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Sample records for pathology information kit

  1. Project Information Packages Kit.

    ERIC Educational Resources Information Center

    RMC Research Corp., Mountain View, CA.

    Presented are an overview booklet, a project selection guide, and six Project Information Packages (PIPs) for six exemplary projects serving underachieving students in grades k through 9. The overview booklet outlines the PIP projects and includes a chart of major project features. A project selection guide reviews the PIP history, PIP contents,…

  2. Networked Information Resources. SPEC Kit 253.

    ERIC Educational Resources Information Center

    Bleiler, Richard, Comp.; Plum, Terry, Comp.

    1999-01-01

    This SPEC Kit, published six times per year, examines how Association of Research Libraries (ARL) libraries have structured themselves to identify networked information resources in the market, to evaluate them for purchase, to make purchasing decisions, to publicize them, and to assess their continued utility. In the summer of 1999, the survey…

  3. Networked Information Resources. SPEC Kit 253.

    ERIC Educational Resources Information Center

    Bleiler, Richard, Comp.; Plum, Terry, Comp.

    1999-01-01

    This SPEC Kit, published six times per year, examines how Association of Research Libraries (ARL) libraries have structured themselves to identify networked information resources in the market, to evaluate them for purchase, to make purchasing decisions, to publicize them, and to assess their continued utility. In the summer of 1999, the survey…

  4. Information Technology Policies. SPEC Kit 218.

    ERIC Educational Resources Information Center

    Leung, Shirley; Bisom, Diane

    The objectives of this survey were: to gather information on the development of institutional information technology policies and guidelines for responsible computing and use of electronic information; to identify the scope of such policies and guidelines; and to determine the role of the library in the development and/or use of the policies and…

  5. Anatomic pathology laboratory information systems: a review.

    PubMed

    Park, Seung Lyung; Pantanowitz, Liron; Sharma, Gaurav; Parwani, Anil Vasdev

    2012-03-01

    The modern anatomic pathology laboratory depends on a reliable information infrastructure to register specimens, record gross and microscopic findings, regulate laboratory workflow, formulate and sign out report(s), disseminate them to the intended recipients across the whole health system, and support quality assurance measures. This infrastructure is provided by the Anatomical Pathology Laboratory Information Systems (APLIS), which have evolved over decades and now are beginning to support evolving technologies like asset tracking and digital imaging. As digital pathology transitions from "the way of the future" to "the way of the present," the APLIS continues to be one of the key effective enablers of the scope and practice of pathology. In this review, we discuss the evolution, necessary components, architecture and functionality of the APLIS that are crucial to today's practicing pathologist and address the demands of emerging trends on the future APLIS.

  6. Digital pathology and anatomic pathology laboratory information system integration to support digital pathology sign-out.

    PubMed

    Guo, Huazhang; Birsa, Joe; Farahani, Navid; Hartman, Douglas J; Piccoli, Anthony; O'Leary, Matthew; McHugh, Jeffrey; Nyman, Mark; Stratman, Curtis; Kvarnstrom, Vanja; Yousem, Samuel; Pantanowitz, Liron

    2016-01-01

    The adoption of digital pathology offers benefits over labor-intensive, time-consuming, and error-prone manual processes. However, because most workflow and laboratory transactions are centered around the anatomical pathology laboratory information system (APLIS), adoption of digital pathology ideally requires integration with the APLIS. A digital pathology system (DPS) integrated with the APLIS was recently implemented at our institution for diagnostic use. We demonstrate how such integration supports digital workflow to sign-out anatomical pathology cases. Workflow begins when pathology cases get accessioned into the APLIS (CoPathPlus). Glass slides from these cases are then digitized (Omnyx VL120 scanner) and automatically uploaded into the DPS (Omnyx(®) Integrated Digital Pathology (IDP) software v.1.3). The APLIS transmits case data to the DPS via a publishing web service. The DPS associates scanned images with the correct case using barcode labels on slides and information received from the APLIS. When pathologists remotely open a case in the DPS, additional information (e.g. gross pathology details, prior cases) gets retrieved from the APLIS through a query web service. Following validation of this integration, pathologists at our institution have signed out more than 1000 surgical pathology cases in a production environment. Integration between the APLIS and DPS enabled pathologists to review digital slides while simultaneously having access to pertinent case metadata. The introduction of a digital workflow eliminated costly manual tasks involving matching of glass slides and avoided delays waiting for glass slides to be delivered. Integrating the DPS and APLIS were instrumental for successfully implementing a digital solution at our institution for pathology sign-out. The integration streamlined our digital sign-out workflow, diminished the potential for human error related to matching slides, and improved the sign-out experience for pathologists.

  7. Digital pathology and anatomic pathology laboratory information system integration to support digital pathology sign-out

    PubMed Central

    Guo, Huazhang; Birsa, Joe; Farahani, Navid; Hartman, Douglas J.; Piccoli, Anthony; O’Leary, Matthew; McHugh, Jeffrey; Nyman, Mark; Stratman, Curtis; Kvarnstrom, Vanja; Yousem, Samuel; Pantanowitz, Liron

    2016-01-01

    Background: The adoption of digital pathology offers benefits over labor-intensive, time-consuming, and error-prone manual processes. However, because most workflow and laboratory transactions are centered around the anatomical pathology laboratory information system (APLIS), adoption of digital pathology ideally requires integration with the APLIS. A digital pathology system (DPS) integrated with the APLIS was recently implemented at our institution for diagnostic use. We demonstrate how such integration supports digital workflow to sign-out anatomical pathology cases. Methods: Workflow begins when pathology cases get accessioned into the APLIS (CoPathPlus). Glass slides from these cases are then digitized (Omnyx VL120 scanner) and automatically uploaded into the DPS (Omnyx® Integrated Digital Pathology (IDP) software v.1.3). The APLIS transmits case data to the DPS via a publishing web service. The DPS associates scanned images with the correct case using barcode labels on slides and information received from the APLIS. When pathologists remotely open a case in the DPS, additional information (e.g. gross pathology details, prior cases) gets retrieved from the APLIS through a query web service. Results: Following validation of this integration, pathologists at our institution have signed out more than 1000 surgical pathology cases in a production environment. Integration between the APLIS and DPS enabled pathologists to review digital slides while simultaneously having access to pertinent case metadata. The introduction of a digital workflow eliminated costly manual tasks involving matching of glass slides and avoided delays waiting for glass slides to be delivered. Conclusion: Integrating the DPS and APLIS were instrumental for successfully implementing a digital solution at our institution for pathology sign-out. The integration streamlined our digital sign-out workflow, diminished the potential for human error related to matching slides, and improved the sign

  8. Scholarly Information Centers in ARL Libraries. SPEC Kit 175.

    ERIC Educational Resources Information Center

    Allen, Nancy, Comp.; Godden, Irene, Comp.

    Noting that the rapid evolution of telecommunications technology, the relentless advancement of computing capabilities, and the seemingly endless proliferation of electronic data have had a profound impact on research libraries, this Systems and Procedures Exchange Center (SPEC) kit explores the extent to which these technologies have come…

  9. In phyllodes tumour of the breast expression of c-kit but not of ALDH1A1 is associated with adverse clinico-pathological features.

    PubMed

    Chougule, Abhijit; Bal, Amanjit; Das, Ashim; Kohli, Pavneet Singh; Singh, Gurpreet

    2016-12-01

    Attempts at identification of an ideal prognostic/predictive biomarker in phyllodes tumour (PT) have not been fruitful so far. Studies evaluating c-kit expression in PT have shown contradictory results. Recently aldehyde dehydrogenase 1A1 (ALDH1A1) was proposed as a stem cell marker for malignant PT but its expression has not been studied in benign and borderline tumours. We aimed to evaluate expression and prognostic significance of c-kit and ALDH1A1 in different grades of PT. Epithelial and stromal c-kit and ALDH1A1 expression were studied in 104 PT cases (86 primary and 18 recurrent tumours) and compared with different clinico-pathological features and recurrence rates. Stromal c-kit expression at 1 % cutoff correlated with increasing tumour grade, larger tumour size, hypercellularity, nuclear atypia, stromal overgrowth, infiltrative margins and mitotic count. These associations, however, were lost with higher (5 or 10 %) cutoffs. Conversely, decreased c-kit expression in the epithelial component correlated with increasing tumour grade, regardless of the cutoffs used. Stromal ALDH1A1 expression did not have significant associations with tumour grade or other adverse clinico-pathological features, regardless of different cutoffs. None of the cases showed significant epithelial ALDH1A1 expression. Expression of c-kit was associated with poorer overall survival (p = 0.011), while ALDH1A1 expression was associated with shorter recurrence-free survival (p = 0.036). In conclusion, c-kit expression was associated with higher tumour grade and adverse clinico-pathological features. However, these associations are cutoff dependent, partly explaining the variability in previously reported studies. ALDH1A1 expression did not have significant correlations with tumour grade and adverse clinico-pathological variables.

  10. FOBT Completion in FQHCs: Impact of Physician Recommendation, FOBT Information, or Receipt of the FOBT Kit

    PubMed Central

    Davis, Terry C.; Arnold, Connie L.; Rademaker, Alfred W.; Platt, Daci J.; Esparza, Julia; Liu, Dachao; Wolf, Michael S.

    2013-01-01

    Purpose To determine the effect of common components of primary care-based colorectal cancer (CRC) screening interventions on fecal occult blood test (FOBT) completion within rural and urban community clinics, including: (1) physician’s spoken recommendation, (2) providing information or education about FOBTs, and (3) physician providing the FOBT kit; to determine the relative effect of these interventions; and to compare the effect of each intervention between rural and urban clinics. Methods We conducted structured interviews with patients aged 50 years and over receiving care at community clinics that were noncompliant with CRC screening. Self-report of ever receiving a physician’s recommendation for screening, FOBT information or education, physician providing an FOBT kit, and FOBT completion were collected. Findings Participants included 849 screening-eligible adults; 77% were female and 68% were African American. The median age was 57; 33% lacked a high school diploma and 51% had low literacy. In multivariable analysis, all services were predictive of rural participants completing screening (physician recommendation: P = .002; FOBT education: P = .001; physician giving FOBT kit: P < .0001). In urban clinics, only physician giving the kit predicted FOBT completion (P < .0001). Compared to urban patients, rural patients showed a stronger relationship between FOBT completion and receiving a physician recommendation (risk ratio [RR]: 5.3 vs 2.1; P = .0001), receiving information or education on FOBTs (RR: 3.8 vs 1.9; P = .0002), or receiving an FOBT kit from their physician (RR: 22.3 vs 10.1; P = .035). Conclusions Participants who receive an FOBT kit from their physician are more likely to complete screening. PMID:22757955

  11. FOBT completion in FQHCs: impact of physician recommendation, FOBT information, or receipt of the FOBT kit.

    PubMed

    Davis, Terry C; Arnold, Connie L; Rademaker, Alfred W; Platt, Daci J; Esparza, Julia; Liu, Dachao; Wolf, Michael S

    2012-01-01

    To determine the effect of common components of primary care-based colorectal cancer (CRC) screening interventions on fecal occult blood test (FOBT) completion within rural and urban community clinics, including: (1) physician's spoken recommendation, (2) providing information or education about FOBTs, and (3) physician providing the FOBT kit; to determine the relative effect of these interventions; and to compare the effect of each intervention between rural and urban clinics. We conducted structured interviews with patients aged 50 years and over receiving care at community clinics that were noncompliant with CRC screening. Self-report of ever receiving a physician's recommendation for screening, FOBT information or education, physician providing an FOBT kit, and FOBT completion were collected. Participants included 849 screening-eligible adults; 77% were female and 68% were African American. The median age was 57; 33% lacked a high school diploma and 51% had low literacy. In multivariable analysis, all services were predictive of rural participants completing screening (physician recommendation: P = .002; FOBT education: P = .001; physician giving FOBT kit: P < .0001). In urban clinics, only physician giving the kit predicted FOBT completion (P < .0001). Compared to urban patients, rural patients showed a stronger relationship between FOBT completion and receiving a physician recommendation (risk ratio [RR]: 5.3 vs. 2.1; P = .0001), receiving information or education on FOBTs (RR: 3.8 vs 1.9; P = .0002), or receiving an FOBT kit from their physician (RR: 22.3 vs. 10.1; P = .035). Participants who receive an FOBT kit from their physician are more likely to complete screening. © 2012 National Rural Health Association.

  12. Deserts: Information and Hands-On Activities. Interactive Geography Kit.

    ERIC Educational Resources Information Center

    Bernard, Robin

    This book is designed to introduce students to a variety of fascinating desert ecosystems through a series of learning activities including games, graphs, experiments, and crafts. Each section contains an information section along with student activities and worksheets. The section topics are sand, scorpions, and snow; scenic sculpture; desert…

  13. Deserts: Information and Hands-On Activities. Interactive Geography Kit.

    ERIC Educational Resources Information Center

    Bernard, Robin

    This book is designed to introduce students to a variety of fascinating desert ecosystems through a series of learning activities including games, graphs, experiments, and crafts. Each section contains an information section along with student activities and worksheets. The section topics are sand, scorpions, and snow; scenic sculpture; desert…

  14. Gastric GISTs: Analysis of c-Kit, PDGFRA and BRAF mutations in relation to prognosis and clinical pathological characteristics of patients - A GIRCG study.

    PubMed

    Capelli, L; Petracci, E; Quagliuolo, V; Saragoni, L; Colombo, P; Morgagni, P; Calistri, D; Tomezzoli, A; Di Cosmo, M; Roviello, F; Vindigni, C; Coniglio, A; Villanacci, V; Catarci, M; Coppola, L; Alfieri, S; Ricci, R; Capella, C; Rausei, S; Gulino, D; Amadori, D; Ulivi, P

    2016-08-01

    Gastric gastrointestinal stromal tumors (GISTs) represent a subgroup of GISTs with a better prognosis than those located in other areas. In this retrospective study we performed a molecular characterization of a large series of patients with gastric GISTs in relation to clinical-pathological characteristics and prognosis. DNA was extracted from paraffin-embedded sections from 221 gastric GIST patients submitted to surgery. Exons 9, 11, 13 and 17 of KIT, exons 12 and 18 of PDGFRA and exons 11 and 15 of BRAF were analyzed by direct sequencing. Cox regression analysis adjusted for clinical-pathological factors was performed to evaluate KIT and PDGFRA mutations in relation to the composite endpoint of relapse or death. KIT and PDGFRA mutations were observed in 119 (53.8%) and 56 (25.3%) patients, respectively, whereas 46 (20.8%) patients had wild type (wt) disease. Univariable analyses showed that a high Miettinen risk category and the presence of ulceration and KIT deletions were associated with increased risk of relapse or death (p < 0.001; p = 0.0389 and p = 0.002, respectively). After adjusting for Miettinen risk score, KIT deletions remained an independent prognostic factor (HRadj = 2.65, 95% CI [1.15-6.13], p = 0.023). Moreover, KIT deletions in exon 11 codons 557, 558 or 559 were associated with a higher risk of relapse or death than wt tumors (HRadj = 3.29 95% CI [1.64-6.64], p = 0.001). KIT deletions in exon 11, especially those involving codons 557, 558 or 559, were correlated with a more aggressive gastric GIST phenotype and increased risk of relapse or death. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. E-KIT: An Electronic-Knowledge Information Tool for Organizing Site Information and Improving Technical Communication with Stakeholders - 13082

    SciTech Connect

    Kautsky, Mark; Findlay, Richard C.; Hodges, Rex A.

    2013-07-01

    Managing technical references for projects that have long histories is hampered by the large collection of documents, each of which might contain discrete pieces of information relevant to the site conceptual model. A database application has been designed to improve the efficiency of retrieving technical information for a project. Although many databases are currently used for accessing analytical and geo-referenced data, applications designed specifically to manage technical reference material for projects are scarce. Retrieving site data from the array of available references becomes an increasingly inefficient use of labor. The electronic-Knowledge Information Tool (e-KIT) is designed as a project-level resource to access and communicate technical information. The e-KIT is a living tool that grows as new information becomes available, and its value to the project increases as the volume of site information increases. Having all references assembled in one location with complete reference citations and links to elements of the site conceptual model offers a way to enhance communication with outside groups. The published and unpublished references are incorporated into the e-KIT, while the compendium of references serves as a complete bibliography for the project. (authors)

  16. [Physiology and pathology of visual information processing].

    PubMed

    Kitahara, Kenji

    2007-03-01

    clinically diagnosed 88 male dichromats(31 protanopes, 56 deuteranopes, and one unclassified subject). This subject had a new form of X-linked pigment gene with a unique arrangement of exon 5(Y277 from the long-wavelength-sensitive gene and A 285 from the middle-wavelength-sensitive gene). Mutational analysis of patients with achromatopsia disclosed CNGA3 mutations (p.R 436 W, p.L633 P) in one of 14 patients, suggesting low frequency (7%, 1/14) of CNGA3 mutations in the Japanese population. Three novel NR2E3 mutations (p.R 104 Q, p.R 334 G, p.Q 350 X) were identified in both mild and severe forms of ESCS. A novel homozygous GRK1 mutation (p.P 391 H) was found in the Oguchi disease patient with reduced cone responses. This is the first reported Japanese patient with GRK1 -associated Oguchi disease. 3. Information processing of the visual cortex and vision Regarding information processing in the visual cortex, we developed the stimulus to improve identifying retinotopy of the human visual cortex. We performed two types of fMRI experiments. One provided a quick method of mapping retinotopy using a composite stimulus with both ring- and wedge-shaped stimuli. The other provided a method which can show the horizontal meridian clearer. We explored the activation of the visual cortex associated with color perception. In our studies of the color center, we first researched the symptoms and lesions of cerebral achromatopsia, and we next performed the fMRI experiments with a pseudoisochromatic plate test and with a color arrangement test. After this we also performed the fMRI experiments with a complex color painting. We realized objective perimetry with functional brain images. We first developed the software to depict a visual field from the signals of MR imaging. Next we performed the experiment with hemifield stimulation and showed the possibility of its clinical application. Then we showed its reproducibility, performing the experiment with more complicated letter-shaped masked

  17. Standards to support information systems integration in anatomic pathology.

    PubMed

    Daniel, Christel; García Rojo, Marcial; Bourquard, Karima; Henin, Dominique; Schrader, Thomas; Della Mea, Vincenzo; Gilbertson, John; Beckwith, Bruce A

    2009-11-01

    Integrating anatomic pathology information- text and images-into electronic health care records is a key challenge for enhancing clinical information exchange between anatomic pathologists and clinicians. The aim of the Integrating the Healthcare Enterprise (IHE) international initiative is precisely to ensure interoperability of clinical information systems by using existing widespread industry standards such as Digital Imaging and Communication in Medicine (DICOM) and Health Level Seven (HL7). To define standard-based informatics transactions to integrate anatomic pathology information to the Healthcare Enterprise. We used the methodology of the IHE initiative. Working groups from IHE, HL7, and DICOM, with special interest in anatomic pathology, defined consensual technical solutions to provide end-users with improved access to consistent information across multiple information systems. The IHE anatomic pathology technical framework describes a first integration profile, "Anatomic Pathology Workflow," dedicated to the diagnostic process including basic image acquisition and reporting solutions. This integration profile relies on 10 transactions based on HL7 or DICOM standards. A common specimen model was defined to consistently identify and describe specimens in both HL7 and DICOM transactions. The IHE anatomic pathology working group has defined standard-based informatics transactions to support the basic diagnostic workflow in anatomic pathology laboratories. In further stages, the technical framework will be completed to manage whole-slide images and semantically rich structured reports in the diagnostic workflow and to integrate systems used for patient care and those used for research activities (such as tissue bank databases or tissue microarrayers).

  18. University of California, Irvine-Pathology Extraction Pipeline: the pathology extraction pipeline for information extraction from pathology reports.

    PubMed

    Ashish, Naveen; Dahm, Lisa; Boicey, Charles

    2014-12-01

    We describe Pathology Extraction Pipeline (PEP)--a new Open Health Natural Language Processing pipeline that we have developed for information extraction from pathology reports, with the goal of populating the extracted data into a research data warehouse. Specifically, we have built upon Medical Knowledge Analysis Tool pipeline (MedKATp), which is an extraction framework focused on pathology reports. Our particular contributions include additional customization and development on MedKATp to extract data elements and relationships from cancer pathology reports in richer detail than at present, an abstraction layer that provides significantly easier configuration of MedKATp for extraction tasks, and a machine-learning-based approach that makes the extraction more resilient to deviations from the common reporting format in a pathology reports corpus. We present experimental results demonstrating the effectiveness of our pipeline for information extraction in a real-world task, demonstrating performance improvement due to our approach for increasing extractor resilience to format deviation, and finally demonstrating the scalability of the pipeline across pathology reports for different cancer types.

  19. A biotic video game smart phone kit for formal and informal biophysics education

    NASA Astrophysics Data System (ADS)

    Kim, Honesty; Lee, Seung Ah; Riedel-Kruse, Ingmar

    2015-03-01

    Novel ways for formal and informal biophysics education are important. We present a low-cost biotic game design kit that incorporates microbial organisms into an interactive gaming experience: A 3D-printable microscope containing four LEDs controlled by a joystick enable human players to provide directional light stimuli to the motile single-celled organism Euglena gracilis. These cellular behaviors are displayed on the integrated smart phone. Real time cell-tracking couples these cells into interactive biotic video game play, i.e., the human player steers Euglena to play soccer with virtual balls and goals. The player's learning curve in mastering this fun game is intrinsically coupled to develop a deeper knowledge about Euglena's cell morphology and the biophysics of its phototactic behavior. This kit is dual educational - via construction and via play - and it provides an engaging theme for a formal biophysics devices class as well as to be presented in informal outreach activities; its low cost and open soft- and hardware should enable wide adoption.

  20. [The changes of hemodynamic parameters, pathology and c-kit mRNA expression in myocardium after acute myocardial infarction in rats].

    PubMed

    Chen, Shiqian; Long, Weifu; Wu, Wenchao; Jiang, Congxun; Liu, Xiaojing; Li, Liang

    2009-06-01

    This study was aimed to investigate the changes of hemodynamic parameters, pathology and c kit mRNA expression in myocardium after acute myocardial infarctionin (AMI) in rats, and to elucidate the relationship between these three kinds of changes. Sixty six adult male SD rats were randomly divided into normal group, Sham groups and ligation groups. The rat model of AMI was set up by ligating the left anterior descending artery. Hemodynamic parameters, pathological changes and c kit mRNA expression in myocardiam were examined. The results revealed that there were no statistically significant differences in hemodynamic parameters between normal group and Sham groups. Compared with the normal group, all ligation groups exhibited significantly decreased left ventricular systolic pressure (LVSP) and +/-dp/dtmax (P<0.01), and increased left ventricular end diastolic pressure (LVEDP, P<0.01). In the other ligation groups, compared with 6th hour group after ligation, there appeared striking increase of LVSP, LVEDP and +/-dp/dtmax (P<0.05). HE staining in myocardiam showed that there are necrosis and derangement at 24th hour group after ligation ,and a great number of inflammatory cells infiltration around the infarct zone at 3rd day group after ligation, and granulation tissue infiltrated into the infarct zone at 14th day group after ligation. In all five time points groups after ligation, the levels of c-kit mRNA expression were 0.99 fold, 1.06 fold, 1.46 fold, 1.91 fold and 2.67 fold, respectively, compared with Sham groups. The results suggest that cardiac stem cells in myocardium might contribute to the role of regenerating myocardium via self proliferation after acute myocardial infarction, but further investigation is still needed.

  1. Survival Kit - Food Kit

    NASA Image and Video Library

    1962-10-01

    S62-08742 (1962) --- Food kit used by Mercury astronauts. Some is dehydrated and needs water, other packets are ready to eat. Size is measured relative to a ruler. Included are packets of mushroom soup, orange-grapefruit juice, cocoa beverage, pineapple juice, chicken with gravy, pears, strawberries, beef and vegetables and other assorted food containers. Photo credit: NASA

  2. Survival Kit - Food Kit

    NASA Image and Video Library

    1962-10-01

    S62-08743 (1962) --- Food kit used by Mercury astronauts. Some is dehydrated and needs water, other packets are ready to eat. Size is measured relative to a ruler. Included are packets of mushroom soup, orange-grapefruit juice, cocoa beverage, pineapple juice, chicken with gravy, pears, strawberries, beef and vegetables and other assorted food containers. Photo credit: NASA

  3. Tool kit development to refine and visualize essential climate data and information for marine protected areas

    NASA Astrophysics Data System (ADS)

    Cecil, L.; Stachniewicz, J.; Shein, K. A.; Ansari, S.; Jarvis, C.

    2013-05-01

    larger gridded data products, such as NOAA's satellite Climate Data Records to the geographic boundaries of each included marine protected area (MPA). These clipped data sets are processed to produce MPA-specific analytics (e.g., files for averages, extremes, peaks over threshold, etc). Once a specific MPA has been selected, the associated data may be visualized, analyzed, and exported to other formats (e.g., netCDF, KML) from within the tool. The WCT-IMPACT tool kit will provide marine ecosystem managers with the capacity to answer such questions as what was the climate like during periods of optimal ecological health, or have climate conditions changed equally across an ecosystem's domain? The WCT-IMPACT extension is being developed specifically to address the needs of marine ecosystem managers to have access to relevant climate data and information for developing ecosystem-scale climate assessments, while retaining the ability for a WCT user to identify and access the full suite of georeferenced climate data provided by NCDC. In this tool kit development scheme, the need to coordinate with the resource managers is paramount and end user participation in an iterative process with the climate scientists is essential.

  4. The caCORE Software Development Kit: Streamlining construction of interoperable biomedical information services

    PubMed Central

    Phillips, Joshua; Chilukuri, Ram; Fragoso, Gilberto; Warzel, Denise; Covitz, Peter A

    2006-01-01

    Background Robust, programmatically accessible biomedical information services that syntactically and semantically interoperate with other resources are challenging to construct. Such systems require the adoption of common information models, data representations and terminology standards as well as documented application programming interfaces (APIs). The National Cancer Institute (NCI) developed the cancer common ontologic representation environment (caCORE) to provide the infrastructure necessary to achieve interoperability across the systems it develops or sponsors. The caCORE Software Development Kit (SDK) was designed to provide developers both within and outside the NCI with the tools needed to construct such interoperable software systems. Results The caCORE SDK requires a Unified Modeling Language (UML) tool to begin the development workflow with the construction of a domain information model in the form of a UML Class Diagram. Models are annotated with concepts and definitions from a description logic terminology source using the Semantic Connector component. The annotated model is registered in the Cancer Data Standards Repository (caDSR) using the UML Loader component. System software is automatically generated using the Codegen component, which produces middleware that runs on an application server. The caCORE SDK was initially tested and validated using a seven-class UML model, and has been used to generate the caCORE production system, which includes models with dozens of classes. The deployed system supports access through object-oriented APIs with consistent syntax for retrieval of any type of data object across all classes in the original UML model. The caCORE SDK is currently being used by several development teams, including by participants in the cancer biomedical informatics grid (caBIG) program, to create compatible data services. caBIG compatibility standards are based upon caCORE resources, and thus the caCORE SDK has emerged as a key

  5. The caCORE Software Development Kit: streamlining construction of interoperable biomedical information services.

    PubMed

    Phillips, Joshua; Chilukuri, Ram; Fragoso, Gilberto; Warzel, Denise; Covitz, Peter A

    2006-01-06

    Robust, programmatically accessible biomedical information services that syntactically and semantically interoperate with other resources are challenging to construct. Such systems require the adoption of common information models, data representations and terminology standards as well as documented application programming interfaces (APIs). The National Cancer Institute (NCI) developed the cancer common ontologic representation environment (caCORE) to provide the infrastructure necessary to achieve interoperability across the systems it develops or sponsors. The caCORE Software Development Kit (SDK) was designed to provide developers both within and outside the NCI with the tools needed to construct such interoperable software systems. The caCORE SDK requires a Unified Modeling Language (UML) tool to begin the development workflow with the construction of a domain information model in the form of a UML Class Diagram. Models are annotated with concepts and definitions from a description logic terminology source using the Semantic Connector component. The annotated model is registered in the Cancer Data Standards Repository (caDSR) using the UML Loader component. System software is automatically generated using the Codegen component, which produces middleware that runs on an application server. The caCORE SDK was initially tested and validated using a seven-class UML model, and has been used to generate the caCORE production system, which includes models with dozens of classes. The deployed system supports access through object-oriented APIs with consistent syntax for retrieval of any type of data object across all classes in the original UML model. The caCORE SDK is currently being used by several development teams, including by participants in the cancer biomedical informatics grid (caBIG) program, to create compatible data services. caBIG compatibility standards are based upon caCORE resources, and thus the caCORE SDK has emerged as a key enabling technology for

  6. Network Kits.

    ERIC Educational Resources Information Center

    Falk, Howard

    1999-01-01

    Describes interconnection methods, speed, and comparative equipment costs of networking starter kits. These kits supply network-connection devices that plug into or connect to each computer that is part of a network; they may also provide interconnection cables and installation software needed to set up a network. Reviews 20 kits that use a…

  7. Pathology

    SciTech Connect

    Rubin, E.; Farber, J.L. )

    1988-01-01

    This book contains 29 chapters. Some of the titles are: Genetic and Systemic Diseases; Cell Injury; Inflammation; The Gastrointestinal o Tract; The Pancreas; Environmental and Nutritional Pathology; Infectious and Parasitic Diseases; and Blood Vessels.

  8. Quality of web-based information on pathological gambling.

    PubMed

    Khazaal, Yasser; Chatton, Anne; Cochand, Sophie; Jermann, Françoise; Osiek, Christian; Bondolfi, Guido; Zullino, Daniele

    2008-09-01

    The present study aims to evaluate the quality of web-based information on gambling and to investigate potential content quality indicators. The following key words: gambling, pathological gambling, excessive gambling, gambling problem and gambling addiction were entered into two popular search engines: Google and Yahoo. Websites were assessed with a standardized proforma designed to rate sites on the basis of "accountability", "presentation", "interactivity", "readability" and "content quality". "Health on the Net" (HON) quality label, and DISCERN scale scores aiding people without content expertise to assess quality of written health publication were used to verify their efficiency as quality indicators. Of the 200 links identified, 75 websites were included. The results of the study indicate low scores on each of the measures. A composite global score appeared as a good content quality indicator. While gambling-related education websites for patients are common, their global quality is poor. There is a need for useful evidence-based information about gambling on the web. As the phenomenon has greatly increased, it could be relevant for Internet sites to improve their content by using global score as a quality indicator.

  9. [Pathology websites in the World Wide Web. A guide for a specific research of pathology information on the Internet].

    PubMed

    Böhm, J

    2008-05-01

    Being a global information network, the internet has becoming increasingly important for pathologists as a medium for professional communication and information. Although a large number of pathology-specific websites (PSWs) are accessible on the internet, the potentials of PSWs are still barely known. Since there is no global catalog for all the pathology websites, certain PSWs are difficult to find on the internet. PSWs offer lavishly illustrated education material for undergraduates and postgraduates in pathology, but may also be very useful as reference books or as an instrument of continuing medical education (CME) for experienced pathologists. The spectrum of PSW media comprises electronic training manuals, journals, case collections, photo-archives, and even complete section series of virtual microscopy. PSWs are available at any time, can be updated permanently and linked to further online sources of information. We demonstrate how to find PSWs and present an annotated list of some 100 of the best PSWs.

  10. Improving the quality of information on pathology request forms.

    PubMed

    Burnett, Leslie; Chesher, Douglas; Mudaliar, Yugan

    2004-01-01

    We have investigated the causes of incomplete pathology request forms received at our clinical chemistry laboratory. Based on a request form audit we found that the data most frequently missing from a pathology request form was the doctor's name, unique identification provider number, or signature. We examined the effect of issuing the requesting doctors with self-inking stamps personalized with their name and a unique provider number. The intervention led to an immediate and sustained improvement in compliance, with the proportion of incomplete forms falling from 43% to 2%. In contrast, distribution of a memorandum alone made no significant change to the number of pathology request forms with incomplete data arriving at the laboratory. This study describes a simple and low-cost solution to one of the causes of incomplete pathology request forms. It also demonstrates the effectiveness of systems improvement in health care.

  11. The Indonesia Kit. A Study Kit.

    ERIC Educational Resources Information Center

    Briere, Elaine; Gage, Susan

    This document is designed for Canadians interested in the South Pacific island chain nation of Indonesia. The kit includes information, photographs, and illustrations concerning Indonesia, West Papua (Irian Jaya), and East Timor. There are discussions of Indonesia's environment, its transmigration program, development refugees, and ties with…

  12. Building Your Program. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)

    ERIC Educational Resources Information Center

    Unger, Karen V.

    2011-01-01

    "Building Your Program" is intended to help mental health authorities, agency administrators, and program leaders think through and develop Supported Education. The first part of this booklet gives you background information about the Supported Education model. Specific information about your role in implementing and sustaining Supported Education…

  13. Leisure Counseling. A Kit.

    ERIC Educational Resources Information Center

    Epperson, Arlin; And Others

    This set of materials intended for use in the development of programs in leisure services and a vocational counseling contains information about a Leisure Counseling Media Kit, with directions for ordering a slide-tape program. Order forms and additional information about leisure counseling supplies are also included. A brief pamphlet describes…

  14. Early Childhood Kits.

    ERIC Educational Resources Information Center

    National Center on Educational Media and Materials for the Handicapped, Columbus, OH.

    Selected from the National Instructional Materials Information System (NIMIS)--a computer based on-line interactive retrieval system on special education materials, the bibliography covers 80 kits for developing skills at the early childhood level. Entries are presented in order of NIMIS accession number and include the following information:…

  15. Keep in touch (KIT): perspectives on introducing internet-based communication and information technologies in palliative care.

    PubMed

    Guo, Qiaohong; Cann, Beverley; McClement, Susan; Thompson, Genevieve; Chochinov, Harvey Max

    2016-08-02

    Hospitalized palliative patients need to keep in touch with their loved ones. Regular social contact may be especially difficult for individuals on palliative care in-patient units due to the isolating nature of hospital settings. Technology can help mitigate isolation by facilitating social connection. This study aimed to explore the acceptability of introducing internet-based communication and information technologies for patients on a palliative care in-patient unit. In the first phase of the Keep in Touch (KIT) project, a diverse group of key informants were consulted regarding their perspectives on web-based communication on in-patient palliative care units. Participants included palliative patients, family members, direct care providers, communication and information technology experts, and institutional administrators. Data was collected through focus groups, interviews and drop-in consultations, and was analyzed for themes, consensus, and major differences across participant groups. Hospitalized palliative patients and their family members described the challenges of keeping in touch with family and friends. Participants identified numerous examples of ways that communication and information technologies could benefit patients' quality of life and care. Patients and family members saw few drawbacks associated with the use of such technology. While generally supportive, direct care providers were concerned that patient requests for assistance in using the technology would place increased demands on their time. Administrators and IT experts recognized issues such as privacy and costs related to offering these technologies throughout an organization and in the larger health care system. This study affirmed the acceptability of offering internet-based communication and information technologies on palliative care in-patient units. It provides the foundation for trialing these technologies on a palliative in-patient unit. Further study is needed to confirm the

  16. FOBT Completion in FQHCs: Impact of Physician Recommendation, FOBT Information, or Receipt of the FOBT Kit

    ERIC Educational Resources Information Center

    Davis, Terry C.; Arnold, Connie L.; Rademaker, Alfred W.; Platt, Daci J.; Esparza, Julia; Liu, Dachao; Wolf, Michael S.

    2012-01-01

    Purpose: To determine the effect of common components of primary care-based colorectal cancer (CRC) screening interventions on fecal occult blood test (FOBT) completion "within" rural and urban community clinics, including: (1) physician's spoken recommendation, (2) providing information or education about FOBTs, and (3) physician providing the…

  17. Training Frontline Staff. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)

    ERIC Educational Resources Information Center

    Unger, Karen V.

    2011-01-01

    This four-part workbook will help program leaders teach education specialists the principles, processes, and skills necessary to deliver effective Supported Education services. The workbook includes the following: (1) Basic elements and practice principles of Supported Education; (2) Knowledge and skills to help consumers make informed choices…

  18. FOBT Completion in FQHCs: Impact of Physician Recommendation, FOBT Information, or Receipt of the FOBT Kit

    ERIC Educational Resources Information Center

    Davis, Terry C.; Arnold, Connie L.; Rademaker, Alfred W.; Platt, Daci J.; Esparza, Julia; Liu, Dachao; Wolf, Michael S.

    2012-01-01

    Purpose: To determine the effect of common components of primary care-based colorectal cancer (CRC) screening interventions on fecal occult blood test (FOBT) completion "within" rural and urban community clinics, including: (1) physician's spoken recommendation, (2) providing information or education about FOBTs, and (3) physician providing the…

  19. Identifying Personality Pathology Associated With Major Depressive Episodes: Incremental Validity of Informant Reports

    PubMed Central

    Galione, Janine N.; Oltmanns, Thomas F.

    2016-01-01

    Major limitations are associated with the use of a single source of information to assess personality pathology. The construct validity of standardized interviews and informant reports on personality pathology has been established relative to other measures of personality pathology, but it is also important to consider these measures in relation to other constructs that should be related to personality pathology. One example is major depression. In this study, we evaluated whether less common clinical methods of assessment for measuring the same personality pathology constructs, including semistructured interviews and informant reports, demonstrate unique validity, using major depressive episode (MDE) as the external criterion. This analysis focuses on a representative, community-based sample of 1,437 participants and informants. We conducted a hierarchical logistic regression analysis and determined the order of entering the predictor variables based on likelihood of being used in a clinical setting as well as empirical recommendations. Each step of our regression model significantly increased our ability to predict lifetime MDE, including self, interviewer, and informant reports of personality pathology. Overall, these findings indicate that multiple sources of personality assessment provide unique information about the relationship between maladaptive personality traits and a history of MDE. Thus, semistructured diagnostic interviews and informant reports can be used as a resource to improve the validity of personality assessments. PMID:24004355

  20. User Authentication. SPEC Kit.

    ERIC Educational Resources Information Center

    Plum, Terry, Comp.; Bleiler, Richard, Comp.

    2001-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to examine the systems research libraries use to authenticate and authorize the users of their online networked information resources. A total of 52 of 121 ARL member libraries responded to…

  1. User Authentication. SPEC Kit.

    ERIC Educational Resources Information Center

    Plum, Terry, Comp.; Bleiler, Richard, Comp.

    2001-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to examine the systems research libraries use to authenticate and authorize the users of their online networked information resources. A total of 52 of 121 ARL member libraries responded to…

  2. Ohio EPA Teachers Kit.

    ERIC Educational Resources Information Center

    Ohio State Environmental Protection Agency, Columbus.

    In an effort to provide teachers in Ohio with assistance in environmental education, the Ohio Environmental Protection Agency (EPA) has produced this teachers kit. It is designed to describe what the Ohio EPA is doing to protect Ohio's air, land, and water. The background information provides an historical account of some of the events that have…

  3. Balloons and Science Kit.

    ERIC Educational Resources Information Center

    Balloon Council, Washington, DC.

    This document provides background information on balloons including: (1) the history of balloons; (2) balloon manufacturing; (3) biodegradability; (4) the fate of latex balloons; and (5) the effect of balloons on the rainforest and sea mammals. Also included as part of this instructional kit are four fun experiments that allow students to…

  4. [Conference Time Kit.

    ERIC Educational Resources Information Center

    National School Public Relations Association, Washington, DC.

    This multimedia kit, for use with and by teachers from kindergarten through the upper elementary grades, consists of four components: 1) a filmstrip for teachers; 2) the 1970 edition of a handbook, "Conference Time for Teachers and Parents"; 3) a filmstrip for parents; 4) a supporting parent information leaflet "How To Confer Successfully with…

  5. Vietnamese Culture Kit.

    ERIC Educational Resources Information Center

    Nguyen, Liem Thanh

    This booklet provides a brief description of the cultural background of the Vietnamese, the geography of the country of Vietnam, the history of the Vietnamese people, their language, beliefs, systems of values, religions, customs, feasts, and holidays. The kit is designed to provide American sponsors and teachers with meaningful information about…

  6. Ohio EPA Teachers Kit.

    ERIC Educational Resources Information Center

    Ohio State Environmental Protection Agency, Columbus.

    In an effort to provide teachers in Ohio with assistance in environmental education, the Ohio Environmental Protection Agency (EPA) has produced this teachers kit. It is designed to describe what the Ohio EPA is doing to protect Ohio's air, land, and water. The background information provides an historical account of some of the events that have…

  7. Build an Emergency Preparedness Kit

    MedlinePlus

    ... tire traction -Red or brightly- colored cloth -NOAA weather radio For more information on building emergency kits, ... and a flashlight with extra batteries. A NOAA weather radio warns the public of severe weather and ...

  8. Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts

    PubMed Central

    2011-01-01

    Background The present study assessed malaria RDT kits for adequate and correct packaging, design and labelling of boxes and components. Information inserts were studied for readability and accuracy of information. Methods Criteria for packaging, design, labelling and information were compiled from Directive 98/79 of the European Community (EC), relevant World Health Organization (WHO) documents and studies on end-users' performance of RDTs. Typography and readability level (Flesch-Kincaid grade level) were assessed. Results Forty-two RDT kits from 22 manufacturers were assessed, 35 of which had evidence of good manufacturing practice according to available information (i.e. CE-label affixed or inclusion in the WHO list of ISO13485:2003 certified manufacturers). Shortcomings in devices were (i) insufficient place for writing sample identification (n = 40) and (ii) ambiguous labelling of the reading window (n = 6). Buffer vial labels were lacking essential information (n = 24) or were of poor quality (n = 16). Information inserts had elevated readability levels (median Flesch Kincaid grade 8.9, range 7.1 - 12.9) and user-unfriendly typography (median font size 8, range 5 - 10). Inadequacies included (i) no referral to biosafety (n = 18), (ii) critical differences between depicted and real devices (n = 8), (iii) figures with unrealistic colours (n = 4), (iv) incomplete information about RDT line interpretations (n = 31) and no data on test characteristics (n = 8). Other problems included (i) kit names that referred to Plasmodium vivax although targeting a pan-species Plasmodium antigen (n = 4), (ii) not stating the identity of the pan-species antigen (n = 2) and (iii) slight but numerous differences in names displayed on boxes, device packages and information inserts. Three CE labelled RDT kits produced outside the EC had no authorized representative affixed and the shape and relative dimensions of the CE symbol affixed did not comply with the Directive 98/79/EC

  9. Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts.

