Investigation of a Moire Based Crack Detection Technique for Propulsion Health Monitoring

NASA Technical Reports Server (NTRS)

Woike, Mark R.; Abudl-Aziz, Ali; Fralick, Gustave C.; Wrbanek, John D.

2012-01-01

The development of techniques for the health monitoring of the rotating components in gas turbine engines is of major interest to NASA s Aviation Safety Program. As part of this on-going effort several experiments utilizing a novel optical Moir based concept along with external blade tip clearance and shaft displacement instrumentation were conducted on a simulated turbine engine disk as a means of demonstrating a potential optical crack detection technique. A Moir pattern results from the overlap of two repetitive patterns with slightly different periods. With this technique, it is possible to detect very small differences in spacing and hence radial growth in a rotating disk due to a flaw such as a crack. The experiment involved etching a circular reference pattern on a subscale engine disk that had a 50.8 mm (2 in.) long notch machined into it to simulate a crack. The disk was operated at speeds up to 12 000 rpm and the Moir pattern due to the shift with respect to the reference pattern was monitored as a means of detecting the radial growth of the disk due to the defect. In addition, blade displacement data were acquired using external blade tip clearance and shaft displacement sensors as a means of confirming the data obtained from the optical technique. The results of the crack detection experiments and its associated analysis are presented in this paper.

A spherical electron-channelling pattern map for use in quartz petrofabric analysis

USGS Publications Warehouse

Lloyd, G.E.; Ferguson, C.C.

1986-01-01

Electron channelling patterns (ECP's) are formed in the scanning electron microscope (SEM) by the interaction between the incident electrons and the lattice of crystalline specimens. The patterns are unique for a particular crystallographic orientation and are therefore of considerable potential in petrofabric studies provided they can be accurately indexed. Indexing requires an ECP-map of the crystallographic stereogram or unit triangle covering all possible orientations and hence ECP patterns. Due to the presence of long-range distortions in planar ECP-maps, it is more convenient to construct the maps over a spherical surface. This also facilitates the indexing of individual ECP's. A spherical ECP-map for quartz is presented together with an example of its use in petrofabric analysis. ?? 1986.

The analysis method of the DRAM cell pattern hotspot

NASA Astrophysics Data System (ADS)

Lee, Kyusun; Lee, Kweonjae; Chang, Jinman; Kim, Taeheon; Han, Daehan; Hong, Aeran; Kim, Yonghyeon; Kang, Jinyoung; Choi, Bumjin; Lee, Joosung; Lee, Jooyoung; Hong, Hyeongsun; Lee, Kyupil; Jin, Gyoyoung

2015-03-01

It is increasingly difficult to determine degree of completion of the patterning and the distribution at the DRAM Cell Patterns. When we research DRAM Device Cell Pattern, there are three big problems currently, it is as follows. First, due to etch loading, it is difficult to predict the potential defect. Second, due to under layer topology, it is impossible to demonstrate the influence of the hotspot. Finally, it is extremely difficult to predict final ACI pattern by the photo simulation, because current patterning process is double patterning technology which means photo pattern is completely different from final etch pattern. Therefore, if the hotspot occurs in wafer, it is very difficult to find it. CD-SEM is the most common pattern measurement tool in semiconductor fabrication site. CD-SEM is used to accurately measure small region of wafer pattern primarily. Therefore, there is no possibility of finding places where unpredictable defect occurs. Even though, "Current Defect detector" can measure a wide area, every chip has same pattern issue, the detector cannot detect critical hotspots. Because defect detecting algorithm of bright field machine is based on image processing, if same problems occur on compared and comparing chip, the machine cannot identify it. Moreover this instrument is not distinguished the difference of distribution about 1nm~3nm. So, "Defect detector" is difficult to handle the data for potential weak point far lower than target CD. In order to solve those problems, another method is needed. In this paper, we introduce the analysis method of the DRAM Cell Pattern Hotspot.

AD/HD Symptoms and Conduct Problems: Similarities and Differences in Maternal Perceptions

ERIC Educational Resources Information Center

Maniadaki, Katerina; Sonuga-Barke, Edmund; Kakouros, Efthymios; Karaba, Rania

2006-01-01

Several theories attempt to explain the high co-occurrence of Attention Deficit/ Hyperactivity Disorder (AD/HD) and Conduct Problems (CP). A strong possibility is that AD/HD behaviours lead to the development of CP, due to family coercive interaction patterns, maintained through parental false beliefs regarding child problem behaviour. We compared…

Salary Negotiation Patterns between Women and Men in Academic Libraries

ERIC Educational Resources Information Center

Silva, Elise; Galbraith, Quinn

2018-01-01

Due to persistent wage gaps between men and women nationally, and in the field of academic librarianship, researchers wished to study possible issues that contribute to the phenomenon. This study examines the tendency for men and women to negotiate salaries in academic libraries upon hire. Researchers surveyed professional librarians employed in…

Restriction endonuclease analysis of chloroplast DNA in interspecies somatic Hybrids of Petunia.

PubMed

Kumar, A; Cocking, E C; Bovenberg, W A; Kool, A J

1982-12-01

Restriction endonuclease cleavage pattern analysis of chloroplast DNA (cpDNA) of three different interspecific somatic hybrid plants revealed that the cytoplasms of the hybrids contained only cpDNA of P. parodii. The somatic hybrid plants analysed were those between P. parodii (wild type) + P. hybrida (wild type); P. parodii (wild type)+P. inflata (cytoplasmic albino mutant); P. parodii (wild type) + P. parviflora (nuclear albino mutant). The presence of only P. parodii chloroplasts in the somatic hybrid of P. parodii + P. inflata is possibly due to the stringent selection used for somatic hybrid production. However, in the case of the two other somatic hybrids P. parodii + P. hybrida and P. parodii + P. parviflora it was not possible to determine whether the presence of only P. parodii chloroplasts in these somatic hybrid plants was due to the nature of the selection schemes used or simply occurred by chance. The relevance of such somatic hybrid material for the study of genomic-cytoplasmic interaction is discussed, as well as the use of restriction endonuclease fragment patterns for the analysis of taxonomic and evolutionary inter-relationships in the genus Petunia.

Thermal effects in nano-sized adsorbate islands growth processes at vapor deposition

NASA Astrophysics Data System (ADS)

Kharchenko, Vasyl O.; Kharchenko, Dmitrii O.; Dvornichenko, Alina V.

2016-02-01

We study a model of pattern formation in adsorptive systems with a local change in the surface temperature due to adsorption/desorption processes. It is found that thermal effects shrink the domain of main system parameters, when pattern formation is possible. It is shown that an increase in a surface reheat efficiency delays ordering processes. We have found that a distribution of adsorbate islands over sizes depends on relaxation and reheat processes. We have shown that the mean linear size of stationary adsorbate islands is of nano-meter range.

Control of the ZnO nanowires nucleation site using microfluidic channels.

PubMed

Lee, Sang Hyun; Lee, Hyun Jung; Oh, Dongcheol; Lee, Seog Woo; Goto, Hiroki; Buckmaster, Ryan; Yasukawa, Tomoyuki; Matsue, Tomokazu; Hong, Soon-Ku; Ko, HyunChul; Cho, Meoung-Whan; Yao, Takafumi

2006-03-09

We report on the growth of uniquely shaped ZnO nanowires with high surface area and patterned over large areas by using a poly(dimethylsiloxane) (PDMS) microfluidic channel technique. The synthesis uses first a patterned seed template fabricated by zinc acetate solution flowing though a microfluidic channel and then growth of ZnO nanowire at the seed using thermal chemical vapor deposition on a silicon substrate. Variations the ZnO nanowire by seed pattern formed within the microfluidic channel were also observed for different substrates and concentrations of the zinc acetate solution. The photocurrent properties of the patterned ZnO nanowires with high surface area, due to their unique shape, were also investigated. These specialized shapes and patterning technique increase the possibility of realizing one-dimensional nanostructure devices such as sensors and optoelectric devices.

Common Warming Pattern Emerges Irrespective of Forcing Location

NASA Astrophysics Data System (ADS)

Kang, Sarah M.; Park, Kiwoong; Jin, Fei-Fei; Stuecker, Malte F.

2017-10-01

The Earth's climate is changing due to the existence of multiple radiative forcing agents. It is under question whether different forcing agents perturb the global climate in a distinct way. Previous studies have demonstrated the existence of similar climate response patterns in response to aerosol and greenhouse gas (GHG) forcings. In this study, the sensitivity of tropospheric temperature response patterns to surface heating distributions is assessed by forcing an atmospheric general circulation model coupled to an aquaplanet slab ocean with a wide range of possible forcing patterns. We show that a common climate pattern emerges in response to localized forcing at different locations. This pattern, characterized by enhanced warming in the tropical upper troposphere and the polar lower troposphere, resembles the historical trends from observations and models as well as the future projections. Atmospheric dynamics in combination with thermodynamic air-sea coupling are primarily responsible for shaping this pattern. Identifying this common pattern strengthens our confidence in the projected response to GHG and aerosols in complex climate models.

Topological patterns of mesh textures in serpentinites

NASA Astrophysics Data System (ADS)

Miyazawa, M.; Suzuki, A.; Shimizu, H.; Okamoto, A.; Hiraoka, Y.; Obayashi, I.; Tsuji, T.; Ito, T.

2017-12-01

Serpentinization is a hydration process that forms serpentine minerals and magnetite within the oceanic lithosphere. Microfractures crosscut these minerals during the reactions, and the structures look like mesh textures. It has been known that the patterns of microfractures and the system evolutions are affected by the hydration reaction and fluid transport in fractures and within matrices. This study aims at quantifying the topological patterns of the mesh textures and understanding possible conditions of fluid transport and reaction during serpentinization in the oceanic lithosphere. Two-dimensional simulation by the distinct element method (DEM) generates fracture patterns due to serpentinization. The microfracture patterns are evaluated by persistent homology, which measures features of connected components of a topological space and encodes multi-scale topological features in the persistence diagrams. The persistence diagrams of the different mesh textures are evaluated by principal component analysis to bring out the strong patterns of persistence diagrams. This approach help extract feature values of fracture patterns from high-dimensional and complex datasets.

Earth observations taken by the Expedition 14 crew

NASA Image and Video Library

2007-03-10

ISS014-E-16597 (10 March 2007) --- Isles of Scilly, United Kingdom is featured in this image photographed by an Expedition 14 crewmember on the International Space Station. The Isles of Scilly, an archipelago of approximately 150 islands, is located some 44 kilometers southwest of the westernmost point of England (Land's End). According to scientists, the islands are an erosional remnant of an ancient granite intrusion, and are notable because they have been inhabited for over 4000 years. Historical and geological evidence cited by NASA scientists on the Isles indicates that many of the islands were larger and/or connected in the recent past--this could be due to local subsidence, rising sea levels, or a combination of both factors. Even today, it is possible to walk between certain islands during low tides. The Isles have been designated a United Kingdom Area of Outstanding Natural Beauty due to their unique landscape, ecology, and historical significance. The potential effect of rising sea level on the Isles is a primary concern for both long-term ecosystem health and human habitability. This image illustrates the geographic configuration of the archipelago, and its effect on ocean wave patterns. Long linear swells oriented northeast-southwest and moving to the southeast (from upper left to lower right) are diffracted (bent) as they approach the coastlines and small shoals of the Isles. The wave diffraction forms complex interacting surface patterns--this is most clearly visible southwest of St. Mary's island (left). The dominant ocean wave pattern resumes to the southeast of St. Mary's, but with an additional northwest-southeast oriented pattern superimposed, possibly due to winds originating in the English channel to the east (not shown). Suspended, tan-colored sediments visible within and around the archipelago are locally derived from continuing wave erosion of the granite forming the islands and remobilization of beach sands. Bright white areas in the photograph are waves breaking on shoals.

78 FR 9373 - Taking of Marine Mammals Incidental to Specified Activities; Construction at Orcas Island and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

... at an average annual rate of 10 percent between 1991 and 1996 (Jeffries et al. 1997) and is thought... diving/surfacing patterns (such as those thought to be causing beaked whale stranding due to exposure to...) and possibly avoid predators (Wilson and Dill 2002). Experiments have shown that fish can sense both...

Two unusual anatomic variations create a diagnostic dilemma in distal ulnar nerve compression.

PubMed

Kiehn, Mark W; Derrick, Allison J; Iskandar, Bermans J

2008-09-01

Diagnosis of peripheral neuropathies is based upon patterns of functional deficits and electrodiagnostic testing. However, anatomic variations can lead to confounding patterns of physical and electrodiagnostic findings. Authors present a case of ulnar nerve compression due to a rare combination of anatomic variations, aberrant branching pattern, and FCU insertion at the wrist, which posed a diagnostic and therapeutic dilemma. The literature related to isolated distal ulnar motor neuropathy and anatomic variations of the ulnar nerve and adjacent structures is also reviewed. This case demonstrates how anatomic variations can complicate the interpretation of clinical and electrodiagnostic findings and underscores the importance of thorough exploration of the nerve in consideration for possible variations. (c) 2008 Wiley-Liss, Inc.

Rapid Transfer of Abstract Rules to Novel Contexts in Human Lateral Prefrontal Cortex

PubMed Central

Cole, Michael W.; Etzel, Joset A.; Zacks, Jeffrey M.; Schneider, Walter; Braver, Todd S.

2011-01-01

Flexible, adaptive behavior is thought to rely on abstract rule representations within lateral prefrontal cortex (LPFC), yet it remains unclear how these representations provide such flexibility. We recently demonstrated that humans can learn complex novel tasks in seconds. Here we hypothesized that this impressive mental flexibility may be possible due to rapid transfer of practiced rule representations within LPFC to novel task contexts. We tested this hypothesis using functional MRI and multivariate pattern analysis, classifying LPFC activity patterns across 64 tasks. Classifiers trained to identify abstract rules based on practiced task activity patterns successfully generalized to novel tasks. This suggests humans can transfer practiced rule representations within LPFC to rapidly learn new tasks, facilitating cognitive performance in novel circumstances. PMID:22125519

Two cases of malignant hypertension with reversible diffuse leukoencephalopathy exhibiting a reversible nocturnal blood pressure "riser" pattern.

PubMed

Eguchi, Kazuo; Kasahara, Kentaro; Nagashima, Akinori; Mor, Tadashi; Nii, Takanobu; Ibaraki, Kazuo; Kario, Kazuomi; Shimada, Kazuyuki

2002-05-01

We report two cases of malignant hypertension with reversible diffuse leukoencephalopathy demonstrating a nocturnal blood pressure (BP) rising pattern ("riser" pattern). Case 1 was a 54-year-old man diagnosed with malignant hypertension who presented with diffuse leukoencephalopathy and nocturnal BP rise during the acute phase. These abnormal findings diminished after treatment of hypertension. Case 2 was a 50-year-old woman diagnosed with malignant hypertension in association with leukoencephalopathy, heart failure and acute renal failure. She also presented with a "riser" pattern during the acute phase. In contrast to case 1, the leukoencephalopathy and "riser" pattern in case 2 were not improved even after 1 month of treatment. Following intensive antihypertensive treatment, renal failure was improved in case 1, but renal failure was not improved after 1 month in case 2. In conclusion, a possible explanation of this phenomenon is that a causative volume overload due to renal dysfunction produced the temporal leukoencephalopathy-like brain edema and "riser" pattern in these cases.

Temporal trends and spatial patterns in nutrient export along the Mississippi River and its Tributaries

NASA Astrophysics Data System (ADS)

Stewart, B.; Li, L.

2017-12-01

The Mississippi River, the largest river in the U. S., exports excessive nutrients from the land to the sea, causing the problem of hypoxia in the Gulf of Mexico. In this research, we examined nutrient export along the Mississippi River and its tributaries to understand its trends and patterns and to identify the major factors contributing to these trends. We examined nutrient data from 1950 - 2017 for four sites along the Mississippi River and four tributary sites from the U. S. Geological Survey. The species included: total nitrogen, organic nitrogen, ammonia, nitrate, orthophosphate, and phosphorous. We analyzed the power law relationship of concentration and discharge, for which the export of nutrient species exhibited several trends. Both nitrogen (N) and phosphorous (P) species exhibited mostly chemodynamic behavior. This is in contrast to previous observations in smaller agricultural land where N and P export was mostly chemostatic with no significant change in concentration as discharge varies, suggesting possible scaling effects at different spatial scales. We also compared the average annual concentration over time at each site. The N concentration decreased from upstream to downstream, likely due to greater agricultural activities in the upstream Mississippi river and possible denitrification along the river. The N concentration also increased with time. The P species, however, fluctuated from site to site with no clear spatial patterns, but consistently exhibited higher concentrations at upstream sites with greater agricultural activities. The P species also fluctuated over time, likely due to patterns in discharge and agricultural activities. The results of this research can be further explored by calculating the total export of nutrients into the Gulf of Mexico to determine limits and drivers of nutrient export for better water management, thus helping prevent hypoxia and eutrophication within the Mississippi River basin.

Teleconnection between sea ice in the Barents Sea in June and the Silk Road, Pacific-Japan and East Asian rainfall patterns in August

NASA Astrophysics Data System (ADS)

He, Shengping; Gao, Yongqi; Furevik, Tore; Wang, Huijun; Li, Fei

2018-01-01

In contrast to previous studies that have tended to focus on the influence of the total Arctic sea-ice cover on the East Asian summer tripole rainfall pattern, the present study identifies the Barents Sea as the key region where the June sea-ice variability exerts the most significant impacts on the East Asian August tripole rainfall pattern, and explores the teleconnection mechanisms involved. The results reveal that a reduction in June sea ice excites anomalous upward air motion due to strong near-surface thermal forcing, which further triggers a meridional overturning wave-like pattern extending to midlatitudes. Anomalous downward motion therefore forms over the Caspian Sea, which in turn induces zonally oriented overturning circulation along the subtropical jet stream, exhibiting the east-west Rossby wave train known as the Silk Road pattern. It is suggested that the Bonin high, a subtropical anticyclone predominant near South Korea, shows a significant anomaly due to the eastward extension of the Silk Road pattern to East Asia. As a possible descending branch of the Hadley cell, the Bonin high anomaly ultimately triggers a meridional overturning, establishing the Pacific-Japan pattern. This in turn induces an anomalous anticyclone and cyclone pair over East Asia, and a tripole vertical convection anomaly meridionally oriented over East Asia. Consequently, a tripole rainfall anomaly pattern is observed over East Asia. Results from numerical experiments using version 5 of the Community Atmosphere Model support the interpretation of this chain of events.

Teleconnection between Sea Ice in the Barents Sea in June and the Silk Road, Pacific-Japan and East Asian Rainfall Patterns in August

NASA Astrophysics Data System (ADS)

He, S.; Gao, Y.; Furevik, T.; Huijun, W.; Li, F.

2017-12-01

In contrast to previous studies that have tended to focus on the influence of the total Arctic sea-ice cover on the East Asian summer tripole rainfall pattern, the present study identifies the Barents Sea as the key region where the June sea-ice variability exerts the most significant impacts on the East Asian August tripole rainfall pattern, and explores the teleconnection mechanisms involved. The results reveal that a reduction in June sea ice excites anomalous upward air motion due to strong near-surface thermal forcing, which further triggers a meridional overturning wave-like pattern extending to midlatitudes. Anomalous downward motion therefore forms over the Caspian Sea, which in turn induces zonally oriented overturning circulation along the subtropical jet stream, exhibiting the east-west Rossby wave train known as the Silk Road pattern. It is suggested that the Bonin high, a subtropical anticyclone predominant near South Korea, shows a significant anomaly due to the eastward extension of the Silk Road pattern to East Asia. As a possible descending branch of the Hadley cell, the Bonin high anomaly ultimately triggers a meridional overturning, establishing the Pacific-Japan pattern. This in turn induces an anomalous anticyclone and cyclone pair over East Asia, and a tripole vertical convection anomaly meridionally oriented over East Asia. Consequently, a tripole rainfall anomaly pattern is observed over East Asia. Results from numerical experiments using version 5 of the Community Atmosphere Model support the interpretation of this chain of events.

Printed batteries and conductive patterns in technical textiles

NASA Astrophysics Data System (ADS)

Willert, Andreas; Meuser, Carmen; Baumann, Reinhard R.

2018-05-01

Various applications of functional devices need a tailored and reliable supply of electrical energy. Batteries are electrochemical systems that deliver energy for functional devices and applications. Due to the common use, several rigid types of batteries have been standardized. To fully integrate the battery into a product that is bendable, free in geometry and less than 1 mm thick, printing of power adaptable batteries is a challenging area of research. Therefore, the well-known zinc-manganese system, which is very promising due to its environmental sustainability and its simplicity, has been used to manufacture battery solutions on a new kind of substrate: technical textiles. Another challenge is the deposition of conductive patterns. At present, embroidery with metallic yarn is the only possibility to provide conducting paths on technical textiles, a time-consuming and elaborate process. Screen printed conductive pathways will generate a new momentum in the manufacturing of conductivity on textiles.

[Hormonal and inflammatory impact of different dietetic composition: emphasis on dietary patterns and specific dietary factors].

PubMed

Bressan, Josefina; Hermsdorff, Helen H M; Zulet, María Angeles; Martínez, José Alfredo

2009-07-01

Healthy dietary pattern, characterized by the consumption of fruits, vegetables, white meats, skim dairy products, nuts and moderate intake of vegetable oils and alcohol, is an important factor for a lower risk of chronic disease such as obesity, metabolic syndrome and cardiovascular disease. This beneficial effect can be explained, at least partially, by its modulating role on biomarkers of insulin sensitivity and atherosclerosis as well as of inflammation and endothelial function. On the other hand, the intake of specific dietary factors, such as unsaturated fatty acids (oleic and alpha-linolenic) and micronutrients with antioxidant properties (vitamins A, E and C; selenium, zinc) has been discussed, due to its potential protector action due to chronic disease occurrence and its possible profits in hormonal, metabolic and inflammatory regulations that these dietetic factors can provide within a nutritional treatment to obesity and metabolic syndrome.

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

PubMed Central

Pandey, Shivendra; Gultepe, Evin; Gracias, David H.

2013-01-01

There are numerous techniques such as photolithography, electron-beam lithography and soft-lithography that can be used to precisely pattern two dimensional (2D) structures. These technologies are mature, offer high precision and many of them can be implemented in a high-throughput manner. We leverage the advantages of planar lithography and combine them with self-folding methods1-20 wherein physical forces derived from surface tension or residual stress, are used to curve or fold planar structures into three dimensional (3D) structures. In doing so, we make it possible to mass produce precisely patterned static and reconfigurable particles that are challenging to synthesize. In this paper, we detail visualized experimental protocols to create patterned particles, notably, (a) permanently bonded, hollow, polyhedra that self-assemble and self-seal due to the minimization of surface energy of liquefied hinges21-23 and (b) grippers that self-fold due to residual stress powered hinges24,25. The specific protocol described can be used to create particles with overall sizes ranging from the micrometer to the centimeter length scales. Further, arbitrary patterns can be defined on the surfaces of the particles of importance in colloidal science, electronics, optics and medicine. More generally, the concept of self-assembling mechanically rigid particles with self-sealing hinges is applicable, with some process modifications, to the creation of particles at even smaller, 100 nm length scales22, 26 and with a range of materials including metals21, semiconductors9 and polymers27. With respect to residual stress powered actuation of reconfigurable grasping devices, our specific protocol utilizes chromium hinges of relevance to devices with sizes ranging from 100 μm to 2.5 mm. However, more generally, the concept of such tether-free residual stress powered actuation can be used with alternate high-stress materials such as heteroepitaxially deposited semiconductor films5,7 to possibly create even smaller nanoscale grasping devices. PMID:23407436

Quantum Mechanics, Pattern Recognition, and the Mammalian Brain

NASA Astrophysics Data System (ADS)

Chapline, George

2008-10-01

Although the usual way of representing Markov processes is time asymmetric, there is a way of describing Markov processes, due to Schrodinger, which is time symmetric. This observation provides a link between quantum mechanics and the layered Bayesian networks that are often used in automated pattern recognition systems. In particular, there is a striking formal similarity between quantum mechanics and a particular type of Bayesian network, the Helmholtz machine, which provides a plausible model for how the mammalian brain recognizes important environmental situations. One interesting aspect of this relationship is that the "wake-sleep" algorithm for training a Helmholtz machine is very similar to the problem of finding the potential for the multi-channel Schrodinger equation. As a practical application of this insight it may be possible to use inverse scattering techniques to study the relationship between human brain wave patterns, pattern recognition, and learning. We also comment on whether there is a relationship between quantum measurements and consciousness.

A core-halo pattern of entropy creation in gravitational collapse

NASA Astrophysics Data System (ADS)

Wren, Andrew J.

2018-03-01

This paper presents a kinetic theory model of gravitational collapse due to a small perturbation. Solving the relevant equations yields a pattern of entropy destruction in a spherical core around the perturbation, and entropy creation in a surrounding halo. This indicates collisional "de-relaxation" in the core, and collisional relaxation in the halo. Core-halo patterns are ubiquitous in the astrophysics of gravitational collapse, and are found here without any of the prior assumptions of such a pattern usually made in analytical models. Motivated by this analysis, the paper outlines a possible scheme for identifying structure formation in a set of observations or a simulation. This scheme involves a choice of coarse-graining scale appropriate to the structure under consideration, and might aid exploration of hierarchical structure formation, supplementing the usual density-based methods for highlighting astrophysical and cosmological structure at various scales.

A core-halo pattern of entropy creation in gravitational collapse

NASA Astrophysics Data System (ADS)

Wren, Andrew J.

2018-07-01

This paper presents a kinetic theory model of gravitational collapse due to a small perturbation. Solving the relevant equations yields a pattern of entropy destruction in a spherical core around the perturbation, and entropy creation in a surrounding halo. This indicates collisional `de-relaxation' in the core, and collisional relaxation in the halo. Core-halo patterns are ubiquitous in the astrophysics of gravitational collapse and are found here without any of the prior assumptions of such a pattern usually made in analytical models. Motivated by this analysis, the paper outlines a possible scheme for identifying structure formation in a set of observations or a simulation. This scheme involves a choice of coarse-graining scale appropriate to the structure under consideration, and might aid exploration of hierarchical structure formation, supplementing the usual density-based methods for highlighting astrophysical and cosmological structure at various scales.

Rain rate intensity model for communication link design across the Indian region

NASA Astrophysics Data System (ADS)

Kilaru, Aravind; Kotamraju, Sarat K.; Avlonitis, Nicholas; Sri Kavya, K. Ch.

2016-07-01

A study on rain statistical parameters such as one minute rain intensity, possible number of minute occurrences with respective percentage of time in a year has been evaluated for the purpose of communication link design at Ka, Q, V bands as well as at Free-Space Optical communication links (FSO). To understand possible outage period of a communication links due to rainfall and to investigate rainfall pattern, Automatic Weather Station (AWS) rainfall data is analysed due its ample presence across India. The climates of the examined AWS regions vary from desert to cold climate, heavy rainfall to variable rainfall regions, cyclone effective regions, mountain and coastal regions. In this way a complete and unbiased picture of the rainfall statistics for Indian region is evaluated. The analysed AWS data gives insight into yearly accumulated rainfall, maximum hourly accumulated rainfall, mean hourly accumulated rainfall, number of rainy days and number of rainy hours from 668 AWS locations. Using probability density function the one minute rainfall measurements at KL University is integrated with AWS measurements for estimating number of rain occurrences in terms of one minute rain intensity for annual rainfall accumulated between 100 mm and 5000 mm to give an insight into possible one minute accumulation pattern in an hour for comprehensive analysis of rainfall influence on a communication link for design engineers. So that low availability communications links at higher frequencies can be transformed into a reliable and economically feasible communication links for implementing High Throughput Services (HTS).

Graphene transport mediated by micropatterned substrates

NASA Astrophysics Data System (ADS)

Hinnefeld, J. Henry; Gill, Stephen T.; Mason, Nadya

2018-04-01

Engineered substrates offer a promising avenue towards graphene devices having tunable properties. In particular, topographically patterned substrates can expose unique behavior due to their ability to induce local variations in strain and electrostatic doping. However, to explore the range of possible science and applications, it is important to create topographic substrates that both have tunable features and are suitable for transport measurements. In this letter, we describe the fabrication of tunable, topographically patterned substrates suitable for transport measurements. We report both optical and transport measurements of graphene devices fabricated on these substrates and demonstrate the characteristic strain and local doping behavior induced by the topographic features.

Assessment of head injury of children due to golf ball impact.

PubMed

Lee, Heow Pueh; Wang, Fang

2010-10-01

Head trauma injury due to impact by a flying golf ball is one of the most severe possible injury accidents on the golf course. Numerical simulations based on the finite element method are presented to investigate head injury in children due to impact by a flying golf ball. The stress and energy flow patterns in a head model during the golf ball impact are computed for various combinations of striking speed, falling angle of the golf ball before impact, and impact location. It is found that a child is more prone to head injury due to golf ball impact on the frontal and side/temporal areas. The simulated results are found to conform to the clinical reports on children's head injuries from flying golf balls.

Direct laser interference patterning of metallic sleeves for roll-to-roll hot embossing

NASA Astrophysics Data System (ADS)

Lang, Valentin; Rank, Andreas; Lasagni, Andrés. F.

2017-03-01

Surfaces equipped with periodic patterns with feature sizes in the micrometer, submicrometer and nanometer range present outstanding surface properties. Many of these surfaces can be found on different plants and animals. However, there are few methods capable to produce such patterns in a one-step process on relevant technological materials. Direct laser interference patterning (DLIP) provides both high resolution as well as high throughput. Recently, fabrication rates up to 1 m2·min-1 could be achieved. However, resolution was limited to a few micrometers due to typical thermal effects that arise when nanosecond pulsed laser systems are used. Therefore, this study introduces an alternative to ns-DLIP for the fabrication of multi-scaled micrometer and submicrometer structures on nickel surfaces using picosecond pulses (10 ps at a wavelength of 1064 nm). Due to the nature of the interaction process of the metallic surfaces with the ultrashort laser pulses, it was not only possible to directly transfer the shape of the interference pattern intensity distribution to the material (with spatial periods ranging from 1.5 μm to 5.7 μm), but also to selectively obtain laser induce periodic surface structures with feature sizes in the submicrometer and nanometer range. Finally, the structured nickel sleeves are utilized in a roll-to-roll hot embossing unit for structuring of polymer foils. Processing speeds up to 25 m·min-1 are reported.

Auxiliary drying to prevent pattern collapse in high aspect ratio nanostructures

NASA Astrophysics Data System (ADS)

Liu, Gang; Zhou, Jie; Xiong, Ying; Zhang, Xiaobo; Tian, Yangchao

2011-07-01

Many defects are generated in densely packed high aspect ratio structures during nanofabrication. Pattern collapse is one of the serious problems that may arise, mainly due to the capillary force during drying after the rinsing process. In this paper, a method of auxiliary drying is presented to prevent pattern collapse in high aspect ratio nanostructures by adding an auxiliary substrate as a reinforcing rib to restrict deformation and to balance the capillary force. The principle of the method is presented based on the analysis of pattern collapse. A finite element method is then applied to analyze the deformation of the resist beams caused by the surface tension using the ANSYS software, and the effect of the nanostructure's length to width ratio simulated and analyzed. Finally, the possible range of applications based on the proposed method is discussed. Our results show that the aspect ratio may be increased 2.6 times without pattern collapse; furthermore, this method can be widely used in the removal of solvents in micro- and nanofabrication.

Auxiliary drying to prevent pattern collapse in high aspect ratio nanostructures.

PubMed

Liu, Gang; Zhou, Jie; Xiong, Ying; Zhang, Xiaobo; Tian, Yangchao

2011-07-29

Many defects are generated in densely packed high aspect ratio structures during nanofabrication. Pattern collapse is one of the serious problems that may arise, mainly due to the capillary force during drying after the rinsing process. In this paper, a method of auxiliary drying is presented to prevent pattern collapse in high aspect ratio nanostructures by adding an auxiliary substrate as a reinforcing rib to restrict deformation and to balance the capillary force. The principle of the method is presented based on the analysis of pattern collapse. A finite element method is then applied to analyze the deformation of the resist beams caused by the surface tension using the ANSYS software, and the effect of the nanostructure's length to width ratio simulated and analyzed. Finally, the possible range of applications based on the proposed method is discussed. Our results show that the aspect ratio may be increased 2.6 times without pattern collapse; furthermore, this method can be widely used in the removal of solvents in micro- and nanofabrication.

Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies.

PubMed

Lopez, Maria-Cecilia; Ungaro, Ricardo F; Baker, Henry V; Moldawer, Lyle L; Robertson, Alison; Abbott, Margaret; Roberts, Sparkle M; Grattan, Lynn M; Morris, J Glenn

2016-07-01

Ciguatera fish poisoning (ciguatera) is a common clinical syndrome in areas where there is dependence on tropical reef fish for food. A subset of patients develops recurrent and, in some instances, chronic symptoms, which may result in substantial disability. To identify possible biomarkers for recurrent/chronic disease, and to explore correlations with immune gene expression, peripheral blood leukocyte gene expression in 10 ciguatera patients (7 recurrent, 3 acute) from the U.S. Virgin Islands, and 5 unexposed Florida controls were evaluated. Significant differences in gene expression were noted when comparing ciguatera patients and controls; however, it was not possible to differentiate between patients with acute and recurrent disease, possibly due to the small sample sizes involved.

Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies

PubMed Central

Lopez, Maria-Cecilia; Ungaro, Ricardo F.; Baker, Henry V.; Moldawer, Lyle L.; Robertson, Alison; Abbott, Margaret; Roberts, Sparkle M.; Grattan, Lynn M.; Morris, J. Glenn

2016-01-01

Ciguatera fish poisoning (ciguatera) is a common clinical syndrome in areas where there is dependence on tropical reef fish for food. A subset of patients develops recurrent and, in some instances, chronic symptoms, which may result in substantial disability. To identify possible biomarkers for recurrent/chronic disease, and to explore correlations with immune gene expression, peripheral blood leukocyte gene expression in 10 ciguatera patients (7 recurrent, 3 acute) from the U.S. Virgin Islands, and 5 unexposed Florida controls were evaluated. Significant differences in gene expression were noted when comparing ciguatera patients and controls; however, it was not possible to differentiate between patients with acute and recurrent disease, possibly due to the small sample sizes involved. PMID:27594814

Causes of skill in seasonal predictions of the Arctic Oscillation

NASA Astrophysics Data System (ADS)

Kumar, Arun; Chen, Mingyue

2017-11-01

Based on an analysis of hindcasts from a seasonal forecast system, complemented by the analysis of a large ensemble of AMIP simulations, possible causes for skillful prediction of the winter Arctic Oscillation (AO) on a seasonal time-scale are analyzed. The possibility that the recent increase in AO skill could be due to model improvements, or due to changes in the persistence characteristics of the AO, is first discounted. The analysis then focuses on exploring the possibility that the recent increase in prediction skill in AO may be due to sampling variations or could have physical causes. Temporal variations in AO skill due entirely to sampling alone cannot be discounted as this is a fundamental constraint on verifications over a short time-series. This notion is supported from theoretical considerations, and from the analysis of the temporal variations in the perfect model skill where substantial variations in skill due to sampling alone are documented. As for the physical causes, the analysis indicates possible links in the prediction skill of AO with the SST forcing from the tropics, particularly related to the SST variations associated with the Trans-Niño Index (TNI). Interannual and low frequency variations in the TNI could have contributed to similar temporal variations in AO skill. For example, a dominance of central Pacific El Niño events after 2000 (a reflection of low-frequency variations in TNI) coincided with an increase in the prediction skill of AO. The analysis approach and results provide an avenue for further investigations; for example, model simulations forced with the SST pattern associated with the TNI, to establish or reaffirm causes for AO skill.

Bit patterned media with composite structure for microwave assisted magnetic recording

NASA Astrophysics Data System (ADS)

Eibagi, Nasim

Patterned magnetic nano-structures are under extensive research due to their interesting emergent physics and promising applications in high-density magnetic data storage, through magnetic logic to bio-magnetic functionality. Bit-patterned media is an example of such structures which is a leading candidate to reach magnetic densities which cannot be achieved by conventional magnetic media. Patterned arrays of complex heterostructures such as exchange-coupled composites are studied in this thesis as a potential for next generation of magnetic recording media. Exchange-coupled composites have shown new functionality and performance advantages in magnetic recording and bit patterned media provide unique capability to implement such architectures. Due to unique resonant properties of such structures, their possible application in spin transfer torque memory and microwave assisted switching is also studied. This dissertation is divided into seven chapters. The first chapter covers the history of magnetic recording, the need to increase magnetic storage density, and the challenges in the field. The second chapter introduces basic concepts of magnetism. The third chapter explains the fabrication methods for thin films and various lithographic techniques that were used to pattern the devices under study for this thesis. The fourth chapter introduces the exchanged coupled system with the structure of [Co/Pd] / Fe / [Co/Pd], where the thickness of Fe is varied, and presents the magnetic properties of such structures using conventional magnetometers. The fifth chapter goes beyond what is learned in the fourth chapter and utilizes polarized neutron reflectometry to study the vertical exchange coupling and reversal mechanism in patterned structures with such structure. The sixth chapter explores the dynamic properties of the patterned samples, and their reversal mechanism under microwave field. The final chapter summarizes the results and describes the prospects for future applications of these structures.

[Hereditary ectopia lentis].

PubMed

Neuhann, T M

2015-03-01

If not due to trauma, ectopia lentis is usually caused genetically. It is a main symptom of several syndromal disorders such as Marfan syndrome or homocystinuria. Also other connective tissue disorders convey an elevated risk for ectopia lentis. Isolated ectopia lentis is frequently caused by genetic alterations as well, most commonly due to mutations in ADAMTSL4. Depending on the molecular basis, the consequences for the management of patients may differ significantly: On the one hand, possible accompanying symptoms may require a specific surveillance and treatment. Also, the risk for other family members to develop ectopia lentis or accompanying symptoms can only be determined if the genetic cause and thus inheritance pattern are known. This review describes the different types and genetic causes of syndromal and isolated ectopia lentis as well as possible consequences for the patients; also it presents a sensible algorithm for the molecular diagnostic approach. Georg Thieme Verlag KG Stuttgart · New York.

Thermosolutal Marangoni convection short-time regimes - Proposals for drop tower experiments and real time computer simulation

NASA Astrophysics Data System (ADS)

Polezhaev, V. I.; Ermakov, M. K.

1992-12-01

Results are presented of a parametrical study of flow patterns, heat transfer, and time scales of thermosolutal Marangoni convection in a cavity with temperature and solutal gradients along the free surface and adiabatic bottom for the case of zero gravity. Nusselt number, concentration difference across the cavity, and flow/temperature fields for the different regimes are presented; they show the possibility to use Drop Tower 'Bremen' for measuring the developed secondary flow and heat/mass transfer due to thermosolutal Marangoni convection as well as the possibility to analyze and plan the drop tower for such experiments using the COMGA PC-based system.

California nearshore processes - ERTS 1. [coastal currents and sediments

NASA Technical Reports Server (NTRS)

Steller, D. D.; Pirie, D. M.

1974-01-01

The detectability of many nearshore processes from ERTS is made possible due to the suspended sediment present in the coastal waters. From viewing and analyzing the California coastal imagery collected during the last year and a half, the overall current patterns and their changes have become evident. It is now possible to map monthly and seasonal changes that occur throughout the year. The original objectives of detecting currents, sediment transport, estuaries and river discharge have now been expanded to include the use of ERTS information in operational problems of the U.S. Army Corps of Engineers. This incorporates the detected nearshore features into planning and organizing shore protection facilities.

Complexity of possibly gapped histogram and analysis of histogram.

PubMed

Fushing, Hsieh; Roy, Tania

2018-02-01

We demonstrate that gaps and distributional patterns embedded within real-valued measurements are inseparable biological and mechanistic information contents of the system. Such patterns are discovered through data-driven possibly gapped histogram, which further leads to the geometry-based analysis of histogram (ANOHT). Constructing a possibly gapped histogram is a complex problem of statistical mechanics due to the ensemble of candidate histograms being captured by a two-layer Ising model. This construction is also a distinctive problem of Information Theory from the perspective of data compression via uniformity. By defining a Hamiltonian (or energy) as a sum of total coding lengths of boundaries and total decoding errors within bins, this issue of computing the minimum energy macroscopic states is surprisingly resolved by applying the hierarchical clustering algorithm. Thus, a possibly gapped histogram corresponds to a macro-state. And then the first phase of ANOHT is developed for simultaneous comparison of multiple treatments, while the second phase of ANOHT is developed based on classical empirical process theory for a tree-geometry that can check the authenticity of branches of the treatment tree. The well-known Iris data are used to illustrate our technical developments. Also, a large baseball pitching dataset and a heavily right-censored divorce data are analysed to showcase the existential gaps and utilities of ANOHT.

Complexity of possibly gapped histogram and analysis of histogram

PubMed Central

Roy, Tania

2018-01-01

We demonstrate that gaps and distributional patterns embedded within real-valued measurements are inseparable biological and mechanistic information contents of the system. Such patterns are discovered through data-driven possibly gapped histogram, which further leads to the geometry-based analysis of histogram (ANOHT). Constructing a possibly gapped histogram is a complex problem of statistical mechanics due to the ensemble of candidate histograms being captured by a two-layer Ising model. This construction is also a distinctive problem of Information Theory from the perspective of data compression via uniformity. By defining a Hamiltonian (or energy) as a sum of total coding lengths of boundaries and total decoding errors within bins, this issue of computing the minimum energy macroscopic states is surprisingly resolved by applying the hierarchical clustering algorithm. Thus, a possibly gapped histogram corresponds to a macro-state. And then the first phase of ANOHT is developed for simultaneous comparison of multiple treatments, while the second phase of ANOHT is developed based on classical empirical process theory for a tree-geometry that can check the authenticity of branches of the treatment tree. The well-known Iris data are used to illustrate our technical developments. Also, a large baseball pitching dataset and a heavily right-censored divorce data are analysed to showcase the existential gaps and utilities of ANOHT. PMID:29515829

Complexity of possibly gapped histogram and analysis of histogram

NASA Astrophysics Data System (ADS)

Fushing, Hsieh; Roy, Tania

2018-02-01

We demonstrate that gaps and distributional patterns embedded within real-valued measurements are inseparable biological and mechanistic information contents of the system. Such patterns are discovered through data-driven possibly gapped histogram, which further leads to the geometry-based analysis of histogram (ANOHT). Constructing a possibly gapped histogram is a complex problem of statistical mechanics due to the ensemble of candidate histograms being captured by a two-layer Ising model. This construction is also a distinctive problem of Information Theory from the perspective of data compression via uniformity. By defining a Hamiltonian (or energy) as a sum of total coding lengths of boundaries and total decoding errors within bins, this issue of computing the minimum energy macroscopic states is surprisingly resolved by applying the hierarchical clustering algorithm. Thus, a possibly gapped histogram corresponds to a macro-state. And then the first phase of ANOHT is developed for simultaneous comparison of multiple treatments, while the second phase of ANOHT is developed based on classical empirical process theory for a tree-geometry that can check the authenticity of branches of the treatment tree. The well-known Iris data are used to illustrate our technical developments. Also, a large baseball pitching dataset and a heavily right-censored divorce data are analysed to showcase the existential gaps and utilities of ANOHT.

Electrochemical deposition onto self-assembled monolayers: new insights into micro- and nanofabrication.

PubMed

Schilardi, Patricia L; Dip, Patricio; dos Santos Claro, Paula C; Benítez, Guillermo A; Fonticelli, Mariano H; Azzaroni, Omar; Salvarezza, Roberto C

2005-12-16

Pattern transfer with high resolution is a frontier topic in the emerging field of nanotechnologies. Electrochemical molding is a possible route for nanopatterning metal, alloys and oxide surfaces with high resolution in a simple and inexpensive way. This method involves electrodeposition onto a conducting master covered by a self-assembled alkanethiolate monolayer (SAMs). This molecular film enables direct surface-relief pattern transfer from the conducting master to the inner face of the electrodeposit, and also allows an easy release of the electrodeposited film due their excellent anti-adherent properties. Replicas of the original conductive master can be also obtained by a simple two-step procedure. SAM quality and stability under electrodeposition conditions combined with the formation of smooth electrodeposits are crucial to obtain high-quality pattern transfer with sub-50 nm resolution.

Cosmic strings and the microwave sky. I - Anisotropy from moving strings

NASA Technical Reports Server (NTRS)

Stebbins, Albert

1988-01-01

A method is developed for calculating the component of the microwave anisotropy around cosmic string loops due to their rapidly changing gravitational fields. The method is only valid for impact parameters from the string much smaller than the horizon size at the time the photon passes the string. The method makes it possible to calculate the temperature pattern around arbitrary string configurations numerically in terms of one-dimensional integrals. This method is applied to temperature jump across a string, confirming and extending previous work. It is also applied to cusps and kinks on strings, and to determining the temperature pattern far from a strong loop. The temperature pattern around a few loop configurations is explicitly calculated. Comparisons with the work of Brandenberger et al. (1986) indicates that they have overestimated the MBR anisotropy from gravitational radiation emitted from loops.

Hierarchical opal grating films prepared by slide coating of colloidal dispersions in binary liquid media.

PubMed

Lee, Wonmok; Kim, Seulgi; Kim, Seulki; Kim, Jin-Ho; Lee, Hyunjung

2015-02-15

There are active researches on well ordered opal films due to their possible applications to various photonic devices. A recently developed slide coating method is capable of rapid fabrication of large area opal films from aqueous colloidal dispersion. In the current study, the slide coating of polystyrene colloidal dispersions in water/i-propanol (IPA) binary media is investigated. Under high IPA content in a dispersing medium, resulting opal film showed a deterioration of long range order, as well as a decreased film thickness due to dilution effect. From the binary liquid, the dried opal films exhibited the unprecedented topological groove patterns with varying periodic distances as a function of alcohol contents in the media. The groove patterns were consisted of the hierarchical structures of the terraced opal layers with periodic thickness variations. The origin of the groove patterns was attributed to a shear-induced periodic instability of colloidal concentration within a thin channel during the coating process which was directly converted to a groove patterns in a resulting opal film due to rapid evaporation of liquid. The groove periods of opal films were in the range of 50-500 μm, and the thickness differences between peak and valley of the groove were significantly large enough to be optically distinguishable, such that the coated films can be utilized as the optical grating film to disperse infra-red light. Utilizing a lowered hydrophilicity of water/IPA dispersant, an opal film could be successfully coated on a flexible Mylar film without significant dewetting problem. Copyright © 2014 Elsevier Inc. All rights reserved.

Health professionals' migration in emerging market economies: patterns, causes and possible solutions.

PubMed

Nair, Manisha; Webster, Premila

2013-03-01

About a third of the countries affected by shortage of human resources for health are the emerging market economies (EMEs). The greatest shortage in absolute terms was found to be in India and Indonesia leading to health system crisis. This review identifies the patterns of migration of health workers, causes and possible solutions in these EMEs. A qualitative synthesis approach based on the 'critical review' and 'realist review' approaches to the literature review was used. The patterns of migration of health professionals' in the EMEs have led to two types of discrepancies between health needs and healthcare workers: (i) within country (rural-urban, public-private or government healthcare sector-private sector) and (ii) across countries (south to north). Factors that influence migration include lack of employment opportunities, appropriate work environment and wages in EMEs, growing demand in high-income countries due to demographic transition, favourable country policies for financial remittances by migrant workers and medical education system of EMEs. A range of successful national and international initiatives to address health workforce migration were identified. Measures to control migration should be country specific and designed in accordance with the push and pull factors existing in the EMEs.

The anisotropic signal of topotaxy during phase transitions in D″

NASA Astrophysics Data System (ADS)

Walker, Andrew M.; Dobson, David P.; Wookey, James; Nowacki, Andy; Forte, Alessandro M.

2018-03-01

While observations and modelling of seismic anisotropy in the lowermost mantle offers the possibility of imaging mantle flow close to the core-mantle boundary, current models do not explain all observations. Here, we seek to explain a long-wavelength pattern of shear wave anisotropy observed in anisotropic tomography where vertically polarised shear waves travel faster than horizontally polarised shear waves in the central Pacific and under Africa but this pattern is reversed elsewhere. In particular, we test an explanation derived from experiments on analogues, which suggest that texture may be inherited during phase transitions between bridgmanite (perovskite structured MgSiO3) and post-perovskite, and that such texture inheritance may yield the long-wavelength pattern of anisotropy. We find that models that include this effect correlate better with tomographic models than those that assume deformation due to a single phase in the lowermost mantle, supporting the idea that texture inheritance is an important factor in understanding lowermost mantle anisotropy. It is possible that anisotropy could be used to map the post-perovskite stability field in the lowermost mantle, and thus place constraints on the temperature structure above the core-mantle boundary.

Combining Population Structure with Historic Abitoic Processes to Better Understand Species and Community Range Shifts in Response to Climate Change

NASA Astrophysics Data System (ADS)

Graham, N. M.

2015-12-01

The evolution and speciation of plants is directly tied to the environment as the constrained stages of dispersal creates strong genetic differentiation among populations. This can result in differing genetic patterns between nuclear and chloroplast loci, where genes are inherited differently and dispersed via separate vectors. By developing distribution models based on genetic patterns found within a species, it is possible to begin understanding the influence of historic geomorphic and/or climatic processes on population evolution. If genetic patterns of the current range correlate with specific patterns of climate variability within the Pleistocene, it is possible that future shifts in species distribution in response to climate change can be more accurately modelled due to the historic signature that is found within inherited genes. Preliminary genetic analyses of Linanthus dichotomus, an annual herb distributed across California, suggests that the current taxonomic treatment does not accurately depict how this species is evolving. Genetic patterns of chloroplast genes suggest that populations are more correlated with biogeography than what the current nomenclature states. Additionally, chloroplast and nuclear genes show discrepancies in the dispersal across the landscape, suggesting pollinator driven gene flow overcoming seed dispersal boundaries. By comparing discrepancies between pollinator and seed induced gene flow we may be able to gain insight into historical pollinator communities within the Pleistocene. This information can then be applied to projected climate models to more accurately understand how species and/or communities will respond to a changing environment.

Preliminary study on 2 colour patterns in Ochlerotatus caspius (Pallas, 1771) (Diptera, Culicidae).

PubMed

Toma, Luciano; Severini, Francesco; Romi, Roberto; Di Luca, Marco

2016-08-30

Ochlerotatus caspius is a mosquito of medical and veterinary relevance both for its synanthropy and for its potential role in transmission of viruses and nematodes in the areas that it inhabits. Due to its wide range and the marked variability in the adult colour pattern, some authors have recognized Ochlerotatus caspius as a complex of species. In this study, we purposed to evaluate the possible taxonomic heterogeneity between 2 chromatic forms by using both morphological and molecular approaches. The preliminary results based on the identity of the rRNA internal transcribed spacer 2 (ITS-2) lead us to believe the 2 forms as a single species with a chromatic polymorphism.

Network Catastrophe: Self-Organized Patterns Reveal both the Instability and the Structure of Complex Networks

PubMed Central

Moon, Hankyu; Lu, Tsai-Ching

2015-01-01

Critical events in society or biological systems can be understood as large-scale self-emergent phenomena due to deteriorating stability. We often observe peculiar patterns preceding these events, posing a question of—how to interpret the self-organized patterns to know more about the imminent crisis. We start with a very general description — of interacting population giving rise to large-scale emergent behaviors that constitute critical events. Then we pose a key question: is there a quantifiable relation between the network of interactions and the emergent patterns? Our investigation leads to a fundamental understanding to: 1. Detect the system's transition based on the principal mode of the pattern dynamics; 2. Identify its evolving structure based on the observed patterns. The main finding of this study is that while the pattern is distorted by the network of interactions, its principal mode is invariant to the distortion even when the network constantly evolves. Our analysis on real-world markets show common self-organized behavior near the critical transitions, such as housing market collapse and stock market crashes, thus detection of critical events before they are in full effect is possible. PMID:25822423

Network Catastrophe: Self-Organized Patterns Reveal both the Instability and the Structure of Complex Networks

NASA Astrophysics Data System (ADS)

Moon, Hankyu; Lu, Tsai-Ching

2015-03-01

Critical events in society or biological systems can be understood as large-scale self-emergent phenomena due to deteriorating stability. We often observe peculiar patterns preceding these events, posing a question of--how to interpret the self-organized patterns to know more about the imminent crisis. We start with a very general description -- of interacting population giving rise to large-scale emergent behaviors that constitute critical events. Then we pose a key question: is there a quantifiable relation between the network of interactions and the emergent patterns? Our investigation leads to a fundamental understanding to: 1. Detect the system's transition based on the principal mode of the pattern dynamics; 2. Identify its evolving structure based on the observed patterns. The main finding of this study is that while the pattern is distorted by the network of interactions, its principal mode is invariant to the distortion even when the network constantly evolves. Our analysis on real-world markets show common self-organized behavior near the critical transitions, such as housing market collapse and stock market crashes, thus detection of critical events before they are in full effect is possible.

Ionospheric convection during the magnetic storm of 20-21 March 1991

NASA Technical Reports Server (NTRS)

Taylor, J. R.; Yeoman, T. K.; Lester, M.; Buonsanto, M. J.; Scali, J. L.; Ruohoniemi, J. M.; Kelly, J. D.

1994-01-01

We report on the response of high-latitude ionospheric convection during the magnetic storm of March 20-21 1990. IMP-8 measurements of solar wind plasma and interplanetary magnetic field (IMF), ionospheric convection flow measurements from the Wick and Goose Bay coherent radars, EISCAT, Millstone Hill and Sondrestorm incoherent radars and three digisondes at Millstone Hill, Goose Bay and Qaanaaq are presented. Two intervals of particular interest have been indentified. The first starts with a storm sudden commencement at 2243 UT on March 20 and includes the ionospheric activity in the following 7 h. The response time of the ionospheric convection to the southward tuning of the IMF in the dusk to midnight local times is found to be approximately half that measured in a similar study at comparable local times during more normal solar wind conditions. A subsequent reconfiguration of the nightside convection pattern was also observed, although it was not possible to distinguish between effects due to possible changes in B(sub y) and effects due to substorm activity. The second interval, 1200-2100 UT 21 March 1990, included a southward turning of the IMF which resulted in the B(sub z) component becoming -10 nT. The response time on the dayside to this change in the IMF at the magnetopause was approximately 15 min to 30 min which is a factor of approximately 2 greater than those previously measured at higher latitudes. A movement of the nightside flow reversal, possibly driven by current systems associated with the substorm expansion phases, was observed, implying that the nightside convection pattern can be dominated by substorm activity.

SCIL nanoimprint solutions: high-volume soft NIL for wafer scale sub-10nm resolution

NASA Astrophysics Data System (ADS)

Voorkamp, R.; Verschuuren, M. A.; van Brakel, R.

2016-10-01

Nano-patterning materials and surfaces can add unique functionalities and properties which cannot be obtained in bulk or micro-structured materials. Examples range from hetro-epitaxy of semiconductor nano-wires to guiding cell expression and growth on medical implants. [1] Due to the cost and throughput requirements conventional nano-patterning techniques such as deep UV lithography (cost and flat substrate demands) and electron-beam lithography (cost, throughput) are not an option. Self-assembly techniques are being considered for IC manufacturing, but require nano-sized guiding patterns, which have to be fabricated in any case.[2] Additionally, the self-assembly process is highly sensitive to the environment and layer thickness, which is difficult to control on non-flat surfaces such as PV silicon wafers or III/V substrates. Laser interference lithography can achieve wafer scale periodic patterns, but is limited by the throughput due to intensity of the laser at the pinhole and only regular patterns are possible where the pattern fill fraction cannot be chosen freely due to the interference condition.[3] Nanoimprint lithography (NIL) is a promising technology for the cost effective fabrication of sub-micron and nano-patterns on large areas. The challenges for NIL are related to the technique being a contact method where a stamp which holds the patterns is required to be brought into intimate contact with the surface of the product. In NIL a strong distinction is made between the type of stamp used, either rigid or soft. Rigid stamps are made from patterned silicon, silica or plastic foils and are capable of sub-10nm resolution and wafer scale patterning. All these materials behave similar at the micro- to nm scale and require high pressures (5 - 50 Bar) to enable conformal contact to be made on wafer scales. Real world conditions such as substrate bow and particle contaminants complicate the use of rigid stamps for wafer scale areas, reducing stamp lifetime and yield. Soft stamps, usually based on silicone rubber, behave fundamentally different compared to rigid stamps on the macro-, micro- and nanometer level. The main limitation of traditional silicones is that they are too soft to support sub-micron features against surface tension based stamp deformation and collapse [4] and handling a soft stamp to achieve accurate feature placement on wafer scales to allow overlay alignment with sub-100nm overlay accuracy.

Investigating species co-occurrence patterns when species are detected imperfectly

USGS Publications Warehouse

MacKenzie, D.I.; Bailey, L.L.; Nichols, J.D.

2004-01-01

1. Over the last 30 years there has been a great deal of interest in investigating patterns of species co-occurrence across a number of locations, which has led to the development of numerous methods to determine whether there is evidence that a particular pattern may not have occurred by random chance. 2. A key aspect that seems to have been largely overlooked is the possibility that species may not always be detected at a location when present, which leads to 'false absences' in a species presence/absence matrix that may cause incorrect inferences to be made about co-occurrence patterns. Furthermore, many of the published methods for investigating patterns of species co-occurrence do not account for potential differences in the site characteristics that may partially (at least) explain non-random patterns (e.g. due to species having similar/different habitat preferences). 3. Here we present a statistical method for modelling co-occurrence patterns between species while accounting for imperfect detection and site characteristics. This method requires that multiple presence/absence surveys for the species be conducted over a reasonably short period of time at most sites. The method yields unbiased estimates of probabilities of occurrence, and is practical when the number of species is small (< 4). 4. To illustrate the method we consider data collected on two terrestrial salamander species, Plethodonjordani and members of the Plethodon glutinosus complex, collected in the Great Smoky Mountains National Park, USA. We find no evidence that the species do not occur independently at sites once site elevation has been allowed for, although we find some evidence of a statistical interaction between species in terms of detectability that we suggest may be due to changes in relative abundances.

Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies.

PubMed

Lopez, Maria-Cecilia; Ungaro, Ricardo F; Baker, Henry V; Moldawer, Lyle L; Robertson, Alison; Abbott, Margaret; Roberts, Sparkle M; Grattan, Lynn M; Morris, J Glenn

2016-07-01

Ciguatera fish poisoning (ciguatera) is a common clinical syndrome in areas where there is dependence on tropical reef fish for food. A subset of patients develops recurrent and, in some instances, chronic symptoms, which may result in substantial disability. To identify possible biomarkers for recurrent/chronic disease, and to explore correlations with immune gene expression, peripheral blood leukocyte gene expression in 10 ciguatera patients (7 recurrent and 3 acute) from the U.S. Virgin Islands, and 5 unexposed Florida controls were evaluated. Significant differences in gene expression were noted when comparing ciguatera patients and controls; however, it was not possible to differentiate between patients with acute and recurrent disease, possibly due to the small sample sizes involved. Copyright © 2016 Elsevier B.V. All rights reserved.

Possible oriented transition of multiple-emulsion globules with asymmetric internal structures in a microfluidic constriction

NASA Astrophysics Data System (ADS)

Wang, Jingtao; Li, Xiaoduan; Wang, Xiaoyong; Guan, Jing

2014-05-01

When a globule with a complete symmetry (such as simple spherical droplets and concentric double emulsions) is transiting in a constriction tube, there is only one pattern of the transition. However, for a multiple-emulsion globule with asymmetric internal structures, there are many possible patterns with different pressure drops Δp due to various initial orientations of the inner droplets. In this paper, a boundary integral method developed recently is employed to investigate numerically the possible oriented transition of a globule with two unequal inner droplets in an axisymmetric microfluidic constriction. The transition is driven by an axisymmetric Poiseuille flow with a fixed volume flow rate, and the rheological behaviors of the globule are observed carefully. When the big inner droplet is initially located in the front of the globule, the maximum pressure drop during the transition is always lower than that when it is initially placed in the rear. Thus, a tropism—whereby a globule more easily gets through the constriction when its bigger inner droplet locates in its front initially—might exist, in which the orientating stimulus is the required pressure drops. The physical explanation of this phenomenon has also been analyzed in this paper.

Failure modes of Y-TZP abutments with external hex implant-abutment connection determined by fractographic analysis.

PubMed

Basílio, Mariana de Almeida; Delben, Juliana Aparecida; Cesar, Paulo Francisco; Rizkalla, Amin Sami; Santos Junior, Gildo Coelho; Arioli Filho, João Neudenir

2016-07-01

Yttria-stabilized tetragonal zirconia (Y-TZP) was introduced as ceramic implant abutments due to its excellent mechanical properties. However, the damage patterns for Y-TZP abutments are limited in the literature. Fractographic analyses can provide insights as to the failure origin and related mechanisms. The purpose of this study was to analyze fractured Y-TZP abutments to establish fractographic patterns and then possible reasons for failure. Thirty two prefabricated Y-TZP abutments on external hex implants were retrieved from a single-load-to failure test according to the ISO 14801. Fractographic analyses were conducted under polarized-light estereo and scanning electro microscopy. The predominant fracture pattern was abutment fracture at the connecting region. Classic fractographic features such as arrest lines, hackle, and twist hackle established that failure started where Y-TZP abutments were in contact with the retention screw edges. The abutment screw design and the loading point were the reasons for localized stress concentration and fracture patterns. Copyright © 2016 Elsevier Ltd. All rights reserved.

Positive and negative ZnO micropatterning on functionalized polymer surfaces.

PubMed

Yang, Peng; Zou, Shengli; Yang, Wantai

2008-09-01

Patterned ZnO deposition on substrates has received increasing attention because of its great potential in photocatalysis, energy conversion, and electro-optical techniques. Chemical solution growth is especially promising for organic substrates due to its very mild reaction conditions. Here this method is used on functionality-patterned polymer surfaces in order to fabricate positive and negative ZnO micropatterns. A ZnO film made of arrayed rods, typically 500-750 nm in diameter and 2.5 microm in length, is selectively obtained on sulfated and hydroxylated regions of biaxially oriented poly(propylene), giving rise to positive patterns. For reactive polyesters such as poly(ethylene terephthalate), the ZnO rods selectively remain on the unmodified original regions, creating negative patterns. Unlike complex photolithography procedures, the irradiation and patterning processes do not require the use of positive or negative photoresists, and possible damage from acidic solutions on the underlying substrate during the chemical etching process is avoided. The process thus proves to be a simple, creditable, and low-cost method, which could be easily applied on a variety of inert and reactive polymer surfaces.

Plate Like Convection with Viscous Strain Weakening and Corresponding Surface Deformation Pattern

NASA Astrophysics Data System (ADS)

Fuchs, L.; Becker, T. W.

2017-12-01

How plate tectonic surface motions are generated by mantle convection on Earth and possibly other terrestrial type planets has recently become more readily accessible with fully dynamic convection computations. However, it remains debated how plate-like the behavior in such models truly is, and in particular how the well plate boundary dynamics are captured in models which typically exclude the effects of deformation history and memory. Here, we analyze some of the effects of viscous strain weakening on plate behavior and the interactions between interior convection dynamics and surface deformation patterns. We use the finite element code CitcomCU to model convection in a 3D Cartesian model setup. The models are internally heated, with an Arrhenius-type temperature dependent viscosity including plastic yielding and viscous strain weakening (VSW) and healing (VSWH). VSW can mimic first order features of more complex damage mechanisms such as grain-size dependent rheology. Besides plate diagnostic parameters (Plateness, Mobility, and Toroidal: Poloidal ratio) to analyze the tectonic behavior our models, we also explore how "plate boundaries" link to convective patterns. In a first model series, we analyze general surface deformation patterns without VSW. In the early stages, deformation patterns are clearly co-located with up- and downwelling limbs of convection. Along downwellings strain-rates are high and localized, whereas upwellings tend to lead to broad zones of high deformation. At a more advanced stage, however, the plates' interior is highly deformed due to continuous strain accumulation and resurfaced inherited strain. Including only VSW leads to more localized deformation along downwellings. However, at a more advanced stage plate-like convection fails due an overall weakening of the material. This is prevented including strain healing. Deformation pattern at the surface more closely coincide with the internal convection patterns. The average surface deformation is reduced significantly and mainly governed by the location of the up- and downwellings. VSWH thereby affects plate dynamics due to two main properties: the intensity of weakening with increasing strain and the strain healing rate. As both increase, mobility increases as well and strain becomes more localized at the downwellings.

Historical root of precision medicine: an ancient concept concordant with the modern pharmacotherapy.

PubMed

Moeini, Reihaneh; Memariani, Zahra; Pasalar, Parvin; Gorji, Narjes

2017-04-04

Pharmacogenomics and pharmacoproteomics are new sciences that their goal is achieving therapeutics with maximum results and minimal side effects for each individual due to the pattern of his genome and proteome.Although they considered new and high technology sciences but in distant past, Persian sages like Avicenna also knew about importance of "personalized medicine" and used specific patterns to detect individual differences in order to select suitable medication.Based on experience and analogy they divided individuals into different categories considering characteristics like body color, body temperature, sleep-awake pattern and skeletal structure.They also paid attention to effect of environmental conditions such as climate, job and the change of seasons on the influence of medication.Considering the low cost and ease of use of these experiences, it seems that researching their opinions can uncover the historical roots of modern pharmacoproteomics and can possibly infuse new ideas in this field.

On the Dynamical Regimes of Pattern-Accelerated Electroconvection.

PubMed

Davidson, Scott M; Wessling, Matthias; Mani, Ali

2016-03-03

Recent research has established that electroconvection can enhance ion transport at polarized surfaces such as membranes and electrodes where it would otherwise be limited by diffusion. The onset of such overlimiting transport can be influenced by the surface topology of the ion selective membranes as well as inhomogeneities in their electrochemical properties. However, there is little knowledge regarding the mechanisms through which these surface variations promote transport. We use high-resolution direct numerical simulations to develop a comprehensive analysis of electroconvective flows generated by geometric patterns of impermeable stripes and investigate their potential to regularize electrokinetic instabilities. Counterintuitively, we find that reducing the permeable area of an ion exchange membrane, with appropriate patterning, increases the overall ion transport rate by up to 80%. In addition, we present analysis of nonpatterned membranes, and find a novel regime of electroconvection where a multivalued current is possible due to the coexistence of multiple convective states.

Trace metals in suspended particles, sediments and Asiatic clams (Corbicula fluminea) of the Río de la Plata Estuary, Argentina.

PubMed

Bilos, C; Colombo, J C; Presa, M J

1998-01-01

Suspended particulate matter (SPM), sandy sediments and Asiatic clams were collected at seven sites along 150 km of the Río de la Plata coast to assess the magnitude of trace metal pollution in the area. Metal concentrations in SPM (Cu: 7.4-109; Cr: 75-408; Mn: 525-1341 microg(-1)), sediments (Cr: 16-27; Zn: 26-99; Mn: 221-489 microg(-1)) and bivalves (Cd: 0.5-1.9; Ni: 1.3-6.4; Cr: 1.3-11; Mn: 15-81; Cu: 28-89; Zn: 118-316 microg g(-1)) are comparable to those reported for other moderately polluted world rivers. Cu levels in Asiatic clams are among the highest, similar to those reported for heavily polluted sites. SPM Cu and Cr concentrations displayed a clear geographical trend with values increasing with proximity to major urban centers. Sediments showed a less clear pattern possibly due to their coarse nature (>98% sand) and higher proportion of mineral-associated residual metals. The clams showed a complex pattern due to the variability introduced by size-related factors and the natural dynamics of SPM in the estuary. Cr and Mn showed an apparent reverse industrial trend with higher concentrations in clams collected at distant stations near the turbidity maximum zone, possibly reflecting enhanced particle retention. Cu, Cd and Ni showed no clear geographical pattern, whereas Zn increased in the clams collected in the most industrialized area. A significant relationship with clam size was observed for Cu (positive) and Zn (negative) suggesting different physiological requirements for both metals with age. A principal component analysis confirmed these geographical and size-related trends.

