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Sample records for patients preliminary results

  1. Music therapy for coma patients: preliminary results.

    PubMed

    Sun, J; Chen, W

    2015-04-01

    The application of quantitative EEG (δ+θ/α+β value) and GCS value to evaluate the role of music therapy for traumatic brain injury coma patients. Forty patients of traumatic brain injury coma were selected to meet the inclusion criteria. Twenty cases were selected for the rehabilitation, neurology and neurosurgery ward, whose families could actively cooperate with, and the patients could receive a long-term fixed nursing staff with formal music therapy (music group). Twenty cases were in the intensive care unit of the rehabilitation, neurology and neurosurgery ward. Their families members cooperated poorly, had often changing nursing staff, and without a formal music therapy (control group). After a one monthe follow up, the GCS value and quantitative EEG (δ+θ/α+β value) were compared between the two groups. Between the two groups, except for the presence or absence of formal music therapy, the rest of treatment had no significant difference and was matched by age, gender, and injury types. In 40 cases of traumatic brain injury patients, the GCS value increased in the music group after treatment when compared to the control group. The difference between the two groups was significant (p < 0.05). The quantitative EEG value (δ+θ/α+β value) of music group values were decreased after treatment, and the difference was significant compared with the control group (p < 0.05). Through the quantitative EEG (δ+θ/α+β value) and the GCS observation score, music therapy in patients with craniocerebral trauma coma has obviously an effect on promoting to regain consciousness. The quantitative EEG (δ+θ/α+β value) can be used as an objective index to evaluate the state of brain function.

  2. Sound localization in patients with cochlear implant--preliminary results.

    PubMed

    Luntz, Michal; Brodsky, Alexander; Hafner, Hava; Shpak, Thalma; Feiglin, Hava; Pratt, Hillel

    2002-05-31

    To evaluate sound localization ability in patients with unilateral cochlear implant, who do not wear a hearing aid on the contralateral ear, and to try to improve this ability by training. Tertiary academic referral center. In the initial test, patients were exposed to sound stimuli from different directions and were asked to localize them. Following a training period the patients were re-evaluated by the same test. For each test, the percentage of correct answers and the final test score were calculated. In the initial test, the mean score of the study group of four cochlear implant users was 42.8 (out of a maximal score of 100), the mean rate of correct responses was 27.5%. Following a training period (6.5 sessions on the average), on the final test the mean score of the group was 74.3, while the mean rate of correct responses was 66.5%. The results demonstrated that patients with unilateral cochlear implant have some ability to localize sound, and that this ability may be improved by regular training.

  3. [Intensified smoking cessation for diabetic patients--preliminary results].

    PubMed

    Brath, H; Lasar, D; Buchhäusl, I; Kästenbauer, T; Binter, E

    1999-01-01

    Cigarette smoking is the most prominent yet avoidable cause of illness in the general population as well as in patients with diabetes. The danger of developing late complications is much higher for smoking than for non-smoking diabetic patients. The aim of this study was to determine whether an intensified smoking cessation program for patients with diabetes, including an initial 3 week-period of inpatient cessation, is effective and more successful than a mere outpatient program. The outpatient program consisted of at least 7 consultations within 2 years, and included nicotine replacement therapy, steps for modifying the smokers' behavioural patterns, advice in dietary and exercise as well as measurements of amounts of exhaled carbonmonoxide and lung function. In the inpatient program the patients passed the first 3 cessation weeks in a specialised clinic providing a similar, but intensified program, aside from daily life and professional routine. The following consultations corresponded to those of the outpatient program. Altogether we analysed 89 patients (64 in the outpatient and 25 in the inpatient program).

  4. Preliminary results and worst-case analysis of in patient scoliosis rehabilitation.

    PubMed

    Weiss, H R; Lohschmidt, K; el-Obeidi, N; Verres, C

    1997-01-01

    The purpose of this study was to assess the effectiveness of a scoliosis-specific rehabilitation programme as it is carried out in the Katharina Schroth Spinal Deformities Rehabilitation Center. Physiotherapy in the treatment of scoliosis patients is still regarded as ineffective since the study by the American Orthopedic Association in 1941, which showed that general exercises could not influence the natural history of scoliosis. However, specific exercise programmes were not known in the USA at that time. This preliminary study started in 1989 with the following inclusion criteria: (1) diagnosis of idiopathic scoliosis; (2) risser sign < 4; (3) no treatment other than physiotherapy; (4) first control after 1-3 years during repeated in patient treatment; (5) standing AP radiograph taken not more than 6 months before the first in patient treatment. A total of 181 scoliosis patients, with an average age of 12.7 years and an average angle of curvature of 27% according to Cobb, were included in this study. The average risser sign was 1.4, the average follow-up 33 months. The Cobb angle of the major curve was measured in a standardized way. The results of our preliminary study were compared to natural history as known from literature. For the worst-case analysis additionally a questionnaire was sent to the non-repeaters treated at our centre at the same time (1989 and 1990) as the patient sample described above, taking into account the same inclusion criteria for this patient sample except point 4. Results showed that progression as usually defined (increase in curvature of 5 degrees or more per year) has not been found in the preliminary study. The patient sample of this study was divided into different age groups and different groups of curve magnitude, for comparison with other studies. Additional to the patient sample of the preliminary study, 116 of the patients from the years 1989 and 1990 fulfilled the inclusion criteria of the preliminary study with the

  5. Acceptability of robotic technology in neuro-rehabilitation: preliminary results on chronic stroke patients.

    PubMed

    Mazzoleni, Stefano; Turchetti, Giuseppe; Palla, Ilaria; Posteraro, Federico; Dario, Paolo

    2014-09-01

    During the last decade, different robotic devices have been developed for motor rehabilitation of stroke survivors. These devices have been shown to improve motor impairment and contribute to the understanding of mechanisms underlying motor recovery after a stroke. The assessment of the robotic technology for rehabilitation assumes great importance. The aim of this study is to present preliminary results on the assessment of the acceptability of the robotic technology for rehabilitation on a group of thirty-four chronic stroke patients. The results from questionnaires on the patients' acceptability of two different robot-assisted rehabilitation scenarios show that the robotic approach was well accepted and tolerated by the patients.

  6. Collaborative Care for Patients With Severe Personality Disorders: Preliminary Results and Active Ingredients From a Pilot Study (Part I).

    PubMed

    Stringer, Barbara; van Meijel, Berno; Karman, Pieter; Koekkoek, Bauke; Hoogendoorn, Adriaan W; Kerkhof, Ad J F M; Beekman, Aartjan T F

    2015-07-01

    To test if a collaborative care program (CCP) with nurses in a coordinating position is beneficial for patients with severe personality disorders. A pilot study with a comparative multiple case study design using mixed methods investigating active ingredients and preliminary results. Most patients, their informal caregivers, and nurses value (parts of) the CCP positively; preliminary results show a significant decrease in severity of borderline symptoms. With the CCP, we may expand the supply of available treatments for patients with (severe) personality disorders, but a larger randomized controlled trial is warranted to confirm our preliminary results. © 2014 Wiley Periodicals, Inc.

  7. Applicability of bosentan in Dutch patients with Eisenmenger syndrome: preliminary results on safety and exercise capacity

    PubMed Central

    Duffels, M.G.J.; Berger, R.M.F.; Bresser, P.; de Bruin-Bon, H.A.C.M.; Hoendermis, E.; Bouma, B.J.; Mulder, B.J.M.

    2006-01-01

    Background The purpose of this study was to investigate the applicability of bosentan treatment in a broad selection of patients with Eisenmenger syndrome. Methods Dutch patients with Eisenmenger syndrome in New York Heart Association functional class III, 9 (41%) male and 13 (59%) female, including 11 patients with Down syndrome (50%), aged 20 to 61 years (median 37 years), were screened for an open-label, standardised treatment protocol. Patients underwent clinical examinations, six-minute walk test (6-MWT), resting oxygen saturation measurements, cardiac MRI, Doppler echocardiography, lung function tests and exercise capacity testing by peak oxygen consumption at baseline. At 12 weeks of treatment 6-MWT and at 26 weeks 6-MWT and Doppler echocardiography were repeated. Results Median follow-up of the patients who started bosentan treatment was five months (range 0.5 to 9.6 months). Oxygen saturation at baseline was 83% (range 76 to 91%) and did not decrease during treatment. Compared with baseline, 6-MWT increased after 12 weeks from 333±93 m to 384±89 m. None of the patients discontinued medication and no liver function abnormalities were observed. Of all Doppler echocardiographic and MRI parameters measured for right ventricular function, tricuspid annular peak systolic velocities using tissue Doppler imaging (TDI-S) was the only independent predictor for six-minute walk test (β=0.8, p=0.001). Conclusion Bosentan may be safely applied in patients with Eisenmenger syndrome combined with complex congenital heart disease or with Down syndrome. Our preliminary results suggest that exercise tolerance improves during the first months of bosentan treatment. ImagesFigure 1Figure 2AFigure 2B PMID:25696620

  8. Prostatic Artery Embolization as a Primary Treatment for Benign Prostatic Hyperplasia: Preliminary Results in Two Patients

    SciTech Connect

    Carnevale, Francisco Cesar; Antunes, Alberto Azoubel; Motta Leal Filho, Joaquim Mauricio da; Oliveira Cerri, Luciana Mendes de; Baroni, Ronaldo Hueb; Marcelino, Antonio Sergio Zafred; Freire, Geraldo Campos; Moreira, Airton Mota; Srougi, Miguel; Cerri, Giovanni Guido

    2010-04-15

    Symptomatic benign prostatic hyperplasia (BPH) typically occurs in the sixth and seventh decades, and the most frequent obstructive urinary symptoms are hesitancy, decreased urinary stream, sensation of incomplete emptying, nocturia, frequency, and urgency. Various medications, specifically 5-{alpha}-reductase inhibitors and selective {alpha}-blockers, can decrease the severity of the symptoms secondary to BPH, but prostatectomy is still considered to be the traditional method of management. We report the preliminary results for two patients with acute urinary retention due to BPH, successfully treated by prostate artery embolization (PAE). The patients were investigated using the International Prostate Symptom Score, by digital rectal examination, urodynamic testing, prostate biopsy, transrectal ultrasound (US), and magnetic resonance imaging (MRI). Uroflowmetry and postvoid residual urine volume complemented the investigation at 30, 90, and 180 days after PAE. The procedure was performed under local anesthesia; embolization of the prostate arteries was performed with a microcatheter and 300- to 500-{mu}m microspheres using complete stasis as the end point. One patient was subjected to bilateral PAE and the other to unilateral PAE; they urinated spontaneously after removal of the urethral catheter, 15 and 10 days after the procedure, respectively. At 6-month follow-up, US and MRI revealed a prostate reduction of 39.7% and 47.8%, respectively, for the bilateral PAE and 25.5 and 27.8%, respectively, for the patient submitted to unilateral PAE. The early results, at 6-month follow-up, for the two patients with BPH show a promising potential alternative for treatment with PAE.

  9. Preliminary results of DISTO

    NASA Astrophysics Data System (ADS)

    Bedfer, Y.

    1998-05-01

    DISTO is a spectrometer experiment installed at Saturne in Saclay to study strangeness production in p¯p reactions. It has entered its production phase in the second semester of 1996 and is to complete it by the time Saturne closes at the end of 1997. Preliminary results bearing on the two main items of its physics program. viz. polarization in associated hyperon production and OZ1 rule assessment in vector meson production, and obtained at 2.85 GeV are presented.

  10. Simple Reshaping of the Breast in Massive Weight Loss Patients: Promising Preliminary Results.

    PubMed

    Ikander, Peder; Gad, Dorte; Gunnarsson, Gudjon Leifur; Boljanovic, Slaven; Salzberg, Andrew; Sørensen, Jens Ahm; Thomsen, Jørn Bo

    2017-02-01

    The challenging breast reshaping after massive weight loss (MWL) has been increasingly performed as the number of bariatric surgery procedures increase worldwide. The breasts often appear wide, lateralized, and deflated, with significant ptosis. The aim of this article is to share our initial experience using the lower pole subglandular advancement mastoplasty (LOPOSAM) technique to reshape the breasts in MWL patients and to elaborate the technical details and simplicity of the method in the attached video. We performed 30 LOPOSAM procedures in 15 MWL women aged 24 to 63 years from February to September 2015. We used a wise pattern mark-up and a superior based pedicle for the relocation of the nipple areola complex. The key step for the autoaugmentation was an inferior and central mound based parabola-shaped flap, which was placed in a subglandular pocket to reshape the breast and lift the inframammary crease. The median operation time for the LOPOSAM procedure was 81 minutes (range, 35-160 minutes) by 2 surgeons. The median weight loss was 64 kg (range, 45-103) and 22 body mass index units (range, 16-33) per patient. The median follow-up was 240 days (range, 105 Powered by Editorial Manager and ProduXion Manager from Aries Systems Corporation to 345). The surgical goal was achieved in all cases. Four complications occurred in 3 patients, 1 major, a hematoma-requiring surgery and 3 minor wound dehiscence. The self-reported patient satisfaction was high, 13 were very satisfied with the result, 1 satisfied, and 1 less satisfied. The LOPOSAM technique is quick and simple to perform, and the preliminary results are promising. However, a longer follow-up is needed to confirm this.

  11. Effects of hormones on cognition in schizophrenic male patients--preliminary results.

    PubMed

    Bratek, Agnieszka; Koźmin-Burzyńska, Agnieszka; Krysta, Krzysztof; Cierpka-Wiszniewska, Katarzyna; Krupka-Matuszczyk, Irena

    2015-09-01

    Schizophrenia is a prevalent neurodevelopmental disorder of an unknown etiology and a variable phenotypic expression. In the recent years, the impact of hormones on the course of schizophrenia has been investigated. This study is aimed at assessing the level of correlating serum levels of hormones in schizophrenic male patients with their cognitive functioning measured with neuropsychological tests. In the index group there were 15 medicated male schizophrenic patients. In the control group there were 15 age and education matched healthy men. All subjects underwent analysis of serum hormones level (TSH, testosterone, estradiol, FSH, LH, progesterone and prolactin) and a battery of tests (Trail Making Test A and B, Stroop Test, Verbal and Semantic Fluency Test). The mean serum levels of the following hormones were higher in the index group than in the control group: TSH (1.76 mIU/L vs 1.58 mIU/L; p=0.66), progesterone (0.85 ng/ml vs 0.69 ng/ml; p=0.22) and prolactin (558.71 uIU/ml vs 181 uIU/ml; p=0.025). The mean levels of estradiol (24.36 pg/ml vs 25.40 ng/ml; p=0.64), FSH (3.17 mIU/ml vs 5.72 mIU/ml; p=0.019), LH (3.85 mIU/ml vs 5.77 mIU/ml; p=0.056) and testosterone (2.90 ng/ml vs 5.38 ng/ml; p=0.003) were higher in the control group. In the index group there were significant negative correlations between FSH and semantic fluency (ρ=-0.678606), progesterone and: TMT B (ρ=-0.586763), Stroop 1 (ρ=-0.701880) and Stroop 2 (ρ=-0.601074) and prolactin and TMT A (ρ=-0.579607). The preliminary results of our study show that serum levels of FSH and testosterone are significantly lower, whereas the level of prolactin is markedly higher, in schizophrenic male patients than in healthy men. There is an inverse correlation between serum levels of progesterone, FSH and prolactin and the results of certain cognitive functioning tests in schizophrenic men.

  12. A New Method of Airway Management in Patients Undergoing Gasserian Ganglion Thermal Coagulation: Preliminary Results.

    PubMed

    Klug, Wolfgang; Reiterer, Christian; Bukaty, Adam; Schramm, Wolfgang

    2015-07-01

    Airway management in patients undergoing neurosurgical interventions for trigeminal neuralgia can often prove difficult. This is because the patient's assistance is required during this neurosurgical intervention, and moreover, the site of puncture lies within the working area of the anesthesiologists. An obvious alternative for airway management is the use of a nasopharyngeally placed tube. The purpose of the present study was to objectify the gas exchange in patients during this new ventilation technique. In 5 patients, a tube with a 5 mm internal diameter was placed nasopharyngeally after induction of general anesthesia and ventilation was then manually assisted. The intraoperative partial pressure values of CO(2) (pvCO(2)) and O(2) (pvO(2)) in the venous blood were then compared with their respective patient's preoperative baseline pvCO(2) and pvO(2) levels. Blood pressure, heart rate, and SpO(2) were continuously and noninvasively monitored. During the entire surgical intervention, patients were ventilated with a fraction of inspired oxygen (FiO(2)) of 1.0 and a fresh gas flow of 18 L per minute. All patients exhibited sufficient oxygenation during the entire procedure under manual ventilation. There were no excessive deviations in pvCO(2) from baseline levels. Furthermore, no incidents of hemodynamic instability occurred. Mean duration of the neurosurgical procedure was 54 minutes. Impairment of intraoperative verbal communication was not observed with the nasopharyngeal tube in situ. This preliminary study suggests that manually assisted ventilation with pure oxygen using a nasopharyngeally placed tube seems to be a sufficient airway management technique during thermal coagulation of the Gasserian ganglion.

  13. Alprazolam augmentation of the antipsychotic effects of fluphenazine in schizophrenic patients. Preliminary results.

    PubMed

    Wolkowitz, O M; Breier, A; Doran, A; Kelsoe, J; Lucas, P; Paul, S M; Pickar, D

    1988-07-01

    Alprazolam was added, under double-blind conditions, to stable fluphenazine hydrochloride regimens in 12 symptomatic, chronically ill inpatients with schizophrenia. The addition of alprazolam was associated with significant, albeit modest, reductions in global psychosis, thought disorder, and paranoia ratings, with a return to pretreatment levels on discontinuation of alprazolam treatment. Improvement in "negative symptoms" such as emotional withdrawal paralleled the changes in "positive symptoms" but did not, in itself, reach statistical significance. There were no significant changes in group mean plasma levels of homovanillic acid or 3-methoxy-4-hydroxyphenylglycol during alprazolam treatment, although group mean serum cortisol levels were significantly decreased by alprazolam treatment. Patients who responded favorably to alprazolam treatment were significantly more psychotic or anxious before treatment, were older, showed significant alprazolam-associated reductions in plasma levels of homovanillic acid, and had significantly more prominent prefrontal cortex atrophy on computed tomographic scans than patients in whom alprazolam was without therapeutic effect. These preliminary data, based on a small sample, suggest that some patients with schizophrenia who are only partially responsive to standard neuroleptic treatment may benefit from the addition of triazolobenzodiazepines, such as alprazolam.

  14. Efficacy of metacognitive training for patients with borderline personality disorder: Preliminary results.

    PubMed

    Schilling, Lisa; Moritz, Steffen; Kriston, Levente; Krieger, Maria; Nagel, Matthias

    2017-09-11

    'Metacognitive training for borderline personality disorder' (B-MCT) represents a complementary group intervention. It aims at raising awareness for cognitive biases that may play an important role in the development and maintenance of borderline symptomatology. For the present study, we evaluated the effectiveness of this new approach against a control condition. Seventy-four inpatients with borderline personality disorder (BPD) were randomly assigned to metacognitive training for BPD or progressive muscle relaxation training as an add-on intervention to treatment as usual. Severity of symptomatology was assessed at baseline, four weeks after beginning and six months after completion of the intervention. The per-protocol and intention-to-treat analyses revealed that patients in the metacognitive training group showed significantly greater reductions on the primary outcome (Borderline Symptom List-23) after six months. Progressive muscle relaxation was superior in alleviating depressive symptoms (secondary outcome: Beck Depression Inventory) at the long-term follow-up. Findings provide preliminary evidence that metacognitive training for BPD yields surplus effects to standard treatment. Copyright © 2017. Published by Elsevier B.V.

  15. Long-term monitoring of sleep apnea at home in heart failure patients: preliminary results from the HHH study.

    PubMed

    Pinna, G D; Maestri, R; Gobbi, E; Capomolla, S; Campana, C; Emdin, M; Di Lenarda, A; La Rovere, M T; Andrews, D; Johnson, P; Mortara, A; Sleight, P

    2004-01-01

    Sleep apnea is very common in patients with chronic heart failure (CHF) and has important implications in terms of morbidity, mortality and clinical management. Home respiratory telemonitoring might constitute a potential low-cost, widely-applicable alternative to traditional polysomnography in the evaluation and long-term monitoring of breathing disorders in these patients. In this paper we briefly describe the technological infrastructure and present preliminary results of the European Community multicountry trial HHH (Home or Hospital in Heart Failure), which is currently testing a novel system for home telemonitoring of cardiorespiratory signals in CHF patients. The recording and transmitting devices are suitable to be self-managed by the patient. We give a detailed report on the prevalence of nocturnal respiratory disorders at the beginning of the one-year follow-up and on their persistency over the following recordings (one per month). These preliminary findings clearly indicate that intermittent home telemonitoring of respiratory signals based on patient's self-management is feasible in CHF patients and the compliance is high. Reported statistics unambiguously confirm the high prevalence of nocturnal breathing disorders in these patients and clearly show that this phenomenon tends to persist over time.

  16. Clinical Application of Autologous Adipose Stem Cells in Patients with Multiple Sclerosis: Preliminary Results.

    PubMed

    Stepien, Adam; Dabrowska, Natalia L; Maciagowska, Marzena; Macoch, Renata Piusinska; Zolocinska, Aleksandra; Mazur, Slawomir; Siennicka, Katarzyna; Frankowska, Emilia; Kidzinski, Rafał; Chalimoniuk, Małgorzata; Pojda, Zygmunt

    2016-01-01

    The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of follow-up, some patients showed "enticing" improvements on some exploratory efficacy measures, although a significant benefit was not observed for any measure across the entire group. Neither the progression of disability nor relapses were observed in any cases. In four patients, we found new gadolinium+ (Gd+) lesions on MRI. Our results indicate that ASC therapy is safe and does not produce any substantial side effects. Disease progression-free survival (PFS) of 18 months was seen in all patients with RRMS and SPMS. In these patients, EDSS scores did not progress above baseline scores. Gd-enhancing lesions were observed in two cases with RRMS, but these patients did not exhibit changes in EDSS score. Conclusion. Intrathecal treatment with ASCs is an attractive form of therapy for patients with MS but should be reserved for cases with aggressive disease progression, for cases that are still in the inflammatory phase, and for the malignant form.

  17. Is there a problem with quality in the Greek hospital sector? Preliminary results from a patient satisfaction survey.

    PubMed

    Niakas, D; Gnardellis, C; Theodorou, M

    2004-02-01

    Many Greek politicians and media attribute high dissatisfaction with the public health services to the quality of public hospitals. Provoking this view, this study attempts to investigate the patient's opinion and provides some preliminary results for the level of services provided by three public hospitals. A patient satisfaction survey with a self-administered questionnaire of 1295 adult patients show high rates for medical and nursing services and fair rates for hotel services and facilities. The medical-nursing index (which can range from 0 to 100) shows a mean of 86.4 and the rate for the hotel services is 75.9. Statistical analysis shows different satisfaction rates by age and level of education, an outcome that is consistent with other similar satisfaction studies. Differences of patient satisfaction relating to the area of hospital need to be examined carefully by gathering more data from Greek hospitals. Our preliminary results demonstrate that the high dissatisfaction of the public cannot be attributed to the quality of hospital care.

  18. Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study

    PubMed Central

    Ansell, Stephen M.; Armand, Philippe; Scott, Emma C.; Halwani, Ahmad; Gutierrez, Martin; Millenson, Michael M.; Cohen, Adam D.; Schuster, Stephen J.; Lebovic, Daniel; Dhodapkar, Madhav; Avigan, David; Chapuy, Bjoern; Ligon, Azra H.; Freeman, Gordon J.; Rodig, Scott J.; Cattry, Deepika; Zhu, Lili; Grosso, Joseph F.; Bradley Garelik, M. Brigid; Shipp, Margaret A.; Borrello, Ivan; Timmerman, John

    2016-01-01

    Purpose Cancer cells can exploit the programmed death-1 (PD-1) immune checkpoint pathway to avoid immune surveillance by modulating T-lymphocyte activity. In part, this may occur through overexpression of PD-1 and PD-1 pathway ligands (PD-L1 and PD-L2) in the tumor microenvironment. PD-1 blockade has produced significant antitumor activity in solid tumors, and similar evidence has emerged in hematologic malignancies. Methods In this phase I, open-label, dose-escalation, cohort-expansion study, patients with relapsed or refractory B-cell lymphoma, T-cell lymphoma, and multiple myeloma received the anti–PD-1 monoclonal antibody nivolumab at doses of 1 or 3 mg/kg every 2 weeks. This study aimed to evaluate the safety and efficacy of nivolumab and to assess PD-L1/PD-L2 locus integrity and protein expression. Results Eighty-one patients were treated (follicular lymphoma, n = 10; diffuse large B-cell lymphoma, n = 11; other B-cell lymphomas, n = 10; mycosis fungoides, n = 13; peripheral T-cell lymphoma, n = 5; other T-cell lymphomas, n = 5; multiple myeloma, n = 27). Patients had received a median of three (range, one to 12) prior systemic treatments. Drug-related adverse events occurred in 51 (63%) patients, and most were grade 1 or 2. Objective response rates were 40%, 36%, 15%, and 40% among patients with follicular lymphoma, diffuse large B-cell lymphoma, mycosis fungoides, and peripheral T-cell lymphoma, respectively. Median time of follow-up observation was 66.6 weeks (range, 1.6 to 132.0+ weeks). Durations of response in individual patients ranged from 6.0 to 81.6+ weeks. Conclusion Nivolumab was well tolerated and exhibited antitumor activity in extensively pretreated patients with relapsed or refractory B- and T-cell lymphomas. Additional studies of nivolumab in these diseases are ongoing. PMID:27269947

  19. Use of Molecular Profiling to Guide Treatment Decisions in Patients with Neuroendocrine Tumors: Preliminary Results.

    PubMed

    Cutler, Holt S; Ogando, Paul; Uhr, Joshua H; Gonzalez, Dani O; Warner, Richard R P; Divino, Celia M

    2016-04-01

    This case series demonstrates the potential of molecular profiling to improve selection of antitumor therapies in the treatment of patients with neuroendocrine and carcinoid tumors. Carcinoid tumors resected at one institution over a 3-year period were sent for molecular profiling to guide choice of treatment. Potentially beneficial therapies were identified based on the measured expression of 20 proteins and oncogenes and a comprehensive review of the chemotherapy response literature. The clinical charts of 41 patients were reviewed retrospectively, and 12 were selected as representatives of the range of effects molecular profiling has on carcinoid treatment. Their presentation, molecular profile results, treatment, and disease progression is reviewed in the following case series. A total of nine patients were treated with drugs identified as potentially beneficial by molecular profile reports. These include capecitabine, 5-fluorouracil, temozolomide, oxaliplatin, and gemcitabine. Based on clinical symptoms, serum markers of disease, and radiographic evidence five of nine patients responded to treatment, two had mixed responses, and two did not respond to treatment. At this early juncture, our critique of molecular profiling for neuroendocrine tumors is favorable, as a significant number of our patients responded to drugs identified by molecular profiling as potentially beneficial.

  20. Diagnostic performance of 320-detector CT coronary angiography in patients with atrial fibrillation: preliminary results.

    PubMed

    Xu, Lei; Yang, Lin; Fan, Zhanming; Yu, Wei; Lv, Biao; Zhang, Zhaoqi

    2011-05-01

    To evaluate the feasibility, diagnostic accuracy, and radiation dose of CT coronary angiography (CTCA) in patients with atrial fibrillation (AF) using 320-detector CT. Thirty-seven patients with persistent AF and suspected coronary artery disease (CAD) were enrolled. All patients underwent both 320-detector CTCA and conventional coronary angiography (CCA). CT image quality and the presence of significant (≥ 50%) stenosis were evaluated by two radiologists blinded to the results of CCA. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated using CCA as the reference standard. Differences in detection of coronary artery stenosis between 320-detector CTCA and CCA were evaluated with McNemar's test. Patient radiation dose was calculated by multiplying dose length product by conversion coefficient of 0.017. In total 474 evaluated coronary segments, 459 (96.8%) segments were diagnostically evaluable. On per-segment analysis, sensitivity, specificity, PPV and NPV were 90.0% (18 of 20), 99.3% (436 of 439), 85.7% (18 of 21) and 99.5% (436 of 438). No significant difference was found between 320-detector CTCA and CCA on the detection of significant stenosis (P = 1.000). Effective doses of 320-detector CTCA was 13.0 ± 4.7 mSv. 320-detector CTCA is feasible and accurate in excluding CAD in patients with AF.

  1. Increased intracranial pressure in myelomeningocele (MMC) patients never shunted: results of a prospective preliminary study.

    PubMed

    Iborra, J; Pagès, E; Cuxart, A; Poca, A; Sahuquillo, J

    2000-08-01

    In some young adults non-shunted myelomeningocele (MMC) patients without symptoms or with unspecific clinical findings, moderate or severe stabilised ventriculomegaly are observed in control CT scans. Physicians are then faced with the so-called 'Arrested Hydrocephalus' (AH) syndrome. The present study is part of a prospective protocol in which patients with hydrocephalus associated with MMC and long-term clinical diagnosis of AH were included. To evaluate myelomeningocele patients never shunted with clinical and/or CT scan criteria compatible with AH. Multidisciplinary Spina Bifida Unit in a tertiary university hospital in Barcelona, Spain. Fourteen MMC patients were selected, in all of them, continuous intracranial pressure (ICP) monitoring was performed. Analysis of the ICP records was done using the method described by Borgesen in mmHg. All patients were also studied by intelligence quotient (IQ) testing before and after shunting. The CT in all the study cases showed an Evans ratio patients (11/14) presented continuous high or intermittently raised ICP (active or unstable compensated hydrocephalus group) and in three (3/14) cases we confirmed the diagnosis of arrested hydrocephalus. There were no complications associated with ICP monitoring. In view of our results, we believe that in all non-shunted cases with clinical and/or CT scan criteria compatible with AH, the use of an objective method, such as continuous ICP monitoring, is necessary to diagnose arrested hydrocephalus, and a more comprehensive method that includes extensive neuropsychological valoration should be developed for the diagnosis and treatment of arrested hydrocephalus. Supported in part by Grant number 97-0923 from the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISS).

  2. Preliminary Results on Setup Precision of Prone-Lateral Patient Positioning for Whole Breast Irradiation

    SciTech Connect

    Veldeman, Liv; Speleers, Bruno; Bakker, Marlies; Jacobs, Filip; Coghe, Marc; De Gersem, Werner; Impens, Aline; Nechelput, Sarah; De Wagter, Carlos

    2010-09-01

    Purpose: The aim of this study was to develop a rapid and reproducible technique for prone positioning and to compare dose-volume indices in prone and supine positions. Methods and Materials: Eighteen patients underwent computed tomography imaging for radiotherapy planning in prone and supine position. Experience was gained in the first eight patients, which lead to modifications of the Horizon prone breast board (Civco Medical Solutions, Orange City, Iowa, USA) and the patient setup technique. A unilateral breast holder (U-BH) was developed (Van de Velde, Schellebelle, Belgium) to retract the contralateral breast away from the treated breast. The technique was then applied to an additional 10 patients. The setup precision was evaluated using daily cone-beam CT. Results: Modifications to the breast board were made to secure a prone-lateral rather then a pure prone position. We evolved from a classical setup using laser marks on the patients' body to a direct breast setup using marks on the breast only. The setup precision of the direct positioning procedure with the modified breast board and the U-BH is comparable to supine setup data in the literature. Dose-volume indices for heart and lung show significantly better results for prone than for supine position, and dose homogeneity within the treated breast did not differ according to the treatment position. Conclusions: The setup precision of our prone-lateral positioning technique is comparable to supine data in literature. Our data show the advantage of prone radiotherapy to spare the lung and heart. Further research is necessary to reduce the duration of prone setup.

  3. Prostate cancer detection rate in patients with obstructive voiding symptoms by sextant biopsy: preliminary results.

    PubMed

    Kiknavelidze, K; Tsintsadze, O; Goguadze, M; Pertia, A; Managadze, L

    2006-04-01

    To evaluate the effectiveness of a laterally directed sextant biopsy in the group of high volume prostate patients with obstructive voiding symptoms and suspected of prostate cancer. Biopsy was performed in 197 men (age: median 63 years, range 47 to 82 years) because of elevated PSA and/or abnormality in digital rectal examinations (DRE). In most cases, a markedly enlarged prostate was noted: the mean prostate volume was 79,9+/-38,5 cc, and in 73% of the cases, the volume of the prostate was >50 cc. Prostate cancer was diagnosed in 56 of 197 cases (28,4%). The prostate cancer detection rate among patients with a prostate volume of 80cc (high volume) were 39,6%, 32,8% and 18,6%, respectively. Our results showed that the laterally directed sextant biopsy with the overall detection rate as high as 28,4% and very low complications is an effective method for the detection of prostate cancer among the suspected patients with obstructive voiding symptoms and markedly enlarged prostates.

  4. [Effectiveness of mesoglycan therapy in patients with ischemia of the lower limbs. Preliminary results of a new therapeutic protocol].

    PubMed

    Raso, A M; Maggio, D; Trogolo, M; Rispoli, P; Sandrone, N; Pezzuto, D; Bellan, A; Melloni, C D

    1997-01-01

    Mesoglycan is a natural glycosaminoglycans preparation, with antithrombotic and pro-fibrinolytic activities, which has been shown to be clinically effective in a number of vascular atherosclerotic disorders with thrombotic risk. In the present investigation we studied the effect of mesoglycan in patients with acute episodes of relative lower limb ischemia (Stage IIb according to Leriche-Fontaine classification) coming to our observation. Mesoglycan was administered according to the following schedule: a 10-days period of endovenous mesoglycan (90 mg/day), given in day-hospital regimen, followed by a 20-days period of oral mesoglycan (100 mg/day). The treatment schedule was repeated for two months and then patient continued with oral mesoglycan. We present the preliminary results obtained on 36 patients which were followed for a mean period of 12 months. From February 1995 thirty-six patients, 24 males and 12 females, aged between 45 and 83 years (mean +/- SD: 69.8 +/- 7.5) coming to our observation for acute relative lower limb ischemia were enrolled. At baseline, the diagnosis was Fontaine's IIb stage (walking distance < or = 200 m) in all patients, 17 patients presenting walking distance < 100 m. After 3 and 6 months of mesoglycan treatment a significant improvement of symptoms and signs was observed in all patients but one. At the end of the 6-months period, 29 patients (81% of the study population) became to a Fontaine's IIa degree, with a significant increase in walking distance (in 70% three times their basal value) and improvement of symptoms and recovery time. After treatment, Winsor Index was not significantly modified. Similar results were obtained after 12 months of follow-up. During the study period only one patient included in the trial needed surgical revascularisation. The administration of mesoglycan was well tolerated, with only minor complaints in two patients (one case of headache and one of diarrhea). During the endovenous administration of

  5. Effectiveness of femoral nerve selective block in patients with spasticity: preliminary results.

    PubMed

    Albert, Thierry A; Yelnik, Alain; Bonan, Isabelle; Lebreton, Frederique; Bussel, Bernard

    2002-05-01

    To determine if the vastus intermedius nerve can be blocked by using surface coordinates and to measure the effects of selective nerve block on quadriceps spasticity and immediate gait. Case series. Physical medicine and rehabilitation department of a university hospital. Twelve patients with hemiplegia disabled by quadriceps overactivity. Anesthesic block of the vastus intermedius by using surface coordinates, femoral nerve stimulation before and after block, and surface electrodes recording of the amplitude of the maximum direct motor response of each head of the quadriceps. Assessment of spasticity, voluntary knee extension velocity, speed of gait, and knee flexion when walking. To be effective, the puncture point (.29 of thigh length and 2cm lateral) had to be slightly modified to 1cm laterally from a point situated at 0.2 of the thigh length. A selective block of the vastus intermedius could not be achieved, but a block of the vastus lateralis was always achieved, twice associated with a block of the vastus intermedius, resulting in decreased quadriceps spasticity, no changes in gait parameters, no decrease in voluntary knee extension velocity, and subjective improvement in gait for 3 patients. Selective block of the vastus lateralis with or without the vastus intermedius can be achieved by using surface coordinates without any dramatic effect on knee extension velocity, and it could be useful for phenol or alcohol block or surgical neurotomy. Copyright 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation

  6. Preliminary Screening Results of Fabry Disease in Kidney Transplantation Patients: A Single-Center Study.

    PubMed

    Yılmaz, M; Uçar, S K; Aşçı, G; Canda, E; Tan, F A; Hoşcoşkun, C; Çoker, M; Töz, H

    2017-04-01

    Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by the deficiency of alfa-galactosidase A (AGALA) and leads to progressive impairment of renal function in almost all male patients and in a significant proportion of female patients. FD is underdiagnosed or even misdiagnosed in patients undergoing kidney transplantation. We initiated a selective screening study for FD among kidney transplant patients in our center. In this study, 1095 male and female patients were included. Dried blood samples on Guthrie papers were used to analyze galactosidase A enzyme for male patients. Genetic analyses were performed in all female and male patients with low enzyme activity. In total, 648 female and 447 male patients with functioning grafts were evaluated. Among 1095 patients, 5 male patients had AGALA activity below threshold and 3 female patients had galactosidase alpha gene DNA variations. One male patient had a disease-causing mutation. The other 4 patients had polymorphisms causing low enzyme activity. All the 3 female patients had mutations that were associated with FD according to Human Gene Mutation Database (ID: CM025441). In contrast, these mutations were reported as unknown clinical significance in Clinvar (rs149391489). The patients with clinical findings suggesting FD were planned to be analyzed for Lyso Gb3. In our selective screening study, 8 variations were found among 1095 kidney transplantation patients, which needs further investigation to determine causes of FD. Clinical findings, physical examination, and family history are also necessary to evaluate the genetic changes as a mutation in this selected population.

  7. Manual Khalifa Therapy in Patients with Completely Ruptured Anterior Cruciate Ligament in the Knee: First Preliminary Results from Thermal Imaging

    PubMed Central

    Litscher, Gerhard; Ofner, Michael; Litscher, Daniela

    2013-01-01

    Background: This preliminary publication describes acute temperature effects after manual Khalifa therapy. Aims: The goal of this study was to describe temperature distribution and the effects on surface temperature of the knees and feet in patients with completely ruptured anterior cruciate ligament before and immediately after the manual therapy. Materials and Methods: Ten male patients were investigated with thermal imaging. An infrared camera operating at a wavelength range of 7.5-13 μm was used. Temperature was analyzed at three locations on both knees and in addition on both feet. Results: The study revealed that baseline temperature of the injured knee differed from that of the untreated control knee. After the therapy on the injured knee, the surface temperature was significantly increased on both knees (injured and control). There were no significant changes in the temperature of the feet. Conclusions: Further studies using continuous thermal image recording may help to explain the details concerning the temperature distribution. PMID:24083223

  8. Added value of SPECT/CT in patients suspected of having bone infection: preliminary results.

    PubMed

    Horger, Marius; Eschmann, Susanne Martina; Pfannenberg, Christina; Storek, Dieter; Vonthein, Reinhard; Claussen, Claus D; Bares, Roland

    2007-04-01

    We evaluated the contribution of SPECT/CT as an adjunct to combined three-phase bone scintigraphy (planar and SPECT) for diagnosing and localizing bone infection. Subsequently, the diagnostic performance of SPECT/CT was compared to visual fusion of SPECT with data of additional CT, X-ray, or MRI studies (SPECT + CT/X-ray/MRI). Thirty-one patients suspected of bone infection, presenting pathological findings on triple-phase bone scintigraphy, underwent additional SPECT/CT. The SPECT/CT-technology combines the acquisition of SPECT and CT data with the same imaging device enabling perfect overlay of anatomical and functional images. (99m)Tc-DPD was used as radiopharmaceutical in all patients. For data analysis findings of bone scintigraphy (planar scans as well as SPECT) were categorized as positive, negative, or equivocal for the presence of osteomyelitis. In a second step, they were compared with SPECT/CT and SPECT + CT/X-ray/MRI with respect to localization and classification of lesions. Validation was achieved by surgery, biopsy, or by clinical follow up over at least 9 months including microbiological and radiological findings. Three-phase bone scan (incl. SPECT) correctly classified 7 lesions as positive and 11 lesions as negative for osteomyelitis. Six scans were interpreted false positive, two false negative, and five as equivocal. Rating the latter as positive for osteomyelitis, sensitivity of bone scan was (78%), specificity (50%). SPECT/CT was true positive in 7 patients, and true negative in 19. There were two false positive and two false negative findings, one scan was equivocal (sensitivity 78%, specificity 86%). Definition of anatomical localization of inflammatory foci was much easier by SPECT/CT due to better depiction of underlying anatomical details. SPECT + CT/X-ray/MRI yielded the highest sensitivity (100% compared to 78% of SPECT/CT), if equivocal findings (5/31 compared to 1/31 for SPECT/CT) are rated as true positive for osteomyelitis. Among

  9. Cancer patients' questions and concerns expressed in an online nurse-delivered mail service: preliminary results.

    PubMed

    Andersen, Trine; Ruland, Cornelia M

    2009-01-01

    Internet-based online patient-nurse communication (OPNC) services can constitute an important opportunity to support patients to manage their illness between treatment and rehabilitation while being at home. We explored the content of messages sent by prostate and breast cancer patients to an OPNC service to identify symptoms, problems, concerns and information needs expressed in these messages. Using qualitative content analyses we examined 276 messages sent from 38 breast and 22 prostate cancer patients during 15 months. Two main themes emerged: Concerns about physical symptoms and treatment side effects; and worries and questions about treatment and follow up. Analyses showed that cancer patients have many serious unanswered questions and concerns that can create considerable uncertainty and anxiety. An OPNC service can to a great extent meet patients' need for advice and information and thus be an important health care supplement that can improve quality of care.

  10. Home Palliative Care for Patients with Advanced Chronic Kidney Disease: Preliminary Results

    PubMed Central

    Teruel, José L.; Rexach, Lourdes; Burguera, Victor; Gomis, Antonio; Fernandez-Lucas, Milagros; Rivera, Maite; Diaz, Alicia; Collazo, Sergio; Liaño, Fernando

    2015-01-01

    Healthcare for patients with advanced chronic kidney disease (ACKD) on conservative treatment very often poses healthcare problems that are difficult to solve. At the end of 2011, we began a program based on the care and monitoring of these patients by Primary Care Teams. ACKD patients who opted for conservative treatment were offered the chance to be cared for mainly at home by the Primary Care doctor and nurse, under the coordination of the Palliative Care Unit and the Nephrology Department. During 2012, 2013, and 2014, 76 patients received treatment in this program (mean age: 81 years; mean Charlson age-comorbidity index: 10, and mean glomerular filtration rate: 12.4 mL/min/1.73 m2). The median patient follow-up time (until death or until 31 December 2014) was 165 days. During this period, 51% of patients did not have to visit the hospital’s emergency department and 58% did not require hospitalization. Forty-eight of the 76 patients died after a median time of 135 days in the program; 24 (50%) died at home. Our experience indicates that with the support of the Palliative Care Unit and the Nephrology Department, ACKD patients who are not dialysis candidates may be monitored at home by Primary Care Teams. PMID:27417813

  11. Home Palliative Care for Patients with Advanced Chronic Kidney Disease: Preliminary Results.

    PubMed

    Teruel, José L; Rexach, Lourdes; Burguera, Victor; Gomis, Antonio; Fernandez-Lucas, Milagros; Rivera, Maite; Diaz, Alicia; Collazo, Sergio; Liaño, Fernando

    2015-10-28

    Healthcare for patients with advanced chronic kidney disease (ACKD) on conservative treatment very often poses healthcare problems that are difficult to solve. At the end of 2011, we began a program based on the care and monitoring of these patients by Primary Care Teams. ACKD patients who opted for conservative treatment were offered the chance to be cared for mainly at home by the Primary Care doctor and nurse, under the coordination of the Palliative Care Unit and the Nephrology Department. During 2012, 2013, and 2014, 76 patients received treatment in this program (mean age: 81 years; mean Charlson age-comorbidity index: 10, and mean glomerular filtration rate: 12.4 mL/min/1.73 m²). The median patient follow-up time (until death or until 31 December 2014) was 165 days. During this period, 51% of patients did not have to visit the hospital's emergency department and 58% did not require hospitalization. Forty-eight of the 76 patients died after a median time of 135 days in the program; 24 (50%) died at home. Our experience indicates that with the support of the Palliative Care Unit and the Nephrology Department, ACKD patients who are not dialysis candidates may be monitored at home by Primary Care Teams.

  12. Treatment of Stress Urinary Incontinence in Neurological Patients With an Injectable Elastomer Prosthesis: Preliminary Results

    PubMed Central

    Citeri, Marco; Zanollo, Lucia; Guerrer, Chiara; Rizzato, Luigi; Frediani, Luca; Iselin, Christophe; Spinelli, Michele

    2017-01-01

    Many treatment options for stress urinary incontinence are difficult to apply to neurological patients. Urolastic is a new agent that is primarily indicated for women with mild stress urinary incontinence or men after prostate surgery. In this report, we present a series of 5 cases describing the first use of Urolastic to treat neurological patients. All patients were evaluated with a voiding diary and the use of auxiliary devices as the main indicators of continence. The median operative time was 30.8 minutes, and no complications were observed. Of the 5 patients, 4 reported improved incontinence: 2 switched from diapers to small pads, while the other 2 patients were able to discontinue urinary condom use. The only instance of treatment failure occurred in a patient with a low-compliance bladder. The advantages of this procedure appear to include a soft-cuff effect, reversibility, and minimal invasiveness. However, a future randomized study would be necessary to validate this treatment option. PMID:28361514

  13. Maxillary sinus floor augmentation using blood without graft material. Preliminary results in 10 patients.

    PubMed

    de Oliveira, Greison R; Olate, Sergio; Cavalieri-Pereira, Lucas; Pozzer, Leandro; Asprino, Luciana; de Moraes, Marcio; de Albergaría-Barbosa, Jose Ricardo

    2013-10-01

    The maxillary sinus lift is recognized and stable, and there have been different innovations to optimize the technique. The aim of this study was to investigate the maxillary sinus lift technique with the use of a blood clot and without the use of a bone graft. Ten patients were recruited for a unilateral sinus lift; patients without sinus pathology or other contraindication were selected. The maxillary sinus was accessed conventionally under local anesthesia followed by an osteotomy and a 1-cm(2) bony window access. The sinus membrane was detached and the window was repositioned above and stabilized with a 12- or 14-mm osteosynthesis screw introduced through the alveolar ridge. Dental implants were installed in the second surgical stage. Standardized panoramic radiographic checks were performed at every stage. Seven completely edentulous patients and 3 partially dentate patients were treated surgically. From the first to the second surgery, a bone gain of 2.37 mm was obtained, although loss of bone height was observed in 1 completely edentulous patient. In 7 patients, it was not possible to install the implants owing to insufficient bone height or inadequate bone quality. The protocol used in this investigation failed in the bone increase required for implant installation. Copyright © 2013 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  14. Evaluation of subclinical atherosclerosis in migraine patients by ultrasound radiofrequency data technology: preliminary results.

    PubMed

    Güneş Tatar, İdil; Ergun, Onur; Çeltikçi, Pınar; Kurt, Aydın; Yavaşoğlu, Neşe; Birgi, Erdem; Tatar, Tolga; Hekimoğlu, Baki

    2016-07-01

    Migraine is a headache disorder affecting approximately 12% of the population, predominantly female individuals. Migraine has been associated with vascular events such as stroke and cardiovascular disease. The close connection between these vascular disorders and atherosclerosis is well known. Carotid artery intima-media thickness (CAIMT) is a marker for detection of subclinical atherosclerosis. The present study is an analysis of the presence of subclinical atherosclerosis in migraine patients. CAIMT was evaluated in 25 female migraine patients and 27 female controls using innovative ultrasound (US) radiofrequency (RF) data technology. Mann-Whitney U test was used to compare measurements in patient and control groups. There was a statistically significant difference between mean CAIMT of migraine patients and control group (p<0.005): mean CAIMT was 701±114 µm in migraine patients and 400±64 µm in control group. Migraine patients are more prone to atherosclerosis compared to healthy individuals. CAIMT measurement with sonography can be utilized in follow-up to detect subclinical atherosclerosis.

  15. Automatic, computer-based speech assessment on edentulous patients with and without complete dentures - preliminary results.

    PubMed

    Stelzle, F; Ugrinovic, B; Knipfer, C; Bocklet, T; Nöth, E; Schuster, M; Eitner, S; Seiss, M; Nkenke, E

    2010-03-01

    Dental rehabilitation of edentulous patients with complete dentures includes not only aesthetics and mastication of food, but also speech quality. It was the aim of this study to introduce and validate a computer-based speech recognition system (ASR) for automatic speech assessment in edentulous patients after dental rehabilitation with complete dentures. To examine the impact of dentures on speech production, the speech outcome of edentulous patients with and without complete dentures was compared. Twenty-eight patients reading a standardized text were recorded twice - with and without their complete dentures in situ. A control group of 40 healthy subjects with natural dentition was recorded under the same conditions. Speech quality was evaluated by means of a polyphone-based ASR according to the percentage of the word accuracy (WA). Speech acceptability assessment by expert listeners and the automatic rating of the WA by the ASR showed a high correlation (corr = 0.71). Word accuracy was significantly reduced in edentulous speakers (55.42 +/- 13.1) compared to the control group's WA (69.79 +/- 10.6). On the other hand, wearing complete dentures significantly increased the WA of the edentulous patients (60.00 +/- 15.6). Speech production quality is significantly reduced after complete loss of teeth. Reconstitution of speech production quality is an important part of dental rehabilitation and can be improved for edentulous patients by means of complete dentures. The ASR has proven to be a useful and easily applicable tool for automatic speech assessment in a standardized way.

  16. Preliminary Results of Whole Brain Radiotherapy With Concurrent Trastuzumab for Treatment of Brain Metastases in Breast Cancer Patients

    SciTech Connect

    Chargari, Cyrus; Idrissi, Hind Riahi; Pierga, Jean-Yves; Bollet, Marc A.; Dieras, Veronique; Campana, Francois; Cottu, Paul; Fourquet, Alain; Kirova, Youlia M.

    2011-11-01

    Purpose: To assess the use of trastuzumab concurrently with whole brain radiotherapy (WBRT) for patients with brain metastases from human epidermal growth factor receptor-2-positive breast cancer. Methods and Materials: Between April 2001 and April 2007, 31 patients with brain metastases from human epidermal growth factor receptor-2-positive breast cancer were referred for WBRT with concurrent trastuzumab. At brain progression, the median age was 55 years (range, 38-73), and all patients had a performance status of 0-2. The patients received trastuzumab 2 mg/kg weekly (n = 17) or 6 mg/kg repeated every 21 days (n = 14). In 26 patients, concurrent WBRT delivered 30 Gy in 10 daily fractions. In 6 patients, other fractionations were chosen because of either poor performance status or patient convenience. Results: After WBRT, radiologic responses were observed in 23 patients (74.2%), including 6 (19.4%) with a complete radiologic response and 17 (54.8%) with a partial radiologic response. Clinical responses were observed in 27 patients (87.1%). The median survival time from the start of WBRT was 18 months (range, 2-65). The median interval to brain progression was 10.5 months (range, 2-27). No Grade 2 or greater acute toxicity was observed. Conclusion: The low toxicity of trastuzumab concurrently with WBRT should probably not justify delays. Although promising, these preliminary data warrant additional validation of trastuzumab as a potential radiosensitizer for WBRT in brain metastases from breast cancer in the setting of a clinical trial.

  17. Nivolumab in Patients With Relapsed or Refractory Hematologic Malignancy: Preliminary Results of a Phase Ib Study.

    PubMed

    Lesokhin, Alexander M; Ansell, Stephen M; Armand, Philippe; Scott, Emma C; Halwani, Ahmad; Gutierrez, Martin; Millenson, Michael M; Cohen, Adam D; Schuster, Stephen J; Lebovic, Daniel; Dhodapkar, Madhav; Avigan, David; Chapuy, Bjoern; Ligon, Azra H; Freeman, Gordon J; Rodig, Scott J; Cattry, Deepika; Zhu, Lili; Grosso, Joseph F; Bradley Garelik, M Brigid; Shipp, Margaret A; Borrello, Ivan; Timmerman, John

    2016-08-10

    Cancer cells can exploit the programmed death-1 (PD-1) immune checkpoint pathway to avoid immune surveillance by modulating T-lymphocyte activity. In part, this may occur through overexpression of PD-1 and PD-1 pathway ligands (PD-L1 and PD-L2) in the tumor microenvironment. PD-1 blockade has produced significant antitumor activity in solid tumors, and similar evidence has emerged in hematologic malignancies. In this phase I, open-label, dose-escalation, cohort-expansion study, patients with relapsed or refractory B-cell lymphoma, T-cell lymphoma, and multiple myeloma received the anti-PD-1 monoclonal antibody nivolumab at doses of 1 or 3 mg/kg every 2 weeks. This study aimed to evaluate the safety and efficacy of nivolumab and to assess PD-L1/PD-L2 locus integrity and protein expression. Eighty-one patients were treated (follicular lymphoma, n = 10; diffuse large B-cell lymphoma, n = 11; other B-cell lymphomas, n = 10; mycosis fungoides, n = 13; peripheral T-cell lymphoma, n = 5; other T-cell lymphomas, n = 5; multiple myeloma, n = 27). Patients had received a median of three (range, one to 12) prior systemic treatments. Drug-related adverse events occurred in 51 (63%) patients, and most were grade 1 or 2. Objective response rates were 40%, 36%, 15%, and 40% among patients with follicular lymphoma, diffuse large B-cell lymphoma, mycosis fungoides, and peripheral T-cell lymphoma, respectively. Median time of follow-up observation was 66.6 weeks (range, 1.6 to 132.0+ weeks). Durations of response in individual patients ranged from 6.0 to 81.6+ weeks. Nivolumab was well tolerated and exhibited antitumor activity in extensively pretreated patients with relapsed or refractory B- and T-cell lymphomas. Additional studies of nivolumab in these diseases are ongoing. © 2016 by American Society of Clinical Oncology.

  18. Malignancies in the AIDS patient: natural history, treatment strategies, and preliminary results.

    PubMed

    Longo, D L; Steis, R G; Lane, H C; Lotze, M T; Rosenberg, S A; Preble, O; Masur, H; Rook, A H; Fauci, A S; Jacob, J

    1984-01-01

    Almost 40% of the 3000 US patients with acquired immunodeficiency syndrome (AIDS) have a malignancy at the time of reporting, and the incidence of AIDS patients who develop a malignancy during the course of the disease may be 65-70%. 2 types of malignancies have been noted with increased frequency in AIDS victims: Kaposi's sarcoma and malignant lymphomas. About 35% of all AIDS patients and 50% of homosexual or bisexual victims have developed Kaposi's sarcoma, and those with coincident opportunistic infection have 2.5 times the mortality of those without such infection. There are 2 essential features to the histopathology of Kaposi's sarcoma: 1) vascular proliferation and 2) spindle-shaped neoplastic cells in a network of reticulin fibers that appear to be of endothelial origin. The treatment of the epidemic form of Kaposi's sarcoma has not been successful, and the projected 2-year survival is only 30%. The causes of death in the majority of such patients are overwhelming opportunistic infections, especially cytomegalovirus and Pneumocystis carinii, and irreversible cachexia and wasting. Interferon therapy has had a beneficial effect in patients with disease limited to skin, with T4/T8 ratios over 0.5, and without a prior history of opportunistic infection; however, there is no evidence that interferon exerts any beneficial effects on the underlying immune defects. An aggressive 6-drug combination chemotherapy regimen has been tried on patients whose tumors appeared to be life-threatening and was effective in controlling the Kaposi's sarcoma, but again did not appreciably alter immune parameters. Several other approaches to the treatment of epidemic Kaposi's sarcoma are under evaluation, including gamma interferon, interleukin-2, and plasmapheresis. Patients who develop malignant lymphomas require combined treatment with central nervous system radiation and systemic combination chemotherapy. There is no evidence that the antitumor responses obtained in AIDS

  19. Autologous bone marrow mononuclear cells transplant in patients with critical leg ischemia: preliminary clinical results.

    PubMed

    Li, Min; Zhou, Hua; Jin, Xing; Wang, Mo; Zhang, Shiyi; Xu, Lei

    2013-10-01

    Stem cell transplant can induce vasculogenesis and improve the blood supply to an ischemic region, offering hope for chronic lower extremity ischemic diseases. Bone marrow mononuclear cells are one of the sources for stem cell transplants. We sought to observe the safety and efficacy of autologous bone marrow mononuclear cells transplant for treating critical limb ischemia. Eligible patients were randomized 1:1 to receive placebo (0.9% NaCl) or 1 × 107 piece/mL bone marrow mononuclear cell transplant. For 6 months, patients' skin ulcers, ankle-brachial index, and rest pain were examined and recorded before and after treatment. Six months after the bone marrow mononuclear cells transplant, clinical symptoms like rest pain and skin ulcers gradually abated (P < .05). Ankle-brachial index also increased after the transplant (P < .01). Autologous bone marrow mononuclear cells transplant for treatment of patients with chronic limb ischemia is safe, effective, and feasible.

  20. The diurnal profile of melatonin during delirium in elderly patients--preliminary results.

    PubMed

    Piotrowicz, Karolina; Klich-Rączka, Alicja; Pac, Agnieszka; Zdzienicka, Anna; Grodzicki, Tomasz

    2015-12-01

    Delirium is an acute-onset syndrome that exacerbates patients' condition and significantly increases consequential morbidity and mortality. There is no comprehensive, cellular and tissue-level, pathophysiological theory. The melatonin hormone imbalance has been shown to be linked to circadian rhythms, sleep-wake cycle disturbances, and delirium incidence. There has been relatively little research about melatonin in delirium, and there has been no such study done in the group of elderly patients of a general medicine ward yet. The aim of our study was to compare melatonin hormone concentration in relation to the presence of delirium in elderly patients hospitalized in the general medicine ward. Blood samples were collected four times a day for two days (at 12:00, 18:00, 00:00 and 6:00), on the day when delirium was diagnosed and 72 h after the delirium resolution. Delirium was diagnosed with the Confusion Assessment Method and the criteria of the Diagnostic and Statistic Manual of Mental Disorders, 4th Revision. The mean age of 30 patients (73.3% women) was 86.5 ± 5.2 years. Delirium was diagnosed most often on the second and third day of hospitalization. A lot of predisposing and precipitating factors for delirium were identified. There was a significant difference in the melatonin hormone concentration measurement at 12:00 when patients had acute delirium and after its resolution [18.5 (13.8, 27.5) vs 12.9 (9.8, 17.8), p<0.01]. Different patterns of the melatonin hormone concentration were shown in analyses in the subgroups defined according to the patients' diagnosis of dementia. We found that the delirium recovery was, in fact, associated with the alteration of the daily profile of melatonin. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. The MUNU experiment : preliminary results

    NASA Astrophysics Data System (ADS)

    Busto, J.; MUNU Collaboration

    2000-06-01

    The MUNU collaboration has built a detector to study overlineνe - e - scattering at low energy. From the results we expect to increase the sensitivity to the neutrino magnetic moment. The detector used, a 1 m 3 T.P.C. surrounded by an anti-Compton scintillator, is running at the Bugey nuclear plant. Some preliminary results will be presented in the following.

  2. Intestinal microbiota in adult patients with Short Bowel Syndrome: Preliminary results from a pilot study.

    PubMed

    Boccia, Stefania; Torre, Ida; Santarpia, Lidia; Iervolino, Carmela; Del Piano, Concetta; Puggina, Anna; Pastorino, Roberta; Dragic, Miroslav; Amore, Rosarita; Borriello, Tonia; Palladino, Raffaele; Pennino, Francesca; Contaldo, Franco; Pasanisi, Fabrizio

    2016-10-01

    Intestinal bacterial flora plays a central role in human intestinal health and disease. Short Bowel Syndrome (SBS), a clinical condition deriving from extensive bowel resections, influence intestinal microbiota (IM) composition in order to reach a new metabolic balance. Little is known about IM in adult patients after wide intestinal resections. Fecal samples from 12 SBS patients and 16 controls were analyzed in their microbial profile by using both culture-dependent method and quantitative Real-Time PCR (qRT-PCR). The two methods revealed significant lower concentrations of Bacteroidetes (p-value = .02), Firmicutes (p-value = .05), Bifidobacterium (p-value < .01), and Methanobrevibacter Smithii (p-value = .04) in SBS patients than controls. The significantly different fecal microbiome in SBS patients compared with healthy controls could open new perspectives on the care of their intestinal functions. Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

  3. Correction of Retrograde Ejaculation in Patients with Diabetes Mellitus Using Endourethral Collagen Injection: Preliminary Results.

    PubMed

    Kurbatov, Dmitry; Russo, Giorgio Ivan; Galstyan, G R; Rozhivanov, Roman; Lepetukhin, Alexander; Dubsky, Sergey; Shwartz, Y G; Cimino, Sebastiano; Morgia, Giuseppe; Sansalone, Salvatore

    2015-11-01

    Diabetic neuropathy secondary to diabetes mellitus type 1 (DM1) is responsible for retrograde ejaculation (RE) in 5-18% of cases. Medical treatment of RE is based either on increasing the sympathetic tone of the bladder or on decreasing the parasympathetic activity. However, the onset of side effects and the lack of response should be considered. The aim of this study was to analyze long-term outcome of endourethral injection of volume-forming material (VFM) of collagen type 2 into bladder neck submucosa in patients with RE secondary to DM1. Twenty-four patients with complete RE refractory to imipramine and DM1 were included in the study. Patients were single-blinded randomized according to a computer-generated random sequence with a 1:1 ratio in two treatment groups, namely group A (endourethral collage type 2 injection) and group B (endourethral saline water injection). New technique includes an endoscopic injection of VFM such as collagen (Correcting MIT®, Ltd. minimally invasive technologies, Moscow, Russia) into bladder neck submucosa. Primary endpoint of the study was the reduction of semen antegrade volume (mL). Secondary endpoints were considered as the changes of antegrade count (millions/mL), antegrade total motility (%), antegrade progressive motility (%), State-Trait Anxiety Inventory, Beck Depression Questionnaire and International Index of Erectile Function (IIEF-5). Pregnancy rate was calculated in each group. Twenty-three patients completed the study. In group A, significant differences from baseline to 12 months were observed relative to antegrade volume (mL) (mean difference: 0.71, P < 0.05), antegrade count (millions/mL) (mean difference: 45.6, P < 0.05), antegrade total motility (%) (mean difference: 15.4, P < 0.05) and antegrade progressive motility (%) (mean difference: 8.4, P < 0.05). In group A, we observed significant differences in terms State-Trait Anxiety Inventory (mean difference: -20.5, P < 0.05) and Beck Depression Inventory (mean

  4. An economic evaluation of implant treatment in edentulous patients-preliminary results.

    PubMed

    Zitzmann, Nicola U; Sendi, Pedram; Marinello, Carlo P

    2005-01-01

    Edentulous patients with denture problems benefit from implant treatment with overdenture prostheses. The aim of this prospective study was to investigate a method of analyzing cost effectiveness in dentistry. As an example, overdenture treatment with two or four implants was compared to the conventional complete denture (CD). In a self-selected trial, 20 patients each were treated with implant-retained overdentures (two implants, IRET), implant-supported overdentures (four implants, ISUP), or CDs (control group) in the edentulous mandible. A cost-effectiveness analysis was performed from the patient's perspective, with a time horizon of 6 months. Direct health-care costs were calculated in Swiss Francs (in 2000), and effects were defined as improvements in perceived chewing ability compared with the baseline value before treatment (measured on a VAS). Point estimates for mean incremental cost-effectiveness ratios were complemented with cost-effectiveness acceptability curves to account for uncertainties associated with costs and effects. Mean incremental costs were CHF 4,329 (IRET-CD), CHF 13,360 (ISUP-CD), and CHF 9,031 (ISUP-IRET); these cost differences were all statistically significant. The mean incremental effects at 6 months were 19% (IRET-CD), 23% (ISUP-CD), and 4% (ISUP-IRET). Incremental cost-effectiveness ratios were CHF 228 (IRET-CD), CHF 581 (ISUP-CD), and CHF 2,258 (IRET-ISUP) per percentage increase in chewing ability. From an economic point of view, IRETs were more attractive than ISUPs. The latter were associated with a statistically significant improvement in perceived chewing ability compared to CDs, but at substantially higher costs.

  5. Preliminary results after upper cervical chiropractic care in patients with chronic cerebro-spinal venous insufficiency and multiple sclerosis.

    PubMed

    Mandolesi, Sandro; Marceca, Giuseppe; Moser, Jon; Niglio, Tarcisio; d'Alessandro, Aldo; Ciccone, Matteo Marco; Zito, Annapaola; Mandolesi, Dimitri; d'Alessandro, Alessandro; Fedele, Francesco

    2015-01-01

    The aim of the study is to evaluate the clinical and X-ray results of the Upper Cervical Chiropractic care through the specific adjustments (corrections) of C1-C2 on patients with chronic venous cerebral-spinal insufficiency (CCSVI) and multiple sclerosis (MS). We studied a sample of 77 patients before and after the Upper Cervical Chiropractic care, and we analyzed: A) The change of the X-ray parameters; B) The clinical results using a new set of questions. The protocol of the C1- C2 upper Cervical Chiropractic treatment, specific for these patients, lasts four months. From a haemodynamic point of view we divided the patients in 3 types: Type 1 - purely vascular with intravenous alterations; Type 2 - "mechanical" with of external venous compressions; Type 3 - mixed. We found an improvement in all kinds of subluxations after the treatment with respect to the pre-treatment X-ray evaluation, with a significant statistical difference. The differences between the clinical symptoms before and after the specific treatment of C1-C2 are statistically significant with p<0.001 according to the CHI-Square test revised by Yates. The preliminary X-ray and clinical improvements of the Upper Cervical Chiropractic corrections on C1- C2 on these patients with CCSVI and MS encourage us to continue with our studies. We believe that the Upper Cervical correction on C1-C2 could be the main non-invasive treatment of the CCSVI mechanical type in patients with MS. Further studies are required to evaluate the correlation between the Upper Cervical Chiropractic correction on C1-C2 on the cerebral venous drainage and the cerebro-spinal fluid.

  6. [Overexpression of laminine-5( LN-5) in peritoneal lavage of colorectal cancer patients preliminary results].

    PubMed

    Volpi, A; D'Elia, G; Pannarale, O C; Di Gennaro, F; Guida, P; Martinelli, E; Kavvadias, A; Balducci, G; Ialongo, P; Panebianco, A; De Luca, M; Fabiano, G; Palasciano, N

    2011-01-01

    Recent studies show that interaction between LN (heterotrimeric protein formed by a3/b3/g2 chains) and cancer cells plays an important role in tumor invasion, also in colorectal cancer. The overall survival was significantly worse in patients with free peritoneal cancer cells(FPTCs): detection of FPTCs after curative surgery is a challenge, because could improve staging and prognosis. Peritoneal citology is the current standard procedure with very low sensivity. We aimed to study the expression of LN5 in the peritoneal lavage of colorectal cancer pts and in controls with semiquantitative reverse trancriptase-polymerase chain reaction (RT-PCR). LN-5 overexpression was evaluated observing PCR- products intensity at electrophoresis: high intensity is correlated to overexpression. Pre and post-operative peritoneal lavages of 30 pts with colorectal cancer (13M;17F), with median age of 69 (58-84), and of 10 controls, were analyzed by conventional cytology and a semiquantitative RT-PCR. No cancer pts showed pre/postoperative negative cytology and did not express LN-5. In cancer pts. cytology was positive in 2 pts in pre/postoperative lavage. LN-5 overexpression was observed in 56,6% preoperatively and in 76,6% postoperatively. LN-5 g 2 chain was most frequent chain. Our study suggests a relationship between LN-5 and FPTCs, as shown by the low expression of lamimine in controls. LN-5 could be a useful marker to identify a subgroup of early-stage patients at increased risk of recurrence; moreover, mortality seems to correlated to LAMB3 chain. The diagnostic accuracy could be improved by using a quantitative RT-PCR or western-blot and detecting serum laminine. Finally, to validate these findings a larger number of pts with follow-up study is required.

  7. Assessment of hemodynamics of intracranial aneurysms using Doppler optical coherence tomography in patient specific phantoms: preliminary results (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Ramjist, Joel M.; Jivraj, Jamil; Barrows, Dexter; Vuong, Barry; Wong, Ronnie; Yang, Victor X. D.

    2017-02-01

    Intracranial aneurysms affect a large number of individuals every year. Changes to hemodynamics are thought to be a crucial factor in the initial formation and enlargement of intracranial aneurysms. Previously, surgical clipping - an open an invasive procedure, was the standard of care. More recently, minimally invasive, catheter based therapies, specifically stenting and coiling, has been employed for treatment as it is less invasive and poses fewer overall risks. However, these treatments can further alter hemodynamic patterns of patients, affecting efficacy and prognosis. Doppler optical coherence tomography (DOCT) has shown to be useful for the evaluation of changes to hemodynamic patterns in various vascular pathologies, and intravascular DOCT may provide useful insight in the evaluation and changes to hemodynamic patterns before and during the treatment of aneurysms. In this study, we present preliminary results of DOCT imaging used in three patient-specific aneurysm phantoms located within the Circle of Willis both pre and post-treatment. These results are compared with computational fluid dynamics (CFD) simulations and high-speed camera imaging for further interpretation and validation of results.

  8. Vesselplasty: a new minimally invasive approach to treat pathological vertebral fractures in selected tumor patients - preliminary results.

    PubMed

    Klingler, J-H; Sircar, R; Deininger, M H; Scheiwe, C; Kogias, E; Hubbe, U

    2013-04-01

    To evaluate the effectiveness and safety of percutaneous vesselplasty in pathological vertebral fractures of the thoracolumbar spine in selected tumor patients. Eleven pathological vertebral fractures in nine patients were treated with vesselplasty (Vessel-X®, MAXXSPINE). Nine of eleven vertebras (81.8 %) had major posterior wall deficiency (> 30 %). Clinical and radiological (CT) measures were obtained before and 3 months after the procedure. The mean VAS improved significantly from preoperative to postoperative (6.9 ± 2.2 to 3.7 ± 2.3; p < 0.05), as did the ODI (59.7 %± 19.2 % to 40.3 %± 24.0 %; p < 0.05). The physical component summary of the SF-36 was significantly improved by the operation (19.2 ± 8.0 to 31.0 ± 16.5; p < 0.05). Symptomatic cement leakage or other operation-associated complications were not observed. Three patients were primarily treated with concomitant minimally invasive stabilization via fixateur interne. One patient had to undergo minimally invasive stabilization via fixateur interne 4 months after vesselplasty due to further collapse of the treated vertebral body. From these preliminary results, vesselplasty appears to be a treatment option worth considering in pathological vertebral fractures, even in the case of posterior wall deficiency. Selected tumor patients might benefit from vesselplasty as a minimally invasive procedure for stabilization of the fractured vertebra, pain control, and improvement in body function and quality of life. Long-term prospective studies with a larger sample size are required to validate these results. © Georg Thieme Verlag KG Stuttgart · New York.

  9. Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients.

    PubMed

    Grubb, M R; Carpenter, J; Crowe, J A; Teoh, J; Marlow, N; Ward, C; Mann, C; Sharkey, D; Hayes-Gill, B R

    2014-05-01

    Around 5%-10% of newborn babies require some form of resuscitation at birth and heart rate (HR) is the best guide of efficacy. We report the development and first trial of a device that continuously monitors neonatal HR, with a view to deployment in the delivery room to guide newborn resuscitation. The device uses forehead reflectance photoplethysmography (PPG) with modulated light and lock-in detection. Forehead fixation has numerous advantages including ease of sensor placement, whilst perfusion at the forehead is better maintained in comparison to the extremities. Green light (525 nm) was used, in preference to the more usual red or infrared wavelengths, to optimize the amplitude of the pulsatile signal. Experimental results are presented showing simultaneous PPG and electrocardiogram (ECG) HRs from babies (n = 77), gestational age 26-42 weeks, on a neonatal intensive care unit. In babies ⩾32 weeks gestation, the median reliability was 97.7% at ±10 bpm and the limits of agreement (LOA) between PPG and ECG were +8.39 bpm and -8.39 bpm. In babies <32 weeks gestation, the median reliability was 94.8% at ±10 bpm and the LOA were +11.53 bpm and -12.01 bpm. Clinical evaluation during newborn deliveries is now underway.

  10. Can homeopathy bring additional benefits to thalassemic patients on hydroxyurea therapy? Encouraging results of a preliminary study.

    PubMed

    Banerjee, Antara; Chakrabarty, Sudipa Basu; Karmakar, Susanta Roy; Chakrabarty, Amit; Biswas, Surjyo Jyoti; Haque, Saiful; Das, Debarsi; Paul, Saili; Mandal, Biswapati; Naoual, Boujedaini; Belon, Philippe; Khuda-Bukhsh, Anisur Rahman

    2010-03-01

    Several homeopathic remedies, namely, Pulsatilla Nigricans (30th potency), Ceanothus Americanus (both mother tincture and 6th potency) and Ferrum Metallicum (30th potency) selected as per similia principles were administered to 38 thalassemic patients receiving Hydroxyurea (HU) therapy for a varying period of time. Levels of serum ferritin (SF), fetal hemoglobin (HbF), hemoglobin (Hb), platelet count (PC), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH), white blood cell (WBC) count, bilirubin content, alanine amino transferase (ALT), aspartate amino transferase (AST) and serum total protein content of patients were determined before and 3 months after administration of the homeopathic remedies in combination with HU to evaluate additional benefits, if any, derived by the homeopathic remedies, by comparing the data with those of 38 subjects receiving only HU therapy. Preliminary results indicated that there was a significant decrease in the SF and increase in HbF levels in the combined, treated subjects. Although the changes in other parameters were not so significant, there was a significant decrease in size of spleen in most patients with spleenomegaly and improvement in general health conditions along with an increased gap between transfusions in most patients receiving the combined homeopathic treatment. The homeopathic remedies being inexpensive and without any known side-effects seem to have great potentials in bringing additional benefits to thalassemic patients; particularly in the developing world where blood transfusions suffer from inadequate screening and fall short of the stringent safety standards followed in the developed countries. Further independent studies are encouraged.

  11. Transarterial occlusion of patent ductus arteriosus with Gianturco coils in pediatric patients: a preliminary result in central Taiwan.