    PubMed

    Gillet, Philippe; Maltha, Jessica; Hermans, Veerle; Ravinetto, Raffaella; Bruggeman, Cathrien; Jacobs, Jan

    2011-02-13

    The present study assessed malaria RDT kits for adequate and correct packaging, design and labelling of boxes and components. Information inserts were studied for readability and accuracy of information. Criteria for packaging, design, labelling and information were compiled from Directive 98/79 of the European Community (EC), relevant World Health Organization (WHO) documents and studies on end-users' performance of RDTs. Typography and readability level (Flesch-Kincaid grade level) were assessed. Forty-two RDT kits from 22 manufacturers were assessed, 35 of which had evidence of good manufacturing practice according to available information (i.e. CE-label affixed or inclusion in the WHO list of ISO13485:2003 certified manufacturers). Shortcomings in devices were (i) insufficient place for writing sample identification (n=40) and (ii) ambiguous labelling of the reading window (n=6). Buffer vial labels were lacking essential information (n=24) or were of poor quality (n=16). Information inserts had elevated readability levels (median Flesch Kincaid grade 8.9, range 7.1-12.9) and user-unfriendly typography (median font size 8, range 5-10). Inadequacies included (i) no referral to biosafety (n=18), (ii) critical differences between depicted and real devices (n=8), (iii) figures with unrealistic colours (n=4), (iv) incomplete information about RDT line interpretations (n=31) and no data on test characteristics (n=8). Other problems included (i) kit names that referred to Plasmodium vivax although targeting a pan-species Plasmodium antigen (n=4), (ii) not stating the identity of the pan-species antigen (n=2) and (iii) slight but numerous differences in names displayed on boxes, device packages and information inserts. Three CE labelled RDT kits produced outside the EC had no authorized representative affixed and the shape and relative dimensions of the CE symbol affixed did not comply with the Directive 98/79/EC. Overall, RDTs with evidence of GMP scored better

  10. 21 CFR 864.2260 - Chromosome culture kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Chromosome culture kit. 864.2260 Section 864.2260...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260 Chromosome culture kit. (a) Identification. A chromosome culture kit is a device containing the necessary...

  11. 21 CFR 864.2260 - Chromosome culture kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Chromosome culture kit. 864.2260 Section 864.2260...) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260 Chromosome culture kit. (a) Identification. A chromosome culture kit is a device containing the necessary...

  12. Improve synthetic retinal OCT images with present of pathologies and textural information

    NASA Astrophysics Data System (ADS)

    Shahrian Varnousfaderani, Ehsan; Vogl, Wolf-Dieter; Wu, Jing; Gerendas, Bianca S.; Simader, Christian; Langs, Georg; Waldstein, Sebastian M.; Schmidt-Erfurth, Ursula

    2016-03-01

    The lack of noise free Optical Coherence Tomography (OCT) images makes it challenging to quantitatively evaluate performance of image processing methods such as denoising methods. The synthetic noise free OCT images are needed to evaluate performance of image processing methods. The current synthetic methods fail to generate synthetic images that represent real OCT images with present of pathologies. They cannot correctly imitate real OCT data due to a tendency to smooth the data, losing texture information and even, pathologies such as cysts are simply smoothed away by these methods. The first aim of this paper is to use mathematical models to generate a synthetic noise free image that represent real retinal OCT B-scan or volume with present of clinically important pathologies. The proposed method partitions a B-scan obtained from real OCT into three regions (vitreous, retina and choroid) by segmenting the inner limiting membrane (ILM) and retinal pigment epithelium (RPE) surfaces as well as cysts regions by medical experts. Then retina region is further divided into small blocks. Different smoothness functions are used to estimate OCT signals in vitreous, choroid and cyst regions and in blocks of retina region. Estimating signals in block resolution enables our proposed method to capture more textural information by using a simple mathematical model (smoothness function) and using annotated cyst enables our method to model cyst pathology accurately. The qualitative evaluations show that proposed method generates more realistic B-scans with present of pathologies and textural information than other methods.

  13. Availability of Pre-Admission Information to Prospective Graduate Students in Speech-Language Pathology

    ERIC Educational Resources Information Center

    Tekieli Koay, Mary Ellen; Lass, Norman J.; Parrill, Madaline; Naeser, Danielle; Babin, Kelly; Bayer, Olivia; Cook, Megan; Elmore, Madeline; Frye, Rachel; Kerwood, Samantha

    2016-01-01

    An extensive Internet search was conducted to obtain pre-admission information and acceptance statistics from 260 graduate programmes in speech-language pathology accredited by the American Speech-Language-Hearing Association (ASHA) in the United States. ASHA is the national professional, scientific and credentialing association for members and…

  14. [Trends of utilization of information technologies in clinical laboratory and pathology domain].

    PubMed

    Tofukuji, Ikuo

    2007-08-01

    The life expectancy of the Japanese population is one of longest in the world. Society is aging, with fewer children, increasing the total national medical payment in Japan. This situation has forced the Government to reduce the payment and to increase the efficiency of the medical system, so information technologies are expected to contribute to these policies. Electronic patient record systems (EPR) were expected to be used widely, but only 23% of clinical training hospitals have implemented them. This is mainly due to the lack of incentives and large costs to install EPR. Standardization is a good method to reduce system construction cost and increase its quality. New global IHE activities are expected to solve these problems with methodologies of workflow analyses, standard applications, tests and demonstrations. Laboratory information systems (LIS) have a long history and tradition of standard interfaces for connecting computers with analyzers. IHE activities for LIS are providing easy and secure connections with hospital information systems (HIS). Pathology departments also have their own information systems. IHE activities for pathology were launched in 2005, and we are now developing in collaboration with the international IHE pathology working group, HL7 SIG pathology and DICOM WG-26. Pathologists and technical experts in Japanese laboratories are encouraged to join IHE activities to ensure good results.

  15. Availability of Pre-Admission Information to Prospective Graduate Students in Speech-Language Pathology

    ERIC Educational Resources Information Center

    Tekieli Koay, Mary Ellen; Lass, Norman J.; Parrill, Madaline; Naeser, Danielle; Babin, Kelly; Bayer, Olivia; Cook, Megan; Elmore, Madeline; Frye, Rachel; Kerwood, Samantha

    2016-01-01

    An extensive Internet search was conducted to obtain pre-admission information and acceptance statistics from 260 graduate programmes in speech-language pathology accredited by the American Speech-Language-Hearing Association (ASHA) in the United States. ASHA is the national professional, scientific and credentialing association for members and…

  16. Social Information Processing and Cluster B Personality Pathology among Clinic-Referred Adolescents.

    PubMed

    Hessels, Christel; van Aken, Marcel A G; Orobio de Castro, Bram; Laceulle, Odilia M; van Voorst, Guus

    2016-01-01

    This study investigated relations between personality pathology and mentalizing capacities reflected in social information processing (SIP) of adolescents. 96 adolescent outpatients completed a structured interview regarding SIP. Their clinicians completed a checklist based on DSM-IV, assessing severity of personality pathology. Significant relations were found between the severity of personality pathology and SIP: the more severe the personality pathology, the higher the intensity of reported emotions, the more likely adolescents were to choose inadequate coping strategies and aggressive reactions in social situations, and the more positively they evaluated aggressive reactions. Severity of traits of antisocial (ASPD) and borderline personality disorder (BPD) had unique associations with distinctive SIP variables: ASPD being more related to inadequate coping strategies, less reflection on other's motives and aggressive responses, and BPD being more related to avoidant or prosocial responses and in particular to memories of frustrating events. This study provides evidence for difficulties in SIP among adolescents with more severe personality pathology, suggesting that the steps in the SIP model can be used to operationalize mentalizing problems. The results seem to paint a picture of ASPD and BPD having a shared background, but their own specific problems concerning SIP. © 2016 S. Karger AG, Basel.

  17. Differentiating impulsive and premeditated aggression: self and informant perspectives among adolescents with personality pathology.

    PubMed

    Gauthier, Kris J; Furr, R Michael; Mathias, Charles W; Marsh-Richard, Dawn M; Dougherty, Donald M

    2009-02-01

    Previous research has articulated the conceptual differentiation of impulsive and premeditated aggression. Little, if any, of this research has examined personological differences among adolescents with aggression-oriented pathology, and little, if any, has examined both self and informant perspectives. The current study examined such differentiation within a Conduct Disorder population in which normal and pathological personality characteristics were examined via self- and informant-report. Results indicated the two forms of aggression were independent: high impulsive aggression was associated with high Neuroticism, but high premeditated aggression was associated with low Agreeableness and high Extraversion. Overall, adolescents high in impulsive aggression had a pattern of personality characteristics that are seen as socially-detached and emotionally volatile. In contrast, adolescents high in premeditated aggression had a pattern of characteristics seen as egocentric and socially-engaged but without concern for others. The results have implications for the social and motivational mechanisms producing the two forms of aggression.

  18. Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines.

    PubMed

    Scudamore, Cheryl L; Soilleux, Elizabeth J; Karp, Natasha A; Smith, Ken; Poulsom, Richard; Herrington, C Simon; Day, Michael J; Brayton, Cory F; Bolon, Brad; Whitelaw, Bruce; White, Eric S; Everitt, Jeffrey I; Arends, Mark J

    2016-01-01

    Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis, and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridization (ISH) datasets. This reporting framework will maximize the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  19. Kits in Motion

    ERIC Educational Resources Information Center

    Gee, Maureen

    1975-01-01

    Discusses three kits developed by museums in British Columbia for use in rural classrooms. The science kit on marine biology consists of modules which included specimens, books, audiovisual materials and student activities. (BR)

  20. Kits in Motion

    ERIC Educational Resources Information Center

    Gee, Maureen

    1975-01-01

    Discusses three kits developed by museums in British Columbia for use in rural classrooms. The science kit on marine biology consists of modules which included specimens, books, audiovisual materials and student activities. (BR)

  1. YourSELF. Middle School Nutrition Education Kit [Multimedia].

    ERIC Educational Resources Information Center

    Department of Agriculture, Washington, DC.

    This multimedia kit provides information and materials for teaching nutrition to middle school students (grades 7 and 8). The kit supports schools' efforts to make school meals healthier and more appealing to students. The materials provide information about the relationships between food, nutrition, growth, and health. The kit speaks directly to…

  2. GridKit

    SciTech Connect

    Peles, Slaven

    2016-11-06

    GridKit is a software development kit for interfacing power systems and power grid application software with high performance computing (HPC) libraries developed at National Labs and academia. It is also intended as interoperability layer between different numerical libraries. GridKit is not a standalone application, but comes with a suite of test examples illustrating possible usage.

  3. Levitation Kits Demonstrate Superconductivity.

    ERIC Educational Resources Information Center

    Worthy, Ward

    1987-01-01

    Describes the "Project 1-2-3" levitation kit used to demonstrate superconductivity. Summarizes the materials included in the kit. Discusses the effect demonstrated and gives details on how to obtain kits. Gives an overview of the documentation that is included. (CW)

  4. Levitation Kits Demonstrate Superconductivity.

    ERIC Educational Resources Information Center

    Worthy, Ward

    1987-01-01

    Describes the "Project 1-2-3" levitation kit used to demonstrate superconductivity. Summarizes the materials included in the kit. Discusses the effect demonstrated and gives details on how to obtain kits. Gives an overview of the documentation that is included. (CW)

  5. Kid's PACK: Population Awareness Campaign Kit.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This fun and educational kit is designed specifically for elementary students. The "Kid's PACK" (Population Awareness Campaign Kit) entertains and informs children on the environment and human population growth through stories, games, and concrete ideas for making a difference. In three booklets, the "Kid's PACK" offers…

  6. Instructional Support Services. SPEC Kit.

    ERIC Educational Resources Information Center

    Snyder, Carolyn A., Comp.; Logue, Susan, Comp.; Carter, Howard, Comp.; Soltys, Mickey, Comp.

    2001-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries. The survey was designed to gather information about the changes that have taken place in the last five years in the services libraries offer to support instruction on campus and in the library, as…

  7. Adult College Completion Tool Kit

    ERIC Educational Resources Information Center

    Tolbert, Michelle

    2012-01-01

    This "Adult College Completion Tool Kit" is designed to connect state administrators and local practitioners to the strategies, resources, and technical assistance tools resulting from the Department's work. States can use this information to identify and implement state adult education leadership priorities, supported by federal "Adult Education…

  8. Care Bears Environmental Awareness Kit.

    ERIC Educational Resources Information Center

    American Greetings Corp., Cleveland, OH.

    Studies show that the three most frequently cited sources of environmental information are family, school, and the media. This kit provides parents with an opportunity to increase a child's environmental awareness through activities which focus on the environment in a way children ages four to nine can understand. A workbook uses the popular Care…

  9. Self-Reported Personality Pathology Has Complex Structure and Imposing Simple Structure Degrades Test Information.

    PubMed

    Pettersson, Erik; Turkheimer, Eric

    2014-01-01

    Although simple structure is often used as a theoretical guideline for rotation of exploratory factor structures, its empirical foundation is sometimes not investigated. We examined the degree of simple structure in 2 self-report inventories advocated for the description of personality pathology. The multivariate complexity of the inventories was compared against simulated factorial solutions with increasing degrees of simple structure. Results revealed a high degree of complexity in both inventories, regardless of whether focusing on a few broad or many narrow factors and whether items or scales were analyzed. It is concluded that Thurstone's (1934) simple structure criteria are rarely fulfilled in multivariate personality pathology solutions, and, therefore, that alternate rotations represent equally justifiable ways to operationalize the space. Furthermore, using iterative test development to impose simple structure where none originally existed increased standard errors around the factor scores in the interstitial areas between imposed simple structure dimensions. In both simulated and real data, multidimensional item response theory test information functions based on complex solutions demonstrated that test information was uniformly distributed across the space. In contrast, in simple structure solutions, information was weak in areas of the space where nonconforming items had been removed. Implications are discussed.

  10. Transforming Libraries: Issues and Innovations in Preserving Digital Information. SPEC Kit 228 and SPEC Flyer 228. Issue Number 5.

    ERIC Educational Resources Information Center

    Soete, George J.

    The problem of preserving digital information and the strategies that are and might be employed to address it are the focus of this fifth issue of "Transforming Libraries." Twenty-one individuals involved at the technical or policy level in developing strategies for preserving digital information were interviewed. There is consensus on a…

  11. Distributive Education--Product Information Fact Sheet. Kit No. 69. Instructor's Manual [and] Student Learning Activity Guide.

    ERIC Educational Resources Information Center

    McLean, Robert

    An instructor's manual and student activity guide on the product information fact sheet are provided in this set of prevocational education materials which focuses on the vocational area of distributive education. (This set of materials is one of ninety-two prevocational education sets arranged around a cluster of seven vocational offerings:…

  12. Creation of learning kits

    NASA Technical Reports Server (NTRS)

    Stow, D. A.; Estes, J. E.; Mertz, F. C.

    1981-01-01

    A learning kit is an essential part of any remote sensing workshop, course, or in-house training program to provide the "hands-on" experience of working with remotely sensed imagery. This is the objective of laboratory and field exercises as well as the reason behind the production of imagery/map kits. The way in which these learning kits (containing conventional remotely sensed and collateral data products) are put together is described and some concerns that influence the creation of learning kits are discussed. These include budgetary constraints, number of imagery types, and number of collateral data types.

  13. Creation of learning kits

    NASA Technical Reports Server (NTRS)

    Stow, D. A.; Estes, J. E.; Mertz, F. C.

    1981-01-01

    A learning kit is an essential part of any remote sensing workshop, course, or in-house training program to provide the "hands-on" experience of working with remotely sensed imagery. This is the objective of laboratory and field exercises as well as the reason behind the production of imagery/map kits. The way in which these learning kits (containing conventional remotely sensed and collateral data products) are put together is described and some concerns that influence the creation of learning kits are discussed. These include budgetary constraints, number of imagery types, and number of collateral data types.

  14. Keep in Touch (KIT): feasibility of using internet-based communication and information technology in palliative care.

    PubMed

    Guo, Qiaohong; Cann, Beverley; McClement, Susan; Thompson, Genevieve; Chochinov, Harvey Max

    2017-05-06

    Confinement to an in-patient hospital ward impairs patients' sense of social support and connectedness. Providing the means, through communication technology, for patients to maintain contact with friends and family can potentially improve well-being at the end of life by minimizing social isolation and facilitating social connection. This study aimed to explore the feasibility of introducing internet-based communication and information technologies for in-patients and their families and to describe their experience in using this technology. A cross-sectional survey design was used to describe patient and family member experiences in using internet-based communication technology and health care provider views of using such technology in palliative care. Participants included 13 palliative in-patients, 38 family members, and 14 health care providers. An iPad or a laptop computer with password-protected internet access was loaned to each patient and family member for about two weeks or they used their own electronic devices for the duration of the patient's stay. Quantitative and qualitative data were collected from patients, families, and health care providers to discern how patients and families used the technology, its ease of use and its impact. Descriptive statistics and paired sample t-tests were used to analyze quantitative data; qualitative data were analyzed using constant comparative techniques. Palliative patients and family members used the technology to keep in touch with family and friends, entertain themselves, look up information, or accomplish tasks. Most participants found the technology easy to use and reported that it helped them feel better overall, connected to others and calm. The availability of competent, respectful, and caring technical support personnel was highly valued by patients and families. Health care providers identified that computer technology helped patients and families keep others informed about the patient's condition, enabled

  15. Community Consultation Kit.

    ERIC Educational Resources Information Center

    Boulder Area Growth Study Commission, CO.

    This kit, designed for leaders and participants, provides a model for organizing and taking part in Community Consultation Groups. The kit was designed to be used in connection with community concerns about growth in Boulder, Colorado. These groups build upon a previous survey to assist the Commission in determining specific growth concerns in the…

  16. Subthalamic deep brain stimulation reduces pathological information transmission to the thalamus in a rat model of parkinsonism.

    PubMed

    Anderson, Collin J; Sheppard, Daylan T; Huynh, Rachel; Anderson, Daria Nesterovich; Polar, Christian A; Dorval, Alan D

    2015-01-01

    The degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to parkinsonian motor symptoms via changes in electrophysiological activity throughout the basal ganglia. High-frequency deep brain stimulation (DBS) partially treats these symptoms, but the mechanisms are unclear. We hypothesize that motor symptoms of Parkinson's disease (PD) are associated with increased information transmission from basal ganglia output neurons to motor thalamus input neurons and that therapeutic DBS of the subthalamic nucleus (STN) treats these symptoms by reducing this extraneous information transmission. We tested these hypotheses in a unilateral, 6-hydroxydopamine-lesioned rodent model of hemiparkinsonism. Information transfer between basal ganglia output neurons and motor thalamus input neurons increased in both the orthodromic and antidromic directions with hemiparkinsonian (hPD) onset, and these changes were reversed by behaviorally therapeutic STN-DBS. Omnidirectional information increases in the parkinsonian state underscore the detrimental nature of that pathological information and suggest a loss of information channel independence. Therapeutic STN-DBS reduced that pathological information, suggesting an effective increase in the number of independent information channels. We interpret these data with a model in which pathological information and fewer information channels diminishes the scope of possible motor activities, driving parkinsonian symptoms. In this model, STN-DBS restores information-channel independence by eliminating or masking the parkinsonism-associated information, and thus enlarges the scope of possible motor activities, alleviating parkinsonian symptoms.

  17. Subthalamic deep brain stimulation reduces pathological information transmission to the thalamus in a rat model of parkinsonism

    PubMed Central

    Anderson, Collin J.; Sheppard, Daylan T.; Huynh, Rachel; Anderson, Daria Nesterovich; Polar, Christian A.; Dorval, Alan D.

    2015-01-01

    The degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to parkinsonian motor symptoms via changes in electrophysiological activity throughout the basal ganglia. High-frequency deep brain stimulation (DBS) partially treats these symptoms, but the mechanisms are unclear. We hypothesize that motor symptoms of Parkinson’s disease (PD) are associated with increased information transmission from basal ganglia output neurons to motor thalamus input neurons and that therapeutic DBS of the subthalamic nucleus (STN) treats these symptoms by reducing this extraneous information transmission. We tested these hypotheses in a unilateral, 6-hydroxydopamine-lesioned rodent model of hemiparkinsonism. Information transfer between basal ganglia output neurons and motor thalamus input neurons increased in both the orthodromic and antidromic directions with hemiparkinsonian (hPD) onset, and these changes were reversed by behaviorally therapeutic STN-DBS. Omnidirectional information increases in the parkinsonian state underscore the detrimental nature of that pathological information and suggest a loss of information channel independence. Therapeutic STN-DBS reduced that pathological information, suggesting an effective increase in the number of independent information channels. We interpret these data with a model in which pathological information and fewer information channels diminishes the scope of possible motor activities, driving parkinsonian symptoms. In this model, STN-DBS restores information-channel independence by eliminating or masking the parkinsonism-associated information, and thus enlarges the scope of possible motor activities, alleviating parkinsonian symptoms. PMID:26217192

  18. Burn Wise Awareness Kit

    EPA Pesticide Factsheets

    Health and safety outreach materials in the form of an awareness kit. Designed specifically for state, local, and tribal air agencies working to reduce wood smoke pollution, it includes best burn tips, social media m

  19. Machine learning classification of surgical pathology reports and chunk recognition for information extraction noise reduction.

    PubMed

    Napolitano, Giulio; Marshall, Adele; Hamilton, Peter; Gavin, Anna T

    2016-06-01

    Machine learning techniques for the text mining of cancer-related clinical documents have not been sufficiently explored. Here some techniques are presented for the pre-processing of free-text breast cancer pathology reports, with the aim of facilitating the extraction of information relevant to cancer staging. The first technique was implemented using the freely available software RapidMiner to classify the reports according to their general layout: 'semi-structured' and 'unstructured'. The second technique was developed using the open source language engineering framework GATE and aimed at the prediction of chunks of the report text containing information pertaining to the cancer morphology, the tumour size, its hormone receptor status and the number of positive nodes. The classifiers were trained and tested respectively on sets of 635 and 163 manually classified or annotated reports, from the Northern Ireland Cancer Registry. The best result of 99.4% accuracy - which included only one semi-structured report predicted as unstructured - was produced by the layout classifier with the k nearest algorithm, using the binary term occurrence word vector type with stopword filter and pruning. For chunk recognition, the best results were found using the PAUM algorithm with the same parameters for all cases, except for the prediction of chunks containing cancer morphology. For semi-structured reports the performance ranged from 0.97 to 0.94 and from 0.92 to 0.83 in precision and recall, while for unstructured reports performance ranged from 0.91 to 0.64 and from 0.68 to 0.41 in precision and recall. Poor results were found when the classifier was trained on semi-structured reports but tested on unstructured. These results show that it is possible and beneficial to predict the layout of reports and that the accuracy of prediction of which segments of a report may contain certain information is sensitive to the report layout and the type of information sought. Copyright

  20. Relationships: empirical contribution. Understanding personality pathology in adolescents: the five factor model of personality and social information processing.

    PubMed

    Hessels, Christel; van den Hanenberg, Danique; de Castro, Bram Orobio; van Aken, Marcel A G

    2014-02-01

    This study seeks to integrate two research traditions that lie at the base of the understanding of personality pathology in adolescents. The first research tradition refers to normal personality according to the Five Factor Model (FFM). The second tradition specifies the key feature of personality disorder as the capacity to mentalize, which can be reflected in Social Information Processing (SIP). In a clinical sample of 96 adolescents, the authors investigated response generation, coping strategy, and memories of past frustrating experiences as part of SIP, as mediator in the relationship between personality and personality pathology, and a possible moderating role of personality on the relationship between SIP and personality pathology. The hypothesized mediation, by which the effects of personality dimensions on personality pathology was expected to be mediated by SIP variables, was found only for the effect of Neuroticism, most specifically on BPD, which appeared to be mediated by memories the patients had about past frustrating conflict situations with peers. Some moderating effects of personality on the relationship between SIP variables and personality pathology were found, suggesting that high Agreeableness and sometimes low Neuroticism can buffer this relationship. These results suggest that personality dimensions and social cognitions both independently and together play a role in adolescents' personality pathology.

  1. Prediction of the Pathologic Gleason Score to Inform a Personalized Management Program for Prostate Cancer.

    PubMed

    Coley, R Yates; Zeger, Scott L; Mamawala, Mufaddal; Pienta, Kenneth J; Carter, H Ballentine

    2017-07-01

    Active surveillance (AS) is an alternative to curative intervention, but overtreatment persists. Imperfect alignment of prostate biopsy and Gleason score after radical prostatectomy (RP) may be a contributing factor. To develop a statistical model that predicts the post-RP Gleason score (pathologic Gleason score [PGS]) using clinical observations made in the course of AS. Repeated prostate-specific antigen measurements and biopsy Gleason scores from 964 very low-risk patients in the Johns Hopkins Active Surveillance cohort were used in the analysis. PGS observations from 191 patients who underwent RP were also included. A Bayesian joint model based on accumulated clinical data was used to predict PGS in these categories: 6 (grade group 1), 3+4 (grade group 2), 4+3 (grade group 3), and 8-10 (grade groups 4 and 5). The area under the receiver operating characteristic curve (AUC) and calibration of predictions was assessed in patients with post-RP Gleason score observations. The estimated probability of harboring a PGS >6 was <20% for most patients who had not experienced grade reclassification or elected surgery. Among patients with post-RP Gleason score observations, the AUC for predictions of PGS >6 was 0.74 (95% confidence interval, 0.66-0.81), and the mean absolute error was 0.022. Although the model requires external validation prior to adoption, PGS predictions can be used in AS to inform decisions regarding follow-up biopsies and remaining on AS. Predictions can be updated as additional data are observed. The joint modeling framework also accommodates novel biomarkers as they are identified and measured on AS patients. Measurements taken in the course of active surveillance can be used to accurately predict patients' underlying prostate cancer status. Predictions can be communicated to patients via a decision support tool and used to guide clinical decision making and reduce patient anxiety. Copyright © 2016 European Association of Urology. Published by

  2. Travel Medical Kit.

    PubMed

    Terry, Anne C; Haulman, N Jean

    2016-03-01

    "The traveler's medical kit is an essential tool for both the novice and expert traveler. It is designed to treat travel-related illness and injury and to ensure preexisting medical conditions are managed appropriately. Travelers are at increased risk for common gastrointestinal issues during travel. Respiratory illnesses make up approximately 8% of the ailments present in returned international travelers. Approximately 12% of travelers experience a travel-related skin condition. First aid treatment for minor injuries is essential to all travel medical kits. The complexity ranges from a small, simple case for the urban traveler to a larger, extensive case for wilderness travel."

  3. World Disarmament Kit.

    ERIC Educational Resources Information Center

    Woito, Robert, Ed.

    This kit presents a comprehensive introduction for students to arms control and disarmament issues. Included are copies of published and unpublished articles for each topic. Section I provides a self-survey to enable students to assess their own attitudes, values, and knowledge. The survey poses questions for which students select one of several…

  4. Personalized Thematic Kits

    ERIC Educational Resources Information Center

    Bontrager, Sharon

    2010-01-01

    Teaching Spanish at the K-5 level is a passion of mine, and the author would like to share some of the practical applications that she finds most rewarding and effective. She has found enthusiastic response to the creation of detailed language learning kits that are rooted in storytelling, but expanded to include home-made board games,…

  5. Theme Kits Made Easy.

    ERIC Educational Resources Information Center

    Eslinger, Leslie Silk

    Recognizing the long-lasting impact of young childrens learning through themes as well as the amount of teacher time spent in preparing for this type of teaching, this kit is designed to help teachers avoid the shortcomings of theme-based teaching, while capitalizing on the benefits of this approach. The book is presented in two sections. The…

  6. Theme Kits Made Easy.

    ERIC Educational Resources Information Center

    Eslinger, Leslie Silk

    Recognizing the long-lasting impact of young childrens learning through themes as well as the amount of teacher time spent in preparing for this type of teaching, this kit is designed to help teachers avoid the shortcomings of theme-based teaching, while capitalizing on the benefits of this approach. The book is presented in two sections. The…

  7. Projectable Basic Electronics Kit.

    ERIC Educational Resources Information Center

    H'ng, John; And Others

    1982-01-01

    Outlines advantages derived from constructing and using a Projectable Basic Electronics Kit and provides: (1) list of components; (2) diagrams of 10 finished components (resistor; capacitor; diode; switch; bulb; transistor; meter; variable capacitor; coil; connecting terminal); and (3) diode and transistor activities. (JN)

  8. Projectable Basic Electronics Kit.

    ERIC Educational Resources Information Center

    H'ng, John; And Others

    1982-01-01

    Outlines advantages derived from constructing and using a Projectable Basic Electronics Kit and provides: (1) list of components; (2) diagrams of 10 finished components (resistor; capacitor; diode; switch; bulb; transistor; meter; variable capacitor; coil; connecting terminal); and (3) diode and transistor activities. (JN)

  9. Core Competencies. SPEC Kit.

    ERIC Educational Resources Information Center

    McNeil, Beth, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to investigate the status of core competencies (i.e., the skills, knowledge, abilities, and attributes that employees across an organization are expected to have to contribute successfully…

  10. Voter Education Training Kit.

    ERIC Educational Resources Information Center

    Multi-District Inst. for Political Education, Pitman, NJ.

    Guides and resources in this kit are prepared for a six week to two month secondary voter education course. The objectives are to prepare and motivate eligible students to register and vote in the presidential election, to participate in the presidential election campaigning, and to increase their overall knowledge concerning the presidential…

  11. The ESL Starter Kit.

    ERIC Educational Resources Information Center

    Virginia Commonwealth Univ., Richmond. Virginia Adult Education and Literacy Resource Center.

    The kit is intended for teachers beginning to teach English as a Second Language (ESL). The first part offers some ideas for testing, registering, and placing students according to their needs and goals. A sample registration form, placement test, list of commercially-available tests, and sample needs assessments are included here. The second…

  12. Chat Reference. SPEC Kit.

    ERIC Educational Resources Information Center

    Ronan, Jana, Comp.; Turner, Carol, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to gather data on chat reference service. A total of 66 of 124 ARL member libraries responded to the survey. A copy of the questionnaire with tabulated results is presented. Representative…

  13. EPIE Educational Product Report: Early Learning Kits -- 25 Evaluations.

    ERIC Educational Resources Information Center

    EPIE Educational Product Report, 1975

    1975-01-01

    This report presents evaluations of 25 early learning materials kits, designed for use with young children in nursery school, kindergarten, and day care centers. Each evaluation includes: a physical description of the kit (with cost information), the target audience, content and objectives, methods of use, conditions of use, rationale, research…

  14. Organization Charts in ARL Libraries. SPEC Kit #170.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit is based on a review of the organization charts of 71 member libraries of the Association of Research Libraries (ARL) gathered in January 1991, compared with an earlier SPEC Kit published in 1986, and contains charts of 29 of the libraries. A summary of the chart analyses presents information about the titles of library directors,…

  15. EPIE Educational Product Report: Early Learning Kits -- 25 Evaluations.

    ERIC Educational Resources Information Center

    EPIE Educational Product Report, 1975

    1975-01-01

    This report presents evaluations of 25 early learning materials kits, designed for use with young children in nursery school, kindergarten, and day care centers. Each evaluation includes: a physical description of the kit (with cost information), the target audience, content and objectives, methods of use, conditions of use, rationale, research…

  16. The Allocation of Materials Funds. SPEC Kit 36.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Association of Research Libraries (ARL) kit contains source documents providing information on the general background, statistics/criteria, formulas, and decision-making processes used in the allocation of materials funds in academic libraries. The kit comprises: (1) a working paper on "Guidelines for the Allocation of Library Materials…

  17. Tickle Your Appetite: Team Nutrition's Education Kit for Child Care.

    ERIC Educational Resources Information Center

    Food and Consumer Service (USDA), Washington, DC.

    Adapted for child care and Head Start providers, this educator's kit contains activities and information to improve nutrition experiences for preschool-age children. In addition to the educator's guide, the kit includes a short videotape and audiotape with three segments that teach about trying different types of foods; about the taste, touch, and…

  18. Automatic transmission adapter kit

    SciTech Connect

    Stich, R.L.; Neal, W.D.

    1987-02-10

    This patent describes, in a four-wheel-drive vehicle apparatus having a power train including an automatic transmission and a transfer case, an automatic transmission adapter kit for installation of a replacement automatic transmission of shorter length than an original automatic transmission in the four-wheel-drive vehicle. The adapter kit comprises: an extension housing interposed between the replacement automatic transmission and the transfer case; an output shaft, having a first end which engages the replacement automatic transmission and a second end which engages the transfer case; first sealing means for sealing between the extension housing and the replacement automatic transmission; second sealing means for sealing between the extension housing and the transfer case; and fastening means for connecting the extension housing between the replacement automatic transmission and the transfer case.

  19. Staffing the Library Website. SPEC Kit.

    ERIC Educational Resources Information Center

    Ragsdale, Kate, Comp.

    2001-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to gather information about who has responsibility for the development, management, and maintenance of library World Wide Web sites and to determine which combination of human resources works…

  20. Telecommunications in ARL Libraries. SPEC Kit 98.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This 11-document kit introduces the current and planned uses of telecommunications facilities in the computerized information systems of several research libraries, public libraries, and library groups contacted in 1983. The first two documents are excerpts from reports on networks: "Telecommunications: An Overview for OCLC," and…

  1. Teen PACK: Population Awareness Campaign Kit.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This packet of instructional materials is designed to teach teenagers about the effects of overpopulation on the world and on the individual. Information is presented in three related booklets. The first of the three parts of the "Teen Population Awareness Campaign Kit," illustrates overpopulation through profiles of teens living in…

  2. Haitian Component Bibliography. Migrant Heritage Studies Kit.

    ERIC Educational Resources Information Center

    Roark-Calnek, Sue, Comp.

    This 587-item annotated bibliography, designed as a supplement to the Haitian Component of the Migrant Heritage Studies Kit, provides access to additional information, including audiovisual materials, on resources on Haiti and Haitian immigrants, published between 1877 and 1984. Part I is a "General Bibliography" which includes 313…

  3. Lifeprints ESL for Adults: Literacy. [Multimedia Kit].

    ERIC Educational Resources Information Center

    Cunningham Florez, MaryAnn

    Lifeprints is a four-level program that helps adult English- as-a-Second-Language (ESL) students gain the English language skills they need to participate effectively at work and in their communities. This multimedia kit contains the first level in the series. Level one is divided into six units: "Welcome to English Class"; "Personal Information";…

  4. Managing Printing Services. SPEC Kit 254.

    ERIC Educational Resources Information Center

    Blixrud, Julia C., Comp.

    2000-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit reports results of a survey that examined how Association of Research Libraries (ARL) members currently provide printing services to their users and how the costs of those services are covered. Of the 122 members surveyed, 62 responded. Included in the responses was information on main, law,…

  5. Field Test Kit for Gun Residue Detection

    SciTech Connect

    WALKER, PAMELA K.; RODACY, PHILIP J.

    2002-01-01

    One of the major needs of the law enforcement field is a product that quickly, accurately, and inexpensively identifies whether a person has recently fired a gun--even if the suspect has attempted to wash the traces of gunpowder off. The Field Test Kit for Gunshot Residue Identification based on Sandia National Laboratories technology works with a wide variety of handguns and other weaponry using gunpowder. There are several organic chemicals in small arms propellants such as nitrocellulose, nitroglycerine, dinitrotoluene, and nitrites left behind after the firing of a gun that result from the incomplete combustion of the gunpowder. Sandia has developed a colorimetric shooter identification kit for in situ detection of gunshot residue (GSR) from a suspect. The test kit is the first of its kind and is small, inexpensive, and easily transported by individual law enforcement personnel requiring minimal training for effective use. It will provide immediate information identifying gunshot residue.

  6. 49 CFR 173.161 - Chemical kits and first aid kits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Chemical kits and first aid kits. 173.161 Section... Class 7 § 173.161 Chemical kits and first aid kits. (a) Applicability. Chemical kits and first aid kits...) The kits may only contain hazardous materials for which packaging exceptions are provided in column...

  7. 49 CFR 173.161 - Chemical kits and first aid kits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Chemical kits and first aid kits. 173.161 Section... Class 7 § 173.161 Chemical kits and first aid kits. (a) Applicability. Chemical kits and first aid kits...) The kits may only contain hazardous materials for which packaging exceptions are provided in column...

  8. 49 CFR 173.161 - Chemical kits and first aid kits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Chemical kits and first aid kits. 173.161 Section... Class 7 § 173.161 Chemical kits and first aid kits. (a) Applicability. Chemical kits and first aid kits...) The kits may only contain hazardous materials for which packaging exceptions are provided in column...

  9. 49 CFR 173.161 - Chemical kits and first aid kits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Chemical kits and first aid kits. 173.161 Section... Class 7 § 173.161 Chemical kits and first aid kits. (a) Applicability. Chemical kits and first aid kits...) The kits may only contain hazardous materials for which packaging exceptions are provided in column...

  10. Molecular defects in mastocytosis: KIT and beyond KIT.

    PubMed

    Bibi, Siham; Langenfeld, Florent; Jeanningros, Sylvie; Brenet, Fabienne; Soucie, Erinn; Hermine, Olivier; Damaj, Gandhi; Dubreuil, Patrice; Arock, Michel

    2014-05-01

    In all variants of mastocytosis, activating KIT mutations are frequently found. In adults, neoplastic mast cells (MCs) cells show the KIT mutation D816V, whereas in children, MCs invading the skin are frequently positive for non-KIT D816V mutations. The clinical course and prognosis of the disease vary among patients with systemic mastocytosis (SM). Additional KIT-independent molecular defects might cause progression. Additional oncogenic lesions have recently been identified in advanced SM. In advanced SM the presence of additional genetic lesions or altered signaling worsening the prognosis might lead to the use of alternative therapies such as combined antisignaling targeted treatments or stem cell transplantation.

  11. 21 CFR 864.1860 - Immunohistochemistry reagents and kits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Immunohistochemistry reagents and kits. 864.1860 Section 864.1860 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Biological Stains §...

  12. 21 CFR 864.2260 - Chromosome culture kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Chromosome culture kit. 864.2260 Section 864.2260 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260...

  13. 21 CFR 864.2260 - Chromosome culture kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Chromosome culture kit. 864.2260 Section 864.2260 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260 Chromosome...

  14. 21 CFR 864.2260 - Chromosome culture kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Chromosome culture kit. 864.2260 Section 864.2260 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Cell And Tissue Culture Products § 864.2260 Chromosome...

  15. Telescience Resource Kit

    NASA Technical Reports Server (NTRS)

    Schneider, Michelle; Lippincott, Jeff; Chubb, Steve; Whitaker, Jimmy; Rice, Jim; Gillis, Robert; Sims, Chris; Sellers, Donna; Bailey, Darrell (Technical Monitor)

    2002-01-01

    The Telescience Resource Kit (TReK) is a PC based ground control system. It can be used by a single individual or in a group environment to monitor and control spacecraft systems and payloads. Capabilities include data receipt, data processing, data storage, data management, and data transmission. Commercial-Off-The-Shelf (COTS) hardware and software have been employed to reduce development costs, operations and maintenance costs, and to effectively take advantage of new commercial products as they become available. The TReK system is currently being used to monitor and control payloads aboard the International Space Station. It is located at sites around the world.

  16. Telescience Resource Kit

    NASA Technical Reports Server (NTRS)

    Schneider, Michelle; Lippincott, Jeff; Chubb, Steve; Whitaker, Jimmy; Rice, Jim; Gillis, Robert; Sims, Chris; Sellers, Donna; Bailey, Darrell (Technical Monitor)

    2002-01-01

    The Telescience Resource Kit (TReK) is a PC based ground control system. It can be used by a single individual or in a group environment to monitor and control spacecraft systems and payloads. Capabilities include data receipt, data processing, data storage, data management, and data transmission. Commercial-Off-The-Shelf (COTS) hardware and software have been employed to reduce development costs, operations and maintenance costs, and to effectively take advantage of new commercial products as they become available. The TReK system is currently being used to monitor and control payloads aboard the International Space Station. It is located at sites around the world.

  17. Protein crystallography prescreen kit

    DOEpatents

    Segelke, Brent W.; Krupka, Heike I.; Rupp, Bernhard

    2007-10-02

    A kit for prescreening protein concentration for crystallization includes a multiplicity of vials, a multiplicity of pre-selected reagents, and a multiplicity of sample plates. The reagents and a corresponding multiplicity of samples of the protein in solutions of varying concentrations are placed on sample plates. The sample plates containing the reagents and samples are incubated. After incubation the sample plates are examined to determine which of the sample concentrations are too low and which the sample concentrations are too high. The sample concentrations that are optimal for protein crystallization are selected and used.

  18. Protein crystallography prescreen kit

    DOEpatents

    Segelke, Brent W.; Krupka, Heike I.; Rupp, Bernhard

    2005-07-12

    A kit for prescreening protein concentration for crystallization includes a multiplicity of vials, a multiplicity of pre-selected reagents, and a multiplicity of sample plates. The reagents and a corresponding multiplicity of samples of the protein in solutions of varying concentrations are placed on sample plates. The sample plates containing the reagents and samples are incubated. After incubation the sample plates are examined to determine which of the sample concentrations are too low and which the sample concentrations are too high. The sample concentrations that are optimal for protein crystallization are selected and used.

  19. Clinical integration of picture archiving and communication systems with pathology and hospital information system in oncology.

    PubMed

    Duncan, Lisa D; Gray, Keith; Lewis, James M; Bell, John L; Bigge, Jeremy; McKinney, J Mark

    2010-09-01

    The complexity of our current healthcare delivery system has become an impediment to communication among caregivers resulting in fragmentation of patient care. To address these issues, many hospitals are implementing processes to facilitate clinical integration in an effort to improve patient care and safety. Clinical informatics, including image storage in a Picture Archiving and Communication System (PACS), represents a tool whereby clinical integration can be accomplished. In this study, we obtained intraoperative photographs of 19 cases to document clinical stage, extent of disease, disease recurrence, reconstruction/grafting, intraoperative findings not identified by preoperative imaging, and site verification as part of the Universal Protocol. Photographs from all cases were stored and viewed in PACS. Images from many of the cases were presented at our interdepartmental cancer conferences. The stored images improved communication among caregivers and preserved pertinent intraoperative findings in the patients' electronic medical record. In the future, pathology, gastroenterology, pulmonology, dermatology, and cardiology are just a few other subspecialties which could accomplish image storage in PACS. Multidisciplinary image storage in a PACS epitomizes the concept of clinical integration and its goal of improving patient care.