A 15-year climatology of wind pattern impacts on surface ozone in Houston, Texas

NASA Astrophysics Data System (ADS)

Souri, Amir Hossein; Choi, Yunsoo; Li, Xiangshang; Kotsakis, Alexander; Jiang, Xun

2016-06-01

Houston is recognized for its large petrochemical industrial facilities providing abundant radicals for tropospheric ozone formation. Fortunately, maximum daily 8-h average (MDA8) surface ozone concentrations have declined in Houston (- 0.6 ± 0.3 ppbv yr- 1) during the summers (i.e., May to September) of 2000 to 2014, possibly due to the reductions in precursor emissions by effective control policies. However, it is also possible that changes in meteorological variables have affected ozone concentrations. This study focused on the impact of long-term wind patterns which have the highest impact on ozone in Houston. The analysis of long-term wind patterns can benefit surface ozone studies by 1) providing wind patterns that distinctly changed ozone levels, 2) investigating the frequency of patterns and the respective changes and 3) estimating ozone trends in specific wind patterns that local emissions are mostly involved, thus separating emissions impacts from meteorology to some extent. To this end, the 900-hPa flow patterns in summers of 2000 to 2014 were clustered in seven classes (C1-C7) by deploying an unsupervised partitioning method. We confirm the characteristics of the clusters from a backward trajectory analysis, monitoring networks, and a regional chemical transport model simulation. The results indicate that Houston has experienced a statistically significant downward trend (- 0.6 ± 0.4 day yr- 1) of the cluster of weak easterly and northeasterly days (C4), when the highest fraction of ozone exceedances (MDA8 > 70 ppbv) occurred. This suggests that the reduction in ozone precursors was not the sole reason for the decrease in ozone exceedance days (- 1.5 ± 0.6 day yr- 1). Further, to examine the efficiency of control policies intended to reduce the amount of ozone, we estimated the trend of MDA8 ozone in C4 and C5 (weak winds) days when local emissions are primarily responsible for high ambient ozone levels. Both C4 and C5 show a large reduction in the 95th percentile and summertime trends mainly due to effective control strategies. Based on the 5th percentile daytime ozone for C1 (strong southeasterly wind) in coastal sites, this study found that the cleanest air masses that Houston received became more polluted during the summer of 2000-2014 by 1-3 ppbv. Though this study focused on Houston, the analysis method presented could generally be used to estimate ozone trends in other regions where surface ozone is dominantly influenced by both wind patterns and local emissions.

Changes in patterns of persistent halogenated compounds through a pelagic food web in the Baltic Sea.

PubMed

Stephansen, Diana A; Svendsen, Tore C; Vorkamp, Katrin; Frier, Jens-Ole

2012-02-01

The concentrations and patterns of persistent halogenated compounds (PHCs), including polychlorinated biphenyls (PCBs), DDT, hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB) and polybrominated diphenyl ethers (PBDEs) were examined in a pelagic food web from the southern Baltic Sea consisting of sediment, zooplankton, sprat, Atlantic salmon and anadromous brown trout. Lipid-normalized concentrations generally increased from low trophic levels to high trophic levels, with the exception of HCHs. Due to high concentrations of PBDEs in some zooplankton samples, biomagnification of BDE-47 was only observed for salmon/sprat and trout/sprat. Sprat collected individually and from salmon stomach had significantly different lipid-normalized concentrations and varied in their PHC pattern as well, possibly indicating a large natural variation within the Baltic Sea. The highest lipid-normalized concentrations were found in brown trout. Salmon and brown trout were similar in their PHC pattern suggesting similar food sources. Variation in PHC patterns among trophic levels was not smaller than that among geographically distinct locations, confirming the importance of comparable trophic levels for the assessment of PHC patterns, e.g. for tracing migratory fish. Copyright © 2011 Elsevier Ltd. All rights reserved.

Parallel evolution of facial stripe patterns in the Neolamprologus brichardi/pulcher species complex endemic to Lake Tanganyika.

PubMed

Duftner, Nina; Sefc, Kristina M; Koblmüller, Stephan; Salzburger, Walter; Taborsky, Michael; Sturmbauer, Christian

2007-11-01

Colour pattern diversity can be due to random processes or to natural or sexual selection. Consequently, similarities in colour patterns are not always correlated with common ancestry, but may result from convergent evolution under shared selection pressures or drift. Neolamprologus brichardi and Neolamprologus pulcher have been described as two distinct species based on differences in the arrangement of two dark bars on the operculum. Our study uses DNA sequences of the mitochondrial control region to show that relatedness of haplotypes disagrees with species assignment based on head colour pattern. This suggests repeated parallel evolution of particular stripe patterns. The complete lack of shared haplotypes between populations of the same or different phenotypes reflects strong philopatric behaviour, possibly induced by the cooperative breeding mode in which offspring remain in their natal territory and serve as helpers until they disperse to nearby territories or take over a breeding position. Concordant phylogeographic patterns between N. brichardi/N. pulcher populations and other rock-dwelling cichlids suggest that the same colonization routes have been taken by sympatric species and that these routes were affected by lake level fluctuations in the past.

Application of urban neighborhoods in understanding of local level electricity consumption patterns

NASA Astrophysics Data System (ADS)

Roy Chowdhury, P. K.; Bhaduri, B. L.

2017-12-01

Aggregated national or regional level electricity consumption data fail to capture the spatial variation in consumption, a function of location, climate, topography, and local economics. Spatial monitoring of electricity usage patterns helps to understand derivers of location specific consumption behavior and develop models to cater to the consumer needs, plan efficiency measures, identify settled areas lacking access, and allows for future planning through assessing requirements. Developed countries have started to deploy sensor systems such as smart meters to gather information on local level consumption patterns, but such infrastructure is virtually nonexistent in developing nations, resulting in serious dearth of reliable data for planners and policy makers. Remote sensing of artificial nighttime lights from human settlements have proven useful to study electricity consumptions from global to regional scales, however, local level studies remain scarce. Using the differences in spatial characteristics among different urban neighborhoods such as industrial, commercial and residential, observable through very high resolution day time satellite images (<0.5 meter), formal urban neighborhoods have been generated through texture analysis. In this study, we explore the applicability of these urban neighborhoods in understanding local level electricity consumption patterns through exploring possible correlations between the spatial characteristics of these neighborhoods, associated general economic activities, and corresponding VIIRS day-night band (DNB) nighttime lights observations, which we use as a proxy for electricity consumption in the absence of ground level consumption data. The overall trends observed through this analysis provides useful explanations helping in understanding of broad electricity consumption patterns in urban areas lacking ground level observations. This study thus highlights possible application of remote sensing data driven methods in providing novel insights into local level socio-economic patterns that were hitherto undetected due to lack of ground data.

Patterned growth of carbon nanotubes on Si substrates without predeposition of metal catalysts

NASA Astrophysics Data System (ADS)

Chen, Y.; Yu, J.

2005-07-01

Aligned carbon nanotubes (CNTs) can be readily synthesized on quartz or silicon-oxide-coated Si substrates using a chemical vapor deposition method, but it is difficult to grow them on pure Si substrates without predeposition of metal catalysts. We report that aligned CNTs were grown by pyrolysis of iron phthalocyanine at 1000°C on the templates created on Si substrates with simple mechanical scratching. Scanning electron microscopy and x-ray energy spectroscopy analysis revealed that the trenches and patterns created on the surface of Si substrates were preferred nucleation sites for nanotube growth due to a high surface energy, metastable surface structure, and possible capillarity effect. A two-step pyrolysis process maintained Fe as an active catalyst.

Investigation of model-based physical design restrictions (Invited Paper)

NASA Astrophysics Data System (ADS)

Lucas, Kevin; Baron, Stanislas; Belledent, Jerome; Boone, Robert; Borjon, Amandine; Couderc, Christophe; Patterson, Kyle; Riviere-Cazaux, Lionel; Rody, Yves; Sundermann, Frank; Toublan, Olivier; Trouiller, Yorick; Urbani, Jean-Christophe; Wimmer, Karl

2005-05-01

As lithography and other patterning processes become more complex and more non-linear with each generation, the task of physical design rules necessarily increases in complexity also. The goal of the physical design rules is to define the boundary between the physical layout structures which will yield well from those which will not. This is essentially a rule-based pre-silicon guarantee of layout correctness. However the rapid increase in design rule requirement complexity has created logistical problems for both the design and process functions. Therefore, similar to the semiconductor industry's transition from rule-based to model-based optical proximity correction (OPC) due to increased patterning complexity, opportunities for improving physical design restrictions by implementing model-based physical design methods are evident. In this paper we analyze the possible need and applications for model-based physical design restrictions (MBPDR). We first analyze the traditional design rule evolution, development and usage methodologies for semiconductor manufacturers. Next we discuss examples of specific design rule challenges requiring new solution methods in the patterning regime of low K1 lithography and highly complex RET. We then evaluate possible working strategies for MBPDR in the process development and product design flows, including examples of recent model-based pre-silicon verification techniques. Finally we summarize with a proposed flow and key considerations for MBPDR implementation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Jaesun; Cho, Younho; Park, Jun-Pil

Guided wave was widely studied for plate and pipe due to the great application area. Guided wave has advantage on long distance inspection for an inaccessible area and apart from transducer. Quite often shrink fit structures were found in nuclear power facilities. In this paper, two pipes were designed with perfect shrink fit condition for Stainless Steel 316. The displacement distribution was calculated with boundary condition. The interface wave propagation pattern was analyzed by the numerical modeling. The experimental results show a possibility of weld delamination and defect detection.

The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling.

PubMed

O'Dea, R D; King, J R

2013-06-01

Juxtacrine signalling mechanisms are known to be crucial in tissue and organ development, leading to spatial patterns in gene expression. We investigate the patterning behaviour of a discrete model of juxtacrine cell signalling due to Owen & Sherratt (1998, Mathematical modelling of juxtacrine cell signalling. Math. Biosci., 153, 125-150) in which ligand molecules, unoccupied receptors and bound ligand-receptor complexes are modelled. Feedback between the ligand and receptor production and the level of bound receptors is incorporated. By isolating two parameters associated with the feedback strength and employing numerical simulation, linear stability and bifurcation analysis, the pattern-forming behaviour of the model is analysed under regimes corresponding to lateral inhibition and induction. Linear analysis of this model fails to capture the patterning behaviour exhibited in numerical simulations. Via bifurcation analysis, we show that since the majority of periodic patterns fold subcritically from the homogeneous steady state, a wide variety of stable patterns exists at a given parameter set, providing an explanation for this failure. The dominant pattern is isolated via numerical simulation. Additionally, by sampling patterns of non-integer wavelength on a discrete mesh, we highlight a disparity between the continuous and discrete representations of signalling mechanisms: in the continuous case, patterns of arbitrary wavelength are possible, while sampling such patterns on a discrete mesh leads to longer wavelength harmonics being selected where the wavelength is rational; in the irrational case, the resulting aperiodic patterns exhibit 'local periodicity', being constructed from distorted stable shorter wavelength patterns. This feature is consistent with experimentally observed patterns, which typically display approximate short-range periodicity with defects.

Mössbauer studies of iron hydride at high pressure

NASA Astrophysics Data System (ADS)

Choe, I.; Ingalls, R.; Brown, J. M.; Sato-Sorensen, Y.; Mills, R.

1991-07-01

We have measured in situ Mössbauer spectra of iron hydride made in a diamond anvil cell at high pressure and room temperature. The spectra show a sudden change at 3.5+/-0.5 GPa from a single hyperfine pattern to a superposition of three. The former pattern results from normal α-iron with negligible hydrogen content, and the latter from residual α-iron plus newly formed iron hydride. Between 3.5 and 10.4 GPa, the extra hydride pattern have hyperfine fields for one ranging from 276 to 263 kOe, and the other, from 317 to 309 kOe. Both have isomer shifts of about 0.4 mm/sec, and negligible quadrupole splittings. X-ray studies on quenched samples have shown that iron hydride is of double hexagonal close-packed structure, whose two nonequivalent iron sites may account for the observation of two different patterns. Even allowing for the effect of volume expansion, the observed isomer shifts for the hydride are considerably more positive than those of other metallic phases of iron. At the same time, the hyperfine fields are slightly smaller than that of α-iron. As a possible explanation, one may expect a bonding of hydrogen with iron, which would result in a small reduction of 4s electrons, possibly accompanied by a small increase of 3d electrons compared with the neutral atom in metallic iron. The difference between the hyperfine fields in the two spectra are presumably due to the different symmetry at the two iron sites.

Individuality and stability in male songs of cao vit gibbons (Nomascus nasutus) with potential to monitor population dynamics.

PubMed

Feng, Jun-Juan; Cui, Liang-Wei; Ma, Chang-Yong; Fei, Han-Lan; Fan, Peng-Fei

2014-01-01

Vocal individuality and stability has been used to conduct population surveys, monitor population dynamics, and detect dispersal patterns in avian studies. To our knowledge, it has never been used in these kinds of studies among primates. The cao vit gibbon is a critically endangered species with only one small population living in a karst forest along China-Vietnam border. Due to the difficult karst terrain, an international border, long life history, and similarity in male morphology, detailed monitoring of population dynamics and dispersal patterns are not possible using traditional observation methods. In this paper, we test individuality and stability in male songs of cao vit gibbons. We then discuss the possibility of using vocal individuality for population surveys and monitoring population dynamics and dispersal patterns. Significant individuality of vocalization was detected in all 9 males, and the correct rate of individual identification yielded by discriminant function analysis using a subset of variables was satisfactory (>90%). Vocal stability over 2-6 years was also documented in 4 males. Several characters of cao vit gibbons allowed long-term population monitoring using vocal recordings in both China and Vietnam: 1) regular loud calls, 2) strong individuality and stability in male songs, 3) stable territories, and 4) long male tenure. During the course of this research, we also observed one male replacement (confirmed by vocal analysis). This time- and labor-saving method might be the most effective way to detect dispersal patterns in this transboundary population.

The hydraulic structure of the Gole Larghe Fault Zone (Italian Southern Alps) through the seismic cycle

NASA Astrophysics Data System (ADS)

Bistacchi, A.; Mittempergher, S.; Di Toro, G.; Smith, S. A. F.; Garofalo, P. S.

2017-12-01

The 600 m-thick, strike slip Gole Larghe Fault Zone (GLFZ) experienced several hundred seismic slip events at c. 8 km depth, well-documented by numerous pseudotachylytes, was then exhumed and is now exposed in beautiful and very continuous outcrops. The fault zone was also characterized by hydrous fluid flow during the seismic cycle, demonstrated by alteration halos and precipitation of hydrothermal minerals in veins and cataclasites. We have characterized the GLFZ with > 2 km of scanlines and semi-automatic mapping of faults and fractures on several photogrammetric 3D Digital Outcrop Models (3D DOMs). This allowed us obtaining 3D Discrete Fracture Network (DFN) models, based on robust probability density functions for parameters of fault and fracture sets, and simulating the fault zone hydraulic properties. In addition, the correlation between evidences of fluid flow and the fault/fracture network parameters have been studied with a geostatistical approach, allowing generating more realistic time-varying permeability models of the fault zone. Based on this dataset, we have developed a FEM hydraulic model of the GLFZ for a period of some tens of years, covering one seismic event and a postseismic period. The higher permeability is attained in the syn- to early post-seismic period, when fractures are (re)opened by off-fault deformation, then permeability decreases in the postseismic due to fracture sealing. The flow model yields a flow pattern consistent with the observed alteration/mineralization pattern and a marked channelling of fluid flow in the inner part of the fault zone, due to permeability anisotropy related to the spatial arrangement of different fracture sets. Amongst possible seismological applications of our study, we will discuss the possibility to evaluate the coseismic fracture intensity due to off-fault damage, and the heterogeneity and evolution of mechanical parameters due to fluid-rock interaction.

Nonlinear Fluid Migration Patterns in Fractured Reservoirs due to Stress-Pressure Coupling induced Changes in Reservoir Permeabilities

NASA Astrophysics Data System (ADS)

Annewandter, R.; Geiger, S.; Main, I. G.

2011-12-01

Sustainable storage of carbon dioxide (CO2) requires a thorough understanding of injection induced pressure build-up and its effects on the storage formation's integrity, since it determines the cap rock's sealing properties as well as the total storable amount of carbon dioxide. Fractures are abundant in the subsurface and difficult to detect due to their subseismic characteristic. If present in the cap during injection, they can be primary pathways for CO2 leakage. The North Sea is considered as Europe's most important carbon dioxide storage area. However, almost all of the potential storage formations have been exposed to post-glacial lithospheric flexure, possibly causing the generation of new fracture networks in the overburden whilst rebounding. Drawing upon, fast carbon dioxide uprise can be facilitated due to opening of fractures caused by changes in the stress field over time. The overall effective permeability, and hence possible leakage rates, of a fractured storage formation is highly sensitive to the fracture aperture which itself depends on the far field and in situ stress field. For this reason, our in-house general purpose reservoir simulator Complex System Modeling Platform (CSMP++) has been expanded, which is particularly designed to simulate multiphase flow on fractured porous media. It combines finite element (FE) and finite volume (FV) methods on mixed-dimensional hybrid-element meshes. The unstructured FE-FV based scheme allows us to model complex geological structures, such as fractures, at great detail. The simulator uses a compositional model for NaCl-H2O-CO2-systems for compressible fluids for computing thermophysical properties as a function of formation pressure and temperature. A fixed stress-split sequential procedure is being used to calculate coupled fluid flow and geomechanics. Numerical proof of concept studies will be presented showing the impact of fracture opening and closure on fluid migration patterns due to coupled stress-pressure induced changes in effective permeabilities.

Velocity bias induced by flow patterns around ADCPs and associated deployment platforms

USGS Publications Warehouse

Mueller, David S.

2015-01-01

Velocity measurements near the Acoustic Doppler Current Profiler (ADCP) are important for mapping surface currents, measuring velocity and discharge in shallow streams, and providing accurate estimates of discharge in the top unmeasured portion of the water column. Improvements to ADCP performance permit measurement of velocities much closer (5 cm) to the transducer than has been possible in the past (25 cm). Velocity profiles collected by the U.S. Geological Survey (USGS) with a 1200 kHz Rio Grande Zedhead ADCP in 2002 showed a negative bias in measured velocities near the transducers. On the basis of these results, the USGS initiated a study combining field, laboratory, and numerical modeling data to assess the effect of flow patterns caused by flow around the ADCP and deployment platforms on velocities measured near the transducers. This ongoing study has shown that the negative bias observed in the field is due to the flow pattern around the ADCP. The flow pattern around an ADCP violates the basic assumption of flow homogeneity required for an accurate three-dimensional velocity solution. Results, to date (2014), have indicated velocity biases within the measurable profile, due to flow disturbance, for the TRDI 1200 kHz Rio Grande Zedhead and the SonTek RiverSurveyor M9 ADCPs. The flow speed past the ADCP, the mount and the deployment platform have also been shown to play an important role in the magnitude and extent of the velocity bias.

Numerical Modeling of Surface Deformation due to Magma Chamber Inflation/Deflation in a Heterogeneous Viscoelastic Half-space

NASA Astrophysics Data System (ADS)

Dichter, M.; Roy, M.

2015-12-01

Interpreting surface deformation patterns in terms of deeper processes in regions of active magmatism is challenging and inherently non-unique. This study focuses on interpreting the unusual sombrero-shaped pattern of surface deformation in the Altiplano Puna region of South America, which has previously been modeled as the effect of an upwelling diapir of material in the lower crust. Our goal is to investigate other possible interpretations of the surface deformation feature using a suite of viscoelastic models with varying material heterogeneity. We use the finite-element code PyLith to study surface deformation due to a buried time-varying (periodic) overpressure source, a magma body, at depth within a viscoelastic half-space. In our models, the magma-body is a penny-shaped crack, with a cylindrical region above the crack that is weak relative to the surrounding material. We initially consider a magma body within a homogeneous viscoelastic half-space to determine the effect of the free surface upon deformation above and beneath the source region. We observe a complex depth-dependent phase relationship between stress and strain for elements that fall between the ground surface and the roof of the magma body. Next, we consider a volume of weak material (faster relaxation time relative to background) that is distributed with varying geometry around the magma body. We investigate how surface deformation is governed by the spatial distribution of the weak material and its rheologic parameters. We are able to reproduce a "sombrero" pattern of surface velocities for a range of models with material heterogeneity. The wavelength of the sombrero pattern is primarily controlled by the extent of the heterogeneous region, modulated by flexural effects. Our results also suggest an "optimum overpressure forcing frequency" where the lifetime of the sombrero pattern (a transient phenomenon due to the periodic nature of the overpressure forcing) reaches a maximum. Through further research we hope to better understand how the parameter space of our forward model controls the distribution of surface deformation and eventually develop a better understanding of the observed pattern of surface deformation in the Altiplano Puna.

Rapid change of chromomeric and pairing patterns of polytene chromosome tips in D. melanogaster: migration of polytene-nonpolytene transition zone?

PubMed

Roberts, P A

1979-07-01

The high variability of chromomeric patterns in near-terminal regions of polytene chromosome arms has been explored in a number of races, strains and hybrids of Drosophila melanogaster. Traditional explanations for tip differences between strains (differential compaction of chromatin, somatic or germinal deletion) are examined and, in the light of the reported observations, rejected. The range of polytene tip variability and rates of change in wild races are greater than has been supposed: strains formerly considered to be terminally deleted appear to gain terminal bands; others, formerly considered normal, appear to have lost them. Strains with high cell-to-cell tip variability are also described. Cell-to-cell variations, as well as much of the observed rapid changes in tip appearance, are probably due to heritable differences in the location of an abrupt transition zone between polytene and nonpolytene chromatin. A quantitative relationship between the amount of certain subterminal bands present and the frequency of tip association of nonhomologous chromosomes is shown and its possible significance for chromosome is shown and its possible for chromosome pairing discussed.

Epidemiology of antibiotic and heavy metal resistance in bacteria: resistance patterns in staphylococci isolated from populations in Iraq exposed and not exposed to heavy metals or antibiotics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Groves, D.J.; Short, H.; Thewaini, A.J.

Staphylococci were isolated from rural and urban populations in Iraq, which were not known to be exposed to either heavy metals or antibiotics. The antibiotic and heavy metal resistance patterns of these strains were analyzed in both mannitol-fermenting and nonfermenting strains. Over 90% of the strains were resistant to at least one of the following antibiotics: penicillin, chloramphenicol, erythromycin, tetracycline, cephalothin, lincomycin, and methicillin. In general, mannitol-fermenting strains were resistant to penicillin and cupric ions. Mannitol-negative strains were more frequently associated with mercuric ion and tetracycline resistance. Although resistance to penicillin and tetracycline can coexist, the combination of penicillin resistancemore » and tetracycline resistance usually occurred in mannitol-negative strains. The possibility of selection of heavy metal-resistant strains due to exposure to toxic levels of methylmercury was examined. No significant increase in mercuric ion-resistant strains of staphylococci or Escherichia coli were detected in exposed populations as compared to control groups. The possible reasons for this result are discussed.« less

Estimating repetitive spatiotemporal patterns from resting-state brain activity data.

PubMed

Takeda, Yusuke; Hiroe, Nobuo; Yamashita, Okito; Sato, Masa-Aki

2016-06-01

Repetitive spatiotemporal patterns in spontaneous brain activities have been widely examined in non-human studies. These studies have reported that such patterns reflect past experiences embedded in neural circuits. In human magnetoencephalography (MEG) and electroencephalography (EEG) studies, however, spatiotemporal patterns in resting-state brain activities have not been extensively examined. This is because estimating spatiotemporal patterns from resting-state MEG/EEG data is difficult due to their unknown onsets. Here, we propose a method to estimate repetitive spatiotemporal patterns from resting-state brain activity data, including MEG/EEG. Without the information of onsets, the proposed method can estimate several spatiotemporal patterns, even if they are overlapping. We verified the performance of the method by detailed simulation tests. Furthermore, we examined whether the proposed method could estimate the visual evoked magnetic fields (VEFs) without using stimulus onset information. The proposed method successfully detected the stimulus onsets and estimated the VEFs, implying the applicability of this method to real MEG data. The proposed method was applied to resting-state functional magnetic resonance imaging (fMRI) data and MEG data. The results revealed informative spatiotemporal patterns representing consecutive brain activities that dynamically change with time. Using this method, it is possible to reveal discrete events spontaneously occurring in our brains, such as memory retrieval. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Trends in Karyotype Evolution in Astyanax (Teleostei, Characiformes, Characidae): Insights From Molecular Data

PubMed Central

Pazza, Rubens; Dergam, Jorge A.; Kavalco, Karine F.

2018-01-01

The study of patterns and evolutionary processes in neotropical fish is not always an easy task due the wide distribution of major fish groups in large and extensive river basins. Thus, it is not always possible to detect or correlate possible effects of chromosome rearrangements in the evolution of biodiversity. In the Astyanax genus, chromosome data obtained since the 1970s have shown evidence of cryptic species, karyotypic plasticity, supernumerary chromosomes, triploidies, and minor chromosomal rearrangements. In the present work, we map and discuss the main chromosomal events compatible with the molecular evolution of the genus Astyanax (Characiformes, Characidae) using mitochondrial DNA sequence data, in the search for major chromosome evolutionary trends within this taxon. PMID:29713335

Quantitative analysis of skin flap blood flow in the rat using laser Doppler velocimetry.

PubMed Central

Marks, N J

1985-01-01

Two experiments carried out on rat skin flaps are described, where microvascular flow has been measured noninvasively by a laser Doppler velocimeter. Using this technique it is possible to define the limits of an axial pattern flap in terms of microvascular flow; this was found to increase when the flap is elevated. 'Random-pattern' perfusion is defined by a fall in flow. This recovers sequentially along the flap, and at a constant rate at all sites. A differential in microvascular perfusion is thus maintained along a random-pattern flap for at least the first postoperative week. In a second experiment it is shown that there appears to be a linear relationship between the reduction in skin blood flow in a random-pattern flap and the distance from the base at which the measurements are made. It is suggested that these data support the view that the blood flow in a skin flap recovers primarily from its base rather than via peripheral neovascularization, and that this is due to vascular collaterals opening within the flap rather than to a relaxation of sympathetic tone. PMID:3156992

EBV driven natural killer cell disease of the central nervous system presenting as subacute cognitive decline.

PubMed

Brett, Francesca M; Flavin, Richard; Chen, Daphne; Loftus, Teresa; Looby, Seamus; McCarthy, Allan; de Gascun, Cillian; Jaffe, Elaine S; Nor, Nurul; Javadpour, Mohsen; McCabe, Dominick

2017-11-01

Brain biopsy in patients presenting with subacute encephalopathyis never straightforward and only undertaken when a 'treatable condition' is a realistic possibility. This 63 year old right handed, immunocompetent Caucasian woman presented with an 8 month history of rapidly progressive right-sided hearing impairment, a 4 month history of intermittent headaches, tinnitus, 'dizziness', dysphagia, nausea and vomiting, with the subsequent evolution of progressive gait ataxia and a subacute global encephalopathy. The possibility of CJD was raised. Brain biopsy was carried out. Western blot for prion protein was negative. She died 9 days later and autopsy brain examination confirmed widespread subacute infarction due to an EBV positive atypical NK/T-cell infiltrate with positivity for CD3, CD56, granzyme B, perforin and EBER with absence of CD4, CD5 and CD8 expression. Molecular studies for T-cell clonality were attempted but failed due to insufficient DNA quality. Serology was consistent with past EBV infection (EBV VCA and EBNA IgG Positive). There was no evidence of disease outside the CNS. Primary central nervous system NK/T-cell lymphoma is extremely rare. The rare reported cases all present with a discrete intracranial mass, unlike the diffuse infiltrative pattern in this case. Whilst the diffuse interstitial pattern is reminiscent of chronic active EBV infection (CAEBV) seen in other organ systems such as the liver and bone marrow, the clinical presentation and epidemiologic profile are not typical for CAEBV.

EBV driven natural killer cell disease of the central nervous system presenting as subacute cognitive decline

PubMed Central

Brett, Francesca M.; Flavin, Richard; Chen, Daphne; Loftus, Teresa; Looby, Seamus; McCarthy, Allan; de Gascun, Cillian; Jaffe, Elaine S.; Nor, Nurul; Javadpour, Mohsen; McCabe, Dominick

2017-01-01

Brain biopsy in patients presenting with subacute encephalopathyis never straightforward and only undertaken when a ‘treatable condition’ is a realistic possibility. This 63 year old right handed, immunocompetent Caucasian woman presented with an 8 month history of rapidly progressive right-sided hearing impairment, a 4 month history of intermittent headaches, tinnitus, ‘dizziness’, dysphagia, nausea and vomiting, with the subsequent evolution of progressive gait ataxia and a subacute global encephalopathy. The possibility of CJD was raised. Brain biopsy was carried out. Western blot for prion protein was negative. She died 9 days later and autopsy brain examination confirmed widespread subacute infarction due to an EBV positive atypical NK/T-cell infiltrate with positivity for CD3, CD56, granzyme B, perforin and EBER with absence of CD4, CD5 and CD8 expression. Molecular studies for T-cell clonality were attempted but failed due to insufficient DNA quality. Serology was consistent with past EBV infection (EBV VCA and EBNA IgG Positive). There was no evidence of disease outside the CNS. Primary central nervous system NK/T-cell lymphoma is extremely rare. The rare reported cases all present with a discrete intracranial mass, unlike the diffuse infiltrative pattern in this case. Whilst the diffuse interstitial pattern is reminiscent of chronic active EBV infection (CAEBV) seen in other organ systems such as the liver and bone marrow, the clinical presentation and epidemiologic profile are not typical for CAEBV. PMID:28845389

The Effects of Different Electrode Types for Obtaining Surface Machining Shape on Shape Memory Alloy Using Electrochemical Machining

NASA Astrophysics Data System (ADS)

Choi, S. G.; Kim, S. H.; Choi, W. K.; Moon, G. C.; Lee, E. S.

2017-06-01

Shape memory alloy (SMA) is important material used for the medicine and aerospace industry due to its characteristics called the shape memory effect, which involves the recovery of deformed alloy to its original state through the application of temperature or stress. Consumers in modern society demand stability in parts. Electrochemical machining is one of the methods for obtained these stabilities in parts requirements. These parts of shape memory alloy require fine patterns in some applications. In order to machine a fine pattern, the electrochemical machining method is suitable. For precision electrochemical machining using different shape electrodes, the current density should be controlled precisely. And electrode shape is required for precise electrochemical machining. It is possible to obtain precise square holes on the SMA if the insulation layer controlled the unnecessary current between electrode and workpiece. If it is adjusting the unnecessary current to obtain the desired shape, it will be a great contribution to the medical industry and the aerospace industry. It is possible to process a desired shape to the shape memory alloy by micro controlling the unnecessary current. In case of the square electrode without insulation layer, it derives inexact square holes due to the unnecessary current. The results using the insulated electrode in only side show precise square holes. The removal rate improved in case of insulated electrode than others because insulation layer concentrate the applied current to the machining zone.

rf streak camera based ultrafast relativistic electron diffraction.

PubMed

Musumeci, P; Moody, J T; Scoby, C M; Gutierrez, M S; Tran, T

2009-01-01

We theoretically and experimentally investigate the possibility of using a rf streak camera to time resolve in a single shot structural changes at the sub-100 fs time scale via relativistic electron diffraction. We experimentally tested this novel concept at the UCLA Pegasus rf photoinjector. Time-resolved diffraction patterns from thin Al foil are recorded. Averaging over 50 shots is required in order to get statistics sufficient to uncover a variation in time of the diffraction patterns. In the absence of an external pump laser, this is explained as due to the energy chirp on the beam out of the electron gun. With further improvements to the electron source, rf streak camera based ultrafast electron diffraction has the potential to yield truly single shot measurements of ultrafast processes.

["Crows' feet wrinkles" in high voltage electric accident--a sign of survival?].

PubMed

Grellner, W; Madea, B

1994-01-01

A "crowsfoot-like" pattern is considered as being a sign of vitality in fatalities due to the effects of smoke, fire or high voltage (active or reflex contraction of mimic muscles). Introducing the autopsy results of a high voltage accident (66,600 V) it is discussed, whether this phenomenon and the underlying contraction of the facial muscles could also be caused by electrical current in the agony or supravital period. It seems possible that this mechanism of direct muscle contraction anticipates a nerval indirect stimulation of muscle fibres by innervating motoneurones--active or on the basis of a polysynaptic extraneous reflex. If the electrophysiological course discussed should be right, a "crowsfoot-like" pattern in equivalent cases could be interpreted as a vital sign only with great reserve.

Magnonic crystal as a delay line for low-noise auto-oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bankowski, Elena; Meitzler, Thomas; Khymyn, Roman S., E-mail: khiminr@gmail.com

2015-09-21

It is demonstrated that a delay line based on a one-dimensional magnonic crystal used in a feedback loop of a microwave auto-oscillator can substantially reduce the phase noise figure and improve other vital performance characteristics of the auto-oscillator. The advantage is achieved due to the increase of the effective delay time in the magnonic crystal, compared to the case of an un-patterned yttrium iron garnet (YIG) film, and improvement of the power-handling characteristics due to the now possible increase of the YIG film thickness. The internal modes of a magnonic crystal caused by the periodic energy exchange between the incidentmore » and reflected spin waves play the dominant role in the described effect.« less

Advanced electric-field scanning probe lithography on molecular resist using active cantilever

NASA Astrophysics Data System (ADS)

Kaestner, Marcus; Aydogan, Cemal; Ivanov, Tzvetan; Ahmad, Ahmad; Angelov, Tihomir; Reum, Alexander; Ishchuk, Valentyn; Krivoshapkina, Yana; Hofer, Manuel; Lenk, Steve; Atanasov, Ivaylo; Holz, Mathias; Rangelow, Ivo W.

2015-07-01

The routine "on demand" fabrication of features smaller than 10 nm opens up new possibilities for the realization of many devices. Driven by the thermally actuated piezoresistive cantilever technology, we have developed a prototype of a scanning probe lithography (SPL) platform which is able to image, inspect, align, and pattern features down to the single digit nanoregime. Here, we present examples of practical applications of the previously published electric-field based current-controlled scanning probe lithography. In particular, individual patterning tests are carried out on calixarene by using our developed table-top SPL system. We have demonstrated the application of a step-and-repeat SPL method including optical as well as atomic force microscopy-based navigation and alignment. The closed-loop lithography scheme was applied to sequentially write positive and negative tone features. Due to the integrated unique combination of read-write cycling, each single feature is aligned separately with the highest precision and inspected after patterning. This routine was applied to create a pattern step by step. Finally, we have demonstrated the patterning over larger areas, over existing topography, and the practical applicability of the SPL processes for lithography down to 13-nm pitch patterns. To enhance the throughput capability variable beam diameter electric field, current-controlled SPL is briefly discussed.