    PubMed

    Lee, M L; Chaou, W T; Wang, J K

    1999-04-30

    We wish to present the preliminary result of transarterial occlusion of patent ductus arteriosus (PDA) with Gianturco coils in pediatric patients in central Taiwan. We attempted occlusion of PDA with Gianturco coils in a total of 26 consecutive patients, 13 infants and 13 children, 23 female and three male, between July 1 1997 to September 30 1998. Median patient age was 2.57 years (from 0.25 to 14.02 years old). Median patient weight was 10.8 kg (4.0 to 36.0 kg). Premature babies with PDA, full-term babies who were less than three months old and patients who had other congenital heart disease were not included in this study. All PDAs were approached transarterially from the femoral artery. Coils were selected to provide a helical diameter that was twice or more the minimum ductus diameter and a length approximating five loops. In five patients who had a PDA diameter > or =3.5 mm, we used a snare technique to assist coil delivery beforehand, and to test coil stability, or to retrieve coil that had migrated to the pulmonary artery afterwards. Physical auscultation, chest radiographs and echocardiography with color Doppler were done in all patients within 24 h, and one, two, three, six and 12 months after coil occlusion. The median ductus minimum diameter was 2.3 mm (range, 1.0 to 4.7 mm). Fifteen patients had the megaphone type (type A), four had the window type (type B), five had the tubular type (type C), one had the aneurysmal type (type D) and one had the elongated conical type (type E). Twenty-one patients underwent single coil occlusion and five had multiple coils occlusion. Twenty-one patients had immediate angiographic closure of the ductus and disappearance of heart murmur at 15 min after the procedure. Dark-brown urine (hemoglobinuria) was found in one patient, 10 h after the first procedure, due to a mild residual ductal shunt. Two more coils were implanted in a second procedure that was performed within 24 h, and the ductus was completely occluded. The

  12. Health-Related Quality of Life in Brain Tumor Patients Treated with Surgery: Preliminary Result of a Single Institution

    PubMed Central

    Kim, Chang-Wook; Joo, Jin-Deok; Kim, Young-Hoon; Han, Jung Ho

    2016-01-01

    Background Alongside the extent of removal and patients’ survival in the management of brain tumors, health-related quality of life (HRQOL) has become an important consideration. The purpose of this study is to evaluate the change of HRQOL in brain tumor patients before and after surgery and to assess the associated factors that contribute to the change of HRQOL. Methods A total of 258 patients who underwent surgical treatment were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and the 20-item EORTC QLQ-Brain Neoplasm (QLQ-BN20) were used to assess HRQOL. Patients were asked to fill out the questionnaires before and 3-6 months after surgery. Results Global QOL (p<0.001) and emotional function (p<0.018) were significantly improved after surgery. Physical function (p=0.015) was significantly aggravated. Among the symptoms, headache, pain and nausea and vomiting were significantly decreased (p<0.01, p=0.041, p<0.001, respectively), while dyspnea, communication deficit and weakness of the legs were increased (p=0.005, p=0.040, and p=0.014, respectively). Preoperative neurologic deficit (p=0.019) and tumor diameter (p=0.016) were significantly related to the patients who showed aggravation of global QOL after brain tumor surgery. In the aggravated global QOL group, common complaints and concerns included role function, appetite loss, financial difficulty and future uncertainty. Conclusion In brain tumor patients, HRQOL has improved after surgery. Role function, appetite loss, financial difficulty and future uncertainty were important factors for HRQOL in brain tumor patients treated with surgery. Although there is National Health Insurance and Medical Aid program in Korea, financial difficulty and future uncertainty are much more important in influencing QOL than previously thought. The results of this short-term follow up preliminary study suggest that several factors were

  13. Surveyor 3 Preliminary Science Results

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Surveyor III soft-landed on the Moon at 00:04 GMT on April 20, 1967. Data obtained have significantly increased our knowledge of the Moon. The Surveyor III spacecraft was similar to Surveyor I; the only major change in scientific instrumentation was the addition of a soil mechanics surface sampler. Surveyor III results at this preliminary evaluation of data give valuable information about the relation between the surface skin of under-dense material responsible for the photometric properties and the deeper layers of material whose properties resemble those of ordinary terrestrial soils. In addition, they provide new insight into the relation between the general lunar surface as seen by Surveyor I and the interior of a large subdued crater. The new results have also contributed to our understanding of the mechanism of downhill transport. Many critical questions cannot, however, be answered until final reduction of experimental data.

  14. [Should sinus rhythm be restored in patients with chronic atrial fibrillation? Preliminary results from the Polish "Hot Cafe" study].

    PubMed

    Opolski, G; Torbicki, A; Kosior, D; Stolarz, P; Dawidowska, R; Zawadzka, M; Szulc, M; Kołodziej, P; Stopiński, M; Janion, M; Achremczyk, P; Lewandowski, Z

    1999-05-01

    Atrial fibrillation (AF) is the most common arrhythmia occurring in clinical practice. It is the most frequent cause of hospitalization in cardiac rhythm disturbance. Despite comprehensive progress in the research into electrophysiological mechanisms leading to this loss of normal rhythm and new procedures dealing with it, the main problem being the conversion to and maintaining the normal sinus rhythm (SR) has not been solved. The polish study "Hot Cafe" is trying to evaluate the advantages and risks of the two procedures widely used in clinical practice in patients (pts) with chronic AF, i.e. conversion and maintaining SR vs leaving pts with the arrhythmia. Pts with non-valvular chronic AF fulfilling the criteria for including them into the sample are randomly assigned to two procedures: conversion to SR by means of direct current cardioversion and maintaining it or leaving pts with AF. Pts left with AF are treated by rate control and antithrombotic treatment. The project is of prospective kind and it will be carried out by many medical institutions. It is planned to include 200 pts. The observation period will last at least 12 months. Preliminary results after inclusion of the first 121 pts are shown.

  15. Monsoon '90 - Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Dubois, Pascale C.; Van Zyl, Jakob J.; Guerra, Abel G.

    1992-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  16. Monsoon 1990: Preliminary SAR results

    NASA Technical Reports Server (NTRS)

    Vanzyl, Jakob J.; Dubois, Pascale; Guerra, Abel

    1991-01-01

    Multifrequency polarimetric synthetic aperture radar (SAR) images of the Walnut Gulch watershed near Tombstone, Arizona were acquired on 28 Mar. 1990 and on 1 Aug. 1990. Trihedral corner reflectors were deployed prior to both overflights to allow calibration of the two SAR data sets. During both overflights, gravimetric soil moisture and dielectric constant measurements were made. Detailed vegetation height, density, and water content measurements were made as part of the Monsoon 1990 Experiment. Preliminary results based on analysis of the multitemporal polarimetric SAR data are presented. Only the C-band data (5.7-cm wavelength) radar images show significant difference between Mar. and Aug., with the strongest difference observed in the HV images. Based on the radar data analysis and the in situ measurements, we conclude that these differences are mainly due to changes in the vegetation and not due to the soil moisture changes.

  17. Preliminary results of UCN τ

    NASA Astrophysics Data System (ADS)

    Pattie, Robert; UCNtau Collaboration

    2017-01-01

    There is currently a 4 σ discrepancy between measurements of the neutron lifetime performed using cold neutron beams and those performed with ultracold neutron (UCN) storage vessels. The UCN τ experiment uses an asymmetric magneto-gravitational UCN trap with in situ counting of surviving neutrons to measure the neutron lifetime. This design eliminates a major systematic of previous bottle experiments related to the loss of UCN on material trap walls and with unloading neutrons from the storage vessel. A new in situ detection system was used in the 2015-2016 run that was able to measure the population of surviving UCN at different heights in the trap, providing important information on spectral evolution. Understanding the behavior of quasi-bound UCN in a bottle experiment is essential to achieving a subsecond precision measurement of τn. We will present the preliminary results from the 2015-2016 data set and an update on the UCN τ experiment.

  18. [Accelerated partial breast irradiation using interstitial high dose rate brachytherapy: preliminary clinical and dosimetric results after 61 patients].

    PubMed

    Hannoun-Levi, J-M; Ferré, M; Raoust, I; Lallement, M; Flipo, B; Ettore, F; Marcié, S

    2008-11-01

    Among all the accelerated and partial breast irradiation (APBI) techniques, low then high dose rate, interstitial brachytherapy (HDIB) was the first to be used in this field. This study presents the preliminary clinical and dosimetric results of the APBI using HDIB, performed in Antoine Lacassagne Cancer Center of Nice. From June 2004 to March 2008, 61 patients (37 primary tumors and 24 second conservative treatments after local recurrence) presenting with T1-2 pN0 non-lobular invasive breast carcinoma, underwent lumpectomy with sentinel lymph node dissection and intraoperative tube placement for HDIB. Dose distribution analysis, using dose-volume histograms, was achieved based on a postoperative CT scan. A comparative dosimetric study was performed between optimized (O) and non-optimized (NO) dose distribution. Then, based on conformal index calculation, a novel index was proposed taking into account not only the conformity but also the homogeneity of HDIB implant. An analysis of dose gradient impact on HDIB biological equivalence dose was also conducted. Statistical analysis used T test confirmed by Wilcoxon test for cohort including less than 30 patients. The comparative dosimetric analysis between O and NO dose distributions shown that conformity indexes (conformal index, conformal number, and D90%) were significantly increased after optimization. Improving conformity leads to increasing hyperdosage volumes (V150% and V200%). A new index named conformity and homogeneity index (CHI) including V150% values, modified the conformal index. A total dose of 34 Gy, delivered through HDIB in 10 fractions over five days was biologically equivalent to 41.93 Gy assuming alpha/beta = 4 Gy and 75.76 Gy if the dose gradient was considered in the calculation. HDIB is considered as one of the best IPAS technique. HDIB allows dose distribution optimization, skin spearing and accurate clinical target volume definition. Furthermore, HDIB dose gradient could play a key role for

  19. EUPORIAS: plans and preliminary results

    NASA Astrophysics Data System (ADS)

    Buontempo, C.

    2013-12-01

    Recent advances in our understanding and ability to forecast climate variability have meant that skilful predictions are beginning to be routinely made on seasonal to decadal (s2d) timescales. Such forecasts have the potential to be of great value to a wide range of decision-making, where outcomes are strongly influenced by variations in the climate. In 2012 the European Commission funded EUPORIAS, a four year long project to develop prototype end-to-end climate impact prediction services operating on a seasonal to decadal timescale, and assess their value in informing decision-making. EUPORIAS commenced on 1 November 2012, coordinated by the UK Met Office leading a consortium of 24 organisations representing world-class European climate research and climate service centres, expertise in impacts assessments and seasonal predictions, two United Nations agencies, specialists in new media, and commercial companies in climate-vulnerable sectors such as energy, water and tourism. The poster describes the setup of the project, its main outcome and some of the very preliminary results.

  20. Preliminary results of ANAIS-25

    NASA Astrophysics Data System (ADS)

    Amaré, J.; Cebrián, S.; Cuesta, C.; García, E.; Ginestra, C.; Martínez, M.; Oliván, M. A.; Ortigoza, Y.; Ortiz de Solórzano, A.; Pobes, C.; Puimedón, J.; Sarsa, M. L.; Villar, J. A.; Villar, P.

    2014-04-01

    The ANAIS (Annual Modulation with NaI(Tl) Scintillators) experiment aims at the confirmation of the DAMA/LIBRA signal using the same target and technique at the Canfranc Underground Laboratory. 250 kg of ultrapure NaI(Tl) crystals will be used as a target, divided into 20 modules, each coupled to two photomultipliers. Two NaI(Tl) crystals of 12.5 kg each, grown by Alpha Spectra from a powder having a potassium level under the limit of our analytical techniques, form the ANAIS-25 set-up. The background contributions are being carefully studied and preliminary results are presented: their natural potassium content in the bulk has been quantified, as well as the uranium and thorium radioactive chains presence in the bulk through the discrimination of the corresponding alpha events by PSA, and due to the fast commissioning, the contribution from cosmogenic activated isotopes is clearly identified and their decay observed along the first months of data taking. Following the procedures established with ANAIS-0 and previous prototypes, bulk NaI(Tl) scintillation events selection and light collection efficiency have been also studied in ANAIS-25.

  1. Endoscopic retroauricular thyroidectomy: preliminary results.

    PubMed

    Byeon, Hyung Kwon; Holsinger, F Christopher; Tufano, Ralph P; Park, Jae Hong; Sim, Nam Suk; Kim, Won Shik; Choi, Eun Chang; Koh, Yoon Woo

    2016-01-01

    We sought to seek the potential role of endoscopic thyroidectomy with the retroauricular (RA) approach prior to future comparative study with the robotic RA thyroidectomy. Therefore, this study aims to verify the surgical feasibility of endoscopic RA thyroidectomy. Eighteen patients who underwent endoscopic RA thyroidectomy for clinically suspicious papillary thyroid carcinoma or benign lesions from January to December 2013 were retrospectively reviewed and analyzed. All endoscopic operations via RA or modified facelift approach were successfully performed, without any significant intraoperative complications or conversion to open surgery. Based on patient-reported outcome questionnaires, all patients were satisfied with their postoperative surgical scars. Endoscopic RA thyroidectomy is technically feasible and safe with satisfactory cosmetic results for patients where indicated.

  2. Comparative Soot Diagnostics: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Urban, David L.; Griffin, DeVon W.; Gard, Melissa Y.

    1997-01-01

    detected and suppressed. Prior to CSD, no combustion-generated particulate samples had been collected near the flame zone for well-developed microgravity flames. All of the extant data either came from drop tower tests and therefore only corresponded to the early stages of a fire or were collected far from the flame zone. The fuel sources in the drop tower tests were restricted to laminar gas-jet diffusion flames and very rapidly overheated wire insulation. The gas-jet tests indicated, through thermophoretic sampling, (2) that soot primaries and aggregates (groups of primary particles) in low-gravity may be significantly larger than those in normal gravity (1-g). This raises new scientific questions about soot processes as well as practical issues for particulate size sensitivity and detection alarm threshold levels used in on-orbit smoke detectors. Preliminary tests in the 2.2 second drop tower suggest that particulate generated by overheated wire insulation may be larger in low-g than in 1-g. Transmission Electron Microscope (TEM) grids downstream of the fire region in the Wire Insulation Flammability experiment as well as visual observation of long string-like aggregates, further confirm this suggestion. The combined impact of these limited results and theoretical predictions is that, as opposed to extrapolation from l-g data, direct knowledge of low-g combustion particulate is needed for more confident design of smoke detectors for spacecraft. This paper describes the operation and preliminary results of the CSD, a project conceived and developed at NASA Lewis Research Center. The CSD flight experiment was conducted in the Middeck Glovebox Facility (MGBX) on USMP-3. The project is support by NASA Headquarters Microgravity Science and Applications Division and Code Q. The results presented here are from the microgravity portion of the experiment, including the temporal response of the detectors and average sizes of the primary and aggregate particles captured on the

  3. Accuracy of Intravascular Ultrasound Evaluation for the Assessment of Native Valve Measures in Patients Undergoing TAVI: Preliminary Results.

    PubMed

    de Cillis, Emanuela; Dachille, Annamaria; Giardinelli, Francesco; Acquaviva, Tommaso; Bortone, Alessandro Santo

    2016-10-26

    score mortality 20.9±14.9%). Each patient scheduled for TAVI underwent coronary angiography and high resolution angio-CT in order to obtain a complete evaluation (diameters, perimeters, and areas at annulus level, -3mm level, +15mm level, height of coronary ostia, shape, and conformation of left ventricle outflow tract, conformation, and calcifications of aortic and ileo-femoral axis) to choose the most suitable prosthetic aortic valve for each patient. In all patients, during the procedure (before the prosthetic valve implantation), we executed a manual IVUS pullback (from left ventricle outflow tract to ascending aorta) by using a 7F IVUS probe (Volcano Corporation, San Diego, CA). On the recorded IVUS pullback, a second operator (who did not know the values obtained by CT measurements) identified the aortic annulus and, at this level, measured: minimum and maximum diameter; perimeter; derived perimeter, and area. The t-student test has been used to compare the averages of these IVUS values to the CT ones. A p value< 0.05 was considered as statistically significant. Independently from the kind and size of implanted prosthetic valve, no statistical differences were found when the averages of all considered parameters (obtained both with CT and IVUS) were compared. The following are the results obtained: minimum diameter (CT: 19,62mm±1,10 vs. IVUS: 19,55mm±1,40; p=0.41); maximum diameter (CT: 24,73mm±2,42 vs. IVUS: 25,9mm±1,80; p=0.08); perimeter (CT: 72,05mm±4,36 vs. IVUS: 73,32mm±6,09; p=0.164); derived perimeter (CT: 22,94mm±1,40 vs. IVUS: 23,32mm ± 1,95; p=0,198); and area (CT: 3,99cm2 ±0,97 vs. IVUS: 4,06 cm2 ± 0,47; p=0,073) (Figs. 1-3). These preliminary data suggest accurate IVUS measures when compared to CT in the evaluation of valve parameters considered (minimum and maximum diameters, area, perimeter, and derived perimeter at the annulus level). In order to confirm these findings and to give them statistical significance, it will be necessary to

  4. Usefulness of Urinoculture to Patients With Dementia and Femoral Neck Fracture at Admission to Hospital: Preliminary Results.

    PubMed

    Garcia-Nuño, Laura; Villamil, Carlos; González-Cuevas, Araceli; Martí, David; Capilla, Silvia; Vives, Maria José; Oncins, Xavier; Torner, Pere; Castellanos, Juan; Font-Vizcarra, Lluís

    2017-03-01

    While preoperative urinary tract infection (UTI) has the potential to cause bacteremia and postsurgical acute prosthetic joint infections (APJIs), the influence of asymptomatic bacteriuria (AB) in these infections remains unclear. So the majority of guidelines not recommend the treatment of AB prior to the surgery. However, as patients with dementia usually cannot explain the symptoms of dysuria, the differential diagnosis between AB and UTI may be very difficult in this group of patients. The principal aim of the study was to compare the rate of positive urine culture at admission in patients with femoral neck fracture with and without dementia and secondarily try to assess the connection of positive urinoculture and postoperative acute gram-negative PJI. All patients with a femoral neck fracture underwent a urine culture on hospital admission and were prospectively recorded. Variables such as sex, age, institutionalization, dementia and other comorbidities, PJI rate, and in-hospital death were collected. The results of cultures were retrospectively revised. Patients who received postoperative antibiotics or had been diagnosed with UTI during hospital stay were excluded. Statistical comparisons between patients with and without dementia were performed using SPSS software version 17. A total of 148 patients were included (52 with dementia). The rate of positive urine culture was 32% (n = 16) in patients with dementia and 11.5% in patients without dementia (P = .003). Of these 16 patients with dementia and positive urine culture, 2 (12.5%) developed an acute gram-negative PJI, whereas there were no cases in the group without dementia (P = .011). The only difference between UTI and AB is the expression of symptoms by the patient. However, as patients with dementia have difficulties to explain UTI symptoms, some UTI may be underdiagnosed. Patients with dementia have a statistically higher rate of presurgical positive urine culture compared with patients without

  5. Care Management Medical Home Center Model: Preliminary Results of a Patient-Centered Approach to Improving Care Quality for Diabetic Patients.

    PubMed

    Page, Timothy F; Amofah, St Anthony; McCann, Shelia; Rivo, Julie; Varghese, Asha; James, Terisa; Rivo, Marc; Williams, Mark L

    2015-07-01

    This article presents preliminary findings of the impact of an innovative care management model for diabetic patients. The model was implemented by seven Federally Qualified Health Centers serving 10,000 diabetic patients in Miami-Dade County. A primary intervention of this model is a centralized care management team that makes previsit phone calls to diabetic patients who have scheduled appointments. These previsit phone calls optimize patient knowledge and self-management goals, and provide patient care coordinators with relevant clinical information to optimize the office visit and help to ensure completion of recommended diabetic preventive and chronic care services. Data suggest that following the implementation of this care management model, more diabetic patients are receiving regular care, and compliance with recommended tests and screenings has improved.

  6. Postoperative survival for patients with thymoma complicating myasthenia gravis—preliminary retrospective results of the ChART database

    PubMed Central

    Wang, Fangrui; Fu, Jianhua; Shen, Yi; Wei, Yucheng; Tan, Lijie; Zhang, Peng; Han, Yongtao; Chen, Chun; Zhang, Renquan; Li, Yin; Chen, Keneng; Chen, Hezhong; Liu, Yongyu; Cui, Youbing; Wang, Yun; Yu, Zhentao; Zhou, Xinming; Liu, Yangchun; Liu, Yuan; Gu, Zhitao

    2016-01-01

    Background It is so far not clear that how myasthenia gravis (MG) affected the prognosis of thymoma patients. The aim of this assay is to compare the postoperative survival between patients with thymoma only and those with both thymoma and MG. Methods The Chinese Alliance for Research in Thymomas (ChART) registry recruited patients with thymoma from 18 centers over the country on an intention to treat basis from 1992 to 2012. Two groups were formed according to whether the patient complicated MG. Demographic and clinical data were reviewed, patients were followed and their survival status were analyzed. Results There were 1,850 patients included in this study, including 421 with and 1,429 without MG. Complete thymectomy were done in 91.2% patients in MG group and 71.0% in non-MG group (P<0.05). There were more percentage of patients with the histology of thymoma AB, B1, or B2 (P<0.05) in MG group, and more percentage of patients with MG were in Masaoka stage I and II. The 5- and 10-year overall survival (OS) rates were both higher in MG group (93% vs. 88%; 83% vs. 81%, P=0.034) respectively. The survival rate was significantly higher in patients with MG when the Masaoka staging was 3/4 (P=0.003). Among patients with advanced stage thymoma (stage 3, 4a, 4b), the constituent ratios of 3, 4a, 4b were similar between MG and non-MG group. Histologically, however, there were significantly more proportion of AB/B1/B2/B3 in the MG group while there were more C in the non-MG group (P=0.000). Univariate analyses for all patients showed that MG, WHO classification, Masaoka stage, surgical approach, chemotherapy and radiotherapy and resectability were significant factors, and multivariate analysis showed WHO classification, Masaoka stage, and resectability were strong independent prognostic indicators. Conclusions Although MG is not an independent prognostic factor, the survival of patients with thymoma was superior when MG was present, especially in late Masaoka stage

  7. [Study of circadian rhythms of activity by actometry: preliminary results in 30 patients with metastatic colorectal cancer].

    PubMed

    Mormont, M C; De Prins, J; Lévi, F

    1996-03-01

    Activity circadian rhythms were measured non-invasively in 30 patients with metastatic colorectal cancer by wrist actigraphy, and compared with control data. Patients and control subjects were requested to wear the actigraph at home for 2 to 5 days. Control time-series exhibit high activity levels (150 to 350 counts/min) during daytime, followed by low activity levels (0 to 50 counts/min) during the night. In patients, the contrast between daytime activity and nocturnal sleep is noticeably less marked, and a wide inter-patient variability can be observed. This alteration of the rest-activity rhythm in the cancer group was statistically validated by autocorrelation test. Results from the cosinor and he maximal entropy spectral analysis must be interpreted more cautiously, since the prerequisites for these tests may not be fulfilled by actometric time-series. These results indicate that cancer patients may have altered rest-activity circadian rhythms. The significance and prognostic value of such alterations deserve further testing in a larger population. Actigraphy may provide a simple and innovative tool to study the circadian system in cancer patients.

  8. Successful hepatitis B vaccination in patients who underwent transplantation for hepatitis B virus-related cirrhosis: preliminary results.

    PubMed

    Bienzle, Ulrich; Günther, Matthias; Neuhaus, Ruth; Neuhaus, Peter

    2002-06-01

    Long-term hepatitis B immunoglobulin (HBIg) prophylaxis prevents endogenous hepatitis B virus (HBV) reinfection in the majority of liver transplant recipients. Active hepatitis B vaccination after orthotopic liver transplantation (OLT) in these patients has produced conflicting results to date. On this study, patients who remained hepatitis B surface antigen (HBsAg) negative with passive immunization after OLT for HBV cirrhosis were actively immunized using recombinant HBV antigen (Engerix), together with a novel adjuvant system (monophosphoryl lipid A and a natural saponine molecule). This led to a sustained antibody response to HBsAg (>500 IU/L) in 5 of 10 patients. This antibody response prevented reinfection and allowed termination of prophylactic HBIg substitution for more than 12 months in these patients.

  9. Infliximab, an anti-TNF-alpha agent, improves left atrial abnormalities in patients with rheumatoid arthritis: preliminary results

    PubMed Central

    Süha, Çetin; Mustafa Gökhan, Vural; Ekrem, Yeter; Mehmet, Doğan; Göksal, Keskin; Mehmet Akif, Öztürk

    2014-01-01

    Summary Background Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality. In the current prospective study, we addressed the impact of RA on left atrial (LA) function and electrical remodelling. Further, we tried to demonstrate the effects of infliximab, an anti-TNFalpha agent, on echocardiographical LA abnormality in RA patients with preserved left ventricular (LV) ejection fraction. Methods We compared 38 female RA patients without clinical evidence of heart disease and 30 female controls without RA and clinical evidence of heart disease. Further, we compared RA patients receiving infliximab and increasing doses of prednisolone over a three-month period. At baseline and post treatment, this study assessed (1) LA and LV parameters using conventional and speckle tracking echocardiography (STE), and (2) electrocardiographic P-wave changes. Results The values of C-reactive protein (CRP), isovolumic relaxation time (IVRT), A wave, and deceleration time (DT) were significantly higher in RA patients compared to the control group (p < 0.05), whereas E/E′ and E/A values were found to be lower (p < 0.05) in RA patients. E/E′ values were lower in prednisolone- compared to infliximab-treated patients (p < 0.05). After three months of infliximab and prednisolone treatment, CRP and disease activity score (DAS 28) values decreased in both groups (p < 0.05), and Duke activity status index (DASI) increased (p < 0.05). Maximal left atrial volume index (LAVImax), pre-contraction left atrial volume index (LAVIpreA) and maximum P wave (Pmax) of the RA patients were higher compared to the control group (p < 0.05), whereas LA global strain was found to be lower (p < 0.05). There was no difference in Pmax values between groups before and after the treatment period. E/E′, LAVImax and LAVIpreA values of infliximab-treated patients decreased and LA global strain increased after three months of therapy compared to baseline (p < 0.05). At

  10. Preliminary Results of Helical Tomotherapy in Patients with Complex-Shaped Meningiomas Close to the Optic Pathway

    SciTech Connect

    Schiappacasse, Luis Cendales, Ricardo; Sallabanda, Kita; Schnitman, Franco; Samblas, Jose

    2011-01-01

    Meningiomas are the most common benign intracranial tumor. Meningiomas close to the optic pathway represent a treatment challenge both for surgery and radiotherapy. The aim of this article is to describe early results of helical tomotherapy treatment in complex-shaped meningiomas close to the optic pathway. Twenty-eight patients were consecutively treated. All patients were immobilized with a thermoplastic head mask and planned with the aid of a magnetic resonance imaging-computed tomography fusion. All treatments included daily image guidance. Pretreatment symptoms and acute toxicity were recorded. Median age was 57.5 years, and 92.8% patients had Eastern Cooperative Oncology Group performance status scale {<=}1. The most common localizations were the sella turcica, followed by the cavernous sinus and the sphenoid. The most common symptoms were derived from cranial nerve deficits. Tomotherapy was administered as primary treatment in 35.7% of patients, as an adjuvant treatment in 32.4%, and as a rescue treatment after postsurgical progression in 32.1% patients. Most patients were either inoperable or Simpson IV. Total dose varied between 5000 and 5400 cGy; fractionation varied between 180 and 200 cGy. Median dose to the planning target volume was 51.7 Gy (range, 50.2-55.9 Gy). Median coverage index was 0.89 (range, 0.18-0.97). Median homogeneity index was 1.05 (range, 1-1.12). Acute transient toxicity was grade 1 and included headache in 35.7% patients, ocular pain/dryness in 28.5%, and radiation dermatitis in 25%. Thus far, with a maximal follow-up of 3 years, no late effects have been seen and all patients have a radiological stabilization of the disease. Helical tomotherapy offered a safe and effective therapeutic alternative for patients with inoperable or subtotally resected complex-shaped meningiomas close to the optic pathway. Acceptable coverage and homogeneity indexes were achieved with appropriate values for maximal doses delivered to the eyes, lenses

  11. Interactive videogame as rehabilitation tool of patients with chronic respiratory diseases: preliminary results of a feasibility study.

    PubMed

    Mazzoleni, Stefano; Montagnani, Giulia; Vagheggini, Guido; Buono, Lorenzo; Moretti, Francesca; Dario, Paolo; Ambrosino, Nicolino

    2014-10-01

    To evaluate the effectiveness of an interactive videogame (IV) system in addition to a supervised pulmonary rehabilitation programme (PRP) in patients with chronic respiratory diseases. Randomised Controlled Trial comparing standard PRP (20 patients, control group: CG), and PRP + sessions of interactive videogame-aided exercises (20 patients, experimental group: EG). Lung and respiratory muscle function, arterial blood gases, exercise capacity, dyspnoea, health status and health-related quality of life (HRQL) and emotional response were measured before and after PRP. A questionnaire on acceptability of the PRP was administered. Exercise capacity, dyspnoea and HRQL significantly improved in both groups after the PRP, whereas the EG showed a greater improvement in six-minute walk test and transitional dyspnoea index than the CG. No difference in psychological status or acceptability of PRP was observed between the two groups. The addition of IV training was more effective for improving some parameters of exercise tolerance and dyspnoea, although did not result in better psychological status nor it was better accepted than the standard PRP in patients with chronic respiratory diseases. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. REMS Wind Sensor Preliminary Results

    NASA Astrophysics Data System (ADS)

    De La Torre Juarez, M.; Gomez-Elvira, J.; Navarro, S.; Marin, M.; Torres, J.; Rafkin, S. C.; Newman, C. E.; Pla-García, J.

    2015-12-01

    The REMS instrument is part of the Mars Science Laboratory payload. It is a sensor suite distributed over several parts of the rover. The wind sensor, which is composed of two booms equipped with a set of hot plate anemometers, is installed on the Rover Sensing Mast (RSM). During landing most of the hot plates of one boom were damaged, most likely by the pebbles lifted by the Sky Crane thruster. The loss of one wind boom necessitated a full review of the data processing strategy. Different algorithms have been tested on the readings of the first Mars year, and these results are now archived in the Planetary Data System (PDS), The presentation will include a description of the data processing methods and of the resulting products, including the typical evolution of wind speed and direction session-by-session, hour-by-hour and other kinds of statistics . A review of the wind readings over the first Mars year will also be presented.

  13. A History of Childhood Trauma and Response to Treatment With Antipsychotics in First-Episode Schizophrenia Patients: Preliminary Results.

    PubMed

    Misiak, Błażej; Frydecka, Dorota

    2016-10-01

    In this study, we aimed to investigate whether a history of childhood trauma (CT) can help predict early response to antipsychotic treatment in patients with first-episode schizophrenia (FES). We recruited 64 FES patients who were followed up after 12 weeks of treatment with second-generation antipsychotics. Symptomatic manifestation was examined using the Positive and Negative Syndrome Scale (PANSS). Childhood adversities were assessed using the Early Trauma Inventory Self-Report-Short Form. Nonresponders had significantly higher general trauma score, emotional abuse score, total trauma score, and baseline PANSS negative factor score. A history of CT was significantly more frequent among nonresponders. Logistic regression analysis revealed that positive history of CT, higher emotional abuse score, and higher baseline PANSS negative factor score are significant predictors of poor response to treatment. Our results indicate that a history of CT, especially emotional abuse, and higher severity of negative symptoms are independent predictors of poor response to treatment with antipsychotics.

  14. Preliminary Estimation of the Prognostic Value of the Haemodynamic Results of Doppler Examination in Severely Burned Patients

    PubMed Central

    Bujok, G.

    2006-01-01

    Summary It is difficult to define all cardiac risk factors in the course of burn treatment. The adequate function of the circulatory system is the main factor in successful therapy. The aim of this study was to define, using a transoesophageal Doppler system, the cardiac circulatory risk factors of death in burn patients. One hundred and forty-seven burn patients were divided into two groups defined as survivors and non-survivors. In both groups the following haemodynamic parameters were analysed: 1. cardiac output; 2. stroke volume (SV); 3. heart rate (HR); 4. flow time (FT); 5. peak velocity; 6. average acceleration. The differential statistical significance was evidenced by analysis of SV, FT, and HR, using the ANOVA test. All the results showed that the best predictor factors for survival were SV and HR. PMID:21991026

  15. Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry

    PubMed Central

    Brola, Waldemar; Sobolewski, Piotr; Fudala, Małgorzata; Flaga, Stanisław; Jantarski, Konrad; Ryglewicz, Danuta; Potemkowski, Andrzej

    2016-01-01

    Background The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry. Methods This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL. Results The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status. Conclusion The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to

  16. Preliminary results of a phase I/II clinical trial using in situ photoimmunotherapy combined with imiquimod for metastatic melanoma patients

    NASA Astrophysics Data System (ADS)

    Li, Xiaosong; Naylor, Mark F.; Nordquist, Robert E.; Teague, T. Kent; Howard, C. Anthony; Murray, Cynthia; Chen, Wei R.

    2010-02-01

    In Situ Photoimmunotherapy (ISPI), a newly developed modality for cancer therapy, has been shown to be able to modulate the body's own immune response. This clinical trial was designed to evaluate the safety and therapeutic effect of ISPI, using imiquimod as its immunoadjuvant for metastatic melanoma patients. ISPI consisted of three main components applied directly to the cutaneous metastases: 1) local application of topical imiquimod; 2) injection of indocyanine green; and 3) an 805 nm laser for local irradiation. All patients completed at least one cycle of treatment. All the patients completed at least one cycle of treatments; one patient received 6 cycles. The most common adverse effects were rash, pruritus, pain, fatigue and anorexia. Fever, chills, vomiting and cellulitis were relative rare. No grade 4 toxicity was observed. Complete Response (CR) was observed in 6 patients. Median overall survival of the 11 evaluated patients was 12.2 months. Six of the eleven patients were still alive at the time of this report. Treatment of ISPI using imiquimod is safe and well tolerant. Our preliminary clinical results suggest that this new method can be a promising modality for metastatic melanoma.

  17. The ChQoL questionnaire: an Italian translation with preliminary psychometric results for female oncological patients

    PubMed Central

    2010-01-01

    Background in Occidental languages, no widely accepted questionnaire is available which deals with health related quality of life from the specific point of view of Traditional Chinese Medicine (TCM). Some psychometric tools of this kind are available in Chinese. One of them is the Chinese Quality of Life questionnaire (ChQoL). It comprises 50 items, subdivided in 3 Domains and 13 Facets. The ChQoL was built from scratch on the basis of TCM theory. It is therefore specifically valuable for the TCM practitioner. This paper describes our translation into Italian of the ChQoL, its first application to Occidental oncological patients, and some of its psychometric properties. Methods a translation scheme, originally inspired by the TRAPD procedure, is developed. This scheme focuses on comprehensibility and clinical usefulness more than on linguistic issues alone. The translated questionnaire is tested on a sample of 203 consecutive female patients with breast cancer. Shapiro-Wilk normality tests, Fligner-Killeen median tests, exploratory Two-step Cluster Analysis, and Tukey's test for non-additivity are applied to study the outcomes. Results an Italian translation is proposed. It retains the TCM characteristics of the original ChQoL, it is intelligible to Occidental patients who have no previous knowledge of TCM, and it is useful for daily clinical practice. The score distribution is not Normal, and there are floor and ceiling effects. A Visual Analogue Scale is identified as a suitable choice. A 3-point Likert scale can also efficiently describe the data pattern. The original scales show non-additivity, but an Anscombe-Tukey transformation with γ = 1.5 recovers additivity at the Domain level. Additivity is enhanced if different γ are adopted for different Facets, except in one case. Conclusions the translated questionnaire can be adopted both as a filing system based on TCM and as a source of outcomes for clinical trials. A Visual Analogue Scale is recommended, but a

  18. Preliminary results of an intravitreal dexamethasone implant (Ozurdex®) in patients with persistent diabetic macular edema

    PubMed Central

    Pacella, Elena; Vestri, Anna Rita; Muscella, Roberto; Carbotti, Maria Rosaria; Castellucci, Massimo; Coi, Luigi; Turchetti, Paolo; Pacella, Fernanda

    2013-01-01

    Background To evaluate the efficacy and safety of an intravitreal dexamethasone implant (Ozurdex®; Allergan Inc, Irvine, CA, USA) in patients with persistent diabetic macular edema (DME) over a 6-month follow-up period. Methods Seventeen patients (20 eyes) affected by DME were selected. The mean age was 67 + 8 years, and the mean duration of DME was 46.3 + 18.6 months. The eligibility criteria were: age ≥ 18, a best-corrected visual acuity between 5 and 40 letters, and macular edema with a thickness of ≥275 μm. Thirteen patients had also previously been treated with anti-vascular endothelial growth factor medication. Results The mean ETDRS (Early Treatment Diabetic Retinopathy Study) value went from 18.80 + 11.06 (T0) to 26.15 + 11.03 (P = 0.04), 28.15 + 10.29 (P = 0.0087), 25.95 + 10.74 (P = 0.045), 21.25 + 11.46 (P = 0.5) in month 1, 3, 4, and 6, respectively. The mean logMAR (logarithm of the minimum angle of resolution) value went from 0.67 + 0.23 (at T0) to 0.525 + 0.190 (P = 0.03), 0.53 + 0.20 (P = 0.034), and 0.56 + 0.22 (P = 0.12) in month 1, 3, and 4, respectively, to finally reach 0.67 + 0.23 in month 6. The mean central macular thickness value improved from 518.80 + 224.75 μm (at T0) to 412.75 + 176.23 μm, 292.0 + 140.8 μm (P < 0.0001), and 346.95 + 135.70 (P = 0.0018) on day 3 and in month 1 and 3, respectively, to then increase to 476.55 + 163.14 μm (P = 0.45) and 494.25 + 182.70 μm (P = 0.67) in month 4 and 6. Conclusion The slow-release intravitreal dexamethasone implant, Ozurdex, produced significant improvements in best-corrected visual acuity and central macular thickness from the third day of implant in DME sufferers, and this improvement was sustained until the third month. PMID:23901252

  19. Impact of Intrascalar Electrode Location, Electrode Type, and Angular Insertion Depth on Residual Hearing in Cochlear Implant Patients: Preliminary Results.

    PubMed

    Wanna, George B; Noble, Jack H; Gifford, Rene H; Dietrich, Mary S; Sweeney, Alex D; Zhang, Dongqing; Dawant, Benoit M; Rivas, Alejandro; Labadie, Robert F

    2015-09-01

    To evaluate the relationship between intrascalar electrode location, electrode type (lateral wall, perimodiolar, and midscala), and angular insertion depth on residual hearing in cochlear implant (CI) recipients. Tertiary academic hospital. Adult CI patients with functional preoperative residual hearing with preoperative and postoperative CT scans. Audiological assessment after CI. Electrode location, angular insertion depth, residual hearing post-CI, and word scores with CI (consonant-nucleus-consonant [CNC]). Forty-five implants in 36 patients (9 bilateral) were studied. Thirty-eight electrode arrays (84.4%) were fully inserted in scala tympani (ST), 6 (13.3%) crossed from ST to scala vestibuli (SV), and 1 (2.2%) was completely in SV. Twenty-two of the 38 (57.9%) with full ST insertion maintained residual hearing at 1 month compared with 0 of the 7 (0%) with non-full ST insertion (p = 0.005). Three surgical approaches were used: cochleostomy (C) 6/44, extended round window (ERW) 8/44, and round window (RW) 30/44. C and ERW were small group to compare with RW approaches. However if we combine C + ERW, then RW has higher chance of full ST insertion (p = 0.014). Looking at the full ST group, neither age, sex, nor electrode type demonstrated statistically significant associations with hearing preservation (p = 0.646, p = 0.4, and p = 0.929, respectively). The median angular insertion depth was 429° (range, 373°-512°) with no significant difference between the hearing and nonhearing preserved groups (p = 0.287). Scalar excursion is a strong predictor of losing residual hearing. However, neither age, sex, electrode type, nor angular insertion depth was correlated with hearing preservation in the full ST group. Techniques to decrease the risk of electrode excursion from ST are likely to result in improved residual hearing and CI performance.

  20. Prostate elastography: preliminary in vivo results

    NASA Astrophysics Data System (ADS)

    Alam, S. K.; Feleppa, E. J.; Kalisz, A.; Ramchandran, S.; Ennis, R. D.; Lizzi, Frederick L.; Wuu, C.-S.; Ketterling, Jeffrey A.

    2005-04-01

    We report preliminary results from our investigation of in vivo prostate elastography. Fewer than 50% of all prostate cancers are typically visible in current clinical imaging modalities. Elastography displays a map of strain that results when tissue is externally compressed. Thus, elastography is ideal for imaging prostate cancers because they are generally stiffer than the surrounding tissue and stiffer regions usually exhibit lower strain in elastograms. In our study, digital radio-frequency (RF) ultrasound echo data were acquired from prostate-cancer patients undergoing brachytherapy. Seed placement is guided by a transrectal ultrasound (TRUS) probe, which is held in a mechanical fixture. The probe can be moved in XYZ directions and tilted. The probe face, in contact with the rectal wall, is used to apply a compression force to the immediately adjacent prostate. We also used a water-filled (acoustic) coupling balloon to compress the prostate by increasing the water volume inside the balloon. In each scan plane (transverse), we acquired RF data from successive scans at the scanner frame rate as the deformation force on the rectal wall was continuously increased. We computed strain using 1D RF cross-correlation analysis. The compression method based on fixture displacement produced low-noise elastograms that beautifully displayed the prostate architecture and emphasized stiff areas. Balloon-based compression also produced low-noise elastograms. Initial results demonstrate that elastography may be useful in the detection and evaluation of prostate cancers, occult in conventional imaging modalities.

  1. Prospective computer-assisted voice analysis for patients with early stage glottic cancer: A preliminary report of the functional result of laryngeal irradiation

    SciTech Connect

    Harrison, L.B.; Solomon, B.; Miller, S.; Fass, D.E.; Armstrong, J.; Sessions, R.B. )

    1990-07-01

    In January 1987 we began a prospective study aimed at evaluating objective parameters of vocal function for all patients treated with RT for early glottic cancer. All patients underwent vocal analysis using a voice analyzer interfaced with a computer. This allowed for the determination of percent voicing (%V) (normal = presence of phonation = 90-100%V). Other parameters such as breathiness and strain were also measured. Patients were recorded before RT, weekly during RT, and at set intervals after RT. There have been 25 patients studied. Eighteen (18) are evaluable at 9 months after treatment. All patients were male and ranged from 45-84 years old. Fourteen (14) and T1 lesions and received 66 GY/33 fractions to their larynx and 4 had T2 tumors and received 66-70 Gy/33-35 fractions. To date, all patients are locally controlled. Three distinct patterns of %V changes have been encountered. However, all patients demonstrated normal phonation pattern by 3 months after RT, and this is sustained at 9 months follow-up. In addition, 94% of patients have had significant decrease in breathiness after RT, which objectively documents diminished hoarseness. In 83%, breathiness is normal after RT. Most patients have had increased strain after RT, which documents increased vocal cord tension. However, strain remained within normal limits in 89%. Our preliminary analysis suggests that the majority of patients irradiated for early glottic cancer demonstrate a decrease in breathiness and an increase in strain after RT, and enjoy a resultant voice that has normal phonation maintained at 9 months after RT. Our data also demonstrate three distinct phonation patterns. Further follow-up will allow us to determine the prognostic significance, if any, of these patterns, and to continue to follow objective vocal parameters on larger numbers of patient.

  2. Temozolomide in non-small-cell lung cancer: preliminary results of a phase II trial in previously treated patients.

    PubMed

    Adonizio, Christian S; Babb, James S; Maiale, Christine; Huang, Chao; Donahue, Judy; Millenson, Michael M; Hosford, Martha; Somer, Robert; Treat, Joseph; Sherman, Eric; Langer, Corey J

    2002-05-01

    Virtually all patients with advanced non-small-cell lung cancer (NSCLC) relapse. Docetaxel has an established, Food and Drug Administration-approved role as salvage therapy in previously treated, platinum-exposed patients. However, the response rate in phase III studies is < 15%, and median survival is only 6-8 months. Temozolomide, a novel triazene derivative with activity in melanoma and anaplastic astrocytoma, has demonstrated activity in C26 adenocarcinoma, Lewis lung cancer, and in phase I studies. A phase II trial was mounted using a unique schedule of oral temozolomide 75 mg/m2 daily for 6 weeks every 8-10 weeks, in patients with previously treated, advanced, incurable NSCLC. Eligibility stipulated an Eastern Cooperative Oncology Group performance status (PS) of 0-2, adequate end organ function, up to 1 prior chemotherapy for advanced (relapsed or metastatic) disease, and up to 1 prior regimen in the context of radiosensitization, adjuvant therapy, or induction. From March 2000 through January 2002, 47 patients (24 male, 23 female) were enrolled. The median age was 67 years. Sixteen patients had a PS of 2, 22 had a PS of 1, and 9 had a PS of 0. It was too early to evaluate 9 patients. Toxicity, with the exception of mild nausea and thrombocytopenia, was negligible. Three patients had a delayed recovery of platelets prompting discontinuation of treatment. Of the 38 evaluable patients, 1 patient had a complete response, 2 patients had a partial response, 12 had stable disease, and 19 had disease progression. Four patients were not evaluable. Six patients died within 30 days of taking temozolomide; 5 of these deaths were not related to treatment upon review by an independent data safety monitoring committee. Temozolomide, using a unique 6-week continuous schedule, has demonstrated activity in the salvage therapy of advanced NSCLC. Toxicity is modest, and accrual to this study continues.

  3. Improvement in Serum Anti-Müllerian Hormone Levels in Infertile Patients after Hyperbaric Oxygen (preliminary results).

    PubMed

    Pineda, Jesus Fernando Gallardo; Ortiz, Carlos Gerardo Salazar López; Moguel, Gonzalo de Jesus Siu; Lopez, Carlos Roberto Eduardo Castro; Alcocer, Héctor Mondragón; Velasco, Sergio Téllez

    2015-05-01

    To assess whether hyperbaric oxygen sessions elevate serum levels of anti-Müllerian hormone (AMH) in patients diagnosed with infertility with serum levels of less than or equal to 1 ng/dl AMH. A study was performed on 4 patients diagnosed with infertility. Serum AMH level was measured at the beginning and end of hyperbaric oxygen sessions, and endometrial thickness was measured on endometrial cycle day 14 before and during the hyperbaric oxygen sessions. In two of the four patients, the serum AMH level increased by 40% and 116%. In one patient the serum AMH level was not elevated, with a serum AMH level before and after treatment of 0.1 ng/dl. The fourth patient became pregnant during the hyperbaric oxygen sessions. Endometrial thickness was not improved in any of our patients. This study showed that hyperbaric oxygen sessions can increase serum AMH levels, with a significant increase of 116% in one case. Therefore, this therapy can be used as an alternative treatment for patients with serum AMH levels of less than or equal to 1 ng/dl and a limited number of eggs for IVF cycles but not for patients with serum AMH levels of less than or equal to 0.1 ng/dl, as we did not observe an increase in serum AMH level in patients with an initial AMH level of 0.1 ng/dl. This study did not demonstrate improvement in endometrial growth following hyperbaric oxygen sessions.

  4. Technical and practical aspects of remote monitoring of implantable cardioverter-defibrillator patients in Poland - preliminary results.

    PubMed

    Przybylski, Andrzej; Zakrzewska-Koperska, Joanna; Maciag, Aleksander; Derejko, Paweł; Orczykowski, Michał; Szumowski, Lukasz; Walczak, Franciszek

    2009-05-01

    The aim of remote monitoring of implantable cardioverter-defibrillators (ICD) is to increase the patient's safety by early detection of technical or medical malfunctions and decrease the number of follow-up visits. To evaluate the feasibility and reliability of internet-based home monitoring of ICD recipients in Poland. Twenty-seven patients with ICD with remote monitoring options were evaluated; 20 (74%) patients had a single chamber ICD, 6 (22%) patients had a dual chamber ICD and one had an ICD with a resynchronisation therapy option. Medical and technical events reported by the remote monitoring system as well as interruptions in monitoring longer than 14 days were analysed. The patients were followed for 12.7 +/- 10.5 months. Two of them died because of heart failure (6 and 13 months after ICD implantation, respectively). The remote monitoring system reported medical events in 13 (48%) patients. In total, we received 32 event reports (from 1 to 19 per patient, mean 2.6) which were generated due to the detection of ventricular tachycardia (VT) (17 events in 9 patients), ventricular fibrillation (VF) (9 episodes in 6 patients), ineffective defibrillation with the maximal energy (5 reports in 3 patients) and supraventricular tachycardia in the VT detection window (1). Two patients had more than 3 VT/VF episodes during 24 h. There were no reports on technical abnormalities of the ICD system. Interruptions in home monitoring longer than 14 days occurred in 5 (18.5%) patients and lasted 2 to 14 weeks (mean 2.8 +/- 7.1). The longest break was caused by the patient's stay abroad. The remaining interruptions were caused by: journeys (5 episodes), hospitalisations (4), and a temporary stay in a place without sufficient GSM coverage (3). During the follow-up period there were no interruptions in monitoring caused by transmitter or ICD failure. All data received by the home monitoring system were confirmed during the follow-up visits. Remote monitoring of ICD recipients

  5. Relationship Between Enterococcus faecalis Infective Endocarditis and Colorectal Neoplasm: Preliminary Results From a Cohort of 154 Patients.

    PubMed

    Pericàs, Juan M; Corredoira, Juan; Moreno, Asunción; García-País, M José; Falces, Carlos; Rabuñal, Ramón; Mestres, Carlos A; Alonso, M Pilar; Marco, Francesc; Quintana, Eduard; Almela, Manel; Paré, Juan C; Llopis, Jaume; Castells, Antoni; Miró, José M

    2017-06-01

    The association between Streptococcus bovis group infective endocarditis and colorectal neoplasm (CRN) is well-known. However, no studies have assessed the association between Enterococcus faecalis infective endocarditis (EFIE) and CRN. We aimed to determine whether the prevalence of CRN is higher in patients with EFIE and an unclear source of infection than in patients with EFIE and a known source of infection or in the general population. Retrospective analysis of a cohort of 154 patients with definite EFIE (109 with an unclear source of infection and 45 with an identified source) from 2 Spanish teaching hospitals to determine the prevalence of CRN and other colorectal diseases. In the group with an unknown source of infection, 61 patients (56%) underwent colonoscopy; of these, 31 (50.8%) had CRN. Nonadvanced colorectal adenoma was detected in 22 patients (36%), advanced adenoma in 5 (8.2%), and colorectal carcinoma (CRC) in 4 (6.6%). Among patients who survived the EFIE episode with ≥ 2 years of follow-up, 1 case of CRC was subsequently diagnosed. Only 6 patients (13.3%) with an identified focus of infection underwent colonoscopy; 1 of these patients (16.7%) was diagnosed with CRN. The prevalence of adenomas was slightly higher than that of the Spanish population in the same age range, whereas that of CRC was 17-fold higher. CRN was found in more than half of patients with EFIE and an unclear focus of infection who underwent colonoscopy. Colonoscopy should be recommended in patients with EFIE and an unclear source of infection. Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  6. Infliximab, an anti-TNF-alpha agent, improves left atrial abnormalities in patients with rheumatoid arthritis: preliminary results.

    PubMed

    Çetin, Süha; Süha, Çetin; Mustafa, Gökhan; Gökhan, Vural Mustafa; Keskin, Göksal; Göksal, Keskin; Yeter, Ekrem; Ekrem, Yeter; Doğan, Mehmet; Mehmet, Doğan; Öztürk, Mehmet Akif; Akif, Öztürk Mehmet

    2014-01-01

    Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality. In the current prospective study, we addressed the impact of RA on left atrial (LA) function and electrical remodelling. Further, we tried to demonstrate the effects of infliximab, an anti-TNF-alpha agent, on echocardiographical LA abnormality in RA patients with preserved left ventricular (LV) ejection fraction. We compared 38 female RA patients without clinical evidence of heart disease and 30 female controls without RA and clinical evidence of heart disease. Further, we compared RA patients receiving infliximab and increasing doses of prednisolone over a three-month period. At baseline and post treatment, this study assessed (1) LA and LV parameters using conventional and speckle tracking echocardiography (STE), and (2) electrocardiographic P-wave changes. The values of C-reactive protein (CRP), isovolumic relaxation time (IVRT), A wave, and deceleration time (DT) were significantly higher in RA patients compared to the control group (p < 0.05), whereas E/E' and E/A values were found to be lower (p < 0.05) in RA patients. E/E' values were lower in prednisolone- compared to infliximab-treated patients (p < 0.05). After three months of infliximab and prednisolone treatment, CRP and disease activity score (DAS 28) values decreased in both groups (p < 0.05), and Duke activity status index (DASI) increased (p < 0.05). Maximal left atrial volume index (LAVImax), pre-contraction left atrial volume index (LAVIpreA) and maximum P wave (Pmax) of the RA patients were higher compared to the control group (p < 0.05), whereas LA global strain was found to be lower (p < 0.05). There was no difference in Pmax values between groups before and after the treatment period. E/E', LAVImax and LAVIpreA values of infliximab-treated patients decreased and LA global strain increased after three months of therapy compared to baseline (p < 0.05). At baseline in both treatment groups, E/E' and LA

  7. Polarized electrons in ELSA (preliminary results)

    NASA Astrophysics Data System (ADS)

    Nakamura, S.; von Drachenfels, W.; Durek, D.; Frommberger, F.; Hoffmann, M.; Husmann, D.; Kiel, B.; Klein, F. J.; Menze, D.; Michel, T.; Nakanishi, T.; Naumann, J.; Reichelt, T.; Steier, C.; Toyama, T.; Voigt, S.; Westermann, M.

    1998-01-01

    Polarized electrons have been accelerated in the electron stretcher accelerator ELSA for the first time. Up to 2.1 GeV the polarization of the electron beam supplied by the 120 keV polarized electron source has been measured with a Mo/ller polarimeter. Preliminary results of polarization measurements at high energies and the performance of the source are presented.

  8. The ACT Alert: preliminary results of a novel protocol to assess geriatric head trauma patients on anticoagulation.

    PubMed

    Rittenhouse, Katelyn; Rogers, Amelia; Clark, Elizabeth; Horst, Michael; Adams, William; Bupp, Katherine; Shertzer, Weston; Miller, Jo Ann; Chandler, Roxanne; Rogers, Frederick B

    2015-04-01

    In busy emergency departments (EDs), elderly patients on anticoagulation (AC) sustaining minor injuries who are triaged to a lower priority for evaluation are at risk for potentially serious consequences. We sought to determine if a novel ED protocol prioritizes workup and improves outcome. In a Pennsylvania-verified Level II trauma center, the ACT (AntiCoagulation and Trauma) Alert was implemented in March 2012. Triage parameters include: age 65 years or older, AC agents, Glasgow Coma Score (GCS) 13 or greater, and head trauma 24 hours or less. ACT Alerts are announced overhead in the ED and require assessment by an ED physician, nurse, and phlebotomist in 15 minutes or less. Furthermore, they necessitate Point of Care international normalized ratio (INR) 20 minutes or less and head computed tomography (CT) scan 30 minutes or less. Positive CT findings mandate trauma service consultation. ACT Alert patients from March to December 2012 were compared with ED patients 65 years or older, GCS 13 or greater, on AC with the same chief complaints as ACT Alerts from June 2011 to February 2012 (control). A P value ≤ 0.05 was considered significant. Of 752 study patients, 415 were ACT and 337 were controls. There were no significant differences between groups in age, elevated INR, or head bleeds. ACT patients had significantly shorter median times from ED arrival to INR (ACT 13 minutes vs control 80 minutes; P < 0.001) and to head CT (ACT 35 minutes vs control 65 minutes; P < 0.001). Of admitted patients, ACT had a significantly shorter median length of stay (LOS) (ACT 3.7 days vs control 5.0 days; P < 0.001). Although trends toward improved outcome were noted, no statistically significant differences were identified. The ACT Alert improves ED throughput and reduces hospital LOS while effectively identifying at-risk, mildly head injured geriatric patients on AC.

  9. Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study

    PubMed Central

    Xu, Yaping; Zheng, Yuanda; Sun, Xiaojiang; Yu, Xinmin; Gu, Jialei; Wu, Wei; Zhang, Gu; Hu, Jinlin; Sun, Wenyong; Mao, Weimin

    2015-01-01

    The survival rate associated with esophageal cancer is very poor due to diagnosis at advanced stages of disease and insensitivity to chemotherapy. This study investigated the efficacy of gefitinib combination with radiation in 20 elderly patients with esophageal squamous cell carcinoma (ESCC) who were not eligible for platinum-based chemotherapy. Immunohistochemistry was performed to analyze epidermal growth factor receptor (EGFR) expression, and the amplified refractory mutation system was used to detect EGFR mutations. Treatment response was assessed by endoscopy and computed tomography. Treatment toxicity was evaluated using the National Cancer Institute's Common Toxicity Criteria. The data showed that among these 20 patients, 5 experienced a complete response (CR), 13 a partial response (PR), and 2 had stable disease. The overall response rate (CR + PR) was 90%, the median overall survival (OS) was 14.0 months (95% confidence interval [CI]: 10.0–17.9 months), and the median progression-free survival was 7.0 months (95% CI: 0–17.2 months). Patients with good Eastern Cooperative Oncology Group performance status, never smoking, and EGFR mutated tumors had the best OS (14.0, 14.0, and 17.0 months, respectively). Treatment-related grade 3/4 toxicity occurred in five patients. No case of grade 3/4 impaired liver function or hematological toxicity was observed. Concurrent radiotherapy with gefitinib is effective and tolerable in elderly ESCC patients. PMID:26392415

  10. Participation restrictions in patients with psychiatric and/or cognitive disabilities: preliminary results for an ICF-derived assessment tool.

    PubMed

    Belio, C; Prouteau, A; Koleck, M; Saada, Y; Merceron, K; Dayre, E; Destaillats, J M; Barral, C; Mazaux, J M

    2014-03-01

    Participation in community life is a major challenge for most people with psychiatric and/or cognitive disabilities. Current assessments of participation lack a theoretical basis. However, the new International Classification of Functioning, Disability and Health (ICF) provides a relevant framework. The present study used an ICF-derived assessment tool to activity limitations and participation restrictions in two groups of participants with disabilities linked to schizophrenia or traumatic brain injury respectively. Twenty-six items (related to six ICF sections) were selected by reviewing the literature and gathering the clinician's opinions and representatives of patient associations. These items, yielded an ordinal rating of activity limitations, participation restrictions and contextual factors (social support, attitudes and, systems & politics). Special attention was paid to contextual and environmental factors. The final checklist (called the Grid for Measurements of Activity and Participation, G-MAP) was administered to 16 participants with traumatic brain injury (the TBI group) and 15 participants with schizophrenic disorders (the SD group). Psychometric assessments of cognition and, neurobehavioural, psychological and psychosocial functioning were also performed. The internal consistencies for activity limitations (Cronbach's alpha coefficient=0.89) and participation restriction (Cronbach's alpha coefficient=0.89) were satisfactory. We did not observe any significant differences between the two groups in terms of the psychometric test results. The G-MAP scores demonstrated that the two groups were confronted with the same limitations in self care, domestic life, leisure and community life (i.e., the intergroup differences were not statistically significant in Mann-Whitney tests). However, interpersonal relationships and economic and social productivity appeared to be more severely limited in the SD group than in the TBI group. Similarly, participation

  11. Improved quality of life in patients with malignant pleural effusion following videoassisted thoracoscopic talc pleurodesis. Preliminary results.

    PubMed

    Basso, Stefano M M; Mazza, Francesco; Marzano, Bernardo; Santeufemia, Davide A; Chiara, Giordano B; Lumachi, Franco

    2012-11-01

    Malignant pleural effusion (MPE) is a common, debilitating complication of several types of advanced malignancy, which may significantly reduce the quality of life of patients. There are several options to treat MPE, including thoracentesis, placement of a long-term indwelling pleural catheter and chemical pleurodesis. The best treatment is still debated, but talc remains the agent of choice to achieve pleurodesis. Forty-six patients (28 men and 18 women; median age 67 years, range 47-82 years) with MPE related to different malignancies underwent video-assisted thoracoscopy talc pleurodesis. There were 26 (56.5%) patients with non-small cell lung cancer, 8 (17.4%) with breast cancer, 7 (15.2%) with pleural mesothelioma and 5 (10.9%) with other malignancies. The average operative time was 28±8 minutes, and the duration of chest tube drainage was 9.4±4.1 days. Side-effects were mild (temporary pain, fever for 2-3 days), affecting only three (12%) patients. Two patients (8%) died during hospitalization, due to progression of disease. Overall, pre- and postoperative Karnofsky performance index (KI) and Medical Research Council (MRC) dyspnea score were 62.1±12.2 vs. 71.3±13.2 (p=0.014), and 4.2±0.8 vs. 2.7±1.0 (p<0.001), respectively. A significant relationship between total amount of preoperative pleural effusion and both KI (R=-0.54, p=0.002) and MRC (R=0.64, p=0.0001) was found. No correlation (p=NS, log-rank test) was found between preoperative KI or MRC and underlying malignancy related to MPE. In conclusion, thoracoscopic large-particle talc pleurodesis is a feasible and effective treatment for MPE, significantly improving quality of life of patients.

  12. Sonographic parenchymal and brain perfusion imaging: preliminary results in four patients following decompressive surgery for malignant middle cerebral artery infarct.

    PubMed

    Schlachetzki, F; Hoelscher, T; Dorenbeck, U; Greiffenberg, B; Marienhagen, J; Ullrich, O W; Bogdahn, U

    2001-01-01

    To investigate new methods of diagnostic transcranial sonography for brain parenchymal, vascular and perfusion imaging, we performed 3-D native tissue harmonic transcranial sonography (3D-nthTCS), 3-D transcranial color-coded duplex sonography (3D-TCCS), and "loss-of-correlation" imaging (LOC-TCCS) in four patients following early hemicraniectomy due to space-occupying "malignant" middle cerebral artery infarction (MMCAI). Three-dimensional datasets, utilizing 3D-nthTCS and 3D-TCCS, were created and up to 10 axial 2-D B-mode image planes, similar to CCT, reconstructed in each patient. Three-dimensional reconstructions of the circle of Willis documented one persistent carotid-T occlusion and three recanalizations of the MCA. LOC-TCCS, based on stimulated acoustic emission from an ultrasound (US) contrast agent, demonstrated a perfusion deficit in 2 of 3 patients, with regard to their infarcts. Concluding, 3D-nthTCS, 3D-TCCS and LOC-TCCS are promising tools for bedside monitoring, early prognosis and treatment evaluation for MMCAI in the postoperative period. Further studies should be performed to standardize these new methods and evaluate their applications through the intact calvarina.

  13. Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry.

    PubMed

    Brola, Waldemar; Sobolewski, Piotr; Fudala, Małgorzata; Flaga, Stanisław; Jantarski, Konrad; Ryglewicz, Danuta; Potemkowski, Andrzej

    2016-01-01

    The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry. This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL. The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876-0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924-1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224-0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160-0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient's education, and marital status. The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy.

  14. An integrated gait rehabilitation training based on Functional Electrical Stimulation cycling and overground robotic exoskeleton in complete spinal cord injury patients: Preliminary results.

    PubMed

    Mazzoleni, S; Battini, E; Rustici, A; Stampacchia, G

    2017-07-01

    The aim of this study is to investigate the effects of an integrated gait rehabilitation training based on Functional Electrical Stimulation (FES)-cycling and overground robotic exoskeleton in a group of seven complete spinal cord injury patients on spasticity and patient-robot interaction. They underwent a robot-assisted rehabilitation training based on two phases: n=20 sessions of FES-cycling followed by n= 20 sessions of robot-assisted gait training based on an overground robotic exoskeleton. The following clinical outcome measures were used: Modified Ashworth Scale (MAS), Numerical Rating Scale (NRS) on spasticity, Penn Spasm Frequency Scale (PSFS), Spinal Cord Independence Measure Scale (SCIM), NRS on pain and International Spinal Cord Injury Pain Data Set (ISCI). Clinical outcome measures were assessed before (T0) after (T1) the FES-cycling training and after (T2) the powered overground gait training. The ability to walk when using exoskeleton was assessed by means of 10 Meter Walk Test (10MWT), 6 Minute Walk Test (6MWT), Timed Up and Go test (TUG), standing time, walking time and number of steps. Statistically significant changes were found on the MAS score, NRS-spasticity, 6MWT, TUG, standing time and number of steps. The preliminary results of this study show that an integrated gait rehabilitation training based on FES-cycling and overground robotic exoskeleton in complete SCI patients can provide a significant reduction of spasticity and improvements in terms of patient-robot interaction.

  15. Magnetic resonance imaging (MRI) of inflamed myocardium using iron oxide nanoparticles in patients with acute myocardial infarction - preliminary results.

    PubMed

    Yilmaz, Ali; Rösch, Sabine; Klingel, Karin; Kandolf, Reinhard; Helluy, Xavier; Hiller, Karl-Heinz; Jakob, Peter M; Sechtem, Udo

    2013-02-20

    Superparamagnetic iron oxide nanoparticle (SPIO)-based molecular imaging agents targeting macrophages have been developed and successfully applied in animal models of myocardial infarction. The purpose of this clinical trial was to investigate whether magnetic resonance imaging (MRI) of macrophages using ferucarbotran (Resovist®) allows improved visualisation of the myocardial (peri-)infarct zone compared to conventional gadolinium-based necrosis/fibrosis imaging in patients with acute myocardial infarction. The clinical study NIMINI-1 was performed as a prospective, non-randomised, non-blinded, single agent phase III clinical trial (NCT0088644). Twenty patients who had experienced either an acute ST-elevation or non-ST-elevation myocardial infarction (STEMI/NSTEMI) were included to this study. Following coronary angiography, a first baseline cardiovascular magnetic resonance (CMR) study (pre-SPIO) was performed within seven days after onset of cardiac symptoms. A second CMR study (post-SPIO) was performed either 10 min, 4h, 24h or 48h after ferucarbotran administration. The CMR studies comprised cine-CMR, T2-weighted "edema" imaging, T2-weighted cardiac imaging and T1-weighted late-gadolinium-enhancement (LGE) imaging. The median extent of short-axis in-plane LGE was 28% (IQR 19-31%). Following Resovist® administration the median extent of short-axis in-plane T2-weighted hypoenhancement (suggestive of intramyocardial haemorrhage and/or SPIO accumulation) was 0% (IQR 0-9%; p=0.68 compared to pre-SPIO). A significant in-slice increase (>3%) in the extent of T2-weighted "hypoenhancement" (post-SPIO compared to pre-SPIO) was seen in 6/16 patients (38%). However, no patient demonstrated "hypoenhancement" in T2-weighted images following Resovist® administration that exceeded the area of LGE. T2/T2-weighted MRI aiming at non-invasive myocardial macrophage imaging using the approved dose of ferucarbotran does not allow improved visualisation of the myocardial (peri

  16. Clinical improvement in patients with borderline personality disorder after treatment with repetitive transcranial magnetic stimulation: preliminary results.

    PubMed

    Reyes-López, Julian; Ricardo-Garcell, Josefina; Armas-Castañeda, Gabriela; García-Anaya, María; Arango-De Montis, Iván; González-Olvera, Jorge J; Pellicer, Francisco

    2017-06-12

    Current treatment of borderline personality disorder (BPD) consists of psychotherapy and pharmacological interventions. However, the use of repetitive transcranial magnetic stimulation (rTMS) could be beneficial to improve some BPD symptoms. The objective of this study was to evaluate clinical improvement in patients with BPD after application of rTMS over the right or left dorsolateral prefrontal cortex (DLPFC). Twenty-nine patients with BPD from the National Institute of Psychiatry, Mexico, were randomized in two groups to receive 15 sessions of rTMS applied over the right (1 Hz, n=15) or left (5 Hz, n=14) DLPFC. Improvement was measured by the Clinical Global Impression Scale for BPD (CGI-BPD), Borderline Evaluation of Severity Over Time (BEST), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A), and Barratt Impulsiveness Scale (BIS). Intragroup comparison showed significant (p < 0.05) reductions in every psychopathologic domain of the CGI-BPD and in the total scores of all scales in both groups. Both protocols produced global improvement in severity and symptoms of BPD, particularly in impulsiveness, affective instability, and anger. Further studies are warranted to explore the therapeutic effect of rTMS in BPD. NCT02273674

  17. The ChQoL questionnaire: an Italian translation with preliminary psychometric results for female oncological patients.

    PubMed

    Aschero, Giovanni; Fenoglio, Flavio; Vidili, Maria Giuseppina; Wussler, Andrea

    2010-09-25

    in Occidental languages, no widely accepted questionnaire is available which deals with health related quality of life from the specific point of view of Traditional Chinese Medicine (TCM). Some psychometric tools of this kind are available in Chinese. One of them is the Chinese Quality of Life questionnaire (ChQoL). It comprises 50 items, subdivided in 3 Domains and 13 Facets. The ChQoL was built from scratch on the basis of TCM theory. It is therefore specifically valuable for the TCM practitioner. This paper describes our translation into Italian of the ChQoL, its first application to Occidental oncological patients, and some of its psychometric properties. a translation scheme, originally inspired by the TRAPD procedure, is developed. This scheme focuses on comprehensibility and clinical usefulness more than on linguistic issues alone. The translated questionnaire is tested on a sample of 203 consecutive female patients with breast cancer. Shapiro-Wilk normality tests, Fligner-Killeen median tests, exploratory Two-step Cluster Analysis, and Tukey's test for non-additivity are applied to study the outcomes. an Italian translation is proposed. It retains the TCM characteristics of the original ChQoL, it is intelligible to Occidental patients who have no previous knowledge of TCM, and it is useful for daily clinical practice. The score distribution is not Normal, and there are floor and ceiling effects. A Visual Analogue Scale is identified as a suitable choice. A 3-point Likert scale can also efficiently describe the data pattern. The original scales show non-additivity, but an Anscombe-Tukey transformation with γ = 1.5 recovers additivity at the Domain level. Additivity is enhanced if different γ are adopted for different Facets, except in one case. the translated questionnaire can be adopted both as a filing system based on TCM and as a source of outcomes for clinical trials. A Visual Analogue Scale is recommended, but a simpler 3-point Likert scale also

  18. Quality of health care and patient satisfaction in liver disease: The development and preliminary results of the QUOTE-Liver questionnaire

    PubMed Central

    Gutteling, Jolie J; de Man, Robert A; Busschbach, Jan JV; Darlington, Anne-Sophie E

    2008-01-01

    Background Consensus on how to adequately measure patient satisfaction with health care is limited, and has led to the development of many questionnaires with various methodological problems. The objective of this study was to develop a liver disease- and care-specific patient satisfaction instrument on the basis of previously tested methodology in patient satisfaction measurement, the so called QUOTE- series: Quality Of health care services Through the patients' Eyes. QUOTE methodology aims to standardise the measurement of satisfaction as the discrepancy between patients' needs, and the extent to which these needs are being met. Methods As part of the QUOTE methodology routine, 11 Patients with chronic liver disease from the Erasmus MC (Rotterdam, the Netherlands) participated in focus-group meetings on patient satisfaction with the provided service at the outpatient hepatology clinic. Twenty-eight other patients were invited to rank the items generated during the focus-group meetings according to importance. With this information, the QUOTE-Liver was constructed. Face validity, construct validity, content validity, and reliability of the newly developed questionnaire were assessed in a test sample of 152 patients with chronic liver disease. Results Two liver-disease specific, and the 18 items ranked as most important were included in the QUOTE-Liver. Face validity and content validity were acceptable: neither patients (n = 152) nor psychologists (n = 3) or a hepatologist suggested any extra items to be included. Construct validity was good: the overall score correlated significantly with the Visual Analogue Scale (VAS) measuring overall satisfaction (r = 0.69, p < 0.01). The reliability of the QUOTE-Liver was excellent (α = 0.90). Conclusion The QUOTE-Liver is an easy to complete instrument based on standardized state-of-the-art satisfaction measurement methodology. Preliminary evidence for its validity and reliability was demonstrated. The QUOTE-liver covers

  19. [European Union Network for Patient Safety and Quality of Care (PASQ). Development and preliminary results in Europe and in the Spanish National Health System].

    PubMed

    Agra-Varela, Y; Fernández-Maíllo, M; Rivera-Ariza, S; Sáiz-Martínez-Acitorez, I; Casal-Gómez, J; Palanca-Sánchez, I; Bacou, J

    2015-01-01

    The joint action, European Union Network for Patient Safety and Quality of Care: PaSQ, aims to promote patient safety (PS) in the European Union (EU) and to facilitate the exchange of experiences among Member States (MS) and stakeholders on issues related to quality of care, PS, and patient involvement. The development and preliminary results are presented here, especially as regards the Spanish National Health System (SNHS). PaSQ is developed through 7 work packages, primarily aimed at sharing good practices (GP), which were identified using specific questionnaires and selected by means of explicit criteria, as well as to implement safe clinical practices (SCP) of proven effectiveness and agreed among MS. A total of 482 GP (39% provided by Spanish professionals) were identified. The 34 events organised in the EU, 11 including Spanish participation, facilitate sharing these practices. A total of 194 Health Care centres (49% in Spain) are implementing SCP (hand hygiene, safe surgery, medication reconciliation, and paediatric early warning scores) ACHIEVEMENTS AND FUTURE PERSPECTIVES: PaSQ is making it possible to strengthen collaboration between organizations and professionals at EU and SNHS level regarding PS and quality of care. Copyright © 2015 SECA. Published by Elsevier Espana. All rights reserved.

  20. Vibration of a rolling wheel— preliminary results

    NASA Astrophysics Data System (ADS)

    Hemsworth, B.

    1983-03-01

    Preliminary results are presented of the axial vibration of a railway wheel on a vehicle travelling at speeds of up to 100 miles/h. Frequency analysis shows that the wheel response is resonant, at modes of vibration which have been identified from static tests. Further developments of measurement and analysis techniques will be necessary before a more complete picture of the importance of wheel vibration on wheel/rail noise radiation can be determined.

  1. Interferometer experiment on nimbus 3: preliminary results.

    PubMed

    Hanel, R; Conrath, B

    1969-09-19

    A Michelson interferometer spectrometer carried aboard the Nimbus 3 satellite, launched 14 April 1969, measured the spectrum between 400 and 2000 wave numbers with a resolution of 5 wave numbers. High-quality spectra have been obtained on a global scale, and preliminary results indicate that the absorption bands of carbon dioxide, water vapor, and ozone can be used to obtain vertical distributions of temperature, water vapor, and ozone.

  2. Gender Differences in Remission and Recovery of Schizophrenic and Schizoaffective Patients: Preliminary Results of a Prospective Cohort Study

    PubMed Central

    Carpiniello, Bernardo; Pinna, Federica; Tusconi, Massimo; Zaccheddu, Enrico; Fatteri, Francesca

    2012-01-01

    The aim of the paper was to evaluate rates of clinical remission and recovery according to gender in a cohort of chronic outpatients attending a university community mental health center who had been diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV-TR. A sample of 100 consecutive outpatients (70 males and 30 females) underwent comprehensive psychiatric evaluation using the Structured Clinical Interview for Diagnosis of Axis I and II DSM-IV (SCID-I and SCID-II, Version R) and an assessment of psychopathology, social functioning, clinical severity, subjective wellbeing, and quality of life, respectively by means of PANSS (Positive and Negative Syndrome Scale), PSP (Personal and Social Performance), CGI-SCH (Clinical Global Impression—Schizophrenia scale), SWN-S (Subjective Well-being under Neuroleptics—scale), and WHOQOL (WHO Quality of Life). Rates of clinical remission and recovery according to different criteria were calculated by gender. Higher rates of clinical remission and recovery were generally observed in females than males, a result consistent with literature data. Overall findings from the paper support the hypothesis of a better outcome of the disorders in women, even in the very long term. PMID:22966440

  3. Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial.

