep inelastic scattering using a new dedicated Monte Carlo generator which includes quark intrinsic transverse momentum within the generalized parton model. Using a fully differential cross section for the process, the effect of four momentum conservation is analyzed using various input models for transverse momentum distributions and fragmentation functions. We observe a few percent systematic offset of the Bessel-weighted asymmetry obtained from Monte Carlo extraction compared to input model calculations, which is due to the limitations imposed by the energy and momentum conservation at the given energy/Q2. We find that the Bessel weighting technique provides a powerful and reliable tool to study the Fourier transform of TMDs with controlled systematics due to experimental acceptances and resolutions with different TMD model inputs.

  11. Studies of transverse momentum dependent parton distributions and Bessel weighting

    DOE PAGES

    Aghasyan, M.; Avakian, H.; De Sanctis, E.; ...

    2015-03-01

    In this paper we present a new technique for analysis of transverse momentum dependent parton distribution functions, based on the Bessel weighting formalism. The procedure is applied to studies of the double longitudinal spin asymmetry in semi-inclusive deep inelastic scattering using a new dedicated Monte Carlo generator which includes quark intrinsic transverse momentum within the generalized parton model. Using a fully differential cross section for the process, the effect of four momentum conservation is analyzed using various input models for transverse momentum distributions and fragmentation functions. We observe a few percent systematic offset of the Bessel-weighted asymmetry obtained from Montemore » Carlo extraction compared to input model calculations, which is due to the limitations imposed by the energy and momentum conservation at the given energy/Q2. We find that the Bessel weighting technique provides a powerful and reliable tool to study the Fourier transform of TMDs with controlled systematics due to experimental acceptances and resolutions with different TMD model inputs.« less

  12. Examining the Crossover from the Hadronic to Partonic Phase in QCD

    SciTech Connect

    Xu Mingmei; Yu Meiling; Liu Lianshou

    2008-03-07

    A mechanism, consistent with color confinement, for the transition between perturbative and physical vacua during the gradual crossover from the hadronic to partonic phase is proposed. The essence of this mechanism is the appearance and growing up of a kind of grape-shape perturbative vacuum inside the physical one. A percolation model based on simple dynamics for parton delocalization is constructed to exhibit this mechanism. The crossover from hadronic matter to sQGP (strongly coupled quark-gluon plasma) as well as the transition from sQGP to weakly coupled quark-gluon plasma with increasing temperature is successfully described by using this model.

  13. Generalized parton distributions and exclusive processes

    SciTech Connect

    Guzey, Vadim

    2013-10-01

    In last fifteen years, GPDs have emerged as a powerful tool to reveal such aspects of the QCD structure of the nucleon as: - 3D parton correlations and distributions; - spin content of the nucleon. Further advances in the field of GPDs and hard exclusive processes rely on: - developments in theory and new methods in phenomenology such as new flexible parameterizations, neural networks, global QCD fits - new high-precision data covering unexplored kinematics: JLab at 6 and 12 GeV, Hermes with recoil detector, Compass, EIC. This slide-show presents: Nucleon structure in QCD, particularly hard processes, factorization and parton distributions; and a brief overview of GPD phenomenology, including basic properties of GPDs, GPDs and QCD structure of the nucleon, and constraining GPDs from experiments.

  14. Parton distribution benchmarking with LHC data

    NASA Astrophysics Data System (ADS)

    Ball, Richard D.; Carrazza, Stefano; Del Debbio, Luigi; Forte, Stefano; Gao, Jun; Hartland, Nathan; Huston, Joey; Nadolsky, Pavel; Rojo, Juan; Stump, Daniel; Thorne, Robert S.; Yuan, C.-P.

    2013-04-01

    We present a detailed comparison of the most recent sets of NNLO PDFs from the ABM, CT, HERAPDF, MSTW and NNPDF collaborations. We compare parton distributions at low and high scales and parton luminosities relevant for LHC phenomenology. We study the PDF dependence of LHC benchmark inclusive cross sections and differential distributions for electroweak boson and jet production in the cases in which the experimental covariance matrix is available. We quantify the agreement between data and theory by computing the χ 2 for each data set with all the various PDFs. PDF comparisons are performed consistently for common values of the strong coupling. We also present a benchmark comparison of jet production at the LHC, comparing the results from various available codes and scale settings. Finally, we discuss the implications of the updated NNLO PDF sets for the combined PDF+ α s uncertainty in the gluon fusion Higgs production cross section.

  15. Model-based target and background characterization

    NASA Astrophysics Data System (ADS)

    Mueller, Markus; Krueger, Wolfgang; Heinze, Norbert

    2000-07-01

    Up to now most approaches of target and background characterization (and exploitation) concentrate solely on the information given by pixels. In many cases this is a complex and unprofitable task. During the development of automatic exploitation algorithms the main goal is the optimization of certain performance parameters. These parameters are measured during test runs while applying one algorithm with one parameter set to images that constitute of image domains with very different domain characteristics (targets and various types of background clutter). Model based geocoding and registration approaches provide means for utilizing the information stored in GIS (Geographical Information Systems). The geographical information stored in the various GIS layers can define ROE (Regions of Expectations) and may allow for dedicated algorithm parametrization and development. ROI (Region of Interest) detection algorithms (in most cases MMO (Man- Made Object) detection) use implicit target and/or background models. The detection algorithms of ROIs utilize gradient direction models that have to be matched with transformed image domain data. In most cases simple threshold calculations on the match results discriminate target object signatures from the background. The geocoding approaches extract line-like structures (street signatures) from the image domain and match the graph constellation against a vector model extracted from a GIS (Geographical Information System) data base. Apart from geo-coding the algorithms can be also used for image-to-image registration (multi sensor and data fusion) and may be used for creation and validation of geographical maps.

  16. Biological models for automatic target detection

    NASA Astrophysics Data System (ADS)

    Schachter, Bruce

    2008-04-01

    Humans are better at detecting targets in literal imagery than any known algorithm. Recent advances in modeling visual processes have resulted from f-MRI brain imaging with humans and the use of more invasive techniques with monkeys. There are four startling new discoveries. 1) The visual cortex does not simply process an incoming image. It constructs a physics based model of the image. 2) Coarse category classification and range-to-target are estimated quickly - possibly through the dorsal pathway of the visual cortex, combining rapid coarse processing of image data with expectations and goals. This data is then fed back to lower levels to resize the target and enhance the recognition process feeding forward through the ventral pathway. 3) Giant photosensitive retinal ganglion cells provide data for maintaining circadian rhythm (time-of-day) and modeling the physics of the light source. 4) Five filter types implemented by the neurons of the primary visual cortex have been determined. A computer model for automatic target detection has been developed based upon these recent discoveries. It uses an artificial neural network architecture with multiple feed-forward and feedback paths. Our implementation's efficiency derives from the observation that any 2-D filter kernel can be approximated by a sum of 2-D box functions. And, a 2-D box function easily decomposes into two 1-D box functions. Further efficiency is obtained by decomposing the largest neural filter into a high pass filter and a more sparsely sampled low pass filter.

  17. Correlations in double parton distributions: perturbative and non-perturbative effects

    NASA Astrophysics Data System (ADS)

    Rinaldi, Matteo; Scopetta, Sergio; Traini, Marco; Vento, Vicente

    2016-10-01

    The correct description of Double Parton Scattering (DPS), which represents a background in several channels for the search of new Physics at the LHC, requires the knowledge of double parton distribution functions (dPDFs). These quantities represent also a novel tool for the study of the three-dimensional nucleon structure, complementary to the possibilities offered by electromagnetic probes. In this paper we analyze dPDFs using Poincaré covariant predictions obtained by using a Light-Front constituent quark model proposed in a recent paper, and QCD evolution. We study to what extent factorized expressions for dPDFs, which neglect, at least in part, two-parton correlations, can be used. We show that they fail in reproducing the calculated dPDFs, in particular in the valence region. Actually measurable processes at existing facilities occur at low longitudinal momenta of the interacting partons; to have contact with these processes we have analyzed correlations between pairs of partons of different kind, finding that, in some cases, they are strongly suppressed at low longitudinal momenta, while for other distributions they can be sizeable. For example, the effect of gluon-gluon correlations can be as large as 20 %. We have shown that these behaviors can be understood in terms of a delicate interference of non-perturbative correlations, generated by the dynamics of the model, and perturbative ones, generated by the model independent evolution procedure. Our analysis shows that at LHC kinematics two-parton correlations can be relevant in DPS, and therefore we address the possibility to study them experimentally.

  18. Long-range azimuthal correlations in proton–proton and proton–nucleus collisions from the incoherent scattering of partons

    SciTech Connect

    Ma, Guo -Liang; Bzdak, Adam

    2014-11-04

    In this study, we show that the incoherent elastic scattering of partons, as present in a multi-phase transport model (AMPT), with a modest parton–parton cross-section of σ = 1.5 – 3 mb, naturally explains the long-range two-particle azimuthal correlation as observed in proton–proton and proton–nucleus collisions at the Large Hadron Collider.

  19. Target & Propagation Models for the FINDER Radar

    NASA Technical Reports Server (NTRS)

    Cable, Vaughn; Lux, James; Haque, Salmon

    2013-01-01

    Finding persons still alive in piles of rubble following an earthquake, a severe storm, or other disaster is a difficult problem. JPL is currently developing a victim detection radar called FINDER (Finding Individuals in Emergency and Response). The subject of this paper is directed toward development of propagation & target models needed for simulation & testing of such a system. These models are both physical (real rubble piles) and numerical. Early results from the numerical modeling phase show spatial and temporal spreading characteristics when signals are passed through a randomly mixed rubble pile.

  20. Evolutionary Drift Models for Moving Target Defense

    SciTech Connect

    Oehmen, Christopher S.; Peterson, Elena S.; Teuton, Jeremy R.

    2012-10-31

    One of the biggest challenges faced by cyber defenders is that attacks evolve more rapidly than our ability to recognize them. We propose a moving target defense concept in which the means of detection is set in motion. This is done by moving away from static signature-based detection and instead adopting biological modeling techniques that describe families of related sequences. We present here one example for how to apply evolutionary models to cyber sequences, and demonstrate the feasibility of this technique on analysis of a complex, evolving software project. Specifically, we applied sequence-based and profile-based evolutionary models and report the ability of these models to recognize highly volatile code regions. We found that different drift models reliably identify different types of evolutionarily related code regions. The impact is that these (and possibly other) evolutionary models could be used in a moving target defense in which the "signature" being used to detect sequence-based behaviors is not a fixed signature but one that can recognize new variants of a known family based on multiple evolutionary models.

  1. Termites as targets and models for biotechnology.

    PubMed

    Scharf, Michael E

    2015-01-07

    Termites have many unique evolutionary adaptations associated with their eusocial lifestyles. Recent omics research has created a wealth of new information in numerous areas of termite biology (e.g., caste polyphenism, lignocellulose digestion, and microbial symbiosis) with wide-ranging applications in diverse biotechnological niches. Termite biotechnology falls into two categories: (a) termite-targeted biotechnology for pest management purposes, and (b) termite-modeled biotechnology for use in various industrial applications. The first category includes several candidate termiticidal modes of action such as RNA interference, digestive inhibition, pathogen enhancement, antimicrobials, endocrine disruption, and primer pheromone mimicry. In the second category, termite digestomes are deep resources for host and symbiont lignocellulases and other enzymes with applications in a variety of biomass, industrial, and processing applications. Moving forward, one of the most important approaches for accelerating advances in both termite-targeted and termite-modeled biotechnology will be to consider host and symbiont together as a single functional unit.

  2. From Bethe-Salpeter Wave functions to Generalised Parton Distributions

    NASA Astrophysics Data System (ADS)

    Mezrag, C.; Moutarde, H.; Rodríguez-Quintero, J.

    2016-09-01

    We review recent works on the modelling of generalised parton distributions within the Dyson-Schwinger formalism. We highlight how covariant computations, using the impulse approximation, allows one to fulfil most of the theoretical constraints of the GPDs. Specific attention is brought to chiral properties and especially the so-called soft pion theorem, and its link with the Axial-Vector Ward-Takahashi identity. The limitation of the impulse approximation are also explained. Beyond impulse approximation computations are reviewed in the forward case. Finally, we stress the advantages of the overlap of lightcone wave functions, and possible ways to construct covariant GPD models within this framework, in a two-body approximation.

  3. Studies of partonic transverse momentum and spin structure of the nucleon

    NASA Astrophysics Data System (ADS)

    Contalbrigo, M.

    2014-06-01

    The investigation of the partonic degrees of freedom beyond collinear approximation (3D description) has been gained increasing interest in the last decade. The Thomas Jefferson National Laboratory, after the CEBAF upgrade to 12 GeV, will become the most complete facility for the investigation of the hadron structure in the valence region by scattering of polarized electron off various polarized nucleon targets. A compendium of the planned experiments is here presented.

  4. Excited nucleon as a van der Waals system of partons

    SciTech Connect

    Jenkovszky, L. L.; Muskeyev, A. O. Yezhov, S. N.

    2012-06-15

    Saturation in deep inelastic scattering (DIS) and deeply virtual Compton scattering (DVCS) is associated with a phase transition between the partonic gas, typical of moderate x and Q{sup 2}, and partonic fluid appearing at increasing Q{sup 2} and decreasing Bjorken x. We suggest the van der Waals equation of state to describe properly this phase transition.

  5. Nucleon Generalized Parton Distributions from Full Lattice QCD

    SciTech Connect

    Robert Edwards; Philipp Haegler; David Richards; John Negele; Konstantinos Orginos; Wolfram Schroers; Jonathan Bratt; Andrew Pochinsky; Michael Engelhardt; George Fleming; Bernhard Musch; Dru Renner

    2007-07-03

    We present a comprehensive study of the lowest moments of nucleon generalized parton distributions in N_f=2+1 lattice QCD using domain wall valence quarks and improved staggered sea quarks. Our investigation includes helicity dependent and independent generalized parton distributions for pion masses as low as 350 MeV and volumes as large as (3.5 fm)^3.

  6. Parton physics from large-momentum effective field theory

    NASA Astrophysics Data System (ADS)

    Ji, XiangDong

    2014-07-01

    Parton physics, when formulated as light-front correlations, are difficult to study non-perturbatively, despite the promise of light-front quantization. Recently an alternative approach to partons have been proposed by re-visiting original Feynman picture of a hadron moving at asymptotically large momentum. Here I formulate the approach in the language of an effective field theory for a large hadron momentum P in lattice QCD, LaMET for short. I show that using this new effective theory, parton properties, including light-front parton wave functions, can be extracted from lattice observables in a systematic expansion of 1/ P, much like that the parton distributions can be extracted from the hard scattering data at momentum scales of a few GeV.

  7. Parton Charge Symmetry Violation: Electromagnetic Effects and W Production Asymmetries

    SciTech Connect

    J.T. Londergan; D.P. Murdock; A.W. Thomas

    2006-04-14

    Recent phenomenological work has examined two different ways of including charge symmetry violation in parton distribution functions. First, a global phenomenological fit to high energy data has included charge symmetry breaking terms, leading to limits on the magnitude of parton charge symmetry breaking. In a second approach, two groups have included the coupling of partons to photons in the QCD evolution equations. One possible experiment that could search for isospin violation in parton distributions is a measurement of the asymmetry in W production at a collider. In this work we include both of the postulated sources of parton charge symmetry violation. We show that, given charge symmetry violation of a magnitude consistent with existing high energy data, the expected W production asymmetries would be quite small, generally less than one percent.

  8. Deeply exclusive processes and generalized parton distributions

    SciTech Connect

    Marc Vanderhaegen

    2005-02-01

    We discuss how generalized parton distributions (GPDs) enter into hard exclusive processes, and focuses on the links between GPDs and elastic nucleon form factors. These links, in the form of sum rules, represent powerful constraints on parameterizations of GPDs. A Regge parameterization for the GPDs at small momentum transfer -t is extended to the large-t region and it is found to catch the basic features of proton and neutron electromagnetic form factor data. This parameterization allows to estimate the quark contribution to the nucleon spin. It is furthermore discussed how these GPDs at large-t enter into two-photon exchange processes and resolve the discrepancy between Rosenbluth and polarization experiments of elastic electron nucleon scattering.

  9. Parton distributions in nuclei: Quagma or quagmire

    SciTech Connect

    Close, F.E.

    1988-01-01

    The emerging information on the way quark, antiquark, and gluon distributions are modified in nuclei relative to free nucleons is reviewed. Particular emphasis is placed on Drell-Yan and /psi/ production on nuclei and caution against premature use of these as signals for quagma in heavy-ion collisions. If we are to identify the formation of quark-gluon plasma in heavy-ion collisions by changes in the production rates for /psi/ relative to Drell-Yan lepton pairs, then it is important that we first understand the ''intrinsic'' changes in parton distributions in nuclei relative to free nucleons. So, emerging knowledge on how quark, antiquark, and gluon distributions are modified in nuclei relative to free nucleons is reviewed, and the emerging theoretical concensus is briefly summarized.

  10. Quasi parton distributions and the gradient flow

    DOE PAGES

    Monahan, Christopher; Orginos, Kostas

    2017-03-22

    We propose a new approach to determining quasi parton distribution functions (PDFs) from lattice quantum chromodynamics. By incorporating the gradient flow, this method guarantees that the lattice quasi PDFs are finite in the continuum limit and evades the thorny, and as yet unresolved, issue of the renormalization of quasi PDFs on the lattice. In the limit that the flow time is much smaller than the length scale set by the nucleon momentum, the moments of the smeared quasi PDF are proportional to those of the lightfront PDF. Finally, we use this relation to derive evolution equations for the matching kernelmore » that relates the smeared quasi PDF and the light-front PDF.« less

  11. Rapid Target Modeling Through Genetic Inheritance Mechanism Genetically Evolved Target Prototypmg (GETP). Phase I

    DTIC Science & Technology

    1996-12-10

    Phase I Final Report Rapid Target Modeling Through Genetic Inheritance Mechanism Genetically Evolved Target Prototyping (GETP) Pbiai Dat December 10...COVERED 12/10/96 Final Report 5/7/96-12/10/96 A. TITE AND SUBTITU S. FUNDING NUMBERS Rapid Target Modeling Through Genetic Inheritance Mechanism... Genetically Evolved Target Prototyping (GETP) 6. AUTHOR(S) Dr. Jerzy Bala (P1) Dr. Peter Pachowicz (Co-P1) B.K. Gogia (PM) 7. PERFORMING ORGANIZATION

  12. Ballistic protons in incoherent exclusive vector meson production as a measure of rare parton fluctuations at an electron-ion collider

    DOE PAGES

    Lappi, T.; Venugopalan, R.; Mantysaari, H.

    2015-02-25

    We argue that the proton multiplicities measured in Roman pot detectors at an electron ion collider can be used to determine centrality classes in incoherent diffractive scattering. Incoherent diffraction probes the fluctuations in the interaction strengths of multi-parton Fock states in the nuclear wavefunctions. In particular, the saturation scale that characterizes this multi-parton dynamics is significantly larger in central events relative to minimum bias events. As an application, we examine the centrality dependence of incoherent diffractive vector meson production. We identify an observable which is simultaneously very sensitive to centrality triggered parton fluctuations and insensitive to details of the model.

  13. On the internal target model in a tracking task

    NASA Technical Reports Server (NTRS)

    Caglayan, A. K.; Baron, S.

    1981-01-01

    An optimal control model for predicting operator's dynamic responses and errors in target tracking ability is summarized. The model, which predicts asymmetry in the tracking data, is dependent on target maneuvers and trajectories. Gunners perception, decision making, control, and estimate of target positions and velocity related to crossover intervals are discussed. The model provides estimates for means, standard deviations, and variances for variables investigated and for operator estimates of future target positions and velocities.

  14. Target Recognition Using Neural Networks for Model Deformation Measurements

    NASA Technical Reports Server (NTRS)

    Ross, Richard W.; Hibler, David L.

    1999-01-01

    Optical measurements provide a non-invasive method for measuring deformation of wind tunnel models. Model deformation systems use targets mounted or painted on the surface of the model to identify known positions, and photogrammetric methods are used to calculate 3-D positions of the targets on the model from digital 2-D images. Under ideal conditions, the reflective targets are placed against a dark background and provide high-contrast images, aiding in target recognition. However, glints of light reflecting from the model surface, or reduced contrast caused by light source or model smoothness constraints, can compromise accurate target determination using current algorithmic methods. This paper describes a technique using a neural network and image processing technologies which increases the reliability of target recognition systems. Unlike algorithmic methods, the neural network can be trained to identify the characteristic patterns that distinguish targets from other objects of similar size and appearance and can adapt to changes in lighting and environmental conditions.

  15. Tradeoffs among watershed model calibration targets for parameter estimation

    EPA Science Inventory

    Hydrologic models are commonly calibrated by optimizing a single objective function target to compare simulated and observed flows, although individual targets are influenced by specific flow modes. Nash-Sutcliffe efficiency (NSE) emphasizes flood peaks in evaluating simulation f...

  16. Improved quasi parton distribution through Wilson line renormalization

    NASA Astrophysics Data System (ADS)

    Chen, Jiunn-Wei; Ji, Xiangdong; Zhang, Jian-Hui

    2017-02-01

    Recent developments showed that hadron light-cone parton distributions could be directly extracted from spacelike correlators, known as quasi parton distributions, in the large hadron momentum limit. Unlike the normal light-cone parton distribution, a quasi parton distribution contains ultraviolet (UV) power divergence associated with the Wilson line self energy. We show that to all orders in the coupling expansion, the power divergence can be removed by a "mass" counterterm in the auxiliary z-field formalism, in the same way as the renormalization of power divergence for an open Wilson line. After adding this counterterm, the quasi quark distribution is improved such that it contains at most logarithmic divergences. Based on a simple version of discretized gauge action, we present the one-loop matching kernel between the improved non-singlet quasi quark distribution with a lattice regulator and the corresponding quark distribution in dimensional regularization.

  17. The ABM parton distributions tuned to LHC data

    NASA Astrophysics Data System (ADS)

    Alekhin, S.; Blümlein, J.; Moch, S.

    2014-03-01

    We present a global fit of parton distributions at next-to-next-to-leading order (NNLO) in QCD. The fit is based on the world data for deep-inelastic scattering, fixed-target data for the Drell-Yan process and includes, for the first time, data from the Large Hadron Collider (LHC) for the Drell-Yan process and the hadroproduction of top-quark pairs. The analysis applies the fixed-flavor number scheme for nf=3, 4, 5, uses the MS¯ scheme for the strong coupling αs and the heavy-quark masses and keeps full account of the correlations among all nonperturbative parameters. At NNLO this returns the values of αs(MZ)=0.1132±0.0011 and mt(pole)=171.2±2.4 GeV for the top-quark pole mass. The fit results are used to compute benchmark cross sections for the Higgs production at the LHC to NNLO accuracy. We compare our results to those obtained by other groups and show that differences can be linked to different theoretical descriptions of the underlying physical processes.

  18. Multiple parton interaction studies at DØ

    DOE PAGES

    Lincoln, D.

    2016-04-01

    Here, we present the results of studies of multiparton interactions done by the DØ collaboration using the Fermilab Tevatron at a center of mass energy of 1.96 TeV. We also present three analyses, involving three distinct final signatures: (a) a photon with at least 3 jets ( γ + 3jets), (b) a photon with a bottom or charm quark tagged jet and at least 2 other jets ( γ + b/c + 2jets), and (c) two J/ ψ mesons. The fraction of photon + jet events initiated by double parton scattering is about 20%, while the fraction for events inmore » which two J/ ψ mesons were produced is 30 ± 10. While the two measurements are statistically compatible, the difference might indicate differences in the quark and gluon distribution within a nucleon. Finally, this speculation originates from the fact that photon + jet events are created by collisions with quarks in the initial states, while J/ ψ events are produced preferentially by a gluonic initial state.« less

  19. Multiple parton interaction studies at DØ

    SciTech Connect

    Lincoln, D.

    2016-04-01

    Here, we present the results of studies of multiparton interactions done by the DØ collaboration using the Fermilab Tevatron at a center of mass energy of 1.96 TeV. We also present three analyses, involving three distinct final signatures: (a) a photon with at least 3 jets ( γ + 3jets), (b) a photon with a bottom or charm quark tagged jet and at least 2 other jets ( γ + b/c + 2jets), and (c) two J/ ψ mesons. The fraction of photon + jet events initiated by double parton scattering is about 20%, while the fraction for events in which two J/ ψ mesons were produced is 30 ± 10. While the two measurements are statistically compatible, the difference might indicate differences in the quark and gluon distribution within a nucleon. Finally, this speculation originates from the fact that photon + jet events are created by collisions with quarks in the initial states, while J/ ψ events are produced preferentially by a gluonic initial state.

  20. Modeling projectile impact onto prestressed ceramic targets

    NASA Astrophysics Data System (ADS)

    Holmquist, T. J.; Johnson, G. R.

    2003-09-01

    This work presents computed results for the responses of ceramic targets, with and without prestress, subjected to projectile impact. Also presented is a computational technique to include prestress. Ceramic materials have been considered for armor applications for many years because of their high strength and low density. Many researchers have demonstrated that providing confinement enhances the ballistic performance of ceramic targets. More recently, prestressing the ceramic is being considered as an additional enhancement technique. This work investigates the effect of prestressing the ceramic for both thin and thick target configurations subjected to projectile impact. In all cases the targets with ceramic prestress provided enhanced ballistic performance. The computed results indicate that prestressed ceramic reduces and/or delays failure, resulting in improved ceramic performance and ballistic efficiency.

  1. Echo signal modeling of imaging LADAR target simulator

    NASA Astrophysics Data System (ADS)

    Xu, Rui; Shi, Rui; Wang, Xin; Li, Zhuo

    2014-11-01

    LADAR guidance technology is one of the most promising precision guidance technologies. In the aim of simulating the return waveform of the target, a 3D geometrical model of a target is built and mathematical model of target echo signal for imaging LADAR target simulator is established by using the coordinate transformation, radar equation and ranging equation. First, the 3D geometrical data of the object model is obtained by 3D geometrical modeling. Then, target coordinate system and viewpoint coordinate system are created respectively. 3D geometrical model is built in the target coordinate system. The 3D geometrical model is transformed to the viewpoint coordinate system based on the derived relationship between the two coordinate systems. Furthermore, the range information of the target could be obtained under viewpoint coordinate system. Thus, the data of the target echo signal can be obtained by using radar equation and ranging equation. Finally, the echo signal can be exported through corresponding data interface. In order to validate the method proposed in this paper, the echo signal generated by a typical target is computed and compared with the theory solutions. The signals can be applied to drive target simulator to generate a physical target LADAR image.

  2. MMW turntable data collection, data analysis, and target model development

    NASA Astrophysics Data System (ADS)

    Saylor, Annie V.; Barr, Douglas P.; Mobley, Scott B.; Leonard, Wayne

    2000-07-01

    Turntable data collection on ground targets using an instrumentation W-band monopulse radar is reported. The data collection site, instrumentation, and test methodology are described. Preliminary analysis results showing target RCS comparisons are reported. The turntable measurements are used to generate point scatterer target models for all-digital and real-time hardware-in-the-loop (HWIL) simulations. Model development techniques are described. The models are validated against measured data utilizing generic high range resolution acquisition and tracking algorithms.

  3. CT10 NLO and NNLO Parton Distribution Functions from the Coordinated Theoretical-Experimental Project on QCD

    DOE Data Explorer

    Huston, Joey [Co-Spokesperson; Ownes, Joseph [Co-Spokesperson

    The Coordinated Theoretical-Experimental Project on QCD is a multi-institutional collaboration devoted to a broad program of research projects and cooperative enterprises in high-energy physics centered on Quantum Chromodynamics (QCD) and its implications in all areas of the Standard Model and beyond. The Collaboration consists of theorists and experimentalists at 18 universities and 5 national laboratories. More than 65 sets of Parton Distribution Functions are available for public access. Links to many online software tools, information about Parton Distribution Functions, papers, and other resources are also available.

  4. Transorbital target localization in the porcine model

    NASA Astrophysics Data System (ADS)

    DeLisi, Michael P.; Mawn, Louise A.; Galloway, Robert L.

    2013-03-01

    Current pharmacological therapies for the treatment of chronic optic neuropathies such as glaucoma are often inadequate due to their inability to directly affect the optic nerve and prevent neuron death. While drugs that target the neurons have been developed, existing methods of administration are not capable of delivering an effective dose of medication along the entire length of the nerve. We have developed an image-guided system that utilizes a magnetically tracked flexible endoscope to navigate to the back of the eye and administer therapy directly to the optic nerve. We demonstrate the capabilities of this system with a series of targeted surgical interventions in the orbits of live pigs. Target objects consisted of NMR microspherical bulbs with a volume of 18 μL filled with either water or diluted gadolinium-based contrast, and prepared with either the presence or absence of a visible coloring agent. A total of 6 pigs were placed under general anesthesia and two microspheres of differing color and contrast content were blindly implanted in the fat tissue of each orbit. The pigs were scanned with T1-weighted MRI, image volumes were registered, and the microsphere containing gadolinium contrast was designated as the target. The surgeon was required to navigate the flexible endoscope to the target and identify it by color. For the last three pigs, a 2D/3D registration was performed such that the target's coordinates in the image volume was noted and its location on the video stream was displayed with a crosshair to aid in navigation. The surgeon was able to correctly identify the target by color, with an average intervention time of 20 minutes for the first three pigs and 3 minutes for the last three.

  5. Dual parametrization of generalized parton distributions in two equivalent representations

    NASA Astrophysics Data System (ADS)

    Müller, D.; Polyakov, M. V.; Semenov-Tian-Shansky, K. M.

    2015-03-01

    The dual parametrization and the Mellin-Barnes integral approach represent two frameworks for handling the double partial wave expansion of generalized parton distributions (GPDs) in the conformal partial waves and in the t-channel SO(3) partial waves. Within the dual parametrization framework, GPDs are represented as integral convolutions of forward-like functions whose Mellin moments generate the conformal moments of GPDs. The Mellin-Barnes integral approach is based on the analytic continuation of the GPD conformal moments to the complex values of the conformal spin. GPDs are then represented as the Mellin-Barnes-type integrals in the complex conformal spin plane. In this paper we explicitly show the equivalence of these two independently developed GPD representations. Furthermore, we clarify the notions of the J = 0 fixed pole and the D-form factor. We also provide some insight into GPD modeling and map the phenomenologically successful Kumerički-Müller GPD model to the dual parametrization framework by presenting the set of the corresponding forward-like functions. We also build up the reparametrization procedure allowing to recast the double distribution representation of GPDs in the Mellin-Barnes integral framework and present the explicit formula for mapping double distributions into the space of double partial wave amplitudes with complex conformal spin.

  6. TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models

    NASA Astrophysics Data System (ADS)

    Yao, Zhi-Jiang; Dong, Jie; Che, Yu-Jing; Zhu, Min-Feng; Wen, Ming; Wang, Ning-Ning; Wang, Shan; Lu, Ai-Ping; Cao, Dong-Sheng

    2016-05-01

    Drug-target interactions (DTIs) are central to current drug discovery processes and public health fields. Analyzing the DTI profiling of the drugs helps to infer drug indications, adverse drug reactions, drug-drug interactions, and drug mode of actions. Therefore, it is of high importance to reliably and fast predict DTI profiling of the drugs on a genome-scale level. Here, we develop the TargetNet server, which can make real-time DTI predictions based only on molecular structures, following the spirit of multi-target SAR methodology. Naïve Bayes models together with various molecular fingerprints were employed to construct prediction models. Ensemble learning from these fingerprints was also provided to improve the prediction ability. When the user submits a molecule, the server will predict the activity of the user's molecule across 623 human proteins by the established high quality SAR model, thus generating a DTI profiling that can be used as a feature vector of chemicals for wide applications. The 623 SAR models related to 623 human proteins were strictly evaluated and validated by several model validation strategies, resulting in the AUC scores of 75-100 %. We applied the generated DTI profiling to successfully predict potential targets, toxicity classification, drug-drug interactions, and drug mode of action, which sufficiently demonstrated the wide application value of the potential DTI profiling. The TargetNet webserver is designed based on the Django framework in Python, and is freely accessible at http://targetnet.scbdd.com.

  7. Parallelizing the track-target model for the MIMD machine

    SciTech Connect

    Zhong Xiong, W.; Swietlik, C.

    1992-09-01

    Military Tracking-Target systems are important analysis tools for modelling the major functions of a strategic defense system operating against a ballistic missile threat during a simulated end-to-end scenario. As demands grow for modelling more trajectories with increasing numbers of missile types, so have demands for more processing power. Argonne National Laboratory has developed the parallel version of this Tracking-Target model. The parallel version has exhibited speedups of up to a factor of 6.3 resulting from a shared memory multiprocessor machine. This paper documents a project to implement the Tracking-Target model on a parallel processing environment.

  8. Reconstruction of Monte Carlo replicas from Hessian parton distributions

    NASA Astrophysics Data System (ADS)

    Hou, Tie-Jiun; Gao, Jun; Huston, Joey; Nadolsky, Pavel; Schmidt, Carl; Stump, Daniel; Wang, Bo-Ting; Xie, Ke Ping; Dulat, Sayipjamal; Pumplin, Jon; Yuan, C. P.

    2017-03-01

    We explore connections between two common methods for quantifying the uncertainty in parton distribution functions (PDFs), based on the Hessian error matrix and Monte-Carlo sampling. CT14 parton distributions in the Hessian representation are converted into Monte-Carlo replicas by a numerical method that reproduces important properties of CT14 Hessian PDFs: the asymmetry of CT14 uncertainties and positivity of individual parton distributions. The ensembles of CT14 Monte-Carlo replicas constructed this way at NNLO and NLO are suitable for various collider applications, such as cross section reweighting. Master formulas for computation of asymmetric standard deviations in the Monte-Carlo representation are derived. A correction is proposed to address a bias in asymmetric uncertainties introduced by the Taylor series approximation. A numerical program is made available for conversion of Hessian PDFs into Monte-Carlo replicas according to normal, log-normal, and Watt-Thorne sampling procedures.

  9. Transverse momentum dependent (TMD) parton distribution functions: Status and prospects*

    DOE PAGES

    Angeles-Martinez, R.; Bacchetta, A.; Balitsky, Ian I.; ...

    2015-01-01

    In this study, we review transverse momentum dependent (TMD) parton distribution functions, their application to topical issues in high-energy physics phenomenology, and their theoretical connections with QCD resummation, evolution and factorization theorems. We illustrate the use of TMDs via examples of multi-scale problems in hadronic collisions. These include transverse momentum qT spectra of Higgs and vector bosons for low qT, and azimuthal correlations in the production of multiple jets associated with heavy bosons at large jet masses. We discuss computational tools for TMDs, and present the application of a new tool, TMDLIB, to parton density fits and parameterizations.

  10. Delineating the polarized and unpolarized partonic structure of the nucleon

    SciTech Connect

    Jimenez-Delgado, Pedro

    2015-03-01

    Reports on our latest extractions of parton distribution functions of the nucleon are given. First an overview of the recent JR14 upgrade of our unpolarized PDFs, including NNLO determinations of the strong coupling constant and a discussion of the role of the input scale in parton distribution analysis. In the second part of the talk recent results on the determination of spin-dependent PDFs from the JAM collaboration are reported, including a careful treatment of hadronic and nuclear corrections, as well as reports on the impact of present and future data in our understanding of the spin of the nucleon.

  11. Delineating the polarized and unpolarized partonic structure of the nucleon

    SciTech Connect

    Jimenez-Delgado, Pedro

    2015-03-01

    Our latest results on the extraction of parton distribution functions of the nucleon are reported. First an overview of the recent JR14 upgrade of our unpolarized PDFs, including NNLO determinations of the strong coupling constant and a discussion of the role of the input scale in parton distribution analysis. In the second part of the talk recent results on the determination of spin-dependent PDFs from the JAM collaboration are given, including a careful treatment of hadronic and nuclear corrections, as well as results on the impact of present and future data in our understanding of the spin of the nucleon.

  12. Implications of current constraints on parton charge symmetry

    SciTech Connect

    J. T. Londergan; A. W. Thomas

    2005-11-01

    For the first time, charge symmetry breaking terms in parton distribution functions have been included in a global fit to high energy data. We review the results obtained for both valence and sea quark charge symmetry violation and compare these results with the most stringent experimental upper limits on charge symmetry violation for parton distribution functions, as well as with theoretical estimates of charge symmetry violation. The limits allowed in the global fit would tolerate a rather large violation of charge symmetry. We discuss the implications of this for various observables, including extraction of the Weinberg angle in neutrino DIS and the Gottfried and Adler sum rules.

  13. The role of the input scale in parton distribution analyses

    SciTech Connect

    Pedro Jimenez-Delgado

    2012-08-01

    A first systematic study of the effects of the choice of the input scale in global determinations of parton distributions and QCD parameters is presented. It is shown that, although in principle the results should not depend on these choices, in practice a relevant dependence develops as a consequence of what is called procedural bias. This uncertainty should be considered in addition to other theoretical and experimental errors, and a practical procedure for its estimation is proposed. Possible sources of mistakes in the determination of QCD parameter from parton distribution analysis are pointed out.

  14. Parton distribution functions in Monte Carlo factorisation scheme

    NASA Astrophysics Data System (ADS)

    Jadach, S.; Płaczek, W.; Sapeta, S.; Siódmok, A.; Skrzypek, M.

    2016-12-01

    A next step in development of the KrkNLO method of including complete NLO QCD corrections to hard processes in a LO parton-shower Monte Carlo is presented. It consists of a generalisation of the method, previously used for the Drell-Yan process, to Higgs-boson production. This extension is accompanied with the complete description of parton distribution functions in a dedicated, Monte Carlo factorisation scheme, applicable to any process of production of one or more colour-neutral particles in hadron-hadron collisions.

  15. Interference effect in elastic parton energy loss in a finitemedium

    SciTech Connect

    Wang, Xin-Nian

    2005-04-18

    Similar to the radiative parton energy loss due to gluonbremsstrahlung, elastic energy loss of a parton undergoing multiplescattering in a finite medium is demonstrated to be sensitive tointerference effect. The interference between amplitudes of elasticscattering via a gluon exchange and that of gluon radiation reduces theeffective elastic energy loss in a finite medium and gives rise to anon-trivial length dependence. The reduction is most significant for apropagation length L<4/\\pi T in a medium with a temperature T. Thoughthe finite size effect is not significant for the average partonpropagation in the most central heavy-ion collisions, it will affect thecentrality dependence of its effect on jet quenching.

  16. Double Parton Interactions in pp and pA Collisions

    NASA Astrophysics Data System (ADS)

    Treleani, Daniele; Calucci, Giorgio; Salvini, Simona

    2016-11-01

    As a consequence of the increasingly large flux of partons at small x, Double Parton Interactions (DPI) play an increasingly important role at high energies. A detail understanding of DPI dynamics is therefore mandatory, for a reliable subtraction of the background in the search of new physics. On the other hand, DPI are an interesting topic of research by themselves, as DPI probe the hadron structure in a rather different way, as compared with the large pt processes usually considered. In this note we will make a short illustration of some of the main features characterizing DPI in pp and in pA collisions.

  17. Monte Carlo modeling of spallation targets containing uranium and americium

    NASA Astrophysics Data System (ADS)

    Malyshkin, Yury; Pshenichnov, Igor; Mishustin, Igor; Greiner, Walter

    2014-09-01

    Neutron production and transport in spallation targets made of uranium and americium are studied with a Geant4-based code MCADS (Monte Carlo model for Accelerator Driven Systems). A good agreement of MCADS results with experimental data on neutron- and proton-induced reactions on 241Am and 243Am nuclei allows to use this model for simulations with extended Am targets. It was demonstrated that MCADS model can be used for calculating the values of critical mass for 233,235U, 237Np, 239Pu and 241Am. Several geometry options and material compositions (U, U + Am, Am, Am2O3) are considered for spallation targets to be used in Accelerator Driven Systems. All considered options operate as deep subcritical targets having neutron multiplication factor of k∼0.5. It is found that more than 4 kg of Am can be burned in one spallation target during the first year of operation.

  18. Analytical characterization of a Bruderhedral calibration target model

    NASA Astrophysics Data System (ADS)

    Cremona-Simmons, Peter M.

    1996-06-01

    The Army Research Laboratory (ARL) has constructed a variation of the bruderhedral calibration and radar cross section (RCS) target model and measured its radar characteristics in the field. A computer version of the same model was generated, and later characterized in both elevation and azimuth for validation. Our goal is to develop a millimeter-wave (MMW) signature generation tool for guidance integrated fuzing (GIF) systems and applications. Before realizing this goal, one must develop a test-bed of tools and approaches upon which to build. ARL has identified approaches to developing generic analytical target-signature models based on some existing electromagnetic scattering codes. A high-frequency RCS and signature prediction software model was selected to perform the radar analysis and provide a mechanism, a synthetic aperture radar (SAR) model, for recognizing prominent scatterers off high-fidelity target models. This method will assist us in creating suitable far- to near-field 3-D transitional models at MMW frequencies. Two target model descriptions were used in the signature prediction model: a flat facet format and a curved surface format. This paper introduces these software models, and some optics and SAR considerations relating to the test wavelength and the size of the target. Also, the simulated azimuthal and elevation response patterns, along with some results from the SAR model, are presented.

  19. The Sender-Receiver Model and the Targeting Process.

    ERIC Educational Resources Information Center

    Larson, Mark A.

    The goal of this paper is to describe how one classroom teacher uses the Sender-Receiver Communications Model to illustrate for students in a lively and memorable way the process of "targeting your audience" with medium and message. Students are used as examples of Receivers, or target audience, illustrating the potential range of…

  20. Modeling Natural Killer Cell Targeted Immunotherapies

    PubMed Central

    Lopez-Lastra, Silvia; Di Santo, James P.

    2017-01-01

    Animal models have extensively contributed to our understanding of human immunobiology and to uncover the underlying pathological mechanisms occurring in the development of diseases. However, mouse models do not reproduce the genetic and molecular complexity inherent in human disease conditions. Human immune system (HIS) mouse models that are susceptible to human pathogens and can recapitulate human hematopoiesis and tumor immunobiology provide one means to bridge the interspecies gap. Natural killer cells are the founding member of the innate lymphoid cell family. They exert a rapid and strong immune response against tumor and pathogen-infected cells. Their antitumor features have long been exploited for therapeutic purposes in the context of cancer. In this review, we detail the development of highly immunodeficient mouse strains and the models currently used in cancer research. We summarize the latest improvements in adoptive natural killer (NK) cell therapies and the development of novel NK cell sources. Finally, we discuss the advantages of HIS mice to study the interactions between human NK cells and human cancers and to develop new therapeutic strategies.

  1. Physicochemical model for reactive sputtering of hot target

    NASA Astrophysics Data System (ADS)

    Shapovalov, Viktor I.; Karzin, Vitaliy V.; Bondarenko, Anastasia S.

    2017-02-01

    A physicochemical model for reactive magnetron sputtering of a metal target is described in this paper. The target temperature in the model is defined as a function of the ion current density. Synthesis of the coating occurs due to the surface chemical reaction. The law of mass action, the Langmuir isotherm and the Arrhenius equation for non-isothermal conditions were used for mathematical description of the reaction. The model takes into consideration thermal electron emission and evaporation of the target surface. The system of eight algebraic equations, describing the model, was solved for the tantalum target sputtered in the oxygen environment. It was established that the hysteresis effect disappears with the increase of the ion current density.

  2. Target signature modeling and bistatic scattering measurement studies

    NASA Technical Reports Server (NTRS)

    Burnside, W. D.; Lee, T. H.; Rojas, R.; Marhefka, R. J.; Bensman, D.

    1989-01-01

    Four areas of study are summarized: bistatic scattering measurements studies for a compact range; target signature modeling for test and evaluation hardware in the loop situation; aircraft code modification study; and SATCOM antenna studies on aircraft.

  3. Georeferenced model simulations efficiently support targeted monitoring

    NASA Astrophysics Data System (ADS)

    Berlekamp, Jürgen; Klasmeier, Jörg

    2010-05-01

    The European Water Framework Directive (WFD) demands the good ecological and chemical status of surface waters. To meet the definition of good chemical status of the WFD surface water concentrations of priority pollutants must not exceed established environmental quality standards (EQS). Surveillance of the concentrations of numerous chemical pollutants in whole river basins by monitoring is laborious and time-consuming. Moreover, measured data do often not allow for immediate source apportionment which is a prerequisite for defining promising reduction strategies to be implemented within the programme of measures. In this context, spatially explicit model approaches are highly advantageous because they provide a direct link between local point emissions (e.g. treated wastewater) or diffuse non-point emissions (e.g. agricultural runoff) and resulting surface water concentrations. Scenario analyses with such models allow for a priori investigation of potential positive effects of reduction measures such as optimization of wastewater treatment. The geo-referenced model GREAT-ER (Geography-referenced Regional Exposure Assessment Tool for European Rivers) has been designed to calculate spatially resolved averaged concentrations for different flow conditions (e.g. mean or low flow) based on emission estimations for local point source emissions such as treated effluents from wastewater treatment plants. The methodology was applied to selected pharmaceuticals (diclofenac, sotalol, metoprolol, carbamazepin) in the Main river basin in Germany (approx. 27,290 km²). Average concentrations of the compounds were calculated for each river reach in the whole catchment. Simulation results were evaluated by comparison with available data from orienting monitoring and used to develop an optimal monitoring strategy for the assessment of water quality regarding micropollutants at the catchment scale.

  4. In-Medium Parton Branching Beyond Eikonal Approximation

    NASA Astrophysics Data System (ADS)

    Apolinário, Liliana

    2017-03-01

    The description of the in-medium modifications of partonic showers has been at the forefront of current theoretical and experimental efforts in heavy-ion collisions. It provides a unique laboratory to extend our knowledge frontier of the theory of the strong interactions, and to assess the properties of the hot and dense medium (QGP) that is produced in ultra-relativistic heavy-ion collisions at RHIC and the LHC. The theory of jet quenching, a commonly used alias for the modifications of the parton branching resulting from the interactions with the QGP, has been significantly developed over the last years. Within a weak coupling approach, several elementary processes that build up the parton shower evolution, such as single gluon emissions, interference effects between successive emissions and corrections to radiative energy loss of massive quarks, have been addressed both at eikonal accuracy and beyond by taking into account the Brownian motion that high-energy particles experience when traversing a hot and dense medium. In this work, by using the setup of single gluon emission from a color correlated quark-antiquark pair in a singlet state (qbar{q} antenna), we calculate the in-medium gluon radiation spectrum beyond the eikonal approximation. The results show that we are able to factorize broadening effects from the modifications of the radiation process itself. This constitutes the final proof that a probabilistic picture of the parton shower evolution holds even in the presence of a QGP.

  5. Recent progress in the statistical approach of parton distributions

    SciTech Connect

    Soffer, Jacques

    2011-07-15

    We recall the physical features of the parton distributions in the quantum statistical approach of the nucleon. Some predictions from a next-to-leading order QCD analysis are compared to recent experimental results. We also consider their extension to include their transverse momentum dependence.

  6. Unbiased determination of polarized parton distributions and their uncertainties

    NASA Astrophysics Data System (ADS)

    Ball, Richard D.; Forte, Stefano; Guffanti, Alberto; Nocera, Emanuele R.; Ridolfi, Giovanni; Rojo, Juan

    2013-09-01

    We present a determination of a set of polarized parton distributions (PDFs) of the nucleon, at next-to-leading order, from a global set of longitudinally polarized deep-inelastic scattering data: NNPDFpol1.0. The determination is based on the NNPDF methodology: a Monte Carlo approach, with neural networks used as unbiased interpolants, previously applied to the determination of unpolarized parton distributions, and designed to provide a faithful and statistically sound representation of PDF uncertainties. We present our dataset, its statistical features, and its Monte Carlo representation. We summarize the technique used to solve the polarized evolution equations and its benchmarking, and the method used to compute physical observables. We review the NNPDF methodology for parametrization and fitting of neural networks, the algorithm used to determine the optimal fit, and its adaptation to the polarized case. We finally present our set of polarized parton distributions. We discuss its statistical properties, test for its stability upon various modifications of the fitting procedure, and compare it to other recent polarized parton sets, and in particular obtain predictions for polarized first moments of PDFs based on it. We find that the uncertainties on the gluon, and to a lesser extent the strange PDF, were substantially underestimated in previous determinations.

  7. Zebrafish: predictive model for targeted cancer therapeutics from nature.

    PubMed

    Zulkhernain, Nursafwana Syazwani; Teo, Soo Hwang; Patel, Vyomesh; Tan, Pei Jean

    2014-01-01

    Targeted therapy, the treatment of cancer based on an underlying genetic alteration, is rapidly gaining favor as the preferred therapeutic approach. To date, although natural products represent a rich resource of bio-diverse drug candidates, only a few have been identified to be effective as targeted cancer therapies largely due to the incompatibilities to current high-throughput screening methods. In this article, we review the utility of a zebrafish developmental screen for bioactive natural product-based compounds that target signaling pathways that are intimately shared with those in humans. Any bioactive compound perturbing signaling pathways identified from phenotypic developmental defects in zebrafish embryos provide an opportunity for developing targeted therapies for human cancers. This model provides a promising tool in the search for targeted cancer therapeutics from natural products.

  8. Higgs characterisation via vector-boson fusion and associated production: NLO and parton-shower effects.

    PubMed

    Maltoni, Fabio; Mawatari, Kentarou; Zaro, Marco

    Vector-boson fusion and associated production at the LHC can provide key information on the strength and structure of the Higgs couplings to the Standard Model particles. Using an effective field theory approach, we study the effects of next-to-leading order (NLO) QCD corrections matched to a parton shower on selected observables for various spin-0 hypotheses. We find that inclusion of NLO corrections is needed to reduce the theoretical uncertainties on the total rates as well as to reliably predict the shapes of the distributions. Our results are obtained in a fully automatic way via FeynRules and MadGraph5_aMC@NLO.

  9. Matching next-to-leading order predictions to parton showers in supersymmetric QCD

    SciTech Connect

    Degrande, Céline; Fuks, Benjamin; Hirschi, Valentin; Proudom, Josselin; Shao, Hua-Sheng

    2016-02-03

    We present a fully automated framework based on the FeynRules and MadGraph5_aMC@NLO programs that allows for accurate simulations of supersymmetric QCD processes at the LHC. Starting directly from a model Lagrangian that features squark and gluino interactions, event generation is achieved at the next-to-leading order in QCD, matching short-distance events to parton showers and including the subsequent decay of the produced supersymmetric particles. As an application, we study the impact of higher-order corrections in gluino pair-production in a simplified benchmark scenario inspired by current gluino LHC searches.

  10. Target model and simulation for laser imaging fuze

    NASA Astrophysics Data System (ADS)

    Li, Weiheng; Song, Chengtian

    2013-09-01

    Image detection is an important direction of fuze development nowadays, and laser imaging fuze is one of the main technologies. This paper carries out the research in simulation technology of the process with detection, scan and imaging, which is used in laser imaging fuze for tank target, and get the simulation images information of different intersection conditions, including tank spot information,distance information and power information. The target coordinate system is established with the movement characteristics,physical characteristics and existing coordinate system of tank target. And through transferring missile coordinates to the target coordinate system as well as the relative movement between the different time intervals, the model of missile-target in time and space is build up. The model is build up according to the tank target and diffusion properties of different background, including desert, soil, vegetation, and buildings. The relations of scattering power and bidirectional reflectance distribution function deduced the laser echo power calculation formula, which can calculate the echoes incidence to each surface of the laser.The design of laser imaging fuze simulation system is complicated ,which contains the technology of the process with detection, scan and imaging used in laser imaging fuze for tank target. The simulation system products the tank spot picture, the distance gradation picture, and the power gradation picture. The latter two contains two-dimensional information, the scanning distance as well as the value of echo power to meet the expected design effects.

  11. Rapid SAR target modeling through genetic inheritance mechanism

    NASA Astrophysics Data System (ADS)

    Bala, Jerzy; Pachowicz, Peter W.; Vafaie, Halleh

    1997-07-01

    The paper presents a methodology and GETP experimental system for rapid SAR target signature generation from limited initial sensory data. The methodology exploits and integrates the following four processes: (1) analysis of initial SAR image signatures and their transformation into higher-level blob representation, (2) blob modeling, (3) genetic inheritance modeling to generate new instances of a target model in blob representation, and (4) synthesis of new SAR signatures from genetically evolved blob data. The GETP system takes several SAR signatures of the target and transforms each signature into more general scattered blob graphs, where each blob represents local energy cluster. A single graph node is describe by blob relative position, confidence, and iconic data. Graph data is forwarded to the genetic modeling process while blob image is stored in a catalog. Genetic inheritance is applied to the initial population of graph data. New graph models of the target are generated and evaluated. Selected graph variations are forwarded to the synthesis process. The synthesis process restores target signature from a given graph and a catalog of blobs. The background is synthesized to complement the signature. Initial experimental results are illustrated with 64 X 32 image sections of a tank.

  12. Performance of binoculars: Berek's model of target detection.

    PubMed

    Merlitz, Holger

    2015-01-01

    A model of target detection thresholds, first presented by Max Berek of Leitz, is fitted into a simple set of closed equations. These are combined with a recently published universal formula for the human eye's pupil size to yield a versatile formalism that is capable of predicting binocular performance gains. The model encompasses target size, contrast, environmental luminance, binocular's objective diameter, magnification, angle of view, transmission, stray light, and the observer's age. We analyze performance parameters of various common binocular models and compare the results with popular approximations to binocular performance, like the well-known twilight index. The formalisms presented here are of interest in military target detection as well as in civil applications such as hunting, surveillance, object security, law enforcement, and astronomy.

  13. Theoretical model of HZE particle fragmentation by hydrogen targets

    NASA Technical Reports Server (NTRS)

    Townsend, L.W.; Cucinotta, F. A; Bagga, R.; Tripathi, R. K.

    1996-01-01

    The fragmenting of high energy, heavy ions (HZE particles) by hydrogen targets is an important, physical process in several areas of space radiation research. In this work quantum mechanical optical model methods for estimating cross sections for HZE particle fragmentation by hydrogen targets are presented. The cross sections are calculated using a modified abrasion-ablation collision formalism adapted from a nucleus-nucleus collision model. Elemental and isotopic production cross sections are estimated and compared with reported measurements for the breakup of neon, sulphur, and iron, nuclei at incident energies between 400 and 910 Mev/nucleon. Good agreement between theory and experiment is obtained.