  20. KIT — EDRN Public Portal

    Cancer.gov

    SCF-sR, also known as KIT, is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. Human KIT is a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

  1. Pathological work up of the primary tumor: getting the proper information out of it.

    PubMed

    Viale, Giuseppe

    2011-10-01

    The primary tumour of patients with early breast cancer is the main source of information to assess the risk of disease recurrence and to inform the choice of the most appropriate systemic treatment. Accordingly, it is the main responsibility of the pathologists to ensure the patients and treating physicians that all the relevant information is derived from the primary tumour with the highest accuracy and reproducibility. The morphological changes of the tumour cells reflect the aggregate effects of changes occurring in hundreds of genes and may be a very faithful mirror of the biological and clinical behaviour of breast cancer. According to the 2009 St. Gallen Consensus, the systemic therapy of early breast cancer is mainly informed by the expression of hormone receptors and by the HER2 status, and the assessment of Ki67 has been included among the useful parameters to inform the choice of adding chemotherapy to endocrine therapies for patients with ER-positive and HER2-negative disease. A comprehensive approach that includes the accurate evaluation of the morphological features of the tumour, with special reference to the histological type and grade, and the assessment of the main prognostic and predictive parameters (ER, PgR, HER2 and Ki67) should offer to the patients and the treating physicians a robust background upon which the final therapeutic decisions can be safely taken. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Optics learning through affordable kit

    SciTech Connect

    P, Anusha N E-mail: chitrashaji@gmail.com Shaji, Chitra E-mail: chitrashaji@gmail.com Sharan, Alok E-mail: chitrashaji@gmail.com

    2014-10-15

    An affordable kit which helps to understand some of the optical phenomena qualitatively and quantitatively is presented in this paper. It supplements optics taught in classes. The kit consists of equipments which are available in the market at nominal cost such as laser pointer, lenses, glass plates, razor blades, coins, ball bearing etc. Experiments which come under wave optics (interference and diffraction) and ray optics (reflection and refraction) are explained using this kit.

  3. Education Payload Operation - Kit D

    NASA Technical Reports Server (NTRS)

    Keil, Matthew

    2009-01-01

    Education Payload Operation - Kit D (EPO-Kit D) includes education items that will be used to support the live International Space Station (ISS) education downlinks and Education Payload Operation (EPO) demonstrations onboard the ISS. The main objective of EPO-Kit D supports the National Aeronautics and Space Administration (NASA) goal of attracting students to study and seek careers in science, technology, engineering, and mathematics.

  4. Indoor Air Quality Tools for Schools Action Kit

    EPA Pesticide Factsheets

    The IAQ Tools for Schools Action Kit provides schools with information on how to carry out a practical plan to improve indoor air problems at little- or no-cost using straightforward activities and in-house staff.

  5. Frequency of black pigment in livers and spleens of coal workers: correlation with pulmonary pathology and occupational information

    SciTech Connect

    LeFevre, M.E.; Green, F.H.; Joel, D.D.; Laqueur, W.

    1982-12-01

    Histologic sections of liver and spleen from 99 retired coal workers and nine non-coal workers were obtained at autopsy and scored for black pigment. Pigment was minimal in the non-coal workers, with the exception of one person with silicosis. Moderate or heavy pigment was seen in 10.4 per cent of liver sections and 19.5 per cent of spleen sections from coal workers. The extrapulmonary pigment was not associated with any pathologic tissue response. Information on pulmonary pathology and occupational exposure to dust was available for most workers. Highly significant positive correlation was found between the severity of pneumoconiosis and the black pigment score in both liver and spleen; the correlation between emphysema and pigment score was lower, but still significant for liver. Significant positive correlations were found between years spent underground, years of retirement, and age at death versus pigment scores. Significant negative correlation was found between smoking and pigment. The positive association of extrapulmonary pigment with age at death, years of underground mining, and severity of pneumoconiosis suggests that cumulative lifetime exposure to coal mine dust may be the most important factor in the release of dust into the general circulation.

  6. Frequency of black pigment in livers and spleens of coal workers: correlation with pulmonary pathology and occupational information

    SciTech Connect

    LeFevre, M.E.; Green, F.H.Y.; Joel, D.D.; Laqueur, W.

    1982-01-01

    Histologic sections of liver and spleen from 99 retired coal workers and nine non-coal workers were obtained at autopsy and scored for black pigment. Pigment was minimal in the non-coal workers, with the exception of one person with silicosis. Moderate or heavy pigment was seen in 10.4 per cent of liver sections and 19.5 per cent of spleen sections from coal workers. The extrapulmonary pigment was not associated with any pathologic tissue response. Information on pulmonary pathology and occupational exposure to dust was available for most workers. Highly significant positive correlation was found between the severity of pnuemoconiosis and the black pigment score in both liver and spleen; the correlation between emphysema and pigment score was lower, but still significant for liver. Significant positive correlations were found between years spent underground, years of retirement, and age at death versus pigment scores. Significant negative correlation was found between smoking and pigment. The positive association of extrapulmonary pigment with age at death, years of underground mining, and severity of pneumoconiosis suggests that cumulative lifetime exposure to coal mine dust may be the most important factor in the release of dust into the general circulation.

  7. Preoperative Performance of the Patient-Reported Outcomes Measurement Information System in Patients With Rotator Cuff Pathology.

    PubMed

    Anthony, Chris A; Glass, Natalie; Hancock, Kyle; Bollier, Matt; Hettrich, Carolyn M; Wolf, Brian R

    2017-10-01

    To evaluate the Patient-Reported Outcomes Measurement Information System upper extremity item bank (PROMIS UE) and physical function computerized adaptive test (PROMIS PF CAT) in patients with rotator cuff (RC) pathology at their preoperative clinic visit. Patient data were collected from January 2015 to September 2015. Patients with a preoperative diagnosis of RC pathology were prospectively enrolled at the time of their surgical indication for RC repair. Each patient was asked to fill out the Western Ontario Rotator Cuff Index (WORC), American Shoulder and Elbow Surgeons Shoulder Assessment Form, Marx Shoulder Activity Scale, Short Form 36 Health Survey Physical Function and General Health (SF-36 PF and GH), EuroQol-5 Dimension (EQ-5D), PROMIS PF CAT, and PROMIS UE. Correlation was defined as excellent (>0.7), excellent-good (0.61-0.7), good (0.4-0.6), and poor (0.2-0.3). Patient data were collected from January 2015 to September 2015. No patients were excluded from participation in the study. In 82 patients with preoperative RC pathology, the PROMIS UE showed excellent correlation with American Shoulder and Elbow Surgeons Shoulder Assessment Form (r = 0.77, P < .01), WORC (r = 0.73, P < .01), and the EQ-5D (r = 0.73, P < .01); there was excellent-good correlation with the SF-36 PF (r = .66, P < .01) and PROMIS PF CAT (r = .70, P < .01). The PROMIS PF CAT showed excellent correlation with the SF-36 PF (r = 0.77, P < .01); there was excellent-good correlation with EQ-5D (r = 0.65, P < .01) and WORC (r = 0.61, P < .01). There were no significant floor or ceiling effects using the PROMIS UE item bank or PROMIS PF CAT. We report that in a patient population with preoperative RC pathology, the PROMIS UE and PROMIS CAT are valid patient-reported outcome alternatives that have high correlation with traditional shoulder and upper extremity patient-reported outcomes. We find a decreased question burden using the PROMIS PF CAT. We find no significant floor or

  8. Workshop Training Kits. Volume II.

    ERIC Educational Resources Information Center

    Ward, Ted; And Others

    Presented in the second of a two volume series are six workshop training kits for development of teacher skills to be used with learning disabled (LD) children. The first section of each kit contains a leader's guide which gives activity, objectives, teacher prerequisites, time required, materials needed, step-by-step procedures, a discussion…

  9. Organization Charts. SPEC Kit 1.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit, containing organization charts for 15 member libraries of the Association of Research Libraries (ARL), is a revised and updated version of a 1973 kit. In addition to charts of the total organization, many institutions have supplied charts for specific departments such as circulation, acquisitions, catalog, business, and technical…

  10. Improve Quality: Use Tool Kits.

    ERIC Educational Resources Information Center

    Gartner, Sue

    2001-01-01

    Addresses issues of defining quality in both business and community service. Describes the use of a regulatory tool kit containing rules and regulations a child care center must follow to ensure children's health, safety, and well-being. Specific tool kit types described include regulatory, government funded, rating scale, and NAEYC. (SD)

  11. International Literacy Day Tool Kit.

    ERIC Educational Resources Information Center

    2002

    This tool kit suggests various International Literacy Day activities to raise awareness of the issues of adult literacy and language learning, to connect local literacy programs with national programs, and to help achieve the National Literacy Summit goal by 2010. The kit is intended for individuals, programs, and organizations that want to call…

  12. Planning Systems. SPEC Kit 13.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit on planning systems updates a 1974 Management Studies Office Systems and Procedures Exchange Center (SPEC) kit in which developments in planning activities among Association of Research Libraries (ARL) were reviewed. At the time of the original study, in 1972, planning techniques and systems were a subject of much interest because rising…

  13. First Follow Nature, Kit II.

    ERIC Educational Resources Information Center

    1971

    Developing pupils' awareness of their environment, learning to distinguish between what is pleasant and unpleasant, and examining acts of man to determine which are destructive and which are in harmony with nature are the purposes of Scholastic's Earth Corps Environmental Study Kits for Grades 1-6. This kit explores in depth the reasons some…

  14. Look Around You, Kit I.

    ERIC Educational Resources Information Center

    1971

    Developing pupils' awareness of their environment, learning to distinguish between what is pleasant and unpleasant, and examining acts of man to determine which are destructive and which are in harmony with nature are the purposes of Scholastic's Earth Corps Environmental Study Kits for grades 1-6. This kit is designed to help the child develop…

  15. Affirmative Action. SPEC Kit 4.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Systems and Procedures Exchange Center (SPEC) kit on affirmative action programs contains planning documents and policy statements on affirmative action and equal employment opportunity from universities and Association of Research Libraries (ARL) member libraries. The kit comprises: (1) "Affirmative Action Plan for the University Library"…

  16. Improve Quality: Use Tool Kits.

    ERIC Educational Resources Information Center

    Gartner, Sue

    2001-01-01

    Addresses issues of defining quality in both business and community service. Describes the use of a regulatory tool kit containing rules and regulations a child care center must follow to ensure children's health, safety, and well-being. Specific tool kit types described include regulatory, government funded, rating scale, and NAEYC. (SD)

  17. Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain

    PubMed Central

    Aldinger, Kimberly A.; Elsen, Gina E.; Prince, Victoria E.; Millen, Kathleen J.

    2009-01-01

    Congenital malformations the human hindbrain, including the cerebellum, are poorly understood largely because their recognition is a relatively recent advance for imaging diagnostics. Cerebellar malformations are the most obvious and best characterized hindbrain malformations due to their relative ease to view by MRI and the recent identification of several causative genes1. Malformations of the pons and medulla have also been described both in isolation and in association with cerebellar malformations2. Although little is understood regarding the specific developmental pathologies underlying hindbrain malformations in humans, much is known regarding the mechanisms and genes driving hindbrain development in vertebrate model organisms. Thus, studies in vertebrate models provide a developmental framework in which to categorize human hindbrain malformations and serve to inform our thinking regarding disrupted developmental processes and candidate genes. Here we survey the basic principles of vertebrate hindbrain development and integrate our current knowledge of human hindbrain malformations into this framework. PMID:19778712

  18. [Information and worry among patients with non-oncohematological pathologies upon arrival at the hematology clinic].

    PubMed

    Rodríguez, J N; Quesada, J A; Sánchez, J L; Martino, M L; Prados, D

    1999-10-01

    Patients are frequently referred to the haematologist to be studied due to the presence of processes that are not properly haematological. We have studied the group of outpatients with non-oncohaematological pathologies referred to our external haematology clinic to evaluate their knowledge about the reason for consultation, the existence or not of worry upation and its degree at the arrival. We have made a prospective study including all patients with non-oncohaematological processes (n = 204) who were referred for the first time to our external consultation between April and October 1997. We evaluated in each patient, using an inquest, the following data: age, sex, origin (hospital consultations or urban or rural health centres), reason for consultation, knowledge of the reason for consultation (yes/partially/no), existence or not of worry (yes/no) and when present, its degree (low, moderate, high). The inquiry was made to the parents in those patients aged under 12 years. We have analyzed all adults, each group of adult patients (rural, urban, hospital) separately and compared one group to each other, all pediatric patients and we have compared as well the overall results obtained with adult patients with those from the parents of pediatric patients. 1) Adult patients (n = 169; 78 referred from hospital, 59 from urban and 32 from rural health centres): with respect to the knowledge of the reason for consultation 49.7% of them knew it perfectly, 20.1% partially, and 30.2% did not know about it. 48.5% of patients arrived worried to the clinic, 16.6% of them with a high degree, 17.8% moderate and 14.2% low. 2) Adults referred from primary health care (urban versus rural health centres): We have found neither significant differences in the knowledge of the reason for consultation, worry or its degree with respect to age, sex or origin (urban or rural), nor in the worry or its degree with respect to the patient knowledge of the reason for consultation. 3) Adults

  19. Optimizing Medical Kits for Spaceflight

    NASA Technical Reports Server (NTRS)

    Keenan, A. B,; Foy, Millennia; Myers, G.

    2014-01-01

    The Integrated Medical Model (IMM) is a probabilistic model that estimates medical event occurrences and mission outcomes for different mission profiles. IMM simulation outcomes describing the impact of medical events on the mission may be used to optimize the allocation of resources in medical kits. Efficient allocation of medical resources, subject to certain mass and volume constraints, is crucial to ensuring the best outcomes of in-flight medical events. We implement a new approach to this medical kit optimization problem. METHODS We frame medical kit optimization as a modified knapsack problem and implement an algorithm utilizing a dynamic programming technique. Using this algorithm, optimized medical kits were generated for 3 different mission scenarios with the goal of minimizing the probability of evacuation and maximizing the Crew Health Index (CHI) for each mission subject to mass and volume constraints. Simulation outcomes using these kits were also compared to outcomes using kits optimized..RESULTS The optimized medical kits generated by the algorithm described here resulted in predicted mission outcomes more closely approached the unlimited-resource scenario for Crew Health Index (CHI) than the implementation in under all optimization priorities. Furthermore, the approach described here improves upon in reducing evacuation when the optimization priority is minimizing the probability of evacuation. CONCLUSIONS This algorithm provides an efficient, effective means to objectively allocate medical resources for spaceflight missions using the Integrated Medical Model.

  20. A Java commodity grid kit.

    SciTech Connect

    von Laszewski, G.; Foster, I.; Gawor, J.; Lane, P.; Mathematics and Computer Science

    2001-07-01

    In this paper we report on the features of the Java Commodity Grid Kit. The Java CoG Kit provides middleware for accessing Grid functionality from the Java framework. Java CoG Kit middleware is general enough to design a variety of advanced Grid applications with quite different user requirements. Access to the Grid is established via Globus protocols, allowing the Java CoG Kit to communicate also with the C Globus reference implementation. Thus, the Java CoG Kit provides Grid developers with the ability to utilize the Grid, as well as numerous additional libraries and frameworks developed by the Java community to enable network, Internet, enterprise, and peer-to peer computing. A variety of projects have successfully used the client libraries of the Java CoG Kit to access Grids driven by the C Globus software. In this paper we also report on the efforts to develop server side Java CoG Kit components. As part of this research we have implemented a prototype pure Java resource management system that enables one to run Globus jobs on platforms on which a Java virtual machine is supported, including Windows NT machines.

  1. R.E.A.D.Y.: Read, Educate and Develop Youth. Reading Plan for Michigan: Parent Information for Infants, Toddlers, and Preschoolers. Learning Begins at Birth. [Kit with Videotape and Audiotape].

    ERIC Educational Resources Information Center

    Michigan Association for the Education of Young Children, East Lansing.

    Noting the important role that parents can play in preparing their child to learn to read, the Read, Educate and Develop Youth (READY) Reading Plan for Michigan provides kits to parents of infants, toddlers, and preschoolers. The kits contain suggestions for age-appropriate activities parents can do with their children to help them learn. In…

  2. [Diffuse expression of KIT in a pulmonary artery sarcoma].

    PubMed

    Kagioka, Hitoshi; Ishitoko, Manabu; Itotani, Ryo; Suzuki, Shinko; Aihara, Kensaku; Matsumoto, Masataka; Oguma, Tsuyoshi; Takemura, Masaya; Tokuhisa, Hidetoshi; Fukui, Motonari

    2008-04-01

    A 77-year-old woman presented with hoarseness and hemoptysis. Chest CT scan revealed a mediastinal tumor in the lumen of the left pulmonary artery. A definitive diagnosis could not be made based on mediastinoscopy and thoracotomy. Eight months later, multiple nodular shadows appeared in both lung fields.Video-assisted lung biopsy showed that these nodules were lung metastases of a spindle cell sarcoma. Based on the pathological and radiological findings, a pulmonary artery sarcoma was eventually diagnosed. Interestingly, on immunohistological staining, the tumor cells were diffusely positive for KIT, which is an immunohistochemical marker of gastrointestinal stromal tumors. The patient was treated with imatinib, a KIT tyrosine kinase inhibitor; however, the tumors progressed. The relationship between pulmonary artery sarcoma and KIT requires further study.

  3. Application Kit for Federal Assistance

    EPA Pesticide Factsheets

    The Federal Grant & Cooperative Agreement Act of 1977 requires Federal agencies to use a contract to acquire property or services that directly benefit the Federal government.This letter to the applicant explains the Application Kit for Federal Assistance.

  4. Energy Management Curriculum Starter Kit

    SciTech Connect

    Turner, W.C.

    1987-02-01

    The Energy Management Curriculum Starter Kit was designed to help engineering educators develop and teach energy management courses. Montana State University and Oklahoma State University courses are embodied in the model curriculum given. The curricula offered at many other universities throughout the United States are also presented. The kit was designed specifically to train engineering students to be good energy managers. Courses at both the undergraduate and postgraduate level are presented.

  5. Lessons regarding the use of birth kits in low resource countries.

    PubMed

    Hundley, Vanora A; Avan, Bilal I; Braunholtz, David; Fitzmaurice, Ann E; Graham, Wendy J

    2011-12-01

    To synthesise implementation lessons regarding birth kits in terms of the context, the user, requirements for use and the logistics of supplying kits. The scoping review was informed through a systematic literature review; a call for information distributed to experts in maternal and child health, relevant research centres and specialist libraries; a search of the web sites of groups working in the area of maternal and child health; and data extraction from DHS surveys. Data synthesis involved the production of a simple descriptive summary of the state of knowledge regarding birth kits. The 28 articles included in the review described a total of 21 birth kits used in 40 different countries and in many cases the kits were part of a package of interventions. Although birth kits are available in more than 50 low resource countries, evidence regarding implementation is limited. Levels of birth kit use vary considerably (8-99%); with higher levels being reported where birth kits are distributed free as part of a research programme. Identifying the user of the birth kit was difficult in most reports and the evidence regarding training requirements for birth kit use was conflicting. Limited information exists regarding facilitators and barriers to birth kit use, and how birth kits fit within the wider service delivery of maternal and child health. Despite widespread use of birth kits, implementation lessons are hard to identify. The fact that birth kits are predominantly used in non-facility settings, and probably by non-skilled attendants, poses further challenges in synthesising the evidence. It would seem logical that government run programmes would increase utlisation rates; however in these countries national level data are not yet available. Such data are crucial to identifying how women obtain and use birth kits. The importance of context cannot be over emphasised, and better descriptive methods are needed to capture contextual factors that may impact on the

  6. Evaluation of the Coca-Cola company travel health kit.

    PubMed

    Harper, Lynne A; Bettinger, Julie; Dismukes, Roberta; Kozarsky, Phyllis E

    2002-01-01

    The Coca-Cola travel health kit has been used for about one decade for international travelers and required evaluation to see if the items contained were appropriate for the employees. Two hundred thirty-four travelers were sampled and filled out a voluntary survey including questions about demographic information, travel history, and usage and value of the contents of the travel health kit. One hundred eighty-one surveys were returned; 65% of the respondents were male, and the majority of travelers were between the ages of 36 and 45 years. The most useful items were analgesics and medications used for gastrointestinal problems. In general, the items identified as being the least useful were those requiring specialized use by a medical practitioner, such as needles and syringes. Suggestions of items to be added to the kit included vitamins, cough drops, sleep aids, and eye drops. A surprising result that Coca-Cola employees expressed the desire for brand name rather than generic items. Evaluation of the Coca-Cola Company travel health kit revealed it to be very useful to most corporate travelers. Suggestions that were made will be taken into consideration in designing a new kit, and consideration is being given to whether a basic travel health kit should be provided to which travelers can add other items depending on their personal needs.

  7. FUELS IN SOIL TEST KIT: FIELD USE OF DIESEL DOG SOIL TEST KITS

    SciTech Connect

    Susan S. Sorini; John F. Schabron; Joseph F. Rovani, Jr.

    2002-09-30

    Western Research Institute (WRI) has developed a new commercial product ready for technology transfer, the Diesel Dog{reg_sign} Portable Soil Test Kit, for performing analysis of fuel-contaminated soils in the field. The technology consists of a method developed by WRI (U.S. Patents 5,561,065 and 5,976,883) and hardware developed by WRI that allows the method to be performed in the field (patent pending). The method is very simple and does not require the use of highly toxic reagents. The aromatic components in a soil extract are measured by absorption at 254 nm with a field-portable photometer. WRI added significant value to the technology by taking the method through the American Society for Testing and Materials (ASTM) approval and validation processes. The method is designated as ASTM Method D 5831-96, Standard Test Method for Screening Fuels in Soils. This ASTM designation allows the method to be used for federal compliance activities. In June 2001, the Diesel Dog technology won an American Chemical Society Regional Industrial Innovations Award. To gain field experience with the new technology, Diesel Dog kits have been used for a variety of site evaluation and cleanup activities. Information gained from these activities has led to improvements in hardware configurations and additional insight into correlating Diesel Dog results with results from laboratory methods. The Wyoming Department of Environmental Quality (DEQ) used Diesel Dog Soil Test Kits to guide cleanups at a variety of sites throughout the state. ENSR, of Acton, Massachusetts, used a Diesel Dog Portable Soil Test Kit to evaluate sites in the Virgin Islands and Georgia. ChemTrack and the U.S. Army Corps of Engineers successfully used a test kit to guide excavation at an abandoned FAA fuel-contaminated site near Fairbanks, Alaska. Barenco, Inc. is using a Diesel Dog Portable Soil Test Kit for site evaluations in Canada. A small spill of diesel fuel was cleaned up in Laramie, Wyoming using a Diesel

  8. Job Analysis in ARL Libraries. SPEC Kit 135.

    ERIC Educational Resources Information Center

    Black, William K.

    This Systems and Procedures Exchange Center (SPEC) kit is based on information from 22 of the 71 Association of Research Libraries (ARL) member libraries that responded to a 1986 survey of 91 ARL academic libraries concerning the analysis of professional and non-professional positions, and on information collected from 17 additional libraries that…

  9. Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance.

    PubMed

    Gutierrez, Dario A; Muralidhar, Sathya; Feyerabend, Thorsten B; Herzig, Stephan; Rodewald, Hans-Reimer

    2015-05-05

    Obesity, insulin resistance, and related pathologies are associated with immune-mediated chronic inflammation. Kit mutant mice are protected from diet-induced obesity and associated co-morbidities, and this phenotype has previously been attributed to their lack of mast cells. We performed a comprehensive metabolic analysis of Kit-dependent Kit(W/Wv) and Kit-independent Cpa3(Cre/+) mast-cell-deficient mouse strains, employing diet-induced or genetic (Lep(Ob/Ob) background) models of obesity. Our results show that mast cell deficiency, in the absence of Kit mutations, plays no role in the regulation of weight gain or insulin resistance. Moreover, we provide evidence that the metabolic phenotype observed in Kit mutant mice, while independent of mast cells, is immune regulated. Our data underscore the value of definitive mast cell deficiency models to conclusively test the involvement of this enigmatic cell in immune-mediated pathologies and identify Kit as a key hematopoietic factor in the pathogenesis of metabolic syndrome. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Solid phase microextraction field kit

    DOEpatents

    Nunes, Peter J.; Andresen, Brian D.

    2005-08-16

    A field kit for the collection, isolation and concentration of trace amounts of high explosives (HE), biological weapons (BW) and chemical weapons (CW) residues in air, soil, vegetation, swipe, and liquid samples. The field kit includes a number of Solid Phase Microextraction (SPME) fiber and syringe assemblies in a hermetically sealed transportation container or tubes which includes a sampling port, a number of extra SPME fiber and syringe assemblies, the fiber and syringe assemblies including a protective cap for the fiber, and an extractor for the protective cap, along with other items including spare parts, protective glove, and an instruction manual, all located in an airtight container.

  11. Computational Pathology

    PubMed Central

    Louis, David N.; Feldman, Michael; Carter, Alexis B.; Dighe, Anand S.; Pfeifer, John D.; Bry, Lynn; Almeida, Jonas S.; Saltz, Joel; Braun, Jonathan; Tomaszewski, John E.; Gilbertson, John R.; Sinard, John H.; Gerber, Georg K.; Galli, Stephen J.; Golden, Jeffrey A.; Becich, Michael J.

    2016-01-01

    Context We define the scope and needs within the new discipline of computational pathology, a discipline critical to the future of both the practice of pathology and, more broadly, medical practice in general. Objective To define the scope and needs of computational pathology. Data Sources A meeting was convened in Boston, Massachusetts, in July 2014 prior to the annual Association of Pathology Chairs meeting, and it was attended by a variety of pathologists, including individuals highly invested in pathology informatics as well as chairs of pathology departments. Conclusions The meeting made recommendations to promote computational pathology, including clearly defining the field and articulating its value propositions; asserting that the value propositions for health care systems must include means to incorporate robust computational approaches to implement data-driven methods that aid in guiding individual and population health care; leveraging computational pathology as a center for data interpretation in modern health care systems; stating that realizing the value proposition will require working with institutional administrations, other departments, and pathology colleagues; declaring that a robust pipeline should be fostered that trains and develops future computational pathologists, for those with both pathology and non-pathology backgrounds; and deciding that computational pathology should serve as a hub for data-related research in health care systems. The dissemination of these recommendations to pathology and bioinformatics departments should help facilitate the development of computational pathology. PMID:26098131

  12. College Completion Tool Kit

    ERIC Educational Resources Information Center

    US Department of Education, 2011

    2011-01-01

    In March, 2009, President Obama proposed the American Graduation Initiative, which established the goal that by 2020 the United States will regain its position as the nation with the highest percentage of its population holding post-secondary degrees and credentials. The College Completion Toolkit provides information that governors and other…

  13. Extended Library Hours. SPEC Kit.

    ERIC Educational Resources Information Center

    Steele, Patricia Ann, Comp.; Walters, Carolyn, Comp.

    2001-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to provide a description of how they are responding to demands for greater hours of access and service. Survey responses indicate what hours of access and service libraries are providing and…

  14. Natural Gas Energy Educational Kit.

    ERIC Educational Resources Information Center

    American Gas Association, Arlington, VA. Educational Services.

    Prepared by energy experts and educators to introduce middle school and high school students to natural gas and its role in our society, this kit is designed to be incorporated into existing science and social studies curricula. The materials and activities focus on the origin, discovery, production, delivery, and use of natural gas. The role of…

  15. Sharing the Earth, Kit II.

    ERIC Educational Resources Information Center

    1971

    Introducing the pupil to the science of ecology is the purpose of Scholastic's Earth Corps Ecology/Conservation Study Kits for grades 3-6. Simple terms are used to show how all living things are inter-related to their environment, to demonstrate the intricate and delicate balance of nature, and to point out how man's interference with nature's…

  16. Human Conflict: A Resource Kit.

    ERIC Educational Resources Information Center

    J.B. Speed Art Museum, Louisville, KY.

    Conflict, in one form or another, eventually makes its way into the daily life of every human being. It is not just a modern problem but has existed as long as humanity itself. This classroom resource kit is designed to be used by educators wishing to teach skills of conflict avoidance, management, and resolution in their classrooms. The kit…

  17. Small Business Incubator Resource Kit.

    ERIC Educational Resources Information Center

    Small Business Administration, Washington, DC.

    This kit consists of a set of resources to assist those interested in the start-up and management (incubation) of a new business. A guide to starting and managing a small business incubator (SBI) is provided. Included in the guide are the following: a discussion of the role and characteristics of the SBI concept; guidelines for carrying out the…

  18. User Surveys. SPEC Kit 148.

    ERIC Educational Resources Information Center

    Engelbrecht, Pamela Noyes

    Based on responses to a survey of Association of Research Libraries (ARL) members in March 1988, this Systems and Procedures Exchange Center (SPEC) flyer and kit are designed to assist administrators of large academic libraries in the selection of useful methods of conducting user surveys for particular library concerns. The flyer provides a brief…

  19. Organization Charts. SPEC Kit 129.

    ERIC Educational Resources Information Center

    Hoadley, Irene B.

    This kit is based on a review of the organization charts of 86 member libraries of the Association of Research Libraries (ARL) gathered in spring 1986, compared with two earlier sets of charts published in 1973 and 1977, and contains charts of 61 of the libraries. Nearly one-fourth of the charts studied are under revision, indicating that changes…

  20. Natural Gas Energy Educational Kit.

    ERIC Educational Resources Information Center

    American Gas Association, Arlington, VA. Educational Services.

    Prepared by energy experts and educators to introduce middle school and high school students to natural gas and its role in our society, this kit is designed to be incorporated into existing science and social studies curricula. The materials and activities focus on the origin, discovery, production, delivery, and use of natural gas. The role of…

  1. Sharing the Earth, Kit II.

    ERIC Educational Resources Information Center

    1971

    Introducing the pupil to the science of ecology is the purpose of Scholastic's Earth Corps Ecology/Conservation Study Kits for grades 3-6. Simple terms are used to show how all living things are inter-related to their environment, to demonstrate the intricate and delicate balance of nature, and to point out how man's interference with nature's…

  2. Johnny Horizon Environmental Test Kit.

    ERIC Educational Resources Information Center

    Bentley, Richard; Bentley, William

    Derived from tests presently used by state and federal agencies involved with pollution detection, this Environmental Test Kit contains materials and instructions for ten experiments. Each experiment is designed to test a different aspect of air and water, to find out whether or not the air and water in the tester's immediate area has been…

  3. Work and Family Resource Kit.

    ERIC Educational Resources Information Center

    Women's Bureau (DOL), Washington, DC.

    This kit is designed to help employers understand the range of family needs emerging in the workplace and the numerous options for a company response. An introduction discusses the need for child care services, dependent care problems, and how employers respond and benefit. Sections address the following: selecting the right option in relation to…

  4. Collection Assessment. SPEC Kit 41.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Association of Research Libraries (ARL) kit on collection assessment contains the following documents: (1) "Guidelines for the Evaluation of Library Collections--Draft Copy" (Collection Development Committee, Resource Section, Resources and Technical Services Division, American Library Association); (2) "Guidelines for Collection Assessment"…

  5. Developing the Advising "Tool Kit."

    ERIC Educational Resources Information Center

    Kelly, James J.

    1988-01-01

    Developing an inventory consisting of each and every item that contributes to a total advising program is suggested. The point to be made by developing a campus "Advising Tool Kit" such as Penn State's is that advising and advisors are becoming increasingly integral to the entire educational mission of colleges and universities. (MLW)

  6. Architectural Environment: A Resource Kit.

    ERIC Educational Resources Information Center

    J.B. Speed Art Museum, Louisville, KY.

    There are many ways to approach the investigation of architecture. One can look at structural form, climate and topography, the aesthetics of style and decoration, building function, historical factors, cultural meanings, or technology and techniques associated with construction. This resource kit touches upon a few of these approaches, ranging…

  7. Approval Plans. SPEC Kit 141.

    ERIC Educational Resources Information Center

    Howard, Clinton

    This SPEC kit is based on a June 1987 survey of approval plan use by 94 members of the Association of Research Libraries. It reports on the current practices of these libraries, the perceived advantages and disadvantages of using approval plans, and the effect of increased library materials costs and library automation on such plans. It is noted…

  8. Skills Training. SPEC Kit 40.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    A 1977 Association of Research Libraries (ARL) survey investigated how libraries were training personnel for routine tasks. Of the 73 responding libraries, more than 75% (58) reported that manuals and procedural guides, along with on-the-job training, were the main methods of instruction for technical skills. Accordingly, this kit on skills…

  9. Active Parenting Now: Program Kit.

    ERIC Educational Resources Information Center

    Popkin, Michael H.

    Based largely on the theories of Alfred Adler and Rudolf Dreikurs, this parent education curriculum is a video-based interactive learning experience that teaches a comprehensive model of parenting to parents of children ages 5 to 12 years. The kit provides parents with the skills needed to help their children develop courage, responsibility, and…

  10. Higher Education Salary Evaluation Kit.

    ERIC Educational Resources Information Center

    Scott, Elizabeth L.

    The kit is the result of a study undertaken to provide a method for flagging women and minority faculty members whose salaries appear to be low compared to the salaries of white males in the same faculty who have the same attributes and experience. The recommended method also provides an estimate of what the woman's or minority individual's salary…

  11. Architectural Environment: A Resource Kit.

    ERIC Educational Resources Information Center

    J.B. Speed Art Museum, Louisville, KY.

    There are many ways to approach the investigation of architecture. One can look at structural form, climate and topography, the aesthetics of style and decoration, building function, historical factors, cultural meanings, or technology and techniques associated with construction. This resource kit touches upon a few of these approaches, ranging…

  12. Collection Assessment. SPEC Kit 41.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Association of Research Libraries (ARL) kit on collection assessment contains the following documents: (1) "Guidelines for the Evaluation of Library Collections--Draft Copy" (Collection Development Committee, Resource Section, Resources and Technical Services Division, American Library Association); (2) "Guidelines for Collection Assessment"…

  13. Performance Review. SPEC Kit 14.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit contains a collection of representative documents on performance review procedures in academic and research libraries. Multiple documents from the Pennsylvania State University Libraries include a management guide to performance evaluation, a memo on performance evaluation from the librarian, and forms and instructions for use of both the…

  14. Skills Training. SPEC Kit 40.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    A 1977 Association of Research Libraries (ARL) survey investigated how libraries were training personnel for routine tasks. Of the 73 responding libraries, more than 75% (58) reported that manuals and procedural guides, along with on-the-job training, were the main methods of instruction for technical skills. Accordingly, this kit on skills…

  15. Johnny Horizon Environmental Test Kit.

    ERIC Educational Resources Information Center

    Bentley, Richard; Bentley, William

    Derived from tests presently used by state and federal agencies involved with pollution detection, this Environmental Test Kit contains materials and instructions for ten experiments. Each experiment is designed to test a different aspect of air and water, to find out whether or not the air and water in the tester's immediate area has been…

  16. Active Parenting Now: Program Kit.

    ERIC Educational Resources Information Center

    Popkin, Michael H.

    Based largely on the theories of Alfred Adler and Rudolf Dreikurs, this parent education curriculum is a video-based interactive learning experience that teaches a comprehensive model of parenting to parents of children ages 5 to 12 years. The kit provides parents with the skills needed to help their children develop courage, responsibility, and…

  17. Cubic Unit Cell Construction Kit.

    ERIC Educational Resources Information Center

    Mattson, Bruce

    2000-01-01

    Presents instructions for building a simple interactive unit-cell construction kit that allows for the construction of simple, body-centered, and face-centered cubic lattices. The lit is built from inexpensive and readily available materials and can be built in any number of sizes. (WRM)

  18. Evaluation of America's Career Kit.

    ERIC Educational Resources Information Center

    Office of Inspector General (DOL), Washington, DC.

    The Employment and Training Administration's (ETA's) development and implementation of America's Career Kit (ACK), which is an online career development resource for individuals needing job search assistance, career guidance, salary data, and training and educational resources, was evaluated. The evaluation was designed to determine whether ACK…

  19. Forensic Pathology Education in Pathology Residency

    PubMed Central

    Ross, Wayne K.; Domen, Ronald E.

    2017-01-01

    Forensic pathology is a fundamental part of anatomic pathology training during pathology residency. However, the lack of information on forensic teaching suggests the highly variable nature of forensic education. A survey of pathology residency program directors was performed to determine key aspects of their respective forensic rotations and curriculum. A total of 38.3% of programs from across the country responded, and the survey results show 5.6% don’t require a forensic pathology rotation. In those that do, most forensic pathology rotations are 4 weeks long, are done at a medical examiner’s office, and require set prerequisites. A total of 21.1% of responding programs have residents who are not receiving documented evaluations for this rotation. While 39.6% of programs have a defined forensics curriculum, as many as 15% do not. Furthermore, nearly 43% of programs place no limit on counting forensic autopsies when applying for pathology board examinations. Our survey confirmed the inconsistent nature of forensic pathology training in resident education. Additionally, our curriculum was reorganized to create a more robust educational experience. A pre- and post-forensic lecture quiz and Resident In-Service Examination scores were analyzed to determine our curriculum’s impact and effectiveness. Analysis of our pre- and post-lecture quiz showed an improved overall average as well as an increase in Resident In-Service Examination scores, indicating improved general forensic pathology knowledge. Using this knowledge, along with changes in our curriculum, we generated a number of recommendations for improving forensic pathology education in pathology residency. PMID:28913415

  20. Recommendations for adaptation and validation of commercial kits for biomarker quantification in drug development.

    PubMed

    Khan, Masood U; Bowsher, Ronald R; Cameron, Mark; Devanarayan, Viswanath; Keller, Steve; King, Lindsay; Lee, Jean; Morimoto, Alyssa; Rhyne, Paul; Stephen, Laurie; Wu, Yuling; Wyant, Timothy; Lachno, D Richard

    2015-01-01

    Increasingly, commercial immunoassay kits are used to support drug discovery and development. Longitudinally consistent kit performance is crucial, but the degree to which kits and reagents are characterized by manufacturers is not standardized, nor are the approaches by users to adapt them and evaluate their performance through validation prior to use. These factors can negatively impact data quality. This paper offers a systematic approach to assessment, method adaptation and validation of commercial immunoassay kits for quantification of biomarkers in drug development, expanding upon previous publications and guidance. These recommendations aim to standardize and harmonize user practices, contributing to reliable biomarker data from commercial immunoassays, thus, enabling properly informed decisions during drug development.

  1. A Comparison of Cell-Free DNA Isolation Kits: Isolation and Quantification of Cell-Free DNA in Plasma.

    PubMed

    Sorber, Laure; Zwaenepoel, Karen; Deschoolmeester, Vanessa; Roeyen, Geert; Lardon, Filip; Rolfo, Christian; Pauwels, Patrick

    2017-01-01

    The analysis of cell-free DNA (cfDNA) as a sensitive biomarker for cancer diagnosis and monitoring has resulted in a need for efficient and standardized cfDNA isolation. In this study, we compared the isolation efficiency of the QIAamp circulating nucleic acid kit (QIA) with four other cfDNA isolation kits: the PME free-circulating DNA Extraction Kit (PME), the Maxwell RSC ccfDNA Plasma Kit (RSC), the EpiQuick Circulating Cell-Free DNA Isolation Kit (EQ), and two consecutive versions of the NEXTprep-Mag cfDNA Isolation Kit (NpMV1/2). cfDNA was isolated from 10 plasma samples, of which five contained KRAS mutated cell-free tumor DNA (ctDNA). Digital droplet PCR was used to quantify the total cfDNA concentration as well as the KRAS mutated ctDNA fraction. cfDNA integrity was assessed with real-time quantitative PCR. The QIA and the RSC kits displayed similar isolation efficiencies of both KRAS mutated ctDNA and nonmutated cfDNA, whereas the yield generated by the PME and NpMV2 kits was significantly lower. Real-time quantitative PCR indicated the presence of digital droplet PCR inhibiting agents in the eluates of the NpMV1 and EQ kits. To conclude, this study presents two highly efficient isolation kits for cfDNA isolation, of which the RSC kit has the advantage of a fully automated protocol over the labor-intensive QIA kit. Copyright © 2017 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  2. Basic Teaching Kit on Consumer Advertising.

    ERIC Educational Resources Information Center

    Proctor and Gamble Co., Cincinnati, OH.

    This advertising kit was developed by Procter and Gamble in response to requests from teachers and consumer educators who asked for materials from business about business. The kit is not intended to cover the entire field of advertising. Rather, it centers on advertising as it is known and practiced by Procter and Gamble. The purpose of the kit is…

  3. 47 CFR 15.25 - Kits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Kits. 15.25 Section 15.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.25 Kits. A TV interface device, including a cable system terminal device, which is marketed as a kit shall comply with...

  4. 47 CFR 15.25 - Kits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Kits. 15.25 Section 15.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.25 Kits. A TV interface device, including a cable system terminal device, which is marketed as a kit shall comply with...

  5. 47 CFR 15.25 - Kits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Kits. 15.25 Section 15.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.25 Kits. A TV interface device, including a cable system terminal device, which is marketed as a kit shall comply with...

  6. 47 CFR 15.25 - Kits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Kits. 15.25 Section 15.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.25 Kits. A TV interface device, including a cable system terminal device, which is marketed as a kit shall comply with...

  7. 47 CFR 15.25 - Kits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Kits. 15.25 Section 15.25 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.25 Kits. A TV interface device, including a cable system terminal device, which is marketed as a kit shall comply with...

  8. Migration Oz, An Investigative Resource Kit.

    ERIC Educational Resources Information Center

    History Teachers' Association of Victoria (Australia).

    This resource kit examines immigration and population issues in Australia. Many organizations with an active interest in immigration policy are represented in the kit, giving students the opportunity to evaluate alternative positions and views. The kit reflects the Commonwealth Government's multicultural policies and the goals that underlie them,…

  9. Basic Teaching Kit on Consumer Advertising.

    ERIC Educational Resources Information Center

    Proctor and Gamble Co., Cincinnati, OH.