    PubMed

    Morrison, C Anne; Carrick, Matthew M; Norman, Michael A; Scott, Bradford G; Welsh, Francis J; Tsai, Peter; Liscum, Kathleen R; Wall, Matthew J; Mattox, Kenneth L

    2011-03-01

    reduction in blood product transfusions and overall IV fluid administration. Specifically, resuscitating patients with the intent of maintaining a target minimum MAP of 50 mm Hg, rather than 65 mm Hg, significantly decreases postoperative coagulopathy and lowers the risk of early postoperative death and coagulopathy. These preliminary results provide convincing evidence that support the continued investigation and use of hypotensive resuscitation in the trauma setting. Copyright © 2011 by Lippincott Williams & Wilkins

  4. Preliminary Results from the CHIPS Mission

    NASA Astrophysics Data System (ADS)

    Hurwitz, M.; Sasseen, T.; Marchant, W.; Sirk, M.; UC Berkeley CHIPS Instrument Team; SpaceDev Inc. CHIPS Spacecraft Team

    2003-03-01

    We present preliminary results from the Cosmic Hot Interstellar Plasma Spectrometer (``CHIPS") mission. CHIPS contains a grazing incidence spectrometer optimized for diffuse emission in the extreme ultraviolet band between 90 and 260 Angstroms, with a peak resolution of about 1.4 Angstroms. The spectrometer should provide unique and important new data on hot gas within the ``local bubble" of the interstellar medium. At the time this abstract was submitted, CHIPS had been successfully launched into a polar orbit, but commissioning of the spacecraft had only just begun. CHIPS is supported by NASA grant NAG5-5213.

  5. Stereoplotting Hominid Brain Endocasts : Some Preliminary Results

    NASA Astrophysics Data System (ADS)

    Holloway, Ralph L.

    1980-07-01

    To objectively and quantitatively demonstrate regional differences in brain endocast morphology, traditional anthropometric caliper measurements must be replaced by a system providing not only localness, but homology and reasonable freedom from allometric distortion. Stereoplotting the radial distances from endocast surface (the closest point to the once underlying brain cortex) to a homologous center every ten degrees provides some 300+ data points for each dorsal endocast surface, thus giving the requisite localness. These measurements provide a large matrix of data suitable for a number of multivariate statistical techniques, and the translation of such data and analyses to readily visualized maps, which can then be compared in relation to both taxonomic and functional knowledge about the cerebral surface. This paper descri-bes some preliminary results from using such methods on a sample of 64 undistorted endocasts composed of both pongids and fossil hominids. While sample sizes within taxonomic groups need to be augmented, the preliminary and tentative pilot studies conducted so far suggest that the method has excellent potential, and that two major areas of the brain endocast surface show the greatest shape changes : 1) the posterior association areas (inferior parietal lobule); 2) the anterior prefrontal areas.

  6. Pioneer Saturn infrared radiometer - Preliminary results

    NASA Technical Reports Server (NTRS)

    Ingersoll, A. P.; Neugebauer, G.; Orton, G. S.; Muench, G.; Chase, S. C.

    1980-01-01

    Preliminary results of the infrared radiometer experiment on Pioneer Saturn are reported. The instrument made use of two broadband channels centered at 20 and 45 microns which scan at a fixed 75-deg angle with respect to the spacecraft spin axis to acquire 10,000 image pairs of Saturn and its rings in the 2.5 h before closest approach, as well as several observations of Titan. The intensities of radiation observed in both bands indicate an effective temperature of 94.4 + or - 3 K for the planet, implying a total emission greater than twice the absorbed sunlight. Infrared data also indicates a molecular abundance of 0.85 for H2 relative to H2 + He, which can be improved by comparing the derived temperature profiles and radio occultation data. Planetary temperatures are found to range from a minimum of 83 to 140 K at the 1 bar level, with differences of 2.5 K between belts and zones up to the 0.06-bar level, while ring temperatures range from 60 to 70 K on the illuminated side and from less than 60 to 67 K in the planet's shadow and average 55 K on the unilluminated side. Preliminary estimates indicate a 45-micron brightness temperature of 80 + or - 10 K for Titan.

  7. Improving recognition of patients at risk in a Portuguese general hospital: results from a preliminary study on the early warning score

    PubMed Central

    2014-01-01

    Background Early warning score (EWS) is a system that assists in the timely recognition of hospitalized patients outside critical care areas with potential or established critical illness at risk of deteriorating and who may be receiving suboptimal care. No such systems have been implemented in Portuguese National Health Service's wards. We performed a preliminary study to assess the potential outcome of applying the EWS in our hospital setting. Methods An observational retrospective study was conducted based on 100 patients assessed by the outreach team due to an acute event. The EWS was calculated a posteriori on three preceding periods from the acute deterioration (−12, −24, and −72 h). Results In 35 patients, there was insufficient recording of vital signs. The final sample of 65 patients includes 62.0% men, and the mean age (±SD) was 67 ± 16 years old. Respiratory problems were the main cause of deterioration (44.6%). The EWS score increased from −72 to −12 h. More than half of cases (63.0%) were admitted into high care units, and their mean (±SD) score was higher in comparison to those remaining in general wards (Intermediate Care Units 3.75 ± 1.9, Intensive Care Units 4.2 ± 1.5, wards 3.5 ± 1.4). Score at −24 and −12 h seemed to predict length of stay (LoS; p < 0.05) and mortality, respectively. The EWS would have incremented early medical attention by 40.0% if a threshold of ≥3 was used. Conclusions EWS systems are not widely used in Portuguese health service. Our data suggests that the EWS would allow early recognition for a higher number of patients in comparison to current ward care. Clinical worsening, lengths of stay, admission into high care units, and mortality may be predicted by the EWS. Prospective studies with multivariable analysis are needed to clarify the global outcome of the EWS implementation in national wards. PMID:25635187

  8. Preliminary results from MERIS Land Algorithm

    NASA Astrophysics Data System (ADS)

    Gobron, N.; Pinty, B.; Taberner, M.; Melin, F.; Verstraete, M. M.; Widlowski, J.-L.

    2003-04-01

    This paper presents a first and preliminary evaluation of the performance of the algorithm implemented in the Medium Resolution Imaging Spectrometer (MERIS) ground segment for assessing the status of land surfaces. First, we propose an updated version of the MERIS algorithm itself, which improves the accuracy of the product. Second, we analyze the first results by inter-comparing the MERIS Global Vegetation Index (MGVI) to similar products derived from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) that are generated at the European Commission Joint Research Center (EC-JRC). The first evaluation between MERIS and SeaWiFS derived products is made using data acquired on the same day by both instruments. The results show acceptable agreement and the differences are well understood by radiation transfer model simulations.

  9. SLS-1 flight experiments preliminary significant results

    NASA Astrophysics Data System (ADS)

    1992-01-01

    Spacelab Life Sciences-1 (SLS-1) is the first of a series of dedicated life sciences Spacelab missions designed to investigate the mechanisms involved in the physiological adaptation to weightlessness and the subsequent readaptation to 1 gravity (1 G). Hypotheses generated from the physiological effects observed during earlier missions led to the formulation of several integrated experiments to determine the underlying mechanisms responsible for the observed phenomena. The 18 experiments selected for flight on SLS-1 investigated the cardiovascular, cardiopulmonary, regulatory physiology, musculoskeletal, and neuroscience disciplines in both human and rodent subjects. The SLS-1 preliminary results gave insight to the mechanisms involved in the adaptation to the microgravity environment and readaptation when returning to Earth. The experimental results will be used to promote health and safety for future long duration space flights and, as in the past, will be applied to many biomedical problems encountered here on Earth.

  10. SLS-1 flight experiments preliminary significant results

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Spacelab Life Sciences-1 (SLS-1) is the first of a series of dedicated life sciences Spacelab missions designed to investigate the mechanisms involved in the physiological adaptation to weightlessness and the subsequent readaptation to 1 gravity (1 G). Hypotheses generated from the physiological effects observed during earlier missions led to the formulation of several integrated experiments to determine the underlying mechanisms responsible for the observed phenomena. The 18 experiments selected for flight on SLS-1 investigated the cardiovascular, cardiopulmonary, regulatory physiology, musculoskeletal, and neuroscience disciplines in both human and rodent subjects. The SLS-1 preliminary results gave insight to the mechanisms involved in the adaptation to the microgravity environment and readaptation when returning to Earth. The experimental results will be used to promote health and safety for future long duration space flights and, as in the past, will be applied to many biomedical problems encountered here on Earth.

  11. Breakthrough Propulsion Physics Workshop Preliminary Results

    NASA Technical Reports Server (NTRS)

    Millis, Marc G.

    1997-01-01

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop.

  12. Preliminary Proton Spin Asymmetry Results from SANE

    NASA Astrophysics Data System (ADS)

    Maxwell, James

    2010-11-01

    The Spin Asymetries of the Nucleon Experiment (SANE) is a measurement of parallel and near-perpendicular double spin asymmetries in an inclusive electron scattering experiment, with the aim of calculating the spin asymmetry of the proton A^1p and spin structure function g^2p. Using Thomas Jefferson National Accelerator Facility's polarized electron beam and the University of Virginia's polarized frozen ammonia (^14NH3) target in Hall C, the experiment ran in 2009, collecting data in a Q^2 region from 2.5 to 6.5 GeV^2 in a Bjorken x region of 0.3 to 0.8. Particle detection was accomplished using the Big Electron Telescope Array (BETA), a novel non-magnetic detector array with a 194 msr acceptance. This talk will address the progress of the analysis toward the calculation of the proton spin asymmetry and structure functions, including calibration of the BETA detectors, event selection, and preliminary results.

  13. Breakthrough propulsion physics workshop preliminary results

    SciTech Connect

    Millis, Marc G.

    1998-01-15

    In August, 1997, a NASA workshop was held to assess the prospects emerging from physics that might lead to creating the ultimate breakthroughs in space transportation: propulsion that requires no propellant mass, attaining the maximum transit speeds physically possible, and breakthrough methods of energy production to power such devices. Because these propulsion goals are presumably far from fruition, a special emphasis was to identify affordable, near-term, and credible research that could make measurable progress toward these propulsion goals. Experiments and theories were discussed regarding the coupling of gravity and electromagnetism, vacuum fluctuation energy, warp drives and wormholes, and superluminal quantum tunneling. Preliminary results of this workshop are presented, along with the status of the Breakthrough Propulsion Physics program that conducted this workshop.

  14. ESA's Biopan 1--"Vitamin" experiment preliminary results.

    PubMed

    Moatti, J P; Dousset, N; Moatti, N; Degre, M; Eche, B; Gasset, G; Tixador, R

    1995-01-01

    The purpose of "Vitamin" experiment is to study the efficiency of protective substances on three biological acellular systems aqueous solutions exposed to cosmic radiation in space. The first system "LDL" is a low density lipoprotein. The second is "E2-TeBG complexe" in which estradiol (E2) is bound to its plasmatic carrier protein, testosterone-estradiol binding globulin (TeBG). The third is "pBR 322", a plasmid. "Vitamin" experiment was accommodated in the Biopan which had been mounted on the outer surface of a Foton retrievable satellite. The experiment was exposed to space environment during 15 days. A stable temperature of about 2O degrees C was maintained throughout the flight. "Vitamin" experiment preliminary results are presented and discussed.

  15. Overweight and urban pollution: preliminary results.

    PubMed

    Ponticiello, Barnaba Giuseppina; Capozzella, Assunta; Di Giorgio, Valeria; Casale, Teodorico; Giubilati, Roberto; Tomei, Gianfranco; Tomei, Francesco; Rosati, Maria Valeria; Sancini, Angela

    2015-06-15

    The aim of this study is to determine whether in workers exposed to urban pollution the risk of developing overweight and obesity is higher in workers exposed to urban pollution compared to a control group. The study was conducted on 150 volunteers, 75 workers exposed to urban pollution (50 women and 25 men) and 75 indoor workers (50 women and 25 men). Once measured the weight and height and calculated body mass index (BMI) for each worker, the research was based on the comparison, between the two groups, of the mean values of the measurements and of the frequency of workers with BMI index higher than the cut-off of normality. The only statistically significant difference found was for the mean value of weight in women, which was higher among outdoor workers compared to indoor workers. The mean values of BMI and the frequency of workers with BMI higher than normal was higher among outdoor workers compared to indoor workers in both sexes, but not statistically significant. The data suggest that outdoor workers may be subject to an additional risk of developing obesity as a result of exposure to urban air pollution (which, like obesity, is a source of oxidative stress). So, our preliminary study encourages to continue this line of research by implementing the sample and considering all the confounding factors. Furthermore, the results highlight the necessity to take account of gender differences in the context of health surveillance of workers.

  16. Preliminary results from an advanced lighting controlstestbed

    SciTech Connect

    Avery, Douglas; Jennings, Judity; Rubinstein, Francis

    1998-03-01

    Preliminary results from a large-scale testbed of advanced lighting control technologies at the Phillip Burton Federal Building at 450 Golden Gate Ave. in San Francisco are presented. The first year objective of this project is to determine the sustainable energy savings and cost-effectiveness of different lighting control technologies compared to a portion of the building where only minimal controls are installed. The paper presents the analyzed results from six months of tests focused on accurately characterizing the energy savings potential of one type of daylight-linked lighting controls compared to the lighting in similar open-planned areas without dimming controls. After analyzing a half year;s data, we determined that the annual energy savings for this type of daylight- linked controls was 41% and 30% for the outer rows of lights on the South and North sides of the building, respectively. The annual energy savings dropped to 22% and 16% for the second row of lights for the South and North, respectively, and was negligible for the third rows of lights.

  17. The viking biological investigation: preliminary results.

    PubMed

    Klein, H P; Horowitz, N H; Levin, G V; Oyama, V I; Lederberg, J; Rich, A; Hubbard, J S; Hobby, G L; Straat, P A; Berdahl, B J; Carle, G C; Brown, F S; Johnson, R D

    1976-10-01

    Three different types of biological experiments on samples of martian surface material ("soil") were conducted inside the Viking lander. In the carbon assimilation or pyrolytic release experiment, (14)CO(2) and (14)CO were exposed to soil in the presence of light. A small amount of gas was found to be converted into organic material. Heat treatment of a duplicate sample prevented such conversion. In the gas exchange experiment, soil was first humidified (exposed to water vapor) for 6 sols and then wet with a complex aqueous solution of metabolites. The gas above the soil was monitored by gas chromatography. A substantial amount of O(2) was detected in the first chromatogram taken 2.8 hours after humidification. Subsequent analyses revealed that significant increases in CO(2) and only small changes in N(2) had also occurred. In the labeled release experiment, soil was moistened with a solution containing several (14)C-labeled organic compounds. A substantial evolution of radioactive gas was registered but did not occur with a duplicate heat-treated sample. Alternative chemical and biological interpretations are possible for these preliminary data. The experiments are still in process, and these results so far do not allow a decision regarding the existence of life on the plonet Mars.

  18. Preliminary test results for the SVX4

    SciTech Connect

    Christofek, L.; Hanagaki, K.; Rapidis, P.; Utes, M.; /Fermilab

    2005-06-01

    We present and summarize the preliminary test results for SVX4 chip testing. There are presently two versions of the SVX4. Version 2 has on-chip bypassing and Version 1 does not. The on-chip bypassing is a layer of transistors under the front-end analog pipeline that acts as a bypassing capacitor for the voltage supply. Its size is about a microfarad. We aggressively choose to test Version 2 because of this feature. The feature is advantageous for hybrid design because it eliminates the need for an additional passive component on the hybrid itself by placing it on the actual SVX4 die. Also, the SVX4 was designed to operate in two modes: D. and CDF. One can set which mode the chip will operate by placing a jumper in the proper position on the SVX4 chip carrier. In either mode, the chip can either use the operating parameters from the shift register or the shadow register. Similarly, this is selected by placing a jumper on the SVX4 chip carrier. This chip has this feature because it was unknown whether the new design of the shadow register would be operable. The shadow register is also call the SEU register or Single Event Upset register. An introduction into the functionality of the chip and an explanation on the difference between D. and CDF mode can be found in the SVX4 User's Manual [1].

  19. Mars Express Bistatic Radar: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Simpson, R. A.; Tyler, G. L.; Paetzold, M.

    2005-08-01

    Bistatic radar, conducted at microwave frequencies, can be a convenient and cost-effective method for probing planetary surfaces at centimeter scales - dimensions of interest in selecting lander and rover sites, for example. Half a dozen such experiments have been conducted using Mars Express in a new mode, which relies on relative echo strengths in two orthogonal polarizations rather than absolute calibration of a single polarization (see Simpson and Tyler, ICARUS 152, pp 70-74, 2001). Observations conducted to date have been limited to a fixed spacecraft attitude (inertial pointing); so dielectric constant estimates are valid at only one specular point per wavelength per experiment. Preliminary results have been obtained for Vastitas Borealis (64.1N, 60.1E), the southeast rim of Argyre (56.0S, 324.8E), and plains west of Argyre (51.0S, 289.4E). Dielectric constants are N/A and 2.7, 2.0 and 2.1, and 3.2 and 3.5 at the three sites at 3.5 and 13.1 cm wavelengths, respectively. These confirm spatial variability (while being within the nominal range for Mars) and show the expected lower values at shorter wavelengths.

  20. Preliminary Results of the MARE Experiment

    NASA Astrophysics Data System (ADS)

    Ferri, E.; Bagliani, D.; Biassotti, M.; Ceruti, G.; Corsini, D.; Faverzani, M.; Gatti, F.; Giachero, A.; Gotti, C.; Kilbourne, C.; Kling, A.; Kraft-Bermuth, S.; Maino, M.; Manfrinetti, P.; Nucciotti, A.; Pessina, G.; Pizzigoni, G.; Ribeiro Gomes, M.; Schaeffer, D.; Sisti, M.

    2014-09-01

    The microcalorimeter array for a rhenium experiment (MARE) project aims at the direct and calorimetric measurement of the electron neutrino mass with sub-eV sensitivity. The design is based on large arrays of thermal detectors to study the beta decay of Re and the electron capture of Ho. One of the activities of the project, MARE 1 in Milan, has started in Milan using one array of 6 6 silicon implanted thermistors equipped with AgReO absorbers. The purposes of MARE 1 in Milan are to achieve a sensitivity on the neutrino mass of a few eV and to investigate the systematics of Re neutrino mass measurements, focusing on those caused by the beta environmental fine structure and the beta spectrum theoretical shape. In parallel, the MARE collaboration is performing an R&D work for producing absorbers embedded with radioactive metal Ho. We report here the status of MARE using Re as beta source and the preliminary results obtained with Ho.

  1. Quality of health care and patient satisfaction in liver disease: the development and preliminary results of the QUOTE-Liver questionnaire.

    PubMed

    Gutteling, Jolie J; de Man, Robert A; Busschbach, Jan Jv; Darlington, Anne-Sophie E

    2008-06-20

    Consensus on how to adequately measure patient satisfaction with health care is limited, and has led to the development of many questionnaires with various methodological problems. The objective of this study was to develop a liver disease- and care-specific patient satisfaction instrument on the basis of previously tested methodology in patient satisfaction measurement, the so called QUOTE- series: Quality Of health care services Through the patients' Eyes. QUOTE methodology aims to standardise the measurement of satisfaction as the discrepancy between patients' needs, and the extent to which these needs are being met. As part of the QUOTE methodology routine, 11 Patients with chronic liver disease from the Erasmus MC (Rotterdam, the Netherlands) participated in focus-group meetings on patient satisfaction with the provided service at the outpatient hepatology clinic. Twenty-eight other patients were invited to rank the items generated during the focus-group meetings according to importance. With this information, the QUOTE-Liver was constructed. Face validity, construct validity, content validity, and reliability of the newly developed questionnaire were assessed in a test sample of 152 patients with chronic liver disease. Two liver-disease specific, and the 18 items ranked as most important were included in the QUOTE-Liver. Face validity and content validity were acceptable: neither patients (n = 152) nor psychologists (n = 3) or a hepatologist suggested any extra items to be included. Construct validity was good: the overall score correlated significantly with the Visual Analogue Scale (VAS) measuring overall satisfaction (r = 0.69, p < 0.01). The reliability of the QUOTE-Liver was excellent (alpha = 0.90). The QUOTE-Liver is an easy to complete instrument based on standardized state-of-the-art satisfaction measurement methodology. Preliminary evidence for its validity and reliability was demonstrated. The QUOTE-liver covers those aspects of satisfaction that

  2. Preliminary results of radiation measurements on EURECA

    SciTech Connect

    Benton, E.V.; Frank, A.L.

    1995-03-01

    The eleven-month duration of the EURECA mission allows long-term radiation effects to be studied similarly to those of the Long Duration Exposure Facility (LDEF). Basic data can be generated for projections to crew doses and electronic and computer reliability on spacecraft missions. A radiation experiment has been designed for EURECA which uses passive integrating detectors to measure average radiation levels. The components include a Trackoscope, which employs fourteen plastic nuclear track detector (PNTD) stacks to measure the angular dependence of high LET (greater than or equal to 6 keV/micro m) radiation. Also included are TLD`s for total absorbed doses, thermal/resonance neutron detectors (TRND`s) for low energy neutron fluences and a thick PNTD stack for depth dependence measurements. LET spectra are derived from the PNTD measurements. Preliminary TLD results from seven levels within the detector array show that integrated dose inside the flight canister varied from 18.8 +/- 0.6 cGy to 38.9 +/- 1.2 cGy. The TLD`s oriented toward the least shielded direction averaged 53% higher in dose than those oriented away from the least shielded direction (minimum shielding toward the least shielded direction varied from 1.13 to 7.9 g/cm(exp 2), Al equivalent). The maximum dose rate on EURECA (1.16 mGy/day) was 37% of the maximum measured on LDEF and dose rates at all depths were less than measured on LDEF. The shielding external to the flight canister covered a greater solid angle about the canister than the LDEF experiments.

  3. Global Geologic Mapping of Io: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Williams, David A.; Keszthelyi, L. P.; Crown, D. A.; Geissler, P. E.; Schenk, P. M.; Yff, Jessica; Jaeger, W. L.; Rathbun, J. A.

    2008-01-01

    A new global geologic map of Jupiter's volcanic moon, Io is being prepared, with the focus being on completion of a draft map by July 2008. Here initial results of the mapping are reported: a preliminary distribution of material units in terms of areas and a visual representation. Additionally, the mapping hopes to address some of the problems in Io geology. Thus far it has been discovered that Io's surface is dominated by plains material, thought to consist of Io's silicate crust covered by pyroclastic deposits and lava flows of silicate and sulfur-bearing composition. Many plains areas contain flow fields that cannot be mapped separately due to a lack of resolution or modification by alteration processes. Discrete lava flows and flow fields are the next most abundant unit, with bright (sulfur?) flows in greater abundance than dark (silicate?) flows. The source of most of Io's heat flow, the paterae, are the least abundant unit in terms of areal extent.Upon completion of the draft map for peer review, it will be used to investigate several specific questions about the geological evolution of Io that previously could not be well addressed, including: comparison of the areas versus the heights of Ionian mountains to assess their stability and evolution; correlation and comparison of Galileo Near-Infrared Mapping Spectrometer and Photopolarimeter-Radiometer hot spot locations with the mapped location of dark versus bright lava flows and patera floors to assess any variations in the types of sources for Io's active volcanism; and the creation of a global inventory of the areal coverage of dark and bright laval flows to assess the relative importance of sulfur versus silicate volcanism in resurfacing Io, and to assess whether there are regional concentrations of either style of volcanism that may have implications on interior processes.

  4. Tellurium in active volcanic environments: Preliminary results

    NASA Astrophysics Data System (ADS)

    Milazzo, Silvia; Calabrese, Sergio; D'Alessandro, Walter; Brusca, Lorenzo; Bellomo, Sergio; Parello, Francesco

    2014-05-01

    Tellurium is a toxic metalloid and, according to the Goldschmidt classification, a chalcophile element. In the last years its commercial importance has considerably increased because of its wide use in solar cells, thermoelectric and electronic devices of the last generation. Despite such large use, scientific knowledge about volcanogenic tellurium is very poor. Few previous authors report result of tellurium concentrations in volcanic plume, among with other trace metals. They recognize this element as volatile, concluding that volcanic gases and sulfur deposits are usually enriched with tellurium. Here, we present some results on tellurium concentrations in volcanic emissions (plume, fumaroles, ash leachates) and in environmental matrices (soils and plants) affected by volcanic emissions and/or deposition. Samples were collected at Etna and Vulcano (Italy), Turrialba (Costa Rica), Miyakejima, Aso, Asama (Japan), Mutnovsky (Kamchatka) at the crater rims by using common filtration techniques for aerosols (polytetrafluoroethylene filters). Filters were both eluted with Millipore water and acid microwave digested, and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Volcanic ashes emitted during explosive events on Etna and Copahue (Argentina) were analyzed for tellurium bulk composition and after leaching experiments to evaluate the soluble fraction of tellurium. Soils and leaves of vegetation were also sampled close to active volcanic vents (Etna, Vulcano, Nisyros, Nyiragongo, Turrialba, Gorely and Masaya) and investigated for tellurium contents. Preliminary results showed very high enrichments of tellurium in volcanic emissions comparing with other volatile elements like mercury, arsenic, thallium and bismuth. This suggests a primary transport in the volatile phase, probably in gaseous form (as also suggested by recent studies) and/or as soluble salts (halides and/or sulfates) adsorbed on the surface of particulate particles and ashes. First

  5. Bacteremia following dental implant surgery: Preliminary results

    PubMed Central

    Özdemir, Tayfun; Öksüz, Lütfiye; Gürler, Nezahat

    2012-01-01

    Objectives: The aims of this study were to investigate the incidence of bacteremia, bacteriology and antibiotic susceptibility against to causative bacteria associated with dental implant installation. Study Design: 30 generally healthy patients were enrolled in this study. Blood samples were collected at baseline and at 30 minutes after dental implant installation and 24 hours after dental implant surgery. Blood samples were cultured in a BACTEC system. The isolated bacteria were identified using conventional methods. Antimicrobial sensitivity tests were performed by disc diffusion. Results: No bacteria were isolated at the baseline and 24 hours after surgery, whereas the prevalence of bacteremia at 30 minutes after dental implant installation was 23%. The isolated bacteria species were Staphylococcus epidermidis, Eubacterium spp., Corynebacterium spp. and Streptococcus viridans. The Staphylococcus epidermidis, which was isolated in three patients, was found to be resistant to penicillin which is first choice of many clinicians. Conclusion: Our findings suggest that installation of dental implants can produce bacteremia. Within the limitations of this study, it can be speculated that the resistance of antibiotics may compromise the routine prophylaxis against infective endocarditis. Therefore use of blood cultures and antibiograms may be suggested in risky patients. The outcome of the present study should be verified using a larger patient group with varying conditions. Key words: Dental implant, bacteremia, infective endocarditis, antibiotic prophylaxis. PMID:22157668

  6. [Preliminary results of treatment with aflibercept].

    PubMed

    Blăjan, Codruta; Nicula, D; Rusu, Ioana

    2014-01-01

    The paper presents the first results concerning the Aflibercept (Eylea) treatment, the last antiVEGF approved for treatment of the age related macular degeneration (AMD), neovascular form and for macular edema due to the central retinal vein occlusion. The treatment was applied to patients presenting AMD, ME and other diseases: myopic and idiopatic choroidal neovascularisation, central serous choroidopathy (CSC) or diabetic macular edema (DME). The results were good: improvement of the visual acuity, resolution of the intraretinal fluids and macular edema. Although we did not notice major side-effects, resistance or tachyphylaxis, we noticed some recurrences.

  7. X-48B Preliminary Flight Test Results

    NASA Technical Reports Server (NTRS)

    Taylor, Brian R.

    2009-01-01

    This slide presentation reviews the preliminary Flight tests of the X-48B development program. The X-48B is a blended wing body aircraft that is being used to test various features of the BWB concept. The research concerns the following: (1) Turbofan Development, (2) Intelligent Flight Control and Optimization, (3) Airdata Calibration (4) Parameter Identification (i.e., Determination of the parameters of a mathematical model of a system based on observation of the system inputs and response.)

  8. [Prevalence of opportunistic digestive parasitic infections in Kinshasa, Democratic Republic of Congo. Results of a preliminary study in 50 AIDS patients].

    PubMed

    Wumba, R; Enache-Angoulvant, A; Develoux, M; Mulumba, A; Mulumba, P M; Hennequin, C; Odio, T W; Biligui, S; Sala, J; Thellier, M

    2007-04-01

    In the Democratic Republic of Congo (DRC), as in many African countries, AIDS and its procession of opportunistic infections are a major cause of morbidity and mortality. In Kinshasa, the estimated prevalence rate of HIV-infected persons is between 4 and 5%, corresponding to more than 200,000 people. Due to the lack of trained laboratory personnel and appropriate diagnostic equipment, no local investigation has been carried out to determine the prevalence of the opportunistic digestive parasitic infection in HIV-infected persons. As a step to obtaining this information that is needed for implementation of an adequate care policy, a preliminary investigation was carried out in Paris, France on 50 stool samples from 50 AIDS-patients hospitalized in 3 reference hospitals in Kinshasa. Eleven patients (22%) had digestive symptoms with a diarrhea syndrome. Further study using specialized techniques demonstrated 2 cases of digestive infection related to opportunistic parasites (4%). The first involved a Cryptosporidium sp. The second represented the first case of Enterocytozoon bieneusi infection reported in the literature from the DRC.

  9. Archaeogeophysical investigations in Tiwanaku: preliminary results

    NASA Astrophysics Data System (ADS)

    Masini, Nicola; Sileo, Maria; Lasaponara, Rosa; Leucci, Giovanni; Orefici, Giuseppe; Rizzo, Enzo

    2017-04-01

    -1450) Tiwanaku was characterized by the resurgence of regional identities and polities In spite of the rich archaeological record numerous issues, related to the function and the extension of Tiwanaku, need to be investigated especially in the monumental core which includes the pyramid of Akapana, and other ceremonial places such Kalasasaya, Putuni and Kantatallita. To this aims some geophysical investigations were performed in 2009 and 2014 in the context of multidisciplinary research including the use of satellite remote sensing [8]. This paper deals with the discussion of preliminary results of geomagnetic and GPR investigations, some of which have been verified by trial archaeological excavations which have unearthed some buried structures, improving the knowledge of the ceremonial areas of Tiwanaku. References [1] Lasaponara R., Leucci G., Masini N., Persico R., Scardozzi G., Towards an operative use of remote sensing for exploring the past using satellite data: The case study of Hierapolis (Turkey), Remote sensing of Environment, 174 (2016) : 148-164, doi:10.1016/j.rse.2015.12.016 [2] Masini N., Lasaponara R., Rizzo E., Orefici G. 2012. Integrated Remote Sensing Approach in Cahuachi (Peru): Studies and Results of the ITACA Mission (2007-2010), In: Lasaponara R., Masini N. (Eds) 2012, Satellite Remote Sensing: a new tool for Archaeology, Springer, Verlag Berlin Heidelberg, ISBN 978-90-481-8800-0, doi: 10.1007/978-90-481-8801-7_14; pp. 307-344 [3] Rizzo E., Masini N., Lasaponara R., Orefici G. 2010, ArchaeoGeophysical methods in the Templo del Escalonado (Cahuachi, Nasca, Perù), Near Surface Geophysics 8 (5), 433-439, doi:10.3997/1873-0604.2010030 [4] Masini N., Rizzo E., Lasaponara R., and Orefici G. 2008, Integrated remote sensing techniques for the detection of buried archaeological adobe structures: preliminary results in Cahuachi (Peru), Advances in Geosciences, 19, 75-82 [5] Lasaponara R., Leucci G., Masini N., Persico R. 2014. Investigating archaeological looting

  10. Preliminary impression techniques for microstomia patients

    PubMed Central

    Kumar, K. Aswini; Bhat, Vinaya; Nair, K. Chandrasekheran; Suresh, Reshma

    2016-01-01

    The Prosthetic rehabilitation of microstomia patients presents difficulties at all the stages. The difficulty starts with the preliminary impression making. This is due to the tongue rigidity and the decreased oral opening. A maximum oral opening which is smaller than the size of the tray can make prosthetic treatment challenging. Due to the restricted mouth opening, insertion and removal of the impression trays is extremely cumbersome and various modifications of the trays have been used in the past. Among these are the flexible trays and the sectional trays used with different modes of reassembling the segments extra orally after the impression is made. This article reviews the literature published from 1971 to 2015 concerning preliminary impression techniques used in making impressions for patients with microstomia based on various tray designs. An electronic search was performed across three databases (PubMed, Science Direct and Google Scolar) for relevant citations. The keywords/combinations used for the search were microstomia, limited/constricted/restricted mouth opening/oral access, trismus, sectional trays, impressions and prosthetic/prosthodontic rehabilitation. The search was limited to papers written in English which resulted in a total of 45 related articles of which 17 articles were included for discussion of this review. PMID:27621540

  11. Preliminary impression techniques for microstomia patients.

    PubMed

    Kumar, K Aswini; Bhat, Vinaya; Nair, K Chandrasekheran; Suresh, Reshma

    2016-01-01

    The Prosthetic rehabilitation of microstomia patients presents difficulties at all the stages. The difficulty starts with the preliminary impression making. This is due to the tongue rigidity and the decreased oral opening. A maximum oral opening which is smaller than the size of the tray can make prosthetic treatment challenging. Due to the restricted mouth opening, insertion and removal of the impression trays is extremely cumbersome and various modifications of the trays have been used in the past. Among these are the flexible trays and the sectional trays used with different modes of reassembling the segments extra orally after the impression is made. This article reviews the literature published from 1971 to 2015 concerning preliminary impression techniques used in making impressions for patients with microstomia based on various tray designs. An electronic search was performed across three databases (PubMed, Science Direct and Google Scolar) for relevant citations. The keywords/combinations used for the search were microstomia, limited/constricted/restricted mouth opening/oral access, trismus, sectional trays, impressions and prosthetic/prosthodontic rehabilitation. The search was limited to papers written in English which resulted in a total of 45 related articles of which 17 articles were included for discussion of this review.

  12. High intensity copper atom beam - Preliminary results

    NASA Technical Reports Server (NTRS)

    Kelly, A. J.; Santavicca, D.

    1973-01-01

    The development of a nozzle which gas-dynamically accelerates neutral copper atoms at controlled energy levels and flux rates suitable for the investigation of inelastic copper atom collision processes is reported. Preliminary test data demonstrate that vapor-deposited rhenium nozzles do not degrade in the presence of copper vapor at high temperatures. Operation with high purity helium gas at nozzle stagnation temperatures in the range 2650-2700 K and total stagnation pressures from 1/4 to 2 atm with continuous copper atom flux rates of approximately 10 to the 18th power per second has been maintained, for a total time of 8-1/2 h to date.

  13. Pioneer 10 infrared radiometer experiment: preliminary results.

    PubMed

    Chase, S C; Ruiz, R D; Münch, G; Neugebauer, G; Schroeder, M; Trafton, L M

    1974-01-25

    Thermal maps of Jupiter at 20 and 40 micrometers show structure closely related to the visual appearance of the planet. Peak brightness temperatures of 126 degrees and 145 degrees K have been measured on the South Equatorial Belt, for the 20- and 40-micrometer channels, respectively. Corresponding values for the South Tropical Zone are 120 degrees and 138 degrees K. No asymmetries between the illuminated sunlit and nonilluminated parts of the disk were found. A preliminary discussion of the data, in terms of simple radiative equilibrium models, is presented. The net thermal energy of the planet as a whole is twice the solar energy input.

  14. Study of cerebral ischemic reversibility: Part II. Preliminary preoperative results of fluoromethane positron emission tomographic determination of perfusion reserve in patients with carotid TIA and stroke

    SciTech Connect

    Levine, R.L.; Sunderland, J.J.; Rowe, B.R.; Nickles, R.J.

    1986-01-01

    Symmetries and asymmetries in regional cerebral blood flow (rCBF) determinations are reported in eleven patients with symptomatic carotid artery occlusive disease. Flourine-18-fluoromethane rCBF values are obtained by means of a noninvasive positron emission tomographic (PET) technique during room air (RA) and following induced hypercapnia (CO/sub 2/). Areas of abnormal CO/sub 2/ reactivity predict both the hemodynamic significance of the vascular lesion in question and the areas most vulnerable for ischemic infarction. This data is intended to be preliminary in nature; future expansions of this data base will be made to include rCBF/CO/sub 2/ estimations, rCBF/glucose metabolism determinations, and rCBF/reserve evaluations over time and following brain-specific therapies. Once established, the potential viability and reversibility of these ischemic, uninfarcted or minimally infarcted areas can then be reestablished over time, thus providing a quantitative measure of the natural history of flow/metabolic coupling or uncoupling.

  15. Improving recognition of patients at risk in a Portuguese general hospital: results from a preliminary study on the early warning score.

    PubMed

    Correia, Nuno; Rodrigues, Rui Paulo; Sá, Márcia Carvalho; Dias, Paula; Lopes, Luís; Paiva, Artur

    2014-01-01

    Early warning score (EWS) is a system that assists in the timely recognition of hospitalized patients outside critical care areas with potential or established critical illness at risk of deteriorating and who may be receiving suboptimal care. No such systems have been implemented in Portuguese National Health Service's wards. We performed a preliminary study to assess the potential outcome of applying the EWS in our hospital setting. An observational retrospective study was conducted based on 100 patients assessed by the outreach team due to an acute event. The EWS was calculated a posteriori on three preceding periods from the acute deterioration (-12, -24, and -72 h). In 35 patients, there was insufficient recording of vital signs. The final sample of 65 patients includes 62.0% men, and the mean age (±SD) was 67 ± 16 years old. Respiratory problems were the main cause of deterioration (44.6%). The EWS score increased from -72 to -12 h. More than half of cases (63.0%) were admitted into high care units, and their mean (±SD) score was higher in comparison to those remaining in general wards (Intermediate Care Units 3.75 ± 1.9, Intensive Care Units 4.2 ± 1.5, wards 3.5 ± 1.4). Score at -24 and -12 h seemed to predict length of stay (LoS; p < 0.05) and mortality, respectively. The EWS would have incremented early medical attention by 40.0% if a threshold of ≥3 was used. EWS systems are not widely used in Portuguese health service. Our data suggests that the EWS would allow early recognition for a higher number of patients in comparison to current ward care. Clinical worsening, lengths of stay, admission into high care units, and mortality may be predicted by the EWS. Prospective studies with multivariable analysis are needed to clarify the global outcome of the EWS implementation in national wards.

  16. Preliminary Results of Field Emission Cathode Tests

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Kovaleski, Scott D.

    2001-01-01

    Preliminary screening tests of field emission cathodes such as chemical vapor deposited (CVD) diamond, textured pyrolytic graphite, and textured copper were conducted at background pressures typical of electric thruster test facilities to assess cathode performance and stability. Very low power electric thrusters which provide tens to hundreds micronewtons of thrust may need field emission neutralizers that have a capability of tens to hundreds of microamperes. From current voltage characteristics, it was found that the CVD diamond and textured metals cathodes clearly satisfied the Fowler-Nordheim emission relation. The CVD diamond and a textured copper cathode had average current densities of 270 and 380 mA/sq cm, respectively, at the beginning-of-life. After a few hours of operation the cathode emission currents degraded by 40 to 75% at background pressures in the 10(exp -5) Pa to 10(exp -4) Pa range. The textured pyrolytic graphite had a modest current density at beginning-of-life of 84 mA/sq cm, but this cathode was the most stable of all. Extended testing of the most promising cathodes is warranted to determine if current degradation is a burn-in effect or whether it is a long-term degradation process. Preliminary experiments with ferroelectric emission cathodes, which are ceramics with spontaneous electric polarization, were conducted. Peak current densities of 30 to 120 mA/sq cm were obtained for pulse durations of about 500 ns in the 10(exp -4) Pa pressure range.

  17. MR elastography of breast cancer: preliminary results.

    PubMed

    McKnight, Alexia L; Kugel, Jennifer L; Rossman, Phillip J; Manduca, Armando; Hartmann, Lynn C; Ehman, Richard L

    2002-06-01

    Motivated by the long-recognized value of palpation in detecting breast cancer, we tested the feasibility of a technique for quantitatively evaluating the mechanical properties of breast tissues on the basis of direct MR imaging visualization of acoustic waves. The prototypic elasticity imaging technique consists of a device for generating acoustic shear waves in tissue, an MR imaging-based method for imaging the propagation of these waves, and an algorithm for processing the wave images to generate quantitative images depicting tissue stiffness. After tests with tissue-simulating phantom materials and breast cancer specimens, we used the prototypic breast MR elastography technique to image six healthy women and six patients with known breast cancer. Acoustic shear waves were clearly visualized in phantoms, breast cancer specimens, healthy volunteers, and patients with breast cancer. The elastograms of the tumor specimens showed focal areas of high shear stiffness. MR elastograms of healthy volunteers revealed moderately heterogeneous mechanical properties, with the shear stiffness of fibroglandular tissue measuring slightly higher than that of adipose tissue. The elastograms of patients with breast cancer showed focal areas of high shear stiffness corresponding to the locations of the known tumors. The mean shear stiffness of breast carcinoma was 418% higher than the mean value of surrounding breast tissues. The results confirm the hypothesis that the prototypic breast MR elastographic technique can quantitatively depict the elastic properties of breast tissues in vivo and reveal high shear elasticity in known breast tumors. Further research is needed to evaluate the potential applications of MR elastography, such as detecting breast carcinoma and characterizing suspicious breast lesions.

  18. Preliminary results of 45 patients with trigeminal neuralgia treated with radiosurgery compared to hypofractionated stereotactic radiotherapy, using a dedicated linear accelerator.

    PubMed

    Fraioli, Mario Francesco; Strigari, Lidia; Fraioli, Chiara; Lecce, Mario; Lisciani, Damiano

    2012-10-01

    Radiosurgery (RS) and hypofractionated stereotactic radiotherapy (HSRT) were performed in 23 and 22 patients respectively for the treatment of trigeminal neuralgia. RS and HSRT were performed with a dedicated linear accelerator (LINAC): an invasive frame (for RS) or a relocatable stereotactic frame fitted with a thermoplastic mask and bite blocks (HSRT) were used for positioning patients. The RS treatment delivered 40 Gy in a single fraction, or for HSRT, the equivalent radiobiological fractionated dose - a total of 72 Gy in six fractions. The target (the retrogasserian cisternal portion of the trigeminal nerve) was identified by fusion of CT scans with 1-mm-thick T2-weighted MRI, and the radiant dose was delivered by a 10-mm-diameter cylindrical collimator. The results were evaluated using the Barrow Neurological Institute pain scale during follow-up (mean 3.9 years). The 95% isodose was applied to the entire target volume. After RS (23 patients), Class 1 results were observed in 10 patients; Class II in nine, Class IIIa in two, Class IIIb in one, and Class V results in one patient. Facial numbness occurred in two (8.7%) patients, and the trigeminal neuralgia recurred in two patients (8.7%). Following HSRT (22 patients), Class I results were achieved in eight patients, Class II in eight, Class IIIa in four, and Class IIIb in two patients; recurrence occurred in six (27.5%), and there were no complications. Thus, both RS and HSRT provided effective and safe therapy for the treatment of trigeminal neuralgia. Patients who underwent RS experienced better pain relief and a lower recurrence rate, whereas those who underwent HRST had no side effects, and in particular, no facial numbness. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Preliminary results of thoracoscopic Belsey Mark IV antireflux procedure.

    PubMed

    Nguyen, N T; Schauer, P R; Hutson, W; Landreneau, R; Weigel, T; Ferson, P F; Keenan, R J; Luketich, J D

    1998-06-01

    Laparoscopic Nissen fundoplication has replaced open approaches for refractory gastroesophageal reflux disease (GERD) in many major medical centers. Here we report our preliminary results of the Belsey Mark IV antireflux procedure performed by video-assisted thoracoscopy (VATS-Belsey). Fifteen patients underwent VATS-Belsey. The indications for surgery included GERD refractory to medical therapy (n=10), achalasia (n=2), diffuse esophageal spasms (n=1), epiphrenic esophageal diverticulum (n=1), and paraesophageal hernia (n=1). The median operative time was 235 min. There were three conversions to open minithoracotomy (8-10 cm) necessitated by severe adhesions (n=2) and repair of a gastric perforation (n=1). The median hospital stay was 4 days. Postoperative complications included persistent air leaks, requiring discharge with a Heimlich valve in one patient. There were no perioperative deaths. At a median follow-up of 19 months, ten patients (66%) were asymptomatic and were not taking any antacids. One patient who had taken proton pump inhibitors preoperatively required postoperative H2 blockers for mild heartburn. In three patients, recurrent GERD symptoms (mean follow-up 6 months) led to laparoscopic takedown of the Belsey and Nissen fundoplication. One patient with achalasia, who had recurrent dysphagia after 1 year of relief following VATS myotomy and Belsey, underwent esophagectomy. The Belsey Mark IV antireflux procedure is technically feasible by VATS with minimal morbidity. However, our preliminary results suggest that open thoracotomy for Belsey Mark IV should remain the standard operation for GERD with poor esophageal motility when a thoracic approach is desired. We have modified our approach to laparoscopic partial fundoplications (Toupet or Dor) for severe GERD and poor esophageal motility when an abdominal approach is possible.

  20. [Peripheral neuropathies and antiretroviral drugs. Preliminary results].

    PubMed

    Thiam, A; Diagne, M; Ndiaye, Ng; Ngom Gueye, N F; Diakhate, N D; Sow, P S; Ndiaye, I P

    2005-01-01

    In order to appreciate the antiretroviral drugs impact in the HIV positive patients with peripheral neuropathy, a clinical, electrophysiological and neurpathological study of nerve biopsies was performed. A group of 8 HIV seropositive patients with peripheral neuropathy was compared with an other group of 10 HIV seropositive patients treated with multiple antiretroviral drugs. Electrophysiological examination with motor nerve conduction velocity (MNCV) mesure of the median and the sciatic popliteal nerve was followed by nerve biopsy. Nerve fragments carried out the neuropathological technics for morphological examination. Eighteen seropositive HIV patients (16 HIV-1 and 2 HIV-2) were included in this study. Six patients among them had motor and sensitive neuropathy of the four limbs and 2 patients had sensitive neuropathy associated with pyramidal signs. In fine, 1 patient had sensitive neuropathy with distal amyotrophy of the four limbs. Slow MNCV was observed in all the patients and more severe in the lower limbs. Nerve were unexciting in the lower limbs in 2 patients. Nerve biopsy showed severe axonal loss in all the patients treated but one. They associated axonal lesion in 5 cases and myelinated lesions in 2 cases. Two patients non treated had normal nerve biopsy. Axonal loss was mild in 2 cases and very severe in one case associated with non inflammatory demyelinated lesions. we observed more severe and more frequent nerve lesions in treated patients than in no treated patients, as at the clinical, electrophysiological and neuropathological examination. Antiretroviral drugs cause more frequently pain motor and sensitive neuropathies at usual posologies. The occurence of recrudescence of pain peripheral neuropathy under antiretroviral treatment allows to reconsider drugs posologies.

  1. Diagnostics of Sacroiliitis According to ASAS Criteria: A Comparative Evaluation of Conventional Radiographs and MRI in Patients with a Clinical Suspicion of Spondyloarthropathy. Preliminary Results

    PubMed Central

    Sudoł-Szopińska, Iwona; Kwiatkowska, Brygida; Włodkowska-Korytkowska, Monika; Matuszewska, Genowefa; Grochowska, Elżbieta

    2015-01-01

    Summary Background The objective of this study was a comparative evaluation of radiography and MRI in the diagnostics of sacroiliitis in patients with a clinical diagnosis of spondyloartropathy, according to the current ASAS criteria. Material/Methods Sacroiliac joints radiograms and MRI were conducted in 101 consecutive patients, aged 19–71 yrs (mean age: 40.6 yrs). The patients were referred by a senior rheumatologist, with symptoms of the chronic back pain. The sacroiliac joints were assessed on AP radiograms of the pelvis according to the modified New York criteria for ankylosing spondylitis. MRI was performed to look for active and chronic inflammatory lesions. Results Of 14 patients with radiographic sacroiliitis according to modified New York criteria, only 50% had sacroiliitis on MRI. The sensitivity and specificity of conventional radiography were 22% and 94% and of MRI were 71% and 90%. Cohen’s kappa coefficient was κ=0.0187, agreement of radiograms and MRI was 58%. Among 86 patients displaying no sacroiliitis on radiograms, MRI showed sacroiliitis in 34 patients (39.5%). Positive predictive value was 0.429, negative predictive value was 0.605. Conclusions MRI allowed to diagnose sacroiliitis in 39,5 % of patients in preradiographic stage. MRI ruled out the presence of active inflammatory lesions in 60.4% of patients with sacroiliitis on radiograms according to modified New York criteria. PMID:26082819

  2. Determination of ANA specificity using multiplexed fluorescent microsphere immunoassay in patients with ANA positivity at high titres after infliximab treatment: preliminary results.

    PubMed

    Caramaschi, Paola; Ruzzenente, Orazio; Pieropan, Sara; Volpe, Alessandro; Carletto, Antonio; Bambara, Lisa Maria; Biasi, Domenico

    2007-05-01

    To evaluate ANA specificity using the fully automated multiplexed fluorescent microsphere immunoassay in patients affected either by rheumatoid arthritis or ankylosing spondylitis who developed strong positivity for ANA as assessed by indirect immunofluorescent method on HEp-2 cells during infliximab treatment. Three men affected by ankylosing spondylitis and 12 women affected by rheumatoid arthritis who developed ANA positivity at high titres during infliximab treatment underwent the identification of ANA specificity by multiplexed fluorescent microsphere immunoassay; moreover anti-DNA and anti-ENA antibodies were tested by indirect immunofluorescence and ELISA method, respectively. In 4 out of 15 cases, the determination of ANA reactivity by multiplexed fluorescent microsphere immunoassay was also performed on the serum collected before infliximab administration. One patient affected by rheumatoid arthritis showed multiple ANA reactivities against SS-A, SS-B, RNP, Sm, Jo-1 and histones; one patient affected by ankylosing spondylitis resulted positive for the same autoantibodies, except for anti-Sm antibody. Moreover, two patients, one with rheumatoid arthritis and one with ankylosing spondylitis, showed single antibody specificity to SS-B and RNP, respectively. The remaining 11 cases did not show any positivity. Instead, all the patients resulted negative for anti-ENA antibodies by the ELISA method. In the four cases tested for ANA specificity by multiplexed fluorescent microsphere immunoassay before and after infliximab administration no difference was found. The search for anti-DNA antibody always resulted negative by both the traditional immunofluorescent assay and the novel technique. The use of multiplexed fluorescent microsphere immunoassay in patients treated with infliximab with ANA positivity at high titres allowed to find some ANA specificities which were not revealed by ELISA method. Nevertheless, the majority of patients resulted negative in spite of

  3. Improved self-exclusion program: preliminary results.

    PubMed

    Tremblay, Nicole; Boutin, Claude; Ladouceur, Robert

    2008-12-01

    The gambling industry has offered self-exclusion programs for quite a long time. Such measures are designed to limit access to gaming opportunities and provide problem gamblers with the help they need to cease or limit their gambling behaviour. However, few studies have empirically evaluated these programs. This study has three objectives: (1) to observe the participation in an improved self-exclusion program that includes an initial voluntary evaluation, phone support, and a mandatory meeting, (2) to evaluate satisfaction and usefulness of this service as perceived by self-excluders, (3) to measure the preliminary impact of this improved program. One hundred sixteen self-excluders completed a questionnaire about their satisfaction and their perception of the usefulness during the mandatory meeting. Among those participants, 39 attended an initial meeting. Comparisons between data collected at the initial meeting and data taken at the final meeting were made for those 39 participants. Data showed that gamblers chose the improved self-exclusion program 75% of the time; 25% preferred to sign a regular self-exclusion contract. Among those who chose the improved service, 40% wanted an initial voluntary evaluation and 37% of these individuals actually attended that meeting. Seventy percent of gamblers came to the mandatory meeting, which was a required condition to end their self-exclusion. The majority of participants were satisfied with the improved self-exclusion service and perceived it as useful. Major improvements were observed between the final and the initial evaluation on time and money spent, consequences of gambling, DSM-IV score, and psychological distress. The applicability of an improved self-exclusion program is discussed and, as shown in our study, the inclusion of a final mandatory meeting might not be so repulsive for self-excluders. Future research directives are also proposed.

  4. Preliminary Results of the Adoption and Application of the Integrated Comprehensive Care Bundle Care Program When Treating Patients with Chronic Obstructive Pulmonary Disease

    PubMed Central

    Guertin, Jason R.; Bowen, James M.; Gosse, Carolyn; Blackhouse, Gord; O'Reilly, Daria J.; Baltaga, Emanuel; Cox, Gerard; Johnson, Donna; Le Blanc, Brandi; Loncke, Jane; Pugsley, Stewart; Sivakumaran, Ravi; Wheatley, Laura; Smith, Kevin

    2017-01-01

    Background St. Joseph's Health System has implemented an integrated comprehensive care bundle care (ICC) program with the hopes that it would improve patients' care while reducing overall costs. The aim of this analysis was to evaluate the performance of the ICC program within patients admitted with chronic pulmonary obstructive disease (COPD). Methods We conducted a retrospective observational cohort study comparing ICC patients to non-ICC patients admitted to St. Joseph's Healthcare Hamilton for COPD being discharged with support services between June 2012 and March 2015, using administrative data. Confounding adjustment was achieved through the use of propensity score matching. Medical resource utilizations during the initial hospitalization and within the 60 days following discharge were compared using regression models. Results All 76 patients who entered the ICC program (100.0%) were matched 1 : 1 to 76 eligible non-ICC patients (28.4%). Length of stay (6.47 [7.29] versus 9.55 [10.21] days) and resource intensity weights (1.16 [0.80] versus 1.64 [1.69]) were lower in the ICC group within the initial hospitalization but, while favoring the ICC program, healthcare resource use tended not to differ statistically following discharge. Interpretation The ICC program was able to reduce initial medical resource utilization without increasing subsequent medical resource use. PMID:28848370

  5. Economic analysis of amifostine as adjunctive support for patients with advanced head and neck cancer: preliminary results from a randomized phase II clinical trial from Germany.

    PubMed

    Bennett, C L; Lane, D; Stinson, T; Glatzel, M; Buntzel, J

    2001-01-01

    In a randomized phase II trial in Germany, we investigated the clinical and economic impact of amifostine protection against the hematological and oral toxicities of carboplatin administered concurrently with standard fractions of radiotherapy. 28 patients with squamous cell carcinomas of the head and neck received adjunctive or primary radiotherapy (5 days per week with daily fractions of 2 Gy, up to a total dose of 60 Gy) in conjunction with carboplatin (70 mg/m2) on days 1-5 and days 21-26. All patients received radiation encompassing at least 75% of the major salivary glands. Patients were randomized to receive radiation and carboplatin (RCT) alone or RCT preceded by rapid infusion of amifostine (500 mg) on days carboplatin was administered. The 14 patients who received amifostine, in comparison to 14 patients in the control arm, had significantly fewer episodes of grade 3 or 4 thrombocytopenia (p = 0.001), mucositis (p = 0.001), and xerostomia (p = 0.001). The patients receiving amifostine accrued significantly lower supportive care costs for resources related to infection ($241 vs. $1,275, p < 0.01), red blood cell and platelet support ($286 vs. $1,276 p = 0.06) alimentation ($343 vs. $894, p = .01), and hospitalization ($286 vs. $2,429, p < 0.01). Overall, including the costs of amifostine, mean per patient supportive care costs were $4,401 for the amifostine group and $5,873 (p = .02) for the control group. Our results from a randomized phase II trial indicate that selective cytoprotection with amifostine potentially offers clinical and economic benefits in patients with advanced head and neck cancer receiving radiochemotherapy. Additional economic studies alongside randomized phase III trials and from other countries are needed.

  6. High-resolution MR lymphography using ultrasmall superparamagnetic iron oxide (USPIO) in the evaluation of axillary lymph nodes in patients with early stage breast cancer: preliminary results.

    PubMed

    Kimura, Kosei; Tanigawa, Nobuhiko; Matsuki, Mitsuru; Nohara, Takehiro; Iwamoto, Mitsuhiko; Sumiyoshi, Kazuhiro; Tanaka, Satoru; Takahashi, Yuko; Narumi, Yoshifumi

    2010-10-01

    The purpose of this study was to examine the utility of high-resolution magnetic resonance (MR) lymphography using ultrasmall superparamagnetic iron oxide (USPIO) in the evaluation of axillary lymph nodes in patients with early stage breast cancer. Ten women with breast cancer without swollen axillary lymph nodes were enrolled in this study. High-resolution MR lymphography was performed 24 h after administration of USPIO. On the MR examination, a 3-inch surface coil was placed on the sentinel lymph node (SLN) parts as defined by a radioisotope (RI) scintigraphy method, and T2*-weighted (T2*W) and T1-weighted (T1W) images were obtained. Detected nodes were differentiated as normal or diseased nodes by the enhancement patterns. The day after MR examination, SLN biopsy (SNB) was performed. The imaging results were compared to the histopathologic findings. On MR images, the mean number of detectable nodes was 7.9 per patient. Eight patients who histopathologically had no metastatic lymph nodes were diagnosed as nonmetastatic and two patients who had 3- and 6-mm metastatic areas in the node, respectively, were diagnosed as metastatic preoperatively. No side effects were noted. High-resolution MR lymphography using USPIO enabled us to obtain good axillary lymph node evaluation results. These results suggest that this method of imaging may contribute to better preoperative lymph node staging.

  7. Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results

    PubMed Central

    Luigi, Petramala; Chiara, Formicuccia Maria; Laura, Zinnamosca; Cristiano, Marinelli; Giuseppina, Cilenti; Luciano, Colangelo; Giuseppe, Panzironi; Sabrina, Cerci; Susanna, Sciomer; Antonio, Ciardi; Giuseppe, Cavallaro; Giorgio, De Toma; Claudio, Letizia

    2012-01-01

    Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56 ± 6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55 ± 4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55 ± 6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and “non-dipping phenomenon.” Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT. PMID:22719761

  8. Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results.

    PubMed

    Luigi, Petramala; Chiara, Formicuccia Maria; Laura, Zinnamosca; Cristiano, Marinelli; Giuseppina, Cilenti; Luciano, Colangelo; Giuseppe, Panzironi; Sabrina, Cerci; Susanna, Sciomer; Antonio, Ciardi; Giuseppe, Cavallaro; Giorgio, De Toma; Claudio, Letizia

    2012-01-01

    Background. Primary hyperparathyroidism (PHPT) is associated with high cardiovascular morbidity, and the role of calcium and parathyroid hormone is still controversial. Objective. To evaluate the prevalence and outcomes of metabolic syndrome, hypertension, and some cardiovascular alterations in asymptomatic PHPT, and specific changes after successful parathyroidectomy. Material and Methods. We examined 30 newly diagnosed PHPT patients (8 males, 22 females; mean age 56 ± 6 yrs), 30 patients with essential hypertension (EH) (9 males, 21 females; mean age 55 ± 4), and 30 normal subjects (NS) (9 males, 21 females: mean age 55 ± 6). All groups underwent evaluation with ambulatory monitoring blood pressure, echocardiography, and color-Doppler artery ultrasonography and were successively revaluated after one year from parathyroidectomy. Results. PHPT patients presented a higher prevalence of metabolic syndrome (38%) with respect to EH (28%). Prevalence of hypertension in PHPT was 81%, and 57% presented altered circadian rhythm of blood pressure, with respect to EH (35%) and NS (15%). PHPT showed an important myocardial and vascular remodelling. During follow-up in PHPT patients, we found significant reduction of prevalence of metabolic syndrome, blood pressure, and "non-dipping phenomenon." Conclusions. Cardiovascular and metabolic alterations should be considered as added parameters in evaluation of patients with asymptomatic PHPT.

  9. High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis

    PubMed Central

    Cai, Xu-wei; Fu, Xiao-long; Li, Yuan; Zhou, Xiao-yan; Wu, Xiang-hua; Hu, Xi-chun; Fan, Min; Xiang, Jia-qing; Zhang, Ya-wei; Chen, Hai-quan; Perez, Rolando; Jiang, Guo-liang; Zhao, Kuai-le

    2015-01-01

    The epidermal growth factor receptor (EGFR) is widely overexpressed in esophageal squamous cell carcinoma (ESCC) and it results is associated with a poor prognosis. Identifying the subgroup of ESCC patients who are sensitive to EGFR-targeted therapy is a key point to facilitate its medical use. We retrospectively analyzed 32 ESCC patients treated with the combination of nimotuzumab (h-R3) and radiotherapy (RT) or chemoradiotherapy (CRT). Expression of EGFR and phosphorylated proteins associated with EGFR signaling pathway, i.e. p-Akt and p-Erk, were assessed with immunohistochemistry (IHC) for all patients. Correlations between these proteins' expression levels and overall survival (OS) were assessed. High expression of EGFR, p-Akt and p-Erk was detected in 53.1% (17/32), 54.8% (17/31) and 59.4% (19/32) of tumors respectively. No significant differences in OS were found between high EGFR, p-Akt and p-Erk expression groups and their respective counterparts. Of note, significantly better overall survival was observed in patients with coexistence of high EGFR expression and low p-Akt expression (p = 0.030). Our data allowed us to put forward a hypothesis that high EGFR and low p-Akt expression may predict a clinical benefit of EGFR antagonists such as nimotuzumab combined with RT or CRT. This can be discussed in the terms of oncogene addiction and synthetic lethality concepts. This hypothesis can be further tested in larger groups of patients. PMID:26124180

  10. High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis.

    PubMed

    Wang, Chun-yu; Deng, Jia-ying; Cai, Xu-wei; Fu, Xiao-long; Li, Yuan; Zhou, Xiao-yan; Wu, Xiang-hua; Hu, Xi-chun; Fan, Min; Xiang, Jia-qing; Zhang, Ya-wei; Chen, Hai-quan; Perez, Rolando; Jiang, Guo-liang; Zhao, Kuai-le

    2015-07-30

    The epidermal growth factor receptor (EGFR) is widely overexpressed in esophageal squamous cell carcinoma (ESCC) and it results is associated with a poor prognosis. Identifying the subgroup of ESCC patients who are sensitive to EGFR-targeted therapy is a key point to facilitate its medical use.We retrospectively analyzed 32 ESCC patients treated with the combination of nimotuzumab (h-R3) and radiotherapy (RT) or chemoradiotherapy (CRT). Expression of EGFR and phosphorylated proteins associated with EGFR signaling pathway, i.e. p-Akt and p-Erk, were assessed with immunohistochemistry (IHC) for all patients. Correlations between these proteins' expression levels and overall survival (OS) were assessed.High expression of EGFR, p-Akt and p-Erk was detected in 53.1% (17/32), 54.8% (17/31) and 59.4% (19/32) of tumors respectively. No significant differences in OS were found between high EGFR, p-Akt and p-Erk expression groups and their respective counterparts. Of note, significantly better overall survival was observed in patients with coexistence of high EGFR expression and low p-Akt expression (p = 0.030).Our data allowed us to put forward a hypothesis that high EGFR and low p-Akt expression may predict a clinical benefit of EGFR antagonists such as nimotuzumab combined with RT or CRT. This can be discussed in the terms of oncogene addiction and synthetic lethality concepts. This hypothesis can be further tested in larger groups of patients.

  11. Earth Radiation Budget Experiment - Preliminary seasonal results

    NASA Technical Reports Server (NTRS)

    Barkstrom, Bruce R.; Harrison, Edwin F.; Lee, Robert B., III

    1990-01-01

    Data from the Earth Radiation Budget Satellite (ERBS) and from the operational NOAA-9 satellite being placed in the archive of the earth Radiation Budget Experiment (ERBE) are discussed. The results of the ERBE data validation effort are reviewed along with ERBE solar constant observations and earth-viewing results. The latter include monthly average results for July 1985, annual average clear-sky fluxes, and annual average, zonal, and global results.

  12. MR elastography of the liver: preliminary results.

    PubMed

    Rouvière, Olivier; Yin, Meng; Dresner, M Alex; Rossman, Phillip J; Burgart, Lawrence J; Fidler, Jeff L; Ehman, Richard L

    2006-08-01

    To develop a method for measuring liver stiffness with magnetic resonance (MR) elastography and to prospectively test this technique in healthy volunteers and patients with liver fibrosis. This HIPAA-compliant study was approved by an institutional review board, and informed consent was obtained from each subject. First, to determine the feasibility of applying shear waves to the liver, a pneumatic acoustic wave generator was developed and tested by using a tissue-simulating gel phantom with ribs on one side and without ribs on the other. The effect of interposed ribs on stiffness measurements was tested. Then, liver stiffness was measured with MR elastography in 12 healthy volunteers (eight men, four women; mean age, 26.7 years; age range, 19-39 years) by using the subcostal approach and the transcostal approach and in 12 patients with chronic liver disease (six men, six women; mean age, 50.5 years; age range, 36-60 years) by using the transcostal approach. Various statistical analyses were performed to assess all measurements. Ex vivo, interposed ribs reduced shear wave amplitude but did not hinder stiffness measurements. In volunteers, the transcostal approach surprisingly yielded better shear waves in the liver than did the subcostal approach. The mean liver shear stiffness was significantly lower in volunteers (mean, 2.0 kPa +/- 0.3 [standard deviation]) than it was in patients with liver fibrosis (mean, 5.6 kPa +/- 5.0; median, 3.7 kPa; range, 2.7-19.2 kPa; P < .001). MR elastography of the liver is feasible and shows promise as a quantitative method for noninvasive assessment of liver fibrosis. RSNA, 2006

  13. Preliminary Results from the Lunar Prospector Alpha Particle Spectrometer

    NASA Astrophysics Data System (ADS)

    Lawson, S. L.; Feldman, W. C.; Moore, K. R.; Lawrence, D. J.; Maurice, S.; Belian, R. D.; Binder, A. B.

    2001-03-01

    Data measured using the Lunar Prospector Alpha Particle Spectrometer were surveyed to search for surface deposits of polonium-210. Preliminary results show that a marginal, yet statistically-significant signal was indeed detected on the lunar front side.

  14. Results from a preliminary review of scientific evidence for appropriateness of preparations, dosage forms and other product design elements for older adult patients.

    PubMed

    Messina, Rossella; Becker, Robert; van Riet-Nales, Diana A; Stegemann, Sven

    2015-01-30

    The aging population and the growing multimorbidity of the major patient population as well as the advanced (pharmaco)therapeutic treatment options are increasing the complexity of independent drug therapy management and administration. The increased complexity may have an impact on drug adherence (including any need for patients initiated coping strategies), and consequently on the safety and efficacy of the medicine. To overcome adherence issues caused by the design of the medicine, it is crucial that developers consider the age appropriateness of the medicine (route of administration, dosage form, excipients in the composition, frequency of dosing) in meeting patients' needs to manage their therapy without the support of a care giver. In order to understand the scientific evidence on such age appropriately designed medicines for use by older adults, a literature search was performed in the Medline database (all languages included). The search produced 34 publications that met the inclusion and exclusion criteria for the patient population of 65 years an older. An in-depth analysis of the included publications with respect to the methodological quality (study design, data collection, endpoints chosen) and results showed that none of these publications had adequately investigated the age appropriateness of the medicine for use by older adults. The authors consider that the knowledge gap in this area requires attention of all stakeholders in the healthcare community. Copyright © 2014. Published by Elsevier B.V.

  15. Preliminary results of steel containment vessel model test

    SciTech Connect

    Luk, V.K.; Hessheimer, M.F.; Matsumoto, T.; Komine, K.; Arai, S.; Costello, J.F.

    1998-04-01

    A high pressure test of a mixed-scaled model (1:10 in geometry and 1:4 in shell thickness) of a steel containment vessel (SCV), representing an improved boiling water reactor (BWR) Mark II containment, was conducted on December 11--12, 1996 at Sandia National Laboratories. This paper describes the preliminary results of the high pressure test. In addition, the preliminary post-test measurement data and the preliminary comparison of test data with pretest analysis predictions are also presented.

  16. Electroencephalographic theta activity and cognition in schizophrenia: preliminary results.

    PubMed

    Wichniak, Adam; Okruszek, Łukasz; Linke, Magdalena; Jarkiewicz, Michał; Jędrasik-Styła, Małgorzata; Ciołkiewicz, Agnieszka; Wierzbicka, Aleksandra; Jernajczyk, Wojciech; Jarema, Marek

    2015-04-01

    MATRICS Consensus Cognitive Battery (MCCB) is a contemporary standard for assessment of cognitive functions in schizophrenia. The aim of the study was to examine the association between electroencephalographic spectral power and a wide range of cognitive functions measured with MCCB. Thirty-nine patients with schizophrenia (27 male, mean age 28.2 ± 5.2 years) underwent EEG recordings and were assessed with MCCB. The EEG recordings were visually inspected and manually cleaned from artifacts and subjected to spectral analysis with EEGlab. Absolute and relative power as percentage of total spectral power were computed for frequency ranges from 0.5 to 30 Hz. To compare spectral power in patients with various cognitive functioning, patients from best and worst MCCB quartiles were selected. Superior cognitive performance was associated with less power of theta waves. Six MCCB cognitive tests showed significant correlations with absolute theta power and three tests with relative theta power. The correlation coefficients between MCCB composite score and theta power were rp = -0.45 for absolute and rp = -0.36 for relative values. Increased theta power was linked especially to memory deficits. These preliminary results suggest that electroencephalographic resting state theta power is an indicator of cognitive deficit in patients with schizophrenia.

  17. [Immunology in the medical practice.XXXII. Transplantation of autologous hematopoietic stem cells for treatment of refractory auto-immune diseases; preliminary favorable results with 35 patients].

    PubMed

    Vlieger, A M; van den Hoogen, F H; Brinkman, D M; van Laar, J M; Schipperus, M; Kruize, A A; Wulffraat, N M

    2000-08-12

    The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.

  18. [Ultrasonic welding of bones. Preliminary results].

    PubMed

    Brug, E; Braunsteiner, E; von Gemmern, C

    1976-10-01

    Experiments with ultrasonic applied welding, a method first developed in the USSR are reported. In standardized isolated bone preparations stability values could be obtained of 10% [and in one case of 40% (!)] of the stability of the nonfractured bone. With these values the requirements of the method of osteosynthesis are met. Results of in vivo experiments are expected.

  19. Preliminary Youth Risk Behavior Survey Results--1993.

    ERIC Educational Resources Information Center

    Johnson, Joyce, Comp.

    This paper provides the results of a 1993 survey of 2,684 New Hampshire high school students in regard to risk taking, personal violence, suicide, tobacco use, alcohol abuse, drug abuse, acquired immune deficiency syndrome (AIDS) education, sexual activity, nutrition, and exercise. It found that in the preceding 30 days, 10.8 percent of students…

  20. Preliminary Silver-hydrogen Cell Test Results

    NASA Technical Reports Server (NTRS)

    Lurie, C.

    1984-01-01

    Silver-hydrogen cells were tested. The objective of the test was to estimate useful life by operation at accelerated, simulated geosynchronous orbit conditions. Ten simulated seasons were run and are summarized. The results to-date reflect stable, trouble-free performance and indicate that the silver-hydrogen couple shows promise as a lightweight alternative to the nickel systems.

  1. Pioneer 11 meteoroid detection experiment - Preliminary results

    NASA Technical Reports Server (NTRS)

    Humes, D. H.; Alvarez, J. M.; Kinard, W. H.; Oneal, R. L.

    1975-01-01

    The concentration of meteoroids of mass about 0.01 microgram in interplanetary space, in the asteroid belt, and near Jupiter has been measured. The data confirm the Pioneer 10 observation that the asteroid belt is not highly populated with small meteoroids, suggest that the high concentration of small particles around Jupiter is the result of gravitational focusing, and provide an indication of the mass distribution of meteoroids in interplanetary space.

  2. Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results

    PubMed Central

    Ghanaati, Shahram; Barbeck, Mike; Lorenz, Jonas; Stuebinger, Stefan; Seitz, Oliver; Landes, Constantin; Kovács, Adorján F.; Kirkpatrick, Charles J.; Sader, Robert A.

    2013-01-01

    Background: The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity. Materials and Methods: Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement. Results: Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group. Conclusions: Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer. PMID:24205471

  3. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study

    PubMed Central

    Neukam, Karin; Espinosa, Nuria; Merino, Dolores; Rivero-Juárez, Antonio; Carrero, Ana; José Ríos, María; Ruiz-Morales, Josefa; Gómez-Berrocal, Ana; Téllez, Francisco; Díaz-Menéndez, Marta; Collado, Antonio; Pérez-Camacho, Inés; Delgado-Fernández, Marcial; Vera-Méndez, Francisco; Pineda, Juan A

    2014-01-01

    Introduction Although hepatotoxicity related to antiretroviral treatment (ART) has become less frequent, hepatotoxic events, such as transaminase elevations (TE), are still a matter of concern. RPV/FTC/TDF (EPA) is a new single tablet regimen which is widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV-coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low [1]. The aim of this ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE) during the first 48 weeks of EPA-based therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials. Patients and Methods This is a retrospective analysis of HIV/HCV-coinfected subjects who started EPA at the infectious diseases units of 14 centres throughout Spain, included as cases. Subjects who started an ART different to EPA during the study period at the same hospitals were selected as controls. The primary outcome variables were grade 3 or 4 TE and grade 4 TBE. Results Of the 191 patients included, 31 (16.2%) subjects were naïve to ART. Eighty-seven individuals started EPA and the remaining ones were controls. The most common NRTI backbone among the controls was TDF/FTC [59 (56.7%) patients] followed by NRTI-sparing regimens [24 (23.1%) individuals] and ABC/3TC [17 (16.3%) subjects]. Among controls, 67 (64.4%) started a ritonavir-boosted protease inhibitor, mainly DRV/r [41 (39.4%) patients] followed by ATV/r [16 (15.4%) subjects]. EFV, ETV and RAL were started in 16 (15.4%), 12 (11.5%) and 13 (12.5%) subjects, respectively. The median (Q1–Q3) follow-up was 5.79 (3.65–8.61) months for the cases and 11.44 (5.8–12.88) months for the controls. TE was observed in two (2.3%) cases versus five (4.8%) controls (p=0.358), accounting for a density of incidence of 4.32/100 person-years versus 5.51/100 person-years [incidence rate difference (95

  4. Medical Radioisotope Data Survey: 2002 Preliminary Results

    SciTech Connect

    Siciliano, Edward R.

    2004-06-23

    A limited, but accurate amount of detailed information about the radioactive isotopes used in the U.S. for medical procedures was collected from a local hospital and from a recent report on the U.S. Radiopharmaceutical Markets. These data included the total number of procedures, the specific types of procedures, the specific radioisotopes used in these procedures, and the dosage administered per procedure. The information from these sources was compiled, assessed, pruned, and then merged into a single, comprehensive and consistent set of results presented in this report. (PIET-43471-TM-197)

  5. [Hearing screening of newborns. Preliminary results].

    PubMed

    Courtmans, I; Mancilla, V; Ligny, C; Belhadi, B; Damis, E; Mahillon, P

    2005-02-01

    Since 1976, an hearing screening is organized at the Clinic Edith Cavell. The testing was based on a behavioral technique of Veit-Bizaguet and, since 2001, the otoacoustic emissions are realised. The National Institutes of Health (1993) recommends universal newborn hearing screening of all newborns before 3 months of age and identification and treatment before 6 months of age. Indeed, detection of hearing loss and early intervention allow a better access to the language and consequently an easier schooling and social integration. This article shows the results of the screening from february at the end of December 2002. These data are compared with those of the literature.