  14. Generalized parton distributions and rapidity gap survival in exclusive diffractive pp scattering

    SciTech Connect

    Frankfurt, L.; Hyde, C. E.; Strikman, M.; Weiss, C.

    2007-03-01

    We study rapidity gap survival (RGS) in the production of high-mass systems (H=dijet, heavy quarkonium, Higgs boson) in double-gap exclusive diffractive pp scattering, pp{yields}p+(gap)+H+(gap)+p. Our approach is based on the idea that hard and soft interactions are approximately independent because they proceed over widely different time and distance scales. We implement this idea in a partonic description of proton structure, which allows for a model-independent treatment of the interplay of hard and soft interactions. The high-mass system is produced in a hard scattering process with exchange of two gluons between the protons, whose amplitude is calculable in terms of the gluon generalized parton distribution (GPD), measured in exclusive ep scattering. The hard scattering process is modified by soft spectator interactions, which we calculate neglecting correlations between hard and soft interactions (independent interaction approximation). We obtain an analytic expression for the RGS probability in terms of the phenomenological pp elastic scattering amplitude, without reference to the eikonal approximation. Contributions from inelastic intermediate states are suppressed. The onset of the black-disk limit in pp scattering at TeV energies strongly suppresses diffraction at small impact parameters and is the main factor in determining the RGS probability. Correlations between hard and soft interactions (e.g. due to scattering from the long-range pion field of the proton or due to possible short-range transverse correlations between partons) further decrease the RGS probability. We also investigate the dependence of the diffractive cross section on the transverse momenta of the final-state protons ('diffraction pattern'). By measuring this dependence one can perform detailed tests of the interplay of hard and soft interactions and even extract information about the gluon GPD in the proton. Such studies appear to be feasible with the planned forward detectors at the

  15. Global Numerical Modeling of the Muon Collider Target

    NASA Astrophysics Data System (ADS)

    Roman, Samulyak; Glimm, James

    2000-11-01

    The problem of free surface instabilities is the major concern in the study of the Muon Collider target. The target is in the form of a mercury jet interacting with high energy proton beams in the presence of a strong magnetic field. Strong pressure waves caused by the target - proton beam interaction lead to strong disturbances of the jet surface and to the jet breakup into droplets. The global numerical simulation of the Muon Collider target was done by using FronTier, a compressible fluid dynamics code. FronTier is capable to work with free surfaces and, in particular, to model the propagation of free jets. The code is based on the method of front tracking, a numerical technique for solving systems of conservation laws in which the evolution of discontinuities is determined through the solution of the associated Riemann problem. To model the behavior of the real material (mercury) under the influence of proton beams a SESAME type tabulated equation of state for mercury was created in a wide temperature - density domain which includes the fluid state of mercury, the vapor state and the state above the critical point. The numerical simulation of the target evolution driven by strong pressure waves is important for the optimal target design.

  16. Using habitat suitability models to target invasive plant species surveys.

    PubMed

    Crall, Alycia W; Jarnevich, Catherine S; Panke, Brendon; Young, Nick; Renz, Mark; Morisette, Jeffrey

    2013-01-01

    Managers need new tools for detecting the movement and spread of nonnative, invasive species. Habitat suitability models are a popular tool for mapping the potential distribution of current invaders, but the ability of these models to prioritize monitoring efforts has not been tested in the field. We tested the utility of an iterative sampling design (i.e., models based on field observations used to guide subsequent field data collection to improve the model), hypothesizing that model performance would increase when new data were gathered from targeted sampling using criteria based on the initial model results. We also tested the ability of habitat suitability models to predict the spread of invasive species, hypothesizing that models would accurately predict occurrences in the field, and that the use of targeted sampling would detect more species with less sampling effort than a nontargeted approach. We tested these hypotheses on two species at the state scale (Centaurea stoebe and Pastinaca sativa) in Wisconsin (USA), and one genus at the regional scale (Tamarix) in the western United States. These initial data were merged with environmental data at 30-m2 resolution for Wisconsin and 1-km2 resolution for the western United States to produce our first iteration models. We stratified these initial models to target field sampling and compared our models and success at detecting our species of interest to other surveys being conducted during the same field season (i.e., nontargeted sampling). Although more data did not always improve our models based on correct classification rate (CCR), sensitivity, specificity, kappa, or area under the curve (AUC), our models generated from targeted sampling data always performed better than models generated from nontargeted data. For Wisconsin species, the model described actual locations in the field fairly well (kappa = 0.51, 0.19, P < 0.01), and targeted sampling did detect more species than nontargeted sampling with less

  17. Parton Distributions in the pion from lattice QCD

    SciTech Connect

    W. Detmold; Wally Melnitchouk; Anthony Thomas

    2003-03-01

    We analyze the moments of parton distribution functions in the pion calculated in lattice QCD, paying particular attention to their chiral extrapolation. Using the lowest three non-trivial moments calculated on the lattice, we assess the accuracy with which the x-dependence of both the valence and sea quark distributions in the pion can be extracted. The resulting valence quark distributions at the physical pion mass are in fair agreement with existing Drell-Yan data, but the statistical errors are such that one cannot yet confirm (or rule out) the large-x behavior expected from hadron helicity conservation in perturbative QCD. One can expect, however, that the next generation of calculations in lattice QCD will allow one to extract parton distributions with a level of accuracy comparable with current experiments.

  18. Transverse momentum dependent (TMD) parton distribution functions: Status and prospects*

    SciTech Connect

    Angeles-Martinez, R.; Bacchetta, A.; Balitsky, Ian I.; Boer, D.; Boglione, M.; Boussarie, R.; Ceccopieri, F. A.; Cherednikov, I. O.; Connor, P.; Echevarria, M. G.; Ferrera, G.; Grados Luyando, J.; Hautmann, F.; Jung, H.; Kasemets, T.; Kutak, K.; Lansberg, J. P.; Lykasov, G.; Madrigal Martinez, J. D.; Mulders, P. J.; Nocera, E. R.; Petreska, E.; Pisano, C.; Placakyte, R.; Radescu, V.; Radici, M.; Schnell, G.; Signori, A.; Szymanowski, L.; Taheri Monfared, S.; Van der Veken, F. F.; van Haevermaet, H. J.; Van Mechelen, P.; Vladimirov, A. A.; Wallon, S.

    2015-01-01

    In this study, we review transverse momentum dependent (TMD) parton distribution functions, their application to topical issues in high-energy physics phenomenology, and their theoretical connections with QCD resummation, evolution and factorization theorems. We illustrate the use of TMDs via examples of multi-scale problems in hadronic collisions. These include transverse momentum qT spectra of Higgs and vector bosons for low qT, and azimuthal correlations in the production of multiple jets associated with heavy bosons at large jet masses. We discuss computational tools for TMDs, and present the application of a new tool, TMDLIB, to parton density fits and parameterizations.

  19. Nuclear Parton Distributions with the LHeC

    NASA Astrophysics Data System (ADS)

    Klein, Max

    2016-03-01

    Nuclear parton distributions are far from being known today because of an infant experimental base. Based on design studies of the LHeC and using new simulations, of the inclusive neutral and charged current cross section measurements and of the strange, charm and beauty densities in nuclei, it is demonstrated how that energy frontier electron-ion collider would unfold the complete set of nuclear PDFs in a hugely extended kinematic range of deep inelastic scattering, extending in Bjorken x down to values near to 10-6 in the perturbative domain. Together with a very precise and complete set of proton PDFs, the LHeC nPDFs will thoroughly change the theoretical understanding of parton dynamics and structure inside hadrons.

  20. Precision Modeling Of Targets Using The VALUE Computer Program

    NASA Astrophysics Data System (ADS)

    Hoffman, George A.; Patton, Ronald; Akerman, Alexander

    1989-08-01

    The 1976-vintage LASERX computer code has been augmented to produce realistic electro-optical images of targets. Capabilities lacking in LASERX but recently incorporated into its VALUE successor include: •Shadows cast onto the ground •Shadows cast onto parts of the target •See-through transparencies (e.g.,canopies) •Apparent images due both to atmospheric scattering and turbulence •Surfaces characterized by multiple bi-directional reflectance functions VALUE provides not only realistic target modeling by its precise and comprehensive representation of all target attributes, but additionally VALUE is very user friendly. Specifically, setup of runs is accomplished by screen prompting menus in a sequence of queries that is logical to the user. VALUE also incorporates the Optical Encounter (OPEC) software developed by Tricor Systems,Inc., Elgin, IL.

  1. Deeply Pseudoscalar Meson Electroproduction with CLAS and Generalized Parton Distributions

    SciTech Connect

    Guidal, Michel; Kubarovsky, Valery P.

    2015-06-01

    We discuss the recent data of exclusive $\\pi^0$ (and $\\pi^+$) electroproduction on the proton obtained by the CLAS collaboration at Jefferson Lab. It is observed that the cross sections, which have been decomposed in $\\sigma_T+\\epsilon\\sigma_L$, $\\sigma_{TT}$ and $\\sigma_{LT}$ structure functions, are dominated by transverse amplitude contributions. The data can be interpreted in the Generalized Parton Distribution formalism provided that one includes helicity-flip transversity GPDs.

  2. Squark production and decay matched with parton showers at NLO

    NASA Astrophysics Data System (ADS)

    Gavin, R.; Hangst, C.; Krämer, M.; Mühlleitner, M.; Pellen, M.; Popenda, E.; Spira, M.

    2015-01-01

    Extending previous work on the predictions for the production of supersymmetric (SUSY) particles at the LHC, we present the fully differential calculation of the next-to-leading order (NLO) SUSY-QCD corrections to the production of squark and squark-antisquark pairs of the first two generations. The NLO cross sections are combined with the subsequent decay of the final state (anti)squarks into the lightest neutralino and (anti)quark at NLO SUSY-QCD. No assumptions on the squark masses are made, and the various subchannels are taken into account independently. In order to obtain realistic predictions for differential distributions the fixed-order calculations have to be combined with parton showers. Making use of the Powheg method we have implemented our results in the Powheg-Box framework and interfaced the NLO calculation with the parton shower Monte Carlo programs Pythia6 and Herwig++. The code is publicly available and can be downloaded from the Powheg-Box webpage. The impact of the NLO corrections on the differential distributions is studied and parton shower effects are investigated for different benchmark scenarios.

  3. Parton distributions in the LHC era: MMHT 2014 PDFs.

    PubMed

    Harland-Lang, L A; Martin, A D; Motylinski, P; Thorne, R S

    We present LO, NLO and NNLO sets of parton distribution functions (PDFs) of the proton determined from global analyses of the available hard scattering data. These MMHT2014 PDFs supersede the 'MSTW2008' parton sets, but they are obtained within the same basic framework. We include a variety of new data sets, from the LHC, updated Tevatron data and the HERA combined H1 and ZEUS data on the total and charm structure functions. We also improve the theoretical framework of the previous analysis. These new PDFs are compared to the 'MSTW2008' parton sets. In most cases the PDFs, and the predictions, are within one standard deviation of those of MSTW2008. The major changes are the [Formula: see text] valence quark difference at small [Formula: see text] due to an improved parameterisation and, to a lesser extent, the strange quark PDF due to the effect of certain LHC data and a better treatment of the [Formula: see text] branching ratio. We compare our MMHT PDF sets with those of other collaborations; in particular with the NNPDF3.0 sets, which are contemporary with the present analysis.

  4. Parton distributions in the LHC era: MMHT 2014 PDFs

    NASA Astrophysics Data System (ADS)

    Harland-Lang, L. A.; Martin, A. D.; Motylinski, P.; Thorne, R. S.

    2015-05-01

    We present LO, NLO and NNLO sets of parton distribution functions (PDFs) of the proton determined from global analyses of the available hard scattering data. These MMHT2014 PDFs supersede the `MSTW2008' parton sets, but they are obtained within the same basic framework. We include a variety of new data sets, from the LHC, updated Tevatron data and the HERA combined H1 and ZEUS data on the total and charm structure functions. We also improve the theoretical framework of the previous analysis. These new PDFs are compared to the `MSTW2008' parton sets. In most cases the PDFs, and the predictions, are within one standard deviation of those of MSTW2008. The major changes are the valence quark difference at small due to an improved parameterisation and, to a lesser extent, the strange quark PDF due to the effect of certain LHC data and a better treatment of the branching ratio. We compare our MMHT PDF sets with those of other collaborations; in particular with the NNPDF3.0 sets, which are contemporary with the present analysis.

  5. Optical model calculations of heavy-ion target fragmentation

    NASA Technical Reports Server (NTRS)

    Townsend, L. W.; Wilson, J. W.; Cucinotta, F. A.; Norbury, J. W.

    1986-01-01

    The fragmentation of target nuclei by relativistic protons and heavy ions is described within the context of a simple abrasion-ablation-final-state interaction model. Abrasion is described by a quantum mechanical formalism utilizing an optical model potential approximation. Nuclear charge distributions of the excited prefragments are calculated by both a hypergeometric distribution and a method based upon the zero-point oscillations of the giant dipole resonance. Excitation energies are estimated from the excess surface energy resulting from the abrasion process and the additional energy deposited by frictional spectator interactions of the abraded nucleons. The ablation probabilities are obtained from the EVA-3 computer program. Isotope production cross sections for the spallation of copper targets by relativistic protons and for the fragmenting of carbon targets by relativistic carbon, neon, and iron projectiles are calculated and compared with available experimental data.

  6. Disease modeling by gene targeting using microRNAs.

    PubMed

    Lan, C-C; Leong, I U S; Lai, D; Love, D R

    2011-01-01

    Zebrafish have proved to be a popular species for the modeling of human disease. In this context, there is a need to move beyond chemical-based mutagenesis and develop tools that target genes that are orthologous to those that are implicated in human heritable diseases. Targeting can take the form of creating mutations that are nonsense or mis-sense, or to mimic haploinsufficiency through the regulated expression of RNA effector molecules. In terms of the latter, we describe here the development and investigation of microRNA (miRNA)-based directed gene silencing methods in zebrafish. Unlike small interfering RNAs (siRNAs), miRNA-based methods offer temporal and spatial regulation of gene silencing. Proof-of-concept experiments demonstrate the efficacy of the method in zebrafish embryos, which provide the foundation for developing disease models using miRNA-based gene-targeting.

  7. Coins as intermediate targets: reconstructive analysis with synthetic body models.

    PubMed

    Thali, Michael J; Kneubuehl, Beat P; Rodriguez, William R; Smirniotopoulos, James G; Richardson, A Charles; Fowler, David; Godwin, Michael; Jurrus, Aaron; Fletcher, Douglas; Mallak, Craig

    2009-06-01

    The phenomenon of intermediate targets is well known in wound ballistics. In forensic science, models are used to reconstruct injury patterns to answer questions regarding the dynamic formation of these unusual injuries. Soft-tissue substitutes or glycerin soap and ordnance gelatin have been well established. Recently, based on previous experiences with artificial bone, a skull-brain model was developed. The goal of this study was to create and analyze a model-supported reconstruction of a real forensic case with a coin as an intermediate target. It was possible not only to demonstrate the "bullet-coin interaction," but also to recreate the wound pattern found in the victim. This case demonstrates that by using ballistic models, gunshot cases can be reproduced simply and economically, without coming into conflict with ethical guidelines.

  8. Using habitat suitability models to target invasive plant species surveys

    USGS Publications Warehouse

    Crall, Alycia W.; Jarnevich, Catherine S.; Panke, Brendon; Young, Nick; Renz, Mark; Morisette, Jeffrey

    2013-01-01

    Managers need new tools for detecting the movement and spread of nonnative, invasive species. Habitat suitability models are a popular tool for mapping the potential distribution of current invaders, but the ability of these models to prioritize monitoring efforts has not been tested in the field. We tested the utility of an iterative sampling design (i.e., models based on field observations used to guide subsequent field data collection to improve the model), hypothesizing that model performance would increase when new data were gathered from targeted sampling using criteria based on the initial model results. We also tested the ability of habitat suitability models to predict the spread of invasive species, hypothesizing that models would accurately predict occurrences in the field, and that the use of targeted sampling would detect more species with less sampling effort than a nontargeted approach. We tested these hypotheses on two species at the state scale (Centaurea stoebe and Pastinaca sativa) in Wisconsin (USA), and one genus at the regional scale (Tamarix) in the western United States. These initial data were merged with environmental data at 30-m2 resolution for Wisconsin and 1-km2 resolution for the western United States to produce our first iteration models. We stratified these initial models to target field sampling and compared our models and success at detecting our species of interest to other surveys being conducted during the same field season (i.e., nontargeted sampling). Although more data did not always improve our models based on correct classification rate (CCR), sensitivity, specificity, kappa, or area under the curve (AUC), our models generated from targeted sampling data always performed better than models generated from nontargeted data. For Wisconsin species, the model described actual locations in the field fairly well (kappa = 0.51, 0.19, P 2) = 47.42, P < 0.01). From these findings, we conclude that habitat suitability models can be

  9. Killing Sections and Sigma Models with Lie Algebroid Targets

    NASA Astrophysics Data System (ADS)

    Bruce, Andrew James

    2016-08-01

    We define and examine the notion of a Killing section of a Riemannian Lie algebroid as a natural generalisation of a Killing vector field. We show that the various expression for a vector field to be Killing naturally generalise to the setting of Lie algebroids. As an application we examine the internal symmetries of a class of sigma models for which the target space is a Riemannian Lie algebroid. Critical points of these sigma models are interpreted as generalised harmonic maps.

  10. Method calibration of the model 13145 infrared target projectors

    NASA Astrophysics Data System (ADS)

    Huang, Jianxia; Gao, Yuan; Han, Ying

    2014-11-01

    The SBIR Model 13145 Infrared Target Projectors ( The following abbreviation Evaluation Unit ) used for characterizing the performances of infrared imaging system. Test items: SiTF, MTF, NETD, MRTD, MDTD, NPS. Infrared target projectors includes two area blackbodies, a 12 position target wheel, all reflective collimator. It provide high spatial frequency differential targets, Precision differential targets imaged by infrared imaging system. And by photoelectricity convert on simulate signal or digital signal. Applications software (IR Windows TM 2001) evaluate characterizing the performances of infrared imaging system. With regards to as a whole calibration, first differently calibration for distributed component , According to calibration specification for area blackbody to calibration area blackbody, by means of to amend error factor to calibration of all reflective collimator, radiance calibration of an infrared target projectors using the SR5000 spectral radiometer, and to analyze systematic error. With regards to as parameter of infrared imaging system, need to integrate evaluation method. According to regulation with -GJB2340-1995 General specification for military thermal imaging sets -testing parameters of infrared imaging system, the results compare with results from Optical Calibration Testing Laboratory . As a goal to real calibration performances of the Evaluation Unit.

  11. Nonlinear sigma models with compact hyperbolic target spaces

    SciTech Connect

    Gubser, Steven; Saleem, Zain H.; Schoenholz, Samuel S.; Stoica, Bogdan; Stokes, James

    2016-06-23

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model [1, 2]. Unlike in the O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. In conclusion, the diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.

  12. Nonlinear sigma models with compact hyperbolic target spaces

    DOE PAGES

    Gubser, Steven; Saleem, Zain H.; Schoenholz, Samuel S.; ...

    2016-06-23

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model [1, 2]. Unlike in themore » O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. In conclusion, the diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.« less

  13. Nonlinear sigma models with compact hyperbolic target spaces

    NASA Astrophysics Data System (ADS)

    Gubser, Steven; Saleem, Zain H.; Schoenholz, Samuel S.; Stoica, Bogdan; Stokes, James

    2016-06-01

    We explore the phase structure of nonlinear sigma models with target spaces corresponding to compact quotients of hyperbolic space, focusing on the case of a hyperbolic genus-2 Riemann surface. The continuum theory of these models can be approximated by a lattice spin system which we simulate using Monte Carlo methods. The target space possesses interesting geometric and topological properties which are reflected in novel features of the sigma model. In particular, we observe a topological phase transition at a critical temperature, above which vortices proliferate, reminiscent of the Kosterlitz-Thouless phase transition in the O(2) model [1, 2]. Unlike in the O(2) case, there are many different types of vortices, suggesting a possible analogy to the Hagedorn treatment of statistical mechanics of a proliferating number of hadron species. Below the critical temperature the spins cluster around six special points in the target space known as Weierstrass points. The diversity of compact hyperbolic manifolds suggests that our model is only the simplest example of a broad class of statistical mechanical models whose main features can be understood essentially in geometric terms.

  14. Modeling astatine production in liquid lead-bismuth spallation targets

    NASA Astrophysics Data System (ADS)

    David, J. C.; Boudard, A.; Cugnon, J.; Ghali, S.; Leray, S.; Mancusi, D.; Zanini, L.

    2013-03-01

    Astatine isotopes can be produced in liquid lead-bismuth eutectic targets through proton-induced double charge exchange reactions on bismuth or in secondary helium-induced interactions. Models implemented into the most common high-energy transport codes generally have difficulties to correctly estimate their production yields as was shown recently by the ISOLDE Collaboration, which measured release rates from a lead-bismuth target irradiated by 1.4 and 1 GeV protons. In this paper, we first study the capability of the new version of the Liège intranuclear cascade model, INCL4.6, coupled to the deexcitation code ABLA07 to predict the different elementary reactions involved in the production of such isotopes through a detailed comparison of the model with the available experimental data from the literature. Although a few remaining deficiencies are identified, very satisfactory results are found, thanks in particular to improvements brought recently on the treatment of low-energy helium-induced reactions. The implementation of the models into MCNPX allows identifying the respective contributions of the different possible reaction channels in the ISOLDE case. Finally, the full simulation of the ISOLDE experiment is performed, taking into account the likely rather long diffusion time from the target, and compared with the measured diffusion rates for the different astatine isotopes, at the two studied energies, 1.4 and 1 GeV. The shape of the isotopic distribution is perfectly reproduced as well as the absolute release rates, assuming in the calculation a diffusion time between 5 and 10hours. This work finally shows that our model, thanks to the attention paid to the emission of high-energy clusters and to low-energy cluster induced reactions, can be safely used within MCNPX to predict isotopes with a charge larger than that of the target by two units in spallation targets, and, probably, more generally to isotopes created in secondary reactions induced by composite

  15. Tradeoffs among watershed model calibration targets for parameter estimation

    NASA Astrophysics Data System (ADS)

    Price, Katie; Purucker, S. Thomas; Kraemer, Stephen R.; Babendreier, Justin E.

    2012-10-01

    Hydrologic models are commonly calibrated by optimizing a single objective function target to compare simulated and observed flows, although individual targets are influenced by specific flow modes. Nash-Sutcliffe efficiency (NSE) emphasizes flood peaks in evaluating simulation fit, while modified Nash-Sutcliffe efficiency (MNS) emphasizes lower flows, and the ratio of the simulated to observed standard deviations (RSD) prioritizes flow variability. We investigated tradeoffs of calibrating streamflow on three standard objective functions (NSE, MNS, and RSD), as well as a multiobjective function aggregating these three targets to simultaneously address a range of flow conditions, for calibration of the Soil and Water Assessment Tool (SWAT) daily streamflow simulations in two watersheds. A suite of objective functions was explored to select a minimally redundant set of metrics addressing a range of flow characteristics. After each pass of 2001 simulations, an iterative informal likelihood procedure was used to subset parameter ranges. The ranges from each best-fit simulation set were used for model validation. Values for optimized parameters vary among calibrations using different objective functions, which underscores the importance of linking modeling objectives to calibration target selection. The simulation set approach yielded validated models of similar quality as seen with a single best-fit parameter set, with the added benefit of uncertainty estimations. Our approach represents a novel compromise between equifinality-based approaches and Pareto optimization. Combining the simulation set approach with the multiobjective function was demonstrated to be a practicable and flexible approach for model calibration, which can be readily modified to suit modeling goals, and is not model or location specific.

  16. NUCLEAR REACTION MODELING FOR RIA ISOL TARGET DESIGN

    SciTech Connect

    S. MASHNIK; ET AL

    2001-03-01

    Los Alamos scientists are collaborating with researchers at Argonne and Oak Ridge on the development of improved nuclear reaction physics for modeling radionuclide production in ISOL targets. This is being done in the context of the MCNPX simulation code, which is a merger of MCNP and the LAHET intranuclear cascade code, and simulates both nuclear reaction cross sections and radiation transport in the target. The CINDER code is also used to calculate the time-dependent nuclear decays for estimating induced radioactivities. They give an overview of the reaction physics improvements they are addressing, including intranuclear cascade (INC) physics, where recent high-quality inverse-kinematics residue data from GSI have led to INC spallation and fission model improvements; and preequilibrium reactions important in modeling (p,xn) and (p,xnyp) cross sections for the production of nuclides far from stability.

  17. Inducible Mouse Models for Cancer Drug Target Validation

    PubMed Central

    Jeong, Joseph H.

    2016-01-01

    Genetically-engineered mouse (GEM) models have provided significant contributions to our understanding of cancer biology and developing anticancer therapeutic strategies. The development of GEM models that faithfully recapitulate histopathological and clinical features of human cancers is one of the most pressing needs to successfully conquer cancer. In particular, doxycycline-inducible transgenic mouse models allow us to regulate (induce or suppress) the expression of a specific gene of interest within a specific tissue in a temporal manner. Leveraging this mouse model system, we can determine whether the transgene expression is required for tumor maintenance, thereby validating the transgene product as a target for anticancer drug development (target validation study). In addition, there is always a risk of tumor recurrence with cancer therapy. By analyzing recurrent tumors derived from fully regressed tumors after turning off transgene expression in tumor-bearing mice, we can gain an insight into the molecular basis of how tumor cells escape from their dependence on the transgene (tumor recurrence study). Results from such studies will ultimately allow us to predict therapeutic responses in clinical settings and develop new therapeutic strategies against recurrent tumors. The aim of this review is to highlight the significance of doxycycline-inducible transgenic mouse models in studying target validation and tumor recurrence. PMID:28053958

  18. Triple Parton Scatterings in High-Energy Proton-Proton Collisions

    NASA Astrophysics Data System (ADS)

    d'Enterria, David; Snigirev, Alexander M.

    2017-03-01

    A generic expression to compute triple parton scattering cross sections in high-energy proton-proton (p p ) collisions is presented as a function of the corresponding single parton cross sections and the transverse parton profile of the proton encoded in an effective parameter σeff,TPS . The value of σeff,TPS is closely related to the similar effective cross section that characterizes double parton scatterings, and amounts to σeff,TPS=12.5 ±4.5 mb . Estimates for triple charm (c c ¯) and bottom (b b ¯) production in p p collisions at LHC and FCC energies are presented based on next-to-next-to-leading-order perturbative calculations for single c c ¯ , b b ¯ cross sections. At √{s }≈100 TeV , about 15% of the p p collisions produce three c c ¯ pairs from three different parton-parton scatterings.

  19. Multivariate screening in food adulteration: untargeted versus targeted modelling.

    PubMed

    López, M Isabel; Trullols, Esther; Callao, M Pilar; Ruisánchez, Itziar

    2014-03-15

    Two multivariate screening strategies (untargeted and targeted modelling) have been developed to compare their ability to detect food fraud. As a case study, possible adulteration of hazelnut paste is considered. Two different adulterants were studied, almond paste and chickpea flour. The models were developed from near-infrared (NIR) data coupled with soft independent modelling of class analogy (SIMCA) as a classification technique. Regarding the untargeted strategy, only unadulterated samples were modelled, obtaining 96.3% of correct classification. The prediction of adulterated samples gave errors between 5.5% and 2%. Regarding targeted modelling, two classes were modelled: Class 1 (unadulterated samples) and Class 2 (almond adulterated samples). Samples adulterated with chickpea were predicted to prove its ability to deal with non-modelled adulterants. The results show that samples adulterated with almond were mainly classified in their own class (90.9%) and samples with chickpea were classified in Class 2 (67.3%) or not in any class (30.9%), but no one only as unadulterated.

  20. HARD PARTON PHYSICS IN HIGH ENERGY NUCLEAR COLLISIONS. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP, VOLUME 17

    SciTech Connect

    CARROLL,J.

    1999-09-10

    The RIKEN-BNL center workshop on ''Hard parton physics in high energy nuclear collisions'' was held at BNL from March 1st-5th! 1999. The focus of the workshop was on hard probes of nucleus-nucleus collisions that will be measured at RHIC with the PHENIX and STAR detectors. There were about 45 speakers and over 70 registered participants at the workshop, with roughly a quarter of the speakers from overseas. About 60% of the talks were theory talks. A nice overview of theory for RHIC was provided by George Sterman. The theoretical talks were on a wide range of topics in QCD which can be classified under the following: (a) energy loss and the Landau-Pomeranchuk-Migdal effect; (b) minijet production and equilibration; (c) small x physics and initial conditions; (d) nuclear parton distributions and shadowing; (e) spin physics; (f) photon, di-lepton, and charm production; and (g) hadronization, and simulations of high pt physics in event generators. Several of the experimental talks discussed the capabilities of the PHENIX and STAR detectors at RHIC in measuring high pt particles in heavy ion collisions. In general, these talks were included in the relevant theory sessions. A session was set aside to discuss the spin program at RHIC with polarized proton beams. In addition, there were speakers from 08, HERA, the fixed target experiments at Fermilab, and the CERN fixed target Pb+Pb program, who provided additional perspective on a range of issues of relevance to RHIC; from jets at the Tevatron, to saturation of parton distributions at HERA, and recent puzzling data on direct photon production in fixed target experiments, among others.

  1. VALIDATION OF THE CORONAL THICK TARGET SOURCE MODEL

    SciTech Connect

    Fleishman, Gregory D.; Xu, Yan; Nita, Gelu N.; Gary, Dale E.

    2016-01-10

    We present detailed 3D modeling of a dense, coronal thick-target X-ray flare using the GX Simulator tool, photospheric magnetic measurements, and microwave imaging and spectroscopy data. The developed model offers a remarkable agreement between the synthesized and observed spectra and images in both X-ray and microwave domains, which validates the entire model. The flaring loop parameters are chosen to reproduce the emission measure, temperature, and the nonthermal electron distribution at low energies derived from the X-ray spectral fit, while the remaining parameters, unconstrained by the X-ray data, are selected such as to match the microwave images and total power spectra. The modeling suggests that the accelerated electrons are trapped in the coronal part of the flaring loop, but away from where the magnetic field is minimal, and, thus, demonstrates that the data are clearly inconsistent with electron magnetic trapping in the weak diffusion regime mediated by the Coulomb collisions. Thus, the modeling supports the interpretation of the coronal thick-target sources as sites of electron acceleration in flares and supplies us with a realistic 3D model with physical parameters of the acceleration region and flaring loop.

  2. Validation of the Coronal Thick Target Source Model

    NASA Astrophysics Data System (ADS)

    Fleishman, Gregory D.; Xu, Yan; Nita, Gelu N.; Gary, Dale E.

    2016-01-01

    We present detailed 3D modeling of a dense, coronal thick-target X-ray flare using the GX Simulator tool, photospheric magnetic measurements, and microwave imaging and spectroscopy data. The developed model offers a remarkable agreement between the synthesized and observed spectra and images in both X-ray and microwave domains, which validates the entire model. The flaring loop parameters are chosen to reproduce the emission measure, temperature, and the nonthermal electron distribution at low energies derived from the X-ray spectral fit, while the remaining parameters, unconstrained by the X-ray data, are selected such as to match the microwave images and total power spectra. The modeling suggests that the accelerated electrons are trapped in the coronal part of the flaring loop, but away from where the magnetic field is minimal, and, thus, demonstrates that the data are clearly inconsistent with electron magnetic trapping in the weak diffusion regime mediated by the Coulomb collisions. Thus, the modeling supports the interpretation of the coronal thick-target sources as sites of electron acceleration in flares and supplies us with a realistic 3D model with physical parameters of the acceleration region and flaring loop.

  3. Transverse Momentum-Dependent Parton Distributions From Lattice QCD

    SciTech Connect

    Michael Engelhardt, Bernhard Musch, Philipp Haegler, Andreas Schaefer

    2012-12-01

    Starting from a definition of transverse momentum-dependent parton distributions for semi-inclusive deep inelastic scattering and the Drell-Yan process, given in terms of matrix elements of a quark bilocal operator containing a staple-shaped Wilson connection, a scheme to determine such observables in lattice QCD is developed and explored. Parametrizing the aforementioned matrix elements in terms of invariant amplitudes permits a simple transformation of the problem to a Lorentz frame suited for the lattice calculation. Results for the Sivers and Boer-Mulders transverse momentum shifts are presented, focusing in particular on their dependence on the staple extent and the Collins-Soper evolution parameter.

  4. Pion and kaon valence-quark parton distribution functions

    SciTech Connect

    Nguyen, Trang; Bashir, Adnan; Roberts, Craig D.; Tandy, Peter C.

    2011-06-15

    A rainbow-ladder truncation of QCD's Dyson-Schwinger equations, constrained by existing applications to hadron physics, is employed to compute the valence-quark parton distribution functions of the pion and kaon. Comparison is made to {pi}-N Drell-Yan data for the pion's u-quark distribution and to Drell-Yan data for the ratio u{sub K}(x)/u{sub {pi}}(x): the environmental influence of this quantity is a parameter-free prediction, which agrees well with existing data. Our analysis unifies the computation of distribution functions with that of numerous other properties of pseudoscalar mesons.

  5. Pion and kaon valence-quark parton distribution functions.

    SciTech Connect

    Nguyen, T.; Bashir, A.; Roberts, C. D.; Tandy, P. C.

    2011-06-16

    A rainbow-ladder truncation of QCD's Dyson-Schwinger equations, constrained by existing applications to hadron physics, is employed to compute the valence-quark parton distribution functions of the pion and kaon. Comparison is made to {pi}-N Drell-Yan data for the pion's u-quark distribution and to Drell-Yan data for the ratio u{sub K}(x)/u{sub {pi}}(x): the environmental influence of this quantity is a parameter-free prediction, which agrees well with existing data. Our analysis unifies the computation of distribution functions with that of numerous other properties of pseudoscalar mesons.

  6. APFELgrid : A high performance tool for parton density determinations

    NASA Astrophysics Data System (ADS)

    Bertone, Valerio; Carrazza, Stefano; Hartland, Nathan P.

    2017-03-01

    We present a new software package designed to reduce the computational burden of hadron collider measurements in Parton Distribution Function (PDF) fits. The APFELgrid package converts interpolated weight tables provided by APPLgrid files into a more efficient format for PDF fitting by the combination with PDF and αs evolution factors provided by APFEL. This combination significantly reduces the number of operations required to perform the calculation of hadronic observables in PDF fits and simplifies the structure of the calculation into a readily optimised scalar product. We demonstrate that our technique can lead to a substantial speed improvement when compared to existing methods without any reduction in numerical accuracy.

  7. Model-based HSF using by target point control function

    NASA Astrophysics Data System (ADS)

    Kim, Seongjin; Do, Munhoe; An, Yongbae; Choi, Jaeseung; Yang, Hyunjo; Yim, Donggyu

    2015-03-01

    As the technology node shrinks, ArF Immersion reaches the limitation of wafer patterning, furthermore weak point during the mask processing is generated easily. In order to make strong patterning result, the design house conducts lithography rule checking (LRC). Despite LRC processing, we found the weak point at the verification stage of optical proximity correction (OPC). It is called the hot spot point (HSP). In order to fix the HSP, many studies have been performed. One of the most general hot spot fixing (HSF) methods is that the modification bias which consists of "Line-Resizing" and "Space-Resizing". In addition to the general rule biasing method, resolution enhancement techniques (RET) which includes the inverse lithography technology (ILT) and model based assist feature (MBAF) have been adapted to remove the hot spot and to maximize the process window. If HSP is found during OPC verification stage, various HSF methods can be applied. However, HSF process added on regular OPC procedure makes OPC turn-around time (TAT) increased. In this paper, we introduce a new HSF method that is able to make OPC TAT shorter than the common HSF method. The new HSF method consists of two concepts. The first one is that OPC target point is controlled to fix HSP. Here, the target point should be moved to optimum position at where the edge placement error (EPE) can be 0 at critical points. Many parameters such as a model accuracy or an OPC recipe become the cause of larger EPE. The second one includes controlling of model offset error through target point adjustment. Figure 1 shows the case EPE is not 0. It means that the simulation contour was not targeted well after OPC process. On the other hand, Figure 2 shows the target point is moved -2.5nm by using target point control function. As a result, simulation contour is matched to the original layout. This function can be powerfully adapted to OPC procedure of memory and logic devices.

  8. Modeling Human Visual Perception for Target Detection in Military Simulations

    DTIC Science & Technology

    2009-06-01

    Distractor Trials . . . . . . . . . . . . . . . . . . . 72 a. Number of Fixations Until the First Target Fixation . . 73 b. Time Until the First Target...Target and Distractor Trials . . . . . . . . . . . . . . . . . . . . . 84 h. Discussion . . . . . . . . . . . . . . . . . . . . . . . . 85 viii 4...Target and Hiding Location/ Distractor Trials . . . . . . . . . . 89 a. Number of Fixations Until Target Fixation . . . . . . . 90 b. Time Until Target

  9. Cross Sections for the Exclusive Photon Electroproduction on the Proton and Generalized Parton Distributions.

    PubMed

    Jo, H S; Girod, F X; Avakian, H; Burkert, V D; Garçon, M; Guidal, M; Kubarovsky, V; Niccolai, S; Stoler, P; Adhikari, K P; Adikaram, D; Amaryan, M J; Anderson, M D; Anefalos Pereira, S; Ball, J; Baltzell, N A; Battaglieri, M; Batourine, V; Bedlinskiy, I; Biselli, A S; Boiarinov, S; Briscoe, W J; Brooks, W K; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Colaneri, L; Cole, P L; Compton, N; Contalbrigo, M; Crede, V; D'Angelo, A; Dashyan, N; De Vita, R; De Sanctis, E; Deur, A; Djalali, C; Dupre, R; Alaoui, A El; Fassi, L El; Elouadrhiri, L; Fedotov, G; Fegan, S; Filippi, A; Fleming, J A; Garillon, B; Gevorgyan, N; Ghandilyan, Y; Gilfoyle, G P; Giovanetti, K L; Goetz, J T; Golovatch, E; Gothe, R W; Griffioen, K A; Guegan, B; Guler, N; Guo, L; Hafidi, K; Hakobyan, H; Harrison, N; Hattawy, M; Hicks, K; Hirlinger Saylor, N; Ho, D; Holtrop, M; Hughes, S M; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Jenkins, D; Joo, K; Joosten, S; Keller, D; Khachatryan, G; Khandaker, M; Kim, A; Kim, W; Klein, A; Klein, F J; Kuhn, S E; Kuleshov, S V; Lenisa, P; Livingston, K; Lu, H Y; MacGregor, I J D; McKinnon, B; Meziani, Z E; Mirazita, M; Mokeev, V; Montgomery, R A; Moutarde, H; Movsisyan, A; Munevar, E; Munoz Camacho, C; Nadel-Turonski, P; Net, L A; Niculescu, G; Osipenko, M; Ostrovidov, A I; Paolone, M; Park, K; Pasyuk, E; Phillips, J J; Pisano, S; Pogorelko, O; Price, J W; Procureur, S; Prok, Y; Puckett, A J R; Raue, B A; Ripani, M; Rizzo, A; Rosner, G; Rossi, P; Roy, P; Sabatié, F; Salgado, C; Schott, D; Schumacher, R A; Seder, E; Simonyan, A; Skorodumina, Iu; Smith, G D; Sokhan, D; Sparveris, N; Stepanyan, S; Strakovsky, I I; Strauch, S; Sytnik, V; Tian, Ye; Tkachenko, S; Ungaro, M; Voskanyan, H; Voutier, E; Walford, N K; Watts, D P; Wei, X; Weinstein, L B; Wood, M H; Zachariou, N; Zana, L; Zhang, J; Zhao, Z W; Zonta, I

    2015-11-20

    Unpolarized and beam-polarized fourfold cross sections (d^{4}σ/dQ^{2}dx_{B}dtdϕ) for the ep→e^{'}p^{'}γ reaction were measured using the CLAS detector and the 5.75-GeV polarized electron beam of the Jefferson Lab accelerator, for 110 (Q^{2},x_{B},t) bins over the widest phase space ever explored in the valence-quark region. Several models of generalized parton distributions (GPDs) describe the data well at most of our kinematics. This increases our confidence that we understand the GPD H, expected to be the dominant contributor to these observables. Through a leading-twist extraction of Compton form factors, these results support the model predictions of a larger nucleon size at lower quark-momentum fraction x_{B}.

  10. Cross Sections for the Exclusive Photon Electroproduction on the Proton and Generalized Parton Distributions

    NASA Astrophysics Data System (ADS)

    Jo, H. S.; Girod, F. X.; Avakian, H.; Burkert, V. D.; Garçon, M.; Guidal, M.; Kubarovsky, V.; Niccolai, S.; Stoler, P.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Boiarinov, S.; Briscoe, W. J.; Brooks, W. K.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dupre, R.; Alaoui, A. El; Fassi, L. El; Elouadrhiri, L.; Fedotov, G.; Fegan, S.; Filippi, A.; Fleming, J. A.; Garillon, B.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guegan, B.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Harrison, N.; Hattawy, M.; Hicks, K.; Hirlinger Saylor, N.; Ho, D.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Jenkins, D.; Joo, K.; Joosten, S.; Keller, D.; Khachatryan, G.; Khandaker, M.; Kim, A.; Kim, W.; Klein, A.; Klein, F. J.; Kuhn, S. E.; Kuleshov, S. V.; Lenisa, P.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; McKinnon, B.; Meziani, Z. E.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moutarde, H.; Movsisyan, A.; Munevar, E.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Niculescu, G.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Park, K.; Pasyuk, E.; Phillips, J. J.; Pisano, S.; Pogorelko, O.; Price, J. W.; Procureur, S.; Prok, Y.; Puckett, A. J. R.; Raue, B. A.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Seder, E.; Simonyan, A.; Skorodumina, Iu.; Smith, G. D.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.; CLAS Collaboration

    2015-11-01

    Unpolarized and beam-polarized fourfold cross sections (d4σ /d Q2d xBd t d ϕ ) for the e p →e'p'γ reaction were measured using the CLAS detector and the 5.75-GeV polarized electron beam of the Jefferson Lab accelerator, for 110 (Q2,xB,t ) bins over the widest phase space ever explored in the valence-quark region. Several models of generalized parton distributions (GPDs) describe the data well at most of our kinematics. This increases our confidence that we understand the GPD H , expected to be the dominant contributor to these observables. Through a leading-twist extraction of Compton form factors, these results support the model predictions of a larger nucleon size at lower quark-momentum fraction xB.

  11. LHAPDF6: parton density access in the LHC precision era

    NASA Astrophysics Data System (ADS)

    Buckley, Andy; Ferrando, James; Lloyd, Stephen; Nordström, Karl; Page, Ben; Rüfenacht, Martin; Schönherr, Marek; Watt, Graeme

    2015-03-01

    The Fortran LHAPDF library has been a long-term workhorse in particle physics, providing standardised access to parton density functions for experimental and phenomenological purposes alike, following on from the venerable PDFLIB package. During Run 1 of the LHC, however, several fundamental limitations in LHAPDF's design have became deeply problematic, restricting the usability of the library for important physics-study procedures and providing dangerous avenues by which to silently obtain incorrect results. In this paper we present the LHAPDF 6 library, a ground-up re-engineering of the PDFLIB/LHAPDF paradigm for PDF access which removes all limits on use of concurrent PDF sets, massively reduces static memory requirements, offers improved CPU performance, and fixes fundamental bugs in multi-set access to PDF metadata. The new design, restricted for now to interpolated PDFs, uses centralised numerical routines and a powerful cascading metadata system to decouple software releases from provision of new PDF data and allow completely general parton content. More than 200 PDF sets have been migrated from LHAPDF 5 to the new universal data format, via a stringent quality control procedure. LHAPDF 6 is supported by many Monte Carlo generators and other physics programs, in some cases via a full set of compatibility routines, and is recommended for the demanding PDF access needs of LHC Run 2 and beyond.

  12. Proton structure and parton distribution functions from HERA

    NASA Astrophysics Data System (ADS)

    Chekelian, Vladimir

    2016-11-01

    The H1 and ZEUS collaborations at the electron-proton collider HERA collected e± p scattering data corresponding to an integrated luminosity of about 1 fb-1. The data were taken at proton beam energies of 920, 820, 575 and 460 GeV and an electron beam energy of 27.5 GeV, with different electric charges and longitudinal polarisation of the electron beam. Using these data inclusive neutral and charged current deep inelastic cross sections were measured over six orders of magnitude in negative four-momentum-transfer squared, Q2, and Bjorken x. A combination of all inclusive cross sections, published by the H1 and ZEUS collaborations at HERA, was performed. Using these combined HERA data and the individual H1 and ZEUS data taken using the polarised electron beams, the proton structure functions F2, FγZ2, xFγZ3 and FL were obtained, and scaling violations, electroweak unification, and polarisation effects in the charged current process were demonstrated. The combined cross sections were used as a sole input to QCD analyses at leading, next-to-leading and next-to-next-to-leading orders, providing a new set of parton distribution functions, denoted as HERAPDF2.0. An extension of the analysis by including HERA data on charm and jet production allowed a simultaneous determination of parton distributions and the strong coupling.

  13. Non-dipolar Wilson Links for Parton Densities

    NASA Astrophysics Data System (ADS)

    Li, Hsiang-nan

    We propose a new definition of a transverse-momentum-dependent wave function with simpler soft subtraction. The unsubtracted wave function involves two pieces of non-light-like Wilson links oriented in different directions, so that the rapidity singularity appearing in usual kT factorization is regularized, and the pinched singularity from Wilson-link self-energy corrections is alleviated to a logarithmic one. We show explicitly at one-loop level that the simpler definition with the non-dipolar Wilson links exhibits the same infrared behavior as the one with the dipolar Wilson links. The non-dipolar Wilson links are also introduced to the quasi-parton distribution function (QPDF) with an equal-time correlator in the large momentum limit, which can remove the involved linear divergence, and allow perturbative matching to the standard light-cone parton distribution function. The latter can then be extracted reliably from Euclidean lattice data for the QPDF with the non-dipolar Wilson links.

  14. How large is the gluon polarization in the statistical parton distributions approach?

    SciTech Connect

    Soffer, Jacques; Bourrely, Claude; Buccella, Franco

    2015-04-10

    We review the theoretical foundations of the quantum statistical approach to parton distributions and we show that by using some recent experimental results from Deep Inelastic Scattering, we are able to improve the description of the data by means of a new determination of the parton distributions. We will see that a large gluon polarization emerges, giving a significant contribution to the proton spin.

  15. Target Soil Impact Verification: Experimental Testing and Kayenta Constitutive Modeling.

    SciTech Connect

    Broome, Scott Thomas; Flint, Gregory Mark; Dewers, Thomas; Newell, Pania

    2015-11-01

    This report details experimental testing and constitutive modeling of sandy soil deformation under quasi - static conditions. This is driven by the need to understand constitutive response of soil to target/component behavior upon impact . An experimental and constitutive modeling program was followed to determine elastic - plastic properties and a compressional failure envelope of dry soil . One hydrostatic, one unconfined compressive stress (UCS), nine axisymmetric compression (ACS) , and one uniaxial strain (US) test were conducted at room temperature . Elastic moduli, assuming isotropy, are determined from unload/reload loops and final unloading for all tests pre - failure and increase monotonically with mean stress. Very little modulus degradation was discernable from elastic results even when exposed to mean stresses above 200 MPa . The failure envelope and initial yield surface were determined from peak stresses and observed onset of plastic yielding from all test results. Soil elasto - plastic behavior is described using the Brannon et al. (2009) Kayenta constitutive model. As a validation exercise, the ACS - parameterized Kayenta model is used to predict response of the soil material under uniaxial strain loading. The resulting parameterized and validated Kayenta model is of high quality and suitable for modeling sandy soil deformation under a range of conditions, including that for impact prediction.

  16. Target discrimination using computational vision human perception models

    NASA Astrophysics Data System (ADS)

    Lindquist, George H.; Witus, Gary; Cook, Thomas H.; Freeling, J. Richard; Gerhart, Grant R.

    1994-07-01

    The current DoD target acquisition models have two primary deficiencies: they use simplistic representations of the vehicle and background signatures, and a highly simplified description of the human observer. The current signature representation often fails for complex signature configurations, yields inaccurate detectability and marginal pay-off predictions for low signature vehicles, is not extensible to false alarms and temporal cues, and precludes vehicle design guidance and diagnosis. The current human observer model is simplified to the same degree as the signature representation, and as such is not extensible to high fidelity signature representations. In answer to the noted deficiencies, we have developed the TARDEC visual model (TVM). We have adopted an alternative approach that is based on emerging academic computational vision models (CVM). Our approach is tailored to visual signatures, though the model is applicable to thermal, SAR as well as other categories of imagery. Color imagery, input to the model, is initially transformed into a 3D color-opponent space comprising luminance, red-green, and yellow- blue axes. Each plane in the color-opponent space is then decomposed by local, oriented spatial frequency analyzers (Gabor or wavelet filters) in keeping with current knowledge of retinal/cortical processing. Signal-to-noise statistics are then calculated on each channel, appropriately aggregated over all channels, and used within the signal detection theory context to predict detection and false alarm probabilities.

  17. Cross sections for the exclusive photon electroproduction on the proton and Generalized Parton Distributions

    SciTech Connect

    Jo, Hyon -Suk

    2015-11-17

    Unpolarized and beam-polarized four-fold cross sections $\\frac{d^4 \\sigma}{dQ^2 dx_B dt d\\phi}$ for the $ep\\to e^\\prime p^\\prime \\gamma$ reaction were measured using the CLAS detector and the 5.75-GeV polarized electron beam of the Jefferson Lab accelerator, for 110 ($Q^2,x_B,t$) bins over the widest phase space ever explored in the valence-quark region. Several models of Generalized Parton Distributions (GPDs) describe the data well at most of our kinematics. This increases our confidence that we understand the GPD $H$, expected to be the dominant contributor to these observables. Thus, through a leading-twist extraction of Compton Form Factors, these results reveal a tomographic image of the nucleon.

  18. Cross sections for the exclusive photon electroproduction on the proton and Generalized Parton Distributions

    DOE PAGES

    Jo, Hyon -Suk

    2015-11-17

    Unpolarized and beam-polarized four-fold cross sectionsmore » $$\\frac{d^4 \\sigma}{dQ^2 dx_B dt d\\phi}$$ for the $$ep\\to e^\\prime p^\\prime \\gamma$$ reaction were measured using the CLAS detector and the 5.75-GeV polarized electron beam of the Jefferson Lab accelerator, for 110 ($$Q^2,x_B,t$$) bins over the widest phase space ever explored in the valence-quark region. Several models of Generalized Parton Distributions (GPDs) describe the data well at most of our kinematics. This increases our confidence that we understand the GPD $H$, expected to be the dominant contributor to these observables. Thus, through a leading-twist extraction of Compton Form Factors, these results reveal a tomographic image of the nucleon.« less

  19. Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models

    PubMed Central

    Ma, Huifa; Tian, Yongsheng; Yu, Xiangyang

    2017-01-01

    Background The Hedgehog pathway receptor smoothened (SMO) has critical roles in tumor progression. However, whether SMO is a key factor regulating gastric cancer chemotherapy resistance is unknown. Material/Methods We investigated the potential functions of SMO in inducing gastric cancer paclitaxel resistance in clinical samples, gastric cancer cell lines (424GC and AGS), and subcutaneous syngeneic mouse models. Results We found high SMO expression in paclitaxel-resistant gastric cancer clinical samples. Paclitaxel gastric cancer cells had higher SMO expression than in drug-sensitive cells. Upregulating SMO expression induced paclitaxel resistance in gastric cells lines via enhancing cell proliferation and inhibiting apoptosis. The combination of IPI-926, an inhibitor of SMO, with paclitaxel decreased cell viability of paclitaxel-resistant gastric cancer cells in vitro and controlled tumor growth in animal models. Conclusions The Hedgehog pathway receptor SMO is an important regulator of gastric cancer paclitaxel resistance and could be a target for sensitizing paclitaxel-resistant tumors. PMID:28350784

  20. Dissecting OCD Circuits: From Animal Models to Targeted Treatments

    PubMed Central

    Ahmari, Susanne E.; Dougherty, Darin D.