    This advertising kit was developed by Procter and Gamble in response to requests from teachers and consumer educators who asked for materials from business about business. The kit is not intended to cover the entire field of advertising. Rather, it centers on advertising as it is known and practiced by Procter and Gamble. The purpose of the kit is…

  10. 21 CFR 876.5210 - Enema kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Enema kit. 876.5210 Section 876.5210 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Therapeutic Devices § 876.5210 Enema kit. (a) Identification. An enema kit is a...

  11. Digital Pathology: Data-Intensive Frontier in Medical Imaging: Health-information sharing, specifically of digital pathology, is the subject of this paper which discusses how sharing the rich images in pathology can stretch the capabilities of all otherwise well-practiced disciplines.

    PubMed

    Cooper, Lee A D; Carter, Alexis B; Farris, Alton B; Wang, Fusheng; Kong, Jun; Gutman, David A; Widener, Patrick; Pan, Tony C; Cholleti, Sharath R; Sharma, Ashish; Kurc, Tahsin M; Brat, Daniel J; Saltz, Joel H

    2012-04-01

    Pathology is a medical subspecialty that practices the diagnosis of disease. Microscopic examination of tissue reveals information enabling the pathologist to render accurate diagnoses and to guide therapy. The basic process by which anatomic pathologists render diagnoses has remained relatively unchanged over the last century, yet advances in information technology now offer significant opportunities in image-based diagnostic and research applications. Pathology has lagged behind other healthcare practices such as radiology where digital adoption is widespread. As devices that generate whole slide images become more practical and affordable, practices will increasingly adopt this technology and eventually produce an explosion of data that will quickly eclipse the already vast quantities of radiology imaging data. These advances are accompanied by significant challenges for data management and storage, but they also introduce new opportunities to improve patient care by streamlining and standardizing diagnostic approaches and uncovering disease mechanisms. Computer-based image analysis is already available in commercial diagnostic systems, but further advances in image analysis algorithms are warranted in order to fully realize the benefits of digital pathology in medical discovery and patient care. In coming decades, pathology image analysis will extend beyond the streamlining of diagnostic workflows and minimizing interobserver variability and will begin to provide diagnostic assistance, identify therapeutic targets, and predict patient outcomes and therapeutic responses.

  12. Musculoskeletal Pathology.

    PubMed

    Peat, Frances J; Kawcak, Christopher E

    2015-08-01

    The current understanding of pathology as it relates to common diseases of the equine musculoskeletal system is reviewed. Conditions are organized under the fundamental categories of developmental, exercise-induced, infectious, and miscellaneous pathology. The overview of developmental pathology incorporates the new classification system of juvenile osteochondral conditions. Discussion of exercise-induced pathology emphasizes increased understanding of the contribution of cumulative microdamage caused by repetitive cyclic loading. Miscellaneous musculoskeletal pathology focuses on laminitis, which current knowledge indicates should be regarded as a clinical syndrome with a variety of possible distinct mechanisms of structural failure that are outlined in this overview. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. Healthy Schools Campaign Pesticide Action Kit = Campana de Escuelas Saludables Paquete de Accion Pesticida.

    ERIC Educational Resources Information Center

    Arguello, Martha; Campbell, Kelly; Kegley, Susan; Olle, Teri; Porter, Catherine; Undem, Melanie

    This English/Spanish informational kit contains resource materials that school administrators and parents can use to take full advantage of the Healthy Schools Act of 2000 and help them eliminate hazardous pesticide use around their schools. The kit looks at how to organize community interest in least-toxic Integrated Pest Management policy, and…

  14. Life Skills Workbook: A Guide to Personal Growth. Career Survival Kit for Teen Education and Employment.

    ERIC Educational Resources Information Center

    Lindner, A. Frances

    This workbook is one component of the Career Survival Kit prepared for teenage parents in Wisconsin. Designed to be used with a companion visual," Teenage Parents; Making It Work," (one of the two visuals included in the complete kit) the workbook information and activities for teens to use to strengthen their skills in the following…

  15. The Use of "The Forest Kit" in Schools. Forestry Insights. A Report.

    ERIC Educational Resources Information Center

    Burgon, Jacky; Boyd, Sally

    "Te Ngahere, The Forest" is a kit comprised of a teacher's guide, activity cards, a resource book, a poster, and a picture pack to inform New Zealand students of forest and forestry in New Zealand. This document reports results of a mail survey to determine the number of teachers and schools with knowledge of the kit, the extent of that…

  16. Introductory Guide: How To Use This Kit. Job Match: Together for Good Business.

    ERIC Educational Resources Information Center

    Rood, Lois

    Intended for use with business and industry personnel, the guide is part of a kit designed to demonstrate how individuals with disabilities and older persons can be assimilated successfully into the labor force. Individual sections of the guide provide information on: (1) purpose of the training kit; (2) people with special needs defined (labels…

  17. South Africa on the Move. A Tool Kit for Education and Action.

    ERIC Educational Resources Information Center

    CUSO Development Education, Ottawa (Ontario).

    This kit provides materials about South Africa for activists and educators and the Canadian public. The materials provide ideas for communicating the information and moving people to action. They include a user's guide with a kit overview and suggestions for its use; an educator's handbook on South Africa, which applies a popular education…

  18. Tickle Your Appetite: WIC/Team Nutrition Educator's Kit for Children.

    ERIC Educational Resources Information Center

    Food and Consumer Service (USDA), Washington, DC.

    Intended for use by WIC nutrition educators and other professionals, by day care and Head Start providers, and for home use, this educator's kit contains activities and information to improve nutrition experiences for preschool-age children. In addition to the educator's guide, the kit includes a short videotape and audiotape with three segments…

  19. Validation of Patient-Reported Outcomes Measurement Information System Computerized Adaptive Tests Against the Foot and Ankle Outcome Score for 6 Common Foot and Ankle Pathologies.

    PubMed

    Koltsov, Jayme C B; Greenfield, Stephen T; Soukup, Dylan; Do, Huong T; Ellis, Scott J

    2017-08-01

    The field of foot and ankle surgery lacks a widely accepted gold-standard patient-reported outcome instrument. With the changing infrastructure of the medical profession, more efficient patient-reported outcome tools are needed to reduce respondent burden and increase participation while providing consistent and reliable measurement across multiple pathologies and disciplines. The primary purpose of the present study was to validate 3 Patient-Reported Outcomes Measurement Information System computer adaptive tests (CATs) most relevant to the foot and ankle discipline against the Foot and Ankle Outcome Score (FAOS) and the Short Form 12 general health status survey in patients with 6 common foot and ankle pathologies. Patients (n = 240) indicated for operative treatment for 1 of 6 common foot and ankle pathologies completed the CATs, FAOS, and Short Form 12 at their preoperative surgical visits, 1 week subsequently (before surgery), and at 6 months postoperatively. The psychometric properties of the instruments were assessed and compared. The Patient-Reported Outcomes Measurement Information System CATs each took less than 1 minute to complete, whereas the FAOS took 6.5 minutes, and the Short Form 12 took 3 minutes. CAT scores were more normally distributed and had fewer floor and ceiling effects than those on the FAOS, which reached as high as 24%. The CATs were more precise than the FAOS and had similar responsiveness and test-retest reliability. The physical function and mobility CATs correlated strongly with the activities subscale of the FAOS, and the pain interference CAT correlated strongly with the pain subscale of the FAOS. The CATs and FAOS were responsive to changes with operative treatment for 6 common foot and ankle pathologies. The CATs performed as well as or better than the FAOS in all aspects of psychometric validity. The Patient-Reported Outcomes Measurement Information System CATs show tremendous potential for improving the study of patient

  20. Women's Energy Tool Kit: Home Heating, Cooling and Weatherization.

    ERIC Educational Resources Information Center

    Byalin, Joan

    This book is the first in a series of Energy Tool Kits designed for women by Consumer Action Now, a non-profit organization devoted to promoting energy efficiency and renewable energy resources. Information is provided in 16 sections: introduction, home energy survey; caulking; weatherstripping (double-hung and sliding windows, and casement,…

  1. Women and the Military. A WEAL Fund Kit.

    ERIC Educational Resources Information Center

    Women's Equity Action League Educational and Legal Defense Fund, Washington, DC.

    Designed to provide useful information on women in the military, this kit is intended for students, teachers, guidance counselors, parents, policy officials, women's studies programs, librarians, and those interested in the changing role of women. The first section includes a paper on Common Misconceptions about Women in the Military and issue…

  2. Mental Health Issues on Campus: A Resource Kit for Staff.

    ERIC Educational Resources Information Center

    Andrews, Jana; McLean, Patricia

    This resource kit provides information intended to assist Australian disability liaison officers (DLO) and others who work with college students with psychiatric disabilities to understand the effects of mental health issues on learning in the context of post-secondary education. The guide suggests a range of compensatory strategies that aim to…

  3. Managing Copy Cataloging in ARL Libraries. SPEC Kit 136.

    ERIC Educational Resources Information Center

    Clark, Sharon E.

    This Systems and Procedures Evaluation Center (SPEC) kit is based on information and documents submitted by 15 Association of Research Library (ARL) member libraries in response to an August 1986 questionnaire mailed to 19 ARL libraries selected on the basis of their size, level of automation, and organizational structure of copy cataloging. A…

  4. National High Blood Pressure 12-Month Kit. May 1988.

    ERIC Educational Resources Information Center

    National Heart and Lung Inst. (DHHS/NIH), Bethesda, MD. National High Blood Pressure Education Program.

    Part I of this kit provides information for program planners and health professionals on ways to overcome barriers to health care among the medically underserved, promote high blood pressure control through the media and other community channels, and improve adherence to treatment among hypertensive patients. It lists additional resources for…

  5. Enhancing Science Kits with the Driving Question Board

    ERIC Educational Resources Information Center

    Nordine, Jeff; Torres, Ruben

    2013-01-01

    This article describes the driving question board (DQB), a visual organizer that supports inquiry-based instruction through the use of guiding questions. The DQB is a teaching aid designed to increase student engagement alongside science kits. Information is provided on its application to a lesson on buoyancy, highlighting how it improved…

  6. Enhancing Science Kits with the Driving Question Board

    ERIC Educational Resources Information Center

    Nordine, Jeff; Torres, Ruben

    2013-01-01

    This article describes the driving question board (DQB), a visual organizer that supports inquiry-based instruction through the use of guiding questions. The DQB is a teaching aid designed to increase student engagement alongside science kits. Information is provided on its application to a lesson on buoyancy, highlighting how it improved…

  7. Insuring and Valuing Research Library Collections. SPEC Kit.

    ERIC Educational Resources Information Center

    Martin, Susan K., Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to investigate what methods are used to value or appraise research library collections, in order to provide librarians with information useful to them in discussing these issues with their…

  8. National Radon Awareness Month - Event Planning Kit Document

    EPA Pesticide Factsheets

    Individuals, groups, and organizations are the driving force in getting the message out to the public about the dangers of indoor radon. You will find information and materials in this Kit that you can use to get the word out about radon.

  9. Insuring and Valuing Research Library Collections. SPEC Kit.

    ERIC Educational Resources Information Center

    Martin, Susan K., Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to investigate what methods are used to value or appraise research library collections, in order to provide librarians with information useful to them in discussing these issues with their…

  10. Bears. Interactive Animal Kit. Grades 1-3.

    ERIC Educational Resources Information Center

    Bernard, Robin

    This kit was created to make learning about bears a fun and meaningful experience for teachers and students. It offers students opportunities to learn about favorite animals through an assortment of fun activities filled with information. The activities interact with science, language arts, critical thinking, music, social studies, math, art, and…

  11. Managing Copy Cataloging in ARL Libraries. SPEC Kit 136.

    ERIC Educational Resources Information Center

    Clark, Sharon E.

    This Systems and Procedures Evaluation Center (SPEC) kit is based on information and documents submitted by 15 Association of Research Library (ARL) member libraries in response to an August 1986 questionnaire mailed to 19 ARL libraries selected on the basis of their size, level of automation, and organizational structure of copy cataloging. A…

  12. Bears. Interactive Animal Kit. Grades 1-3.

    ERIC Educational Resources Information Center

    Bernard, Robin

    This kit was created to make learning about bears a fun and meaningful experience for teachers and students. It offers students opportunities to learn about favorite animals through an assortment of fun activities filled with information. The activities interact with science, language arts, critical thinking, music, social studies, math, art, and…

  13. The FOT tool kit concept

    NASA Technical Reports Server (NTRS)

    Fatig, Michael

    1993-01-01

    Flight operations and the preparation for it has become increasingly complex as mission complexities increase. Further, the mission model dictates that a significant increase in flight operations activities is upon us. Finally, there is a need for process improvement and economy in the operations arena. It is therefore time that we recognize flight operations as a complex process requiring a defined, structured, and life cycle approach vitally linked to space segment, ground segment, and science operations processes. With this recognition, an FOT Tool Kit consisting of six major components designed to provide tools to guide flight operations activities throughout the mission life cycle was developed. The major components of the FOT Tool Kit and the concepts behind the flight operations life cycle process as developed at NASA's GSFC for GSFC-based missions are addressed. The Tool Kit is therefore intended to increase productivity, quality, cost, and schedule performance of the flight operations tasks through the use of documented, structured methodologies; knowledge of past lessons learned and upcoming new technology; and through reuse and sharing of key products and special application programs made possible through the development of standardized key products and special program directories.

  14. Differential Use of Elementary Science Kits

    NASA Astrophysics Data System (ADS)

    Jones, Gail; Robertson, Laura; Gardner, Grant E.; Dotger, Sharon; Blanchard, Margaret R.

    2012-10-01

    The use of kits in elementary science classes is a growing trend in some countries. Kits provide materials and inquiry lessons in a ready-to-teach format for teachers to use in their science instruction. This study examined elementary teachers' instructional strategies, classroom practices, and assessment types in relation to the frequency of science kit use. A total of 503 elementary teachers from an urban school district received professional development, implemented kits in their classrooms for a year, and then completed a survey about science kit use and teaching practices. Despite similarities in demographic characteristics (gender, ethnicity, certification/educational level), there were significant differences in teachers' use of inquiry-based teaching and assessment practices by kit use. Teachers who reported using kits the most often were significantly more likely to report that their students designed and implemented laboratory investigations as well recorded, represented, and analyzed data. In addition, the high kit users indicated that they were more likely to use student groups, require students to use evidence to support claims, and use alternative assessments of student work including portfolios, notebooks, and long-term projects than those teachers who used kits less frequently. Those teachers who reported using kits the least often were significantly more likely to report having students practice for standardized tests. The role of kits in promoting reform-based teaching practices is discussed.

  15. The Virtual Physiological Human ToolKit.

    PubMed

    Cooper, Jonathan; Cervenansky, Frederic; De Fabritiis, Gianni; Fenner, John; Friboulet, Denis; Giorgino, Toni; Manos, Steven; Martelli, Yves; Villà-Freixa, Jordi; Zasada, Stefan; Lloyd, Sharon; McCormack, Keith; Coveney, Peter V

    2010-08-28

    The Virtual Physiological Human (VPH) is a major European e-Science initiative intended to support the development of patient-specific computer models and their application in personalized and predictive healthcare. The VPH Network of Excellence (VPH-NoE) project is tasked with facilitating interaction between the various VPH projects and addressing issues of common concern. A key deliverable is the 'VPH ToolKit'--a collection of tools, methodologies and services to support and enable VPH research, integrating and extending existing work across Europe towards greater interoperability and sustainability. Owing to the diverse nature of the field, a single monolithic 'toolkit' is incapable of addressing the needs of the VPH. Rather, the VPH ToolKit should be considered more as a 'toolbox' of relevant technologies, interacting around a common set of standards. The latter apply to the information used by tools, including any data and the VPH models themselves, and also to the naming and categorizing of entities and concepts involved. Furthermore, the technologies and methodologies available need to be widely disseminated, and relevant tools and services easily found by researchers. The VPH-NoE has thus created an online resource for the VPH community to meet this need. It consists of a database of tools, methods and services for VPH research, with a Web front-end. This has facilities for searching the database, for adding or updating entries, and for providing user feedback on entries. Anyone is welcome to contribute.

  16. Kit and c-kit mutations in mastocytosis: a short overview with special reference to novel molecular and diagnostic concepts.

    PubMed

    Féger, Frédéric; Ribadeau Dumas, Antoine; Leriche, Laurence; Valent, Peter; Arock, Michel

    2002-02-01

    Mastocytosis is a heterogeneous group of hematopoietic disorders characterized by abnormal growth and accumulation of mast cells (MC) in one or more organs. Clinical symptoms occur as a result of the release of chemical mediators and/or of pathologic infiltration of MC in various tissues. Although the initial events leading to mastocytosis have not yet been unraveled, acquired alterations in the c-kit gene coding for the receptor of stem cell factor (SCF), a major cytokine involved in MC growth, have been described in a significant number of patients. Of particular interest are point mutations resulting in a constitutively activated SCF receptor. Such mutations are probably involved in the abnormal (SCF-independent) proliferation of MC in these patients. New therapeutic strategies may be envisaged to inhibit the deregulated kinase activity of these mutant forms of c-kit.

  17. Genetic interaction between Kit and Scl

    PubMed Central

    Lacombe, Julie; Krosl, Gorazd; Tremblay, Mathieu; Gerby, Bastien; Martin, Richard; Aplan, Peter D.; Lemieux, Sebastien

    2013-01-01

    SCL/TAL1, a tissue-specific transcription factor of the basic helix-loop-helix family, and c-Kit, a tyrosine kinase receptor, control hematopoietic stem cell survival and quiescence. Here we report that SCL levels are limiting for the clonal expansion of Kit+ multipotent and erythroid progenitors. In addition, increased SCL expression specifically enhances the sensitivity of these progenitors to steel factor (KIT ligand) without affecting interleukin-3 response, whereas a DNA-binding mutant antagonizes KIT function and induces apoptosis in progenitors. Furthermore, a twofold increase in SCL levels in mice bearing a hypomorphic Kit allele (W41/41) corrects their hematocrits and deficiencies in erythroid progenitor numbers. At the molecular level, we found that SCL and c-Kit signaling control a common gene expression signature, of which 19 genes are associated with apoptosis. Half of those were decreased in purified megakaryocyte/erythroid progenitors (MEPs) from W41/41 mice and rescued by the SCL transgene. We conclude that Scl operates downstream of Kit to support the survival of MEPs. Finally, higher SCL expression upregulates Kit in normal bone marrow cells and increases chimerism after bone marrow transplantation, indicating that Scl is also upstream of Kit. We conclude that Scl and Kit establish a positive feedback loop in multipotent and MEPs. PMID:23836559

  18. Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: a systematic review and meta-analysis

    PubMed Central

    Yan, Lin; Zou, Lei; Zhao, Wenhua; Wang, Yansen; Liu, Bo; Yao, Hongliang; Yu, Haihua

    2015-01-01

    Many types of KIT mutations have been observed in gastrointestinal stromal tumors (GISTs), but their prognostic and predictive significance are still unclear. A meta-analysis and literature review were conducted to estimate the contribution of KIT mutations in prognostic parameters and clinic-pathological significance of GISTs. A total of 18 relevant articles from PubMed, EMBASE and Web of Science databases were included in this study. The frequency of KIT mutation was significantly increased in the GIST patients with higher mitosis (≥5/50 high-power fields (HPFs) and larger size (≥5 cm) of tumors than in those with lower MI (≤5/50HPFs) and smaller size (≤5 cm) of GISTs respectively. The rate of KIT mutation was not significantly changed between GISTs in stomachs and in small intestines. KIT mutational status has prognostic significance for patients’ outcome. GIST patients with KIT exon 9 mutations have higher risk of progression than those with exon 11 mutations. 5 year relapse-free survival (RFS) rate was significantly higher in patients with KIT exon 11 deletion than in those with other type of KIT exon 11 mutations. The deletion involving KIT exon 11, particularly codons 557–558, is a valuable predictor of prognosis for patients with GISTs. PMID:26349547

  19. Molecular alterations of KIT oncogene in gliomas.

    PubMed

    Gomes, Ana L; Reis-Filho, Jorge S; Lopes, José M; Martinho, Olga; Lambros, Maryou B K; Martins, Albino; Schmitt, Fernando; Pardal, Fernando; Reis, Rui M

    2007-01-01

    Gliomas are the most common and devastating primary brain tumours. Despite therapeutic advances, the majority of gliomas do not respond either to chemo or radiotherapy. KIT, a class III receptor tyrosine kinase (RTK), is frequently involved in tumourigenic processes. Currently, KIT constitutes an attractive therapeutic target. In the present study we assessed the frequency of KIT overexpression in gliomas and investigated the genetic mechanisms underlying KIT overexpression. KIT (CD117) immunohistochemistry was performed in a series of 179 gliomas of various grades. KIT activating gene mutations (exons 9, 11, 13 and 17) and gene amplification analysis, as defined by chromogenic in situ hybridization (CISH) and quantitative real-time PCR (qRT-PCR) were performed in CD117 positive cases. Tumour cell immunopositivity was detected in 15.6% (28/179) of cases, namely in 25% (1/4) of pilocytic astrocytomas, 25% (5/20) of diffuse astrocytomas, 20% (1/5) of anaplastic astrocytomas, 19.5% (15/77) of glioblastomas and one third (3/9) of anaplastic oligoastrocytomas. Only 5.7% (2/35) of anaplastic oligodendrogliomas showed CD117 immunoreactivity. No association was found between tumour CD117 overexpression and patient survival. In addition, we also observed CD117 overexpression in endothelial cells, which varied from 0-22.2% of cases, being more frequent in high-grade lesions. No KIT activating mutations were identified. Interestingly, CISH and/or qRT-PCR analysis revealed the presence of KIT gene amplification in 6 glioblastomas and 2 anaplastic oligoastrocytomas, corresponding to 33% (8/24) of CD117 positive cases. In conclusion, our results demonstrate that KIT gene amplification rather than gene mutation is a common genetic mechanism underlying KIT expression in subset of malignant gliomas. Further studies are warranted to determine whether glioma patients exhibiting KIT overexpression and KIT gene amplification may benefit from therapy with anti-KIT RTK inhibitors.

  20. Mass and Volume Optimization of Space Flight Medical Kits

    NASA Technical Reports Server (NTRS)

    Keenan, A. B.; Foy, Millennia Hope; Myers, Jerry

    2014-01-01

    Resource allocation is a critical aspect of space mission planning. All resources, including medical resources, are subject to a number of mission constraints such a maximum mass and volume. However, unlike many resources, there is often limited understanding in how to optimize medical resources for a mission. The Integrated Medical Model (IMM) is a probabilistic model that estimates medical event occurrences and mission outcomes for different mission profiles. IMM simulates outcomes and describes the impact of medical events in terms of lost crew time, medical resource usage, and the potential for medically required evacuation. Previously published work describes an approach that uses the IMM to generate optimized medical kits that maximize benefit to the crew subject to mass and volume constraints. We improve upon the results obtained previously and extend our approach to minimize mass and volume while meeting some benefit threshold. METHODS We frame the medical kit optimization problem as a modified knapsack problem and implement an algorithm utilizing dynamic programming. Using this algorithm, optimized medical kits were generated for 3 mission scenarios with the goal of minimizing the medical kit mass and volume for a specified likelihood of evacuation or Crew Health Index (CHI) threshold. The algorithm was expanded to generate medical kits that maximize likelihood of evacuation or CHI subject to mass and volume constraints. RESULTS AND CONCLUSIONS In maximizing benefit to crew health subject to certain constraints, our algorithm generates medical kits that more closely resemble the unlimited-resource scenario than previous approaches which leverage medical risk information generated by the IMM. Our work here demonstrates that this algorithm provides an efficient and effective means to objectively allocate medical resources for spaceflight missions and provides an effective means of addressing tradeoffs in medical resource allocations and crew mission success

  1. Prediction of biochemical recurrence and prostate cancer specific death in men after radical retropublic prostatectomy: Use of pathology and computer-assisted quantitative nuclear grading information

    NASA Astrophysics Data System (ADS)

    Khan, Masood Ahmed

    easy to use nomogram that can provide information on the likeHhood of biochemical recurrence based on pathological variables, surgical margin status and Gleason score; 4) We have demonstrated that nuclear morphometric information obtained from cancer areas in pathological specimens as well as cancer and normal areas from tissue microarrays can provide information on the likelihood of progressing further after the presence of biochemical recurrence. Furthermore, nuclear morphometry can provide greater information on the likelihood of disease recurrence than pathological variables.

  2. KIT amplification and gene mutations in acral/mucosal melanoma in Korea.

    PubMed

    Yun, Jina; Lee, Jeeyun; Jang, Jiryeon; Lee, Eui Jin; Jang, Kee Taek; Kim, Jung Han; Kim, Kyoung-Mee

    2011-06-01

    Mucosal and acral melanomas have demonstrated different genetic alterations and biological behavior compared with more common cutaneous melanomas. It was recently reported that gain-of-function KIT mutations and/or copy number increases are more common in mucosal and acral melanomas. Thus, we studied the frequency and pattern of KIT aberrations in mucosal and acral melanomas in Korea. We analyzed 97 patients who were pathologically confirmed with mucosal or acral melanoma between 1997 and 2010 at Samsung Medical Center. Of the 97 melanoma patients, 92 were screened for mutations in KIT exons 11, 13, 17, and 18, BRAF and NRAS genes. KIT copy number was assessed by quantitative, real-time PCR. Of the 97 patients, 55 (56.7%) were mucosal, 40 (41.2%) were acral melanoma, and two were of unknown primary origin. Among seven cases with KIT mutation, five (60.0%) occurred in exon 11, one (20.0%) in exon 17, and one (20.0%) in exon 13. Point mutations were the most common, resulting in substitutions in exon 11 (K558R, T574A, L576P, and V559A), exon 13 (N655K), and exon 17 (N822K). A novel Thr574Ala (c.1720A>G) KIT mutation, which has not been reported in melanoma or other tumor types, was identified in one genital melanoma case. Of the 97 mucosal or acral melanoma specimens, 49 were tested for KIT gene copy number changes using quantitative PCR. Increased KIT copy number was identified in 15 patients: seven (40%) of 20 acral melanomas and eight (31%) of 26 mucosal melanomas. Our study implicates that a significant proportion of acral and mucosal melanomas have KIT mutations in Asian population.

  3. Selecting patients for KIT inhibition in melanoma.

    PubMed

    Carvajal, Richard D; Hamid, Omid; Antonescu, Cristina R

    2014-01-01

    For many years, melanoma has been regarded as a single disease in terms of therapeutic considerations. The more recent identification of multiple molecular mechanisms underlying the development, progression, and prognosis of melanoma has led to a new paradigm for the management of this disease, has created new therapeutic opportunities, and has led to improved clinical outcomes. Such advances, however, are dependent upon methods that can reproducibly identify key molecular alterations within an individual tumor, define clinically relevant genetic subgroups of disease, and permit improved patient selection for targeted therapies.Melanomas harboring genetic alterations of KIT have been demonstrated to constitute one such molecular subgroup of disease. In this chapter, we will discuss the biology of KIT in melanoma, review the rationale for and clinical data regarding KIT inhibition in melanomas harboring activating alterations of KIT, propose guidelines for the selection of patients for KIT inhibitor therapy, and, finally, present laboratory methods for KIT assessment in melanoma.

  4. [An analysis of the information system controlling the status of the normal skin microflora and in pathology].

    PubMed

    Mal'tsev, V N; Shlip, M; Saadawi, A; Aiyada, A; Elgaui, O; Belaza, A; Tekhdi, M

    1995-01-01

    The skin microflora of healthy adults and patients with acute respiratory diseases has been studied. As revealed in this study, the optimum conditions for functioning the information system are observed in summer. After the action of unfavorable factors the activity of the system deteriorates due to the appearance of disturbances in the paths of the transmission of information. In response, the content of general information in the system increases, while the volume of useful information, necessary for the realization of the effector function, decreases. To stabilize its activity, the system spends its information reserves. These changes in the activity of the system, controlling the permanence of microflora and immunity, are slightly pronounced in winter and reach their maximum manifestation at the peak of acute respiratory disease.

  5. Pathology informatics fellowship training: Focus on molecular pathology

    PubMed Central

    Mandelker, Diana; Lee, Roy E.; Platt, Mia Y.; Riedlinger, Gregory; Quinn, Andrew; Rao, Luigi K. F.; Klepeis, Veronica E.; Mahowald, Michael; Lane, William J.; Beckwith, Bruce A.; Baron, Jason M.; McClintock, David S.; Kuo, Frank C.; Lebo, Matthew S.; Gilbertson, John R.

    2014-01-01

    Background: Pathology informatics is both emerging as a distinct subspecialty and simultaneously becoming deeply integrated within the breadth of pathology practice. As specialists, pathology informaticians need a broad skill set, including aptitude with information fundamentals, information systems, workflow and process, and governance and management. Currently, many of those seeking training in pathology informatics additionally choose training in a second subspecialty. Combining pathology informatics training with molecular pathology is a natural extension, as molecular pathology is a subspecialty with high potential for application of modern biomedical informatics techniques. Methods and Results: Pathology informatics and molecular pathology fellows and faculty evaluated the current fellowship program's core curriculum topics and subtopics for relevance to molecular pathology. By focusing on the overlap between the two disciplines, a structured curriculum consisting of didactics, operational rotations, and research projects was developed for those fellows interested in both pathology informatics and molecular pathology. Conclusions: The scope of molecular diagnostics is expanding dramatically as technology advances and our understanding of disease extends to the genetic level. Here, we highlight many of the informatics challenges facing molecular pathology today, and outline specific informatics principles necessary for the training of future molecular pathologists. PMID:24843823

  6. Aflatoxin plate kit. Performance Tested Method 081003.

    PubMed

    Trombley, Arthur; Fan, Titan; LaBudde, Robert

    2011-01-01

    The level of total aflatoxin contamination was analyzed in naturally contaminated and spiked samples of corn and peanut using the Aflatoxin Plate Kit. This kit is an enzyme-linked immunosorbent assay (ELISA) suitable for rapid testing of grains and peanuts. The assay was evaluated for ruggedness and linearity of the standard curve. The test kit results were then statistically evaluated for accuracy, precision, and correlation to a validated HPLC method (AOAC 994.08). The results were verified by an independent laboratory.

  7. Advantages of combined touch screen technology and text hyperlink for the pathology grossing manual: a simple approach to access instructive information in biohazardous environments.

    PubMed

    Qu, Zhenhong; Ghorbani, Rhonda P; Li, Hongyan; Hunter, Robert L; Hannah, Christina D

    2007-03-01

    Gross examination, encompassing description, dissection, and sampling, is a complex task and an essential component of surgical pathology. Because of the complexity of the task, standardized protocols to guide the gross examination often become a bulky manual that is difficult to use. This problem is further compounded by the high specimen volume and biohazardous nature of the task. As a result, such a manual is often underused, leading to errors that are potentially harmful and time consuming to correct-a common chronic problem affecting many pathology laboratories. To combat this problem, we have developed a simple method that incorporates complex text and graphic information of a typical procedure manual and yet allows easy access to any intended instructive information in the manual. The method uses the Object-Linking-and-Embedding function of Microsoft Word (Microsoft, Redmond, WA) to establish hyperlinks among different contents, and then it uses the touch screen technology to facilitate navigation through the manual on a computer screen installed at the cutting bench with no need for a physical keyboard or a mouse. It takes less than 4 seconds to reach any intended information in the manual by 3 to 4 touches on the screen. A 3-year follow-up study shows that this method has increased use of the manual and has improved the quality of gross examination. The method is simple and can be easily tailored to different formats of instructive information, allowing flexible organization, easy access, and quick navigation. Increased compliance to instructive information reduces errors at the grossing bench and improves work efficiency.

  8. Prehospital Cricothyrotomy Kits Used in Combat.

    PubMed

    Schauer, Steven G; April, Michael D; Cunningham, Cord W; Long, Adrianna N; Carter, Robert

    2017-01-01

    Surgical cricothyrotomy remains the only definitive airway management modality for the tactical setting recommended by Tactical Combat Casualty Care guidelines. Some units have fielded commercial cricothyrotomy kits to assist Combat Medics with surgical cricothyrotomy. To our knowledge, no previous publications report data on the use of these kits in combat settings. This series reports the the use of two kits in four patients in the prehospital combat setting. Using the Department of Defense Trauma Registry and the Prehospital Trauma Registry, we identified four cases of patients who underwent prehospital cricothyrotomy with the use of commercial kits. In the first two cases, a Medic successfully used a North American Rescue CricKit (NARCK) to obtain a surgical airway in a Servicemember with multiple amputations from an improvised explosive device explosion. In case 3, the Medic unsuccessfully used an H&H Medical kit to attempt placement of a surgical airway in a Servicemember shot in the head by small arms fire. A second attempt to place a surgical airway using a NARCK was successful. In case 4, a Soldier sustained a gunshot wound to the chest. A Medic described fluid in the airway precluding bag-valve-mask ventilation; the Medic attempted to place a surgical airway with the H&H kit without success. Four cases of prehospital surgical airway cannulation on the battlefield demonstrated three successful uses of prehospital cricothyrotomy kits. Further research should focus on determining which kits may be most useful in the combat setting. 2017.

  9. Genetic interaction between Kit and Scl.

    PubMed

    Lacombe, Julie; Krosl, Gorazd; Tremblay, Mathieu; Gerby, Bastien; Martin, Richard; Aplan, Peter D; Lemieux, Sebastien; Hoang, Trang

    2013-08-15

    SCL/TAL1, a tissue-specific transcription factor of the basic helix-loop-helix family, and c-Kit, a tyrosine kinase receptor, control hematopoietic stem cell survival and quiescence. Here we report that SCL levels are limiting for the clonal expansion of Kit⁺ multipotent and erythroid progenitors. In addition, increased SCL expression specifically enhances the sensitivity of these progenitors to steel factor (KIT ligand) without affecting interleukin-3 response, whereas a DNA-binding mutant antagonizes KIT function and induces apoptosis in progenitors. Furthermore, a twofold increase in SCL levels in mice bearing a hypomorphic Kit allele (W41/41) corrects their hematocrits and deficiencies in erythroid progenitor numbers. At the molecular level, we found that SCL and c-Kit signaling control a common gene expression signature, of which 19 genes are associated with apoptosis. Half of those were decreased in purified megakaryocyte/erythroid progenitors (MEPs) from W41/41 mice and rescued by the SCL transgene. We conclude that Scl operates downstream of Kit to support the survival of MEPs. Finally, higher SCL expression upregulates Kit in normal bone marrow cells and increases chimerism after bone marrow transplantation, indicating that Scl is also upstream of Kit. We conclude that Scl and Kit establish a positive feedback loop in multipotent and MEPs.

  10. [Initial management of advanced ovarian cancer: What radiological, pathological and surgical information are important for optimal therapeutic strategy?].

    PubMed

    Heudel, Pierre-Etienne; Selle, Frédéric; Morice, Philippe; Rouzier, Roman; Taieb, Sophie; Devouassoux-Shisheboran, Mojgan; Genestie, Catherine; Balleyguier, Corinne; Ray-Coquard, Isabelle

    2015-09-01

    Because the majority of patients present advanced disease at diagnosis, the management of epithelial ovarian cancer needs specialist multidisciplinary teamwork. Expertise in surgery, chemotherapy, imaging and histopathology is essential to achieve optimum outcomes. Computed tomography scans are routinely used to determine the extent of disease and to aid in surgical planning. The histologic classification is crucial to plan the best therapeutic strategy and to define the prognosis of disease. Pathological prognostic factors, such as degree of differentiation, FIGO-stage, and histological type have to be described. This report is fundamental to assessing prognosis and selection of appropriate treatment strategy. An adequate staging procedure is an extensive staging by an experienced gynecological oncologist, exploring the entire upper abdomen, and the pelvic and para-aortic lymph node regions to define the Peritoneal Cancer Index (PCI). The final assessment is the completeness of cytoreduction (CC) score, which is an assessment of residual disease after a maximal surgical effort. Initial management of advanced ovarian cancer is best provided by a specialist multidisciplinary team, including a radiologist, a pathologist, a gynecologic oncologist and a medical oncologist. Copyright © 2015 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  11. Oral pathology.

    PubMed

    Niemiec, Brook A

    2008-05-01

    Oral disease is exceedingly common in small animal patients. In addition, there is a very wide variety of pathologies that are encountered within the oral cavity. These conditions often cause significant pain and/or localized and systemic infection; however, the majority of these conditions have little to no obvious clinical signs. Therefore, diagnosis is not typically made until late in the disease course. Knowledge of these diseases will better equip the practitioner to effectively treat them. This article covers the more common forms of oral pathology in the dog and cat, excluding periodontal disease, which is covered in its own chapter. The various pathologies are presented in graphic form, and the etiology, clinical signs, recommended diagnostic tests, and treatment options are discussed. Pathologies that are covered include: persistent deciduous teeth, fractured teeth, intrinsically stained teeth, feline tooth resorption, caries, oral neoplasia, eosinophilic granuloma complex, lymphoplasmacytic gingivostomatitis, enamel hypoplasia, and "missing" teeth.

  12. Tumor stem cells (CD271, c-kit, SOX10) in Melanomas: prognostic and outcome implications.

    PubMed

    Mohamed, Amr; Gonzalez, Raul S; Lawson, Diane; Wang, Jason; Cohen, Cynthia

    2014-01-01

    Melanoma cells that express stem cell marker CD271 are shown to form tumors when transplanted into nude or immunodeficient mice. These tumors have a higher metastatic potential and worse prognosis than melanomas resulting from transplantation of CD271-negative cells. We studied stem cell markers (CD271, c-kit, SOX1O) in melanomas, correlating their presence with prognostic factors and outcome. A total of 82 melanomas in tissue microarrays were immunostained for CD271, c-kit, and SOX10. Results were correlated with clinicopathologic prognostic parameters (Breslow depth of invasion, Clark level, sentinel lymph node status, and pathologic stage) and outcome (recurrence, metastases, and death). Of the 82 melanomas, CD271 was expressed in 18 (21%), c-kit in 47 (57%), and SOX10 in all (100%). CD271 does show correlation with metastases (P=0.05). c-kit is associated with favorable prognostic parameters [Breslow depth (P<0.001) and pathologic stage (P=0.02)] and with improved outcome [recurrence (P=0.03) and metastases (P=0.004)]. Although SOX10 is a good diagnostic marker, it cannot be used for prognosis because it is expressed in all the melanomas studied. In conclusion, CD271 expression in melanomas is associated with increased frequency of metastases, and c-kit immunoreactivity is associated with favorable prognostic parameters and improved outcome.

  13. Marshall Space Flight Center Telescience Resource Kit

    NASA Technical Reports Server (NTRS)

    Wade, Gina

    2016-01-01

    Telescience Resource Kit (TReK) is a suite of software applications that can be used to monitor and control assets in space or on the ground. The Telescience Resource Kit was originally developed for the International Space Station program. Since then it has been used to support a variety of NASA programs and projects including the WB-57 Ascent Vehicle Experiment (WAVE) project, the Fast Affordable Science and Technology Satellite (FASTSAT) project, and the Constellation Program. The Payloads Operations Center (POC), also known as the Payload Operations Integration Center (POIC), provides the capability for payload users to operate their payloads at their home sites. In this environment, TReK provides local ground support system services and an interface to utilize remote services provided by the POC. TReK provides ground system services for local and remote payload user sites including International Partner sites, Telescience Support Centers, and U.S. Investigator sites in over 40 locations worldwide. General Capabilities: Support for various data interfaces such as User Datagram Protocol, Transmission Control Protocol, and Serial interfaces. Data Services - retrieve, process, record, playback, forward, and display data (ground based data or telemetry data). Command - create, modify, send, and track commands. Command Management - Configure one TReK system to serve as a command server/filter for other TReK systems. Database - databases are used to store telemetry and command definition information. Application Programming Interface (API) - ANSI C interface compatible with commercial products such as Visual C++, Visual Basic, LabVIEW, Borland C++, etc. The TReK API provides a bridge for users to develop software to access and extend TReK services. Environments - development, test, simulations, training, and flight. Includes standalone training simulators.

  14. The Project Manager's Tool Kit

    NASA Technical Reports Server (NTRS)

    Cameron, W. Scott

    2003-01-01

    Project managers are rarely described as being funny. Moreover, a good sense of humor rarely seems to be one of the deciding factors in choosing someone to be a project manager, or something that pops up as a major discussion point at an annual performance review. Perhaps this is because people think you aren't serious about your work if you laugh. I disagree with this assessment, but that's not really my point. As I talk to people either pursuing a career in project management, or broadening their assignment to include project management, I encourage them to consider what tools they need to be successful. I suggest that they consider any strength they have to be part of their Project Management (PM) Tool Kit, and being funny could be one of the tools they need.

  15. Building Use Policies. SPEC Kit 144.

    ERIC Educational Resources Information Center

    Coyle, Patrick

    This Systems and Procedures Exchange Center (SPEC) flyer/kit addresses some of the needs of Association of Research Libraries (ARL) members regarding library building use and the aesthetics and well-being of the materials and people in the building. The kit draws upon documents gathered as part of a 1986 Quick-SPEC survey that dealt with food and…

  16. Special tool kit aids heavily garmented workers

    NASA Technical Reports Server (NTRS)

    Holmes, A. E.

    1966-01-01

    Triangular aluminum tool kit, filled with polyurethane is constructed to receive various tools and hold them in a snug but quick-release fit as an aid to heavily gloved workers. The kit is designed to allow mounting within easily accessable reach and to provide protection of the tools during storage.

  17. Anatomy of a Minicourse. Audiovisual Kit.

    ERIC Educational Resources Information Center

    Meyer, Rex

    This kit explains the use of minicourses at Macquarie University in New South Wales, Australia, which were designed for the inservice training of teachers. The kit contains the script of the audio commentary, a cassette tape, color slides, and a booklet entitled "Anatomy of the Minicourse." The tape briefly describes the minicourses in general and…

  18. CARE Kit: Combining Activities with Real Experiences.

    ERIC Educational Resources Information Center

    Eastern Illinois Univ., Charleston.