  6. CUATENEO Network: preliminary results after first reobservation

    NASA Astrophysics Data System (ADS)

    Garate, J.; Martin Davila, J.; Suriñach, E.; Berrocoso, M.; Perez Peña, A.; Talaya, J.

    2003-04-01

    Cuateneo GPS network was established in 1997 as a result of a collaboration between different specialists in Earth Sciences from the University of Barcelona and the Institute Cartographic of Catalonia. It was set up in the South Eastern part of the Iberian Peninsula, at the Eastern Betics. Such area is interesting from a tectonic point of view despite its activity drives to moderate deformation rates, but the values of this rates are locally high. So the network was designed to control the most active fractures of the area bearing in mind the historical and recent seismic information and the deformation of recent sediments. A first GPS episodic campaign was performed in April 1997, and a second one has been made in September-October 2002. This one has been done as a collaboration between the San Fernando Observatory and the University of Barcelona, with the support of students from the University of Cadiz. The goal of this presentation is to show how the work has been carried out, and the results we got from the observation, although of course, more campaigns should be made in order to get a complete picture of the tectonic behaviour of the area.

  7. Modelling Extortion Racket Systems: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Nardin, Luis G.; Andrighetto, Giulia; Székely, Áron; Conte, Rosaria

    Mafias are highly powerful and deeply entrenched organised criminal groups that cause both economic and social damage. Overcoming, or at least limiting, their harmful effects is a societally beneficial objective, which renders its dynamics understanding an objective of both scientific and political interests. We propose an agent-based simulation model aimed at understanding how independent and combined effects of legal and social norm-based processes help to counter mafias. Our results show that legal processes are effective in directly countering mafias by reducing their activities and changing the behaviour of the rest of population, yet they are not able to change people's mind-set that renders the change fragile. When combined with social norm-based processes, however, people's mind-set shifts towards a culture of legality rendering the observed behaviour resilient to change.

  8. Emetophobia: preliminary results of an internet survey.

    PubMed

    Lipsitz, J D; Fyer, A J; Paterniti, A; Klein, D F

    2001-01-01

    Through electronic mail, we surveyed members of an internet support group for emetophobia (fear of vomiting). Respondents were 50 women and 6 men with a mean age of 31 years. Results suggest that, for this sample, emetophobia is a disorder of early onset and chronic course, with highly persistent and intrusive symptoms. Emetophobia is implicated in social, home-marital, and occupational impairment and it causes significant constriction of leisure activities. Nearly half of women avoided or delayed becoming pregnant. About three quarters of respondents have eating rituals or significantly limit the foods they eat. Respondents describe other problems such as depression, panic attacks, social anxiety, compulsions, and frequent history of childhood separation anxiety. Copyright 2001 Wiley-Liss, Inc.

  9. Is whole gland salvage cryotherapy effective as palliative treatment of haematuria in patients with locally advanced prostate cancer? Results of a preliminary case series

    PubMed Central

    Mucciardi, Giuseppe; Galì, Alessandro; Pappalardo, Rosa; Lembo, Francesco; Anastasi, Giuseppina; Butticè, Salvatore; Ascenti, Giorgio; Lugnani, Franco

    2015-01-01

    Objectives: Locally advanced prostate cancer may cause several complications such as haematuria, bladder outlet obstruction, and renal failure due to the ureteral obstruction. Various treatments have been suggested, including radiotherapy, antifibrinolytics, bladder irrigation with alum solution, transurethral surgery and angioembolization, none of which have proven effectiveness. In the last years cryoablation has become a valid therapeutic option for prostate cancer. In our experience we used this ‘new’ technique as haemostatic therapy. Methods: We selected four patients with gross haematuria affected by locally advanced hormone refractory prostate cancer, who had already been treated with primary radiotherapy. We used third-generation cryotherapy: under ultrasonographic guidance, we inserted six cryoprobes, two in each of the vascular pedicles reaching at least −60°C, and three thermometers. We then induced two freeze–thaw cycles. Results: After the operation the haematuria stopped in all patients and at 9-month follow up we observed a mean of four red cells (range three to five) in the urinary sediment with no evidence of bacteriuria. Prostate volume, prostate-specific antigen and postmicturition residue were significantly reduced. Qmax improved significantly too. Conclusion: Our experience has given us good results with minimal intra- and postoperative complications. We think that haemostatic cryotherapy as a palliative approach for locally advanced prostate cancer could represent a valid treatment option and more consideration could be given to its use. PMID:26425138

  10. Laser treatment of stretch marks: preliminary results

    NASA Astrophysics Data System (ADS)

    Longo, Leonardo; Piccinetti, A. L.; Monache, G. D.; Botta, G.; Mancini, S.

    2000-06-01

    The best treatment of these stretch mark is still unknown. Some authors proposed the treatment with flash-lamp-pumped dye laser 585 nm, with fluence over 8 J/cm2. Reviewing our experiences on no-surgical effects of lasers in the various phases of the wound healing, including the re- epithelization, we would like to apply the no-surgical laser therapy treating the stretch marks of breast, abdomen and lumbo-sacral region. The goal is to inhibit the fibrous tissue metabolism, encouraging the destruction of the collagen fibers with inflammatory mechanism, and increasing the reconstitution of the superficial dermis layers. We treated five cases of stretch marks in women 22-35 years old, since May 1999, with a cycle of applications of double lasers, 511 and 577 nm, with energy of 20 Joule for spot, respecting the maximum thermal relaxation times of the skin. We waited two weeks interval between the applications. Results obtained after five applications are very positive, and we are encouraged to continue this experimentation.

  11. ALMA band 2 optics: Preliminary results

    NASA Astrophysics Data System (ADS)

    Srikanth, Sivasankaran; Gonzalez, Alvaro

    2015-05-01

    The National Radio Astronomy Observatory is currently developing the ALMA Band 2 cartridge, to be completed by mid-2016. The receiver will cover the 67-90 GHz band, with dual linear polarization. An orthomode transducer (OMT) based on turnstile junction has been developed and measured. The measured input return loss is better than 20dB. The optics comprises of a linear taper corrugated horn and a bi-hyperbolic lens that matches the waist of the horn to that of the telescope. The lens mounts on the 300K plate and serves as the vacuum barrier for the cryostat. The window for band 2 is offset from the center of the cryostat by 255mm, which results in a feed/ lens tilt of 2.48° to the cryostat axis. The feed is cooled to 15K, while the lens is at 300K. The minimum distance between the lens and the feed aperture is 83 mm and the maximum size of the lens is 92mm.

  12. Ultrasonic vibration dectection with wavelets: preliminary results.

    PubMed

    Plett, Melani; Beach, Kirk W

    2005-03-01

    Several arterial disorders are known to cause systolic audio vibrations in tissue: they include stenoses, vasospasm, aneurysms, bleeds and arteriovenous fistulas. High-amplitude vibrations can be discovered with conventional Doppler ultrasound (US) instruments; however, differentiating brief, low-amplitude vibrations from other nonstationary echo sources is difficult. Further, characterizing the frequency and amplitude of vibrations is not feasible with conventional Doppler US. The automated detection and estimation of both the frequency and amplitude of vibrations with durations less than 100 ms and amplitudes of a micrometer or less have remained a signal-processing challenge. These vibrations may be associated with both nonstationary colored noise and strong low-frequency clutter. The normalized continuous Morlet wavelet power-spectrum analysis of quadrature Doppler echoes, followed by a binary hypothesis test for noise, results in simulated detection rates above 99.9%, with 0.1% false alarms for signal-on signal-to-noise ratios (SNRs) as low as one. Two clinical examples are included.

  13. Preliminary Results of Solid Gas Generator Micropropulsion

    NASA Technical Reports Server (NTRS)

    deGroot, Wilhelmus A.; Reed, Brian D.; Brenizer, Marshall

    1999-01-01

    A decomposing solid thruster concept, which creates a more benign thermal and chemical environment than solid propellant combustion, while maintaining, performance similar to solid combustion, is described. A Micro-Electro-Mechanical (MEMS) thruster concept with diode laser and fiber-optic initiation is proposed, and thruster components fabricated with MEMS technology are presented. A high nitrogen content solid gas generator compound is evaluated and tested in a conventional axisymmetric thrust chamber with nozzle throat area ratio of 100. Results show incomplete decomposition of this compound in both low pressure (1 kPa) and high pressure (1 MPa) environments, with decomposition of up to 80% of the original mass. Chamber pressures of 1.1 MPa were obtained, with maximum calculated thrust of approximately 2.7 N. Resistively heated wires and resistively heated walls were used to initiate decomposition. Initiation tests using available lasers were unsuccessful, but infrared spectra of the compound show that the laser initiation tests used inappropriate wavelengths for optimal propellant absorption. Optimal wavelengths for laser ignition were identified. Data presented are from tests currently in progress. Alternative solid gas generator compounds are being evaluated for future tests.

  14. HST observations of Chiron: preliminary results

    NASA Astrophysics Data System (ADS)

    BENEDETTI Rossi, Gustavo; Sicardy, Bruno; Buie, Marc W.; Braga-Ribas, Felipe; Ortiz, Jose-Luis; Duffard, Rene; camargo, julio; Vieira-Martins, Roberto; Gratadour, Damien; Dumas, Christophe

    2016-10-01

    Chiron is a Centaur object, with a radius of approximately 110km. It is orbiting between Saturn and Uranus, and may be a Transneptunian Object (TNO) that has been recently (less than 10 My) scattered by gravitational perturbations from Uranus, just like its "twin brother" Chariklo. On June 3rd, 2013, a stellar occultation by Chariklo of a R=12.4 magnitude star was observed from seven sites in South America, which led to the detection of a total of twelve secondary events, revealing the presence of two narrow and dense rings (see more details at Braga-Ribas F. et al., Nature, 2014).Up to now, planetary rings have been detected exclusively around the four giant planets of our Solar System and Chariklo. In spite of hundreds of occultations by asteroids and several space missions, no other small bodies have shown the presence of rings. However, two recent papers (Ruprecht et al. 2015 and Ortiz et. al 2015) report secondary events from stellar occultations by Chiron that have been interpreted either as a dust shell or a ring system. Using the Hubble Space Telescope we obtained direct images of Chiron surroundings to search for rings, jets and/or small satellites. First results will be presented.

  15. Computerized Script Training for Aphasia: Preliminary Results

    PubMed Central

    Cherney, Leora R.; Halper, Anita S.; Holland, Audrey L.; Cole, Ron

    2009-01-01

    Purpose This article describes computer software that was developed specifically for training conversational scripts and illustrates its use with three individuals with aphasia. Methods Three participants with chronic aphasia (Broca’s, Wernicke’s and anomic) were assessed before and after nine weeks of a computer script training program. For each participant, three individualized scripts were developed, recorded on the software, and practiced sequentially at home. Weekly meetings with the speech-language pathologist occurred to monitor practice and assess progress. Baseline and post-treatment scripts were audio-taped, transcribed, and compared to the target scripts for content, grammatical productivity and rate of production of script-related words. Interviews with the person with aphasia and their significant other were conducted at the conclusion of treatment. Results All measures (content, grammatical productivity and rate of production of script-related words) improved for each participant on every script. Two participants gained more than five points on the Aphasia Quotient of the Western Aphasia Battery. Five positive themes were consistently identified from the exit interviews - increased verbal communication, improvements in other modalities and situations, communication changes noticed by others, increased confidence, and satisfaction with the software. Conclusion Computer-based script training potentially may be an effective intervention for persons with chronic aphasia. PMID:18230811

  16. Plantar Pressure Changes and Correlating Risk Factors in Chinese Patients with Type 2 Diabetes: Preliminary 2-year Results of a Prospective Study

    PubMed Central

    Qiu, Xuan; Tian, De-Hu; Han, Chang-Ling; Chen, Wei; Wang, Zhan-Jian; Mu, Zhen-Yun; Liu, Kuan-Zhi

    2015-01-01

    Background: Plantar pressure serves as a key factor for predicting ulceration in the feet of diabetes patients. We designed this study to analyze plantar pressure changes and correlating risk factors in Chinese patients with type 2 diabetes. Methods: We recruited 65 patients with type 2 diabetes. They were invited to participate in the second wave 2 years later. The patients completed identical examinations at the baseline point and 2 years later. We obtained maximum force, maximum pressure, impulse, pressure-time integral, and loading rate values from 10 foot regions. We collected data on six history-based variables, six anthropometric variables, and four metabolic variables of the patients. Results: Over the course of the study, significant plantar pressure increases in some forefoot portions were identified (P < 0.05), especially in the second to forth metatarsal heads. Decreases in heel impulse and pressure-time integral levels were also found (P < 0.05). Plantar pressure parameters increased with body mass index (BMI) levels. Hemoglobin A1c (HbA1c) changes were positively correlated with maximum force (β = 0.364, P = 0.001) and maximum pressure (β = 0.366, P = 0.002) changes in the first metatarsal head. Cholesterol changes were positively correlated with impulse changes in the lateral portion of the heel (β = 0.179, P = 0.072) and pressure-time integral changes in the second metatarsal head (β = 0.236, P = 0.020). Ankle-brachial index (ABI) changes were positively correlated with maximum force changes in the first metatarsal head (β = 0.137, P = 0.048). Neuropathy symptom score (NSS) and common peroneal nerve sensory nerve conduction velocity (SCV) changes were positively correlated with some plantar pressure changes. In addition, plantar pressure changes had a correlation with the appearance of infections, blisters (β = 0.244, P = 0.014), and calluses over the course of the study. Conclusions: We should pay attention to the BMI, HbA1c, cholesterol, ABI

  17. A Phase II Study of Bevacizumab in Combination With Definitive Radiotherapy and Cisplatin Chemotherapy in Untreated Patients With Locally Advanced Cervical Carcinoma: Preliminary Results of RTOG 0417

    SciTech Connect

    Schefter, Tracey E.; Winter, Kathryn; Kwon, Janice S.; Stuhr, Kelly; Balaraj, Khalid; Yaremko, Brian P.; Small, William; Gaffney, David K.

    2012-07-15

    Purpose: Concurrent cisplatin-based chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer. RTOG 0417 was a Phase II study exploring the safety and efficacy of the addition of bevacizumab to standard CRT. Methods and Materials: Eligible patients with bulky tumors (Stage IB-IIIB) were treated with once-weekly cisplatin (40 mg/m{sup 2}) chemotherapy and standard pelvic radiotherapy and brachytherapy. Bevacizumab was administered at 10 mg/kg intravenously every 2 weeks for three cycles. Treatment-related serious adverse event (SAE) and other adverse event (AE) rates within the first 90 days from treatment start were determined. Treatment-related SAEs were defined as any Grade {>=}4 vaginal bleeding or thrombotic event or Grade {>=}3 arterial event, gastrointestinal (GI) bleeding, or bowel/bladder perforation, or any Grade 5 treatment-related death. Treatment-related AEs included all SAEs and Grade 3 or 4 GI toxicity persisting for >2 weeks despite medical intervention, Grade 4 neutropenia or leukopenia persisting for >7 days, febrile neutropenia, Grade 3 or 4 other hematologic toxicity, and Grade 3 or 4 GI, renal, cardiac, pulmonary, hepatic, or neurologic AEs. All AEs were scored using the National Cancer Institute Common Terminology Criteria (CTCAE) v 3.0 (MedDRA version 6.0). Results: A total of 60 patients from 28 institutions were enrolled between 2006 and 2009, and of these, 49 patients were evaluable. The median follow-up was 12.4 months (range, 4.6-31.4 months).The median age was 45 years (range, 22-80 years). Most patients had FIGO Stage IIB (63%) and were of Zubrod performance status of 0 (67%). 80% of cases were squamous. There were no treatment-related SAEs. There were 15 (31%) protocol-specified treatment-related AEs within 90 days of treatment start; the most common were hematologic (12/15; 80%). 18 (37%) occurred during treatment or follow-up at any time. 37 of the 49 patients (76%) had cisplatin and bevacizumab

  18. Prognostic value of quantitative cytometry in a series of 415 T1T2/N0N1/M0 breast cancer patients--preliminary results.

    PubMed

    Bolla, M; Seigneurin, D; Winckel, P; Marron-Charrière, J; Panh, M H; Pasquier, D; Ch-edin, M; Payan, R; Merlin, F; Colonna, M

    1996-09-01

    Identifying prognostic markers in local regional breast carcinomas remains an important challenge today. DNA content obtained by flow cytometry, has been found to be of prognostic value; results with other methods remain less clear. This report describes DNA image cytometry patterns which are assessed with respect to disease-free survival. From June 1982 to December 1992, 415 patients under 75 years of age, without any previous or synchronous carcinoma, suffering from an invasive breast cancer classified as T1 (52.8%), T2 (47.2%), N0 (65.1%) N1 (34.9%), MO according to clinical TNM staging, were enrolled in this study. The median age was 53 (28-75) and 58.8% of the patients were premenopausal; 85.3% underwent a breast conservative procedure and 14.7% a modified radical mastectomy followed by postoperative irradiation. Histological axillary lymph node status, Scarff-Bloom grade and/or cytological grade and, oestrogen receptor content were used in decision-making for adjuvant treatment: hormonotherapy (48%) or chemotherapy (18.8%). Imprints were taken from the macroscopically visible lesion at the time of surgery, and a Feulgen staining was carried out on air dried smears to be analysed using the Samba 200 cell image processor (Alcatel TITN, France). Five parameters were systematically assessed: proliferation index; DNA histogram, integrated optical density, DNA malignancy grade, ploidy balance. With a median follow-up of 36 months (0-105), proliferation index (P = 0.0008), DNA histogram (P = 0.0017), integrated optical density (IOD) (P = 0.018) and DNA malignancy grade (P = 0.017) had a significant prognostic value on disease-free survival estimated by the Kaplan-Meier method. When these parameters were included in a Cox proportional regression hazards model, PR (P = 0.01), Scarff-Bloom histological grading (P = 0.02), axillary clearance (P = 0.04) were significant; however, in the same model, taking into account the axillary lymph node histological status, IOD was

  19. Bahamas Optical Turbulence Exercise (BOTEX): preliminary results

    NASA Astrophysics Data System (ADS)

    Hou, Weilin; Jorosz, Ewa; Dalgleish, Fraser; Nootz, Gero; Woods, Sarah; Weidemann, Alan D.; Goode, Wesley; Vuorenkoski, Anni; Metzger, B.; Ramos, B.

    2012-06-01

    patterns are examined, using high speed camera recordings (300 to 1200 fps), in association with measured turbulence structures. Initial results confirmed our hypothesis that turbulence impacted optical transmissions. They also showed that more research will be needed to better quantify and mitigate such effects, especially for the U.S. Navy's next generation EO systems, including active imaging, lidar and optical communications.

  20. Preliminary Results of Bisphosphonate ISS Flight Experiment

    NASA Technical Reports Server (NTRS)

    LeBlanc, Adrian; Jones, Jeff; Shapiro, Jay; Lang, Tom; Shackelford, Linda C.; Smith, Scott M.; Evans, Harlan J.; Spector, Elisabeth R.; Sibonga, Jean; Matsumoti, Toshio; Nakamura, Toshitaka; Kohri, Kenjiro; Ohshima, Hiroshi

    2010-01-01

    Bone loss has been recognized as a potential problem from the beginning of human spaceflight. With the spaceflight missions lasting 6 months to potentially 3 years or longer this issue has assumed increased significance. Detailed measurements from the Mir and ISS long duration missions have documented losses in bone mineral density (BMD) from the total skeleton and critical sub-regions. The most important losses are from the femoral hip averaging about -1.6%/mo integral to -2.3%/mo trabecular BMD. Importantly these studies have documented the wide range in individual response from -0.5 to -5%/mo in BMD. Given the small size of any expedition crew, the wide range of responses has to be considered in the implementation of any countermeasure. Assuming that it is unlikely that the susceptibility for bone loss in any given crewmember will be known, a suite of bone loss countermeasures will likely be needed to insure protection of all crewmembers. The hypothesis for this experiment is that the combined effect of anti-resorptive drugs plus the standard in-flight exercise regimen will have a measurable effect on preventing space flight induced bone loss and strength and will reduce renal stone risk. To date, 4 crewmembers have completed the flight portion of the protocol in which crewmembers take a 70-mg alendronate tablet once a week before and during flight, starting 17 days before launch. Compared to previous ISS crewmembers (n=14) not taking alendronate, DXA measurements of the total hip BMD were significantly changed from -1.1 0.5%/mo to 0.04 0.3%/mo (p<0.01); QCT-determined trabecular BMD of the total hip was significantly changed from -2.3 1.0%/mo to -0.3 1.6%/mo (p<0.01). Significance was calculated from a one-tailed t test. While these results are encouraging, the current n (4) is small, and the large SDs indicate that while the means are improved there is still high variability in individual response. Four additional crewmembers have been recruited to participate

  1. In vivo measurement of subacromial space width during shoulder elevation: technique and preliminary results in patients following unilateral rotator cuff repair.

    PubMed

    Bey, Michael J; Brock, Stephanie K; Beierwaltes, William N; Zauel, Roger; Kolowich, Patricia A; Lock, Terrence R

    2007-08-01

    The shoulder's subacromial space is of significant clinical interest due to its association with rotator cuff disease. Previous studies have estimated the subacromial space width to be 2-17 mm, but no study has measured in vivo subacromial space width during shoulder motion. The purpose of this study was to measure the in vivo subacromial space width during shoulder elevation in patients following rotator cuff repair. Biplane X-ray images were collected during shoulder elevation of 11 patients who had undergone rotator cuff repair. Glenohumeral joint motion was measured from the biplane X-ray images for each subject's repaired and asymptomatic, contralateral shoulders. The joint motion data were combined with subject-specific CT models to measure the subacromial space width during shoulder motion. Subacromial space width decreased with shoulder elevation, ranging from 2.3 to 7.4 mm in the repaired shoulder and 1.2-7.1 mm in the contralateral shoulder. Subacromial space width in the repaired shoulder was only 0.5 mm less than the contralateral shoulder when averaged over 10-60 degrees of glenohumeral elevation. The results indicate that the humerus in the repaired shoulder is positioned more cranially on the glenoid than in the contralateral shoulder. It is unclear if these subtle differences in subacromial space width are due to the surgical procedure or post-operative stiffness, or if subacromial impingement contributed to the development of the rotator cuff tear. Future research will ascertain if these results represent a transient response to the surgery or a more fundamental difference in rotator cuff function between repaired and contralateral shoulders.

  2. Intraarterial Ultrasound in Pancreatic Cancer: Feasibility Study and Preliminary Results

    SciTech Connect

    Larena-Avellaneda, Axel; Timm, Stephan; Kickuth, Ralph; Kenn, Werner; Steger, Ulrich; Jurowich, Christian; Germer, Christoph-Thomas

    2010-08-15

    Despite technological advances in computed tomography (CT) and magnetic resonance imaging, the involvement of the celiac or mesenteric artery in pancreatic cancer remains uncertain in many cases. Infiltration of these vessels is important in making decisions about therapy choices but often can only be definitively determined through laparotomy. Local (intraarterial) ultrasound may increase diagnostic accuracy. Using the Volcano intravascular ultrasound (IVUS) system, we applied a transfemoral method to scan the celiac and mesenteric arteries directly intraarterial. This technique was used in five patients with suspected pancreatic cancer. Technical success was achieved in all cases. In one case, a short dissection of the mesenteric artery occurred but could be managed interventionally. In tumors that did not contact with the vessels, IVUS was unable to display the tissue pathology. Our main interest was the infiltration of the arteries. In one case, infiltration was certain in the CT scan but uncertain in two patients. In the latter two cases, IVUS correctly predicted infiltration in one and freedom from tumor in the other case. In our preliminary study, IVUS correctly predicted arterial infiltration in all cases. IVUS did not provide new information when the tumor was far away from the vessel. Compared with IVUS in the portal vein, the information about the artery is more detailed, and the vessel approach is easier. These results encouraged us to design a prospective study to evaluate the sensitivity and specificity of this method.

  3. Bioelectrical impedance for detecting and monitoring lymphedema in patients with breast cancer. Preliminary results of the florence nightingale breast study group.

    PubMed

    Erdogan Iyigun, Zeynep; Selamoglu, Derya; Alco, Gul; Pilancı, Kezban Nur; Ordu, Cetin; Agacayak, Filiz; Elbüken, Filiz; Bozdogan, Atilla; Ilgun, Serkan; Guler Uysal, Fusun; Ozmen, Vahit

    2015-03-01

    The aim of this study was to evaluate the efficacy of bioimpedance spectroscopy for the follow-up of patients with lymphedema in Turkey and its benefits in the diagnosis of stage 0, 1, and 2 lymphedema in patients who are under treatment for breast cancer. Thirty-seven female patients with breast cancer who underwent surgical procedures in our Breast Health Centre were followed up for lymphedema using bioimpedance, and clinical measurements were taken for a minimum period of 1 year at 3-month intervals. Patients who had been monitored regularly between November, 2011, and September, 2013, were enrolled to the study. In total, 8 patients developed lymphedema with an overall rate of 21.6%. Among the 8 patients who developed lymphedema, 4 had Stage 2, 1 had Stage 1, and 3 had Stage 0 lymphedema. Stage 0 lymphedema could not be detected with clinical measurements. During the patients' 1-year follow-up period using measurements of bioimpedance, a statistically significant relationship was observed between the occurrence of lymphedema and the disease characteristics. including the number of the extracted and remaining lymph nodes and the region of radiotherapy (p=0.042, p=0.024, p=0.040). Bioimpedance analysis seems to be a practical and reliable method for the early diagnosis of lymphedema. It is believed that regular monitoring of patients in the high-risk group using bioimpedance analyses increases the ability to treat lymphedema.

  4. METODO, a prospective observational study to assess the efficacy and tolerability of methadone in heroin-addicted patients undergoing a methadone maintenance treatment: preliminary results at baseline evaluation.

    PubMed

    D'Egidio, Pietro Fausto; Bignamini, Emanuele; De Vivo, Enrico; Leonardi, Claudio; Pieri, Maria Chiara; González-Saiz, Francisco; Lucchini, Alfio

    2013-12-01

    METODO (methadone efficacy therapy optimization dosage on-going) is a prospective observational study to assess the efficacy and tolerability of methadone in 500 heroin-addicted patients taking a methadone maintenance treatment, enrolled through 2010 to 2011 in five Italian sites, observed over 2 years. The Opiate Dosage Adequacy Scale has been used for the evaluation of the "adequacy" of the methadone dosage and to stratify patients in adequate and not adequate groups. The treatment efficacy has been evaluated in correlation to the dosage adequacy during the visits. Moreover, patients have been evaluated according to the retention rate and duration of retention in treatment and a series of questionnaires.

  5. Connecticut Transit (CTTRANSIT) Fuel Cell Transit Bus: Preliminary Evaluation Results

    SciTech Connect

    Chandler, K.; Eudy, L.

    2008-10-01

    This report provides preliminary results from a National Renewable Energy Laboratory evaluation of a protoptye fuel cell transit bus operating at Connecticut Transit in Hartford. Included are descriptions of the planned fuel cell bus demonstration and equipment; early results and agency experience are also provided.

  6. Modulation of Tryptophan/Serotonin Pathway by Probiotic Supplementation in Human Immunodeficiency Virus–Positive Patients: Preliminary Results of a New Study Approach

    PubMed Central

    Scheri, Giuseppe Corano; Fard, Saeid Najafi; Schietroma, Ivan; Mastrangelo, Andrea; Pinacchio, Claudia; Giustini, Noemi; Serafino, Sara; De Girolamo, Gabriella; Cavallari, Eugenio Nelson; Statzu, Maura; Laghi, Luca; Vullo, Annamaria; Ceccarelli, Giancarlo; Vullo, Vincenzo; d’Ettorre, Gabriella

    2017-01-01

    BACKGROUND To date, no data are available regarding the effects of probiotics on the pathway of tryptophan/serotonin metabolism among human immunodeficiency virus (HIV) 1–infected individuals. Because a condition of dysbiosis might be responsible for the altered use of tryptophan described in this population, the aim of this study was to investigate the link between probiotic supplementation and serotonin levels in combined antiretroviral therapy–treated patients and the subsistence of an interplay with inflammation. METHODS We conducted a pilot study that included 8 HIV-positive subjects. We collected blood and fecal samples before and after 6 months of probiotic supplementation, to measure the level of serotonin in serum and tryptophan in stool, the expression of CD38 and HLA-DR on peripheral CD4+ T lymphocytes (as immune activation markers), the expression of indoleamine 2,3-dioxygenase 1 messenger RNA (mRNA) and IFN-γ mRNA (as markers of tryptophan metabolism and systemic inflammation). RESULTS After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma. Moreover, a significant reduction in CD38 and HLA-DR expression on the surface of peripheral CD4+ T cells (P = .008) and a reduced expression of indoleamine 2,3-dioxygenase 1 mRNA on peripheral blood mononuclear cells (P = .04) were observed. CONCLUSIONS Considering that this probiotic (Vivomixx® in EU; Visbiome® in USA) has an influence on tryptophan metabolism, larger studies on this topic are needed. PMID:28607543

  7. Arterial surgery for sporadic hemiplegic migraine: preliminary results.

    PubMed

    Shevel, Elliot

    2014-05-01

    My aim was to report for the first time (to my knowledge) the successful treatment of 3 patients with sporadic hemiplegic migraine by surgical cautery of terminal branches of the external carotid artery under conscious sedation. Since the operations (between 1 and 2 years) none of the patients have had further attacks of migraine or hemiplegia. This preliminary report suggests that for patients with sporadic hemiplegic migraine with a confirmed arterial component, surgical cautery of selected terminal branches of the external carotid artery may be effective treatment. Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  8. Telemedicine-assisted home support for patients with advanced chronic obstructive pulmonary disease: preliminary results after nine-month follow-up.

    PubMed

    Vontetsianos, Th; Giovas, P; Katsaras, Th; Rigopoulou, A; Mpirmpa, G; Giaboudakis, P; Koyrelea, S; Kontopyrgias, G; Tsoulkas, B

    2005-01-01

    Eighteen well motivated patients with advanced chronic obstructive pulmonary disease, who had had at least four hospitalizations during the previous two years, were included in a home-based telemedicine study. A visiting nurse was equipped with a case containing a laptop computer and a number of medical devices, including an electrocardiogram recorder, spirometer, oximeter and blood pressure monitor. It also contained a videoconference camera, for realtime audiovisual connection with the hospital using the patient's TV set. A single ISDN line (128 kbit/s) was installed in each house before the study began. After nine months, there was a decrease in hospitalizations, emergency department visits and use of health services. The patient's disease knowledge and self-management also improved. It seems likely that adopting telemedicine in everyday clinical practice could substantially improve the care of chronically ill patients.

  9. In situ photoimmunotherapy for melanoma: preliminary clinical results

    NASA Astrophysics Data System (ADS)

    Naylor, Mark F.; Nordquist, Robert E.; Teauge, T. Kent; Perry, Lisa A.; Chen, Wei R.

    2006-02-01

    Although melanoma accounts for only 4% of skin cancer cases, it causes 79% of all skin cancer deaths. Patients with metastatic melanoma have a poor prognosis, and long term survival is only about 5% [1, 2]. Conventional therapies such as surgery and radiation therapy usually do not cure stage III or stage IV melanoma, while traditional chemotherapy is primarily palliative. Over the last decade we have been developing new methods for treating solid tumors like melanoma, first in animal models and now in humans. We present here preliminary results from a new technique that utilizes a combination of laser stimulation and drug therapy to stimulate brisk immunological responses in cases of advanced melanoma with cutaneous metastases. A high-power, near-infrared diode laser (805 nm) is used to kill tumors in situ and a topical toll-like receptor agonist (imiquimod cream, 5%) is used to intensify the resulting immunological response. This is essentially an in situ, tumor vaccine approach to treating solid tumors.

  10. Ultrathin angioscopic guidewire: preliminary in-vitro results

    NASA Astrophysics Data System (ADS)

    Castracane, James; Conerty, Michelle D.; Breisblatt, Warren

    1995-05-01

    One significant avenue for cost containment in medical care is the application of affordable spin-off technology. Innovative methods for the efficient prevention and treatment of atherosclerotic plaques in cardiac arteries will have significant implications for reducing health care costs in a large patient population. We report on preliminary work aimed at exploiting advanced sensing, fiber optic and materials technologies to create an innovative medical instrument: the Ultrathin Angioscopic Guidewire (UAG). The UAG uses an innovative method to combine high resolution fiber optic imaging bundles with flexible guidewire extensions into a integral unit having a diameter of less than 350 microns. The UAG would serve as the guidewire over a integral unit having a diameter of less than 350 microns. The UAG would serve as the guidewire over which the treatment catheter would ride eliminating repeated removal and reinsertion of the catheter for evaluation. The resulting images are coupled to a high resolution, image intensified detector. Use of digital image capture before and after treatment combined with frame processing allows for a quantitative evaluation of lesion removal and archival data to establish treatment efficacy. Once developed, this instrument will be particularly useful in conjunction with current interventional procedures. As a diagnostic tool, the intensifier in the UAG allows for sensitive imaging for application to in vivo bio/chemiluminescent immunoassays. We will present design details and discuss proof of principle results with the first prototype UAG.

  11. Postoperative simultaneous integrated boost-intensity modulated radiation therapy for patients with locoregionally advanced papillary thyroid carcinoma: preliminary results of a phase II trial and propensity score analysis.

    PubMed

    Lee, Eun Kyung; Lee, You Jin; Jung, Yuh-S; Ryu, Junsun; Kim, Tae Hyun; Lee, Chang Yoon; Ryu, Chang Hwan; Kim, Tae Sung; Kim, Seok Ki; Chung, Ki-Wook; Kim, Sang Soo; Kim, Dae Yong; Kim, Joo Young; Cho, Kwan Ho

    2015-03-01

    With recent technical advances in radiotherapy (RT) planning, simultaneous integrated boost intensity modulated radiotherapy (SIB-IMRT) has made possible the delivery of high radiation dose to the tumor, minimizing surrounding normal tissues. This study aimed to evaluate the clinical effectiveness and safety of postoperative SIB-IMRT in patients with locoregionally advanced papillary thyroid cancer (PTC). This was a propensity score-matched case control study conducted at a tertiary referring center. This study included locoregionally advanced patients with PTC (pT4 or N1b) who underwent thyroid cancer surgery and radioactive iodine ablation (RIA) followed by postoperative SIB-IMRT (RT group) under a phase II trial or no postoperative RT (Non-RT group) Intervention: Postoperative SIB-IMRT was the intervention. locoregional relapse-free survival (LRFS) was compared between RT group and Non-RT group. Multivariate analysis showed that several factors, including sex, American Thyroid Association risk category, and use of postoperative RT were significantly associated with LRFS in all 201 patients (P < .05 each). In the 118 propensity score-matched patients, there were no significant differences in baseline characteristics between the RT and Non-RT groups, but the LRFS rate was significantly higher in the RT than in the Non-RT group (4 y: 100% vs 84.6%, P = .002). Overall, SIB-IMRT was well tolerated, with no grade ≥3 toxicity, and was completed as planned in all patients. Postoperative SIB-IMRT is feasible and effective in improving locoregional control in patients with locally advanced PTC. Large-scale randomized studies are warranted.

  12. Hematopoietic peripheral circulating blood stem cells as an independent marker of good transfusion management in patients with β-thalassemia: results from a preliminary study.

    PubMed

    Napolitano, Mariasanta; Gerardi, Calogera; Di Lucia, Anna; Accardo, Pietro Andrea; Rizzuto, Luigi; Ferraro, Maria; Siragusa, Sergio; Buscemi, Filippo

    2016-04-01

    Beyond hemoglobin (Hb) levels and performance status, further surrogate markers of appropriate transfusion management should improve the quality of thalassemia care. We investigated the levels of peripheral circulating CD34+ stem cells as an independent marker of appropriate hematopoietic balance in patients with thalassemia. Peripheral circulating CD34+ stem cells, colony-forming unitgranulocyte, erythrocyte, macrophage, magakaryocyte (CF-GEMM), colony-forming unitgranulocyte/macrophage (CFU-GM), and erythroidburst-forming units (BFU-E) were assayed, according to standard procedures. Patients with thalassemia major (TM) and thalassemia intermedia (TI) were tested and compared to healthy controls. Demographic and clinical data were recorded. Overall, 56 patients with TM (median age, 35 years; range, 13-52 years) and 13 with TI (median age, 44 years; range, 27-67 years) were evaluated. Annual red blood cell (RBC) transfusion requirements ranged from 10 to 65 units in all patients except four nontransfused cases. A significant increase in peripheral circulating stem cells was observed in patients, in comparison with healthy controls. Nontransfused patients showed the mean highest levels of stem cells (CD34, 32.5 ± 14.8/μL; BFU-E, 41.3 ± 22.8/mL; CFU-GM, 19.6 ± 5.6/mL; CFU-GEMM, 9.0 ± 6.1/mL). CD34+ cell count was 6.9 ± 4.5/μL in TM (p = 0.014) and 11.8 ± 14.8/μL (p = 0.051) in TI. Furthermore, only in patients with TI was a significant increase in CFU-GEMM (3.0 ± 4.8 vs. 0.75 ± 2.05/mL, p = 0.0001) observed. At multivariate analysis, peripheral circulating CD34+ stem cells did not correlate with age, sex, smoking habit, number of RBCs units transfused, Hb levels, iron chelation therapy, history of splenectomy, and hypothyroidism. Circulating peripheral CD34 + stem cells are increased in β-thalassemia, in particular in nontransfused patients, compared to healthy controls. © 2016 AABB.

  13. Hydrogen-burn survival: preliminary thermal model and test results

    SciTech Connect

    McCulloch, W.H.; Ratzel, A.C.; Kempka, S.N.; Furgal, D.T.; Aragon, J.J.

    1982-08-01

    This report documents preliminary Hydrogen Burn Survival (HBS) Program experimental and analytical work conducted through February 1982. The effects of hydrogen deflagrations on safety-related equipment in nuclear power plant containment buildings are considered. Preliminary results from hydrogen deflagration experiments in the Sandia Variable Geometry Experimental System (VGES) are presented and analytical predictions for these tests are compared and discussed. Analytical estimates of component thermal responses to hydrogen deflagrations in the upper and lower compartments of an ice condenser, pressurized water reactor are also presented.

  14. Accounting for Variation in Patient Length of Stay in Naval Hospitals Using Diagnosis Related Groups (DRGs) as a Case Grouping Method. Preliminary Results.

    DTIC Science & Technology

    1983-11-01

    average length of stay Diagnosis Related Groups (DRGs...regularly review aggregate data such as average length of stay to monitor the performance of individual facilities* Yet interpretation of aggregate length...within individual facilities contribute -’ to patient average length of stay . Although it is difficult to quantify this facility factor, one

  15. Professional oral hygiene as a therapeutic option for pediatric patients with plasma cell gingivitis: preliminary results of a prospective case series.

    PubMed

    Arduino, Paolo G; D'Aiuto, Francesco; Cavallito, Claudio; Carcieri, Paola; Carbone, Mario; Conrotto, Davide; Defabianis, Patrizia; Broccoletti, Roberto

    2011-12-01

    Plasma cell gingivitis (PCG) is a rare, benign inflammatory condition of unclear etiology with no definitive standard of care ever reported to our knowledge. The aim of this case series is to ascertain the clinical efficacy of professional oral hygiene and periodontal therapy in younger individuals with a histologically confirmed diagnosis of PCG. All patients received non-surgical periodontal therapy, including oral hygiene instructions, and thorough supragingival scaling and polishing with the removal of all deposits and staining combined with the use of antimicrobials in a 9-week cohort study. Clinical outcome variables were recorded at baseline and 4 weeks after the intervention and included, as periodontal parameters, full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), the clinical extension of gingival involvement, and patient-related outcomes (visual analog score of pain). A total of 11 patients (six males and five females; mean age: 11 ± 0.86 years) were recruited. Four weeks after finishing the oral hygiene and periodontal therapy protocol, a statistically significant reduction was observed for FMPS (P = 0.000), FMBS (P = 0.000), reported pain (P = 0.003) and clinical gingival involvement (P = 0.003). Standard, professional oral hygiene procedures and non-surgical periodontal therapy including antimicrobials were associated with a marked improvement of clinical and patient-related outcomes in pediatric cases of PCG.

  16. MR elastography of the breast:preliminary clinical results.

    PubMed

    Lorenzen, J; Sinkus, R; Lorenzen, M; Dargatz, M; Leussler, C; Röschmann, P; Adam, G

    2002-07-01

    Imaging of breast tumors and various breast tissues using magnetic resonance (MR) elastography (MRE) to explore the potential of elasticity as a new parameter for the diagnosis of breast lesions. Low-frequency mechanical waves are transmitted into breast tissue by means of an oscillator. The local characteristics of the mechanical wave are determined by the underlying elastic properties of the tissue. Theses waves can be displayed by means of a motion-sensitive spin-echo MR sequence within the phase of the MR image. Elasticity reconstruction is performed on the basis of 8 "snapshots" of each wave within the three spatial directions. We performed in-vivo measurements in 15 female patients with malignant tumors of the breast, 5 patients with benign breast tumors, and 15 healthy volunteers. Malignant invasive breast tumors documented the highest values of elasticity with a median of 15.9 kPa and a wide range of stiffnesses between 8 and 28 kPa. In contrast, benign breast lesions represented low values of elasticity, which were significantly different from malignant breast tumors (median elasticity: 7.0 kPa; p = 0.0012). This was comparable to the stiffest tissue areas in healthy volunteers (median elasticity 7.0 kPa), whereas breast parenchyma (median: 2.5 kPa) and fatty breast tissue (median: 1.7 kPa) showed the lowest values of elasticity. Two invasive ductal carcinomas had elasticity values of 8 kPa and two stiff parenchyma areas in healthy volunteers had elasticities of 13 and 15 kPa. These lesions could not be differentiated by their elasticity. We conclude that MRE is a promising new imaging modality with the capability to assess the viscoelastic properties of breast tumors and the surrounding tissues. However, from our preliminary results in a small number of patients it is obvious that there is an overlap in the elasticity ranges of soft malignant tumors and stiff benign lesions.

  17. The 2dF Galaxy Redshift Survey: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Maddox, Steve; 2DF Galaxy Redshift Survey Team; Bland-Hawthorn, Joss; Cannon, Russell; Cole, Shaun; Colless, Matthew; Collins, Chris; Couch, Warrick; Dalton, Gavin; Driver, Simon; Ellis, Richard; Efstathiou, George; Folkes, Simon; Frenk, Carlos; Glazebrook, Karl; Kaiser, Nick; Lahav, Ofer; Lumsden, Stuart; Peterson, Bruce; Peacock, John; Sutherland, Will; Taylor, Keith

    Spectroscopic observations for a new survey of 250 000 galaxy redshifts are underway, using the 2dF instrument at the AAT. The input galaxy catalogue and commissioning data are described. The first result from the preliminary data is a new estimate of the galaxy luminosity function at = 0.1.

  18. Synthetic bone substitute material comparable with xenogeneic material for bone tissue regeneration in oral cancer patients: First and preliminary histological, histomorphometrical and clinical results.

    PubMed

    Ghanaati, Shahram; Barbeck, Mike; Lorenz, Jonas; Stuebinger, Stefan; Seitz, Oliver; Landes, Constantin; Kovács, Adorján F; Kirkpatrick, Charles J; Sader, Robert A

    2013-07-01

    The present study was first to evaluate the material-specific cellular tissue response of patients with head and neck cancer to a nanocrystalline hydroxyapatite bone substitute NanoBone (NB) in comparison with a deproteinized bovine bone matrix Bio-Oss (BO) after implantation into the sinus cavity. Eight patients with tumor resection for oral cancer and severely resorbed maxillary bone received materials according to a split mouth design for 6 months. Bone cores were harvested prior to implantation and analyzed histologically and histomorphometrically. Implant survival was followed-up to 2 years after placement. Histologically, NB underwent a higher vascularization and induced significantly more tartrate-resistant acid phosphatase-positive (TRAP-positive) multinucleated giant cells when compared with BO, which induced mainly mononuclear cells. No significant difference was observed in the extent of new bone formation between both groups. The clinical follow-up showed undisturbed healing of all implants in the BO-group, whereas the loss of one implant was observed in the NB-group. Within its limits, the present study showed for the first time that both material classes evaluated, despite their induction of different cellular tissue reactions, may be useful as augmentation materials for dental and maxillofacial surgical applications, particularly in patients who previously had oral cancer.

  19. 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon β-1a: results of a preliminary study

    PubMed Central

    Sarchielli, P; Presciutti, O; Tarducci, R; Gobbi, G; Alberti, A; Pelliccioli, G; Orlacchio, A; Gallai, V

    1998-01-01

    BACKGROUND—In vivo magnetic resonance spectroscopy (MRS) has been widely used to assess biochemical changes which occur in demyelinating lesions in white matter of patients with multiple sclerosis. It has been suggested that metabolic variations evidenced by MRS are sensitive indicators of the effects of immunomodulatory treatments in this disease.
 Given the recent finding of an increase in the disease activity in patients with multiple sclerosis treated with interferon (IFN) β-1a in the first period of treatment,1H MRS was used to investigate further the modification in brain metabolic indices, particularly in the first phase of IFN βtreatment.
METHODS—A 1H MRS study was performed on five patients with relapsing-remitting multiple sclerosis who were being treated with intramuscular IFN β-1a (6 million units/week) for six months and on five untreated patients. The mean age, duration of the disease, and expanded disability status scores (EDSS) of the two groups were similar. Patients were evaluated at the beginning of the study and in the first, third, and sixth months of treatment.
RESULTS—In the multiple sclerosis white matter lesions, N-acetylaspartate (NAA), choline (Cho), inositol (Ins), and creatine (Cr) peaks did not vary significantly over the entire period of the study in the untreated group.
 In the treated group there was a significant increase in the Cho peak area at the first month compared with the pretreatment period, and this increase continued in the third and sixth months (p<0.001). A slight but not significant rise in the Cho peak was also found in normal appearing white matter in the patient group undergoing treatment with IFN β-1a. The increase in Cho and the lack of significant changes in Cr and NAA peaks induced a significant rise in Cho/Cr and Cho/NAA ratios over the entire period of treatment compared with those at the beginning of the study (p<0.02 and p<0.005 respectively).
 In the treated group there was a slight but

  20. Improved kit formulation for preparation of (99m)Tc-HYNIC-TOC: results of preliminary clinical evaluation in imaging patients with neuroendocrine tumors.

    PubMed

    Korde, Aruna; Mallia, Madhava; Shinto, Ajit; Sarma, H D; Samuel, Grace; Banerjee, Sharmila

    2014-11-01

    (99m)Tc-HYNIC-TOC is a cost-effective and logistically viable agent for scintigraphy of neuroendocrine tumors overexpressing somatostatin receptors as compared with [(111)In-DTPA-D-Phe(1)] Octreotide (Octreoscan(®)). Several studies have been reported, wherein the efficacy of this agent is demonstrated. In the present article, the authors report the preparation of a single-vial HYNIC-TOC kit suitable for the preparation of 4-5 patient doses (15 mCi/patient) of (99m)Tc-HYNIC-TOC. The kits were tested for sterility and bacterial endotoxins to assure safety of the product. A significant modification in this kit is the inclusion of buffer in the kit itself, unlike in commercially available kits where the buffer solution has to be added during preparation. (99m)Tc-HYNIC-TOC was prepared by adding 20-80 mCi (740-2960 MBq) of freshly eluted Na(99m)TcO4 in 1-3 mL of sterile saline directly into the kit vial and heating the vial in a water bath at 100°C for 20 minutes. The labeling yield and radiochemical purity of (99m)Tc-HYNIC-TOC, prepared using the lyophilized cold kit, were consistently >90%. The kits were evaluated over a period of 9 months and found to be stable when stored at -20°C. Limited clinical studies performed with the (99m)Tc-HYNIC-TOC, formulated using the kit, showed adequate sensitivity and specificity for the detection of gasteroenteropancreatic neuroendocrine tumors.

  1. The Added Value of Log File Analyses of the Use of a Personal Health Record for Patients With Type 2 Diabetes Mellitus: Preliminary Results.

    PubMed

    Sieverink, Floor; Kelders, Saskia M; Braakman-Jansen, Louise M A; van Gemert-Pijnen, Julia E W C

    2014-03-01

    The electronic personal health record (PHR) is a promising technology for improving the quality of chronic disease management. Until now, evaluations of such systems have provided only little insight into why a particular outcome occurred. The aim of this study is to gain insight into the navigation process (what functionalities are used, and in what sequence) of e-Vita, a PHR for patients with type 2 diabetes mellitus (T2DM), to increase the efficiency of the system and improve the long-term adherence. Log data of the first visits in the first 6 weeks after the release of a renewed version of e-Vita were analyzed to identify the usage patterns that emerge when users explore a new application. After receiving the invitation, 28% of all registered users visited e-Vita. In total, 70 unique usage patterns could be identified. When users visited the education service first, 93% of all users ended their session. Most users visited either 1 or 5 or more services during their first session, but the distribution of the routes was diffuse. In conclusion, log file analyses can provide valuable prompts for improving the system design of a PHR. In this way, the match between the system and its users and the long-term adherence has the potential to increase. © 2014 Diabetes Technology Society.

  2. Preliminary results toward injection locking of an incoherent laser array

    NASA Technical Reports Server (NTRS)

    Daher, J.

    1986-01-01

    The preliminary results of phase locking an incoherent laser array to a master source in an attempt to achieve coherent operation are presented. The techniques necessary to demonstrate phase locking are described along with some topics for future consideration. As expected, the results obtained suggest that injection locking of an array, where the spacing between adjacent longitudinal modes of its elements is significantly larger than the locking bandwidth, may not be feasible.

  3. Hellenic Amateur Astronomy Association's activities: Preliminary results on Perseids 2010

    NASA Astrophysics Data System (ADS)

    Maravelias, G.

    2011-01-01

    Preliminary results on the Perseids 2010 are presented. Visual and video observations were obtained by the author and a first reduction of the visual data shows that a maximum of ZHR ~120 was reached during the night 12-13 of August 2010. Moreover, a video setup was tested (DMK camera and UFO Capture v2) and the results show that, under some limitations, valuable data can be obtained.

  4. Preliminary Results from the ESO Slice Project (ESP)

    NASA Astrophysics Data System (ADS)

    Vettolani, G.; Zucca, E.; Cappi, A.; Merighi, R.; Mignoli, M.; Stirpe, G.; Zamorani, G.; MacGillivray, H.; Collins, C.; Balkowski, C.; Alimi, J.; Blanchard, A.; Cayatte, V.; Felenbock, P.; Maurogordato, S.; Proust, D.; Chincarini, G.; Guzzo, L.; Maccagni, D.; Scaramella, R.; Ramella, M.

    We present the first results of a galaxy redshift survey, ESO Slice Project (ESP), we are accomplishing as an ESO Key-Project over about 30 square degrees in a region near the South Galactic Pole. The limiting magnitude is b_J = 19.4. Observations have been almost completed and about 90% of the data obtained so far has been reduced providing about 3000 galaxy redshifts. We present some preliminary results concerning the large scale galaxy distribution and their luminosity function.

  5. Iron in hereditary retinal degeneration: PIXE microanalysis. Preliminary results

    NASA Astrophysics Data System (ADS)

    Sergeant, C.; Gouget, B.; Llabador, Y.; Simonoff, M.; Yefimova, M.; Courtois, Y.; Jeanny, J. C.

    1999-10-01

    Several types of hereditary retinal degeneration with progressive alteration of photoreceptors exist in men and animals. Recent immunohistochemical results have shown strong degradation of transferrin, the protein responsible for iron transport, in retinas of rats with hereditary retinal degeneration. Freeze-dried thin sections of rat retinas from different stages of the disease, and respective coeval control sections, have been analyzed using nuclear microprobe. In this first part of the study, the rat retinas at post-natal stages of 35 and 45 days have been analyzed. The sample preparation and the post-irradiation staining to determine precisely the retinal layers involved are described. Preliminary results of element distributions (K, Ca, Fe) in the rat retina layers are discussed. A very high content of calcium in the choriocapillaris of dystrophic rat retinas was observed. Preliminary results on iron distribution in the rat retina layers are presented.

  6. [Preliminary results on the residence distribution at birth of patients with Alzheimer's disease in the Saguenay-Lac-Saint-Jean/Quebec (the IMAGE project)].

    PubMed

    Emard, J F; Thouez, J P; Mathieu, J; Boily, C; Beaudry, M; Cholette, A; Robitaille, Y; Bouchard, R; Gauvreau, D

    1992-01-01

    The IMAGE Project is pursuing the establishment of a population-based registry of Alzheimer's disease (AD) cases in the Saguenay-Lac-Saint-Jean (SLSJ) (Quebec). The authors report on the spatial distribution at birth of 221 possible, probable and definite cases. A large network of key-informants for screening AD cases has been established over SLSJ. The spatial distribution of cases at birth and at the onset of disease has been computed by calculating the Alzheimer birth rate (ABR) on the basis of three scales: six specific geographical spheres of screening, all municipalities, and the public health departments. The statistical significance of results was determined using the theoretical Poisson and the Chi square distributions. ABR for each of the geographical spheres of screening showed no statistically significant differences considering either residence at the onset of the disease or residence at birth. Furthermore, differences were observed between rural and urban areas with an interesting trend for a higher number of cases than expected in one area of SLSJ. The spatial distribution of cases considered on the basis of residence at birth appears to show a different pattern, but no significant, from that measured on the basis of residence at the onset of disease. Screening of cases is actively being pursued all across SLSJ by the IMAGE network. There is a clear trend towards rural residence at birth of cases. It remains to see whether or not this observation is due to a geographical concentration of familial cases.

  7. Preliminary Results of the MOSES II 2015 Flight

    NASA Astrophysics Data System (ADS)

    Smart, Roy; Courrier, Hans; Kankelborg, Charles

    2016-05-01

    The Multi-Order Extreme Ultraviolet Spectrograph (MOSES) is a slitless spectrograph which aims to produce simultaneous spatial-spectral imaging of the solar transition region. This is accomplished through a multilayer concave diffraction grating which produces three images for the spectral orders m = 0, ± 1. The multilayer coating provides a narrow passband, dominated by Ne VII (46.5 nm), which allows the three images to be compared in order to determine line broadenings and identify explosive events in the Solar Transition Region. Here, we examine the preliminary results of MOSES II, the instrument’s second flight which was launched on a sounding rocket from White Sands Missile Range, NM in August 2015. We present the first images of the Sun in Ne VII since Skylab and the preliminary results of observed doppler shifts within an active region.

  8. Impact of radiotherapy on implant-based prosthetic rehabilitation in patients with head and neck cancer: A prospective observational study on implant survival and quality of life-Preliminary results.

    PubMed

    Ettl, Tobias; Weindler, Janet; Gosau, Martin; Müller, Steffen; Hautmann, Matthias; Zeman, Florian; Koller, Michael; Papavasileiou, Dimitrios; Bürgers, Ralf; Driemel, Oliver; Schneider, Isabel; Klingelhöffer, Christoph; Meier, Johannes; Wahlmann, Ulrich; Reichert, Torsten E

    2016-09-01

    To study implant-based prosthetic rehabilitation of head and neck cancer patients with focus on implant survival and quality of life. The prospective observational study presents preliminary results of 29 edentulous head neck cancer patients (20 patients after radiotherapy) with 165 OsseoSpeed implants. Implant success after 1-year follow-up was evaluated by means of the Albrektsson criteria. Quality of life was analysed with the EORTC QLQ-C30, QLQ-H&N35, and OHIP 14 questionnaires. The overall implant survival rate after 1 year was 95.2% (157/165). Implant success measured by the Albrektsson criteria showed a lower success rate of 86.7% (143/165), mainly because of peri-implant marginal bone loss with a mean of 0.8 mm after 1 year. Xerostomia (p = 0.008), implant insertion within the radiation target volume (p = 0.09), implantation in transplanted bone (p = 0.05), and smoking (p = 0.041) were the main reasons for implant failure, followed by D4 bone quality, maxillary implant site, and insufficient primary stability. Speaking, swallowing, eating, as well as social integration and individual self-confidence had considerably improved 1 year after denture placement compared to before treatment. Implant-based prosthetic rehabilitation of head and neck cancer patients is possible at a calculable risk and significantly improves patients' quality of life. Copyright © 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  9. Preliminary results of the echo-seeding experiment at SLAC

    SciTech Connect

    Xiang, D.; Colby, E.; Ding, Y.; Dunning, M.; Frederico, J.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T.O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; Corlett, J.; Qiang, J.; Penn, G.; Prestemon, S.; Schlueter, R.; Venturini, M.; Wan, W.; Pernet, P-L.

    2010-05-23

    ECHO-7 is a proof-of-principle echo-enabled harmonic generation FEL experiment in the Next Linear Collider Test Accelerator (NLCTA) at SLAC. The experiment aims to generate coherent radiation at 318 nm and 227 nm, which are the 5th and 7th harmonic of the infrared seed laser. In this paper we present the preliminary results from the commissioning run of the completed experimental setup which started in April 2010.

  10. Shoe-box orbit determination system for SMM preliminary results

    NASA Technical Reports Server (NTRS)

    Tasaki, K. K.; Goorevich, C.

    1979-01-01

    The implementation of both sequential and batch methods of estimation on IMP-16 microprocessors was investigated. Simulated data was used from a tracking and data relay satellite whose target satellite was the Solar Maximum Mission. An interesting feature of the hardware was the use of two interconnected IMP-16's. Some preliminary results from the study, as well as the difficulties and advantages in the use of microprocessors, are presented.

  11. 9.4T Human MRI: Preliminary Results

    PubMed Central

    Vaughan, Thomas; DelaBarre, Lance; Snyder, Carl; Tian, Jinfeng; Akgun, Can; Shrivastava, Devashish; Liu, Wanzahn; Olson, Chris; Adriany, Gregor; Strupp, John; Andersen, Peter; Gopinath, Anand; van de Moortele, Pierre-Francois; Garwood, Michael; Ugurbil, Kamil

    2014-01-01

    This work reports the preliminary results of the first human images at the new high-field benchmark of 9.4T. A 65-cm-diameter bore magnet was used together with an asymmetric 40-cm-diameter head gradient and shim set. A multichannel transmission line (transverse electromagnetic (TEM)) head coil was driven by a programmable parallel transceiver to control the relative phase and magnitude of each channel independently. These new RF field control methods facilitated compensation for RF artifacts attributed to destructive interference patterns, in order to achieve homogeneous 9.4T head images or localize anatomic targets. Prior to FDA investigational device exemptions (IDEs) and internal review board (IRB)-approved human studies, preliminary RF safety studies were performed on porcine models. These data are reported together with exit interview results from the first 44 human volunteers. Although several points for improvement are discussed, the preliminary results demonstrate the feasibility of safe and successful human imaging at 9.4T. PMID:17075852

  12. Preliminary results of SPIRAL-2 thermo mechanical neutron converter characteristics

    NASA Astrophysics Data System (ADS)

    Udup, E.; Acosta, G.; Bermúdez, J.; Sajo-Bohus, L.; Tecchio, L.

    2012-02-01

    A preliminary design of a neutron converter module (NCM) for SPIRAL 2 Project is presented, main characteristics are given. Neutrons, produced by bombarding a carbon converter with a 40 MeV deuteron beam, 5 mA current for power up to 200 kW, induce fission reactions in target. The neutron converter, a high speed rotating wheel, operates at the temperature range between 1650-1850 °C. Vacuum restrictions and material radiation degradation, as well as a continuous three month operation were considered into structural analysis employing the ANSYS software. Preliminary tests indicate that the assembly withstands operating conditions under a vacuum up to 10-4 mbar, temperature up to 350°C, lack of lubricant and a radiation dose rate around 105 Gy/h. The results of thermomechanical simulations, considering temperature gradients, deformation and equivalent stress are presented.

  13. Preliminary results on heavy flavor physics at SLD

    SciTech Connect

    Usher, T.

    1994-12-01

    The author reports on preliminary heavy flavor physics results from the SLD detector at the SLAC Linear Collider. Efficient tagging of b{bar b} events is achieved with an impact parameter technique that takes advantage of the small and stable interaction point of the SLC and all charged tracks in Z{sup 0} decays. This technique is applied to samples of Z{sup 0} events collected during the 1992 and 1993 physics runs. Preliminary measurements of the ratio R{sub b} = {Gamma}(Z{sup 0} {yields} b{bar b})/{Gamma}(Z{sup 0} {yields} hadrons) and the average B hadron lifetime <{tau}{sub B}> are reported. In a sample of 27K Z{sup 0} events, values of R{sub b} = 0.235 {+-} 0.006(stat.) {+-} 0.018(syst.) and <{tau}{sub B}> = 1.53 {+-} 0.006(stat.) {+-} 0.018(syst.) are obtained. In addition, the first measurement of the left-right asymmetry A{sub b} is reported. Using a sample of 38K Z{sup 0} events with a luminosity weighted electron polarization of 62%, the author obtains a preliminary value of A{sub b} = 0.94 {+-} 0.006(stat.) {+-} 0.018(syst.).

  14. BPM 37093: Preliminary Results from XCOV 16 and XCOV 17

    NASA Astrophysics Data System (ADS)

    Kanaan, A.; Nitta-Kleinman, A.; Winget, D. E.; Kepler, S. O.; Montgomery, M.; WET Team

    BPM 37093 is a 1.1 M_sun\\ ZZ Ceti star. This star's temperature (~ 11 000 K) and high mass (~ 1.1 M_sun) imply that it should be crystallized throughout most of its core, the exact fraction depending on its core composition. BPM 37093 is the first object where the results of crystallization theory can be probed observationally. If the star is crystallized its pulsation spectrum should differ significantly from non-crystallized pulsating stars. In this paper we report our preliminary results from the analysis of WET data obtained in 1998 and 1999.

  15. Preliminary Results on Uncertainty Quantification for Pattern Analytics

    SciTech Connect

    Stracuzzi, David John; Brost, Randolph; Chen, Maximillian Gene; Malinas, Rebecca; Peterson, Matthew Gregor; Phillips, Cynthia A.; Robinson, David G.; Woodbridge, Diane

    2015-09-01

    This report summarizes preliminary research into uncertainty quantification for pattern ana- lytics within the context of the Pattern Analytics to Support High-Performance Exploitation and Reasoning (PANTHER) project. The primary focus of PANTHER was to make large quantities of remote sensing data searchable by analysts. The work described in this re- port adds nuance to both the initial data preparation steps and the search process. Search queries are transformed from does the specified pattern exist in the data? to how certain is the system that the returned results match the query? We show example results for both data processing and search, and discuss a number of possible improvements for each.

  16. Helium at White Dwarf Photospheric Conditions: Preliminary Laboratory Results

    NASA Astrophysics Data System (ADS)

    Schaeuble, M.; Falcon, R. E.; Gomez, T. A.; Winget, D. E.; Montgomery, M. H.; Bailey, J. E.

    2017-03-01

    We present preliminary results of an experimental study exploring helium at photospheric conditions of white dwarf stars. These data were collected at Sandia National Laboratories' Z-machine, the largest x-ray source on earth. Our helium results could have many applications ranging from validating current DB white dwarf model atmospheres to providing accurate He pressure shifts at varying temperatures and densities. In a much broader context, these helium data can be used to guide theoretical developments in new continuum-lowering models for two-electron atoms. We also discuss future applications of our updated experimental design, which enables us to sample a greater range of densities, temperatures, and gas compositions.

  17. Intraluminal brachytherapy in the treatment of oesophageal cancers--some preliminary results.

    PubMed

    Wee, J T; Theobald, D R; Chua, E J

    1994-03-01

    Cancer of the oesophagus is the sixth commonest cancer in males in Singapore. The majority occur in the elderly and patients are often debilitated at presentation. Treatment is often aimed at palliation only. In this article, the preliminary results of 15 patients treated solely on a high dose rate remote afterloading Gammamed brachytherapy machine with an Iridium 192 (Ir192) source are reported. The patients were given 15 Gray (Gy) in a single or two 7.5 Gray fractions. All the patients treated had some improvement of their dysphagia, and seven out of 11 (63%) evaluable patients had symptom improvement lasting at least 11 weeks.

  18. Preliminary investigation into aerosol mobilization resulting from fusion reactor disruptions

    SciTech Connect

    Sharpe, J.P.; Bourham, M.A.; Gilligan, J.G.

    1996-12-31

    An experimental system has been developed to study disruption-induced aerosol mobilization for fusion accident analysis. The SIRENS high heat flux facility at North Carolina State University has been modified to closely simulate disruption conditions expected in tokamak reactors. A hot vapor is formed by an ablation-controlled arc and expansion cooled into a glass chamber, where particle condensation and growth occur. The particles are collected and analyzed for relevant transport properties (e.g. size distribution and shape). Particle characterization methods are discussed, and preliminary results based on simple analysis techniques are given. 2 refs., 6 figs.

  19. Preliminary results of an intercomparison of total ozone spectrophotometers

    NASA Technical Reports Server (NTRS)

    Parsons, C. L.; Gerlach, J. C.; Williams, M. E.; Kerr, J. B.

    1981-01-01

    Preliminary results from an intercomparison of five total ozone spectrophotometers are presented. These are the Dobson spectrophotometer, the USSR M-83 ozonometer, the Canterbury filter photometer, the SenTran Company filter photometer, and the Brewer grating spectrophotometer. The pertinent characteristics of each are described, and conclusions are drawn about the agreement of each instrument's measurements with the Dobson's values over a time period of nearly one year. A discussion of the importance of calibration and long-term stability and reliability is included.

  20. Preliminary results of an intercomparison of total ozone spectrophotometers

    NASA Technical Reports Server (NTRS)

    Parsons, C. L.; Gerlach, J. C.; Williams, M. E.; Kerr, J. B.

    1981-01-01

    Preliminary results from an intercomparison of five total ozone spectrophotometers are presented. These are the Dobson spectrophotometer, the USSR M-83 ozonometer, the Canterbury filter photometer, the SenTran Company filter photometer, and the Brewer grating spectrophotometer. The pertinent characteristics of each are described, and conclusions are drawn about the agreement of each instrument's measurements with the Dobson's values over a time period of nearly one year. A discussion of the importance of calibration and long-term stability and reliability is included.

  1. Preliminary results of SMM exposed aluminized Kapton and silvered Teflon

    NASA Technical Reports Server (NTRS)

    Santos-Mason, B.

    1985-01-01

    Early Space Shuttle flights revealed that organic materials, such as those used in thermal control blankets and paints in the payload bay, were adversely affected in the low Earth orbit environment. Examination of eroded surfaces on these early flights and materials experiments performed on subsequent flights led to the conclusion that atomic oxygen present at Shuttle operating altitudes was responsible for surface degradation. The Solar Maximum Mission provided surfaces that had been exposed in real time to atomic oxygen and ultraviolet radiation. Preliminary results of studies of the microscopic surface effects on silvered Teflon and aluminized Kapton used for thermal control on the Solar Maximum Mission are presented.

  2. Preliminary science results of Voyager 1 Saturn encounter

    NASA Technical Reports Server (NTRS)

    Bane, D.

    1981-01-01

    Preliminary science results of the Voyager 1 encounter of the planet Saturn are reported. On August 22, 1980, the spacecraft was 109 million km (68 million mi) from Saturn. Closest approach to Saturn took place on November 12, at 3:46 p.m. (PDT), when the spacecraft passed 126,000 km (78,000 mi) from the cloud tops. Measurements of the atmosphere, wind speed, radiation, six surrounding rings, and the planet's old and newly found satellites were recorded. The encounter ended December 15, 1980. The spacecraft took more than 17,500 photographs of Saturn and its satellites.

  3. Preliminary results from a shallow water benthic grazing study

    USGS Publications Warehouse

    Jones, N.L.; Monismith, Stephen G.; Thompson, Janet K.

    2005-01-01

    Despite great improvements in our knowledge on the effects of benthic grazers on seston concentrations in water columns, the effects of different hydrodynamic conditions on grazing rates has not been formulated. This makes it difficult to assess the system-wide effect of the benthic ecosystem on phytoplankton concentrations. Furthermore, it affects our ability to predict the potential success of a benthic species, such as the invasive clams Corbicula fluminea and Potamocorbula amurensis. This paper presents the preliminary results of a control volume approach to elucidate the effect of different hydrodynamic conditions on the grazing rates of Corbicula fluminea.

  4. V and V Efforts of Auroral Precipitation Models: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Zheng, Yihua; Kuznetsova, Masha; Rastaetter, Lutz; Hesse, Michael

    2011-01-01

    Auroral precipitation models have been valuable both in terms of space weather applications and space science research. Yet very limited testing has been performed regarding model performance. A variety of auroral models are available, including empirical models that are parameterized by geomagnetic indices or upstream solar wind conditions, now casting models that are based on satellite observations, or those derived from physics-based, coupled global models. In this presentation, we will show our preliminary results regarding V&V efforts of some of the models.

  5. Microwave remote sensing of snow experiment description and preliminary results

    NASA Technical Reports Server (NTRS)

    Ulaby, F. T. (Principal Investigator); Stiles, W. H.; Hanson, B. C.

    1977-01-01

    The active and passive microwave responses to snow were investigated at a site near Steamboat Springs, Colorado during the February and March winter months. The microwave equipment was mounted atop truck-mounted booms. Data were acquired at numerous frequencies, polarizations, and angles of incidence for a variety of snow conditions. The experiment description, the characteristics of the microwave and ground truth instruments, and the results of a preliminary analysis of a small portion of the total data volume acquired in Colorado are documented.

  6. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    NASA Astrophysics Data System (ADS)

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-07-01

    Preliminary results of a 600 J (3.7 μF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0±0.5 μbar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  7. Preliminary Results from the Space Probe Pioneer V

    NASA Technical Reports Server (NTRS)

    Fan, C. Y.; Meyer, P.; Simpson, J. A.

    1960-01-01

    The space probe Pioneer V was launched March 11, 1960, into an orbit around the sun and inside the orbit of earth. The scientific apparatus included instruments identical with the University of Chicago apparatus used on Explorer VI [Fan, Meyer, and Simpson, 1960b], namely, energetic particle detectors which measure fluxes of protons with energies greater than 75 Mev, electrons with energies greater than 15 Mev, and the bremsstrahlung from electrons and y rays of lower energy. Simultaneously with the measurements in Pioneer V a series of four neutron monitor piles were recording the changes in cosmic radiation intensity at the earth. We report here on some preliminary results obtained from the Chicago experiments during the time within which Pioneer V traveled to a distance of approximately 8 x 10 km from earth. Beginning on March 20, solar activity rapidly increased with many solar flares, radio noise bursts, etc., over a period of 10 days. Most of our results relate to this period. The preliminary data are given in Figures 1 and 2.

  8. Frist preliminary results of carbon dioxide retrieval algorithm

    NASA Astrophysics Data System (ADS)

    Jung, Y.; Kim, W. V.; Lee, H.; Kim, J.; Boesch, H.

    2013-12-01

    The significant increase in atmospheric carbon dioxide (CO2) over the last two hundred years represents critical variations both to the atmosphere and the global carbon cycle. Satellite measurement is one of the most effective approaches to monitor the global distributions of CO2 with high spatio-temporal resolutions and is expected to improve the accuracy of carbon source and sink estimates (Rayner and O'Brien, 2001; Houweling et al., 2004). The Greenhouse Gases Observing SATellite (GOSAT), which was launched on January 2009, is the world's first satellite dedicated to measure the atmospheric concentrations of CO2 from space. Even though many studies to develop the CO2 retrieval algorithms are performed, there have been serious limitations in spatial coverage and uncertainties due to aerosols and thin cirrus clouds. In this study, we demonstrate our retrieval algorithms of CO2 concentrations from GOSAT and show its preliminary results showing the variations CO2 concentration in global. The quality of the preliminary results in this study will be evaluated through comparison with collocated ground-based observations at several TCCON sites. In the future, we plan to investigate interferences by aerosols using our independent aerosol retrieval algorithms and improve its retrieval quality. This study would be informative to study the estimate the carbon sources and sinks in more detail.

  9. Preliminary Results Of A 600 Joules Small Plasma Focus Device

    SciTech Connect

    Lee, S. H.; Yap, S. L.; Wong, C. S.

    2009-07-07

    Preliminary results of a 600 J (3.7 muF, 18 kV) Mather type plasma focus device operated at low pressure will be presented. The discharge is formed between a solid anode with length of 6 cm and six symmetrically and coaxially arranged cathode rods of same lengths. The cathode base is profiled in a knife-edge design and a set of coaxial plasma gun are attached to it in order to initiate the breakdown and enhance the current sheath formation. The experiments have been performed in argon gas under a low pressure condition of several microbars. The discharge current and the voltage across the electrodes during the discharge are measured with high voltage probe and current coil. The current and voltage characteristics are used to determine the possible range of operating pressure that gives good focusing action. At a narrow pressure regime of 9.0+-0.5 mubar, focusing action is observed with good reproducibility. Preliminary result of ion beam energy is presented. More work will be carried out to investigate the radiation output.

  10. Immersive virtual environment for visuo-vestibular therapy: preliminary results.

    PubMed

    Gascuel, J D; Payno, H; Schmerber, S; Martin, O

    2012-01-01

    The sense of equilibrium aggregates several interacting cues. On vestibular areflexic patients, vision plays a major role. We developed an immersive therapeutic platform, based on 3D opto-kinetic stimulation that enables to tune the difficulty of the balance task by managing the type of optic flow and its speed. The balance adjustments are recorded by a force plate, quantified by the length of the center of pressure trajectory and detection of disequilibrium corrections (leans, compensation step). Preliminary analysis shows that (i) patients report a strong immersion feeling in the motion flow, triggering intense motor response to "fight against fall"; (ii) the ANOVA factorial design shows a significant effect of flow speed, session number and gaze anchor impact. In conclusion, this study shows that 3D immersive stimulation removes essential limits of traditional opto-kinetic stimulators (limited 2D motions and remaining fixed background cues). Moreover, the immersive optic flow stimulation is an efficient tool to induce balance adaptive reactions in vestibular patients. Hence, such a platform appears to be a powerful therapeutic tool for training and relearning of balance control processes.

  11. Magnetic Field Observations near Mercury: Preliminary Results from Mariner 10.

    PubMed

    Ness, N F; Behannon, K W; Lepping, R P; Whang, Y C; Schatten, K H

    1974-07-12

    Results are presented from a preliminary analysis of data obtained near Mercury on 29 March 1974 by the NASA-GSFC magnetic field experiment on Mariner 10. Rather unexpectedly, a very well-developed, detached bow shock wave, which develops as the super-Alfvénic solar wind interacts with the planet, has been observed. In addition, a magnetosphere-like region, with maximum field strength of 98 gammas at closest approach (704 kilometers altitude), has been observed, contained within boundaries similar to the terrestrial magnetopause. The obstacle deflecting the solar wind flow is global in size, but the origin of the enhanced magnetic field has not yet been uniquely established. The field may be intrinsic to the planet and distorted by interaction with the solar wind. It may also be associated with a complex induction process whereby the planetary interior-atmosphere-ionosphere interacts with the solar wind flow to generate the observed field by a dynamo action. The complete body of data favors the preliminary conclusion that Mercury has an intrinsic magnetic field. If this is correct, it represents a major scientific discovery in planetary magnetism and will have considerable impact on studies of the origin of the solar system.