    2015-01-01

    Obsessive Compulsive Disorder (OCD) is a chronic, severe mental illness with up to 2–3% prevalence worldwide, which has been classified as one of the world’s 10 leading causes of illness-related disability according to the World Health Organization, largely because of the chronic nature of disabling symptoms 1. Despite the severity and high prevalence of this chronic and disabling disorder, there is still relatively limited understanding of its pathophysiology. However, this is now rapidly changing due to development of powerful technologies that can be used to dissect the neural circuits underlying pathologic behaviors. In this article, we describe recent technical advances that have allowed neuroscientists to start identifying the circuits underlying complex repetitive behaviors using animal model systems. In addition, we review current surgical and stimulation-based treatments for OCD that target circuit dysfunction. Finally, we discuss how findings from animal models may be applied in the clinical arena to help inform and refine targeted brain stimulation-based treatment approaches. PMID:25952989

  1. Target space pseudoduality in supersymmetric sigma models on symmetric spaces

    NASA Astrophysics Data System (ADS)

    Sarisaman, Mustafa

    We discuss the target space pseudoduality in supersymmetric sigma models on symmetric spaces. We first consider the case where sigma models based on real compact connected Lie groups of the same dimensionality and give examples using three dimensional models on target spaces. We show explicit construction of nonlocal conserved currents on the pseudodual manifold. We then switch the Lie group valued pseudoduality equations to Lie algebra valued ones, which leads to an infinite number of pseudoduality equations. We obtain an infinite number of conserved currents on the tangent bundle of the pseudo-dual manifold. Since pseudoduality imposes the condition that sigma models pseudodual to each other are based on symmetric spaces with opposite curvatures (i.e. dual symmetric spaces), we investigate pseudoduality transformation on the symmetric space sigma models in the third chapter. We see that there can be mixing of decomposed spaces with each other, which leads to mixings of the following expressions. We obtain the pseudodual conserved currents which are viewed as the orthonormal frame on the pullback bundle of the tangent space of G˜ which is the Lie group on which the pseudodual model based. Hence we obtain the mixing forms of curvature relations and one loop renormalization group beta function by means of these currents. In chapter four, we generalize the classical construction of pseudoduality transformation to supersymmetric case. We perform this both by component expansion method on manifold M and by orthonormal coframe method on manifold SO( M). The component method produces the result that pseudoduality transformation is not invertible at all points and occurs from all points on one manifold to only one point where riemann normal coordinates valid on the second manifold. Torsion of the sigma model on M must vanish while it is nonvanishing on M˜, and curvatures of the manifolds must be constant and the same because of anticommuting grassmann numbers. We obtain

  2. Likelihood of achieving air quality targets under model uncertainties.

    PubMed

    Digar, Antara; Cohan, Daniel S; Cox, Dennis D; Kim, Byeong-Uk; Boylan, James W

    2011-01-01

    Regulatory attainment demonstrations in the United States typically apply a bright-line test to predict whether a control strategy is sufficient to attain an air quality standard. Photochemical models are the best tools available to project future pollutant levels and are a critical part of regulatory attainment demonstrations. However, because photochemical models are uncertain and future meteorology is unknowable, future pollutant levels cannot be predicted perfectly and attainment cannot be guaranteed. This paper introduces a computationally efficient methodology for estimating the likelihood that an emission control strategy will achieve an air quality objective in light of uncertainties in photochemical model input parameters (e.g., uncertain emission and reaction rates, deposition velocities, and boundary conditions). The method incorporates Monte Carlo simulations of a reduced form model representing pollutant-precursor response under parametric uncertainty to probabilistically predict the improvement in air quality due to emission control. The method is applied to recent 8-h ozone attainment modeling for Atlanta, Georgia, to assess the likelihood that additional controls would achieve fixed (well-defined) or flexible (due to meteorological variability and uncertain emission trends) targets of air pollution reduction. The results show that in certain instances ranking of the predicted effectiveness of control strategies may differ between probabilistic and deterministic analyses.

  3. Transverse momentum-dependent parton distribution functions in lattice QCD

    SciTech Connect

    Engelhardt, Michael G.; Musch, Bernhard U.; Haegler, Philipp G.; Negele, John W.; Schaefer, Andreas

    2013-08-01

    A fundamental structural property of the nucleon is the distribution of quark momenta, both parallel as well as perpendicular to its propagation. Experimentally, this information is accessible via selected processes such as semi-inclusive deep inelastic scattering (SIDIS) and the Drell-Yan process (DY), which can be parametrized in terms of transversemomentum-dependent parton distributions (TMDs). On the other hand, these distribution functions can be extracted from nucleon matrix elements of a certain class of bilocal quark operators in which the quarks are connected by a staple-shaped Wilson line serving to incorporate initial state (DY) or final state (SIDIS) interactions. A scheme for evaluating such matrix elements within lattice QCD is developed. This requires casting the calculation in a particular Lorentz frame, which is facilitated by a parametrization of the matrix elements in terms of invariant amplitudes. Exploratory results are presented for the time-reversal odd Sivers and Boer-Mulders transverse momentum shifts.

  4. Transverse momentum-dependent parton distribution functions from lattice QCD

    SciTech Connect

    Michael Engelhardt, Philipp Haegler, Bernhard Musch, John Negele, Andreas Schaefer

    2012-12-01

    Transverse momentum-dependent parton distributions (TMDs) relevant for semi-inclusive deep inelastic scattering (SIDIS) and the Drell-Yan process can be defined in terms of matrix elements of a quark bilocal operator containing a staple-shaped Wilson connection. Starting from such a definition, a scheme to determine TMDs in lattice QCD is developed and explored. Parametrizing the aforementioned matrix elements in terms of invariant amplitudes permits a simple transformation of the problem to a Lorentz frame suited for the lattice calculation. Results for the Sivers and Boer-Mulders transverse momentum shifts are obtained using ensembles at the pion masses 369MeV and 518MeV, focusing in particular on the dependence of these shifts on the staple extent and a Collins-Soper-type evolution parameter quantifying proximity of the staples to the light cone.

  5. Global NLO Analysis of Nuclear Parton Distribution Functions

    SciTech Connect

    Hirai, M.; Kumano, S.; Nagai, T.-H.

    2008-02-21

    Nuclear parton distribution functions (NPDFs) are determined by a global analysis of experimental measurements on structure-function ratios F{sub 2}{sup A}/F{sub 2}{sup A{sup '}} and Drell-Yan cross section ratios {sigma}{sub DY}{sup A}/{sigma}{sub DY}{sup A{sup '}}, and their uncertainties are estimated by the Hessian method. The NPDFs are obtained in both leading order (LO) and next-to-leading order (NLO) of {alpha}{sub s}. As a result, valence-quark distributions are relatively well determined, whereas antiquark distributions at x>0.2 and gluon distributions in the whole x region have large uncertainties. The NLO uncertainties are slightly smaller than the LO ones; however, such a NLO improvement is not as significant as the nucleonic case.

  6. Double parton effects for jets with large rapidity separation

    SciTech Connect

    Szczurek, Antoni; Cisek, Anna; Maciuła, Rafal

    2015-04-10

    We discuss production of four jets pp → jjjjX with at least two jets with large rapidity separation in proton-proton collisions at the LHC through the mechanism of double-parton scattering (DPS). The cross section is calculated in a factorizaed approximation. Each hard subprocess is calculated in LO collinear approximation. The LO pQCD calculations are shown to give a reasonably good descritption of CMS and ATLAS data on inclusive jet production. It is shown that relative contribution of DPS is growing with increasing rapidity distance between the most remote jets, center-of-mass energy and with decreasing (mini)jet transverse momenta. We show also result for angular azimuthal dijet correlations calculated in the framework of k{sub t} -factorization approximation.

  7. Human endotoxemia: a model for mechanistic insight and therapeutic targeting.

    PubMed

    Lowry, Stephen F

    2005-12-01

    The diversity of phenotypic manifestations, comorbidities, and therapeutic algorithms in patients with severe inflammation have confounded efforts to translate mechanistic insights from the bench top to the bedside. This dilemma has negatively impacted upon many therapeutic interventions that exhibited seemingly well-reasoned preclinical portfolios. Prudence urges the assessment of potent immunoregulatory therapies, wherever possible, in models that replicate the clinical phenotype absent overt manifestations of genetically or environmentally modified processes. The healthy human model of endotoxin administration (systemic or endobronchial) provides such an opportunity and has been used to great advantage for gaining insight into mechanisms of disease and for determination of therapeutic signal strength. When thoughtfully interpreted, the model may provide proof of principle as well as lessen the unpredictability of clinical responses. Although the broad characteristics of this model are well described in the literature, it is recognized that this model does not fully replicate the magnitude of initial inflammatory stress nor the latent spectrum of inflammation/sepsis-inducible organ system pathologies. Nevertheless, the similarities between the early, transient clinical phenotype, inducible physiochemical change, and biochemical pathway activation of this model to the early hyperdynamic phase of resuscitated injury and infection are striking. Rational testing of a therapeutic mechanism requires a quantifiable and reproducibly altered marker of the hypothetical mechanism. Given the modest nature of endotoxin induced insult, interventions that demonstrate target specific efficacy in conjunction with attenuated phenotype responses are more likely to exhibit efficacy within lower risk patient populations. By contrast, the model cannot predict clinical efficacy among higher risk patients nor in those who have endured extended periods of inflammatory stress.

  8. Investigating GPDs in the framework of the double distribution model

    NASA Astrophysics Data System (ADS)

    Nazari, F.; Mirjalili, A.

    2016-06-01

    In this paper, we construct the generalized parton distribution (GPD) in terms of the kinematical variables x, ξ, t, using the double distribution model. By employing these functions, we could extract some quantities which makes it possible to gain a three-dimensional insight into the nucleon structure function at the parton level. The main objective of GPDs is to combine and generalize the concepts of ordinary parton distributions and form factors. They also provide an exclusive framework to describe the nucleons in terms of quarks and gluons. Here, we first calculate, in the Double Distribution model, the GPD based on the usual parton distributions arising from the GRV and CTEQ phenomenological models. Obtaining quarks and gluons angular momenta from the GPD, we would be able to calculate the scattering observables which are related to spin asymmetries of the produced quarkonium. These quantities are represented by AN and ALS. We also calculate the Pauli and Dirac form factors in deeply virtual Compton scattering. Finally, in order to compare our results with the existing experimental data, we use the difference of the polarized cross-section for an initial longitudinal leptonic beam and unpolarized target particles (ΔσLU). In all cases, our obtained results are in good agreement with the available experimental data.

  9. Informing pedagogy through the brain-targeted teaching model.

    PubMed

    Hardiman, Mariale

    2012-01-01

    Improving teaching to foster creative thinking and problem-solving for students of all ages will require two essential changes in current educational practice. First, to allow more time for deeper engagement with material, it is critical to reduce the vast number of topics often required in many courses. Second, and perhaps more challenging, is the alignment of pedagogy with recent research on cognition and learning. With a growing focus on the use of research to inform teaching practices, educators need a pedagogical framework that helps them interpret and apply research findings. This article describes the Brain-Targeted Teaching Model, a scheme that relates six distinct aspects of instruction to research from the neuro- and cognitive sciences.

  10. Informing Pedagogy Through the Brain-Targeted Teaching Model

    PubMed Central

    Hardiman, Mariale

    2012-01-01

    Improving teaching to foster creative thinking and problem-solving for students of all ages will require two essential changes in current educational practice. First, to allow more time for deeper engagement with material, it is critical to reduce the vast number of topics often required in many courses. Second, and perhaps more challenging, is the alignment of pedagogy with recent research on cognition and learning. With a growing focus on the use of research to inform teaching practices, educators need a pedagogical framework that helps them interpret and apply research findings. This article describes the Brain-Targeted Teaching Model, a scheme that relates six distinct aspects of instruction to research from the neuro- and cognitive sciences. PMID:23653775

  11. Target detection in hyperspectral imagery using forward modeling and in-scene information

    NASA Astrophysics Data System (ADS)

    Axelsson, Maria; Friman, Ola; Haavardsholm, Trym Vegard; Renhorn, Ingmar

    2016-09-01

    This work addresses the problem of detecting and classifying materials and targets in hyperspectral images based on their reflectance spectrum. Accurate target detection in hyperspectral imagery requires a radiative transfer model that maps between the spectral reflectance domain and the measured radiance domain. Such a model can be employed in two ways for detection - using atmospheric compensation, where the measured hyperspectral radiance image is converted to a reflectance image, and using forward modeling, where the target reflectance spectrum is converted to an at-sensor target radiance spectrum. This work presents a forward modeling detection method that utilizes in-scene information to estimate the parameters in the radiative transfer model. Uncertainty in the radiative transfer model and variability of the target spectra are captured using a constrained subspace model for the target. Target detection using library spectra and target rediscovery are evaluated in hyperspectral images of a complex urban scene.

  12. Virtual photon structure functions and the parton content of the electron

    SciTech Connect

    Drees, M. ); Godbole, R.M. )

    1994-09-01

    We point out that in processes involving the parton content of the photon the usual effective photon approximation should be modified. The reason is that the parton content of virtual photons is logarithmically suppressed compared to real photons. We describe this suppression using several simple, physically motivated [ital Ansa]$[ital uml---tze]. Although the parton content of the electron in general no longer factorizes into an electron flux function and a photon structure function, it can still be expressed as a single integral. Numerical examples are given for the [ital e][sup +][ital e][sup [minus

  13. Airborne electromagnetic modelling options and their consequences in target definition

    NASA Astrophysics Data System (ADS)

    Ley-Cooper, Alan Yusen; Viezzoli, Andrea; Guillemoteau, Julien; Vignoli, Giulio; Macnae, James; Cox, Leif; Munday, Tim

    2015-10-01

    Given the range of geological conditions under which airborne EM surveys are conducted, there is an expectation that the 2D and 3D methods used to extract models that are geologically meaningful would be favoured over 1D inversion and transforms. We do after all deal with an Earth that constantly undergoes, faulting, intrusions, and erosive processes that yield a subsurface morphology, which is, for most parts, dissimilar to a horizontal layered earth. We analyse data from a survey collected in the Musgrave province, South Australia. It is of particular interest since it has been used for mineral prospecting and for a regional hydro-geological assessment. The survey comprises abrupt lateral variations, more-subtle lateral continuous sedimentary sequences and filled palaeovalleys. As consequence, we deal with several geophysical targets of contrasting conductivities, varying geometries and at different depths. We invert the observations by using several algorithms characterised by the different dimensionality of the forward operator. Inversion of airborne EM data is known to be an ill-posed problem. We can generate a variety of models that numerically adequately fit the measured data, which makes the solution non-unique. The application of different deterministic inversion codes or transforms to the same dataset can give dissimilar results, as shown in this paper. This ambiguity suggests the choice of processes and algorithms used to interpret AEM data cannot be resolved as a matter of personal choice and preference. The degree to which models generated by a 1D algorithm replicate/or not measured data, can be an indicator of the data's dimensionality, which perse does not imply that data that can be fitted with a 1D model cannot be multidimensional. On the other hand, it is crucial that codes that can generate 2D and 3D models do reproduce the measured data in order for them to be considered as a plausible solution. In the absence of ancillary information, it could

  14. Cellular communication and “non-targeted effects”: Modelling approaches

    NASA Astrophysics Data System (ADS)

    Ballarini, Francesca; Facoetti, Angelica; Mariotti, Luca; Nano, Rosanna; Ottolenghi, Andrea

    2009-10-01

    During the last decade, a large number of experimental studies on the so-called "non-targeted effects", in particular bystander effects, outlined that cellular communication plays a significant role in the pathways leading to radiobiological damage. Although it is known that two main types of cellular communication (i.e. via gap junctions and/or molecular messengers diffusing in the extra-cellular environment, such as cytokines, NO etc.) play a major role, it is of utmost importance to better understand the underlying mechanisms, and how such mechanisms can be modulated by ionizing radiation. Though the "final" goal is of course to elucidate the in vivo scenario, in the meanwhile also in vitro studies can provide useful insights. In the present paper we will discuss key issues on the mechanisms underlying non-targeted effects and cell communication, for which theoretical models and simulation codes can be of great help. In this framework, we will present in detail three literature models, as well as an approach under development at the University of Pavia. More specifically, we will first focus on a version of the "State-Vector Model" including bystander-induced apoptosis of initiated cells, which was successfully fitted to in vitro data on neoplastic transformation supporting the hypothesis of a protective bystander effect mediated by apoptosis. The second analyzed model, focusing on the kinetics of bystander effects in 3D tissues, was successfully fitted to data on bystander damage in an artificial 3D skin system, indicating a signal range of the order of 0.7-1 mm. A third model for bystander effect, taking into account of spatial location, cell killing and repopulation, showed dose-response curves increasing approximately linearly at low dose rates but quickly flattening out for higher dose rates, also predicting an effect augmentation following dose fractionation. Concerning the Pavia approach, which can model the release, diffusion and depletion/degradation of

  15. Single perturbative splitting diagrams in double parton scattering

    NASA Astrophysics Data System (ADS)

    Gaunt, Jonathan R.

    2013-01-01

    We present a detailed study of a specific class of graph that can potentially contribute to the proton-proton double parton scattering (DPS) cross section. These are the `2v1' or `single perturbative splitting' graphs, in which two `nonperturbatively generated' ladders interact with two ladders that have been generated via a perturbative 1 → 2 branching process. Using a detailed calculation, we confirm the result written down originally by Ryskin and Snigirev — namely, that the 2v1 graphs in which the two nonperturbatively generated ladders do not interact with one another do contribute to the leading order proton-proton DPS cross section, albeit with a different geometrical prefactor to the one that applies to the `2v2'/`zero perturbative splitting' graphs. We then show that 2v1 graphs in which the `nonperturbatively generated' ladders exchange partons with one another also contribute to the leading order proton-proton DPS cross section, provided that this `crosstalk' occurs at a lower scale than the 1 → 2 branching on the other side of the graph. Due to the preference in the 2v1 graphs for the x value at which the branching occurs, and crosstalk ceases, to be very much larger than the x values at the hard scale, the effect of crosstalk interactions is likely to be a decrease in the 2v1 cross section except at exceedingly small x values (≲ 10-6). At moderate x values ≃ 10-3 -10-2, the x value at the splitting is in the region ≃ 10-1 where PDFs do not change much with scale, and the effect of crosstalk interactions is likely to be small. We give an explicit formula for the contribution from the 2v1 graphs to the DPS cross section, and combine this with a suggestion that we made in a previous publication, that the `double perturbative splitting'/`1v1' graphs should be completely removed from the DPS cross section, to obtain a formula for the DPS cross section. It is pointed out that there are two potentially concerning features in this equation, that

  16. Prompt photon photoproduction at HERA with non-collinear parton dynamics

    SciTech Connect

    Lipatov, A. V.; Zotov, N. P.

    2011-07-15

    We investigate the prompt photon photoproduction at HERA within the framework of the k{sub T}-factorization approach to QCD. Our consideration is based on the off-shell matrix elements for the underlying partonic subprocesses and the Kimber-Martin-Ryskin (KMR) unintegrated parton densities in the proton. We also use the Ciafaloni-Catani-Fiorani-Marchesini (CCFM) unintegrated gluon as well as valence and sea quark distributions.

  17. The application of antitumor drug-targeting models on liver cancer.

    PubMed

    Yan, Yan; Chen, Ningbo; Wang, Yunbing; Wang, Ke

    2016-06-01

    Hepatocarcinoma animal models, such as the induced tumor model, transplanted tumor model, gene animal model, are significant experimental tools for the evaluation of targeting drug delivery system as well as the pre-clinical studies of liver cancer. The application of antitumor drug-targeting models not only furnishes similar biological characteristics to human liver cancer but also offers guarantee of pharmacokinetic indicators of the liver-targeting preparations. In this article, we have reviewed some kinds of antitumor drug-targeting models of hepatoma and speculated that the research on this field would be capable of attaining a deeper level and expecting a superior achievement in the future.

  18. Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.

    PubMed

    French, Dorothy M; Lin, Benjamin C; Wang, Manping; Adams, Camellia; Shek, Theresa; Hötzel, Kathy; Bolon, Brad; Ferrando, Ronald; Blackmore, Craig; Schroeder, Kurt; Rodriguez, Luis A; Hristopoulos, Maria; Venook, Rayna; Ashkenazi, Avi; Desnoyers, Luc R

    2012-01-01

    The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental and physiological processes. It is also well documented that dysregulation of FGF-FGFR signaling may have important roles in tumor development and progression. The FGFR4-FGF19 signaling axis has been implicated in the development of hepatocellular carcinomas (HCCs) in mice, and potentially in humans. In this study, we demonstrate that FGFR4 is required for hepatocarcinogenesis; the progeny of FGF19 transgenic mice, which have previously been shown to develop HCCs, bred with FGFR4 knockout mice fail to develop liver tumors. To further test the importance of FGFR4 in HCC, we developed a blocking anti-FGFR4 monoclonal antibody (LD1). LD1 inhibited: 1) FGF1 and FGF19 binding to FGFR4, 2) FGFR4-mediated signaling, colony formation, and proliferation in vitro, and 3) tumor growth in a preclinical model of liver cancer in vivo. Finally, we show that FGFR4 expression is elevated in several types of cancer, including liver cancer, as compared to normal tissues. These findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease.

  19. Automated parton-shower variations in pythia 8

    NASA Astrophysics Data System (ADS)

    Mrenna, S.; Skands, P.

    2016-10-01

    In the era of precision physics measurements at the LHC, efficient and exhaustive estimations of theoretical uncertainties play an increasingly crucial role. In the context of Monte Carlo (MC) event generators, the estimation of such uncertainties traditionally requires independent MC runs for each variation, for a linear increase in total run time. In this work, we report on an automated evaluation of the dominant (renormalization-scale and nonsingular) perturbative uncertainties in the pythia 8 event generator, with only a modest computational overhead. Each generated event is accompanied by a vector of alternative weights (one for each uncertainty variation), with each set separately preserving the total cross section. Explicit scale-compensating terms can be included, reflecting known coefficients of higher-order splitting terms and reducing the effect of the variations. The formalism also allows for the enhancement of rare partonic splittings, such as g →b b ¯ and q →q γ , to obtain weighted samples enriched in these splittings while preserving the correct physical Sudakov factors.

  20. Automated parton-shower variations in PYTHIA 8

    SciTech Connect

    Mrenna, S.; Skands, P.

    2016-10-03

    In the era of precision physics measurements at the LHC, efficient and exhaustive estimations of theoretical uncertainties play an increasingly crucial role. In the context of Monte Carlo (MC) event generators, the estimation of such uncertainties traditionally requires independent MC runs for each variation, for a linear increase in total run time. In this work, we report on an automated evaluation of the dominant (renormalization-scale and nonsingular) perturbative uncertainties in the pythia 8 event generator, with only a modest computational overhead. Each generated event is accompanied by a vector of alternative weights (one for each uncertainty variation), with each set separately preserving the total cross section. Explicit scale-compensating terms can be included, reflecting known coefficients of higher-order splitting terms and reducing the effect of the variations. In conclusion, the formalism also allows for the enhancement of rare partonic splittings, such as g→bb¯ and q→qγ, to obtain weighted samples enriched in these splittings while preserving the correct physical Sudakov factors.

  1. Automated parton-shower variations in PYTHIA 8

    DOE PAGES

    Mrenna, S.; Skands, P.

    2016-10-03

    In the era of precision physics measurements at the LHC, efficient and exhaustive estimations of theoretical uncertainties play an increasingly crucial role. In the context of Monte Carlo (MC) event generators, the estimation of such uncertainties traditionally requires independent MC runs for each variation, for a linear increase in total run time. In this work, we report on an automated evaluation of the dominant (renormalization-scale and nonsingular) perturbative uncertainties in the pythia 8 event generator, with only a modest computational overhead. Each generated event is accompanied by a vector of alternative weights (one for each uncertainty variation), with each set separatelymore » preserving the total cross section. Explicit scale-compensating terms can be included, reflecting known coefficients of higher-order splitting terms and reducing the effect of the variations. In conclusion, the formalism also allows for the enhancement of rare partonic splittings, such as g→bb¯ and q→qγ, to obtain weighted samples enriched in these splittings while preserving the correct physical Sudakov factors.« less

  2. Energy flow along the medium-induced parton cascade

    SciTech Connect

    Blaizot, J.-P.

    2016-05-15

    We discuss the dynamics of parton cascades that develop in dense QCD matter, and contrast their properties with those of similar cascades of gluon radiation in vacuum. We argue that such cascades belong to two distinct classes that are characterized respectively by an increasing or a constant (or decreasing) branching rate along the cascade. In the former class, of which the BDMPS, medium-induced, cascade constitutes a typical example, it takes a finite time to transport a finite amount of energy to very soft quanta, while this time is essentially infinite in the latter case, to which the DGLAP cascade belongs. The medium induced cascade is accompanied by a constant flow of energy towards arbitrary soft modes, leading eventually to the accumulation of the initial energy of the leading particle at zero energy. It also exhibits scaling properties akin to wave turbulence. These properties do not show up in the cascade that develops in vacuum. There, the energy accumulates in the spectrum at smaller and smaller energy as the cascade develops, but the energy never flows all the way down to zero energy. Our analysis suggests that the way the energy is shared among the offsprings of a splitting gluon has little impact on the qualitative properties of the cascades, provided the kernel that governs the splittings is not too singular.

  3. Modeling to Support the Development of Habitat Targets for Piping Plovers on the Missouri River

    SciTech Connect

    Buenau, Kate E.

    2015-05-05

    Report on modeling and analyses done in support of developing quantative sandbar habitat targets for piping plovers, including assessment of reference, historical, dams present but not operated, and habitat construction calibrated to meet population viability targets.

  4. Statistical and Modeling Uncertainties in the Thermal Target Acquisition Model Improvement Program (TAMIP) Predictions.

    DTIC Science & Technology

    1995-09-01

    predictor variable which are unbiased in the sense that they are accurate at both high and low detection probabilities. We validate the confidence ... interval using a second data set that was not used in the development of this phase of the target detection model.

  5. Feature Extraction Using Attributed Scattering Center Models for Model-Based Automatic Target Recognition (ATR)

    DTIC Science & Technology

    2005-10-01

    systems employing synthetic aperture radar . This report summarizes the major technical accomplishments that were realized. We developed a set of...automatic target recognition, ATR performance prediction, synthetic aperture radar 16. SECURITY CLASSIFICATION OF: 19a. NAME OF RESPONSIBLE PERSON...Std. Z39-18 Contents 1 INTRODUCTION 1 2 ATTRIBUTED SCATTERING MODELS FOR SYNTHETIC APER- TURE RADAR 6 2.1 Introduction

  6. The Targeting Task Performance (TTP) Metric A New Model for Predicting Target Acquisition Performance

    DTIC Science & Technology

    2006-05-31

    patterns for eyeball measurements, and the use of sinewaves is consistent with our sensor model. Fourier theory is used to model system blur and noise...behavior into the Fourier frequency domain model. It is understood that sinewave measurements are not practical in the laboratory. However, there is...Laboratory Static Performance Model (Ratches 1975, 1976, and 2001). The NVL model used Fourier transform theory and communications theory concepts

  7. NLC Polarized Positron Photon Beam Target Thermal Structural Modeling

    SciTech Connect

    Stein, W; Sheppard, J C

    2002-06-11

    The NLC polarized positron photon beam target is a 0.4 radiation length thick titanium target. Energy deposition from one pulse occurs over 266 nano-seconds and results in heating of the target and pressure pulses straining the material. The 22.1 MeV photon beam has a spot size of 0.75 mm and results in a maximum temperature jump of 233 C. Stresses are induced in the material from thermal expansion of the hotter material. Peak effective stresses reach 19 Ksi (1.34 x 10{sup 8} Pa), which is lower than the yield strength of a titanium alloy by a factor of six.

  8. Application of custom tools and algorithms to the development of terrain and target models

    NASA Astrophysics Data System (ADS)

    Wilkosz, Aaron; Williams, Bryan L.; Motz, Steve

    2003-09-01

    In this paper we give a high level discussion outlining methodologies and techniques employed in generating high fidelity terrain and target models. We present the current state of our IR signature development efforts, cover custom tools and algorithms, and discuss future plans. We outline the steps required to derive an IR terrain and target signature models, and provide some details about algorithms developed to classify aerial imagery. In addition, we discuss our tool used to apply IR signature data to tactical vehicle models. We discuss how we process the empirical IR data of target vehicles, apply it to target models, and generate target signature models that correlate with the measured calibrated IR data. The developed characterization databases and target models are used in digital simulations by various customers within the US Army Aviation and Missile Command (AMCOM).

  9. Electromagnetic modelling of Ground Penetrating Radar responses to complex targets

    NASA Astrophysics Data System (ADS)

    Pajewski, Lara; Giannopoulos, Antonis

    2014-05-01

    defined through a constant real value, or else its frequency-dispersion properties can be taken into account by incorporating into the model Debye approximations. The electromagnetic source can be represented as a simple line of current (in the case of two-dimensional models), a Hertzian dipole, a bow tie antenna, or else, the realistic description of a commercial antenna can be included in the model [2]. Preliminary results for some of the proposed cells are presented, obtained by using GprMax [3], a freeware tool which solves Maxwell's equations by using a second order in space and time Finite-Difference Time-Domain algorithm. B-Scans and A-Scans are calculated at 1.5 GHz, for the total electric field and for the field back-scattered by targets embedded in the cells. A detailed description of the structures, together with the relevant numerical results obtained to date, are available for the scientific community on the website of COST Action TU1208, www.GPRadar.eu. Research groups working on the development of electromagnetic forward- and inverse-scattering techniques, as well as on imaging methods, might test and compare the accuracy and applicability of their approaches on the proposed set of scenarios. The aim of this initiative is not that of identifying the best methods, but more properly to indicate the range of reliability of each approach, highlighting its advantages and drawbacks. In the future, the realisation of the proposed concrete cells and the acquisition of GPR experimental data would allow a very effective benchmark for forward and inverse scattering methods. References [1] R. Yelf, A. Ward, "Nine steps to concrete wisdom." Proc. 13th International Conference on Ground Penetrating Radar, Lecce, Italy, 21-25 June 2010, pp. 1-8. [2] C. Warren, A. Giannopoulos, "Creating FDTD models of commercial GPR antennas using Taguchi's optimisation method." Geophysics (2011), 76, article ID G37. [3] A. Giannopoulos, "Modelling ground penetrating radar by GPRMAX

  10. How Bright is the Proton? A Precise Determination of the Photon Parton Distribution Function

    NASA Astrophysics Data System (ADS)

    Manohar, Aneesh; Nason, Paolo; Salam, Gavin P.; Zanderighi, Giulia

    2016-12-01

    It has become apparent in recent years that it is important, notably for a range of physics studies at the Large Hadron Collider, to have accurate knowledge on the distribution of photons in the proton. We show how the photon parton distribution function (PDF) can be determined in a model-independent manner, using electron-proton (e p ) scattering data, in effect viewing the e p →e +X process as an electron scattering off the photon field of the proton. To this end, we consider an imaginary, beyond the Standard Model process with a flavor changing photon-lepton vertex. We write its cross section in two ways: one in terms of proton structure functions, the other in terms of a photon distribution. Requiring their equivalence yields the photon distribution as an integral over proton structure functions. As a result of the good precision of e p data, we constrain the photon PDF at the level of 1%-2% over a wide range of momentum fractions.

  11. The difficulty in measuring suitable targets when modeling victimization.

    PubMed

    Popp, Ann Marie

    2012-01-01

    Target suitability is a critical theoretical concept for opportunity theory. Previous research has primarily measured this concept using demographic characteristics of the study participant, which is problematic. This study corrects the measurement problem by employing bullying variables as alternative measures of target suitability because they are arguably better at capturing the social and psychological vulnerability of the individual that is attracting motivated offenders. Using three waves (1999, 2001, & 2003) of the National Crime Victimization Survey (NCVS) School Crime Supplement (SCS), this research explores the impact of the bullying measures along with demographic characteristics and lifestyle measures on the likelihood that a student will experience victimization in school. The findings suggest that the bullying measures are better predictors of victimization over the demographic characteristics and lifestyle measures for all three waves. The findings highlight the need for better measures of target suitability, which capture the social and psychological vulnerability of victims to explain victimization.

  12. Principles of miRNA-Target Regulation in Metazoan Models

    PubMed Central

    Doxakis, Epaminondas

    2013-01-01

    MicroRNAs (miRs) are key post-transcriptional regulators that silence gene expression by direct base pairing to target sites of RNAs. They have a wide variety of tissue expression patterns and are differentially expressed during development and disease. Their activity and abundance is subject to various levels of control ranging from transcription and biogenesis to miR response elements on RNAs, target cellular levels and miR turnover. This review summarizes and discusses current knowledge on the regulation of miR activity and concludes with novel non-canonical functions that have recently emerged. PMID:23965954

  13. Ovarian Mouse Models with Targeted Fallopian Tubal Carcinogenesis

    DTIC Science & Technology

    2013-09-01

    target genetic deletions to the oviductal epithelium. We are currently performing selective genetic deletion of ovarian cancer genes, such as TP53 ...fallopian epithelium, oviductal epithelium, BRCA1, Rb, TP53 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES

  14. Modeling Criterion Shifts and Target Checking in Prospective Memory Monitoring

    ERIC Educational Resources Information Center

    Horn, Sebastian S.; Bayen, Ute J.

    2015-01-01

    Event-based prospective memory (PM) involves remembering to perform intended actions after a delay. An important theoretical issue is whether and how people monitor the environment to execute an intended action when a target event occurs. Performing a PM task often increases the latencies in ongoing tasks. However, little is known about the…

  15. Spin correlations in the Drell–Yan process, parton entanglement, and other unconventional QCD effects

    SciTech Connect

    Nachtmann, O.

    2014-11-15

    We review ideas on the structure of the QCD vacuum which had served as motivation for the discussion of various non-standard QCD effects in high-energy reactions in articles from 1984 to 1995. These effects include, in particular, transverse-momentum and spin correlations in the Drell–Yan process and soft photon production in hadron–hadron collisions. We discuss the relation of the approach introduced in the above-mentioned articles to the approach, developed later, using transverse-momentum-dependent parton distributions (TDMs). The latter approach is a special case of our more general one which allows for parton entanglement in high-energy reactions. We discuss signatures of parton entanglement in the Drell–Yan reaction. Also for Higgs-boson production in pp collisions via gluon–gluon annihilation effects of entanglement of the two gluons are discussed and are found to be potentially important. These effects can be looked for in the current LHC experiments. In our opinion studying parton-entanglement effects in high-energy reactions is, on the one hand, very worthwhile by itself and, on the other hand, it allows to perform quantitative tests of standard factorisation assumptions. Clearly, the experimental observation of parton-entanglement effects in the Drell–Yan reaction and/or in Higgs-boson production would have a great impact on our understanding how QCD works in high-energy collisions.

  16. Modeling and validation of photometric characteristics of space targets oriented to space-based observation.

    PubMed

    Wang, Hongyuan; Zhang, Wei; Dong, Aotuo

    2012-11-10

    A modeling and validation method of photometric characteristics of the space target was presented in order to track and identify different satellites effectively. The background radiation characteristics models of the target were built based on blackbody radiation theory. The geometry characteristics of the target were illustrated by the surface equations based on its body coordinate system. The material characteristics of the target surface were described by a bidirectional reflectance distribution function model, which considers the character of surface Gauss statistics and microscale self-shadow and is obtained by measurement and modeling in advance. The contributing surfaces of the target to observation system were determined by coordinate transformation according to the relative position of the space-based target, the background radiation sources, and the observation platform. Then a mathematical model on photometric characteristics of the space target was built by summing reflection components of all the surfaces. Photometric characteristics simulation of the space-based target was achieved according to its given geometrical dimensions, physical parameters, and orbital parameters. Experimental validation was made based on the scale model of the satellite. The calculated results fit well with the measured results, which indicates the modeling method of photometric characteristics of the space target is correct.

  17. Joint tracking algorithm using particle filter and mean shift with target model updating

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Tian, Weifeng; Jin, Zhihua

    2006-10-01

    Roughly, visual tracking algorithms can be divided into two main classes: deterministic tracking and stochastic tracking. Mean shift and particle filter are their typical representatives, respectively. Recently, a hybrid tracker, seamlessly integrating the respective advantages of mean shift and particle filter (MSPF) has achieved impressive success in robust tracking. The pivot of MSPF is to sample fewer particles using particle filter and then those particles are shifted to their respective local maximum of target searching space by mean shift. MSPF not only can greatly reduce the number of particles that particle filter required, but can remedy the deficiency of mean shift. Unfortunately, due to its inherent principle, MSPF is restricted to those applications with little changes of the target model. To make MSPF more flexible and robust, an adaptive target model is extended to MSPF in this paper. Experimental results show that MSPF with target model updating can robustly track the target through the whole sequences regardless of the change of target model.

  18. Continuum fusion solutions for replacement target models in electro-optic detection.

    PubMed

    Schaum, Alan

    2014-05-01

    The additive target model is used routinely in the statistical detection of opaque targets, despite its phenomenological inaccuracy. The more appropriate replacement target model is seldom used, because the standard method for producing a detection algorithm from it proves to be intractable, unless narrow restrictions are imposed. Now, the recently developed continuum fusion (CF) methodology allows an expanded solution set to the general replacement target problem. It also provides a mechanism for producing approximate solutions for the standard approach. We illustrate the principles of CF by using them to generate both types of answers for the correct detection model.

  19. Parton shower uncertainties in jet substructure analyses with deep neural networks

    NASA Astrophysics Data System (ADS)

    Barnard, James; Dawe, Edmund Noel; Dolan, Matthew J.; Rajcic, Nina

    2017-01-01

    Machine learning methods incorporating deep neural networks have been the subject of recent proposals for new hadronic resonance taggers. These methods require training on a data set produced by an event generator where the true class labels are known. However, this may bias the network towards learning features associated with the approximations to QCD used in that generator which are not present in real data. We therefore investigate the effects of variations in the modeling of the parton shower on the performance of deep neural network taggers using jet images from hadronic W bosons at the LHC, including detector-related effects. By investigating network performance on samples from the Pythia, Herwig and Sherpa generators, we find differences of up to 50% in background rejection for fixed signal efficiency. We also introduce and study a method, which we dub zooming, for implementing scale invariance in neural-network-based taggers. We find that this leads to an improvement in performance across a wide range of jet transverse momenta. Our results emphasize the importance of gaining a detailed understanding of what aspects of jet physics these methods are exploiting.

  20. A Modeling Method of Multiple Targets Assignment under Multiple UAVs’ Cooperation

    NASA Astrophysics Data System (ADS)

    Wang, Q. H.; Wan, G.; Cao, X. F.; Xie, L. X.

    2017-03-01

    Aiming at the multiple UAVs’ cooperation in the complex environment, detailed analysis about targets assignment model is made in the paper. Firstly, three basic situations are discussed according to the quantitative relationship between the UAVs and the targets. Then in order to make the targets model more practical, the probability that the UAVs’ damage is also taken into consideration. Following, basic particle swarm optimization algorithm is adopted to solve the model which has great performance in efficiency and convergence. Finally, three-dimensional environment is simulated to verify the model. Simulation results show that the model is practical and close to the actual environment.

  1. Testing Measurement Invariance in the Target Rotated Multigroup Exploratory Factor Model

    ERIC Educational Resources Information Center

    Dolan, Conor V.; Oort, Frans J.; Stoel, Reinoud D.; Wicherts, Jelte M.

    2009-01-01

    We propose a method to investigate measurement invariance in the multigroup exploratory factor model, subject to target rotation. We consider both oblique and orthogonal target rotation. This method has clear advantages over other approaches, such as the use of congruence measures. We demonstrate that the model can be implemented readily in the…

  2. QCD-aware partonic jet clustering for truth-jet flavour labelling

    NASA Astrophysics Data System (ADS)

    Buckley, Andy; Pollard, Chris

    2016-02-01

    We present an algorithm for deriving partonic flavour labels to be applied to truth particle jets in Monte Carlo event simulations. The inputs to this approach are final pre-hadronisation partons, to remove dependence on unphysical details such as the order of matrix element calculation and shower generator frame recoil treatment. These are clustered using standard jet algorithms, modified to restrict the allowed pseudojet combinations to those in which tracked flavour labels are consistent with QCD and QED Feynman rules. The resulting algorithm is shown to be portable between the major families of shower generators, and largely insensitive to many possible systematic variations: it hence offers significant advantages over existing ad hoc labelling schemes. However, it is shown that contamination from multi-parton scattering simulations can disrupt the labelling results. Suggestions are made for further extension to incorporate more detailed QCD splitting function kinematics, robustness improvements, and potential uses for truth-level physics object definitions and tagging.

  3. Revealing Partons in Hadrons: From the ISR to the SPS Collider

    NASA Astrophysics Data System (ADS)

    Darriulat, Pierre; di Lella, Luigi

    2015-07-01

    Our understanding of the structure of hadrons has developed during the seventies and early eighties from a few vague ideas to a precise theory, Quantum Chromodynamics, that describes hadrons as made of elementary partons (quarks and gluons). Deep inelastic scattering of electrons and neutrinos on nucleons and electron-positron collisions have played a major role in this development. Less well known is the role played by hadron collisions in revealing the parton structure, studying the dynamic of interactions between partons and offering an exclusive laboratory for the direct study of gluon interactions. The present article recalls the decisive contributions made by the CERN Intersecting Storage Rings and, later, the proton-antiproton SPS Collider to this chapter of physics.

  4. A uniform method for analytically modeling mulit-target acquisition with independent networked imaging sensors

    NASA Astrophysics Data System (ADS)

    Friedman, Melvin

    2014-05-01

    The problem solved in this paper is easily stated: for a scenario with 𝑛 networked and moving imaging sensors, 𝑚 moving targets and 𝑘 independent observers searching imagery produced by the 𝑛 moving sensors, analytically model system target acquisition probability for each target as a function of time. Information input into the model is the time dependence of 𝘗∞ and 𝜏, two parameters that describe observer-sensor-atmosphere-range-target properties of the target acquisition system for the case where neither the sensor nor target is moving. The parameter 𝘗∞ can be calculated by the NV-IPM model and 𝜏 is estimated empirically from 𝘗∞. In this model 𝑛, 𝑚 and 𝑘 are integers and 𝑘 can be less than, equal to or greater than 𝑛. Increasing 𝑛 and 𝑘 results in a substantial increase in target acquisition probabilities. Because the sensors are networked, a target is said to be detected the moment the first of the 𝑘 observers declares the target. The model applies to time-limited or time-unlimited search, and applies to any imaging sensors operating in any wavelength band provided each sensor can be described by 𝘗∞ and 𝜏 parameters.

  5. Manipulating MicroRNAs in Murine Models: Targeting the Multi-Targeting in Epilepsy

    PubMed Central

    2017-01-01

    MicroRNAs are small noncoding RNAs that work posttranscriptionally to negatively regulate protein levels. They influence neuronal and glial structure and function, neuroinflammatory signaling, cell death, neurogenesis, and other processes relevant to epileptogenesis. Functional studies using oligonucleotide inhibitors (antagomirs) and mimics (agomirs) to modulate microRNAs in rat and mouse models of epilepsy show effects on evoked and spontaneous seizures and attendant neuropathology. The present review summarizes recent findings and points to gaps in our knowledge of the underlying mechanisms and directions for the future. PMID:28331471

  6. Passive radar tracking of a maneuvering target using variable structure multiple-model algorithm

    NASA Astrophysics Data System (ADS)

    Mao, Yunxiang; Zhou, Xiaohui; Zhang, Jin

    2013-03-01

    The variable structure multiple-model (VSMM) algorithm to passive radar maneuvering target tracking problem is considered. A new VSMM design, expected mode augmentation based on likely model set (LMS-EMA) algorithm is presented. The LMS-EMA algorithm adaptively determines the fixed grid model set using likely model set (LMS) algorithm, and generates the expected mode based on this set. Then, the union of fixed grid model set and expected model is used to perform multiple-model estimation. The performance of the LMS-EMA algorithm is evaluated via simulation of a highly maneuvering target tracking problem.

  7. Correlated UV Through IR Signature Modeling of Targets and Backgrounds

    DTIC Science & Technology

    1998-11-01

    other high energy sources. In particular, variation of the sources as a function of time, wavelength and aspect angle is discussed, as these variations...sources as a function of time, wavelength and aspect angle is discussed, as these variations may be critical to the discrimination of targets...δt, a, v) = S f (λ, δλ)J (t)A(θ, φ)P(a)V (v)ψ (1) where A(θ, φ) is an aspect angle function that defines the relative magnitude of the source viewed

  8. Medium-induced gluon radiation in hard forward parton scattering in the saturation formalism

    NASA Astrophysics Data System (ADS)

    Munier, Stéphane; Peigné, Stéphane; Petreska, Elena

    2017-01-01

    We derive the medium-induced, fully coherent soft gluon radiation spectrum associated with the hard forward scattering of an energetic parton off a nucleus, in the saturation formalism within the Gaussian approximation for the relevant correlators of Wilson lines and for finite number of colors. The validity range of the result is rigorously specified by keeping track of the order of magnitude of subleading contributions to the spectrum. The connection between the saturation formalism and the opacity expansion used in previous studies of the same observable is made apparent. Our calculation sets the basis for further studies of the interplay between saturation and fully coherent energy loss in hard forward parton scattering.

  9. Studies of Parton Propagation and Hadron Formation in the Space-Time Domain

    SciTech Connect

    Brooks, Will; Hakobyan, Hayk

    2008-10-13

    Over the past decade, new data from HERMES, Jefferson Lab, Fermilab, and RHIC that connect to parton propagation and hadron formation have become available. Semi-inclusive DIS on nuclei, the Drell-Yan reaction, and heavy-ion collisions all bring different kinds of information on parton propagation within a medium, while the most direct information on hadron formation comes from the DIS data. Over the next decade one can hope to begin to understand these data within a unified picture. We briefly survey the most relevant data and the common elements of the physics picture, then highlight the new Jefferson Lab data, and close with a prospective for the future.

  10. An O({alpha}{sub s}) Monte Carlo for W production with parton showering

    SciTech Connect

    Baer, H.A.

    1991-12-31

    We construct an event generator for p{bar p}{yields}W{sup +}X{yields}e{sup +}{nu}X including complete O({alpha}{sub s}) corrections, and interface with initial and final state parton showers. Problems with negative weights and with double counting higher order parton radiation are averted. We present results for W+n-jet production, and compare with results from complete tree-level calculations, and shower calculations off of the lowest order 2{yields}2 sub-process. We also compute the {sub qT}(W) distribution, and compare with data.

  11. An O([alpha][sub s]) Monte Carlo for W production with parton showering

    SciTech Connect

    Baer, H.A.

    1991-01-01

    We construct an event generator for p[bar p][yields]W[sup +]X[yields]e[sup +][nu]X including complete O([alpha][sub s]) corrections, and interface with initial and final state parton showers. Problems with negative weights and with double counting higher order parton radiation are averted. We present results for W+n-jet production, and compare with results from complete tree-level calculations, and shower calculations off of the lowest order 2[yields]2 sub-process. We also compute the [sub qT](W) distribution, and compare with data.

  12. nCTEQ15 - Global analysis of nuclear parton distributions with uncertainties

    SciTech Connect

    Kusina, A.; Jezo, T.; Clark, D. B.; Keppel, Cynthia; Lyonnet, F.; Morfin, Jorge; Olness, F. I.; Owens, Jeff; Schienbein, I.

    2015-09-01

    We present the first official release of the nCTEQ nuclear parton distribution functions with errors. The main addition to the previous nCTEQ PDFs is the introduction of PDF uncertainties based on the Hessian method. Another important addition is the inclusion of pion production data from RHIC that give us a handle on constraining the gluon PDF. This contribution summarizes our results from arXiv:1509.00792 and concentrates on the comparison with other groups providing nuclear parton distributions.

  13. Neuromorphic Modeling of Moving Target Detection in Insects

    DTIC Science & Technology

    2007-12-31

    modeling - the implementation of STMD or related models in analog VLSI circuitry - was specified as an activity in the project proposal, but was de...lAmplifying Neural Behavior (Shoemaker) NMDA receptors are a class of metabotropic or second-messenger synaptic receptors that are typically activated...an analog VLSI model were to be fabricated). Below in Figure 6 are shown the results for a one-dimensional predictor network in response to data taken

  14. Adaptive target detection in foliage-penetrating SAR images using alpha-stable models.

    PubMed

    Banerjee, A; Burlina, P; Chellappa, R

    1999-01-01

    Detecting targets occluded by foliage in foliage-penetrating (FOPEN) ultra-wideband synthetic aperture radar (UWB SAR) images is an important and challenging problem. Given the different nature of target returns in foliage and nonfoliage regions and very low signal-to-clutter ratio in UWB imagery, conventional detection algorithms fail to yield robust target detection results. A new target detection algorithm is proposed that (1) incorporates symmetric alpha-stable (SalphaS) distributions for accurate clutter modeling, (2) constructs a two-dimensional (2-D) site model for deriving local context, and (3) exploits the site model for region-adaptive target detection. Theoretical and empirical evidence is given to support the use of the SalphaS model for image segmentation and constant false alarm rate (CFAR) detection. Results of our algorithm on real FOPEN images collected by the Army Research Laboratory are provided.

  15. A chest-shape target automatic detection method based on Deformable Part Models

    NASA Astrophysics Data System (ADS)

    Zhang, Mo; Jin, Weiqi; Li, Li

    2016-10-01

    Automatic weapon platform is one of the important research directions at domestic and overseas, it needs to accomplish fast searching for the object to be shot under complex background. Therefore, fast detection for given target is the foundation of further task. Considering that chest-shape target is common target of shoot practice, this paper treats chestshape target as the target and studies target automatic detection method based on Deformable Part Models. The algorithm computes Histograms of Oriented Gradient(HOG) features of the target and trains a model using Latent variable Support Vector Machine(SVM); In this model, target image is divided into several parts then we can obtain foot filter and part filters; Finally, the algorithm detects the target at the HOG features pyramid with method of sliding window. The running time of extracting HOG pyramid with lookup table can be shorten by 36%. The result indicates that this algorithm can detect the chest-shape target in natural environments indoors or outdoors. The true positive rate of detection reaches 76% with many hard samples, and the false positive rate approaches 0. Running on a PC (Intel(R)Core(TM) i5-4200H CPU) with C++ language, the detection time of images with the resolution of 640 × 480 is 2.093s. According to TI company run library about image pyramid and convolution for DM642 and other hardware, our detection algorithm is expected to be implemented on hardware platform, and it has application prospect in actual system.

  16. Coupled Particulate and Continuum Model for Nanoparticle Targeted Delivery

    PubMed Central

    Tan, Jifu; Wang, Shunqiang; Yang, Jie; Liu, Yaling

    2013-01-01

    Prediction of nanoparticle (NP) distribution in a vasculature involves transport phenomena at various scales and is crucial for the evaluation of NP delivery efficiency. A combined particulate and continuum model is developed to model NP transport and delivery processes. In the particulate model ligand-receptor binding kinetics is coupled with Brownian dynamics to study NP binding on a microscale. An analytical formula is derived to link molecular level binding parameters to particulate level adhesion and detachment rates. The obtained NP adhesion rates are then coupled with a convection-diffusion-reaction model to study NP transport and delivery at macroscale. The binding results of the continuum model agree well with those from the particulate model. The effects of shear rate, particle size and vascular geometry on NP adhesion are investigated. Attachment rates predicted by the analytical formula also agree reasonably well with the experimental data reported in literature. The developed coupled model that links ligand-receptor binding dynamics to NP adhesion rate along with macroscale transport and delivery processes may serve as a faster evaluation and prediction tool to determine NP distribution in complex vascular networks. PMID:23729869

  17. Fuzzy Neural Network-Based Interacting Multiple Model for Multi-Node Target Tracking Algorithm

    PubMed Central

    Sun, Baoliang; Jiang, Chunlan; Li, Ming

    2016-01-01

    An interacting multiple model for multi-node target tracking algorithm was proposed based on a fuzzy neural network (FNN) to solve the multi-node target tracking problem of wireless sensor networks (WSNs). Measured error variance was adaptively adjusted during the multiple model interacting output stage using the difference between the theoretical and estimated values of the measured error covariance matrix. The FNN fusion system was established during multi-node fusion to integrate with the target state estimated data from different nodes and consequently obtain network target state estimation. The feasibility of the algorithm was verified based on a network of nine detection nodes. Experimental results indicated that the proposed algorithm could trace the maneuvering target effectively under sensor failure and unknown system measurement errors. The proposed algorithm exhibited great practicability in the multi-node target tracking of WSNs. PMID:27809271

  18. CAD Model and Visual Assisted Control System for NIF Target Area Positioners

    SciTech Connect

    Tekle, E A; Wilson, E F; Paik, T S

    2007-10-03

    The National Ignition Facility (NIF) target chamber contains precision motion control systems that reach up to 6 meters into the target chamber for handling targets and diagnostics. Systems include the target positioner, an alignment sensor, and diagnostic manipulators (collectively called positioners). Target chamber shot experiments require a variety of positioner arrangements near the chamber center to be aligned to an accuracy of 10 micrometers. Positioners are some of the largest devices in NIF, and they require careful monitoring and control in 3 dimensions to prevent interferences. The Integrated Computer Control System provides efficient and flexible multi-positioner controls. This is accomplished through advanced video-control integration incorporating remote position sensing and realtime analysis of a CAD model of target chamber devices. The control system design, the method used to integrate existing mechanical CAD models, and the offline test laboratory used to verify proper operation of the control system are described.

  19. Hydrodynamic modeling of laser interaction with micro-structured targets

    SciTech Connect

    Velechovsky, Jan; Limpouch, Jiri; Liska, Richard; Tikhonchuk, Vladimir

    2016-08-03

    A model is developed for numerical simulations of laser absorption in plasmas made of porous materials, with particular interest in low-density foams. Laser absorption is treated on two spatial scales simultaneously. At the microscale, the expansion of a thin solid pore wall is modeled in one dimension and the information obtained is used in the macroscale fluid simulations for the description of the plasma homogenization behind the ionization front. This two-scale laser absorption model is implemented in the arbitrary Lagrangian–Eulerian hydrocode PALE. In conclusion, the numerical simulations of laser penetration into low-density foams compare favorably with published experimental data.

  20. Dynamic Target Acquisition: Empirical Models of Operator Performance.

    DTIC Science & Technology

    1980-08-01

    tarjet to )e centered. At the beginning of those trials with ,i t.trqet present, ,t woiild I nywhere withln the center two-thirds (if the d%,,1 y. MD...Target Tpe Tank Half-Track Truck Low 0.206 0.169 0.191 Medium 0.252 0.205 0.226 High 0.253 o.I l 0.211 Speed FT_SEC. x_ Tarjet 7 ype Tank Half-Track Truck...1 25915 27212 I Scene Complexity Tarjet Type ORDERED MEANS 22521 23190 27743 NS 22521 * 23190 * 27743 I I I I I I I I *p •.05 1723 AOCDOPWOVELL

  1. Inorganic Nanovehicle Targets Tumor in an Orthotopic Breast Cancer Model

    NASA Astrophysics Data System (ADS)

    Choi, Goeun; Kwon, Oh-Joon; Oh, Yeonji; Yun, Chae-Ok; Choy, Jin-Ho

    2014-03-01

    The clinical efficacy of conventional chemotherapeutic agent, methotrexate (MTX), can be limited by its very short plasma half-life, the drug resistance, and the high dosage required for cancer cell suppression. In this study, a new drug delivery system is proposed to overcome such limitations. To realize such a system, MTX was intercalated into layered double hydroxides (LDHs), inorganic drug delivery vehicle, through a co-precipitation route to produce a MTX-LDH nanohybrid with an average particle size of approximately 130 nm. Biodistribution studies in mice bearing orthotopic human breast tumors revealed that the tumor-to-liver ratio of MTX in the MTX-LDH-treated-group was 6-fold higher than that of MTX-treated-one after drug treatment for 2 hr. Moreover, MTX-LDH exhibited superior targeting effect resulting in high antitumor efficacy inducing a 74.3% reduction in tumor volume compared to MTX alone, and as a consequence, significant survival benefits. Annexin-V and propidium iodine dual staining and TUNEL analysis showed that MTX-LDH induced a greater degree of apoptosis than free MTX. Taken together, our data demonstrate that a new MTX-LDH nanohybrid exhibits a superior efficacy profile and improved distribution compared to MTX alone and has the potential to enhance therapeutic efficacy via inhibition of tumor proliferation and induction of apoptosis.