    Materials presented in this kit form a package containing eighty-six vocational development oriented activities designed primarily for individuals and small groups of underachieving junior high or high school students and is intended to supplement regular classroom activities. Included in the kit are the following: (1) a teacher's guide containing…

  19. Habitats NatureScope[R] Kit.

    ERIC Educational Resources Information Center

    Emerson, Eva

    This kit introduces the basic concepts of habitat through challenging and engaging interdisciplinary, hands-on activities. The material is designed for K-8 educators working in traditional and non- traditional classrooms with the goals of increasing awareness of the ways habitats work and why they are important. This kit consists of four…

  20. Blood collection kit for Space Lab 1

    NASA Image and Video Library

    1981-02-02

    S81-26158 (Feb 1981) --- A close-up view of a training version of a STS-40/SLS-1 blood kit. Blood samples from crewmembers are critical to a number of Space Life Sciences-1 (SLS-1) investigations. One day's collection equipment, color coded for each crewmember, is neatly organized in the kit.

  1. Features of the Java commodity grid kit.

    SciTech Connect

    von Laszewski, G.; Gawor, J.; Lane, P.; Rehn, N.; Russell, M.; Mathematics and Computer Science

    2002-11-01

    In this paper we report on the features of the Java Commodity Grid Kit (Java CoG Kit). The Java CoG Kit provides middleware for accessing Grid functionality from the Java framework. Java CoG Kit middleware is general enough to design a variety of advanced Grid applications with quite different user requirements. Access to the Grid is established via Globus Toolkit protocols, allowing the Java CoG Kit to also communicate with the services distributed as part of the C Globus Toolkit reference implementation. Thus, the Java CoG Kit provides Grid developers with the ability to utilize the Grid, as well as numerous additional libraries and frameworks developed by the Java community to enable network, Internet, enterprise and peer-to-peer computing. A variety of projects have successfully used the client libraries of the Java CoG Kit to access Grids driven by the C Globus Toolkit software. In this paper we also report on the efforts to develop serverside Java CoG Kit components. As part of this research we have implemented a prototype pure Java resource management system that enables one to run Grid jobs on platforms on which a Java virtual machine is supported, including Windows NT machines.

  2. A Prototype Grammar Kit in Prolog.

    ERIC Educational Resources Information Center

    Kahn, Kenneth M.

    1984-01-01

    Presents a prototype of a computerized grammar kit written in PROLOG and designed for children interested in exploring language. PROLOG's advantages for building parsers, generators, translators, and question-answering systems are discussed, and a scenario of a child working on a grammar project using the kit and implementation issues are…

  3. Affirmative Action Programs. SPEC Kit 67.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Systems and Procedures Exchange Center (SPEC) kit on affirmative action programs, which replaces an earlier SPEC kit on affirmative action, contains planning documents from Association of Research Libraries (ARL) member institutions and policy statements on affirmative action and equal employment opportunity from several universities. The kit…

  4. Culture Kits for the Elementary Classroom.

    ERIC Educational Resources Information Center

    Hickey, M. Gail

    1997-01-01

    Outlines an instructional unit where students construct culture kits illustrating a specific culture. Culture kits are constructed out of realia and other material including maps, travel brochures, photographs, newspapers, souvenirs, and other items. Discusses collecting these items and possible multicultural applications. (MJP)

  5. Image management in pathology.

    PubMed

    Weinberg, D S; Doolittle, M

    1996-04-01

    Much of the diagnostic work in pathology, especially surgical pathology and cytology, involves the interpretation of images. Recent advances in digital imaging technologies and telecommunications will allow pathologists to use image-based information in ways that are not possible using conventional glass slides alone. We are entering an age in which image-based information can be more easily and widely shared, both locally and globally. In this article, some of the digital technologies that can allow pathologists to make more effective use of diagnostic images will be discussed.

  6. Complexity and forensic pathology.

    PubMed

    Jones, Richard Martin

    2015-12-01

    It has become increasingly apparent that nonlinearity and complexity are the norm in human physiological systems, the relevance of which is informing an enhanced understanding of basic pathological processes such as inflammation, the host response to severe trauma, and critical illness. This article will explore how an understanding of nonlinear systems and complexity might inform the study of the pathophysiology of deaths of medicolegal interest, and how 'complexity thinking' might usefully be incorporated into modern forensic medicine and forensic pathology research, education and practice.

  7. Inguinoscrotal pathology

    PubMed Central

    Guerra, Luis; Leonard, Michael

    2017-01-01

    Infants, children, and adolescents with inguinoscrotal pathology comprise a significant proportion of emergency department and outpatient visits. Visits to the emergency department primarily comprise individuals presenting with scrotal pain due to testicular torsion or torsion of the testicular appendages. At such time, immediate urological consultation is sought. Outpatient visits comprise those individuals with undescended testes, hydroceles, and varicoceles. Rare, but important problems, such as pediatric testicular tumours, may also present in the office setting. Many of these outpatient visits are to primary care physicians, who should have an appreciation of the timing and need for referral. The purpose of this review is to familiarize the general urologist and primary care physician with these varied pathologies and give insight into their assessment and management. Some of these same conditions are seen in adult patients, but there are some significant differences in their management in the pediatric group. In addition, the utility of imaging studies, such as ultrasound, are discussed within each pathological entity. It is hoped that this overview will assist our general urology and primary care colleagues in patient management for diverse inguinoscrotal pathologies. PMID:28265317

  8. 100G Deployment@(DE-KIT)

    NASA Astrophysics Data System (ADS)

    Hoeft, Bruno; Petzold, Andreas

    2015-12-01

    The Steinbuch Centre for Computing (SCC) at Karlsruhe Institute of Technology (KIT) has been involved fairly early in 100GE network technology. Initiated by DFN1 (the German NREN), a first 100GE wide area network testbed over a distance of approx. 450 km was deployed between the national research organizations KIT and FZ-Jülich in 2010. Three years later in 2013. KIT joined the Caltech SuperComputing 2013 (SC132) 100GE "show floor" initiative using the transatlantic ANA-100GE link to transfer LHC data from a storage at DE-KIT (GridKa) in Europe to hard disks at the show floor of SC13 in Denver (USA). The network infrastructure of KIT as well as of the German Tier-1 installation DE-KIT (GridKa). however. is still based on 10Gbps. As highlighted in the contribution "Status and Trends in Networking at LHC Tier1 Facilities" to CHEP 2012. proactive investment is required at the Tier-1 sites. Bandwidth requirements will grow beyond current capacity and the required upgrades are expected in 2015. In close cooperation with DFN. KIT drives the upgrade from 10GE to 100GE. The process is divided into several phases. due to upgrade costs and differing requirements in different parts of the network infrastructure. The requirements of the different phases as well as the planned topology will be described. Some of the obstacles we discovered during the deployment will be discussed and solutions or workarounds presented.

  9. Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information

    PubMed Central

    2013-01-01

    Background Virtual microscopy includes digitisation of histology slides and the use of computer technologies for complex investigation of diseases such as cancer. However, automated image analysis, or website publishing of such digital images, is hampered by their large file sizes. Results We have developed two Java based open source tools: Snapshot Creator and NDPI-Splitter. Snapshot Creator converts a portion of a large digital slide into a desired quality JPEG image. The image is linked to the patient’s clinical and treatment information in a customised open source cancer data management software (Caisis) in use at the Australian Breast Cancer Tissue Bank (ABCTB) and then published on the ABCTB website (http://www.abctb.org.au) using Deep Zoom open source technology. Using the ABCTB online search engine, digital images can be searched by defining various criteria such as cancer type, or biomarkers expressed. NDPI-Splitter splits a large image file into smaller sections of TIFF images so that they can be easily analysed by image analysis software such as Metamorph or Matlab. NDPI-Splitter also has the capacity to filter out empty images. Conclusions Snapshot Creator and NDPI-Splitter are novel open source Java tools. They convert digital slides into files of smaller size for further processing. In conjunction with other open source tools such as Deep Zoom and Caisis, this suite of tools is used for the management and archiving of digital microscopy images, enabling digitised images to be explored and zoomed online. Our online image repository also has the capacity to be used as a teaching resource. These tools also enable large files to be sectioned for image analysis. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5330903258483934 PMID:23402499

  10. Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information.

    PubMed

    Khushi, Matloob; Edwards, Georgina; de Marcos, Diego Alonso; Carpenter, Jane E; Graham, J Dinny; Clarke, Christine L

    2013-02-12

    Virtual microscopy includes digitisation of histology slides and the use of computer technologies for complex investigation of diseases such as cancer. However, automated image analysis, or website publishing of such digital images, is hampered by their large file sizes. We have developed two Java based open source tools: Snapshot Creator and NDPI-Splitter. Snapshot Creator converts a portion of a large digital slide into a desired quality JPEG image. The image is linked to the patient's clinical and treatment information in a customised open source cancer data management software (Caisis) in use at the Australian Breast Cancer Tissue Bank (ABCTB) and then published on the ABCTB website (http://www.abctb.org.au) using Deep Zoom open source technology. Using the ABCTB online search engine, digital images can be searched by defining various criteria such as cancer type, or biomarkers expressed. NDPI-Splitter splits a large image file into smaller sections of TIFF images so that they can be easily analysed by image analysis software such as Metamorph or Matlab. NDPI-Splitter also has the capacity to filter out empty images. Snapshot Creator and NDPI-Splitter are novel open source Java tools. They convert digital slides into files of smaller size for further processing. In conjunction with other open source tools such as Deep Zoom and Caisis, this suite of tools is used for the management and archiving of digital microscopy images, enabling digitised images to be explored and zoomed online. Our online image repository also has the capacity to be used as a teaching resource. These tools also enable large files to be sectioned for image analysis. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5330903258483934.

  11. A miniaturized kit for ozone biomonitoring

    SciTech Connect

    Lorenzini, G.

    1994-07-01

    A new miniaturized kit based on very young supersensitive tobacco Bel-W3 plantlets, which can be easily used to detect phytotoxic levels of ozone in ambient air in large scale surveys, is described. It has been developed in laboratory as well as field studies. The optimal sampling time is 5-7 d. The advantages of the kit are its user-friendliness, low cost, and reliability. The kit may be integrated by a passive sampling tube set and may be also proposed for educational programs. 6 refs., 2 figs.

  12. The SCRAM tool-kit

    NASA Technical Reports Server (NTRS)

    Tamir, David; Flanigan, Lee A.; Weeks, Jack L.; Siewert, Thomas A.; Kimbrough, Andrew G.; Mcclure, Sidney R.

    1994-01-01

    This paper proposes a new series of on-orbit capabilities to support the near-term Hubble Space Telescope, Extended Duration Orbiter, Long Duration Orbiter, Space Station Freedom, other orbital platforms, and even the future manned Lunar/Mars missions. These proposed capabilities form a toolkit termed Space Construction, Repair, and Maintenance (SCRAM). SCRAM addresses both intra-Vehicular Activity (IVA) and Extra-Vehicular Activity (EVA) needs. SCRAM provides a variety of tools which enable welding, brazing, cutting, coating, heating, and cleaning, as well as corresponding nondestructive examination. Near-term IVA-SCRAM applications include repair and modification to fluid lines, structure, and laboratory equipment inside a shirt-sleeve environment (i.e. inside Spacelab or Space Station). Near-term EVA-SCRAM applications include construction of fluid lines and structural members, repair of punctures by orbital debris, refurbishment of surfaces eroded by contaminants. The SCRAM tool-kit also promises future EVA applications involving mass production tasks automated by robotics and artificial intelligence, for construction of large truss, aerobrake, and nuclear reactor shadow shields structures. The leading candidate tool processes for SCRAM, currently undergoing research and development, include Electron Beam, Gas Tungsten Arc, Plasma Arc, and Laser Beam. A series of strategic space flight experiments would make SCRAM available to help conquer the space frontier.

  13. Telescience Resource Kit Software Lifecycle

    NASA Technical Reports Server (NTRS)

    Griner, Carolyn S.; Schneider, Michelle

    1998-01-01

    The challenge of a global operations capability led to the Telescience Resource Kit (TReK) project, an in-house software development project of the Mission Operations Laboratory (MOL) at NASA's Marshall Space Flight Center (MSFC). The TReK system is being developed as an inexpensive comprehensive personal computer- (PC-) based ground support system that can be used by payload users from their home sites to interact with their payloads on board the International Space Station (ISS). The TReK project is currently using a combination of the spiral lifecycle model and the incremental lifecycle model. As with any software development project, there are four activities that can be very time consuming: Software design and development, project documentation, testing, and umbrella activities, such as quality assurance and configuration management. In order to produce a quality product, it is critical that each of these activities receive the appropriate amount of attention. For TReK, the challenge was to lay out a lifecycle and project plan that provides full support for these activities, is flexible, provides a way to deal with changing risks, can accommodate unknowns, and can respond to changes in the environment quickly. This paper will provide an overview of the TReK lifecycle, a description of the project's environment, and a general overview of project activities.

  14. Direct qPCR quantification using the Quantifiler(®) Trio DNA quantification kit.

    PubMed

    Liu, Jason Yingjie

    2014-11-01

    The effectiveness of a direct quantification assay is essential to the adoption of the combined direct quantification/direct STR workflow. In this paper, the feasibility of using the Quantifiler(®) Trio DNA quantification kit for the direct quantification of forensic casework samples was investigated. Both low-level touch DNA samples and blood samples were collected on PE swabs and quantified directly. The increased sensitivity of the Quantifiler(®) Trio kit enabled the detection of less than 10pg of DNA in unprocessed touch samples and also minimizes the stochastic effect experienced by different targets in the same sample. The DNA quantity information obtained from a direct quantification assay using the Quantifiler(®) Trio kit can also be used to accurately estimate the optimal input DNA quantity for a direct STR amplification reaction. The correlation between the direct quantification results (Quantifiler(®) Trio kit) and the direct STR results (GlobalFiler™ PCR amplification kit(*)) for low-level touch DNA samples indicates that direct quantification using the Quantifiler(®) Trio DNA quantification kit is more reliable than the Quantifiler(®) Duo DNA quantification kit for predicting the STR results of unprocessed touch DNA samples containing less than 10pg of DNA.

  15. Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas.

    PubMed

    Murakami, A; Mori, T; Sakai, H; Murakami, M; Yanai, T; Hoshino, Y; Maruo, K

    2011-09-01

    KIT, a transmembrane receptor tyrosine kinase, is one of the specific targets for anti-cancer therapy. In humans, its expression and mutations have been identified in malignant melanomas and therapies using molecular-targeted agents have been promising in these tumours. As human malignant melanoma, canine malignant melanoma is a fatal disease with metastases and the poor response has been observed with all standard protocols. In our study, KIT expression and exon 11 mutations in dogs with histologically confirmed malignant oral melanomas were evaluated. Although 20 of 39 cases were positive for KIT protein, there was no significant difference between KIT expression and overall survival. Moreover, polymerase chain reaction amplification and sequencing of KIT exon 11 in 17 samples did not detect any mutations and proved disappointing. For several reasons, however, KIT expression and mutations of various exons including exon 11 should be investigated in more cases.

  16. Pathologists' Computer-Assisted Diagnosis: A Mock-up of a Prototype Information System to Facilitate Automation of Pathology Sign-out.

    PubMed

    Farahani, Navid; Liu, Zheng; Jutt, Dylan; Fine, Jeffrey L

    2017-10-01

    - Pathologists' computer-assisted diagnosis (pCAD) is a proposed framework for alleviating challenges through the automation of their routine sign-out work. Currently, hypothetical pCAD is based on a triad of advanced image analysis, deep integration with heterogeneous information systems, and a concrete understanding of traditional pathology workflow. Prototyping is an established method for designing complex new computer systems such as pCAD. - To describe, in detail, a prototype of pCAD for the sign-out of a breast cancer specimen. - Deidentified glass slides and data from breast cancer specimens were used. Slides were digitized into whole-slide images with an Aperio ScanScope XT, and screen captures were created by using vendor-provided software. The advanced workflow prototype was constructed by using PowerPoint software. - We modeled an interactive, computer-assisted workflow: pCAD previews whole-slide images in the context of integrated, disparate data and predefined diagnostic tasks and subtasks. Relevant regions of interest (ROIs) would be automatically identified and triaged by the computer. A pathologist's sign-out work would consist of an interactive review of important ROIs, driven by required diagnostic tasks. The interactive session would generate a pathology report automatically. - Using animations and real ROIs, the pCAD prototype demonstrates the hypothetical sign-out in a stepwise fashion, illustrating various interactions and explaining how steps can be automated. The file is publicly available and should be widely compatible. This mock-up is intended to spur discussion and to help usher in the next era of digitization for pathologists by providing desperately needed and long-awaited automation.

  17. Village Green Project and Air Sensor Kits

    EPA Science Inventory

    This is a presentation for the OAQPS Teachers Workshop. Will provide a background overview on the Village Green Project and our air sensor kit for outreach, then have the teachers try putting it together.

  18. Kits for Less Than Fifty Cents

    ERIC Educational Resources Information Center

    Abruscato, Joseph; Varney, Douglas

    1975-01-01

    Describes the use of teacher-made discovery kits for use in science activities. Suggestions are provided to help teachers scrounge surplus materials from stores, small manufacturers, doctors and other potential suppliers of free materials. (PEB)

  19. Development of a forensic evidence protection kit

    NASA Astrophysics Data System (ADS)

    Acton, Brian; Kelly, Roy

    1999-02-01

    A kit has been developed for the preservation of vital forensic evidence on a suspect following a serious assault, murder or other offense where contamination may occur. This also includes the handling of firearms, explosives and/or drugs.

  20. Village Green Project and Air Sensor Kits

    EPA Science Inventory

    This is a presentation for the OAQPS Teachers Workshop. Will provide a background overview on the Village Green Project and our air sensor kit for outreach, then have the teachers try putting it together.

  1. Expression of c-kit and Slug correlates with invasion and metastasis of salivary adenoid cystic carcinoma.

    PubMed

    Tang, Yaling; Liang, Xinhua; Zheng, Min; Zhu, Zhiyu; Zhu, Guiquan; Yang, Jing; Chen, Yu

    2010-04-01

    The overexpression of c-kit seems to be frequent and specific in salivary adenoid cystic carcinoma (ACC), however, there is little information on correlation between c-kit expression and the invasion and metastasis. Recently, the data showed that Slug, a transcription factor of epithelial-mesenchymal transitions (EMT), is a molecular target that contributes to the biological specificity of c-kit signaling pathway. In this study, the expression of c-kit and Slug was evaluated in two ACC cell lines and 121 patients with ACC. The results of real-time RT-PCR and Western blot showed that ACC-2 and ACC-M cell lines expressed c-kit and Slug mRNA and protein. The immunohistochemical assay in patients demonstrated that positive expression of c-kit and Slug was observed in 108/121 (89.26%) and 87/121 (71.90%) of cases, respectively, and that c-kit and Slug expression was significantly associated with tumor site, TNM stage, histological pattern, perineural invasion, local regional recurrence and distant metastasis of patients with ACC (P<0.05). Furthermore, there was a significant association between the positive expression of c-kit and that of Slug (P=0.046). These findings indicated that c-kit/Slug pathway might participate in the invasion and metastasis of salivary ACC.

  2. The Cellie Coping Kit for Sickle Cell Disease: Initial acceptability and feasibility

    PubMed Central

    Marsac, Meghan L.; Klingbeil, Olivia G.; Hildenbrand, Aimee K.; Alderfer, Melissa A.; Kassam-Adams, Nancy; Smith-Whitley, Kim; Barakat, Lamia P.

    2014-01-01

    Sickle Cell Disease (SCD) and its treatment can place physical and psychosocial strain on children and their families, underlining the need for behavioral and emotional support. Much of SCD is often managed at home, which may prevent children from obtaining supportive services from medical and psychosocial teams. Children with SCD report a restricted number of coping strategies specific to managing SCD and may benefit from education on adaptive coping. To address this unmet need, a coping tool for children with cancer (Cellie Cancer Coping Kit) was adapted for children with SCD. The Cellie Coping Kit for SCD (Cellie Coping Kit) includes a stuffed “Cellie” toy, coping cards for children, and a book for caregivers. This study sought to assess the acceptability and feasibility of an intervention utilizing the Cellie Coping Kit. Fifteen children with SCD (ages 6-14) and their caregivers participated in a baseline assessment including semi-structured interviews to examine SCD-related stressors and coping strategies. Next, families received a brief introduction to the Cellie Coping Kit and were provided with a kit to use independently over the next four weeks before completing a follow-up assessment. Results indicated strong intervention acceptability overall. While families reported using and learning information and skills from the Cellie Coping Kit, several challenges were identified (e.g., child's living situation, busy schedules). The Cellie Coping Kit is a promising tool to support children with SCD and their families. Future research should examine whether use of the Cellie Coping Kit impacts behavioral change and improved health outcomes. PMID:25664228

  3. LEM-CF Premixed Tool Kit

    SciTech Connect

    2015-01-19

    The purpose of LEM-CF Premixed Tool Kit is to process premixed flame simulation data from the LEM-CF solver (https://fileshare.craft-tech.com/clusters/view/lem-cf) into a large-eddy simulation (LES) subgrid model database. These databases may be used with a user-defined-function (UDF) that is included in the Tool Kit. The subgrid model UDF may be used with the ANSYS FLUENT flow solver or other commercial flow solvers.

  4. The Topology ToolKit.

    PubMed

    Tierny, Julien; Favelier, Guillaume; Levine, Joshua A; Gueunet, Charles; Michaux, Michael

    2017-08-29

    This system paper presents the Topology ToolKit (TTK), a software platform designed for the topological analysis of scalar data in scientific visualization. While topological data analysis has gained in popularity over the last two decades, it has not yet been widely adopted as a standard data analysis tool for end users or developers. TTK aims at addressing this problem by providing a unified, generic, efficient, and robust implementation of key algorithms for the topological analysis of scalar data, including: critical points, integral lines, persistence diagrams, persistence curves, merge trees, contour trees, Morse-Smale complexes, fiber surfaces, continuous scatterplots, Jacobi sets, Reeb spaces, and more. TTK is easily accessible to end users due to a tight integration with ParaView. It is also easily accessible to developers through a variety of bindings (Python, VTK/C++) for fast prototyping or through direct, dependency-free, C++, to ease integration into pre-existing complex systems. While developing TTK, we faced several algorithmic and software engineering challenges, which we document in this paper. In particular, we present an algorithm for the construction of a discrete gradient that complies to the critical points extracted in the piecewise-linear setting. This algorithm guarantees a combinatorial consistency across the topological abstractions supported by TTK, and importantly, a unified implementation of topological data simplification for multi-scale exploration and analysis. We also present a cached triangulation data structure, that supports time efficient and generic traversals, which self-adjusts its memory usage on demand for input simplicial meshes and which implicitly emulates a triangulation for regular grids with no memory overhead. Finally, we describe an original software architecture, which guarantees memory efficient and direct accesses to TTK features, while still allowing for researchers powerful and easy bindings and extensions

  5. C-KIT signaling in cancer treatment.

    PubMed

    Stankov, Karmen; Popovic, Stevan; Mikov, Momir

    2014-01-01

    Tumor progression is strongly associated with the activity of receptor tyrosine kinases (RTKs) and their intracellular signal transduction pathways, which regulate several cell functions including proliferation, apoptosis, motility, adhesion and angiogenesis. Detailed structural and functional studies of RTKs, including the stem cell factor receptor c-KIT, revealed the complexity of these receptor systems and contributed to development of targeted clinical approaches with relevance in both prognosis and therapy. C-KIT signaling network has been the subject of intense research and pharmaceutical strategies to identify novel target-based approaches for cancer treatment. Evidence that c-KIT signaling promotes cell proliferation and survival, along with the frequency in which this pathway is aberrantly activated in cancer, support the current efforts to identify approaches for its efficient inhibition. C-KIT mutations are associatied with several human malignancies, such as gastrointestinal stromal tumors, acute myeloid leukemia, mast cell leukemia, and melanoma. Novel therapies are developed that target some of the identified genetic defects. It is therefore anticipated that newly-identified genetic markers will acquire a predictive value, that is, the ability to predict differential efficacy of a therapy. This review describes the evolving understanding of c-KIT/SCF axis and their downstream signaling in cancer, and the strategies for c-KIT-directed targeted cancer therapy.

  6. Orbital Maneuvering Vehicle (OMV) remote servicing kit

    NASA Technical Reports Server (NTRS)

    Brown, Norman S.

    1988-01-01

    With the design and development of the Orbital Maneuvering Vehicle (OMV) progressing toward an early 1990 initial operating capability (IOC), a new era in remote space operations will evolve. The logical progression to OMV front end kits would make available in situ satellite servicing, repair, and consummables resupply to the satellite community. Several conceptual design study efforts are defining representative kits (propellant tanks, debris recovery, module servicers); additional focus must also be placed on an efficient combination module servicer and consummables resupply kit. A remote servicer kit of this type would be designed to perform many of the early maintenance/resupply tasks in both nominal and high inclination orbits. The kit would have the capability to exchange Orbital Replacement Units (ORUs), exchange propellant tanks, and/or connect fluid transfer umbilicals. Necessary transportation system functions/support could be provided by interfaces with the OMV, Shuttle (STS), or Expendable Launch Vehicle (ELV). Specific remote servicer kit designs, as well as ground and flight demonstrations of servicer technology are necessary to prepare for the potential overwhelming need. Ground test plans should adhere to the component/system/breadboard test philosophy to assure maximum capability of one-g testing. The flight demonstration(s) would most likely be a short duration, Shuttle-bay experiment to validate servicer components requiring a micro-g environment.

  7. Orbital Maneuvering Vehicle (OMV) remote servicing kit

    NASA Technical Reports Server (NTRS)

    Brown, Norman S.

    1988-01-01

    With the design and development of the Orbital Maneuvering Vehicle (OMV) progressing toward an early 1990 initial operating capability (IOC), a new era in remote space operations will evolve. The logical progression to OMV front end kits would make available in situ satellite servicing, repair, and consummables resupply to the satellite community. Several conceptual design study efforts are defining representative kits (propellant tanks, debris recovery, module servicers); additional focus must also be placed on an efficient combination module servicer and consummables resupply kit. A remote servicer kit of this type would be designed to perform many of the early maintenance/resupply tasks in both nominal and high inclination orbits. The kit would have the capability to exchange Orbital Replacement Units (ORUs), exchange propellant tanks, and/or connect fluid transfer umbilicals. Necessary transportation system functions/support could be provided by interfaces with the OMV, Shuttle (STS), or Expendable Launch Vehicle (ELV). Specific remote servicer kit designs, as well as ground and flight demonstrations of servicer technology are necessary to prepare for the potential overwhelming need. Ground test plans should adhere to the component/system/breadboard test philosophy to assure maximum capability of one-g testing. The flight demonstration(s) would most likely be a short duration, Shuttle-bay experiment to validate servicer components requiring a micro-g environment.

  8. Niche anchorage and signaling through membrane-bound Kit-ligand/c-kit receptor are kinase independent and imatinib insensitive.

    PubMed

    Tabone-Eglinger, Séverine; Calderin-Sollet, Zuleika; Pinon, Perrine; Aebischer, Nicole; Wehrle-Haller, Monique; Jacquier, Marie-Claude; Boettiger, David; Wehrle-Haller, Bernhard

    2014-10-01

    Kit ligand (KitL) and its tyrosine kinase receptor c-kit are critical for germ cells, melanocytes, mastocytes, and hematopoietic stem cells. Alternative splicing of KitL generates membrane-bound KitL (mb-KitL) or soluble KitL, providing survival or cell migration, respectively. Here we analyzed whether c-kit can function both as an adhesion and signaling receptor to mb-KitL presented by the environmental niche. At contacts between fibroblasts and MC/9 mast cells, mb-KitL, and c-kit formed ligand/receptor clusters that formed stable complexes, which resisted dissociation by c-kit blocking mAbs and provided cell anchorage under physiological shear stresses. Clusters recruited tyrosine-phosphorylated proteins and induced spatially restricted F-actin polymerization. Mutational analysis of c-kit demonstrated kinase-independent mb-KitL/c-kit clustering, anchorage, F-actin polymerization, and Tyr567-dependent cluster phosphorylation. Kinase inhibition of c-kit by imatinib reduced cluster coalescence, but allowed cluster phosphorylation and F-actin polymerization, which required PI3K recruitment and a newly identified juxtamembrane residue. Synergies between integrin and c-kit-mediated spreading and adhesion of MC/9 cells were studied in vitro on immobilized-KitL/fibronectin surfaces. While c-kit blocking antibodies prevented spreading, imatinib blocked spreading induced by soluble- but not immobilized KitL. Thus, "mechanical" activation of c-kit provides signaling, niche-anchorage, and synergies with integrin-mediated adhesion, which is independent of kinase function and resistant to c-kit kinase inhibitors.-

  9. Resveratrol Improves Cell Cycle Arrest in Chronic Prostatitis Rats, by C-kit/SCF Suppression.

    PubMed

    He, Yi; Zeng, Huizhi; Yu, Yang; Zhang, Jiashu; Zeng, Xiaona; Gong, Fengtao; Liu, Qi; Yang, Bo

    2017-08-01

    Chronic prostatitis (CP) with complex pathogenesis is difficult for treatment. c-kit has been associated with the control of cell proliferation of prostate cells. This study aims to evaluate the role of resveratrol, an activator of Sirt1, in regulating the expression of c-kit in CP and investigate the consequent effects on cell cycle. Rat model of CP was established through subcutaneous injections of diphtheria-pertussis-tetanus vaccine and subsequently treated with resveratrol. Hematoxylin and eosin staining was performed to identify the histopathological changes in prostates. Western blotting and immunohistochemical staining examined the expression level of c-kit, stem cell factor (SCF), Sirt1, and cell cycle-associated proteins. The model group exhibited severe diffuse chronic inflammation, characterized by leukocyte infiltration and papillary frond protrusion into the gland cavities, and a notable increase in prostatic epithelial height. Gland lumen diameter was also significantly smaller; the activity of c-kit/SCF in the CP rats was increased significantly compared to the control group. Meanwhile, the cell cycle proteins are dysregulated significantly in CP rats. Resveratrol treatment significantly improved these factors by Sirt1 activation. Dysregulation of cell cycle was involved in the pathological processes of CP, which was improved after resveratrol treatment by the downregulation of c-kit/SCF by activating Sirt1.

  10. Generation of Functional Blood Vessels from a Single c-kit+ Adult Vascular Endothelial Stem Cell

    PubMed Central

    Fang, Shentong; Wei, Jing; Pentinmikko, Nalle; Leinonen, Hannele; Salven, Petri

    2012-01-01

    In adults, the growth of blood vessels, a process known as angiogenesis, is essential for organ growth and repair. In many disorders including cancer, angiogenesis becomes excessive. The cellular origin of new vascular endothelial cells (ECs) during blood vessel growth in angiogenic situations has remained unknown. Here, we provide evidence for adult vascular endothelial stem cells (VESCs) that reside in the blood vessel wall endothelium. VESCs constitute a small subpopulation within CD117+ (c-kit+) ECs capable of undergoing clonal expansion while other ECs have a very limited proliferative capacity. Isolated VESCs can produce tens of millions of endothelial daughter cells in vitro. A single transplanted c-kit-expressing VESC by the phenotype lin−CD31+CD105+Sca1+CD117+ can generate in vivo functional blood vessels that connect to host circulation. VESCs also have long-term self-renewal capacity, a defining functional property of adult stem cells. To provide functional verification on the role of c-kit in VESCs, we show that a genetic deficit in endothelial c-kit expression markedly decreases total colony-forming VESCs. In vivo, c-kit expression deficit resulted in impaired EC proliferation and angiogenesis and retardation of tumor growth. Isolated VESCs could be used in cell-based therapies for cardiovascular repair to restore tissue vascularization after ischemic events. VESCs also provide a novel cellular target to block pathological angiogenesis and cancer growth. PMID:23091420

  11. 21 CFR 868.1100 - Arterial blood sampling kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Arterial blood sampling kit. 868.1100 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood...

  12. 21 CFR 868.1100 - Arterial blood sampling kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Arterial blood sampling kit. 868.1100 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood...

  13. 21 CFR 868.1100 - Arterial blood sampling kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Arterial blood sampling kit. 868.1100 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood...

  14. 21 CFR 868.1100 - Arterial blood sampling kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Arterial blood sampling kit. 868.1100 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood...

  15. 21 CFR 870.1350 - Catheter balloon repair kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Catheter balloon repair kit. 870.1350 Section 870... repair kit. (a) Identification. A catheter balloon repair kit is a device used to repair or replace the balloon of a balloon catheter. The kit contains the materials, such as glue and balloons, necessary...

  16. 49 CFR 173.165 - Polyester resin kits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Polyester resin kits. 173.165 Section 173.165... Polyester resin kits. (a) Polyester resin kits consisting of a base material component (Class 3, Packing..., according to the criteria for Class 3, applied to the base material. Additionally, polyester resin kits...

  17. 49 CFR 173.165 - Polyester resin kits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Polyester resin kits. 173.165 Section 173.165... Polyester resin kits. (a) Except for transportation by aircraft, polyester resin kits consisting of a base... resin kits consisting of a base material component (Class 3, Packing Group II or III) and an...

  18. 21 CFR 870.1350 - Catheter balloon repair kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Catheter balloon repair kit. 870.1350 Section 870... repair kit. (a) Identification. A catheter balloon repair kit is a device used to repair or replace the balloon of a balloon catheter. The kit contains the materials, such as glue and balloons, necessary...

  19. 21 CFR 870.1350 - Catheter balloon repair kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Catheter balloon repair kit. 870.1350 Section 870... repair kit. (a) Identification. A catheter balloon repair kit is a device used to repair or replace the balloon of a balloon catheter. The kit contains the materials, such as glue and balloons, necessary...

  20. 21 CFR 870.1350 - Catheter balloon repair kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Catheter balloon repair kit. 870.1350 Section 870... repair kit. (a) Identification. A catheter balloon repair kit is a device used to repair or replace the balloon of a balloon catheter. The kit contains the materials, such as glue and balloons, necessary...

  1. 49 CFR 173.165 - Polyester resin kits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Polyester resin kits. 173.165 Section 173.165... Polyester resin kits. (a) Polyester resin kits consisting of a base material component (Class 3, Packing..., according to the criteria for Class 3, applied to the base material. Additionally, polyester resin kits...

  2. 21 CFR 870.1350 - Catheter balloon repair kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Catheter balloon repair kit. 870.1350 Section 870... repair kit. (a) Identification. A catheter balloon repair kit is a device used to repair or replace the balloon of a balloon catheter. The kit contains the materials, such as glue and balloons, necessary...

  3. 21 CFR 868.1100 - Arterial blood sampling kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Arterial blood sampling kit. 868.1100 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Diagnostic Devices § 868.1100 Arterial blood sampling kit. (a) Identification. An arterial blood sampling kit is a device, in kit form, used to obtain arterial blood...

  4. 46 CFR 184.710 - First-aid kits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent...

  5. 46 CFR 184.710 - First-aid kits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent...

  6. 46 CFR 184.710 - First-aid kits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent...

  7. 46 CFR 184.710 - First-aid kits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent...

  8. 46 CFR 184.710 - First-aid kits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false First-aid kits. 184.710 Section 184.710 Shipping COAST... CONTROL AND MISCELLANEOUS SYSTEMS AND EQUIPMENT Miscellaneous § 184.710 First-aid kits. A vessel must carry either a first-aid kit approved under approval series 160.041 or a kit with equivalent...

  9. 19 CFR 122.132 - Sealing of aircraft liquor kits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Sealing of aircraft liquor kits. 122.132 Section... OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.132 Sealing of aircraft liquor kits. (a) Sealing required. Aircraft liquor kits shall be sealed on board the aircraft by crewmembers...

  10. Quality assurance for in vitro alternative test methods: quality control issues in test kit production.

    PubMed

    Rispin, Amy; Harbell, John W; Klausner, Mitchell; Jordan, Foster T; Coecke, Sandra; Gupta, Kailash; Stitzel, Katherine

    2004-06-01

    In vitro toxicology methods are being adopted by regulatory agencies worldwide. Many of these methods have been validated by using proprietary materials, often in the form of test kits. Guidelines for the use of Good Laboratory Practice methods for in vitro methods have been proposed. However, users of the data from these methods also need to be reassured that the proprietary materials and the test kits will provide consistent, good quality data over time, not just during the validation process. This paper presents an overview of the methods currently used by representatives of kit manufacturers and contract testing laboratories to ensure that the results from methods that utilise test kits are reproducible over time and across different types of test materials. This information will be valuable as a basis for future discussion on the need for formalised oversight of the quality of these materials.

  11. An evaluation of the performance of five extraction methods: Chelex® 100, QIAamp® DNA Blood Mini Kit, QIAamp® DNA Investigator Kit, QIAsymphony® DNA Investigator® Kit and DNA IQ™.

    PubMed

    Ip, Stephen C Y; Lin, Sze-Wah; Lai, Kam-Ming

    2015-05-01

    DNA left at a crime scene was often limited in amount and far from pristine. To maximize the chance of recovering as much information as possible from such compromised samples, an appropriate extraction method using the available technologies needs to be devised. In this study, we used human blood, buffy coat and a total of 76 simulated touch DNA samples to test the effectiveness of the following five common DNA extraction methods, namely, Chelex® 100, QIAamp® DNA Blood Mini Kit, QIAamp® DNA Investigator Kit, QIAsymphony® DNA Investigator® Kit and DNA IQ™ system, in the recovery of such DNA. We demonstrated that the QIAamp® and QIAsymphony® DNA Investigator® Kits, and the DNA IQ™ system, exhibited a better effectiveness in DNA recovery amongst these methods and yielded extracts with higher success rate in subsequent DNA profiling. These extracts also generated profiles with better intra-colour signal balance. The findings in this work allowed us to propose an extraction approach as follows: 1) casework samples shall be extracted with the QIAamp®/QIAsymphony® DNA Investigator® Kits or the DNA IQ™ system, viz., QIAsymphony® DNA Investigator® Kit and DNA IQ™, due to their higher throughput, are for the touched DNA evidence from the volume crime, while QIAamp® DNA Investigator Kit is preferable for challenging bloodstain samples; and 2) control samples, such as buccal swab, with known identity can be extracted with the Chelex, due to their cheaper cost per sample. Copyright © 2015 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

  12. A look at the purchase and use of home pregnancy-test kits.

    PubMed

    Coons, S J

    1989-04-01

    A study was conducted to obtain information regarding the purchase and use of home pregnancy-test kits. Questionnaires were distributed to 438 women entering a family-planning clinic in the fall of 1987. A total of 153 questionnaires were completed and returned, providing a response rate of 34.9%. Results indicated that nearly 40% of the respondents had used a home pregnancy-test kit at least once. Of those who had used a home pregnancy-test kit, the majority did so because of "the speed of obtaining results" or "convenience." Although nearly 87% of the pregnancy-test kits had been purchased in a pharmacy, pharmacists played only a minor role in the decision-making process concerning purchase and use. Some three-fourths of the subjects listed "information on the side of the package," "price," or "advertisements" as the most important factor in the selection of a specific brand of test kit. Only about 7% of the subjects selected "recommendation of the pharmacist" as the most important factor. The results suggest that pharmacists could be doing more to promote the appropriate use of self-testing products, specifically home pregnancy-test kits.

  13. Eponyms in forensic pathology.

    PubMed

    Nečas, Pavel; Hejna, Petr

    2012-12-01

    The phenomenon of eponymous terms in forensic pathology is described in this paper. The authors analyzed representative textbooks (monographs) dealing with forensic pathology in both English and German and identified several eponymous terms. The paper aims to present to the reader the most important eponymous terms in forensic pathology. Included in the paper are the following terms: Beckwith's Sign, Casper's Rule, Krönlein's Shot, Lichtenberg's Figures, Nysten's Law, Paltauf's Spots, Puppe's Rule, Sehrt's Sign, Simon's Sign, Sveshnikov's Sign, Tardieu's Spots, Wischnewski Spots, Wydler's Sign. The spread of eponymous terms throughout various languages is mentioned. The linguistic basis of such terms as well as their advantages and disadvantages in specialist fields, and indeed in even wider circles, is discussed. The authors state that the main function of these terms is to facilitate the open flow of unambiguous information among scholars. Eponymous terms in forensic pathology are characteristic for the German speaking countries and for all countries influenced by the German school of forensic pathology. Their usage in the Anglo-Saxon world is much less widespread, meaning they do not occur very often in English monographs and textbooks.

  14. Next-Generation Pathology.

    PubMed

    Caie, Peter D; Harrison, David J

    2016-01-01

    The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

  15. Resource Sharing. SPEC Kit 42.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    A 1977 Association of Research Libraries (ARL) survey indicated that nearly all respondents viewed enhanced access to needed information and service capabilities as the primary benefit of resource sharing. Most responding libraries participated in more than one type of resource sharing activity, ranging from informal understandings among a few…

  16. Pathological gambling.

    PubMed

    Hollander, E; Buchalter, A J; DeCaria, C M

    2000-09-01

    With increasing access to gambling facilities through casinos, the Internet, and other venues, PG is a rapidly emerging mental health concern. This impulse-control disorder tends to be comorbid with a wide range of other disorders and is reportedly associated with a high rate of suicide. For most gamblers, gambling is a form of entertainment, but for many individuals, the activity leads to far-reaching disruption of family and work. The personal and societal financial ramifications are severe, and many individuals with PG end up in the criminal justice system. An understanding of the neurobiology of PG is beginning to surface. 5-HT is linked to behavioral initiation and disinhibition, which are important in the onset of the gambling cycle and the difficulty in ceasing the behavior. Norepinephrine is associated with the arousal and risk taking in patients with PG. Dopamine is linked to positive and negative reward, the addictive component of this disorder. Effective treatment strategies for pathological gamblers are emerging. Potentially useful pharmacologic agents include SRIs (clomipramine and fluvoxamine), mood stabilizers for pathological gamblers with comorbid bipolar disorders (lithium), and naltrexone. Cognitive-behavioral psychotherapies offer promising results in the treatment of patients with this disorder. To devise prevention and early-intervention programs, research is needed to identify specific features of the individuals at risk for gambling problems. Education targeting vulnerable youth that show early signs of gambling behavior may be worthwhile and should be investigated further. Funding is necessary to support these endeavors, so perhaps a portion of tax revenues generated from the gambling industry should go toward specialized treatment facilities, educational efforts, and research into the neurobiology and treatment of PG.