Residual flow patterns and morphological changes along a macro- and meso-tidal coastline

NASA Astrophysics Data System (ADS)

Leonardi, Nicoletta; Plater, Andrew James

2017-11-01

The hydrodynamic and residual transport patterns arising from oscillating tidal motion have important consequences for the transport of sediments, and for the evolution of the shoreline, especially under macro- and meso-tidal conditions. For many locations there are significant uncertainties about residual currents and sediment transport characteristics, and their possible influence on the morphological evolution of the coastline and on the character of the bed. Herein we use the coastline of SE England as a test case to investigate possible changes in residual currents, and residual transport patterns from neap to spring tide, the reciprocal interaction between residuals and the character of the bed, and the morphological evolution of the coastline at a century timescale. We found that in the long term the morphology of the system evolves toward a dynamic equilibrium configuration characterized by smaller, and spatially constant residual transport patterns. While the spatial distribution of residual currents maintains a similar trend during both neap and spring tide, during spring tide and for large areas residual currents switch between northerly and southerly directions, and their magnitude is doubled. Residual eddies develop in regions characterized by the presence of sand bars due to the interaction of the tide with the varying topography. Residual transport patterns are also computed for various sediment fractions, and based on the hydrodynamics and sediment availability at the bottom. We found that the distribution of sediments on the bed is significantly correlated with the intensity of residuals. Finally, the majority of long-term morphological changes tend to develop or augment sand banks features, with an increase in elevation and steepening of the bank contours.

Impacts of large-scale atmospheric circulation changes in winter on black carbon transport and deposition to the Arctic

NASA Astrophysics Data System (ADS)

Pozzoli, Luca; Dobricic, Srdan; Russo, Simone; Vignati, Elisabetta

2017-10-01

Winter warming and sea-ice retreat observed in the Arctic in the last decades may be related to changes of large-scale atmospheric circulation pattern, which may impact the transport of black carbon (BC) to the Arctic and its deposition on the sea ice, with possible feedbacks on the regional and global climate forcing. In this study we developed and applied a statistical algorithm, based on the maximum likelihood estimate approach, to determine how the changes of three large-scale weather patterns associated with increasing temperatures in winter and sea-ice retreat in the Arctic impact the transport of BC to the Arctic and its deposition. We found that two atmospheric patterns together determine a decreasing winter deposition trend of BC between 1980 and 2015 in the eastern Arctic while they increase BC deposition in the western Arctic. The increasing BC trend is mainly due to a pattern characterized by a high-pressure anomaly near Scandinavia favouring the transport in the lower troposphere of BC from Europe and North Atlantic directly into to the Arctic. Another pattern with a high-pressure anomaly over the Arctic and low-pressure anomaly over the North Atlantic Ocean has a smaller impact on BC deposition but determines an increasing BC atmospheric load over the entire Arctic Ocean with increasing BC concentrations in the upper troposphere. The results show that changes in atmospheric circulation due to polar atmospheric warming and reduced winter sea ice significantly impacted BC transport and deposition. The anthropogenic emission reductions applied in the last decades were, therefore, crucial to counterbalance the most likely trend of increasing BC pollution in the Arctic.

A single scaling parameter as a first approximation to describe the rainfall pattern of a place: application on Catalonia

NASA Astrophysics Data System (ADS)

Casas-Castillo, M. Carmen; Llabrés-Brustenga, Alba; Rius, Anna; Rodríguez-Solà, Raúl; Navarro, Xavier

2018-02-01

As well as in other natural processes, it has been frequently observed that the phenomenon arising from the rainfall generation process presents fractal self-similarity of statistical type, and thus, rainfall series generally show scaling properties. Based on this fact, there is a methodology, simple scaling, which is used quite broadly to find or reproduce the intensity-duration-frequency curves of a place. In the present work, the relationship of the simple scaling parameter with the characteristic rainfall pattern of the area of study has been investigated. The calculation of this scaling parameter has been performed from 147 daily rainfall selected series covering the temporal period between 1883 and 2016 over the Catalonian territory (Spain) and its nearby surroundings, and a discussion about the relationship between the scaling parameter spatial distribution and rainfall pattern, as well as about trends of this scaling parameter over the past decades possibly due to climate change, has been presented.

Identical fracture patterns in combat vehicle blast injuries due to improvised explosive devices; a case series

PubMed Central

2012-01-01

Background In November 2008, a surgical team from the Red Cross Hospital Beverwijk, the Netherlands, was deployed in Afghanistan for three months to attend in the army hospital of Kandahar. During their stay, four incidents of armored personnel carriers encountering an improvised explosive device were assessed. In each incident, two soldiers were involved, whose injuries were strikingly similar. Case presentation The described cases comprise paired thoracic vertebral fractures, radial neck fractures, calcaneal fractures and talar fractures. Moreover, the different types of blast injury are mentioned and related to the injuries described in our series. Acknowledging the different blast mechanisms is important for understanding possible injury patterns. Conclusion From this case series, as well as the existing literature on injury patterns caused by blast injuries, it seems appropriate to pay extra attention to bodily areas that were injured in other occupants of the same vehicle. Obviously, the additional surveillance for specific injuries should be complementary to the regular trauma work-up (e.g., ATLS). PMID:23051981

UPTAKE OF STRONTIUM-85 IN NON-MALIGNANT VERTEBRAL LESIONS IN MAN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bauer, G.C.H.; Scoccianti, P.

1961-01-01

By means of external scintillation counting, it was possible to demonstrate abnormally high spinal uptake of intravenously injected Sr/sup 85/ in various diseases of the vertebral column. A total dose of 50 mu c carrier-free Sr/sup 85/ was injected 7 to 14 days before recording spinal radioactivity with a collimated scintillation detector. An abnormal activity pattern was defined as a deviation from the normal pattern of twice the standard deviation of the normal mean value. Abnormal spinal patterns were detected in vertebral fractures, ankylosing spondylitis, tuberculous spondylitis, nonspecific discitis, and in a case with a lytic lesion of unknown origin.more » The value of 14 days was found more reliable than that at 7 days since by this time Sr/sup 85/ levels in soft tissues had fallen to low values. In 1 case, erroneous results were obtained from spinal counting due to a kidney stone which produced high activity in the spinal region. (H.H.D.)« less

A New Method to Measure Temperature and Burner Pattern Factor Sensing for Active Engine Control

NASA Technical Reports Server (NTRS)

Ng, Daniel

1999-01-01

The determination of the temperatures of extended surfaces which exhibit non-uniform temperature variation is very important for a number of applications including the "Burner Pattern Factor" (BPF) of turbine engines. Exploratory work has shown that use of BPF to control engine functions can result in many benefits, among them reduction in engine weight, reduction in operating cost, increase in engine life, while attaining maximum engine efficiency. Advanced engines are expected to operate at very high temperature to achieve high efficiency. Brief exposure of engine components to higher than design temperatures due to non-uniformity in engine burner pattern can reduce engine life. The engine BPF is a measure of engine temperature uniformity. Attainment of maximum temperature uniformity and high temperatures is key to maximum efficiency and long life. A new approach to determine through the measurement of just one radiation spectrum by a multiwavelength pyrometer is possible. This paper discusses a new temperature sensing approach and its application to determine the BPF.

A comparison of enhancement techniques for footwear impressions on dark and patterned fabrics.

PubMed

Farrugia, Kevin J; Bandey, Helen; Dawson, Lorna; Daéid, Niamh Nic

2013-11-01

The use of chemical enhancement techniques on porous substrates, such as fabrics, poses several challenges predominantly due to the occurrence of background staining and diffusion as well as visualization difficulties. A range of readily available chemical and lighting techniques were utilized to enhance footwear impressions made in blood, soil, and urine on dark and patterned fabrics. Footwear impressions were all prepared at a set force using a specifically built footwear rig. In most cases, results demonstrated that fluorescent chemical techniques were required for visualization as nonfluorescent techniques provided little or no contrast with the background. Occasionally, this contrast was improved by oblique lighting. Successful results were obtained for the enhancement of footwear impressions in blood; however, the enhancement of footwear impressions in urine and soil on dark and patterned fabrics was much more limited. The results demonstrate that visualization and fluorescent enhancement on porous substrates such as fabrics is possible. © 2013 American Academy of Forensic Sciences.

Rapid Particle Patterning in Surface Deposited Micro-Droplets of Low Ionic Content via Low-Voltage Electrochemistry and Electrokinetics

PubMed Central

Sidelman, Noam; Cohen, Moshik; Kolbe, Anke; Zalevsky, Zeev; Herrman, Andreas; Richter, Shachar

2015-01-01

Electrokinetic phenomena are a powerful tool used in various scientific and technological applications for the manipulation of aqueous solutions and the chemical entities within them. However, the use of DC-induced electrokinetics in miniaturized devices is highly limited. This is mainly due to unavoidable electrochemical reactions at the electrodes, which hinder successful manipulation. Here we present experimental evidence that on-chip DC manipulation of particles between closely positioned electrodes inside micro-droplets can be successfully achieved, and at low voltages. We show that such manipulation, which is considered practically impossible, can be used to rapidly concentrate and pattern particles in 2D shapes in inter-electrode locations. We show that this is made possible in low ion content dispersions, which enable low-voltage electrokinetics and an anomalous bubble-free water electrolysis. This phenomenon can serve as a powerful tool in both microflow devices and digital microfluidics for rapid pre-concentration and particle patterning. PMID:26293477

On Predictive Understanding of Extreme Events: Pattern Recognition Approach; Prediction Algorithms; Applications to Disaster Preparedness

NASA Astrophysics Data System (ADS)

Keilis-Borok, V. I.; Soloviev, A.; Gabrielov, A.

2011-12-01

We describe a uniform approach to predicting different extreme events, also known as critical phenomena, disasters, or crises. The following types of such events are considered: strong earthquakes; economic recessions (their onset and termination); surges of unemployment; surges of crime; and electoral changes of the governing party. A uniform approach is possible due to the common feature of these events: each of them is generated by a certain hierarchical dissipative complex system. After a coarse-graining, such systems exhibit regular behavior patterns; we look among them for "premonitory patterns" that signal the approach of an extreme event. We introduce methodology, based on the optimal control theory, assisting disaster management in choosing optimal set of disaster preparedness measures undertaken in response to a prediction. Predictions with their currently realistic (limited) accuracy do allow preventing a considerable part of the damage by a hierarchy of preparedness measures. Accuracy of prediction should be known, but not necessarily high.

Design Patterns Application in the ERP Systems Improvements

NASA Astrophysics Data System (ADS)

Jovičić, Bojan; Vlajić, Siniša

Design patterns application have long been present in software engineering. The same is true for ERP systems in business software. Is it possible that ERP systems do not have a good maintenance score? We have found out that there is room for maintenance improvement and that it is possible to improve ERP systems using design patterns. We have conducted comparative analysis of ease of maintenance of the ERP systems. The results show that the average score for our questions is 64%, with most answers for ERP systems like SAP, Oracle EBS, Dynamics AX. We found that 59% of ERP system developer users are not familiar with design patterns. Based on this research, we have chosen Dynamics AX as the ERP system for examination of design patterns improvement possibilities. We used software metrics to measure improvement possibility. We found that we could increase the Conditional Complexity score 17-fold by introducing design patterns.

Laser induced Erasable Patterns in a N* Liquid Crystal on an Iron Doped Lithium Niobate (Postprint)

DTIC Science & Technology

2017-10-12

be applied selectively to erase these patterns. Thus, a promising method is reported to generate reconfigurable patterns, photonic motives , and...erase these patterns. Thus, a promising method is reported to generate reconfigurable patterns, photonic motives , and touch sensitive devices in a...release (PA): distribution unlimited. loss of the patterns inscribed. Possible motives are not limited to graphics. It should be also possible to write

Translobular uptake patterns of environmental toxicants in the rat liver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tsuda, S.; Rosenberg, A.; Nakatsugawa, T.

1988-03-01

Recent autologous blood perfusion and autoradiographic studies in this laboratory have shown that uptake of the organophosphate insecticide, parathion and its metabolite, paraoxon, by the rat liver is extremely rapid. The efficient metabolism of these organophosphorus esters during the first hepatic passage results from a favorable combination of two independent factors, i.e., the titer of biodegradation enzymes within the lobule and the mode of translobular uptake. If this scenario also applies to other chemicals, it may be possible to define their threshold doses for systemic exposure. Such a possibility has far-reaching toxicological implications, and prompted this study to explore themore » less defined of the two underlying factors, i.e., translobular uptake pattern of xenobiotics using the recently developed autologous blood recirculating liver perfusion technique. The authors have limited themselves to non-ionic chemicals to avoid complications due to active transport. Because water solubility/lipophilicity is likely to be a critical factor in the binding of xenobiotics to the blood and hepatocytes and thus in their translobular behavior, xenobiotics of varied lipophilicity were pulse-infused and their elution pattern examined in the recirculating autologous blood perfusion system. Three chemicals, i.e., 1,2- and 1,3-dichlorobenzene and 4-nitroanisole were chosen as examples of relatively water-soluble xenobiotics compared with parathion. Benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin were studied as highly lipophilic toxicants.« less

Separation of high-resolution samples of overlapping latent fingerprints using relaxation labeling

NASA Astrophysics Data System (ADS)

Qian, Kun; Schott, Maik; Schöne, Werner; Hildebrandt, Mario

2012-06-01

The analysis of latent fingerprint patterns generally requires clearly recognizable friction ridge patterns. Currently, overlapping latent fingerprints pose a major problem for traditional crime scene investigation. This is due to the fact that these fingerprints usually have very similar optical properties. Consequently, the distinction of two or more overlapping fingerprints from each other is not trivially possible. While it is possible to employ chemical imaging to separate overlapping fingerprints, the corresponding methods require sophisticated fingerprint acquisition methods and are not compatible with conventional forensic fingerprint data. A separation technique that is purely based on the local orientation of the ridge patterns of overlapping fingerprints is proposed by Chen et al. and quantitatively evaluated using off-the-shelf fingerprint matching software with mostly artificially composed overlapping fingerprint samples, which is motivated by the scarce availability of authentic test samples. The work described in this paper adapts the approach presented by Chen et al. for its application on authentic high resolution fingerprint samples acquired by a contactless measurement device based on a Chromatic White Light (CWL) sensor. An evaluation of the work is also given, with the analysis of all adapted parameters. Additionally, the separability requirement proposed by Chen et al. is also evaluated for practical feasibility. Our results show promising tendencies for the application of this approach on high-resolution data, yet the separability requirement still poses a further challenge.

Seismic anisotropy in the Hellenic subduction zone: Effects of slab segmentation and subslab mantle flow

NASA Astrophysics Data System (ADS)

Evangelidis, C. P.

2017-12-01

The segmentation and differentiation of subducting slabs have considerable effects on mantle convection and tectonics. The Hellenic subduction zone is a complex convergent margin with strong curvature and fast slab rollback. The upper mantle seismic anisotropy in the region is studied focusing at its western and eastern edges in order to explore the effects of possible slab segmentation on mantle flow and fabrics. Complementary to new SKS shear-wave splitting measurements in regions not adequately sampled so far, the source-side splitting technique is applied to constrain the depth of anisotropy and to densify measurements. In the western Hellenic arc, a trench-normal subslab anisotropy is observed near the trench. In the forearc domain, source-side and SKS measurements reveal a trench-parallel pattern. This indicates subslab trench-parallel mantle flow, associated with return flow due to the fast slab rollback. The passage from continental to oceanic subduction in the western Hellenic zone is illustrated by a forearc transitional anisotropy pattern. This indicates subslab mantle flow parallel to a NE-SW smooth ramp that possibly connects the two subducted slabs. A young tear fault initiated at the Kefalonia Transform Fault is likely not entirely developed, as this trench-parallel anisotropy pattern is observed along the entire western Hellenic subduction system, even following this horizontal offset between the two slabs. At the eastern side of the Hellenic subduction zone, subslab source-side anisotropy measurements show a general trench-normal pattern. These are associated with mantle flow through a possible ongoing tearing of the oceanic lithosphere in the area. Although the exact geometry of this slab tear is relatively unknown, SKS trench-parallel measurements imply that the tear has not reached the surface yet. Further exploration of the Hellenic subduction system is necessary; denser seismic networks should be deployed at both its edges in order to achieve a more definite image of the structure and geodynamics of this area.

Alternative community structures in a kelp-urchin community: A qualitative modeling approach

USGS Publications Warehouse

Montano-Moctezuma, G.; Li, H.W.; Rossignol, P.A.

2007-01-01

Shifts in interaction patterns within a community may result from periodic disturbances and climate. The question arises as to the extent and significance of these shifting patterns. Using a novel approach to link qualitative mathematical models and field data, namely using the inverse matrix to identify the community matrix, we reconstructed community networks from kelp forests off the Oregon Coast. We simulated all ecologically plausible interactions among community members, selected the models whose outcomes match field observations, and identified highly frequent links to characterize the community network from a particular site. We tested all possible biologically reasonable community networks through qualitative simulations, selected those that matched patterns observed in the field, and further reduced the set of possibilities by retaining those that were stable. We found that a community can be represented by a set of alternative structures, or scenarios. From 11,943,936 simulated models, 0.23% matched the field observations; moreover, only 0.006%, or 748 models, were highly reliable in their predictions and met conditions for stability. Predator-prey interactions as well as non-predatory relationships were consistently found in most of the 748 models. These highly frequent connections were useful to characterize the community network in the study site. We suggest that alternative networks provide the community with a buffer to disturbance, allowing it to continuously reorganize to adapt to a variable environment. This is possible due to the fluctuating capacities of foraging species to consume alternate resources. This suggestion is sustained by our results, which indicate that none of the models that matched field observations were fully connected. This plasticity may contribute to the persistence of these communities. We propose that qualitative simulations represent a powerful technique to raise new hypotheses concerning community dynamics and to reconstruct guidelines that may govern community patterns. ?? 2007 Elsevier B.V. All rights reserved.

Large-Scale Atmospheric Teleconnection Patterns Associated with the Interannual Variability of Heatwaves in East Asia and Its Decadal Changes

NASA Astrophysics Data System (ADS)

Choi, N.; Lee, M. I.; Lim, Y. K.; Kim, K. M.

2017-12-01

Heatwave is an extreme hot weather event which accompanies fatal damage to human health. The heatwave has a strong relationship with the large-scale atmospheric teleconnection patterns. In this study, we examine the spatial pattern of heatwave in East Asia by using the EOF analysis and the relationship between heatwave frequency and large-scale atmospheric teleconnection patterns. We also separate the time scale of heatwave frequency as the time scale longer than a decade and the interannual time scale. The long-term variation of heatwave frequency in East Asia shows a linkage with the sea surface temperature (SST) variability over the North Atlantic with a decadal time scale (a.k.a. the Atlantic Multidecadal Oscillation; AMO). On the other hands, the interannual variation of heatwave frequency is linked with the two dominant spatial patterns associated with the large-scale teleconnection patterns mimicking the Scandinavian teleconnection (SCAND-like) pattern and the circumglobal teleconnection (CGT-like) pattern, respectively. It is highlighted that the interannual variation of heatwave frequency in East Asia shows a remarkable change after mid-1990s. While the heatwave frequency was mainly associated with the CGT-like pattern before mid-1990s, the SCAND-like pattern becomes the most dominant one after mid-1990s, making the CGT-like pattern as the second. This study implies that the large-scale atmospheric teleconnection patterns play a key role in developing heatwave events in East Asia. This study further discusses possible mechanisms for the decadal change in the linkage between heatwave frequency and the large-scale teleconnection patterns in East Asia such as early melting of snow cover and/or weakening of East Asian jet stream due to global warming.

Novel microfabrication stage allowing for one-photon and multi-photon light assisted molecular immobilization and for multi-photon microscope

NASA Astrophysics Data System (ADS)

Gonçalves, Odete; Snider, Scott; Zadoyan, Ruben; Nguyen, Quoc-Thang; Vorum, Henrik; Petersen, Steffen B.; Neves-Petersen, Maria Teresa

2017-02-01

Light Assisted Molecular Immobilization (LAMI) results in spatially oriented and localized covalent coupling of biomolecules onto thiol reactive surfaces. LAMI is possible due to the conserved spatial proximity between aromatic residues and disulfide bridges in proteins. When aromatic residues are excited with UV light (275-295nm), disulphide bridges are disrupted and the formed thiol groups covalently bind to surfaces. Immobilization hereby reported is achieved in a microfabrication stage coupled to a fs-laser, through one- or multi-photon excitation. The fundamental 840nm output is tripled to 280nm and focused onto the sample, leading to one-photon excitation and molecular immobilization. The sample rests on a xyz-stage with micrometer step resolution and is illuminated according to a pattern uploaded to the software controlling the stage and the shutter. Molecules are immobilized according to such pattern, with micrometer spatial resolution. Spatial masks inserted in the light path lead to light diffraction patterns used to immobilize biomolecules with submicrometer spatial resolution. Light diffraction patterns are imaged by an inbuilt microscope. Two-photon microscopy and imaging of the fluorescent microbeads is shown. Immobilization of proteins, e.g. C-reactive protein, and of an engineered molecular beacon has been successfully achieved. The beacon was coupled to a peptide containing a disulfide bridge neighboring a tryptophan residue, being this way possible to immobilize the beacon on a surface using one-photon LAMI. This technology is being implemented in the creation of point-of-care biosensors aiming at the detection of cancer and cardiovascular disease markers.

How structure sculpts function: Unveiling the contribution of anatomical connectivity to the brain's spontaneous correlation structure

NASA Astrophysics Data System (ADS)

Bettinardi, R. G.; Deco, G.; Karlaftis, V. M.; Van Hartevelt, T. J.; Fernandes, H. M.; Kourtzi, Z.; Kringelbach, M. L.; Zamora-López, G.

2017-04-01

Intrinsic brain activity is characterized by highly organized co-activations between different regions, forming clustered spatial patterns referred to as resting-state networks. The observed co-activation patterns are sustained by the intricate fabric of millions of interconnected neurons constituting the brain's wiring diagram. However, as for other real networks, the relationship between the connectional structure and the emergent collective dynamics still evades complete understanding. Here, we show that it is possible to estimate the expected pair-wise correlations that a network tends to generate thanks to the underlying path structure. We start from the assumption that in order for two nodes to exhibit correlated activity, they must be exposed to similar input patterns from the entire network. We then acknowledge that information rarely spreads only along a unique route but rather travels along all possible paths. In real networks, the strength of local perturbations tends to decay as they propagate away from the sources, leading to a progressive attenuation of the original information content and, thus, of their influence. Accordingly, we define a novel graph measure, topological similarity, which quantifies the propensity of two nodes to dynamically correlate as a function of the resemblance of the overall influences they are expected to receive due to the underlying structure of the network. Applied to the human brain, we find that the similarity of whole-network inputs, estimated from the topology of the anatomical connectome, plays an important role in sculpting the backbone pattern of time-average correlations observed at rest.

Macromolecular powder diffraction : structure solution via molecular.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doebbler, J.; Von Dreele, R.; X-Ray Science Division

Macromolecular powder diffraction is a burgeoning technique for protein structure solution - ideally suited for cases where no suitable single crystals are available. Over the past seven years, pioneering work by Von Dreele et al. [1,2] and Margiolaki et al. [3,4] has demonstrated the viability of this approach for several protein structures. Among these initial powder studies, molecular replacement solutions of insulin and turkey lysozyme into alternate space groups were accomplished. Pressing the technique further, Margiolaki et al. [5] executed the first molecular replacement of an unknown protein structure: the SH3 domain of ponsin, using data from a multianalyzer diffractometer.more » To demonstrate that cross-species molecular replacement using image plate data is also possible, we present the solution of hen egg white lysozyme using the 60% identical human lysozyme (PDB code: 1LZ1) as the search model. Due to the high incidence of overlaps in powder patterns, especially in more complex structures, we have used extracted intensities from five data sets taken at different salt concentrations in a multi-pattern Pawley refinement. The use of image plates severely increases the overlap problem due to lower detector resolution, but radiation damage effects are minimized with shorter exposure times and the fact that the entire pattern is obtained in a single exposure. This image plate solution establishes the robustness of powder molecular replacement resulting from different data collection techniques.« less

Pattern Matching for Volcano Status Assessment: what monitoring data alone can say about Mt. Etna activity

NASA Astrophysics Data System (ADS)

Cannavo, F.; Cannata, A.; Cassisi, C.

2017-12-01

The importance of assessing the ongoing status of active volcanoes is crucial not only for exposures to the local population but due to possible presence of tephra also for airline traffic. Adequately monitoring of active volcanoes, hence, plays a key role for civil protection purposes. In last decades, in order to properly monitor possible threats, continuous measuring networks have been designed and deployed on most of potentially hazardous volcanos. Nevertheless, at the present, volcano real-time surveillance is basically delegated to one or more human experts in volcanology, who interpret data coming from different kind of monitoring networks using their experience and non-measurable information (e.g. information from the field) to infer the volcano status. In some cases, raw data are used in some models to obtain more clues on the ongoing activity. In the last decades, with the development of volcano monitoring networks, huge amount of data of different geophysical, geochemical and volcanological types have been collected and stored in large databases. Having such big data sets with many examples of volcanic activity allows us to study volcano monitoring from a machine learning perspective. Thus, exploiting opportunities offered by the abundance of volcano monitoring time-series data we can try to address the following questions: Are the monitored parameters sufficient to discriminate the volcano status? Is it possible to infer/distinguish the volcano status only from the multivariate patterns of measurements? Are all the kind of measurements in the pattern equally useful for status assessment? How accurate would be an automatic system of status inference based only on pattern recognition of data? Here we present preliminary results of the data analysis we performed on a set of data and activity covering the period 2011-2017 at Mount Etna (Italy). In the considered period, we had 52 events of lava fountaining and long periods of Strombolian activity. We consider different state-of-the-art techniques of pattern recognition to try to answer the above questions. Results are objectively evaluated by using a cross-validation approach.

Instant noodles, processed food intake, and dietary pattern are associated with atopic dermatitis in an adult population (KNHANES 2009-2011).

PubMed

Park, Sunmin; Choi, Hyun-Seok; Bae, Ji-Hyun

2016-01-01

The incidence of atopic dermatitis (AD) is continuously increasing in industrialized countries, possibly due to dietary and lifestyle changes. However, the association between processed food intake and AD has not been studied in a large adult population. We investigated the association between dietary habits and AD in 17,497 adults in the 2009-2011 Korean National Health and Nutrition Examination Survey (KNHANES). We identified 4 dietary patterns using principal components analysis of a 63-item food frequency questionnaire: the "traditional dietary pattern", rich in rice and kimchi; the "processed food pattern", with more meat, instant noodles, soda, and processed foods; the "healthy dietary pattern", high in grains, vegetables, fruits, and seaweeds; and the "drinking dietary pattern", mainly drinking coffee and alcohol. Adjusted odds ratios (ORs) for AD were calculated according to dietary patterns after adjusting for potential confounders with incorporation of sample weights for the complex sample design. The "meat and processed food" pattern was associated with a significant 1.57 fold higher OR for atopic dermatitis than the low consumption group. Further analysis revealed that the increased atopic dermatitis was most closely associated with instant noodles. In contrast, the groups with high intake of rice and kimchi exhibited lower ORs, 0.38 and 0.43 folds, compared to the low intake group. Consuming instant noodles, meat and processed foods was associated with increased prevalence of atopic dermatitis, whereas consuming rice and kimchi, and coffee was associated with decreased prevalence of atopic dermatitis.

Statistical physics and economic fluctuations: do outliers exist?

NASA Astrophysics Data System (ADS)

Stanley, H. Eugene

2003-02-01

We present an overview of recent research applying ideas of statistical physics to try to better understand puzzles regarding economic fluctuations. One of these puzzles is how to describe outliers, phenomena that lie outside of patterns of statistical regularity. We review evidence consistent with the possibility that such outliers may not exist. This possibility is supported by recent analysis by Plerou et al. of a database containing the bid, ask, and sale price of each trade of every stock. Further, the data support the picture of economic fluctuations, due to Plerou et al., in which a financial market alternates between being in an “equilibrium phase” where market behavior is split roughly equally between buying and selling, and an “out-of-equilibrium phase” where the market is mainly either buying or selling.

Natural environment analysis

NASA Technical Reports Server (NTRS)

1985-01-01

Qualitative analyses (and quantitatively to the extend possible) of the influence of terrain features on wind loading of the space shuttle while on the launch pad, or during early liftoff, are presented. Initially, the climatology and meteorology producing macroscale wind patterns and characteristics fot he Vandenburg Air Force Base (VAFB) launch site are described. Also, limited field test data are analyzed, and then the nature and characteristic of flow disturbances due to the various terrain features, both natural and man-made, are then reviewed. Following this, the magnitude of these wind loads are estimated. Finally, effects of turbulence are discussed. The study concludes that the influence of complex terrain can create significant wind loading on the vehicle. Because of the limited information, it is not possible to quantify the magnitude of these loads.

Shadowing on Apollo 12 Solar Cells and Possible Movement of the ALSEP Central Station

NASA Technical Reports Server (NTRS)

Berman, Paul A.; Williams, David R.

2014-01-01

A fortuitous arrangement of a west-facing solar cell and a bracket on the Apollo 12 ALSEP (Apollo Lunar Surface Experiments Package) has allowed us to precisely determine the relative position of the Sun near sunset relative to the Apollo 12 central station over a period of nearly 8 years. The small bracket, mounted on the central station due west of the cell, casts a shadow on the cell near sunset, decreasing the output of the cell proportional to the area of shadow covering the cell. The pattern of shadowing by the bracket gives good agreement with the known change of solar azimuth on a yearly timescale, but the pattern gradually but constantly changed from year-to-year, in a manner inconsistent with the known and changing position of the Sun.

Divergent Synthesis of Chondroitin Sulfate Disaccharides and Identification of Sulfate Motifs that Inhibit Triple Negative Breast Cancer

NASA Astrophysics Data System (ADS)

Wei Poh, Zhong; Heng Gan, Chin; Lee, Eric J.; Guo, Suxian; Yip, George W.; Lam, Yulin

2015-09-01

Glycosaminoglycans (GAGs) regulate many important physiological processes. A pertinent issue to address is whether GAGs encode important functional information via introduction of position specific sulfate groups in the GAG structure. However, procurement of pure, homogenous GAG motifs to probe the “sulfation code” is a challenging task due to isolation difficulty and structural complexity. To this end, we devised a versatile synthetic strategy to obtain all the 16 theoretically possible sulfation patterns in the chondroitin sulfate (CS) repeating unit; these include rare but potentially important sulfated motifs which have not been isolated earlier. Biological evaluation indicated that CS sulfation patterns had differing effects for different breast cancer cell types, and the greatest inhibitory effect was observed for the most aggressive, triple negative breast cancer cell line MDA-MB-231.

[Forensic aspects of gunshot suicides in Germany].

PubMed

Kunz, Sebastian Niko; Meyer, Harald J; Kraus, Sybille

2013-12-01

Suicidal gunshot wounds are a common appearance in forensic casework. The main task of the coroner lies in the detection of typical pathomorphological correlates, thus differentiating between homicide, suicide and accident. Apart from characteristic bloodstain patterns on the gun and shooting hand, the localisation of the entrance wound and the position of the weapon, additional details such as family background or medical history are important aspects of forensic investigation. An uncommon choice of weaponry and its unusual morphological manifestation often complicate the examination and reconstruction of such cases. Furthermore, due to social stigmatisation, the possibility of secondary changes by relatives at the crime scene should be considered. In addition to autopsy findings, a careful crime scene investigation and bloodstain pattern analysis, a ballistic reconstruction can be an essential tool to gain knowledge of the shooting distance and position of the gun.

Diffuse-interface approach to rotating Hele-Shaw flows.

PubMed

Chen, Ching-Yao; Huang, Yu-Sheng; Miranda, José A

2011-10-01

When two fluids of different densities move in a rotating Hele-Shaw cell, the interface between them becomes centrifugally unstable and deforms. Depending on the viscosity contrast of the system, distinct types of complex patterns arise at the fluid-fluid boundary. Deformations can also induce the emergence of interfacial singularities and topological changes such as droplet pinch-off and self-intersection. We present numerical simulations based on a diffuse-interface model for this particular two-phase displacement that capture a variety of pattern-forming behaviors. This is implemented by employing a Boussinesq Hele-Shaw-Cahn-Hilliard approach, considering the whole range of possible values for the viscosity contrast, and by including inertial effects due to the Coriolis force. The role played by these two physical contributions on the development of interface singularities is illustrated and discussed.

Data preparation and evaluation techniques for x-ray diffraction microscopy.

PubMed

Steinbrener, Jan; Nelson, Johanna; Huang, Xiaojing; Marchesini, Stefano; Shapiro, David; Turner, Joshua J; Jacobsen, Chris

2010-08-30

The post-experiment processing of X-ray Diffraction Microscopy data is often time-consuming and difficult. This is mostly due to the fact that even if a preliminary result has been reconstructed, there is no definitive answer as to whether or not a better result with more consistently retrieved phases can still be obtained. We show here that the first step in data analysis, the assembly of two-dimensional diffraction patterns from a large set of raw diffraction data, is crucial to obtaining reconstructions of highest possible consistency. We have developed software that automates this process and results in consistently accurate diffraction patterns. We have furthermore derived some criteria of validity for a tool commonly used to assess the consistency of reconstructions, the phase retrieval transfer function, and suggest a modified version that has improved utility for judging reconstruction quality.

Ultrasonic enhancement of battery diffusion.

PubMed

Hilton, R; Dornbusch, D; Branson, K; Tekeei, A; Suppes, G J

2014-03-01

It has been demonstrated that sonic energy can be harnessed to enhance convection in Galvanic cells during cyclic voltammetry; however, the practical value of this approach is limited due to the lack of open volumes for convection patterns to develop in most batteries. This study evaluates the ability of ultrasonic waves to enhance diffusion in membrane separators commonly used in sandwich-architecture batteries. Studies include the measuring of open-circuit performance curves to interpret performances in terms of reductions in concentration overpotentials. The use of a 40 kHz sonicator bath can consistently increase the voltage of the battery and reduce overpotential losses up to 30%. This work demonstrates and quantifies battery enhancement due to enhanced diffusion made possible with ultrasonic energy. Copyright © 2013 Elsevier B.V. All rights reserved.

Changes in alanine turnover rate due to nutritional and genetic obesity in the rat.

PubMed

Yebras, M; Salvadó, J; Arola, L; Remesar, X; Segués, T

1994-08-01

The changes in alanine turnover were determined in Zucker rats, which were either genetically obese (fa/fa) or rendered obese by dietary treatment (cafeteria fed). The whole body rate of alanine turnover was higher in genetically obese rats than in rats in which obesity was induced by diet (cafeteria). This is possibly due to variations in the rate of the amino acid incorporation into proteins, since the rate of whole body alanine degradation is the same for both groups. Thus, the different pattern followed by alanine turnover rate in these types of obese animals reflects the differences in the nitrogen economy of these animals, pointing to a higher alanine utilization in the genetically obese animals and a conservative management of alanine in the cafeteria-fed animals.