  2. Drell-Yan production at NNLL'+NNLO matched to parton showers

    NASA Astrophysics Data System (ADS)

    Alioli, Simone; Bauer, Christian W.; Berggren, Calvin; Tackmann, Frank J.; Walsh, Jonathan R.

    2015-11-01

    We present results for Drell-Yan production from the geneva Monte-Carlo framework. We combine the fully differential next-to-next-to leading order (NNLO) calculation with higher-order resummation in the 0-jettiness resolution variable. The resulting parton-level events are further combined with parton showering and hadronization provided by pythia8. The 0-jettiness resummation is carried out to NNLL' , which consistently incorporates all singular virtual and real NNLO corrections. It thus provides a natural perturbative connection between the NNLO calculation and the parton shower regime, including a systematic assessment of perturbative uncertainties. In this way, inclusive observables are correct to NNLO, up to small power corrections in the resolution cutoff. Furthermore, the perturbative accuracy of zero-jet-like resummation variables is significantly improved beyond the parton shower approximation. We provide comparisons with LHC measurements of Drell-Yan production at 7 TeV from ATLAS, CMS, and LHCb. As already observed in e+e- collisions, for resummation-sensitive observables, the agreement with data is noticeably improved by using a lower value of αs(MZ)=0.1135 .

  3. Global extraction of the parton-to-pion fragmentation functions at NLO accuracy in QCD

    NASA Astrophysics Data System (ADS)

    Hernández-Pinto, R. J.; Epele, M.; de Florian, D.; Sassot, R.; Stratmann, M.

    2016-10-01

    In this review, we discuss the results on the parton-to-pion fragmentation functions obtained in a combined NLO fit to data of single-inclusive hadron production in electron-positron annihilation, proton-proton collisions, and lepton-nucleon deep-inelastic scattering. A more complete discussion can be found in Ref. [1].

  4. Drell-Yan Lepton pair production at NNLO QCD with parton showers

    DOE PAGES

    Hoeche, Stefan; Li, Ye; Prestel, Stefan

    2015-04-13

    We present a simple approach to combine NNLO QCD calculations and parton showers, based on the UNLOPS technique. We apply the method to the computation of Drell-Yan lepton-pair production at the Large Hadron Collider. We comment on possible improvements and intrinsic uncertainties.

  5. Making Sense in the City: Dolly Parton, Early Reading and Educational Policy-Making

    ERIC Educational Resources Information Center

    Hall, Christine; Jones, Susan

    2016-01-01

    In this paper, we present a case study of a philanthropic literacy initiative, Dolly Parton's Imagination Library, a book-gifting scheme for under 5s, and consider the impact of the scheme on literacy policy in the English city where it was introduced. We bring four lenses to bear on the case study. First, we analyse the operation of the scheme in…

  6. Effects produced by multi-parton interactions and color reconnection in small systems

    NASA Astrophysics Data System (ADS)

    Cuautle, Eleazar; Ortiz, Antonio; Paić, Guy

    2016-12-01

    Multi-parton interactions and color reconnection can produce QGP-like effects in small systems, specifically, radial flow-like patterns. For pp collisions simulated with Pythia 8.212, in this work we investigate their effects on different observables like event multiplicity, event shapes and transverse momentum distributions.

  7. Generalized Parton Distributions and Deep Exclusive Reactions: Present Program at Jlab

    SciTech Connect

    Michel Garcon

    2004-07-01

    We review briefly the physical concept of generalized parton distributions and the experimental challenges associated with the corresponding measurements of deep exclusive reactions. The first data obtained at Jefferson Lab for exclusive photon (DVCS) and vector meson (DVMP) electroproduction above the resonance-excitation region are described. Two upcoming dedicated DVCS experiments are presented in some detail.

  8. Impact modeling and prediction of attacks on cyber targets

    NASA Astrophysics Data System (ADS)

    Khalili, Aram; Michalk, Brian; Alford, Lee; Henney, Chris; Gilbert, Logan

    2010-04-01

    In most organizations, IT (information technology) infrastructure exists to support the organization's mission. The threat of cyber attacks poses risks to this mission. Current network security research focuses on the threat of cyber attacks to the organization's IT infrastructure; however, the risks to the overall mission are rarely analyzed or formalized. This connection of IT infrastructure to the organization's mission is often neglected or carried out ad-hoc. Our work bridges this gap and introduces analyses and formalisms to help organizations understand the mission risks they face from cyber attacks. Modeling an organization's mission vulnerability to cyber attacks requires a description of the IT infrastructure (network model), the organization mission (business model), and how the mission relies on IT resources (correlation model). With this information, proper analysis can show which cyber resources are of tactical importance in a cyber attack, i.e., controlling them enables a large range of cyber attacks. Such analysis also reveals which IT resources contribute most to the organization's mission, i.e., lack of control over them gravely affects the mission. These results can then be used to formulate IT security strategies and explore their trade-offs, which leads to better incident response. This paper presents our methodology for encoding IT infrastructure, organization mission and correlations, our analysis framework, as well as initial experimental results and conclusions.

  9. VNI version 4.1. Simulation of high-energy particle collisions in QCD: Space-time evolution of e{sup +}e{sup {minus}}...A + B collisions with parton-cascades, cluster-hadronization, final-state hadron cascades

    SciTech Connect

    Geiger, K.; Longacre, R.; Srivastava, D.K.

    1999-02-01

    VNI is a general-purpose Monte-Carlo event-generator, which includes the simulation of lepton-lepton, lepton-hadron, lepton-nucleus, hadron-hadron, hadron-nucleus, and nucleus-nucleus collisions. It uses the real-time evolution of parton cascades in conjunction with a self-consistent hadronization scheme, as well as the development of hadron cascades after hadronization. The causal evolution from a specific initial state (determined by the colliding beam particles) is followed by the time-development of the phase-space densities of partons, pre-hadronic parton clusters, and final-state hadrons, in position-space, momentum-space and color-space. The parton-evolution is described in terms of a space-time generalization of the familiar momentum-space description of multiple (semi)hard interactions in QCD, involving 2 {r_arrow} 2 parton collisions, 2 {r_arrow} 1 parton fusion processes, and 1 {r_arrow} 2 radiation processes. The formation of color-singlet pre-hadronic clusters and their decays into hadrons, on the other hand, is treated by using a spatial criterion motivated by confinement and a non-perturbative model for hadronization. Finally, the cascading of produced prehadronic clusters and of hadrons includes a multitude of 2 {r_arrow} n processes, and is modeled in parallel to the parton cascade description. This paper gives a brief review of the physics underlying VNI, as well as a detailed description of the program itself. The latter program description emphasizes easy-to-use pragmatism and explains how to use the program (including simple examples), annotates input and control parameters, and discusses output data provided by it.

  10. Modelling Sensor and Target effects on LiDAR Waveforms

    NASA Astrophysics Data System (ADS)

    Rosette, J.; North, P. R.; Rubio, J.; Cook, B. D.; Suárez, J.

    2010-12-01

    The aim of this research is to explore the influence of sensor characteristics and interactions with vegetation and terrain properties on the estimation of vegetation parameters from LiDAR waveforms. This is carried out using waveform simulations produced by the FLIGHT radiative transfer model which is based on Monte Carlo simulation of photon transport (North, 1996; North et al., 2010). The opportunities for vegetation analysis that are offered by LiDAR modelling are also demonstrated by other authors e.g. Sun and Ranson, 2000; Ni-Meister et al., 2001. Simulations from the FLIGHT model were driven using reflectance and transmittance properties collected from the Howland Research Forest, Maine, USA in 2003 together with a tree list for a 200m x 150m area. This was generated using field measurements of location, species and diameter at breast height. Tree height and crown dimensions of individual trees were calculated using relationships established with a competition index determined for this site. Waveforms obtained by the Laser Vegetation Imaging Sensor (LVIS) were used as validation of simulations. This provided a base from which factors such as slope, laser incidence angle and pulse width could be varied. This has enabled the effect of instrument design and laser interactions with different surface characteristics to be tested. As such, waveform simulation is relevant for the development of future satellite LiDAR sensors, such as NASA’s forthcoming DESDynI mission (NASA, 2010), which aim to improve capabilities of vegetation parameter estimation. ACKNOWLEDGMENTS We would like to thank scientists at the Biospheric Sciences Branch of NASA Goddard Space Flight Center, in particular to Jon Ranson and Bryan Blair. This work forms part of research funded by the NASA DESDynI project and the UK Natural Environment Research Council (NE/F021437/1). REFERENCES NASA, 2010, DESDynI: Deformation, Ecosystem Structure and Dynamics of Ice. http

  11. Hypoxia in Models of Lung Cancer: Implications for Targeted Therapeutics

    PubMed Central

    Graves, Edward E.; Vilalta, Marta; Cecic, Ivana K.; Erler, Janine T.; Tran, Phuoc T.; Felsher, Dean; Sayles, Leanne; Sweet-Cordero, Alejandro; –Thu Le, Quynh; Giaccia, Amato J.

    2010-01-01

    Purpose In order to efficiently translate experimental methods from bench to bedside, it is imperative that laboratory models of cancer mimic human disease as closely as possible. In this study we sought to compare patterns of hypoxia in several standard and emerging mouse models of lung cancer in order to establish the appropriateness of each for evaluating the role of oxygen in lung cancer progression and therapeutic response. Experimental Design Subcutaneous and orthotopic human A549 lung carcinomas growing in nude mice as well as spontaneous K-ras or Myc-induced lung tumors grown in situ or subcutaneously were studied using fluorodeoxyglucose (FDG) and fluoroazomycin arabinoside (FAZA) positron emission tomography (PET), and post-mortem by immunohistochemical observation of the hypoxia marker pimonidazole. The response of these models to the hypoxia-activated cytotoxin PR-104 was also quantified by formation of γH2AX foci in vitro and in vivo. Finally, our findings were compared with oxygen electrode measurements of human lung cancers. Results Minimal FAZA and pimonidazole accumulation was seen in tumors growing within the lungs, while subcutaneous tumors showed substantial trapping of both hypoxia probes. These observations correlated with the response of these tumors to PR-104, and with the reduced incidence of hypoxia in human lung cancers relative to other solid tumor types. Conclusions These findings suggest that in situ models of lung cancer in mice may be more reflective of the human disease, and encourage judicious selection of preclinical tumor models for the study of hypoxia imaging and anti-hypoxic cell therapies. PMID:20858837

  12. Algorithm research on infrared imaging target extraction based on GAC model

    NASA Astrophysics Data System (ADS)

    Li, Yingchun; Fan, Youchen; Wang, Yanqing

    2016-10-01

    Good target detection and tracking technique is significantly meaningful to increase infrared target detection distance and enhance resolution capacity. For the target detection problem about infrared imagining, firstly, the basic principles of level set method and GAC model are is analyzed in great detail. Secondly, "convergent force" is added according to the defect that GAC model is stagnant outside the deep concave region and cannot reach deep concave edge to build the promoted GAC model. Lastly, the self-adaptive detection method in combination of Sobel operation and GAC model is put forward by combining the advantages that subject position of the target could be detected with Sobel operator and the continuous edge of the target could be obtained through GAC model. In order to verify the effectiveness of the model, the two groups of experiments are carried out by selecting the images under different noise effects. Besides, the comparative analysis is conducted with LBF and LIF models. The experimental result shows that target could be better locked through LIF and LBF algorithms for the slight noise effect. The accuracy of segmentation is above 0.8. However, as for the strong noise effect, the target and noise couldn't be distinguished under the strong interference of GAC, LIF and LBF algorithms, thus lots of non-target parts are extracted during iterative process. The accuracy of segmentation is below 0.8. The accurate target position is extracted through the algorithm proposed in this paper. Besides, the accuracy of segmentation is above 0.8.

  13. Target Mass Corrections Revisited

    SciTech Connect

    W. Melnitchouk; F. Steffens

    2006-03-07

    We propose a new implementation of target mass corrections to nucleon structure functions which, unlike existing treatments, has the correct kinematic threshold behavior at finite Q{sup 2} in the x {yields} 1 limit. We illustrate the differences between the new approach and existing prescriptions by considering specific examples for the F{sub 2} and F{sub L} structure functions, and discuss the broader implications of our results, which call into question the notion of universal parton distribution at finite Q{sup 2}.

  14. [Molecular model of anthrax toxin translocation into target-cells].

    PubMed

    Noskov, A N

    2014-01-01

    Anthrax toxin is formed from three components: protective antigen (PA), lethal (LF) and edema (EF) factors. PA83 is cleaved by cell surface protease furin to produce a 63-kDa fragment (PA63). PA63 and LF/EF molecules are assembled to anthrax toxin complexes: oligomer PA63 x 7 + LF/EF x 3. Assembly is occurred during of binding with cellular receptor or near surface of target-cell. This toxin complex forms pore and induces receptor-mediated endocytosis. Formed endosome consists extracellular liquid with LF/EF and membrane-associated ferments (H+ and K+/Na+-ATPases) and proteins (receptors and others). H+ concentration is increased into endosome as result of K/Na-ATPase-dependent- activity of H+-ATPase. Difference of potentials (between endosome and intracellular liquid) is increased and LF/EF molecules are moved to pore and bound with PA63-oligomer to PA63 x 7 + LF/EF x 7 and full block pore (ion-selective channel). Endosome is increased in volume and induces increasing of PA63-oligomer pore to.size of effector complex: LF/EF x 7 + PAl7 x 7 = 750 kDa. Effector complex is translocated from endosome to cytosol by means high difference of potentials (H+) and dissociates from PA47 x 7 complex after cleavage of FFD315-sait by intracellular chymotrypsin-like proteases in all 7 molecules PA63. PA47 x 7 complex (strongly fixed in membrane with debris of hydrophobic loops) return into endosome and pore is destroyed. Endosome pH is decreased rapidly and PA47 x 7 complex is destroyed by endosomal/lysosomal proteases. Receptor-mediated endocytosis is ended by endosome recycling in cell-membrane.

  15. Healthy latrine development model to achieve MDGs target

    NASA Astrophysics Data System (ADS)

    Soedjono, Eddy S.; Arumsari, Nurvita

    2014-03-01

    A case happened in Pungging sub-district was one example of low level healthy habits of East Java inhabitants. According to the data of Mojokerto district Health Service until the end of 2010, there are 219 families (or about 8% of total families in Pungging sub-district) which do not have their own latrine. Moreover, if we observe closely to their prosperity level, the percentage of disadvantaged families and prosperous level I is still adequately high about 29,54% of the total number of families in Pungging sub-district. Accordingly, comprehensive studies related to basic sanitation requirement need to be done, not only in the matter of quantity but also in the matter of quality. Furthermore, further studies on people's knowledge and understanding on healthy sanitation also needed in the effort to understand people's demand to own latrine (willingness to pay) and ability to pay. Consequently, the design of healthy latrine which agrees with people's demand and ability is needed in order to achieve the target of Open Defecation Free (ODF) in 2015. The research methodology includes literary study, data collection, data analysis, and healthy latrine design. Out of 75 respondents, only 32% of them who attended counselling program on healthy latrine and only 48% of them who have knowledge on healthy latrine, but in reality 96% of respondents stated that healthy latrine is important. Healthy latrine, according to the respondents, is a place of defecation (BAB) which has components like latrine bowl or septic tank. Estimation on WTP distribution which is divided in two categories; low category with range of willingness to pay from IDR 0 to IDR 200,000 is IDR 90,048,000. On the other hand, high category with range of willingness to pay more than IDR 1,000,000 is IDR 749,964,768. Estimation on respondents' ATP in the area of study on the sanitation maintenance service is from IDR 7,000 to IDR 30,000.

  16. [Targeted molecular therapy based on advanced cancer stem cell model].

    PubMed

    Hirao, Atsushi

    2015-08-01

    Improvement of cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TICs). Although it was hypothesized that tumors are organized as hierarchies of tumor cells that are sustained by rare TICs, like normal tissue stem cells, there are several controversies towards such cancer stem cell model, e.g. reversible change of stem cell like population based on epigenetic changes, clonal genetic evolution and problems in xenotransplantation system. Despite complexity in cancer stem cell models, studies in cancer stem cell field have revealed that there are close relationship between cancer malignancy and stem cell properties, called "stemness". Understanding molecular mechanisms for controlling stemness would contribute to establishment of novel diagnostics or therapeutics for cancer.

  17. Probabilistic Model of a Floating Target Behaviour in Rough Seas

    DTIC Science & Technology

    2013-07-01

    Honolulu, Hawaii, 1976, pp. 301-329. 10. Pierson, W. J., and Moskowitz, L . A proposed spectral form for fully developed wind seas based on the...175-181. 14. Torsethaugen, K. Simplified double peak spectral model for ocean waves. SINTEF Report STF80 A048052, SINTEF Fisheries and Aquaculture ...RELEASE USE ( L ) NEXT TO DOCUMENT CLASSIFICATION) Document (U) Title (U) Abstract (U) 4. AUTHOR(S) Rada Pushkarova 5

  18. A Model of False Alarms in Target Acquisition by Human Observers.

    DTIC Science & Technology

    1995-09-01

    alarms are expected on the average? 2. A descriptive model of the observer ensemble . How can variations among observers be quantified? This work...correlations do not persist for observers in a different test, who were conditioned to expect fewer targets. Observer state turns out to be a much...model is valid only for the specific high-target-density scenario of the Phase 1 test. It does not consider variation in the observer state . Until

  19. A Mathematical Model for Calculating Non-Detection Probability of a Random Tour Target.

    DTIC Science & Technology

    1985-12-01

    model avoiding detection (i.e., surviving) to some specified time, t. This model assumes that there is a stationary searcher having a " cookie -cutter...a stationary searcher having a * cookie -cutter* sensor located in the center of the search area. A Monte-Carlo simulation/program was used to generate...thus has a " cookie -cutter" sensor with detection range R. [Ref. 1] 2. The Target Starting Position The target’s starting position is uniformly

  20. A memory-based model for planning target reach postures in the presence of obstructions.

    PubMed

    Park, W; Singh, D; Martin, B J

    2006-12-15

    Existing posture prediction and motion simulation models generally lack the capability of simulating human obstruction avoidance during target reach. This compromises the utility of digital human models for ergonomics, as many design problems involve interactions between humans and obstructions. To address this problem, this paper presents a novel memory-based posture planning (MBPP) model, which plans reach postures that avoid obstructions. In this model, the task space is partitioned into small regions called cells. For a given human figure, each cell is linked to a memory that stores various alternative postures for reaching the cell. When a posture planning problem is given in terms of a target and an obstruction configuration, the model examines postures belonging to the relevant cell, selects collision-free ones and modifies them to exactly meet the hand target acquisition constraint. Simulation results showed that the MBPP model is capable of rapidly and robustly planning reach postures for various scenarios.

  1. Stability of Wilkinson's linear model of prism adaptation over time for various targets.

    PubMed

    Wallace, B

    1977-01-01

    Prism adaptation as measured by negative aftereffects (NA), proprioceptive shifts (PS), and visual shifts (VS) was assessed as a function of amount of exposure time and target specificity, whether an exposure and a test target background were the same or different, to determine the validity of Wilkinson's linear model (NA = PS + VS). With few exceptions the model was found to hold well up to 40 min of prism viewing regardless of type of exposure background. In addition target specificity affected magnitude of the NA component of adapation but not the PS and the VS components.

  2. Drug-target interaction prediction: databases, web servers and computational models.

    PubMed

    Chen, Xing; Yan, Chenggang Clarence; Zhang, Xiaotian; Zhang, Xu; Dai, Feng; Yin, Jian; Zhang, Yongdong

    2016-07-01

    Identification of drug-target interactions is an important process in drug discovery. Although high-throughput screening and other biological assays are becoming available, experimental methods for drug-target interaction identification remain to be extremely costly, time-consuming and challenging even nowadays. Therefore, various computational models have been developed to predict potential drug-target associations on a large scale. In this review, databases and web servers involved in drug-target identification and drug discovery are summarized. In addition, we mainly introduced some state-of-the-art computational models for drug-target interactions prediction, including network-based method, machine learning-based method and so on. Specially, for the machine learning-based method, much attention was paid to supervised and semi-supervised models, which have essential difference in the adoption of negative samples. Although significant improvements for drug-target interaction prediction have been obtained by many effective computational models, both network-based and machine learning-based methods have their disadvantages, respectively. Furthermore, we discuss the future directions of the network-based drug discovery and network approach for personalized drug discovery based on personalized medicine, genome sequencing, tumor clone-based network and cancer hallmark-based network. Finally, we discussed the new evaluation validation framework and the formulation of drug-target interactions prediction problem by more realistic regression formulation based on quantitative bioactivity data.

  3. Knowledge-based approach for generating target system specifications from a domain model

    NASA Technical Reports Server (NTRS)

    Gomaa, Hassan; Kerschberg, Larry; Sugumaran, Vijayan

    1992-01-01

    Several institutions in industry and academia are pursuing research efforts in domain modeling to address unresolved issues in software reuse. To demonstrate the concepts of domain modeling and software reuse, a prototype software engineering environment is being developed at George Mason University to support the creation of domain models and the generation of target system specifications. This prototype environment, which is application domain independent, consists of an integrated set of commercial off-the-shelf software tools and custom-developed software tools. This paper describes the knowledge-based tool that was developed as part of the environment to generate target system specifications from a domain model.

  4. Model emulates human smooth pursuit system producing zero-latency target tracking.

    PubMed

    Bahill, A T; McDonald, J D

    1983-01-01

    Humans can overcome the 150 ms time delay of the smooth pursuit eye movement system and track smoothly moving visual targets with zero-latency. Our target-selective adaptive control model can also overcome an inherent time delay and produce zero-latency tracking. No other model or man-made system can do this. Our model is physically realizable and physiologically realistic. The technique used in our model should be useful for analyzing other time-delay systems, such as man-machine systems and robots.

  5. Designing and modeling a centrifugal microfluidic device to separate target blood cells

    NASA Astrophysics Data System (ADS)

    Shamloo, Amir; Selahi, AmirAli; Madadelahi, Masoud

    2016-03-01

    The objective of this study is to design a novel and efficient portable lab-on-a-CD (LOCD) microfluidic device for separation of specific cells (target cells) using magnetic beads. In this study the results are shown for neutrophils as target cells. However, other kinds of target cells can be separated in a similar approach. The designed microfluidics can be utilized as a point of care system for neutrophil detection. This microfluidic system employs centrifugal and magnetic forces for separation. After model validation by the experimental data in the literature (that may be used as a design tool for developing centrifugo-magnetophoretic devices), two models are presented for separation of target cells using magnetic beads. The first model consists of one container in the inlet section and two containers in the outlets. Initially, the inlet container is filled with diluted blood sample which is a mixture of red blood cells (RBCs) plus neutrophils which are attached to Magnetic beads. It is shown that by using centrifugal and magnetic forces, this model can separate all neutrophils with recovery factor of ~100%. In the second model, due to excess of magnetic beads in usual experimental analysis (to ensure that all target cells are attached to them) the geometry is improved by adding a third outlet for these free magnetic beads. It is shown that at angular velocity of 45 rad s-1, recovery factor of 100% is achievable for RBCs, free magnetic beads and neutrophils as target cells.

  6. Ballistic protons in incoherent exclusive vector meson production as a measure of rare parton fluctuations at an electron-ion collider.

    PubMed

    Lappi, T; Mäntysaari, H; Venugopalan, R

    2015-02-27

    We argue that the proton multiplicities measured in Roman pot detectors at an electron ion collider can be used to determine centrality classes in incoherent diffractive scattering. Incoherent diffraction probes the fluctuations in the interaction strengths of multiparton Fock states in the nuclear wave functions. In particular, the saturation scale that characterizes this multiparton dynamics is significantly larger in central events relative to minimum bias events. As an application, we study the centrality dependence of incoherent diffractive vector meson production. We identify an observable which is simultaneously very sensitive to centrality triggered parton fluctuations and insensitive to details of the model.

  7. A model for the detection of moving targets in visual clutter inspired by insect physiology.

    PubMed

    Wiederman, Steven D; Shoemaker, Patrick A; O'Carroll, David C

    2008-07-30

    We present a computational model for target discrimination based on intracellular recordings from neurons in the fly visual system. Determining how insects detect and track small moving features, often against cluttered moving backgrounds, is an intriguing challenge, both from a physiological and a computational perspective. Previous research has characterized higher-order neurons within the fly brain, known as 'small target motion detectors' (STMD), that respond robustly to moving features, even when the velocity of the target is matched to the background (i.e. with no relative motion cues). We recorded from intermediate-order neurons in the fly visual system that are well suited as a component along the target detection pathway. This full-wave rectifying, transient cell (RTC) reveals independent adaptation to luminance changes of opposite signs (suggesting separate ON and OFF channels) and fast adaptive temporal mechanisms, similar to other cell types previously described. From this physiological data we have created a numerical model for target discrimination. This model includes nonlinear filtering based on the fly optics, the photoreceptors, the 1(st) order interneurons (Large Monopolar Cells), and the newly derived parameters for the RTC. We show that our RTC-based target detection model is well matched to properties described for the STMDs, such as contrast sensitivity, height tuning and velocity tuning. The model output shows that the spatiotemporal profile of small targets is sufficiently rare within natural scene imagery to allow our highly nonlinear 'matched filter' to successfully detect most targets from the background. Importantly, this model can explain this type of feature discrimination without the need for relative motion cues.

  8. Computational Modeling and Neuroimaging Techniques for Targeting during Deep Brain Stimulation

    PubMed Central

    Sweet, Jennifer A.; Pace, Jonathan; Girgis, Fady; Miller, Jonathan P.

    2016-01-01

    Accurate surgical localization of the varied targets for deep brain stimulation (DBS) is a process undergoing constant evolution, with increasingly sophisticated techniques to allow for highly precise targeting. However, despite the fastidious placement of electrodes into specific structures within the brain, there is increasing evidence to suggest that the clinical effects of DBS are likely due to the activation of widespread neuronal networks directly and indirectly influenced by the stimulation of a given target. Selective activation of these complex and inter-connected pathways may further improve the outcomes of currently treated diseases by targeting specific fiber tracts responsible for a particular symptom in a patient-specific manner. Moreover, the delivery of such focused stimulation may aid in the discovery of new targets for electrical stimulation to treat additional neurological, psychiatric, and even cognitive disorders. As such, advancements in surgical targeting, computational modeling, engineering designs, and neuroimaging techniques play a critical role in this process. This article reviews the progress of these applications, discussing the importance of target localization for DBS, and the role of computational modeling and novel neuroimaging in improving our understanding of the pathophysiology of diseases, and thus paving the way for improved selective target localization using DBS. PMID:27445709

  9. Development of a target-site based regional frequency model using historical information

    NASA Astrophysics Data System (ADS)

    Hamdi, Yasser; Bardet, Lise; Duluc, Claire-Marie; Rebour, Vincent

    2016-04-01

    Nuclear power facilities in France were designed to withstand extreme environmental conditions with a very low probability of failure. Nevertheless, some exceptional surges considered as outliers are not properly addressed by classical frequency analysis models. If available data at the site of interest (target-site) is sufficiently complete on a long period and not characterized by the presence of an outlier, at-site frequency analysis can be used to estimate quantiles with acceptable uncertainties. Otherwise, regional and historical information (HI) may be used to mitigate the lack of data and the influence of the outlier by increasing its representativeness in the sample. several models have been proposed over the last years for regional extreme surges frequency analysis in France to take into account these outliers in the frequency analysis. However, these models do not give a specific weight to the target site and cannot take into account HI. The objective of the present work is to develop a regional frequency model (RFM) centered on a target-site and using HI. The neighborhood between sites is measured by a degree of physical and statistical dependence between observations (with a prior confidence level). Unlike existing models, the obtained region around the target site (and constituting the neighboring sites) is sliding from a target-site to another. In other words, the developed model assigns a region for each target site. The idea behind the construction of a frequency model favoring target sites and the principle of moving regions around these target-sites is the original key point of the developed model. A related issue regards the estimation of missed and/or ungauged surges at target-sites from those of gauged potential neighboring sites, a multiple linear regression (MLR) is used and it can be extended to other reconstitutions models. MLR analysis can be considered conclusive only if available observations at neighboring sites are informative enough

  10. Pion transverse momentum dependent parton distributions in a light-front constituent approach, and the Boer-Mulders effect in the pion-induced Drell-Yan process

    NASA Astrophysics Data System (ADS)

    Pasquini, B.; Schweitzer, P.

    2014-07-01

    At leading twist the transverse momentum dependent parton distributions of the pion consist of two functions, the unpolarized f1,π(x,k⊥2) and the Boer-Mulders function h1,π⊥(x ,k⊥2). We study both functions within a light-front constituent model of the pion, comparing the results with different pion models and the corresponding nucleon distributions from a light-front constituent model. After evolution from the model scale to the relevant experimental scales, the results for the collinear pion valence parton distribution function f1,π(x) are in very good agreement with available parametrizations. Using the light-front constituent model results for the Boer-Mulders functions of the pion and nucleon, we calculate the coefficient ν in the angular distribution of Drell-Yan dileptons produced in pion-nucleus scattering, which is responsible for the violation of the Lam-Tung relation. We find a good agreement with the data, and carefully discuss the range of applicability of our approach.

  11. Modeling of remelting processes of metal targets using pulses of continuous laser with pre-impulses

    NASA Astrophysics Data System (ADS)

    Jach, Karol; Marczak, Jan; Świerczyński, Robert; Strzelec, Marek; Ostrowski, Roman; Sarzyński, Antoni; Skrzeczanowski, Wojciech; Rycyk, Antoni; CzyŻ, Krzysztof

    2016-12-01

    The study presents preliminary results of theoretical analyses concerning interaction of quasi-cw laser radiation with an aluminium target. The range of laser power the authors were interested in was from 1 to 10 kW, and target thicknesses from 0.1 to 1 cm. It was also assumed that a laser beam diameter on the target (Al) was around 0.5 cm. A mathematicalphysical model of the phenomenon was based on the equation of conservation of energy (spatially one-dimensional model - (z,t)) taking into account: radiation absorption and transport inside the target, heat conduction, reflection of part of radiation from the target's surface, and heat losses in the processes of melting and evaporation. Coefficients of light absorption and reflection from the target's surface were described with semi-empirical expressions, which took into account their dependence on the temperature and density. Initially, a case of target static during heating was considered. Subsequently, the problem of enhancement of radiation interaction with the target (decrease of reflection coefficient) by the use of short (< 20 ns), high power pre-impulse was analyzed. The last case needed expansion of a set of equations with the continuity equation and the equation of motion, to take into account evaporation of target's surface under influence of the pre-impulse. It was shown that thermal effect of the pre-impulse is practically not influencing final depths of target remelting. On the other hand, damage (matting) of the target's surface by the pre-impulse, causing the decrease of reflection coefficient can have a substantial influence on the remelting depth.

  12. The Target Model of Strategic Interaction of Kazan Federal University and the Region in the Field of Education

    ERIC Educational Resources Information Center

    Gabdulchakov, Valerian F.

    2016-01-01

    The subject of the study in the article is conceptual basis of construction of the target model of interaction between University and region. Hence the topic of the article "the Target model of strategic interaction between the University and the region in the field of education." The objective was to design a target model of this…

  13. Uncertainties in next-to-leading order plus parton shower matched simulations of inclusive jet and dijet production

    SciTech Connect

    Höche, Stefan; Schönherr, Marek

    2012-11-01

    We quantify uncertainties in the Monte Carlo simulation of inclusive and dijet final states, which arise from using the MC@NLO technique for matching next-to-leading order parton-level calculations and parton showers. We analyse a large variety of data from early measurements at the LHC. In regions of phase space where Sudakov logarithms dominate over high-energy effects, we observe that the main uncertainty can be ascribed to the free parameters of the parton shower. In complementary regions, the main uncertainty stems from the considerable freedom in the simulation of underlying events.

  14. Time-Domain Modeling of Electromagnetic Pulses Returned from Targets in Dispersive and Dissipative Media

    NASA Astrophysics Data System (ADS)

    Gaunaurd, G. C.; Strifors, H. C.; Sullivan, A.

    2008-06-01

    Using a Method-of-Moments (MoM) code, we earlier simulated ultra-wideband (UWB) returned echoes from two targets, one penetrable and one impenetrable, buried in a soil with known electric properties. The simple shape of mines, coupled with their predictable deployment in the ground, has also provided a fundamental understanding of the underlying backscatter phenomenology. In particular, the backscattered waveform from a mine can be decomposed into a collection of closely spaced copies of an elemental wave object with different amplitudes and time delays. This wave object is here defined as the derivative of the waveform incident on the target. The spacing of the copies or replicas of the wave object could be determined by the round trip time delay between scattering centers. This methodology was previously applied to impenetrable targets and is now applied also to a penetrable target. The previously computed returns from each target for a given incident pulse are modeled by a few copies of the elemental wave object with the time delay and amplitude of each copy taken as unknown parameters. These parameters are then determined by minimizing in the least square sense the difference between the MoM computed signal and the model signal using the differential evolution method (DEM). The methodology is extended by way of our previously developed target translated method (TTM) to approximate the computation of the backscattered model signal when the target is buried at a different depth in the soil with a different moisture content.

  15. Modeling of Oblique Penetration into Geologic Targets Using Cavity Expansion Penetrator Loading with Target free-Surface Effects

    SciTech Connect

    Jung, Joe; Longcope, Donald B.; Tabbara, Mazen R.

    1999-05-03

    A procedure has been developed to represent the loading on a penetrator and its motion during oblique penetration into geologic media. The penetrator is modeled with the explicit dynamics, finite element computer program PRONTO 3D and the coupled pressure on the penetrator is given in a new loading option based on a separate cavity expansion (CE) solution that accounts for the pressure-reduction from a nearby target free surface. The free-surface influ- ence distance is selected in a predictive manner by considering the pressure to expand a spherical cavity in a finite radius sphere of the target material. The CE/PRONTO 3D procedure allows a detailed description of the penetrator for predicting shock environments or structural failure dur- ing the entire penetration event and is sufficiently rapid to be used in design optimization. It has been evaluated by comparing its results with data from two field tests of a full-scale penetrator into frozen soil at an impact angles of 49.6 and 52.5 degrees from the horizontal. The measured penetrator rotations were 24 and 22 degrees, respectively. In the simulation, the rotation was21 degrees and predominately resulted from the pressure reduction of the free surface. Good agree- ment was also found for the penetration depth and axial and lateral acceleration at two locations in the penetrator.

  16. A physical model eye with 3D resolution test targets for optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Hu, Zhixiong; Liu, Wenli; Hong, Baoyu; Hao, Bingtao; Wang, Lele; Li, Jiao

    2014-09-01

    Optical coherence tomography (OCT) has been widely employed as non-invasive 3D imaging diagnostic instrument, particularly in the field of ophthalmology. Although OCT has been approved for use in clinic in USA, Europe and Asia, international standardization of this technology is still in progress. Validation of OCT imaging capabilities is considered extremely important to ensure its effective use in clinical diagnoses. Phantom with appropriate test targets can assist evaluate and calibrate imaging performance of OCT at both installation and throughout lifetime of the instrument. In this paper, we design and fabricate a physical model eye with 3D resolution test targets to characterize OCT imaging performance. The model eye was fabricated with transparent resin to simulate realistic ophthalmic testing environment, and most key optical elements including cornea, lens and vitreous body were realized. The test targets which mimic USAF 1951 test chart were fabricated on the fundus of the model eye by 3D printing technology. Differing from traditional two dimensional USAF 1951 test chart, a group of patterns which have different thickness in depth were fabricated. By measuring the 3D test targets, axial resolution as well as lateral resolution of an OCT system can be evaluated at the same time with this model eye. To investigate this specialized model eye, it was measured by a scientific spectral domain OCT instrument and a clinical OCT system respectively. The results demonstrate that the model eye with 3D resolution test targets have the potential of qualitatively and quantitatively validating the performance of OCT systems.

  17. 3D modelling of the electromagnetic response of geophysical targets using the FDTD method

    SciTech Connect

    Debroux, P.S.

    1996-05-01

    A publicly available and maintained electromagnetic finite-difference time domain (FDTD) code has been applied to the forward modelling of the response of 1D, 2D and 3D geophysical targets to a vertical magnetic dipole excitation. The FDTD method is used to analyze target responses in the 1 MHz to 100 MHz range, where either conduction or displacement currents may have the controlling role. The response of the geophysical target to the excitation is presented as changes in the magnetic field ellipticity. The results of the FDTD code compare favorably with previously published integral equation solutions of the response of 1D targets, and FDTD models calculated with different finite-difference cell sizes are compared to find the effect of model discretization on the solution. The discretization errors, calculated as absolute error in ellipticity, are presented for the different ground geometry models considered, and are, for the most part, below 10% of the integral equation solutions. Finally, the FDTD code is used to calculate the magnetic ellipticity response of a 2D survey and a 3D sounding of complicated geophysical targets. The response of these 2D and 3D targets are too complicated to be verified with integral equation solutions, but show the proper low- and high-frequency responses.

  18. Three-dimensional interferometric ISAR imaging for target scattering diagnosis and modeling.

    PubMed

    Xu, X; Narayanan, R M

    2001-01-01

    Two-dimensional (2-D) inverse synthetic aperture radar (ISAR) imaging has been widely used in target scattering diagnosis, modeling and target identification. A major shortcoming is that a 2-D ISAR image cannot provide information on the relative altitude of each scattering center on the target. In this paper, we present an interferometric inverse synthetic aperture radar (IF-ISAR) image processing technique for three-dimensional (3-D) target altitude image formation. The 2-D ISAR images are obtained from the signature data acquired as a function of frequency and azimuthal angle. A 3-D IF-ISAR altitude image can then be derived from two 2-D images reconstructed from the measurements by antennas at different altitudes. 3-D altitude image formation examples from both indoor and outdoor test range data are demonstrated on complex radar targets.

  19. Single and double spin asymmetries for deeply virtual Compton scattering measured with CLAS and a longitudinally polarized proton target

    SciTech Connect

    Pisano, S.; Biselli, A.; Niccolai, S.; Seder, E.; Guidal, M.; Mirazita, M.; Adhikari, K. P.; Adikaram, D.; Amaryan, M. J.; Anderson, M. D.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Bosted, P.; Briscoe, B.; Brock, J.; Brooks, W. K.; Burkert, V. D.; Carlin, C.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Cortes, O.; Crabb, D. G.; Crede, V.; D' Angelo, A.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fersch, R.; Filippi, A.; Fleming, J. A.; Fradi, A.; Garillon, B.; Garcon, M.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Gohn, W.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guo, L.; Hafidi, K.; Hanretty, C.; Hattawy, M.; Hicks, K.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Jenkins, D.; Jiang, X.; Jo, H. S.; Joo, K.; Joosten, S.; Keith, C. D.; Keller, D.; Kim, A.; Kim, W.; Klein, F. J.; Kubarovsky, V.; Kuhn, S. E.; Lenisa, P.; Livingston, K.; Lu, H. Y.; MacCormick, M.; MacGregor, Ian J. D.; Mayer, M.; McKinnon, B.; Meekins, D. G.; Meyer, C. A.; Mokeev, V.; Montgomery, R. A.; Moody, C. I.; Munoz Camacho, C.; Nadel-Turonski, P.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Phelps, W.; Phillips, J. J.; Pogorelko, O.; Price, J. W.; Procureur, S.; Prok, Y.; Puckett, A. J. R.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatie, F.; Salgado, C.; Schott, D.; Schumacher, R. A.; Skorodumina, I.; Smith, G. D.; Sober, D. I.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Stoler, P.; Strauch, S.; Sytnik, V.; Tian, Ye; Tkachenko, S.; Turisini, M.; Ungaro, M.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zana, L.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2015-03-19

    Single-beam, single-target, and double-spin asymmetries for hard exclusive photon production on the proton e→p→e'p'γ are presented. The data were taken at Jefferson Lab using the CLAS detector and a longitudinally polarized 14NH3 target. The three asymmetries were measured in 165 4-dimensional kinematic bins, covering the widest kinematic range ever explored simultaneously for beam and target-polarization observables in the valence quark region. The kinematic dependences of the obtained asymmetries are discussed and compared to the predictions of models of Generalized Parton Distributions. As a result, the measurement of three DVCS spin observables at the same kinematic points allows a quasi-model-independent extraction of the imaginary parts of the H and H~ Compton Form Factors, which give insight into the electric and axial charge distributions of valence quarks in the proton.

  20. Evaluating Three Programs Using a School Effectiveness Model: Direct Instruction, Target Teach, and Class Size Reduction

    ERIC Educational Resources Information Center

    Thompson, Bruce

    2006-01-01

    Value-added models, which rate schools for effectiveness while taking into account the poverty and other socioeconomic status of the students, are generating increased interest. This paper describes the use of one such model to evaluate whether school ratings changed when three new programs were introduced: the "Target Teach" curriculum…

  1. An empirical target discharging model for direct-drive implosions on OMEGA

    NASA Astrophysics Data System (ADS)

    Sinenian, N.; Manuel, M. J.-E.; Frenje, J. A.; Seguin, F. H.; Li, C. K.; Petrasso, R. D.; Goncharov, V.; Delettrez, J.; Stoeckl, C.; Sangster, T. C.; Cobble, J.

    2012-10-01

    Capsule charging of inertial confinement fusion (ICF) targets, observed previously on OMEGA, is detrimental to achieving the high areal densities (ρR) required for ignition and gain. This is because the target potential traps energetic electrons that can preheat the fuel, raise the adiabat and degrade compression. The decay-time of this potential is therefore an important parameter for preheat calculations. A non-linear model of the electrical discharging of ICF capsules has been developed. The empirical model, which captures the essential dynamics of the target voltage decay, incorporates previous charged-particle spectroscopic and radiographic measurements of the fields. It is shown that return currents through the target support fiber have a profound effect on the voltage-decay time. Implications of these findings for inertial fusion energy (IFE) are considered. This work was supported in part by DOE, LLE and LLNL.

  2. A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.

    PubMed

    Fakhar, Zeynab; Naiker, Suhashni; Alves, Claudio N; Govender, Thavendran; Maguire, Glenn E M; Lameira, Jeronimo; Lamichhane, Gyanu; Kruger, Hendrik G; Honarparvar, Bahareh

    2016-11-01

    An alarming rise of multidrug-resistant Mycobacterium tuberculosis strains and the continuous high global morbidity of tuberculosis have reinvigorated the need to identify novel targets to combat the disease. The enzymes that catalyze the biosynthesis of peptidoglycan in M. tuberculosis are essential and noteworthy therapeutic targets. In this study, the biochemical function and homology modeling of MurI, MurG, MraY, DapE, DapA, Alr, and Ddl enzymes of the CDC1551 M. tuberculosis strain involved in the biosynthesis of peptidoglycan cell wall are reported. Generation of the 3D structures was achieved with Modeller 9.13. To assess the structural quality of the obtained homology modeled targets, the models were validated using PROCHECK, PDBsum, QMEAN, and ERRAT scores. Molecular dynamics simulations were performed to calculate root mean square deviation (RMSD) and radius of gyration (Rg) of MurI and MurG target proteins and their corresponding templates. For further model validation, RMSD and Rg for selected targets/templates were investigated to compare the close proximity of their dynamic behavior in terms of protein stability and average distances. To identify the potential binding mode required for molecular docking, binding site information of all modeled targets was obtained using two prediction algorithms. A docking study was performed for MurI to determine the potential mode of interaction between the inhibitor and the active site residues. This study presents the first accounts of the 3D structural information for the selected M. tuberculosis targets involved in peptidoglycan biosynthesis.

  3. Multi-AUV Target Search Based on Bioinspired Neurodynamics Model in 3-D Underwater Environments.

    PubMed

    Cao, Xiang; Zhu, Daqi; Yang, Simon X

    2016-11-01

    Target search in 3-D underwater environments is a challenge in multiple autonomous underwater vehicles (multi-AUVs) exploration. This paper focuses on an effective strategy for multi-AUV target search in the 3-D underwater environments with obstacles. First, the Dempster-Shafer theory of evidence is applied to extract information of environment from the sonar data to build a grid map of the underwater environments. Second, a topologically organized bioinspired neurodynamics model based on the grid map is constructed to represent the dynamic environment. The target globally attracts the AUVs through the dynamic neural activity landscape of the model, while the obstacles locally push the AUVs away to avoid collision. Finally, the AUVs plan their search path to the targets autonomously by a steepest gradient descent rule. The proposed algorithm deals with various situations, such as static targets search, dynamic targets search, and one or several AUVs break down in the 3-D underwater environments with obstacles. The simulation results show that the proposed algorithm is capable of guiding multi-AUV to achieve search task of multiple targets with higher efficiency and adaptability compared with other algorithms.

  4. The likelihood of achieving quantified road safety targets: a binary logistic regression model for possible factors.

    PubMed

    Sze, N N; Wong, S C; Lee, C Y

    2014-12-01

    In past several decades, many countries have set quantified road safety targets to motivate transport authorities to develop systematic road safety strategies and measures and facilitate the achievement of continuous road safety improvement. Studies have been conducted to evaluate the association between the setting of quantified road safety targets and road fatality reduction, in both the short and long run, by comparing road fatalities before and after the implementation of a quantified road safety target. However, not much work has been done to evaluate whether the quantified road safety targets are actually achieved. In this study, we used a binary logistic regression model to examine the factors - including vehicle ownership, fatality rate, and national income, in addition to level of ambition and duration of target - that contribute to a target's success. We analyzed 55 quantified road safety targets set by 29 countries from 1981 to 2009, and the results indicate that targets that are in progress and with lower level of ambitions had a higher likelihood of eventually being achieved. Moreover, possible interaction effects on the association between level of ambition and the likelihood of success are also revealed.

  5. Modeling of target thermal structure effects on the performance of staring IR seekers

    NASA Astrophysics Data System (ADS)

    Borg, Eric J.

    1994-07-01

    The target thermal structure is playing a stronger role in modeling the performance of autonomous IR seekers to acquire and track targets. The impact of the target thermal structure on seeker and sensor acquisition has been previously reported. In this paper, the impact of the target's thermal structure on the acquisition and tracking capability of autonomous imaging IR seekers using staring focal plane arrays is assessed. This paper examines both the magnitude of the thermal structure, referred to as the vehicle's thermal standard deviation, and the distribution of the thermal structure, referred to as the power spectral density (PSD). The vehicle's thermal PSD is important in that it determines how much structure the seeker will see given the number of resolvable pixels the seeker has on the target. PSDs that reflect actual armored targets as well as simple warm bodies with a single hot spot are explored. PSDs that are necessary for targets to optimally match the background clutter are also addressed. In addition to the impact of the target's thermal structure, the impact of aliasing effects that can be present in staring seekers is discussed. Relative advantages of trading off resolution versus eliminating aliasing effects are presented.

  6. Ultraintense laser interaction with nanoscale target: a simple model for layer expansion and ion acceleration

    SciTech Connect

    Albright, Brian J; Yin, Lin; Hegelich, Bjoorn M; Bowers, Kevin J; Huang, Chengkun; Fernandez, Juan C; Flippo, Kirk A; Gaillard, Sandrine; Kwan, Thomas J T; Henig, Andreas; Yan, Xue Q; Tajima, Toshi; Habs, Dieter

    2009-01-01

    A simple model has been derived for the expansion of a thin (up to 100s of nm thickness), solid-density target driven by an u.ltraintense laser. In this regime, new ion acceleration mechanisms, such as the Break-Out Afterburner (BOA) [1], emerge with the potential to dramatically improve energy, efficiency, and energy spread of laser-driven ion beams. Such beams have been proposed [2] as drivers for fast ignition inertial confinement fusion [3]. Analysis of kinetic simulations of the BOA shows two dislinct times that bound the period of enhanced acceleration: t{sub 1}, when the target becomes relativistically transparent to the laser, and t{sub 2}, when the target becomes classically underdense and the enhanced acceleration terminates. A silllple dynamical model for target expansion has been derived that contains both the early, one-dimensional (lD) expansion of the target as well as three-dimensional (3D) expansion of the plasma at late times, The model assumes that expansion is slab-like at the instantaneous ion sound speed and requires as input target composition, laser intensity, laser spot area, and the efficiency of laser absorption into electron thermal energy.

  7. Leading twist nuclear shadowing, nuclear generalized parton distributions and nuclear DVCS at small x

    SciTech Connect

    Guzey, Vadim; Goeke, Klaus; Siddikov, Marat

    2009-01-01

    We generalize the leading twist theory of nuclear shadowing and calculate quark and gluon generalized parton distributions (GPDs) of spinless nuclei. We predict very large nuclear shadowing for nuclear GPDs. In the limit of the purely transverse momentum transfer, our nuclear GPDs become impact parameter dependent nuclear parton distributions (PDFs). Nuclear shadowing induces non-trivial correlations between the impact parameter $b$ and the light-cone fraction $x$. We make predictions for the deeply virtual Compton scattering (DVCS) amplitude and the DVCS cross section on $^{208}$Pb at high energies. We calculate the cross section of the Bethe-Heitler (BH) process and address the issue of the extraction of the DVCS signal from the $e A \\to e \\gamma A$ cross section. We find that the $e A \\to e \\gamma A$ differential cross section is dominated by DVCS at the momentum transfer $t$ near the minima of the nuclear form factor. We also find that nuclear shadowing leads

  8. Double parton scattering in pair production of J /ψ mesons at the LHC revisited

    NASA Astrophysics Data System (ADS)

    Borschensky, Christoph; Kulesza, Anna

    2017-02-01

    Double parton scattering (DPS) is studied for the example of J /ψ pair production in the LHCb and ATLAS experiments of the Large Hadron Collider (LHC) at center-of-mass energies of √{S }=7 , 8, and 13 TeV. We report theoretical predictions delivered to the LHCb and ATLAS Collaborations adjusted for the fiducial volumes of the corresponding measurements during run I, and we provide new predictions at 13 TeV collision energy. It is shown that DPS can lead to noticeable contributions in the distributions of longitudinal variables of the di-J /ψ system, especially at 13 TeV. The increased DPS rate in double J /ψ production at high energies will open up more possibilities for the separation of single parton scattering and DPS contributions in future studies.

  9. Off-shell single-top production at NLO matched to parton showers

    SciTech Connect

    Frederix, R.; Frixione, S.; Papanastasiou, A. S.; Prestel, S.; Torrielli, P.

    2016-06-06

    We study the hadroproduction of a Wb pair in association with a light jet, focusing on the dominant t-channel contribution and including exactly at the matrix-element level all non-resonant and off-shell effects induced by the finite top-quark width. Our simulations are accurate to the next-to-leading order in QCD, and are matched to the Herwig6 and Pythia8 parton showers through the MC@NLO method. We present phenomenological results relevant to the 8 TeV LHC, and carry out a thorough comparison to the case of on-shell t-channel single-top production. Furthermore, we formulate our approach so that it can be applied to the general case of matrix elements that feature coloured intermediate resonances and are matched to parton showers.

  10. Off-shell single-top production at NLO matched to parton showers

    DOE PAGES

    Frederix, R.; Frixione, S.; Papanastasiou, A. S.; ...

    2016-06-06

    We study the hadroproduction of a Wb pair in association with a light jet, focusing on the dominant t-channel contribution and including exactly at the matrix-element level all non-resonant and off-shell effects induced by the finite top-quark width. Our simulations are accurate to the next-to-leading order in QCD, and are matched to the Herwig6 and Pythia8 parton showers through the MC@NLO method. We present phenomenological results relevant to the 8 TeV LHC, and carry out a thorough comparison to the case of on-shell t-channel single-top production. Furthermore, we formulate our approach so that it can be applied to the generalmore » case of matrix elements that feature coloured intermediate resonances and are matched to parton showers.« less

  11. COLLINEAR SPLITTING, PARTON EVOLUTION AND THE STRANGE-QUARK ASYMMETRY OF THE NUCLEON IN NNLO QCD.

    SciTech Connect

    RODRIGO,G.CATANI,S.DE FLORIAN, D.VOGELSANG,W.

    2004-04-25

    We consider the collinear limit of QCD amplitudes at one-loop order, and their factorization properties directly in color space. These results apply to the multiple collinear limit of an arbitrary number of QCD partons, and are a basic ingredient in many higher-order computations. In particular, we discuss the triple collinear limit and its relation to flavor asymmetries in the QCD evolution of parton densities at three loops. As a phenomenological consequence of this new effect, and of the fact that the nucleon has non-vanishing quark valence densities, we study the perturbative generation of a strange-antistrange asymmetry s(x)-{bar s}(x) in the nucleon's sea.

  12. The Generalized Parton Distribution program after the Jefferson Lab 12 GeV upgrade

    SciTech Connect

    Franck Sabatie

    2009-12-01

    The Generalized Parton Distribution framework was introduced in the late 90's and describes the nucleon in a revolutionary way, correlating the information from both momentum and transverse position space into experimentally accessible functions. After a brief introduction, this article reviews the Jefferson Lab 6 GeV measurements of Deeply Virtual Compton Scattering in Halls A and B, which give a unique access to Generalized Parton Distributions (GPD). The second half of this article reviews the Jefferson Lab 12 GeV upgrade in general terms, and then focuses on the GPD program in Halls A and B. This second generation of experiments will yield more accurate, more complete data in a wider kinematical range than any experiment ever before, using the full capability of a higher beam energy, higher luminosities, upgraded detectors and refined extraction techniques.

  13. Strange quark parton distribution functions and implications for Drell-Yan boson production at the LHC

    NASA Astrophysics Data System (ADS)

    Kusina, A.; Stavreva, T.; Berge, S.; Olness, F. I.; Schienbein, I.; Kovařík, K.; Ježo, T.; Yu, J. Y.; Park, K.

    2012-05-01

    Global analyses of parton distribution functions (PDFs) have provided incisive constraints on the up and down quark components of the proton, but constraining the other flavor degrees of freedom is more challenging. Higher-order theory predictions and new data sets have contributed to recent improvements. Despite these efforts, the strange quark parton distribution function has a sizable uncertainty, particularly in the small x region. We examine the constraints from experiment and theory, and investigate the impact of this uncertainty on LHC observables. In particular, we study W/Z production to see how the s quark uncertainty propagates to these observables, and examine the extent to which precise measurements at the LHC can provide additional information on the proton flavor structure.