  17. The Fluid Dynamics Demo Kit: Part I

    NASA Astrophysics Data System (ADS)

    Flack, Karen; Underhill, Patrick; Prestridge, Kathy

    2012-11-01

    The goal of this project is to develop a fluid dynamics demonstration/experiment kit that can be used by professors and graduate students at high school outreach events. The demonstrations in the kit will be easy to use and true crowd pleasers in order to inspire understanding and pique curiosity about the physics of flow. The kits will be inexpensive, containing readily available materials so that teachers can duplicate the demonstrations and experiments. The kits will be left with the teachers as a gift from the American Physics Society. The experiments and demonstrations cover the concepts of conservation of mass, momentum, and energy, Bernoulli's equation, frictional losses and the ideal gas law. For each experiment, the teachers will receive presentation material, access to instructional videos, plus a worksheet that can be used in a high school physics classroom. This kit has been developed through the efforts of the APS-DFD Mentoring and Outreach Committee and has received funding from the APS-DFD. Work funded by the APS-DFD.

  18. Control of Oocyte Reawakening by Kit

    PubMed Central

    Castrillon, Diego H.

    2016-01-01

    In mammals, females are born with finite numbers of oocytes stockpiled as primordial follicles. Oocytes are “reawakened” via an ovarian-intrinsic process that initiates their growth. The forkhead transcription factor Foxo3 controls reawakening downstream of PI3K-AKT signaling. However, the identity of the presumptive upstream cell surface receptor controlling the PI3K-AKT-Foxo3 axis has been questioned. Here we show that the receptor tyrosine kinase Kit controls reawakening. Oocyte-specific expression of a novel constitutively-active KitD818V allele resulted in female sterility and ovarian failure due to global oocyte reawakening. To confirm this result, we engineered a novel loss-of-function allele, KitL. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 protein localization in the nucleus versus cytoplasm explained both mutant phenotypes. These genetic studies provide formal genetic proof that Kit controls oocyte reawakening, focusing future investigations into the causes of primary ovarian insufficiency and ovarian aging. PMID:27500836

  19. Shuttle Kit Freezer Refrigeration Unit Conceptual Design

    NASA Technical Reports Server (NTRS)

    Copeland, R. J.

    1975-01-01

    The refrigerated food/medical sample storage compartment as a kit to the space shuttle orbiter is examined. To maintain the -10 F in the freezer kit, an active refrigeration unit is required, and an air cooled Stirling Cycle refrigerator was selected. The freezer kit contains two subsystems, the refrigeration unit, and the storage volume. The freezer must provide two basic capabilities in one unit. One requirement is to store 215 lbs of food which is consumed in a 30-day period by 7 people. The other requirement is to store 128.3 lbs of medical samples consisting of both urine and feces. The unit can be mounted on the lower deck of the shuttle cabin, and will occupy four standard payload module compartments on the forward bulkhead. The freezer contains four storage compartments.

  20. Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors.

    PubMed

    Merkelbach-Bruse, Sabine; Dietmaier, Wolfgang; Füzesi, Laszlo; Gaumann, Andreas; Haller, Florian; Kitz, Julia; Krohn, Antje; Mechtersheimer, Gunhild; Penzel, Roland; Schildhaus, Hans-Ulrich; Schneider-Stock, Regine; Simon, Ronald; Wardelmann, Eva

    2010-07-04

    Mutation analysis of KIT and PDGFRA genes in gastrointestinal stromal tumors is gaining increasing importance for prognosis of GISTs and for prediction of treatment response. Several groups have identified specific mutational subtypes in KIT exon 11 associated with an increased risk of metastatic disease whereas GISTs with PDGFRA mutations often behave less aggressive. Furthermore, in advanced GIST disease with proven KIT exon 9 mutation the doubled daily dose of 800 mg imatinib increases the progression free survival and is now recommended both in the European and the American Guidelines. In Germany, there are still no general rules how to perform mutational analysis. When comparing results from six different molecular laboratories we recognized the need of standardisation. Six German university laboratories with experience in mutation analysis in GISTs joined together to develop recommendations for the mutation analysis of the most common and clinically relevant hot spots, i. e. KIT exons 9 and 11 and PDGFRA exon 18. We performed a three-phased interlaboratory trial to identify pitfalls in performing molecular analysis in GISTs. We developed a design for a continuous external laboratory trial. In 2009 this external trial was conducted by 19 laboratories via the initiative for quality assurance in pathology (QuiP) of the German Society of Pathology and the Professional Association of German Pathologists. By performing a three-phased internal interlaboratory trial and conducting an external trial in Germany we were able to identify potential pitfalls when performing KIT and PDGFRA mutational analysis in gastrointestinal stromal tumors. We developed standard operation procedures which are provided with the manuscript to allow other laboratories to prevent these pitfalls.

  1. Management of CD-ROM Databases in ARL Libraries. SPEC Kit 169.

    ERIC Educational Resources Information Center

    Welch, C. Brigid, Ed.

    This kit is based on 73 responses to a survey conducted by the Association of Research Libraries (ARL) Office of Management Services to obtain information on the management of CD-ROM database installations in ARL libraries. The survey sought information in the areas of CD-ROM funding, instruction and publicity, organization, equipment, security,…

  2. Low Cost, Advanced, Integrated Microcontroller Training Kit

    NASA Astrophysics Data System (ADS)

    Somantri, Y.; Fushshilat, I.

    2017-03-01

    This paper describes the design of an AVR microcontroller training kit with a low cost and the additional feature of an integrated downloader. The main components of this device include: Microcontroller, terminal, I/O keypad, push button, LED, seven segment display, LCD, motor stepper, and sensors. The device configuration results in low cost and ease of use; this device is suitable for laboratories with limited funding. The device can also be used as a training kit for the teaching and learning of microcontrollers.

  3. FES kinase participates in KIT-ligand induced chemotaxis

    SciTech Connect

    Voisset, Edwige; Lopez, Sophie; Chaix, Amandine; Vita, Marina; George, Coralie; Dubreuil, Patrice; De Sepulveda, Paulo

    2010-02-26

    FES is a cytoplasmic tyrosine kinase activated by several membrane receptors, originally identified as a viral oncogene product. We have recently identified FES as a crucial effector of oncogenic KIT mutant receptor. However, FES implication in wild-type KIT receptor function was not addressed. We report here that FES interacts with KIT and is phosphorylated following activation by its ligand SCF. Unlike in the context of oncogenic KIT mutant, FES is not involved in wild-type KIT proliferation signal, or in cell adhesion. Instead, FES is required for SCF-induced chemotaxis. In conclusion, FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.

  4. FUELS IN SOIL TEST KIT: FIELD USE OF DIESEL DOG SOIL TEST KITS

    SciTech Connect

    Unknown

    2001-05-31

    Western Research Institute (WRI) is commercializing Diesel Dog Portable Soil Test Kits for performing analysis of fuel-contaminated soils in the field. The technology consists of a method developed by WRI (U.S. Patents 5,561,065 and 5,976,883) and hardware developed by WRI that allows the method to be performed in the field (patent pending). The method is very simple and does not require the use of highly toxic reagents. The aromatic components in a soil extract are measured by absorption at 254 nm with a field-portable photometer. WRI added significant value to the technology by taking the method through the American Society for Testing and Materials (ASTM) approval and validation processes. The method is designated ASTM Method D-5831-96, Standard Test Method for Screening Fuels in Soils. This ASTM designation allows the method to be used for federal compliance activities. In FY 99, twenty-five preproduction kits were successfully constructed in cooperation with CF Electronics, Inc., of Laramie, Wyoming. The kit components work well and the kits are fully operational. In the calendar year 2000, kits were provided to the following entities who agreed to participate as FY 99 and FY 00 JSR (Jointly Sponsored Research) cosponsors and use the kits as opportunities arose for field site work: Wyoming Department of Environmental Quality (DEQ) (3 units), F.E. Warren Air Force Base, Gradient Corporation, The Johnson Company (2 units), IT Corporation (2 units), TRC Environmental Corporation, Stone Environmental, ENSR, Action Environmental, Laco Associates, Barenco, Brown and Caldwell, Dames and Moore Lebron LLP, Phillips Petroleum, GeoSyntek, and the State of New Mexico. By early 2001, ten kits had been returned to WRI following the six-month evaluation period. On return, the components of all ten kits were fully functional. The kits were upgraded with circuit modifications, new polyethylene foam inserts, and updated instruction manuals.

  5. External Communication. SPEC Kit 56.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    One section of a spring 1979 Systems and Procedures Exchange Center (SPEC) survey on communication in Association of Research Libraries (ARL) institutions examined how members exchange information with external groups including the university administration, faculty, users, support groups, other libraries, and the profession in general. According…

  6. Kit system in the zebrafish ovary: evidence for functional divergence of two isoforms of kit (kita and kitb) and kit ligand (kitlga and kitlgb) during folliculogenesis.

    PubMed

    Yao, Kai; Ge, Wei

    2010-06-01

    The Kit system, including Kit ligand and its receptor Kit, has critical roles in mammalian reproduction, especially in the ovary. Unlike mammalian species, two copies of genes are present in the zebrafish genome for both ligand (kitlga and kitlgb) and receptor (kita and kitb). Phylogenetic and chromosome synteny analyses suggest that these duplicated genes were likely derived from the third round of genome duplication in vertebrate evolution. All four Kit system members were expressed in the zebrafish ovary, suggesting potential roles for the system in ovarian development and function. As the first step toward understanding the Kit system in the zebrafish ovary, especially the differential roles of different forms of ligand and receptor, the present study was undertaken to analyze the temporal expression profiles of the Kit system during folliculogenesis. All members of the Kit system exhibited significant and distinct variation in expression, particularly in the periovulatory period. During the transition from the primary growth to secondary growth, kitlga showed a dramatic increase, suggesting a role for Kit signaling in follicle recruitment. During final oocyte maturation, kitlga expression significantly decreased after a transitional surge before germinal vesicle breakdown, whereas all other members exhibited an increased expression, with kitlgb and kita reaching the peak expression levels in the ovulated eggs. Our results provide strong evidence that the Kit system is involved in regulating zebrafish ovarian function and that different isoforms of Kit and Kit ligand may have differential roles in folliculogenesis. This provides an example for neofunctionalization of duplicated genes in vertebrates.

  7. Preservation of Library Materials. SPEC Kit 35.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Association of Research Libraries (ARL) kit on preservation of library materials contains: (1) descriptions of preservation programs and objectives from Boston University, the University of Michigan, University of Wisconsin, and University of California at Los Angeles; (2) a description of the Library of Congress' National Preservation…

  8. Lead Paint Test Kits Workshop: Summary Report

    EPA Science Inventory

    The U.S. Environmental Protection Agency's (EPA) Office of Research and Development (ORD) designed and conducted the Lead Paint Test Kits Workshop on October 19 and 20, 2006, at the Environmental Protection Agency's Research Triangle Park, NC campus. The workshop was conducted as...

  9. 21 CFR 876.5210 - Enema kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Enema kit. 876.5210 Section 876.5210 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES... device intended to instill water or other fluids into the colon through a nozzle inserted into the rectum...

  10. Test kit testing certifies soil screening accuracy

    SciTech Connect

    Neal, L.K.

    1994-08-01

    With quality controls and validation, site managers can use immunoassay with confidence. It is not enough to know which hazardous substances have contaminated a site. A manager must have an idea about how much is present and where. Traditionally, gas chromatography and mass spectrometry answered these questions, but today immunoassay soil test kits often provide more immediate results at a lower cost.

  11. Earth Is My Home, Kit I.

    ERIC Educational Resources Information Center

    1971

    Introducing the pupil to the science of ecology is the purpose of Scholastic's Earth Corps Ecology/Conservation Study Kits for grades 3-6. Simple terms are used to show how all living things are inter-related to their environment, to demonstrate the intricate and delicate balance of nature, and to point out how man's interference with nature's…

  12. Managing Corporate Annual Reports. SPEC Kit 258.

    ERIC Educational Resources Information Center

    O'Connor, Lisa, Comp.

    2000-01-01

    The purpose of the survey for this SPEC (Systems and Procedures Exchange Center) Kit was to assess the current print corporate annual report collection practices of ARL (Association of Research Libraries) libraries, describe the effects of these collections, and recommend best practices for preserving these significant historical documents. The…

  13. Managing Corporate Annual Reports. SPEC Kit 258.

    ERIC Educational Resources Information Center

    O'Connor, Lisa, Comp.

    2000-01-01

    The purpose of the survey for this SPEC (Systems and Procedures Exchange Center) Kit was to assess the current print corporate annual report collection practices of ARL (Association of Research Libraries) libraries, describe the effects of these collections, and recommend best practices for preserving these significant historical documents. The…

  14. You Be the Chemist [Multimedia Kit].

    ERIC Educational Resources Information Center

    National Association of Chemical Distributors, Arlington, VA. Educational Foundation.

    This multimedia kit includes a teacher's manual, video, and activity packet. The unique interactive course uses safe, controlled dynamic experiments to teach kids about chemistry, the proper handling of chemicals, and responsible product stewardship. Students are asked to hypothesize about chemical substances, collect and analyze data, and share…

  15. You Be the Chemist [Multimedia Kit].

    ERIC Educational Resources Information Center

    National Association of Chemical Distributors, Arlington, VA. Educational Foundation.

    This multimedia kit includes a teacher's manual, video, and activity packet. The unique interactive course uses safe, controlled dynamic experiments to teach kids about chemistry, the proper handling of chemicals, and responsible product stewardship. Students are asked to hypothesize about chemical substances, collect and analyze data, and share…

  16. Beyond the Science Kit: Inquiry in Action.

    ERIC Educational Resources Information Center

    Saul, Wendy, Ed.; Reardon, Jeanne, Ed.

    The essays in this book are about values that are being used to drive science instruction in remarkable ways. The essays are divided into three sections. The first section contains two essays about science kits and determines the problem that the rest of the book addresses. The essays in the second section offer a glimpse of what five teachers see…

  17. Countdown to Six Billion Teaching Kit.

    ERIC Educational Resources Information Center

    Zero Population Growth, Inc., Washington, DC.

    This teaching kit features six activities focused on helping students understand the significance of the world population reaching six billion for our society and our environment. Featured activities include: (1) History of the World: Part Six Billion; (2) A Woman's Place; (3) Baby-O-Matic; (4) Earth: The Apple of Our Eye; (5) Needs vs. Wants; and…

  18. Press kit kicks off new branding.

    PubMed

    Rees, Tom

    2004-01-01

    A smartly produced press kit resulted in unprecedented news coverage when Denver's Porter Adventist Hospital recently unveiled plans for an extensive 80 million dollars redevelopment. A news conference was held to announce this plan, along with the opening of the hospital's new emergency department. The overall effort is part of the new branding strategy of the 75-year-old hospital.

  19. Reclassification Survey Results. SPEC Kit 16.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit presents the results of a survey conducted by the Association of Research Libraries (ARL) in 1974 to investigate and document various experiences of academic and research libraries in reclassifying portions of collections or entire collections and the relationship between libraries' particular classification schemes on effective…

  20. Library Systems Office Organization. SPEC Kit.

    ERIC Educational Resources Information Center

    Muir, Scott P., Comp.; Lim, Adriene, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to investigate the changes in research library systems operations since 1994 and to identify future trends. A total of 70 of 124 ARL member libraries responded to the survey. A copy of the…

  1. Earth Is My Home, Kit I.

    ERIC Educational Resources Information Center

    1971

    Introducing the pupil to the science of ecology is the purpose of Scholastic's Earth Corps Ecology/Conservation Study Kits for grades 3-6. Simple terms are used to show how all living things are inter-related to their environment, to demonstrate the intricate and delicate balance of nature, and to point out how man's interference with nature's…

  2. A Tool Kit for New Chairs

    ERIC Educational Resources Information Center

    Munro, Stuart

    2006-01-01

    Many chairs come to their position without the benefit of previous experience in the role of leading an academic department. The American Association of Chairs of Departments of Psychiatry (AACDP) identified the need for a manual designed to help a new chair get started. The "tool kit" that emerged contains sections that describe the AACDP,…

  3. SunWise[R] Meteorologist Tool Kit

    ERIC Educational Resources Information Center

    US Environmental Protection Agency, 2007

    2007-01-01

    The SunWise Program is designed to help meteorologists raise sun safety awareness by addressing the science of the sun, the risk of overexposure to its ultraviolet (UV) radiation, and what students and their families can do to protect themselves from overexposure. This Tool Kit has been designed for use all over the United States and its…

  4. Teacher to Teacher: Take-Home Kits.

    ERIC Educational Resources Information Center

    Franklin, Joyce; Krebill, Joyce

    1993-01-01

    Describes a kit containing mathematical enrichment activities and activity evaluation sheets that kindergarten students can complete at home. Thirteen sample activities involving weather, pattern recognition, counting, money, estimation, observation skills, weight, temperature, measurement, and time are included. Suggestions for utilization, care,…

  5. Post-Tenure Review. SPEC Kit 261.

    ERIC Educational Resources Information Center

    Hook, Sara Anne, Comp.; Lees, N. Doug, Comp.; Powers, Gerald, Comp.

    2000-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit reports results of a survey of ARL (Association of Research Libraries) that examined post-tenure review of librarians throughout higher education in North America. The purpose of the survey was to identify which institutions apply post-tenure or post-continuing appointment review to library…

  6. Electronic Reference Service. SPEC Kit 251.

    ERIC Educational Resources Information Center

    Goetsch, Lori, Comp.

    1999-01-01

    The goals of this SPEC Kit were to report on the extent to which ARL (Association of Research Libraries) libraries provide electronic reference services and to offer a snapshot of the types of users reached, questions received, policies established, data-gathering techniques utilized, and innovations implemented. The first section of the kit…

  7. Library Systems Office Organization. SPEC Kit.

    ERIC Educational Resources Information Center

    Muir, Scott P., Comp.; Lim, Adriene, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to investigate the changes in research library systems operations since 1994 and to identify future trends. A total of 70 of 124 ARL member libraries responded to the survey. A copy of the…

  8. Defense Acquisition University Program Managers Tool Kit

    DTIC Science & Technology

    2011-01-01

    International Standards Organization ( ISO ) registration of a supplier’s quality system since there have been instances where ISO 9001 -registered supplier...58 Quality Management Systems (Defense Acquisition Guidebook...facilities and equipment. DAU PROGRAM MANAGERS TOOL KIT 59 Quality Management Systems (see Defense Acquisition Guidebook) • The PM should allow

  9. Managerial and Technical Specialists. SPEC Kit 20.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit is compiled from documentation received as a result of a 1975 Association of Research Libraries (ARL) survey on the use of specialists in member libraries; updated materials gathered in 1978 are included. Survey data from 64 ARL members indicate wide utilization of various managerial and technical specialists. Of these, personnel…

  10. Thermal protection system flight repair kit

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A thermal protection system (TPS) flight repair kit required for use on a flight of the Space Transportation System is defined. A means of making TPS repairs in orbit by the crew via extravehicular activity is discussed. A cure in place ablator, a precured ablator (large area application), and packaging design (containers for mixing and dispensing) for the TPS are investigated.

  11. Computerized Online Bibliographic Searching. SPEC Kit #154.

    ERIC Educational Resources Information Center

    Hocker, Susan

    For this kit, 106 Association of Research Libraries (ARL) academic libraries were surveyed concerning: (1) current administration/organization; (2) evaluation; (3) patron relations; (4) services; and (5) the impact of online searching on collections. Responses were received from 83 libraries, many of which contributed sample materials. Analyses of…

  12. Learning Disabilities In-Service Training Kit.

    ERIC Educational Resources Information Center

    Simpson, Bickley

    Included in the training kit for teachers in the area of learning disabilities are materials developed by Project Lighthouse for experimental field usage to test the materials. The problem of educating children with learning disabilities is summarized, as is Piaget's model of logical activity. The major divisions of the text then deal with the…

  13. Lead Paint Test Kits Workshop: Summary Report

    EPA Science Inventory

    The U.S. Environmental Protection Agency's (EPA) Office of Research and Development (ORD) designed and conducted the Lead Paint Test Kits Workshop on October 19 and 20, 2006, at the Environmental Protection Agency's Research Triangle Park, NC campus. The workshop was conducted as...

  14. Career and Occupational Development Kit. Instruction Manual.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. National Assessment of Educational Progress.

    This manual is part of a kit consisting of four documents which bring together different types of items that measure a number of career and occupational development (COD) objectives developed by the National Assessment of Educational Progress (NAEP). (NAEP--which completed a national survey measuring the achievement of knowledge, skills,…

  15. Library Photocopy Operations. SPEC Kit 209.

    ERIC Educational Resources Information Center

    Almony, Robert A., Jr., Comp.; O'Brien, Francis, Comp.

    The kit and flyer examine library photocopy operations, including services, personnel, equipment, and financial management practices by member institutions of the Association of Research Libraries (ARL). To find out about these operations, ARL surveyed its 112 members, and received 93 replies. Forty-nine academic libraries (58%) described their…

  16. Career and Occupational Development Kit. Instruction Manual.

    ERIC Educational Resources Information Center

    Education Commission of the States, Denver, CO. National Assessment of Educational Progress.

    This manual is part of a kit consisting of four documents which bring together different types of items that measure a number of career and occupational development (COD) objectives developed by the National Assessment of Educational Progress (NAEP). (NAEP--which completed a national survey measuring the achievement of knowledge, skills,…

  17. Preservation of Library Materials. SPEC Kit 35.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Association of Research Libraries (ARL) kit on preservation of library materials contains: (1) descriptions of preservation programs and objectives from Boston University, the University of Michigan, University of Wisconsin, and University of California at Los Angeles; (2) a description of the Library of Congress' National Preservation…

  18. Beyond the Science Kit: Inquiry in Action.

    ERIC Educational Resources Information Center

    Saul, Wendy, Ed.; Reardon, Jeanne, Ed.

    The essays in this book are about values that are being used to drive science instruction in remarkable ways. The essays are divided into three sections. The first section contains two essays about science kits and determines the problem that the rest of the book addresses. The essays in the second section offer a glimpse of what five teachers see…

  19. Reclassification Survey Results. SPEC Kit 16.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit presents the results of a survey conducted by the Association of Research Libraries (ARL) in 1974 to investigate and document various experiences of academic and research libraries in reclassifying portions of collections or entire collections and the relationship between libraries' particular classification schemes on effective…

  20. Managerial and Technical Specialists. SPEC Kit 20.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This kit is compiled from documentation received as a result of a 1975 Association of Research Libraries (ARL) survey on the use of specialists in member libraries; updated materials gathered in 1978 are included. Survey data from 64 ARL members indicate wide utilization of various managerial and technical specialists. Of these, personnel…

  1. Gifts & Exchange Functions. SPEC Kit 28.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This collection contains data from a 1976 survey on organization, staffing, and operation of the gifts and exchange functions of member libraries of the Association of Research Libraries (ARL) and 26 primary source documents. Source documents in the kit include: (1) annual reports from Columbia University, University of North Carolina, and Ohio…

  2. The Interview Process. SPEC Kit 260.

    ERIC Educational Resources Information Center

    Frank, Heidi, Comp.; Nicholson, Shawn, Comp.; Dickson, Laura, Comp.; Miller, Terri Tickle, Comp.

    2000-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit reports results of a survey of ARL (Association of Research Libraries) that examined the nature and structure of the interview process at large research and academic libraries in the United States and Canada. By determining the nature and structure of the interview, it is hoped that candidates…

  3. Library Development and Fundraising. SPEC Kit 193.

    ERIC Educational Resources Information Center

    Claassen, Lynda Corey, Comp.

    This kit developed by the Systems and Procedures Exchange Center (SPEC) of the Association of Research Libraries (ARL) presents results of a survey of development and fundraising activities in libraries that are members of ARL, as well as some sample documents used in connection with development and fundraising. Eighty-seven institutions…

  4. Reference Service Statistics & Assessment. SPEC Kit.

    ERIC Educational Resources Information Center

    Novotny, Eric, Comp.

    2002-01-01

    This SPEC (Systems and Procedures Exchange Center) Kit presents the results of a survey of Association of Research Libraries (ARL) member libraries designed to document how ARL member libraries are collecting, using, and modifying their data on reference service transactions. A total of 74 of 124 ARL member libraries responded to the survey. A…

  5. KIT is an independent prognostic marker for pancreatic endocrine tumors: a finding derived from analysis of islet cell differentiation markers.

    PubMed

    Zhang, Lizhi; Smyrk, Thomas C; Oliveira, Andre M; Lohse, Christine M; Zhang, Shuya; Johnson, Michele R; Lloyd, Ricardo V

    2009-10-01

    Prediction of the biologic behavior of pancreatic endocrine tumor (PET) without local invasion or metastasis is often difficult. The 2004 World Health Organization (WHO) classification uses size, angioinvasion, mitotic activity, and Ki-67 index as prognostic criteria. Recently, cytokeratin 19 (CK19) was shown to be another prognostic marker, but the mechanism by which CK19 predicts prognosis is unknown. As CK19 is the first cytokeratin expressed in all epithelial cells in fetal pancreas, we sought to test expression of other markers of islet cell differentiation including KIT, Pdx-1, Pax4, and Pax6 in PET and correlation of these markers with clinical behavior. Clinical information and histology was reviewed in 97 PETs. All tumors were classified according to WHO criteria and a tumor, node, and metastases stage system. Immunohistochemistry was performed using antibodies to Ki-67, KIT, CK19, Pdx-1, Pax4, and Pax6. Associations of clinicopathologic and immunohistochemical features with prognosis were evaluated using Cox proportional hazards regression models. WHO and tumor, node, and metastases classifications, mitotic counts and Ki-67 labeling, infiltrative border, necrosis, perineural invasion, extrapancreatic extension, tumor size, and positive CK19 and KIT expression were significantly associated with death from disease in a univariate setting. In multivariate analysis, only WHO criteria and KIT expression were shown to be independent. An immunohistochemical classification system was derived from a combination of KIT and CK19 expression: low risk (KIT-/CK19-), intermediate risk (KIT-/CK19+), and high risk (KIT+/CK19+). Survival, metastases, and recurrence of PET were significantly different among the 3 groups. These results indicate that KIT is a new and independent prognostic marker for PETs. The classification system derived from KIT and CK19 was able to predict clinical behavior of PET.

  6. 49 CFR 173.161 - Chemical kits and first aid kits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... so there will be no possibility of the mixture of contents causing dangerous evolution of heat or gas... (Carriage by highway) of this subchapter except § 177.817 (Shipping papers). Kits that meet the definition...

  7. Test/QA Plan for Verification of Microcystin Test Kits

    EPA Science Inventory

    Microcystin test kits are used to quantitatively measure total microcystin in recreational waters. These test kits are based on enzyme-linked immunosorbent assays (ELISA) with antibodies that bind specifically to microcystins or phosphate activity inhibition where the phosphatas...

  8. 21 CFR 872.3570 - OTC denture repair kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3570 OTC denture repair kit. (a) Identification. An OTC denture repair kit is a device consisting of a material, such as a resin monomer system of...

  9. Test/QA Plan for Verification of Microcystin Test Kits

    EPA Science Inventory

    Microcystin test kits are used to quantitatively measure total microcystin in recreational waters. These test kits are based on enzyme-linked immunosorbent assays (ELISA) with antibodies that bind specifically to microcystins or phosphate activity inhibition where the phosphatas...

  10. C-kit overexpression correlates with KIT gene copy numbers increases in phyllodes tumors of the breast.

    PubMed

    Liu, Junjun; Liu, Xiaozhen; Feng, Xiaolong; Liu, Jian; Lv, Shuhua; Zhang, Wei; Niu, Yun

    2015-01-01

    We determined c-kit expression in the stroma and epithelia of benign, borderline, and malignant phyllodes tumors (PTs), respectively, as well as the relationship between c-kit expression in stromal elements and KIT gene copy number variations (CNVs). To assess c-kit expression and KIT CNVs, 348 PT cases were studied: 120 (34.4 %) benign cases, 115 (33.1 %) borderline cases, and 113 (32.5 %) malignant cases. All of these cases were evaluated for c-kit (CD117) expression using immunohistochemistry. Forty-two cases (29 c-kit-positive in the stromal cells cases and 13 negative cases) were investigated for KIT gene CNVs via genomic polymerase chain reaction (PCR). The overall rate of c-kit positivity in the stroma was 46.8 %, as well as 24.2, 53.1, and 64.6 %, respectively, in PTs of three different grades. However, in the majority of cases, the epithelia were c-kit positive (98.2 %), and the positivity was 100, 99.1, and 95 % in PTs of three different grades, respectively. There was a significant change in the expression of c-kit in the stroma and epithelia according to grade (P < 0.001, P = 0.014). From the genomic PCR results, we can confirm that c-kit positivity in the stroma is directly correlated with KIT gene copy numbers increases (P = 0.003, P = 0.041). We demonstrated that c-kit expression in the stroma of PTs is positively associated with malignancy. c-Kit epithelial positivity was inversely correlated with PTs malignancy. c-Kit overexpression in the stroma was related to KIT gene copy numbers increases.

  11. L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition.

    PubMed

    Antonescu, Cristina R; Busam, Klaus J; Francone, Todd D; Wong, Grace C; Guo, Tianhua; Agaram, Narasimhan P; Besmer, Peter; Jungbluth, Achim; Gimbel, Mark; Chen, Chin-Tung; Veach, Darren; Clarkson, Bayard D; Paty, Philip B; Weiser, Martin R

    2007-07-15

    Activating mutations in either BRAF or NRAS are seen in a significant number of malignant melanomas, but their incidence appears to be dependent to ultraviolet light exposure. Thus, BRAF mutations have the highest incidence in non-chronic sun damaged (CSD), and are uncommon in acral, mucosal and CSD melanomas. More recently, activating KIT mutations have been described in rare cases of metastatic melanoma, without further reference to their clinical phenotypes. This finding is intriguing since KIT expression is downregulated in most melanomas progressing to more aggressive lesions. In this study, we investigated a group of anal melanomas for the presence of BRAF, NRAS, KIT and PDGFRA mutations. A heterozygous KIT exon 11 L576P substitution was identified in 3 of 20 cases tested. The 3 KIT mutation-carrying tumors were strongly immunopositive for KIT protein. No KIT mutations were identified in tumors with less than 4+ KIT immunostaining. NRAS mutation was identified in one tumor. No BRAF or PDGFRA mutations were identified in either KIT positive or negative anal melanomas. In vitro drug testing of stable transformant Ba/F3 KIT(L576P) mutant cells showed sensitivity for dasatinib (previously known as BMS-354825), a dual SRC/ABL kinase inhibitor, and imatinib. However, compared to an imatinib-sensitive KIT mutant, dasatinib was potent at lower doses than imatinib in the KIT(L576P) mutant. These results suggest that a subset of anal melanomas show activating KIT mutations, which are susceptible for therapy with specific kinase inhibitors.

  12. 46 CFR 121.710 - First-aid kits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”....

  13. 46 CFR 121.710 - First-aid kits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”....

  14. 46 CFR 121.710 - First-aid kits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”....

  15. 46 CFR 121.710 - First-aid kits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”....

  16. 46 CFR 121.710 - First-aid kits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false First-aid kits. 121.710 Section 121.710 Shipping COAST... SYSTEMS AND EQUIPMENT Miscellaneous § 121.710 First-aid kits. A vessel must carry either a first-aid kit... kits, the contents must be stowed in a suitable, watertight container that is marked “First-Aid Kit”....

  17. 21 CFR 880.5760 - Chemical cold pack snakebite kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Chemical cold pack snakebite kit. 880.5760 Section... Therapeutic Devices § 880.5760 Chemical cold pack snakebite kit. (a) Identification. A chemical cold pack snakebit kit is a device consisting of a chemical cold pack and tourniquet used for first-aid treatment...

  18. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... criteria in paragraph (c) of this section. (b) No other test kits will be recognized until they are tested... response criteria in paragraph (c)(1) of this section. The recognition of kits that meet only this criteria... in paragraph (c) of this section. (4) After September 1, 2010, test kits must meet both of...

  19. 21 CFR 880.5760 - Chemical cold pack snakebite kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Chemical cold pack snakebite kit. 880.5760 Section... Therapeutic Devices § 880.5760 Chemical cold pack snakebite kit. (a) Identification. A chemical cold pack snakebit kit is a device consisting of a chemical cold pack and tourniquet used for first-aid treatment...

  20. 21 CFR 880.5760 - Chemical cold pack snakebite kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Chemical cold pack snakebite kit. 880.5760 Section... Therapeutic Devices § 880.5760 Chemical cold pack snakebite kit. (a) Identification. A chemical cold pack snakebit kit is a device consisting of a chemical cold pack and tourniquet used for first-aid treatment...

  1. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... criteria in paragraph (c) of this section. (b) No other test kits will be recognized until they are tested... response criteria in paragraph (c)(1) of this section. The recognition of kits that meet only this criteria... in paragraph (c) of this section. (4) After September 1, 2010, test kits must meet both of...

  2. 19 CFR 122.132 - Sealing of aircraft liquor kits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... protection. (c) Seals to be used. Aircraft liquor kits shall be sealed with serially numbered, Customs... 19 Customs Duties 1 2011-04-01 2011-04-01 false Sealing of aircraft liquor kits. 122.132 Section... OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.132 Sealing of aircraft...

  3. 32 CFR 105.12 - SAFE Kit collection and preservation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false SAFE Kit collection and preservation. 105.12..., MILITARY AND CIVILIAN SEXUAL ASSAULT PREVENTION AND RESPONSE PROGRAM PROCEDURES § 105.12 SAFE Kit... ability to elect a SAFE Kit in addition to the general medical management related to sexual...

  4. 19 CFR 122.132 - Sealing of aircraft liquor kits.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... protection. (c) Seals to be used. Aircraft liquor kits shall be sealed with serially numbered, Customs... 19 Customs Duties 1 2014-04-01 2014-04-01 false Sealing of aircraft liquor kits. 122.132 Section... OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.132 Sealing of aircraft...

  5. 19 CFR 122.132 - Sealing of aircraft liquor kits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... protection. (c) Seals to be used. Aircraft liquor kits shall be sealed with serially numbered, Customs... 19 Customs Duties 1 2012-04-01 2012-04-01 false Sealing of aircraft liquor kits. 122.132 Section... OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.132 Sealing of aircraft...

  6. 21 CFR 880.5760 - Chemical cold pack snakebite kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Chemical cold pack snakebite kit. 880.5760 Section... Therapeutic Devices § 880.5760 Chemical cold pack snakebite kit. (a) Identification. A chemical cold pack snakebit kit is a device consisting of a chemical cold pack and tourniquet used for first-aid treatment...

  7. 21 CFR 880.5760 - Chemical cold pack snakebite kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Chemical cold pack snakebite kit. 880.5760 Section... Therapeutic Devices § 880.5760 Chemical cold pack snakebite kit. (a) Identification. A chemical cold pack snakebit kit is a device consisting of a chemical cold pack and tourniquet used for first-aid treatment...

  8. 40 CFR 745.88 - Recognized test kits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... criteria in paragraph (c) of this section. (b) No other test kits will be recognized until they are tested... response criteria in paragraph (c)(1) of this section. The recognition of kits that meet only this criteria... in paragraph (c) of this section. (4) After September 1, 2010, test kits must meet both of...

  9. 19 CFR 122.132 - Sealing of aircraft liquor kits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... protection. (c) Seals to be used. Aircraft liquor kits shall be sealed with serially numbered, Customs... 19 Customs Duties 1 2013-04-01 2013-04-01 false Sealing of aircraft liquor kits. 122.132 Section... OF THE TREASURY AIR COMMERCE REGULATIONS Aircraft Liquor Kits § 122.132 Sealing of aircraft...

  10. Working with Self-Injurious Adolescents Using the Safe Kit

    ERIC Educational Resources Information Center

    Moyer, Michael

    2008-01-01

    This article offers a guide for using the Safe Kit when working with clients who self-injure. The Safe Kit can be used as a supplement to more traditional approaches to counseling and offers clients alternatives to self-injury when they need alternatives the most. The Safe Kit works under the assumption that individuals differ in the meaning they…

  11. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  12. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  13. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  14. 33 CFR 144.01-30 - First-aid kit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false First-aid kit. 144.01-30 Section...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit. On each manned platform a first-aid kit approved by the Commandant or the U.S. Bureau of Mines shall...

  15. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter....

  16. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter....

  17. 46 CFR 108.707 - First aid kit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine...

  18. 33 CFR 144.01-30 - First-aid kit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false First-aid kit. 144.01-30 Section...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit. On each manned platform a first-aid kit approved by the Commandant or the U.S. Bureau of Mines shall...

  19. 33 CFR 144.01-30 - First-aid kit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false First-aid kit. 144.01-30 Section...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit. On each manned platform a first-aid kit approved by the Commandant or the U.S. Bureau of Mines shall...

  20. 46 CFR 108.707 - First aid kit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine...

  1. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter....

  2. 46 CFR 108.707 - First aid kit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine...

  3. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter....

  4. 46 CFR 169.725 - First aid kit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false First aid kit. 169.725 Section 169.725 Shipping COAST... Control, Miscellaneous Systems, and Equipment § 169.725 First aid kit. Each vessel must carry an approved first aid kit, constructed and fitted in accordance with subpart 160.041 of this chapter....

  5. 33 CFR 144.01-30 - First-aid kit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false First-aid kit. 144.01-30 Section...) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit. On each manned platform a first-aid kit approved by the Commandant or the U.S. Bureau of Mines shall...

  6. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  7. 21 CFR 878.3925 - Plastic surgery kit and accessories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Plastic surgery kit and accessories. 878.3925... (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES Prosthetic Devices § 878.3925 Plastic surgery kit and accessories. (a) Identification. A plastic surgery kit and accessories is a device intended to...

  8. 21 CFR 880.5740 - Suction snakebite kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Suction snakebite kit. 880.5740 Section 880.5740... Devices § 880.5740 Suction snakebite kit. (a) Identification. A suction snakebite kit is a device consisting of a knife, suction device, and tourniquet used for first-aid treatment of snakebites by removing...

  9. 21 CFR 868.5140 - Anesthesia conduction kit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  10. 21 CFR 868.5140 - Anesthesia conduction kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  11. 21 CFR 868.5140 - Anesthesia conduction kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  12. 21 CFR 868.5140 - Anesthesia conduction kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  13. 21 CFR 868.5140 - Anesthesia conduction kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Anesthesia conduction kit. 868.5140 Section 868...) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5140 Anesthesia conduction kit. (a) Identification. An anesthesia conduction kit is a device used to administer to a patient conduction, regional, or...

  14. Home Pregnancy Test Kits: How Readable Are the Instructions?

    ERIC Educational Resources Information Center

    Holcomb, Carol Ann

    At the conclusion of their study on home pregnancy test kits, Valinas and Perlman (1982) suggested that the instructions accompanying the kits be revised to make them easier to read. A study was undertaken to determine the readability of the printed instructions accompanying five home pregnancy test kits (Daisy II, Answer, Acu-Test, Predictor, and…

  15. 46 CFR 108.707 - First aid kit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine...

  16. 46 CFR 108.707 - First aid kit.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false First aid kit. 108.707 Section 108.707 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Miscellaneous Equipment § 108.707 First aid kit. Each unit must have a first-aid kit approved by the Mine...

  17. Audit of lymphadenectomy in lung cancer resections using a specimen collection kit and checklist

    PubMed Central

    Osarogiagbon, Raymond U.; Sareen, Srishti; Eke, Ransome; Yu, Xinhua; McHugh, Laura M.; Kernstine, Kemp H.; Putnam, Joe B.; Robbins, Edward T.

    2014-01-01

    Background Audits of operative summaries and pathology reports reveal wide discordance in identifying the extent of lymphadenectomy performed (the communication gap). We tested the ability of a pre-labeled lymph node specimen collection kit and checklist to narrow the communication gap between operating surgeons, pathologists, and auditors of surgeons’ operation notes. Methods We conducted a prospective single cohort study of lung cancer resections performed with a lymph node collection kit from November 2010 to January 2013. We used the kappa statistic to compare surgeon claims on a checklist of lymph node stations harvested intraoperatively, to pathology reports, and an independent audit of surgeons’ operative summaries. Lymph node collection procedures were classified into 4 groups based on the anatomic origin of resected lymph nodes: mediastinal lymph node dissection, systematic sampling, random sampling and no sampling. Results From the pathology report, 73% of 160 resections had a mediastinal lymph node dissection or systematic sampling procedure, 27% had random sampling. The concordance with surgeon claims was 80% (kappa statistic 0.69 [CI 0.60 – 0.79]). Concordance between independent audits of the operation notes and either the pathology report (kappa 0.14 [0.04 – 0.23]), or surgeon claims (kappa 0.09 [0.03 – 0.22]), was poor. Conclusion A pre-labeled specimen collection kit and checklist significantly narrowed the communication gap between surgeons and pathologists in identifying the extent of lymphadenectomy. Audit of surgeons’ operation notes did not accurately reflect the procedure performed, bringing its value for quality improvement work into question. PMID:25530090

  18. Audit of lymphadenectomy in lung cancer resections using a specimen collection kit and checklist.

    PubMed

    Osarogiagbon, Raymond U; Sareen, Srishti; Eke, Ransome; Yu, Xinhua; McHugh, Laura M; Kernstine, Kemp H; Putnam, Joe B; Robbins, Edward T

    2015-02-01

    Audits of operative summaries and pathology reports reveal wide discordance in identifying the extent of lymphadenectomy performed (the communication gap). We tested the ability of a prelabeled lymph node specimen collection kit and checklist to narrow the communication gap between operating surgeons, pathologists, and auditors of surgeons' operation notes. We conducted a prospective single cohort study of lung cancer resections performed with a lymph node collection kit from November 2010 to January 2013. We used the kappa statistic to compare surgeon claims on a checklist of lymph node stations harvested intraoperatively with pathology reports and an independent audit of surgeons' operative summaries. Lymph node collection procedures were classified into four groups based on the anatomic origin of resected lymph nodes: mediastinal lymph node dissection, systematic sampling, random sampling, and no sampling. From the pathology reports, 73% of 160 resections had a mediastinal lymph node dissection or systematic sampling procedure, 27% had random sampling. The concordance with surgeon claims was 80% (kappa statistic 0.69, 95% confidence interval: 0.60 to 0.79). Concordance between independent audits of the operation notes and either the pathology report (kappa 0.14, 95% confidence interval: 0.04 to 0.23) or surgeon claims (kappa 0.09, 95% confidence interval: 0.03 to 0.22) was poor. A prelabeled specimen collection kit and checklist significantly narrowed the communication gap between surgeons and pathologists in identifying the extent of lymphadenectomy. Audit of surgeons' operation notes did not accurately reflect the procedure performed, bringing its value for quality improvement work into question. Copyright © 2015 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  19. Curriculum Guidelines for Pathology and Oral Pathology.