  12. Preliminary test results with a Stirling Laboratory Research Engine

    NASA Technical Reports Server (NTRS)

    Hoehn, F. W.; Nguyen, B. D.; Schmit, D. D.

    1979-01-01

    The Jet Propulsion Laboratory has designed, assembled, and initiated testing of a Stirling Laboratory Research Engine (SLRE). This preprototype engine provides a research tool to support the development of a broad range of analytical modeling and experimental efforts. The SLRE is a horizontally opposed, two-piston, single-acting Stirling engine with a split crankshaft drive mechanism. The paper discusses the preliminary results obtained during engine motoring tests and compares these results with two different analytical prediction models. Comparisons are made between experiment, the classical Schmidt analysis, and the JPL Stirling Cycle Analysis Model (SCAM). SCAM is a computerized one-dimensional, cyclic, compressible flow model of the SLRE and consists of a compilation of individual component subroutines. The formulation and current state of development of the SCAM program is briefly described.

  13. The Gemini Planet Imager Coronagraph Testbed Preliminary Performance Results

    NASA Astrophysics Data System (ADS)

    Roberts, Robin

    2010-01-01

    The Gemini Planet Imager (GPI) is a new science instrument being developed and slated for first light early 2011 on the twin 8m Gemini telescopes. Operating in the near infrared, this ground-based, extreme Adaptive Optics (ExAO) coronographic instrument will provide the ability to detect, characterize and analyze young (< 2GYr), self-luminous, extrasolar planets with brightness contrast ratios ≤ 10-7 when compared to their parent star. The coronagraph subsystem includes a pupil apodization, a hard-edged focal plane mask as well as a Lyot stop. Preliminary results indicate that the testbed is performing at very high contrast, having achieved broadband contrasts (H-band) below 10-6 at separations > 5λ/D. Fraunhoffer and Fresnel propagation modeling were used to analyze the testbed results.

  14. Multi-GNSS Orbit and Clock Combination: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fritsche, Mathias

    2016-04-01

    In the framework of the Multi-GNSS Experiment (MGEX) a number of Analysis Centers (ACs) extended their software capabilities to process signals from the BeiDou, Galileo, and QZSS systems in addition to the well established systems GPS and GLONASS. Currently, the MGEX product portfolio covers precise satellite orbits and clocks, receiver clocks, signal biases, and Earth rotation parameters generated by the individual ACs. This presentation will provide an overview on the available AC-specific MGEX products. In addition, an introduction to a multi-GNSS orbit and clock combination procedure will be given. Finally, preliminary results from that multi-GNSS combination including a comparison with corresponding operational IGS products will be reported along with a discussion of the results.

  15. Preliminary results on two-dimensional interferometry of HL Tau

    NASA Technical Reports Server (NTRS)

    Tollestrup, Eric V.; Harvey, Paul M.

    1989-01-01

    Preliminary two-dimensional speckle interferometry results of HL Tau were found to be qualitatively similar to those found with one-dimensional slit scanning techniques; results consist of a resolved component (approximately 0.7 arcsec in size) and an unresolved component. Researchers are currently reducing the rest of the data (taken on three different telescopes and at three different wavelengths) and are also exploring other high resolution methods like the shift and add technique and selecting only the very best images for processing. The availability of even better two-dimensional arrays within the next couple of years promises to make speckle interferometry and other high resolution techniques very powerful and exiting tools for probing a variety of objects in the subarcsec regime.

  16. Windblown sand on Venus - Preliminary results of laboratory simulations

    NASA Technical Reports Server (NTRS)

    Greeley, R.; Iversen, J.; Leach, R.; Marshall, J.; Williams, S.; White, B.

    1984-01-01

    Small particles and winds of sufficient strength to move them have been detected from Venera and Pioneer-Venus data and suggest the existence of aeolian processes on Venus. The Venus wind tunnel (VWT) was fabricated in order to investigate the behavior of windblown particles in a simulated Venusian environment. Preliminary results show that sand-size material is readily entrained at the wind speeds detected on Venus and that saltating grains achieve velocities closely matching those of the wind. Measurements of saltation threshold and particle flux for various particle sizes have been compared with theoretical models which were developed by extrapolation of findings from Martian and terrestrial simulations. Results are in general agreement with theory, although certain discrepancies are apparent which may be attributed to experimental and/or theoretical-modeling procedures. Present findings enable a better understanding of Venusian surface processes and suggest that aeolian processes are important in the geological evolution of Venus.

  17. Preliminary results from Radiation Environment Investigations on GIOVE-A

    NASA Astrophysics Data System (ADS)

    Underwood, C. I.; Taylor, B.; Ryden, K. A.; Rodgers, D. J.; Dyer, C. S.; Evans, H. D. R.; Daly, E. J.

    GIOVE-A is a small satellite build by SSTL UK for the European Space Agency as a first element of its Galileo satellite navigation programme GIOVE-A s primary payload is a navigation payload to secure use of the frequencies allocated by the International Telecommunications Union ITU for the Galileo system and to demonstrate critical technologies for the navigation payload of future operational Galileo satellites It also includes radiation environments and effects experiments constructed by the University of Surrey CEDEX and QinetiQ MERLIN to characterise the hazardous MEO environment GIOVE-A was launched 28 December 2005 into a 24000 km circular orbit with 56 degree inclination The environment experiments contain detectors to register the electron proton and ion signals and also to investigate the resulting total dose and charging environments The payloads will be described and preliminary results will be presented

  18. Preliminary Results from Galaxy Zoo: The Sloan by Eye

    NASA Astrophysics Data System (ADS)

    Lintott, Chris; Schawinski, K.; Land, K.; Slosar, A.; Szalay, A.; Bamford, S.; Nichol, R.; Thomas, D.; van den Berg, J.; Murray, P.; Raddick, J.; Andreescu, D.; Galaxy Zoo Team

    2007-12-01

    The relationship between the morphology of a galaxy and its formation and evolution is a fundamental question for modern astrophysics. However, classification by morphology is still most reliably performed by visual inspection of the data, and so in the era of large redshift surveys it is normal to estimate morphology via proxies for galaxy shape such as colour or the density profile (e.g. Bernardi et al. 2003). The use of such proxies must introduce a bias into the result (See Schawinski et al. 2007). In this presentation we present the first scientific results of the Galaxy Zoo project, which invited the public to inspect and classify galaxies drawn from the Sloan Digital Sky Survey (SDSS). (Our methodology is described in an accompanying outreach poster) More than 110,000 people have viewed more than 30 million images, leading to a catalogue of more than 300,000 galaxies with secure classifications. A comparison with smaller catalogues produced by professional astronomers (e.g. Fukugita et al. 2007) is used to demonstrate the accuracy of Galaxy Zoo classifications. One obvious advantage of our approach is the identification of galaxies that appear morphologically normal, but are otherwise unusual. As an example, we present preliminary results from a study of extremely blue early-type galaxies identified by the project. We also derive for the first time a low-redshift morphology-density relation which is based on visual morphologies, covering an unprecedented range of environments across the whole SDSS. In addition to galaxy morphology, classifiers were also asked to identify the sense of rotation of spiral galaxies; we present preliminary results providing a test of the cosmological principle, as well as constraints on the tidal torque theory of structure formation.

  19. Implications of Scheduled ITC Reversion for RPS Compliance: Preliminary Results

    SciTech Connect

    Lowder, Travis; Miller, John; O'Shaughnessy, Eric; Heeter, Jenny

    2015-09-14

    This poster presents DRAFT initial results of a forthcoming NREL analysis. The analysis investigates the impacts of the scheduled investment tax credit (ITC) reversion from 30 percent to 10 percent for certain solar photovoltaic projects. Specifically, it considers whether the reversion will result in increased use of alternative compliance payments (ACPs) in lieu of solar renewable energy credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015. credits (SRECs) for renewable portfolio standard (RPS) compliance. The analysis models the effect of a 10 percent ITC on power purchase agreement (PPA) prices for non-residential systems in the eight states with solar carve-outs and solar ACPs. Our preliminary results suggest that states will likely install sufficient capacity to meet long-term targets through SRECs rather than ACPs following the ITC reversion. However, the analysis shows that the ITC reversion could affect project economics such that capacity shortfalls in certain states could temporarily increase the use of ACPs. NREL anticipates publishing a full report of this analysis in fall 2015.

  20. 78 FR 34340 - Welded Carbon Steel Standard Pipe and Tube Products From Turkey: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... did not. The preliminary results are listed below in the section titled ``Preliminary Results of... produced by Borusan and Erbosan for which these companies did not know that the merchandise was destined...

  1. Preliminary results of non-contact THz imaging of cornea

    NASA Astrophysics Data System (ADS)

    Sung, Shijun; Garritano, James; Bajwa, Neha; Deng, Sophie; Hubschman, Jean-Pierre; Grundfest, Warren S.; Taylor, Zachary D.

    2015-03-01

    This paper presents a novel THz optical design that allows the acquisition of THz reflectivity maps of in vivo cornea without the need for a field flattening window and preliminary imaging results of in vivo rabbit cornea. The system's intended use is to sense small changes in corneal tissue water content (CTWC) that can be precursors for a host of diseases and pathologies. Unique beam optics allows the scanning of a curved surface at normal incidence while keeping the source detector and target stationary. Basic system design principles are discussed and image sets of spherical calibration targets and corneal phantom models are presented. The presented design will enable, for the first time, non-contact THz imaging of animal and human cornea.

  2. Synthetic Light Curves for Born Again Events: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Miller Bertolami, M. M.; Rohrmann, R. D.

    2013-01-01

    The development of surveys which will be able to cover a large region of the sky several times per year will allow the massive detection of transient events taking place on timescales of years. In addition, the projected full digitalization of the Harvard plate collection will open a new window on the identification of slow transients taking place on timescales of centuries. In particular, these projects will allow the detection of stars undergoing slow eruptions as those expected during late helium flashes in the post-AGB evolution. In order to identify those transients which correspond with late helium flashes the development of synthetic light curves of those events is mandatory. In this connection we present preliminary results of a project aimed at computing grids of theoretical light curves of born again stars.

  3. The Southern HII Region Discovery Survey: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Shea, Jeanine; Wenger, Trey; Balser, Dana S.; Anderson, Loren D.; Armentrout, William P.; Bania, Thomas M.; Dawson, Joanne; Miller Dickey, John; Jordan, Christopher; McClure-Griffiths, Naomi M.

    2017-01-01

    HII regions are some of the brightest sources at radio frequencies in the Milky Way and are the sites of massive O and B-type star formation. They have relatively short (< 10 Myr) lifetimes compared to other Galactic objects and therefore reveal information about spiral structure and the chemical evolution of the Galaxy. The HII Region Discovery Surveys (HRDS) discovered about 800 new HII regions in the Galactic longitude range -20 degrees to 270 degrees using primarily the Green Bank Telescope. Candidate HII regions were selected from mid-infrared emission coincident with radio continuum emission, and confirmed as HII regions by the detection of radio recombination lines. Here we discuss the Southern HII Region Discovery Survey (SHRDS), a continuation of the HRDS using the Australia Telescope Compact Array over the Galactic longitude range 230 to 360 degrees. We have reduced and analyzed a small sub-set of the SHRDS sources and discuss preliminary results, including kinematic distances and metallicities.

  4. Preliminary results and future activities at the GARFIELD apparatus

    NASA Astrophysics Data System (ADS)

    Gramegna, F.; Mastinu, P. F.; Vannucci, L.; Bruno, M.; D'Agostino, M.; Fiandri, L.; Lanchais, A.; Vannini, G.; Casini, G.; Chiari, M.; Nannini, A.; Bonasera, A.; Cavallaro, S.; Cosmano, A.; Moroni, A.; Ordine, A.; Abbondanno, U.; Milazzo, P. M.; Margagliotti, G. M.

    2002-01-01

    A new apparatus has been designed and built to study reaction mechanisms in the energy regime of the ALPI linear accelerator of the Laboratori Nazionali di Legnaro (E/A = 5 - 20 MeV). In this paper the importance of studying these mechanisms will be underlined, no more as a problem limited to a narrow energy range or a single process, but as a continuous trend from low to high energies and from the physics of stable nuclei to that one regarding instabilities. With this remarks in mind, a first experiment has been performed studying the reaction 32S+58Ni at 11AMeV. Preliminary results show that important information can be derived on multi-body emission, which can contribute to renew the interest in this energy regime.

  5. Preliminary Results From the First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Adams, James H., Jr.; Ahn, H.; Ampe, J.; Bashindzhagyan, G.; Case, G.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition C and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the protons and C helium spectra will be reported in this paper.

  6. Preliminary Results From The First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the proton and helium spectra will be reported in this paper.

  7. Aconcagua peak geodynamics from GPS observations, Mendoza, Argentina: preliminary results

    NASA Astrophysics Data System (ADS)

    Mateo, M. L.; Lenzano, L. E.; Moreiras, S. M.

    2009-12-01

    In 2005, the SIGMA Program (Mount Aconcagua GNSS Research System) was implemented to investigate the geodynamics of the Aconcagua mountain region in the Central Andes. For this purpose, a continuously recording GPS station, ACON, was installed on the summit of Mount Aconcagua at 6.292 m a.s.l. The installation required special technology to support the equipment under extreme climatic conditions. The power supply system was optimized in 2008, so that a greater quantity of data could be recorded. This, in turn, will lead to more accurate estimates of displacement of the Aconcagua peak. Preliminary results from the ACON station indicate an average horizontal velocity of 0.023±0.0001 m/yr toward NE in 2 time windows between 2006 and 2008.

  8. Ex vivo accommodation simulator II: concept and preliminary results

    NASA Astrophysics Data System (ADS)

    Ehrmann, Klaus; Ho, Arthur; Parel, Jean-Marie

    2004-07-01

    A new instrument was developed to simulate the accommodation of excised human and animal crystalline lenses. The sclera is attached to 8 radially arranged translation stages and dissected into 8 segments. Change in accommodation is simulated by pulling and releasing the scleral segments, varying the load on the zonules and the capsular bag. Each translation stage is equipped with a sensitive force transducer for simultaneous recording of load and displacement. Additionally, changes in optical power, lens diameter, lens thickness and lens shape can be observed and quantified while the lens is stretched and released. The sensitivity and accuracy of the instrument was verified using steel springs and elastic bands. Preliminary results from sensitivity testing and instrument calibration are presented.

  9. Preliminary Results From The First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the proton and helium spectra will be reported in this paper.

  10. Preliminary Results From the First Flight of ATIC

    NASA Technical Reports Server (NTRS)

    Seo, E. S.; Adams, James H., Jr.; Ahn, H.; Ampe, J.; Bashindzhagyan, G.; Case, G.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    The Advanced Thin Ionization Calorimeter (ATIC) instrument is designed to measure the composition C and energy spectra of Z = 1 to 28 cosmic rays over the energy range approximately 10 GeV - 100 TeV. The instrument was calibrated in September 1999 at CERN using accelerated electron, proton and pion beams. ATIC was launched as a long duration balloon test flight on 12/28/00 local time from McMurdo, Antarctica. After flying successfully for about 16 days the payload was recovered in excellent condition. Absolute calibration of the detector response was made using cosmic-ray muons. The data analysis algorithm which was developed with Monte Carlo simulations and validated with the CERN beam test will be used for the flight data analysis. Preliminary results of the protons and C helium spectra will be reported in this paper.

  11. Charge breeder for the SPIRAL1 upgrade: Preliminary results

    SciTech Connect

    Maunoury, L. Delahaye, P.; Dubois, M.; Bajeat, O.; Frigot, R.; Jeanne, A.; Jardin, P.; Kamalou, O.; Lecomte, P.; Osmond, B.; Peschard, G.; Savalle, A.; Angot, J.; Sole, P.; Lamy, T.

    2016-02-15

    In the framework of the SPIRAL1 upgrade under progress at the GANIL lab, the charge breeder based on a LPSC Phoenix ECRIS, first tested at ISOLDE has been modified to benefit of the last enhancements of this device from the 1+/n+ community. The modifications mainly concern the 1 + optics, vacuum techniques, and the RF—buffer gas injection into the charge breeder. Prior to its installation in the midst of the low energy beam line of the SPIRAL1 facility, it has been decided to qualify its performances and several operation modes at the test bench of LPSC lab. This contribution shall present preliminary results of experiments conducted at LPSC concerning the 1 + to n+ conversion efficiencies for noble gases as well as for alkali elements and the corresponding transformation times.

  12. Preliminary medical results of the Mir year-long mission

    NASA Astrophysics Data System (ADS)

    Grigoriev, A. I.; Bugrov, S. A.; Bogomolov, V. V.; Egorov, A. D.; Kozlovskaya, I. B.; Pestov, I. D.; Polyakov, V. V.; Tarasov, I. K.

    The basic goal of medical investigations during and after the 366-day mission was to accumulate data about physiological responses to such a long exposure to microgravity. In flight, cardiovascular and other systems were examined in detail and the efficacy of countermeasures used was assessed. After flight, physiological systems were also followed very carefully. According to the preliminary data, the medical results obtained during and after flight give evidence that man can well adapt to a year-long space flight, maintaining good health and adequate work capacity. The readaptation process was very similar to that observed after shorter flights (6-II months). As compared to former flights, no new or qualitatively different changes in the vital systems of the body were seen. The observations indicate that the duration of manned space missions can be further increased.

  13. Preliminary Results from the Second EUVE Right Angle Program Catalog

    NASA Astrophysics Data System (ADS)

    Christian, D. J.; Craig, N.; Cahill, W. D.; Roberts, B.; Malina, R. F.

    1997-12-01

    We present preliminary results of our search for new sources in the EUVE Right Angle Program (RAP) data. The EUVE all-sky survey telescopes (also known as ``scanners'') are mounted at right angles to the Deep Survey and spectrometer instruments, and obtain photometric data in four bands centered at ~ 100 Angstroms (Lexan/B), ~ 200 Angstroms (Al/Ti/C), ~ 400 Angstroms (Ti/Sb/Al), and ~ 550 Angstroms (Sn/SiO). This allows the Right Angle Program to accumulate data serendipitously during pointed spectroscopic observations. The long exposure times possible with RAP observations provide much greater sensitivity than the all-sky survey. One-half of the scanner data since January 1994 has been analyzed, yielding approximately 200 new source detections. We present light-curves and variability measurements for the brighter sources. We have detected stellar flares from several yet to be identified sources. Source identifications and distribution by type will be also be presented.

  14. Preliminary Test Results for the MICE Spectrometer Superconducting Solenoids

    SciTech Connect

    Virostek, Steve P.; Green, Michael A; Li, Derun; Zisman, Michael S.; Wang, S.T.; Wahrer, R.; Taylor, Clyde; Lu, X.; Chen, J. Y.; Wang, Mimi; Juang, Tiki

    2008-08-02

    This report describes the MICE spectrometer solenoids as built. Each magnet consists of five superconducting coils. Two coils are used to tune the beam going from or to the MICE spectrometer from the rest of the MICE cooling channel. Three spectrometer coils (two end coils and a long center coil) are used to create a uniform 4 T field (to {+-}0.3 percent) over a length of 1.0 m within a diameter of 0.3 m. The three-coil spectrometer set is connected in series. The two end coils use small power supplies to tune the uniform field region where the scintillating fiber tracker is located. This paper will present the results of the preliminary testing of the first spectrometer solenoid.

  15. RF tomography of metallic objects in free space: preliminary results

    NASA Astrophysics Data System (ADS)

    Li, Jia; Ewing, Robert L.; Berdanier, Charles; Baker, Christopher

    2015-05-01

    RF tomography has great potential in defense and homeland security applications. A distributed sensing research facility is under development at Air Force Research Lab. To develop a RF tomographic imaging system for the facility, preliminary experiments have been performed in an indoor range with 12 radar sensors distributed on a circle of 3m radius. Ultra-wideband pulses are used to illuminate single and multiple metallic targets. The echoes received by distributed sensors were processed and combined for tomography reconstruction. Traditional matched filter algorithm and truncated singular value decomposition (SVD) algorithm are compared in terms of their complexity, accuracy, and suitability for distributed processing. A new algorithm is proposed for shape reconstruction, which jointly estimates the object boundary and scatter points on the waveform's propagation path. The results show that the new algorithm allows accurate reconstruction of object shape, which is not available through the matched filter and truncated SVD algorithms.

  16. MEMS-based microgratings: preliminary results of novel configurations

    NASA Astrophysics Data System (ADS)

    Castracane, James; Gutin, Mikhail A.

    1998-03-01

    The advent of micromachining has opened new doors for reducing the size and weight of conventional systems. A significant example is in the area of optics in which the size reduction can be exploited to produce ultra-miniature systems using MEMS device as the sensing or control elements. Using MEMS-based fabrication methods (the MUMPS runs), a series of optical diffraction gratings has been produced to examine limitations on the production methods and explore alternative applications. These devices consist of a variety of structures including single gratings, arrays of gratings and multi-periodic gratings. These devices are based on 3D architectures which can be adjusted in real time using electrostatic attraction from custom segmented electrode structures. The gratings were released and packaged for laboratory tests. Selected packaged devices were equipped with windows and integrated into a compact spectrograph to document spectral quality and performance. Preliminary results of mechanical, optical and electrical tests will be discussed.

  17. Breast ultrasound tomography with two parallel transducer arrays: preliminary clinical results

    NASA Astrophysics Data System (ADS)

    Huang, Lianjie; Shin, Junseob; Chen, Ting; Lin, Youzuo; Intrator, Miranda; Hanson, Kenneth; Epstein, Katherine; Sandoval, Daniel; Williamson, Michael

    2015-03-01

    Ultrasound tomography has great potential to provide quantitative estimations of physical properties of breast tumors for accurate characterization of breast cancer. We design and manufacture a new synthetic-aperture breast ultrasound tomography system with two parallel transducer arrays. The distance of these two transducer arrays is adjustable for scanning breasts with different sizes. The ultrasound transducer arrays are translated vertically to scan the entire breast slice by slice and acquires ultrasound transmission and reflection data for whole-breast ultrasound imaging and tomographic reconstructions. We use the system to acquire patient data at the University of New Mexico Hospital for clinical studies. We present some preliminary imaging results of in vivo patient ultrasound data. Our preliminary clinical imaging results show promising of our breast ultrasound tomography system with two parallel transducer arrays for breast cancer imaging and characterization.

  18. Smart isolation mount for army guns: I. Preliminary results

    NASA Astrophysics Data System (ADS)

    Allaei, Daryoush; Tarnowski, David J.; Mattice, Michael S.; Testa, Robert C.

    2000-06-01

    The work reported in this paper is focused on an effective and efficient solution, namely Smart Isolation Mount for Army Guns (SIMAG), to the weapon stabilization and fire control issues facing US Army guns. SIMAG is composed of the optimum integration of two innovative technologies. Vibration Control by Confinement and smart senor/actuator/active control systems. The combined approach may also be applied to a gun barrel to reduce its undesired vibratory motions excited by external and internal disturbances, such as gun firing action. SIMAG reconfigures the distribution and propagation of excess vibration energy and confines vibrations to certain non-critical regions or modes within a structure. Concentrated passive, active, or smart damping elements or cancellation techniques may be applied to more effectively dissipate or cancel the trapped vibrations and to prevent build up in the assembly. As the active elements, an array of collocated, PZT-based sensor- actuator sets is recommended for incorporation in SIMAG. Part of the active elements is used for spatially managing excess vibration energy while the other part is utilized for energy dissipation and cancellation. The preliminary result of our feasibility work on the SIMAG concept is demonstrated via computer simulations. It is shown that the insertion of a preliminary version of SIMAG in a 30mm gun system onboard an attack helicopter reduces the fluctuating loads and deformations measured across the helicopter bottom shell by 40 to 50 percent. SIMAG makes significant progress towards solving the firing control problems with affordable weight and power penalties by compensating for all errors in one of the two places, the turret-aircraft interface or gun barrel. Even thought the initial target application of SIMAG is airborne guns, a modified version can be incorporated into ground armors, such as tanks and humvees.

  19. [Colorectal cancer screening programme in Aragon (Spain): preliminary results].

    PubMed

    Solé Llop, Mª Esther; Cano Del Pozo, Mabel; García Montero, José-Ignacio; Carrera-Lasfuentes, Patricia; Lanas, Ángel

    2017-08-04

    To describe preliminary findings from the colorectal cancer screening programme in Aragon (Spain) to evaluate its implementation. We have collected data from the first year of the program (2014) based on faecal occult blood immunochemical (FOBTi) test in patients 60-69 years old. We report "indicators" defined by the "Red Nacional de Cribado". Invited population after exclusions: 12,518. Program participation rate: 45.28% (95%CI: 44.41-46.15). Inadequate tests: 0.21% (95%CI: 0.12-0.37); positive FOBTi test 10.75% (95%CI: 9.97-11.58) and colonoscopy acceptance 95.07% (95%CI: 93.04-96.52). Colonoscopy was appropriate and complete in 97.58% (95%CI: 95.98-98.55) of cases. The high- and low-risk adenoma detection rates were 14.7‰ (95%CI: 11.9-18.2) and 5.55‰ (95%CI: 3.9-7.8) respectively. The positive predictive value for any adenoma was 58.55% (95%CI: 54.49-62.49) and for invasive cancer was 5.36% (95%CI: 3.8-7.51). The indicator analysis of the ongoing programme suggests the programme is being implemented correctly in our community. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Benchmarking the Integration of WAVEWATCH III Results into HAZUS-MH: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Berglund, Judith; Holland, Donald; McKellip, Rodney; Sciaudone, Jeff; Vickery, Peter; Wang, Zhanxian; Ying, Ken

    2005-01-01

    The report summarizes the results from the preliminary benchmarking activities associated with the use of WAVEWATCH III (WW3) results in the HAZUS-MH MR1 flood module. Project partner Applied Research Associates (ARA) is integrating the WW3 model into HAZUS. The current version of HAZUS-MH predicts loss estimates from hurricane-related coastal flooding by using values of surge only. Using WW3, wave setup can be included with surge. Loss estimates resulting from the use of surge-only and surge-plus-wave-setup were compared. This benchmarking study is preliminary because the HAZUS-MH MR1 flood module was under development at the time of the study. In addition, WW3 is not scheduled to be fully integrated with HAZUS-MH and available for public release until 2008.

  1. 76 FR 79655 - Honey From Argentina: Notice of Extension of Time Limit for Preliminary Results

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-22

    ... International Trade Administration Honey From Argentina: Notice of Extension of Time Limit for Preliminary... September 7, 2011, the Department extended the time limit for the preliminary results until December 1, 2011...) Seabird Argentina S.A. See Notice of Extension of Time Limit for Preliminary Results and Partial...

  2. 76 FR 76374 - Honey From Argentina: Notice of Extension of Time Limit for Preliminary Results

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-07

    ... International Trade Administration Honey From Argentina: Notice of Extension of Time Limit for Preliminary... September 7, 2011, the Department extended the time limit for the preliminary results until December ] 1... (10) Seabird Argentina S.A. See Notice of Extension of Time Limit for Preliminary Results and Partial...

  3. Sand transport on Mars: Preliminary results from models

    NASA Technical Reports Server (NTRS)

    Greeley, R.; Anderson, F. S.; Blumberg, D.; Lo, E.; Xu, P.; Pollack, J.

    1993-01-01

    Most studies of active aeolian processes on Mars have focused on dust, i.e., particles approximately 1 micron in diameter that are transported in suspension by wind. The presence of sand dunes on Mars indicates that larger grains (approximately greater than 60 microns, transported primarily in saltation) are also present. Although indirect evidence suggests that some dunes may be active, definitive evidence is lacking. Nonetheless, numerous studies demonstrate that sand is substantially easier to transport by wind than dust, and it is reasonable to infer that sand transportation in saltation occurs under present Martian conditions. In order to assess potential source regions, transportation pathways, and sites of deposition for sand on Mars, an iterative sand transport algorithm was developed that is based on the Mars General Circulation Model of Pollack et al. The results of the dust transport model are then compared with observed surface features, such as dune field locations observed on images, and surficial deposits as inferred from Viking IRTM observations. Preliminary results suggest that the north polar dune fields in the vicinity of 270 degrees W, 70 degrees N originated from weathered polar layered plains centered at 280 degrees W, 85 degrees N, and that Thaumasia Fossae, southern Hellas Planitia, and the area west of Hellespontus Montes are sand depositional sites. Examples of transportation 'corridors' include a westward pathway in the latitudinal band 35 degrees N to 45 degrees N, and a pathway southward from Solis Planum to Thaumasia Fossae, among others.

  4. The Myres Hill remote sensing intercomparison study: preliminary results

    NASA Astrophysics Data System (ADS)

    Clive, P. J. M.; Chindurza, I.; Ravey, I.; Bass, J.; Boyle, R. J.; Jones, P.; Lang, S. J.; Bradley, S.; Hay, L.; Oldroyd, A.; Stickland, M.

    2008-05-01

    Two remote sensing techniques (SODAR and LIDAR) have been developed for measuring wind speed and turbulence from ground level up to altitudes of 300 m or higher. Although originally developed in the defence sector, these techniques are now generating considerable interest in the renewable energy and meteorological sectors. Despite the benefits of these instruments they are not yet generally accepted for due diligence measurements by wind energy developers and financial institutions. There is a requirement for a series of independent assessments of these new metrology techniques, comparing their measurements with the approved cup-type anemometer readings. This is being addressed at TUV NEL's Myres Hill wind turbine test site in a measurement programme supported by the DIUS National Measurement Systems Measurement for Innovators scheme and a consortium of 21 industrial collaborators. Data from SODAR and LIDAR systems are being compared with results from cup-type anemometers mounted at different heights on an 80m meteorological mast. An ultrasonic sensor is also mounted on the mast. The objective of the test programme is to assess the effectiveness of SODAR and LIDAR wind speed measurement techniques under different operating regimes and atmospheric conditions. Results from the measurements will provide definitive data on the performance of the remote wind speed sensing techniques under test on complex terrain typical of many wind farm sites. Preliminary measurements based on data acquired during the initial measurement campaign are presented.

  5. Preliminary Results of ICRH on the RT-1 Magnetospheric Device

    NASA Astrophysics Data System (ADS)

    Yano, Yoshihisa; Saitoh, Haruhiko; Yoshida, Zensho; Morikawa, Junji; Fukuyama, Atsushi

    2011-10-01

    The Ring Trap-1 device, which uses a levitating super-conducting magnet, has already achieved a stable confinement of high-beta plasma (βlocal > 0 . 7) by using ECRH(Electron Cyclotron Resonance Heating). Now we are aiming to heat ions by the use of ICRH(Ion Cyclotron Resonance Heating) as a next phase of the RT-1 experiment. In the dipole configuration, the magnetic field strength (0.01-0.5 T) and the plasma density (ne ~1017m-3) are lower than in other plasma confinement devices. These features of the dipole plasma may generally result in low plasma loading impedance. Therefore we experimentally examined the loading impedance by the resonance method. In the experiment, a test antenna (φ260-300, 3 turns) was installed around the RT-1 center-stack (φ180). The RF frequency was 1 - 3 MHz and the RF input power was less than 200 mW. The observed loading impedance became higher when the RF frequency and the plasma density were increased. The maximum observed impedance was 17 Ω at 3 MHz and 0.6 Ω at 1 MHz. These dependences on the RF frequency and the plasma density agree with the preliminary calculation results. The detailed comparison between experiment and calculation will be presented.

  6. Design, integration and preliminary results of the IXV Catalysis experiment

    NASA Astrophysics Data System (ADS)

    Viladegut, Alan; Panerai, F.; Chazot, O.; Pichon, T.; Bertrand, P.; Verdy, C.; Coddet, C.

    2017-06-01

    The CATalytic Experiment (CATE) is an in-flight demonstration of catalysis effects at the surface of thermal protection materials. A high-catalytic coating was applied over the baseline ceramic material on the windward side of the intermediate experimental vehicle (IXV). The temperature jump due to different catalytic activities was detected during re-entry through measurements made with near-surface thermocouples on the windward side of the vehicle. The experiment aimed at contributing to the development and validation of gas/surface interaction models for re-entry applications. The present paper summarizes the design of CATE and its integration on the windward side of the IXV. Results of a qualification campaign at the Plasmatron facility of the von Karman Institute for Fluid Dynamics are presented. They provided an experimental evidence of the temperature jump at the low-to-high catalytic interface of the heat shield under aerothermal conditions relevant to the actual IXV flight. These tests also gave confidence so that the high-catalytic patch would not endanger the integrity of the vehicle and the safety of the mission. A preliminary assessment of flight data from the thermocouple measurements shows consistency with results of the qualification tests.

  7. The GABLS4 Inter-comparison: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Bazile, E.; Couvreux, F.; Le Moigne, P.

    2015-12-01

    The GABLS4 intercomparison, launched in summer 2014, aims to study the interaction between the boundary layer and the surface in strong stability and during the diurnal transition focussing on the decrease of the turbulence. For this, the observation site of Dome C on the Antarctic Plateau was chosen mainly for two reasons: the availability of the in-situ measurements from a 45-m tower and a homogeneous surface with a low conductivity such as snow on a flat topography. The intercomparison will consist of 3 inter-comparisons : Single Column Model (SCM), Large Eddy Simulation (LES) and land-snow model (LSM). It is organized in two steps. The first one is dedicated to the LSM and the SCM with an interactive surface (snow) scheme. Then, in the second one, the observed surface temperature will be prescribed in the SCM and in the LES models. The first GABLS4 workshop was organized in May 2015 in Toulouse (France). 12 groups with LSM/SCM and 7 for LES/DNS sent already the simulations. After a brief description of the setup, the main results for the SCM intercomparison with observations and some preliminary results from the LES will be presented. The setup and more details are available on the GABLS4 Web page (http://www.cnrm.meteo.fr/aladin/meshtml/GABLS4/GABLS4.html).

  8. Design, integration and preliminary results of the IXV Catalysis experiment

    NASA Astrophysics Data System (ADS)

    Viladegut, Alan; Panerai, F.; Chazot, O.; Pichon, T.; Bertrand, P.; Verdy, C.; Coddet, C.

    2016-08-01

    The CATalytic Experiment (CATE) is an in-flight demonstration of catalysis effects at the surface of thermal protection materials. A high-catalytic coating was applied over the baseline ceramic material on the windward side of the intermediate experimental vehicle (IXV). The temperature jump due to different catalytic activities was detected during re-entry through measurements made with near-surface thermocouples on the windward side of the vehicle. The experiment aimed at contributing to the development and validation of gas/surface interaction models for re-entry applications. The present paper summarizes the design of CATE and its integration on the windward side of the IXV. Results of a qualification campaign at the Plasmatron facility of the von Karman Institute for Fluid Dynamics are presented. They provided an experimental evidence of the temperature jump at the low-to-high catalytic interface of the heat shield under aerothermal conditions relevant to the actual IXV flight. These tests also gave confidence so that the high-catalytic patch would not endanger the integrity of the vehicle and the safety of the mission. A preliminary assessment of flight data from the thermocouple measurements shows consistency with results of the qualification tests.

  9. The Northrop Grumman External Occulter Testbed: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Lo, Amy; Glassman, T.; Lillie, C.

    2007-05-01

    We have built a subscale testbed to demonstrate and validate the performance of the New Worlds Observer (NWO), a terrestrial planet finder external-occulter mission concept. The external occulter concept allows observations of nearby exo-Earths using two spacecraft: one carrying an occulter that is tens of meters in diameter and the other carrying a generic space telescope. The occulter is completely opaque, resembling a flower, with petals having a hypergaussian profile that enable 10-10 intensity suppression of stars that potentially harbor terrestrial planets. The baseline flight NWO system has a 30 meter occulter flying 30,000 km in front of a 4 meter class telescope. Testing the flight configuration on the ground is not feasible, so we have matched the Fresnel number of the flight configuration ( 10) using a subscale occulter. Our testbed consists of an 80 meter length evacuated tube, with a high precision occulter in the center of the tube. The occulter is 4 cm in diameter, manufactured with ¼ micron metrological accuracy and less than 2 micron tip truncation. This mimics a 30 meter occulter with millimeter figure accuracy and less than centimeter tip truncation. Our testbed is an evolving experiment, and we report here the first, preliminary, results using a single wavelength laser (532 nm) as the source.

  10. Calibration Study and Preliminary Results of PRad Experiment

    NASA Astrophysics Data System (ADS)

    Levillain, Maxime; PRad Collaboration

    2016-09-01

    The latest measurements of the proton radius through muonic hydrogen Lamb shift show a discrepancy of 7 σ from a global analysis of standard hydrogen Lamb shift and elastic ep -scattering. In order to understand this proton radius puzzle, the PRad experiment successfully took in last June some elastic ep -scattering data at very low Q2 (2 .10-4 to 10-1 GeV2) with very accurate angle and energy measurements to minimize the systematic uncertainties. Before measuring the cross-sections that will be used to extract the electromagnetic form factor GE(Q2) and the proton radius, a very careful calibration of the electromagnetic calorimeter (HyCal) must be performed to get a good energy resolution and separate ep -events from M øller events especially at low angle. We will present an extended study of the electromagnetic calorimeter calibration of this experiment as well as some preliminary results on ep - and ee -scattering processes extracted from the data. The PRad experiment is supported in part by NSF MRI Award PHY-1229153.

  11. Laboratory study of corrosion of steam generator tubes: Preliminary results

    SciTech Connect

    Sala, B.; Organista, M.; Henry, K.; Erre, R.; Gelpi, A.; Cattant, F.; Dupin, M.

    1995-12-31

    The secondary side intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) of steam generator tubes often occurs in crevices where impurities are concentrated, due to local elevated temperatures and restricted water flow. From the analysis of tubes pulled from plants, it is believed that alumino-silicates deposits and/or organic species may play a role in the development of IGA in near neutral environments. New observations suggest that similar environments and similar processes are operative inside the corroded grain boundaries. A former study using autoclave tests was mainly devoted to the formation of alumino-silicate deposits similar to those observed in plants. The present work pursued the study of local environments responsible for IGA/SC. It confirms former results on the catalytic decomposition of organic species into acetates and presents more details on the mechanism of formation of alumino-silicate deposits on alloy 600, particularly on the role of iron and, to a lesser extent, nickel cations. It was showed that, under the alumino-silicate deposits and in the presence of some organic species, a non-protective chromium rich layer may grow instead of the usual protective spinel oxide. The mechanism responsible for the formation of this layer is believed to involve interaction between iron and, to a lesser extent, nickel with silica and/or possible interaction between chromium and acetates. Preliminary capsule tests indicate that these conditions may induce the initiation of IGA.

  12. SWCX Emission from the Helium Focusing Cone - Preliminary Results

    NASA Technical Reports Server (NTRS)

    Snowden, S. L.; Kuntz, K. D.; Collier, M. R.

    2008-01-01

    Preliminary results from an XMM-Newton campaign to study solar wind charge exchange (SWCX) emission from the heliospheric focusing cone of interstellar helium are presented. The detections of enhanced O VII and O VIII emission from the cone are at the 2(sigma) and 4(sigma) levels. The solar wind charge exchange (SWCX) emission in the heliosphere not associated with distinct objects (e.g., comets and planets including exospheric material in and near Earth s magnetosheath) is proportional to the flux of the solar wind and the space density of neutral material. The neutral material originates in the interstellar medium (ISM) and passes through the solar system due to the relative motion of the Sun and the ISM. The flow of the neutral material through the solar system is strongly perturbed by the Sun both by gravity and by radiation pressure. Because of the relative radiative scattering cross sections and the effect of solar gravitation the density of interstellar hydrogen near the Sun is reduced while interstellar helium is gravitationally focused. This creates a helium focusing cone downstream of the Sun [e.g., 1, and references therein].

  13. Studying the anthropogenic radionuclides in Puerto Rico: Preliminary Result

    NASA Astrophysics Data System (ADS)

    Ithier-Guzmán, W.; Pyrtle, A. J.; Smoak, J.

    2004-12-01

    Local introduction of anthropogenic radionuclides to Puerto Rico's terrestrial and aquatic environments began in 1962 as a result of US government-sponsored research activities. Some of the earlier experiments examined the effects of radiation in tropical rainforests and the potential of superheated boiling nuclear reactor technology. More recent activities involved the use of depleted uranium during military exercises on Vieques. While the presence of radionuclides in Puerto Rico is documented, little research has been done to assess the environmental impact of this anthropogenic material. After entering Puerto Rico's environment, it is likely that some radionuclides are transported away from initial introduction sites. It is important that the distributions and behavior of radionuclides in Puerto Rico be determined. As such an investigation of this material throughout Puerto Rico was initiated. Sediment Cs-137 and Pb-210 activities, as well as ancillary geochemistry data are presented. These preliminary findings will be utilized as part of an ongoing study to determine radionuclide distributions and behaviors, with respect to aquatic geochemistry and dominant transport processes.

  14. Enhancement of perfluoropolyether boundary lubrication performance: I. Preliminary results

    NASA Technical Reports Server (NTRS)

    Jones, W. R., Jr.; Ajayi, O. O.; Goodell, A. J.; Wedeven, L. D.; Devine, E.; Premore, R. E.

    1995-01-01

    A ball bearing simulator operating under starved conditions was used to evaluate the boundary lubrication performance of a perfluoropolyether (PFPE) Krytox 143 AB. Several approaches to enhance boundary lubrication were studied. These included: (1) soluble boundary additives, (2) bearing surface modifications, (3) 'run-in' surface films, and (4) ceramic bearing components. In addition, results were compared with two non-perfluorinated liquid lubricant formulations. Based on these preliminary tests, the following tentative conclusions can be made: (1) substantial improvements in boundary lubrication performance were observed with a beta-diketone boundary additive and a tricresyl phosphate (TCP) liquid surface pretreatment; (2) the use of rough Si3N4 balls (Ra = 40 micro-in) also provided substantial improvement but with concomitant abrasive wear; (3) marginal improvements were seen with two boundary additives (a phosphine and a phosphatriazine) and a neat (100%) fluid (a carboxylic acid terminated PFPE); and surface pretreatments with a synthetic hydrocarbon, a PTFE coating, and TiC coated 440C and smooth Si3N4 balls (R(sub a) less than 1 micro-in); and (4) two non-PFPE lubricant formulations (a PAO and a synthetic hydrocarbon) yielded substantial improvements.

  15. Large co-axial pulse tube preliminary results

    NASA Astrophysics Data System (ADS)

    Emery, N.; Caughley, A.; Meier, J.; Nation, M.; Tanchon, J.; Trollier, T.; Ravex, A.

    2014-01-01

    We report that Callaghan Innovation, formally known as Industrial Research Ltd (IRL), has designed and built its largest of three high frequency single-stage co-axial pulse tubes, closely coupled to a metal diaphragm pressure wave generator (PWG). The previous pulse tube achieved 110 W of cooling power @ 77 K, with an electrical input power of 3.1 kW from a 90 cc swept volume PWG. The pulse tubes have all been tuned to operate at 50 Hz, with a mean helium working pressure of 2.5 MPa. Sage pulse tube simulation software was used to model the latest pulse tube and predicted 280 W of cooling power @ 77 K. The nominal 250 W cryocooler was designed to be an intermediate step to up-scale pulse tube technology for our 1000 cc swept-volume PWG, to provide liquefaction of gases and cooling for HTS applications. Details of the modeling, design, development and preliminary experimental results are discussed.

  16. The Canadian Meteor Orbit Radar: system overview and preliminary results

    NASA Astrophysics Data System (ADS)

    Jones, J.; Brown, P.; Ellis, K. J.; Webster, A. R.; Campbell-Brown, M.; Krzemenski, Z.; Weryk, R. J.

    2005-04-01

    This paper describes the Canadian Meteor Orbit Radar (CMOR) that has been in operation since late 2001. CMOR is a 3 station meteor radar operating at a frequency of 29.85 MHz near Tavistock, Ont. To avoid bias against fragmenting meteoroids that is inherent in the traditional multi-station method of Gill and Davies (Mon. Not. R Astron. Soc. 116 (1955) 105), we use a completely geometrical method similar to that used in the AMOR system (Quart. J. R. Astron. Soc. 35 (1994) 293) based on the interferometric determination of the echo directions and the time delays of echoes from two remote stations to obtain the trajectories and speeds of meteoroids. We describe the hardware and some of the software and present some preliminary results that provide a good indication of present capabilities of the system. Typically, we can measure 1500 individual trajectories, and hence orbits, per day with a mean accuracy of 6° in direction and about 10% in speed. A small subset of these for which it is possible to measure the speeds using Hocking's (Radio. Sci. 35 (2000) 1205) method yield speeds with a precision of about 5%. The purpose of this paper is to show that the radiants and speeds necessary for the computation of orbits are well measured rather than to discuss any orbital surveys.

  17. Auroral Spatial Structures Probe Sub-Orbital Mission Preliminary Results

    NASA Astrophysics Data System (ADS)

    Pratt, J.; Swenson, C.; Martineau, R. J.; Fish, C. S.; Conde, M.; Hampton, D.; Crowley, G.

    2015-12-01

    The NASA Auroral Spatial Structures Probe, 49.002, was launched January 28, 2015 from the Poker Flat Research Range into active aurora over the northern coast of Alaska. The primary objective of this mission was to determine the contribution of small spatial and temporal scale fluctuations of the electric fields to the larger-scale energy deposition processes associated with the aurora. The Auroral Spatial Structures Probe Sub-Orbital Mission consisted of a formation of 7 spacecraft (a main payload with 6 deployable sub-payloads) designed for multiple temporally spaced co-located measurements of electric and magnetic fields in the earth's ionosphere. The mission was able to make observations at a short time scale and small spatial scale convergence that is unobservable by either satellite or ground-based observations. The payloads included magnetometers, electric field double probes, and Langmuir probes as well as a sweeping impedance probe on the main payload. We present here preliminary results from the measurements taken that hint at the underlying spatial structure of the currents and energy deposition in the aurora. The Poynting flux derived from the observations is shown and implications are discussed in terms of the contribution of small spatial scale, rapid temporal scale fluctuations in the currents that deposit energy in the auroral region. Funding provided by NASA Grants NNX11AE23G and NNX13AN20A.

  18. Exploring a Physically Based Tool for Lightning Cessation: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Schultz, Elsie V.; Petersen, Walter A.; Carey, Lawrence D.; Buechler, Dennis E.; Gatlin, Patrick N.

    2010-01-01

    The University of Alabama in Huntsville (UAHuntsville) and NASA s Marshall Space Flight Center are collaborating with the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS) to enable improved nowcasting of lightning cessation. The project centers on use of dual-polarimetric radar capabilities, and in particular, the new C-band dual-polarimetric weather radar acquired by the 45WS. Special emphasis is placed on the development of a physically based operational algorithm to predict lightning cessation. While previous studies have developed statistically based lightning cessation algorithms, we believe that dual-polarimetric radar variables offer the possibility to improve existing algorithms through the inclusion of physically meaningful trends reflecting interactions between in-cloud electric fields and microphysics. Specifically, decades of polarimetric radar research using propagation differential phase has demonstrated the presence of distinct phase and ice crystal alignment signatures in the presence of strong electric fields associated with lightning. One question yet to be addressed is: To what extent can these ice-crystal alignment signatures be used to nowcast the cessation of lightning activity in a given storm? Accordingly, data from the UAHuntsville Advanced Radar for Meteorological and Operational Research (ARMOR) along with the North Alabama Lightning Mapping Array are used in this study to investigate the radar signatures present before and after lightning cessation. A summary of preliminary results will be presented.

  19. This Month in Astronomical History: Preliminary Survey Results

    NASA Astrophysics Data System (ADS)

    Wilson, Teresa

    2017-01-01

    This Month in Astronomical History is a short (~500 word) column on the AAS website that revisits significant astronomical events or the lives of people who have made a large impact on the field. The monthly column began in July 2016 at the request of the Historical Astronomical Division. Examples of topics that have been covered include Comet Shoemaker-Levy’s collision with Jupiter, the discovery of the moons of Mars, the life of Edwin Hubble, Maria Mitchell’s comet discovery, and the launch of Sputnik II. A survey concerning the column is in progress to ensure the column addresses the interests and needs of a broad readership, including historians, educators, research astronomers, and the general public. Eleven questions focus on the style and content of the column, while eight collect simple demographics. The survey has been available on the AAS website since and was mentioned in several AAS newsletters; however, non-members of AAS were also recruited to include respondents from a variety of backgrounds. Preliminary results of the survey are presented and will be used to hone the style and content of the column to serve the widest possible audience. Responses continue to be collected at: https://goo.gl/forms/Lhwl2aWJl2Vkoo7v1

  20. Spitzer IRS Spectra of Basaltic Asteroids: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Lim, Lucy F.; Emery, Joshua P.; Moskovitz, Nick; Stewart, Heather; Marchis, Frank

    2008-01-01

    We present preliminary results of a Spitzer program to observe the 5.2--38 micron spectra of small basaltic asteroids using the Spitzer IRS (Infrared Spectrograph). Our targets include members of the dynamical family of the unique large differentiated asteroid 4 Vesta ("Vestoids"), four outer-main-belt basaltic asteroids whose orbits exclude them from originating on 4 Vesta, and the basaltic near-Earth asteroid (NEA) 4055 Magellan. We will compare the compositions and thermophysical properties of the non-Vestoid objects with those of the dynamical vestoids to provide insight on the extent of metal-silicate differentiation on planetsimals during the epoch of planet formation in the early Solar System. As of this writing, spectra of asteroids 10537 (1991 RY16) and 2763 Jeans have been returned. Analysis of these data are ongolng. Observations of 956 Elisa, 2653 Principia, 4215 Kamo, 7472 Kumakiri, and 1459 Magnya have been scheduled and are expected to be available by the time of the DPS meeting. NIR spectra and lightcurves o f the target asteroids are also being observed in support of this program.

  1. Mapping urban forest tree species using IKONOS imagery: preliminary results.

    PubMed

    Pu, Ruiliang

    2011-01-01

    A stepwise masking system with high-resolution IKONOS imagery was developed to identify and map urban forest tree species/groups in the City of Tampa, Florida, USA. The eight species/groups consist of sand live oak (Quercus geminata), laurel oak (Quercus laurifolia), live oak (Quercus virginiana), magnolia (Magnolia grandiflora), pine (species group), palm (species group), camphor (Cinnamomum camphora), and red maple (Acer rubrum). The system was implemented with soil-adjusted vegetation index (SAVI) threshold, textural information after running a low-pass filter, and brightness threshold of NIR band to separate tree canopies from non-vegetated areas from other vegetation types (e.g., grass/lawn) and to separate the tree canopies into sunlit and shadow areas. A maximum likelihood classifier was used to identify and map forest type and species. After IKONOS imagery was preprocessed, a total of nine spectral features were generated, including four spectral bands, three hue-intensity-saturation indices, one SAVI, and one texture image. The identified and mapped results were examined with independent ground survey data. The experimental results indicate that when classifying all the eight tree species/ groups with the high-resolution IKONOS image data, the identifying accuracy was very low and could not satisfy a practical application level, and when merging the eight species/groups into four major species/groups, the average accuracy is still low (average accuracy = 73%, overall accuracy = 86%, and κ = 0.76 with sunlit test samples). Such a low accuracy of identifying and mapping the urban tree species/groups is attributable to low spatial resolution IKONOS image data relative to tree crown size, to complex and variable background spectrum impact on crown spectra, and to shadow/shaded impact. The preliminary results imply that to improve the tree species identification accuracy and achieve a practical application level in urban area, multi-temporal (multi

  2. Preliminary results of the XR2-1 experiment

    SciTech Connect

    Gauntt, R.O.; Helmick, P.H.; Humphries, L.

    1996-03-01

    The XR2-1 (Ex-Reactor) experiment, investigating metallic core-melt relocation in boiling water reactor geometry, was performed on October 12, 1995, following two previous simpler XR1-series tests in August and November of 1993. The XR2-1 test made use of a highly detailed replication of the lower region of the BWR core, including the control blade and channel box structures, fuel rods, fuel canister nosepieces, control blade velocity limiter, and fuel support pieces, in order to investigate a key core melt progression uncertainty for BWR Station Blackout type accidents. The purpose of this experiment program is to examine the behavior of downward-draining molten metallic core materials in a severe reactor accident in a dry BWR core, and to determine conditions under which the molten materials drain out of the core region, or freeze to form blockages in the lower portion of the core. In the event that the draining metallic materials do not form stable blockages in the lower core region, and instead erode the lower core structures such as the lower core plate, then the subsequent core melt progression processes may proceed quite differently than was observed in the TMI-2 accident, with correspondingly different impact on vessel loading and vessel release behavior. The results of the Ex-Reactor tests are preliminary. All of the tests conducted have shown a significant degree of channel box destruction induced by the draining control blade materials. The XR2-1 test further showed that the draining zircaloy melt causes significant disruption of the fuel rod geometry. All of the tests have shown tendencies to form interim blockages as the melts temporarily freeze, but that these blockages re-melt, assisted by eutectic interactions, resulting in the sudden draining of accumulated metallic melt pools.

  3. Preliminary Results of the Effect of Microgravity on Seated Height

    NASA Technical Reports Server (NTRS)

    Rajulu, Sudhakar; Young, Karen; Mesloh, Miranda

    2011-01-01

    The new vehicle for future space travel to the International Space Station (ISS) and beyond will be highly dependent on the seat layout. A primary concern with the seat layout design of the new vehicle is the amount of seated height growth that occurs in space; this could cause a major accommodation issue. The design of the seats, seat layout, suit fit, and crew accommodation are all critically affected due to the increase in height that occurs in microgravity. The increase in height due to spinal elongation caused by the absence of gravity could lead to inadequate clearances that would have implications for the ability of crewmembers to return safely or to conduct nominal operations during the mission. This study was designed to reduce the risk of inadequate design of the vehicle, environment, tools, equipment, etc. (SHFE risk 2.3.1.1) and safely return crewmembers to earth from low-earth orbit travel, ISS, and beyond. In order to safely return the crewmembers, the design requirements must anticipate microgravity growth, elongation of the spine, bone and muscle loss, fluid shifts, etc. Thus, this study is to determine the amount of torso growth (spinal elongation) for a seated posture during Shuttle and ISS missions. Crewmembers seated heights were collected before, during, and after spaceflight to quantify the amount of growth that occurred as a result of microgravity. The changes in seated height will provide the designers with a design requirement which allows for change in spinal growth for a seated posture. Preliminary results have shown that , during flight, seated height increases by a range of approximately 2-6 percent compared to pre-launch seated height.

  4. Kepler K2 Precision Lightcurve Observations of Pluto: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Lisse, Casey M.; Benecchi, Susan D.; Binzel, Richard; Schwamb, Megan Elizabeth; New Horizons Science Team

    2016-10-01

    Pluto is a key object in the third zone of our Solar System and provides important insight into formation and collisional processes that were at work in the early solar system. In July 2015 the New Horizons spacecraft successfully obtained high resolution fly-by clear filter imaging observations of the Pluto system. We report on our continued monitoring of the Pluto system from October-December 2015 using the Kepler spacecraft's imaging photometer during Campaign 7 of the K2 extended mission (Howell et al. 2014). We obtained an unprecedented 83-day nearly continuous lightcurve with measurements every 30 minutes using Kepler's long cadence sampling. The result was 3,980 discrete, unresolved measurements of the combined Pluto system. The 3-month baseline allowed us to sample rotational variations and solar phase angles ranging from 1.1°-1.7° during the period of observation. This dataset is a key baseline for advancing the study of Pluto's actively evolving surface-atmosphere interaction as revealed by the surface geomorphology discovered by New Horizons. Our challenge is to gain an understanding of the ways in which Pluto's surface can be evolving as it recedes from the Sun, and of the influence of Pluto and Charon on each other. In this paper, we present our preliminary results from our K2 dataset. We describe the challenges in reducing the K2 lightcurve data for a target moving across the K2 FOV, and our progress in understanding the lightcurve's variability, which in our current reduction is due to a combination of systematics in the K2 dataset and inherent characteristics of the Pluto system's rotation and changing orbital geometry wrt the Sun and the Earth.This work was supported by NASA's K2 and New Horizons missions.

  5. [Hungarian Heart Failure Registry 2015-2016. Preliminary results].

    PubMed

    Nyolczas, Noémi; Heltai, Krisztina; Borbély, Attila; Habon, Tamás; Járai, Zoltán; Sziliczei, Erzsébet; Stadler, Péter; Faludi, Réka; Herczeg, Béla; Papp, Előd; Lakatos, Ferenc; Nagy, Katalin; Katona, András; Kovács, Imre; Tomcsányi, János; Nagy, András; Sepp, Róbert

    2017-01-01

    Heart failure is associated with a poor prognosis despite significant advances in the pharmacological and device therapy and incurs very high cost because of frequent hospitalizations. Therefore, professional high-quality care is essential for both patients and the healthcare system. The best way to evaluate the quality of care for a particular disease is the use of disease-specific registries. Until now, there has not been a registry evaluating characteristics and management of heart failure patients in Hungary. For that reason, the Hungarian Society of Cardiology initiated the set-up of the Hungarian Heart Failure Registry. The Aim of this paper is to present the goals, methods and first year results of the Hungarian Heart Failure Registry. The goal of the Registry is to create a modern, web-based database that summarizes the data of large number of patients who are currently or were previously admitted to hospital or who are currently or were previously patients in an outpatient department due to severe heart failure (NYHA III-IV). Currently 17 cardiology departments participate in the development of the Registry. The planned number of patients is 2000. Initially follow-up was planned for one year (pilot study). After the evaluation of the relevant experiences of the pilot study, long-term follow-up is planned. The Registry collects information about the type of heart failure (heart failure with reduced - LVEF≤45% - vs. preserved - LVEF>45% - ejection fraction), etiology, co-morbidities, diagnostic methods, treatment as well as morbidity and mortality. After the first year, assessing the baseline parameters of 698 patients enrolled in the Registry we found that the majority of patients (87.8%) has heart failure with reduced ejection fraction and in 39.8% of the patients heart failure has an ischaemic origin. The most frequent co-morbidity was hypertension followed by diabetes, renal insufficiency and COPD. The patients were treated with ACE inhibitors or ARBs

  6. Preliminary Characterization Results from the DebriSat Project

    NASA Technical Reports Server (NTRS)

    Rivero, M.; Shiotani, B.; Kleespies, J.; Toledo-Burdett, R.; Moraguez, M.; Carrasquila, M.; Fitz-Coy, N.; Liou, J.-C.; Sorge, M.; Huynh, T.

    2016-01-01

    preliminary results presented. Additionally, lessons learned from the implemented automations and their impacts on the integrity of the results are discussed.

  7. Autonomous Ozone and Aerosol Lidar Platform: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Strawbridge, K. B.

    2014-12-01

    Environment Canada is developing an autonomous tropospheric ozone and aerosol lidar system for deployment in support of short-term field studies. Tropospheric ozone and aerosols (PM10 and PM2.5) are important atmospheric constituents in low altitude pollution affecting human health and vegetation. Ozone is photo-chemically active with nitrogen oxides and can have a distinct diurnal variability. Aerosols contribute to the radiative budget, are a tracer for pollution transport, undergo complex mixing, and contribute to visibility and cloud formation. This particular instrument will employ two separate lidar transmitter and receiver assemblies. The tropospheric ozone lidar, based on the differential absorption lidar (DIAL) technique, uses the fourth harmonics of a Nd:YAG laser directed into a CO2 Raman cell to produce 276 nm, 287nm and 299 nm (first to third Stokes lines) output wavelengths. The aerosol lidar is based on the 3+2 design using a tripled Nd:YAG to output 355 nm, 532 nm and 1064nm wavelengths. Both lidars will be housed in a modified cargo trailer allowing for easy deployment to remote areas. The unit can be operated and monitored 24 hours a day via an internet link and requires an external power source. Simultaneous ozone and aerosol lidar measurements will provide the vertical context necessary to understand the complex mixing and transformation of pollutants - particularly when deployed near other ground-based in-situ sensors. Preliminary results will be shown from a summer field study at the Centre For Atmospheric Research Experiments (CARE).

  8. COSMIC EVOLUTION OF DUST IN GALAXIES: METHODS AND PRELIMINARY RESULTS

    SciTech Connect

    Bekki, Kenji

    2015-02-01

    We investigate the redshift (z) evolution of dust mass and abundance, their dependences on initial conditions of galaxy formation, and physical correlations between dust, gas, and stellar contents at different z based on our original chemodynamical simulations of galaxy formation with dust growth and destruction. In this preliminary investigation, we first determine the reasonable ranges of the most important two parameters for dust evolution, i.e., the timescales of dust growth and destruction, by comparing the observed and simulated dust mass and abundances and molecular hydrogen (H{sub 2}) content of the Galaxy. We then investigate the z-evolution of dust-to-gas ratios (D), H{sub 2} gas fraction (f{sub H{sub 2}}), and gas-phase chemical abundances (e.g., A {sub O} = 12 + log (O/H)) in the simulated disk and dwarf galaxies. The principal results are as follows. Both D and f{sub H{sub 2}} can rapidly increase during the early dissipative formation of galactic disks (z ∼ 2-3), and the z-evolution of these depends on initial mass densities, spin parameters, and masses of galaxies. The observed A {sub O}-D relation can be qualitatively reproduced, but the simulated dispersion of D at a given A {sub O} is smaller. The simulated galaxies with larger total dust masses show larger H{sub 2} and stellar masses and higher f{sub H{sub 2}}. Disk galaxies show negative radial gradients of D and the gradients are steeper for more massive galaxies. The observed evolution of dust masses and dust-to-stellar-mass ratios between z = 0 and 0.4 cannot be reproduced so well by the simulated disks. Very extended dusty gaseous halos can be formed during hierarchical buildup of disk galaxies. Dust-to-metal ratios (i.e., dust-depletion levels) are different within a single galaxy and between different galaxies at different z.

  9. Environment modelling in near Earth space: Preliminary LDEF results

    NASA Technical Reports Server (NTRS)

    Coombs, C. R.; Atkinson, D. R.; Wagner, J. D.; Crowell, L. B.; Allbrooks, M.; Watts, A. J.

    1992-01-01

    Hypervelocity impacts by space debris cause not only local cratering or penetrations, but also cause large areas of damage in coated, painted or laminated surfaces. Features examined in these analyses display interesting morphological characteristics, commonly exhibiting a concentric ringed appearance. Virtually all features greater than 0.2 mm in diameter possess a spall zone in which all of the paint was removed from the aluminum surface. These spall zones vary in size from approximately 2 - 5 crater diameters. The actual craters in the aluminum substrate vary from central pits without raised rims, to morphologies more typical of craters formed in aluminum under hypervelocity laboratory conditions for the larger features. Most features also possess what is referred to as a 'shock zone' as well. These zones vary in size from approximately 1 - 20 crater diameters. In most cases, only the outer-most layer of paint was affected by this impact related phenomenon. Several impacts possess ridge-like structures encircling the area in which this outer-most paint layer was removed. In many ways, such features resemble the lunar impact basins, but on an extremely reduced scale. Overall, there were no noticeable penetrations, bulges or spallation features on the backside of the tray. On Row 12, approximately 85 degrees from the leading edge (RAM direction), there was approximately one impact per 15 cm(exp 2). On the trailing edge, there was approximately one impact per 72 cm(exp 2). Currently, craters on four aluminum experiment trays from Bay E09, directly on the leading edge are being measured and analyzed. Preliminary results have produced more than 2200 craters on approximately 1500 cm(exp 2) - or approximately 1 impact per 0.7 cm(exp 2).

  10. Polyurethane-Covered Self-expandable Nitinol Stent for Malignant Biliary Obstruction: Preliminary Results

    SciTech Connect

    Han, Young-Min; Hwang, Seung-Bae; Lee, Soo-Teik; Lee, Jeong-Min; Chung, Gyung-Ho

    2002-10-15

    Purpose: To evaluate the immediate and long-term results in ten patients with malignant biliary obstruction using a polyurethane-covered, self-expandable nitinol stent.Methods: A nitinol stent, fully covered with high-elasticity polyurethane, with an unconstrained diameter of 10 mm and a total length of 60-80 mm, was placed transhepatically under fluoroscopic guidance in ten patients. The length of the biliary obstruction varied between 30-50 mm. The follow-up examination included a clinical assessment, serum bilirubin measurement, and ultrasound examinations at one-month intervals in all patients. Results: Initial stent deployment was successful in eight patients. Two patients experienced proximal migration,which was solved by insertion of two, uncovered Wallstents. One patient had the stent removed after two weeks because of severe nausea and vomiting. One patient had delayed migration of the covered stent after 40 weeks. The follow-up duration was 3-40 weeks (Mean: 16.9 weeks). Seven patients died(3-26 weeks) and three patients survived (24-40 weeks). The bilirubin measurements in all patients had significantly decreased one week after stent insertion. The levels of amylase and lipase had did not increase after stent insertion. Conclusions: Apolyurethane-covered, self-expandable nitinol stent can be used effectively and safely in the treatment of malignant biliary obstruction. The preliminary results are favorable, but there is a need for further large studies to determine both long-term survival and patency.

  11. Fireball of 30 May 2017 over NE Italy: Preliminary results

    NASA Astrophysics Data System (ADS)

    Stomeo, Enrico; Eltri, Maurizio

    2017-03-01

    A big fireball has been observed in Northern Italy at 21h09m22s UT on 30 May 2017. The fireball was registered by 3 video cameras of the Italian Meteor Group and observed by many visual people. The preliminary trajectory above the area between Romagna and Veneto regions was calculated.

  12. Preliminary Results from a Mercury Dry Deposition Measurement Methods Intercomparison

    NASA Astrophysics Data System (ADS)

    Marsik, F. J.; Brooks, S.; Gustin, M. S.; Holsen, T.; Landis, M.; Prestbo, E. M.; Poissant, L.

    2009-12-01

    Over the past fifteen years, a number of intensive field campaigns and measurement networks have provided valuable information on the estimated rates of mercury wet deposition to sensitive ecosystems throughout the world. In contrast, the ability to place bounds on the rates of mercury dry deposition has been hampered by the relative lack of direct measurements of this process. Recently, a number of researchers have performed measurements of mercury dry deposition using a variety of direct and indirect measurement techniques. While these studies have provided important information regarding the potential rates of mercury dry deposition to natural surfaces, little is known about the comparability of the results utilizing these different measurement approaches. During the month of August 2008, a mercury dry deposition measurement methods comparison was conducted in Ann Arbor, Michigan over a nine-day period. Seven research groups participated in the study, with the following measurement approaches: water, cation exchange membrane, chemically treated filter and turf surrogate surfaces; and several micrometeorological modeling methods. Continuous monitoring was conducted for ambient meteorological conditions and elemental, oxidized and particulate mercury concentrations. Preliminary results suggest that study-average mercury dry deposition estimates ranged from 0.17 to 0.59 ng/m2/hour for the group of pure-water surrogate surfaces, the cation exchange membrane and a micrometeorological flux gradient approach. The turf surrogate surface, BrCl spiked-water surface and a gold-coated quartz fiber filter surface resulted in significantly higher mercury dry deposition estimates, with the latter two approaches having been designed to measure total mercury dry deposition. Given that the turf surrogate surface and the cation exchange membrane samplers were designed for long-term deployment (up to one week), these methods were deployed for an additional series of four one

  13. Auditory discrimination therapy (ADT) for tinnitus managment: preliminary results.

    PubMed

    Herraiz, C; Diges, I; Cobo, P; Plaza, G; Aparicio, J M

    2006-12-01

    This clinical assay has demonstrated the efficacy of auditory discrimination therapy (ADT) in tinnitus management compared with a waiting-list group. In all, 43% of the ADT patients improved their tinnitus, and its intensity together with its handicap were statistically decreased (EMB rating: B-2). To describe the effect of sound discrimination training on tinnitus. ADT designs a procedure to increase the cortical representation of trained frequencies (damaged cochlear areas with a secondary reduction of cortical stimulation) and to shrink the neighbouring over-represented ones (corresponding to tinnitus pitch). This prospective descriptive study included 14 patients with high frequency matched tinnitus. Tinnitus severity was measured according to a visual analogue scale (VAS) and the Tinnitus Handicap Inventory (THI). Patients performed a 10-min auditory discrimination task twice a day for 1 month. Discontinuous 8 kHz pure tones were randomly mixed with 500 ms 'white noise' sounds through a MP3 system. ADT group results were compared with a waiting-list group (n=21). In all, 43% of our patients had improvement in their tinnitus. A significant improvement in VAS (p=0.004) and THI mean scores was achieved (p=0.038). Statistical differences between ADT and the waiting-list group have been proved, considering patients' self-evaluations (p=0.043) and VAS scores (p=0.004). A non-significant reduction of THI was achieved (p=0.113).

  14. Boreal Summer ISO hindcast experiment: preliminary results from SNU

    NASA Astrophysics Data System (ADS)

    Heo, S.; Kang, I.; Kim, D.; Ham, Y.

    2010-12-01

    As a part of internationally coordinated research program, hindcast experiments with focus on boreal summer intraseasonal oscillation (ISO) have been done in Seoul National University (SNU). This study aims to show preliminary results from SNU’s efforts. The ISO prediction system used in the hindcast experiment consists of SNU coupled model and SNU initialization method. The SNU coupled model is an ocean-atmosphere coupled model which couples the SNU Atmospheric GCM (SNU AGCM) to the Modular Ocean Model ver.2.2 (MOM2.2) Ocean GCM developed at Geophysical Fluid Dynamics Laboratory (GFDL). In the SNU initialization method, both atmospheric and oceanic states are nudged toward reanalysis data (ERAinterim and GODAS) before prediction starting date. For the results here, 2 ensemble members are generated by using different nudging period, 8 and 9 days, respectively. The initial dates of 45-day predictions are the 1st, 11th, 21st of months during boreal summer season (May to October). Prediction skills and its dependency on the initial amplitude, the initial phase, and the number of ensemble members are investigated using the Real-time Multivariate MJO (RMM) index suggested by Wheeler and Hendon (2004). It is shown in our hindcast experiment that, after 13 forecast lead days (the forecast skill is about 0.7), the prediction skill does not depend on the strength of the initial state. Also, we found that the prediction skill has a phase dependency. The prediction skill is particularly low when the convective center related to the MJO is over the Indian Ocean (phase 2). The ensemble prediction has more improved correlation skill than each member. To better understand the phase dependency, we compared the observed and predicted behavior of the MJO that propagates from different starting phases. The phase speed of the prediction is slower than the observation. The MJO in the hindcast experiment propagates with weaker amplitudes than observed except for initial phase 3. Also

  15. Mycodiversity in marine sediments contaminated by heavy metals: preliminary results

    NASA Astrophysics Data System (ADS)

    Zotti, Mirca; Carbone, Cristina; Cecchi, Grazia; Consani, Sirio; Cutroneo, Laura; Di Piazza, Simone; Gabutto, Giacomo; Greco, Giuseppe; Vagge, Greta; Capello, Marco

    2016-04-01

    .6 CFU per gram of sediments. The maximum value of 11 CFU g-1 has been recorded in two stations (off the Sestri Levante Tombolo), while the minimum value has been recorded closer to the coast. As concern qualitative results, the most recurrent genera are Aspergillus and Penicillium. These data confirm the occurrence of a mycobiota in these heavy metal contaminated sediments. Our preliminary results are a first contribution to the knowledge of presence of microfungi in marine sediments, and propel us to increase our research in order to find out new organisms for bioremediation purpose.

  16. Equation of state and compressional behaviour of edingtonite: preliminary results.

    NASA Astrophysics Data System (ADS)

    Gatta, G. D.; Boffa Ballaran, T.; Comodi, P.; Zanazzi, P. F.

    2003-04-01

    Edingtonite is Ba-zeolite, belonging to the fibrous zeolites group. Its chemical composition is approximately BaAl_2Si_3O10\\cdot4H_2O. The crystal framework is based on Secondary Building Unit (SBU), constituted by four-member tetrahedral rings joined by a fifth tetrahedron to form [100]-chains (topological symmetry Ioverline{4} 2_1m). The framework is characterized by two systems of channels: 8-ring channels along [110] and 8-ring channels along [001]. Orthorhombic edingtonites arise due to Si/Al-ordering, whereas Si/Al-disorder increases the symmetry to tetragonal. The extraframework cations and water molecules lay in the [001]-channels: the Ba atoms are located in the center of the channels and are coordinated to six framework oxygens and four water molecules. The baric behaviour of tetragonal edingtonite from Ice River (Canada) was investigated by X-ray single-crystal diffraction with a BGI diamond anvil cell using glycerol as a non-penetrating pressure medium and quartz as pressure calibrant. Cell volume data were fitted using a second order Birch-Murnaghan Equation of State, as suggested by finite strain - stress plot (f-F_e plot). The preliminary results are: V_0= 601.5(3) Å^3 and K_0= 61(2) GPa, with K'=4 . The axial compressibility values, obtained fitting the lattice data with a second order "linearized" Murnaghan Equation of State, are: β_a = β_b=1.86(7)\\cdot10-2 GPa-1, β_c = 1.27(5)\\cdot 10-2 GPa-1 (β_a : β_b: β_c =1.46 : 1.46 :1). No phase transition has been observed up to 2.2 GPa. The evolution of the crystal structure with P was studied by comparing the results of refinements done with data collected at different pressures. The main deformation mechanism is the polyhedral tilting that produced inter-tetrahedral angle variations. In particular, the relevant structural variations are produced by cooperative rotation of the SBUs along [100]. This mechanism produces an increase in the ellipticity of the [100]-channel. Similar behaviour has

  17. Toward DNA-based facial composites: preliminary results and validation.

    PubMed

    Claes, Peter; Hill, Harold; Shriver, Mark D

    2014-11-01

    The potential of constructing useful DNA-based facial composites is forensically of great interest. Given the significant identity information coded in the human face these predictions could help investigations out of an impasse. Although, there is substantial evidence that much of the total variation in facial features is genetically mediated, the discovery of which genes and gene variants underlie normal facial variation has been hampered primarily by the multipartite nature of facial variation. Traditionally, such physical complexity is simplified by simple scalar measurements defined a priori, such as nose or mouth width or alternatively using dimensionality reduction techniques such as principal component analysis where each principal coordinate is then treated as a scalar trait. However, as shown in previous and related work, a more impartial and systematic approach to modeling facial morphology is available and can facilitate both the gene discovery steps, as we recently showed, and DNA-based facial composite construction, as we show here. We first use genomic ancestry and sex to create a base-face, which is simply an average sex and ancestry matched face. Subsequently, the effects of 24 individual SNPs that have been shown to have significant effects on facial variation are overlaid on the base-face forming the predicted-face in a process akin to a photomontage or image blending. We next evaluate the accuracy of predicted faces using cross-validation. Physical accuracy of the facial predictions either locally in particular parts of the face or in terms of overall similarity is mainly determined by sex and genomic ancestry. The SNP-effects maintain the physical accuracy while significantly increasing the distinctiveness of the facial predictions, which would be expected to reduce false positives in perceptual identification tasks. To the best of our knowledge this is the first effort at generating facial composites from DNA and the results are preliminary

  18. Preliminary Results from an Hydroacoustic Experiment in the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Royer, J.; Dziak, R. P.; Delatre, M.; Brachet, C.; Haxel, J. H.; Matsumoto, H.; Goslin, J.; Brandon, V.; Bohnenstiehl, D. R.; Guinet, C.; Samaran, F.