  14. Modeling and simulation of micro-motion in the complex warhead target

    NASA Astrophysics Data System (ADS)

    Ning, Chao; Xiao, Zhihe; Wang, Chao; Yin, Hongcheng

    2007-11-01

    The micro-motion dynamics induce the micro-Doppler effect. The rotating motion of radar targets is introduced, the formulas of micro-Doppler for point-scatter model targets are derived, and some simulations for a warhead with a sphere-head cone is given in the paper. After geometrical modeling and meshing, the static RCS of the sphere-cone is calculated with PO+PTD. On the basis of the stationary modeling, a new method of quasi-dynamic electromagnetic modeling is provided. The time domain returned signal of coning warhead could be simulated in this method, after processing by time-frequency transform, the period of coning can be obtained. The simulation results are in agreement with the theoretical result. The method by geometrical model is more accurate than point-scatters model.

  15. Polar versus Cartesian velocity models for maneuvering target tracking with IMM

    NASA Astrophysics Data System (ADS)

    Laneuville, Dann

    This paper compares various model sets in different IMM filters for the maneuvering target tracking problem. The aim is to see whether we can improve the tracking performance of what is certainly the most widely used model set in the literature for the maneuvering target tracking problem: a Nearly Constant Velocity model and a Nearly Coordinated Turn model. Our new challenger set consists of a mixed Cartesian position and polar velocity state vector to describe the uniform motion segments and is augmented with the turn rate to obtain the second model for the maneuvering segments. This paper also gives a general procedure to discretize up to second order any non-linear continuous time model with linear diffusion. Comparative simulations on an air defence scenario with a 2D radar, show that this new approach improves significantly the tracking performance in this case.

  16. One-Loop Multi-Parton Amplitudes with a Vector Boson for the LHC

    SciTech Connect

    Berger, C.F.; Bern, Z.; Dixon, L.J.; Cordero, F.Febres; Forde, D.; Ita, H.; Kosower, D.A.; Maitre, D.; /SLAC

    2008-08-11

    In this talk, we present the first, numerically stable, results for the one-loop amplitudes needed for computing W; Z + 3 jet cross sections at the LHC to next-to-leading order in the QCD coupling. We implemented these processes in BlackHat, an automated program based on on-shell methods. These methods scale very well with increasing numbers of external partons, and are applicable to a wide variety of problems of phenomenological interest at the LHC.

  17. Comparative Study of Various Algorithms for the Merging of Parton Showers and Matrix Elements in Hadronic Collisions

    SciTech Connect

    Alwall, J.; Hoche, S.; Krauss, F.; Lavesson, N.; Lonnblad, L.; Maltoni, F.; Mangano, M.L.; Moretti, M.; Papadopoulos, C.G.; Piccinini, F.; Schumann, S.; Treccani, M.; Winter, J.; Worek, M.; /SLAC /Durham U., IPPP /Lund U. /Louvain U. /CERN /Ferrara U. /INFN, Ferrara /Athens U. /INFN, Pavia /Dresden, Tech. U. /Karlsruhe U., TP /Silesia U.

    2007-06-27

    We compare different procedures for combining fixed-order tree-level matrix-element generators with parton showers. We use the case of W-production at the Tevatron and the LHC to compare different implementations of the so-called CKKW and MLM schemes using different matrix-element generators and different parton cascades. We find that although similar results are obtained in all cases, there are important differences.

  18. Partonic calculation of the two-photon exchange contribution to elastic electron-proton scattering at large momentum transfer

    SciTech Connect

    Y. C. Chen; A. Afanasev; S. J. Brodsky; C. E. Carlson; Marc Vanderhaeghen

    2004-03-01

    We estimate the two-photon exchange contribution to elastic electron-proton scattering at large momentum transfer through the scattering off a parton in the proton. We relate the process on the nucleon to the generalized parton distributions which also enter in other wide angle scattering processes. We find that when taking the polarization transfer determinations of the form factors as input, adding in the 2 photon correction, does reproduce the Rosenbluth data.

  19. Soft computing model for optimized siRNA design by identifying off target possibilities using artificial neural network model.

    PubMed

    Murali, Reena; John, Philips George; Peter S, David

    2015-05-15

    The ability of small interfering RNA (siRNA) to do posttranscriptional gene regulation by knocking down targeted genes is an important research topic in functional genomics, biomedical research and in cancer therapeutics. Many tools had been developed to design exogenous siRNA with high experimental inhibition. Even though considerable amount of work has been done in designing exogenous siRNA, design of effective siRNA sequences is still a challenging work because the target mRNAs must be selected such that their corresponding siRNAs are likely to be efficient against that target and unlikely to accidentally silence other transcripts due to sequence similarity. In some cases, siRNAs may tolerate mismatches with the target mRNA, but knockdown of genes other than the intended target could make serious consequences. Hence to design siRNAs, two important concepts must be considered: the ability in knocking down target genes and the off target possibility on any nontarget genes. So before doing gene silencing by siRNAs, it is essential to analyze their off target effects in addition to their inhibition efficacy against a particular target. Only a few methods have been developed by considering both efficacy and off target possibility of siRNA against a gene. In this paper we present a new design of neural network model with whole stacking energy (ΔG) that enables to identify the efficacy and off target effect of siRNAs against target genes. The tool lists all siRNAs against a particular target with their inhibition efficacy and number of matches or sequence similarity with other genes in the database. We could achieve an excellent performance of Pearson Correlation Coefficient (R=0. 74) and Area Under Curve (AUC=0.906) when the threshold of whole stacking energy is ≥-34.6 kcal/mol. To the best of the author's knowledge, this is one of the best score while considering the "combined efficacy and off target possibility" of siRNA for silencing a gene. The proposed model

  20. A Mathematical Model to Elucidate Brain Tumor Abrogation by Immunotherapy with T11 Target Structure

    PubMed Central

    Chaudhuri, Swapna

    2015-01-01

    T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure. We propose a mathematical model for brain tumor (glioma) and the immune system interactions, which aims in designing efficacious brain tumor therapy. The model encompasses considerations of the interactive dynamics of glioma cells, macrophages, cytotoxic T-lymphocytes (CD8+ T-cells), TGF-β, IFN-γ and the T11TS. The system undergoes sensitivity analysis, that determines which state variables are sensitive to the given parameters and the parameters are estimated from the published data. Computer simulations were used for model verification and validation, which highlight the importance of T11 target structure in brain tumor therapy. PMID:25955428

  1. A model of echolocation of multiple targets in 3D space from a single emission.

    PubMed

    Matsuo, I; Tani, J; Yano, M

    2001-07-01

    Bats, using frequency-modulated echolocation sounds, can capture a moving target in real 3D space. The process by which they are able to accomplish this, however, is not completely understood. This work offers and analyzes a model for description of one mechanism that may play a role in the echolocation process of real bats. This mechanism allows for the localization of targets in 3D space from the echoes produced by a single emission. It is impossible to locate multiple targets in 3D space by using only the delay time between an emission and the resulting echoes received at two points (i.e., two ears). To locate multiple targets in 3D space requires directional information for each target. The frequency of the spectral notch, which is the frequency corresponding to the minimum of the external ear's transfer function, provides a crucial cue for directional localization. The spectrum of the echoes from nearly equidistant targets includes spectral components of both the interference between the echoes and the interference resulting from the physical process of reception at the external ear. Thus, in order to extract the spectral component associated with the external ear, this component must first be distinguished from the spectral components associated with the interference of echoes from nearly equidistant targets. In the model presented, a computation that consists of the deconvolution of the spectrum is used to extract the external-ear-dependent component in the time domain. This model describes one mechanism that can be used to locate multiple targets in 3D space.

  2. Integrated modeling/analyses of thermal-shock effects in SNS targets

    SciTech Connect

    Taleyarkhan, R.P.; Haines, J.

    1996-06-01

    In a spallation neutron source (SNS), extremely rapid energy pulses are introduced in target materials such as mercury, lead, tungsten, uranium, etc. Shock phenomena in such systems may possibly lead to structural material damage beyond the design basis. As expected, the progression of shock waves and interaction with surrounding materials for liquid targets can be quite different from that in solid targets. The purpose of this paper is to describe ORNL`s modeling framework for `integrated` assessment of thermal-shock issues in liquid and solid target designs. This modeling framework is being developed based upon expertise developed from past reactor safety studies, especially those related to the Advanced Neutron Source (ANS) Project. Unlike previous separate-effects modeling approaches employed (for evaluating target behavior when subjected to thermal shocks), the present approach treats the overall problem in a coupled manner using state-of-the-art equations of state for materials of interest (viz., mercury, tungsten and uranium). That is, the modeling framework simultaneously accounts for localized (and distributed) compression pressure pulse generation due to transient heat deposition, the transport of this shock wave outwards, interaction with surrounding boundaries, feedback to mercury from structures, multi-dimensional reflection patterns & stress induced (possible) breakup or fracture.

  3. 3D modeling of large targets and clutter utilizing Ka band monopulse SAR

    NASA Astrophysics Data System (ADS)

    Ray, Jerry A.; Barr, Doug; Shurtz, Ric; Channell, Rob

    2006-05-01

    The U.S. Army Research, Development and Engineering Command at Redstone Arsenal, Alabama have developed a dual mode, Ka Band Radar and IIR system for the purpose of data collection and tracker algorithm development. The system is comprised of modified MMW and IIR sensors and is mounted in a stabilized ball on a UH-1 helicopter operated by Redstone Technical Test Center. Several missile programs under development require MMW signatures of multiple target and clutter scenes. Traditionally these target signatures have been successfully collected using static radars and targets mounted on a turntable to produce models from ISAR images; clutter scenes have been homogeneously characterized using information on various classes of clutter. However, current and future radar systems require models of many targets too large for turntables, as well as high resolution 3D scattering characteristics of urban and other non-homogenous clutter scenes. In partnership with industry independent research and development (IRAD) activities the U.S. Army RDEC has developed a technique for generating 3D target and clutter models using SAR imaging in the MMW spectrum. The purpose of this presentation is to provide an overview of funded projects and resulting data products with an emphasis on MMW data reduction and analysis, especially the unique 3D modeling capabilities of the monopulse radar flying SAR profiles. Also, a discussion of lessons learned and planned improvements will be presented.

  4. PROCEEDINGS OF RIKEN BNL RESEARCH CENTER WORKSHOP ENTITLED "GLOBAL ANALYSIS OF POLARIZED PARTON DESTRIBUTIONS IN THE RHIC ERA" (VOLUME 86).

    SciTech Connect

    DESHPANDE,A.; VOGELSANG, W.

    2007-10-08

    The determination of the polarized gluon distribution is a central goal of the RHIC spin program. Recent achievements in polarization and luminosity of the proton beams in RHIC, has enabled the RHIC experiments to acquire substantial amounts of high quality data with polarized proton beams at 200 and 62.4 GeV center of mass energy, allowing a first glimpse of the polarized gluon distribution at RHIC. Short test operation at 500 GeV center of mass energy has also been successful, indicating absence of any fundamental roadblocks for measurements of polarized quark and anti-quark distributions planned at that energy in a couple of years. With this background, it has now become high time to consider how all these data sets may be employed most effectively to determine the polarized parton distributions in the nucleon, in general, and the polarized gluon distribution, in particular. A global analysis of the polarized DIS data from the past and present fixed target experiments jointly with the present and anticipated RHIC Spin data is needed.

  5. Assessing potential peptide targeting ligands by quantification of cellular adhesion of model nanoparticles under flow conditions.

    PubMed

    Broda, Ellen; Mickler, Frauke Martina; Lächelt, Ulrich; Morys, Stephan; Wagner, Ernst; Bräuchle, Christoph

    2015-09-10

    Sophisticated drug delivery systems are coated with targeting ligands to improve the specific adhesion to surface receptors on diseased cells. In our study, we developed a method with which we assessed the potential of peptide ligands to specifically bind to receptor overexpressing target cells. Therefore, a microfluidic setup was used where the cellular adhesion of nanoparticles with ligand and of control nanoparticles was observed in parallel under the same experimental conditions. The effect of the ligand on cellular binding was quantified by counting the number of adhered nanoparticles with ligand and differently labeled control nanoparticles on single cells after incubation under flow conditions. To provide easy-to-synthesize, stable and reproducible nanoparticles which mimic the surface characteristics of drug delivery systems and meet the requirements for quantitative analysis, latex beads based on amine-modified polystyrene were used as model nanoparticles. Two short peptides were tested to serve as targeting ligand on the beads by increasing the specific binding to HuH7 cells. The c-Met binding peptide cMBP2 was used for hepatocyte growth factor receptor (c-Met) targeting and the peptide B6 for transferrin receptor (TfR) targeting. The impact of the targeting peptide on binding was investigated by comparing the beads with ligand to different internal control beads: 1) without ligand and tailored surface charge (electrostatic control) and 2) with scrambled peptide and similar surface charge, but a different amino acid sequence (specificity control). Our results demonstrate that the method is very useful to select suitable targeting ligands for specific nanoparticle binding to receptor overexpressing tumor cells. We show that the cMBP2 ligand specifically enhances nanoparticle adhesion to target cells, whereas the B6 peptide mediates binding to tumor cells mainly by nonspecific interactions. All together, we suggest that cMBP2 is a suitable choice for

  6. Modeling cognitive effects on visual search for targets in cluttered backgrounds

    NASA Astrophysics Data System (ADS)

    Snorrason, Magnus; Ruda, Harald; Hoffman, James

    1998-07-01

    To understand how a human operator performs visual search in complex scenes, it is necessary to take into account top- down cognitive biases in addition to bottom-up visual saliency effects. We constructed a model to elucidate the relationship between saliency and cognitive effects in the domain of visual search for distant targets in photo- realistic images of cluttered scenes. In this domain, detecting targets is difficult and requires high visual acuity. Sufficient acuity is only available near the fixation point, i.e. in the fovea. Hence, the choice of fixation points is the most important determinant of whether targets get detected. We developed a model that predicts the 2D distribution of fixation probabilities directly from an image. Fixation probabilities were computed as a function of local contrast (saliency effect) and proximity to the horizon (cognitive effect: distant targets are more likely to be found c close to the horizon). For validation, the model's predictions were compared to ensemble statistics of subjects' actual fixation locations, collected with an eye- tracker. The model's predictions correlated well with the observed data. Disabling the horizon-proximity functionality of the model significantly degraded prediction accuracy, demonstrating that cognitive effects must be accounted for when modeling visual search.

  7. Analytic Guided-Search Model of Human Performance Accuracy in Target- Localization Search Tasks

    NASA Technical Reports Server (NTRS)

    Eckstein, Miguel P.; Beutter, Brent R.; Stone, Leland S.

    2000-01-01

    Current models of human visual search have extended the traditional serial/parallel search dichotomy. Two successful models for predicting human visual search are the Guided Search model and the Signal Detection Theory model. Although these models are inherently different, it has been difficult to compare them because the Guided Search model is designed to predict response time, while Signal Detection Theory models are designed to predict performance accuracy. Moreover, current implementations of the Guided Search model require the use of Monte-Carlo simulations, a method that makes fitting the model's performance quantitatively to human data more computationally time consuming. We have extended the Guided Search model to predict human accuracy in target-localization search tasks. We have also developed analytic expressions that simplify simulation of the model to the evaluation of a small set of equations using only three free parameters. This new implementation and extension of the Guided Search model will enable direct quantitative comparisons with human performance in target-localization search experiments and with the predictions of Signal Detection Theory and other search accuracy models.

  8. Subchannel thermal-hydraulic modeling of an APT tungsten target rod bundle

    SciTech Connect

    Hamm, L.L.; Shadday, M.A. Jr.

    1997-09-01

    The planned target for the Accelerator Production of Tritium (APT) neutron source consists of an array of tungsten rod bundles through which D{sub 2}O coolant flows axially. Here, a scoping analysis of flow through an APT target rod bundle was conducted to demonstrate that lateral cross-flows are important, and therefore subchannel modeling is necessary to accurately predict thermal-hydraulic behavior under boiling conditions. A local reactor assembly code, FLOWTRAN, was modified to model axial flow along the rod bundle as flow through three concentric heated annular passages.

  9. Modeling human target acquisition in ground-to-air weapon systems

    NASA Technical Reports Server (NTRS)

    Phatak, A. V.; Mohr, R. L.; Vikmanis, M.; Wei, K. C.

    1982-01-01

    The problems associated with formulating and validating mathematical models for describing and predicting human target acquisition response are considered. In particular, the extension of the human observer model to include the acquisition phase as well as the tracking segment is presented. Relationship of the Observer model structure to the more complex Standard Optimal Control model formulation and to the simpler Transfer Function/Noise representation is discussed. Problems pertinent to structural identifiability and the form of the parameterization are elucidated. A systematic approach toward the identification of the observer acquisition model parameters from ensemble tracking error data is presented.

  10. The analytic model of a laser-accelerated plasma target and its stability

    NASA Astrophysics Data System (ADS)

    Khudik, V.; Yi, S. A.; Siemon, C.; Shvets, G.

    2014-01-01

    A self-consistent kinetic theory of a laser-accelerated plasma target with distributed electron/ion densities is developed. The simplified model assumes that after an initial transition period the bulk of cold ions are uniformly accelerated by the self-consistent electric field generated by hot electrons trapped in combined ponderomotive and electrostatic potentials. Several distinct target regions (non-neutral ion tail, non-neutral electron sheath, and neutral plasma bulk) are identified and analytically described. It is shown analytically that such laser-accelerated finite-thickness target is susceptible to Rayleigh-Taylor (RT) instability. Particle-in-cell simulations of the seeded perturbations of the plasma target reveal that, for ultra-relativistic laser intensities, the growth rate of the RT instability is depressed from the analytic estimates.

  11. Targeting cancer’s weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model

    PubMed Central

    Lineweaver, Charles H.; Davies, Paul C.W.; Vincent, Mark D.

    2014-01-01

    In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target-the-weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in immunosuppressed tumor environments is an irreversible weakness of cancer that can be exploited by creating a challenge that only the presence of adaptive immunity can meet. This leaves tumor cells more vulnerable than healthy tissue to pathogenic attack. Such a target-the-weakness therapeutic strategy has broad applications, and contrasts with current therapies that target the main strength of cancer: cell proliferation. PMID:25043755

  12. The analytic model of a laser-accelerated plasma target and its stability

    SciTech Connect

    Khudik, V. Yi, S. A.; Siemon, C.; Shvets, G.

    2014-01-15

    A self-consistent kinetic theory of a laser-accelerated plasma target with distributed electron/ion densities is developed. The simplified model assumes that after an initial transition period the bulk of cold ions are uniformly accelerated by the self-consistent electric field generated by hot electrons trapped in combined ponderomotive and electrostatic potentials. Several distinct target regions (non-neutral ion tail, non-neutral electron sheath, and neutral plasma bulk) are identified and analytically described. It is shown analytically that such laser-accelerated finite-thickness target is susceptible to Rayleigh-Taylor (RT) instability. Particle-in-cell simulations of the seeded perturbations of the plasma target reveal that, for ultra-relativistic laser intensities, the growth rate of the RT instability is depressed from the analytic estimates.

  13. ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms

    PubMed Central

    2011-01-01

    Background Zinc Finger Nucleases (ZFNs) have tremendous potential as tools to facilitate genomic modifications, such as precise gene knockouts or gene replacements by homologous recombination. ZFNs can be used to advance both basic research and clinical applications, including gene therapy. Recently, the ability to engineer ZFNs that target any desired genomic DNA sequence with high fidelity has improved significantly with the introduction of rapid, robust, and publicly available techniques for ZFN design such as the Oligomerized Pool ENgineering (OPEN) method. The motivation for this study is to make resources for genome modifications using OPEN-generated ZFNs more accessible to researchers by creating a user-friendly interface that identifies and provides quality scores for all potential ZFN target sites in the complete genomes of several model organisms. Description ZFNGenome is a GBrowse-based tool for identifying and visualizing potential target sites for OPEN-generated ZFNs. ZFNGenome currently includes a total of more than 11.6 million potential ZFN target sites, mapped within the fully sequenced genomes of seven model organisms; S. cerevisiae, C. reinhardtii, A. thaliana, D. melanogaster, D. rerio, C. elegans, and H. sapiens and can be visualized within the flexible GBrowse environment. Additional model organisms will be included in future updates. ZFNGenome provides information about each potential ZFN target site, including its chromosomal location and position relative to transcription initiation site(s). Users can query ZFNGenome using several different criteria (e.g., gene ID, transcript ID, target site sequence). Tracks in ZFNGenome also provide "uniqueness" and ZiFOpT (Zinc Finger OPEN Targeter) "confidence" scores that estimate the likelihood that a chosen ZFN target site will function in vivo. ZFNGenome is dynamically linked to ZiFDB, allowing users access to all available information about zinc finger reagents, such as the effectiveness of a given

  14. Dose correction for the Michaelis-Menten approximation of the target-mediated drug disposition model.

    PubMed

    Yan, Xiaoyu; Krzyzanski, Wojciech

    2012-04-01

    The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived based on the rapid binding (RB) or quasi steady-state (QSS) assumptions that implied that the target and drug binding and dissociation were in equilibrium. However, the initial dose for an IV bolus injection for the M-M model did not account for a fraction bound to the target. We postulated a correction to an initial condition that was consistent with the assumptions underlying the M-M approximation. We determined that the difference between the injected dose and one that should be used for the initial condition is equal to the amount of drug bound to the target upon reaching the equilibrium. We also observed that the corrected initial condition made the internalization rate constant an identifiable parameter that was not for the original M-M model. Finally, we performed a simulation exercise to check if the correction will impact the model performance and the bias of the M-M parameter estimates. We used literature data to simulate plasma drug concentrations described by the RB/QSS TMDD model. The simulated data were refitted by both models. All the parameters estimated from the original M-M model were substantially biased. On the other hand, the corrected M-M is able to accurately estimate these parameters except for equilibrium constant K(m). Weighted sum of square residual and Akaike information criterion suggested a better performance of the corrected M-M model compared with the original M-M model. Further studies are necessary to determine the importance of this correction for the M-M model applications to analysis of TMDD driven PK data.

  15. Modeling of RF Magnetron Plasma in N2 with dielectric target

    NASA Astrophysics Data System (ADS)

    Arbeltier, Steven; Revel, Adrien; Sabary, Frédéric; Secouard, Christophe; Minea, Tiberiu

    2016-09-01

    Thin film batteries technology requires a solid electrolyte suitable for its operation. One option is to use LiPON deposited from Li3PO4 target by radio frequency magnetron sputtering in nitrogen plasma. Despite the successful implementation of this technology, the processes occurring into the plasma and at the substrate during deposition need to be well understood. Modelling is an interesting approach to study the undergoing phenomena such as the quantification of plasma species, the potential evolution in the reactor, the shape of the racetrack and the trajectories of sputtered species. The present results are obtained from two models, (i) a 0D model which describes the plasma kinetic and (ii) a 2D model assuming the axial symmetry. The latter uses a Particle-In-Cell Monte-Carlo approach and self-consistently describes the plasma creation and charged particles trajectories in the reactor. The geometry and the magnetic field correspond to a real CEA-LETI reactor .The dielectric target is 6'' diameter. Radiofrequency polarization of the target is taken into account in the model. Results on the evolution of ions density in plasma, the electric-field and the self-bias on the target, are discussed.

  16. A Canopy Density Model for Planar Orchard Target Detection Based on Ultrasonic Sensors.

    PubMed

    Li, Hanzhe; Zhai, Changyuan; Weckler, Paul; Wang, Ning; Yang, Shuo; Zhang, Bo

    2016-12-24

    Orchard target-oriented variable rate spraying is an effective method to reduce pesticide drift and excessive residues. To accomplish this task, the orchard targets' characteristic information is needed to control liquid flow rate and airflow rate. One of the most important characteristics is the canopy density. In order to establish the canopy density model for a planar orchard target which is indispensable for canopy density calculation, a target density detection testing system was developed based on an ultrasonic sensor. A time-domain energy analysis method was employed to analyze the ultrasonic signal. Orthogonal regression central composite experiments were designed and conducted using man-made canopies of known density with three or four layers of leaves. Two model equations were obtained, of which the model for the canopies with four layers was found to be the most reliable. A verification test was conducted with different layers at the same density values and detecting distances. The test results showed that the relative errors of model density values and actual values of five, four, three and two layers of leaves were acceptable, while the maximum relative errors were 17.68%, 25.64%, 21.33% and 29.92%, respectively. It also suggested the model equation with four layers had a good applicability with different layers which increased with adjacent layers.

  17. Radiosensitivity and relative biological effectiveness based on a generalized target model

    PubMed Central

    Zhao, Lei; Wu, Di; Mi, Dong; Sun, Yeqing

    2017-01-01

    By considering both cellular repair effects and indirect effects of radiation, we have generalized the traditional target model, and made it have a linear–quadratic–linear characteristic. To assess the repair capacity–dependent radiosensitivity and relative biological effectiveness (RBE), the generalized target model was used to fit the survival of human normal embryonic lung fibroblast MRC-5 cells in the G0 and G1 phases after various types of radiations. The fitting results indicate that the generalized target model works well in the dose ranges considered. The resulting calculations qualitatively show that the parameter ratio (a/V) in the model could represent the cellular repair capacity. In particular, the significant linear correlations between radiosensitivity/RBE and cellular repair capacity are observed for different slopes of the linear regression curves. These results show that the radiosensitivity and RBE depend on the cellular repair capacity and can be regulated by linear energy transfer. These analyses suggest that the ratio a/V in the generalized target model can also be used for radiation damage assessment in radiotherapy. PMID:27422933

  18. An Analytic Model for the Success Rate of a Robotic Actuator System in Hitting Random Targets

    PubMed Central

    Bradley, Stuart

    2015-01-01

    Autonomous robotic systems are increasingly being used in a wide range of applications such as precision agriculture, medicine, and the military. These systems have common features which often includes an action by an “actuator” interacting with a target. While simulations and measurements exist for the success rate of hitting targets by some systems, there is a dearth of analytic models which can give insight into, and guidance on optimization, of new robotic systems. The present paper develops a simple model for estimation of the success rate for hitting random targets from a moving platform. The model has two main dimensionless parameters: the ratio of actuator spacing to target diameter; and the ratio of platform distance moved (between actuator “firings”) to the target diameter. It is found that regions of parameter space having specified high success are described by simple equations, providing guidance on design. The role of a “cost function” is introduced which, when minimized, provides optimization of design, operating, and risk mitigation costs. PMID:26610500

  19. Numerical modeling for energy transport and isochoric heating in ultra-fast heated high Z target

    NASA Astrophysics Data System (ADS)

    Mishra, Rohini; Sentoku, Yasuhiko; Hakel, Peter; Mancini, Roberto C.

    2010-11-01

    Collisional Particle-in-Cell (PIC) code is an effective tool to study extreme energy density conditions achieved in intense laser-solid interactions. In the continuous process of developing PIC code, we have recently implemented models to incorporate dynamic ionizations, namely Saha and Thomas Fermi, and radiation cooling (due to Bremsstrahlung and line emissions). We have also revised the existing collision model to take into account bounded electrons in dynamically ionizing target (partially ionized target). One-dimensional PIC simulation of a gold target with new collision model shows strong local heating in a micron distance due to shorter stopping range of fast electrons, which reflects the increased collision frequency due to bound electrons. The peak temperature in the heated region drops significantly due to the radiation cooling to a level of a few hundred eV from keV. We also discuss the target Z dependence on radiation loss and two-dimensional effects such as the resistive magnetic fields in the hot electron transport in metal targets.

  20. An Analytic Model for the Success Rate of a Robotic Actuator System in Hitting Random Targets.

    PubMed

    Bradley, Stuart

    2015-11-20

    Autonomous robotic systems are increasingly being used in a wide range of applications such as precision agriculture, medicine, and the military. These systems have common features which often includes an action by an "actuator" interacting with a target. While simulations and measurements exist for the success rate of hitting targets by some systems, there is a dearth of analytic models which can give insight into, and guidance on optimization, of new robotic systems. The present paper develops a simple model for estimation of the success rate for hitting random targets from a moving platform. The model has two main dimensionless parameters: the ratio of actuator spacing to target diameter; and the ratio of platform distance moved (between actuator "firings") to the target diameter. It is found that regions of parameter space having specified high success are described by simple equations, providing guidance on design. The role of a "cost function" is introduced which, when minimized, provides optimization of design, operating, and risk mitigation costs.

  1. Vapor shielding models and the energy absorbed by divertor targets during transient events

    NASA Astrophysics Data System (ADS)

    Skovorodin, D. I.; Pshenov, A. A.; Arakcheev, A. S.; Eksaeva, E. A.; Marenkov, E. D.; Krasheninnikov, S. I.

    2016-02-01

    The erosion of divertor targets caused by high heat fluxes during transients is a serious threat to ITER operation, as it is going to be the main factor determining the divertor lifetime. Under the influence of extreme heat fluxes, the surface temperature of plasma facing components can reach some certain threshold, leading to an onset of intense material evaporation. The latter results in formation of cold dense vapor and secondary plasma cloud. This layer effectively absorbs the energy of the incident plasma flow, turning it into its own kinetic and internal energy and radiating it. This so called vapor shielding is a phenomenon that may help mitigating the erosion during transient events. In particular, the vapor shielding results in saturation of energy (per unit surface area) accumulated by the target during single pulse of heat load at some level Emax. Matching this value is one of the possible tests to verify complicated numerical codes, developed to calculate the erosion rate during abnormal events in tokamaks. The paper presents three very different models of vapor shielding, demonstrating that Emax depends strongly on the heat pulse duration, thermodynamic properties, and evaporation energy of the irradiated target material. While its dependence on the other shielding details such as radiation capabilities of material and dynamics of the vapor cloud is logarithmically weak. The reason for this is a strong (exponential) dependence of the target material evaporation rate, and therefore the "strength" of vapor shield on the target surface temperature. As a result, the influence of the vapor shielding phenomena details, such as radiation transport in the vapor cloud and evaporated material dynamics, on the Emax is virtually completely masked by the strong dependence of the evaporation rate on the target surface temperature. However, the very same details define the amount of evaporated particles, needed to provide an effective shielding to the target, and

  2. Investigating the role of partonic and hadronic dynamics in mass splitting of elliptic anisotropy in p -Pb collisions at √{sN N}=5.02 TeV

    NASA Astrophysics Data System (ADS)

    Sarkar, Debojit; Choudhury, Subikash; Chattopadhyay, Subhasis

    2016-10-01

    The mass ordering of v2hadron is regarded as one of the key signatures of collective behavior in ultrarelativistic heavy ion collisions. This observation has been found to be in compliance with the hydrodynamical response of a strongly interacting system to the initial spatial anisotropy. Flow coefficients measured with identified particles in p -Pb/d -Au collisions have shown similar mass-splitting of v2hadron indicating towards the presence of collective dynamics in small collision systems. Arguably, the small size in the overlap geometry of such colliding systems may not be suitable for hydrodynamical treatment that demands an early thermalization. Studies based on a multiphase transport model (AMPT) suggest that elliptic or triangular anisotropy is primarily due to the escape mechanism of partons rather than hydro-like collectivity and mass ordering of v2hadron can be generated from coalescence dynamics as implemented in string melting version of AMPT even when parton azimuthal directions are randomized. In this work, studies have been performed on p -Pb collisions at √{sN N}=5.02 TeV using AMPT model which has been found to explain the elliptic and triangular flow in such a system where the escape mechanism is the dominant source of flow generation. We report that the mass splitting of v2hadron can originate independently both at the partonic and hadronic level in the string melting version of the AMPT model.

  3. Advanced EM Modeling in Support of Buried Target Detection and Identification

    NASA Astrophysics Data System (ADS)

    Lavely, Eugene

    2012-02-01

    The detection and discrimination of buried unexploded ordnance is essential for restoration of millions of acres of munitions testing grounds to public use. Public safety is paramount so high detection probability is essential, and accurate discrimination is key for economically feasible remediation. Time domain electromagnetic (TDEM) induction methods in principle have the capability to address these criteria. The transmitter loop current pulse generates a magnetic field in the target region. This changing applied field, especially as the pulse terminates, induces currents in the target, generating a scattered magnetic field. The decaying scattered field, following pulse termination, induces the measured voltage in the receiver loop. There are three different regimes that one may identify in the voltage time traces: early, intermediate, and late time. At very early time, immediately following pulse termination, the currents are confined to the immediate surface of the target. The initial diffusion of these currents into the target interior leads to a 1/2 power law decay for nonferrous targets, (3/2 for ferrous targets). At intermediate time, as the currents penetrate the deeper target interior, the power law crosses over to a multi-exponential decay, representing the simultaneous presence of a finite set of exponentially decaying modes. Finally, at late time only the single, slowest decaying mode survives. At intermediate- to late-time our mean field algorithm models the dynamics by computing as large a number as possible of the modes, and determining the excitation level of each. At early time, the power law arises from a superposition of an essentially infinite number of exponentials, and a complementary theory, based on the detailed dynamics of the initial very thin surface current sheet, has been developed instead. We pre-compute intrinsic properties of modes containing all discrimination information of targets, and use this for nearly real-time inversion of

  4. Electroproduction in the Target Fragmentation Region

    NASA Astrophysics Data System (ADS)

    Avagyan, Harut

    2014-09-01

    The Semi-Inclusive DIS process in the Target Fragmentation Region (TFR), when the hadron is produced in the fragmentation process of the target remnants, can be described through the so-called Fracture Functions (FFs). They represent the joint probability of producing the final hadron from the target remnants, when a parton of the target nucleon is struck by the virtual photon in a hard scattering process. Like the ordinary parton distribution functions, the FFs are universal objects, thus they can be measured in one experiment at a given hard scale and then used to make predictions for other experiments, at another hard scale. Measurements of the Lambda multiplicities and polarization asymmetries in TFR, in particular, will provide information on corresponding Fracture Functions. The study of its Q2 dependence at JLab and EIC also will test the perturbative framework implied by Fracture Functions, simultaneously encoding the information on the interacting parton and on the fragmentation of the spectator system. We will present ongoing studies of electroproduction in TFR at Jefferson Lab, and proposed future measurement at upgraded JLab and Electron Ion Collider.

  5. Patient-Derived Xenograft Models to Improve Targeted Therapy in Epithelial Ovarian Cancer Treatment

    PubMed Central

    Scott, Clare L.; Becker, Marc A.; Haluska, Paul; Samimi, Goli

    2013-01-01

    Despite increasing evidence that precision therapy targeted to the molecular drivers of a cancer has the potential to improve clinical outcomes, high-grade epithelial ovarian cancer (OC) patients are currently treated without consideration of molecular phenotype, and predictive biomarkers that could better inform treatment remain unknown. Delivery of precision therapy requires improved integration of laboratory-based models and cutting-edge clinical research, with pre-clinical models predicting patient subsets that will benefit from a particular targeted therapeutic. Patient-derived xenografts (PDXs) are renewable tumor models engrafted in mice, generated from fresh human tumors without prior in vitro exposure. PDX models allow an invaluable assessment of tumor evolution and adaptive response to therapy. PDX models have been applied to pre-clinical drug testing and biomarker identification in a number of cancers including ovarian, pancreatic, breast, and prostate cancers. These models have been shown to be biologically stable and accurately reflect the patient tumor with regards to histopathology, gene expression, genetic mutations, and therapeutic response. However, pre-clinical analyses of molecularly annotated PDX models derived from high-grade serous ovarian cancer (HG-SOC) remain limited. In vivo response to conventional and/or targeted therapeutics has only been described for very small numbers of individual HG-SOC PDX in conjunction with sparse molecular annotation and patient outcome data. Recently, two consecutive panels of epithelial OC PDX correlate in vivo platinum response with molecular aberrations and source patient clinical outcomes. These studies underpin the value of PDX models to better direct chemotherapy and predict response to targeted therapy. Tumor heterogeneity, before and following treatment, as well as the importance of multiple molecular aberrations per individual tumor underscore some of the important issues addressed in PDX models

  6. A model for forming airborne synthetic aperture radar images of underground targets

    SciTech Connect

    Doerry, A.W.

    1994-01-01

    Synthetic Aperture Radar (SAR) from an airborne platform has been proposed for imaging targets beneath the earth`s surface. The propagation of the radar`s energy within the ground, however, is much different than in the earth`s atmosphere. The result is signal refraction, echo delay, propagation losses, dispersion, and volumetric scattering. These all combine to make SAR image formation from an airborne platform much more challenging than a surface imaging counterpart. This report treats the ground as a lossy dispersive half-space, and presents a model for the radar echo based on measurable parameters. The model is then used to explore various imaging schemes, and image properties. Dynamic range is discussed, as is the impact of loss on dynamic range. Modified window functions are proposed to mitigate effects of sidelobes of shallow targets overwhelming deeper targets.

  7. A model for combined targeting and tracking tasks in computer applications.

    PubMed

    Senanayake, Ransalu; Hoffmann, Errol R; Goonetilleke, Ravindra S

    2013-11-01

    Current models for targeted-tracking are discussed and shown to be inadequate as a means of understanding the combined task of tracking, as in the Drury's paradigm, and having a final target to be aimed at, as in the Fitts' paradigm. It is shown that the task has to be split into components that are, in general, performed sequentially and have a movement time component dependent on the difficulty of the individual component of the task. In some cases, the task time may be controlled by the Fitts' task difficulty, and in others, it may be dominated by the Drury's task difficulty. Based on an experiment carried out that captured movement time in combinations of visually controlled and ballistic movements, a model for movement time in targeted-tracking was developed.

  8. Comparison of Different INC Physical Models of MCNPX to Compute Spallation Neutronics of LBE Target

    NASA Astrophysics Data System (ADS)

    Feghhi, Seyed Amir Hossein; Gholamzadeh, Zohreh; Tenreiro, Claudio; Alipoor, Zahra

    2015-04-01

    Spallation particles can utilize in different fields such as neutron scattering studies, external source for burning spent fuel as well as running subcritical reactors. Different computational particle transport codes are widely used to model spallation process into the heavy targets. Among these codes, MCNPX 2.6.0 comprises various intra nuclear cascade models for spallation calculations. Impact of different intra nuclear cascade models on calculation of neutronic parameters of LBE target has been evaluated in this work. Escaped neutron yield, energy deposition and residual nuclei production in the spallation target has been calculated using the physical models. A comparison between the computational and experimental has been carried out to validate the computational data. The simulation data showed there is a good conformity between the obtained data from Bertini/Drenser and Isabel/Drenser. The data achieved by Bertini/Abla and Isabel/Abla models are close to each other for the studied parameters as well. Among the studied models, CEM showed more discrepancies with experimental and other computational data. According to the obtained data, INCL4/Drenser, INCL4/Abla and Isabel/Drenser models can meet more agreements with experimental data.

  9. Identifying targets for topical RNAi therapeutics in psoriasis: assessment of a new in vitro psoriasis model.

    PubMed

    Bracke, S; Desmet, E; Guerrero-Aspizua, S; Tjabringa, S G; Schalkwijk, J; Van Gele, M; Carretero, M; Lambert, J

    2013-08-01

    Diseases of the skin are amenable to RNAi-based therapies and targeting key components in the pathophysiology of psoriasis using RNAi may represent a successful new therapeutic strategy. We aimed to develop a straightforward and highly reproducible in vitro psoriasis model useful to study the effects of gene knockdown by RNAi and to identify new targets for topical RNAi therapeutics. We evaluated the use of keratinocytes derived from psoriatic plaques and normal human keratinocytes (NHKs). To induce a psoriatic phenotype in NHKs, combinations of pro-inflammatory cytokines (IL-1α, IL-17A, IL-6 and TNF-α) were tested. The model based on NHK met our needs of a reliable and predictive preclinical model, and this model was further selected for gene expression analyses, comprising a panel of 55 psoriasis-associated genes and five micro-RNAs (miRNAs). Gene silencing studies were conducted by using small interfering RNAs (siRNAs) and miRNA inhibitors directed against potential target genes such as CAMP and DEFB4 and miRNAs such as miR-203. We describe a robust and highly reproducible in vitro psoriasis model that recapitulates expression of a large panel of genes and miRNAs relevant to the pathogenesis of psoriasis. Furthermore, we show that our model is a powerful first step model system for testing and screening RNAi-based therapeutics.

  10. A model for low energy thick-target bremsstrahlung produced in an SEM

    NASA Astrophysics Data System (ADS)

    Quarles, C. A.; Semaan, Mars E.

    1999-10-01

    A model for thick-target bremsstrahlung has been developed based on the approach used by Storm ( E. Storm, Phys. Rev. A.5, 2328 (1972).)and Ambrose et al. ( R. Ambrose, D. L. Kahler, H. E. Lehtihet and C. A. Quarles, Nucl. Inst. Meth. Phys. Res. B 56/57, 327 (1991).). The model integrates the thin-target cross sections ( Kissel, C. A. Quarles and R. H. Pratt, Atom. Data Nucl. Data Tables 28, 381 (1983).) over the target taking into account electron energy loss, electron back scattering and photon attenuation. The model is compared with measurements in reflection mode for atomic numbers from 4 to 79 and for electron energies between 5 and 25 keV. A JEOL JSM 6100 Scanning Electron Microscope is used for the electron beam, and a Link Si(Li) detector for the bremsstrahlung spectrum. Very good agreement is found between the model and the experimental results. Sensitivity of the model to various assumptions about electron back scattering and photon attenuation will be discussed. The model is also found to do as well as a recent empirical model ( Trincavelli, G. Castellano and J. A. Riveros, X-Ray Spectr. 27, 81 (1998).) in describing the photon energy dependence of the bremsstrahlung spectrum.

  11. A statistical model for point-based target registration error with anisotropic fiducial localizer error.

    PubMed

    Wiles, Andrew D; Likholyot, Alexander; Frantz, Donald D; Peters, Terry M

    2008-03-01

    Error models associated with point-based medical image registration problems were first introduced in the late 1990s. The concepts of fiducial localizer error, fiducial registration error, and target registration error are commonly used in the literature. The model for estimating the target registration error at a position r in a coordinate frame defined by a set of fiducial markers rigidly fixed relative to one another is ubiquitous in the medical imaging literature. The model has also been extended to simulate the target registration error at the point of interest in optically tracked tools. However, the model is limited to describing the error in situations where the fiducial localizer error is assumed to have an isotropic normal distribution in R3. In this work, the model is generalized to include a fiducial localizer error that has an anisotropic normal distribution. Similar to the previous models, the root mean square statistic rms tre is provided along with an extension that provides the covariance Sigma tre. The new model is verified using a Monte Carlo simulation and a set of statistical hypothesis tests. Finally, the differences between the two assumptions, isotropic and anisotropic, are discussed within the context of their use in 1) optical tool tracking simulation and 2) image registration.

  12. Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation.

    PubMed

    Ayyaswamy, Portonovo S; Muzykantov, Vladimir; Eckmann, David M; Radhakrishnan, Ravi

    2013-02-01

    This review discusses current progress and future challenges in the numerical modeling of targeted drug delivery using functionalized nanocarriers (NC). Antibody coated nanocarriers of various size and shapes, also called functionalized nanocarriers, are designed to be injected in the vasculature, whereby they undergo translational and rotational motion governed by hydrodynamic interaction with blood particulates as well as adhesive interactions mediated by the surface antibody binding to target antigens/receptors on cell surfaces. We review current multiscale modeling approaches rooted in computational fluid dynamics and nonequilibrium statistical mechanics to accurately resolve fluid, thermal, as well as adhesive interactions governing nanocarrier motion and their binding to endothelial cells lining the vasculature. We also outline current challenges and unresolved issues surrounding the modeling methods. Experimental approaches in pharmacology and bioengineering are discussed briefly from the perspective of model validation.

  13. Reaction dynamics of {sup 34-38}Mg projectile with carbon target using Glauber model

    SciTech Connect

    Shama, Mahesh K.; Panda, R. N.; Sharma, Manoj K.; Patra, S. K.

    2015-08-28

    We have studied nuclear reaction cross-sections for {sup 34-38}Mg isotopes as projectile with {sup 12}C target at projectile energy 240AMeV using Glauber model with the conjunction of densities from relativistic mean filed formalism. We found good agreement with the available experimental data. The halo status of {sup 37}Mg is also investigated.

  14. New Model for Ecosystem Management Interpretation: Target Audiences on Military Lands.

    ERIC Educational Resources Information Center

    Jacobson, Susan K.; Marynowski, Susan B.

    1998-01-01

    An interpretation model focusing on audience characteristics guided development of an ecosystem-management interpretive program targeting military leaders and planners at Eglin Air Force Base (Florida). Of five interpretative media tested, print mass media were most successful in increasing ecosystem knowledge and enhancing attitudes of both…

  15. TARGETED DELIVERY OF INHALED PHARMACEUTICALS USING AN IN SILICO DOSIMETRY MODEL

    EPA Science Inventory

    We present an in silico dosimetry model which can be used for inhalation toxicology (risk assessment of inhaled air pollutants) and aerosol therapy ( targeted delivery of inhaled drugs). This work presents scientific and clinical advances beyond the development of the original in...

  16. A Mathematical Model for Calculating Detection Probability of a Diffusion Target.

    DTIC Science & Technology

    1984-09-01

    diffusion model. This model assumes that there is a stationary searcher which has a " cookie -cutter" sensor with radius R. In order to construct this model...stationary searcher which has a " cookie -cutter" sensor with radius R. In order to construct this model, a Monte Carlo simulation program is used to generate...of radius R. The dete:tior. probability of a target inside of this disk is 1 and outside is 0. :he searcher thus has a " cookie - cutter" sensor with

  17. Target identification and navigation performance modeling of a passive millimeter wave imager.

    PubMed

    Jacobs, Eddie L; Furxhi, Orges

    2010-07-01

    Human task performance using a passive interferometric millimeter wave imaging sensor is modeled using a task performance modeling approach developed by the U.S. Army Night Vision and Electronic Sensors Directorate. The techniques used are illustrated for an imaging system composed of an interferometric antenna array, optical upconversion, and image formation using a shortwave infrared focal plane array. Two tasks, target identification and pilotage, are modeled. The effects of sparse antenna arrays on task performance are considered. Applications of this model include system trade studies for concealed weapon identification, navigation in fog, and brownout conditions.

  18. Spin-dependent parton distributions in the nucleon

    SciTech Connect

    I.C. Cloet; W. Bentz; A.W. Thomas

    2005-04-01

    Spin-dependent quark light-cone momentum distributions are calculated for a nucleon in the nuclear medium. We utilize a modified NJL model where the nucleon is described as a composite quark-diquark state. Scalar and vector mean fields are incorporated in the nuclear medium and these fields couple to the confined quarks in the nucleon. The effect of these fields on the spin-dependent distributions and consequently the axial charges is investigated. Our results for the ''spin-dependent EMC effect'' are also discussed.

  19. Fighting Fire with Fire: Modeling the Datacenter-Scale Effects of Targeted Superlattice Thermal Management

    DTIC Science & Technology

    2011-01-01

    Fighting Fire with Fire : Modeling the Datacenter-Scale Effects of Targeted Superlattice Thermal Management Susmit Biswas?, Mohit Tiwari†, Timothy...Sherwood† Luke Theogarajan‡, Frederic T. Chong† Lawrence Livermore National Laboratory, Livermore, CA - 94550, USA? Department of Computer Science , UC...JUN 2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Fighting Fire with Fire : Modeling the Datacenter

  20. Target Impact Detection Algorithm Using Computer-aided Design (CAD) Model Geometry

    DTIC Science & Technology

    2014-09-01

    UNCLASSIFIED AD-E403 558 Technical Report ARMET-TR-13024 TARGET IMPACT DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ...DETECTION ALGORITHM USING COMPUTER-AIDED DESIGN ( CAD ) MODEL GEOMETRY 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...This report documents a method and algorithm to export geometry from a three-dimensional, computer-aided design ( CAD ) model in a format that can be

  1. Computational modeling of pulsed-power-driven magnetized target fusion experiments

    SciTech Connect

    Sheehey, P.; Kirkpatrick, R.; Lindemuth, I.

    1995-08-01

    Direct magnetic drive using electrical pulsed power has been considered impractically slow for traditional inertial confinement implosion of fusion targets. However, if the target contains a preheated, magnetized plasma, magnetothermal insulation may allow the near-adiabatic compression of such a target to fusion conditions on a much slower time scale. 100-MJ-class explosive flux compression generators with implosion kinetic energies far beyond those available with conventional fusion drivers, are an inexpensive means to investigate such magnetized target fusion (MTF) systems. One means of obtaining the preheated and magnetized plasma required for an MTF system is the recently reported {open_quotes}MAGO{close_quotes} concept. MAGO is a unique, explosive-pulsed-power driven discharge in two cylindrical chambers joined by an annular nozzle. Joint Russian-American MAGO experiments have reported D-T neutron yields in excess of 10{sup 13} from this plasma preparation stage alone, without going on to the proposed separately driven NM implosion of the main plasma chamber. Two-dimensional MED computational modeling of MAGO discharges shows good agreement to experiment. The calculations suggest that after the observed neutron pulse, a diffuse Z-pinch plasma with temperature in excess of 100 eV is created, which may be suitable for subsequent MTF implosion, in a heavy liner magnetically driven by explosive pulsed power. Other MTF concepts, such as fiber-initiated Z-pinch target plasmas, are also being computationally and theoretically evaluated. The status of our modeling efforts will be reported.

  2. Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.

    PubMed

    Ermolayev, Vladimir; Mohajerani, Pouyan; Ale, Angelique; Sarantopoulos, Athanasios; Aichler, Michaela; Kayser, Gian; Walch, Axel; Ntziachristos, Vasilis

    2015-09-01

    Non-small cell lung cancer is characterized by slow progression and high heterogeneity of tumors. Integrins play an important role in lung cancer development and metastasis and were suggested as a tumor marker; however their role in anticancer therapy remains controversial. In this work, we demonstrate the potential of integrin-targeted imaging to recognize early lesions in transgenic mouse model of lung cancer based on spontaneous introduction of mutated human gene bearing K-ras mutation. We conducted ex vivo and fluorescence molecular tomography-X-ray computed tomography (FMT-XCT) in vivo imaging and analysis for specific targeting of early lung lesions and tumors in rodent preclinical model for lung cancer. The lesions and tumors were characterized by histology, immunofluorescence and immunohistochemistry using a panel of cancer markers. Ex vivo, the integrin-targeted fluorescent signal significantly differed between wild type lung tissue and K-ras pulmonary lesions (PL) at all ages studied. The panel of immunofluorescence experiments demonstrated that PL, which only partially show cancer cell features were detected by αvβ3-integrin targeted imaging. Human patient material analysis confirmed the specificity of target localization in different lung cancer types. Most importantly, small tumors in the lungs of 4-week-old animals could be noninvasively detected in vivo on the fluorescence channel of FMT-XCT. Our findings demonstrated αvβ3-integrin targeted fluorescent imaging to specifically detect premalignant pleural lesions in K-ras mice. Integrin targeted imaging may find application areas in preclinical research and clinical practice, such as early lung cancer diagnostics, intraoperative assistance or therapy monitoring.

  3. Optimal Strategies for Controlling Riverine Tsetse Flies Using Targets: A Modelling Study

    PubMed Central

    Vale, Glyn A.; Hargrove, John W.; Lehane, Michael J.; Solano, Philippe; Torr, Stephen J.

    2015-01-01

    Background Tsetse flies occur in much of sub-Saharan Africa where they transmit the trypanosomes that cause the diseases of sleeping sickness in humans and nagana in livestock. One of the most economical and effective methods of tsetse control is the use of insecticide-treated screens, called targets, that simulate hosts. Targets have been ~1m2, but recently it was shown that those tsetse that occupy riverine situations, and which are the main vectors of sleeping sickness, respond well to targets only ~0.06m2. The cheapness of these tiny targets suggests the need to reconsider what intensity and duration of target deployments comprise the most cost-effective strategy in various riverine habitats. Methodology/Principal Findings A deterministic model, written in Excel spreadsheets and managed by Visual Basic for Applications, simulated the births, deaths and movement of tsetse confined to a strip of riverine vegetation composed of segments of habitat in which the tsetse population was either self-sustaining, or not sustainable unless supplemented by immigrants. Results suggested that in many situations the use of tiny targets at high density for just a few months per year would be the most cost-effective strategy for rapidly reducing tsetse densities by the ~90% expected to have a great impact on the incidence of sleeping sickness. Local elimination of tsetse becomes feasible when targets are deployed in isolated situations, or where the only invasion occurs from populations that are not self-sustaining. Conclusion/Significance Seasonal use of tiny targets deserves field trials. The ability to recognise habitat that contains tsetse populations which are not self-sustaining could improve the planning of all methods of tsetse control, against any species, in riverine, savannah or forest situations. Criteria to assist such recognition are suggested. PMID:25803871

  4. Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model.

    PubMed

    Lepak, Alexander J; Marchillo, Karen; VanHecker, Jamie; Diekema, Daniel; Andes, David R

    2013-11-01

    Pharmacodynamic (PD) studies with triazoles in the neutropenic murine disseminated candidiasis model have been performed extensively for Candida albicans. They have consistently shown that the pharmacodynamic index most closely correlated with efficacy is the ratio of the 24-h area under the concentration-time curve (AUC) to the MIC, and a target 24-h free-drug AUC/MIC ratio near 25 is associated with 50% of maximal microbiologic efficacy. We utilized this model to investigate the pharmacodynamics of isavuconazole. Isavuconazole pharmacokinetics were linear over the dose range studied. Oral-gastric doses of 640, 160, 40, and 10 mg of prodrug/kg of body weight produced peak levels of 0.51 to 25.4 mg/liter, an elimination half-life of 1 to 5 h, and an AUC from 0 h to infinity (AUC0-∞) of 0.9 to 287 mg · h/liter. The AUC/MIC ratio was the pharmacodynamic index that correlated best with efficacy (R(2), 0.84). Pharmacodynamic target studies were performed using 4 C. albicans isolates with both a 24-h and a 96-h treatment duration. The strains were chosen to include previously characterized fluconazole-resistant strains. The mean 50% effective doses (ED50) (expressed in mg/kg of body weight/12 h) and associated 24-h free-drug AUC/MIC ratios were 89.3 ± 46.7 and 67.7 ± 35 for the 24-h treatment and 59.6 ± 22 and 33.3 ± 25.5 for the 96-h treatment. These differences were not statistically significant. Pharmacodynamic targets for two non-albicans Candida species were also explored. The mean ED50 (expressed in mg/kg/12 h) and associated 24-h free-drug AUC/MIC ratios were 31.2 and 6.2 for Candida tropicalis (n = 1) and 50.5 and 1.6 for Candida glabrata (n = 2). These PD targets were significantly different from C. albicans targets (P, 0.04). Isavuconazole PD targets for C. albicans are similar to those observed in this model with other triazoles. However, the PD targets for non-albicans Candida species were more than 10-fold lower than those for C. albicans (P, 0

  5. Analytical model for interaction of short intense laser pulse with solid target

    SciTech Connect

    Luan, S. X.; Ma, G. J.; Yu, Wei; Yu, M. Y.; Zhang, Q. J.; Sheng, Z. M.; Murakami, M.