    ERIC Educational Resources Information Center

    Journal of Dental Education, 1985

    1985-01-01

    Guidelines for dental school pathology courses describe the interrelationships of general, systemic, and oral pathology; primary educational goals; prerequisites; a core curriculum outline and behavioral objectives for each type of pathology. Notes on sequencing, faculty, facilities, and occupational hazards are included. (MSE)

  20. Operational feasibility of rapid diagnostic kits & blister packs use for malaria control in high transmission areas of Orissa & Chhattisgarh.

    PubMed

    Reetha, A M; Sharma, S K; Tyagi, P K; Valecha, Neena; Nagpal, B N; Dash, A P

    2007-01-01

    Early diagnosis and prompt treatment of cases with malaria are two important components of malaria control strategy. The independent assessment of the operational feasibility of rapid diagnostic kits and blister packs for malaria in some selected high transmission areas of Orissa and Chhattisgarh was done with the objectives to assess the knowledge and skills of the paramedical personnel and their acceptability by the paramedical personnel and the community, and to assess improvement in patients' health seeking behaviour. The basic information regarding malaria situation, epidemiological divisions, distribution data of rapid diagnostic kits and blister packs, etc., was collected from State and district headquarters. The subcentres from the primary health centres/community health centres were selected on the basis of supply of rapid diagnostic kits and blister packs. The subcentres were visited and health personnel interviewed about their knowledge and skills on the use of rapid diagnostic kits and blister packs. A cross-sectional survey was conducted to assess the public opinion about rapid diagnostic kits and blister packs. We found that the paramedicals were well trained in the use of rapid diagnostic kits and blister pack administration and the acceptance was good by both paramedicals and general public. The compliance rate of radical treatment with blister packs was 100 per cent and no adverse events were reported. Our findings showed that rapid diagnostic kits and blister packs under remote and inaccessible highly malarious areas can be introduced that will have significant impact in reducing malaria morbidity and mortality.

  1. Commercial Milk Enzyme-Linked Immunosorbent Assay (ELISA) Kit Reactivities to Purified Milk Proteins and Milk-Derived Ingredients.

    PubMed

    Ivens, Katherine O; Baumert, Joseph L; Taylor, Steve L

    2016-07-01

    Numerous commercial enzyme-linked immunosorbent assay (ELISA) kits exist to quantitatively detect bovine milk residues in foods. Milk contains many proteins that can serve as ELISA targets including caseins (α-, β-, or κ-casein) and whey proteins (α-lactalbumin or β-lactoglobulin). Nine commercially-available milk ELISA kits were selected to compare the specificity and sensitivity with 5 purified milk proteins and 3 milk-derived ingredients. All of the milk kits were capable of quantifying nonfat dry milk (NFDM), but did not necessarily detect all individual protein fractions. While milk-derived ingredients were detected by the kits, their quantitation may be inaccurate due to the use of different calibrators, reference materials, and antibodies in kit development. The establishment of a standard reference material for the calibration of milk ELISA kits is increasingly important. The appropriate selection and understanding of milk ELISA kits for food analysis is critical to accurate quantification of milk residues and informed risk management decisions.

  2. Optimizing Medical Kits for Space Flight

    NASA Technical Reports Server (NTRS)

    Minard, Charles G.; FreiredeCarvalho, Mary H.; Iyengar, M. Sriram

    2010-01-01

    The Integrated Medical Model (IMM) uses Monte Carlo methodologies to predict the occurrence of medical events, their mitigation, and the resources required during space flight. The model includes two modules that utilize output from a single model simulation to identify an optimized medical kit for a specified mission scenario. This poster describes two flexible optimization routines built into SAS 9.1. The first routine utilizes a systematic process of elimination to maximize (or minimize) outcomes subject to attribute constraints. The second routine uses a search and mutate approach to minimize medical kit attributes given a set of outcome constraints. There are currently 273 unique resources identified that are used to treat at least one of 83 medical conditions currently in the model.

  3. Kit Tests for Rapid Detection of Viable Bacteria and Viruses.

    DTIC Science & Technology

    1980-10-01

    Kit test Bacteria detection Kit bacteria Rapid detection Virus detection Viruses p-Iodonitrotetrazoiiu Viable bacteria Field kit Nucleic acid 21L...AD-A091 796 GEOMET TECHNOLOGIES INC GAITHERSBURG MD F/6 15/2 KIT TESTS FOR RAPID DETECTION OF VIABLE BACTERIA AND VIRUSES . IU) OCT V0 R N MOYER DAAKI...34 ®,,LEYE V TŘ CHEMICAL SYSTEMS LABORATORY CONTRACTOR REPORTo ARCSL-CR-80064 KIT TESTS FOR RAPID DETECTION OF VIABLE BACTERIA AND VIRUSES Final Report by R.H

  4. Sample rotating turntable kit for infrared spectrometers

    DOEpatents

    Eckels, Joel Del; Klunder, Gregory L.

    2008-03-04

    An infrared spectrometer sample rotating turntable kit has a rotatable sample cup containing the sample. The infrared spectrometer has an infrared spectrometer probe for analyzing the sample and the rotatable sample cup is adapted to receive the infrared spectrometer probe. A reflectance standard is located in the rotatable sample cup. A sleeve is positioned proximate the sample cup and adapted to receive the probe. A rotator rotates the rotatable sample cup. A battery is connected to the rotator.

  5. ParenTech: Parenting in a Digital Age. ParenTech Resource Kit.

    ERIC Educational Resources Information Center

    Ameritech Foundation, Chicago, IL.

    ParenTech is a technology information initiative designed to educate families about the impact technology has on the ways children learn, work, and live. Designed for parents of middle school students (grades 6-8), the ParenTech Resource Kit contains the following materials: (1) a poster that outlines suggested activities for promoting the value…

  6. Staff Recognition Awards in ARL Libraries. SPEC (Systems and Procedures Exchange Center) Kit #173.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    For this kit, 119 Association of Research Libraries (ARL) member libraries were surveyed to ascertain the extent of employee award programs. The survey focused on identifying how many member libraries have an employee award program and also gathered information on the nature of these programs. Questions were designed to identify what is rewarded,…

  7. Validation testing of a portable kit for measuring an active soil carbon fraction

    EPA Science Inventory

    Increasing demands exist for information about properties related to soil quality and human-induced soil change, particularly soil C. To help address this need, the USDA-NRCS Soil Survey Laboratory (SSL) developed a portable kit for rapid and relatively accurate assessment of soi...

  8. Experiments That Walk: Four Self-Study Units with Portable Kits for Introductory Physics.

    ERIC Educational Resources Information Center

    Brunschwig, Fernand

    This is a report of the development of four self-study units in physics for college nonscience majors. The topics of the units are Waves and Sound, The Radiant Energy of Sunlight, Infrared Radiation, and Acceleration. Each unit includes an inexpensive, portable kit; a student manual containing all requisite background information, self-test,…

  9. The Power of Prevention: Invest in It. Crime Prevention Month Action Kit, October 1998.

    ERIC Educational Resources Information Center

    Kirby, Judy; Asato, Cathy

    This kit from the Crime Prevention Coalition of America provides information about crime prevention, the history of crime prevention month, and materials for use in creating and hosting crime prevention programs and events. Contents include (1) "The Results of Investing in Crime Prevention"; (2) "Sample Press Release"; (3)…

  10. Cataloging of Resources Digitized for Preservation. SPEC Kit 249 [and] SPEC Flyer 249.

    ERIC Educational Resources Information Center

    Reed-Scott, Jutta, Comp.

    1999-01-01

    This SPEC (Systems Procedures and Exchange Center) Kit and Flyer summarizes results of a survey of ARL (Association of Research Libraries) members that was designed to gather information about current approaches to bibliographic control of materials digitized for preservation. The survey is intentionally limited to the cataloging treatment of…

  11. Validation testing of a portable kit for measuring an active soil carbon fraction

    EPA Science Inventory

    Increasing demands exist for information about properties related to soil quality and human-induced soil change, particularly soil C. To help address this need, the USDA-NRCS Soil Survey Laboratory (SSL) developed a portable kit for rapid and relatively accurate assessment of soi...

  12. Experiments That Walk: Four Self-Study Units with Portable Kits for Introductory Physics.

    ERIC Educational Resources Information Center

    Brunschwig, Fernand

    This is a report of the development of four self-study units in physics for college nonscience majors. The topics of the units are Waves and Sound, The Radiant Energy of Sunlight, Infrared Radiation, and Acceleration. Each unit includes an inexpensive, portable kit; a student manual containing all requisite background information, self-test,…

  13. The AskA Starter Kit: How To Build and Maintain Digital Reference Services.

    ERIC Educational Resources Information Center

    Lankes, R. David; Kasowitz, Abby S.

    This Starter Kit is designed to help organizations and individuals who wish to offer human-mediated information services via the Internet to users in the K-12 community. A six-step process is proposed for organizations to follow in creating an "AskA" service. This process addresses all aspects involved in building and maintaining an AskA…

  14. Nonbibliographic Machine-Readable Data Bases in ARL Libraries. SPEC Kit 105.

    ERIC Educational Resources Information Center

    Westerman, Mel

    This document is one of ten kits distributed annually by the Systems and Procedures Exchange Center (SPEC), a clearinghouse operated by the Association of Research Libraries, Office of Management Studies (ARL/OMS) that provides a central source of timely information and materials on the management and operations of large academic and research…

  15. Shuttle orbiter TPS flight repair kit development

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The design and application of a TPS repair kit is presented. The repair kit is designed for on orbit use by a crew member working in the manned maneuvering unit (MMU). The kit includes the necessary equipment and materials to accomplish the repair tasks which include the following: HRSI emittance coating repair, damaged tile repair, missing tile repair, and multiple tile repair. Two types of repair materials required to do the small area repair and the large area repair are described. The materials area cure in place, silicone base ablator for small damaged areas and precured ablator tile for repair of larger damaged areas is examined. The cure in place ablator is also used as an adhesive to bond the precured tiles in place. An applicator for the cure in place ablator, designed to contain a two-part silicon compound, mix the two components at correct ratio, and dispense the materials at rates compatible with mission timelines established for the EVA is described.

  16. [Forensic application of investigator HDplex kit in Han nationality of Eastern China].

    PubMed

    Zhang, Su-hua; Zhang, Zhe-ren; Sun, Kuan; Zhao, Zhen-min; Li, Cheng-tao

    2012-10-01

    To investigate the genetic data of 12 autosomal STR loci included in Investigator HDplex kit and to evaluate its forensic application in Han nationality of Eastern China. A total of 484 unrelated healthy individuals in Han nationality of Eastern China were investigated with Investigator HDplex kit. Allele frequencies, population genetics parameters and linkage disequilibrium information of the 12 autosomal STR loci were statistically analyzed. No deviations from Hardy-Weinberg equilibrium were detected and all loci were independent form each other within the studied 484 unrelated healthy individuals. DP values of the 12 autosomal STR loci were all above 0.8, and CDP was 0.999 999 999 92. The cumulative probability of paternity exclusion in duo and in trio were 0.999 82 and 0.999 998 6, respectively. Investigator HDplex kit with 12 highly polymorphic STR loci in Han nationality of Eastern China could be used effectively for forensic DNA genotyping.

  17. Low cost alternatives to commercial lab kits for physics experiments

    NASA Astrophysics Data System (ADS)

    Kodejška, Č.; De Nunzio, G.; Kubínek, R.; Říha, J.

    2015-08-01

    Conducting experiments in physics using modern measuring techniques, and particularly those utilizing computers, is often much more attractive to students than conducting experiments conventionally. However, the cost of professional kits in the Czech Republic is still very expensive for many schools. The basic equipment for one student workplace in the case of professional kits such as Vernier, Pasco or Coach costs around 800 euros. In this paper some physics experiments in which a computer, or a tablet with Microsoft Windows, is used as the measuring device, along with available physical devices such as a laser pointer, a solar cell or an electret microphone, are presented as suitable and alternative ways to carry out lab work. We show that it is possible to perform very simple school experiments (both as a central demonstration and as individual experimentation), in which high accuracy and clear final conclusions can be achieved at a very low cost. Further information is published on the specialized webpage www.sclpx.eu/index.php?lang=en. The worksheets are in Czech, but the English version is in preparation.

  18. Reproductive health kits provided by UNFPA to Kosovar refugees.

    PubMed

    1999-06-01

    In addition to food, clothing, and shelter, the hundreds of thousands of refugees fleeing Kosovo need primary health care services, including reproductive health care. The United Nations Population Fund (UNFPA) estimates that of a population of 350,000 refugees in Albania, 35,000 are women in need of prenatal or postnatal care. According to UNFPA, 7 babies were born in 1 refugee camp alone in one 24-hour period, and there are widespread reports of the systematic rape of ethnic Albanian women as they flee. In response, UNFPA announced in early April that it is coordinating the delivery of emergency reproductive health kits to Albanian refugee camps. Each kit contains clean delivery supplies, emergency contraceptive pills (ECP) for women who have been raped, counseling information for post-rape trauma, supplies to treat the complications of unsafe abortion, and condoms, IUDs, and other contraceptive methods. UNFPA expects to send enough supplies to care for the refugees for up to 6 months, with most supplies aimed at providing safe deliveries. The Vatican immediately condemned UNFPA's distribution of ECPs. Whether the US will renew its funding of UNFPA is pending before Congress.

  19. A survival Kit for pancreatic beta cells: stem cell factor and c-Kit receptor tyrosine kinase.

    PubMed

    Feng, Zhi-Chao; Riopel, Matthew; Popell, Alex; Wang, Rennian

    2015-04-01

    The interactions between c-Kit and its ligand, stem cell factor (SCF), play an important role in haematopoiesis, pigmentation and gametogenesis. c-Kit is also found in the pancreas, and recent studies have revealed that c-Kit marks a subpopulation of highly proliferative pancreatic endocrine cells that may harbour islet precursors. c-Kit governs and maintains pancreatic endocrine cell maturation and function via multiple signalling pathways. In this review we address the importance of c-Kit signalling within the pancreas, including its profound role in islet morphogenesis, islet vascularisation, and beta cell survival and function. We also discuss the impact of c-Kit signalling in pancreatic disease and the use of c-Kit as a potential target for the development of cell-based and novel drug therapies in the treatment of diabetes.

  20. Megakaryocytes compensate for Kit insufficiency in murine arthritis

    PubMed Central

    Cunin, Pierre; Penke, Loka R.; Thon, Jonathan N.; Monach, Paul A.; Jones, Tatiana; Chang, Margaret H.; Chen, Mary M.; Melki, Imene; Gurish, Michael F.; Italiano, Joseph E.; Boilard, Eric; Nigrovic, Peter A.

    2017-01-01

    The growth factor receptor Kit is involved in hematopoietic and nonhematopoietic development. Mice bearing Kit defects lack mast cells; however, strains bearing different Kit alleles exhibit diverse phenotypes. Herein, we investigated factors underlying differential sensitivity to IgG-mediated arthritis in 2 mast cell–deficient murine lines: KitWsh/Wsh, which develops robust arthritis, and KitW/Wv, which does not. Reciprocal bone marrow transplantation between KitW/Wv and KitWsh/Wsh mice revealed that arthritis resistance reflects a hematopoietic defect in addition to mast cell deficiency. In KitW/Wv mice, restoration of susceptibility to IgG-mediated arthritis was neutrophil independent but required IL-1 and the platelet/megakaryocyte markers NF-E2 and glycoprotein VI. In KitW/Wv mice, platelets were present in numbers similar to those in WT animals and functionally intact, and transfer of WT platelets did not restore arthritis susceptibility. These data implicated a platelet-independent role for the megakaryocyte, a Kit-dependent lineage that is selectively deficient in KitW/Wv mice. Megakaryocytes secreted IL-1 directly and as a component of circulating microparticles, which activated synovial fibroblasts in an IL-1–dependent manner. Transfer of WT but not IL-1–deficient megakaryocytes restored arthritis susceptibility to KitW/Wv mice. These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1–driven systemic inflammatory disease. PMID:28375155

  1. Mountain medical kits: epidemiology-based recommendations and analysis of medical supplies carried by mountain climbers in Colorado.

    PubMed

    Brandenburg, William E; Locke, Brian W

    2017-03-01

    : To provide medical kit recommendations for short mountain wilderness recreation trips (hiking, trekking, backpacking, mountaineering etc.) based on the epidemiology of injury and illness sustained and best treatment guidelines. Additionally, to compare these recommendations to the medical kit contents of mountain climbers in Colorado. : A primary literature review concerning the epidemiology of injury and illness in mountain wilderness settings was performed. This information and literature on the efficacy of given treatments were used to derive recommendations for an evidence-based medical kit. The contents of 158 medical kits and the most likely demographics to carry them were compiled from surveys obtained from mountain climbers on 11 of Colorado's 14 000-foot peaks. : Musculoskeletal trauma, strains, sprains and skin wounds were the most common medical issues reported in the 11 studies, which met inclusion criteria. Adhesive bandages (Band-Aids) were the most common item and non-steroidal anti-inflammatory drugs were the most common medication carried in medical kits in Colorado. More than 100 distinct items were reported overall. : Mountain climbing epidemiology and current clinical guidelines suggest that a basic mountain medical kit should include items for body substance isolation, materials for immobilization, pain medications, wound care supplies, and medications for gastrointestinal upset and flu-like illness. The medical kits of Colorado mountain climbers varied considerable and often lacked essential items such as medical gloves. This suggests a need for increased guidance. Similar methodology could be used to inform medical kits for other outdoor activities, mountain rescue personnel, and travel to areas with limited formal medical care.

  2. Food kit used by Mercury astronauts

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Food kit used by Mercury astronauts. Some is dehydrated and needs water, other packets are ready to eat. Size is measured relative to a ruler. Included are packets of mushroom soup, orange-grapefruit juice, cocoa beverage, pineapple juice, chicken with gravy, pears, strawberries, beef and vegetables and other assorted food containers (08742-3); mechanism for connecting water dispensor to dehydrated food containers to facilitate rehydration (08744); Group packets of ready to eat space food, with size being measured by a ruler (8745).

  3. The Fluid Dynamics Demo Kit: Part II

    NASA Astrophysics Data System (ADS)

    Underhill, Patrick; Fix, Hannah; Haines, Timothy; Prestridge, Kathy; Flack, Karen

    2012-11-01

    This talk will focus on the current contents and efforts building a fluid dynamics demonstration/experiment kit through the APS-DFD Mentoring and Outreach Committee and with funding from the APS DFD. The current experiments include predicting how far the water from a water gun will go, predicting how long a Heron's fountain will run, measuring the viscosity of corn syrup by measuring terminal velocity, and measuring the flow rate through a siphon. We will discuss the testing and development of these experiments and the results of field testing. Ideas for future experiments will also be discussed.

  4. Food kit used by Mercury astronauts

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Food kit used by Mercury astronauts. Some is dehydrated and needs water, other packets are ready to eat. Size is measured relative to a ruler. Included are packets of mushroom soup, orange-grapefruit juice, cocoa beverage, pineapple juice, chicken with gravy, pears, strawberries, beef and vegetables and other assorted food containers (08742-3); mechanism for connecting water dispensor to dehydrated food containers to facilitate rehydration (08744); Group packets of ready to eat space food, with size being measured by a ruler (8745).

  5. Quantifiler® Trio Kit and forensic samples management: a matter of degradation.

    PubMed

    Vernarecci, Stefano; Ottaviani, Enrica; Agostino, Alessandro; Mei, Elisabetta; Calandro, Lisa; Montagna, Paola

    2015-05-01

    DNA collected from crime scenes may have experienced different levels of degradation. This is mainly due to sample exposure to different environmental factors. The impact of DNA degradation on short tandem repeat (STR) profiling can lead to partial or null information and in some cases, the identification of the trace may fail. The availability of a system enabling the assessment not only of the quantity of the DNA but also of its quality in terms of degradation would result in shorter time for sample processing, more reliable identifications and cost reduction by predicting the quality of the DNA profiles prior to STR analysis. We report here a study on 181 selected degraded DNA samples extracted from real crime scene evidence. The selected samples were processed by combining the use of a new commercial quantification kit (Quantifiler® Trio) with a new 24 marker multiplex PCR amplification kit (Globalfiler® Kit). Applying different statistical analyses we investigated the reliability of the Degradation Index provided by the Quantifiler® Trio in determining the level of DNA degradation in a forensic sample. This useful information can be used to predict the quality of the profile obtained after STR amplification. The combination of such a quantification kit with different PCR protocols allowed us to define practical guidelines for processing degraded forensic DNA samples with a simplified and comprehensive approach.

  6. Comparison of presumptive blood test kits including hexagon OBTI.

    PubMed

    Johnston, Emma; Ames, Carole E; Dagnall, Kathryn E; Foster, John; Daniel, Barbara E

    2008-05-01

    Four presumptive blood tests, Hexagon OBTI, Hemastix(R), Leucomalachite green (LMG), and Kastle-Meyer (KM) were compared for their sensitivity in the identification of dried bloodstains. Stains of varying blood dilutions were subjected to each presumptive test and the results compared. The Hexagon OBTI buffer volume was also reduced to ascertain whether this increased the sensitivity of the kit. The study found that Hemastix(R) was the most sensitive test for trace blood detection. Only with the reduced buffer volume was the Hexagon OBTI kit as sensitive as the LMG and KM tests. However, the Hexagon OBTI kit has the advantage of being a primate specific blood detection kit. This study also investigated whether the OBTI buffer within the kit could be utilized for DNA profiling after presumptive testing. The results show that DNA profiles can be obtained from the Hexagon OBTI kit buffer directly.

  7. To Kit or Not to Kit? Evaluating and Implementing Science Materials and Resources

    ERIC Educational Resources Information Center

    Schiller, Ellen; Melin, Jacque; Bair, Mary

    2016-01-01

    With the release of the "Next Generation Science Standards," many schools are reexamining the science materials they are using. Textbook companies and kit developers are eager to meet the demand for "NGSS"-aligned teaching materials. Teacher may have been asked to serve on a science curriculum committee, or to evaluate current…

  8. Selling Addiction: A Workshop Kit on Tobacco and Alcohol Advertising. A Media Literacy Workshop Kit.

    ERIC Educational Resources Information Center

    Barnes, Mary Ellen; And Others

    This kit consists of: (1) a leader's guide; (2) an 18-minute videotape containing three 6-minute discussion starter segments analyzing typical commercials and advertising techniques; (3) a special issue of "Media Values" magazine on the theme "Fatal Attraction: The Selling of Addiction"; (4) an 8-page booklet "Awareness to Action: Media Literacy…

  9. Selling Addiction: A Workshop Kit on Tobacco and Alcohol Advertising. A Media Literacy Workshop Kit.

    ERIC Educational Resources Information Center

    Barnes, Mary Ellen; And Others

    This kit consists of: (1) a leader's guide; (2) an 18-minute videotape containing three 6-minute discussion starter segments analyzing typical commercials and advertising techniques; (3) a special issue of "Media Values" magazine on the theme "Fatal Attraction: The Selling of Addiction"; (4) an 8-page booklet "Awareness to Action: Media Literacy…

  10. To Kit or Not to Kit? Evaluating and Implementing Science Materials and Resources

    ERIC Educational Resources Information Center

    Schiller, Ellen; Melin, Jacque; Bair, Mary

    2016-01-01

    With the release of the "Next Generation Science Standards," many schools are reexamining the science materials they are using. Textbook companies and kit developers are eager to meet the demand for "NGSS"-aligned teaching materials. Teacher may have been asked to serve on a science curriculum committee, or to evaluate current…

  11. Pathologic and physiologic phimosis

    PubMed Central

    McGregor, Thomas B.; Pike, John G.; Leonard, Michael P.

    2007-01-01

    OBJECTIVE To review the differences between physiologic and pathologic phimosis, review proper foreskin care, and discuss when it is appropriate to seek consultation regarding a phimotic foreskin. SOURCES OF INFORMATION This paper is based on selected findings from a MEDLINE search for literature on phimosis and circumcision referrals and on our experience at the Children’s Hospital of Eastern Ontario Urology Clinic. MeSH headings used in our MEDLINE search included “phimosis,” “referral and consultation,” and “circumcision.” Most of the available articles about phimosis and foreskin referrals were retrospective reviews and cohort studies (levels II and III evidence). MAIN MESSAGE Phimosis is defined as the inability to retract the foreskin. Differentiating between physiologic and pathologic phimosis is important, as the former is managed conservatively and the latter requires surgical intervention. Great anxiety exists among patients and parentsregarding non-retractile foreskins. Most phimosis referrals seen in pediatric urology clinics are normal physiologically phimotic foreskins. Referrals of patients with physiologic phimosis to urology clinics can create anxiety about the need for surgery among patients and parents, while unnecessarily expanding the waiting list for specialty assessment. Uncircumcised penises require no special care. With normal washing, using soap and water, and gentle retraction during urination and bathing, most foreskins will become retractile over time. CONCLUSION Physiologic phimosis is often seen by family physicians. These patients and their parents require reassurance of normalcy and reinforcement of proper preputial hygiene. Consultation should be sought when evidence of pathologic phimosis is present, as this requires surgical management. PMID:17872680

  12. Android: Call C Functions with the Native Development Kit (NDK)

    DTIC Science & Technology

    2016-09-01

    ARL-TN-0782 ● SEP 2016 US Army Research Laboratory Android: Call C Functions with the Native Development Kit (NDK) by Hao Q...from a Java application. 15. SUBJECT TERMS Android, NDK, Native Development Kit , C callable, Java Native Interface, JNI, Java, C / C ++ 16. SECURITY...Development Kit (NDK) and the Java Native Interface (JNI) provides such a mechanism. NDK is a toolset that allows users to build C / C ++ functions

  13. Data Center Energy Efficiency Measurement Assessment Kit Guide and Specification

    SciTech Connect

    2012-10-26

    A portable and temporary wireless mesh assessment kit can be used to speed up and reduce the costs of a data center energy use assessment and overcome the issues with respect to shutdowns. The assessment kit is comprised of temperature, relative humidity, and pressure sensors. Also included are power meters that can be installed on computer room air conditioners (CRACs) without intrusive interruption of data center operations. The assessment kit produces data required for a detailed energy assessment of the data center.

  14. [Real-time PCR kits for the detection of the African Swine Fever virus].

    PubMed

    Latyshev, O E; Eliseeva, O V; Grebennikova, T V; Verkhovskiĭ, O A; Tsibezov, V V; Chernykh, O Iu; Dzhailidi, G A; Aliper, T I

    2014-01-01

    The results obtained using the diagnostic kit based on real-time polymerase chain reaction to detect the DNA of the African Swine Fever in the pathological material, as well as in the culture fluid, are presented. A high sensitivity and specificity for detection of the DNA in the organs and tissues of animals was shown to be useful for detection in the European Union referentiality reagent kits for DNA detection by real time PCR of ASFV. More rapid and effective method of DNA extraction using columns mini spin Quick gDNA(TM) MiniPrep was suggested and compared to the method of DNA isolation on the inorganic sorbent. High correlation of the results of the DNA detection of ASFV by real-time PCR and antigen detection results ASFV by competitive ELISA obtained with the ELISA SEROTEST/INGEZIM COMRAC PPA was demonstrated. The kit can be used in the veterinary services for effective monitoring of ASFV to contain, eliminate and prevent further spread of the disease.

  15. Mast cells rescue implantation defects caused by c-kit deficiency

    PubMed Central

    Woidacki, K; Popovic, M; Metz, M; Schumacher, A; Linzke, N; Teles, A; Poirier, F; Fest, S; Jensen, F; Rabinovich, G A; Maurer, M; Zenclussen, A C

    2013-01-01

    Various physiologically relevant processes are regulated by the interaction of the receptor tyrosine kinase (c-Kit) and its ligand stem cell factor (SCF), with SCF known to be the most important growth factor for mast cells (MCs). In spite of their traditional role in allergic disorders and innate immunity, MCs have lately emerged as versatile modulators of a variety of physiologic and pathologic processes. Here we show that MCs are critical for pregnancy success. Uterine MCs presented a unique phenotype, accumulated during receptivity and expanded upon pregnancy establishment. KitW-sh/W-sh mice, whose MC deficiency is based on restricted c-Kit gene expression, exhibited severely impaired implantation, which could be completely rescued by systemic or local transfer of wild-type bone marrow-derived MCs. Transferred wild-type MCs favored normal implantation, induced optimal spiral artery remodeling and promoted the expression of MC proteases, transforming growth factor-β and connective tissue growth factor. MCs contributed to trophoblast survival, placentation and fetal growth through secretion of the glycan-binding protein galectin-1. Our data unveil unrecognized roles for MCs at the fetomaternal interface with critical implications in reproductive medicine. PMID:23328669

  16. Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition

    PubMed Central

    Carvajal, Richard D.; Lawrence, Donald P.; Weber, Jeffrey S.; Gajewski, Thomas F.; Gonzalez, Rene; Lutzky, Jose; O’Day, Steven J.; Hamid, Omid; Wolchok, Jedd D.; Chapman, Paul B.; Sullivan, Ryan J.; Teitcher, Jerrold B.; Ramaiya, Nikhil; Giobbie-Hurder, Anita; Antonescu, Cristina R.; Heinrich, Michael C.; Bastian, Boris C.; Corless, Christopher L.; Fletcher, Jonathan A.; Hodi, F. Stephen

    2016-01-01

    Purpose Although durable responses can be achieved with tyrosine kinase inhibitors such as imatinib in melanomas harboring KIT mutations, the efficacy of alternative inhibitors after progression to imatinib and the activity of these agents on brain metastases is unknown. Experimental Design We conducted a phase II study of nilotinib 400 mg BID in two cohorts of patients with melanomas harboring KIT mutations or amplification: A) those refractory or intolerant to a prior KIT inhibitor; and B) those with brain metastases. The primary endpoint was 4-month disease control rate. Secondary endpoints included response rate, time-to-progression and overall survival. A Simon two-stage and a single-stage design was planned to assess for the primary endpoint in Cohorts A and B, respectively. Results Twenty patients were enrolled and 19 treated (11-Cohort A; 8-Cohort B). Three patients on Cohort A (27%; 95% CI, 8% – 56%) and 1 on Cohort B (12.5%; 90% CI, 0.6% – 47%) achieved the primary endpoint. Two partial responses were observed in Cohort A (18.2%, 90% CI, 3% – 47%); none were observed in Cohort B. The median time-to-progression and overall survival was 3·3 (90% CI, 2.1 – 3.9 months) and 9.1 months (90% CI, 4.3 – 14.2 months), respectively, in all treated patients. Conclusion Nilotinib may achieve disease control in patients with melanoma harboring KIT alterations and whose disease progressed after imatinib therapy. The efficacy of this agent in KIT altered melanoma with brain metastasis is limited. PMID:25695690

  17. Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition.

    PubMed

    Carvajal, Richard D; Lawrence, Donald P; Weber, Jeffrey S; Gajewski, Thomas F; Gonzalez, Rene; Lutzky, Jose; O'Day, Steven J; Hamid, Omid; Wolchok, Jedd D; Chapman, Paul B; Sullivan, Ryan J; Teitcher, Jerrold B; Ramaiya, Nikhil; Giobbie-Hurder, Anita; Antonescu, Cristina R; Heinrich, Michael C; Bastian, Boris C; Corless, Christopher L; Fletcher, Jonathan A; Hodi, F Stephen

    2015-05-15

    Although durable responses can be achieved with tyrosine kinase inhibitors such as imatinib in melanomas harboring KIT mutations, the efficacy of alternative inhibitors after progression to imatinib and the activity of these agents on brain metastases are unknown. We conducted a phase II study of nilotinib 400 mg twice a day in two cohorts of patients with melanomas harboring KIT mutations or amplification: (A) those refractory or intolerant to a prior KIT inhibitor; and (B) those with brain metastases. The primary endpoint was 4-month disease control rate. Secondary endpoints included response rate, time-to-progression (TTP), and overall survival (OS). A Simon two-stage and a single-stage design was planned to assess for the primary endpoint in cohorts A and B, respectively. Twenty patients were enrolled and 19 treated (11 in cohort A; 8 in cohort B). Three patients on cohort A [27%; 95% confidence interval (CI), 8%-56%] and 1 on cohort B (12.5%; 90% CI, 0.6%-47%) achieved the primary endpoint. Two partial responses were observed in cohort A (18.2%; 90% CI, 3%-47%); none were observed in cohort B. The median TTP and OS was 3.3 (90% CI, 2.1-3.9 months) and 9.1 months (90% CI, 4.3-14.2 months), respectively, in all treated patients. Nilotinib may achieve disease control in patients with melanoma harboring KIT alterations and whose disease progressed after imatinib therapy. The efficacy of this agent in KIT-altered melanoma with brain metastasis is limited. ©2015 American Association for Cancer Research.

  18. c-Kit signaling determines neointimal hyperplasia in arteriovenous fistulae.

    PubMed

    Skartsis, Nikolaos; Martinez, Laisel; Duque, Juan Camilo; Tabbara, Marwan; Velazquez, Omaida C; Asif, Arif; Andreopoulos, Fotios; Salman, Loay H; Vazquez-Padron, Roberto I

    2014-11-01

    Stenosis of arteriovenous (A-V) fistulae secondary to neointimal hyperplasia (NIH) compromises dialysis delivery, which worsens patients' quality of life and increases medical costs associated with the maintenance of vascular accesses. In the present study, we evaluated the role of the receptor tyrosine kinase c-Kit in A-V fistula neointima formation. Initially, c-Kit was found in the neointima and adventitia of human brachiobasilic fistulae, whereas it was barely detectable in control veins harvested at the time of access creation. Using the rat A-V fistula model to study venous vascular remodeling, we analyzed the spatial and temporal pattern of c-Kit expression in the fistula wall. Interestingly, c-Kit immunoreactivity increased with time after anastomosis, which concurred with the accumulation of cells in the venous intima. In addition, c-Kit expression in A-V fistulae was positively altered by chronic kidney failure conditions. Both blockade of c-Kit with imatinib mesylate (Gleevec) and inhibition of stem cell factor production with a specific short hairpin RNA prevented NIH in the outflow vein of experimental fistulae. In agreement with these data, impaired c-Kit activity compromised the development of NIH in A-V fistulae created in c-KitW/Wv mutant mice. These results suggest that targeting of the c-Kit signaling pathway may be an effective approach to prevent postoperative NIH in A-V fistulae.

  19. c-Kit signaling determines neointimal hyperplasia in arteriovenous fistulae

    PubMed Central

    Skartsis, Nikolaos; Martinez, Laisel; Duque, Juan Camilo; Tabbara, Marwan; Velazquez, Omaida C.; Asif, Arif; Andreopoulos, Fotios; Salman, Loay H.

    2014-01-01

    Stenosis of arteriovenous (A-V) fistulae secondary to neointimal hyperplasia (NIH) compromises dialysis delivery, which worsens patients' quality of life and increases medical costs associated with the maintenance of vascular accesses. In the present study, we evaluated the role of the receptor tyrosine kinase c-Kit in A-V fistula neointima formation. Initially, c-Kit was found in the neointima and adventitia of human brachiobasilic fistulae, whereas it was barely detectable in control veins harvested at the time of access creation. Using the rat A-V fistula model to study venous vascular remodeling, we analyzed the spatial and temporal pattern of c-Kit expression in the fistula wall. Interestingly, c-Kit immunoreactivity increased with time after anastomosis, which concurred with the accumulation of cells in the venous intima. In addition, c-Kit expression in A-V fistulae was positively altered by chronic kidney failure conditions. Both blockade of c-Kit with imatinib mesylate (Gleevec) and inhibition of stem cell factor production with a specific short hairpin RNA prevented NIH in the outflow vein of experimental fistulae. In agreement with these data, impaired c-Kit activity compromised the development of NIH in A-V fistulae created in c-KitW/Wv mutant mice. These results suggest that targeting of the c-Kit signaling pathway may be an effective approach to prevent postoperative NIH in A-V fistulae. PMID:25186298

  20. Prognostic value of KIT/PDGFRA mutations in gastrointestinal stromal tumors: a meta-analysis

    PubMed Central

    2014-01-01

    Background The postulated relationship between KIT/PDGFRA mutations and their prognostic value in gastrointestinal stromal tumors (GISTs) has generated intense attention during the past decade, despite the fact that a great deal of studies have been conducted on this subject. To provide a strong quantitative estimate of this postulated relationship, we carried out a meta-analysis which combined, compared, and summarized the results of existing relevant studies. Methods Studies were identified by searching databases and reviewing citations in relevant articles. Of 48 potentially relevant studies, we combined individual patient data from 18 studies which involved 1,487 patients with GISTs, by which we made a comparison between the positive KIT mutation subgroup and the negative KIT mutation subgroup (PDGFRA mutation and wild type). We tabulated and analyzed the patient characteristics from each study, including general information such as age and gender, histopathological parameters, and clinical follow-up outcomes. Results KIT mutations, compared with PDGFRA mutations and wild type, showed a marked increased risk not only for tumor size (>5 cm) but also for higher mitotic activity (>5), suggesting that KIT mutations significantly correlated with the National Comprehensive Cancer Network (NCCN) high risk or National Institutes of Health (NIH) high risk (1.74 (95% CI, 1.20 to 2.53) and 2.00 (95% CI, 1.08 to 3.68), respectively). Moreover, higher recurrence and metastasis was observed in GISTs with KIT mutations, revealing its closer correlation with clinical malignant risk (P <0.001 for each, with odds ratio (OR) of 2.06 (95%, 1.37 to 3.11) and 2.77 (95%, 1.64 to 4.67), respectively). High risk or malignant GISTs with KIT mutations had a significantly poorer prognosis, as measured by 3-year overall survival, compared to those with PDGFRA mutations and wild type (0.47 (95% CI, 0.25 to 0.90)). Conclusions KIT mutations, compared with PDGFRA mutations and wild type

  1. [Application of the QIAamp DNA Investigator Kit and Prepfiler Forensic DNA Extraction Kit in genomic DNA extraction from skeletal remains].

    PubMed

    Ludwikowska-Pawłowska, Małgorzata; Jacewicz, Renata; Jedrzejczyk, Maciej; Prośniak, Adam; Berent, Jarosław

    2009-01-01

    The report presents an application of the QIAamp DNA Investigator Kit and PrepFiler Forensic DNA Extraction Kit in genomic DNA extraction from post-mortem highly degraded skeletal remains. The analysis included 25 bone samples collected on autopsy. DNA extraction was performed in accordance with the QIAamp DNA Investigator Kit and PrepFiler Forensic DNA Extraction Kit manufacturer's isolation protocols. Amplification was performed on a Biometra termocycler using the AmpFISTR Identifiler PCR Amplification Kit according to the manufacturer's protocol. Typing of PCR products was carried out on an ABI Prism 377 DNA sequencer. The recommended parameters for GeneScan analysis and Genotyper software were followed. The authors demonstrated that the QIAamp DNA Investigator Kit was more effective, convenient and statistically significantly better method which may be employed in DNA extraction from bone specimens.

  2. Fleas of the San Joaquin kit fox (Vulpes velox macrotis) on Camp Roberts Army National Guard Training Site, California

    SciTech Connect

    Spencer, K.A.; Egoscue, H.J.

    1992-09-01

    A total of 3,241 fleas, representing seven species, were identified from 398 samples collected from San Joaquin kit foxes (Vulpes velox macrotis), California ground squirrels (Spermophilus beecheyi), and deer mice (Peromyscus maniculatus) at Camp Roberts Army National Guard Training Site, California, from November 1988 through September 1991. Of 3,109 fleas collected from kit foxes 95.7% were Echidnophaga gallinacea, 4.0% Pulex irritans, 0.2% Hoplopsyllus anomolus, and 0.1% Odontopsyllus dentatus. One male Ctenocephalides fells was also collected from a kit fox. The 118 fleas collected from California ground squirrels consisted of Hoplopsyllus anomolus (55.9%), Echidnophaga gallinacea (37.3%), and Oropsylla montanus (6.8%). The 14 fleas collected from deer mice were Aetheca wagneri. Based on the distribution and abundance of flea species collected, and the vector efficiency of these fleas, it appears that kit foxes could play a role in the transfer of natural vectors of sylvatic plague between rodent populations, if the bacterium responsible for plague (Yersinia pestis) were present at Camp Roberts. Little information regarding kit fox food habits was evidenced by the distribution and abundance of small mammal flea species collected from kit foxes.

  3. Application of traditional clinical pathology quality control techniques to molecular pathology.

    PubMed

    Liang, Shu-Ling; Lin, Ming-Tseh; Hafez, Michael J; Gocke, Christopher D; Murphy, Kathleen M; Sokoll, Lori J; Eshleman, James R

    2008-03-01

    Many molecular diagnostic laboratories have evolved from research laboratories, initially performing low numbers of homebrew assays, but many laboratories now perform more kit-based assays, with ever increasing test volumes. One such assay is assessment of bone marrow transplantation engraftment. Allogeneic bone marrow transplantation is performed primarily in the treatment of hematological malignancies. Monitoring of engraftment was traditionally evaluated using minisatellites (variable number tandem repeats) and Southern blotting, but most laboratories now use Food and Drug Administration-cleared microsatellite (short tandem repeats) kits to assess the extent of engraftment. With the increase in equipment reliability, the use of kit-based assays, and the desire to provide the highest quality clinical data, we began applying traditional clinical pathology quality control tools to the molecular diagnostics laboratory. In this study, we demonstrate this approach using a microsatellite-based bone marrow engraftment assay. We analyzed control samples (pure and mixed) for two different microsatellites to establish quality control parameters and constructed Levey-Jennings charts to monitor both the precision and accuracy of this assay. By incorporating these tools into an overall quality assurance program, a laboratory can identify systematic errors and perform corrective actions before actual assay failure, thereby improving the quality of patient care.

  4. Nationwide study of factors associated with public's willingness to use home self-test kit for dengue fever in Malaysia.