Microwave permeability of stripe patterned FeCoN thin film

NASA Astrophysics Data System (ADS)

Wu, Yuping; Yang, Yong; Ma, Fusheng; Zong, Baoyu; Yang, Zhihong; Ding, Jun

2017-03-01

Magnetic stripe patterns are of great importance for microwave applications owing to their highly tunable microwave permeability by adjusting the geometrical dimensions. In this work, stripe patterned FeCoN films with 160 nm thickness are fabricated by using standard UV photolithography. Their microwave permeability are investigated systematically via both experiment and micromagnetic simulation. The good agreement between experimental and simulation results suggests that stripe width is crucial for the microwave magnetic properties of the stripe pattern. It is demonstrated by simulation that with increasing stripe width from 1 to 80 μm the initial permeability shows a continuous growth from about 8-322, whiles the resonance frequency drops dramatically from 18.7 to 3.1 GHz at 4 μm gap size. Smaller gap size would result in slightly increased initial permeability due to larger magnetic volume ratio, accompanied by decreased resonance frequency because of stronger magnetostatic interaction. Moreover, the experimental investigation on stripe length effect indicates that the stripe length should be kept as long as possible to achieve uniform bulk resonance mode and high permeability value. Insufficient stripe length would result in low frequency edge mode and decayed bulk mode. This study could provide valuable guidelines on the selection of proper geometry dimensions of FeCoN stripe patterns for high frequency applications.

The interannual variation in monthly temperature over Northeast China during summer

NASA Astrophysics Data System (ADS)

Chen, Wei; Lu, Riyu

2014-05-01

The interannual variations of summer surface air temperature over Northeast China (NEC) were investigated through a month-to-month analysis from May to August. The results suggested that the warmer temperature over NEC is related to a local positive 500-hPa geopotential height anomaly for all four months. However, the teleconnection patterns of atmospheric circulation anomalies associated with the monthly surface air temperature over NEC behave as a distinguished subseasonal variation, although the local positive height anomaly is common from month to month. In May and June, the teleconnection pattern is characterized by a wave train in the upper and middle troposphere from the Indian Peninsula to NEC. This wave train is stronger in June than in May, possibly due to the positive feedback between the wave train and the South Asian rainfall anomaly in June, when the South Asian summer monsoon has been established. In July and August, however, the teleconnection pattern associated with the NEC temperature anomalies is characterized by an East Asia/Pacific (EAP) or Pacific/Japan (PJ) pattern, with the existence of precipitation anomalies over the Philippine Sea and the South China Sea. This pattern is much clearer in July corresponding to the stronger convection over the Philippine Sea compared to that in August.

Using polynomials to simplify fixed pattern noise and photometric correction of logarithmic CMOS image sensors.

PubMed

Li, Jing; Mahmoodi, Alireza; Joseph, Dileepan

2015-10-16

An important class of complementary metal-oxide-semiconductor (CMOS) image sensors are those where pixel responses are monotonic nonlinear functions of light stimuli. This class includes various logarithmic architectures, which are easily capable of wide dynamic range imaging, at video rates, but which are vulnerable to image quality issues. To minimize fixed pattern noise (FPN) and maximize photometric accuracy, pixel responses must be calibrated and corrected due to mismatch and process variation during fabrication. Unlike literature approaches, which employ circuit-based models of varying complexity, this paper introduces a novel approach based on low-degree polynomials. Although each pixel may have a highly nonlinear response, an approximately-linear FPN calibration is possible by exploiting the monotonic nature of imaging. Moreover, FPN correction requires only arithmetic, and an optimal fixed-point implementation is readily derived, subject to a user-specified number of bits per pixel. Using a monotonic spline, involving cubic polynomials, photometric calibration is also possible without a circuit-based model, and fixed-point photometric correction requires only a look-up table. The approach is experimentally validated with a logarithmic CMOS image sensor and is compared to a leading approach from the literature. The novel approach proves effective and efficient.

Antarctic Temperature Extremes from MODIS Land Surface Temperatures: New Processing Methods Reveal Data Quality Puzzles

NASA Astrophysics Data System (ADS)

Grant, G.; Gallaher, D. W.

2017-12-01

New methods for processing massive remotely sensed datasets are used to evaluate Antarctic land surface temperature (LST) extremes. Data from the MODIS/Terra sensor (Collection 6) provides a twice-daily look at Antarctic LSTs over a 17 year period, at a higher spatiotemporal resolution than past studies. Using a data condensation process that creates databases of anomalous values, our processes create statistical images of Antarctic LSTs. In general, the results find few significant trends in extremes; however, they do reveal a puzzling picture of inconsistent cloud detection and possible systemic errors, perhaps due to viewing geometry. Cloud discrimination shows a distinct jump in clear-sky detections starting in 2011, and LSTs around the South Pole exhibit a circular cooling pattern, which may also be related to cloud contamination. Possible root causes are discussed. Ongoing investigations seek to determine whether the results are a natural phenomenon or, as seems likely, the results of sensor degradation or processing artefacts. If the unusual LST patterns or cloud detection discontinuities are natural, they point to new, interesting processes on the Antarctic continent. If the data artefacts are artificial, MODIS LST users should be alerted to the potential issues.

Experimental and computational investigations on severe slugging in a catenary riser

NASA Astrophysics Data System (ADS)

Duan, Jin-long; Chen, Ke; You, Yun-xiang; Gao, Song

2017-12-01

Severe slugging can occur in a pipeline-riser system at relatively low liquid and gas flow rates during gas-oil transportation, possibly causing unexpected damage to the production facilities. Experiments with air and water are conducted in a horizontal and downward inclined pipeline followed by a catenary riser in order to investigate the mechanism and characteristics of severe slugging. A theoretical model is introduced to compare with the experiments. The results show that the formation mechanism of severe slugging in a catenary riser is different from that in a vertical riser due to the riser geometry and five flow patterns are obtained and analyzed. A gas-liquid mixture slug stage is observed at the beginning of one cycle of severe slugging, which is seldom noticed in previous studies. Based on both experiments and computations, the time period and variation of pressure amplitude of severe slugging are found closely related to the superficial gas velocity, implying that the gas velocity significantly influences the flow patterns in our experiments. Moreover, good agreements between the experimental data and the numerical results are shown in the stability curve and flow regime map, which can be a possible reference for design in an offshore oil-production system.

sEMG Signal Acquisition Strategy towards Hand FES Control.

PubMed

Toledo-Peral, Cinthya Lourdes; Gutiérrez-Martínez, Josefina; Mercado-Gutiérrez, Jorge Airy; Martín-Vignon-Whaley, Ana Isabel; Vera-Hernández, Arturo; Leija-Salas, Lorenzo

2018-01-01

Due to damage of the nervous system, patients experience impediments in their daily life: severe fatigue, tremor or impaired hand dexterity, hemiparesis, or hemiplegia. Surface electromyography (sEMG) signal analysis is used to identify motion; however, standardization of electrode placement and classification of sEMG patterns are major challenges. This paper describes a technique used to acquire sEMG signals for five hand motion patterns from six able-bodied subjects using an array of recording and stimulation electrodes placed on the forearm and its effects over functional electrical stimulation (FES) and volitional sEMG combinations, in order to eventually control a sEMG-driven FES neuroprosthesis for upper limb rehabilitation. A two-part protocol was performed. First, personalized templates to place eight sEMG bipolar channels were designed; with these data, a universal template, called forearm electrode set (FELT), was built. Second, volitional and evoked movements were recorded during FES application. 95% classification accuracy was achieved using two sessions per movement. With the FELT, it was possible to perform FES and sEMG recordings simultaneously. Also, it was possible to extract the volitional and evoked sEMG from the raw signal, which is highly important for closed-loop FES control.

Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan.

PubMed

Bilal, Erhan; Rabadan, Raul; Alexe, Gabriela; Fuku, Noriyuki; Ueno, Hitomi; Nishigaki, Yutaka; Fujita, Yasunori; Ito, Masafumi; Arai, Yasumichi; Hirose, Nobuyoshi; Ruckenstein, Andrei; Bhanot, Gyan; Tanaka, Masashi

2008-06-11

We report results from the analysis of complete mitochondrial DNA (mtDNA) sequences from 112 Japanese semi-supercentenarians (aged above 105 years) combined with previously published data from 96 patients in each of three non-disease phenotypes: centenarians (99-105 years of age), healthy non-obese males, obese young males and four disease phenotypes, diabetics with and without angiopathy, and Alzheimer's and Parkinson's disease patients. We analyze the correlation between mitochondrial polymorphisms and the longevity phenotype using two different methods. We first use an exhaustive algorithm to identify all maximal patterns of polymorphisms shared by at least five individuals and define a significance score for enrichment of the patterns in each phenotype relative to healthy normals. Our study confirms the correlations observed in a previous study showing enrichment of a hierarchy of haplogroups in the D clade for longevity. For the extreme longevity phenotype we see a single statistically significant signal: a progressive enrichment of certain "beneficial" patterns in centenarians and semi-supercentenarians in the D4a haplogroup. We then use Principal Component Spectral Analysis of the SNP-SNP Covariance Matrix to compare the measured eigenvalues to a Null distribution of eigenvalues on Gaussian datasets to determine whether the correlations in the data (due to longevity) arises from some property of the mutations themselves or whether they are due to population structure. The conclusion is that the correlations are entirely due to population structure (phylogenetic tree). We find no signal for a functional mtDNA SNP correlated with longevity. The fact that the correlations are from the population structure suggests that hitch-hiking on autosomal events is a possible explanation for the observed correlations.

Mitochondrial DNA Haplogroup D4a Is a Marker for Extreme Longevity in Japan

PubMed Central

Bilal, Erhan; Rabadan, Raul; Alexe, Gabriela; Fuku, Noriyuki; Ueno, Hitomi; Nishigaki, Yutaka; Fujita, Yasunori; Ito, Masafumi; Arai, Yasumichi; Hirose, Nobuyoshi; Ruckenstein, Andrei; Bhanot, Gyan; Tanaka, Masashi

2008-01-01

We report results from the analysis of complete mitochondrial DNA (mtDNA) sequences from 112 Japanese semi-supercentenarians (aged above 105 years) combined with previously published data from 96 patients in each of three non-disease phenotypes: centenarians (99–105 years of age), healthy non-obese males, obese young males and four disease phenotypes, diabetics with and without angiopathy, and Alzheimer's and Parkinson's disease patients. We analyze the correlation between mitochondrial polymorphisms and the longevity phenotype using two different methods. We first use an exhaustive algorithm to identify all maximal patterns of polymorphisms shared by at least five individuals and define a significance score for enrichment of the patterns in each phenotype relative to healthy normals. Our study confirms the correlations observed in a previous study showing enrichment of a hierarchy of haplogroups in the D clade for longevity. For the extreme longevity phenotype we see a single statistically significant signal: a progressive enrichment of certain “beneficial” patterns in centenarians and semi-supercentenarians in the D4a haplogroup. We then use Principal Component Spectral Analysis of the SNP-SNP Covariance Matrix to compare the measured eigenvalues to a Null distribution of eigenvalues on Gaussian datasets to determine whether the correlations in the data (due to longevity) arises from some property of the mutations themselves or whether they are due to population structure. The conclusion is that the correlations are entirely due to population structure (phylogenetic tree). We find no signal for a functional mtDNA SNP correlated with longevity. The fact that the correlations are from the population structure suggests that hitch-hiking on autosomal events is a possible explanation for the observed correlations. PMID:18545700

Hierarchically Patterned Noncovalent Functionalization of 2D Materials by Controlled Langmuir-Schaefer Conversion.

PubMed

Davis, Tyson C; Bang, Jae Jin; Brooks, Jacob T; McMillan, David G; Claridge, Shelley A

2018-01-30

Noncovalent monolayer chemistries are often used to functionalize 2D materials. Nanoscopic ligand ordering has been widely demonstrated (e.g., lying-down lamellar phases of functional alkanes); however, combining this control with micro- and macroscopic patterning for practical applications remains a significant challenge. A few reports have demonstrated that standing phase Langmuir films on water can be converted into nanoscopic lying-down molecular domains on 2D substrates (e.g., graphite), using horizontal dipping (Langmuir-Schaefer, LS, transfer). Molecular patterns are known to form at scales up to millimeters in Langmuir films, suggesting the possibility of transforming such structures into functional patterns on 2D materials. However, to our knowledge, this approach has not been investigated, and the rules governing LS conversion are not well understood. In part, this is because the conversion process is mechanistically very different from classic LS transfer of standing phases; challenges also arise due to the need to characterize structure in noncovalently adsorbed ligand layers <0.5 nm thick, at scales ranging from millimeters to nanometers. Here, we show that scanning electron microscopy enables diynoic acid lying-down phases to be imaged across this range of scales; using this structural information, we establish conditions for LS conversion to create hierarchical microscopic and nanoscopic functional patterns. Such control opens the door to tailoring noncovalent surface chemistry of 2D materials to pattern local interactions with the environment.

Habitat degradation may affect niche segregation patterns in lizards

NASA Astrophysics Data System (ADS)

Pelegrin, N.; Chani, J. M.; Echevarria, A. L.; Bucher, E. H.

2013-08-01

Lizards partition resources in three main niche dimensions: time, space and food. Activity time and microhabitat use are strongly influenced by thermal environment, and may differ between species according to thermal requirements and tolerance. As thermal characteristics are influenced by habitat structure, microhabitat use and activity of lizards can change in disturbed habitats. We compared activity and microhabitat use of two abundant lizard species of the Semi-arid Chaco of Argentina between a restored and a highly degraded Chaco forest, to determine how habitat degradation affects lizard segregation in time and space, hypothesizing that as activity and microhabitat use of lizards are related to habitat structure, activity and microhabitat use of individual species can be altered in degraded habitats, thus changing segregation patterns between them. Activity changed from an overlapped pattern in a restored forest to a segregated pattern in a degraded forest. A similar trend was observed for microhabitat use, although to a less extent. No correlation was found between air temperature and lizard activity, but lizard activity varied along the day and among sites. Contrary to what was believed, activity patterns of neotropical diurnal lizards are not fixed, but affected by multiple factors related to habitat structure and possibly to interspecific interactions. Changes in activity patterns and microhabitat use in degraded forests may have important implications when analyzing the effects of climate change on lizard species, due to synergistic effects.

Evaluation of the effect scan pattern has on the trueness and precision of six intraoral digital impression systems.

PubMed

Mennito, Anthony S; Evans, Zachary P; Lauer, Abigail W; Patel, Ravi B; Ludlow, Mark E; Renne, Walter G

2018-03-01

Clinicians have been slow to adopt digital impression technologies due possibly to perceived technique sensitivities involved in data acquisition. This research has two aims: determine whether scan pattern and sequence affects the accuracy of the three-dimensional (3D) model created from this digital impression and to compare the 5 imaging systems with regards to their scanning accuracy for sextant impressions. Six digital intraoral impression systems were used to scan a typodont sextant with optical properties similar to natural teeth. The impressions were taken using five different scan patterns and the resulting digital models were overlayed on a master digital model to determine the accuracy of each scanner performing each scan pattern. Furthermore, regardless of scan pattern, each digital impression system was evaluated for accuracy to the other systems in this same manner. No differences of significance were noted in the accuracy of 3D models created using six distinct scan patterns with one exception involving the CEREC Omnicam. Planmeca Planscan was determined to be the truest scanner while 3Shape Trios was determined to be the most precise for sextant impression making. Scan pattern does not significantly affect the accuracy of the resulting digital model for sextant scanning. Companies who make digital impression systems often recommend a scan pattern specific for their system. However, every clinical scanning scenario is different and may require a different approach. Knowing how important scan pattern is with regards to accuracy would be helpful for guiding a growing number of practitioners who are utilizing this technology. © 2018 Wiley Periodicals, Inc.

Fatal tiger attack: a case report with emphasis on typical tiger injuries characterized by partially resembling stab-like wounds.

PubMed

Pathak, Hrishikesh; Borkar, Jaydeo; Dixit, Pradeep; Dhawane, Shailendra; Shrigiriwar, Manish; Dingre, Niraj

2013-10-10

Fatalities due to attacks by tigers on humans are uncommon and are rarely described in the medico-legal literature. We herein present a forensic investigation in a unique case of a fatal tiger attack in the wild on a 35 year old female in India by an Indian Bengal tiger (Panthera tigris tigris). The attack resulted in two pairs of puncture wounds over the nape area with occult cervical spine injuries resulting from transfixing of spine due to the tiger canines; multiple puncture wounds, numerous scratches and abrasions consistent with the tiger claw injuries and injury to the right jugulocarotid vessels. This case outlines the characteristic injury pattern from such an attack along with the multiple sources of the tiger injuries. The analysis of these injuries might reveal the motivation behind the attack and the big cat species involved in the attack. A tiger injury is sometimes compared with a stab injury, as the patterned injuries due to a tiger bite are characterized by multiple penetrating, stab-like wounds. So, a special attention is paid toward establishment of the cause of death from bites by the animal teeth under unknown circumstances of trauma and to exclude the possibility of a homicide beyond reasonable doubt in such cases. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Typhoon Changes in Northwestern Pacific Region and Its Relationship to Hydrologic Variability

NASA Astrophysics Data System (ADS)

Kim, J. S.; Lee, J. H.

2017-12-01

Changes in typhoon intensity are sensitively related to the thermodynamic responses of the atmosphere and ocean to warmer temperature and increased CO2 concentrations in a changing climate. Atmospheric conditions in warmer climates are likely to promote the strengthening of typhoon activity. The pattern of typhoons in the North Pacific is constantly changing due to rising sea level, the occurrence of El Niño and La Niña, and changes in weather and climate patterns due to global warming. In particular, as typhoon genesis positions are shifted to the north compared to past typhoon, the East Asia region is exposed to possible typhoon landings and potential damage. Efforts to integrate typhoon-related information into management and planning have focused on recovery in the wake of damaging events—a reactive, hazard perspective; however, there have been insufficient efforts towards regulation and water management and for multilateral assessments of environmental impacts. Therefore, climate change adaptation and countermeasures based on a variety of hydrological changes and a clear understanding of sea surface temperature changes are needed to analyze the changes in ecological systems under the influence of typhoons at the regional and local scale. In this study, we focus on typhoon - sensitive watersheds and quantify the effects of typhoons to analyze various hydrological changes due to typhoons. The results of this study provide useful information for adapting to climate change and preparing measures.

Insights into the diurnal cycle of global Earth outgoing radiation using a numerical weather prediction model

NASA Astrophysics Data System (ADS)

Gristey, Jake J.; Chiu, J. Christine; Gurney, Robert J.; Morcrette, Cyril J.; Hill, Peter G.; Russell, Jacqueline E.; Brindley, Helen E.

2018-04-01

A globally complete, high temporal resolution and multiple-variable approach is employed to analyse the diurnal cycle of Earth's outgoing energy flows. This is made possible via the use of Met Office model output for September 2010 that is assessed alongside regional satellite observations throughout. Principal component analysis applied to the long-wave component of modelled outgoing radiation reveals dominant diurnal patterns related to land surface heating and convective cloud development, respectively explaining 68.5 and 16.0 % of the variance at the global scale. The total variance explained by these first two patterns is markedly less than previous regional estimates from observations, and this analysis suggests that around half of the difference relates to the lack of global coverage in the observations. The first pattern is strongly and simultaneously coupled to the land surface temperature diurnal variations. The second pattern is strongly coupled to the cloud water content and height diurnal variations, but lags the cloud variations by several hours. We suggest that the mechanism controlling the delay is a moistening of the upper troposphere due to the evaporation of anvil cloud. The short-wave component of modelled outgoing radiation, analysed in terms of albedo, exhibits a very dominant pattern explaining 88.4 % of the variance that is related to the angle of incoming solar radiation, and a second pattern explaining 6.7 % of the variance that is related to compensating effects from convective cloud development and marine stratocumulus cloud dissipation. Similar patterns are found in regional satellite observations, but with slightly different timings due to known model biases. The first pattern is controlled by changes in surface and cloud albedo, and Rayleigh and aerosol scattering. The second pattern is strongly coupled to the diurnal variations in both cloud water content and height in convective regions but only cloud water content in marine stratocumulus regions, with substantially shorter lag times compared with the long-wave counterpart. This indicates that the short-wave radiation response to diurnal cloud development and dissipation is more rapid, which is found to be robust in the regional satellite observations. These global, diurnal radiation patterns and their coupling with other geophysical variables demonstrate the process-level understanding that can be gained using this approach and highlight a need for global, diurnal observing systems for Earth outgoing radiation in the future.

Expression of Geochemical Controls on Water Quality in Loch Vale, Rocky Mountain National Park

NASA Astrophysics Data System (ADS)

Podzorski, H.; Navarre-Sitchler, A.; Stets, E.; Clow, D. W.

2017-12-01

Relationships between concentrations of rock weathering products and discharge provide insight into the interactions between climate and solute dynamics. This concentration-discharge (C-Q) relationship is especially interesting in high alpine regions, due to their susceptibility to changes in the timing and magnitude of snowmelt. Previous studies looking at C-Q relationships have concluded that concentrations of conservative solutes remain relatively constant as discharge varies; however, these results may be due to relatively small sample sizes, especially at higher discharge values. Using water chemistry data collected regularly by the U.S. Geological Survey from Loch Vale, a high-elevation catchment in Rocky Mountain National Park, C-Q relationships were examined to determine possible geochemical controls on stream solute concentrations. A record of over 20 years of C-Q data resulted in a pattern that shows little variation in conservative solute concentrations during base flow and larger variations in concentrations around peak discharge. This observed pattern is consistent with accumulation of solutes in pore water during base flow, which are then flushed out and diluted by snowmelt. Further evidence of this flushing out mechanism is found in patterns of hysteresis that are present in annual C-Q relationships. Before peak discharge, concentrations of weathering products are higher than after peak discharge at similar values of discharge. Based on these observations, we hypothesize that the geochemical processes controlling stream chemistry vary by season. During the winter, solute concentrations are transport-limited due to slow subsurface flushing resulting in concentrations that are effectively constant and close to equilibrium. During the spring and summer, concentrations drop sharply after peak discharge due to a combination of dilution and reaction-limited processes under conditions with faster subsurface flow and continued snowmelt. This study provides insight into seasonal geochemical controls on conservative solute concentrations that can be overlooked with small, or seasonally biased, data sets.

Change in pattern of absenteeism as a result of workplace intervention for personnel support.

PubMed

Landstad, B; Vinberg, S; Ivergård, T; Gelin, G; Ekholm, J

2001-01-15

The aim was to investigate whether a preventive intervention carried out in a predominantly female workplace, that of hospital cleaners (consisting of a group of 97 women), had any effect on patterns of absenteeism. As a background, a model for analysing complex patterns of absenteeism, including sickness absences, was also developed. A further aim was to study the interactions between different forms of absenteeism. Comparison was made with a reference group consisting of employees in the same job category who only received the customary personnel support. For individuals in the intervention group who were < 42 years of age, total absence due to sickness decreased. In a multiple regression analysis, the contribution from the intervention to the decrease was significant at the 5% level. This change was particularly obvious in those who had a previous history of high absence due to sickness. No clear relationship was shown between short-term absenteeism and the interventions applied. For those who were > 42 years, short-term absence decreased for those who had been in the same jobs for a long time. The combination of increased age and experience showed a tendency to enhance this decline in short-term absenteeism due to sickness. For those > 42 years, and who at the same time have a previous history of high absenteeism, long-term absenteeism due to sickness seemed to be increasing. Increased experience tended to reduce this increase in long-term sickness absence. This combination of different effects possibly indicated the presence of a process of selection which determined who remained in the job as opposed to those who did not. An important conclusion is that different forms of absenteeism need to be looked at in parallel, and at the same time multivariate statistical analysis needs to be carried out to determine the different interactions between the factors.

Contact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006-2011.

PubMed

Dinkloh, A; Worm, M; Geier, J; Schnuch, A; Wollenberg, A

2015-06-01

Ingredients of leave-on cosmetics and body care products may sensitize. However, not every case of cosmetic intolerance is due to contact sensitization. To describe the frequency of contact sensitization due to cosmetics in a large clinic population, and a possible particular allergen pattern. Retrospective analysis of data from the Information Network of Departments of Dermatology, 2006-2011. Of 69 487 patients tested, 'cosmetics, creams, sunscreens' was the only suspected allergen source category in 10 124 patients (14.6%). A final diagnosis 'allergic contact dermatitis' was stated in 2658 of these patients (26.3%).Compared to a control group, there were significantly more reactions to fragrance mixes I and II, balsam of Peru, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and lanolin alcohols. No special pattern of fragrance sensitization could be identified. Among the preservatives, MI was by far the leading allergen, while sensitization to other widely used compounds like parabens or phenoxyethanol was rare. True allergic reactions to cosmetic ingredients are rarer than generally assumed. Limitation of exposure to MI in leave-on cosmetics and body care products is urgently needed. © 2014 European Academy of Dermatology and Venereology.

On the determination of the origin of linear anomaly in the macrostructure of VPPA welded 2219-T87 aluminum alloy

NASA Technical Reports Server (NTRS)

Jemian, W. A.

1986-01-01

The objective was to determine the cause and significance of the weld radiograph enigma, which is a linear anomaly in the features of the X-ray film. By observing features on available radiographs and in studying published reports of similar features it was possible to conclude that there are many manifestations of the enigma, and that they are all specific features of fine structure in radiographs due to natural processes connected with welding and to specific X-ray absorption and diffraction phenomena. These processes include the thermal distribution and liquid metal flow in welding, the development of microstructure, morpohology, second phase particles and porosity due to the solidification process and to the pattern of residual stresses after the weld metal has cooled to the ambient temperature. Microdensitometer traces were made across weld radiographs of standard and enigmatic types. Similar patterns were produced by computer simulation. These show that the enigma is a relatively low contrast feature compared to real weld defects, such as undercuts or centerline cracks. The enigma can be distinguished from weld defects by these microdensitometer traces. The enigma effect on weld properties is not known but is expected to be minor.

On the determination of the origin of linear anomaly in the macrostructure of VPPA welded 2219-T87 aluminum alloy: Preliminary report

NASA Technical Reports Server (NTRS)

Jemian, W. A.

1986-01-01

The cause and significance of the weld radiograph enigma, which is a linear anomaly in the features of the X-ray film is examined. By observing features on available radiographs and in studying published reports of similar features, it was possible to conclude that there are many manifestations of the enigma, and that they are all specific features of fine structure in radiographs due to natural processes connected with welding and to specific X-ray absorption and diffraction phenomena. These processes include the thermal distribution and liquid metal flow in welding, the development of microstructure, morphology, second phase particles and porosity due to the solidification process, and to the pattern of residual stresses after the weld metal has cooled to the ambient temperature. Microdensitometer traces were made across weld radiographs of standard enigmatic types. Similar patterns were produced by computer simulation. These show that the enigma is a relatively low contrast feature compared to real weld defects, such as undercuts or centerline cracks. The enigma can be distinguished from weld defects by these microdensitometer traces. The enigma effect on weld properties is not known but is expected to be minor.

Propeller Perforator Flaps in Distal Lower Leg: Evolution and Clinical Applications

PubMed Central

2012-01-01

Simple or complex defects in the lower leg, and especially in its distal third, continue to be a challenging task for reconstructive surgeons. A variety of flaps were used in the attempt to achieve excellence in form and function. After a long evolution of the reconstructive methods, including random pattern flaps, axial pattern flaps, musculocutaneous flaps and fasciocutaneous flaps, the reappraisal of the works of Manchot and Salmon by Taylor and Palmer opened the era of perforator flaps. This era began in 1989, when Koshima and Soeda, and separately Kroll and Rosenfield described the first applications of such flaps. Perforator flaps, whether free or pedicled, gained a high popularity due to their main advantages: decreasing donor-site morbidity and improving aesthetic outcome. The use as local perforator flaps in lower leg was possible due to a better understanding of the cutaneous circulation, leg vascular anatomy, angiosome and perforasome concepts, as well as innovations in flaps design. This review will describe the evolution, anatomy, flap design, and technique of the main distally pedicled propeller perforator flaps used in the reconstruction of defects in the distal third of the lower leg and foot. PMID:22783507

Use of Bisphenol A-containing baby bottles in Cameroon and Nigeria and possible risk management and mitigation measures: community as milestone for prevention.

PubMed

Pouokam, Guy Bertrand; Ajaezi, Godwin Chukwuebuka; Mantovani, Alberto; Orisakwe, Orish Ebere; Frazzoli, Chiara

2014-05-15

The plasticizer Bisphenol A (BPA) is banned in baby bottles in many industrialized countries due to safety concerns. We provide a pilot view on the potential BPA exposure of bottle-fed children in sub-Saharan Africa through an enquiry on availability, accessibility and affordability of plastic baby bottles, usage pattern, and risk perception. An observational survey was conducted in a randomized group of vending sites (34 pharmacies; 87 shops and markets), in three cities (Yaoundé, Foumbot, Bafoussam) in Cameroon (two regions), and in two cities (Lagos, Port Harcourt) in Nigeria (two states). Interviews in vending sites and group discussions were conducted with 248 mothers. Cameroon and Nigeria showed a largely comparable situation. Plastic baby bottles are largely imported from industrialized countries, where a label indicates the presence/absence of BPA. In pharmacies most plastic baby bottles are labeled as BPA-free, whereas most bottles sold in shops are not BPA-free. BPA-containing bottles are more accessible and affordable, due to sale in common shops and lower costs. The meaning of the label BPA-free is unknown to both vendors and customers: the BPA issue is also largely unknown to policy makers and media and no regulation exists on food contact materials. The wide availability of BPA-containing baby bottles, lack of information and usage patterns (e.g. temperature and duration of heating) suggest a likely widespread exposure of African infants. Possible usage recommendations to mitigate exposure are indicated. Risk communication to policy makers, sellers and citizens is paramount to raise awareness and to oppose possible dumping from countries where BPA-containing materials are banned. Our pilot study points out relevant global health issues such as the capacity building of African communities on informed choices and usage of baby products, and the exploitation of international knowledge by African scientists and risk managers. Copyright © 2014 Elsevier B.V. All rights reserved.

Usual interstitial pneumonia: typical, possible, and “inconsistent” patterns

PubMed Central

Torres, Pedro Paulo Teixeira e Silva; Rabahi, Marcelo Fouad; Moreira, Maria Auxiliadora Carmo; Meirelles, Gustavo de Souza Portes; Marchiori, Edson

2017-01-01

ABSTRACT Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated “possible UIP”; and a pattern designated “inconsistent with UIP”, each pattern having important diagnostic implications. A typical UIP pattern on HRCT is highly accurate for the presence of histopathological UIP, being currently considered to be diagnostic of UIP. The remaining patterns require further diagnostic investigation. Other known causes of a UIP pattern include drug-induced interstitial lung disease, chronic hypersensitivity pneumonitis, occupational diseases (e.g., asbestosis), and connective tissue diseases, all of which should be included in the clinical differential diagnosis. Given the importance of CT studies in establishing a diagnosis and the possibility of interobserver variability, the objective of this pictorial essay was to illustrate all three UIP patterns on HRCT. PMID:29160385

The development of wing shape in Lepidoptera: mitotic density, not orientation, is the primary determinant of shape.

PubMed

Nijhout, H Frederik; Cinderella, Margaret; Grunert, Laura W

2014-03-01

The wings of butterflies and moths develop from imaginal disks whose structure is always congruent with the final adult wing. It is therefore possible to map every point on the imaginal disk to a location on the adult wing throughout ontogeny. We studied the growth patterns of the wings of two distantly related species with very different adult wing shapes, Junonia coenia and Manduca sexta. The shape of the wing disks change throughout their growth phase in a species-specific pattern. We measured mitotic densities and mitotic orientation in successive stages of wing development approximately one cell division apart. Cell proliferation was spatially patterned, and the density of mitoses was highly correlated with local growth. Unlike other systems in which the direction of mitoses has been viewed as the primary determinant of directional growth, we found that in these two species the direction of growth was only weakly correlated with the orientation of mitoses. Directional growth appears to be imposed by a constantly changing spatial pattern of cell division coupled with a weak bias in the orientation of cell division. Because growth and cell division in imaginal disk require ecdysone and insulin signaling, the changing spatial pattern of cell division may due to a changing pattern of expression of receptors or downstream elements in the signaling pathways for one or both of these hormones. Evolution of wing shape comes about by changes in the progression of spatial patterns of cell division. © 2014 Wiley Periodicals, Inc.

Movement patterns of limb coordination in infant rolling.

PubMed

Kobayashi, Yoshio; Watanabe, Hama; Taga, Gentaro

2016-12-01

Infants must perform dynamic whole-body movements to initiate rolling, a key motor skill. However, little is known regarding limb coordination and postural control in infant rolling. To address this lack of knowledge, we examined movement patterns and limb coordination during rolling in younger infants (aged 5-7 months) that had just begun to roll and in older infants (aged 8-10 months) with greater rolling experience. Due to anticipated difficulty in obtaining measurements over the second half of the rolling sequence, we limited our analysis to the first half. Ipsilateral and contralateral limbs were identified on the basis of rolling direction and were classified as either a stationary limb used for postural stability or a moving limb used for controlled movement. We classified the observed movement patterns by identifying the number of stationary limbs and the serial order of combinational limb movement patterns. Notably, older infants performed more movement patterns that involved a lower number of stationary limbs than younger infants. Despite the wide range of possible movement patterns, a small group of basic patterns dominated in both age groups. Our results suggest that the fundamental structure of limb coordination during rolling in the early acquisition stages remains unchanged until at least 8-10 months of age. However, compared to younger infants, older infants exhibited a greater ability to select an effective rotational movement by positioning themselves with fewer stationary limbs and performing faster limb movements.

Sawmill simulation: data instructions and computer programs

Treesearch

Hugh W. Reynolds; Hugh W. Reynolds

1970-01-01

Sawmill production managers often find it hard to tell what sawing pattern will yield the most. If sample logs are sawed in one sawing pattern, they cannot be reassembled and sawed again in a different pattern. And if a new sample of logs is used for each new sawing pattern, it is hard to tell if differences in yield are due to the sawing patterns or are due to natural...