    2011-04-15

    A simple but comprehensive two-dimensional analytical model for the interaction of a normally incident short intense laser pulse with a solid-density plasma is proposed. Electron cavitation near the target surface by the laser ponderomotive force induces a strong local electrostatic charge-separation field. The cavitation makes possible mode conversion of the laser light into longitudinal electron oscillation at laser frequency, even for initial normal incidence of laser pulse. The intense charge-separation field in the cavity can significantly enhance the laser induced uxB electron oscillation at twice laser frequency to density levels even higher than that of the initial target.

  6. A Production System Model of Capturing Reactive Moving Targets. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Jagacinski, R. J.; Plamondon, B. D.; Miller, R. A.

    1984-01-01

    Subjects manipulated a control stick to position a cursor over a moving target that reacted with a computer-generated escape strategy. The cursor movements were described at two levels of abstraction. At the upper level, a production system described transitions among four modes of activity; rapid acquisition, close following, a predictive mode, and herding. Within each mode, differential equations described trajectory-generating mechanisms. A simulation of this two-level model captures the targets in a manner resembling the episodic time histories of human subjects.

  7. Photon parton distributions in nuclei and the EMC effect

    SciTech Connect

    Frankfurt, L.; Strikman, M.

    2010-12-15

    Photons, as well as quarks and gluons, are constituents of the infinite momentum frame (IMF) wave function of an energetic particle. They are mostly equivalent photons whose amplitude follows from the Lorentz transformation of the particle rest frame Coulomb field into the IMF and from the conservation of the electromagnetic current. We evaluate in a model independent way the dominant photon contribution {proportional_to}{alpha}{sub em}(Z{sup 2}/A{sup 4/3})ln(1/R{sub A}m{sub N}x) to the nuclear structure functions as well as the term {proportional_to}{alpha}{sub em}Z/A. In addition we show that the definition of x consistent with the exact kinematics of eA scattering (with exact sum rules) works in the same direction as the nucleus field of equivalent photons. Combined, these effects account for the bulk of the hadronic European Muon Collaboration (EMC) effect for x{<=}0.5 where Fermi motion effects are small. In particular, for these x the hadronic mechanism contribution to the EMC effect does not exceed {approx}3% for all nuclei. Also, the A dependence of the hadronic mechanism of the EMC effect for x>0.5 is significantly modified.

  8. Photon parton distributions in nuclei and the EMC effect

    SciTech Connect

    Frankfurt, Leonid; Strikman, Mark

    2010-12-01

    Photons as well as quarks and gluons are constituents of the infinite momentum frame (IMF) wave function of an energetic particle. They are mostly equivalent photons whose amplitude follows from the Lorentz transformation of the particle rest frame Coulomb field into the IMF and from the conservation of the electromagnetic current. We evaluate in a model independent way the dominant photon contribution \\propto \\alpha_{em}(Z^2/A^{4/3})\\ln(1/R_{A}m_{N}x) to the nuclear structure functions as well as the term \\propto \\alpha_{em}Z/A. In addition we show that the definition of x consistent with the exact kinematics of eA scattering (with exact sum rules) works in the same direction as the nucleus field of equivalent photons. Combined, these effects account for the bulk of the EMC effect for x\\le 0.5 where Fermi motion effects are small. In particular for these x the hadronic mechanism contribution to the EMC effect does not exceed \\sim 3% for all nuclei. Also the A-dependence of the hadronic mechanism of the EMC effect for x > 0.5 is significantly modified.

  9. A stochastic model for eye movements during fixation on a stationary target.

    NASA Technical Reports Server (NTRS)

    Vasudevan, R.; Phatak, A. V.; Smith, J. D.

    1971-01-01

    A stochastic model describing small eye movements occurring during steady fixation on a stationary target is presented. Based on eye movement data for steady gaze, the model has a hierarchical structure; the principal level represents the random motion of the image point within a local area of fixation, while the higher level mimics the jump processes involved in transitions from one local area to another. Target image motion within a local area is described by a Langevin-like stochastic differential equation taking into consideration the microsaccadic jumps pictured as being due to point processes and the high frequency muscle tremor, represented as a white noise. The transform of the probability density function for local area motion is obtained, leading to explicit expressions for their means and moments. Evaluation of these moments based on the model is comparable with experimental results.

  10. Modeling and production of 240Am by deuteron-induced activation of a 240Pu target

    SciTech Connect

    Finn, Erin C.; McNamara, Bruce K.; Greenwood, Lawrence R.; Wittman, Richard S.; Soderquist, Chuck Z.; Woods, Vincent T.; VanDevender, Brent A.; Metz, Lori A.; Friese, Judah I.

    2015-02-01

    A novel reaction pathway for production of 240Am is reported. Models of reaction cross-sections in EMPIRE II suggests that deuteron-induced activation of a 240Pu target produces maximum yields of 240Am from 11.5 MeV incident deuterons. This activation had not been previously reported in the literature. A 240Pu target was activated under the modeled optimum conditions to produce 240Am. The modeled cross-section for the 240Pu(d, 2n)240Am reaction is on the order of 20-30 mbarn, but the experimentally estimated value is 5.3 ± 0.2 mbarn. We discuss reasons for the discrepancy as well as production of other Am isotopes that contaminate the final product.

  11. Targeting CYP51 for drug design by the contributions of molecular modeling.

    PubMed

    Rabelo, Vitor W; Santos, Taísa F; Terra, Luciana; Santana, Marcos V; Castro, Helena C; Rodrigues, Carlos R; Abreu, Paula A

    2017-02-01

    CYP51 is an enzyme of sterol biosynthesis pathway present in animals, plants, protozoa and fungi. This enzyme is described as an important drug target that is still of interest. Therefore, in this work, we reviewed the structure and function of CYP51 and explored the molecular modeling approaches for the development of new antifungal and antiprotozoans that target this enzyme. Crystallographic structures of CYP51 of some organisms have already been described in the literature, which enable the construction of homology models of other organisms' enzymes and molecular docking studies of new ligands. The binding mode and interactions of some new series of azoles with antifungal or antiprotozoan activities has been studied and showed important residues of the active site. Molecular modeling is an important tool to be explored for the discovery and optimization of CYP51 inhibitors with better activities, pharmacokinetics, and toxicological profiles.

  12. Physiologically-based Pharmacokinetic Modeling of Target-Mediated Drug Disposition of Bortezomib in Mice

    PubMed Central

    Zhang, Li; Mager, Donald E.

    2015-01-01

    Bortezomib is a reversible proteasome inhibitor with potent antineoplastic activity that exhibits dose- and time-dependent pharmacokinetics (PK). Proteasome-mediated bortezomib disposition is proposed as the primary source of its nonlinear and apparent nonstationary PK behavior. Single intravenous (IV) doses of bortezomib (0.25 and 1 mg/kg) were administrated to BALB/c mice, with blood and tissue samples obtained over 144 hours, which were analyzed by LC/MS/MS. A physiologically based pharmacokinetic (PBPK) model incorporating tissue drug-target binding was developed to test the hypothesis of proteasome-mediated bortezomib disposition. The final model reasonably captured bortezomib plasma and tissue PK profiles, and parameters were estimated with good precision. The rank-order of model estimated tissue target density correlated well with experimentally measured proteasome concentrations reported in the literature, supporting the hypothesis that binding to proteasome influences bortezomib disposition. The PBPK model was further scaled-up to humans to assess the similarity of bortezomib disposition among species. Human plasma bortezomib PK profiles following multiple IV dosing (1.3 mg/m2) on days 1, 4, 8, and 11 were simulated by appropriately scaling estimated mouse parameters. Simulated and observed bortezomib concentrations after multiple dosing were in good agreement, suggesting target-mediated bortezomib disposition is likely for both mice and humans. Furthermore, the model predicts that renal impairment should exert minimal influence on bortezomib exposure in humans, confirming that bortezomib dose adjustment is not necessary for patients with renal impairment. PMID:26391023

  13. A Canopy Density Model for Planar Orchard Target Detection Based on Ultrasonic Sensors

    PubMed Central

    Li, Hanzhe; Zhai, Changyuan; Weckler, Paul; Wang, Ning; Yang, Shuo; Zhang, Bo

    2016-01-01

    Orchard target-oriented variable rate spraying is an effective method to reduce pesticide drift and excessive residues. To accomplish this task, the orchard targets’ characteristic information is needed to control liquid flow rate and airflow rate. One of the most important characteristics is the canopy density. In order to establish the canopy density model for a planar orchard target which is indispensable for canopy density calculation, a target density detection testing system was developed based on an ultrasonic sensor. A time-domain energy analysis method was employed to analyze the ultrasonic signal. Orthogonal regression central composite experiments were designed and conducted using man-made canopies of known density with three or four layers of leaves. Two model equations were obtained, of which the model for the canopies with four layers was found to be the most reliable. A verification test was conducted with different layers at the same density values and detecting distances. The test results showed that the relative errors of model density values and actual values of five, four, three and two layers of leaves were acceptable, while the maximum relative errors were 17.68%, 25.64%, 21.33% and 29.92%, respectively. It also suggested the model equation with four layers had a good applicability with different layers which increased with adjacent layers. PMID:28029132

  14. Efficacy of targeted AKT inhibition in genetically engineered mouse models of PTEN-deficient prostate cancer.

    PubMed

    De Velasco, Marco A; Kura, Yurie; Yoshikawa, Kazuhiro; Nishio, Kazuto; Davies, Barry R; Uemura, Hirotsugu

    2016-03-29

    The PI3K/AKT pathway is frequently altered in advanced human prostate cancer mainly through the loss of functional PTEN, and presents as potential target for personalized therapy. Our aim was to determine the therapeutic potential of the pan-AKT inhibitor, AZD5363, in PTEN-deficient prostate cancer. Here we used a genetically engineered mouse (GEM) model of PTEN-deficient prostate cancer to evaluate the in vivo pharmacodynamic and antitumor activity of AZD5363 in castration-naïve and castration-resistant prostate cancer. An additional GEM model, based on the concomitant inactivation of PTEN and Trp53 (P53), was established as an aggressive model of advanced prostate cancer and was used to further evaluate clinically relevant endpoints after treatment with AZD5363. In vivo pharmacodynamic studies demonstrated that AZD5363 effectively inhibited downstream targets of AKT. AZD5363 monotherapy significantly reduced growth of tumors in castration-naïve and castration-resistant models of PTEN-deficient prostate cancer. More importantly, AZD5363 significantly delayed tumor growth and improved overall survival and progression-free survival in PTEN/P53 double knockout mice. Our findings demonstrate that AZD5363 is effective against GEM models of PTEN-deficient prostate cancer and provide lines of evidence to support further investigation into the development of treatment strategies targeting AKT for the treatment of PTEN-deficient prostate cancer.

  15. Biodistribution of antibody-targeted and non-targeted iron oxide nanoparticles in a breast cancer mouse model

    NASA Astrophysics Data System (ADS)

    Tate, Jennifer A.; Kett, Warren; NDong, Christian; Griswold, Karl E.; Hoopes, P. Jack

    2013-02-01

    Iron oxide nanoparticle (IONP) hyperthermia is a novel therapeutic strategy currently under consideration for the treatment of various cancer types. Systemic delivery of IONP followed by non-invasive activation via a local alternating magnetic field (AMF) results in site-specific energy deposition in the IONP-containing tumor. Targeting IONP to the tumor using an antibody or antibody fragment conjugated to the surface may enhance the intratumoral deposition of IONP and is currently being pursued by many nanoparticle researchers. This strategy, however, is subject to a variety of restrictions in the in vivo environment, where other aspects of IONP design will strongly influence the biodistribution. In these studies, various targeted IONP are compared to non-targeted controls. IONP were injected into BT-474 tumor-bearing NSG mice and tissues harvested 24hrs post-injection. Results indicate no significant difference between the various targeted IONP and the non-targeted controls, suggesting the IONP were prohibitively-sized to incur tumor penetration. Additional strategies are currently being pursued in conjuncture with targeted particles to increase the intratumoral deposition.

  16. Serial diffusion MRI to monitor and model treatment response of the targeted nanotherapy CRLX101

    PubMed Central

    Ng, Thomas S.C.; Wert, David; Sohi, Hargun; Procissi, Daniel; Colcher, David; Raubitschek, Andrew A.; Jacobs, Russell E.

    2013-01-01

    Purpose Targeted nanotherapies are being developed to improve tumor drug delivery and enhance therapeutic response. Techniques that can predict response will facilitate clinical translation and may help define optimal treatment strategies. We evaluated the efficacy of diffusion-weighted magnetic resonance imaging to monitor early response to CRLX101 nanotherapy (formerly IT-101), and explored its potential as a therapeutic response predictor using a mechanistic model of tumor cell-proliferation. Experimental Design Diffusion MRI was serially performed following CRLX101 administration in a mouse lymphoma model. Apparent diffusion coefficients (ADC) extracted from the data were used as treatment response biomarkers. Animals treated with irinotecan (CPT-11) and saline were imaged for comparison. ADC data were also input into a mathematical model of tumor growth. Histological analysis using cleaved-caspase 3, TUNEL, Ki-67 and H&E were conducted on tumor samples for correlation with imaging results. Results CRLX101 treated tumors at day 2, 4, 7 post-treatment exhibited changes in mean ADC=16 ± 9%, 24 ± 10% 49 ± 17% and size (TV)=−5 ± 3%, −30 ± 4% and −45 ± 13% respectively. Both parameters were statistically greater than controls (p(ADC) ≤ 0.02, and p(TV) ≤ 0.01 at day 4 and 7), and noticeably greater than CPT-11 treated tumors (ADC=5 ± 5%, 14 ± 7% and 18 ± 6%, TV=−15 ± 5%, −22 ± 13% and −26 ± 8%). Model-derived parameters for cell-proliferation obtained using ADC data distinguished CRLX101 treated tumors from controls (p = 0.02). Conclusions Temporal changes in ADC specified early CRLX101 treatment response and could be used to model image-derived cell-proliferation rates following treatment. Comparisons of targeted and non-targeted treatments highlight the utility of non-invasive imaging and modeling to evaluate, monitor and predict responses to targeted nanotherapeutics. PMID:23532891

  17. Statistical modeling of targets and clutter in single-look non-polarimetric SAR imagery

    SciTech Connect

    Salazar, J.S.; Hush, D.R.; Koch, M.W.; Fogler, R.J.; Hostetler, L.D.

    1998-08-01

    This paper presents a Generalized Logistic (gLG) distribution as a unified model for Log-domain synthetic aperture Radar (SAR) data. This model stems from a special case of the G-distribution known as the G{sup 0}-distribution. The G-distribution arises from a multiplicative SAR model and has the classical K-distribution as another special case. The G{sup 0}-distribution, however, can model extremely heterogeneous clutter regions that the k-distribution cannot model. This flexibility is preserved in the unified gLG model, which is capable of modeling non-polarimetric SAR returns from clutter as well as man-made objects. Histograms of these two types of SAR returns have opposite skewness. The flexibility of the gLG model lies in its shape and shift parameters. The shape parameter describes the differing skewness between target and clutter data while the shift parameter compensates for movements in the mean as the shape parameter changes. A Maximum Likelihood (ML) estimate of the shape parameter gives an optimal measure of the skewness of the SAR data. This measure provides a basis for an optimal target detection algorithm.

  18. Systems-level modeling of mycobacterial metabolism for the identification of new (multi-)drug targets.

    PubMed

    Rienksma, Rienk A; Suarez-Diez, Maria; Spina, Lucie; Schaap, Peter J; Martins dos Santos, Vitor A P

    2014-12-01

    Systems-level metabolic network reconstructions and the derived constraint-based (CB) mathematical models are efficient tools to explore bacterial metabolism. Approximately one-fourth of the Mycobacterium tuberculosis (Mtb) genome contains genes that encode proteins directly involved in its metabolism. These represent potential drug targets that can be systematically probed with CB models through the prediction of genes essential (or the combination thereof) for the pathogen to grow. However, gene essentiality depends on the growth conditions and, so far, no in vitro model precisely mimics the host at the different stages of mycobacterial infection, limiting model predictions. These limitations can be circumvented by combining expression data from in vivo samples with a validated CB model, creating an accurate description of pathogen metabolism in the host. To this end, we present here a thoroughly curated and extended genome-scale CB metabolic model of Mtb quantitatively validated using 13C measurements. We describe some of the efforts made in integrating CB models and high-throughput data to generate condition specific models, and we will discuss challenges ahead. This knowledge and the framework herein presented will enable to identify potential new drug targets, and will foster the development of optimal therapeutic strategies.

  19. Simulation of synthetic aperture imaging ladar (SAIL) for three-dimensional target model

    NASA Astrophysics Data System (ADS)

    Yi, Ning; Wu, Zhen-Sen

    2010-11-01

    In conventional imaging laser radar, the resolution of target is constrained by the diffraction-limited, which includes the beamwidth of the laser in the target plane and the telescope's aperture. Synthetic aperture imaging Ladar (SAIL) is an imaging technique which employs aperture synthesis with coherent laser radar, the resolution is determined by the total frequency spread of the source and is independent of range, so can achieve fine resolution in long range. Ray tracing is utilized here to obtain two-dimensional scattering properties from three-dimensional geometric model of actual target, and range-doppler algorithm is used for synthetic aperture process in laser image simulation. The results show that the SAIL can support better resolution.

  20. Unsupervised Spatial Event Detection in Targeted Domains with Applications to Civil Unrest Modeling

    PubMed Central

    Zhao, Liang; Chen, Feng; Dai, Jing; Hua, Ting; Lu, Chang-Tien; Ramakrishnan, Naren

    2014-01-01

    Twitter has become a popular data source as a surrogate for monitoring and detecting events. Targeted domains such as crime, election, and social unrest require the creation of algorithms capable of detecting events pertinent to these domains. Due to the unstructured language, short-length messages, dynamics, and heterogeneity typical of Twitter data streams, it is technically difficult and labor-intensive to develop and maintain supervised learning systems. We present a novel unsupervised approach for detecting spatial events in targeted domains and illustrate this approach using one specific domain, viz. civil unrest modeling. Given a targeted domain, we propose a dynamic query expansion algorithm to iteratively expand domain-related terms, and generate a tweet homogeneous graph. An anomaly identification method is utilized to detect spatial events over this graph by jointly maximizing local modularity and spatial scan statistics. Extensive experiments conducted in 10 Latin American countries demonstrate the effectiveness of the proposed approach. PMID:25350136

  1. Insights on non-perturbative aspects of TMDs from models

    SciTech Connect

    H. Avakian, A. Efremov, P. Schweitzer, O. Teryaev, F. Yuan, P. Zavada

    2009-12-01

    Transverse momentum dependent parton distribution functions are a key ingredient in the description of spin and azimuthal asymmetries in deep-inelastic scattering processes. Recent results from non-perturbative calculations in effective approaches are reviewed, with focus on relations among different parton distribution functions in QCD and models.

  2. Fast approximate EM induction modeling of metallic and UXO targets using a permeable prism

    NASA Astrophysics Data System (ADS)

    Asten, Michael W.; Duncan, Andrew C.

    2007-03-01

    The time-domain EM induction response of non-magnetic and magnetic targets can be approximated using a conductive permeable prism composed of six faces of conductive plates, each face being composed of a set of conductive ribbons. The effect of magnetic permeability is included by the use of two "apparent flux gathering" coefficients, and two "effective magnetic permeability" coefficients, in the axial and transverse directions. These four magnetic property coefficients are a function of physical properties and geometry of the target, but are independent of prism orientation relative to a transmitter. The approximation algorithm is computationally fast, allowing inversions for target parameters to be achieved in seconds. The model is tested on profiles acquired with a Geonics EM63 time-domain EM metal detector over a non-magnetic copper pipe target, and a steel artillery shell in horizontal and vertical orientations. Results show that this approximation to a permeable prism has a capability of fitting geometric, conductivity and magnetic parameters at both early and late sample times. The magnetic parameters show strong change from early to late times on the EMI decay curve, indicating that the magnetic properties of the target have non-linear characteristics. It is proposed that these magnetic parameters and the nature of their non-linearity may carry additional discrimination information for distinguishing between intact munitions and scrap in UXO studies.

  3. Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models.

    PubMed

    Céspedes, María Virtudes; Unzueta, Ugutz; Álamo, Patricia; Gallardo, Alberto; Sala, Rita; Casanova, Isolda; Pavón, Miguel Angel; Mangues, María Antonia; Trías, Manuel; López-Pousa, Antonio; Villaverde, Antonio; Vázquez, Esther; Mangues, Ramon

    2016-10-01

    Unliganded drug-nanoconjugates accumulate passively in the tumor whereas liganded nanoconjugates promote drug internalization in tumor cells via endocytosis and increase antitumor efficacy. Whether or not tumor cell internalization associates with enhanced tumor uptake is still under debate. We here compared tumor uptake of T22-GFP-H6, a liganded protein carrier targeting the CXCR4 receptor, and the unliganded GFP-H6 carrier in subcutaneous and metastatic colorectal cancer models. T22-GFP-H6 had a higher tumor uptake in primary tumor and metastatic foci than GFP-H6, with no biodistribution or toxicity on normal tissues. T22-GFP-H6 was detected in target CXCR4(+) tumor cell cytosol whereas GFP-H6 was detected in tumor stroma. SDF1-α co-administration switched T22-GFP-H6 internalization from CXCR4(+) tumor epithelial cells to the stroma. Therefore, the incorporation of a targeting ligand promotes selective accumulation of the nanocarrier inside target tumor cells while increasing whole tumor uptake in a CXCR4-dependent manner, validating T22-GFP-H6 as a CXCR4-targeted drug carrier.

  4. Dynamic magnetic resonance imaging assessment of vascular targeting agent effects in rat intracerebral tumor models.

    PubMed

    Muldoon, Leslie L; Gahramanov, Seymur; Li, Xin; Marshall, Deborah J; Kraemer, Dale F; Neuwelt, Edward A

    2011-01-01

    We used dynamic MRI to evaluate the effects of monoclonal antibodies targeting brain tumor vasculature. Female athymic rats with intracerebral human tumor xenografts were untreated or treated with intetumumab, targeting α(V)-integrins, or bevacizumab, targeting vascular endothelial growth factor (n = 4-6 per group). Prior to treatment and at 1, 3, and 7 days after treatment, we performed standard MRI to assess tumor volume, dynamic susceptibility-contrast MRI with the blood-pool iron oxide nanoparticle ferumoxytol to evaluate relative cerebral blood volume (rCBV), and dynamic contrast-enhanced MRI to assess tumor vascular permeability. Tumor rCBV increased by 27 ± 13% over 7 days in untreated rats; intetumumab increased tumor rCBV by 65 ± 10%, whereas bevacizumab reduced tumor rCBV by 31 ± 10% at 7 days (P < .001 for group and day). Similarly, intetumumab increased brain tumor vascular permeability compared with controls at 3 and 7 days after treatment, whereas bevacizumab decreased tumor permeability within 24 hours (P = .0004 for group, P = .0081 for day). All tumors grew over the 7-day assessment period, but bevacizumab slowed the increase in tumor volume on MRI. We conclude that the vascular targeting agents intetumumab and bevacizumab had diametrically opposite effects on dynamic MRI of tumor vasculature in rat brain tumor models. Targeting α(V)-integrins increased tumor vascular permeability and blood volume, whereas bevacizumab decreased both measures. These findings have implications for chemotherapy delivery and antitumor efficacy.

  5. [Passive ranging of infrared target using oxygen A-band and Elsasser model].

    PubMed

    Li, Jin-Hua; Wang, Zhao-Ba; Wang Zhi

    2014-09-01

    Passive ranging method of short range and single band was developed based on target radiation and attenuation characteristic of oxygen spectrum absorption. The relation between transmittance of oxygen A band and range of measured target was analyzed. Radiation strength distribution of measured target can be obtained according to the distribution law of absorption coefficient with environmental parameters. Passive ranging mathematical model of short ranges was established using Elsasser model with Lorentz line shape based on the computational methods of band average transmittance and high-temperature gas radiation narrowband model. The range of measured object was obtained using transmittance fitting with test data calculation and theoretical model. Besides, ranging precision was corrected considering the influence of oxygen absorption with enviromental parameter. The ranging experiment platform was established. The source was a 10 watt black body, and a grating spectrometer with 17 cm(-1) resolution was used. In order to improve the light receiving efficiency, light input was collected with 23 mm calibre telescope. The test data was processed for different range in 200 m. The results show that the transmittance accuracy was better than 2.18% in short range compared to the test data with predicted value in the same conditions.

  6. Live imaging and modeling of inner nuclear membrane targeting reveals its molecular requirements in mammalian cells

    PubMed Central

    Boni, Andrea; Politi, Antonio Z.; Strnad, Petr; Xiang, Wanqing; Hossain, M. Julius

    2015-01-01

    Targeting of inner nuclear membrane (INM) proteins is essential for nuclear architecture and function, yet its mechanism remains poorly understood. Here, we established a new reporter that allows real-time imaging of membrane protein transport from the ER to the INM using Lamin B receptor and Lap2β as model INM proteins. These reporters allowed us to characterize the kinetics of INM targeting and establish a mathematical model of this process and enabled us to probe its molecular requirements in an RNA interference screen of 96 candidate genes. Modeling of the phenotypes of genes involved in transport of these INM proteins predicted that it critically depended on the number and permeability of nuclear pores and the availability of nuclear binding sites, but was unaffected by depletion of most transport receptors. These predictions were confirmed with targeted validation experiments on the functional requirements of nucleoporins and nuclear lamins. Collectively, our data support a diffusion retention model of INM protein transport in mammalian cells. PMID:26056140

  7. Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing.

    PubMed

    Manes, Nathan P; Angermann, Bastian R; Koppenol-Raab, Marijke; An, Eunkyung; Sjoelund, Virginie H; Sun, Jing; Ishii, Masaru; Germain, Ronald N; Meier-Schellersheim, Martin; Nita-Lazar, Aleksandra

    2015-10-01

    Osteoclasts are monocyte-derived multinuclear cells that directly attach to and resorb bone. Sphingosine-1-phosphate (S1P)(1) regulates bone resorption by functioning as both a chemoattractant and chemorepellent of osteoclast precursors through two G-protein coupled receptors that antagonize each other in an S1P-concentration-dependent manner. To quantitatively explore the behavior of this chemosensing pathway, we applied targeted proteomics, transcriptomics, and rule-based pathway modeling using the Simmune toolset. RAW264.7 cells (a mouse monocyte/macrophage cell line) were used as model osteoclast precursors, RNA-seq was used to identify expressed target proteins, and selected reaction monitoring (SRM) mass spectrometry using internal peptide standards was used to perform absolute abundance measurements of pathway proteins. The resulting transcript and protein abundance values were strongly correlated. Measured protein abundance values, used as simulation input parameters, led to in silico pathway behavior matching in vitro measurements. Moreover, once model parameters were established, even simulated responses toward stimuli that were not used for parameterization were consistent with experimental findings. These findings demonstrate the feasibility and value of combining targeted mass spectrometry with pathway modeling for advancing biological insight.

  8. Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models.

    PubMed

    Osman, Erkan Y; Miller, Madeline R; Robbins, Kate L; Lombardi, Abby M; Atkinson, Arleigh K; Brehm, Amanda J; Lorson, Christian L

    2014-09-15

    Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of Survival Motor Neuron-1 (SMN1). In all SMA patients, a nearly identical copy gene called SMN2 is present, which produces low levels of functional protein owing to an alternative splicing event. To prevent exon-skipping, we have targeted an intronic repressor, Element1 (E1), located upstream of SMN2 exon 7 using Morpholino-based antisense oligonucleotides (E1(MO)-ASOs). A single intracerebroventricular injection in the relatively severe mouse model of SMA (SMNΔ7 mouse model) elicited a robust induction of SMN protein, and mean life span was extended from an average survival of 13 to 54 days following a single dose, consistent with large weight gains and a correction of the neuronal pathology. Additionally, E1(MO)-ASO treatment in an intermediate SMA mouse (SMN(RT) mouse model) significantly extended life span by ∼700% and weight gain was comparable with the unaffected animals. While a number of experimental therapeutics have targeted the ISS-N1 element of SMN2 pre-mRNA, the development of E1 ASOs provides a new molecular target for SMA therapeutics that dramatically extends survival in two important pre-clinical models of disease.

  9. Modeling of beam-target interaction during pulsed electron beam ablation of graphite: Case of melting

    NASA Astrophysics Data System (ADS)

    Ali, Muddassir; Henda, Redhouane

    2017-02-01

    A one-dimensional thermal model based on a two-stage heat conduction equation is employed to investigate the ablation of graphite target during nanosecond pulsed electron beam ablation. This comprehensive model accounts for the complex physical phenomena comprised of target heating, melting and vaporization upon irradiation with a polyenergetic electron beam. Melting and vaporization effects induced during ablation are taken into account by introducing moving phase boundaries. Phase transition induced during ablation is considered through the temperature dependent thermodynamic properties of graphite. The effect of electron beam efficiency, power density, and accelerating voltage on ablation is analyzed. For an electron beam operating at an accelerating voltage of 15 kV and efficiency of 0.6, the model findings show that the target surface temperature can reach up to 7500 K at the end of the pulse. The surface begins to melt within 25 ns from the pulse start. For the same process conditions, the estimated ablation depth and ablated mass per unit area are about 0.60 μm and 1.05 μg/mm2, respectively. Model results indicate that ablation takes place primarily in the regime of normal vaporization from the surface. The results obtained at an accelerating voltage of 15 kV and efficiency factor of 0.6 are satisfactorily in good accordance with available experimental data in the literature.

  10. Laser induced plasma on copper target, a non-equilibrium model

    SciTech Connect

    Oumeziane, Amina Ait Liani, Bachir; Parisse, Jean-Denis

    2014-02-15

    The aim of this work is to present a comprehensive numerical model for the UV laser ablation of metal targets, it focuses mainly on the prediction of laser induced plasma thresholds, the effect of the laser-plasma interaction, and the importance of the electronic non-equilibrium in the laser induced plume and its expansion in the background gas. This paper describes a set of numerical models for laser-matter interaction between 193-248 and 355 nm lasers and a copper target. Along with the thermal effects inside the material resulting from the irradiation of the latter with the pulsed laser, the laser-evaporated matter interaction and the plasma formation are thoroughly modelled. In the laser induced plume, the electronic nonequilibrium and the laser beam absorption have been investigated. Our calculations of the plasmas ignition thresholds on copper targets have been validated and compared to experimental as well as theoretical results. Comparison with experiment data indicates that our results are in good agreement with those reported in the literature. Furthermore, the inclusion of electronic non-equilibrium in our work indicated that this important process must be included in models of laser ablation and plasma plume formation.

  11. Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing*

    PubMed Central

    Manes, Nathan P.; Angermann, Bastian R.; Koppenol-Raab, Marijke; An, Eunkyung; Sjoelund, Virginie H.; Sun, Jing; Ishii, Masaru; Germain, Ronald N.; Meier-Schellersheim, Martin; Nita-Lazar, Aleksandra

    2015-01-01

    Osteoclasts are monocyte-derived multinuclear cells that directly attach to and resorb bone. Sphingosine-1-phosphate (S1P)1 regulates bone resorption by functioning as both a chemoattractant and chemorepellent of osteoclast precursors through two G-protein coupled receptors that antagonize each other in an S1P-concentration-dependent manner. To quantitatively explore the behavior of this chemosensing pathway, we applied targeted proteomics, transcriptomics, and rule-based pathway modeling using the Simmune toolset. RAW264.7 cells (a mouse monocyte/macrophage cell line) were used as model osteoclast precursors, RNA-seq was used to identify expressed target proteins, and selected reaction monitoring (SRM) mass spectrometry using internal peptide standards was used to perform absolute abundance measurements of pathway proteins. The resulting transcript and protein abundance values were strongly correlated. Measured protein abundance values, used as simulation input parameters, led to in silico pathway behavior matching in vitro measurements. Moreover, once model parameters were established, even simulated responses toward stimuli that were not used for parameterization were consistent with experimental findings. These findings demonstrate the feasibility and value of combining targeted mass spectrometry with pathway modeling for advancing biological insight. PMID:26199343

  12. Study of a dense, coronal thick target source with the microwave data and 3D modeling

    NASA Astrophysics Data System (ADS)

    Fleishman, Gregory; Xu, Yan

    2015-04-01

    We present a detailed 3D modeling of a dense, coronal thick target X-ray flare using the GX Simulator tool, photospheric magnetic measurements, and microwave data. The developed model offers a remarkable agreement between the synthesized and observed spectra and images in both X-ray and microwave domains, which validates the entire model. The flaring loop parameters validated via the modeling are fully consistent with those derived from the X-ray spectral fit, but do not easily agree with those derived from the fit of the X-ray image sizes computed at various energies. Specifically, the plasma density obtained in the modeling is noticeably smaller than that derived from the size fit. The performed modeling suggests that the accelerated electrons are trapped at the coronal part of the flaring loop by a turbulence, while proves that the data are clearly inconsistent with the electron magnetic trapping in the weak diffusion regime mediated by the Coulomb collisions. Thus, the modeling confirms the interpretation of the coronal thick-target sources as the sites of electron acceleration in flares.This work was supported in part by NSF grants AGS-1250374, AGS-1262772, AGS-1153424, AGS-1348513, and AGS-1408703 and NASA grants NNX14AC87G and NNX-13AG13G to New Jersey Institute of Technology.

  13. Oculo-manual tracking of visual targets: control learning, coordination control and coordination model.

    PubMed

    Gauthier, G M; Vercher, J L; Mussa Ivaldi, F; Marchetti, E

    1988-01-01

    The processes which develop to coordinate eye and hand movements in response to motion of a visual target were studied in young children and adults. We have shown that functional maturation of the coordination control between eye and hand takes place as a result of training. We observed, in the trained child and in the adult, that when the hand is used either as a target or to track a visual target, the dynamic characteristics of the smooth pursuit system are markedly improved: the eye to target delay is decreased from 150 ms in eye alone tracking to 30 ms, and smooth pursuit maximum velocity is increased by 100%. Coordination signals between arm and eye motor systems may be responsible for smooth pursuit eye movements which occur during self-tracking of hand or finger in darkness. These signals may also account for the higher velocity smooth pursuit eye movements and the shortened tracking delay when the hand is used as a target, as well as for the synkinetic eye-arm motions observed at the early stage of oculo-manual tracking training in children. We propose a model to describe the interaction which develops between two systems involved in the execution of a common sensorimotor task. The model applies to the visuo-oculo-manual tracking system, but it may be generalized to other coordinated systems. According to our definition, coordination control results from the reciprocal transfer of sensory and motor information between two or more systems involved in the execution of single, goal-directed or conjugate actions. This control, originating in one or more highly specialized structures of the central nervous system, combines with the control processes normally operating in each system. Our model relies on two essential notions which describe the dynamic and static aspects of coordination control: timing and mutual coupling.

  14. The Generalized Parton Distribution program in Hall A at Jefferson Lab

    SciTech Connect

    Camacho, C. Munoz

    2008-10-13

    Recent results on the Generalized Parton Distribution (GPD) program at Jefferson Lab (JLab) will be presented. The emphasis will be in the Hall A program aiming at measuring Q{sup 2}--dependences of different terms of the Deeply Virtual Compton Scattering (DVCS) cross section. This is a fundamental step before one can extract GPD information from JLab DVCS data. Neutral pion production will also be discussed and results from the CLAS collaboration will be shown. Finally, the upcoming program in Hall A, using both a 6 GeV beam ({approx_equal}2010) and a 11 GeV beam ({approx_equal}2015) will be described.

  15. Anomalous coupling, top-mass and parton-shower effects in W + W - production

    NASA Astrophysics Data System (ADS)

    Bellm, J.; Gieseke, S.; Greiner, N.; Heinrich, G.; Plätzer, S.; Reuschle, C.; von Soden-Fraunhofen, J. F.

    2016-05-01

    We calculate the process ppto {W}+{W}-to {e}+{ν}_e{μ}-{overline{ν}}_{μ } at NLO QCD, including also effective field theory (EFT) operators mediating the ggW + W - interaction, which first occur at dimension eight. We further combine the NLO and EFT matrix elements produced by G oS am with the H erwig7/M atchbox framework, which offers the possibility to study the impact of a parton shower. We assess the effects of the anomalous couplings by comparing them to top-mass effects as well as uncertainties related to variations of the renormalisation, factorisation and hard shower scales.

  16. Hadron production in deuteron-gold collisions and nuclear parton distributions

    SciTech Connect

    Adeluyi, Adeola; Fai, George

    2007-11-15

    We calculate nuclear modification factors R{sub dAu}, central-to-peripheral ratios, R{sub CP}, and pseudorapidity asymmetries Y{sub Asym} in deuteron-gold collisions at {radical}(s)=200 GeV in the framework of leading-order (LO) perturbative quantum chromodynamics. We use the Eskola-Kolhinen-Salgado (EKS), the Frankfurt-Guzey-Strikman (FGS), and the Hirai-Kumano-Nagai (HKN) nuclear parton distribution functions and the Albino-Kramer-Kniehl (AKK) fragmentation functions in our calculations. Results are compared to experimental data from the BRAHMS and STAR collaborations.

  17. Hadron production in deuteron-gold collisions and nuclear parton distributions

    NASA Astrophysics Data System (ADS)

    Adeluyi, Adeola; Fai, George

    2007-11-01

    We calculate nuclear modification factors RdAu, central-to-peripheral ratios, RCP, and pseudorapidity asymmetries YAsym in deuteron-gold collisions at s=200 GeV in the framework of leading-order (LO) perturbative quantum chromodynamics. We use the Eskola-Kolhinen-Salgado (EKS), the Frankfurt-Guzey-Strikman (FGS), and the Hirai-Kumano-Nagai (HKN) nuclear parton distribution functions and the Albino-Kramer-Kniehl (AKK) fragmentation functions in our calculations. Results are compared to experimental data from the BRAHMS and STAR collaborations.

  18. QCD CORRECTIONS TO DILEPTON PRODUCTION NEAR PARTONIC THRESHOLD IN PP SCATTERING.

    SciTech Connect

    SHIMIZU, H.; STERMAN, G.; VOGELSANG, W.; YOKOYA, H.

    2005-10-02

    We present a recent study of the QCD corrections to dilepton production near partonic threshold in transversely polarized {bar p}p scattering, We analyze the role of the higher-order perturbative QCD corrections in terms of the available fixed-order contributions as well as of all-order soft-gluon resummations for the kinematical regime of proposed experiments at GSI-FAIR. We find that perturbative corrections are large for both unpolarized and polarized cross sections, but that the spin asymmetries are stable. The role of the far infrared region of the momentum integral in the resummed exponent and the effect of the NNLL resummation are briefly discussed.

  19. Double parton interactions as a background to associated HW production at the Tevatron

    SciTech Connect

    Bandurin, Dmitry; Golovanov, Georgy; Skachkov, Nikolai

    2010-11-01

    In this paper we study events with W+jets final state, produced in double parton (DP) interactions, as a background to the associated Higgs boson (H) and W production, with H {yields} b{bar b} decay, at the Tevatron. We have found that the event yield from the DP background can be quite sizable, what necessitates a choice of selection criteria to separate the HW and DP production processes. We suggest a set of variables sensitive to the kinematics of DP and HW events. We show that these variables, being used as an input to the artificial neural network, allow one to significantly improve a sensitivity to the Higgs boson production.

  20. APFEL Web: a web-based application for the graphical visualization of parton distribution functions

    NASA Astrophysics Data System (ADS)

    Carrazza, Stefano; Ferrara, Alfio; Palazzo, Daniele; Rojo, Juan

    2015-05-01

    We present APFEL Web, a Web-based application designed to provide a flexible user-friendly tool for the graphical visualization of parton distribution functions. In this note we describe the technical design of the APFEL Web application, motivating the choices and the framework used for the development of this project. We document the basic usage of APFEL Web and show how it can be used to provide useful input for a variety of collider phenomenological studies. Finally we provide some examples showing the output generated by the application.

  1. Development of an In Vitro Model to Screen CYP1B1-Targeted Anticancer Prodrugs.

    PubMed

    Wang, Zhiying; Chen, Yao; Drbohlav, Laura M; Wu, Judy Qiju; Wang, Michael Zhuo

    2016-12-01

    Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone-related cancers. One anticancer drug discovery strategy is to develop prodrugs specifically activated by CYP1B1 in malignant tissues to cytotoxic metabolites. Here, we aimed to develop an in vitro screening model for CYP1B1-targeted anticancer prodrugs using the KLE human endometrial carcinoma cell line. KLE cells demonstrated superior stability of CYP1B1 expression relative to transiently transfected cells and did not express any appreciable amount of cognate CYP1A1 or CYP1A2, which would have compromised the specificity of the screening assay. The effect of two CYP1B1-targeted probe prodrugs on KLE cells was evaluated in the absence and presence of a CYP1B1 inhibitor to chemically "knock out" CYP1B1 activity (CYP1B1 inhibited). Both probe prodrugs were more toxic to KLE cells than to CYP1B1-inhibited KLE cells and significantly induced G0/G1 arrest and decreased the S phase in KLE cells. They also exhibited pro-apoptotic effects in KLE cells, which were attenuated in CYP1B1-inhibited KLE cells. In summary, a KLE cell-based model has been characterized to be suitable for identifying CYP1B1-targeted anticancer prodrugs and should be further developed and employed for screening chemical libraries.

  2. Molecular Inversion Probes for targeted resequencing in non-model organisms

    PubMed Central

    Niedzicka, M.; Fijarczyk, A.; Dudek, K.; Stuglik, M.; Babik, W.

    2016-01-01

    Applications that require resequencing of hundreds or thousands of predefined genomic regions in numerous samples are common in studies of non-model organisms. However few approaches at the scale intermediate between multiplex PCR and sequence capture methods are available. Here we explored the utility of Molecular Inversion Probes (MIPs) for the medium-scale targeted resequencing in a non-model system. Markers targeting 112 bp of exonic sequence were designed from transcriptome of Lissotriton newts. We assessed performance of 248 MIP markers in a sample of 85 individuals. Among the 234 (94.4%) successfully amplified markers 80% had median coverage within one order of magnitude, indicating relatively uniform performance; coverage uniformity across individuals was also high. In the analysis of polymorphism and segregation within family, 77% of 248 tested MIPs were confirmed as single copy Mendelian markers. Genotyping concordance assessed using replicate samples exceeded 99%. MIP markers for targeted resequencing have a number of advantages: high specificity, high multiplexing level, low sample requirement, straightforward laboratory protocol, no need for preparation of genomic libraries and no ascertainment bias. We conclude that MIP markers provide an effective solution for resequencing targets of tens or hundreds of kb in any organism and in a large number of samples. PMID:27046329

  3. Targeted skipping of human dystrophin exons in transgenic mouse model systemically for antisense drug development.

    PubMed

    Wu, Bo; Benrashid, Ehsan; Lu, Peijuan; Cloer, Caryn; Zillmer, Allen; Shaban, Mona; Lu, Qi Long

    2011-01-01

    Antisense therapy has recently been demonstrated with great potential for targeted exon skipping and restoration of dystrophin production in cultured muscle cells and in muscles of Duchenne Muscular Dystrophy (DMD) patients. Therapeutic values of exon skipping critically depend on efficacy of the drugs, antisense oligomers (AOs). However, no animal model has been established to test AO targeting human dystrophin exon in vivo systemically. In this study, we applied Vivo-Morpholino to the hDMD mouse, a transgenic model carrying the full-length human dystrophin gene, and achieved for the first time more than 70% efficiency of targeted human dystrophin exon skipping in vivo systemically. We also established a GFP-reporter myoblast culture to screen AOs targeting human dystrophin exon 50. Antisense efficiency for most AOs is consistent between the reporter cells, human myoblasts and in the hDMD mice in vivo. However, variation in efficiency was also clearly observed. A combination of in vitro cell culture and a Vivo-Morpholino based evaluation in vivo systemically in the hDMD mice therefore may represent a prudent approach for selecting AO drug and to meet the regulatory requirement.

  4. Vapor shielding models and the energy absorbed by divertor targets during transient events

    SciTech Connect

    Skovorodin, D. I. Arakcheev, A. S.; Pshenov, A. A.; Eksaeva, E. A.; Marenkov, E. D.; Krasheninnikov, S. I.

    2016-02-15

    The erosion of divertor targets caused by high heat fluxes during transients is a serious threat to ITER operation, as it is going to be the main factor determining the divertor lifetime. Under the influence of extreme heat fluxes, the surface temperature of plasma facing components can reach some certain threshold, leading to an onset of intense material evaporation. The latter results in formation of cold dense vapor and secondary plasma cloud. This layer effectively absorbs the energy of the incident plasma flow, turning it into its own kinetic and internal energy and radiating it. This so called vapor shielding is a phenomenon that may help mitigating the erosion during transient events. In particular, the vapor shielding results in saturation of energy (per unit surface area) accumulated by the target during single pulse of heat load at some level E{sub max}. Matching this value is one of the possible tests to verify complicated numerical codes, developed to calculate the erosion rate during abnormal events in tokamaks. The paper presents three very different models of vapor shielding, demonstrating that E{sub max} depends strongly on the heat pulse duration, thermodynamic properties, and evaporation energy of the irradiated target material. While its dependence on the other shielding details such as radiation capabilities of material and dynamics of the vapor cloud is logarithmically weak. The reason for this is a strong (exponential) dependence of the target material evaporation rate, and therefore the “strength” of vapor shield on the target surface temperature. As a result, the influence of the vapor shielding phenomena details, such as radiation transport in the vapor cloud and evaporated material dynamics, on the E{sub max} is virtually completely masked by the strong dependence of the evaporation rate on the target surface temperature. However, the very same details define the amount of evaporated particles, needed to provide an effective shielding

  5. Folate Receptor-Targeted Multimodality Imaging of Ovarian Cancer in a Novel Syngeneic Mouse Model

    PubMed Central

    2015-01-01

    A new transplantable ovarian tumor model is presented using a novel folate receptor (FR) positive, murine ovarian cancer cell line that emulates the human disease and induces widespread intraperitoneal (i.p.) tumors in immunocompetent mice within 4–8 weeks of implantation. Tumor development was monitored using a new positron emission tomography (PET) FR-targeting reporter with PET/computerized tomography (PET/CT) and fluorescence molecular tomography (FMT) using a commercial FR-targeting reporter. Conventional structural magnetic resonance imaging (MRI) was also performed. Adult female C57BL/6 mice were injected i.p. with 6 × 106 MKP-L FR+ cells. Imaging was performed weekly beginning 2 weeks after tumor induction. The albumin-binding, FR-targeting ligand cm09 was radiolabeled with the positron emitter 68Ga and used to image the tumors with a small animal PET/CT. The FR-reporter FolateRSense 680 (PerkinElmer) was used for FMT and flow cytometry. Preclinical MRI (7 T) without FR-targeting was compared with the PET and FMT molecular imaging. Tumors were visible by all three imaging modalities. PET/CT had the highest imaging sensitivity at 3–3.5 h postadministration (mean %IA/g mean > 6) and visualized tumors earlier than the other two modalities with lower kidney uptake (mean %IA/g mean < 17) than previously reported FR-targeting agents in late stage disease. FMT showed relatively low FR-targeted agent in the bladder and kidneys, but yielded the lowest anatomical image resolution. MRI produced the highest resolution images, but it was difficult to distinguish tumors from abdominal organs during early progression since a FR-targeting MRI reporter was not used. Nevertheless, there was good correlation of imaging biomarkers between the three modalities. Tumors in the mouse ovarian cancer model could be detected using FR-targeted imaging as early as 2 weeks post i.p. injection of tumor cells. An imaging protocol should combine one or more of the modalities, e

  6. Prevention of hepatocellular carcinoma: potential targets, experimental models, and clinical challenges

    PubMed Central

    Hoshida, Yujin; Fuchs, Bryan C.; Tanabe, Kenneth K.

    2013-01-01

    Chronic fibrotic liver diseases such as viral hepatitis eventually develop liver cirrhosis, which causes occurrence of hepatocellular carcinoma (HCC). Given the limited therapeutic efficacy in advanced HCC, prevention of HCC development could be an effective strategy for improving patient prognosis. However, there is still no established therapy to meet the goal. Studies have elucidated a wide variety of molecular mechanisms and signaling pathways involved in HCC development. Genetically-engineered or chemically-treated experimental models of cirrhosis and HCC have been developed and shown their potential value in investigating molecular therapeutic targets and diagnostic biomarkers for HCC prevention. In this review, we overview potential targets of prevention and currently available experimental models, and discuss strategies to translate the findings into clinical practice. PMID:22873223

  7. Optimization of vascular-targeting drugs in a computational model of tumor growth

    NASA Astrophysics Data System (ADS)

    Gevertz, Jana

    2012-04-01

    A biophysical tool is introduced that seeks to provide a theoretical basis for helping drug design teams assess the most promising drug targets and design optimal treatment strategies. The tool is grounded in a previously validated computational model of the feedback that occurs between a growing tumor and the evolving vasculature. In this paper, the model is particularly used to explore the therapeutic effectiveness of two drugs that target the tumor vasculature: angiogenesis inhibitors (AIs) and vascular disrupting agents (VDAs). Using sensitivity analyses, the impact of VDA dosing parameters is explored, as is the effects of administering a VDA with an AI. Further, a stochastic optimization scheme is utilized to identify an optimal dosing schedule for treatment with an AI and a chemotherapeutic. The treatment regimen identified can successfully halt simulated tumor growth, even after the cessation of therapy.

  8. The 1994 Fermilab Fixed Target Program

    SciTech Connect

    Conrad, J. |

    1994-11-01

    This paper highlights the results of the Fermilab Fixed Target Program that were announced between October, 1993 and October, 1994. These results are drawn from 18 experiments that took data in the 1985, 1987 and 1990/91 fixed target running periods. For this discussion, the Fermilab Fixed Target Program is divided into 5 major topics: hadron structure, precision electroweak measurements, heavy quark production, polarization and magnetic moments, and searches for new phenomena. However, it should be noted that most experiments span several subtopics. Also, measurements within each subtopic often affect the results in other subtopics. For example, parton distributions from hadron structure measurements are used in the studies of heavy quark production.

  9. Comparative modeling: the state of the art and protein drug target structure prediction.

    PubMed

    Liu, Tianyun; Tang, Grace W; Capriotti, Emidio

    2011-07-01

    The goal of computational protein structure prediction is to provide three-dimensional (3D) structures with resolution comparable to experimental results. Comparative modeling, which predicts the 3D structure of a protein based on its sequence similarity to homologous structures, is the most accurate computational method for structure prediction. In the last two decades, significant progress has been made on comparative modeling methods. Using the large number of protein structures deposited in the Protein Data Bank (~65,000), automatic prediction pipelines are generating a tremendous number of models (~1.9 million) for sequences whose structures have not been experimentally determined. Accurate models are suitable for a wide range of applications, such as prediction of protein binding sites, prediction of the effect of protein mutations, and structure-guided virtual screening. In particular, comparative modeling has enabled structure-based drug design against protein targets with unknown structures. In this review, we describe the theoretical basis of comparative modeling, the available automatic methods and databases, and the algorithms to evaluate the accuracy of predicted structures. Finally, we discuss relevant applications in the prediction of important drug target proteins, focusing on the G protein-coupled receptor (GPCR) and protein kinase families.

  10. Reinforcement learning of targeted movement in a spiking neuronal model of motor cortex.

    PubMed

    Chadderdon, George L; Neymotin, Samuel A; Kerr, Cliff C; Lytton, William W

    2012-01-01

    Sensorimotor control has traditionally been considered from a control theory perspective, without relation to neurobiology. In contrast, here we utilized a spiking-neuron model of motor cortex and trained it to perform a simple movement task, which consisted of rotating a single-joint "forearm" to a target. Learning was based on a reinforcement mechanism analogous to that of the dopamine system. This provided a global reward or punishment signal in response to decreasing or increasing distance from hand to target, respectively. Output was partially driven by Poisson motor babbling, creating stochastic movements that could then be shaped by learning. The virtual forearm consisted of a single segment rotated around an elbow joint, controlled by flexor and extensor muscles. The model consisted of 144 excitatory and 64 inhibitory event-based neurons, each with AMPA, NMDA, and GABA synapses. Proprioceptive cell input to this model encoded the 2 muscle lengths. Plasticity was only enabled in feedforward connections between input and output excitatory units, using spike-timing-dependent eligibility traces for synaptic credit or blame assignment. Learning resulted from a global 3-valued signal: reward (+1), no learning (0), or punishment (-1), corresponding to phasic increases, lack of change, or phasic decreases of dopaminergic cell firing, respectively. Successful learning only occurred when both reward and punishment were enabled. In this case, 5 target angles were learned successfully within 180 s of simulation time, with a median error of 8 degrees. Motor babbling allowed exploratory learning, but decreased the stability of the learned behavior, since the hand continued moving after reaching the target. Our model demonstrated that a global reinforcement signal, coupled with eligibility traces for synaptic plasticity, can train a spiking sensorimotor network to perform goal-directed motor behavior.

  11. Optical model analyses of galactic cosmic ray fragmentation in hydrogen targets

    NASA Technical Reports Server (NTRS)

    Townsend, Lawrence W.