    2008-12-01

    We report initial results from a 14-month hydroacoustic experiment in the Indian Ocean conducted by CNRS/University of Brest and NOAA/Oregon State University. The objective was to monitor the low-level seismic activity associated with the three contrasting spreading ridges and deforming zones in the Indian Ocean. Three autonomous hydrophones, moored in the SOFAR channel, were deployed in October 2006 and recovered early 2008 by R/V Marion Dufresne, in the Madagascar Basin, and northeast and southwest of Amsterdam Island, complementing the two permanent hydroacoustic stations of the Comprehensive nuclear-Test-Ban Treaty Organization (CTBTO) located near Diego Garcia Island and off Cape Leeuwin. Our temporary network detected more than 2000 events. Inside the array, we located 592 events (compared to 49 in the NEIC earthquake catalog) with location errors less than 5 km and time error less than 2s. The hydrophone array detected on average 5 to 40 times more events per month than land-based networks. First-order observations indicate that hydroacoustic seismicity along the Southeast Indian ridge (SEIR) occurs predominantly along the transform faults. The Southwest Indian Ridge exhibits some periodicity in earthquake activity between adjacent ridge segments. Two large tectonic/volcanic earthquake swarms are observed along the Central Indian Ridge (near the triple junction) in September and December 2007. Moreover, many off ridge-axis events are also observed both south and north of the SEIR axis. Improved localization using the CTBTO records will help refine these preliminary results and further investigate extended volcanic sequences along the SEIR east of 80°E and other events outside of the temporary array. The records also display numerous vocalizations of baleen whales in the 20-40Hz bandwidth. The calls are attributed to fin whales, Antarctic blue whales and pygmy blue whales of Madagascar and Australian type. Their vocal activity is found to be highly seasonal

  19. [Sarcoma developed in irradiated area: Preliminary results of the SARI trial].

    PubMed

    Maingon, P; Mirjolet, C; Diallo, I; Veres, C; Collin, F; Italiano, A; Chibon, F; Merlin, J L; Coindre, J M

    2016-10-01

    Radiotherapy and surgery are the two main pillars of the locoregional treatment of cancer. The risk of second malignancy is better evaluated and constitutes a major issue regarding radioprotection of the patients. Among malignant disease observed in the surviving irradiated patients, the occurrence of sarcoma is a rare event but associated with a poor outcome since the 5 year overall survival is estimated at 10 to 35 %. The SARI protocol, written in 2011, included 120 patients and 240 controlled patients, irradiated in the same conditions but without sarcoma observed during the follow up. The main objective was to identify the clinical and biological factors associated with the occurrence of such a complication. The secondary objective was to identify the dosimetric characteristics of the treatment of the primary. Preliminary results will be presented during the 2016 meeting of the French radiation oncology society.

  20. Pharyngeal Airway Changes after Bimaxillary Orthognathic Surgery--Preliminary Results.

    PubMed

    Stefanović, Neda Lj; Glišić, Branislav; Nikolić, Predrag V; Juloski, Jovana; Palomo, Juan Martin

    2015-01-01

    Dentofacial deformity, a deviation from normal facial proportions and dental relationships, is corrected by jaw repositioning in all three spatial planes, which changes the position and tension of the surrounding tissues, bones and muscles. These changes may also affect the dimensions of the pharyngeal airways (PA). The aim of this study was to evaluate and compare three-dimensional PA changes in patients treated by a combination mandibular set-back/maxillary advancement versus patients that had bimaxillary advancement with genioplasty. The sample consisted of 7 patients treated by combined mandibular set-back/maxillary advancement and 7 patients treated with bimaxillary advancement surgery. Nasopharyngeal (NP) volume, oropharyngeal (OP) volume and the area of maximum constriction (AMC) in the OP were measured on CBCT scans (2 mA/120 kV/12" FOV) taken before (T1) and 3 months after surgery (T2). Paired samples t-test was used for analyzing statistical significance of changes (p ≤ 0.05). OP volume and AMC increase after bimaxillary advancement was statistically significant, while for the mandibular set-back group the increase was non-significant. NP volume was not reduced in any of the two groups. No significant differences in PA dimensions were found between groups at neither T1 nor T2 time points. Results suggest that the combination of mandibular set-back/maxillary advancement did not reduce airway dimensions, while bimaxillary advancement surgery led to a statistically significant increase in the OP dimensions.

  1. The ototronix MAXUM middle ear implant for severe high-frequency sensorineural hearing loss: Preliminary results.

    PubMed

    Hunter, Jacob B; Carlson, Matthew L; Glasscock, Michael E

    2016-09-01

    To report the preliminary results of the Ototronix MAXUM middle ear implant for treatment of severe high-frequency sensorineural hearing loss. Case series with chart review. Six consecutive ears with severe high-frequency sensorineural hearing loss (≥75 dB HL at 2, 3, and 4 kHz) and poor aided word recognition performance (≤60% single words) underwent implantation of the MAXUM system at a single, private otologic referral center. Primary outcome measures included frequency-specific functional gain and word recognition score improvement compared to optimally fitted hearing aids. Six ears, in four adult patients (two female; median age 67.5 years) were included. The median unaided preoperative high-frequency pure-tone average (HFPTA) (2, 3, and 4 kHz) was 80.0 dB (range, 75.0-85.0 dB), and the median best-aided word recognition score was 48.0% (range, 24%-60%). The median HFPTA functional gain with the MAXUM system was 47.2 dB, a 25.0 dB improvement (range, 16.7-33.3 dB) (P = .03) over optimally fit hearing aids, and the median word recognition score with MAXUM was 81.5%, a 42.0% improvement (range, 20%-48%) (P = .03) with the MAXUM middle ear implant over optimally fitted hearing aids. These preliminary data demonstrate that the MAXUM middle ear implant provides superior functional gain and word recognition scores in quiet for patients with severe high-frequency sensorineural hearing loss compared to optimally fitted hearing aids. Future studies with greater patient numbers and patient reported outcome measures are needed to confirm these promising but preliminary results. 4 Laryngoscope, 126:2124-2127, 2016. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  2. Fluorine Diffusion in Titanite: Preliminary Results from Experiments

    NASA Astrophysics Data System (ADS)

    Berds, M. L.; Price, J. D.; Cherniak, D. J.

    2008-12-01

    Recent experiments have yielded new data on fluorine-hydroxyl diffusion in titanite. Experiments utilized natural low-F titanite crystals, sectioned into wafers, polished to 1 μm alpha alumina and finished with colloidal silica. Prepared crystals were placed with polished faces in contact with a F-rich diffusion source. Each titanite-source assembly was then sealed in an evacuated Si glass ampoule and heated to temperatures between 600 and 900 °C, or sealed in an Ag envelope and heated in a cold-seal pressure vessel to temperatures between 600 and 906 °C at 50 to 100 kPa. Several F sources were employed: PbF, NaF, CaF2, LiF, and fluoroapatite. PbF and NaF strongly reacted with the titanite crystals and their capsules, particularly at higher temperatures. CaF2 and LiF were less destructive, but reacted with and etched the titanite faces, precluding analysis. Titanite retained a polished and largely unaltered surface only in those runs with an apatite source. We noted only a slight change in color (green to brown, likely due to oxidation of minor amounts of Fe present in the titanite) in these runs. We analyzed the polished faces of crystals from successful experiments using nuclear reaction analysis (NRA), employing the 340 keV resonance for the nuclear reaction 19F(p,αγ) 16O to measure fluorine. The results show elevated fluorine at the surface and diminishing concentrations with depth. Fitting a simple complementary error function to each concentration profile yields a diffusivity, assuming a model of a semi-infinite material with a surface maintained at constant concentration. For the runs at near atmospheric pressure, diffusion coefficients of 2×10-21m2/s and 6×10-21m2/s are obtained at temperatures of 850°C and 889°C, respectively. A single cold seal experiment at 906°C suggests a diffusivity of 3×10-21 m2/s. While preliminary, these data suggest that fluorine-hydroxyl exchange in titanite is more sluggish than in apatite, biotite, and tremolite.

  3. Preliminary Results from the PYTHON Microwave Background Anisotropy Experiment

    NASA Astrophysics Data System (ADS)

    Dragovan, M.; Ruhl, J.; Novak, G.; Platt, S. R.; Crone, B.; Pernic, R.

    1993-05-01

    We will present preliminary results of our experiment to measure the anisotropy of the microwave background on medium (2.75 degree) angular scales. Observations of 14 separate regions (two rows of seven regions) on the sky were made during the 15 day period of 1 Jan to 15 Jan 1993. The observing site, the geographic South Pole, is an ideal location for microwave background anisotropy studies where long integration times, low sky background (10K at 90GHz), and stable atmospheric conditions are required. The geometric advantage of the Pole is that a patch of sky never rises or sets, allowing 24 hour observations of the patch with no corrections required for changes in elevation. Approximately 100 hours of usable data were obtained during this time. The instrument is a five channel bolometer array, with the detectors operating at 50 mK, cooled by a hybrid (3) He-Adiabatic demagnetization refrigerator. There are four pixels in the focal plane arranged in a square grid so that the angular separation between pixels on the sky is 2.75 degrees. The fifth channel is a dark channel acting as a monitor for extraneous noise or pickup. Individual pixels consist of corrugated feedhorns coupled to waveguide waffle filters combined with glass and plastics to define the high frequency cutoff (110 GHz); the low frequency cutoff is determined by the cutoff of the waveguide (75 GHz). The band was selected for minimal expected contributions from foreground sources such as free-free, synchrotron and cool dust. This detector system is coupled to the sky via a 0.75m off axis parabolic primary. A gradient free 3-beam switching pattern on the sky is obtained by moving a low moment of inertia flat plate quickly (15 msec transition time, with 85 msec spent integrating on the point) between 3 points on the sky. The plate is oriented vertically so the switching is at constant elevation. This work was supported by The Center for Astrophysics in Antarctica, PYI grant NSF AST-9057089 and the James

  4. Mapping the contours of the Local bubble: preliminary results

    NASA Astrophysics Data System (ADS)

    Sfeir, D. M.; Lallement, R.; Crifo, F.; Welsh, B. Y.

    1999-06-01

    We present preliminary results from a long-term program of mapping the neutral absorption characteristics of the local interstellar medium, taking advantage of Hipparcos stellar distances. Equivalent widths of the NaI D-line doublet at 5890 Å are presented for the lines-of-sight towards some 143 new target stars lying within 300 pc of the Sun. Using these data which were obtained at the Observatoire de Haute Provence, together with previously published NaI absorption measurements towards a further 313 nearby targets, we present absorption maps of the distribution of neutral gas in the local interstellar medium as viewed from 3 different galactic projections. In particular, these maps reveal the Local Bubble region as a low neutral density interstellar cavity in the galactic plane with radii between 65-250 pc that is surrounded by a (dense) neutral gas boundary (or ``wall''). We have compared our iso-column contours with the contours derived by Snowden et al. (\\cite{snowden98}) using ROSAT soft X-ray emission data. Consistency in the global dimensions derived for both sets of contours is found for the case of a million degree hot LB plasma of emissivity 0.0023 cm(-6) pc with an electron density of 0.005 cm(-2) . We have detected only one relatively dense accumulation of cold, neutral gas within 60 pc of the Sun that surrounds the star delta Cyg, and note that the nearest molecular cloud complex of MBM 12 probably resides at the very edge of the Local Bubble at a distance of ~ 90 pc. Our observations may also explain the very different physical properties of the columns of interstellar gas in the line-of-sight to the two hot stars epsilon CMa and beta CMa as being due to their locations with respect to the Bubble contours. Finally, in the meridian plane the LB cavity is found to be elongated perpendicularly to the Gould's Belt plane, possibly being ``squeezed'' by the expanding shells of the Sco-Cen and Perseus-Taurus OB associations. Tables 1 and 2 are also

  5. Some Preliminary Scientific Results of Chang'E-3 Mission

    NASA Astrophysics Data System (ADS)

    Zou, Y.; Li, W.; Zheng, Y.; Li, H.

    2015-12-01

    Chang'E-3 mission is the main task of Phase two of China Lunar Exploration Program (CLEP), and also is Chinese first probe of landing, working and roving on the moon. Chang'E-3 craft composed of a lander and a rover, and each of them carry four scientific payloads respectively. The landing site of Chang'E-3 was located at 44.12 degrees north latitude and 19.51 degrees west longitude, where is in the northern part of Imbrium Which the distance in its west direction from the landing site of former Soviet probe Luna-17 is about 400 km, and about 780km far from the landing site of Appolo-17 in its southeast direction. Unfortunately, after a series of scientific tests and exploration on the surface of the moon, the motor controller communication of the rover emerged a breakdown on January 16, 2014, which leaded the four payloads onboard the rover can't obtain data anymore. However, we have received some interesting scientific data which have been studied by Chinese scientists. During the landing process of Chang'E-3, the Landing camera got total 4673 images with the Resolution in millimeters to meters, and the lander and rover took pictures for each other at different point with Topography camera and Panoramic camera. We can find characteristic changes in celestial brightness with time by analyzing image data from Lunar-based Ultraviolet Telescope (LUT) and an unprecedented constraint on water content in the sunlit lunar exosphere seen by LUT). The figure observed by EUV camera (EUVC) shows that there is a transient weak area of the Earth's plasma sphere; This event took place about three hours. The scientists think that it might be related to the change of the particle density of mid-latitude ionosphere. The preliminary spectral and mineralogical results from the landing site are derived according to the data of Visible and Near-infrared Imaging Spectrometer (VNIS). Seven major elements including Mg, Al, Si, K, Ca, Ti and Fe have been identified by the Active Particle

  6. Preliminary meteorological results for 1992 West Coast Scotland Experiment

    SciTech Connect

    Robey, H.F.

    1993-01-04

    This memo documents preliminary meteorological results from the 1992 West Coast Scotland Experiment, a joint US/UK radar ocean imaging experiment. Measurements of wind speed and direction are reported for both phases of the experiment covering the periods from June 7--13 and from June 19--25. The measurements were obtained using a Campbell Scientific CR10 Datalogger and R. M. Young model 03001-5 anemometer and wind wane. The anemometer has a resolution of 0.1 m/s and the wind vane 1[degrees], but motion of the ship platform reduces the precision of the direction measurements to [+-]10[degrees]. Data were downloaded to an IBM PC-AT for final storage and analysis. The anemometer was mounted at a height of 10 meters above the mean water surface on top of a mast located at the bow of the Royal Marine Auxiliary Service (R.M.A.S.) tug, [open quotes]Cairn[close quotes]. The Cairn was moored at the center of the experiment site at 57[degrees]7.13755[close quote] N, 5[degrees]44.88521[close quote] W in the Sound of Sleat. nominally 200 meters from the ship track. Wind velocity and direction were recorded at a sample rate of 0.2 Hz, and the averaged value was output every 10 minutes from approximately 2 hours before the start of the first run to 2 hours after the end of the last run. Data are plotted in the following pages in 2 formats for a quick visual summary of the daily wind conditions. The top plot gives wind velocity (m/s) and direction (degrees true) vs. time given in minutes relative to the start of the first run which is designated as [open quotes]T[close quotes]. The lower plot gives a polar plot of the same data with velocity on the radial axis and direction on the azimuthal axis. The final two plots give a summary of the wind speed vs. direction for phase 1 (June 7--13) and phase 2 (June 19--25).

  7. Real time evaluation of monolateral clubfoot with sonoelastography. Preliminary results

    PubMed Central

    Masala, Salvatore; Manenti, Guglielmo; Antonicoli, Marco; Morosetti, Daniele; Claroni, Giulia; Simonetti, Giovanni

    2012-01-01

    Summary Purpose: to assess the real time elastosonography (RTE) as a primary diagnostic tool for the evaluation of mechanical properties of Achilles tendons in patients affected by not surgically treated monolateral clubfoot. Materials and method: six patients were evaluated, four males and two females, mean age 1.2 ± 1.3 months, treated with Ponseti method, and afterward, they underwent RTE examination of the Achilles tendon in club-foot. A following ROI (region of interest) was positioned on the distal third of the tendon and the obtained data was examined retrospectively. Results: in the examined cohort of patients, the mean value ROI 1/mean value ROI 2 ratio was 2.0 ± 0.18, with an increased red area in the RTE evaluation of the affected tendon, while in the contralateral foot the mean observed value was 2.50 ± 2.1. Conclusion: RTE is a feasible and simple technique, which allows the study of the mechanical properties of Achilles tendons in children with clubfoot. PMID:23738274

  8. Intravesical Sodium Chondroitin Sulphate to Treat Overactive Bladder: Preliminary Result.

    PubMed

    Irkilata, Lokman; Aydin, Mustafa; Riza Aydin, Hasan; Cihan Demirel, Hüseyin; Kadihasanoglu, Mustafa; Kemal Atilla, Mustafa

    2015-06-01

    This study aimed to verify the efficacy and safety of intravesical treatment with sodium chondroitin sulfate (CS) in patients with overactive bladder (OAB) who are refractory to previous antimuscarinic treatment. This study was performed between June 2012 and January 2015 and included 31 consecutive women (mean age, 42.10±7.34 years) with OAB who had been previously treated with two types of antimuscarinic drugs. The results of gynecologic and cystoscopic examinations were normal, and OAB comorbidity was absent. Treatment with intravesical instillations containing 40 mL CS (0.2%; 2 mg/mL) was administered for 6 weeks; after weekly treatments, monthly treatments were administered. The OAB-validated 8 (OAB-V8) symptom scores, nocturia, frequency, urgency, urge incontinence, and urinary volumes measured by uroflowmetry were evaluated for all the patients. The values obtained before the treatment were statistically compared with those obtained six months after the treatment. The duration of the symptoms was 18.36±6.19 months. A statistically significant improvement of the patients' conditions was observed in terms of the OAB-V8 symptom scores, nocturia, frequency, urgency, urge incontinence, and urinary volumes measured by uroflowmetry after the treatment. Despite the limitations of this study, the outcomes confirmed that CS therapy is safe and effective for the treatment of OAB.

  9. [Discontinuous warm cardioplegia in pediatric cardiac surgery: preliminary results].

    PubMed

    Durandy, Y; Hulin, S

    2006-02-01

    This article describes the use of warm cardioplegia in paediatric surgery. Warm blood enriched with potassium was injected every 15 minutes during aortic clamping in 770 operations. The efficacy and quality of this technique were assessed by the return of cardiac electrical activity, troponin I levels 12 hours after aortic clamping and the duration of postoperative ventilation in 3 groups of patients: ventricular septal defect under 6 months (N = 82), tetralogy of Fallot under one year (N = 55), simple transposition of the great arteries (N = 42). These results were compared retrospectively with those obtained using cold cardioplegia. The return of sinus rhythm was spontaneous in 99% of cases versus 77% with cold cardioplegia; the troponin I levels were under 10 ng/ml in 46% of cases versus 37% (NS). Patients operated for ventricular septal defect were ventilated 10 +/- 8 hours versus 13 +/- 10 hours with cold cardioplegia (p = 0.02). The children operated for tetralogy of Fallot were ventilated 8 +/- 4 hours versus 14 +/- 7 hours (p = 0.01) and those with simple transposition 56 +/- 71 hours versus 83 +/- 105 hours (NS). Warm cardioplegia, in the authors' experience, was associated with an improved postoperative course. In this group of 770 operations, 646 operated patients had a stay of less than two days in the intensive care unit.

  10. Preliminary results of the PREFER FP7 Project

    NASA Astrophysics Data System (ADS)

    Fusilli, Lorenzo; Laneve, Giovanni; De Bonis, Roberto; Sebastian, Ana; Ferrucci, Fabrizio; Oliveira, Sandra

    2014-05-01

    The need to improve the information and intelligence support for forest fire prevention is widely recognized. Fire prevention is still the most cost-effective strategy when compared to firefighting and extinguishing that are costly, local, and triggered only in response to already ongoing crises. PREFER project, funded under the EU FP7 (G.A. 312931), intends to contribute at responding to such a pragmatic need of southern Europe's forests by: providing timely information products based on the exploitation of all available spacecraft sensors, offering a portfolio of products focused on pre- and post-crisis forest fire emergency, suitable for the users in the different countries of the European Mediterranean area. The PREFER Service portfolio consists of two main services: 1. Information Support to Fire Preparedness/Prevention Phase" (ISP) Service 2. Information Support to Fire Recovery/Reconstruction Phase" (ISR) Service This service is already at an advanced stage having completed the first year of activity. During this time several products have been consolidated: seasonal fuel maps; daily and seasonal fire hazard maps; seasonal risk maps; prescribed fire maps. This paper aims at presenting the preliminary results of the research activity carried out in the framework of the PREFER project, focusing, in particular, on these recalled above. As for Fire Risk and Hazard assessment, many indexes have been developed in the last years. Hardly any of them uses data derived from satellite images. The FPI index is an exception to this rule which, in addition, makes use of meteorological data. In spite of being a very complete index, the FPI still allows room for improvement which justify the interest of PREFER in it. PREFER's innovative approach to FPI will allow taking into account the effect of solar illumination conditions in determining the humidity present in the dead vegetation, and therefore its proneness to burn. PREFER innovation also focus in allowing the index to

  11. Preliminary Results to Support Evidence of Thermospheric Contraction

    NASA Astrophysics Data System (ADS)

    Saunders, A.; Swinerd, G.; Lewis, H.

    Atmospheric density has an important influence in predicting the positions of satellites in low Earth orbit. For long-term predictions of satellite ephemerides, any density trend in the thermosphere would be a valuable input, not only to satellite operators, but also to studies of the future low Earth orbit environment in terms of space debris. A secular thermospheric density trend has not yet been definitively proven but predictions by Ramesh and Roble [1], along with evidence by Emmert et al. [2], strongly suggest the existence of such a phenomenon. With the ultimate goal of deriving a long-term empirical model of thermospheric cooling and contraction, the primary focus of this paper is to present preliminary results obtained to support the existing evidence for such a thermospheric contraction. There are many ways of determining atmospheric density, but inferring thermospheric density from satellite drag data is a relatively cost-effective way of gathering in-situ measurements. Given an initial satellite orbit, one approach is to use an orbital propagator to predict the satellite's state at some time ahead and then to compare that state with Two-Line Element (TLE) data at the same epoch. The difference between the semi-major axis of the satellite from the initial orbit and that after the orbit propagation is then integrated to obtain an estimate of global average density. This is the approach adopted in our new work, using a bespoke, orbital propagator that includes perturbations due to atmospheric drag, gravitational anomalies, luni-solar gravity effects and solar radiation pressure. The methods used to derive precise estimates of the ballistic coefficient of each satellite for use in the propagator are outlined, as this information is not contained explicitly in the TLE sets. In validation of the orbital propagator used in this study, Saunders et al. [3] ran simulations to predict satellite re-entry dates with satisfactory results. Now, historical satellite

  12. Preliminary palaeoseismological results from the Kaparelli fault (Central Greece)

    NASA Astrophysics Data System (ADS)

    Pavlides, S.; Koukouvelas, I.; Ganas, A.; Kokkalas, S.; Tsodoulos, I.; Stamatopoulos, L.; Goyntromichou, C.; Valkaniotis, S.

    2003-04-01

    The roughly E-W trending Kaparelli-Plataees Fault is an on-shore normal fault segment located at the eastern end of the Gulf of Corinth Rift. The fault is a segment of the greater Plataees-Avlon fault zone (Beotia-Attica). It was activated during the third event of the February- March 1981 Alkyonides seismic sequence (Ms 6.7; 6.6; 6.4). The ground offset was 70cm, although some values of more than 1m have been reported too. The slip vector was 200-220 o/60-70 o (azimuth, rake). This presentation is a brief account of our efforts to search the seismic history and to resolve slip of the Kaparelli normal fault, in terms of trenching techniques, tectonostratigraphy of fault-related colluvial deposits and dating palaeoevents. Three (3) trenches have been excavated across the 1981 fault trace during May-June 2002. They are oriented perpendicular to the fault strike, and are located in Holocene deformed sediments (colluvium), in contact with bedrock limestone. Trenches have lengths of 15 to 30 m and depths of 2-4 m and their walls were mapped in scale 1:20. The KAP1 comprises a sequence of clay, sand, colluvial wedges and soil. In this trench the last (1981) event is clearly shown within a greater fault zone of 3m width. The hangingwall block of the reactivated fault strand during the 1981 event comprises a strongly rotated (>60o) sedimentary sequence corresponding with cumulative fault deformation. KAP2 and KAP3 trenches constitute of typical colluvium (unconsolidated angular limestone fragments and soil), which includes occasionaly tile fragments, some charcoal and pottery fragments. We have identified at least three (3) seismic events based on a) colluvium tectonostratigraphy mainly, b) deposition of sedimentary layers, c)formation of soil, and d) small displacement of few horizons. Although previous works have suggested that the fault was activated approximately 3 times during the last 20 ka years and remained quiet for 10 ka years our preliminary results from the

  13. [Temporary disability in operated spine patients. Preliminary report].

    PubMed

    Rodríguez-Cabrera, Rafael; Ruiz-García, Diana; Velázquez-Ramírez, Ismael

    2013-01-01

    The spinal injuries in workers have become a large scale health problem. The purpose of this study is to review the differences in the spine pathologies from incapacity to work, as well as factors that could alter the recovery time and the possibility of returning the patient to work. Statistical preliminary review study in 37 patients enrolled in the Instituto Mexicano del Seguro Social, workers, undertaken to spinal pathology surgery, comparing days of incapacity with proposed internationally, as well as his return to work. The results show that 37% of the patients studied are still active in the social security, 2 years after surgery. The days of disability generated by the pathology in this study group (212.3 days) are significantly higher than what is set on the Medical Disability Advisor (56 days, almost 4 times more). The study shows the need to develop the same analysis in other hospitals, comparing the proportion of cases that return to the work and total disability times for diagnostics.

  14. Preliminary results on the conversion of laser energy into electricity

    NASA Technical Reports Server (NTRS)

    Thompson, R. W.; Manista, E. J.; Alger, D. L.

    1978-01-01

    A preliminary experiment was performed to investigate conversion of 10.6 micron laser energy to electrical energy via a laser-sustained argon plasma. Short-circuit currents of 0.7 A were measured between a thoriated-tungsten emitter and collector electrodes immersed in the laser-sustained argon plasma. Open-circuit voltages of about 1.5 V were inferred from the current-voltage load characteristics. The dominant mechanism of laser energy conversion is uncertain at this time. Much higher output powers appear possible.

  15. Optical scattering (TAOS) by tire debris particles: preliminary results

    NASA Astrophysics Data System (ADS)

    Crosta, Giovanni F.; Camatini, Marina C.; Zomer, Simeone; Holler, Stephen; Pan, Yongle; Bhaskara, Praveena; Muangchareon, Pongphisanu; Sung, Changmo; Cencetti, Simone; Regazzoni, Claudia

    2001-03-01

    Tire debris particles from low severity laboratory wear tests have been investigated by the TAOS optical scattering facility at Yale University. The incident wavelength is 532 nm. After the TAOS event some particle samples have been imaged by a scanning electron microscope and microanalyzed. The TAOS intensity patterns recorded within a solid angle in the backward sector have been processed by cluster analysis and compared with the patterns computed by a T-matrix code. Preliminary agreement has been found between TAOS data and the particle models (size, shape, refractive index). The purpose of the investigation is to obtain signatures of the material, based on its TAOS pattern.

  16. Optical scattering (TAOS) by tire debris particles: preliminary results.

    PubMed

    Crosta, G; Camatini, M; Zomer, S; Holler, S; Pan, Y; Bhaskara, P; Muangchareon, P; Sung, C; Cencetti, S; Regazzoni, C

    2001-03-12

    Tire debris particles from low severity laboratory wear tests have been investigated by the TAOS optical scattering facility at Yale University. The incident wavelength is 532 nm. After the TAOS event some particle samples have been imaged by a scanning electron microscope and microanalyzed. The TAOS intensity patterns recorded within a solid angle in the backward sector have been processed by cluster analysis and compared with the patterns computed by a T-matrix code. Preliminary agreement has been found between TAOS data and the particle models (size, shape, refractive index). The purpose of the investigation is to obtain signatures of the material, based on its TAOS pattern.

  17. Preliminary results on the conversion of laser energy into electricity

    NASA Technical Reports Server (NTRS)

    Thompson, R. W.; Manista, E. J.; Alger, D. L.

    1978-01-01

    A preliminary experiment was performed to investigate conversion of 10.6 micron laser energy to electrical energy via a laser-sustained argon plasma. Short-circuit currents of 0.7 A were measured between a thoriated-tungsten emitter and collector electrodes immersed in the laser-sustained argon plasma. Open-circuit voltages of about 1.5 V were inferred from the current-voltage load characteristics. The dominant mechanism of laser energy conversion is uncertain at this time. Much higher output powers appear possible.

  18. CALAS: Carpathian laser strainmeter: a project and preliminary results

    NASA Astrophysics Data System (ADS)

    Garoi, F.; Apostol, D.; Damian, V.; Logofătu, P. C.; Ioniţă, B. F.; Lazar, J.; Molesini, G.; Papadopoulos, T.; Ionescu, C.; Ţugui, Andreea

    2008-06-01

    A laser strainmeter for in-situ monitoring of an important actively seismic area of Europe, namely Vrancea region in Romania is proposed. Six groups from four different countries (Romania, Czech Republic, Italy and Greece) with various areas of expertise (e.g. geophysics, lasers, optics, interferometry, and mechanics) are involved in order to sustain the complexity of the project. This paper presents some preliminary laboratory experiments related to measuring relative displacements with a stable interferometer. Displacements of the order of tens to hundreds of nanometers (80 to 285 nm) were measured with uncertainty of +/-1 nm. A computer algorithm was used to process the interferograms.

  19. Experimental Studies of Ion Beam Neutralization: Preliminary Results

    SciTech Connect

    Ding, N.; Polansky, J.; Downey, R.; Wang, J.

    2011-05-20

    A testing platform is designed to study ion beam neutralization in the mesothermal, collisionless region. In the experimental setup, argon neutrals were ionized in a microwave cavity and accelerated by a plasma lens system which was biased to 2500 V above the system ground. Electrons were boiled off from two hot tungsten filaments to neutralize the ion beam. The plasma is diagnosed using Langmuir probe and Faraday probe. A 3-D traversing system and a complete data acquisition loop were developed to efficiently measure 3-D beam profile. Preliminary measurements of beam profiles are presented for different operating conditions.

  20. 76 FR 66903 - Steel Wire Garment Hangers From the People's Republic of China: Preliminary Results and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Results and Preliminary Rescission, in Part, of the Second Antidumping Duty Administrative Review AGENCY... Department of Commerce (``Department'') is conducting the second administrative review of steel wire garment...'') by the respondent. If these preliminary results are adopted in our final results of this review,...

  1. Paleomagnetic dating of ferricretes in New Caledonia. Preliminary results.

    NASA Astrophysics Data System (ADS)

    Sevin, Brice; Ricordel-Prognon, Caroline; Quesnel, Florence; Cluzel, Dominique; Maurizot, Pierre; Robineau, Bernard

    2010-05-01

    Although the description of the emplacement (Cluzel et al., 2001) and the weathering (Trescases, 1975; Latham, 1986; Chevillotte et al., 2006) of the New Caledonia peridotites is well documented in the literature, the knowledge and the age of formation of the landsurfaces formed upon the ultrabasic massifs are poorly documented. Several surfaces have been recognised along the island but no reliable ages could be attributed to the associated regolith. In fact, the overthrust of the Ophiolitic Nappe in the South is stratigraphically constrained by a younger autochthonous olistostrom dated by Late Priabonian pelagic foraminifera (Cluzel et al., 1998). The supergene weathering being still active, the beginning of the ferruginisation of the various plateaux is not well constrained and estimated to have occurred between 34 Ma and Actual. The processes of absolute dating are not relevant to these weathering profiles (K-Mn oxides are poorly concentrated). Ferricretes and various ferruginous materials have the potential to record the ancient geomagnetic field providing means of age determination. In tropical soils, most of the primary remanence carring minerals are dissolved during weathering and secondary magnetic minerals, such as goethite and haematite, are formed in situ acquiring a crystallisation (or chemical) remanent magnetization (CRM). The paleomagnetic pole recovered by demagnetizing the CRMs are plotted on the local apparent polar wandering (APWP) reference curve providing an age for the different parts of the paleoweathering profiles. The data and interpretations we present here are based on paleomagnetic analysis of ferricretes of Goro and Tiebaghi. The preliminary results suggest, for the first time ever, well constrained ages between 20 and 25 Ma of major ferruginisation stages of the peridotites of New Caledonia. References Chevillotte V., Chardon D., Beauvais A, Maurizot P. & Colin F. (2006). Long-term tropical morphogenesis of New Caledonia (Southwest

  2. [Ultra-fast opiate detoxification under general anesthesia: preliminary results of the Liege protocol].

    PubMed

    Pinto, E; Reggers, J; Delhez, M; Fuchs, S; Venneman, I; Lamy, M; Ansseau, M

    2001-08-01

    Many studies support the hypothesis of a substantial benefit in inducing an Opiate Receptor Blockade through a Rapid Opiate Detoxification under general Anaesthesia (RODA) in opiate dependent patients. However, prospective studies and long term evaluation of the technique are lacking. In order to evaluate long-term abstinence rates after a RODA among a sample of opiate addicts, a study was started in March 1999 at the University of Liège. To date, 45 patients were evaluated (mean age: 29 +/- 5 years) with a mean opiate dependence duration of 8 +/- 4 years. Most of them were both heroin and methadone dependent; 42.2% of them were included while 31.1% did not complete the whole inclusion procedure and 26.7% were excluded. None experienced severe withdrawal symptoms. At six months, abstinence rate was 67% and 46% at one year. These preliminary results suggest the interest of the procedure in carefully selected patients.

  3. Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial.

    PubMed

    Galante, E; Venturini, G; Fiaccadori, C

    2007-01-01

    Dementia is a highly invalidating condition and, given the progressive aging of the population, one of the major issues that health systems will have to face in future years. Recently there has been an increase in the potential of diagnostic tools and pharmacological treatments for dementia; moreover, considerable interest has been expressed regarding non pharmacological interventions. However, the current evidence in support of non pharmacological treatments in patients affected by dementia still does not allow to draw definitive conclusions on what is the most effective treatment to apply, largely because of methodological difficulties and limitations of the studies so far carried out due to the complex nature of the disease. To address this need, we carried out a single blind randomized controlled study on the efficacy of computer cognitive rehabilitation in patients with mild cognitive decline. We here present preliminary data on 11 patients with diagnosis of Alzheimer's Disease (AD) and mild cognitive decline randomly assigned to treatment (a) or control (b) condition (i.e. specific vs. aspecific treatment). The specific treatment (a) consisted in a cycle of 12 individual sessions of computer exercises, while the control condition (b) consisted in sessions of semi-structured interviews with patients, conducted with the same frequency and time period as (a). Cognitive, behavioural and functional assessment was performed by an expert evaluator, blinded to the patients' group allocation. Preliminary results show a significant performance decline only in the control group at the 9-month follow-up compared to both baseline and the 3-month follow-up. Our results suggest that computer based cognitive training in patients with AD and mild cognitive decline is effective at least in delaying the continuous progression of cognitive impairment in AD.

  4. Magnetic resonance imaging of aortic disease: preliminary results

    SciTech Connect

    Amparo, E.G.; Higgins, C.B.; Hoddick, W.; Hricak, H.; Kerlan, R.K.; Ring, E.J.; Kaufman, L.; Hedgecock, M.W.

    1984-12-01

    Fourteen patients with a variety of aortic diseases were evaluated with magnetic resonance imaging (MRI). These included abdominal aortic aneurysms (eight cases), aortoiliac aneurysm (one), thoracoabdominal aneurysm (one), aortic dissections (four), and Takayasu arteritis (one). The size and extent of aneurysms, the presence of thrombus or atherosclerotic debris, the relation to renal and iliac arteries, and the effect of aneurysms on adjacent structures were readily demonstrated by MRI. The size of the residual lumen in a variety of vascular diseases and abnormal blood flow patterns could be assessed. These early results indicated that MRI achieved precise and complete assessment of a number of aortic abnormalities without the administration of any type of contrast material. Thus, early experience suggests that an important application of MRI will be as a totally noninvasive and reliable method for evaluating aortic disease.

  5. Preliminary Results of Femtosecond Laser-assisted Cataract Surgery in a Private Clinic in Iran

    PubMed Central

    Nejat, Farhad; Sarahati, Sara; Nobari, Sahar Mojaled; Jadidi, Khosrow; Naderi, Mostafa; Nejat, Mohammad Amin

    2017-01-01

    Purpose: To report the preliminary results of femtosecond laser-assisted cataract surgery in Iranian patients. Methods: This prospective case series included 21 eyes of 21 patients with cataract. Mean patient age was 66.7 ± 10 years. The patients underwent femtosecond-laser assisted cataract surgery (VICTUS Femtosecond Laser Platform: Bausch + Lomb) and intraocular lens (IOL) implementation in Bina Eye Hospital, Tehran, Iran between May and October, 2014. Visual outcomes, intraocular pressure (IOP), and complications were evaluated three months after surgery. Results: Mean preoperative best-spectacle corrected visual acuity (BSCVA) was 0.40 ± 0.21 logMAR which significantly improved to 0.02 ± 0.03 logMAR three months postoperatively (P < 0.001). Mean preoperative IOP was 17.88 ± 2.70 mmHg which significantly decreased to 12.5 ± 1.51 mmHg three months after operation (P < 0.001). Mean duration of operation for these patients was 29.30 ± 8 minutes and mean femtosecond laser process time was 4.20 ± 2 minutes. In terms of complications, 9 patients developed fine subconjunctival hemorrhage and eye redness and 2 patients had mild corneal edema which all subsided within less than 7 days. Serious complications such as anterior or posterior capsule tears were not encountered. Conclusion: Femtosecond laser-assisted cataract surgery is a relatively new method of cataract PMID:28299005

  6. 71 FR 67850 - Honey From Argentina: Preliminary Results of New Shipper Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2006-11-24

    ... International Trade Administration Honey From Argentina: Preliminary Results of New Shipper Review AGENCY...) is conducting a new shipper review of the antidumping order of honey from Argentina. The period of... the case of sales of honey from Argentina from Patagonik. If these preliminary results are adopted...

  7. 78 FR 77651 - Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... International Trade Administration Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of... refined copper pipe and tube from Mexico.\\1\\ The review covers two producers/ exporters of the subject... are invited to comment on these preliminary results. \\1\\ See Seamless Refined Copper Pipe and...

  8. Preliminary results of the trapped atom clock on a chip.

    PubMed

    Lacroute, Clement; Reinhard, Friedemann; Ramirez-Martinez, Fernando; Deutsch, Christian; Schneider, Tobias; Reichel, Jakob; Rosenbusch, Peter

    2010-01-01

    We present an atomic clock based on the interrogation of magnetically trapped (87)Rb atoms. Two photons, in the microwave and radiofrequency domain, excite the clock transition. At a magnetic field of 3.23 G the clock transition from |F = 1, m(F) = -1> to |F = 2, m(F) = 1> is 1st-order insensitive to magnetic field variations. Ramsey interrogation times longer than 2 s can be achieved, leading to a projected clock stability in the low 10(-13) at 1 s for a cloud of 10(5) atoms. We use an atom chip to cool and trap the atoms. A coplanar waveguide is integrated to the chip to carry the Ramsey interrogation signal, making the physics package as small as (5 cm)(3). We describe the experimental setup and show preliminary Ramsey fringes of line width 1.25 Hz.

  9. Preliminary Results of the Extreme Ultraviolet Explorer Right Angle Program

    NASA Astrophysics Data System (ADS)

    McDonald, K.; Craig, N.; Sirk, M. M.; Drake, J. J.; Malina, R. F.

    1993-12-01

    During the guest observer phase of the EUVE Mission, data are being collected with the survey scanners and the Deep Survey Scanner. The EUVE Right Angle Program (RAP) involves the analysis of this data set and the coordination of possible simultaneous observations with ground based instruments. This data set consists of several discrete pointings performed at a much deeper level than the previous EUVE all-sky survey, although covering only a few percent of the sky. Analysis of this data set has detected a large number of previously undetected EUV sources. We present here a preliminary list of the sources observed during the EUVE Right Angle Program and compare properties of this list with properties of the EUVE Bright Source List. This work has been supported by NASA contract NAS5--30180.

  10. Preliminary Results on Lunar Interior Properties from the GRAIL Mission

    NASA Technical Reports Server (NTRS)

    Williams, James G.; Konopliv, Alexander S.; Asmar, Sami W.; Lemoine, H. Jay; Melosh, H. Jay; Neumann, Gregory A.; Phillips, Roger J.; Smith, David E.; Solomon, Sean C.; Watkins, Michael M.; Wieczorek, Mark A.; Zuber, Maria T.; Andrews-Hanna, Jeffrey C.; Head, James W.; Kiefer, Walter S.; Matsuyama, Isamu; McGovern, Patrick J.; Nimmo, Francis; Weber, Renee C.; Boggs, D. H.; Goossens, Sander J.; Kruizinga, Gerhard L.; Mazarico, Erwan; Park, Ryan S.; Yuan, Dah-Ning

    2013-01-01

    The Gravity Recovery and Interior Laboratory (GRAIL) mission has provided lunar gravity with unprecedented accuracy and resolution. GRAIL has produced a high-resolution map of the lunar gravity field while also determining tidal response. We present the latest gravity field solution and its preliminary implications for the Moon's interior structure, exploring properties such as the mean density, moment of inertia of the solid Moon, and tidal potential Love number k2. Lunar structure includes a thin crust, a deep mantle, a fluid core, and a suspected solid inner core. An accurate Love number mainly improves knowledge of the fluid core and deep mantle. In the future GRAIL will search for evidence of tidal dissipation and a solid inner core.

  11. Intra-Operative Lymphatic Mapping and Sentinel Node Biopsy in Laryngeal Carcinoma: Preliminary Results

    PubMed Central

    Khadivi, Ehsan; Daghighi, Maryam; Khazaeni, Kamran; Dabbagh Kakhki, Vahid Reza; Zarifmahmoudi, Leili; Sadeghi, Ramin

    2015-01-01

    Introduction: Sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far. In the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer. Materials and Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included in the study. Two mCi/0.4 cc Tc-99m-phytate in four aliquots was injected on the day of surgery, after induction of anesthesia, in the sub-mucosal peri-tumoral location using a suspension laryngoscopy. After waiting for 10 minutes, a portable gamma probe was used to search for sentinel nodes. All patients underwent laryngectomy and modified radical bilateral neck dissection. All sentinel nodes and removed non-sentinel nodes were examined by hematoxylin and eosin (H&E) staining. Results: Ten patients with laryngeal carcinoma were included. At least one sentinel node could be detected in five patients (bilateral nodes in four patients). One patient had pathologically involved sentinel and non-sentinel nodes (no false-negative cases). Conclusion: Sentinel node mapping in laryngeal carcinoma is technically feasible using an intra-operative radiotracer injection. In order to evaluate the relationship of T-stage and the laterality of the tumor with accuracy, larger studies are needed. PMID:26788477

  12. Diode laser supported partial nephrectomy in laparoscopic surgery: preliminary results

    NASA Astrophysics Data System (ADS)

    Sroka, Ronald; Hennig, Georg; Zillinberg, Katja; Khoder, Wael Y.

    2011-07-01

    Introduction: Warm ischemia and bleeding during laparoscopic partial nephrectomy place technical constraints on surgeons. Therefore it was the aim to develop a safe and effective laser assisted partial nephrectomy technique without need for ischemia. Patients and methods: A diode laser emitting light at 1318nm in cw mode was coupled into a bare fibre (core diameter 600 μm) thus able to transfer up to 100W to the tissue. After dry lab experience, a total of 8 patients suffering from kidney malformations underwent laparoscopic/retroperitoneoscopic partial nephrectomy. Clinically, postoperative renal function and serum c-reactive protein (CRP) were monitored. Laser induced coagulation depth and effects on resection margins were evaluated. Demographic, clinical and follow-up data are presented. Results: Overall interventions, the mean operative time was 116,5 minutes (range 60-175min) with mean blood loss of 238ml (range 50-600ml) while laser assisted resection of the kidney tissue took max 15min. After extirpation of the tumours all patients showed clinical favourable outcome during follow up period. The tumour size was measured to be 1.8 to 5cm. With respect to clinical safety and due to blood loos, two warm ischemia (19 and 24min) must be performed. Immediate postoperative serum creatinine and CRP were elevated within 0.1 to 0.6 mg/dl (mean 0.18 mg/dl) and 2.1-10 mg/dl (mean 6.24 mg/dl), respectively. The depth of the coagulation on the removed tissue ranged between <1 to 2mm without effect on histopathological evaluation of tumours or resection margin. As the surface of the remaining kidney surface was laser assisted coagulated after removal. The sealing of the surface was induced by a slightly larger coagulation margin, but could not measured so far. Conclusion: This prospective in-vivo feasibility study shows that 1318nm-diode laser assisted partial nephrectomy seems to be a safe and promising medical technique which could be provided either during open surgery

  13. Adaptive sound speed correction for abdominal ultrasonography: preliminary results

    NASA Astrophysics Data System (ADS)

    Jin, Sungmin; Kang, Jeeun; Song, Tai-Kyung; Yoo, Yangmo

    2013-03-01

    Ultrasonography has been conducting a critical role in assessing abdominal disorders due to its noninvasive, real-time, low cost, and deep penetrating capabilities. However, for imaging obese patients with a thick fat layer, it is challenging to achieve appropriate image quality with a conventional beamforming (CON) method due to phase aberration caused by the difference between sound speeds (e.g., 1580 and 1450m/s for liver and fat, respectively). For this, various sound speed correction (SSC) methods that estimate the accumulated sound speed for a region-of interest (ROI) have been previously proposed. However, with the SSC methods, the improvement in image quality was limited only for a specific depth of ROI. In this paper, we present the adaptive sound speed correction (ASSC) method, which can enhance the image quality for whole depths by using estimated sound speeds from two different depths in the lower layer. Since these accumulated sound speeds contain the respective contributions of layers, an optimal sound speed for each depth can be estimated by solving contribution equations. To evaluate the proposed method, the phantom study was conducted with pre-beamformed radio-frequency (RF) data acquired with a SonixTouch research package (Ultrasonix Corp., Canada) with linear and convex probes from the gel pad-stacked tissue mimicking phantom (Parker Lab. Inc., USA and Model539, ATS, USA) whose sound speeds are 1610 and 1450m/s, respectively. From the study, compared to the CON and SSC methods, the ASSC method showed the improved spatial resolution and information entropy contrast (IEC) for convex and linear array transducers, respectively. These results indicate that the ASSC method can be applied for enhancing image quality when imaging obese patients in abdominal ultrasonography.

  14. No Detectable Hypoxia in Malignant Salivary Gland Tumors: Preliminary Results

    SciTech Connect

    Wijffels, Karien; Hoogsteen, Ilse J.; Lok, Jasper; Rijken, Paulus F.J.W.; Marres, Henri A.M.; Wilde, Peter C.M. de; Kogel, Albert J. van der; Kaanders, Johannes H.A.M.

    2009-04-01

    Purpose: Hypoxia is detected in most solid tumors and is associated with malignant progression and adverse treatment outcomes. However, the oxygenation status of malignant salivary gland tumors has not been previously studied. The aim of this study was to investigate the potential clinical relevance of hypoxia in this tumor type. Methods and Materials: Twelve patients scheduled for surgical resection of a salivary gland tumor were preoperatively injected with the hypoxia marker pimonidazole and the proliferation marker iododeoxyuridine. Tissue samples of the dissected tumor were immunohistochemically stained for blood vessels, pimonidazole, carbonic anhydrase-IX, glucose transporters-1 and -3 (Glut-1, Glut-3), hypoxia-inducible factor-1{alpha}, iododeoxyuridine, and epidermal growth factor receptor. The tissue sections were quantitatively assessed by computerized image analysis. Results: The tissue material from 8 patients was of sufficient quality for quantitative analysis. All tumors were negative for pimonidazole binding, as well as for carbonic anhydrase-IX, Glut-1, Glut-3, and hypoxia-inducible factor-1{alpha}. The vascular density was high, with a median value of 285 mm{sup -2} (range, 209-546). The iododeoxyuridine-labeling index varied from <0.1% to 12.2% (median, 2.2%). Epidermal growth factor receptor expression levels were mostly moderate to high. In one-half of the cases, nuclear expression of epidermal growth factor receptor was observed. Conclusion: The absence of detectable pimonidazole binding, as well as the lack of expression of hypoxia-associated proteins in all tumors, indicates that malignant salivary gland tumors are generally well oxygenated. It is unlikely that hypoxia is a relevant factor for their clinical behavior and treatment responsiveness.

  15. [Endonasal and endocanalicular dacryocystorhinostomy by diode laser. Preliminary results].

    PubMed

    Alañón Fernández, M A; Alañón Fernández, F J; Martínez Fernández, A; Cárdenas Lara, M; Rodríguez Domínguez, R; Ballesteros Navarro, J M; Sainz Quevedo, M

    2004-04-01

    To describe the surgical technique and to evaluate the clinical results after having performed the transcanalicular and endocanalicular dacryocystorhinostomies by diode laser, including the advantages and limits of this technique. 34 were performed by diode laser in patients with clinical history of epiphora, with or without mucopurulent secretion, for nasolacrimal duct obstruction. The study was prospective, interventional, non randomized and non comparative. Diode laser was used to realize vaporization of lacrimal sac, osteotomy and vaporization with coagulation of nasal mucosa. The mean of surgical time was 15 minutes (range 7 to 29 minutes). Bicanalicular intubation was performed with a silicone tube and prolene filament for two months in all cases. Postsurgical follow-up was between 4 and 11 months. The degree of epiphora was evaluated by the Munk scale and lacrimal permeability was evaluated by endoscopic functional staining test in all cases. Out of the 34 DCR-EDN+ENC that were performed, 32 cases (94.11%) remain asymptomatic. Two of them (5.88%) required endonasal dacryocystorhinostomies by drilling, because the bony perforation was impossible to achieve by laser fiber. Two cases (5.88%) presented fibrosis and lacrimal and lower canaliculi obstruction, without epiphora because the superior canaliculi was permeable. Endonasal and endocanalicular dacryocystorhinostomy technique performed by diode laser is a valid method. It does not cause cutaneous scarring, it decreases thermic canalicular damage, it respects the lacrimal pump, it minimizes pain and bleeding, it needs less surgical time and it has turned into an out-patient procedure with a minimal surgical and postsurgical morbility.

  16. Preliminary results from the new HIV surveillance system in France.

    PubMed

    Lot, F; Semaille, C; Cazein, F; Barin, F; Pinget, R; Pillonel, J; Desenclos, J C

    2004-10-01

    In addition to AIDS surveillance, data on HIV infection are necessary to better follow the dynamics of the epidemic. We report the first results of France's mandatory anonymous HIV notification system, which is linked to a virological surveillance of recent HIV infections and of circulating HIV types, groups and subtypes. HIV notifications are initiated by microbiologists who create an anonymous code of patient's identity. Clinicians complete the notification form with epidemiological and clinical data. Notifications are sent to the local health authorities and passed to the Institut de Veille Sanitaire (InVS). Laboratories voluntarily send sera from newly diagnosed HIV infected persons on dried blood spots to the national HIV reference laboratory where an immunoassay for recent infection (< or = 6 months) and a serotyping assay for the determination of group and subtype are done. The virological results are then merged at the InVS with the information from the mandatory reporting. Of the first 1301 new HIV diagnoses reported in 2003, 43% were in women, and overall, 53% were in heterosexuals, of whom 47% were of sub-Saharan African origin. MSM accounted for 36% of male notifications. A dried blood spot was available for 64% of new HIV diagnoses. Evidence of recent infection was found for 38%, ranging from 22% in IDUs to 58% in MSM. Twenty-six percent of infections in sub-Saharan migrants were recent infections. HIV-1 accounted for 98% of all notifications: 48% of these were non-B subtypes. The first results of the HIV notification system indicate that heterosexual transmission is the predominant mode of transmission and that persons originating from sub-Saharan Africa are particularly affected. Over half of infections shown to be recently acquired were in MSM; this may indicate an increased HIV incidence in this population.

  17. Percutaneous peritoneovenous shunt positioning: technique and preliminary results.

    PubMed

    Orsi, Franco; Grasso, Rosario Francesco; Bonomo, Guido; Monti, Cinzia; Marinucci, Irene; Bellomi, Massimo

    2002-05-01

    Nine peritoneovenous shunts were positioned by percutaneous technique in seven patients with advanced malignancy causing severe refractory ascites, and in two patients with hepatic cirrhosis (one with hepatocarcinoma). In all patients the shunts were percutaneously placed through the subclavian vein in the angiographic suite under digital fluoroscopic guide. No complications directly related to the procedure occurred. The shunt was successfully positioned in all patients in 60 min average time. No patient showed symptoms related to pulmonary overload or to disseminated intravascular coagulation. All patients had a significant improvement of the objective symptoms related to ascites such as respiratory symptoms, dyspepsia, and functional impairment to evacuation describing an improvement of their quality of life. Maximum shunt patency was 273 days. Percutaneous placement of peritoneovenous shunt is a safe, fast, and inexpensive procedure, extremely useful in resolution of refractory ascites, reducing symptoms, and allowing effective palliation, with a great improvement in quality of life.

  18. Electromagnetic-Tracked Biopsy under Ultrasound Guidance: Preliminary Results

    SciTech Connect

    Hakime, Antoine Deschamps, Frederic; Marques De Carvalho, Enio Garcia; Barah, Ali; Auperin, Anne; Baere, Thierry De

    2012-08-15

    Purpose: This study was designed to evaluate the accuracy and safety of electromagnetic needle tracking for sonographically guided percutaneous liver biopsies. Methods: We performed 23 consecutive ultrasound-guided liver biopsies for liver nodules with an electromagnetic tracking of the needle. A sensor placed at the tip of a sterile stylet (18G) inserted in a coaxial guiding trocar (16G) used for biopsy was localized in real time relative to the ultrasound imaging plane, thanks to an electromagnetic transmitter and two sensors on the ultrasound probe. This allows for electronic display of the needle tip location and the future needle path overlaid on the real-time ultrasound image. Distance between needle tip position and its electronic display, number of needle punctures, number of needle pull backs for redirection, technical success (needle positioned in the target), diagnostic success (correct histopathology result), procedure time, and complication were evaluated according to lesion sizes, depth and location, operator experience, and 'in-plane' or 'out-of-plane' needle approach. Results: Electronic display was always within 2 mm from the real position of the needle tip. The technical success rate was 100%. A single needle puncture without repuncture was used in all patients. Pull backs were necessary in six patients (26%) to obtain correct needle placement. The overall diagnostic success rate was 91%. The overall true-positive, true-negative, false-negative, and failure rates of the biopsy were 100% (19/19) 100% (2/2), 0% (0/23), and 9% (2/23). The median total procedure time from the skin puncture to the needle in the target was 30 sec (from 5-60 s). Lesion depth and localizations, operator experience, in-plane or out-of-plane approach did not affect significantly the technical, diagnostic success, or procedure time. Even when the tumor size decreased, the procedure time did not increase. Conclusions: Electromagnetic-tracked biopsy is accurate to determine

  19. Seismic Hazard Maps for the Maltese Archipelago: Preliminary Results

    NASA Astrophysics Data System (ADS)

    D'Amico, S.; Panzera, F.; Galea, P. M.

    2013-12-01

    The Maltese islands form an archipelago of three major islands lying in the Sicily channel at about 140 km south of Sicily and 300 km north of Libya. So far very few investigations have been carried out on seismicity around the Maltese islands and no maps of seismic hazard for the archipelago are available. Assessing the seismic hazard for the region is currently of prime interest for the near-future development of industrial and touristic facilities as well as for urban expansion. A culture of seismic risk awareness has never really been developed in the country, and the public perception is that the islands are relatively safe, and that any earthquake phenomena are mild and infrequent. However, the Archipelago has been struck by several moderate/large events. Although recent constructions of a certain structural and strategic importance have been built according to high engineering standards, the same probably cannot be said for all residential buildings, many higher than 3 storeys, which have mushroomed rapidly in recent years. Such buildings are mostly of unreinforced masonry, with heavy concrete floor slabs, which are known to be highly vulnerable to even moderate ground shaking. We can surely state that in this context planning and design should be based on available national hazard maps. Unfortunately, these kinds of maps are not available for the Maltese islands. In this paper we attempt to compute a first and preliminary probabilistic seismic hazard assessment of the Maltese islands in terms of Peak Ground Acceleration (PGA) and Spectral Acceleration (SA) at different periods. Seismic hazard has been computed using the Esteva-Cornell (1968) approach which is the most widely utilized probabilistic method. It is a zone-dependent approach: seismotectonic and geological data are used coupled with earthquake catalogues to identify seismogenic zones within which earthquakes occur at certain rates. Therefore the earthquake catalogues can be reduced to the

  20. The force module for the bending art system. Preliminary results.

    PubMed

    Fischer-Brandies, H; Orthuber, W; Ermert, M; Hussmanns, A

    1998-01-01

    The force module for the bending art system (BAS) is used to calculate the initial forces and moments expected to act on a tooth after changing arch wires. The present study analyses the accuracy of the force module on the basis of 10 patients treated with the BAS (with an average observation period of 10 months). An average of 6 arch wires (0.16" x 0.016" steel) were used on each jaw. The approximate pressure in the periodontium was determined and statistically evaluated from the force module readings. The resulting average pressure values for the molars ranged between 0.26 N/cm2 and 0.54 N/cm2. The value in the area of the incisors, cuspids and bicuspids ranged between 1.03 N/cm2 and 2.83 N/cm2. Maximum pressure was 8.02 N/cm2. The results are discussed from a clinical point of view on a case-to-case basis. They are plausible in and for themselves. The more severe the initial state of misalignment, the higher the pressure values. These forces can be reduced by increasing the number of arch wires or by altering the form of the archwire correspondingly. The computer-generated values should be confirmed by taking a direct measurement on the tooth. The force module is just the first step in providing a reproducible estimation of the forces acting on a tooth. Even if the calculated absolute values should still be judged with reservation, they are nevertheless suitable for providing a comparative evaluation of various treatment concepts with reference to the forces acting on the periodontium and can serve clinicians as a rapidly available decision-making aid.

  1. 78 FR 7395 - Stainless Steel Bar From India: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... International Trade Administration Stainless Steel Bar From India: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from India. The period of review (POR) is... Review: Stainless Steel Bar from India'' dated concurrently with this notice (``Preliminary...

  2. 75 FR 39207 - Purified Carboxymethylcellulose From Finland: Extension of Time Limit for Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... International Trade Administration Purified Carboxymethylcellulose From Finland: Extension of Time Limit for... 30, 2010. See Purified Carboxymethylcellulose From Finland: Extension of Time Limit for Preliminary... Time Limits for Preliminary Results Section 751(a)(3)(A) of the Tariff Act of 1930, as amended (the Act...

  3. Prepectoral Implant-Based Breast Reconstruction: Rationale, Indications, and Preliminary Results.

    PubMed

    Sigalove, Steven; Maxwell, G Patrick; Sigalove, Noemi M; Storm-Dickerson, Toni L; Pope, Nicole; Rice, Jami; Gabriel, Allen

    2017-02-01

    Implant-based breast reconstruction is currently performed with placement of the implant in a subpectoral pocket beneath the pectoralis major muscle, by means of the dual-plane approach. Although the safety and breast aesthetics of this approach are well recognized, it is not without concerns. Animation deformities and accompanying patient discomfort, which are direct consequences of muscle elevation, can be severe in some patients. Moving the implant prepectorally may eliminate these concerns. For a successful prepectoral approach, the authors advocate use of their bioengineered breast concept, which was detailed in a previous publication. In this report, the authors discuss the rationale for prepectoral implant reconstruction, its indications/contraindications, and preliminary results from over 350 reconstructions.

  4. Annoyance Caused by Propeller Airplane Flyover Noise: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Mccurdy, D. A.; Powell, C. A.

    1981-01-01

    The annoyance response of people to the noise of propeller airplane flyovers was examined. The specific items of interest were: (1) the annoyance prediction ability of current noise metrics; (2) the effect of tone corrections on prediction ability; (3) the effect of duration corrections on prediction ability; and (4) the effect of 'critical band' corrections on the prediction ability of perceived noise level. Preliminary analyses of the data obtained from two experiments are presented. The first experiment examined 11 propeller airplanes with maximum takeoff weights greater than or equal to 5700 kg. The second experiment examined 14 propeller airplanes weighting 5700 kg or less. Also included in each experiment were five different commercial service jet airplanes. Each airplane noise was presented at D-weighted sound pressure levels of 70, 80, and 90 dB to subjects in a testing room which simulates the outdoor acoustic environment. Subjects judged 108 stimuli in the first experiment and 132 stimuli in the second experiment. Perceived noise level predicted annoyance better than A, D, or E-weighted sound pressure level. Corrections for tones greater than of equal to 500 Hz generally improved prediction ability for the heavier propeller airplanes.

  5. WISE/NEOWISE OBSERVATIONS OF THE HILDA POPULATION: PRELIMINARY RESULTS

    SciTech Connect

    Grav, T.; Mainzer, A. K.; Bauer, J.; Masiero, J.; Eisenhardt, P. R.; Blauvelt, E.; DeBaun, E.; Elsbury, D.; Gautier, T.; Gomillion, S.; Hand, E.; Wilkins, A.; Spahr, T.; McMillan, R. S.; Walker, R.; Cutri, R.; Wright, E.

    2012-01-10

    We present the preliminary analysis of 1023 known asteroids in the Hilda region of the solar system observed by the NEOWISE component of the Wide-field Infrared Survey Explorer (WISE). The sizes of the Hildas observed range from {approx}3 to 200 km. We find no size-albedo dependency as reported by other projects. The albedos of our sample are low, with a weighted mean value of p{sub V} = 0.055 {+-} 0.018, for all sizes sampled by the NEOWISE survey. We observed a significant fraction of the objects in the two known collisional families in the Hilda population. It is found that the Hilda collisional family is brighter, with a weighted mean albedo of p{sub V} = 0.061 {+-} 0.011, than the general population and dominated by D-type asteroids, while the Schubart collisional family is darker, with a weighted mean albedo of p{sub V} = 0.039 {+-} 0.013. Using the reflected sunlight in the two shortest WISE bandpasses, we are able to derive a method for taxonomic classification of {approx}10% of the Hildas detected in the NEOWISE survey. For the Hildas with diameter larger than 30 km, there are 67{sup +7}{sub -15}% D-type asteroids and 26{sup +17}{sub -5%} C-/P-type asteroids (with the majority of these being P-types).

  6. Preliminary results of a computerized Placido disk surgical corneal topographer

    NASA Astrophysics Data System (ADS)

    Carvalho, Luis A.; Tonissi, S. A.; Castro, Jarbas C.

    1999-06-01

    We have developed a novel instrument for computerized corneal topography during surgery. The instrument measures a region of approximately 7 mm in diameter, providing the surgeon with precise values of power and astigmatism. The system is based on a Placido Disc projecting system, which is attached to the objective lens of the surgical microscope. The Placido Disc pattern is reflected by a 50% beam splitter attached to the body of the microscope. At the beam splitter we installed our home-made adaptor and a CCD monochromatic high resolution camera. A high quality frame grabber is installed on a PC and images are digitized at a 480x640 resolution. Algorithms based on image processing techniques were implemented for edge detection of pattern. Calibrating curves based on 4 spherical surfaces were generated and approximately 3600 points were calculated for each exam. Preliminary measurements on 10 healthy corneas were compared with the measurements made on an EyeSys Corneal Topographer. Mean deviation was 0.05 for radius of curvature, 0.24 D for power and 5 degrees for cylinder. This system, with some improvements, may be successfully used to diminish high post surgical astigmatisms in surgeries such as cataract and corneal transplant. This system could also be used to gather preoperative data in corneal topography assisted LASIK.

  7. Tropical Atlantic wind field variations during sequal: Preliminary results

    NASA Astrophysics Data System (ADS)

    Harrison, D. E.; Cardone, Vincent J.

    An evaluation of the U.S. Navy NOGAPS surface wind product is made to establish its utility as an initial descriptor of the surface wind field in the tropical Atlantic during SEQUAL. In this preliminary study, NOGAPS synoptic fields are compared to synoptic ship reports, and to winds measured at three separate stations along the equator during SEQUAL I. At least within 20° of the equator the comparisons suggest that the mean monthly surface winds from NOGAPS almost always differ by less than 2 m/s from averages of surface wind observations, and can be less than 1 m/s. Similar comparisons are also found from daily mean winds derived from NOGAPS, along the equator near 30°W. A comparison of NOGAPS monthly mean winds with 100-year climatology of merchant ship reports suggests that the major surface wind anomaly during SEQUAL I in the tropical Atlantic occurred in March and April 1983 along the equator west of 30°W.

  8. Cassini Observations of Saturn's Magnetotail Region: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Sittler, E. C.; Arridge, C.; Rymer, A.; Coates, A.; Krupp, N.; Blanc, M.; Richardson, J.; Andre, N.; Thomsen, M.; Tokar, R. L.; hide

    2007-01-01

    Using Cassini thermal plasma, hot plasma and magnetic field observations for several intervals between the dawn meridian of Saturn's outer magnetosphere and Saturn's magnetotail region, we investigate the structure of the magnetotail, plasma and magnetic field properties within tail-like current sheet regions and ion flows within the magnetotail regions. We use Cassini Plasma Spectrometer (CAPS) Ion Mass Spectrometer (IMS), Electron Plasma Spectrometer (ELS) observations, MIMI LEMMS ion and electron observations and Cassini magnetometer data (MAG) to characterize the plasma environment. IMS observations are used to measure plasma flow velocities from which one can infer rotation versus convective flows. IMS composition measurements are used to trace the source of plasma from the inner magnetosphere (protons, H2+ and water group ions) versus an external solar wind source (protons and e +i+on s). A critical parameter for both models is the strength of the convection electric field with respect to the rotational electric field for the large scale magnetosphere. For example, are there significant return flows (i.e., negative radial velocities, VR < 0) and/or plasmoids (V(sub R) > 0) within the magnetotail region? Initial preliminary evidence of such out flows and return flows was presented by Sittler et al. This talk complements the more global analysis by McAndrews et al.

  9. Genesis Silicon Carbide Concentrator Target 60003 Preliminary Ellipsometry Mapping Results

    NASA Technical Reports Server (NTRS)

    Calaway, M. J.; Rodriquez, M. C.; Stansbery, E. K.

    2007-01-01

    The Genesis concentrator was custom designed to focus solar wind ions primarily for terrestrial isotopic analysis of O-17/O-16 and O-18/O-16 to +/-1%, N-15/N-14 to +/-1%, and secondarily to conduct elemental and isotopic analysis of Li, Be, and B. The circular 6.2 cm diameter concentrator target holder was comprised of four quadrants of highly pure semiconductor materials that included one amorphous diamond-like carbon, one C-13 diamond, and two silicon carbide (SiC). The amorphous diamond-like carbon quadrant was fractured upon impact at Utah Test and Training Range (UTTR), but the remaining three quadrants survived fully intact and all four quadrants hold an important collection of solar wind. The quadrants were removed from the target holder at NASA Johnso n Space Center Genesis Curation Laboratory in April 2005, and have been housed in stainless steel containers under continual nitrogen purge since time of disintegration. In preparation for allocation of a silicon carbide target for oxygen isotope analyses at UCLA, the two SiC targets were photographed for preliminary inspection of macro particle contamination from the hard non-nominal landing as well as characterized by spectroscopic ellipsometry to evaluate thin film contamination. This report is focused on Genesis SiC target sample number 60003.

  10. Preliminary results of large-actuator-count MEMS DM development

    NASA Astrophysics Data System (ADS)

    Helmbrecht, Michael A.; He, Min; Rhodes, Patrick; Kempf, Carl J.

    2010-02-01

    Compensating for atmospheric turbulence in meter-class telescopes and for free-space communications can require deformable mirrors (DM) with hundreds of actuators. Advances in high-contrast imaging techniques and increased telescope sizes require DMs mirrors with thousands of actuators [1]-[3]. In response to these needs, Iris AO has been developing a nearly 500-actuator DM and is conducting pathfinding research into 3000-actuator class DMs. This paper begins with an overview of the segmented DM design and describes improvements made to the DM over the prior year in the areas of speed, high-quality dielectric coatings, and snap-in prevention structures. The paper then describes the next-generation PTT489 DM design and fabrication process. Failure modes encountered during fabrication are presented as well as test methods to detect the failure modes. Preliminary yield data are presented for the fabrication process as well. The paper concludes with a view to the future showing pathfinding research into 3000-actuator DMs.

  11. Cassini Observations of Saturn's Magnetotail Region: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Sittler, E. C.; Arridge, C.; Rymer, A.; Coates, A.; Krupp, N.; Blanc, M.; Richardson, J.; Andre, N.; Thomsen, M.; Tokar, R. L.; McAndrews, H. J.; Henderson, Mike; Cooper, J. F.; Burger, M.; Simpson, D.; Khurana, K. K.; Russell, C.; Dougherty, M.; Young, D. T.

    2007-01-01

    Using Cassini thermal plasma, hot plasma and magnetic field observations for several intervals between the dawn meridian of Saturn's outer magnetosphere and Saturn's magnetotail region, we investigate the structure of the magnetotail, plasma and magnetic field properties within tail-like current sheet regions and ion flows within the magnetotail regions. We use Cassini Plasma Spectrometer (CAPS) Ion Mass Spectrometer (IMS), Electron Plasma Spectrometer (ELS) observations, MIMI LEMMS ion and electron observations and Cassini magnetometer data (MAG) to characterize the plasma environment. IMS observations are used to measure plasma flow velocities from which one can infer rotation versus convective flows. IMS composition measurements are used to trace the source of plasma from the inner magnetosphere (protons, H2+ and water group ions) versus an external solar wind source (protons and e +i+on s). A critical parameter for both models is the strength of the convection electric field with respect to the rotational electric field for the large scale magnetosphere. For example, are there significant return flows (i.e., negative radial velocities, VR < 0) and/or plasmoids (V(sub R) > 0) within the magnetotail region? Initial preliminary evidence of such out flows and return flows was presented by Sittler et al. This talk complements the more global analysis by McAndrews et al.

  12. Physical activity in solid organ transplant recipients: organizational aspects and preliminary results of the Italian project.

    PubMed

    Roi, G S; Stefoni, S; Mosconi, G; Brugin, E; Burra, P; Ermolao, A; Granito, M; Macini, P; Mastrosimone, S; Nacchia, F; Pegoraro, C; Rigotti, P; Sella, G; Sgarzi, S; Tamè, M R; Totti, V; Trerotola, M; Tripi, F; Nanni Costa, A

    2014-09-01

    Most of the difficulties when trying to realize the proposal to prescribe physical activity for transplantation patients come from patient attitudes and cultural beliefs that ignore the benefits of exercise, but there also are organizational aspects arising from the difficulties that these patients face in accessing supervised exercise facilities. To address these difficulties, the Italian study project "Transplant … and Now Sport" was developed based on a model of cooperation among transplantation specialists, sports physicians, and exercise specialists organized as a team combining their specific skills to effectively actuate the physical exercise programs. This preliminary report is based on 26 patients (16 male, 10 female; 47.8±10.0 years old; 21 kidney and 5 liver transplantations; time from transplantation 2.3±1.4 years) who performed prescribed and supervised exercises consisting of 3 sessions per week of aerobic and strengthening exercises for 1 year. Preliminary results show a significant decrease in body mass index (t=1.966; P<.05) and a significant increase in peak aerobic power (t=4.535; P<.01) and maximum workload (t=4.665; P<.01) on the incremental cycling test. Also maximum strength of knee extensors (t=2.933; P<.05) and elbow flexors (t=2.450; P<.05) and countermovement jump performance (t=2.303; P<.05) significantly increased. Creatinine and proteinuria tended to decrease, but the differences were not significant. In health-related quality of life assessed by the SF-36 questionnaire, the Bodily Pain, General Health, Vitality, Social Functioning, and Role Emotional scale scores showed a significant improvement (P<.05). Preliminary results of the study protocol "Transplant…and Now Sport" show the positive effects of the model based on cooperation among transplantation centers, sports medicine centers, and gyms in the administration of a supervised exercise prescription. These data should be considered a contribution to developing and promoting

  13. Orthotopic total artificial heart bridge to transplantation: preliminary results.

    PubMed

    Copeland, J G; Smith, R; Icenogle, T; Vasu, A; Rhenman, B; Williams, R; Cleavinger, M

    1989-01-01

    A detailed summary of seven patients who received eight total artificial heart implants, including one Phoenix heart, two Jarvik 7-100 ml hearts, and five Jarvik 7-70 ml hearts, and nine heart transplants, reveals that bleeding, hemolysis, and thromboembolic and infectious problems are not the limiting factors. Size of the patient and the requirement for adequate space to permit adequate systemic and pulmonary venous filling seem to be the major limitations. Patients with a reasonable expectation of receiving a transplantation within 3 weeks are the best candidates for a bridge to transplantation. After this adhesions were found to cause severe technical problems at reoperation.

  14. Medial patellofemoral ligament and medial patellotibial ligament reconstruction in children: preliminary results.

    PubMed

    Sadigursky, David; Garcia, Lucas Cortizo; Armede, Maurício; Oliveira, Lucas Rodrigues de; Carneiro, Rogério Jamil Fernandes; Colavolpe, Paulo Oliveira

    2017-01-01

    The aim of this study was to evaluate the reconstruction of the medial patellofemoral ligament associated with the medial patellotibial ligament in skeletally immature patients. This is a case series study in patients with patellar instability with open physis. In total, seven patients were evaluated: four males and three females were operated using the proposed technique. Patients with open physis who had more than two episodes of recurring patellar dislocation were included. No patients underwent additional procedures. The distance from the anterior tibial tuberosity to the trochlea grove (TT-TG) was measured in all patients. On physical examination, the inverted J-sign, the apprehension sign, and the knee range of motion parameters were used in the pre- and post-operative period. In addition, the Kujala and Lysholm scores were applied before and 12 months after surgery. The results were analyzed with the Wilcoxon test. The mean age of the patients was 11.28 in both genders. Comparing the data of the pre- and post-operative period, the inverted J-sign was present in six patients (85.7%) vs. absent in one (14.3%). The apprehension sign was absent in cases in the postoperative period; the range of motion was 117.85 ± 8.09 vs. 148.57 ± 3.77. The Kujala score was 42.57 ± 8.9 vs. 88.57 ± 5.09 and the Lysholm scores were classified as excellent or good in 28.6% and 71.4%, respectively. The combined reconstruction of the medial patellofemoral ligament combined with the medial patellotibial ligament in skeletally immature patients with predisposing factors, presents satisfactory results without episodes of recurrence or residual subluxation; according to these preliminary results, it should be considered as a treatment option.