    PubMed

    Wong, Li Ping; Atefi, Narges; AbuBakar, Sazaly

    2016-08-12

    dengue fever knowledge score (range 23-44). With response to characteristics of the test kit, participants indicated that ease of usability and easy to understand instructions were the most important factors influencing the decision to use the dengue home test kit; this was followed by the price of the test kit. The study highlights the need for provision of information to increase knowledge about the home self-testing dengue kit. Educational interventions should target people with low educational levels, those with lower dengue fever knowledge and those with lower perceived barriers to dengue prevention.

  5. Resveratrol improves smooth muscle carcinogenesis in the progression of chronic prostatitis via the downregulation of c-kit/SCF by activating Sirt1.

    PubMed

    He, Yi; Zeng, Huizhi; Yu, Yang; Zhang, Jiashu; Duan, Xingping; Liu, Qi; Yang, Bo

    2017-08-22

    Bladder smooth muscle cell death accompanied by hyperplasia and hypertrophy, as induced by inflammation, is the primary cause for poor bladder function. There are emerging evidences on the role of chronic inflammation as a factor involved in carcinogenesis and progression. We aim to determine the bladder smooth muscle pathological changes and dysfunction in chronic prostatitis (CP), to investigate whether resveratrol can improve the urinary dysfunction and the role of c-kit/SCF pathway, that has been associated with the smooth muscle carcinogenesis. Rat model of CP was established via subcutaneous injections of DPT vaccine and subsequently treated with resveratrol. H&E staining was performed to identify the histopathological changes in prostates and bladders. Western blotting and immunohistochemical staining examined the expression level of C-kit, stem cell factor (SCF), Sirt1, apoptosis associated proteins. the model group exhibited severe diffuse chronic inflammation, characterized by leukocyte infiltration and papillary frond protrusion into the gland cavities, and a notable increase in prostatic epithelial height. Meanwhile, bladder muscle arranged in disorder with fracture, and cells appeared atypia. The activity of C-kit/SCF was up-regulated, the carcinogenesis associated proteins are dysregulated significantly in CP rats. Resveratrol treatment significantly improved these factors by Sirt1 activation. activated c-kit/SCF and bladder muscle carcinogenesis were involved in the pathological processes of CP, which was improved after resveratrol treatment via the downregulation of c-kit/SCF by activating Sirt1. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  6. Updates of pathologic myopia.

    PubMed

    Ohno-Matsui, Kyoko; Lai, Timothy Y Y; Lai, Chi-Chun; Cheung, Chiu Ming Gemmy

    2016-05-01

    Complications from pathologic myopia are a major cause of visual impairment and blindness, especially in east Asia. The eyes with pathologic myopia may develop loss of the best-corrected vision due to various pathologies in the macula, peripheral retina and the optic nerve. Despite its importance, the definition of pathologic myopia has been inconsistent. The refractive error or axial length alone often does not adequately reflect the 'pathologic myopia'. Posterior staphyloma, which is a hallmark lesion of pathologic myopia, can occur also in non-highly myopic eyes. Recently a revised classification system for myopic maculopathy has been proposed to standardize the definition among epidemiological studies. In this META-PM (meta analyses of pathologic myopia) study classification, pathologic myopia was defined as the eyes having chorioretinal atrophy equal to or more severe than diffuse atrophy. In addition, the advent of new imaging technologies such as optical coherence tomography (OCT) and three dimensional magnetic resonance imaging (3D MRI) has enabled the detailed observation of various pathologies specific to pathologic myopia. New therapeutic approaches including intravitreal injections of anti-vascular endothelial growth factor agents and the advance of vitreoretinal surgeries have greatly improved the prognosis of patients with pathologic myopia. The purpose of this review article is to provide an update on topics related to the field of pathologic myopia, and to outline the remaining issues which need to be solved in the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Validation of a commercial canine assay kit to measure pinniped cytokines.

    PubMed

    Levin, Milton; Romano, Tracy; Matassa, Keith; De Guise, Sylvain

    2014-07-15

    The present study was conducted to assess and validate the cross-reactivity of commercially available multiplex human and canine cytokine kits coupled with the Bio-Plex 200 platform to measure cytokines in three pinniped species, harbor seals (Phoca vitulina), gray seals (Halichoerus grypus), and harp seals (Pagophilus groenlandicus). Cytokines are important small proteins that help direct a proper immune response to pathogens. The human cytokine kit allowed the detection of cytokines in the supernatant of mitogen-stimulated human peripheral blood mononuclear cells, but not in the three pinniped species studied, with the exception of TNFα and GM-CSF. In contrast, the canine cytokine kit appeared to cross-react with the majority of cytokines in the three pinniped species tested, including the pro-inflammatory cytokine TNFα, the Th1 cytokine INFγ, and the Th2 cytokine IL-10, an anti-inflammatory cytokine. In addition, the pro-inflammatory cytokines IL-6 and IL-8 were also measured in all pinniped species. Overall, the Bio-Plex 200 platform and the canine multiplex cytokine kit allowed the successful measurement of potentially clinically important pinniped cytokines. This additional tool may provide veterinarians with additional information to detect sub-clinical signs of inflammation or evidence for immune response, which may not be revealed during regular medical evaluation, e.g. physical examination, hematology, and serum chemistry.

  8. Habitat evaluation using GIS a case study applied to the San Joaquin Kit Fox

    USGS Publications Warehouse

    Gerrard, R.; Stine, P.; Church, R.; Gilpin, M.

    2001-01-01

    Concern over the fate of plant and animal species throughout the world has accelerated over recent decades. Habitat loss is considered the main culprit in reducing many species' abundance and range, leading to numerous efforts to plan and manage habitat preservation. Our work uses Geographic Information Systems (GIS) data and modeling to define a spatially explicit analysis of habitat value, using the San Joaquin Kit Fox (Vulpes macrotis mutica) of California (USA) as an example. Over the last 30 years, many field studies and surveys have enhanced our knowledge of the life history, behavior, and needs of the kit fox, which has been proposed as an umbrella or indicator species for grassland habitat in the San Joaquin Valley of California. There has yet been no attempt to convert much of this field knowledge into a model of spatial habitat value useful for planning purposes. This is a significant omission given the importance and visibility of the imperiled kit fox and increasing trends toward spatially explicit modeling and planning. In this paper we apply data from northern California to derive a small-cell GIS raster of habitat value for the kit fox that incorporates both intrinsic habitat quality and neighborhood context, as well the effects of barriers such as roads. Such a product is a useful basis for assessing the presence and amounts of good (and poor) quality habitat and for eventually constructing GIS representations of viable animal territories that could be included in future reserves. ?? 2001 Elsevier Science B.V.

  9. Optimising the diagnostic strategy for onychomycosis from sample collection to FUNGAL identification evaluation of a diagnostic kit for real-time PCR.

    PubMed

    Petinataud, Dimitri; Berger, Sibel; Ferdynus, Cyril; Debourgogne, Anne; Contet-Audonneau, Nelly; Machouart, Marie

    2016-05-01

    Onychomycosis is a common nail disorder mainly due to dermatophytes for which the conventional diagnosis requires direct microscopic observation and culture of a biological sample. Nevertheless, antifungal treatments are commonly prescribed without a mycological examination having been performed, partly because of the slow growth of dermatophytes. Therefore, molecular biology has been applied to this pathology, to support a quick and accurate distinction between onychomycosis and other nail damage. Commercial kits are now available from several companies for improving traditional microbiological diagnosis. In this paper, we present the first evaluation of the real-time PCR kit marketed by Bio Evolution for the diagnosis of dermatophytosis. Secondly, we compare the efficacy of the kit on optimal and non-optimal samples. This study was conducted on 180 nails samples, processed by conventional methods and retrospectively analysed using this kit. According to our results, this molecular kit has shown high specificity and sensitivity in detecting dermatophytes, regardless of sample quality. On the other hand, and as expected, optimal samples allowed the identification of a higher number of dermatophytes by conventional mycological diagnosis, compared to non-optimal samples. Finally, we have suggested several strategies for the practical use of such a kit in a medical laboratory for quick pathogen detection.

  10. 21 CFR 872.3570 - OTC denture repair kit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false OTC denture repair kit. 872.3570 Section 872.3570 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3570 OTC denture repair kit. (a)...

  11. 21 CFR 872.3570 - OTC denture repair kit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false OTC denture repair kit. 872.3570 Section 872.3570 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3570 OTC denture repair kit. (a)...

  12. 21 CFR 872.3570 - OTC denture repair kit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false OTC denture repair kit. 872.3570 Section 872.3570 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3570 OTC denture repair kit. (a)...

  13. 21 CFR 872.3570 - OTC denture repair kit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false OTC denture repair kit. 872.3570 Section 872.3570 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES DENTAL DEVICES Prosthetic Devices § 872.3570 OTC denture repair kit. (a)...

  14. Indoor Air Quality Tools for Schools Action Kit. Second Edition.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This kit contains materials to assist a school indoor air quality (IAQ) coordinator in conducting a school IAQ program. The kit contains the following: IAQ coordinator's guide; IAQ coordinator forms; IAQ backgrounder; teacher's classroom checklist; administrative staff checklist; health officer/school nurse checklist; ventilation checklist and…

  15. Energy Education Incentives: Evaluating the Impact of Consumer Energy Kits

    ERIC Educational Resources Information Center

    Kirby, Sarah D.; Guin, Autumn; Langham, Laura

    2015-01-01

    Measuring the energy and environmental impact of residential energy education efforts is difficult. The E-Conservation residential energy management program uses consumer energy kits to document the impact of energy-efficient improvements. The consumer energy kit provides an incentive for individuals attending energy education workshop, helps…

  16. TQAP for Verification of Qualitative Lead Test Kits

    EPA Science Inventory

    There are lead-based paint test kits available to help home owners and contractors identify lead-based paint hazards before any Renovation, Repair, and Painting (RRP) activities take place so that proper health and safety meaures can be enacted. However, many of these test kits ...

  17. 14 CFR 1214.604 - Personal Preference Kit (PPK).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Personal Preference Kit (PPK). 1214.604... Aboard Space Shuttle Flights § 1214.604 Personal Preference Kit (PPK). (a) Purpose. The PPK enables... only by the Associate Administrator for Space Flight. (c) Approval of Contents. At least 60 days...

  18. 14 CFR 1214.603 - Official Flight Kit (OFK).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Official Flight Kit (OFK). 1214.603 Section... Aboard Space Shuttle Flights § 1214.603 Official Flight Kit (OFK). (a) Purpose. The OFK on a particular... addition to § 1214.602(c) of this part, U.S. national flags will not be flown as mementos except by...

  19. 14 CFR 1214.604 - Personal Preference Kit (PPK).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Personal Preference Kit (PPK). 1214.604... Aboard Space Shuttle Flights § 1214.604 Personal Preference Kit (PPK). (a) Purpose. The PPK enables... only by the Associate Administrator for Space Flight. (c) Approval of Contents. At least 60 days...

  20. 14 CFR § 1214.604 - Personal Preference Kit (PPK).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Personal Preference Kit (PPK). § 1214.604... Mementos Aboard Space Shuttle Flights § 1214.604 Personal Preference Kit (PPK). (a) Purpose. The PPK... only by the Associate Administrator for Space Flight. (c) Approval of Contents. At least 60 days...

  1. 14 CFR 1214.603 - Official Flight Kit (OFK).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Official Flight Kit (OFK). 1214.603 Section... Aboard Space Shuttle Flights § 1214.603 Official Flight Kit (OFK). (a) Purpose. The OFK on a particular... addition to § 1214.602(c) of this part, U.S. national flags will not be flown as mementos except by...

  2. 10 CFR 429.33 - Ceiling fan light kits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Ceiling fan light kits. 429.33 Section 429.33 Energy... COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.33 Ceiling fan light kits. (a) Sampling plan for selection of units for testing. (1) The requirements of § 429.11 are applicable to ceiling fan light...

  3. 10 CFR 429.33 - Ceiling fan light kits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Ceiling fan light kits. 429.33 Section 429.33 Energy... COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.33 Ceiling fan light kits. (a) Sampling plan for selection of units for testing. (1) The requirements of § 429.11 are applicable to ceiling fan light...

  4. 10 CFR 429.33 - Ceiling fan light kits.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Ceiling fan light kits. 429.33 Section 429.33 Energy... COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.33 Ceiling fan light kits. (a) Sampling plan for selection of units for testing. (1) The requirements of § 429.11 are applicable to ceiling fan light...

  5. Reengaging Disconnected Youth. Action Kit for Municipal Leaders. Issue #7

    ERIC Educational Resources Information Center

    Johnson, Alicia

    2005-01-01

    This action kit highlights steps city officials can take to help young people who are not connected to school, work, or caring adults. The kit recommends steps that cities can take to promote educational achievement, develop stronger workforce connections, support youth in transition from the foster care and juvenile justice systems, and build a…

  6. Computer-Based Assessment of Cognition: The ETS Factor Kit.

    ERIC Educational Resources Information Center

    Ekstrom, Ruth B.; Bejar, Isaac I.

    The history of the Educational Testing Service (ETS) Factor Kits is summarized. The original ETS Factor Kit was developed in 1954 and contained 51 items, three each for each of 15 factors and six for a 16th factor. The next edition was developed in 1963 and included adaptations (clones) of the defining tests instead of the exact copies. These…

  7. 33 CFR 144.01-30 - First-aid kit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false First-aid kit. 144.01-30 Section 144.01-30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES LIFESAVING APPLIANCES Manned Platforms § 144.01-30 First-aid kit....

  8. School-to-Work Jump-Start Equity Kit.

    ERIC Educational Resources Information Center

    Education Development Center, Inc., Newton, MA. Women's Educational Equity Act Dissemination Center.

    This starter kit is a resource for state and local school-to-work (STW) directors, educators, parents, students, business and community, and economic development organizations serving all students through STW. The kit begins with four articles: "STW and Gender Equity: Opportunity for or Barrier to Economic Parity?" (Katherine Hanson, Joyce…

  9. Take Two People--A Genetics Teaching Kit.

    ERIC Educational Resources Information Center

    Dixon, Rosy

    1982-01-01

    "Take Two People" is a kit of model genes which can be made up in packs to represent people or gametes. The kit is simple to make and highly adaptable. It has been useful and effective in teaching genetics to students of low ability and little motivation. (Author/JN)

  10. 14 CFR 1214.603 - Official Flight Kit (OFK).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Official Flight Kit (OFK). 1214.603 Section 1214.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Mementos Aboard Space Shuttle Flights § 1214.603 Official Flight Kit (OFK). (a) Purpose. The OFK on a...

  11. 14 CFR 1214.603 - Official Flight Kit (OFK).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Official Flight Kit (OFK). 1214.603 Section 1214.603 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Mementos Aboard Space Shuttle Flights § 1214.603 Official Flight Kit (OFK). (a) Purpose. The OFK on a...

  12. On-Line Bibliographic Search Services. SPEC Kit 62.

    ERIC Educational Resources Information Center

    Association of Research Libraries, Washington, DC. Office of Management Studies.

    This Systems and Procedures Exchange Center (SPEC) kit examines the current state of online services based upon the experiences of a select number of Association of Research Libraries (ARL) member libraries in the United States and Canada. Many of the kit documents were obtained during a survey of eight private institutions conducted for Duke…

  13. Neutral Buoyancy Simulator - Fluid line repair kit development

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Marshall's Neutral Buoyancy Simulator (NBS) is used to simulate the gravitational fields and buoyancy effects outer space has on astronauts and their ability to perform tasks in this environment. In this example, a diver performs a temporary fluid line repair task using a repair kit developed by Marshall engineers. The analysis will determine the value of this repair kit and its feasibility.

  14. A Survival Kit for Teaching English to Refugees. TECHNIQUES.

    ERIC Educational Resources Information Center

    Overbeck, Carla

    1984-01-01

    Adult basic education and English as a second language teachers, as well as volunteer tutors, can help new refugees acquire functional English through the use of a survival kit. The Literacy Volunteers of America's guide to teaching conversational English recommends these items for a survival kit: a written copy of student's name, address, and…

  15. TQAP for Verification of Qualitative Lead Test Kits

    EPA Science Inventory

    There are lead-based paint test kits available to help home owners and contractors identify lead-based paint hazards before any Renovation, Repair, and Painting (RRP) activities take place so that proper health and safety meaures can be enacted. However, many of these test kits ...

  16. Crystal Model Kits for Use in the General Chemistry Laboratory.

    ERIC Educational Resources Information Center

    Kildahl, Nicholas J.; And Others

    1986-01-01

    Dynamic crystal model kits are described. Laboratory experiments in which students use these kits to build models have been extremely successful in providing them with an understanding of the three-dimensional structures of the common cubic unit cells as well as hexagonal and cubic closest-packing of spheres. (JN)

  17. Implementing and Assessing 4-H Educational Activity Kits for Children

    ERIC Educational Resources Information Center

    Scheer, Scott D.; Yeske, Janine; Zimmer, Bruce

    2011-01-01

    Educational activity kits were developed and implemented through a statewide effort for 4-H Youth Development Extension programs serving 5-8 year-old children. The purpose of the kits was to promote life skills in children and assess the learning environment. Data was collected based on the observations of 577 children across 22 counties. Findings…

  18. Factory packed and expired - about emergency insect sting kits.

    PubMed

    Fischer, Jörg; Knaudt, Björn; Caroli, Ulrich M; Biedermann, Tilo

    2008-09-01

    Patients allergic to insect venom are instructed to always carry emergency medication-an emergency kit. According to the current guidelines, these emergency kits should contain a H1-receptor-blocking antihistamine and corticosteroid for oral use, as well as an epinephrine inhaler and in particular situations an epinephrine auto-injector. For quality management reasons patients with wasp venom allergy who presented for sting challenge provocation test were told to demonstrate their emergency kits. Concomitantly, constituents of the patient's emergency kits were checked for date of expiry of the medication and the patients were interviewed on storage and use of the emergency kits. In total 42 patients with a median duration time of systemic immunotherapy of 2.5 year were evaluated. Medication post date of expiration was found in 54% of the kits (n = 39). Only 31% of the patients could demonstrate how to use the kits correctly. Problems were especially evident concerning for using the application of the inhaler and auto-injector. 50% of the patients demonstrated using epinephrine auto-injectors in such way that an accidental injection into the fingers would have resulted. To assure safe and effective handling of all components of the emergency kit, continuous training and repeated supervised practice is necessary.

  19. Technical Services Cost Studies in ARL Libraries. SPEC Kit 125.

    ERIC Educational Resources Information Center

    Hoerman, Heidi Lee

    Based on a survey of Association of Research Libraries (ARL) member libraries in February 1986, this kit is designed to illustrate a wide range of alternative approaches to analyzing the costs of technical services. The kit consists of the following unedited primary-source documents: (1) SPEC Technical Services Costs Survey (Three-Year Update)…

  20. Using Science Kits to Construct Content Understandings in Elementary Schools

    ERIC Educational Resources Information Center

    Dickerson, Daniel; Clark, Matthew; Dawkins, Karen; Horne, Cathy

    2006-01-01

    Although there is a considerable emphasis on inquiry-based, active learning in standards documents, curriculum documents, and textbooks, there exists a great deal of debate regarding the effectiveness of specific curricular and instructional approaches, including kit-based instruction. This study examines the efficacy of science kits in improving…

  1. Energy Education Incentives: Evaluating the Impact of Consumer Energy Kits

    ERIC Educational Resources Information Center

    Kirby, Sarah D.; Guin, Autumn; Langham, Laura

    2015-01-01

    Measuring the energy and environmental impact of residential energy education efforts is difficult. The E-Conservation residential energy management program uses consumer energy kits to document the impact of energy-efficient improvements. The consumer energy kit provides an incentive for individuals attending energy education workshop, helps…

  2. Disruption of c-Kit Signaling in KitW-sh/W-sh Growing Mice Increases Bone Turnover

    PubMed Central

    Lotinun, Sutada; Krishnamra, Nateetip

    2016-01-01

    c-Kit tyrosine kinase receptor has been identified as a regulator of bone homeostasis. The c-Kit loss-of-function mutations in WBB6F1/J-KitW/W-v mice result in low bone mass. However, these mice are sterile and it is unclear whether the observed skeletal phenotype is secondary to a sex hormone deficiency. In contrast, C57BL/6J-KitW-sh/W-sh (Wsh/Wsh) mice, which carry an inversion mutation affecting the transcriptional regulatory elements of the c-Kit gene, are fertile. Here, we showed that Wsh/Wsh mice exhibited osteopenia with elevated bone resorption and bone formation at 6- and 9-week-old. The c-Kit Wsh mutation increased osteoclast differentiation, the number of committed osteoprogenitors, alkaline phosphatase activity and mineralization. c-Kit was expressed in both osteoclasts and osteoblasts, and c-Kit expression was decreased in Wsh/Wshosteoclasts, but not osteoblasts, suggesting an indirect effect of c-Kit on bone formation. Furthermore, the osteoclast-derived coupling factor Wnt10b mRNA was increased in Wsh/Wsh osteoclasts. Conditioned medium from Wsh/Wsh osteoclasts had elevated Wnt10b protein levels and induced increased alkaline phosphatase activity and mineralization in osteoblast cultures. Antagonizing Wnt10b signaling with DKK1 or Wnt10b antibody inhibited these effects. Our data suggest that c-Kit negatively regulates bone turnover, and disrupted c-Kit signaling couples increased bone resorption with bone formation through osteoclast-derived Wnt 10 b. PMID:27527615

  3. Teaching Digital Pathology: The International School of Digital Pathology and Proposed Syllabus

    PubMed Central

    Mea, Vincenzo Della; Carbone, Antonino; Di Loreto, Carla; Bueno, Gloria; De Paoli, Paolo; García-Rojo, Marcial; de Mena, David; Gloghini, Annunziata; Ilyas, Mohammad; Laurinavicius, Arvydas; Rasmusson, Allan; Milione, Massimo; Dolcetti, Riccardo; Pagani, Marco; Stoppini, Andrea; Sulfaro, Sandro; Bartolo, Michelangelo; Mazzon, Emanuela; Soyer, H. Peter; Pantanowitz, Liron

    2017-01-01

    Digital pathology is an interdisciplinary field where competency in pathology, laboratory techniques, informatics, computer science, information systems, engineering, and even biology converge. This implies that teaching students about digital pathology requires coverage, expertise, and hands-on experience in all these disciplines. With this in mind, a syllabus was developed for a digital pathology summer school aimed at professionals in the aforementioned fields, as well as trainees and doctoral students. The aim of this communication is to share the context, rationale, and syllabus for this school of digital pathology. PMID:28828198

  4. [Once again: theoretical pathology].

    PubMed

    Bleyl, U

    2010-07-01

    Theoretical pathology refers to the attempt to reintroduce methodical approaches from the humanities, philosophical logic and "gestalt philosophy" into medical research and pathology. Diseases, in particular disease entities and more complex polypathogenetic mechanisms of disease, have a "gestalt quality" due to the significance of their pathophysiologic coherence: they have a "gestalt". The Research group Theoretical Pathology at the Academy of Science in Heidelberg are credited with having revitalized the philosophical notion of "gestalt" for morphological and pathological diagnostics. Gestalt means interrelated schemes of pathophysiological significance in the mind of the diagnostician. In pathology, additive and associative diagnostic are simply not possible without considering the notion of synthetic entities in Kant's logic.

  5. Improving situation awareness with the Android Team Awareness Kit (ATAK)

    NASA Astrophysics Data System (ADS)

    Usbeck, Kyle; Gillen, Matthew; Loyall, Joseph; Gronosky, Andrew; Sterling, Joshua; Kohler, Ralph; Hanlon, Kelly; Scally, Andrew; Newkirk, Richard; Canestrare, David

    2015-05-01

    To make appropriate, timely decisions in the field, Situational Awareness (SA) needs to be conveyed in a decentralized manner to the users at the edge of the network as well as at operations centers. Sharing real-time SA efficiently between command centers and operational troops poses many challenges, including handling heterogeneous and dynamic networks, resource constraints, and varying needs for the collection, dissemination, and display of information, as well as recording that information. A mapping application that allows teams to share relevant geospatial information efficiently and to communicate effectively with one another and command centers has wide applicability to many vertical markets across the Department of Defense, as well as a wide variety of federal, state local, and non-profit agencies that need to share locations, text, photos, and video. This paper describes the Android Team Awareness Kit (ATAK), an advanced, distributed tool for commercial- off-the-shelf (COTS) mobile devices such as smartphones and tablets. ATAK provides a variety of useful SA functions for soldiers, law enforcement, homeland defense, and civilian collaborative use; including mapping and navigation, range and bearing, text chat, force tracking, geospatial markup tools, image and file sharing, video playback, site surveys, and many others. This paper describes ATAK, the SA tools that ATAK has built-in, and the ways it is being used by a variety of military, homeland security, and law enforcement users.

  6. Inventory of San Joaquin kit fox on BLM lands in southern and southwestern San Joaquin Valley. Final report

    SciTech Connect

    O'Farrell, T.P.; Kato, T.; McCue, P.; Sauls, M.L.

    1980-08-01

    The objectives of this study were to provide the Bureau of Land Management, Bakersfield District, with information on the distribution of the San Joaquin kit fox, an endangered species, on public lands in the southern and southwestern San Joaquin Valley of California, and to develop information essential for designating kit fox critical habitats on lands under their jurisdiction as outlined by the Endangered Species Act and its amendments. A total of 31,860 acres of BLM lands were surveyed using line transects at a density of 8 per linear mile. Observations were recorded on: (1) kit fox dens, tracks, scats, and remains of their prey; (2) vegetation associations; (3) topography; (4) evidence of human activities; (5) species composition and abundance of wildlife seen, especially lagomorphs; (6) presence of Eriogonum gossypinum, a plant of special interest; and (7) presence of the blunt-nosed leopard lizard, another endangered species.

  7. LogiKit - assisting complex logic specification and implementation for embedded control systems

    NASA Astrophysics Data System (ADS)

    Diglio, A.; Nicolodi, B.

    2002-07-01

    LogiKit provides an overall lifecycle solution. LogiKit is a powerful software engineering case toolkit for requirements specification, simulation and documentation. LogiKit also provides an automatic ADA software design, code and unit test generator.

  8. The Oral Pathology Related Articles Published in Iranian Journal of Pathology from 2006 to 2015

    PubMed Central

    Shamim, Thorakkal

    2016-01-01

    Background: There is a paucity of information about the oral pathology related articles published in a pathology journal. This study aimed to audit the oral pathology related articles published in Iranian Journal of Pathology (Iran J Pathol) from 2006 to 2015. Methods: Bibliometric analysis of issues of Iran J Pathol from 2006 to 2015 was performed using web-based search. The articles published were analyzed for type of article and individual topic of oral pathology. The articles published were also checked for authorship trends. Results: Out of the total 49 published articles related to oral pathology, case reports (21) and original articles (18) contributed the major share. The highest number of oral pathology related articles was published in 2011, 2014 and 2015 with 8 articles each and the least published year was 2012 with 1 article. Among the oral pathology related articles published, spindle cell neoplasms (7) followed by salivary gland tumors (5), jaw tumors (4), oral granulomatous conditions (4), lymphomas (4), oral cancer (3) and odontogenic cysts (3) form the major attraction of the contributors. The largest numbers of published articles related to oral pathology were received from Tehran University of Medical Sciences; Tehran (7) followed by Mashhad University of Medical Sciences, Mashhad (6) and Shahid Beheshti University of Medical Sciences, Tehran (5). Conclusion: This paper may be considered as a baseline study for the bibliometric information regarding oral pathology related articles published in a pathology journal. PMID:27799973

  9. The Oral Pathology Related Articles Published in Iranian Journal of Pathology from 2006 to 2015.

    PubMed

    Shamim, Thorakkal

    2016-01-01

    There is a paucity of information about the oral pathology related articles published in a pathology journal. This study aimed to audit the oral pathology related articles published in Iranian Journal of Pathology (Iran J Pathol) from 2006 to 2015. Bibliometric analysis of issues of Iran J Pathol from 2006 to 2015 was performed using web-based search. The articles published were analyzed for type of article and individual topic of oral pathology. The articles published were also checked for authorship trends. Out of the total 49 published articles related to oral pathology, case reports (21) and original articles (18) contributed the major share. The highest number of oral pathology related articles was published in 2011, 2014 and 2015 with 8 articles each and the least published year was 2012 with 1 article. Among the oral pathology related articles published, spindle cell neoplasms (7) followed by salivary gland tumors (5), jaw tumors (4), oral granulomatous conditions (4), lymphomas (4), oral cancer (3) and odontogenic cysts (3) form the major attraction of the contributors. The largest numbers of published articles related to oral pathology were received from Tehran University of Medical Sciences; Tehran (7) followed by Mashhad University of Medical Sciences, Mashhad (6) and Shahid Beheshti University of Medical Sciences, Tehran (5). This paper may be considered as a baseline study for the bibliometric information regarding oral pathology related articles published in a pathology journal.

  10. Adult c-Kit(+) progenitor cells are necessary for maintenance and regeneration of olfactory neurons.

    PubMed

    Goldstein, Bradley J; Goss, Garrett M; Hatzistergos, Konstantinos E; Rangel, Erika B; Seidler, Barbara; Saur, Dieter; Hare, Joshua M

    2015-01-01

    The olfactory epithelium houses chemosensory neurons, which transmit odor information from the nose to the brain. In adult mammals, the olfactory epithelium is a uniquely robust neuroproliferative zone, with the ability to replenish its neuronal and non-neuronal populations due to the presence of germinal basal cells. The stem and progenitor cells of these germinal layers, and their regulatory mechanisms, remain incompletely defined. Here we show that progenitor cells expressing c-Kit, a receptor tyrosine kinase marking stem cells in a variety of embryonic tissues, are required for maintenance of the adult neuroepithelium. Mouse genetic fate-mapping analyses show that embryonically, a c-Kit(+) population contributes to olfactory neurogenesis. In adults under conditions of normal turnover, there is relatively sparse c-Kit(+) progenitor cell (ckPC) activity. However, after experimentally induced neuroepithelial injury, ckPCs are activated such that they reconstitute the neuronal population. There are also occasional non-neuronal cells found to arise from ckPCs. Moreover, the selective depletion of the ckPC population, utilizing temporally controlled targeted diphtheria toxin A expression, results in failure of neurogenesis after experimental injury. Analysis of this model indicates that most ckPCs reside among the globose basal cell populations and act downstream of horizontal basal cells, which can serve as stem cells. Identification of the requirement for olfactory c-Kit-expressing progenitors in olfactory maintenance provides new insight into the mechanisms involved in adult olfactory neurogenesis. Additionally, we define an important and previously unrecognized site of adult c-Kit activity.

  11. "Back on Track": A Mobile App Observational Study Using Apple's ResearchKit Framework.

    PubMed

    Zens, Martin; Woias, Peter; Suedkamp, Norbert P; Niemeyer, Philipp

    2017-02-28

    In March 2015, Apple Inc announced ResearchKit, a novel open-source framework intended to help medical researchers to easily create apps for medical studies. With the announcement of this framework, Apple presented 5 apps built in a beta phase based on this framework. The objective of this study was to better understand decision making in patients with acute anterior cruciate ligament (ACL) ruptures. Here, we describe the development of a ResearchKit app for this study. A multilanguage observatory study was conducted. At first a suitable research topic, target groups, participating territories, and programming method were carefully identified. The ResearchKit framework was used to program the app. A secure server connection was realized via Secure Sockets Layer. A data storage and security concept separating personal information and study data was proposed. Furthermore, an efficient method to allow multilanguage support and distribute the app in many territories was presented. Ethical implications were considered and taken into account regarding privacy policies. An app study based on ResearchKit was developed without comprehensive iPhone Operating System (iOS) development experience. The Apple App Store is a major distribution channel causing significant download rates (>1.200/y) without active recruitment. Preliminary data analysis showed moderate dropout rates and a good quality of data. A total of 180 participants were currently enrolled with 107 actively participating and producing 424 completed surveys in 9 out of 24 months. ResearchKit is an easy-to-use framework and powerful tool to create medical studies. Advantages are the modular built, the extensive reach of iOS devices, and the convenient programming environment.

  12. TruSeq Stranded mRNA and Total RNA Sample Preparation Kits

    Cancer.gov

    Total RNA-Seq enabled by ribosomal RNA (rRNA) reduction is compatible with formalin-fixed paraffin embedded (FFPE) samples, which contain potentially critical biological information. The family of TruSeq Stranded Total RNA sample preparation kits provides a unique combination of unmatched data quality for both mRNA and whole-transcriptome analyses, robust interrogation of both standard and low-quality samples and workflows compatible with a wide range of study designs.

  13. Transcription Factor SCL Is Required for c-kit Expression and c-Kit Function in Hemopoietic Cells

    PubMed Central

    Krosl, Gorazd; He, Gang; Lefrancois, Martin; Charron, Frédéric; Roméo, Paul-Henri; Jolicoeur, Paul; Kirsch, Ilan R.; Nemer, Mona; Hoang, Trang

    1998-01-01

    In normal hemopoietic cells that are dependent on specific growth factors for cell survival, the expression of the basic helix-loop-helix transcription factor SCL/Tal1 correlates with that of c-Kit, the receptor for Steel factor (SF) or stem cell factor. To address the possibility that SCL may function upstream of c-kit, we sought to modulate endogenous SCL function in the CD34+ hemopoietic cell line TF-1, which requires SF, granulocyte/macrophage colony–stimulating factor, or interleukin 3 for survival. Ectopic expression of an antisense SCL cDNA (as-SCL) or a dominant negative SCL (dn-SCL) in these cells impaired SCL DNA binding activity, and prevented the suppression of apoptosis by SF only, indicating that SCL is required for c-Kit–dependent cell survival. Consistent with the lack of response to SF, the level of c-kit mRNA and c-Kit protein was significantly and specifically reduced in as-SCL– or dn-SCL– expressing cells. c-kit mRNA, c-kit promoter activity, and the response to SF were rescued by SCL overexpression in the antisense or dn-SCL transfectants. Furthermore, ectopic c-kit expression in as-SCL transfectants is sufficient to restore cell survival in response to SF. Finally, enforced SCL in the pro–B cell line Ba/F3, which is both SCL and c-kit negative is sufficient to induce c-Kit and SF responsiveness. Together, these results indicate that c-kit, a gene that is essential for the survival of primitive hemopoietic cells, is a downstream target of the transcription factor SCL. PMID:9687522

  14. Delivering a pathology curriculum in an integrated medical course.

    PubMed

    Carr, Norman J; Olmos, Martin; Bushnell, John

    2008-10-01

    Modern integrated medical curricula usually do not include a separate pathology course. Consequently, there is a risk that important pathological principles may be omitted. We aimed to ensure that pathology is properly represented by developing a core pathology curriculum created in consultation with local pathologists. Appropriate information technology to track the delivery of this material within the integrated curriculum structure was developed using a learning content management system in which a metadata schema was constructed. This allows a sophisticated view of where and how pathology appears in the course and can also increase the visibility of the subject by demonstrating the central place of pathology in medicine. In conclusion, a core curriculum in pathology that can be tracked by information technology with sufficient power and flexibility is a solution to the potential loss of pathology from integrated medical courses. We believe the result is superior to a stand-alone pathology course.

  15. Molecular pathology in anatomic pathology practice: a review of basic principles.

    PubMed

    Hunt, Jennifer L

    2008-02-01

    Molecular testing in pathology emerged shortly after polymerase chain reaction became a standard molecular biology assay. Testing efforts began in the clinical laboratories primarily with assays for genetically inherited diseases and assays for clonality in hematologic malignancies. Today, the field has evolved into "molecular diagnostics," which encompasses testing in almost every area of anatomic pathology. Molecular testing is now even making its way definitively into both surgical pathology and cytopathology, although molecular anatomic pathology is still young with few standard tissue-based molecular assays. As more clinically valuable information is gained from molecular pathology testing of tissues, unique challenges are also becoming apparent at the intersection between tissue diagnosis and DNA diagnosis. This review focuses on basic molecular pathology concepts, with particular emphasis on the challenge of tissue-based testing in anatomic pathology.

  16. Evaluation of commercially available RNA amplification kits for RNA sequencing using very low input amounts of total RNA.

    PubMed

    Shanker, Savita; Paulson, Ariel; Edenberg, Howard J; Peak, Allison; Perera, Anoja; Alekseyev, Yuriy O; Beckloff, Nicholas; Bivens, Nathan J; Donnelly, Robert; Gillaspy, Allison F; Grove, Deborah; Gu, Weikuan; Jafari, Nadereh; Kerley-Hamilton, Joanna S; Lyons, Robert H; Tepper, Clifford; Nicolet, Charles M

    2015-04-01

    This article includes supplemental data. Please visit http://www.fasebj.org to obtain this information.Multiple recent publications on RNA sequencing (RNA-seq) have demonstrated the power of next-generation sequencing technologies in whole-transcriptome analysis. Vendor-specific protocols used for RNA library construction often require at least 100 ng total RNA. However, under certain conditions, much less RNA is available for library construction. In these cases, effective transcriptome profiling requires amplification of subnanogram amounts of RNA. Several commercial RNA amplification kits are available for amplification prior to library construction for next-generation sequencing, but these kits have not been comprehensively field evaluated for accuracy and performance of RNA-seq for picogram amounts of RNA. To address this, 4 types of amplification kits were tested with 3 different concentrations, from 5 ng to 50 pg, of a commercially available RNA. Kits were tested at multiple sites to assess reproducibility and ease of use. The human total reference RNA used was spiked with a control pool of RNA molecules in order to further evaluate quantitative recovery of input material. Additional control data sets were generated from libraries constructed following polyA selection or ribosomal depletion using established kits and protocols. cDNA was collected from the different sites, and libraries were synthesized at a single site using established protocols. Sequencing runs were carried out on the Illumina platform. Numerous metrics were compared among the kits and dilutions used. Overall, no single kit appeared to meet all the challenges of small input material. However, it is encouraging that excellent data can be recovered with even the 50 pg input total RNA.

  17. Loss of c-KIT expression in thyroid cancer cells

    PubMed Central

    Panebianco, Federica; Tantillo, Elena; La Ferla, Marco; Menicagli, Michele; Aretini, Paolo; Apollo, Alessandro; Naccarato, Antonio Giuseppe; Marchetti, Ivo; Mazzanti, Chiara Maria

    2017-01-01

    Papillary thyroid carcinoma is the most frequent histologic type of thyroid tumor. Few studies investigated the role of c-KIT expression in thyroid tumors, suggesting a role for this receptor and its ligand in differentiation and growth control of thyroid epithelium and a receptor loss following malignant transformation. We investigated and correlated c-KIT expression levels and two known markers of thyrocytes differentiation, PAX8 and TTF-1, in malignant and benign cytological thyroid samples. Moreover, we performed functional studies on human papillary thyroid carcinoma cell line to associated c-KIT expression to thyrocytes differentiation and tumor proliferation. c-KIT and PAX8 expression resulted higher in benign samples compared to the malignant ones, and the expression levels of these two genes were significantly correlated to each other. We also observed that c-KIT overexpression led to an increase of PAX8 expression level together with a decrease of proliferation. Furthermore, c-KIT overexpressing cells showed a regression of typical morphological features of malignancy. Taken together these results suggest that c-KIT could be involved in the differentiation of thyroid cells and in tumor progression. PMID:28301608

  18. Loss of c-KIT expression in thyroid cancer cells.

    PubMed

    Franceschi, Sara; Lessi, Francesca; Panebianco, Federica; Tantillo, Elena; La Ferla, Marco; Menicagli, Michele; Aretini, Paolo; Apollo, Alessandro; Naccarato, Antonio Giuseppe; Marchetti, Ivo; Mazzanti, Chiara Maria

    2017-01-01

    Papillary thyroid carcinoma is the most frequent histologic type of thyroid tumor. Few studies investigated the role of c-KIT expression in thyroid tumors, suggesting a role for this receptor and its ligand in differentiation and growth control of thyroid epithelium and a receptor loss following malignant transformation. We investigated and correlated c-KIT expression levels and two known markers of thyrocytes differentiation, PAX8 and TTF-1, in malignant and benign cytological thyroid samples. Moreover, we performed functional studies on human papillary thyroid carcinoma cell line to associated c-KIT expression to thyrocytes differentiation and tumor proliferation. c-KIT and PAX8 expression resulted higher in benign samples compared to the malignant ones, and the expression levels of these two genes were significantly correlated to each other. We also observed that c-KIT overexpression led to an increase of PAX8 expression level together with a decrease of proliferation. Furthermore, c-KIT overexpressing cells showed a regression of typical morphological features of malignancy. Taken together these results suggest that c-KIT could be involved in the differentiation of thyroid cells and in tumor progression.

  19. Detection of hazelnuts and almonds using commercial ELISA test kits.

    PubMed

    Garber, Eric A E; Perry, Jesse

    2010-03-01

    Three commercial sandwich enzyme-linked immunosorbent assay (ELISA) test kits for the detection of hazelnuts and almonds were evaluated. Limits of detection and dynamic ranges were determined for hazelnuts and almonds spiked into cooked oatmeal, dipping chocolate, and muffins (baked). The limit of detection values varied from 1 to 38 μg/g, depending on the food matrix and ELISA test kit. Percent recoveries based on the standards supplied with the test kits varied from 10% to 170%. It is impossible to ascertain whether the percent recoveries reflect the performance of the ELISAs or differences between the protein content of the nuts used to spike the samples and the test kit standards. Unfortunately, reference materials do not exist that can be used to compare the results from different test kits and standardize the test kit standards. Also, insufficient knowledge regarding the epitope specificity of the antibodies used in the ELISAs further hinders interpretation of the results generated by the different test kits.

  20. Handheld computing in pathology

    PubMed Central

    Park, Seung; Parwani, Anil; Satyanarayanan, Mahadev; Pantanowitz, Liron

    2012-01-01

    Handheld computing has had many applications in medicine, but relatively few in pathology. Most reported uses of handhelds in pathology have been limited to experimental endeavors in telemedicine or education. With recent advances in handheld hardware and software, along with concurrent advances in whole-slide imaging (WSI), new opportunities and challenges have presented themselves. This review addresses the current state of handheld hardware and software, provides a history of handheld devices in medicine focusing on pathology, and presents future use cases for such handhelds in pathology. PMID:22616027