    1993-01-01

    Quantum-mechanical optical model methods for calculating cross sections for the fragmentation of galactic cosmic ray nuclei by hydrogen targets are presented. The fragmentation cross sections are calculated with an abrasion-ablation collision formalism. Elemental and isotopic cross sections are estimated and compared with measured values for neon, sulfur, and calcium ions at incident energies between 400A MeV and 910A MeV. Good agreement between theory and experiment is obtained.

  12. Reinforcement Learning of Targeted Movement in a Spiking Neuronal Model of Motor Cortex

    PubMed Central

    Chadderdon, George L.; Neymotin, Samuel A.; Kerr, Cliff C.; Lytton, William W.

    2012-01-01

    Sensorimotor control has traditionally been considered from a control theory perspective, without relation to neurobiology. In contrast, here we utilized a spiking-neuron model of motor cortex and trained it to perform a simple movement task, which consisted of rotating a single-joint “forearm” to a target. Learning was based on a reinforcement mechanism analogous to that of the dopamine system. This provided a global reward or punishment signal in response to decreasing or increasing distance from hand to target, respectively. Output was partially driven by Poisson motor babbling, creating stochastic movements that could then be shaped by learning. The virtual forearm consisted of a single segment rotated around an elbow joint, controlled by flexor and extensor muscles. The model consisted of 144 excitatory and 64 inhibitory event-based neurons, each with AMPA, NMDA, and GABA synapses. Proprioceptive cell input to this model encoded the 2 muscle lengths. Plasticity was only enabled in feedforward connections between input and output excitatory units, using spike-timing-dependent eligibility traces for synaptic credit or blame assignment. Learning resulted from a global 3-valued signal: reward (+1), no learning (0), or punishment (−1), corresponding to phasic increases, lack of change, or phasic decreases of dopaminergic cell firing, respectively. Successful learning only occurred when both reward and punishment were enabled. In this case, 5 target angles were learned successfully within 180 s of simulation time, with a median error of 8 degrees. Motor babbling allowed exploratory learning, but decreased the stability of the learned behavior, since the hand continued moving after reaching the target. Our model demonstrated that a global reinforcement signal, coupled with eligibility traces for synaptic plasticity, can train a spiking sensorimotor network to perform goal-directed motor behavior. PMID:23094042

  13. Dynamic Data Driven Applications Systems (DDDAS) modeling for automatic target recognition

    NASA Astrophysics Data System (ADS)

    Blasch, Erik; Seetharaman, Guna; Darema, Frederica

    2013-05-01

    The Dynamic Data Driven Applications System (DDDAS) concept uses applications modeling, mathematical algorithms, and measurement systems to work with dynamic systems. A dynamic systems such as Automatic Target Recognition (ATR) is subject to sensor, target, and the environment variations over space and time. We use the DDDAS concept to develop an ATR methodology for multiscale-multimodal analysis that seeks to integrated sensing, processing, and exploitation. In the analysis, we use computer vision techniques to explore the capabilities and analogies that DDDAS has with information fusion. The key attribute of coordination is the use of sensor management as a data driven techniques to improve performance. In addition, DDDAS supports the need for modeling from which uncertainty and variations are used within the dynamic models for advanced performance. As an example, we use a Wide-Area Motion Imagery (WAMI) application to draw parallels and contrasts between ATR and DDDAS systems that warrants an integrated perspective. This elementary work is aimed at triggering a sequence of deeper insightful research towards exploiting sparsely sampled piecewise dense WAMI measurements - an application where the challenges of big-data with regards to mathematical fusion relationships and high-performance computations remain significant and will persist. Dynamic data-driven adaptive computations are required to effectively handle the challenges with exponentially increasing data volume for advanced information fusion systems solutions such as simultaneous target tracking and ATR.

  14. Neuroprotection by a mitochondria-targeted drug in a Parkinson’s disease model

    PubMed Central

    Ghosh, Anamitra; Chandran, Karunakaran; Kalivendi, Shasi V.; Joseph, Joy; Antholine, William E.; Hillard, Cecilia J.; Kanthasamy, Arthi; Kanthasamy, Anumantha; Kalyanaraman, Balaraman

    2014-01-01

    The objective of this study was to assess the neuroprotective effects of a mitochondria-targeted antioxidant, Mito-Q10, the coenzyme-Q analog attached to a triphenylphosphonium cation that targets the antioxidant to mitochondria, in experimental models of Parkinson’s disease (PD). Primary mesencephalic neuronal cells and cultured dopaminergic cells were treated with 1-methyl-4-phenylpyridinium (MPP+), an active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and mice were used for testing the efficacy of Mito-Q10. MPP+ treatment caused a dose-dependent loss of tyrosine hydroxylase and membrane potential and an increase in caspase-3 activation in dopaminergic cells, which were reversed by Mito-Q10. MPTP treatment induced a loss of striatal dopamine and its metabolites, inactivation of mitochondrial aconitase in the substantia nigra, and a loss of locomotor activity in mice. Treatment with Mito-Q10 significantly inhibited both MPP+- and MPTP-induced neurotoxicity in cell culture and mouse models. Collectively, these results indicate that mitochondrial targeting of antioxidants is a promising neuroprotective strategy in this preclinical mouse model of PD. PMID:20828611

  15. One Class of Nonlinear Model Solutions for Flight Vehicles and Applications to Targeting and Guidance Schemes

    NASA Astrophysics Data System (ADS)

    Azimov, D.; Bishop, R.

    2012-09-01

    A complete analytical integration of the kinematic and dynamic equations of motion and applications of their integrals to targeting and guidance schemes for various dynamical models of various flight vehicles are presented. The general integral of these equations consists of six independent first integrals of motion and describes a class of non-steady flight trajectories in a maneuver plane. These first integrals represent explicit relationships for time, components of position and velocity vectors, and propulsive and aerodynamic accelerations. This explicitness with respect to the problem parameters can make these relationships useful in the design of airspace trajectories, and targeting and guidance schemes. It is also shown that the equations represent a 3rd-order vector differential equation used to develop the nonlinear maneuver model of a flight vehicle, and the state estimation and prediction schemes. Similarity in the dynamical models makes the first integrals valid for re-entry vehicles and missiles. An illustrative example has shown that the general integral provides a complete set of analytical solutions for nonlinear tracking, targeting, guidance and control problems with a wide range of terminal conditions, accelerations due to propulsive thrust and aerodynamic forces.

  16. Infrared transmission through cirrus clouds: a radiative model for target detection.

    PubMed

    Liou, K N; Takano, Y; Ou, S C; Heymsfield, A; Kreiss, W

    1990-05-01

    An IR transmission model for thin and subvisual cirrus clouds composed of hexagonal ice crystals with a specific use for target detection has been developed. The present model includes parameterizations of the ice crystal size distribution and the position of cirrus clouds in terms of ambient temperature. To facilitate the scattering and absorption calculations for hexagonal column and plate crystals in connection with transmission calculations, we have developed parameterized equations for their single scattering properties by using the results computed from a geometric ray-tracing program. The successive order-of-scattering approach has been used to account for multiple scattering of ice crystals associated with a target-detector system. The direct radiance, path radiance, and radiances produced by multiple scattering and background radiation involving cirrus clouds have been computed for 3.7- and 10-,microm wavelengths. We show that the background radiance at the 3.7-,microm wavelength is relatively small so that a high contrast may be obtained using this wavelength for the detection of airborne and ground-based objects in the presence of thin cirrus clouds. Finally, using the present model, including a simple prediction scheme for the ice crystal size distribution and cloud position, the transmission of infrared radiation through cirrus clouds can be efficiently evaluated if the target-detector geometry is defined.

  17. A linear-encoding model explains the variability of the target morphology in regeneration.

    PubMed

    Lobo, Daniel; Solano, Mauricio; Bubenik, George A; Levin, Michael

    2014-03-06

    A fundamental assumption of today's molecular genetics paradigm is that complex morphology emerges from the combined activity of low-level processes involving proteins and nucleic acids. An inherent characteristic of such nonlinear encodings is the difficulty of creating the genetic and epigenetic information that will produce a given self-assembling complex morphology. This 'inverse problem' is vital not only for understanding the evolution, development and regeneration of bodyplans, but also for synthetic biology efforts that seek to engineer biological shapes. Importantly, the regenerative mechanisms in deer antlers, planarian worms and fiddler crabs can solve an inverse problem: their target morphology can be altered specifically and stably by injuries in particular locations. Here, we discuss the class of models that use pre-specified morphological goal states and propose the existence of a linear encoding of the target morphology, making the inverse problem easy for these organisms to solve. Indeed, many model organisms such as Drosophila, hydra and Xenopus also develop according to nonlinear encodings producing linear encodings of their final morphologies. We propose the development of testable models of regeneration regulation that combine emergence with a top-down specification of shape by linear encodings of target morphology, driving transformative applications in biomedicine and synthetic bioengineering.

  18. A linear-encoding model explains the variability of the target morphology in regeneration

    PubMed Central

    Lobo, Daniel; Solano, Mauricio; Bubenik, George A.; Levin, Michael

    2014-01-01

    A fundamental assumption of today's molecular genetics paradigm is that complex morphology emerges from the combined activity of low-level processes involving proteins and nucleic acids. An inherent characteristic of such nonlinear encodings is the difficulty of creating the genetic and epigenetic information that will produce a given self-assembling complex morphology. This ‘inverse problem’ is vital not only for understanding the evolution, development and regeneration of bodyplans, but also for synthetic biology efforts that seek to engineer biological shapes. Importantly, the regenerative mechanisms in deer antlers, planarian worms and fiddler crabs can solve an inverse problem: their target morphology can be altered specifically and stably by injuries in particular locations. Here, we discuss the class of models that use pre-specified morphological goal states and propose the existence of a linear encoding of the target morphology, making the inverse problem easy for these organisms to solve. Indeed, many model organisms such as Drosophila, hydra and Xenopus also develop according to nonlinear encodings producing linear encodings of their final morphologies. We propose the development of testable models of regeneration regulation that combine emergence with a top-down specification of shape by linear encodings of target morphology, driving transformative applications in biomedicine and synthetic bioengineering. PMID:24402915

  19. Targeting and retention enhancement of quantum dots decorated with amino acids in an invertebrate model organism

    PubMed Central

    Xing, Rui; Chen, Xue-Dong; Zhou, Yan-Feng; Zhang, Jue; Su, Yuan-Yuan; Qiu, Jian-Feng; Sima, Yang-Hu; Zhang, Ke-Qin; He, Yao; Xu, Shi-Qing

    2016-01-01

    The use of quantum dots (QDs) in biological imaging applications and targeted drug delivery is expected to increase. However, the efficiency of QDs in drug targeting needs to be improved. Here, we show that amino acids linked to CdTe QDs significantly increased the targeted transfer efficiency and biological safety in the invertebrate model Bombyx mori. Compared with bare QDs530, the transfer efficiency of Ala- and Gly-conjugated QDs (QDs530-Ala and QDs530-Gly) in circulatory system increased by 2.6 ± 0.3 and 1.5 ± 0.3 times, and increased by 7.8 ± 0.9 and 2.9 ± 0.2 times in target tissue silk glands, respectively, after 24 h of QDs exposure. Meanwhile, the amount of conjugated QDs decreased by (68.4 ± 4.4)% and (46.7 ± 9.1)% in the non-target tissue fat body, and the speed at which they entered non-target circulating blood cells significantly decreased. The resultant QDs530-Ala revealed a better structural integrity in tissues and a longer retention time in hemolymph than that of QDs530 after exposure via the dorsal vessel. On the other hand, QDs530-Ala significantly reduced the toxicity to hemocytes, silk gland, and fat body, and reduced the amount of reactive oxygen species (ROS) in tissues. PMID:26806642

  20. Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model.

    PubMed

    Lee, Mikyung; Huang, Ruili; Tong, Weida

    2016-03-01

    Nuclear receptors (NRs) are ligand-activated transcriptional regulators that play vital roles in key biological processes such as growth, differentiation, metabolism, reproduction, and morphogenesis. Disruption of NRs can result in adverse health effects such as NR-mediated endocrine disruption. A comprehensive understanding of core transcriptional targets regulated by NRs helps to elucidate their key biological processes in both toxicological and therapeutic aspects. In this study, we applied a probabilistic graphical model to identify the transcriptional targets of NRs and the biological processes they govern. The Tox21 program profiled a collection of approximate 10 000 environmental chemicals and drugs against a panel of human NRs in a quantitative high-throughput screening format for their NR disruption potential. The Japanese Toxicogenomics Project, one of the most comprehensive efforts in the field of toxicogenomics, generated large-scale gene expression profiles on the effect of 131 compounds (in its first phase of study) at various doses, and different durations, and their combinations. We applied author-topic model to these 2 toxicological datasets, which consists of 11 NRs run in either agonist and/or antagonist mode (18 assays total) and 203 in vitro human gene expression profiles connected by 52 shared drugs. As a result, a set of clusters (topics), which consists of a set of NRs and their associated target genes were determined. Various transcriptional targets of the NRs were identified by assays run in either agonist or antagonist mode. Our results were validated by functional analysis and compared with TRANSFAC data. In summary, our approach resulted in effective identification of associated/affected NRs and their target genes, providing biologically meaningful hypothesis embedded in their relationships.

  1. Construction of a mouse model of factor VIII deficiency by gene targeting

    SciTech Connect

    Bi, L.; Lawler, A.; Gearhart, J.

    1994-09-01

    To develop a small animal model of hemophilia A for gene therapy experiments, we set out to construct a mouse model for factor VIII deficiency by gene targeting. First, we screened a mouse liver cDNA library using a human FVIII cDNA probe. We cloned a 2.6 Kb partial mouse factor VIII cDNA which extends from 800 base pairs of the 3{prime} end of exon 14 to the 5{prime} end of exon 26. A mouse genomic library made from strain 129 was then screened to obtain genomic fragments covering the exons desired for homologous recombination. Two genomic clones were obtained, and one covering exon 15 through 22 was used for gene targeting. To make gene targeting constructs, a 5.8 Kb genomic DNA fragment covering exons 15 to 19 of the mouse FVIII gene was subcloned, and the neo expression cassette was inserted into exons 16 and 17 separately by different strategies. These two constructs were named MFVIIIC-16 and MFVIIIC-17. The constructs were linearized and transfected into strain 129 mouse ES cells by electroporation. Factor VIII gene-knockout ES cell lines were selected by G-418 and screened by genomic Southern blots. Eight exon 16 targeted cell lines and five exon 17 targeted cell lines were obtained. Three cell lines from each construct were injected into blastocysts and surgically transferred into foster mothers. Multiple chimeric mice with 70-90% hair color derived from the ES-cell genotype were seen with both constructs. Germ line transmission of the ES-cell genotype has been obtained for the MFVIIIC-16 construct, and multiple hemophilia A carrier females have been identified. Factor VIII-deficient males will be conceived soon.

  2. Parameters inversing of polarized bidirectional reflectance distribution function model for target rough surface

    NASA Astrophysics Data System (ADS)

    Liu, Qing; Zhan, Yong-hong; Yang, Di; Zeng, Chang-e.

    2014-11-01

    In this paper, we try to find a model that can apply to predict the polarization characteristics of the targets on the ground correctly. In the first place, we give an introduction to several kinds of existing models which are divided into three categories: Empirical models are precise but occupy too much source of computer; Physical-based models can predict the phenomenon of reflection exactly but hardly get the final results; Semi-empirical models have both advantages mentioned above and avoid their disadvantages effectively. Then we make an analysis of the Priest-Germer (PG) pBRDF model, one of semi-empirical models, which is suitable for our study. The methods of parameters inversing and testing are proposed based on this model and the test system from which we can get enough data to verify the accuracy of the model is designed independently. At last, we make a simulation of the whole process of the parameters inversing based on PG pBRDF model. From the analysis of the simulation curves, we briefly know the direction we go in the following work to make an amendment.

  3. Adaptable active contour model with applications to infrared ship target segmentation

    NASA Astrophysics Data System (ADS)

    Fang, Lingling; Wang, Xianghai; Wan, Yu

    2016-07-01

    Active contour model is widely and popularly used in the field of image segmentation because of its superior theoretical properties and efficient numerical methods. An algorithm to segment a ship target in infrared (IR) images using Chan-Vese (C-V) active contour model is proposed here. The method effectively integrates both image regional and boundary information by an adaptable weight function. The method can segment IR ship images, which usually contain noises, blurry boundaries, and heterogeneous regions. In addition, compared with the state-of-the-art methods, experiment results demonstrate the performance and effectiveness of this method.

  4. The last glacial termination: targets for climate modelling and proxy-based reconstructions

    NASA Astrophysics Data System (ADS)

    Renssen, Hans; Blockley, Simon P.; Rasmussen, Sune O.; Roche, Didier M.; Valdes, Paul J.; Nisancioglu, Kerim M.; Working Group 3 Members Of Intimate

    2013-04-01

    During the last glacial termination, the climate system experienced a major reorganisation, making this time interval a crucial period for our understanding of climate change. Despite a basic understanding of these changes and a reasonable level of agreement between data and model simulations, a deeper understanding of the last glacial termination remains a long standing goal: we are still faced with the dual challenge of reconstructing the climate history from incomplete and uncertain proxy data, and accurately simulating the climate history with physics-based climate models. There are, however, significant advantages in attempting to reliably integrate palaeoclimate data with model simulations, not least because it is necessary to examine the limitations of both current models and palaeoclimate records before testing possible forcing mechanisms. For the model studies, palaeodata play a crucial role, both as a source of (1) climate forcings for the modelling experiments and (2) palaeoclimate information that is required for model evaluation. Therefore, interaction between the modelling and data communities is essential. For this purpose, and with the last termination as a target, a working group has been set up within the INTIMATE (INTegration of Ice core, MArine and TErrestrial records of the last termination) COST Action (http://cost-es0907.geoenvi.org). We report on the outcome of a workshop of this working group, discussing the state of knowledge of the forcings and various aspects of climate variability during the last termination. We focus in particular on the main uncertainties in the climate signals and the forcings. We discuss the major problems that must be solved to make further progress in our understanding. This requires a joint effort of paleodata, chronology, and climate modelling communities. A number of specific targets for these communities are identified.

  5. Four-jet production in single- and double-parton scattering within high-energy factorization

    NASA Astrophysics Data System (ADS)

    Kutak, Krzysztof; Maciula, Rafal; Serino, Mirko; Szczurek, Antoni; van Hameren, Andreas

    2016-04-01

    We perform a first study of 4-jet production in a complete high-energy factorization (HEF) framework. We include and discuss contributions from both single-parton scattering (SPS) and double-parton scattering (DPS). The calculations are performed for kinematical situations relevant for two experimental measurements (ATLAS and CMS) at the LHC. We compare our results to those reported by the ATLAS and CMS collaborations for different sets of kinematical cuts. The results of the HEF approach are compared with their counterparts for collinear factorization. For symmetric cuts the DPS HEF result is considerably smaller than the one obtained with collinear factorization. The mechanism leading to this difference is of kinematical nature. We conclude that an analysis of inclusive 4-jet production with asymmetric p T -cuts below 50 GeV would be useful to enhance the DPS contribution relative to the SPS contribution. In contrast to the collinear approach, the HEF approach nicely describes the distribution of the Δ S variable, which involves all four jets and their angular correlations.

  6. New parton distribution functions from a global analysis of quantum chromodynamics

    NASA Astrophysics Data System (ADS)

    Dulat, Sayipjamal; Hou, Tie-Jiun; Gao, Jun; Guzzi, Marco; Huston, Joey; Nadolsky, Pavel; Pumplin, Jon; Schmidt, Carl; Stump, Daniel; Yuan, C.-P.

    2016-02-01

    We present new parton distribution functions (PDFs) at next-to-next-to-leading order (NNLO) from the CTEQ-TEA global analysis of quantum chromodynamics. These differ from previous CT PDFs in several respects, including the use of data from LHC experiments and the new D0 charged-lepton rapidity asymmetry data, as well as the use of a more flexible parametrization of PDFs that, in particular, allows a better fit to different combinations of quark flavors. Predictions for important LHC processes, especially Higgs boson production at 13 TeV, are presented. These CT14 PDFs include a central set and error sets in the Hessian representation. For completeness, we also present the CT14 PDFs determined at the LO and the NLO in QCD. Besides these general-purpose PDF sets, we provide a series of (N)NLO sets with various αs values and additional sets in general-mass variable flavor number schemes, to deal with heavy partons, with up to three, four, and six active flavors.

  7. Hard scattering of partons as a probe of collisions at RHIC using the STAR detector system

    SciTech Connect

    Christie, W.B.

    1995-07-15

    Presented here is the current state of the author`s investigations into the use of hard probes to study pp, pA, and AA collisions at the Relativistic Heavy Ion Collider (RHIC) being built at Brookhaven National Laboratory. The overall goal of the RHIC program is the discovery and study of the Quark-Gluon Plasma (QGP), which is predicted to be formed at the high energy densities reached at RHIC in high energy AA collisions. The term {open_quotes}Hard probes{close_quotes} as used in this document includes those particles whose origin is the result of a direct hard parton scatter (i.e qq, qg, or gg). The final states of these hard parton scatters which the author proposes to study include dijets, gamma-jet coincidences, and inclusive high P{sub t} particle spectra. A brief discussion of the physics objectives is given in section 1. This is followed by an introduction to the STAR detector system in section 2, with particular details given for the proposed STAR Electromagnetic Calorimeter (EMC). The present simulation studies and results are given in section 3. The author concludes with a summary and a discussion of future plans in section 4.

  8. Large-pT production of D mesons at the LHCb in the parton Reggeization approach

    NASA Astrophysics Data System (ADS)

    Karpishkov, A. V.; Saleev, V. A.; Shipilova, A. V.

    2016-12-01

    The production of D mesons in proton-proton collisions at the LHCb detector is studied. We consider the single production of D0/D¯0, D±, D*±, and Ds± mesons and correlation spectra in the production of D D ¯ and D D pairs at the √{S }=7 TeV and √{S }=13 TeV . In case of the single D -meson production we calculate differential cross sections over transverse momentum pT while in the pair D D ¯ , D D -meson production the cross sections are calculated over the azimuthal angle difference Δ φ , rapidity difference Δ y , invariant mass of the pair M and over the pT of the one meson from a pair. The cross sections are obtained at the leading order of the parton Reggeization approach using Kimber-Martin-Ryskin unintegrated parton distribution functions in a proton. To describe the D -meson production we use universal scale-dependent c -quark and gluon fragmentation functions fitted to e+e- annihilation data from CERN LEP1. Our predictions find a good agreement with the LHCb Collaboration data within uncertainties and without free parameters.

  9. New parton distribution functions from a global analysis of quantum chromodynamics

    DOE PAGES

    Dulat, Sayipjamal; Hou, Tie -Jiun; Gao, Jun; ...

    2016-02-16

    Here, we present new parton distribution functions (PDFs) up to next-to-next-to-leading order (NNLO) from the CTEQ-TEA global analysis of quantum chromodynamics. These differ from previous CT PDFs in several respects, including the use of data from LHC experiments and the new D0 charged lepton rapidity asymmetry data, as well as the use of more flexible parametrization of PDFs that, in particular, allows a better fit to different combinations of quark flavors. Predictions for important LHC processes, especially Higgs boson production at 13 TeV, are presented. These CT14 PDFs include a central set and error sets in the Hessian representation. Formore » completeness, we also present the CT14 PDFs determined at the leading order (LO) and the next-to-leading order (NLO) in QCD. Besides these general-purpose PDF sets, we provide a series of (N)NLO sets with various αs values and additional sets in general-mass variable flavor number (GM-VFN) schemes, to deal with heavy partons, with up to 3, 4, and 6 active flavors.« less

  10. New parton distribution functions from a global analysis of quantum chromodynamics

    SciTech Connect

    Dulat, Sayipjamal; Hou, Tie -Jiun; Gao, Jun; Guzzi, Marco; Nadolsky, Pavel; Pumplin, Jon; Schmidt, Carl; Stump, Daniel; Yuan, C. -P.; Huston, Joey

    2016-02-16

    Here, we present new parton distribution functions (PDFs) up to next-to-next-to-leading order (NNLO) from the CTEQ-TEA global analysis of quantum chromodynamics. These differ from previous CT PDFs in several respects, including the use of data from LHC experiments and the new D0 charged lepton rapidity asymmetry data, as well as the use of more flexible parametrization of PDFs that, in particular, allows a better fit to different combinations of quark flavors. Predictions for important LHC processes, especially Higgs boson production at 13 TeV, are presented. These CT14 PDFs include a central set and error sets in the Hessian representation. For completeness, we also present the CT14 PDFs determined at the leading order (LO) and the next-to-leading order (NLO) in QCD. Besides these general-purpose PDF sets, we provide a series of (N)NLO sets with various αs values and additional sets in general-mass variable flavor number (GM-VFN) schemes, to deal with heavy partons, with up to 3, 4, and 6 active flavors.

  11. Polarised Parton Densities from the Fits to the Deep Inelastic Spin Asymmetries on Nucleons

    NASA Astrophysics Data System (ADS)

    Bartelski, Jan; Tatur, Stanislaw

    2001-07-01

    We have updated our next to leading order QCD fit for polarised parton densities [S. Tatur, J. Bartelski, M. Kurzela, Acta Phys. Pol. B31, 647 (2000)] using recent experimental data on the deep inelastic spin asymmetries on nucleons. Our distributions have functional form inspired by the unpolarised ones given by MRST (Martin, Roberts, Stirling and Thorne) fit. In addition to usually used data sample (averaged over variable Q2 for the same value of x variable) we have also considered the points with the same x and different Q2. Our fits to both groups of data give very similar results with substantial antiquark contribution in the measured region of x. In the first case we get rather small (Δ G=0.31) gluon polarisation. For the non averaged data the best fit is obtained when gluon contribution vanishes at Q2=1GeV2. Our new parametrisation of parton densities and additional experimental data taken into account do not change much our previous results.

  12. NLO+NLL squark and gluino production cross sections with threshold-improved parton distributions.

    PubMed

    Beenakker, Wim; Borschensky, Christoph; Krämer, Michael; Kulesza, Anna; Laenen, Eric; Marzani, Simone; Rojo, Juan

    We present updated predictions for the cross sections for pair production of squarks and gluinos at the LHC Run II. First of all, we update the calculations based on NLO+NLL partonic cross sections by using the NNPDF3.0NLO global analysis. This study includes a full characterization of theoretical uncertainties from higher orders, PDFs and the strong coupling. Then we explore the implications for this calculation of the recent NNPDF3.0 PDFs with NLO+NLL threshold resummation. We find that the shift in the results induced by the threshold-improved PDFs is within the total theory uncertainty band of the calculation based on NLO PDFs. However, we also observe that the central values of the NLO+NLL cross sections are modified both in a qualitative and a quantitative way, illustrating the relevance and impact of using threshold-improved PDFs together with resummed partonic cross sections. The updated NLO+NLL cross sections based on NNPDF3.0NLO are publicly available in the NLL-fast format, and should be an important ingredient for the interpretation of the searches for supersymmetric particles at Run II.

  13. The asymptotic behaviour of parton distributions at small and large x.

    PubMed

    Ball, Richard D; Nocera, Emanuele R; Rojo, Juan

    2016-01-01

    It has been argued from the earliest days of quantum chromodynamics that at asymptotically small values of x the parton distribution functions (PDFs) of the proton behave as [Formula: see text], where the values of [Formula: see text] can be deduced from Regge theory, while at asymptotically large values of x the PDFs behave as [Formula: see text], where the values of [Formula: see text] can be deduced from the Brodsky-Farrar quark counting rules. We critically examine these claims by extracting the exponents [Formula: see text] and [Formula: see text] from various global fits of parton distributions, analysing their scale dependence, and comparing their values to the naive expectations. We find that for valence distributions both Regge theory and counting rules are confirmed, at least within uncertainties, while for sea quarks and gluons the results are less conclusive. We also compare results from various PDF fits for the structure function ratio [Formula: see text] at large x, and caution against unrealistic uncertainty estimates due to overconstrained parametrisations.

  14. THE ANALYSIS OF GREENHOUSE GAS REDUCTION TARGETS IN JAPAN USING A COMPUTABLE GENERAL EQUILIBRIUM MODEL

    NASA Astrophysics Data System (ADS)

    Namazu, Michiko; Fujimori, Shinichiro; Matsuoka, Yuzuru

    In this study, a recursive dynamic Computable General Equilibrium (CGE) model which can deal with Greenhouse Gas (GHG) constraint is applied to Japan. Based on several references, Japan's emissions reduction targets are determined as 25% reduction from 1990 level by 2020 and 80% reduction from 2005 level by 2050 in this study. Several cases with different scenarios for nuclear power plant, international emissions trading, and CO2 Capture and Strage (CCS) technology are simulated using the CGE model. By comparison among the results of each case, the effects, especially economic effects are evaluated and analyzed quantitatively. The results show that the most important counter measure to achieve GHG emissions reduction targets in Japan is whether Japan joins international emissions trading or not. In a no-trading case, in which GHG emissions constraints are imposed and Japan does not participate to the trading, GHG reduction costs reach 2,560 USD/tCO2-eq,yr (2005 price) in 2050. In addition, Gross Domestic Product (GDP) decreases 3.8% compared with a counter measure case in which GHG constraints are imposed but the emissions trading is allowed. The results also show that in case Japan targets no nuclear power plants in 2050, CCS technology and emissions trading are able to make up for the gap resulted from the nuclear power decrease. About the speed of CCS technology introduction, the share of power plants with CCS technology is changed depended on the speed; however, GDP and GHG reduction costs do not affected so much.

  15. Identification of Treatment Targets in a Genetic Mouse Model of Voluntary Methamphetamine Drinking.

    PubMed

    Phillips, T J; Mootz, J R K; Reed, C

    2016-01-01

    Methamphetamine has powerful stimulant and euphoric effects that are experienced as rewarding and encourage use. Methamphetamine addiction is associated with debilitating illnesses, destroyed relationships, child neglect, violence, and crime; but after many years of research, broadly effective medications have not been identified. Individual differences that may impact not only risk for developing a methamphetamine use disorder but also affect treatment response have not been fully considered. Human studies have identified candidate genes that may be relevant, but lack of control over drug history, the common use or coabuse of multiple addictive drugs, and restrictions on the types of data that can be collected in humans are barriers to progress. To overcome some of these issues, a genetic animal model comprised of lines of mice selectively bred for high and low voluntary methamphetamine intake was developed to identify risk and protective alleles for methamphetamine consumption, and identify therapeutic targets. The mu opioid receptor gene was supported as a target for genes within a top-ranked transcription factor network associated with level of methamphetamine intake. In addition, mice that consume high levels of methamphetamine were found to possess a nonfunctional form of the trace amine-associated receptor 1 (TAAR1). The Taar1 gene is within a mouse chromosome 10 quantitative trait locus for methamphetamine consumption, and TAAR1 function determines sensitivity to aversive effects of methamphetamine that may curb intake. The genes, gene interaction partners, and protein products identified in this genetic mouse model represent treatment target candidates for methamphetamine addiction.

  16. Reduced-order model for underwater target identification using proper orthogonal decomposition

    NASA Astrophysics Data System (ADS)

    Ramesh, Sai Sudha; Lim, Kian Meng

    2017-03-01

    Research on underwater acoustics has seen major development over the past decade due to its widespread applications in domains such as underwater communication/navigation (SONAR), seismic exploration and oceanography. In particular, acoustic signatures from partially or fully buried targets can be used in the identification of buried mines for mine counter measures (MCM). Although there exist several techniques to identify target properties based on SONAR images and acoustic signatures, these methods first employ a feature extraction method to represent the dominant characteristics of a data set, followed by the use of an appropriate classifier based on neural networks or the relevance vector machine. The aim of the present study is to demonstrate the applications of proper orthogonal decomposition (POD) technique in capturing dominant features of a set of scattered pressure signals, and subsequent use of the POD modes and coefficients in the identification of partially buried underwater target parameters such as its location, size and material density. Several numerical examples are presented to demonstrate the performance of the system identification method based on POD. Although the present study is based on 2D acoustic model, the method can be easily extended to 3D models and thereby enables cost-effective representations of large-scale data.

  17. Tuberculosis control in China: use of modelling to develop targets and policies.

    PubMed

    Lin, Hsien-Ho; Wang, Lixia; Zhang, Hui; Ruan, Yunzhou; Chin, Daniel P; Dye, Christopher

    2015-11-01

    It is unclear if current programmes in China can achieve the post-2015 global targets for tuberculosis - 50% reduction in incidence and a 75% reduction in mortality by 2025. Chinese policy-makers need to maintain the recent decline in the prevalence of tuberculosis, while revising control policies to cope with an epidemic of drug-resistant tuberculosis and the effects of ongoing health reform. Health reforms are expected to shift patients from tuberculosis dispensaries to designated hospitals. We developed a mathematical model of tuberculosis control in China to help set appropriate targets and prioritize interventions that might be implemented in the next 10 years. This model indicates that, even under the most optimistic scenario - improved treatment in tuberculosis dispensaries, introduction of a new effective regimen for the treatment of drug-susceptible tuberculosis and optimal care of cases of multidrug-resistant tuberculosis - the current global targets for tuberculosis are unlikely to be reached. However, reductions in the incidence of multidrug-resistant tuberculosis should be feasible. We conclude that a shift of patients from tuberculosis dispensaries to designated hospitals is likely to hamper efforts at tuberculosis control if cure rates in the designated hospitals cannot be maintained at a high level. Our results can inform the planning of tuberculosis control in China.

  18. Tuberculosis control in China: use of modelling to develop targets and policies

    PubMed Central

    Wang, Lixia; Zhang, Hui; Ruan, Yunzhou; Chin, Daniel P; Dye, Christopher

    2015-01-01

    Abstract It is unclear if current programmes in China can achieve the post-2015 global targets for tuberculosis – 50% reduction in incidence and a 75% reduction in mortality by 2025. Chinese policy-makers need to maintain the recent decline in the prevalence of tuberculosis, while revising control policies to cope with an epidemic of drug-resistant tuberculosis and the effects of ongoing health reform. Health reforms are expected to shift patients from tuberculosis dispensaries to designated hospitals. We developed a mathematical model of tuberculosis control in China to help set appropriate targets and prioritize interventions that might be implemented in the next 10 years. This model indicates that, even under the most optimistic scenario – improved treatment in tuberculosis dispensaries, introduction of a new effective regimen for the treatment of drug-susceptible tuberculosis and optimal care of cases of multidrug-resistant tuberculosis – the current global targets for tuberculosis are unlikely to be reached. However, reductions in the incidence of multidrug-resistant tuberculosis should be feasible. We conclude that a shift of patients from tuberculosis dispensaries to designated hospitals is likely to hamper efforts at tuberculosis control if cure rates in the designated hospitals cannot be maintained at a high level. Our results can inform the planning of tuberculosis control in China. PMID:26549907

  19. Modeling human echolocation of near-range targets with an audible sonar.

    PubMed

    Kuc, Roman; Kuc, Victor

    2016-02-01

    Blind humans echolocate nearby targets by emitting palatal clicks and perceiving echoes that the auditory system is not able to resolve temporally. The mechanism for perceiving near-range echoes is not known. This paper models the direct mouth-to-ear signal (MES) and the echo to show that the echo enhances the high-frequency components in the composite MES/echo signal with features that allow echolocation. The mouth emission beam narrows with increasing frequency and exhibits frequency-dependent transmission notches in the backward direction toward the ears as predicted by the piston-in-sphere model. The ears positioned behind the mouth detect a MES that contains predominantly the low frequencies contained in the emission. Hence the high-frequency components in the emission that are perceived by the ears are enhanced by the echoes. A pulse/echo audible sonar verifies this model by echolocating targets from 5 cm range, where the MES and echo overlap significantly, to 55 cm. The model predicts that unambiguous ranging occurs over a limited range and that there is an optimal range that produces the highest range resolution.

  20. Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism.

    PubMed

    Gut, Nadine K; Winn, Philip

    2015-03-25

    The pedunculopontine tegmental nucleus (PPTg) has been proposed as a target for deep brain stimulation (DBS) in parkinsonian patients, particularly for symptoms such as gait and postural difficulties refractory to dopaminergic treatments. Several patients have had electrodes implanted aimed at the PPTg, but outcomes have been disappointing, with little evidence that gait and posture are improved. The PPTg is a heterogeneous structure. Consequently, exact target sites in PPTg, possible DBS mechanisms, and potential benefits still need systematic investigation in good animal models. We have investigated the role of PPTg in gait, developed a refined model of parkinsonism including partial loss of the PPTg with bilateral destruction of nigrostriatal dopamine neurons that mimics human pathophysiology, and investigated the effect of DBS at different PPTg locations on gait and posture using a wireless device that lets rats move freely while receiving stimulation. Neither partial nor complete lesions of PPTg caused gait deficits, underlining questions raised previously about the status of PPTg as a motor control structure. The effect of DBS in the refined and standard model of parkinsonism were very different despite minimal behavioral differences in nonstimulation control conditions. Anterior PPTg DBS caused severe episodes of freezing and worsened gait, whereas specific gait parameters were mildly improved by stimulation of posterior PPTg. These results emphasize the critical importance of intra-PPTg DBS location and highlight the need to take PPTg degeneration into consideration when modeling parkinsonian symptoms. They also further implicate a role for PPTg in the pathophysiology of parkinsonism.

  1. PROPERTIES OF 42 SOLAR-TYPE KEPLER TARGETS FROM THE ASTEROSEISMIC MODELING PORTAL

    SciTech Connect

    Metcalfe, T. S.; Mathur, S.; Creevey, O. L.; Doğan, G.; Christensen-Dalsgaard, J.; Karoff, C.; Trampedach, R.; Xu, H.; Bedding, T. R.; Benomar, O.; Chaplin, W. J.; Campante, T. L.; Davies, G. R.; Brown, B. P.; Buzasi, D. L.; Çelik, Z.; Cunha, M. S.; Deheuvels, S.; Derekas, A.; Mauro, M. P. Di; and others

    2014-10-01

    Recently the number of main-sequence and subgiant stars exhibiting solar-like oscillations that are resolved into individual mode frequencies has increased dramatically. While only a few such data sets were available for detailed modeling just a decade ago, the Kepler mission has produced suitable observations for hundreds of new targets. This rapid expansion in observational capacity has been accompanied by a shift in analysis and modeling strategies to yield uniform sets of derived stellar properties more quickly and easily. We use previously published asteroseismic and spectroscopic data sets to provide a uniform analysis of 42 solar-type Kepler targets from the Asteroseismic Modeling Portal. We find that fitting the individual frequencies typically doubles the precision of the asteroseismic radius, mass, and age compared to grid-based modeling of the global oscillation properties, and improves the precision of the radius and mass by about a factor of three over empirical scaling relations. We demonstrate the utility of the derived properties with several applications.

  2. Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion

    PubMed Central

    Sengers, Bram G.; McGinty, Sean; Nouri, Fatma Z.; Argungu, Maryam; Hawkins, Emma; Hadji, Aymen; Weber, Andrew; Taylor, Adam; Sepp, Armin

    2016-01-01

    ABSTRACT We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface. The bispecific antibody in solution binds either of the two targets first, and then cross-links with the second one while on the cell surface, subject to rate-limiting lateral diffusion step within the lifetime of the monovalently engaged antibody-antigen complex. At experimental densities, only a small fraction of the free targets is expected to lie within the reach of the antibody binding sites at any time. Using ordinary differential equation and Monte Carlo simulation-based models, we validated this approach against an independently published anti-CD4/CD70 DuetMab experimental data set. As a result of dimensional reduction, the cell surface reaction is expected to be so rapid that, in agreement with the experimental data, no monovalently bound bispecific antibody binary complexes accumulate until cross-linking is complete. The dissociation of the bispecific antibody from the ternary cross-linked complex is expected to be significantly slower than that from either of the monovalently bound variants. We estimate that the effective affinity of the bivalently bound bispecific antibody is enhanced for about 4 orders of magnitude over that of the monovalently bound species. This avidity enhancement allows for the highly specific binding of anti-CD4/CD70 DuetMab to the cells that are positive for both target antigens over those that express only one or the other We suggest that the lateral diffusion of target antigens in the cell membrane also plays a key role in the avidity effect of natural antibodies and other bivalent ligands in their interactions with their respective cell surface receptors. PMID:27097222

  3. Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion.

    PubMed

    Sengers, Bram G; McGinty, Sean; Nouri, Fatma Z; Argungu, Maryam; Hawkins, Emma; Hadji, Aymen; Weber, Andrew; Taylor, Adam; Sepp, Armin

    2016-07-01

    We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface. The bispecific antibody in solution binds either of the two targets first, and then cross-links with the second one while on the cell surface, subject to rate-limiting lateral diffusion step within the lifetime of the monovalently engaged antibody-antigen complex. At experimental densities, only a small fraction of the free targets is expected to lie within the reach of the antibody binding sites at any time. Using ordinary differential equation and Monte Carlo simulation-based models, we validated this approach against an independently published anti-CD4/CD70 DuetMab experimental data set. As a result of dimensional reduction, the cell surface reaction is expected to be so rapid that, in agreement with the experimental data, no monovalently bound bispecific antibody binary complexes accumulate until cross-linking is complete. The dissociation of the bispecific antibody from the ternary cross-linked complex is expected to be significantly slower than that from either of the monovalently bound variants. We estimate that the effective affinity of the bivalently bound bispecific antibody is enhanced for about 4 orders of magnitude over that of the monovalently bound species. This avidity enhancement allows for the highly specific binding of anti-CD4/CD70 DuetMab to the cells that are positive for both target antigens over those that express only one or the other We suggest that the lateral diffusion of target antigens in the cell membrane also plays a key role in the avidity effect of natural antibodies and other bivalent ligands in their interactions with their respective cell surface receptors.

  4. Proteome scale comparative modeling for conserved drug and vaccine targets identification in Corynebacterium pseudotuberculosis.

    PubMed

    Hassan, Syed Shah; Tiwari, Sandeep; Guimarães, Luís Carlos; Jamal, Syed Babar; Folador, Edson; Sharma, Neha Barve; de Castro Soares, Siomar; Almeida, Síntia; Ali, Amjad; Islam, Arshad; Póvoa, Fabiana Dias; de Abreu, Vinicius Augusto Carvalho; Jain, Neha; Bhattacharya, Antaripa; Juneja, Lucky; Miyoshi, Anderson; Silva, Artur; Barh, Debmalya; Turjanski, Adrian Gustavo; Azevedo, Vasco; Ferreira, Rafaela Salgado

    2014-01-01

    Corynebacterium pseudotuberculosis (Cp) is a pathogenic bacterium that causes caseous lymphadenitis (CLA), ulcerative lymphangitis, mastitis, and edematous to a broad spectrum of hosts, including ruminants, thereby threatening economic and dairy industries worldwide. Currently there is no effective drug or vaccine available against Cp. To identify new targets, we adopted a novel integrative strategy, which began with the prediction of the modelome (tridimensional protein structures for the proteome of an organism, generated through comparative modeling) for 15 previously sequenced C. pseudotuberculosis strains. This pan-modelomics approach identified a set of 331 conserved proteins having 95-100% intra-species sequence similarity. Next, we combined subtractive proteomics and modelomics to reveal a set of 10 Cp proteins, which may be essential for the bacteria. Of these, 4 proteins (tcsR, mtrA, nrdI, and ispH) were essential and non-host homologs (considering man, horse, cow and sheep as hosts) and satisfied all criteria of being putative targets. Additionally, we subjected these 4 proteins to virtual screening of a drug-like compound library. In all cases, molecules predicted to form favorable interactions and which showed high complementarity to the target were found among the top ranking compounds. The remaining 6 essential proteins (adk, gapA, glyA, fumC, gnd, and aspA) have homologs in the host proteomes. Their active site cavities were compared to the respective cavities in host proteins. We propose that some of these proteins can be selectively targeted using structure-based drug design approaches (SBDD). Our results facilitate the selection of C. pseudotuberculosis putative proteins for developing broad-spectrum novel drugs and vaccines. A few of the targets identified here have been validated in other microorganisms, suggesting that our modelome strategy is effective and can also be applicable to other pathogens.

  5. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

    PubMed Central

    Velena, Astrida; Zarkovic, Neven; Gall Troselj, Koraljka; Bisenieks, Egils; Krauze, Aivars; Poikans, Janis; Duburs, Gunars

    2016-01-01

    Many 1,4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA). Several commercially available calcium antagonist, 1,4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA. Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1,4-DHPs are presented. Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted. Comparison of the AOA of different DHPs and other antioxidants is also given. According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry. PMID:26881016

  6. Hydrodynamic modeling of targeted magnetic-particle delivery in a blood vessel.

    PubMed

    Weng, Huei Chu

    2013-03-01

    Since the flow of a magnetic fluid could easily be influenced by an external magnetic field, its hydrodynamic modeling promises to be useful for magnetically controllable delivery systems. It is desirable to understand the flow fields and characteristics before targeted magnetic particles arrive at their destination. In this study, we perform an analysis for the effects of particles and a magnetic field on biomedical magnetic fluid flow to study the targeted magnetic-particle delivery in a blood vessel. The fully developed solutions of velocity, flow rate, and flow drag are derived analytically and presented for blood with magnetite nanoparticles at body temperature. Results reveal that in the presence of magnetic nanoparticles, a minimum magnetic field gradient (yield gradient) is required to initiate the delivery. A magnetic driving force leads to the increase in velocity and has enhancing effects on flow rate and flow drag. Such a magnetic driving effect can be magnified by increasing the particle volume fraction.

  7. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.

    PubMed

    Velena, Astrida; Zarkovic, Neven; Gall Troselj, Koraljka; Bisenieks, Egils; Krauze, Aivars; Poikans, Janis; Duburs, Gunars

    2016-01-01

    Many 1,4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA). Several commercially available calcium antagonist, 1,4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA. Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1,4-DHPs are presented. Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted. Comparison of the AOA of different DHPs and other antioxidants is also given. According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry.

  8. Computational modeling of joint U.S.-Russian experiments relevant to magnetic compression/magnetized target fusion (MAGO/MTF)

    SciTech Connect

    Sheehey, P.T.; Faehl, R.J.; Kirkpatrick, R.C.; Lindemuth, I.R.

    1997-12-31

    Magnetized Target Fusion (MTF) experiments, in which a preheated and magnetized target plasma is hydrodynamically compressed to fusion conditions, present some challenging computational modeling problems. Recently, joint experiments relevant to MTF (Russian acronym MAGO, for Magnitnoye Obzhatiye, or magnetic compression) have been performed by Los Alamos National Laboratory and the All-Russian Scientific Research Institute of Experimental Physics (VNIIEF). Modeling of target plasmas must accurately predict plasma densities, temperatures, fields, and lifetime; dense plasma interactions with wall materials must be characterized. Modeling of magnetically driven imploding solid liners, for compression of target plasmas, must address issues such as Rayleigh-Taylor instability growth in the presence of material strength, and glide plane-liner interactions. Proposed experiments involving liner-on-plasma compressions to fusion conditions will require integrated target plasma and liner calculations. Detailed comparison of the modeling results with experiment will be presented.

  9. Quantitative ultrasound molecular imaging by modeling the binding kinetics of targeted contrast agent

    NASA Astrophysics Data System (ADS)

    Turco, Simona; Tardy, Isabelle; Frinking, Peter; Wijkstra, Hessel; Mischi, Massimo

    2017-03-01

    Ultrasound molecular imaging (USMI) is an emerging technique to monitor diseases at the molecular level by the use of novel targeted ultrasound contrast agents (tUCA). These consist of microbubbles functionalized with targeting ligands with high-affinity for molecular markers of specific disease processes, such as cancer-related angiogenesis. Among the molecular markers of angiogenesis, the vascular endothelial growth factor receptor 2 (VEGFR2) is recognized to play a major role. In response, the clinical-grade tUCA BR55 was recently developed, consisting of VEGFR2-targeting microbubbles which can flow through the entire circulation and accumulate where VEGFR2 is over-expressed, thus causing selective enhancement in areas of active angiogenesis. Discrimination between bound and free microbubbles is crucial to assess cancer angiogenesis. Currently, this is done non-quantitatively by looking at the late enhancement, about 10 min after injection, or by calculation of the differential targeted enhancement, requiring the application of a high-pressure ultrasound (US) burst to destroy all the microbubbles in the acoustic field and isolate the signal coming only from bound microbubbles. In this work, we propose a novel method based on mathematical modeling of the binding kinetics during the tUCA first pass, thus reducing the acquisition time and with no need for a destructive US burst. Fitting time-intensity curves measured with USMI by the proposed model enables the assessment of cancer angiogenesis at both the vascular and molecular levels. This is achieved by estimation of quantitative parameters related to the microvascular architecture and microbubble binding. The proposed method was tested in 11 prostate-tumor bearing rats by performing USMI after injection of BR55, and showed good agreement with current USMI methods. The novel information provided by the proposed method, possibly combined with the current non-quantitative methods, may bring deeper insight into

  10. First Results from the Physics-Based Forecasting-Targeted Inner Heliosphere Model Euhforia

    NASA Astrophysics Data System (ADS)

    Pomoell, J.

    2015-12-01

    In this work, we present the first results of the new physics-based forecasting-targeted inner heliosphere model Euhforia ('European heliospheric forecasting information asset') that we are developing. Euhforia consists of a coronal model and a magnetohydrodynamic (MHD) heliosphere model with CMEs. The aim of the baseline coronal model is to produce realistic plasma conditions at the interface radius r = 0.1 AU between the two models thus providing the necessary input to the time-dependent, three-dimensional MHD heliosphere model. It uses GONG synoptic line-of-sight magnetograms as input for a potential (PFSS) field extrapolation of the low-coronal magnetic field coupled to a current sheet (CS) model of the extended coronal magnetic field. The plasma variables at the interface radius are determined by employing semi-empirical considerations based on the properties of the PFSS+CS field such as the flux tube expansion factor and distance to nearest coronal hole. The heliosphere model computes the time-dependent evolution of the MHD variables from the interface radius typically up to 2 AU. Coronal mass ejections (CMEs) are injected at the interface radius using a hydrodynamic cone-like model using parameters constrained from fits to coronal imaging observations. In order to account for the modification of the heliosphere due to the presence of earlier CMEs, the standard run scenario includes CMEs launched five days prior to the start of the forecast, while the duration of the forecast extends up to seven days. In addition to presenting results of the modeling, we will highlight our on-going efforts to advance beyond the baseline in the forecasting pipeline. In particular we discuss our path towards using magnetized CMEs, application of a time-dependent coronal model as well as modeling the transport of solar energetic particles (SEPs) in the heliosphere.

  11. Stochastic model for supersymmetric particle branching process

    NASA Astrophysics Data System (ADS)

    Zhang, Yuanyuan; Chan, Aik Hui; Oh, Choo Hiap

    2017-01-01

    We develop a stochastic branching model to describe the jet evolution of supersymmetric (SUSY) particles. This model is a modified two-phase branching process, or more precisely, a two-phase simple birth process plus Poisson process. Both pure SUSY partons initiated jets and SUSY plus ordinary partons initiated jets scenarios are considered. The stochastic branching equations are established and the Multiplicity Distributions (MDs) are derived for these two scenarios. We also fit the distribution of the general case (SUSY plus ordinary partons initiated jets) with experimental data. The fitting shows the SUSY particles have not participated in branching at current collision energy yet.

  12. Site selection and directional models of deserts used for ERBE validation targets

    NASA Technical Reports Server (NTRS)

    Staylor, W. F.

    1986-01-01

    Broadband shortwave and longwave radiance measurements obtained from the Nimbus 7 Earth Radiation Budget scanner were used to develop reflectance and emittance models for the Sahara, Gibson, and Saudi Deserts. These deserts will serve as in-flight validation targets for the Earth Radiation Budget Experiment being flown on the Earth Radiation Budget Satellite and two National Oceanic and Atmospheric Administration polar satellites. The directional reflectance model derived for the deserts was a function of the sum and product of the cosines of the solar and viewing zenith angles, and thus reciprocity existed between these zenith angles. The emittance model was related by a power law of the cosine of the viewing zenith angle.

  13. Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.

    PubMed

    Klymiuk, Nikolai; Seeliger, Frank; Bohlooly-Y, Mohammad; Blutke, Andreas; Rudmann, Daniel G; Wolf, Eckhard

    2016-04-01

    Despite enormous advances in translational biomedical research, there remains a growing demand for improved animal models of human disease. This is particularly true for diseases where rodent models do not reflect the human disease phenotype. Compared to rodents, pig anatomy and physiology are more similar to humans in cardiovascular, immune, respiratory, skeletal muscle, and metabolic systems. Importantly, efficient and precise techniques for genetic engineering of pigs are now available, facilitating the creation of tailored large animal models that mimic human disease mechanisms at the molecular level. In this article, the benefits of genetically engineered pigs for basic and translational research are exemplified by a novel pig model of Duchenne muscular dystrophy and by porcine models of cystic fibrosis. Particular emphasis is given to potential advantages of using these models for efficacy and safety testing of targeted therapies, such as exon skipping and gene editing, for example, using the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated system. In general, genetically tailored pig models have the potential to bridge the gap between proof-of-concept studies in rodents and clinical trials in patients, thus supporting translational medicine.