  15. Intensity Modulated Radiation Therapy for Primary Soft Tissue Sarcoma of the Extremity: Preliminary Results

    SciTech Connect

    Alektiar, Kaled M. . E-mail: alektiak@mskcc.org; Hong, Linda; Brennan, Murray F.; Della-Biancia, Cesar; Singer, Samuel

    2007-06-01

    Purpose: To report preliminary results on using intensity modulated radiation therapy (IMRT) as an adjuvant treatment in primary soft tissue sarcoma (STS) of the extremity. Methods and Materials: Between February 2002 and March 2005, 31 adult patients with primary STS of the extremity were treated with surgery and adjuvant IMRT. Tumor size was >10 cm in 74% of patients and grade was high in 77%. Preoperative IMRT was given to 7 patients (50 Gy) and postoperative IMRT (median dose, 63 Gy) was given to 24 patients. Complete gross resection including periosteal stripping or bone resection was required in 10, and neurolysis or nerve resection in 20. The margins were positive or within 1 mm in 17. Complications from surgery and radiation therapy (RT) were assessed using the Common Terminology Criteria for Adverse Events grading system. Results: Median follow-up time was 23 months. Grade 1 RT dermatitis developed in 71% of patients, Grade 2 in 16%, and Grade 3 in 10%. Infectious wound complications developed in 13% and noninfectious complications in 10%. Two patients (6.4%) developed fractures. Grade 1 neuropathy developed in 28% of patients and Grade 2 in 5%. The rates of Grade 1 and 2 joint stiffness were each 19%. Grade 1 edema was observed in 19% of patients and Grade 2 in 13%. The 2-year local control, distant control, and overall survival were 95%, 65%, and 81%, respectively. Conclusion: Intensity modulated RT appears to provide excellent local control in a difficult group of high-risk patients. The morbidity profile is also favorable, but longer follow-up is needed to confirm the results from this study.

  16. In-Transit Telemedicine Speeds Ischemic Stroke Treatment: Preliminary Results.

    PubMed

    Belt, Gary H; Felberg, Robert A; Rubin, Jane; Halperin, John J

    2016-09-01

    Time to treatment is critically important in ischemic stroke. We compared the efficacy and cost of teleneurology evaluation during patient transport with that of mobile stroke transport units. Using cellular-connected telemedicine devices, we assessed 89 presumptive stroke patients in ambulances in transit. Paramedics assisted remote teleneurologists in obtaining a simplified history and examination, then coordinating care with the receiving emergency department. We prospectively assessed door-to-needle and last-known-well-to-needle times for all intravenous alteplase-treated stroke patients brought to our emergency departments by emergency medical services' transport, comparing those with and without in-transit telestroke. From January 2015 through March 2016, 111 stroke patients received intravenous alteplase at study emergency departments. Mean door to needle was 13 minutes less with in-transit telestroke (28 versus 41; P=0.02). Although limitations in cellular communication degraded transmission quality, this did not prevent the completion of satisfactory patient evaluations. Improvement in time to treat seems comparable with in-transit telestroke and mobile stroke transport units. The low cost/unit makes this approach scalable, potentially providing rapid management of more patients. © 2016 American Heart Association, Inc.

  17. An Integrated, Acceptance-Based Behavioral Approach for Depression With Social Anxiety: Preliminary Results.

    PubMed

    Dalrymple, Kristy L; Morgan, Theresa A; Lipschitz, Jessica M; Martinez, Jennifer H; Tepe, Elizabeth; Zimmerman, Mark

    2014-07-01

    Depression and social anxiety disorder (SAD) are highly comorbid, resulting in greater severity and functional impairment compared with each disorder alone. Although recently transdiagnostic treatments have been developed, no known treatments have addressed this comorbidity pattern specifically. Preliminary support exists for acceptance-based approaches for depression and SAD separately, and they may be more efficacious for comorbid depression and anxiety compared with traditional cognitive-behavioral approaches. The aim of the current study was to develop and pilot test an integrated acceptance-based behavioral treatment for depression and comorbid SAD. Participants included 38 patients seeking pharmacotherapy at an outpatient psychiatry practice, who received 16 individual sessions of the therapy. Results showed significant improvement in symptoms, functioning, and processes from pre- to post-treatment, as well as high satisfaction with the treatment. These results support the preliminary acceptability, feasibility, and effectiveness of this treatment in a typical outpatient psychiatry practice, and suggest that further research on this treatment in larger randomized trials is warranted. © The Author(s) 2014.

  18. An Integrated, Acceptance-Based Behavioral Approach for Depression With Social Anxiety: Preliminary Results

    PubMed Central

    Dalrymple, Kristy L.; Morgan, Theresa A.; Lipschitz, Jessica M.; Martinez, Jennifer H.; Tepe, Elizabeth; Zimmerman, Mark

    2016-01-01

    Depression and social anxiety disorder (SAD) are highly comorbid, resulting in greater severity and functional impairment compared with each disorder alone. Although recently transdiagnostic treatments have been developed, no known treatments have addressed this comorbidity pattern specifically. Preliminary support exists for acceptance-based approaches for depression and SAD separately, and they may be more efficacious for comorbid depression and anxiety compared with traditional cognitive-behavioral approaches. The aim of the current study was to develop and pilot test an integrated acceptance-based behavioral treatment for depression and comorbid SAD. Participants included 38 patients seeking pharmacotherapy at an outpatient psychiatry practice, who received 16 individual sessions of the therapy. Results showed significant improvement in symptoms, functioning, and processes from pre- to post-treatment, as well as high satisfaction with the treatment. These results support the preliminary acceptability, feasibility, and effectiveness of this treatment in a typical outpatient psychiatry practice, and suggest that further research on this treatment in larger randomized trials is warranted. PMID:24402463

  19. Composition and Distribution of Northern Hellas Massifs: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Phillips, M. S.; Viviano-Beck, C. E.

    2016-12-01

    Martian plagioclase-rich deposits have been detected from orbit in the visible, near infrared and infrared wavelengths, and in-situ at Gale crater; however, the exact nature and origin of these deposits are not fully understood. Interpreted lithologies include felsic granitoid deposits, anorthosites, and plag-phyric basalts. The Noachian Hilly/Massif units near the northern rim of Hellas are the most areally-extensive region containing plagioclase-rich deposits identified thus far. We use morphological, spectral and thermal data from the Context Camera, Compact Reconnaissance Imaging Spectrometer for Mars (CRISM), and Thermal Emission Imaging Spectrometer (THEMIS) to consider the distribution and composition of massif features and subsequent implications for their origin. The spatial density of the massif features decreases with radial distance from Hellas, suggesting these features may be related to the Hellas impact event. If the massif features are uplifted or excavated material, they could represent pre-Noachian primary crustal lithologies. The primary compositions associated with the massifs as seen in the CRISM data are plagioclase, orthopyroxene, and olivine. Preliminary analyses suggest a tentative trend in compositions, with plagioclase-rich massifs closer to the basin and more olivine- and orthopyroxene-rich massifs further from the basin. This compositional trend could reveal a pre-Hellas-impact stratigraphy in the local primary crust. Further mapping and characterization are required to constrain the composition and distribution of massifs and determine their origin. We intend to use THEMIS spectral data to corroborate CRISM spectral identifications and to further constrain the compositions of the massif features. Identification of anorthositic rocks excavated from depth would have significant implications for the petrology of a primary crust on Mars and could support a magma ocean hypothesis similar to that suggested for the moon.

  20. Preliminary Results on Sediment Sorting Under Intense Bedload Transport

    NASA Astrophysics Data System (ADS)

    Hernandez Moreira, R. R.; Vautin, D.; Mathews, S. L.; Kuprenas, R.; Viparelli, E.

    2014-12-01

    Previous experiments show that parallel-laminated deposits are emplaced under upper plane bed regime by the migration of small-amplitude, long-wavelength bedforms. The present research focuses on how sediment is sorted under upper plane bed and sheet flow transport regimes, and whether parallel-lamination is inhibited during sheet flow transport. The problem of studying the sorting of sediment under so intense transport conditions is plagued by the uncertainties related to flow resistances and bedload transport rates. We simplify the problem by first running the experiments with uniform sediment, to establish a baseline that will aid in the design of the experiments with poorly sorted material. We are running experiments at the Hydraulics Laboratory of the Department of Civil and Environmental Engineering at the University of South Carolina in Columbia, in a unidirectional sediment-feed flume, 9 meters long by 0.2 meters wide, of which 7 meters are used as test section. During the experiments, water surface and bed elevations are periodically measured to characterize the global parameters of the flow, e.g. mean flow velocity and bed shear stress. When the flow and the sediment transport reach conditions of mobile bed equilibrium, bed elevation fluctuations are measured with ultrasonic transducer systems at six fixed locations. Channel bed aggradation is then induced by slowly raising the tail gate of the flume such that there is no change in transport regime, as confirmed by additional measurements of water surface and bed elevation and bed elevation fluctuations. Preliminary observations under upper plane bed regime show the formation of the small-amplitude and long-wavelength bedforms, as well as hints of parallel lamination in the deposits. In the near future we aim to achieve sheet flow transport conditions with both uniform and non-uniform grain size distributions to look at the internal structure of the emplaced deposit.

  1. Assessing Seasonal Lake Dynamics in Arctic Alaska: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Hinkel, K. M.; Beck, R. A.; Healey, N.; Jones, S.; Lenters, J.; Lyons, E. A.; Shah, C. A.; Sheng, Y.; Smith, L. C.; Winston, B. S.; Jones, B. M.

    2008-12-01

    Lakes on the coastal plain of arctic Alaska have developed atop continuous permafrost. Recent research suggests that lake levels, rates of bank erosion and drainage, and depth of the thaw bulb in sediments beneath the lake may increase in response to a warmer and wetter climate. Assessment of lake dynamics entails separating seasonal and interannual fluctuations from the long-term response. A program to study lake dynamics was initiated in 2008 and includes: (1) analysis of both long-term lake changes and seasonal/ interannual fluctuations using high-resolution satellite imagery and aerial photographs, (2) repeated high- resolution mapping of shoreline configuration in spring and late summer using differential GPS combined with water level sensors, (3) conducting bathymetric surveys to determine basin shape and water volume, (4) evaluating the relation between wind vectors and surface water currents with real-time satellite networked GPS-enabled floats and a wide-area wireless network, and (5) quantifying the energy and water balance on a representative lake using data collected from a fully instrumented buoy. Lake basins surveyed near Barrow, Alaska have a maximum depth of 1.5-3.0 m and are characterized by a steep drop-off near the shore and very gradual deepening toward the center. Seasonal shoreline fluctuations are observed in most lakes, with the maximum effect noted in low-lying regions of the lake margin as the water level gradually falls through summer. Preliminary analysis of the lake energy and water balance is presented, including measurements of incoming and outgoing radiation, latent and sensible heat flux, and associated lake temperature and atmospheric parameters. In subsequent years, measurements will be made on lakes further inland where the surficial geology and climate differs from the coastal environment.

  2. [The benefit of the da Vinci robotic system in abdominal oncosurgery - our preliminary results].

    PubMed

    Langer, D; Pudil, J; Rudiš, J; Ryska, M

    2013-02-01

    The robotization of minimally invasive treatment in surgery has been evident since the beginning of the third Millennium. The authors present their current evaluation of the benefits of the da Vinci robotic system in the treatment of abdominal malignancy. The authors summarize published studies in the Medline and Pubmed databases that compare robotic, laparoscopic and open approaches in the treatment of abdominal malignancy. Epidemiological data, intraoperative blood loss, complications and oncological outcomes are monitored in a group of 30 patients with carcinoma of rectum. The results measured in the evaluated parameters (open conversion, perioperative and non - surgery complications, intraoperative blood loss, histological findings, lethality) are similar in the published studies, i.e. without significant differences in both groups subject to the robotic and laparoscopic treatment. The operative time in the group of robotic surgery has been is slightly longer (a non-significant difference) in most of published studies. 30 patients underwent the robotic assisted treatment of the carcinoma of the rectum (14 men and 16 women, average age of 60 years (33-80). Neoadjuvant treatment was indicated in 50% of the patients. Average blood loss was 260 ml, transfusion was administered in one case. Conversion to laparotomic treatment was performed twice, four patients had post-operative complications, no patient has died. We have not found any relapse of oncological disease in the observed set to this date. The Da Vinci robotic system is a safe manipulator in the treatment of abdominal malignancy (including HPB surgery). Randomized clinical trials (RCT) have confirmed (short-term clinical and oncological) results comparable to the laparoscopic or open approach treatment. The benefits of robotic surgery for patients in abdominal surgery (long-term results, sufficient number of patients and high-grade EBM) are yet to be evaluated, however. It is necessary to implement more

  3. Transforming Growth Factor β-1 (TGF-β1) Is a Serum Biomarker of Radiation Induced Fibrosis in Patients Treated With Intracavitary Accelerated Partial Breast Irradiation: Preliminary Results of a Prospective Study

    SciTech Connect

    Boothe, Dustin L.; Coplowitz, Shana; Greenwood, Eleni; Barney, Christian L.; Christos, Paul J.; Parashar, Bhupesh; Nori, Dattatreyudu; Chao, K. S. Clifford; Wernicke, A. Gabriella

    2013-12-01

    Purpose: To examine a relationship between serum transforming growth factor β -1 (TGF-β1) values and radiation-induced fibrosis (RIF). Methods and Materials: We conducted a prospective analysis of the development of RIF in 39 women with American Joint Committee on Cancer stage 0-I breast cancer treated with lumpectomy and accelerated partial breast irradiation via intracavitary brachytherapy (IBAPBI). An enzyme-linked immunoassay (Quantikine, R and D, Minneapolis, MN) was used to measure serum TGF-β1 before surgery, before IBAPBI, and during IBAPBI. Blood samples for TGF-β1 were also collected from 15 healthy, nontreated women (controls). The previously validated tissue compliance meter (TCM) was used to objectively assess RIF. Results: The median time to follow-up for 39 patients was 44 months (range, 5-59 months). RIF was graded by the TCM scale as 0, 1, 2, and 3 in 5 of 20 patients (25%), 6 of 20 patients (30%), 5 of 20 patients (25%), and 4 of 20 patients (20%), respectively. The mean serum TGF-β1 values were significantly higher in patients before surgery than in disease-free controls, as follows: all cancer patients (30,201 ± 5889 pg/mL, P=.02); patients with any type of RIF (32,273 ± 5016 pg/mL, P<.0001); and women with moderate to severe RIF (34,462 ± 4713 pg/mL, P<0.0001). Patients with moderate to severe RIF had significantly elevated TGF-β1 levels when compared with those with none to mild RIF before surgery (P=.0014) during IBAPBI (P≤0001), and the elevation persisted at 6 months (P≤.001), 12 months (P≤.001), 18 months (P≤.001), and 24 months (P=.12). A receiver operating characteristic (ROC) curve of TGF-β1 values predicting moderate to severe RIF was generated with an area under the curve (AUC){sub ROC} of 0.867 (95% confidence interval 0.700-1.000). The TGF-β1 threshold cutoff was determined to be 31,000 pg/mL, with associated sensitivity and specificity of 77.8% and 90.0%, respectively. Conclusions: TGF-β1 levels correlate with

  4. Microbial extremophiles from the 2008 Schirmacher Oasis Expedition: preliminary results

    NASA Astrophysics Data System (ADS)

    Hoover, Richard B.; Pikuta, Elena V.; Townsend, Alisa; Anthony, Joshua; Guisler, Melissa; McDaniel, Jasmine; Bej, Asim; Storrie-Lombardi, Michael

    2008-08-01

    Among the most interesting targets for Astrobiology research are the polar ice caps and the permafrost of Mars and the ice and liquid water bodies that may lie beneath the frozen crusts of comets, the icy moons of Jupiter (Europa, Io and Ganymede) and Saturn (Titan and Enceladus). The permanently ice-covered lakes of Antarctica, such as Lake Vostok and Lake Untersee, provide some of the best terrestrial analogues for these targets. The 2008 International Tawani Schirmacher Oasis/Lake Untersee Expeditions have been organized to conduct studies of novel microbial extremophiles and investigate the biodiversity of the glaciers and ice-covered lakes of Dronning Maud Land, East Antarctica. This paper describes the preliminary analysis of the anaerobic microbial extremophiles isolated from samples collected during the 2008 International Schirmacher Oasis Antarctica Reconnaissance Expedition. These samples showed great diversity of psychrophlic and psychrotolerant bacteria. Six new anaerobic strains have been isolated in pure cultures and partially characterized. Two of them (strains ARHSd-7G and ARHSd-9G) were isolated from a small tidal pool near the colony of African Penguins Spheniscus demersus. Strain ARHSd-7G was isolated on mineral anaerobic medium with 3 % NaCl, pH 7 and D-glucose, it has motile, vibrion shape cells, and is Gram variable. Strain ARHSd-9G grew on anaerobic, alkaline medium with pH 9 and 1 % NaCl at 3°C. The substrate was D-glucose supplemented with yeast extract (0.05 %). Cells of strain ARHSd-9G had morphology of straight or slightly curved elongated rods and demonstrated unusual optical effects under dark-field visible light microscopy. The cells were spore-forming and Gram positive. From the mat sample collected near Lake Zub, the new strain LZ-3 was isolated in pure culture at 3°C. Strain LZ-3 was anaerobic and grew on 0.5 % NaCl mineral medium with Dglucose as a substrate. The gram positive cells were spore-forming. They exhibited a

  5. Preliminary results of the ground geophysical monitoring in Gschliefgraben

    NASA Astrophysics Data System (ADS)

    Jochum, Birgit; Lovisolo, Mario; Supper, Robert; Ita, Anna; Baron, Ivo; Ottowitz, David

    2010-05-01

    In September 2009, a fully automatic multiparametric in place column D.M.S. IUT, (68 sensors, active monitoring depth = 33 m) designed and manufactured by the Italian company C.S.G. S.r.l., was installed in an inclinometric borehole by helicopter at Gschliefgraben landslide. The landslide is affecting houses and a road at the eastern rim of the Traunsee and caused considerable damage in 2007/2008. The survey area is located at the border of the Flysch Zone and the Northern Limestone Alps, which is known to be prone to landslide activity. Extensive drainaging reduces the amount of precipitation seeping into the ground. Thus, the displacement monitored in real time by DMS at the present time seems to be not strickly dependent of rainfall. The preliminary data show a main sliding zone occurring at 10-12 m bgl. The mean velocity was 10 mm/month in the interval time 24 September - 24 November, then the time history shows an increase up to 15 mm/month until the end of December. In the first days of January 2010 the velocity trend is reducing to 2 mm/week. An extensive geolectrical survey has been performed before to interpret the subsurface structure regarding possible depths and spatial delimitation of the sliding zone and to find the best position of the monitoring system. In the vicinity of the inclinometer a geoelectric monitoring system (GeoMonitor4D, developed by the Geological Survey of Austria) was installed to correlate measured resistivity values with displacement rates. It consists of 2 profiles, with a length of 120m and 192m. Both systems send their data once a day automatically by UMTS to the data centers in Ricaldone (Italy) and Vienna (Austria). In spring 2010 a second DMS column will be placed at the foot of the hill. The integrated analysis of the airborne and ground measurements, carried out by the Geological Survey of Austria combined with several other parameters, provided by the Torrent and Avalanche Control, will contribute to understand the

  6. Magnetotelluric investigation across the Agri Valley: preliminary results.

    NASA Astrophysics Data System (ADS)

    Balasco, Marianna; Romano, Gerardo; Siniscalchi, Agata; Alfredo Stabile, Tony

    2017-04-01

    The Agri Valley is an axial zone of the Southern Apennines thrust belt chain with a strong seismogenic potential where two important energy technologies responsible for inducing/triggering seismicity are active: (1) the disposal at the Costa Molina 2 injection well of the wastewater produced during the exploitation of the biggest onshore oil field in west Europe (27 wells producing more than 80,000 barrels of crude oil per day), managed by the Eni S.p.A., and (2) the water loading and unloading operations in the Pertusillo artificial reservoir. It is recognized the possibility that the fluctuation of the water level inside the reservoir, due to the hydrological cycle for example, produces pressure perturbations at the bottom of reservoir, causing induced seismicity. Furthermore it is even more known the role of fluids in the rupture processes which could cause an increase of pore pressure specially at high rate of injection fluids and/or for the presence of weakening of preexisting faults. With the aim to better characterize and understand the physical processes involved in the observed induced/triggered seismicity, in 2016 a broadband seismic network, covering an area of about 20 km x 20 km nearby the Pertusillo Dam and Costa Molina2 well has been installed in the framework of SIR-MIUR project INSIEME (INduced Seismicity in Italy: Estimation, Monitoring, and sEismic risk mitigation) and a MagnetoTelluric (MT) survey has been performed. The MT investigation consists of 25 soundings aligned along 30 km profile oriented at about N40 direction, orthogonal with the strike of the major and noticeable geological structures and crossing both of the source that may induce/trigger seismicity. In this work, we present the preliminary 2D resistivity model which provides useful deep geophysical information for understanding the geological and structural setting of the Agri Valley. Moreover, the comparison of the resistivity model with the earthquake location as inferred from

  7. Comparison of stroke infarction between CT perfusion and diffusion weighted imaging: preliminary results

    NASA Astrophysics Data System (ADS)

    Abd. Rahni, Ashrani Aizzuddin; Arka, Israna Hossain; Chellappan, Kalaivani; Mukari, Shahizon Azura; Law, Zhe Kang; Sahathevan, Ramesh

    2016-03-01

    In this paper we present preliminary results of comparison of automatic segmentations of the infarct core, between that obtained from CT perfusion (based on time to peak parameter) and diffusion weighted imaging (DWI). For each patient, the two imaging volumes were automatically co-registered to a common frame of reference based on an acquired CT angiography image. The accuracy of image registration is measured by the overlap of the segmented brain from both images (CT perfusion and DWI), measured within their common field of view. Due to the limitations of the study, DWI was acquired as a follow up scan up to a week after initial CT based imaging. However, we found significant overlap of the segmented brain (Jaccard indices of approximately 0.8) and the percentage of infarcted brain tissue from the two modalities were still fairly highly correlated (correlation coefficient of approximately 0.9). The results are promising with more data needed in future for clinical inference.

  8. Exercise and severe depression: preliminary results of an add-on study.

    PubMed

    Schuch, F B; Vasconcelos-Moreno, M P; Borowsky, C; Fleck, M P

    2011-10-01

    Physical exercise has been extensively researched as a therapeutic option for treatment of major depression. In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5 kcal/kg/week, three times a week during all the hospitalization. Our preliminary results show that there is no significant difference in scores of Hamilton in the second week between groups (Mean[SD]=8.2[5.96] × 11.18[5.03], p=0.192). However, there is a significant reduction in Hamilton scores of patients in exercise group at discharge (Mean[SD]=5.93[4.46] × 9.45[3.56], p=0.041). Regarding Quality of Life (QoL), no significant difference were found between groups in the second week in physical domain (Mean[SD]=56.98[8.96] × 54.54[9.18], p=0.511) and psychological domain (Mean[SD]=50.88[13.88] × 42.04[12.42], p=0.106). However, there is a significant difference in psychological domain (Mean[SD]=55.88[9.92] v 41.66[13.04], p=0.004) and a trend but no statistical significance in the physical (Mean[SD]=58.80[9.14] × 52.12[8.70], p=0.07) at discharge. Many patients receive different treatment strategies, like ECT (1 patient at exercise group × 3 at control group). Other limitation is the small number of participants included until this moment. Our preliminary results suggest that physical exercise could be a feasible and effective add-on strategy for treatment of severe depressed inpatients, improving their depressive symptoms and QoL. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. The Sunphotometer Airborne Validation Experiment 2012: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Estellés, Victor; Marenco, Franco; Ryder, Claire L.; Campanelli, Monica; Expósito, Francisco; Solá, Yolanda; Segura, Sara; Marcos, Carlos; Toledano, Carlos; Berjón, Alberto; Guirado, Carmen; Claxton, Bernard; Todd, Martin

    2013-04-01

    to provide detailed vertically resolved aerosol measurements, in order to compare these to sunphotometer retrievals. Simultaneously, 4 different ground AERONET - Cimel sites were deployed in the Tenerife island, at different latitudes and altitudes for further investigation of spatial and vertical variability. Three of these sites also measured solar radiation components with CM21 pyranometers and CHP1 pirheliometers, for further research on radiative forcing of aerosols. One site was equipped with a Prede POM sun-sky radiometer for comparison with Cimel sunphotometer. On the other hand, for the FENNEC campaign another AERONET Cimel sunphotometer was deployed in Zouerate (Mauritania). The ideal conditions for such a comparison consisted of cloudless skies and high mineral aerosol burdens, brought by the Saharan outflow. Although these conditions were not reached in the Tenerife area during the scheduled field campaign, appropriate conditions were met in western Mauritania, over the AERONET Zouerate site. In this study, we perform a preliminary analysis of the columnar properties of aerosols in the Canary Islands and West Sahara areas during the FENNEC 2011 and FENNEC-SAVEX 2012 field campaigns, with an emphasis on the comparison between the size distributions retrieved from both AERONET and SKYRAD algorithms using the Zouerate Cimel site data. Validation of the vertical integrated aerosol size distributions will be also presented. References - M.Campanelli, V.Estelles, T. Smyth, T. Nakajima, M. Hashimoto, A.Lupi, C. Tomas, "Retrieval of aerosol radiative properties from sun-sky radiometers measurements of ESR network: comparison between the inversion codes Skyrad4.2.pack and the new Skyrad5.pack", European Aerosol Conference, 2011. - V. Estellés, M. Campanelli, M. P. Utrillas, F. Expósito, and J. A. Martínez-Lozano, "Comparison of AERONET and SKYRAD4.2 inversion products retrieved from a Cimel CE318 sunphotometer", Atmos. Meas. Tech. 5, 569—579, 2012.

  10. The Mount Logan (Yukon) Ice Cores: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fisher, D. A.

    2004-05-01

    Bourgeois, Mike Demuth, David Fisher, Roy Koerner,Chris Zdanowicz, James Zheng. University of Ottawa: Ian Clarke,Raphaelle Cardyn. National Institute of Polar Research (Japan): Kumiko Goto-Azuma University of New Hampshire: Cam Wake, Kaplan Yalcin. University of Maine: Karl Kreutz, Paul Mayewski, Erich Osterberg. Arctic Institute of North America: Gerald Holdsworth. University of Washington: Eric J. Steig, Summer B. Rupper. University of Copenhagen: Dorthe Dahl-Jensen. David Fisher is the presenter but many contributed to what is a joint preliminary offering.

  11. Radioimmunodetection of non-Hodgkin`s lymphoma with radiolabelled LL2 monoclonal antibody. Preliminary results

    SciTech Connect

    Gasparini, M.; Buraggi, G.L.; Tondini, C.

    1994-05-01

    Radioimmunodetection (RAID) with 99m technetium labelled B cell lymphoma monoclonal antibody (MAb) (IMMU-LL2 Fab`, Immunomedics, Inc., Morris Plains, N.J.) was investigated in 8 patients (5 female and 3 male; age range 20-72 years) with histologically proven non-Hodgkin`s lymphoma (NHL). Of the 8 lymphomas, 5 were intermediate grade and 3 low grade. Whole body images with multiple planar views were obtained at 30 min, 4-6 and 24 hours after the I.V. injection of 1 mg LL2-Fab` labelled with 20-25 mCi (740-925 MBq) {sup 99}Tc. SPECT of chest or abdomen was performed at 5-8 hours after injection in all patients. No adverse reactions were observed in any patient after MAb infusion and no appreciable changes were seen in the blood counts, renal and liver function tests. A total of 17 of 18 (94.4%) lymphoma lesions were detected by RAID. All the tumor localizations were confirmed by clinical examination and with other imaging techniques, such as CT scan, MRI or gallium scan. In this series of patients no false positive results were noted and only 1 false negative resulted in a patient who had a mediastinal bulky disease. As regard the biodistribution of the immunoreagent we can make the following conclusions: (1) no appreciable bone marrow activity was seen, (2) splenic targeting was demonstrated in all patients, (3) tumor-to-non tumor ratios ranged from 1.2 to 2.8 as measured by ROI technique, (4) no difference of uptake was noted for different tumor grades. The images performed 24 hours after injection did not detect new lesions, but areas of doubtful uptake were seen as positive focal areas in the delayed scan. In these preliminary results the LL2-Fab` MAb seems to be useful for detection, staging and follow up of NHL patients.

  12. Reconstruction of the abdominal wall by using a combination of the human acellular dermal matrix implant and an interpositional omentum flap after extensive tumor resection in patients with abdominal wall neoplasm: A preliminary result

    PubMed Central

    Gu, Yan; Tang, Rui; Gong, Ding-Quan; Qian, Yun-Liang

    2008-01-01

    AIM: To present our trial using a combination of the human acellular dermal matrix (HADM) implant and an interpositional omentum flap to repair giant abdominal wall defects after extensive tumor resection. METHODS: Between February and October of 2007, three patients with giant defects of the abdominal wall after extensive tumor resection underwent reconstruction with a combination of HADM and omentum flap. Postoperative morbidities and signs of herniation were monitored. RESULTS: The abdominal wall reconstruction was successful in these three patients, there was no severe morbidity and no signs of herniation in the follow-up period. CONCLUSION: The combination of HADM and omentum flap offers a new, safe and effective alternative to traditional forms in the repair of giant abdominal wall defects. Further analysis of the long-term outcome and more cases are needed to assess the reliability of this technique. PMID:18205267

  13. Safety of a 3-weekly schedule of carboplatin plus pegylated liposomal doxorubicin as first line chemotherapy in patients with ovarian cancer: preliminary results of the MITO-2 randomized trial

    PubMed Central

    Pignata, Sandro; Scambia, Giovanni; Savarese, Antonella; Breda, Enrico; Scollo, Paolo; De Vivo, Rocco; Rossi, Emanuela; Gebbia, Vittorio; Natale, Donato; Del Gaizo, Filomena; Naglieri, Emanuele; Ferro, Antonella; Musso, Pietro; D'Arco, Alfonso Maria; Sorio, Roberto; Pisano, Carmela; Di Maio, Massimo; Signoriello, Giuseppe; Annunziata, Annalisa; Perrone, Francesco

    2006-01-01

    Background The MITO-2 (Multicentre Italian Trials in Ovarian cancer) study is a randomized phase III trial comparing carboplatin plus paclitaxel to carboplatin plus pegylated liposomal doxorubicin in first-line chemotherapy of patients with ovarian cancer. Due to the paucity of published phase I data on the 3-weekly experimental schedule used, an early safety analysis was planned. Methods Patients with ovarian cancer (stage Ic-IV), aged < 75 years, ECOG performance status ≤ 2, were randomized to carboplatin AUC 5 plus paclitaxel 175 mg/m2, every 3 weeks or to carboplatin AUC 5 plus pegylated liposomal doxorubicin 30 mg/m2, every 3 weeks. Treatment was planned for 6 cycles. Toxicity was coded according to the NCI-CTC version 2.0. Results The pre-planned safety analysis was performed in July 2004. Data from the first 50 patients treated with carboplatin plus pegylated liposomal doxorubicin were evaluated. Median age was 60 years (range 34–75). Forty-three patients (86%) completed 6 cycles. Two thirds of the patients had at least one cycle delayed due to toxicity, but 63% of the cycles were administered on time. In most cases the reason for chemotherapy delay was neutropenia or other hematological toxicity. No delay due to palmar-plantar erythrodysesthesia (PPE) was recorded. No toxic death was recorded. Reported hematological toxicities were: grade (G) 3 anemia 16%, G3/G4 neutropenia 36% and 10% respectively, G3/4 thrombocytopenia 22% and 4% respectively. Non-haematological toxicity was infrequent: pulmonary G1 6%, heart rhythm G1 4%, liver toxicity G1 6%, G2 4% and G3 2%. Complete hair loss was reported in 6% of patients, and G1 neuropathy in 2%. PPE was recorded in 14% of the cases (G1 10%, G2 2%, G3 2%). Conclusion This safety analysis shows that the adopted schedule of carboplatin plus pegylated liposomal doxorubicin given every 3 weeks is feasible as first line treatment in ovarian cancer patients, although 37% of the cycles were delayed due to

  14. True and false autobiographical memories in schizophrenia: preliminary results of a diary study.

    PubMed

    Pernot-Marino, Elodie; Schuster, Caroline; Hedelin, Guy; Berna, Fabrice; Zimmermann, Marie-Agathe; Danion, Jean-Marie

    2010-08-30

    The frequency of true and false autobiographical memories and associated states of conscious awareness, i.e., conscious recollection and simply knowing, as well as the respective roles of affective and cognitive processes in autobiographical memory construction, were assessed in eight patients with schizophrenia and eight control participants. A diary study methodology was used in combination with the Remember/Know procedure. The results showed a higher frequency of Know responses associated with the retrieval of both true and false memories in patients than in control participants. Whereas control participants rated higher at retrieval than at encoding the distinctiveness and personal importance of events, as well as the extent to which events furthered current personal plans, patients exhibited an opposite pattern of ratings, with ratings being lower at retrieval than at encoding. These preliminary results show a high frequency of simply knowing associated with the retrieval of true and false autobiographical memories in patients with schizophrenia and provide evidence for the interest of the diary study methodology for studying autobiographical memory in schizophrenia.

  15. Photodynamic therapy with green light for the treatment of vulvar lichen sclerosus - Preliminary results.

    PubMed

    Osiecka, B J; Jurczyszyn, K; Nockowski, P; Murawski, M; Ziółkowski, P

    2017-03-01

    The standard treatment for lichen sclerosus (LS) is symptomatic and is primarily based on the chronic use of corticosteroids, sometimes resulting in unsatisfactory effects. Therefore, other non-pharmacological methods are being sought, which are less aggravating for the patient. LS can be treated topically by using photodynamic therapy (PDT) based on 5-aminolevulinic acid (5-ALA). Unfortunately, therapy with the red light is often connected with severe local pain during the illumination. Green light can also be characterised by its ability to turn on photodynamic reactions in cells. The aim of this study was an evaluation into the efficacy and tolerance of 5-ALA-PDT with a green light (540nm±15nm) in 11 patients with chronic LS that were characterised by severe itching. The disease lasted from 1.5 to 4 years. All the patients were treated with three sessions of PDT. Following treatment with PDT, a significant improvement of local status, as well as a reduction of the main symptom (pruritus), were observed. No patient complained of severe pain during the sessions that would have required an interruption of irradiation or local application of analgesics. Our preliminary results of using green light in PDT for superficial skin non-oncological lesions are very promising but require further studies. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Palliation of Postoperative Gastrointestinal Anastomotic Malignant Strictures with Flexible Covered Metallic Stents: Preliminary Results

    SciTech Connect

    Lee, Jeong-Min; Han, Young Min; Lee, Sang Yong; Kim, Chong Soo; Yang, Doo Hyun; Lee, Seung Ok

    2001-01-15

    Purpose: To evaluate the efficacy of the placement of covered metallic stents for palliation of gastrointestinal anastomotic strictures secondary to recurrent gastric cancer.Methods: Under fluoroscopic guidance, placement of one or two self-expandable covered metallic stents was attempted perorally in 11 patents (aged 48-76 years) with anastomotic stenoses due to recurrent gastric malignancies. The strictures involved both the afferent and efferent loops in three patients. All patients had poor peroral food intake with severe nausea and vomiting after ingestion. The technical and clinical success was evaluated.Results: Placement of the covered stent was technically successful in 13 of 15 (87%) attempts in ten patients. After the procedure, 9 of 11 (82%) patients overall were able to ingest at least a liquid diet and had markedly decreased incidence of vomiting. During the follow-up of 2-31 weeks (mean 8.5 weeks) there were no major complications.Conclusion: These preliminary results suggest that flexible, covered stents may provide effective palliation of malignant anastomotic stricture secondary to recurrent gastric cancer.

  17. [Development and preliminary results of a chromatic illumination system for indirect ophthalmoscopes].

    PubMed

    Oliveira, Thiago Bellini; Trevelin, Luis Carlos; Moreira, Fernando Manoel Araújo; Bagnato, Vanderlei Salvador; Schor, Paulo; Carvalho, Luis Alberto Vieira de

    2009-01-01

    Chromatic contrast is a technique used in some areas of medicine to provide better visualization of biological tissues. Based on principles of color composition, a new illumination system was constructed using colored emitting diodes to reproduce the spectral range of visible light. This technique was devised to be used in indirect ophthalmoscopes to improve the visualization of the posterior segment of the eye. The original illumination system of a general purpose indirect ophthalmoscope was substituted by a system of color-emitting diodes. Using an electronic interface it was possible to control the intensity of the color lights and therefore generate different wavelengths in the visible spectrum of the light. Preliminary tests undertaken in a mechanical model of the human eye generated very clear and homogenous colors. However in vivo examinations with patients were performed in our laboratory at the IFSC-USP and UNIFESP, and obtained the preliminary results show the possibilities of the chromatic contrast technique, and may represent in the future a differential in the analyses of the posterior segment of the eye. The use of color-emitting diodes to reproduce the spectral range of the visible light in indirect ophthalmoscopes seems to be a promising technological advance in the fundoscopy of the eye. This is an innovation that can yield better quality examinations with indirect ophthalmoscopes.

  18. Results of a preliminary assessment of an explosive projectile launch system

    SciTech Connect

    Reaugh, J.E.

    1995-07-31

    This report presents results on a preliminary assessment of accelerating a projectile by a sequence of timed explosions. Computerized simulations were performed with CALE, a two-dimensional Arbitrary Language Eulerian program to examine principles and preferred operating parameters.

  19. 76 FR 65497 - Freshwater Crawfish Tail Meat From the People's Republic of China: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE International Trade Administration Freshwater Crawfish Tail Meat From the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review and Intent To Rescind Review in Part...

  20. PRELIMINARY RESULTS: EVALUATIONS OF THE ALTERNATIVE ASBESTOS CONTROL METHOD FOR BUILDING DEMOLITION

    EPA Science Inventory

    This presentation describes the preliminary results of the evaluations of the alternative asbestos control method for demolishing buildings containing asbestos, and are covered under the regulatory requirements of the Asbestos NESHAP. This abstract and presentation are based, at ...

  1. 75 FR 26922 - Magnesium Metal From the Russian Federation: Preliminary Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... International Trade Administration Magnesium Metal From the Russian Federation: Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration..., Office 5, Import Administration, International Trade Administration, U.S. Department of Commerce,...

  2. 76 FR 47558 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... International Monetary Fund's publication International Financial Statistics (IMF Statistics). Ester received... International Trade Administration Polyethylene Terephthalate Film, Sheet, and Strip From India: Preliminary Results of Countervailing Duty Administrative Review AGENCY: Import Administration, International Trade...

  3. PRELIMINARY RESULTS: EVALUATIONS OF THE ALTERNATIVE ASBESTOS CONTROL METHOD FOR BUILDING DEMOLITION

    EPA Science Inventory

    This presentation describes the preliminary results of the evaluations of the alternative asbestos control method for demolishing buildings containing asbestos, and are covered under the regulatory requirements of the Asbestos NESHAP. This abstract and presentation are based, at ...

  4. In Situ Oxidation of Liquid Trichloroethylene by Permanganate Solutions: Preliminary Results of Column Studies

    SciTech Connect

    Schroth, Martin H.; Oostrom, Mart; Wietsma, Thomas W.; Istok, Jonathan D.; H.J. Morel-Seytoux

    2000-01-11

    In situ oxidation of liquid trichloroethylene by permanganate solutions: Preliminary results of column studies. In: Proceedings of the 19th American Geophysical Union Hydrology Days, H. J. Morel-Seytoux, ed., pp. 411-420. Hydrology Days Pub., Atherton, Ca.

  5. 77 FR 60103 - Fresh Tomatoes From Mexico: Notice of Preliminary Results of Changed Circumstances Review and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... percent of U.S. production of the domestic like product. Certain Orange Juice from Brazil: Preliminary..., 60242 (October 10, 2008), unchanged in Certain Orange Juice From Brazil: Final Results of Antidumping...

  6. Percutaneous Implantation of a Catheter with Subcutaneous Reservoir for Intraarterial Regional Chemotherapy: Technique and Preliminary Results

    SciTech Connect

    Grosso, Maurizio; Zanon, Claudio; Mancini, Andrea; Garruso, Matteo; Gazzera, Carlo; Anselmetti, Giovanni Carlo; Veglia, Simona; Gandini, Giovanni

    2000-03-15

    Purpose: We present the technique and the preliminary results of percutaneous implantation of intraarterial catheters connected to a subcutaneous infusion reservoir for prolonged regional chemotherapy of hepatic and extrahepatic tumors.Methods: Two hundred patients with primary or secondary hepatic neoplasms, pelvic, pancreatic, renal, lingual, and breast cancer underwent the procedure. The access was the left axillary artery (188 patients) and the femoral artery (12 patients). The catheter tip was placed in the hepatic (170 patients), hypogastric (18), splenic (4), internal thoracic (2), gastroduodenal (3), renal (2) or the external carotid artery (1). The catheter was connected to a subcutaneous reservoir and filled with heparin; chemotherapeutic infusion was subsequently started.Results: One hundred percent immediate technical success was obtained. Forty-three of 200 (21.5%) patients had a complication: 29 patients had a catheter dislodgment, nine had arterial thrombosis, three had a pseudoaneurysm of the left axillary artery and two had a port pocket hematoma. Most complications (37/43, 86%) were treated percutaneously without interruption of chemotherapy. In only six cases (3% of the total population) was chemotherapy discontinued due to the complication itself. The mean duration of catheter patency was 7.2 months.Conclusion: Percutaneous placement of an intraarterial catheter is feasible and causes less discomfort to the patient than the surgical approach. The technique has an acceptable complication rate (21.5%), similar to that for surgical implantation (17.8%), with the advantage that in most cases the complications can be resolved percutaneously. This technique represents an alternative to surgical implantation in the treatment of liver metastases from colorectal cancer and opens new therapeutic possibilities for the local prolonged treatment of other kinds of tumor, though its clinical efficacy must be assessed in selected trials.

  7. Extracellular remodeling in patients with wild-type amyloidosis consuming epigallocatechin-3-gallate: preliminary results of T1 mapping by cardiac magnetic resonance imaging in a small single center study.

    PubMed

    aus dem Siepen, Fabian; Buss, Sebastian J; Andre, Florian; Seitz, Sebastian; Giannitsis, Evangelos; Steen, Henning; Katus, Hugo A; Kristen, Arnt V

    2015-08-01

    T1 mapping by cardiac magnetic resonance imaging (CMR) is able to determine the extracellular volume fraction. Wild-type transthyretin amyloidosis (WT-ATTR) is characterized by extracellular amyloid deposition in the heart. Recent reports indicated a reduction of left ventricular (LV) myocardial mass in WT-ATTR after consumption of epigallocatechin-3-gallate, the main catechin in green tea. It remained unclear, whether reduction of LV myocardial mass reflects decrease of amyloid load or progressive atrophy of cardiomyocytes. This study included 7 male patients with CMR repetitively performed before and 12 months after daily consumption of green tea extract (600 mg epigallocatechin-3-gallate). Short axis slices as well as 2-, 3-, and 4-chamber views were acquired using SSFP sequences. T1 mapping was created out of 11 mid-ventricular short axis views with increasing inversion times using a single breath-hold modified look-locker inversion recovery sequence before and 15 min after Gadolinium contrast administration. After 12 months, a significant decrease of LV myocardial mass [198 (160; 212) vs. 180 (142; 204) g; p < 0.05] was observed. Moreover, a significant decrease of native [T1 1110 (1072; 1150) ms vs. 1080 (970; 1101), p < 0.05 or p = 0.03] was noticed. The calculated extracellular volume decreased in 5 patients (62.5%) by 7% and increased in 2 patients (37.5%) by 9.5%, in trend resulting in a (not significant) decrease of median ECV by 2.4%. Left ventricular ejection fraction (LVEF) [57 (48; 65) vs. 55 (47; 64) %; p = 0.3] remained unchanged. This study provided further evidence of LV myocardial mass reduction in patients with WT-ATTR daily consuming green tea extract. Additionally, this study gave first insights into the histomorphological correlate of LV mass reduction using T1 mapping. LV mass reduction appeared to be rather due to a decrease of amyloid load than atrophy of cardiomyocytes.

  8. Transsphenoidal pituitary resection with intraoperative MR guidance: preliminary results

    NASA Astrophysics Data System (ADS)

    Pergolizzi, Richard S., Jr.; Schwartz, Richard B.; Hsu, Liangge; Wong, Terence Z.; Black, Peter M.; Martin, Claudia; Jolesz, Ferenc A.

    1999-05-01

    The use of intraoperative MR image guidance has the potential to improve the precision, extent and safety of transsphenoidal pituitary resections. At Brigham and Women's Hospital, an open-bore configuration 0.5T MR system (SIGNA SP, GE Medical Systems, Milwaukee, WI) has been used to provide image guidance for nine transsphenoidal pituitary adenoma resections. The intraoperative MR system allowed the radiologist to direct the surgeon toward the sella turcica successfully while avoiding the cavernous sinus, optic chiasm and other sensitive structures. Imaging performed during the surgery monitored the extent of resection and allowed for removal of tumor beyond the surgeon's view in five cases. Dynamic MR imaging was used to distinguish residual tumor from normal gland and postoperative changes permitting more precise tumor localization. A heme-sensitive long TE gradient echo sequence was used to evaluate for the presence of hemorrhagic debris. All patients tolerated the procedure well without significant complications.

  9. Frequency-dependent complex modulus of the uterus: preliminary results

    NASA Astrophysics Data System (ADS)

    Kiss, Miklos Z.; Hobson, Maritza A.; Varghese, Tomy; Harter, Josephine; Kliewer, Mark A.; Hartenbach, Ellen M.; Zagzebski, James A.

    2006-08-01

    The frequency-dependent complex moduli of human uterine tissue have been characterized. Quantification of the modulus is required for developing uterine ultrasound elastography as a viable imaging modality for diagnosing and monitoring causes for abnormal uterine bleeding and enlargement, as well assessing the integrity of uterine and cervical tissue. The complex modulus was measured in samples from hysterectomies of 24 patients ranging in age from 31 to 79 years. Measurements were done under small compressions of either 1 or 2%, at low pre-compression values (either 1 or 2%), and over a frequency range of 0.1-100 Hz. Modulus values of cervical tissue monotonically increased from approximately 30-90 kPa over the frequency range. Normal uterine tissue possessed modulus values over the same range, while leiomyomas, or uterine fibroids, exhibited values ranging from approximately 60-220 kPa.

  10. Preliminary Results from the Application of Automated Adjoint Code Generation to CFL3D

    NASA Technical Reports Server (NTRS)

    Carle, Alan; Fagan, Mike; Green, Lawrence L.

    1998-01-01

    This report describes preliminary results obtained using an automated adjoint code generator for Fortran to augment a widely-used computational fluid dynamics flow solver to compute derivatives. These preliminary results with this augmented code suggest that, even in its infancy, the automated adjoint code generator can accurately and efficiently deliver derivatives for use in transonic Euler-based aerodynamic shape optimization problems with hundreds to thousands of independent design variables.

  11. Coastal Transport Integrated System in the Aegean Sea Islands: Framework, Methodology, Data Issues and Preliminary Results

    NASA Astrophysics Data System (ADS)

    Pantazis, D. N.; Stratakis, P.; Karathanasis, C.; Gkadolou, E.; Pagounis, V.; Chronis, K.; Gatsiou, M.; Moumouri-Frag, F.; Tsekos, P.

    2013-05-01

    Greece has more than one hundred inhabited islands, the majority of them are geographically scattered in small distances in the Aegean Sea. The Aegean Sea suffers systematically from two major issues. First, many islands are not served quite frequently with the continent or other islands' major ports. It is a situation rather problematic for the habitants of the islands who wish to travel, for the patients in need to be transferred to metropolitan hospitals, for the goods transport from and to islands. Second, there is a crucial issue in the Aegean Sea regarding the so-called "thin lines". Governments spend every year tens of million euros in subsidies in order to sustain the thin lines. Our aim is the development of an integrated and holistic spatial information system to effectively design coastal transportation lines to combat the above mentioned problems. This paper will present the project framework, the methodology followed, data issues and preliminary results.

  12. Preliminary results of laser ablation of the prostate versus TURP: a randomized study

    NASA Astrophysics Data System (ADS)

    Shaffer, Brian S.; Costello, Anthony J.

    1993-05-01

    Preliminary results of a randomized study comparing laser ablation of the prostate (LAP) to transurethral resection of the prostate (TURP) for the treatment of symptomatic benign prostatic hyperplasia are reviewed. Forty-five men enrolled in the study had a minimum 6 week followup. Preoperative AUA symptom scores, peak urinary flow rates, and post-void residual urines (PVR) were compared to postoperative values. The TURP group (22 men) did better than its LAP cohort (23 men) with a mean decrease in symptom score of 70% versus 47%, a mean increase in flow rate of 83% versus 53%, and a mean decrease in PVR of 51% versus 28%, respectively, at 12 weeks. LAP patients had less complications associated with impotence and retrograde ejaculation, required urethral catheters for less time, and had shorter hospital stays. With the development of more durable and reflective fibers the difference in efficacy between TURP and LAP should diminish while the benefits of LAP are preserved.

  13. Results of Ponseti Brasil Program: Multicentric Study in 1621 Feet: Preliminary Results.

    PubMed

    Nogueira, Monica P; Queiroz, Ana C D B F; Melanda, Alessandro G; Tedesco, Ana P; Brandão, Antonio L G; Beling, Claudio; Violante, Francisco H; Brandão, Gilberto F; Ferreira, Laura F A; Brambila, Leandro S; Leite, Leopoldina M; Zabeu, Jose L; Kim, Jung H; Fernandes, Kalyana E; Arima, Marcia A S; Aguilar, Maria D P Q; Farias Filho, Orlando C D; Oliveira Filho, Oscar B D A; Pinho, Solange D S; Moulin, Paulo; Volpi, Reinaldo; Fox, Mark; Greenwald, Miles F; Lyle, Brandon; Morcuende, Jose A

    The Ponseti method has been shown to be the most effective treatment for congenital clubfoot. The current challenge is to establish sustainable national clubfoot treatment programs that utilize the Ponseti method and integrate it within a nation's governmental health system. The Brazilian Ponseti Program (Programa Ponseti Brasil) has increased awareness of the utility of the Ponseti method and has trained >500 Brazilian orthopaedic surgeons in it. A group of 18 of those surgeons had been able to reproduce the Ponseti clubfoot treatment, and compiled their initial results through structured spreadsheet. The study compiled 1040 patients for a total of 1621 feet. The average follow-up time was 2.3 years with an average correction time of approximately 3 months. Patients required an average of 6.40 casts to achieve correction. This study demonstrates that good initial correction rates are reproducible after training; from 1040 patients only 1.4% required a posteromedial release. Level IV.

  14. A Preliminary Report on Some Recent Results in Born Inversion.

    DTIC Science & Technology

    2014-09-26

    of pseudo-differential operators, generalized Radon transforms, and generalized back projections. Moreover, Beylkin frames his work in an N...Beylkin uses powerful results in the theory of generalized Radon transforms. However, noting that the result on the left must involve a Dirac delta...pseudo-differential operators, generalized Radon transforms, and generalized back projections. Moreover, Beylkin frames his work in an N- dimensional

  15. Evaluating outcomes of palliative photodynamic therapy: instrument development and preliminary results

    NASA Astrophysics Data System (ADS)

    Goodell, Teresa T.; Bargo, Paulo R.; Jacques, Steven L.

    2002-06-01

    Background: Subjective measures are considered the gold standard in palliative care evaluation, but no studies have evaluated palliative photodynamic therapy (PDT) subjectively. If PDT is to be accepted as a palliative therapy for later-stage obstructing esophageal and lung cancer, evidence of its effectiveness and acceptability to patients must be made known. Study Design/Materials and Methods: This ongoing study's major aim is to evaluate subjective outcomes of PDT in patients with obstructing esophageal and lung cancer. Existing measures of health status, dysphagia and performance status were supplemented with an instrument developed to evaluate PDT symptom relief and side effect burden, the PDT Side Effects Survey (PSES). Results: PDT patients treated with porfimer sodium (Photofrin) and 630-nm light experienced reduced dysphagia grade and stable performance status for at least one month after PDT (N= 10-17), but these effects did not necessarily persist at three months. Fatigue, appetite and quality of life may be the most burdensome issues for these patients. Conclusions: Preliminary data suggest that the PSES is an acceptable and valid tool for measuring subjective outcomes of palliative PDT. This study is the first attempt to systematically evaluate subjective outcomes of palliative PDT. Multi-center outcomes research is needed to draw generalizable conclusions that will establish PDT's effectiveness in actual clinical practice and enhance the wider adoption of PDT as a cancer symptom relief modality.

  16. Value of bone scintiscan for diagnosis of arterial prosthesis infection: preliminary results.

    PubMed

    Lehalle, B; Lercher, M N; David, N; Olivier, P; Fiévé, G

    2000-09-01

    Diagnosis of arterial prosthetic infection is often difficult to confirm. Several cases of lower extremity hypertrophic osteoarthropathy (HOA) have been associated with arterial prosthetic infection. The presence of bone and joint abnormalities could constitute an early sign of HOA. The purpose of this prospective study was to determine the diagnostic value of routine bone scintiscan in patients hospitalized for suspected arterial prosthesis infection. Between December 1995 and May 1997, 17 patients with suspected infection were admitted to our institution. All underwent bone scintiscan before surgical treatment. Presence or absence of infection was defined according to the criteria proposed by Yeager. During the same period, bone scintiscan was performed in a control group of 8 patients with arterial prostheses but no clinical or laboratory signs of infection. Scintiscans were studied to detect bone and joint abnormalities distal to the arterial prosthesis. The results of this preliminary study indicate that routine bone scintiscan can assist definitive diagnosis in patients with suspected arterial prosthesis infection. Demonstration of bone and joint abnormalities distal to a prosthesis appears to be a fairly sensitive and highly specific sign of infection.

  17. Radiologically Defined Ecological Dynamics and Clinical Outcomes in Glioblastoma Multiforme: Preliminary Results1

    PubMed Central

    Zhou, Mu; Hall, Lawrence; Goldgof, Dmitry; Russo, Robin; Balagurunathan, Yoganand; Gillies, Robert; Gatenby, Robert

    2014-01-01

    MATERIALS AND METHODS: We examined pretreatment magnetic resonance imaging (MRI) examinations from 32 patients with glioblastoma multiforme (GBM) enrolled in The Cancer Genome Atlas (TCGA). Spatial variations in T1 post-gadolinium and either T2-weighted or fluid attenuated inversion recovery sequences from each tumor MRI study were used to characterize each small region of the tumor by its local contrast enhancement and edema/cellularity (“habitat”). The patient cohort was divided into group 1 (survival < 400 days, n = 16) and group 2 (survival > 400 days, n = 16). RESULTS: Histograms of relative values in each sequence demonstrated that the tumor regions were consistently divided into high and low blood contrast enhancement, each of which could be subdivided into regions of high, low, and intermediate cell density/interstitial edema. Group 1 tumors contained greater volumes of habitats with low contrast enhancement but intermediate and high cell density (not fully necrotic) than group 2. Both leave-one-out and 10-fold cross-validation schemes demonstrated that individual patients could be correctly assigned to the short or long survival group with 81.25% accuracy. CONCLUSION: We demonstrate that novel image analytic techniques can characterize regional habitat variations in GBMs using combinations of MRI sequences. A preliminary study of 32 patients from the TCGA database found that the distribution of MRI-defined habitats varied significantly among the different survival groups. Radiologically defined ecological tumor analysis may provide valuable prognostic and predictive biomarkers in GBM and other tumors. PMID:24772202

  18. Diabetic Macular Edema at the time of Cataract Surgery trial: a prospective, randomized clinical trial of intravitreous bevacizumab versus triamcinolone in patients with diabetic macular oedema at the time of cataract surgery - preliminary 6 month results.

    PubMed

    Lim, Lyndell L; Morrison, Julie L; Constantinou, Marios; Rogers, Sophie; Sandhu, Sukhpal S; Wickremasinghe, Sanjeewa S; Kawasaki, Ryo; Al-Qureshi, Salmaan

    2016-05-01

    To compare visual and anatomical outcomes between intravitreous bevacizumab (BVB, Avastin) and triamcinolone (TA, Triesence) when administered at the time of cataract surgery in patients with diabetic macular oedema (DME). Prospective, single-masked, randomized clinical trial at The Royal Victorian Eye and Ear Hospital, Melbourne. Patients with clinically significant cataract and either centre-involving DME or DME treated within the previous 24 months. Participants were randomized 1:1 to receive intravitreous BVB 1.25 mg or TA 4 mg during cataract surgery, and at subsequent review if required over 6 months. Change in central macular thickness (CMT) and best corrected visual acuity at 6 months. Forty-one patients (mean age 66.4 years, 73.2% male) were recruited. Visual acuity and CMT were similar between groups at baseline (P > 0.2).After six months, both groups gained vision (mean +21.4 letters in TA group P < 0.0001, +12.5 letters in BVB, P = 0.002), with no significant difference between groups (P = 0.085). In addition, 60.9% of eyes receiving TA achieved a VA of ≥6/12 compared to 73.3% in the BVB group (P = 0.501). However, only TA was associated with a sustained reduction in CMT (-43.8-µm reduction TA vs. +37.3-µm increase BVB, P = 0.006 over 6 months). Following surgery, additional injections were required in 70.6% of participants in the BVB group, compared to 16.7% in the TA group (P < 0.0001). Three patients in the TA group experienced a rise of IOP over 21 mmHg (12.5%) during the 6-month follow-up; BVB had no cases (P = 0.130). There were no cases of endophthalmitis in either group. When administered at the time of cataract surgery in patients with DME, at 6 months both TA and BVB improve visual acuity; however, only TA results in a sustained reduction in CMT. Further follow-up will determine whether this translates into better long-term visual outcomes in the TA group. © 2016 Royal Australian and New

  19. New preliminary results on the physics of charm hadroproduction subprocesses

    SciTech Connect

    Appel, J.A

    1994-10-01

    This paper reviews the results and physics of two contributed papers to ICHEP94. Both papers relate to charm meson hadroproduction at Fermilab fixed target energies. The first (from E769) addresses the total forward cross section for charm mesons (D{sup {plus_minus}} and D{sub s}{sup {plus_minus}}) produced by {pi}{sup {plus_minus}}, K{sup {plus_minus}}, and proton beams. The second paper (from E791) deals with the asymmetries in the differential cross sections for charged D mesons produced in the forward direction by {pi}{sup {minus}} beam. The physics most directly related to the results of the E769 paper are the gluon distributions in the incident hadrons as well as perturbative QCD calculations of charm quark production and the charm quark mass. The E791 results address the details of the hadronization process after production of the charm quarks.

  20. Correlation of thermography with spinal dysfunction: preliminary results

    PubMed Central

    Diakow, Peter RP; Ouellet, Sandra; Lee, Selina; Blackmore, Edward J

    1988-01-01

    The results of a blinded pilot study researching the correlation of thermographic abnormalities and spinal segmental dysfunction are presented. The highest agreement resulted between focal increases in thermal emission and fixation (64.7%). Other parameters studied were tenderness and textural skin changes which agreed with thermographic findings 63.7% and 59.9% respectively. Correlation coefficients were calculated for each subject and reasons for the wide range (r = .14 to .77) were discussed. Discussion of this research design and suggestions for future study were also presented.

  1. Bayesian Evidence for Two Populations of White Dwarfs: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Valentim, R.; Romero, A. D.; Kepler, S. O.; Horvath, J. E.; Rangel, E. M.

    2017-03-01

    White dwarf (WD) populations are analyzed using Bayesian tools, which allows inferring possible evolutionary paths through the study of the mass values. We employed a sample of 2761 DA white dwarf stars from the SDSS, and obtained the central mass values and their corresponding standard deviations using a bimodal population as an ansatz. The results indicate a population with M1 = 0.60 M⊙ and σ1 = 0.06 M⊙, corresponding to a single stellar evolution, and a second population with M2 = 1.00 M⊙ and σ1 = 0.11 M⊙ possibly due to binary evolution resulting from mergers.

  2. Novel benzophenothiazinium photosensitizers: preliminary in-vivo results

    NASA Astrophysics Data System (ADS)

    Cincotta, Anthony H.; Cincotta, Louis; Foley, James W.

    1990-07-01

    The photochemotherapeutic properties of several novel benzophenothiazines were evaluated zn-vzvo in three distinct tumor types consisting of a murine sarcoma, human carcinoma, and a rat glioma. Subcutaneous or intravenous administration of dyes to tumor bearing animals coupled with irradiation of the tumor area with 640 nm light resulted in substantial tumor necrosis 24h post photodynamic therapy as determined by histological evaluation. Significantly, there was minimal concurrent damage to the surrounding normal tissue. These results offer further evidence for the potential usefulness of benzophenothiazines in the photodynamic therapy of neoplasms.

  3. Preliminary Benchmarking and MCNP Simulation Results for Homeland Security

    SciTech Connect

    Robert Hayes

    2008-03-01

    The purpose of this article is to create Monte Carlo N-Particle (MCNP) input stacks for benchmarked measurements sufficient for future perturbation studies and analysis. The approach was to utilize historical experimental measurements to recreate the empirical spectral results in MCNP, both qualitatively and quantitatively. Results demonstrate that perturbation analysis of benchmarked MCNP spectra can be used to obtain a better understanding of field measurement results which may be of national interest. If one or more spectral radiation measurements are made in the field and deemed of national interest, the potential source distribution, naturally occurring radioactive material shielding, and interstitial materials can only be estimated in many circumstances. The effects from these factors on the resultant spectral radiation measurements can be very confusing. If benchmarks exist which are sufficiently similar to the suspected configuration, these benchmarks can then be compared to the suspect measurements. Having these benchmarks with validated MCNP input stacks can substantially improve the predictive capability of experts supporting these efforts.

  4. Articulatory measurement and synthesis. Methods and preliminary results.

    PubMed

    Heike, G

    1979-01-01

    The relations between area functions of the vocal tract and the acoustic result are of phonetic interest only if they can be interpreted in articulatory terms. We show which problems may arise if two-dimensional configurations of the vocal tract are to be transformed into area functions, and which relations exist between articulatory variables, area functions, and formant frequencies in an articulatory model.

  5. Family Characteristics of Anxious ADHD Children: Preliminary Results

    ERIC Educational Resources Information Center

    Kepley, Hayden O.; Ostrander, Rick

    2007-01-01

    Objective: To investigate the family environments of children in a community sample with ADHD and co-occurring anxiety. Method: Family Environment Scale, Behavioral Assessment System for Children, and Structured Clinical Interview are administered to parents of children with ADHD with and without anxiety. Results: ADHD families are uniformly less…

  6. Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

    PubMed Central

    Schulz, Antonia; Krabatsch, Thomas; Schmitto, Jan D.; Hetzer, Roland; Seidel, Mirko; Dohmen, Pascal M.; Hotz, Holger

    2016-01-01

    Background The C-Pulse® System is an extra-aortic balloon counterpulsation device. It is used to treat patients with heart failure disease in NYHA functional class III or ambulatory class IV. Material/Methods We present preliminary site-reported 6-month data from 3 centers in Germany as part of the prospective observational post-market OPTIONS HF study. Results Between May 2013 and March 2014, the C-Pulse System was implanted in 8 patients (7 male) with a mean age of 61.6±9.3 years. Four had ischemic and 4 had non-ischemic cardiomyopathy. No stroke, myocardial infarction, major bleeding, or major infection due to the device were reported. One patient developed non-device-related refractory tachycardia with worsening heart failure 12 h after surgery and underwent left ventricular assist device implantation. Within 6 months of observation, functional status improved from NYHA III to II in 5 patients, and 2 remained in NYHA III. Mean left ventricular ejection fraction increased from 24.3±7.9% to 44.5±4.5% (p<0.0001). Mean Kansas City Cardiomyopathy Questionnaire overall score improved from 28.6±19.1 to 59.1±22.5 (p=0.0183). Six-minute walk test was performed in 6 out of 7 patients at follow-up. The mean distance improved from 252.0±85.1 m to 279.2±87.5 m (p>0.05). One patient was weaned off the device after 6 months of support. Conclusions The C-Pulse System provides a therapeutic option for patients with moderate-to-severe heart failure and seems to improve quality of life and cardiac function over time. PMID:26887528

  7. Preliminary Results from the QuietSpike Flight Test

    NASA Technical Reports Server (NTRS)

    Haering, Edward A., Jr.; Cliatt, Larry J., II; Howe, Don; Waithe, Kenrick

    2007-01-01

    This viewgraph presentation reviews the QuietSpike flight test results. It shows the previous tests from Nearfield probes. The presentation then reviews the approach to test the QuietSpike, and shows graphics of the positions of the test vehicles. It also shows the components of the Sonic Boom Probing Noseboom. A graph of the Pressure Over- Under-shoot (Shaped Sonic Boom Demonstration (SSBD)Data) is presented. It reviews the Shock Probing Orientations, explaining that the probing plane is always behind the tail of the QuietSpike jet. Graphs of the Shock Position Geometry (SSBD Data) and the QuietSpike signature as of the test on 12/13/06, Near-Field Probing Directly Under the QuietSpike jet, and Near-Field Probing to Side, Near-Field Probing Above and to Side. Several slides review the Computational Fluid Dynamic models, and results compared to the probe tests.

  8. Preliminary results of in vitro propagation of Guayule

    NASA Technical Reports Server (NTRS)

    Dastoor, M. N.; Schubert, W. W.; Petersen, G. R.

    1981-01-01

    Guayule, Parthenium argentatum Gray, was first established in tissue culture by Bonner and Arreguin (1950) as a means to study the effects of various chemicals and extracts on rubber production. The propagation of whole guayule plants from tissue culture, however, has not been accomplished. The reported investigation is concerned with such an objective. In an attempt to stimulate rubber production in Guayule, Yokoyama et al. (1977) sprayed juvenile plants with 2-(3,4-dichloro-phenoxy)triethylamine (TEA derivative). This treatment resulted in increased isoprenoid levels in the plant tissue. In the current investigation, experiments were conducted to study the effect of TEA derivative on in vitro cultures. It was found that a suppression of callus formation occurs at a 10 mg/L concentration of TEA derivative with a resultant increase of shoot formation. Lower and higher concentrations of TEA derivative promote callus formation.

  9. Double Hale's cycle in changes of sunspot diameters. Preliminary results

    NASA Astrophysics Data System (ADS)

    Lozitsky, V.; Efimenko, V.

    2017-06-01

    Integral distributions for diameters of sunspots are analyzed in cycles Nos. 12-24. For determination of index of integral distribution α, the large sunspots of 50-90 Mm are taken into account; all data are averaged for each 11-year cycle for better accuracy. The main results are following: (a) the mean value of α index is 5.4 for last 13 cycles; (b) secular trend in changes of α index is absent, and (c) there are reliable evidences of double Hale's cycle (about 44 years). In particular, the lowest values of α index were found for cycles Nos. 14, 17-18 and 22. Since this index reflects the dispersion of sunspot diameters, obtained results indicate that convective zone of the Sun generates the embryos of active regions in different statistical regimes which change with cycle about 44 years.

  10. Finding four dimensional symplectic maps with reduced chaos: Preliminary results

    SciTech Connect

    Weishi Wan; Cary, J.R.; Shasharina, S.G.

    1998-06-01

    A method for finding integrable four-dimensional symplectic maps is outlined. The method relies on solving for parameter values at which the linear stability factors of the fixed points of the map have the values corresponding to integrability. This method is applied to accelerator lattices in order to increase dynamic aperture. Results show a increase of the dynamic aperture after correction, which implies the validity of the method.

  11. Preliminary results from the LDEF/UTIAS composite materials experiment

    NASA Technical Reports Server (NTRS)

    Tennyson, R. C.; Mabson, G. E.; Morison, W. D.; Kleiman, J.

    1992-01-01

    A total of 107 epoxy matrix composite samples containing carbon, boron, and aramid fiber reinforcements were flown on the Long Duration Exposure Facility (LDEF) satellite. For the first 371 days after deployment, strain and temperature data were recorded every 16 hours. Results were obtained on time to outgas, dimensional changes, coefficients of thermal expansion, atomic oxygen erosion, and damage due to micrometeoroid/debris impacts.

  12. Viking orbital colorimetric images of mars: Preliminary results

    USGS Publications Warehouse

    Soderblom, L.A.

    1976-01-01

    Color reconstruction and ratios of orbital images of Mars confirm Earth-based measurements showing red/violet ratios for bright areas to be roughly 1.5 times greater than dark areas. The new results show complex variation among dark materials; dark streaks emanating from craters in southern cratered terrains are much bluer than dark materials of the north equatorial plains on which Viking 1 landed.

  13. Preliminary Results form the Japanese Total Lightning Network

    NASA Astrophysics Data System (ADS)

    Hobara, Y.; Ishii, H.; Kumagai, Y.; Liu, C.; Heckman, S.; Price, C. G.; Williams, E. R.

    2015-12-01

    We report on the initial observational results from the first Japanese Total Lightning Detection Network (JTLN) in relation to severe weather phenomena. The University of Electro-Communications (UEC) has deployed the Earth Networks (EN) Total Lightning System over Japan to carry out research on the relationship between thunderstorm activity and severe weather phenomena since 2013. In this paper we first demonstrate the current status of our new network followed by the initial scientific results. The lightning jump algorithm was applied to our total lightning data to study the relationship between total lighting activity and hazardous weather events such as gust fronts and tornadoes over land reported by the JMA (Japanese Meteorological Agency) in 2014. As a result, a clear increase in total lighting flash rate as well as lightning jumps are observed prior to most hazardous weather events (~20 min) indicating potential usefulness for early warning in Japan. Furthermore we are going to demonstrate the relationship of total lightning activities with meteorological radar data focusing particularly on Japanese Tornadic storms.

  14. Magnetic field studies by Voyager 2 - Preliminary results at Saturn

    NASA Technical Reports Server (NTRS)

    Ness, N. F.; Acuna, M. H.; Behannon, K. W.; Burlaga, L. F.; Connerney, J. E. P.; Lepping, R. P.; Neubauer, F. M.

    1982-01-01

    Results of Voyager 2 studies of the magnetosphere and planetary magnetic field of Saturn are presented. Magnetometer studies have confirmed the results obtained by Voyager 1, indicating the magnetic field to be that of a centered dipole of moment 0.21 gauss Saturn radii-cubed, tilted approximately 0.8 deg from the rotation axis and a maximum measured field intensity of 1187 nT at latitude 17.3 deg N just before periapsis. Voyager 2 observed multiple bow shock and magnetopause crossings during its inbound and outbound trajectories, which were complementary to those of Voyager 1, including magnetopause crossing at 18.5 Saturn radii on the inbound trajectory, and at 48.4-50.9 Saturn radii outbound indicative of magnetospheric expansion due to changing solar wind conditions. Throughout the outbound passage, the magnetospheric field was observed to be relatively steady and smooth, with no evidence for any azimuthal asymmetry or magnetic anomaly. Results thus are incapable of accounting for the observed periodic modulation of the Saturnian kilometric radio emissions.

  15. Hawaii scientific drilling protect: Summary of preliminary results

    USGS Publications Warehouse

    DePaolo, D.; Stolper, E.; Thomas, D.; Albarede, F.; Chadwick, O.; Clague, D.; Feigenson, M.; Frey, F.; Garcia, M.; Hofmann, A.; Ingram, B.L.; Kennedy, B.M.; Kirschvink, J.; Kurz, M.; Laj, Carlo; Lockwood, J.; Ludwig, K.; McEvilly, T.; Moberly, R.; Moore, G.; Moore, J.; Morin, R.; Paillet, F.; Renne, P.; Rhodes, M.; Tatsumoto, M.; Taylor, H.; Walker, G.; Wilkins, R.

    1996-01-01

    Petrological, geochemical, geomagnetic, and volcanological characterization of the recovered core from a 1056-m-deep well into the flank of the Mauna Kea volcano in Hilo, Hawaii, and downhole logging and fluid sampling have provided a unique view of the evolution and internal structure of a major oceanic volcano unavailable from surface exposures. Core recovery was ???90%, yielding a time series of fresh, subaerial lavas extending back to ???400 ka. Results of this 1993 project provide a basis for a more ambitious project to core drill a well 4.5 km deep in a nearby location with the goal of recovering an extended, high-density stratigraphic sequence of lavas.

  16. Biotransformation of phosphogypsum on distillery decoctions (Preliminary results).

    PubMed

    Wolicka, Dorota; Kowalski, Włodzimierz

    2006-01-01

    The paper presents the activity of anaerobic bacterial communities isolated from soil polluted by aircraft fuel on distillery decoctions with phosphogypsum. The microorganisms were selected using the microcosms method, and then enriched on Postgate medium with ethanol. The isolated communities became the inoculum to establish a culture on potato and rye distillery decoctions. The obtained results show that a simultaneous removal of two industrial wastes such as phosphogypsum and distillery decoctions is possible. The introduction of a inoculation comprising a selected anaerobic bacterial community into the culture does not influence the increase of the biotransformation process efficiency.

  17. Development and preliminary results of radio frequency ion source

    SciTech Connect

    Xie, Yahong Hu, Chundong; Jiang, Caichao; Chen, Yuqian; Gu, Yumin; Su, Renxue; Xie, Yuanlai; Liu, Zhimin

    2016-02-15

    A radio frequency (RF) ion source was designed and developed for neutral beam injector. A RF driver test bed was used with a RF generator with maximum power of 25 kW with 1 MHz frequency and a matching box. In order to study the characteristic of RF plasma generation, the capacitance in the matching box was adjusted with different cases. The results show that lower capacitance will better the stability of the plasma with higher RF power. In the future, new RF coils and matching box will be developed for plasma generators with higher RF power of 50 kW.

  18. Laser comb with velocity bunching: Preliminary results at SPARC

    NASA Astrophysics Data System (ADS)

    Ferrario, M.; Alesini, D.; Bacci, A.; Bellaveglia, M.; Boni, R.; Boscolo, M.; Calvani, P.; Castellano, M.; Chiadroni, E.; Cianchi, A.; Cultrera, L.; di Pirro, G.; Ficcadenti, L.; Filippetto, D.; Gallo, A.; Gatti, G.; Giannessi, L.; Labat, M.; Lupi, S.; Marchetti, B.; Marrelli, C.; Migliorati, M.; Mostacci, A.; Nicoletti, D.; Pace, E.; Palumbo, L.; Petrillo, V.; Quattromini, M.; Ronsivalle, C.; Rossi, A. R.; Rosenzweig, J.; Serafini, L.; Serluca, M.; Spataro, B.; Tomizawa, H.; Vaccarezza, C.; Vicario, C.

    2011-05-01

    A new technique, named “laser comb”, was tested during the last SPARC run. It is able to produce electron pulse trains with a charge of some hundreds pC, a repetition rate of some terahertz, and a sub-picosecond length. This technique is based on the velocity bunching configuration of the SPARC injector. It can be useful to drive pump and probe free-electron laser experiments, to generate coherent excitation of plasma waves in plasma accelerators, and to produce narrow band terahertz radiation. In this paper, we describe the experimental results achieved so far and provide a comparison with simulations.

  19. Preliminary meteorological results on Mars from the viking 1 lander.

    PubMed

    Hess, S L; Henry, R M; Leovy, C B; Ryan, J A; Tillman, J E; Chamberlain, T E; Cole, H L; Dutton, R G; Greene, G C; Simon, W E; Mitchell, J L

    1976-08-27

    The results from the meteorology instruments on the Viking 1 lander are presented for the first 4 sols of operation. The instruments are working satisfactorily. Temperatures fluctuated from a low of 188 degrees K to an estimated maximum of 244 degrees K. The mean pressure is 7.65 millibars with a diurnal variation of amplitude 0.1 millibar. Wind speeds averaged over several minutes have ranged from essentially calm to 9 meters per second. Wind directions have exhibited a remarkable regularity which may be associated with nocturnal downslope winds and gravitational oscillations, or to tidal effects of the diurnal pressure wave, or to both.