Quantifying the variability of potential black carbon transport from cropland burning in Russia driven by atmospheric blocking events

NASA Astrophysics Data System (ADS)

Hall, Joanne; Loboda, Tatiana

2018-05-01

The deposition of short-lived aerosols and pollutants on snow above the Arctic Circle transported from northern mid-latitudes have amplified the short term warming in the Arctic region. Specifically, black carbon has received a great deal of attention due to its absorptive efficiency and its fairly complex influence on the climate. Cropland burning in Russia is a large contributor to the black carbon emissions deposited directly onto the snow in the Arctic region during the spring when the impact on the snow/ice albedo is at its highest. In this study, our focus is on identifying a possible atmospheric pattern that may enhance the transport of black carbon emissions from cropland burning in Russia to the snow-covered Arctic. Specifically, atmospheric blocking events are large-scale patterns in the atmospheric pressure field that are nearly stationary and act to block migratory cyclones. The persistent low-level wind patterns associated with these mid-latitude weather patterns are likely to accelerate potential transport and increase the success of transport of black carbon emissions to the snow-covered Arctic during the spring. Our results revealed that overall, in March, the transport time of hypothetical black carbon emissions from Russian cropland burning to the Arctic snow is shorter (in some areas over 50 hours less at higher injection heights) and the success rate is also much higher (in some areas up to 100% more successful) during atmospheric blocking conditions as compared to conditions without an atmospheric blocking event. The enhanced transport of black carbon has important implications for the efficacy of deposited black carbon. Therefore, understanding these relationships could lead to possible mitigation strategies for reducing the impact of deposition of black carbon from crop residue burning in the Arctic.

A Learning System for Discriminating Variants of Malicious Network Traffic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beaver, Justin M; Symons, Christopher T; Gillen, Rob

Modern computer network defense systems rely primarily on signature-based intrusion detection tools, which generate alerts when patterns that are pre-determined to be malicious are encountered in network data streams. Signatures are created reactively, and only after in-depth manual analysis of a network intrusion. There is little ability for signature-based detectors to identify intrusions that are new or even variants of an existing attack, and little ability to adapt the detectors to the patterns unique to a network environment. Due to these limitations, the need exists for network intrusion detection techniques that can more comprehensively address both known unknown networkbased attacksmore » and can be optimized for the target environment. This work describes a system that leverages machine learning to provide a network intrusion detection capability that analyzes behaviors in channels of communication between individual computers. Using examples of malicious and non-malicious traffic in the target environment, the system can be trained to discriminate between traffic types. The machine learning provides insight that would be difficult for a human to explicitly code as a signature because it evaluates many interdependent metrics simultaneously. With this approach, zero day detection is possible by focusing on similarity to known traffic types rather than mining for specific bit patterns or conditions. This also reduces the burden on organizations to account for all possible attack variant combinations through signatures. The approach is presented along with results from a third-party evaluation of its performance.« less

Cutaneous gallium uptake in patients with AIDS with mycobacterium avium-intracellulare septicemia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allwright, S.J.; Chapman, P.R.; Antico, V.F.

1988-07-01

Gallium imaging is increasingly being used for the early detection of complications in patients with AIDS. A 26-year-old homosexual man who was HIV antibody positive underwent gallium imaging for investigation of possible Pneumocystis carinii pneumonia. Widespread cutaneous focal uptake was seen, which was subsequently shown to be due to mycobacterium avium-intracellulare (MAI) septicemia. This case demonstrates the importance of whole body imaging rather than imaging target areas only, the utility of gallium imaging in aiding the early detection of clinically unsuspected disease, and shows a new pattern of gallium uptake in disseminated MAI infection.

Carbon contamination topography analysis of EUV masks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, Y.-J.; Yankulin, L.; Thomas, P.

2010-03-12

The impact of carbon contamination on extreme ultraviolet (EUV) masks is significant due to throughput loss and potential effects on imaging performance. Current carbon contamination research primarily focuses on the lifetime of the multilayer surfaces, determined by reflectivity loss and reduced throughput in EUV exposure tools. However, contamination on patterned EUV masks can cause additional effects on absorbing features and the printed images, as well as impacting the efficiency of cleaning process. In this work, several different techniques were used to determine possible contamination topography. Lithographic simulations were also performed and the results compared with the experimental data.

The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults.

PubMed

Tolentino, Jerlyn C; Pirogovsky, Eva; Luu, Trinh; Toner, Chelsea K; Gilbert, Paul E

2012-05-21

Two experiments tested the effect of temporal interference on order memory for fixed and random sequences in young adults and nondemented older adults. The results demonstrate that temporal order memory for fixed and random sequences is impaired in nondemented older adults, particularly when temporal interference is high. However, temporal order memory for fixed sequences is comparable between older adults and young adults when temporal interference is minimized. The results suggest that temporal order memory is less efficient and more susceptible to interference in older adults, possibly due to impaired temporal pattern separation.

Perception of suprasegmental features of speech by children with cochlear implants and children with hearing AIDS.

PubMed

Most, Tova; Peled, Miriam

2007-01-01

This study assessed perception of suprasegmental features of speech by 30 prelingual children with sensorineural hearing loss. Ten children had cochlear implants (CIs), and 20 children wore hearing aids (HA): 10 with severe hearing loss and 10 with profound hearing loss. Perception of intonation, syllable stress, word emphasis, and word pattern was assessed. Results revealed that the two HA groups significantly outperformed the CI group in perceiving both intonation and stress. Within each group, word pattern was perceived best, and then intonation and emphasis, with syllable stress perceived poorest. No significant correlation emerged between age at implantation and perception of the various suprasegmental features, possibly due to participants' relatively late age at implantation. Results indicated that CI use did not show an advantage over HA use in the perception of suprasegmental features of speech. Future research should continue to explore variables that might improve this perception.

Frustration in Condensed Matter and Protein Folding

NASA Astrophysics Data System (ADS)

Lorelli, S.; Cabot, A.; Sundarprasad, N.; Boekema, C.

Using computer modeling we study frustration in condensed matter and protein folding. Frustration is due to random and/or competing interactions. One definition of frustration is the sum of squares of the differences between actual and expected distances between characters. If this sum is non-zero, then the system is said to have frustration. A simulation tracks the movement of characters to lower their frustration. Our research is conducted on frustration as a function of temperature using a logarithmic scale. At absolute zero, the relaxation for frustration is a power function for randomly assigned patterns or an exponential function for regular patterns like Thomson figures. These findings have implications for protein folding; we attempt to apply our frustration modeling to protein folding and dynamics. We use coding in Python to simulate different ways a protein can fold. An algorithm is being developed to find the lowest frustration (and thus energy) states possible. Research supported by SJSU & AFC.

Visual Discomfort From Flash Afterimages of Riloid Patterns.

PubMed

O'Hare, Louise

2017-06-01

Op-art-based stimuli have been shown to be uncomfortable, possibly due to a combination of fixational eye movements (microsaccades) and excessive cortical responses. Efforts have been made to measure illusory phenomena arising from these stimuli in the absence of microsaccades, but there has been no attempt thus far to decouple the effects of the cortical response from the effect of fixational eye movements. This study uses flash afterimages to stabilise the image on the retina and thus reduce the systematic effect of eye movements, in order to investigate the role of the brain in discomfort from op-art-based stimuli. There was a relationship between spatial frequency and the magnitude of the P300 response, showing a similar pattern to that of discomfort judgements, which suggests that there might be a role of discomfort and excessive neural responses independently from the effects of microsaccades.

Data preparation and evaluation techniques for x-ray diffraction microscopy

DOE PAGES

Steinbrener, Jan; Nelson, Johanna; Huang, Xiaojing; ...

2010-01-01

The post-experiment processing of X-ray Diffraction Microscopy data is often time-consuming and difficult. This is mostly due to the fact that even if a preliminary result has been reconstructed, there is no definitive answer as to whether or not a better result with more consistently retrieved phases can still be obtained. In addition, we show here that the first step in data analysis, the assembly of two-dimensional diffraction patterns from a large set of raw diffraction data, is crucial to obtaining reconstructions of highest possible consistency. We have developed software that automates this process and results in consistently accurate diffractionmore » patterns. We have furthermore derived some criteria of validity for a tool commonly used to assess the consistency of reconstructions, the phase retrieval transfer function, and suggest a modified version that has improved utility for judging reconstruction quality.« less

Fractures on Europa - Possible response of an ice crust to tidal deformation

NASA Technical Reports Server (NTRS)

Helfenstein, P.; Parmentier, E. M.

1980-01-01

The surface of Europa contains a planetwide system of low albedo lineaments which have been interpreted as fractures in an icy crust. The pattern of fractures on the surface consists of radial and concentric fractures having the general appearance of tension cracks within a region near the antipode of the sub-Jupiter point. Outside this region, linear fractures intersect at angles near 60 deg, suggesting that they are conjugate shear fractures. The orientation of this pattern on the surface suggests that a principal axis of the deformation that produced the fractures was approximately radial to Jupiter. Fracturing may thus be consistent with an origin due to cyclical tidal deformation resulting from orbital eccentricity. Orbital eccentricity related to a relatively recent establishment of orbital resonance among the Galilean satellites may explain the presence of fractures in a relatively young, lightly cratered planetary surface.

Image processing and recognition for biological images

PubMed Central

Uchida, Seiichi

2013-01-01

This paper reviews image processing and pattern recognition techniques, which will be useful to analyze bioimages. Although this paper does not provide their technical details, it will be possible to grasp their main tasks and typical tools to handle the tasks. Image processing is a large research area to improve the visibility of an input image and acquire some valuable information from it. As the main tasks of image processing, this paper introduces gray-level transformation, binarization, image filtering, image segmentation, visual object tracking, optical flow and image registration. Image pattern recognition is the technique to classify an input image into one of the predefined classes and also has a large research area. This paper overviews its two main modules, that is, feature extraction module and classification module. Throughout the paper, it will be emphasized that bioimage is a very difficult target for even state-of-the-art image processing and pattern recognition techniques due to noises, deformations, etc. This paper is expected to be one tutorial guide to bridge biology and image processing researchers for their further collaboration to tackle such a difficult target. PMID:23560739

Phase-Contrast MRI and CFD Modeling of Apparent 3He Gas Flow in Rat Pulmonary Airways

PubMed Central

Minard, Kevin R.; Kuprat, Andrew P.; Kabilan, Senthil; Jacob, Richard E.; Einstein, Daniel R.; Carson, James P.; Corley, Richard A.

2012-01-01

Phase-contrast (PC) magnetic resonance imaging (MRI) with hyperpolarized 3He is potentially useful for developing and testing patient-specific models of pulmonary airflow. One challenge, however, is that PC-MRI provides apparent values of local 3He velocity that not only depend on actual airflow but also on gas diffusion. This not only blurs laminar flow patterns in narrow airways but also introduces anomalous airflow structure that reflects gas-wall interactions. Here, both effects are predicted in a live rat using computational fluid dynamics (CFD), and for the first time, simulated patterns of apparent 3He gas velocity are compared with in-vivo PC-MRI. Results show 1) that correlations (R2) between measured and simulated airflow patterns increase from 0.23 to 0.79 simply by accounting for apparent 3He transport, and 2) that remaining differences are mainly due to uncertain airway segmentation and partial volume effects stemming from relatively coarse MRI resolution. Higher-fidelity testing of pulmonary airflow predictions should therefore be possible with future imaging improvements. PMID:22771528

Triple/quadruple patterning layout decomposition via linear programming and iterative rounding

NASA Astrophysics Data System (ADS)

Lin, Yibo; Xu, Xiaoqing; Yu, Bei; Baldick, Ross; Pan, David Z.

2017-04-01

As the feature size of the semiconductor technology scales down to 10 nm and beyond, multiple patterning lithography (MPL) has become one of the most practical candidates for lithography, along with other emerging technologies, such as extreme ultraviolet lithography (EUVL), e-beam lithography (EBL), and directed self-assembly. Due to the delay of EUVL and EBL, triple and even quadruple patterning is considered to be used for lower metal and contact layers with tight pitches. In the process of MPL, layout decomposition is the key design stage, where a layout is split into various parts and each part is manufactured through a separate mask. For metal layers, stitching may be allowed to resolve conflicts, whereas it is forbidden for contact and via layers. We focus on the application of layout decomposition where stitching is not allowed, such as for contact and via layers. We propose a linear programming (LP) and iterative rounding solving technique to reduce the number of nonintegers in the LP relaxation problem. Experimental results show that the proposed algorithms can provide high quality decomposition solutions efficiently while introducing as few conflicts as possible.

Ferro-Lattice-Distortions and Charge Fluctuations in Superconducting LaO 1- x F x BiS 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Athauda, Anushika; Hoffmann, Christina; Aswartham, Saicharan

2017-05-15

Competing ferroelectric and charge density wave states have been proposed to exist in the electron–phonon coupled LaO1-xFxBiS2 superconductor. The lattice instability is proposed to arise from unstable phonon modes that can break the crystal symmetry. Using single crystal diffraction, a superlattice pattern is observed, that arises from coherent in-plane displacements of the sulfur atoms in the BiS2 superconducting planes. The distortions morph into coordinated ferrodistortive patterns with displacements in the x- and y-directions, that alternate along the c-axis. Diffuse scattering is observed along the (H0L) plane due to stacking faults but not along the (HH0) plane. The ferro-distortive pattern remainsmore » in the superconducting state upon fluorine doping, but the displacements are diminished in magnitude. Moreover, we find that the in-plane distortions give rise to disorder where the (00L) reflections become quite broad. It is possible that charge carriers can get trapped in the lattice deformations reducing the effective number of carriers available for pairing.« less

Neospora caninum abortion in a Malayan tapir (Tapirus indicus).

PubMed

Peters, M; Osmann, C; Wohlsein, P; Schares, G

2017-05-30

A captive 17-year old female Malayan tapir (Tapirus indicus) aborted a fetus with a crown rump length of 19cm in early pregnancy. The fetus showed an early state of mummification. Histologically, a multifocal mononuclear encephalitis, myocarditis and periportal hepatitis was present indicating a possible protozoal cause of abortion. Although immunohistologically, Neospora (N.) caninum antigen could not be demonstrated, N. caninum DNA was detected by Polymerase Chain Reaction (PCR) in brain, heart, liver and lung of the fetus. N. caninum DNA was extracted from the aborted fetus and the microsatellite marker MS10 was amplified by PCR and sequenced. The obtained MS10 microsatellite pattern has not been described in Germany yet. Nevertheless, the MS10 pattern was very similar to those reported for N. caninum isolated from dogs and cattle in Germany. Because of the histological pattern and extent of the lesions, neosporosis was suspected as the cause of fetal death and abortion. This case report describes for the first time transplacental transmission of N. caninum and abortion due to neosporosis in a tapir. Copyright © 2017 Elsevier B.V. All rights reserved.

Phase-contrast MRI and CFD modeling of apparent 3He gas flow in rat pulmonary airways

NASA Astrophysics Data System (ADS)

Minard, Kevin R.; Kuprat, Andrew P.; Kabilan, Senthil; Jacob, Richard E.; Einstein, Daniel R.; Carson, James P.; Corley, Richard A.

2012-08-01

Phase-contrast (PC) magnetic resonance imaging (MRI) with hyperpolarized 3He is potentially useful for developing and testing patient-specific models of pulmonary airflow. One challenge, however, is that PC-MRI provides apparent values of local 3He velocity that not only depend on actual airflow but also on gas diffusion. This not only blurs laminar flow patterns in narrow airways but also introduces anomalous airflow structure that reflects gas-wall interactions. Here, both effects are predicted in a live rat using computational fluid dynamics (CFD), and for the first time, simulated patterns of apparent 3He gas velocity are compared with in vivo PC-MRI. Results show (1) that correlations (R2) between measured and simulated airflow patterns increase from 0.23 to 0.79 simply by accounting for apparent 3He transport, and (2) that remaining differences are mainly due to uncertain airway segmentation and partial volume effects stemming from relatively coarse MRI resolution. Higher-fidelity testing of pulmonary airflow predictions should therefore be possible with future imaging improvements.

Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks

PubMed Central

González-Garrido, Andrés A.; Gudayol-Ferré, Esteban; Guàrdia-Olmos, Joan

2015-01-01

In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1D versus healthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects. PMID:26266268

Thermodiffusion as a means to manipulate liquid film dynamics on chemically patterned surfaces

PubMed Central

Kalpathy, Sreeram K.; Shreyes, Amrita Ravi

2017-01-01

The model problem examined here is the stability of a thin liquid film consisting of two miscible components, resting on a chemically patterned solid substrate and heated from below. In addition to surface tension gradients, the temperature variations also induce gradients in the concentration of the film by virtue of thermodiffusion/Soret effects. We study the stability and dewetting behaviour due to the coupled interplay between thermal gradients, Soret effects, long-range van der Waals forces, and wettability gradient-driven flows. Linear stability analysis is first employed to predict growth rates and the critical Marangoni number for chemically homogeneous surfaces. Then, nonlinear simulations are performed to unravel the interfacial dynamics and possible locations of the film rupture on chemically patterned substrates. Results suggest that appropriate tuning of the Soret parameter and its direction, in conjunction with either heating or cooling, can help manipulate the location and time scales of the film rupture. The Soret effect can either potentially aid or oppose film instability depending on whether the thermal and solutal contributions to flow are cooperative or opposed to each other. PMID:28595391

The neural basis for category-specific knowledge: an fMRI study.

PubMed

Grossman, Murray; Koenig, Phyllis; DeVita, Chris; Glosser, Guila; Alsop, David; Detre, John; Gee, James

2002-04-01

Functional neuroimaging studies of healthy adults have associated different categories of knowledge with distinct activation patterns. The basis for these recruitment patterns has been controversial, due in part to the limited range of categories that has been studied. We used fMRI to monitor regional cortical recruitment patterns while subjects were exposed to printed names of Animals, Implements, and Abstract nouns. Both Implements and Abstract nouns were related to recruitment of left posterolateral temporal cortex and left prefrontal cortex, and Abstract nouns additionally recruited posterolateral temporal and prefrontal regions of the right hemisphere. Animals were associated with activation of ventral-medial occipital cortex in the left hemisphere at a level that approaches significance. These findings are not consistent with the "sensory-motor" model proposed to explain the neural representation of word knowledge. We suggest instead a neural model of semantic memory that reflects the processes common to understanding Implements and Abstract nouns and a selective sensitivity, possibly evolving from adaptive pressures, to the overlapping, intercorrelated visual characteristics of Animals. (C)2002 Elsevier Science (USA).

Design and characterization of a mapping device optimized to collect XRD patterns from highly inhomogeneous and low density powder samples

NASA Astrophysics Data System (ADS)

D'Elia, A.; Cibin, G.; Robbins, P. E.; Maggi, V.; Marcelli, A.

2017-11-01

We report on the development of a device designed to improve X-ray Powder Diffraction data acquisition through mapping coupled to a rotational motion of the sample. The device and procedures developed aim at overcoming the experimental issues that accompany the analysis of inhomogeneous samples, such as powders, dust or aerosols deposited on a flat substrate. Introducing the mapping of the substrate on which powders are deposited and at the same time the rotation, we may overcome drawbacks associated to inhomogeneous distributions such as ring-like patterns due to the coffee stain effect generated by the evaporation of a solution. Experimental data have been collected from powders of a NIST standard soil sample (11 μg) and from an airborne dust extracted from deep ice cores in Antarctica (9.6 μg). Both particulate samples have been deposited on polycarbonate membranes from ultra-dilute solutions. Data show that this approach makes possible to collect XRD patterns useful to identify mineral fractions present in these low density samples.

Establishing the behavioural limits for countershaded camouflage.

PubMed

Penacchio, Olivier; Harris, Julie M; Lovell, P George

2017-10-20

Countershading is a ubiquitous patterning of animals whereby the side that typically faces the highest illumination is darker. When tuned to specific lighting conditions and body orientation with respect to the light field, countershading minimizes the gradient of light the body reflects by counterbalancing shadowing due to illumination, and has therefore classically been thought of as an adaptation for visual camouflage. However, whether and how crypsis degrades when body orientation with respect to the light field is non-optimal has never been studied. We tested the behavioural limits on body orientation for countershading to deliver effective visual camouflage. We asked human participants to detect a countershaded target in a simulated three-dimensional environment. The target was optimally coloured for crypsis in a reference orientation and was displayed at different orientations. Search performance dramatically improved for deviations beyond 15 degrees. Detection time was significantly shorter and accuracy significantly higher than when the target orientation matched the countershading pattern. This work demonstrates the importance of maintaining body orientation appropriate for the displayed camouflage pattern, suggesting a possible selective pressure for animals to orient themselves appropriately to enhance crypsis.

Colorization-Based RGB-White Color Interpolation using Color Filter Array with Randomly Sampled Pattern

PubMed Central

Oh, Paul; Lee, Sukho; Kang, Moon Gi

2017-01-01

Recently, several RGB-White (RGBW) color filter arrays (CFAs) have been proposed, which have extra white (W) pixels in the filter array that are highly sensitive. Due to the high sensitivity, the W pixels have better SNR (Signal to Noise Ratio) characteristics than other color pixels in the filter array, especially, in low light conditions. However, most of the RGBW CFAs are designed so that the acquired RGBW pattern image can be converted into the conventional Bayer pattern image, which is then again converted into the final color image by using conventional demosaicing methods, i.e., color interpolation techniques. In this paper, we propose a new RGBW color filter array based on a totally different color interpolation technique, the colorization algorithm. The colorization algorithm was initially proposed for colorizing a gray image into a color image using a small number of color seeds. Here, we adopt this algorithm as a color interpolation technique, so that the RGBW color filter array can be designed with a very large number of W pixels to make the most of the highly sensitive characteristics of the W channel. The resulting RGBW color filter array has a pattern with a large proportion of W pixels, while the small-numbered RGB pixels are randomly distributed over the array. The colorization algorithm makes it possible to reconstruct the colors from such a small number of RGB values. Due to the large proportion of W pixels, the reconstructed color image has a high SNR value, especially higher than those of conventional CFAs in low light condition. Experimental results show that many important information which are not perceived in color images reconstructed with conventional CFAs are perceived in the images reconstructed with the proposed method. PMID:28657602

Colorization-Based RGB-White Color Interpolation using Color Filter Array with Randomly Sampled Pattern.

PubMed

Oh, Paul; Lee, Sukho; Kang, Moon Gi

2017-06-28

Recently, several RGB-White (RGBW) color filter arrays (CFAs) have been proposed, which have extra white (W) pixels in the filter array that are highly sensitive. Due to the high sensitivity, the W pixels have better SNR (Signal to Noise Ratio) characteristics than other color pixels in the filter array, especially, in low light conditions. However, most of the RGBW CFAs are designed so that the acquired RGBW pattern image can be converted into the conventional Bayer pattern image, which is then again converted into the final color image by using conventional demosaicing methods, i.e., color interpolation techniques. In this paper, we propose a new RGBW color filter array based on a totally different color interpolation technique, the colorization algorithm. The colorization algorithm was initially proposed for colorizing a gray image into a color image using a small number of color seeds. Here, we adopt this algorithm as a color interpolation technique, so that the RGBW color filter array can be designed with a very large number of W pixels to make the most of the highly sensitive characteristics of the W channel. The resulting RGBW color filter array has a pattern with a large proportion of W pixels, while the small-numbered RGB pixels are randomly distributed over the array. The colorization algorithm makes it possible to reconstruct the colors from such a small number of RGB values. Due to the large proportion of W pixels, the reconstructed color image has a high SNR value, especially higher than those of conventional CFAs in low light condition. Experimental results show that many important information which are not perceived in color images reconstructed with conventional CFAs are perceived in the images reconstructed with the proposed method.

[Characteristics of auto-CPAP devices during the simulation of sleep-related breathing flow patterns].

PubMed

Rühle, K H; Karweina, D; Domanski, U; Nilius, G

2009-07-01

The function of automatic CPAP devices is difficult to investigate using clinical examinations due to the high variability of breathing disorders. With a flow generator, however, identical breathing patterns can be reproduced so that comparative studies on the behaviour of pressure of APAP devices are possible. Because the algorithms of APAP devices based on the experience of users can be modified without much effort, also previously investigated devices should regularly be reviewed with regard to programme changes. Had changes occurred in the algorithms of 3 selected devices--compared to the previously published benchmark studies? Do the current versions of these investigated devices differentiate between open and closed apnoeas? With a self-developed respiratory pump, sleep-related breathing patterns and, with the help of a computerised valve, resistances of the upper respiratory tract were simulated. Three different auto-CPAP devices were subjected to a bench test with and without feedback (open/closed loop). Open loop: the 3 devices showed marked differences in the rate of pressure rise but did not differ from the earlier published results. From an initial pressure of 4 mbar the pressure increased to 10 mbar after a different number of apnoeas (1-6 repetitive apnoeas). Only one device differentiated between closed and open apnoeas. Closed loop: due to the pressure increase, the flow generator simulated reduced obstruction of the upper airways (apnoeas changed to hypopnoeas, hypopnoeas changed to flattening) but different patterns of pressure regulation could still be observed. By applying bench-testing, the algorithms of auto-CPAP devices can regularly be reviewed to detect changes in the software. The differentiation between open and closed apnoeas should be improved in several APAP devices.

Long-term analysis of spatio-temporal patterns in population dynamics and demography of juvenile Pinfish (Lagodon rhomboides)

NASA Astrophysics Data System (ADS)

Chacin, D. H.; Switzer, T. S.; Ainsworth, C. H.; Stallings, C. D.

2016-12-01

In estuarine systems, proximity to the ocean has the potential to directly and indirectly drive patterns of fish distribution and population dynamics. To test this hypothesis, we conducted a comprehensive analysis of fisheries-independent data and quantified patterns of density, biomass, and growth rates of juvenile Pinfish (Lagodon rhomboides) across spatial and temporal scales in Tampa Bay, Florida, USA. Spatially, the highest density and biomass were found in the outermost regions (closest to the Gulf of Mexico) of the Bay, and these patterns were generally consistent temporally. Inter-annually, Pinfish density and biomass were the highest during periods coinciding with favorable oceanographic conditions (e.g., anomalously intense and prolonged upwelling) for across-shelf transport of larvae from spawning grounds in the Gulf to Tampa Bay. Intra-annually, density and biomass were the highest during spring and summer likely due to the combined effects of spawning timing (and delivery of new settlers), and high somatic growth fueled by increased secondary and primary productivity. Declines in density and biomass during the late summer through early winter were possibly due to high post-settlement mortality and egress to offshore habitats. Pinfish increased predictably in size across the months of the calendar year, and tended to be larger and grew faster in the innermost regions of the Bay, which were located farthest from the Gulf. Pinfish density was related to the proximity to the Gulf of Mexico, with the outermost regions of the Bay having greater seagrass cover, higher salinity, and being closer to the offshore larval pool where spawning occurs. Thus, this study provided evidence that distance to the ocean was an important driver of biotic and abiotic factors that influenced Pinfish demographic rates across spatial and temporal scales in the largest estuary in Florida.

The mean zonal flow response to Rossby wave and gravity wave forcing in the equatorial lower stratosphere - Relationship to the QBO

NASA Technical Reports Server (NTRS)

Takahashi, Masaaki; Holton, James R.

1991-01-01

Observations show that the westerly acceleration of the equatorial quasi-biennial oscillation (QBO) can be accounted for by Kelvin waves, but that there is a deficiency in the easterly acceleration due to Rossby-gravity waves. Rossby waves and westward propagating gravity waves have been suggested as alternative sources for the easterly acceleration. The possible role of these two wave modes has been tested in a two-dimensional model of the QBO. When the easterly acceleration is due to Rossby waves, the zonal-mean response is steady; when it is due to gravity waves, an oscillation with some features similar to the QBO occurs, but it is of short period and weak amplitude. A similar result occurs when a standing-wave forcing pattern is imposed. These results suggest that Rossby waves play only a minor role in the QBO, and that while the Rossby-gravity mode is essential, other gravity modes may also be important for the easterly phase.

Automated Removal of Bad-Baseline Spectra from ACSIS/HARP Heterodyne Time Series

NASA Astrophysics Data System (ADS)

Currie, M. J.

2013-10-01

Heterodyne time-series spectral data often exhibit distorted or noisy baselines. These are either transient due to external interference or pickup; or affect a receptor throughout an observation or extended period, possibly due to a poor cable connection. While such spectra can be excluded manually, this is time consuming and prone to omission, especially for the high-frequency interference affecting just one or two spectra in typically several to twenty thousand, yet can produce undesirable artifacts in the reduced spectral cube. Further astronomers have tended to reject an entire receptor if any of its spectra are suspect; as a consequence the reduced products have lower signal-to-noise, and enhanced graticule patterns due to the variable coverage and detector relative sensitivities. This paper illustrates some of the types of aberrant spectra for ACSIS/HARP on the James Clerk Maxwell Telescope and the algorithms used to identify and remove them, applied within the ORAC-DR pipeline, and compares an integrated map with and without baseline filtering.

Close coupling of pre- and post-processing vision stations using inexact algorithms

NASA Astrophysics Data System (ADS)

Shih, Chi-Hsien V.; Sherkat, Nasser; Thomas, Peter D.

1996-02-01

Work has been reported using lasers to cut deformable materials. Although the use of laser reduces material deformation, distortion due to mechanical feed misalignment persists. Changes in the lace patten are also caused by the release of tension in the lace structure as it is cut. To tackle the problem of distortion due to material flexibility, the 2VMethod together with the Piecewise Error Compensation Algorithm incorporating the inexact algorithms, i.e., fuzzy logic, neural networks and neural fuzzy technique, are developed. A spring mounted pen is used to emulate the distortion of the lace pattern caused by tactile cutting and feed misalignment. Using pre- and post-processing vision systems, it is possible to monitor the scalloping process and generate on-line information for the artificial intelligence engines. This overcomes the problems of lace distortion due to the trimming process. Applying the algorithms developed, the system can produce excellent results, much better than a human operator.

Blob-hole correlation model for edge turbulence and comparisons with NSTX gas puff imaging data

NASA Astrophysics Data System (ADS)

Myra, J. R.; Zweben, S. J.; Russell, D. A.

2018-07-01

Gas puff imaging (GPI) observations made in NSTX (Zweben et al 2017 Phys. Plasmas 24 102509) have revealed two-point spatial correlations of edge and scrape-off layer (SOL) turbulence in the plane perpendicular to the magnetic field. A common feature is the occurrence of dipole-like patterns with significant regions of negative correlation. In this paper, we explore the possibility that these dipole patterns may be due to blob-hole pairs. Statistical methods are applied to determine the two-point spatial correlation that results from a model of blob-hole pair formation. It is shown that the model produces dipole correlation patterns that are qualitatively similar to the GPI data in several respects. Effects of the reference location (confined surfaces or SOL), a superimposed random background, hole velocity and lifetime, and background sheared flows are explored and discussed with respect to experimental observations. Additional analysis of the experimental GPI dataset is performed to further test this blob-hole correlation model. A time delay two-point spatial correlation study did not reveal inward propagation of the negative correlation structures that were postulated to correspond to holes in the data nor did it suggest that the negative correlation structures are due to neutral shadowing. However, tracking of the highest and lowest values (extrema) of the normalized GPI fluctuations shows strong evidence for mean inward propagation of minima and outward propagation of maxima, in qualitative agreement with theoretical expectations. Other properties of the experimentally observed extrema are discussed.

A multidisciplinary approach to reservoir subdivision of the Maastrichtian chalk in the Dan field, Danish North Sea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kristensen, L.; Dons, T.; Schioler, P.

1995-11-01

Correlation of wireline log data from the North Sea chalk reservoirs is frequently hampered by rather subtle log patterns in the chalk section due to the apparent monotonous nature of the chalk sediments, which may lead to ambiguous correlations. This study deals with a correlation technique based on an integration of biostratigraphic data, seismic interpretation, and wireline log correlation; this technique aims at producing a consistent reservoir subdivision that honors both the well data and the seismic data. This multidisciplinary approach has been used to subdivide and correlate the Maastrichtian chalk in the Dan field. The biostratigraphic subdivision is basedmore » on a new detailed dinoflagellate study of core samples from eight wells. Integrating the biostratigraphic results with three-dimensional seismic data allows recognition of four stratigraphic units within the Maastrichtian, bounded by assumed chronostratigraphic horizons. This subdivision is further refined by adding a seismic horizon and four horizons from wireline log correlations, establishing a total of nine reservoir units. The approximate chronostratigraphic nature of these units provides an improved interpretation of the depositional and structural patterns in this area. The three upper reservoir units pinch out and disappear in a northeasterly direction across the field. We interpret this stratal pattern as reflecting a relative sea level fall or regional basinal subsidence during the latest Maastrichtian, possibly combined with local synsedimentary uplift due to salt tectonics. Isochore maps indicate that the underlying six non-wedging units are unaffected by salt tectonics.« less

Optomechanics of two- and three-dimensional soft photonic crystals

NASA Astrophysics Data System (ADS)

Krishnan, Dwarak

Soft photonic crystals are a class of periodic dielectric structures that undergo highly nonlinear deformation due to strain or other external stimulus such as temperature, pH etc. This can in turn dramatically affect optical properties such as light transmittance. Moreover certain classes of lithographically fabricated structures undergo some structural distortion due to the effects of processing, eventually affecting the optical properties of the final photonic crystal. In this work, we study the deformation mechanics of soft photonic crystal structures using realistic physics-based models and leverage that understanding to explain the optomechanics of actual 2-D and 3-D soft photonic crystals undergoing similar symmetry breaking nonlinear deformations. We first study the optomechanics of two classes of 3-D soft photonic crystals: (1) hydrogel and (2) elastomer based material systems. The hydrogel based inverse face-centered-cubic structure undergoes swelling with change in pH of the surrounding fluid. The inverse structure is a network of bulky domains with thin ligament-like connections, and it undergoes a pattern transformation from FCC to L11 as a result of swelling. A continuum scale poroelasticity based coupled fluid-diffusion FEM model is developed to accurately predict this mechanical behavior. Light transmittance simulation results qualitatively explain the experimentally observed trends in the optical behavior with pH change. The elastomer based, lithographically fabricated material experiences shrinkage induced distortion upon processing. This behavior is modeled using FEM with the material represented by a neo-Hookean constitutive law. The light transmittance calculations for normal incidence are carried out using the transfer matrix method and a good comparison is obtained for the positions of first and second order reflectance peaks. A unit cell based approach is taken to compute the photonic bandstructure to estimate light propagation through the structure for other angles of light incidence. To obtain a detailed picture of the change in optical properties due to a pattern transformation, we study simple 2-D elastomer photonic crystals which undergo an interesting structural pattern transformation from simple circular holes to alternately oriented ellipses in a square lattice due to uniaxial compression. The incident light does not have any effect on the properties of the elastomer material. A decomposition of the deformation gradient quickly shows that the pattern transformation is induced by alternating rotations of the interstitial regions and the bending of interconnecting ligaments. Numerical simulations of light transmittance using vector element based FEM analysis of Maxwells equations shows changes in the light energy localization within the material especially in the high energy/low wavelength regions of the spectra. Additionally, with bandstructure calculations on a unit cell of the structure, the optomechanical behavior is completely explained. Finally, computational evidence is provided for a hypothetical 2-D photonic crystal made of a light-sensitive material, which undergoes a structural pattern transformation primarily due to the effect of incident light. The model takes into account the order kinetics of optically induced isomerization (of trans to cis configuration) in the azobenzene-liquid crystal elastomer to compute the transformational strain. This strain, in turn, deforms the structure and hence changes its periodicity and dielectric properties and thus affects the manner in which light gets localized within the material system. This consequently changes the profile of the imposed transformational strain on the deformed structure. The macroscopic strain history shows that prior to the mechanical instability that causes the pattern transformation, there is a period of structural relaxation which initiates the pattern transformation. After the symmetry breaking pattern transformation, the photonic bandstructure is altered significantly. Light does not get localized in the spot regions anymore and stress relaxation dominates. Due to this, the compressive macroscopic strain of the pattern transformed structure starts to decrease indicating a possible cyclical behavior.