  14. Plant microRNA-Target Interaction Identification Model Based on the Integration of Prediction Tools and Support Vector Machine

    PubMed Central

    Meng, Jun; Shi, Lin; Luan, Yushi

    2014-01-01

    Background Confident identification of microRNA-target interactions is significant for studying the function of microRNA (miRNA). Although some computational miRNA target prediction methods have been proposed for plants, results of various methods tend to be inconsistent and usually lead to more false positive. To address these issues, we developed an integrated model for identifying plant miRNA–target interactions. Results Three online miRNA target prediction toolkits and machine learning algorithms were integrated to identify and analyze Arabidopsis thaliana miRNA-target interactions. Principle component analysis (PCA) feature extraction and self-training technology were introduced to improve the performance. Results showed that the proposed model outperformed the previously existing methods. The results were validated by using degradome sequencing supported Arabidopsis thaliana miRNA-target interactions. The proposed model constructed on Arabidopsis thaliana was run over Oryza sativa and Vitis vinifera to demonstrate that our model is effective for other plant species. Conclusions The integrated model of online predictors and local PCA-SVM classifier gained credible and high quality miRNA-target interactions. The supervised learning algorithm of PCA-SVM classifier was employed in plant miRNA target identification for the first time. Its performance can be substantially improved if more experimentally proved training samples are provided. PMID:25051153

  15. Targeting blood thrombogenicity precipitates atherothrombotic events in a mouse model of plaque destabilization

    PubMed Central

    Liu, Xiaoling; Ni, Mei; Ma, Lianyue; Yang, Jianmin; Wang, Lin; Liu, Fangfang; Dong, Mei; Yang, Xiaoyan; Zhang, Mei; Lu, Huixia; Wang, Jingjing; Zhang, Cheng; Jiang, Fan; Zhang, Yun

    2015-01-01

    Although some features of plaque instability can be observed in genetically modified mouse models, atherothrombosis induction in mice has been attested to be difficult. We sought to test the hypothesis that alterations in blood thrombogenicity might have an essential role in the development of atherothrombosis in ApoE−/− mice. In a mouse model of plaque destabilization established in our laboratory, we targeted blood thrombogenicity by systemically overexpressing murine prothrombin via adenovirus-mediated gene transfer. Systemic overexpression of prothrombin increased blood thrombogenicity, and remarkably, precipitated atherothrombotic events in 70% of the animals. The affected plaques displayed features of culprit lesions as seen in human coronary arteries, including fibrous cap disruption, luminal thrombosis, and plaque hemorrhage. Treatment with aspirin and clopidogrel substantially reduced the incidence of atherothrombosis in this model. Mechanistically, increased inflammation, apoptosis and upregulation of metalloproteinases contributed to the development of plaque destabilization and atherothrombosis. As conclusions, targeting blood thrombogenicity in mice can faithfully reproduce the process of atherothrombosis as occurring in human coronary vessels. Our results suggest that blood-plaque interactions are critical in the development of atherothrombosis in mice, substantiating the argument that changes in blood coagulation status may have a determinant role in the onset of acute coronary syndrome. PMID:25959659

  16. Adolescent Weight Control: An Intervention Targeting Parent Communication and Modeling Compared With Minimal Parental Involvement

    PubMed Central

    Hadley, Wendy; Sato, Amy; Kuhl, Elizabeth; Rancourt, Diana; Oster, Danielle; Lloyd-Richardson, Elizabeth

    2015-01-01

    Objective Adolescent weight control interventions demonstrate variable findings, with inconsistent data regarding the appropriate role for parents. The current study examined the efficacy of a standard adolescent behavioral weight control (BWC) intervention that also targeted parent–adolescent communication and parental modeling of healthy behaviors (Standard Behavioral Treatment + Enhanced Parenting; SBT + EP) compared with a standard BWC intervention (SBT). Methods 49 obese adolescents (M age = 15.10; SD = 1.33; 76% female; 67.3% non-Hispanic White) and a caregiver were randomly assigned to SBT or SBT + EP. Adolescent and caregiver weight and height, parental modeling, and weight-related communication were obtained at baseline and end of the 16-week intervention. Results Significant decreases in adolescent weight and increases in parental self-monitoring were observed across both conditions. Analyses of covariance revealed a trend for greater reduction in weight and negative maternal commentary among SBT condition participants. Conclusions Contrary to hypotheses, targeting parent–adolescent communication and parental modeling did not lead to better outcomes in adolescent weight control. PMID:25294840

  17. A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

    PubMed Central

    Giotopoulos, George; van der Weyden, Louise; Osaki, Hikari; Rust, Alistair G.; Gallipoli, Paolo; Meduri, Eshwar; Horton, Sarah J.; Chan, Wai-In; Foster, Donna; Prinjha, Rab K.; Pimanda, John E.; Tenen, Daniel G.; Vassiliou, George S.; Koschmieder, Steffen; Adams, David J.

    2015-01-01

    The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective therapies for TKI-refractory CML, or after progression to blast crisis (BC), are lacking. Whereas the chronic phase of CML is dependent on BCR-ABL, additional mutations are required for progression to BC. However, the identity of these mutations and the pathways they affect are poorly understood, hampering our ability to identify therapeutic targets and improve outcomes. Here, we describe a novel mouse model that allows identification of mechanisms of BC progression in an unbiased and tractable manner, using transposon-based insertional mutagenesis on the background of chronic phase CML. Our BC model is the first to faithfully recapitulate the phenotype, cellular and molecular biology of human CML progression. We report a heterogeneous and unique pattern of insertions identifying known and novel candidate genes and demonstrate that these pathways drive disease progression and provide potential targets for novel therapeutic strategies. Our model greatly informs the biology of CML progression and provides a potent resource for the development of candidate therapies to improve the dismal outcomes in this highly aggressive disease. PMID:26304963

  18. Experimental model of transthoracic, vascular-targeted, photodynamically induced myocardial infarction

    PubMed Central

    Pokreisz, Peter; Schnitzer, Jan E.

    2013-01-01

    We describe a novel model of myocardial infarction (MI) in rats induced by percutaneous transthoracic low-energy laser-targeted photodynamic irradiation. The procedure does not require thoracotomy and represents a minimally invasive alternative to existing surgical models. Target cardiac area to be photodynamically irradiated was triangulated from the thoracic X-ray scans. The acute phase of MI was histopathologically characterized by the presence of extensive vascular occlusion, hemorrhage, loss of transversal striations, neutrophilic infiltration, and necrotic changes of cardiomyocytes. Consequently, damaged myocardium was replaced with fibrovascular and granulation tissue. The fibrotic scar in the infarcted area was detected by computer tomography imaging. Cardiac troponin I (cTnI), a specific marker of myocardial injury, was significantly elevated at 6 h (41 ± 6 ng/ml, n = 4, P < 0.05 vs. baseline) and returned to baseline after 72 h. Triphenyltetrazolium chloride staining revealed transmural anterolateral infarcts targeting 25 ± 3% of the left ventricle at day 1 with a decrease to 20 ± 3% at day 40 (n = 6 for each group, P < 0.01 vs. day 1). Electrocardiography (ECG) showed significant ST-segment elevation in the acute phase with subsequent development of a pathological Q wave and premature ventricular contractions in the chronic phase of MI. Vectorcardiogram analysis of spatiotemporal electrical signal transduction revealed changes in inscription direction, QRS loop morphology, and redistribution in quadrant areas. The photodynamically induced MI in n = 51 rats was associated with 12% total mortality. Histological findings, ECG abnormalities, and elevated cTnI levels confirmed the photosensitizer-dependent induction of MI after laser irradiation. This novel rodent model of MI might provide a platform to evaluate new diagnostic or therapeutic interventions. PMID:24213611

  19. Community Health Workers promoting physical activity: Targeting multiple levels of the Social Ecological Model

    PubMed Central

    Haughton, Jessica; Ayala, Guadalupe X.; Burke, Kari Herzog; Elder, John P.; Montañez, Jacqueline; Arredondo, Elva M.

    2015-01-01

    The effectiveness of Community Health Workers (CHWs) as health educators and health promoters among Latino populations is widely recognized. The Affordable Care Act created important opportunities to increase the role of CHWs in preventive health. This article describes the implementation of CHW-led, culturally specific, faith-based program to increase physical activity (PA) among churchgoing Latinas. The current study augments previous research by describing the recruitment, selection, training, and evaluation of CHWs for a PA intervention targeting multiple levels of the Social Ecological Model. PMID:26280587

  20. Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation

    PubMed Central

    Ibi, Daisuke; Yamada, Kiyofumi

    2015-01-01

    Increasing epidemiological evidence indicates that perinatal infection with various viral pathogens enhances the risk for several psychiatric disorders. The pathophysiological significance of astrocyte interactions with neurons and/or gut microbiomes has been reported in neurodevelopmental disorders triggered by pre- and postnatal immune insults. Recent studies with the maternal immune activation or neonatal polyriboinosinic polyribocytidylic acid models of neurodevelopmental disorders have identified various candidate molecules that could be responsible for brain dysfunction. Here, we review the functions of several candidate molecules in neurodevelopment and brain function and discuss their potential as therapeutic targets for psychiatric disorders. PMID:26633355

  1. Predicting mitochondrial targeting by small molecule xenobiotics within living cells using QSAR models.

    PubMed

    Horobin, Richard W

    2015-01-01

    Whether small molecule xenobiotics (biocides, drugs, probes, toxins) will target mitochondria in living cells can be predicted using an algorithm derived from QSAR modeling. Application of the algorithm requires the chemical structures of all ionic species of the xenobiotic compound in question to be defined, and for certain numerical structure parameters (AI, CBN, log P, pKa, and Z) to be obtained for all such species. How the chemical structures are specified, how the structure parameters are obtained or estimated, and how the algorithm is used are described in an explicit protocol.

  2. A Comparison of Fully Polarimetric X-Band ISAR Imagery of Scaled Model Tactical Targets

    DTIC Science & Technology

    2006-05-01

    scaled X- band radar data with 6-inch full-scale range resolution. In order to investigate the reproduction of X-band data using scale models, fully...polarimetric high-resolution radar signature data has been collected on several targets which include a high-fidelity in-house built 1/16th scale T72...It will be shown that the T72 data sets compare well across the three different radar platforms. It has also been found that there are persistent

  3. Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer

    PubMed Central

    Bautz, David J.; Sherpa, Ang T.

    2017-01-01

    ABSTRACT Prophylactic vaccination is typically utilized for the prevention of communicable diseases such as measles and influenza but, with the exception of vaccines to prevent cervical cancer, is not widely used as a means of preventing or reducing the incidence of cancer. Here, we utilize a peptide-based immunotherapeutic approach targeting ERBB3, a pseudo-kinase member of the EGFR/ERBB family of receptor tyrosine kinases, as a means of preventing occurrence of colon polyps. Administration of the peptide resulted in a significant decrease in the development of intestinal polyps in C57BL/6J-ApcMin mice, a model of familial adenomatous polyposis (FAP). In addition, even though they were not vaccinated, ApcMin offspring born to vaccinated females developed significantly fewer polyps than offspring born to control females. Lastly, to validate ERBB as a valid target for vaccination, we found no overt toxicity, increases in apoptosis, or morphological changes in tissues where Erbb3 was ablated in adult mice. These results indicate that prophylactic vaccination targeting ERBB3 could prevent the development of colon polyps in an at-risk patient population. PMID:28197371

  4. Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer.

    PubMed

    Jaeger, Savina; Min, Junxia; Nigsch, Florian; Camargo, Miguel; Hutz, Janna; Cornett, Allen; Cleaver, Stephen; Buckler, Alan; Jenkins, Jeremy L

    2014-06-01

    Gene-expression data are often used to infer pathways regulating transcriptional responses. For example, differentially expressed genes (DEGs) induced by compound treatment can help characterize hits from phenotypic screens, either by correlation with known drug signatures or by pathway enrichment. Pathway enrichment is, however, typically computed with DEGs rather than "upstream" nodes that are potentially causal of "downstream" changes. Here, we present graph-based models to predict causal targets from compound-microarray data. We test several approaches to traversing network topology, and show that a consensus minimum-rank score (SigNet) beat individual methods and could highly rank compound targets among all network nodes. In addition, larger, less canonical networks outperformed linear canonical interactions. Importantly, pathway enrichment using causal nodes rather than DEGs recovers relevant pathways more often. To further validate our approach, we used integrated data sets from the Cancer Genome Atlas to identify driving pathways in triple-negative breast cancer. Critical pathways were uncovered, including the epidermal growth factor receptor 2-phosphatidylinositide 3-kinase-AKT-MAPK growth pathway andATR-p53-BRCA DNA damage pathway, in addition to unexpected pathways, such as TGF-WNT cytoskeleton remodeling, IL12-induced interferon gamma production, and TNFR-IAP (inhibitor of apoptosis) apoptosis; the latter was validated by pooled small hairpin RNA profiling in cancer cells. Overall, our approach can bridge transcriptional profiles to compound targets and driving pathways in cancer.

  5. Inhibition and regression of tumors in hamster DMBA model following laser microvascular targeting

    NASA Astrophysics Data System (ADS)

    McMillan, Kathleen; Wang, Zhi; Shapshay, Stanley M.

    1998-07-01

    Vascular targeting is a recent approach to cancer therapy that aims at damaging tumor vasculature to induce tumor cell hypoxia and subsequent cell death. Squamous cell cancer arises in the superficial mucosal and cutaneous epithelial layers, and tumor microvasculature therefore may be particularly well suited for targeting by selective photothermolysis. An initial evaluation of the effect of selective eradication of microvasculature on tumor development was undertaken here using the chemically-induced hamster cheek pouch model and a 585 nm pulsed dye laser. In a first group of 6 hamsters, progression of premalignant mucosal lesions was compared between control and laser treatment groups, and laser-induced regression of established tumors was evaluated. In a second group of 12 hamsters, the number of laser treatments required to produce complete regression of tumors of the buccal mucosa was determined. The effect of the laser on tumors appearing on the skin in these animals was also investigated. These experiments showed that laser treatment inhibited tumor development and caused complete regression of established tumors 10 mm3 or smaller. Photothermal microvascular targeting may be useful in treating dyplasia and early tumors of the upper aerodigestive tract and skin, with fewer adverse sequelae than existing modalities.

  6. Understanding Laser-Imprint Effects on Plastic-Target Implosions on OMEGA with New Physics Models

    NASA Astrophysics Data System (ADS)

    Hu, S. X.; Michel, D. T.; Davis, A. K.; Betti, R.; Radha, P. B.; Campbell, E. M.; Froula, D. H.; Stoeckl, C.

    2016-10-01

    Using the state-of-the-art physics models (nonlocal thermal transport, cross-beam energy transfer, and first-principles equation of state) recently implemented in our two-dimensional hydrocode DRACO, we have performed a systematic study of laser-imprint effects on plastic-target implosions on OMEGA by both simulations and experiments. Through varying the laser picket intensity, the imploding shells were set at different adiabats ranging from α = 2 to α = 6 . As the shell adiabat α decreases, we observed: (1) the measured shell thickness at the hot spot emission becomes larger than the uniform prediction; (2) the hot-spot core emits and neutron burn starts earlier than the corresponding 1-D prediction; and (3) the measured neutron yields are significantly reduced from their 1-D designs. Most of these experimental observations are well reproduced by our DRACO simulations with laser imprints. These studies clearly identify that laser imprint is the major cause for target performance degradation of OMEGA implosions of α <= 3 . Mitigating laser imprints must be an essential effort to improve low- α target performance in direct-drive inertial confinement fusion ignition attempts. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  7. Earth Science Data and Models for Improved Targeting of Humanitarian Aid

    NASA Technical Reports Server (NTRS)

    Brown, Molly E.

    2011-01-01

    Humanitarian assistance to developing countries has long focused on countries that have political, economic and strategic interest to the United States. Recent changes in global security concerns have heightened the perception that humanitarian action is becoming increasingly politicized. This is seen to be largely driven by the 'global war on terror' along with a push by donors and the United Nations for closer integration between humanitarian action and diplomatic, military and other spheres of engagement in conflict and crisis-affected states (HPG 2010). As we enter an era of rising commodity prices and increasing uncertainty in global food production due to a changing climate, scientific data and analysis will be increasingly important to improve the targeting of humanitarian assistance. Earth science data enables appropriate humanitarian response to complex food emergencies that arise in regions outside the areas of current strategic and security focus. As the climate changes, new places will become vulnerable to food insecurity and will need emergency assistance. Earth science data and multidisciplinary models will enable an information-based comparison of need that goes beyond strategic and political considerations to identify new hotspots of food insecurity as they emerge. These analyses will improve aid targeting and timeliness while reducing strategic risk by highlighting new regions at risk of crisis in a rapidly changing world. Improved targeting with respect to timing and location could reduce cost while increasing the likelihood that those who need aid get it.

  8. Modeling and numerical analysis of a magneto-inertial fusion concept with the target created through FRC merging

    NASA Astrophysics Data System (ADS)

    Li, Chenguang; Yang, Xianjun

    2016-10-01

    The Magnetized Plasma Fusion Reactor concept is proposed as a magneto-inertial fusion approach based on the target plasma created through the collision merging of two oppositely translating field reversed configuration plasmas, which is then compressed by the imploding liner driven by the pulsed-power driver. The target creation process is described by a two-dimensional magnetohydrodynamics model, resulting in the typical target parameters. The implosion process and the fusion reaction are modeled by a simple zero-dimensional model, taking into account the alpha particle heating and the bremsstrahlung radiation loss. The compression on the target can be 2D cylindrical or 2.4D with the additive axial contraction taken into account. The dynamics of the liner compression and fusion burning are simulated and the optimum fusion gain and the associated target parameters are predicted. The scientific breakeven could be achieved at the optimized conditions.

  9. Diphoton production at the Tevatron and the LHC in the NLO approximation of the parton Reggeization approach

    NASA Astrophysics Data System (ADS)

    Nefedov, M. A.; Saleev, V. A.

    2015-11-01

    The hadroproduction of prompt isolated photon pairs at high energies is studied in the framework of the parton Reggeization approach. The real part of the NLO corrections is computed (the NLO⋆ approximation), and the procedure for the subtraction of double counting between real parton emissions in the hard-scattering matrix element and unintegrated parton distribution function is constructed for the amplitudes with Reggeized quarks in the initial state. The matrix element of the important next-to-next-to-leading-order subprocess R R →γ γ with full dependence on the transverse momenta of the initial-state Reggeized gluons is obtained. We compare obtained numerical results with diphoton spectra measured at the Tevatron and the LHC and find a good agreement of our predictions with experimental data at the high values of diphoton transverse momentum, pT, and especially at the pT larger than the diphoton invariant mass, M . In this multi-Regge kinematics region, the NLO correction is strongly suppressed, demonstrating the self-consistency of the parton Reggeization approach.

  10. Target dependence of clan model parameters at Dubna energy-chaotic pion production

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Swarnapratim; Haiduc, Maria; Neagu, Alina Tania; Firu, Elena

    2013-02-01

    A detailed study of clan model parameters and their target dependence has been carried out in the light of void probability scaling for heavy (AgBr) and light (CNO) groups of targets present in the nuclear emulsion using 22Ne (at an incident momentum of 4.1 GeV/c), 28Si (at an incident momentum of 4.5 GeV/c), 16O (at an incident momentum of 4.5 GeV/c) and 32S (at an incident momentum of 4.5 GeV/c) projectiles. The variation of scaled rap-gap probability with the single moment combination has been studied for all of the interactions. The experimental points are found to lie approximately on the NBD curve for all of the interactions, indicating a scaling behavior. According to the two-source model of particle production, in the case of 32S-AgBr interactions at 4.5 GeV/c, the pion production mechanism has been found to be almost chaotic. On the contrary, for all of the other interactions at 4.1-4.5 GeV/c, pion production is predominantly chaotic. Average clan multiplicities (\\overline N) for all of the interactions are found to increase with the increase in the pseudo-rapidity interval Δη. The values of \\overline N for the AgBr target are larger than those for the CNO target. The average number of particles per clan (\\overline n_c) increases initially with the increase in pseudo-rapidity interval. An approximate saturation of the values of \\overline n_c is observed for 22Ne and 16O projectiles around Δη = 6. With the increase in projectile size, the saturation of \\overline n_c seems to be wiped out. It can also be observed from the tables that for a particular target the average number of particles per clan (\\overline n_c) increases with the increase in the size of the projectile nucleus. A comparison with the results of the SPS data has also been presented.

  11. Application of the target fish community model to an urban river system.

    PubMed

    Meixler, Marcia S

    2011-04-01

    Several models have been developed to assess the biological integrity of aquatic systems using fish community data. One of these, the target fish community (TFC) model, has been used primarily to assess the biological integrity of larger, mainstem rivers in southern New England with basins characterized by dispersed human activities. We tested the efficacy of the TFC approach to specify the fish community in the highly urbanized Charles River watershed in eastern Massachusetts. To create a TFC for the Charles River we assembled a list of fish species that historically inhabited the Charles River watershed, identified geomorphically and zoogeographically similar reference rivers regarded as being in high quality condition, amassed fish survey data for the reference rivers, and extracted from the collections the information needed to define a TFC. We used a similarity measurement method to assess the extent to which the study river community complies with the TFC and an inference approach to summarize the manner in which the existing fish community differed from target conditions. The five most abundant species in the TFC were common shiners (34%), fallfish (17%) redbreast sunfish (11%), white suckers (8%), and American eel (7%). Three of the five species predicted to be most abundant in the TFC were scarce or absent in the existing river community. Further, the river was dominated by macrohabitat generalists (99%) while the TFC was predicted to contain 19% fluvial specialist species, 43% fluvial dependent species, and 38% macrohabitat generalist species. In addition, while the target community was dominated by fish intolerant (37%) and moderately tolerant (39%) of water quality degradation, the existing community was dominated by tolerant individuals (59%) and lacked intolerant species expected in the TFC. Similarity scores for species, habitat use specialization, and water quality degradation tolerance categories were 28%, 35% and 66%, respectively. The clear

  12. Radiotherapy planning for glioblastoma based on a tumor growth model: improving target volume delineation

    NASA Astrophysics Data System (ADS)

    Unkelbach, Jan; Menze, Bjoern H.; Konukoglu, Ender; Dittmann, Florian; Le, Matthieu; Ayache, Nicholas; Shih, Helen A.

    2014-02-01

    Glioblastoma differ from many other tumors in the sense that they grow infiltratively into the brain tissue instead of forming a solid tumor mass with a defined boundary. Only the part of the tumor with high tumor cell density can be localized through imaging directly. In contrast, brain tissue infiltrated by tumor cells at low density appears normal on current imaging modalities. In current clinical practice, a uniform margin, typically two centimeters, is applied to account for microscopic spread of disease that is not directly assessable through imaging. The current treatment planning procedure can potentially be improved by accounting for the anisotropy of tumor growth, which arises from different factors: anatomical barriers such as the falx cerebri represent boundaries for migrating tumor cells. In addition, tumor cells primarily spread in white matter and infiltrate gray matter at lower rate. We investigate the use of a phenomenological tumor growth model for treatment planning. The model is based on the Fisher-Kolmogorov equation, which formalizes these growth characteristics and estimates the spatial distribution of tumor cells in normal appearing regions of the brain. The target volume for radiotherapy planning can be defined as an isoline of the simulated tumor cell density. This paper analyzes the model with respect to implications for target volume definition and identifies its most critical components. A retrospective study involving ten glioblastoma patients treated at our institution has been performed. To illustrate the main findings of the study, a detailed case study is presented for a glioblastoma located close to the falx. In this situation, the falx represents a boundary for migrating tumor cells, whereas the corpus callosum provides a route for the tumor to spread to the contralateral hemisphere. We further discuss the sensitivity of the model with respect to the input parameters. Correct segmentation of the brain appears to be the most

  13. Noncooperative target classification using hierarchical modeling of high-range resolution radar signatures

    NASA Astrophysics Data System (ADS)

    Eom, Kie Bum

    1996-06-01

    The classification of high range resolution radar returns using multiscale features is considered. Because of the characteristics unique to radar signals, such as clutter and sensitivity to viewing angle change, classifiers using features extracted from a single scale do not meet the requirements of non-cooperative target identification (NCTI). We present a hierarchical ARMA model for modeling high range resolution radar signals in multiple scales and apply it to NCTI database containing 5000 test samples and 5000 training samples. We first show that the radar signal at a course scale follows an ARMA process if it follows an ARMA model at a finer scale. The model parameters at different scales are easily computed from the parameters at another scale. Therefore, the hierarchical model allows us to compute spectral features at the coarse scale without adding much computational burden. The multiscale spectral features at five scales are computed using the hierarchical modeling approach, and are classified by a minimum distance classifier. The multiscale classifier is applied to both poorly aligned data and better aligned data. For both data sets, about 95 percent of the radar returns were correctly classified, showing that the multiscale classifier is robust to misalignment.

  14. Comparative Analysis of Induced vs. Spontaneous Models of Autoimmune Uveitis Targeting the Interphotoreceptor Retinoid Binding Protein

    PubMed Central

    Chen, Jun; Qian, Haohua; Horai, Reiko; Chan, Chi-Chao; Falick, Yishay; Caspi, Rachel R.

    2013-01-01

    Animal models of autoimmunity to the retina mimic specific features of human uveitis, but no model by itself reproduces the full spectrum of human disease. We compared three mouse models of uveitis that target the interphotoreceptor retinoid binding protein (IRBP): (i) the “classical” model of experimental autoimmune uveitis (EAU) induced by immunization with IRBP; (ii) spontaneous uveitis in IRBP T cell receptor transgenic mice (R161H) and (iii) spontaneous uveitis in Autoimmune Regulator (AIRE)−/− mice. Disease course and severity, pathology and changes in visual function were studied using fundus imaging and histological examinations, optical coherence tomography and electroretinography. All models were on the B10.RIII background. Unlike previously reported, IRBP-induced EAU in B10.RIII mice exhibited two distinct patterns of disease depending on clinical scores developed after onset: severe monophasic with extensive destruction of the retina and rapid loss of visual signal, or lower grade with a prolonged chronic phase culminating after several months in retinal degeneration and loss of vision. R161H and AIRE−/− mice spontaneously developed chronic progressive inflammation; visual function declined gradually as retinal degeneration developed. Spontaneous uveitis in R161H mice was characterized by persistent cellular infiltrates and lymphoid aggregation, whereas AIRE−/− mice characteristically developed multi-focal infiltrates and severe choroidal inflammation. These data demonstrate variability and unique distinguishing features in the different models of uveitis, suggesting that each one can represent distinct aspects of uveitis in humans. PMID:24015215

  15. Exclusive η electroproduction at W >2 GeV with CLAS and transversity generalized parton distributions

    NASA Astrophysics Data System (ADS)

    Bedlinskiy, I.; Kubarovsky, V.; Stoler, P.; Adhikari, K. P.; Akbar, Z.; Anefalos Pereira, S.; Avakian, H.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Biselli, A. S.; Boiarinov, S.; Briscoe, W. J.; Burkert, V. D.; Cao, T.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Ciullo, G.; Clark, L.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Deur, A.; Djalali, C.; Dupre, R.; Alaoui, A. El; Fassi, L. El; Elouadrhiri, L.; Eugenio, P.; Fanchini, E.; Fedotov, G.; Fersch, R.; Filippi, A.; Fleming, J. A.; Forest, T. A.; Garçon, M.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gleason, C.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Hughes, S. M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jenkins, D.; Jiang, H.; Jo, H. S.; Joo, K.; Joosten, S.; Keller, D.; Khachatryan, G.; Khachatryan, M.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Kuhn, S. E.; Kuleshov, S. V.; Lanza, L.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Markov, N.; McKinnon, B.; Meziani, Z. E.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Movsisyan, A.; Munoz Camacho, C.; Nadel-Turonski, P.; Net, L. A.; Ni, A.; Niccolai, S.; Niculescu, G.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Peng, P.; Phelps, W.; Pisano, S.; Pogorelko, O.; Price, J. W.; Prok, Y.; Protopopescu, D.; Puckett, A. J. R.; Raue, B. A.; Ripani, M.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Saini, M. S.; Salgado, C.; Schumacher, R. A.; Sharabian, Y. G.; Skorodumina, Iu.; Smith, G. D.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tian, Ye; Torayev, B.; Turisini, M.; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Yurov, M.; Zachariou, N.; Zhang, J.; Zonta, I.; CLAS Collaboration

    2017-03-01

    The cross section of the exclusive η electroproduction reaction e p →e'p'η was measured at Jefferson Laboratory with a 5.75 GeV electron beam and the CLAS detector. Differential cross sections d4σ /d t d Q2d xBd ϕη and structure functions σU=σT+ɛ σL,σT T , and σL T, as functions of t , were obtained over a wide range of Q2 and xB. The η structure functions are compared with those previously measured for π0 at the same kinematics. At low t , both π0 and η are described reasonably well by generalized parton distributions (GPDs) in which chiral-odd transversity GPDs are dominant. The π0 and η data, when taken together, can facilitate the flavor decomposition of the transversity GPDs.

  16. Analytical Expressions for the Hard-Scattering Production of Massive Partons

    SciTech Connect

    Wong, Cheuk-Yin

    2016-01-01

    We obtain explicit expressions for the two-particle differential cross section $E_c E_\\kappa d\\sigma (AB \\to c\\kappa X) /d\\bb c d \\bb \\kappa$ and the two-particle angular correlation function \\break $d\\sigma(AB$$ \\to$$ c\\kappa X)/d\\Delta \\phi \\, d\\Delta y$ in the hard-scattering production of massive partons in order to exhibit the ``ridge" structure on the away side in the hard-scattering process. The single-particle production cross section $d\\sigma(AB \\to cX) /dy_c c_T dc_T $ is also obtained and compared with the ALICE experimental data for charm production in $pp$ collisions at 7 TeV at LHC.

  17. Prompt-photon plus jet associated photoproduction at HERA in the parton Reggeization approach

    NASA Astrophysics Data System (ADS)

    Kniehl, B. A.; Nefedov, M. A.; Saleev, V. A.

    2014-06-01

    We study the photoproduction of isolated prompt photons associated with hadron jets in the framework of the parton Reggeization approach. The cross section distributions in the transverse energies and pseudorapidities of the prompt photon and the jet as well as the azimuthal-decorrelation variables measured by the H1 and ZEUS collaborations at DESY HERA are nicely described by our predictions. The main improvements with respect to previous studies in the kT-factorization framework include the application of the Reggeized-quark formalism, the generation of exactly gauge-invariant amplitudes with off-shell initial-state quarks, and the exact treatment of the γR→γg box contribution with off-shell initial-state gluons.

  18. Heavy quarkonium production at collider energies: Partonic cross section and polarization

    SciTech Connect

    Qiu, Jian -Wei; Kang, Zhong -Bo; Ma, Yan -Qing; Sterman, George

    2015-01-27

    We calculate the O(α³s) short-distance, QCD collinear-factorized coefficient functions for all partonic channels that include the production of a heavy quark pair at short distances. Thus, this provides the first power correction to the collinear-factorized inclusive hadronic production of heavy quarkonia at large transverse momentum, pT, including the full leading-order perturbative contributions to the production of heavy quark pairs in all color and spin states employed in NRQCD treatments of this process. We discuss the role of the first power correction in the production rates and the polarizations of heavy quarkonia in high-energy hadronic collisions. The consistency of QCD collinear factorization and nonrelativistic QCD factorization applied to heavy quarkonium production is also discussed.

  19. nCTEQ15 - Global analysis of nuclear parton distributions with uncertainties in the CTEQ framework

    SciTech Connect

    Kovarik, K.; Kusina, A.; Clark, D. B.; Keppel, C.; Lyonnet, F.; Morfin, J. G.; Olness, F. I.; Owens, J. F.; Schienbein, I.

    2016-04-28

    We present the new nCTEQ15 set of nuclear parton distribution functions with uncertainties. This fit extends the CTEQ proton PDFs to include the nuclear dependence using data on nuclei all the way up to 208Pb. The uncertainties are determined using the Hessian method with an optimal rescaling of the eigenvectors to accurately represent the uncertainties for the chosen tolerance criteria. In addition to the Deep Inelastic Scattering (DIS) and Drell-Yan (DY) processes, we also include inclusive pion production data from RHIC to help constrain the nuclear gluon PDF. Here, we investigate the correlation of the data sets with specific nPDF flavor components, and asses the impact of individual experiments. We also provide comparisons of the nCTEQ15 set with recent fits from other groups.

  20. Iterative Monte Carlo analysis of spin-dependent parton distributions

    DOE PAGES

    Sato, Nobuo; Melnitchouk, Wally; Kuhn, Sebastian E.; ...

    2016-04-05

    We present a comprehensive new global QCD analysis of polarized inclusive deep-inelastic scattering, including the latest high-precision data on longitudinal and transverse polarization asymmetries from Jefferson Lab and elsewhere. The analysis is performed using a new iterative Monte Carlo fitting technique which generates stable fits to polarized parton distribution functions (PDFs) with statistically rigorous uncertainties. Inclusion of the Jefferson Lab data leads to a reduction in the PDF errors for the valence and sea quarks, as well as in the gluon polarization uncertainty at x ≳ 0.1. Furthermore, the study also provides the first determination of the flavor-separated twist-3 PDFsmore » and the d2 moment of the nucleon within a global PDF analysis.« less

  1. Iterative Monte Carlo analysis of spin-dependent parton distributions

    SciTech Connect

    Sato, Nobuo; Melnitchouk, Wally; Kuhn, Sebastian E.; Ethier, Jacob J.; Accardi, Alberto

    2016-04-05

    We present a comprehensive new global QCD analysis of polarized inclusive deep-inelastic scattering, including the latest high-precision data on longitudinal and transverse polarization asymmetries from Jefferson Lab and elsewhere. The analysis is performed using a new iterative Monte Carlo fitting technique which generates stable fits to polarized parton distribution functions (PDFs) with statistically rigorous uncertainties. Inclusion of the Jefferson Lab data leads to a reduction in the PDF errors for the valence and sea quarks, as well as in the gluon polarization uncertainty at x ≳ 0.1. Furthermore, the study also provides the first determination of the flavor-separated twist-3 PDFs and the d2 moment of the nucleon within a global PDF analysis.

  2. Heavy quarkonium production at collider energies: Partonic cross section and polarization

    DOE PAGES

    Qiu, Jian -Wei; Kang, Zhong -Bo; Ma, Yan -Qing; ...

    2015-01-27

    We calculate the O(α³s) short-distance, QCD collinear-factorized coefficient functions for all partonic channels that include the production of a heavy quark pair at short distances. Thus, this provides the first power correction to the collinear-factorized inclusive hadronic production of heavy quarkonia at large transverse momentum, pT, including the full leading-order perturbative contributions to the production of heavy quark pairs in all color and spin states employed in NRQCD treatments of this process. We discuss the role of the first power correction in the production rates and the polarizations of heavy quarkonia in high-energy hadronic collisions. The consistency of QCD collinearmore » factorization and nonrelativistic QCD factorization applied to heavy quarkonium production is also discussed.« less

  3. Exclusive η electroproduction at W>2 GeV with CLAS and transversity generalized parton distributions

    DOE PAGES

    Bedlinskiy, I.; Kubarovsky, V.; Stoler, P.; ...

    2017-03-10

    The cross section of the exclusive η electroproduction reaction ep → e'p'η was measured at Jefferson Laboratory with a 5.75 GeV electron beam and the CLAS detector. Differential cross sections d4σ/dtdQ2dxBdΦη and structure functions σU = σT + εσL, σTT, and σLT, as functions of t, were obtained over a wide range of Q2 and xB. The η structure functions are compared with those previously measured for π0 at the same kinematics. At low t, both π0 and η are described reasonably well by generalized parton distributions (GPDs) in which chiral-odd transversity GPDs are dominant. As a result, the π0more » and η data, when taken together, can facilitate the flavor decomposition of the transversity GPDs.« less

  4. Parton Energy Loss and Momentum Broadening at NLO in High Temperature QCD Plasmas

    NASA Astrophysics Data System (ADS)

    Ghiglieri, Jacopo; Teaney, Derek

    We present an overview of a perturbative-kinetic approach to jet propagation, energy loss, and momentum broadening in a high temperature quark-gluon plasma. The leading-order kinetic equations describe the interactions between energetic jet-particles and a non-abelian plasma, consisting of on-shell thermal excitations and soft gluonic fields. These interactions include 2 ↔ 2 scatterings, collinear bremsstrahlung, and drag and momentum diffusion. We show how the contribution from the soft gluonic fields can be factorized into a set of Wilson line correlators on the light-cone. We review recent field-theoretical developments, rooted in the causal properties of these correlators, which simplify the calculation of the appropriate Wilson lines in thermal field theory. With these simplifications lattice measurements of transverse momentum broadening have become possible, and the kinetic equations describing parton transport have been extended to next-to-leading order in the coupling g.

  5. Parton energy loss and momentum broadening at NLO in high temperature QCD plasmas

    NASA Astrophysics Data System (ADS)

    Ghiglieri, Jacopo; Teaney, Derek

    2015-10-01

    We present an overview of a perturbative-kinetic approach to jet propagation, energy loss, and momentum broadening in a high temperature quark-gluon plasma. The leading-order kinetic equations describe the interactions between energetic jet-particles and a non-abelian plasma, consisting of on-shell thermal excitations and soft gluonic fields. These interactions include ↔ scatterings, collinear bremsstrahlung, and drag and momentum diffusion. We show how the contribution from the soft gluonic fields can be factorized into a set of Wilson line correlators on the light-cone. We review recent field-theoretical developments, rooted in the causal properties of these correlators, which simplify the calculation of the appropriate Wilson lines in thermal field theory. With these simplifications lattice measurements of transverse momentum broadening have become possible, and the kinetic equations describing parton transport have been extended to next-to-leading order in the coupling g.

  6. Agreement of neutrino deep inelastic scattering data with global fits of parton distributions.

    PubMed

    Paukkunen, Hannu; Salgado, Carlos A

    2013-05-24

    The compatibility of neutrino-nucleus deep inelastic scattering data within the universal, factorizable nuclear parton distribution functions has been studied independently by several groups in the past few years. The conclusions are contradictory, ranging from a violation of the universality up to a good agreement, most of the controversy originating from the use of the neutrino-nucleus data from the NuTeV Collaboration. Here, we pay attention to non-negligible differences in the absolute normalization between different neutrino data sets. We find that such variations are large enough to prevent a tensionless fit to all data simultaneously and could therefore misleadingly point towards nonuniversal nuclear effects. We propose a concrete method to deal with the absolute normalization and show that an agreement between independent neutrino data sets is established.

  7. nCTEQ15 - Global analysis of nuclear parton distributions with uncertainties in the CTEQ framework

    DOE PAGES

    Kovarik, K.; Kusina, A.; Jezo, T.; ...

    2016-04-28

    We present the new nCTEQ15 set of nuclear parton distribution functions with uncertainties. This fit extends the CTEQ proton PDFs to include the nuclear dependence using data on nuclei all the way up to 208Pb. The uncertainties are determined using the Hessian method with an optimal rescaling of the eigenvectors to accurately represent the uncertainties for the chosen tolerance criteria. In addition to the Deep Inelastic Scattering (DIS) and Drell-Yan (DY) processes, we also include inclusive pion production data from RHIC to help constrain the nuclear gluon PDF. Here, we investigate the correlation of the data sets with specific nPDFmore » flavor components, and asses the impact of individual experiments. We also provide comparisons of the nCTEQ15 set with recent fits from other groups.« less

  8. BEAM ON TARGET MODEL Produces All Gamma Ray Burst Phenomena Including Afterglow

    NASA Astrophysics Data System (ADS)

    Greyber, H.

    2000-12-01

    While one must applaud the splendid research by L. Piro et al and L. Amati et al reported in SCIENCE recently, one must question, as M. Rees and S. Woolsey have done, their conclusion that a ``supranova model" is the only explanation for these new X-ray observations. In fact L. Piro was quoted as saying, ``Our data helps rule out the scenario where two neutron stars or black holes collide. We think GRBs result from something similar to a supernova explosion, but much more powerful." A relatively unknown physical model for GRBs, Greyber's Beam On Target model (BOT), dating back to the first CGRO observations, can plausibly explain the iron emission lines observed for GRB991216, and also the mass of the dense medium within a light-day of the GRB being roughly equivalent to at least one-tenth solar mass, as well as the initial shedding of material followed by the GRB event. When a galaxy forms under gravitational collapse in the presence of a primordial magnetic field, Mestel and Strittmatter demonstrated that, for finite Ohmic diffusion, a growing equatorial current loop is formed. Even if this stable ``Storage Ring" has only 10exp-9 of the total energy released during a typical galaxy's formation, the relativistic beam can possess 10exp58 ergs. The GRB ``fireball" occurs when a target star races across the powerful beam, blowing off target material as a hot, rapidly expanding plasma cloud, simulating an explosion. Since currents in space are known to be sometimes filamentary, sharp millisecond spikes can be expected in some GRBs. Proton and alpha particle nuclear reactions produce a gamma ray beam. Beam particles impinging on denser cloud material create an electromagnetic shower, producing X-ray, optical and radio radiation. Since the Storage Ring has an intense magnetic field around it, synchrotron radiation is expected. The beam, striking a highly evolved massive target star, produces the iron emission lines. H. D. Greyber, in ``After the Dark Ages:When Galaxies

  9. Functional coverage of the human genome by existing structures, structural genomics targets, and homology models.

    PubMed

    Xie, Lei; Bourne, Philip E

    2005-08-01

    The bias in protein structure and function space resulting from experimental limitations and targeting of particular functional classes of proteins by structural biologists has long been recognized, but never continuously quantified. Using the Enzyme Commission and the Gene Ontology classifications as a reference frame, and integrating structure data from the Protein Data Bank (PDB), target sequences from the structural genomics projects, structure homology derived from the SUPERFAMILY database, and genome annotations from Ensembl and NCBI, we provide a quantified view, both at the domain and whole-protein levels, of the current and projected coverage of protein structure and function space relative to the human genome. Protein structures currently provide at least one domain that covers 37% of the functional classes identified in the genome; whole structure coverage exists for 25% of the genome. If all the structural genomics targets were solved (twice the current number of structures in the PDB), it is estimated that structures of one domain would cover 69% of the functional classes identified and complete structure coverage would be 44%. Homology models from existing experimental structures extend the 37% coverage to 56% of the genome as single domains and 25% to 31% for complete structures. Coverage from homology models is not evenly distributed by protein family, reflecting differing degrees of sequence and structure divergence within families. While these data provide coverage, conversely, they also systematically highlight functional classes of proteins for which structures should be determined. Current key functional families without structure representation are highlighted here; updated information on the "most wanted list" that should be solved is available on a weekly basis from http://function.rcsb.org:8080/pdb/function_distribution/index.html.

  10. Application of the target decomposition theorem to a polarimetric random media model

    NASA Technical Reports Server (NTRS)

    Saatchi, Sasan S.; Vanzyl, Jakob J.

    1993-01-01

    With advances in polarimetric radar measurements of land surfaces, the need for understanding the underlying scattering mechanisms and dominant target features has become the focus of many studies. In particular, the maximum use of the polarimetric information to identify and/or separate parameters related to the surface features such as vegetation thickness, structure, water content, and soil surface characteristics will enhance the possibility of using polarimetric radars for monitoring the earth's surface from space. In this paper, Cloude's decomposition theorem is applied to a polarimetric random media model to simulate the radar measurements of vegetated canopies. The vegetated canopies are modeled as a three layer discrete random medium with leaves and branches in the first layer, tree trunks in the second layer, and a half space of homogeneous ground with rough interface as the bottom layer. The distorted born approximation (DBA) has been used to compute full Mueller matrix of the canopy, using canonical dielectric objects such as thin discs and cylinders as leaves, branches, and trunks, respectively. The Mueller matrix and the derived covariance matrix contain information on the second order statistics of radar signals at various polarizations from the canopy. To decompose the covariance matrix to its constituent targets, the eigenvalues and eigenvectors of the covariance matrix are computed in terms of the physical parameters of the canopy. In addition, each eigenvector explicitly shows the scattering mechanisms such as odd and even reflections in the canopy. Cloude's decomposition theorem is applied using the Pauli spin matrices as a basis and an expression for the degree of disorder or the entropy for the vegetated surface is found. Then, the physical parameters estimated from in situ measurements are used in the random media to obtain realistic covariance matrices. As a result, the sensitivity of the eigenvalue spectrums and the coefficients resulting

  11. Thermal modeling of step-out targets at the Soda Lake geothermal field, Churchill County, Nevada

    NASA Astrophysics Data System (ADS)

    Dingwall, Ryan Kenneth

    Temperature data at the Soda Lake geothermal field in the southeastern Carson Sink, Nevada, highlight an intense thermal anomaly. The geothermal field produces roughly 11 MWe from two power producing facilities which are rated to 23 MWe. The low output is attributed to the inability to locate and produce sufficient volumes of fluid at adequate temperature. Additionally, the current producing area has experienced declining production temperatures over its 40 year history. Two step-out targets adjacent to the main field have been identified that have the potential to increase production and extend the life of the field. Though shallow temperatures in the two subsidiary areas are significantly less than those found within the main anomaly, measurements in deeper wells (>1,000 m) show that temperatures viable for utilization are present. High-pass filtering of the available complete Bouguer gravity data indicates that geothermal flow is present within the shallow sediments of the two subsidiary areas. Significant faulting is observed in the seismic data in both of the subsidiary areas. These structures are highlighted in the seismic similarity attribute calculated as part of this study. One possible conceptual model for the geothermal system(s) at the step-out targets indicated upflow along these faults from depth. In order to test this hypothesis, three-dimensional computer models were constructed in order to observe the temperatures that would result from geothermal flow along the observed fault planes. Results indicate that the observed faults are viable hosts for the geothermal system(s) in the step-out areas. Subsequently, these faults are proposed as targets for future exploration focus and step-out drilling.

  12. Incidence Rate of Prediabetes Progression to Diabetes: Modeling an Optimum Target Group for Intervention.

    PubMed

    DeJesus, Ramona S; Radecki Breitkopf, Carmen; Rutten, Lila J; Jacobson, Debra J; Wilson, Patrick M; St Sauver, Jennifer

    2016-09-30

    Thirty-seven percent of US adults have prediabetes. Various interventions can delay diabetes progression; however, the optimum target group for risk reduction is uncertain. This study estimated rate of progression to diabetes at 1 and 5 years among a cohort of patients from 3 primary care clinics and modeled the potential magnitude in diabetes incidence risk reduction of an intervention program among specific subgroups. Records of 106,821 empaneled patients in 2005 were reviewed. Generalized population attributable risk (PAR) statistics were calculated to estimate the impact of reducing fasting blood glucose on diabetes progression. Multiple intervention effects (varying levels of glucose reduction along with multiple adherence rates) were examined for those with baseline glucose from 110 to 119 mg/dL and ≥120 mg/dL. Ten percent of patients (n = 10,796) met criteria for prediabetes. The 1- and 5-year diabetes incidence rate was 38.6 and 40.24 per 1000 person-years, respectively. Age and obesity were independent predictors of increased progression rate. The generalized PAR for a 10-point reduction in the 110-119 mg/dL subgroup with 25% adherence was 7.6%. The generalized PAR for similar percent reduction and adherence level in patients with baseline glucose of ≥120 mg/dL was only 3.0%. Rate of progression to diabetes increased over time and with associated independent risk factors. Greater risk reduction in diabetes progression within the target population can be achieved when the intervention is successful in those with baseline glucose of 110-119 mg/dL. Modeling an optimum target group for a diabetes prevention intervention offers a novel and useful guide to planning and allocating resources in population health management.

  13. Evaluation of TorsinA as a target for Parkinson disease therapy in mouse models.

    PubMed

    Li, Xinru; Lee, Jenny; Parsons, Dee; Janaurajs, Karen; Standaert, David G

    2012-01-01

    Parkinson disease (PD) is a common and disabling disorder. No current therapy can slow or reverse disease progression. An important aspect of research in this field is target validation, a systematic approach to evaluating the likelihood that modification of a certain molecule, mechanism or biological pathway may be useful for the development of pharmacological or molecular treatments for the disease. TorsinA, a member of the AAA+ family of chaperone proteins, has been proposed as a potential target of neuroprotective therapy. TorsinA is found in Lewy bodies in human PD, and can suppress toxicity in cellular and invertebrate models of PD. Here, we evaluated the neuroprotective properties of torsinA in mouse models of PD based on intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as recombinant adeno associated virus (rAAV) induced overexpression of alpha-synuclein (α-syn). Using either transgenic mice with overexpression of human torsinA (hWT mice) or mice in which torsinA expression was induced using an rAAV vector, we found no evidence for protection against acute MPTP intoxication. Similarly, genetic deletion of the endogenous mouse gene for torsinA (Dyt1) using an rAAV delivered Cre recombinase did not enhance the vulnerability of dopaminergic neurons to MPTP. Overexpression of α-syn using rAAV in the mouse substantia nigra lead to a loss of TH positive neurons six months after administration, and no difference in the degree of loss was observed between transgenic animals expressing forms of torsinA and wild type controls. Collectively, we did not observe evidence for a protective effect of torsinA in the mouse models we examined. Each of these models has limitations, and there is no single model with established predictive value with respect to the human disease. Nevertheless, these data do seem to support the view that torsinA is unlikely to be successfully translated as a target of therapy for human PD.

  14. A Supervisor-Targeted Implementation Approach to Promote System Change: The R(3) Model.

    PubMed

    Saldana, Lisa; Chamberlain, Patricia; Chapman, Jason

    2016-11-01

    Opportunities to evaluate strategies to create system-wide change in the child welfare system (CWS) and the resulting public health impact are rare. Leveraging a real-world, system-initiated effort to infuse the use of evidence-based principles throughout a CWS workforce, a pilot of the R(3) model and supervisor-targeted implementation approach is described. The development of R(3) and its associated fidelity monitoring was a collaboration between the CWS and model developers. Outcomes demonstrate implementation feasibility, strong fidelity scale measurement properties, improved supervisor fidelity over time, and the acceptability and perception of positive change by agency leadership. The value of system-initiated collaborations is discussed.

  15. Background first- and second-order modeling for point target detection.

    PubMed

    Genin, Laure; Champagnat, Frédéric; Le Besnerais, Guy

    2012-11-01

    This paper deals with point target detection in nonstationary backgrounds such as cloud scenes in aerial or satellite imaging. We propose an original spatial detection method based on first- and second-order modeling (i.e., mean and covariance) of local background statistics. We first show that state-of-the-art nonlocal denoising methods can be adapted with minimal effort to yield edge-preserving background mean estimates. These mean estimates lead to very efficient background suppression (BS) detection. However, we propose that BS be followed by a matched filter based on an estimate of the local spatial covariance matrix. The identification of these matrices derives from a robust classification of pixels in classes with homogeneous second-order statistics based on a Gaussian mixture model. The efficiency of the proposed approaches is demonstrated by evaluation on two cloudy sky background databases.

  16. Modeling the interaction of high power ion or electron beams with solid target materials

    SciTech Connect

    Hassanein, A.M.

    1983-11-01

    Intense energy deposition on first wall materials and other components as a result of plasma disruptions in magnetic fusion devices are expected to cause melting and vaporization of these materials. The exact amount of vaporization losses and melt layer thickness are very important to fusion reactor design and lifetime. Experiments using ion or electron beams to simulate the disruption effects have different environments than the actual disruption conditions in fusion reactors. A model has been developed to accurately simulate the beam-target interactions so that the results from such experiments can be meaningful and useful to reactor design. This model includes a two dimensional solution of the heat conduction equation with moving boundaries. It is found that the vaporization and melting of the sample strongly depends on the characteristics of the beam spatial distribution, beam diameter, and on the power-time variation of the beam.

  17. Investigation of magnetic nanoparticle targeting in a simplified model of small vessel aneurysm

    NASA Astrophysics Data System (ADS)

    Mirzababaei, S. N.; Gorji, Tahereh B.; Baou, M.; Gorji-Bandpy, M.; Fatouraee, Nasser

    2017-03-01

    An in simulacra study was conducted to investigate the capture efficiency (CE) of magnetic nanoparticles (MNPs) in aneurysm model, under the effect of a bipolar permanent magnetic system positioned at the vicinity of the model vessel. The bipolar magnetic system with an active space of 9 cm was designed by FEMM software. The MNPs were magnetite nanoparticles synthesized by the hydrothermal method which were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscope and magnetometer measurements. Ferrofluid velocity, magnetic field strength, and aneurysm volume all proved to be important parameters which affect the capturing of MNPs. Overall, the results of this in simulacra study confirmed the effectiveness of magnetic targeting for possible aneurysm embolization.

  18. Effects of target routing model on the occurrence of extreme events in complex networks

    NASA Astrophysics Data System (ADS)

    Ling, Xiang; Hu, Mao-Bin; Ding, Jian-Xun; Shi, Qing; Jiang, Rui

    2013-04-01

    This paper investigates the effect of routing protocol on the occurrence of extreme events (EE) in complex networks, as an extension of [V. Kishore, M.S. Santhanam, R.E. Amritkar, Phys. Rev. Lett. 106, 188701 (2011)]. The target routing model [W.X. Wang, B.H. Wang, C.Y. Yin, Y.B. Xie, T. Zhou, Phys. Rev. E 73, 026111 (2006)] is considered. In the model, a tunable power parameter α controls the packets' preference of forwarding direction. We derive exact expressions for the stationary distribution probability of packets and estimate the occurrence probability of EE on the nodes. The occurrence of EE strongly depends on the routing parameter. For Barabási-Albert scale-free network, Erdös-Rényi random network and Newman-Watts small-world network, it is shown that the minimal occurrence of EE is achieved at α = -1.

  19. The 727 airplane target thrust reverser static performance model test for refanned JT8D engines

    NASA Technical Reports Server (NTRS)

    Chow, C. T. P.; Atkey, E. N.

    1974-01-01

    The results of a scale model static performance test of target thrust reverser configurations for the Pratt and Whitney Aircraft JT8D-100 series engine are presented. The objective of the test was to select a series of suitable candidate reverser configurations for the subsequent airplane model wind tunnel ingestion and flight controls tests. Test results indicate that adequate reverse thrust performance with compatible engine airflow match is achievable for the selected configurations. Tapering of the lips results in loss of performance and only minimal flow directivity. Door pressure surveys were conducted on a selected number of lip and fence configurations to obtain data to support the design of the thrust reverser system.

  20. Boolean Network Model for Cancer Pathways: Predicting Carcinogenesis and Targeted Therapy Outcomes

    PubMed Central

    Fumiã, Herman F.; Martins, Marcelo L.

    2013-01-01

    A Boolean dynamical system integrating the main signaling pathways involved in cancer is constructed based on the currently known protein-protein interaction network. This system exhibits stationary protein activation patterns – attractors – dependent on the cell's microenvironment. These dynamical attractors were determined through simulations and their stabilities against mutations were tested. In a higher hierarchical level, it was possible to group the network attractors into distinct cell phenotypes and determine driver mutations that promote phenotypic transitions. We find that driver nodes are not necessarily central in the network topology, but at least they are direct regulators of central components towards which converge or through which crosstalk distinct cancer signaling pathways. The predicted drivers are in agreement with those pointed out by diverse census of cancer genes recently performed for several human cancers. Furthermore, our results demonstrate that cell phenotypes can evolve towards full malignancy through distinct sequences of accumulated mutations. In particular, the network model supports routes of carcinogenesis known for some tumor types. Finally, the Boolean network model is employed to evaluate the outcome of molecularly targeted cancer therapies. The major find is that monotherapies were additive in their effects and that the association of targeted drugs is necessary for cancer eradication. PMID:23922675