  20. Preliminary results of the 249Cf + 48Ca experiment

    SciTech Connect

    Patin, J B; Moody, K J; Stoyer, M A; Wild, J F; Shaughnessy, D A; Stoyer, N J

    2003-11-03

    The results of a detailed analysis performed on the data obtained in the {sup 249}Cf + {sup 48}Ca bombardment is presented. This analysis is independent of the original data analysis performed in Dubna in which two possible decay chains were found. The first decay chain consisted of an evaporation residue implantation followed by two alpha decays and then a spontaneous fission. The second decay chain consisted of an evaporation residue implantation followed by an immediate spontaneous fission event. This analysis confirms that the two interesting events are present in the data. A summary of the two events will be given as well as a description of the analysis performed.

  1. Preliminary results of Finnish-Hungarian Doppler Observation Campaign.

    NASA Astrophysics Data System (ADS)

    Czobor, A.; Ádám, J.; Mihály, S.; Vass, T.; Parm, T.; Ollikainen, M.

    The Finnish-Hungarian Doppler Observation Campaign was carried out in Finland in August 1983 during 13 days. The campaign was organized by the Finnish Geodetic Institute. Three Hungarian JMR-1A receivers and one Finnish JMR-4 occupied 9 stations together with the 1st order triangulation network points of Finland. The data processing was performed in the Satellite Geodetic Observatory, Penc. The observation strategy, the methods of data processing and results obtained by GEODOP and SADOSA programs as well as the S-transformations are presented in this paper.

  2. Simulation of diurnal thermal energy storage systems: Preliminary results

    NASA Astrophysics Data System (ADS)

    Katipamula, S.; Somasundaram, S.; Williams, H. R.

    1994-12-01

    This report describes the results of a simulation of thermal energy storage (TES) integrated with a simple-cycle gas turbine cogeneration system. Integrating TES with cogeneration can serve the electrical and thermal loads independently while firing all fuel in the gas turbine. The detailed engineering and economic feasibility of diurnal TES systems integrated with cogeneration systems has been described in two previous PNL reports. The objective of this study was to lay the ground work for optimization of the TES system designs using a simulation tool called TRNSYS (TRaNsient SYstem Simulation). TRNSYS is a transient simulation program with a sequential-modular structure developed at the Solar Energy Laboratory, University of Wisconsin-Madison. The two TES systems selected for the base-case simulations were: (1) a one-tank storage model to represent the oil/rock TES system; and (2) a two-tank storage model to represent the molten nitrate salt TES system. Results of the study clearly indicate that an engineering optimization of the TES system using TRNSYS is possible. The one-tank stratified oil/rock storage model described here is a good starting point for parametric studies of a TES system. Further developments to the TRNSYS library of available models (economizer, evaporator, gas turbine, etc.) are recommended so that the phase-change processes is accurately treated.

  3. Effects of magnetic soil on metal detectors: preliminary experimental results

    NASA Astrophysics Data System (ADS)

    Das, Y.

    2007-04-01

    In a series of previous papers, analytical results dealing with the effects of soil electromagnetic properties on the performance of induction metal detectors were reported. In this paper experimental data are provided to verify some previously reported results. The time-domain response of a magnetic soil half-space and a small metallic sphere situated in air as well as buried in the soil were measured using a purpose-designed system based on a modified Schiebel AN19/2 metal detector. As in the previous work, the sphere is chosen as a simple prototype for the small metal parts in low-metal landmines. The soil used was Cambodian "laterite" with dispersive magnetic susceptibility, which serves as a good model for soils that are known to adversely affect the performance of metal detectors. The metal object used was a sphere of diameter 0.0254 m made of 6061-T6 aluminum. Experimental data are in good agreement with theoretical predictions. Data also show that for the weakly magnetic soil used in the experiments, the total response of the buried sphere is the sum of the response of the soil and that of the sphere placed in air. This finding should simplify the prediction or measurement of response of buried targets as one can separately measure/compute the response of an object in air and that of the host media and simply add the two. This simplification may not be possible for soils that are more strongly magnetic.

  4. Preliminary results of Mn partitioning experiments on Murchison analogues

    NASA Technical Reports Server (NTRS)

    Boesenberg, Joseph S.; Delaney, Jeremy S.

    1993-01-01

    Eucrites, howardites, and diogenites have Fe/Mn ratios between 30 and 45, while carbonaceous chondrites have much higher values between 90 and 150. Stolper (1977) first showed that basaltic achondrites could evolve from a precursor chondritic material through simple partial melting. These experiments indicated that chondritic material heated to temperatures near 1180 C with a fugacity of one log unit below the iron-wustite buffer curve, produced a eucritic mineralogy that contained olivine, pigeonite, plagioclase, spinel, glass, and metal. The partial melting experiments of Jurewicz et al. (1992) on an hydrous Murchison and Allende also showed that HED compositions were produceable at temperatures between 1130 C and 1325 C with fugacities below and above the iron-wustite buffer curve. However, the MnO abundances of Jurewicz were too low to produce suitable Fe/Mn ratios for HED's. We present below our results of partial melting experiments on Murchison analogues that involved temperatures between 1180 C and 1580 C and fugacities below the iron-wustite buffer curve. Our experiments resulted in MnO abundances nearly twice that of Jurewicz and indicate that the production of basaltic achondrite-like Fe/Mn ratios from precursor chondritic material are possible.

  5. Speckle imaging with the MAMA detector: Preliminary results

    NASA Technical Reports Server (NTRS)

    Horch, E.; Heanue, J. F.; Morgan, J. S.; Timothy, J. G.

    1994-01-01

    We report on the first successful speckle imaging studies using the Stanford University speckle interferometry system, an instrument that uses a multianode microchannel array (MAMA) detector as the imaging device. The method of producing high-resolution images is based on the analysis of so-called 'near-axis' bispectral subplanes and follows the work of Lohmann et al. (1983). In order to improve the signal-to-noise ratio in the bispectrum, the frame-oversampling technique of Nakajima et al. (1989) is also employed. We present speckle imaging results of binary stars and other objects from V magnitude 5.5 to 11, and the quality of these images is studied. While the Stanford system is capable of good speckle imaging results, it is limited by the overall quantum efficiency of the current MAMA detector (which is due to the response of the photocathode at visible wavelengths and other detector properties) and by channel saturation of the microchannel plate. Both affect the signal-to-noise ratio of the power spectrum and bispectrum.

  6. Preliminary Results From the UNICIT High Frequency Microwave Palaeointensity System

    NASA Astrophysics Data System (ADS)

    Biggin, A.; Boehnel, H.; Walton, D.

    2002-05-01

    Two of the biggest problems encountered when using the Thellier method to obtain estimates of the geomagnetic field intensity in the past are thermochemical alteration occurring during the experiments and the time intensive nature of the experiments themselves. Together these factors frequently yield a frustratingly low ratio of success achieved to time spent in the laboratory. However this ratio can be much increased, if microwave radiation instead of conventional thermal energy is used to excite the ferromagnetic grains within samples. Following the recent success of the geomagnetism group at the University of Liverpool in using microwave radiation to perform palaeointensity experiments, a new system has been developed at the Earth science research unit (UNICIT) of UNAM in Querétaro, Mexico. Conceptually, it differs from the Liverpool system (described in the literature) only in that it is designed to use higher frequency microwave radiation (12 to 18 GHz as opposed to 8.5 GHz) as a more efficient means to excite the ferromagnetic systems of materials. The system has been used to perform modified Thellier palaeointensity experiments on volcanic samples which had previously had a full TRM imparted to them using a known field in the laboratory. The results of these experiments were very encouraging and will be presented. Currently, samples derived from recent volcanic material which has previously undergone conventional Thellier analysis are being studied using the microwave system. Results from these experiments will also be discussed.

  7. (67)Ga and (68)Ga purification studies: preliminary results.

    PubMed

    Costa, R F; Barboza, M F; Osso, J A

    2013-01-01

    The positron emission tomography technique is very useful for diagnosis of several diseases. (68)Ga is a positron emitter with half-life of 67.7 min. As it is available from (68)Ge/(68)Ga generator systems, it is not necessary to have a nearby cyclotron. However, the eluate from commercial generators contains high levels of metallic impurities, which compete with (68)Ga in biomolecular labeling. Thus, a subsequent purification step is needed after generator elution. Here we present the results of two different methods developed for handmade purification of (68)Ga and (67)Ga for subsequent radiolabeling of biomolecules. Two purification methods were employed. The first one uses a cation exchange resin, and (68)Ga is eluted with a solution of acetone/acid. The second method of purification is performed by column chromatography solvent extraction, with (68)Ga recovery in deionized water. The best result was achieved with cationic resin AG50W-X8 (>400 mesh). However, the resin is not commercially available. The extraction chromatography column based on absorption of diisopropyl ether in XAD-16 is the most promising purification method. Although the levels of (68)Ga recovery and purification were smaller with the cationic resin method, its advantage is the (68)Ga recovery in deionized water.

  8. Preliminary time-phased TWRS process model results

    SciTech Connect

    Orme, R.M.

    1995-03-24

    This report documents the first phase of efforts to model the retrieval and processing of Hanford tank waste within the constraints of an assumed tank farm configuration. This time-phased approach simulates a first try at a retrieval sequence, the batching of waste through retrieval facilities, the batching of retrieved waste through enhanced sludge washing, the batching of liquids through pretreatment and low-level waste (LLW) vitrification, and the batching of pretreated solids through high-level waste (HLW) vitrification. The results reflect the outcome of an assumed retrieval sequence that has not been tailored with respect to accepted measures of performance. The batch data, composition variability, and final waste volume projects in this report should be regarded as tentative. Nevertheless, the results provide interesting insights into time-phased processing of the tank waste. Inspection of the composition variability, for example, suggests modifications to the retrieval sequence that will further improve the uniformity of feed to the vitrification facilities. This model will be a valuable tool for evaluating suggested retrieval sequences and establishing a time-phased processing baseline. An official recommendation on tank retrieval sequence will be made in September, 1995.

  9. Preliminary results of Mn partitioning experiments on Murchison analogues

    NASA Technical Reports Server (NTRS)

    Boesenberg, Joseph S.; Delaney, Jeremy S.

    1993-01-01

    Eucrites, howardites, and diogenites have Fe/Mn ratios between 30 and 45, while carbonaceous chondrites have much higher values between 90 and 150. Stolper (1977) first showed that basaltic achondrites could evolve from a precursor chondritic material through simple partial melting. These experiments indicated that chondritic material heated to temperatures near 1180 C with a fugacity of one log unit below the iron-wustite buffer curve, produced a eucritic mineralogy that contained olivine, pigeonite, plagioclase, spinel, glass, and metal. The partial melting experiments of Jurewicz et al. (1992) on an hydrous Murchison and Allende also showed that HED compositions were produceable at temperatures between 1130 C and 1325 C with fugacities below and above the iron-wustite buffer curve. However, the MnO abundances of Jurewicz were too low to produce suitable Fe/Mn ratios for HED's. We present below our results of partial melting experiments on Murchison analogues that involved temperatures between 1180 C and 1580 C and fugacities below the iron-wustite buffer curve. Our experiments resulted in MnO abundances nearly twice that of Jurewicz and indicate that the production of basaltic achondrite-like Fe/Mn ratios from precursor chondritic material are possible.

  10. Speckle imaging with the MAMA detector: Preliminary results

    NASA Technical Reports Server (NTRS)

    Horch, E.; Heanue, J. F.; Morgan, J. S.; Timothy, J. G.

    1994-01-01

    We report on the first successful speckle imaging studies using the Stanford University speckle interferometry system, an instrument that uses a multianode microchannel array (MAMA) detector as the imaging device. The method of producing high-resolution images is based on the analysis of so-called 'near-axis' bispectral subplanes and follows the work of Lohmann et al. (1983). In order to improve the signal-to-noise ratio in the bispectrum, the frame-oversampling technique of Nakajima et al. (1989) is also employed. We present speckle imaging results of binary stars and other objects from V magnitude 5.5 to 11, and the quality of these images is studied. While the Stanford system is capable of good speckle imaging results, it is limited by the overall quantum efficiency of the current MAMA detector (which is due to the response of the photocathode at visible wavelengths and other detector properties) and by channel saturation of the microchannel plate. Both affect the signal-to-noise ratio of the power spectrum and bispectrum.

  11. Preliminary Hydrogeologic Characterization Results from the Wallula Basalt Pilot Study

    SciTech Connect

    B.P. McGrail; E. C. Sullivan; F. A. Spane; D. H. Bacon; G. Hund; P. D. Thorne; C. J. Thompson; S. P. Reidel; F. S. Colwell

    2009-12-01

    The DOE's Big Sky Regional Carbon Sequestration Partnership has completed drilling the first continental flood basalt sequestration pilot borehole to a total depth (TD) of 4,110 feet on the Boise White Paper Mill property at Wallula, Washington. Site suitability was assessed prior to drilling by the 2007-2008 acquisition, processing and analysis of a four-mile, five-line three component seismic swath, which was processed as a single data-dense line. Analysis of the seismic survey data indicated a composite basalt formation thickness of {approx}8,000 feet and absence of major geologic structures (i.e., faults) along the line imaged by the seismic swath. Drilling of Wallula pilot borehole was initiated on January 13, 2009 and reached TD on April 6, 2009. Based on characterization results obtained during drilling, three basalt breccia zones were identified between the depth interval of 2,716 and 2,910 feet, as being suitable injection reservoir for a subsequent CO2 injection pilot study. The targeted injection reservoir lies stratigraphically below the massive Umtanum Member of the Grande Ronde Basalt, whose flow-interior section possesses regionally recognized low-permeability characteristics. The identified composite injection zone reservoir provides a unique and attractive opportunity to scientifically study the reservoir behavior of three inter-connected reservoir intervals below primary and secondary caprock confining zones. Drill cuttings, wireline geophysical logs, and 31one-inch diameter rotary sidewall cores provided geologic data for characterization of rock properties. XRF analyses of selected rock samples provided geochemical characterizations of the rocks and stratigraphic control for the basalt flows encountered by the Wallula pilot borehole. Based on the geochemical results, the pilot borehole was terminated in the Wapshilla Ridge 1 flow of the Grande Ronde Basalt Formation. Detailed hydrologic test characterizations of 12 basalt interflow reservoir

  12. Seismic Observations From the Afar Rift Dynamics Project: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Hammond, J. O.; Guidarelli, M.; Belachew, M.; Keir, D.; Ayele, A.; Ebinger, C.; Stuart, G.; Kendall, J.

    2008-12-01

    Following the 2005 Dabbahu rifting event in Afar, 9 broadband seismometers were installed around the active rift segment to study the microseismicity associated with this and subsequent dyking events. These recorded more than one year of continuous data. In March 2007, 41 stations were deployed throughout Afar and the adjacent rift flanks as part of a large multi-national, collaboration involving universities and organisations from the UK, US and Ethiopia. This abstract describes the crustal and upper mantle structure results of the first 19 months of data. Bulk crustal structure has been determined using the H-k stacking of receiver functions and thickness varies from ~45 km on the rift margins to ~16 km beneath the northeastern Afar stations. Estimates of Vp/Vs show normal continental crust values (1.7-1.8) on the rift margins, and very high values (2.0-2.2) in Afar. A study of seismic noise interferometry is in early stages, but inversions using 20 s Green's function estimates, with some control from regional surface waves, show evidence for thin crustal regions around the recently rifted Dabbahu segment. To improve our understanding of the physical and compositional properties of the crust and locate regions of high attenuation (an indicator of melt), we determine attenuation (Q) using t* values measured from spectra of P wave arrivals. We present whole path attenuation from source to receiver, which will provide a starting point for a future tomographic inversion. SKS-wave splitting results show sharp changes over small lateral distances (40° over <30 km), with fast directions overlying the Dabbahu segment aligning parallel with the recent diking. This supports ideas of melt dominated anisotropy beneath the Ethiopian rift. Seismic tomography inversions show that in the top 150 km low velocities mimic the trend of the seismicity in Afar. The low velocity anomalies extend from the main Ethiopian rift NE, towards Djibouti, and from Djibouti NW towards the

  13. Psychotherapy with borderline patients: II. A preliminary cost benefit study.

    PubMed

    Stevenson, J; Meares, R

    1999-08-01

    The aim of this study was to conduct a preliminary cost benefit study of the effect of outpatient psychotherapy, twice a week for 1 year, in 30 borderline patients. Costs to the health system in terms of inpatient care for the year before treatment were compared with the costs for the year following treatment. The cost of hospital admissions for the 30 patients for the year before treatment was $684 346 (range = $0-$143 756/patient). The cost of hospital admissions for the year after treatment was $41 424 (range = $0-$12 333/patient). These figures represent an average decrease in costs per patient of $21 431. By using the schedule fee as the basis, the estimated cost of therapy per patient was approximately $13 000, representing a saving/patient of $8431 or approximately $250 000 over the total cohort in the first year after treatment. This study suggests that there is a significant cost benefit in the appropriate treatment of borderline patients.

  14. Preliminary results from the heavy ions in space experiment

    NASA Technical Reports Server (NTRS)

    Adams, J. H., Jr.; Beahm, L. P.; Tylka, A. J.

    1991-01-01

    The Heavy Ions In Space (HIIS) experiment is intended to provide a deep survey of intensely ionizing particles in low earth orbit. Intensely ionizing particles produce single event effects in microelectronic components and are now recognized as the principal cause of spacecraft anomalies. These particles also make an important contribution to radiation doses. Besides the practical applications, HIIS data will be used to study several important scientific questions. By measuring heavy ions that stop in HIIS, the anomalous component of cosmic rays can be studied, evidence can be searched for of heavy ions trapped in the earth's magnetic field and by comparing HISS data with observations from outside the magnetosphere, the mean ionic charge state can be determined of solar energetic particles. HIIS will also record relativistic ultraheavy galactic cosmic rays. Their elemental composition will be measured from tin to uranium. Results are presented on the elemental resolution for stopping heavy ions and relativistic heavy ions.

  15. Preliminary Results of Cleaning Process for Lubricant Contamination

    SciTech Connect

    Eisenmann, D.; Brasche, L.; Lopez, R.

    2006-03-06

    Fluorescent penetrant inspection (FPI) is widely used for aviation and other components for surface-breaking crack detection. As with all inspection methods, adherence to the process parameters is critical to the successful detection of defects. Prior to FPI, components are cleaned using a variety of cleaning methods which are selected based on the alloy and the soil types which must be removed. It is also important that the cleaning process not adversely affect the FPI process. There are a variety of lubricants and surface coatings used in the aviation industry which must be removed prior to FPI. To assess the effectiveness of typical cleaning processes on removal of these contaminants, a study was initiated at an airline overhaul facility. Initial results of the cleaning study for lubricant contamination in nickel, titanium and aluminum alloys will be presented.

  16. Preliminary Results of Testing of Flow Effects on Evaporator Scaling

    SciTech Connect

    Hu, M.Z.

    2002-02-15

    This investigation has focused on the effects of fluid flow on solids deposition from solutions that simulate the feed to the 2H evaporator at the Savannah River Site. Literature studies indicate that the fluid flow (or shear) affects particle-particle and particle-surface interactions and thus the phenomena of particle aggregation in solution and particle deposition (i.e., scale formation) onto solid surfaces. Experimental tests were conducted with two configurations: (1) using a rheometer to provide controlled shear conditions and (2) using controlled flow of reactive solution through samples of stainless steel tubing. All tests were conducted at 80 C and at high silicon and aluminum concentrations, 0.133 M each, in solutions containing 4 M sodium hydroxide and 1 A4 each of sodium nitrate and sodium nitrite. Two findings from these experiments are important for consideration in developing approaches for reducing or eliminating evaporator scaling problems: (1) The rheometer tests suggested that for the conditions studied, maximum solids deposition occurs at a moderate shear rate, approximately 12 s{sup -1}. That value is expected to be on the order of shear rates that will occur in various parts of the evaporator system; for instance, a 6 gal/min single-phase liquid flow through the 2-in. lift or gravity drain lines would result in a shear rate of approximately 16 s{sup -1}. These results imply that engineering approaches aimed at reducing deposits through increased mixing would need to generate shear near all surfaces significantly greater than 12 s{sup -1}. However, further testing is needed to set a target value for shear that is applicable to evaporator operation. This is because the measured trend is not statistically significant at the 95% confidence interval due to variability in the results. In addition, testing at higher temperatures and lower concentrations of aluminum and silicon would more accurately represent conditions in the evaporator. Without

  17. Preliminary results from the ASF/GPS ice classification algorithm

    NASA Technical Reports Server (NTRS)

    Cunningham, G.; Kwok, R.; Holt, B.

    1992-01-01

    The European Space Agency Remote Sensing Satellite (ERS-1) satellite carried a C-band synthetic aperture radar (SAR) to study the earth's polar regions. The radar returns from sea ice can be used to infer properties of ice, including ice type. An algorithm has been developed for the Alaska SAR facility (ASF)/Geophysical Processor System (GPS) to infer ice type from the SAR observations over sea ice and open water. The algorithm utilizes look-up tables containing expected backscatter values from various ice types. An analysis has been made of two overlapping strips with 14 SAR images. The backscatter values of specific ice regions were sampled to study the backscatter characteristics of the ice in time and space. Results show both stability of the backscatter values in time and a good separation of multiyear and first-year ice signals, verifying the approach used in the classification algorithm.

  18. Preliminary Results of Cleaning Process for Lubricant Contamination

    NASA Astrophysics Data System (ADS)

    Eisenmann, D.; Brasche, L.; Lopez, R.

    2006-03-01

    Fluorescent penetrant inspection (FPI) is widely used for aviation and other components for surface-breaking crack detection. As with all inspection methods, adherence to the process parameters is critical to the successful detection of defects. Prior to FPI, components are cleaned using a variety of cleaning methods which are selected based on the alloy and the soil types which must be removed. It is also important that the cleaning process not adversely affect the FPI process. There are a variety of lubricants and surface coatings used in the aviation industry which must be removed prior to FPI. To assess the effectiveness of typical cleaning processes on removal of these contaminants, a study was initiated at an airline overhaul facility. Initial results of the cleaning study for lubricant contamination in nickel, titanium and aluminum alloys will be presented.

  19. Automated Optical Meteor Fluxes and Preliminary Results of Major Showers

    NASA Technical Reports Server (NTRS)

    Blaauw, R.; Campbell-Brown, M.; Cooke, W.; Kingery, A.; Weryk, R.; Gill, J.

    2014-01-01

    NASA's Meteoroid Environment Office (MEO) recently established a two-station system to calculate daily automated meteor fluxes in the millimeter-size-range for both single-station and double-station meteors. The cameras each consist of a 17 mm focal length Schneider lens (f/0.95) on a Watec 902H2 Ultimate CCD video camera, producing a 21.7x15.5 degree field of view. This configuration sees meteors down to a magnitude of +6. This paper outlines the concepts of the system, the hardware and software, and results of 3,000+ orbits from the first 18 months of operations. Video from the cameras are run through ASGARD (All Sky and Guided Automatic Real-time Detection), which performs the meteor detection/photometry, and invokes MILIG and MORB (Borovicka 1990) codes to determine the trajectory, speed, and orbit of the meteor. A subroutine in ASGARD allows for approximate shower identification in single-station detections. The ASGARD output is used in routines to calculate the flux. Before a flux can be calculated, a weather algorithm indicates if sky conditions are clear enough to calculate fluxes, at which point a limiting magnitude algorithm is employed. The limiting stellar magnitude is found using astrometry.net (Lang et al. 2012) to identify stars and translated to the corresponding shower and sporadic limiting meteor magnitude. It is found every 10 minutes and is able to react to quickly changing sky conditions. The extensive testing of these results on the Geminids and Eta Aquariids is shown. The flux involves dividing the number of meteors by the collecting area of the system, over the time interval for which that collecting area is valid. The flux algorithm employed here differs from others currently in use in that it does not make the gross oversimplication of choosing a single height to calculate the collection area of the system. In the MEO system, the volume is broken up into a set of height intervals, with the collecting areas determined by the position of the

  20. Preliminary Results from a superconducting photocathode sample cavity

    SciTech Connect

    Peter Kneisel; Jacek Sekutowicz; R. Lefferts; A. Lipski

    2005-05-01

    Pure niobium has been proposed as a photocathode material to extract directly photo-currents from the surface of a RF-gun cavity [1]. However, the quantum efficiency of niobium is {approx}3 {center_dot} 10{sup -4}, whereas electro- or vacuum deposited lead has an {approx} 10 times higher quantum efficiency. We have designed and tested a photo-injector niobium cavity, which can be used to insert photo-cathodes made of different materials in the high electric field region of the cavity. Experiments have been conducted with niobium and lead, which show that neither the Q- values of the cavity nor the obtainable surface fields are significantly lowered. This paper reports about the results from these tests.

  1. Preliminary results of indoor radon survey in V4 countries.

    PubMed

    Muűllerová, M; Kozak, K; Kovács, T; Csordás, A; Grzadziel, D; Holý, K; Mazur, J; Moravcsík, A; Neznal, M; Neznal, M; Smetanová, I

    2014-07-01

    The measurements of radon activity concentration carried out in residential houses of V4 countries (Hungary, Poland and Slovakia) show that radon levels in these countries considerably exceed the world average. Therefore, the new radon data and statistical analysis are required from these four countries. Each partner chose a region in their own country, where radon concentration in residential buildings was expected to be higher. The results of the survey carried out in the period from March 2012 to May 2012 show that radon concentrations are <200 Bq m(-3) in ∼87% of cases. However, dwellings with radon concentration ∼800 Bq m(-3) were found in Poland and Slovakia. It was also found that the distribution of radon frequency follows that of houses according to the year of their construction.

  2. Preliminary results of Linear Induction Accelerator LIA-200

    NASA Astrophysics Data System (ADS)

    Sharma, Archana; Senthil, K.; Praveen Kumar, D. D.; Mitra, S.; Sharma, V.; Patel, A.; Sharma, D. K.; Rehim, R.; Kolge, T. S.; Saroj, P. C.; Acharya, S.; Amitava, Roy; Rakhee, M.; Nagesh, K. V.; Chakravarthy, D. P.

    2010-05-01

    Repetitive Pulsed Power Technology is being developed keeping in mind the potential applications of this technology in material modifications, disinfections of water, timber, and food pasteurization etc. BARC has indigenously developed a Linear Induction Accelerator (LIA-200) rated for 200 kV, 4 kA, 100 ns, 10 Hz. The satisfactory performance of all the sub-systems including solid state power modulator, amorphous core based pulsed transformers, magnetic switches, water capacitors, water pulse- forming line, induction adder and field-emission diode have been demonstrated. This paper presents some design details and operational results of this pulsed power system. It also highlights the need for further research and development to build reliable and economic high-average power systems for industrial applications.

  3. Magnetic field studies at Jupiter by Voyager 1: Preliminary results

    NASA Technical Reports Server (NTRS)

    Ness, N. F.; Acuna, M. H.; Lepping, R. P.; Burlaga, L. F.; Behannon, K. W.; Neubauer, F. M.

    1979-01-01

    Results obtained by the Goddard Space Flight Center magnetometers on Voyager 1 concerning the large scale configuration of the Jovian bow shock and magnetopause, and the magnetic field in both the inner and outer magnetosphere are highlighted. There is evidence that a magnetic tail extending away from the planet on the nightside is formed by the solar wind-Jovian field interaction. This is much like Earth's magnetosphere but is a new configuration for Jupiter's magnetosphere not previously considered from earlier Pioneer data. Magnetic field perturbations associated with intense electrical currents (approximately 5 x 10 to the 6th power amps) flowing near or in the magnetic flux tube linking Jupiter with the satellite Io and induced by the relative motion between Io and the co-rotating Jovian magnetosphere are analyzed and interpreted. These currents may be an important source of heating the ionosphere and interior of Io through Joule dissipation.

  4. Preliminary results from the ASF/GPS ice classification algorithm

    NASA Technical Reports Server (NTRS)

    Cunningham, G.; Kwok, R.; Holt, B.

    1992-01-01

    The European Space Agency Remote Sensing Satellite (ERS-1) satellite carried a C-band synthetic aperture radar (SAR) to study the earth's polar regions. The radar returns from sea ice can be used to infer properties of ice, including ice type. An algorithm has been developed for the Alaska SAR facility (ASF)/Geophysical Processor System (GPS) to infer ice type from the SAR observations over sea ice and open water. The algorithm utilizes look-up tables containing expected backscatter values from various ice types. An analysis has been made of two overlapping strips with 14 SAR images. The backscatter values of specific ice regions were sampled to study the backscatter characteristics of the ice in time and space. Results show both stability of the backscatter values in time and a good separation of multiyear and first-year ice signals, verifying the approach used in the classification algorithm.

  5. Aeolian abrasion on Venus: Preliminary results from the Venus simulator

    NASA Technical Reports Server (NTRS)

    Marshall, J. R.; Greeley, Ronald; Tucker, D. W.; Pollack, J. B.

    1987-01-01

    The role of atmospheric pressure on aeolian abrasion was examined in the Venus Simulator with a constant temperature of 737 K. Both the rock target and the impactor were fine-grained basalt. The impactor was a 3 mm diameter angular particle chosen to represent a size of material that is entrainable by the dense Venusian atmosphere and potentially abrasive by virtue of its mass. It was projected at the target 10 to the 5 power times at a velocity of 0.7 m/s. The impactor showed a weight loss of approximately 1.2 x 10 to the -9 power gm per impact with the attrition occurring only at the edges. Results from scanning electron microscope analysis, profilometry, and weight measurement are summarized. It is concluded that particles can incur abrasion at Venusian temperatures even with low impact velocities expected for Venus.

  6. Bioelectrical impedance analysis for bovine milk: Preliminary results

    NASA Astrophysics Data System (ADS)

    Bertemes-Filho, P.; Valicheski, R.; Pereira, R. M.; Paterno, A. S.

    2010-04-01

    This work reports the investigation and analysis of bovine milk quality by using biological impedance measurements using electrical impedance spectroscopy (EIS). The samples were distinguished by a first chemical analysis using Fourier transform midinfrared spectroscopy (FTIR) and flow citometry. A set of milk samples (100ml each) obtained from 17 different cows in lactation with and without mastitis were analyzed with the proposed technique using EIS. The samples were adulterated by adding distilled water and hydrogen peroxide in a controlled manner. FTIR spectroscopy and flow cytometry were performed, and impedance measurements were made in a frequency range from 500Hz up to 1MHz with an implemented EIS system. The system's phase shift was compensated by measuring saline solutions. It was possible to show that the results obtained with the Bioelectrical Impedance Analysis (BIA) technique may detect changes in the milk caused by mastitis and the presence of water and hydrogen peroxide in the bovine milk.

  7. Preliminary test results for the small community solar power system

    NASA Astrophysics Data System (ADS)

    Pons, R. L.; Boda, F. P.

    1982-11-01

    The design feature, performance test results, and operational features of a parabolic dish concentrator small community power system being developed at JPL are described. The system, a prototype unit for modular energy systems of less than 10 MWe, uses multiple parabolic sections, a 20 kWe hermetically sealed organic Rankine cycle engine, and a permanent magnet alternator. The power component is a single stage axial flow turbine with an air-cooled condenser. A static dc/ac inverter and additional equipment condition the power for grid interface and synchronization. Software has been developed to permit remote, stand-alone operation, and to obtain steady performance during intermittent clouding. Each power module is equipped with microprocessors for virtually independent functioning. Separate control systems in each concentrator assembly govern positioning, fluid flow rate, and turbine speed. The system has produced 16.2 kWe continuous power at a net overall efficiency of 15.4% of the insolation.

  8. Preliminary results from the MAMA detectors for the SOHO mission

    NASA Technical Reports Server (NTRS)

    Slater, David C.; Bergamini, Paolo; Bumala, Robert W.; Timothy, J. G.

    1993-01-01

    Multi-Anode Microchannel Array (MAMA) detector systems are being fabricated and tested for use in the Solar Ultraviolet Measurements of Emitted Radiation (SUMER) and the Ultraviolet Coronagraph Spectrometer (UVCS) instruments on the ESA/NASA Solar and Heliospheric Observatory (SOHO) mission. The SOHO MAMA detector systems have formats of 360 x 1024 pixels and pixel dimensions of 25 x 25 sq microns and are optimized for operation at Extreme Ultraviolet (EUV) wavelengths between 40 and 160 nm. In this paper we report on the initial results of measurements of the performance characteristics of the first flight-configuration detector system employing the new custom Application Specific Integrated Circuits (ASICs) which are designed to improve both the dynamic range and the uniformity of response. The performance characteristics of this detector system are compared with those of earlier breadboard systems employing discrete-component electronics circuits.

  9. TURBulence Ocean Lidar (TURBOL): preliminary results of laboratory experiments

    NASA Astrophysics Data System (ADS)

    Josset, D. B.; Hou, W.; Goode, W.; Nootz, G.; Matt, S.

    2016-02-01

    Turbulence is a critical property of the ocean mixed layer and has a direct impact on ocean heat storage and algae photosynthesis. Observing changes in turbulence at the synoptic scale is quite challenging. Research vessels provide a limited geographic/temporal coverage and most systems used to characterize turbulence use in situ instrumentations which disturb the flow and affects turbulence itself. Lidar observations are a promising way to study the ocean properties. Polarization is one of the three key properties of light, in addition to intensity and color (frequency). Each of these properties provides different information about the medium the light passes through, however the information provided by polarization is unique in characterizing the properties of the media. Underwater polarization can be used to study the optical signature of inorganic particles in coastal waters from remote sensing and recent research has shown that scattering due to optical turbulence can be expressed as a function of the depolarization rate. The TURBulence Ocean Lidar is an experimental system, aimed at characterizing underwater turbulence by examining various Stokes parameters. In this presentation, we propose to discuss several results from the laboratory setup of the lidar system, including how the polarization signature is affected by the turbulence intensity. Although the effect on the degree of polarization appears to be a monotonic function of turbulence intensity, our results suggest that the way the light intensity shifts between the different Stokes parameter is much more complex. While this is not unexpected from a theoretical point of view, this has different implications on the optimal configurations of ocean lidar system based on polarization.

  10. Sodium and potassium lidar system and preliminary result in Brazil

    NASA Astrophysics Data System (ADS)

    Du, Lifang

    2017-04-01

    This paper reported that the first sodium and potassium lidar was built at November, 2016 in INPE(S23°,W45°) by National Space Science Center, Chinese Academy of Sciences. This system first time realized the potassium and sodium metal layer at the same time above the detection In South America. The lidar system use a powerful pulse YAG laser to pumped two dye lasers at the same time, and join the advanced technology, such as narrow line-width grating technique, efficient laser frequency doubling technique, wavelength automatic locking technique and the double optical fiber in the focal plane for spectra separation technique and so on, which made the 589 nm and 770 nm laser line width to achieve 0.03cm-1 and the laser frequency doubling efficiency to reached above 65%. In this way, the simultaneously detecting the atmosphere at the altitude of 80 110 km by sodium and potassium fluorescence in one lidar facility has been realized. On November 20, 2016, this system began to observation for the first time in Brazil, and it has the detection data of South America about potassium and sodium at the same time. Observed data show that sodium echo photon counting rate is higher than 31874count/160s/96m, potassium echo photon counting rate is higher than 2153count/320s/96m. Comparing with both of at home or abroad, the results are a very good. In particular, the detection results level of potassium take the leading position in the international.

  11. NEOWISE OBSERVATIONS OF NEAR-EARTH OBJECTS: PRELIMINARY RESULTS

    SciTech Connect

    Mainzer, A.; Bauer, J.; Masiero, J.; Eisenhardt, P.; Grav, T.; Mo, W.; McMillan, R. S.; Cutri, R. M.; Walker, R.; Wright, E.; Tholen, D. J.; Jedicke, R.; Denneau, L.; Spahr, T.; DeBaun, E.; Elsbury, D.; Gautier, T.; Gomillion, S.; Hand, E.; Watkins, J.; and others

    2011-12-20

    With the NEOWISE portion of the Wide-field Infrared Survey Explorer (WISE) project, we have carried out a highly uniform survey of the near-Earth object (NEO) population at thermal infrared wavelengths ranging from 3 to 22 {mu}m, allowing us to refine estimates of their numbers, sizes, and albedos. The NEOWISE survey detected NEOs the same way whether they were previously known or not, subject to the availability of ground-based follow-up observations, resulting in the discovery of more than 130 new NEOs. The survey's uniform sensitivity, observing cadence, and image quality have permitted extrapolation of the 428 near-Earth asteroids (NEAs) detected by NEOWISE during the fully cryogenic portion of the WISE mission to the larger population. We find that there are 981 {+-} 19 NEAs larger than 1 km and 20,500 {+-} 3000 NEAs larger than 100 m. We show that the Spaceguard goal of detecting 90% of all 1 km NEAs has been met, and that the cumulative size distribution is best represented by a broken power law with a slope of 1.32 {+-} 0.14 below 1.5 km. This power-law slope produces {approx}13, 200 {+-} 1900 NEAs with D > 140 m. Although previous studies predict another break in the cumulative size distribution below D {approx} 50-100 m, resulting in an increase in the number of NEOs in this size range and smaller, we did not detect enough objects to comment on this increase. The overall number for the NEA population between 100 and 1000 m is lower than previous estimates. The numbers of near-Earth comets and potentially hazardous NEOs will be the subject of future work.

  12. Preliminary results of hydrogeologic investigations Humboldt River Valley, Winnemucca, Nevada

    USGS Publications Warehouse

    Cohen, Philip M.

    1964-01-01

    . The resulting increase of the stage of the river causes the river to lose large amounts of water by infiltration to the ground-water reservoir in the study area. In addition, there is much recharge to the ground-water reservoir in the spring and early summer as a result of seepage losses from irrigation ditches and the downward percolation of some of the excess water applied for irrigation. The average net increase of ground water in storage in the deposits beneath and adjacent to the flood plain of the Humboldt River during the spring and early summer is about 10,000 acre-feet.

  13. Preliminary Seafloor Controlled Source EM Results From APPLE

    NASA Astrophysics Data System (ADS)

    Behrens, J. P.; MacGregor, L.; Constable, S.; Everett, M.

    2001-12-01

    Certain events in the life cycle of oceanic lithosphere are dominantly two-dimensional. These include formation of crust at axial spreading centers and deformation at the lithosphere - asthenosphere boundary. These processes may result in an electrically anisotropic oceanic lithosphere by creating conductive pathways in preferred orientations. Controlled Source Electromagnetic (CSEM) soundings and Magnetotelluric (MT) soundings were made during the Anisotropy and Physics of the Pacific Lithosphere Experiment (APPLE), carried out in February/March 2001 approximately 600 km west of San Diego, California. Twenty seafloor electromagnetic field sensors were deployed: 4 long-wire CSEM recorders with 200 m electrode offsets, 6 high-frequency MT/CSEM recorders with two orthogonal 10 m offset electrodes and two orthogonal induction coil magnetometers, and 10 low-frequency MT recorders with a three-component fluxgate magnetometer and two orthogonal 10 m electric dipoles, 5 of which also recorded CSEM data. Every instrument was recovered, with data, during this primary cruise and a follow-up recovery cruise for the long-period instruments in August 2001. The deep-towed EM transmitter (DASI) was a 100 m horizontal electric dipole, which was towed in a 30 km radius circle around a central core of recorders. A radial tow was also performed. DASI transmitted a 4 Hz square wave throughout the CSEM phase of the experiment. Initial processing of the CSEM data reveals evidence of crustal anisotropy. In particular, transmitted electromagnetic energy is attenuated more strongly when propagating from west to east than from north to south. The difference in attenuation is about a factor of two, at a range of 30 km and a frequency of 4Hz. This confirms earlier results from the PEGASUS experiment, which proposed that oceanic lower crust and upper mantle with east-west trending lineaments of increased conductivity will exhibit greater attenuation of electric fields in the east

  14. Preliminary results from the heavy ions in space experiment

    NASA Technical Reports Server (NTRS)

    Adams, James H., Jr.; Beahm, Lorraine P.; Tylka, Allan J.

    1992-01-01

    The Heavy Ions In Space (HIIS) experiment has two primary objectives: (1) to measure the elemental composition of ultraheavy galactic cosmic rays, beginning in the tin-barium region of the periodic table; and (2) to study heavy ions which arrive at LDEF below the geomagnetic cutoff, either because they are not fully stripped of electrons or because their source is within the magnetosphere. Both of these objectives have practical as well as astrophysical consequences. In particular, the high atomic number of the ultraheavy galactic cosmic rays puts them among the most intensely ionizing particles in Nature. They are therefore capable of upsetting electronic components normally considered immune to such effects. The below cutoff heavy ions are intensely ionizing because of their low velocity. They can be a significant source of microelectronic anomalies in low inclination orbits, where Earth's magnetic field protects satellites from most particles from interplanetary space. The HIIS results will lead to significantly improved estimates of the intensely ionizing radiation environment.

  15. Geochemistry of shale groundwaters: Results of preliminary laboratory leaching experiments

    SciTech Connect

    Von Damm, K.L.; Johnson, K.O.

    1987-09-01

    Twelve shales were reacted with distilled water at 20/sup 0/C and 100/sup 0/C; the composition of the waters and the mineralogy were determined before and after reaction. The experiments were conducted in a batch mode over a period of approximately 40 days. Major changes occurred in the solution chemistry; in most cases sulfate became the dominant anion while either sodium or calcium was the major cation. The high sulfate is most likely a result of the oxidation of pyrite in the samples. In the 100/sup 0/C experiments some of the solutions became quite acidic. Examination of the observed mineralogy and comparison to the mineral assemblage calculated to be in equilibrium with the experimentally determined waters, suggests that the acidic waters are generated when no carbonate minerals remain to buffer the groundwaters to a more neutral pH. The pH of shale waters will be determined by the balance between the oxidation of pyrite and organic matter and the dissolution of carbonate minerals. The experimental data are helping to elucidate the chemical reactions that control the pH of shale groundwaters, a critical parameter in determining other water-rock and waste-water-rock interactions and ultimate solute mobility. An experimental approach also provides a means of obtaining data for shales for which no groundwater data are available as well as data on chemical species which are not usually determined or reported.

  16. Magnetic field studies by voyager 1: preliminary results at saturn.

    PubMed

    Ness, N F; Acuña, M H; Lepping, R P; Connerney, J E; Behannon, K W; Burlaga, L F; Neubauer, F M

    1981-04-10

    Magnetic field studies by Voyager 1 have confirmed and refined certain general features of the Saturnian magnetosphere and planetary magnetic field established by Pioneer 11 in 1979. The main field of Saturn is well represented by a dipole of moment 0.21 +/- 0.005 gauss-R(s)(3) (where 1 Saturn radius, R(s), is 60,330 kilometers), tilted 0.7 degrees +/- 0.35 degrees from the rotation axis and located within 0.02 R(s) of the center of the planet. The radius of the magnetopause at the subsolar point was observed to be 23 R(s) on the average, rather than 17 R(s). Voyager 1 discovered a magnetic tail of Saturn with a diameter of approximately 80 R(s). This tail extends away from the Sun and is similar to type II comet tails and the terrestrial and Jovian magnetic tails. Data from the very close flyby at Titan (located within the Saturnian magnetosphere) at a local time of 1330, showed an absence of any substantial intrinsic satellite magnetic field. However, the results did indicate a very well developed, induced magnetosphere with a bipolar magnetic tail. The upper limit to any possible internal satellite magnetic moment is 5 x 10(21) gauss-cubic centimeter, equivalent to a 30-nanotesla equatorial surface field.

  17. Magnetic field studies by voyager 2: preliminary results at saturn.

    PubMed

    Ness, N F; Acuna, M H; Behannon, K W; Burlaga, L F; Connerney, J E; Lepping, R P; Neubauer, F M

    1982-01-29

    Further studies of the Saturnian magnetosphere and planetary magnetic field by Voyager 2 have substantiated the earlier results derived from Voyager 1 observations in 1980. The magnetic field is primarily that of a centered dipole (moment = 0.21 gauss-RS(3); where one Saturn radius, RS, is 60,330 kilometers) tilted approximately 0.8 degrees from the rotation axis. Near closest approach to Saturn, Voyager 2 traversed a kronographic longitude and latitude range that was complementary to that of Voyager 1. Somewhat surprisingly, no evidence was found in the data or the analysis for any large-scale magnetic anomaly in the northern hemisphere which could be associated with the periodic modulation of Saturnian kilometric radiation radio emissions. Voyager 2 crossed the magnetopause of a relatively compressed Saturnian magnetosphere at 18.5 RS while inbound near the noon meridian. Outbound, near the dawn meridian, the magnetosphere had expanded considerably and the magnetopause boundary was not observed until the spacecraft reached 48.4 to 50.9 RS and possibly beyond. Throughout the outbound magnetosphere passage, a period of 46 hours (4.5 Saturn rotations), the field was relatively steady and smooth showing no evidence for any azimuthal asymmetry or magnetic anomaly in the planetary field. We are thus left with a rather enigmatic situation to understand the basic source of Saturnian kilometric radiation modulation, other than the small dipole tilt.

  18. Magnetic field studies at jupiter by voyager 2: preliminary results.

    PubMed

    Ness, N F; Acuna, M H; Lepping, R P; Burlaga, L F; Behannon, K W; Neubauer, F M

    1979-11-23

    Data from the Goddard Space Flight Center magnetometers on Voyager 2 have yielded on inbound trajectory observations of multiple crossings of the bow shock and magnetosphere near the Jupiter-sun line at radial distances of 99 to 66 Jupiter radii (RJ) and 72 to 62 RJ, respectively. While outbound at a local hour angle of 0300, these distances increase appreciably so that at the time of writing only the magnetopause has been observed between 160 and 185 RJ. These results and the magnetic field geometry confirm the earlier conclusion from Voyager I studies that Jupiter has an enormous magnetic tail, approximately 300 to 400 RJ in diameter, trailing behind the planet with respect to the supersonic flow of the solar wind. Addi- tional observations of the distortion of the inner magnetosphere by a concentrated plasma show a spatial merging of the equatorial magnetodisk current with the cur- rent sheet in the magnetic tail. The spacecraft passed within 62,000 kilometers of Ganymede (radius = 2,635 kilometers) and observed characteristic fluctuations in- terpreted tentatively as being due to disturbances arising from the interaction of the Jovian magnetosphere with Ganymede.

  19. Eight Pulse Performance of DARHT Axis II - Preliminary Results

    SciTech Connect

    Schulze, Martin E.

    2015-12-08

    The DARHT-II accelerator produces a 1.65-kA, 17-MeV beam in a 1600-ns pulse. Standard operation of the DARHT Axis II accelerator involves extracting four short pulses from the 1.6 us long macro-pulse produced by the LIA. The four short pulses are extracted using a fast kicker in combination with a quadrupole septum magnet and then transported for several meters to a high-Z material target for conversion to x-rays for radiography. The ability of the DARHT Axis 2 kicker to produce more than the standard four pulse format has been previously demonstrated. This capability was developed to study potential risks associated with beam transport during an initial commissioning phase at low energy (8 MeV) and low current (1.0 kA).The ability of the kicker to deliver more than four pulses to the target has been realized for many years. This note describes the initial results demonstrating this capability.

  20. Steady-state flow of solid CO2: preliminary results

    USGS Publications Warehouse

    Durham, William B.; Kirby, Stephen H.; Stern, Laura A.

    1999-01-01

    To help answer the question of how much solid CO2 exists in the Martian south polar cap, we performed a series of laboratory triaxial deformation experiments at constant displacement rate in compression on jacketed cylinders of pure, polycrystalline CO2. Test conditions were temperatures 150 −8 ≤ ε ≤4.3×10−4 s−1. Most of the measurements follow a constitutive law of the form ε = Aσnexp(−Q/RT), where σ is the applied differential stress, R is the gas constant, and the other constants have values as follows: A = 103 86 MPa−ns−1, n = 5.6, and Q = 33 kJ/mol. Solid CO2 is markedly weaker than water ice. Our results suggest that the south polar cap on Mars is unlikely to be predominately solid CO2, because the elevation and estimated age of the cap is difficult to reconcile with the very weak rheology of the material.

  1. Telerobotic field geologist - Preliminary results of a feasibility study

    NASA Technical Reports Server (NTRS)

    Cole, Robert E.; Albert-Thenet, Charlotte; Taylor, G. J.; Johnson, Paul; Buzan, Forrest; Ishigo, Joy; Ikehara, Curtis

    1992-01-01

    Results of three laboratory studies conducted to explore the feasibility of developing a telerobot to perform planetary field geology are presented. A total of 72 college students attempted to match each of 15 geologic rock samples viewed either directly or on a TV screen with its matched pair contained in a matrix of 24 rocks which they viewed directly. The first study showed that rocks viewed on TV could be matched at levels well above chance, but significantly less than by direct view. Performance under remote view was improved by adding color and by magnifying the TV image. The second study showed a large decrease in performance when viewing a miniature LCK monitor as compared to a 19-in. CRT monitor of higher resolution. In the third study performance using the 2.9-in. LCK monitor showed only insignificant increases when images were presented in 3D view or when the rock was moved. It is suggested that it is feasible to conduct geologic observations with telerobots, and the critical role that image quality plays in determining performance is demonstrated.

  2. Preliminary Benchmarking Efforts and MCNP Simulation Results for Homeland Security

    SciTech Connect

    Robert Hayes

    2008-04-18

    It is shown in this work that basic measurements made from well defined source detector configurations can be readily converted in to benchmark quality results by which Monte Carlo N-Particle (MCNP) input stacks can be validated. Specifically, a recent measurement made in support of national security at the Nevada Test Site (NTS) is described with sufficient detail to be submitted to the American Nuclear Society’s (ANS) Joint Benchmark Committee (JBC) for consideration as a radiation measurement benchmark. From this very basic measurement, MCNP input stacks are generated and validated both in predicted signal amplitude and spectral shape. Not modeled at this time are those perturbations from the more recent pulse height light (PHL) tally feature, although what spectral deviations are seen can be largely attributed to not including this small correction. The value of this work is as a proof-of-concept demonstration that with well documented historical testing can be converted into formal radiation measurement benchmarks. This effort would support virtual testing of algorithms and new detector configurations.

  3. Preliminary Results on Compton Electrons in Silicon Drift Detector

    NASA Astrophysics Data System (ADS)

    Conka-Nurdan, T.; Nurdan, K.; Laihem, K.; Walenta, A. H.; Fiorini, C.; Freisleben, B.; Hornel, N.; Pavel, N. A.; Struder, L.

    2004-10-01

    Silicon drift detectors (SDD) with on-chip electronics have found many applications in different fields. A detector system has recently been designed and built to study the electrons from Compton scatter events in such a detector. The reconstruction of the Compton electrons is a crucial issue for Compton imaging. The equipment consists of a monolithic array of 19 channel SDDs and an Anger camera. Photons emitted from a finely collimated source undergo Compton scattering within the SDD where the recoil electron is absorbed. The scattered photon is subsequently observed by photoelectric absorption in the second detector. The coincidence events are used to get the energy, position, and direction of the Compton electrons. Because the on-chip transistors provide the first stage amplification, the SDDs provide outstanding noise performance and fast shaping, so that very good energy resolution can be obtained even at room temperature. The drift detectors require a relatively low number of readout channels for large detector areas. Custom-designed analog and digital electronics provide fast readout of the SDDs. The equipment is designed such that the measurements can be done in all detector orientations and kinematical conditions. The first results obtained with this detector system will be presented in this paper.

  4. Ionospheric scintillation observations over Kenyan region - Preliminary results

    NASA Astrophysics Data System (ADS)

    Olwendo, O. J.; Xiao, Yu; Ming, Ou

    2016-11-01

    Ionospheric scintillation refers to the rapid fluctuations in the amplitude and phase of a satellite signal as it passes through small-scale plasma density irregularities in the ionosphere. By analyzing ionospheric scintillation observation datasets from satellite signals such as GPS signals we can study the morphology of ionospheric bubbles. At low latitudes, the diurnal behavior of scintillation is driven by the formation of large-scale equatorial density depletions which form one to two hours after sunset via the Rayleigh-Taylor instability mechanism near the magnetic equator. In this work we present ionospheric scintillation activity over Kenya using data derived from a newly installed scintillation monitor developed by CRIRP at Pwani University (39.78°E, 3.24°S) during the period August to December, 2014. The results reveal the scintillation activity mainly occurs from post-sunset to post-midnight hours, and ceases around 04:00 LT. We also found that the ionospheric scintillation tends to appear at the southwest and northwest of the station. These locations coincide with the southern part of the Equatorial Ionization Anomaly crest over Kenya region. The occurrence of post-midnight L-band scintillation events which are not linked to pre-midnight scintillation observations raises fundamental question on the mechanism and source of electric fields driving the plasma depletion under conditions of very low background electron density.

  5. Preliminary results Skylab experiment TO27 optical contamination in space

    NASA Technical Reports Server (NTRS)

    Muscari, J. A.; Jambor, B. J.; Westcott, P. A.

    1974-01-01

    Current results from the TO27 experiment which was performed on the first two Skylab missions are presented. The purpose of the experiment was to determine the change in optical properties of various transmissive windows, mirrors, and diffraction gratings caused by the deposition of contaminants found about the orbital assembly and to measure the sky brightness background caused by solar illumination of particulate contaminants. The sample array system containing 248 optical surfaces and exposed outside the orbital workshop did not collect any significant contaminants. Only trace amounts of surface deposited contaminants have been seen, in all cases the measurement was near the limiting sensitivity of the instrument. Unfortunate performance compromises and the relative cleanliness of the assembly on the anti-solar side appeared to place the amount of available surface contaminants near the limiting sensitivity of the sample array. Mass spectroscopy on the trace contaminants show the presence of high molecular weight species, up to 773 amu. The data suggests the presence of condensed aromatics.

  6. Preliminary results Skylab experiment TO27 optical contamination in space

    NASA Technical Reports Server (NTRS)

    Muscari, J. A.; Jambor, B. J.; Westcott, P. A.

    1974-01-01

    Current results from the TO27 experiment which was performed on the first two Skylab missions are presented. The purpose of the experiment was to determine the change in optical properties of various transmissive windows, mirrors, and diffraction gratings caused by the deposition of contaminants found about the orbital assembly and to measure the sky brightness background caused by solar illumination of particulate contaminants. The sample array system containing 248 optical surfaces and exposed outside the orbital workshop did not collect any significant contaminants. Only trace amounts of surface deposited contaminants have been seen, in all cases the measurement was near the limiting sensitivity of the instrument. Unfortunate performance compromises and the relative cleanliness of the assembly on the anti-solar side appeared to place the amount of available surface contaminants near the limiting sensitivity of the sample array. Mass spectroscopy on the trace contaminants show the presence of high molecular weight species, up to 773 amu. The data suggests the presence of condensed aromatics.

  7. The CoRoT Mission - Status and Preliminary Results

    NASA Astrophysics Data System (ADS)

    Fridlund, M.

    2007-08-01

    The CoRoT (Convection, Rotation and planetary Transits) space mission is the first dedicated space mission designed to search for exo-planets akin to our own. It is a joint effort by France, Austria Belgium, Brazil, Germany, Spain and the European Space Agency. It is specifically designed to search for exo-planets much smaller than hitherto discovered. It was launched in December 2006 on a mission lasting not less than 3 years. Verification and first operations have proven the mission to superceed all expectations. This is of course most relevant in the fact that planets as small as our own Earth are detectable. In this presentation we describe the experiences of the first 6 mo0nths of the mission, the actual status of the mission, the supporting ground based program, and what we expect in the near future. After giving examples of data relevant to the topic of this session, we turn to describing the expected impact of the results of CoRoT on future endeavours such as KEPLER, Extremely Large Telescopes (ELT's) and ultimately Darwin.

  8. Use of remote sensing in ecological research: preliminary results

    NASA Astrophysics Data System (ADS)

    Casucci, Francesca; Caporali, Enrica; Lebboroni, Marco; Profeti, Giuliana

    1998-12-01

    The spatial distribution of birds is an important parameter in the analysis of terrestrial systems; in this study its relationship with satellite-derived vegetation data has been demonstrated. In the present work four Landsat Thematic Mapper (TM) images were used to obtain the Normalized Difference Vegetation Index (NDVI) and the Leaf Water Content Index (LWCI), plus three structure indices based on a land use map. A hierarchical cluster analysis of these indices allowed the identification of four main clusters that were compared to the results of a set of vegetation and ornithological samples, taken in the period of May-June 1997. The procedure used in this study has allowed the individuation of environmental topologies with ecological relevance from satellite imagery. The typification of the environment leads to the formulation of faunistic prediction models in terms of ornithic composition. The avifauna predictability permits, at last, the set-up of proceedings for the environment quality evaluation in terrestrial systems, whenever standard scores for the species would be stated.

  9. Telerobotic field geologist - Preliminary results of a feasibility study

    NASA Technical Reports Server (NTRS)

    Cole, Robert E.; Albert-Thenet, Charlotte; Taylor, G. J.; Johnson, Paul; Buzan, Forrest; Ishigo, Joy; Ikehara, Curtis

    1992-01-01

    Results of three laboratory studies conducted to explore the feasibility of developing a telerobot to perform planetary field geology are presented. A total of 72 college students attempted to match each of 15 geologic rock samples viewed either directly or on a TV screen with its matched pair contained in a matrix of 24 rocks which they viewed directly. The first study showed that rocks viewed on TV could be matched at levels well above chance, but significantly less than by direct view. Performance under remote view was improved by adding color and by magnifying the TV image. The second study showed a large decrease in performance when viewing a miniature LCK monitor as compared to a 19-in. CRT monitor of higher resolution. In the third study performance using the 2.9-in. LCK monitor showed only insignificant increases when images were presented in 3D view or when the rock was moved. It is suggested that it is feasible to conduct geologic observations with telerobots, and the critical role that image quality plays in determining performance is demonstrated.

  10. Methane in permafrost - Preliminary results from coring at Fairbanks, Alaska

    USGS Publications Warehouse

    Kvenvolden, K.A.; Lorenson, T.D.

    1993-01-01

    Permafrost has been suggested as a high-latitude source of methane (a greenhouse gas) during global warming. To begin to assess the magnitude of this source, we have examined the methane content of permafrost in samples from shallow cores (maximum depth, 9.5m) at three sites in Fairbanks, Alaska, where discontinuous permafrost is common. These cores sampled frozen loess, peat, and water (ice) below the active layer. Methane contents of permafrost range from <0.001 to 22.2mg/kg of sample. The highest methane content of 22.2mg/kg was found in association with peat at one site. Silty loess had high methane contents at each site of 6.56, 4.24, and 0.152mg/kg, respectively. Carbon isotopic compositions of the methane (??13C) ranged from -70.8 to -103.9 ???, and hydrogen isotopic compositions of the methane (??D) from -213 to -313 ???, indicating that the methane is microbial in origin. The methane concentrations were used in a one dimensional heat conduction model to predict the amount of methane that will be released from permafrost worldwide over the next 100 years, given two climate change scenarios. Our results indicate that at least 30 years will elapse before melting permafrost releases important amounts of methane; a maximum methane release rate will be about 25 to 30 Tg/yr, assuming that methane is generally distributed in shallow permafrost as observed in our samples.

  11. Ultrasound-only dosimetry for prostate brachytherapy: preliminary phantom results

    NASA Astrophysics Data System (ADS)

    Wen, Xu; Salcudean, S. E.; Lawrence, P. D.; Morris, J.

    2007-03-01

    Accurate and fast seed localization plays a key role in computing dosimetry for prostate brachytherapy. Because transrectal ultrasound is the primary imaging modality providing the guidance for prostate brachytherapy, an ultrasound-only approach for dosimetry would offer many benefits. In this paper, we propose an ultrasound only dosimetry solution, in which the brachytherapy seeds are located in reflected power images computed from ultrasonic radio frequency signals and the boundary of the prostate is delineated from B-mode TRUS and vibroelastography images as the prostate is stiffer than the surrounding tissue. The location of the implanted seeds relative to the prostate boundary is thus obtained. As only one imaging modality, ultrasound, is used, image registration is easy to implement. A prostate phantom with seeds embedded within it was built to evaluate the proposed approach. To measure the seed localization accuracy in the reflected power images, the phantom was scanned by CT as well. Experimental results show that the implanted seeds can be successfully located in the reflected power images with high contrast and accuracy, and that the contour of the "prostate" can be detected in the ultrasound vibro-elastography images outside the shadow of the seeds.

  12. Solar System Observations with Spitzer Space Telescope: Preliminary Results

    NASA Technical Reports Server (NTRS)

    Cruikshank, Dale P.

    2005-01-01

    The programs of observations of Solar System bodies conducted in the first year of the operation of the Spitzer Space Telescope as part of the Guaranteed Observing Time allocations are described. Initial results include the determination of the albedos of a number of Kuiper Belt objects and Centaurs from observations of their flux densities at 24 and 70 microns, and the detection of emission bands in the spectra of several distant asteroids (Trojans) around 10 and 25 microns. The 10 Kuiper Belt objects observed to date have albedos in the range 0.08 - 0.15, significantly higher than the earlier estimated 0.04. An additional KBO [(55565) 2002 AW(sub l97)] has an albedo of 0.17 plus or minus 0.03. The emission bands in the asteroid spectra are indicative of silicates, but specific minerals have not yet been identified. The Centaur/comet 29P/Schwassmann-Wachmann 1 has a nucleus surface albedo of 0.025 plus or minus 0.01, and its dust production rate was calculated from the properties of the coma. Several other investigations are in progress as the incoming data are processed and analyzed.

  13. MIF in Volcanic Sulfate: Preliminary Results From Greenland Ice Cores

    NASA Astrophysics Data System (ADS)

    Lanciki, A. L.; Cole-Dai, J.; Savarino, J.; Thiemens, M.

    2008-12-01

    Sulfur dioxide from natural and anthropogenic sources is oxidized in the atmosphere to form sulfuric acid aerosols. These aerosols contribute to acid rain, global climate variations, and are a health hazard to humans. Sulfuric acid aerosols in the stratosphere may also affect ozone levels. Volcanic eruptions are a natural source of sulfur dioxide, but depending on the height of the eruption plume, an eruption can be either tropospheric or stratospheric. It has been found in Antarctic ice cores that sulfate from a stratospheric eruption contains sulfur-33 MIF anomaly, while there is no anomaly when sulfur dioxide is oxidized in the troposphere. The unique sulfur MIF signature for stratospheric eruptions could be a valuable tool to identify large, climate-impacting stratospheric eruptions in ice core records. Modeling studies suggest that the main cause of this sulfur MIF is photochemical reactions induced by high-energy UV light below 310 nm. This is consistent with the Antarctica ice core results that the sulfur anomaly is found only in eruptions that emitted sulfur dioxide directly into the stratosphere, where substantial UV radiation is available. In this work, volcanic sulfate from a few volcanic eruptions has been extracted from a number of Greenland ice cores and analyzed for sulfur anomaly. For the first time, MIF anomaly has been found in the sulfate of a known stratospheric eruption (the 1815 Tambora eruption) preserved in the Northern Hemisphere. These latest data show that the pattern of sulfur anomaly evolution during the deposition of volcanic sulfate is similar at both polar regions. This provides further evidence that sulfur MIF anomaly is generated by photochemical reactions and dynamic processes in the global stratosphere.

  14. Preliminary results on noncollocated torque control of space robot actuators

    NASA Technical Reports Server (NTRS)

    Tilley, Scott W.; Francis, Colin M.; Emerick, Ken; Hollars, Michael G.

    1989-01-01

    In the Space Station era, more operations will be performed robotically in space in the areas of servicing, assembly, and experiment tending among others. These robots may have various sets of requirements for accuracy, speed, and force generation, but there will be design constraints such as size, mass, and power dissipation limits. For actuation, a leading motor candidate is a dc brushless type, and there are numerous potential drive trains each with its own advantages and disadvantages. This experiment uses a harmonic drive and addresses some inherent limitations, namely its backdriveability and low frequency structural resonances. These effects are controlled and diminished by instrumenting the actuator system with a torque transducer on the output shaft. This noncollocated loop is closed to ensure that the commanded torque is accurately delivered to the manipulator link. The actuator system is modelled and its essential parameters identified. The nonlinear model for simulations will include inertias, gearing, stiction, flexibility, and the effects of output load variations. A linear model is extracted and used for designing the noncollocated torque and position feedback loops. These loops are simulated with the structural frequency encountered in the testbed system. Simulation results are given for various commands in position. The use of torque feedback is demonstrated to yield superior performance in settling time and positioning accuracy. An experimental setup being finished consists of a bench mounted motor and harmonic drive actuator system. A torque transducer and two position encoders, each with sufficient resolution and bandwidth, will provide sensory information. Parameters of the physical system are being identified and matched to analytical predictions. Initial feedback control laws will be incorporated in the bench test equipment and various experiments run to validate the designs. The status of these experiments is given.

  15. Preliminary Results from Coordinated UVCS-CDS-Ulysses Observations

    NASA Technical Reports Server (NTRS)

    Parenti, S.; Bromage, B. J.; Poletto, G.; Suess, S. T.; Raymond, J. C.; Noci, G.; Bromage, G. E.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    The June 2000 quadrature between the Sun, Earth, and Ulysses took place with Ulysses at a distance of 3.35 AU from the Sun and at heliocentric latitude 58.2 deg south, in the southeast quadrant. This provided an opportunity to observe the corona close to the Sun with Coronal Diagnostic Spectrometer (CDS) and Ultraviolet Coronograph Spectrometer (UVCS) and, subsequently, to sample the same plasma when it reached Ulysses. Here we focus on simultaneous observations of UVCS and CDS made on June 12, 13, 16 and 17. The UVCS data were acquired at heliocentric altitudes ranging from 1.6 to 2.2 solar radii, using different grating positions, in order to get a wide wavelength range. CDS data consisted of Normal Incidence Spectrometer (NIS) full wavelength rasters of 120" x 150" centered at altitudes up to 1.18 solar radii, together with Grazing Incidence Spectrometer (GIS) 4" x 4" rasters within the same field of view, out to 1.2 solar radii. The radial direction to Ulysses passed through a high latitude streamer, throughout the 4 days of observations, Analysis of the spectra taken by UVCS shows a variation of the element abundances in the streamer over our observing interval: however, because the observations were in slightly different parts of the streamer on different days, the variation could be ascribed either to a temporal or spatial effect. The oxygen abundance, however, seems to increase at the edge of the streamer, as indicated by previous analyses. This suggests the variation may be a function of position within the streamer, rather than a temporal effect. Oxygen abundances measured by SWICS on Ulysses are compared with the CDS and UVCS results to see whether changes measured in situ follow the same pattern.

  16. Preliminary results from two international pluvial flood event studies

    NASA Astrophysics Data System (ADS)

    Roezer, Viktor; Spekkers, Matthieu; Kreibich, Heidi

    2016-04-01

    Pluvial floods have caused severe damages to urban dwellings in Europe and elsewhere in recent years. With a predicted increase in extreme weather events as well as an ongoing urbanization, pluvial flood damage is expected to increase in the future. These type of flood events, caused by stormwater being unable to enter urban drainage systems or flowing out of urban drainage systems when capacity is exceeded, often happen with little warning and in areas which are often not obviously prone to flooding. Up to now little research was done on the adverse consequences of pluvial floods, as empirical damage data of pluvial flooding is scarce. In this study, results of two telephone surveys are discussed. The surveys comprise interviews with more than 500 flood-affected households in Germany (Münster and Greven) and the Netherlands (Amsterdam), related to the severe rain event of July 28th 2014. Respondents were asked a series of questions about the damage to their building structure and contents, as well as on topics such as early warning, emergency and precautionary measures, building properties and hazard characteristics. The questionnaire was developed with the aim to create a harmonized transnational pluvial flood damage survey that can potentially be extended to other European countries. New indicator variables have been developed to account for different national and regional standards in building structure, early warning, socio-economic data and recovery. The survey data from the German and Dutch case studies are compared with the goal to identify similarities and differences in damage reducing factors and recovery. Water level data and other hazard characteristics are used to form comparable groups out of the German and Dutch sample. Within these groups, regional distinctions in building topology and use are expected to have the strongest impact on differences between reported damage amounts of the two case studies. The newly collected data will be used in

  17. Crawling wave detection of prostate cancer: preliminary in vitro results.

    PubMed

    An, Liwei; Mills, Bradley; Hah, Zaegyoo; Mao, Shuo; Yao, Jorge; Joseph, Jean; Rubens, Deborah J; Strang, John; Parker, Kevin J

    2011-05-01

    The focus of this article is to develop signal and imaging processing methods to derive an accurate estimation of local tissue elasticity using the crawling wave (CrW) sonoelastography method. The task is to reduce noise and to improve the contrast of the elasticity map. The protocol of the CrW approach was first tested on heterogeneous elastic phantoms as a model of prostate cancers. Then, the contrast-to-noise ratio of the estimation was calculated iteratively with various sequences of algorithms to determine the optimal signal processing settings. Finally, the optimized signal processing was applied to ex vivo prostate cancer detection. The comparison of the segmented elasticity map and the histology tumor outline was made by quadrants to evaluate the diagnostic performance of the protocol. Furthermore, the CrW approach was combined with amplitude-sonoelastography to achieve a higher specificity. This study demonstrated the feasibility of the proposed approach for clinical applications. In the application to ex vivo prostate cancer detection, the established approach was tested on 43 excised prostate glands. The combination of the CrW approach and amplitude-sonoelastography achieved an accuracy of over 80% for finding tumors larger than 4 mm in diameter. The elasticity values and contrast found by the CrW approach were in agreement with the previous results derived from mechanical testing. Crawling waves can be applied to detect prostate cancer with accuracy approaching 80% and can quantify the stiffness or shear modulus of both cancerous and noncancerous tissues. The technique therefore shows promise for guiding biopsies to suspect regions that are otherwise difficult to identify.

  18. Preliminary Results from Coordinated UVCS-CDS-Ulysses Observations

    NASA Technical Reports Server (NTRS)

    Parenti, S.; Bromage, B. J.; Poletto, G.; Suess, S. T.; Raymond, J. C.; Noci, G.; Bromage, G. E.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    The June 2000 quadrature between the Sun, Earth, and Ulysses took place with Ulysses at a distance of 3.35 AU from the Sun and at heliocentric latitude 58.2 deg south, in the southeast quadrant. This provided an opportunity to observe the corona close to the Sun with Coronal Diagnostic Spectrometer (CDS) and Ultraviolet Coronograph Spectrometer (UVCS) and, subsequently, to sample the same plasma when it reached Ulysses. Here we focus on simultaneous observations of UVCS and CDS made on June 12, 13, 16 and 17. The UVCS data were acquired at heliocentric altitudes ranging from 1.6 to 2.2 solar radii, using different grating positions, in order to get a wide wavelength range. CDS data consisted of Normal Incidence Spectrometer (NIS) full wavelength rasters of 120" x 150" centered at altitudes up to 1.18 solar radii, together with Grazing Incidence Spectrometer (GIS) 4" x 4" rasters within the same field of view, out to 1.2 solar radii. The radial direction to Ulysses passed through a high latitude streamer, throughout the 4 days of observations, Analysis of the spectra taken by UVCS shows a variation of the element abundances in the streamer over our observing interval: however, because the observations were in slightly different parts of the streamer on different days, the variation could be ascribed either to a temporal or spatial effect. The oxygen abundance, however, seems to increase at the edge of the streamer, as indicated by previous analyses. This suggests the variation may be a function of position within the streamer, rather than a temporal effect. Oxygen abundances measured by SWICS on Ulysses are compared with the CDS and UVCS results to see whether changes measured in situ follow the same pattern.

  19. The Hyperspectral Thermal Emission Spectrometer (HyTES): Preliminary Results

    NASA Technical Reports Server (NTRS)

    Hook, Simon; Johnson, William R.; Eng, Bjorn T.; Gunapala, Sarah D.; Lamborn, Andrew U.; Mouroulis, Pantazis, Z.; Mouroulis, Pantazis, Z.; Paine, Christopher G.; Soibel, Alexander; Wilson, Daniel W.

    2011-01-01

    The Hyperspectral Thermal Emission Spectrometer (HyTES) is being developed as part of the risk reduction activities associated with the Hyperspectral Infrared Imager (HyspIRI). HyspIRI is one of the Tier 2 Decadal Survey Missions. HyTES will provide information on how to place the filters on the HyspIRI Thermal Infrared Instrument (TIR) as well as provide antecedent science data. The pushbroom design has 512 spatial pixels over a 50-degree field of view and 256 spectral channels between 7.5 micrometers to 12 micrometers. HyTES includes many key enabling state-of-the-art technologies including a high performance convex diffraction grating, a quantum well infrared photodetector (QWIP) focal plane array, and a compact Dyson-inspired optical design. The Dyson optical design allows for a very compact and optically fast system (F/1.6). It also minimizes cooling requirements due to the fact it has a single monolithic prism-like grating design which allows baffling for stray light suppression. The monolithic configuration eases mechanical tolerancing requirements which are a concern since the complete optical assembly is operated at cryogenic temperatures ((is) approximately 100K). The QWIP allows for optimum spatial and spectral uniformity and provides adequate responsivity or D-star to allow 200mK noise equivalent temperature difference (NEDT) operation across the LWIR passband. Assembly of the system is nearly complete. After completion, alignment results will be presented which show low keystone and smile distortion. This is required to minimize spatial-spectral mixing between adjacent spectral channels and spatial positions. Predictions show the system will have adequate signal to noise for laboratory calibration targets.

  20. Flight Test 4 Preliminary Results: NASA Ames SSI

    NASA Technical Reports Server (NTRS)

    Isaacson, Doug; Gong, Chester; Reardon, Scott; Santiago, Confesor

    2016-01-01

    Realization of the expected proliferation of Unmanned Aircraft System (UAS) operations in the National Airspace System (NAS) depends on the development and validation of performance standards for UAS Detect and Avoid (DAA) Systems. The RTCA Special Committee 228 is charged with leading the development of draft Minimum Operational Performance Standards (MOPS) for UAS DAA Systems. NASA, as a participating member of RTCA SC-228 is committed to supporting the development and validation of draft requirements as well as the safety substantiation and end-to-end assessment of DAA system performance. The Unmanned Aircraft System (UAS) Integration into the National Airspace System (NAS) Project conducted flight test program, referred to as Flight Test 4, at Armstrong Flight Research Center from April -June 2016. Part of the test flights were dedicated to the NASA Ames-developed Detect and Avoid (DAA) System referred to as JADEM (Java Architecture for DAA Extensibility and Modeling). The encounter scenarios, which involved NASA's Ikhana UAS and a manned intruder aircraft, were designed to collect data on DAA system performance in real-world conditions and uncertainties with four different surveillance sensor systems. Flight test 4 has four objectives: (1) validate DAA requirements in stressing cases that drive MOPS requirements, including: high-speed cooperative intruder, low-speed non-cooperative intruder, high vertical closure rate encounter, and Mode CS-only intruder (i.e. without ADS-B), (2) validate TCASDAA alerting and guidance interoperability concept in the presence of realistic sensor, tracking and navigational errors and in multiple-intruder encounters against both cooperative and non-cooperative intruders, (3) validate Well Clear Recovery guidance in the presence of realistic sensor, tracking and navigational errors, and (4) validate DAA alerting and guidance requirements in the presence of realistic sensor, tracking and navigational errors. The results will be