Evolution-development congruence in pattern formation dynamics: Bifurcations in gene expression and regulation of networks structures.

PubMed

Kohsokabe, Takahiro; Kaneko, Kunihiko

2016-01-01

Search for possible relationships between phylogeny and ontogeny is important in evolutionary-developmental biology. Here we uncover such relationships by numerical evolution and unveil their origin in terms of dynamical systems theory. By representing developmental dynamics of spatially located cells with gene expression dynamics with cell-to-cell interaction under external morphogen gradient, gene regulation networks are evolved under mutation and selection with the fitness to approach a prescribed spatial pattern of expressed genes. For most numerical evolution experiments, evolution of pattern over generations and development of pattern by an evolved network exhibit remarkable congruence. Both in the evolution and development pattern changes consist of several epochs where stripes are formed in a short time, while for other temporal regimes, pattern hardly changes. In evolution, these quasi-stationary regimes are generations needed to hit relevant mutations, while in development, they are due to some gene expression that varies slowly and controls the pattern change. The morphogenesis is regulated by combinations of feedback or feedforward regulations, where the upstream feedforward network reads the external morphogen gradient, and generates a pattern used as a boundary condition for the later patterns. The ordering from up to downstream is common in evolution and development, while the successive epochal changes in development and evolution are represented as common bifurcations in dynamical-systems theory, which lead to the evolution-development congruence. Mechanism of exceptional violation of the congruence is also unveiled. Our results provide a new look on developmental stages, punctuated equilibrium, developmental bottlenecks, and evolutionary acquisition of novelty in morphogenesis. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Published by Wiley Periodicals, Inc.

Evolution‐development congruence in pattern formation dynamics: Bifurcations in gene expression and regulation of networks structures

PubMed Central

Kohsokabe, Takahiro

2016-01-01

ABSTRACT Search for possible relationships between phylogeny and ontogeny is important in evolutionary‐developmental biology. Here we uncover such relationships by numerical evolution and unveil their origin in terms of dynamical systems theory. By representing developmental dynamics of spatially located cells with gene expression dynamics with cell‐to‐cell interaction under external morphogen gradient, gene regulation networks are evolved under mutation and selection with the fitness to approach a prescribed spatial pattern of expressed genes. For most numerical evolution experiments, evolution of pattern over generations and development of pattern by an evolved network exhibit remarkable congruence. Both in the evolution and development pattern changes consist of several epochs where stripes are formed in a short time, while for other temporal regimes, pattern hardly changes. In evolution, these quasi‐stationary regimes are generations needed to hit relevant mutations, while in development, they are due to some gene expression that varies slowly and controls the pattern change. The morphogenesis is regulated by combinations of feedback or feedforward regulations, where the upstream feedforward network reads the external morphogen gradient, and generates a pattern used as a boundary condition for the later patterns. The ordering from up to downstream is common in evolution and development, while the successive epochal changes in development and evolution are represented as common bifurcations in dynamical‐systems theory, which lead to the evolution‐development congruence. Mechanism of exceptional violation of the congruence is also unveiled. Our results provide a new look on developmental stages, punctuated equilibrium, developmental bottlenecks, and evolutionary acquisition of novelty in morphogenesis. J. Exp. Zool. (Mol. Dev. Evol.) 326B:61–84, 2016. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Published by Wiley Periodicals, Inc. PMID:26678220

[Treatment strategies for mass casualty incidents and terrorist attacks in trauma and vascular surgery : Presentation of a treatment concept].

PubMed

Friemert, B; Franke, A; Bieler, D; Achatz, A; Hinck, D; Engelhardt, M

2017-10-01

The treatment of patients in the context of mass casualty incidents (MCI) represents a great challenge for the participating rescue workers and clinics. Due to the increase in terrorist activities it is necessary to become familiar with this new kind of threat to civilization with respect to the medical treatment of victims of terrorist attacks. There are substantial differences between a "normal" MCI and a terrorist MCI with respect to injury patterns (blunt trauma vs. penetrating/perforating trauma), the type and form of the incident (MCI=static situation vs. terrorist attack MCI= dynamic situation) and the different security positions (rescue services vs. police services). This article is concerned with question of which changes in the surgical treatment of patients are made necessary by these new challenges. In this case it is necessary that physicians are familiar with the different injury patterns, whereby priority must be given to gunshot and explosion (blast) injuries. Furthermore, altered strategic and tactical approaches (damage control surgery vs. tactical abbreviated surgical care) are necessary to ensure survival for as many victims of terrorist attacks as possible and also to achieve the best possible functional results. It is only possible to successfully counter these new challenges by changing the mindset in the treatment of terrorist MCI compared to MCI incidents. An essential component of this mindset is the acquisition of a maximum of flexibility. This article would like to make a contribution to this problem.

A laser induced local transfer for patterning of RGB-OLED-displays

NASA Astrophysics Data System (ADS)

Kroeger, Michael; Hueske, Marc; Dobbertin, Thomas; Meyer, Jens; Krautwald, Henning; Riedl, Thomas; Johannes, Hans-Hermann; Kowalsky, Wolfgang

2005-07-01

RGB-OLED-displays can be realized by at least three different approaches: Color from white, color from blue or patterning of red, green and blue OLEDs, which is favorable for reasons of higher efficiency and lower costs. Common patterning techniques like photolithography cannot be applied due to the degradation of the OLEDs after the exposure to solvents. Shadow masking which is currently widely applied is not applicable for bigger substrate sizes of future mass production tools. Therefore a novel approach for patterning of organic semiconductors will be demonstrated. The laser induced local transfer (LILT) of organic small molecule materials allows for mass production of high resolution RGB-OLED-displays. An infrared absorbing target is coated with the desired emitting material, which is placed in a short distance in front of an OLED substrate. A scanner deflects and focuses an infrared laser beam onto the target. By adjusting scanning speed and laser power accurately the target locally heats up to a temperature where the organic material sublimes and will be deposited on the opposite OLED substrate. By repeating this for red, green and blue emitting materials a RGB-OLED-display can be realized. For process evaluation and development a LILT-module has been built, incorporating two custom vacuum chambers, several lift and transfer stages, a high-speed high-precision scanner and an infrared continuous-wave laser (cw). This module is designed to be part of a future inline deposition system for full-color OLED displays. In the first experiments it could be observed, that the pattern resolution is strongly dependent on the scanning speed, exhibiting minimum feature sizes of 40μm. It can be deducted that this is due to the laser's beam profile (TEM00), which allows for the smallest focus possible, but may not allow for rugged process conditions suitable for production. Rectangular steep-edged beam profiles may overcome this problem.

Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity.

PubMed

Moradi, Sona; Hadjesfandiari, Narges; Toosi, Salma Fallah; Kizhakkedathu, Jayachandran N; Hatzikiriakos, Savvas G

2016-07-13

In order to design antithrombotic implants, the effect of extreme wettability (superhydrophilicity to superhydrophobicity) on the biocompatibility of the metallic substrates (stainless steel and titanium) was investigated. The wettability of the surface was altered by chemical treatments and laser ablation methods. The chemical treatments generated different functionality groups and chemical composition as evident from XPS analysis. The micro/nanopatterning by laser ablation resulted in three different pattern geometry and different surface roughness and consequently wettability. The patterned surface were further modified with chemical treatments to generate a wide range of surface wettability. The influence of chemical functional groups, pattern geometry, and surface wettability on protein adsorption and platelet adhesion was studied. On chemically treated flat surfaces, the type of hydrophilic treatment was shown to be a contributing factor that determines the platelet adhesion, since the hydrophilic oxidized substrates exhibit less platelet adhesion in comparison to the control untreated or acid treated surfaces. Also, the surface morphology, surface roughness, and superhydrophobic character of the surfaces are contributing factors to platelet adhesion on the surface. Our results show that superhydrophobic cauliflower-like patterns are highly resistant to platelet adhesion possibly due to the stability of Cassie-Baxter state for this pattern compared to others. Our results also show that simple surface treatments on metals offer a novel way to improve the hemocompatibility of metallic substrates.

Possible mechanisms for four regimes associated with cold events over East Asia

NASA Astrophysics Data System (ADS)

Yang, Zifan; Huang, Wenyu; Wang, Bin; Chen, Ruyan; Wright, Jonathon S.; Ma, Wenqian

2017-09-01

Circulation patterns associated with cold events over East Asia during the winter months of 1948-2014 are classified into four regimes by applying a k-means clustering method based on the area-weighted pattern correlation. The earliest precursor signals for two regimes are anticyclonic anomalies, which evolve into Ural and central Siberian blocking-like circulation patterns. The earliest precursor signals for the other two regimes are cyclonic anomalies, both of which evolve to amplify the East Asian trough (EAT). Both the blocking-like circulation patterns and amplified EAT favor the initialization of cold events. On average, the blocking-related regimes tend to last longer. The lead time of the earliest precursor signal for the central Siberian blocking-related regime is only 4 days, while those for the other regimes range from 16 to 18 days. The North Atlantic Oscillation plays essential roles both in triggering the precursor for the Ural blocking-related regime and in amplifying the precursors for all regimes. All regimes preferentially occur during the positive phase of the Eurasian teleconnection pattern and the negative phase of the El Niño-Southern Oscillation. For three regimes, surface cooling is primarily due to reduced downward infrared radiation and enhanced cold advection. For the remaining regime, which is associated with the southernmost cooling center, sensible and latent heat release and horizontal cold advection dominate the East Asian cooling.

Auroral E-region Plasma Irregularities and their Control by the Plasma Convection in the Southern Hemisphere

NASA Astrophysics Data System (ADS)

Forsythe, V. V.; Makarevich, R. A.

2016-12-01

Small-scale ionospheric plasma irregularities in the high-latitude E region and their control by F-region plasma convection are investigated using Super Dual Auroral Network (SuperDARN) observations at high southern latitudes over a 1-year period. Significant asymmetries are found in the velocity occurrence distribution due to the clustering of the high-velocity echoes of a particular velocity polarity. Statistical analysis of convection showed that some radars observe predominantly negative bias in the convection component within their short, E-region ranges, while others have a predominantly positive bias. A hypothesis that this bias is caused by asymmetric sectoring of the high-latitude plasma convection pattern is investigated. A new algorithm is developed that samples the plasma convection map and evaluates the convection pattern asymmetry along the particular latitude that corresponds to the radar location. It is demonstrated that the convection asymmetry has a particular seasonal and diurnal pattern, which is different for the polar and auroral radars. Possible causes for the observed convection pattern asymmetry are discussed. It is further proposed that the statistical occurrence of high-velocity E-region echoes generated by the Farley-Buneman instability (FBI) is highly sensitive to small changes in the convection pattern, which is consistent with the electric field threshold for the FBI onset being perhaps sharper and lower than previously thought.

The evolution of colour pattern complexity: selection for conspicuousness favours contrasting within-body colour combinations in lizards.

PubMed

Pérez I de Lanuza, G; Font, E

2016-05-01

Many animals display complex colour patterns that comprise several adjacent, often contrasting colour patches. Combining patches of complementary colours increases the overall conspicuousness of the complex pattern, enhancing signal detection. Therefore, selection for conspicuousness may act not only on the design of single colour patches, but also on their combination. Contrasting long- and short-wavelength colour patches are located on the ventral and lateral surfaces of many lacertid lizards. As the combination of long- and short-wavelength-based colours generates local chromatic contrast, we hypothesized that selection may favour the co-occurrence of lateral and ventral contrasting patches, resulting in complex colour patterns that maximize the overall conspicuousness of the signal. To test this hypothesis, we performed a comparative phylogenetic study using a categorical colour classification based on spectral data and descriptive information on lacertid coloration collected from the literature. Our results demonstrate that conspicuous ventral (long-wavelength-based) and lateral (short-wavelength-based) colour patches co-occur throughout the lacertid phylogeny more often than expected by chance, especially in the subfamily Lacertini. These results suggest that selection promotes the evolution of the complex pattern rather than the acquisition of a single conspicuous colour patch, possibly due to the increased conspicuousness caused by the combination of colours with contrasting spectral properties. © 2016 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2016 European Society For Evolutionary Biology.

Myocardial architecture and patient variability in clinical patterns of atrial fibrillation

NASA Astrophysics Data System (ADS)

Manani, Kishan A.; Christensen, Kim; Peters, Nicholas S.

2016-10-01

Atrial fibrillation (AF) increases the risk of stroke by a factor of 4-5 and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals and is poorly understood. An inability to understand and predict variation in AF progression has resulted in less patient-specific therapy. Likewise, it has been a challenge to relate the microstructural features of heart muscle tissue (myocardial architecture) with the emergent temporal clinical patterns of AF. We use a simple model of activation wave-front propagation on an anisotropic structure, mimicking heart muscle tissue, to show how variation in AF behavior arises naturally from microstructural differences between individuals. We show that the stochastic nature of progressive transversal uncoupling of muscle strands (e.g., due to fibrosis or gap junctional remodeling), as occurs with age, results in variability in AF episode onset time, frequency, duration, burden, and progression between individuals. This is consistent with clinical observations. The uncoupling of muscle strands can cause critical architectural patterns in the myocardium. These critical patterns anchor microreentrant wave fronts and thereby trigger AF. It is the number of local critical patterns of uncoupling as opposed to global uncoupling that determines AF progression. This insight may eventually lead to patient-specific therapy when it becomes possible to observe the cellular structure of a patient's heart.

Assessment of possible airborne impact from nuclear risk sites - Part II: probabilistic analysis of atmospheric transport patterns in Euro-Arctic region

NASA Astrophysics Data System (ADS)

Mahura, A. G.; Baklanov, A. A.

2003-10-01

The probabilistic analysis of atmospheric transport patterns from most important nuclear risk sites in the Euro-Arctic region is performed employing the methodology developed within the "Arctic Risk" Project of the NARP Programme (Baklanov and Mahura, 2003). The risk sites are the nuclear power plants in the Northwest Russia, Finland, Sweden, Lithuania, United Kingdom, and Germany as well as the Novaya Zemlya test site of Russia. The geographical regions of interest are the Northern and Central European countries and Northwest Russia. In this study, the employed research tools are the trajectory model to calculate a multiyear dataset of forward trajectories that originated over the risk site locations, and a set of statistical methods (including exploratory, cluster, and probability fields analyses) for analysis of trajectory modelling results. The probabilistic analyses of trajectory modelling results for eleven sites are presented as a set of various indicators of the risk sites possible impact on geographical regions and countries of interest. The nuclear risk site possible impact (on a particular geographical region, territory, country, site, etc.) due to atmospheric transport from the site after hypothetical accidental release of radioactivity can be properly estimated based on a combined interpretation of the indicators (simple characteristics, atmospheric transport pathways, airflow and fast transport probability fields, maximum reaching distance and maximum possible impact zone, typical transport time and precipitation factor fields) for different time periods (annual, seasonal, and monthly) for any selected site (both separately for each site or grouped for several sites) in the Euro-Arctic region. Such estimation could be the useful input information for the decision-making process, risk assessment, and planning of emergency response systems for sites of nuclear, chemical, and biological danger.

Layout compliance for triple patterning lithography: an iterative approach

NASA Astrophysics Data System (ADS)

Yu, Bei; Garreton, Gilda; Pan, David Z.

2014-10-01

As the semiconductor process further scales down, the industry encounters many lithography-related issues. In the 14nm logic node and beyond, triple patterning lithography (TPL) is one of the most promising techniques for Metal1 layer and possibly Via0 layer. As one of the most challenging problems in TPL, recently layout decomposition efforts have received more attention from both industry and academia. Ideally the decomposer should point out locations in the layout that are not triple patterning decomposable and therefore manual intervention by designers is required. A traditional decomposition flow would be an iterative process, where each iteration consists of an automatic layout decomposition step and manual layout modification task. However, due to the NP-hardness of triple patterning layout decomposition, automatic full chip level layout decomposition requires long computational time and therefore design closure issues continue to linger around in the traditional flow. Challenged by this issue, we present a novel incremental layout decomposition framework to facilitate accelerated iterative decomposition. In the first iteration, our decomposer not only points out all conflicts, but also provides the suggestions to fix them. After the layout modification, instead of solving the full chip problem from scratch, our decomposer can provide a quick solution for a selected portion of layout. We believe this framework is efficient, in terms of performance and designer friendly.

The morphology and classification of α ganglion cells in the rat retinae: a fractal analysis study.

PubMed

Jelinek, Herbert F; Ristanović, Dušan; Milošević, Nebojša T

2011-09-30

Rat retinal ganglion cells have been proposed to consist of a varying number of subtypes. Dendritic morphology is an essential aspect of classification and a necessary step toward understanding structure-function relationships of retinal ganglion cells. This study aimed at using a heuristic classification procedure in combination with the box-counting analysis to classify the alpha ganglion cells in the rat retinae based on the dendritic branching pattern and to investigate morphological changes with retinal eccentricity. The cells could be divided into two groups: cells with simple dendritic pattern (box dimension lower than 1.390) and cells with complex dendritic pattern (box dimension higher than 1.390) according to their dendritic branching pattern complexity. Both were further divided into two subtypes due to the stratification within the inner plexiform layer. In the present study we have shown that the alpha rat RCGs can be classified further by their dendritic branching complexity and thus extend those of previous reports that fractal analysis can be successfully used in neuronal classification, particularly that the fractal dimension represents a robust and sensitive tool for the classification of retinal ganglion cells. A hypothesis of possible functional significance of our classification scheme is also discussed. Copyright © 2011 Elsevier B.V. All rights reserved.

Marital stability and cancer of the uterine cervix: changing patterns in post-war Britain.

PubMed

Murphy, M F; Goldblatt, P O; Mant, D

1993-06-01

This study investigates the extent to which the distinctive cross-sectional marital status picture of risk for cancer of the uterine cervix (single, married, widowed, divorced in ascending order of risk) has persisted in post-war Britain. Incidence and mortality due to invasive cervical cancer amongst single women now exceeds that of the married, and for both has become much closer to that of the widowed and divorced. A dramatic increase in carcinoma in situ in Scotland, seen particularly in the single since 1982, must partly reflect changes in screening and diagnostic classification, but is also consistent with the later occurrence of the sexual revolution in Scotland. Overall in Britain, the distribution of screening and hysterectomy cannot account for the present day pattern of the disease. Available data on patterns of smoking and oral contraceptive use are broadly consistent with a role for them in determining the current disease pattern associated with marital status but their possible involvement cannot be disentangled from the more likely effect of changing levels of sexual activity increasing the risk of sexually transmitted disease. As marital status becomes a less important social indicator of sexual behaviour, it has also become a much less reliable marker of cervical cancer risk.

Understanding the spatiotemporal pattern of grazing cattle movement

NASA Astrophysics Data System (ADS)

Zhao, Kun; Jurdak, Raja

2016-08-01

Understanding the drivers of animal movement is significant for ecology and biology. Yet researchers have so far been unable to fully understand these drivers, largely due to low data resolution. In this study, we analyse a high-frequency movement dataset for a group of grazing cattle and investigate their spatiotemporal patterns using a simple two-state ‘stop-and-move’ mobility model. We find that the dispersal kernel in the moving state is best described by a mixture exponential distribution, indicating the hierarchical nature of the movement. On the other hand, the waiting time appears to be scale-invariant below a certain cut-off and is best described by a truncated power-law distribution, suggesting that the non-moving state is governed by time-varying dynamics. We explore possible explanations for the observed phenomena, covering factors that can play a role in the generation of mobility patterns, such as the context of grazing environment, the intrinsic decision-making mechanism or the energy status of different activities. In particular, we propose a new hypothesis that the underlying movement pattern can be attributed to the most probable observable energy status under the maximum entropy configuration. These results are not only valuable for modelling cattle movement but also provide new insights for understanding the underlying biological basis of grazing behaviour.

Is killer whale dialect evolution random?

PubMed

Filatova, Olga A; Burdin, Alexandr M; Hoyt, Erich

2013-10-01

The killer whale is among the few species in which cultural change accumulates over many generations, leading to cumulative cultural evolution. Killer whales have group-specific vocal repertoires which are thought to be learned rather than being genetically coded. It is supposed that divergence between vocal repertoires of sister groups increases gradually over time due to random learning mistakes and innovations. In this case, the similarity of calls across groups must be correlated with pod relatedness and, consequently, with each other. In this study we tested this prediction by comparing the patterns of call similarity between matrilines of resident killer whales from Eastern Kamchatka. We calculated the similarity of seven components from three call types across 14 matrilines. In contrast to the theoretical predictions, matrilines formed different clusters on the dendrograms made by different calls and even by different components of the same call. We suggest three possible explanations for this phenomenon. First, the lack of agreement between similarity patterns of different components may be the result of constraints in the call structure. Second, it is possible that call components change in time with different speed and/or in different directions. Third, horizontal cultural transmission of call features may occur between matrilines. Copyright © 2013 Elsevier B.V. All rights reserved.

Phylogeography and population genetic structure of double-crested cormorants (Phalacrocorax auritus)

USGS Publications Warehouse

Mercer, Dacey; Haig, Susan M.; Roby, Daniel D.

2013-01-01

is genetically divergent from other populations in North America (net sequence divergence = 5.85 %;UST for mitochondrial control region = 0.708; FST for microsatellite loci = 0.052). Historical records, contemporary population estimates, and field observations are consistent with recognition of the Alaskan subspecies as distinct and potentially of conservation interest. Our data also indicated the presence of another divergent lineage, associated with the southwestern portion of the species range, as evidenced by highly unique haplotypes sampled in southern California. In contrast, there was little support for recognition of subspecies within the conterminous U.S. and Canada. Rather than genetically distinct regions corresponding to the putative subspecies [P. a. albociliatus (Pacific), P. a. auritus (Interior and North Atlantic), and P. a. floridanus (Southeast)], we observed a distribution of genetic variation consistent with a pattern of isolation by distance. This pattern implies that genetic differences across the range are due to geographic distance, rather than discrete subspecific breaks. Although three of the four traditional subspecies were not genetically distinct, possible demographic separation, habitat differences, and documented declines at some colonies within the regions, suggests that the Pacific and possibly North Atlantic portions of the breeding range may warrant differential consideration from the Interior and Southeast breeding regions.

Using Polynomials to Simplify Fixed Pattern Noise and Photometric Correction of Logarithmic CMOS Image Sensors

PubMed Central

Li, Jing; Mahmoodi, Alireza; Joseph, Dileepan

2015-01-01

An important class of complementary metal-oxide-semiconductor (CMOS) image sensors are those where pixel responses are monotonic nonlinear functions of light stimuli. This class includes various logarithmic architectures, which are easily capable of wide dynamic range imaging, at video rates, but which are vulnerable to image quality issues. To minimize fixed pattern noise (FPN) and maximize photometric accuracy, pixel responses must be calibrated and corrected due to mismatch and process variation during fabrication. Unlike literature approaches, which employ circuit-based models of varying complexity, this paper introduces a novel approach based on low-degree polynomials. Although each pixel may have a highly nonlinear response, an approximately-linear FPN calibration is possible by exploiting the monotonic nature of imaging. Moreover, FPN correction requires only arithmetic, and an optimal fixed-point implementation is readily derived, subject to a user-specified number of bits per pixel. Using a monotonic spline, involving cubic polynomials, photometric calibration is also possible without a circuit-based model, and fixed-point photometric correction requires only a look-up table. The approach is experimentally validated with a logarithmic CMOS image sensor and is compared to a leading approach from the literature. The novel approach proves effective and efficient. PMID:26501287

Engineering multiple topological phases in nanoscale Van der Waals heterostructures: realisation of α-antimonene

NASA Astrophysics Data System (ADS)

Märkl, T.; Kowalczyk, P. J.; Le Ster, M.; Mahajan, I. V.; Pirie, H.; Ahmed, Z.; Bian, G.; Wang, X.; Chiang, T.-C.; Brown, S. A.

2018-01-01

Van der Waals heterostructures have recently been identified as providing many opportunities to create new two-dimensional materials, and in particular to produce materials with topologically-interesting states. Here we show that it is possible to create such heterostructures with multiple topological phases in a single nanoscale island. We discuss their growth within the framework of diffusion-limited aggregation, the formation of moiré patterns due to the differing crystallographies of the materials comprising the heterostructure, and the potential to engineer both the electronic structure as well as local variations of topological order. In particular we show that it is possible to build islands which include both the hexagonal β- and rectangular α-forms of antimonene, on top of the topological insulator α-bismuthene. This is the first experimental realisation of α-antimonene, and we show that it is a topologically non-trivial material in the quantum spin Hall class.

Enhanced ferroelectric polarization and possible morphotrophic phase boundary in PZT-based alloys

DOE PAGES

Parker, David S.; Singh, David; McGuire, Michael A.; ...

2016-05-16

We present a combined theoretical and experimental study of alloys of the high performance piezoelectric PZT (PbZr 0.5Ti 0.5O 3) with BZnT (BiZn 0.5Ti 0.5O 3) and BZnZr (BiZn 0.5Zr 0.5O 3), focusing on atomic displacements, ferroelectric polarization, and elastic stability. From theory we find that the 75-25 PZT-BZnT alloy has substantially larger cation displacements, and hence ferroelectric polarization than the PZT base material, on the tetragonal side of the phase diagram. We also find a possible morphotrophic phase boundary in this system by comparing displacement patterns and optimized c/a ratios. Elastic stability calculations find the structures to be essentiallymore » stable. Lastly, experiments indicate the feasibility of sample synthesis within this alloy system, although measurements do not find significant polarization, probably due to a large coercive field.« less

Polymeric Micelles and Alternative Nanonized Delivery Vehicles for Poorly Soluble Drugs

PubMed Central

Lu, Ying; Park, Kinam

2013-01-01

Poorly soluble drugs often encounter low bioavailability and erratic absorption patterns in the clinical setting. Due to the rising number of compounds having solubility issues, finding ways to enhance the solubility of drugs is one of the major challenges in the pharmaceutical industry today. Polymeric micelles, which form upon self-assembly of amphiphilic macromolecules, can act as solubilizing agents for delivery of poorly soluble drugs. This manuscript examines the fundamentals of polymeric micelles through reviews of representative literature and demonstrates possible applications through recent examples of clinical trial developments. In particular, the potential of polymeric micelles for delivery of poorly water-soluble drugs, especially in the areas of oral delivery and in cancer therapy, is discussed. Key considerations in utilizing polymeric micelles’ advantages and overcoming potential disadvantages have been highlighted. Lastly, other possible strategies related to particle size reduction for enhancing solubilization of poorly water-soluble drugs are introduced. PMID:22944304

Qualitative and semiquantitative Fourier transformation using a noncoherent system.

PubMed

Rogers, G L

1979-09-15

A number of authors have pointed out that a system of zone plates combined with a diffuse source, transparent input, lens, and focusing screen will display on the output screen the Fourier transform of the input. Strictly speaking, the transform normally displayed is the cosine transform, and the bipolar output is superimposed on a dc gray level to give a positive-only intensity variation. By phase-shifting one zone plate the sine transform is obtained. Temporal modulation is possible. It is also possible to redesign the system to accept a diffusely reflecting input at the cost of introducing a phase gradient in the output. Results are given of the sine and cosine transforms of a small circular aperture. As expected, the sine transform is a uniform gray. Both transforms show unwanted artifacts beyond 0.1 rad off-axis. An analysis shows this is due to unwanted circularly symmetrical moire patterns between the zone plates.

Validity of the Rapid Eating Assessment for Patients for assessing dietary patterns in NCAA athletes.

PubMed

Kurka, Jonathan M; Buman, Matthew P; Ainsworth, Barbara E

2014-01-01

Athletes may be at risk for developing adverse health outcomes due to poor eating behaviors during college. Due to the complex nature of the diet, it is difficult to include or exclude individual food items and specific food groups from the diet. Eating behaviors may better characterize the complex interactions between individual food items and specific food groups. The purpose was to examine the Rapid Eating Assessment for Patients survey (REAP) as a valid tool for analyzing eating behaviors of NCAA Division-I male and female athletes using pattern identification. Also, to investigate the relationships between derived eating behavior patterns and body mass index (BMI) and waist circumference (WC) while stratifying by sex and aesthetic nature of the sport. Two independent samples of male (n = 86; n = 139) and female (n = 64; n = 102) collegiate athletes completed the REAP in June-August 2011 (n = 150) and June-August 2012 (n = 241). Principal component analysis (PCA) determined possible factors using wave-1 athletes. Exploratory (EFA) and confirmatory factor analyses (CFA) determined factors accounting for error and confirmed model fit in wave-2 athletes. Wave-2 athletes' BMI and WC were recorded during a physical exam and sport participation determined classification in aesthetic and non-aesthetic sport. Mean differences in eating behavior pattern score were explored. Regression models examined interactions between pattern scores, participation in aesthetic or non-aesthetic sport, and BMI and waist circumference controlling for age and race. A 5-factor PCA solution accounting for 60.3% of sample variance determined fourteen questions for EFA and CFA. A confirmed solution revealed patterns of Desserts, Healthy food, Meats, High-fat food, and Dairy. Pattern score (mean ± SE) differences were found, as non-aesthetic sport males had a higher (better) Dessert score than aesthetic sport males (2.16 ± 0.07 vs. 1.93 ± 0.11). Female aesthetic athletes had a higher score compared to non-aesthetic female athletes for the Dessert (2.11 ± 0.11 vs. 1.88 ± 0.08), Meat (1.95 ± 0.10 vs. 1.72 ± 0.07), High-fat food (1.70 ± 0.08 vs. 1.46 ± 0.06), and Dairy (1.70 ± 0.11 vs. 1.43 ± 0.07) patterns. REAP is a construct valid tool to assess dietary patterns in college athletes. In light of varying dietary patterns, college athletes should be evaluated for healthful and unhealthful eating behaviors.

Chlorinated paraffin analysis by gas chromatography Orbitrap high-resolution mass spectrometry: Method performance, investigation of possible interferences and analysis of fish samples.

PubMed

Krätschmer, Kerstin; Cojocariu, Cristian; Schächtele, Alexander; Malisch, Rainer; Vetter, Walter

2018-03-02

For decades, high quantities of short-chain chlorinated paraffins (SCCP) and medium-chain chlorinated paraffins (MCCP) have been widely used, for instance as plasticizers or flame retardants, leading to global pollution due to unintentional emissions from products or waste. Due to the high complexity of chlorinated paraffins with several thousand congeners there is no consensus on an analytical procedure for SCCPs and MCCPs in food samples. Amongst the multitude of methods currently in use, high-resolution mass spectrometry is particularly valuable for in-depth studies of homologue patterns. Here we analyse SCCPs and MCCPs with gas chromatography coupled to high-resolution Orbitrap mass spectrometry (GC-Orbitrap-HRMS) operated in full-scan acquisition in electron capture negative ion (ECNI) mode at 60,000 and 120,000 resolution (FWHM, m/z 200, equals roughly 30,000 and 60,000 at 5% peak height). Linear dynamic range, selectivity and sensitivity tests confirmed an excellent linearity in a concentration range of 25-15,000 pg/μL with very low limits of detection (LODs) in the low pg/μL range. Spiking experiments with high levels of native mono- and di-ortho-polychlorinated biphenyls (PCBs) and mixtures of MCCP and SCCP standards did not have a negative impact on isotope ratios of the examined homologues. Besides the [M-Cl] - fragment ions used for quantification, the mass spectra of homologues also featured [M-HCl] - ions whose abundance increased with decreasing chlorination degree. In addition, [M-HCl-Cl] - ions were detected with a relative abundance of 5-10%. Three salmon (Salmo salar) samples farmed in Norway showed a consistent CP homologue pattern which differed both from the CP pattern in a sample from Scottish aquaculture and a wild salmon sample. These measurements produce evidence that discretely different CP patterns may exist in different areas of origin. Our results demonstrate that GC/ECNI-Orbitrap-HRMS is well-suited for the analysis of CPs by overcoming a range of mass interference problems and due to its thus far unmatched sensitivity. Copyright © 2018 Elsevier B.V. All rights reserved.

Influence of land use and climate on Salmonella carrier status in the small Indian mongoose (Herpestes auropunctatus) in Grenada, West Indies.

PubMed

Miller, Steven; Zieger, Ulrike; Ganser, Claudia; Satterlee, S Andrew; Bankovich, Brittany; Amadi, Victor; Hariharan, Harry; Stone, Diana; Wisely, Samantha M

2015-01-01

Invasive mammals can be important reservoirs for human pathogens. A recent study showed that 12% of mongooses carried Salmonella spp. in their large intestines. We investigated whether anthropogenic, environmental and climatic variables predicted Salmonella status in mongooses (Herpestes auropunctatus) in Grenada. Using multivariate logistic regression and contingency table analysis, we found that increased human density, decreased distance from roads, and low monthly precipitation were associated with increased probability of Salmonella carriage. Areas with higher human density likely support a higher abundance of mongooses because of greater food availability. These areas also are a likely source for infection to mongooses due to high densities of livestock and rodents shedding Salmonella. The higher probability of Salmonella carriage in mongooses during drier months and closer to roadsides is likely due to water drainage patterns and limited water availability. Although the overall prevalence of Salmonella in mongooses was moderate, the strong patterns of ecologic correlates, combined with the high density of mongooses throughout Grenada suggest that the small Indian mongoose could be a useful sentinel for Salmonella surveillance. Its affinity for human-associated habitats suggests that the small Indian mongoose is also a risk factor in the maintenance and possible spread of Salmonella species to humans and livestock in Grenada.

Constraining Alternative Theories of Gravity Using Pulsar Timing Arrays

NASA Astrophysics Data System (ADS)

Cornish, Neil J.; O'Beirne, Logan; Taylor, Stephen R.; Yunes, Nicolás

2018-05-01

The opening of the gravitational wave window by ground-based laser interferometers has made possible many new tests of gravity, including the first constraints on polarization. It is hoped that, within the next decade, pulsar timing will extend the window by making the first detections in the nanohertz frequency regime. Pulsar timing offers several advantages over ground-based interferometers for constraining the polarization of gravitational waves due to the many projections of the polarization pattern provided by the different lines of sight to the pulsars, and the enhanced response to longitudinal polarizations. Here, we show that existing results from pulsar timing arrays can be used to place stringent limits on the energy density of longitudinal stochastic gravitational waves. However, unambiguously distinguishing these modes from noise will be very difficult due to the large variances in the pulsar-pulsar correlation patterns. Existing upper limits on the power spectrum of pulsar timing residuals imply that the amplitude of vector longitudinal (VL) and scalar longitudinal (SL) modes at frequencies of 1/year are constrained, AVL<4 ×10-16 and ASL<4 ×10-17, while the bounds on the energy density for a scale invariant cosmological background are ΩVLh2<4 ×10-11 and ΩSLh2<3 ×10-13.

Human norovirus infection in Latin America.

PubMed

da Silva Poló, Tatiane; Peiró, Juliana R; Mendes, Luiz Cláudio Nogueira; Ludwig, Louisa F; de Oliveira-Filho, Edmilson F; Bucardo, Filemon; Huynen, Pascale; Melin, Pierrette; Thiry, Etienne; Mauroy, Axel

2016-05-01

Noroviruses are important enteric pathogens involved in non-bacterial gastroenteritis outbreaks worldwide. Noroviruses mainly occur from person to person via the fecal-oral route but also through contaminated food or water; indirect contamination is also possible due to the resistance of the virus in the environment. Latin American countries as a whole cover a vast North-to-South range, which is highly heterogeneous in terms of climate, ecosystem, human population distribution (urban areas with high human densities versus closed communities), economic development and genetic backgrounds resulting from each particular historical context. This review aims to present epidemiological and clinical patterns of human norovirus infections in Latin American countries. Divergent prevalences were observed depending on the country and the surveyed population. In particular, a shift in rotavirus/norovirus ratio in the etiologies of gastroenteritis was detected in some countries and could be attributed partly to rotavirus vaccine coverage in their infant population. While GII.4 noroviruses were seen to constitute the most common genotype, differences in genotype distribution were observed both in the environment (via sewage sampling proxy) and between genotypes circulating in healthy and diarrheic patients. Due to high climatic discrepancies, different patterns of seasonality were observed. Accordingly, this continent may condense the different particular epidemiological features encountered for HuNoV infections worldwide. Copyright © 2016 Elsevier B.V. All rights reserved.

Constraining Alternative Theories of Gravity Using Pulsar Timing Arrays.

PubMed

Cornish, Neil J; O'Beirne, Logan; Taylor, Stephen R; Yunes, Nicolás

2018-05-04

The opening of the gravitational wave window by ground-based laser interferometers has made possible many new tests of gravity, including the first constraints on polarization. It is hoped that, within the next decade, pulsar timing will extend the window by making the first detections in the nanohertz frequency regime. Pulsar timing offers several advantages over ground-based interferometers for constraining the polarization of gravitational waves due to the many projections of the polarization pattern provided by the different lines of sight to the pulsars, and the enhanced response to longitudinal polarizations. Here, we show that existing results from pulsar timing arrays can be used to place stringent limits on the energy density of longitudinal stochastic gravitational waves. However, unambiguously distinguishing these modes from noise will be very difficult due to the large variances in the pulsar-pulsar correlation patterns. Existing upper limits on the power spectrum of pulsar timing residuals imply that the amplitude of vector longitudinal (VL) and scalar longitudinal (SL) modes at frequencies of 1/year are constrained, A_{VL}<4×10^{-16} and A_{SL}<4×10^{-17}, while the bounds on the energy density for a scale invariant cosmological background are Ω_{VL}h^{2}<4×10^{-11} and Ω_{SL}h^{2}<3×10^{-13}.

Epigenetic variants of a transgenic petunia line show hypermethylation in transgene DNA: an indication for specific recognition of foreign DNA in transgenic plants.

PubMed

Meyer, P; Heidmann, I

1994-05-25

We analysed de novo DNA methylation occurring in plants obtained from the transgenic petunia line R101-17. This line contains one copy of the maize A1 gene that leads to the production of brick-red pelargonidin pigment in the flowers. Due to its integration into an unmethylated genomic region the A1 transgene is hypomethylated and transcriptionally active. Several epigenetic variants of line 17 were selected that exhibit characteristic and somatically stable pigmentation patterns, displaying fully coloured, marbled or colourless flowers. Analysis of the DNA methylation patterns revealed that the decrease in pigmentation among the epigenetic variants was correlated with an increase in methylation, specifically of the transgene DNA. No change in methylation of the hypomethylated integration region could be detected. A similar increase in methylation, specifically in the transgene region, was also observed among progeny of R101-17del, a deletion derivative of R101-17 that no longer produces pelargonidin pigments due to a deletion in the A1 coding region. Again de novo methylation is specifically directed to the transgene, while the hypomethylated character of neighbouring regions is not affected. Possible mechanisms for transgene-specific methylation and its consequences for long-term use of transgenic material are discussed.

A new index for the quantification of chromosome number variation: an application to selected animal and plant groups.

PubMed

Peruzzi, Lorenzo; Caparelli, Katia Francesca; Bedini, Gianni

2014-07-21

Quantitative parameters have been used to characterize chromosome number (CN) variation. This gave us the idea to collect available data in various organisms and compare them, in order to verify if variation patterns differ between animal and plant groups and to quantify these patterns with an Index of CN Heterogeneity (ICNH), useful as a parameter to compare related taxonomical/geographical groups of organisms. To the best of our knowledge, this is the first attempt to compare CN variation in animal and plant groups with large datasets. The quantitative analysis allowed detecting significant differences among most groups of animals and plants. The most striking difference, however, is the close relationship between mean CN and SD restricted to plants, in which higher CN are also associated with a larger variation degree, possibly due to the well known genomic plasticity in this group and a propensity for polyploidization higher than in animals. The ICNH defined here can be easily calculated for both animal and plant groups based on commonly available data. It summarizes data accumulated in over a century of research and includes so-called anomalies like fB and fOCN, sometimes overlooked by researchers due to lack of a proper way of comparison. Copyright © 2014 Elsevier Ltd. All rights reserved.

[Dietary patterns and metabolic syndrome components in women with excess weight 18 to 45 years old].

PubMed

Hernández-Ruiz, Zugey; Rodríguez-Ramírez, Sonia; Hernández-Cordero, Sonia; Monterrubio-Flores, Eric

2018-01-01

To analyze the association between dietary patterns and metabolic syndrome (MS) components in adult women with excess weight. Cross-sectional study with anthropometric, dietary, biochemical and blood pressure data. Dietary patterns were identified by factor analysis and multiple logistic regression models were used to analyze associations. The prevalence of altered glucose was 14.6%, of hypertriglyceridemia 40.4%, of altered concentration of high density lipoprotein cholesterol(HDLc) 45.0%, hypertension 4.6% and MS 30%. The pattern with high consumption of corn tortillas, meats and legumes, was associated with less possibility of hyperglycemia (OR= 0.62; 95%CI 0.39-0.98). The pattern with high consumption of sweet and salty snacks, milk, rice, soaps and pasta, was inversely associated with the possibility of low HDLc concentration (OR= 0.76; 95%CI 0.60-0.97). A dietary pattern with greater consumption of legumes, meats and corn tortillas was associated with less possibility of having hyperglycemia.

Pn-waves Travel-time Anomaly beneath Taiwan from Dense Seismic Array Observations and its Possible Tectonic Implications

NASA Astrophysics Data System (ADS)

Lin, Y. Y.; Huang, B. S.; Ma, K. F.; Hsieh, M. C.

2015-12-01

We investigated travel times of Pn waves, which are of great important for understanding the Moho structure in Taiwan region. Although several high quality tomographic studies had been carried out, observations of Pn waves are still the most comprehensive way to elucidate the Moho structure. Mapping the Moho structure of Taiwan had been a challenging due to the small spatial dimension of Taiwan island with two subduction systems. To decipher the tectonic structure and understanding of earthquake hazard, the island of Taiwan have been implemented by several high density seismic stations, including 71 short-period stations of Central Weather Bureau Seismic Network (CWBSN) and 42 broardband stations of Broadband Array in Taiwan for Seismology (BATS). High quality seismic records of these stations would be used to identify precise Pn-wave arrival times. After station-elevation correction, we measure the difference between the observed and theoretical Pn arrivals from the IASPI 91 model for each station. For correcting uncertainties of earthquake location and origin time, we estimate relative Pn anomaly, ΔtPn , between each station and a reference station. The pattern of ΔtPn reflects the depth anomaly of Moho beneath Taiwan. In general, Pn waves are commonly observed from shallow earthquake at epicentral distance larger than 120 km. We search the global catalog since 2005 and the criteria are M > 5.5, focal depth < 30 km and epicentral distance > 150 km. The 12 medium earthquakes from north Luzon are considered for analysis. We choose a station, TWKB, in the most southern point of Taiwan as the reference station due to that all events are from the south. The results indicate obvious different patterns of ΔtPn from different back-azimuths. The ΔtPn pattern of the events in the first group from the south south-east indicates that the Pn arrivals delay suddenly when the Pn waves pass through the Central Range, suggesting the Moho becomes deep rapidly. However, we cannot recognize the same pattern when the events from due south in the second group. The ΔtPn pattern in the second group has a clear slow gradient from the south to north through Taiwan island. It may be relative to a smooth dipping structure of the Moho. Both ΔtPn patterns reveal large delays in northern Taiwan which may be related to the north subduction structure.

The possible effects of the solar and geomagnetic activity on multiple sclerosis.

PubMed

Papathanasopoulos, Panagiotis; Preka-Papadema, Panagiota; Gkotsinas, Anastasios; Dimisianos, Nikolaos; Hillaris, Alexandros; Katsavrias, Christos; Antonakopoulos, Gregorios; Moussas, Xenophon; Andreadou, Elisabeth; Georgiou, Vasileios; Papachristou, Pinelopi; Kargiotis, Odysseas

2016-07-01

Increasing observational evidence on the biological effects of Space Weather suggests that geomagnetic disturbances may be an environmental risk factor for multiple sclerosis (MS) relapses. In the present study, we aim to investigate the possible effect of geomagnetic disturbances on MS activity. MS patient admittance rates were correlated with the solar and geophysical data covering an eleven-year period (1996-2006, 23rd solar cycle). We also examined the relationship of patterns of the solar flares, the coronal mass ejections (CMEs) and the solar wind with the recorded MS admission numbers. The rate of MS patient admittance due to acute relapses was found to be associated with the solar and geomagnetic events. There was a "primary" peak in MS admittance rates shortly after intense geomagnetic storms followed by a "secondary" peak 7-8 months later. We conclude that the geomagnetic and solar activity may represent an environmental health risk factor for multiple sclerosis and we discuss the possible mechanisms underlying this association. More data from larger case series are needed to confirm these preliminary results and to explore the possible influence of Space Weather on the biological and radiological markers of the disease. Copyright © 2016 Elsevier B.V. All rights reserved.

Surgical techniques for the treatment of carpal ligament injury in the athlete.

PubMed

Paci, Gabrielle M; Yao, Jeffrey

2015-01-01

Treatment of intercarpal ligament injuries in the athlete requires special attention due to several practical and biomechanical considerations. Optimally, the athlete will maintain as much function and range of motion as possible with return to high-impact and load-bearing activity in a timely fashion. Several cutting-edge techniques have arisen in treatment. This article discusses injury patterns in the athlete with scapholunate injury, lunotriquetral injury, scaphotrapezial-trapezoidal injury, and extrinsic ligamentous injury, and the various approaches to addressing these injuries, with a review of the classic as well as newer, innovative techniques. Copyright © 2015 Elsevier Inc. All rights reserved.

Nuclear chemistry of returned lunar samples: Nuclide analysis by gamma-ray spectrometry

NASA Technical Reports Server (NTRS)

Okelley, G. D.

1975-01-01

Primordial and cosmogenic radionuclide concentrations are determined nondestructively by gamma-ray spectrometry in soil and rock samples from the returned Apollo 17 sample collection from Taurus-Littrow and Descartes. Geochemical evidence in support of field geology speculation concerning layering of the subfloor basalt flows is demonstrated along with a possible correlation of magmatic fractionation of K/U as a function of depth. The pattern of radionuclide concentrations observed in these samples is distinct due to proton bombardment by the intense solar flares of August 4-9, 1972. Such radionuclide determinations are used in determining lunar sample orientation and characterizing solar flare activity.

Seismic anisotropy and mantle flow in the Hellenic subduction zone: The possible effects of trench retreat and slab tear at both ends.

NASA Astrophysics Data System (ADS)

Evangelidis, Christos

2017-04-01

The upper mantle anisotropy pattern in the entire area of the Hellenic subduction zone have been analyzed for fast polarization directions and delay times to investigate the complex 3D pattern of mantle flow around the subducting slab. All previous studies do incorporate a significant number of measurements in the backarc area of the Aegean and in two cross-sections along the Hellenic subduction system. However, the transitional area from oceanic to continental subduction in the Western Hellenic trench has not been adequately sampled so far. Moreover, the eastern termination of the Hellenic subduction and the possible origin of a trench parallel anisotropy remains unclear. Here, I focus on the two possible ends of the high curvature Hellenic arc. I have now measured SKS splitting parameters from all broadband stations of the Hellenic Unified Seismic Network (HUSN), that they have not been measured before, specially concentrated in the transitional area from oceanic to continental subduction system. Complementary, using the Source-Side splitting technique to teleseismic S-wave records from intermediate depth earthquake in the Hellenic trench, the anisotropy measurements are increased in regions where no stations are installed. In western Greece, the Hellenic subduction system is separated by the Cephalonia Transform Fault (CTF), a dextral offset of 100 km, into the northern and southern segments, which are characterized by different convergence rates and slab composition. Recent seismic data show that north of CTF there is a subducted continental lithosphere in contrast to the region south of CTF where the on-going subduction is oceanic. The new measurements, combined with previously published observations, provide the most complete up-to-date spatial coverage for the area. Generally, the pronounced zonation of seismic anisotropy across the subduction zone, as inferred from other studies, is also observed here. Fast SKS splitting directions are trench-normal in the region nearest to the trench. The fast splitting directions change abruptly to trench-parallel above the corner of the mantle wedge and rotate back to trench-normal over the back-arc. Additionally, beneath western Greece, between the western Gulf of Corinth in the south and the Epirus-Thessaly area in the north, a transitional anisotropy pattern emerges that possibly depicts the passage from the continental to the oceanic subducted slabs and the subslab mantle flow due to the trench retreat. At the eastern side of the Hellenic arc, from eastern Crete to the Dodecanese Islands, the inferred subslab measurements of anisotropy show a general trench perpendicular pattern. This area is characterized as a STEP fault region with multiple trench normal strike slip faults. The difference between the fast roll-back in the Aegean and the slow lithospheric processes in the western Anatolia is accommodated by a broad shear zone of lithospheric deformation and a possible slab tear inferred from seismic tomography and geophysical studies but with a relative unknown geometry. Thus, the observed anisotropy pattern possibly resembles the 3D return flow around the slab edge that is caused by the inferred slab break.

The impact of shoulder abduction loading on EMG-based intention detection of hand opening and closing after stroke.

PubMed

Lan, Yiyun; Yao, Jun; Dewald, Julius P A

2011-01-01

Many stroke patients are subject to limited hand functions in the paretic arm due to a significant loss of Corticospinal Tract (CST) fibers. A possible solution for this problem is to classify surface Electromyography (EMG) signals generated by hand movements and uses that to implement Functional Electrical Stimulation (FES). However, EMG usually presents an abnormal muscle coactivation pattern shown as increased coupling between muscles within and/or across joints after stroke. The resulting Abnormal Muscle Synergies (AMS) could make the classification more difficult in individuals with stroke, especially when attempting to use the hand together with other joints in the paretic arm. Therefore, this study is aimed at identifying the impact of AMS following stroke on EMG pattern recognition between two hand movements. In an effort to achieve this goal, 7 chronic hemiparetic chronic stroke subjects were recruited and asked to perform hand opening and closing movements at their paretic arm while being either fully supported by a virtual table or loaded with 25% of subject's maximum shoulder abduction force. During the execution of motor tasks EMG signals from the wrist flexors and extensors were simultaneously acquired. Our results showed that increased synergy-induced activity at elbow flexors, induced by increasing shoulder abduction loading, deteriorated the performance of EMG pattern recognition for hand opening for those with a weak grasp strength and EMG activity. However, no such impact on hand closing has yet been observed possibly because finger/wrist flexion is facilitated by the shoulder abduction-induced flexion synergy.

Transmission X-ray scattering as a probe for complex liquid-surface structures

DOE PAGES

Fukuto, Masafumi; Yang, Lin; Nykypanchuk, Dmytro; ...

2016-01-28

The need for functional materials calls for increasing complexity in self-assembly systems. As a result, the ability to probe both local structure and heterogeneities, such as phase-coexistence and domain morphologies, has become increasingly important to controlling self-assembly processes, including those at liquid surfaces. The traditional X-ray scattering methods for liquid surfaces, such as specular reflectivity and grazing-incidence diffraction, are not well suited to spatially resolving lateral heterogeneities due to large illuminated footprint. A possible alternative approach is to use scanning transmission X-ray scattering to simultaneously probe local intermolecular structures and heterogeneous domain morphologies on liquid surfaces. To test the feasibilitymore » of this approach, transmission small- and wide-angle X-ray scattering (TSAXS/TWAXS) studies of Langmuir films formed on water meniscus against a vertically immersed hydrophilic Si substrate were recently carried out. First-order diffraction rings were observed in TSAXS patterns from a monolayer of hexagonally packed gold nanoparticles and in TWAXS patterns from a monolayer of fluorinated fatty acids, both as a Langmuir monolayer on water meniscus and as a Langmuir–Blodgett monolayer on the substrate. The patterns taken at multiple spots have been analyzed to extract the shape of the meniscus surface and the ordered-monolayer coverage as a function of spot position. These results, together with continual improvement in the brightness and spot size of X-ray beams available at synchrotron facilities, support the possibility of using scanning-probe TSAXS/TWAXS to characterize heterogeneous structures at liquid surfaces.« less

An efficient way of layout processing based on calibre DRC and pattern matching for defects inspection application

NASA Astrophysics Data System (ADS)

Li, Helen; Lee, Robben; Lee, Tyzy; Xue, Teddy; Liu, Hermes; Wu, Hall; Wan, Qijian; Du, Chunshan; Hu, Xinyi; Liu, Zhengfang

2018-03-01

As technology advances, escalating layout design complexity and chip size make defect inspection becomes more challenging than ever before. The YE (Yield Enhancement) engineers are seeking for an efficient strategy to ensure accuracy without suffering running time. A smart way is to set different resolutions for different pattern structures, for examples, logic pattern areas have a higher scan resolution while the dummy areas have a lower resolution, SRAM area may have another different resolution. This can significantly reduce the scan processing time meanwhile the accuracy does not suffer. Due to the limitation of the inspection equipment, the layout must be processed in order to output the Care Area marker in line with the requirement of the equipment, for instance, the marker shapes must be rectangle and the number of the rectangle shapes should be as small as possible. The challenge is how to select the different Care Areas by pattern structures, merge the areas efficiently and then partition them into pieces of rectangle shapes. This paper presents a solution based on Calibre DRC and Pattern Matching. Calibre equation-based DRC is a powerful layout processing engine and Calibre Pattern Matching's automated visual capture capability enables designers to define these geometries as layout patterns and store them in libraries which can be re-used in multiple design layouts. Pattern Matching simplifies the description of very complex relationships between pattern shapes efficiently and accurately. Pattern matching's true power is on display when it is integrated with normal DRC deck. In this application of defects inspection, we first run Calibre DRC to get rule based Care Area then use Calibre Pattern Matching's automated pattern capture capability to capture Care Area shapes which need a higher scan resolution with a tune able pattern halo. In the pattern matching step, when the patterns are matched, a bounding box marker will be output to identify the high resolution area. The equation-based DRC and Pattern Matching effectively work together for different scan phases.

Responses of Cells in the Midbrain Near-Response Area in Monkeys with Strabismus

PubMed Central

Das, Vallabh E.

2012-01-01

Purpose. To investigate whether neuronal activity within the supraoculomotor area (SOA—monosynaptically connected to medial rectus motoneurons and encode vergence angle) of strabismic monkeys was correlated with the angle of horizontal misalignment and therefore helps to define the state of strabismus. Methods. Single-cell neural activity was recorded from SOA neurons in two monkeys with exotropia as they performed eye movement tasks during monocular viewing. Results. Horizontal strabismus angle varied depending on eye of fixation (dissociated horizontal deviation) and the activity of SOA cells (n = 35) varied in correlation with the angle of strabismus. Both near-response (cells that showed larger firing rates for smaller angles of exotropia) and far-response (cells that showed lower firing rates for smaller angles of exotropia) cells were identified. SOA cells showed no modulation of activity with changes in conjugate eye position as tested during smooth-pursuit, thereby verifying that the responses were related to binocular misalignment. SOA cell activity was also not correlated with change in horizontal misalignment due to A-patterns of strabismus. Comparison of SOA population activity in strabismic animals and normal monkeys (described in the literature) show that both neural thresholds and neural sensitivities are altered in the strabismic animals compared with the normal animals. Conclusions. SOA cell activity is important in determining the state of horizontal strabismus, possibly by altering vergence tone in extraocular muscle. The lack of correlated SOA activity with changes in misalignment due to A/V patterns suggest that circuits mediating horizontal strabismus angle and those that mediate A/V patterns are different. PMID:22562519

Tunable liquid microlens array driven by pyroelectric effect: full interferometric characterization

NASA Astrophysics Data System (ADS)

Miccio, Lisa; Grilli, Simonetta; Vespini, Veronica; Ferraro, Pietro

2008-09-01

Liquid lenses with adjustable focal length are of great interest in the field of microfluidic devices. They are, usually, realized by electrowetting effect after electrodes patterning on a hydrofobic substrate. Applications are possible in many fields ranging from commercial products such as digital cameras to biological cell sorting. We realized an open array of liquid lenses with adjustable focal length without electrode patterning. We used a z-cut Lithium Niobate crystal (LN) as substrate and few microliters of an oily substance to obtain the droplets array. The spontaneous polarization of LN crystals is reversed by the electric field poling process, thus enabling the realization of periodically poled LN (PPLN) crystals. The substrate consists of a two-dimensional square array of reversed domains with a period around 200 μm. Each domain presents an hexagonal geometry due to the crystal structure. PPLN is first covered by a thin and homogeneous layer of the above mentioned liquid and therefore its temperature is changed by means of a digitally controlled hot plate. During heating and cooling process there is a rearrangement of the liquid layer until it reaches the final topography. Lenses formation is due to the superficial tension changing at the liquid-solid interface by means of the pyroelectric effect. Such effect allows to create a two-dimensional lens pattern of tunable focal length without electrodes. The temporal evolution of both shape and focal length lenses are quantitatively measured by Digital Holographic Microscopy. Array imaging properties and quantitative analysis of the lenses features and aberrations are presented.

Blob-hole correlation model for edge turbulence and comparisons with NSTX gas puff imaging data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myra, J. R.; Zweben, S. J.; Russell, D. A.

We report that gas puff imaging (GPI) observations made in NSTX [Zweben S J, et al., 2017 Phys. Plasmas 24 102509] have revealed two-point spatial correlations of edge and scrape-off layer turbulence in the plane perpendicular to the magnetic field. A common feature is the occurrence of dipole-like patterns with significant regions of negative correlation. In this paper, we explore the possibility that these dipole patterns may be due to blob-hole pairs. Statistical methods are applied to determine the two-point spatial correlation that results from a model of blob-hole pair formation. It is shown that the model produces dipole correlationmore » patterns that are qualitatively similar to the GPI data in several respects. Effects of the reference location (confined surfaces or scrape-off layer), a superimposed random background, hole velocity and lifetime, and background sheared flows are explored and discussed with respect to experimental observations. Additional analysis of the experimental GPI dataset is performed to further test this blob-hole correlation model. A time delay two-point spatial correlation study did not reveal inward propagation of the negative correlation structures that were postulated to correspond to holes in the data nor did it suggest that the negative correlation structures are due to neutral shadowing. However, tracking of the highest and lowest values (extrema) of the normalized GPI fluctuations shows strong evidence for mean inward propagation of minima and outward propagation of maxima, in qualitative agreement with theoretical expectations. Finally, other properties of the experimentally observed extrema are discussed.« less

Blob-hole correlation model for edge turbulence and comparisons with NSTX gas puff imaging data

DOE PAGES

Myra, J. R.; Zweben, S. J.; Russell, D. A.

2018-05-15

We report that gas puff imaging (GPI) observations made in NSTX [Zweben S J, et al., 2017 Phys. Plasmas 24 102509] have revealed two-point spatial correlations of edge and scrape-off layer turbulence in the plane perpendicular to the magnetic field. A common feature is the occurrence of dipole-like patterns with significant regions of negative correlation. In this paper, we explore the possibility that these dipole patterns may be due to blob-hole pairs. Statistical methods are applied to determine the two-point spatial correlation that results from a model of blob-hole pair formation. It is shown that the model produces dipole correlationmore » patterns that are qualitatively similar to the GPI data in several respects. Effects of the reference location (confined surfaces or scrape-off layer), a superimposed random background, hole velocity and lifetime, and background sheared flows are explored and discussed with respect to experimental observations. Additional analysis of the experimental GPI dataset is performed to further test this blob-hole correlation model. A time delay two-point spatial correlation study did not reveal inward propagation of the negative correlation structures that were postulated to correspond to holes in the data nor did it suggest that the negative correlation structures are due to neutral shadowing. However, tracking of the highest and lowest values (extrema) of the normalized GPI fluctuations shows strong evidence for mean inward propagation of minima and outward propagation of maxima, in qualitative agreement with theoretical expectations. Finally, other properties of the experimentally observed extrema are discussed.« less

Using color intensity projections to visualize air flow in operating theaters with the goal of reducing infections

NASA Astrophysics Data System (ADS)

Cover, Keith S.; van Asperen, Niek; de Jong, Joost; Verdaasdonk, Rudolf M.

2013-03-01

Infection following neurosurgery is all too common. One possible source of infection is the transportation of dust and other contaminates into the open wound by airflow within the operating theatre. While many modern operating theatres have a filtered, uniform and gentle flow of air cascading down over the operating table from a large area fan in the ceiling, many obstacles might introduce turbulence into the laminar flow including lights, equipment and personal. Schlieren imaging - which is sensitive to small disturbances in the laminar flow such as breathing and turbulence caused by air warmed by a hand at body temperature - was used to image the air flow due to activities in an operating theatre. Color intensity projections (CIPs) were employed to reduce the workload of analyzing the large amount of video data. CIPs - which has been applied to images in angiography, 4D CT, nuclear medicine and astronomy - summarizes the changes over many gray scale images in a single color image in a way which most interpreters find intuitive. CIPs uses the hue, saturation and brightness of the color image to encode the summary. Imaging in an operating theatre showed substantial disruptions to the airflow due to equipment such as the lighting. When these disruptions are combined with such minor factors as heat from the hand, reversal of the preferred airflow patterns can occur. These reversals of preferred airflow patterns have the potential to transport contaminates into the open wound. Further study is required to understand both the frequency of the reversed airflow patterns and the impact they may have on infection rates.

Full spinal cord regeneration after total transection is not possible due to entropy change.

PubMed

Zielinski, P; Sokal, P

2016-09-01

Transected spinal cord regeneration is a main challenge of regenerative medicine. The mainstream of research is focused on the promotion of spinal axons growth, which is strongly inhibited in mammals. Assuming that the inhibition of the axonal growth may be ever overcome, the complexity of neural reconnections may be the second serious stand to overcome. Peripheral nerve axons regeneration seem to form a random pattern of their targets reconnections. The hypothesis is that due to the laws of entropy or irreversible information loss the full spinal cord restoration after the transection is not possible. The hypothesis is discussed based on several assumptions. Simplifying the dissertation spinal cord is represented by 2millions of pyramidal axons. After the transection each of these axons has to make a growth and reconnect with exactly matching targets below the transection, in the same number. Axons are guided by neurotrophic factors and afterwards reconnected with neuroplasticity mechanisms. Assuming random reconnections, there are 2,000,000! permutations [Formula: see text] , therefore the chance of ideally random but correct reconnection of pyramidal axons with adequate targets is 1/2,000,000!. Apart from pyramidal axons, there are other axons, like extrapyramidal, sensory and associative. Empirical data and analysis of neurotrophic factors and organogenesis mechanisms may seem to slightly contradict the hypothesis, but strictly adhering to the second law of thermodynamics and entropy laws the full restoration of the transected cord may never be possible. Copyright © 2016 Elsevier Ltd. All rights reserved.

The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study.

PubMed

Bergmann, Manuela M; Rehm, Jürgen; Klipstein-Grobusch, Kerstin; Boeing, Heiner; Schütze, Madlen; Drogan, Dagmar; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Teucher, Birgit; Kaaks, Rudolph; Trichopoulou, Antonia; Benetou, Vassiliki; Trichopoulos, Dimitrios; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Beulens, Joline Wj; Redondo, Maria Luisa; Duell, Eric J; Molina-Montes, Esther; Navarro, Carmen; Barricarte, Aurelio; Arriola, Larraitz; Allen, Naomi E; Crowe, Francesca L; Khaw, Kay-Tee; Wareham, Nick; Romaguera, Dora; Wark, Petra A; Romieu, Isabelle; Nunes, Luciana; Riboli, Elio; Ferrari, Pietro

2013-12-01

There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrollment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (≤1 and ≤0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrollment. Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life.

The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

PubMed Central

Bergmann, Manuela M; Rehm, Jürgen; Klipstein-Grobusch, Kerstin; Boeing, Heiner; Schütze, Madlen; Drogan, Dagmar; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Fagherazzi, Guy; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Teucher, Birgit; Kaaks, Rudolph; Trichopoulou, Antonia; Benetou, Vassiliki; Trichopoulos, Dimitrios; Palli, Domenico; Pala, Valeria; Tumino, Rosario; Vineis, Paolo; Beulens, Joline WJ; Redondo, Maria Luisa; Duell, Eric J; Molina-Montes, Esther; Navarro, Carmen; Barricarte, Aurelio; Arriola, Larraitz; Allen, Naomi E; Crowe, Francesca L; Khaw, Kay-Tee; Wareham, Nick; Romaguera, Dora; Wark, Petra A; Romieu, Isabelle; Nunes, Luciana; Riboli, Elio; Ferrari, Pietro

2013-01-01

Background There is limited evidence for an association between the pattern of lifetime alcohol use and cause-specific risk of death. Methods Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrolment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. Results The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (>5 drinks/day for men and >2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (≤1 and ≤0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used <5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34–46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrolment. Conclusions Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life. PMID:24415611

Ten-year chemical signatures associated with long-range transport observed in the free troposphere over the central North Atlantic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, B.; Owen, R. C.; Perlinger, J. A.

Ten-year observations of trace gases at Pico Mountain Observatory (PMO), a free troposphere site in the central North Atlantic, were classified by transport patterns using the Lagrangian particle dispersion model, FLEXPART. The classification enabled identifying trace gas mixing ratios associated with background air and long- range transport of continental emissions, which were defined as chemical signatures. Comparison between the chemical signatures revealed the impacts of natural and anthropogenic sources, as well as chemical and physical processes during long transport, on air composition in the remote North Atlantic. Transport of North American anthropogenic emissions (NA-Anthro) and summertime wildfire plumes (Fire) significantlymore » enhanced CO and O 3 at PMO. Summertime CO enhancements caused by NA-Anthro were found to have been decreasing by a rate of 0.67 ± 0.60 ppbv/year in the ten-year period, due possibly to reduction of emissions in North America. Downward mixing from the upper troposphere and stratosphere due to the persistent Azores-Bermuda anticyclone causes enhanced O 3 and nitrogen oxides. The d [O 3]/d [CO] value was used to investigate O 3 sources and chemistry in different transport patterns. The transport pattern affected by Fire had the lowest d [O 3]/d [CO], which was likely due to intense CO production and depressed O 3 production in wildfire plumes. Slightly enhanced O 3 and d [O 3]/d [CO] were found in the background air, suggesting that weak downward mixing from the upper troposphere is common at PMO. Enhancements of both butane isomers were found during upslope flow periods, indicating contributions from local sources. The consistent ratio of butane isomers associated with the background air and NA-anthro implies no clear difference in the oxidation rates of the butane isomers during long transport. Based on observed relationships between non-methane hydrocarbons, the averaged photochemical age of the air masses at PMO was estimated to be 11 ± 4 days.« less

Ten-year chemical signatures associated with long-range transport observed in the free troposphere over the central North Atlantic

DOE PAGES

Zhang, B.; Owen, R. C.; Perlinger, J. A.; ...

2017-03-06

Ten-year observations of trace gases at Pico Mountain Observatory (PMO), a free troposphere site in the central North Atlantic, were classified by transport patterns using the Lagrangian particle dispersion model, FLEXPART. The classification enabled identifying trace gas mixing ratios associated with background air and long- range transport of continental emissions, which were defined as chemical signatures. Comparison between the chemical signatures revealed the impacts of natural and anthropogenic sources, as well as chemical and physical processes during long transport, on air composition in the remote North Atlantic. Transport of North American anthropogenic emissions (NA-Anthro) and summertime wildfire plumes (Fire) significantlymore » enhanced CO and O 3 at PMO. Summertime CO enhancements caused by NA-Anthro were found to have been decreasing by a rate of 0.67 ± 0.60 ppbv/year in the ten-year period, due possibly to reduction of emissions in North America. Downward mixing from the upper troposphere and stratosphere due to the persistent Azores-Bermuda anticyclone causes enhanced O 3 and nitrogen oxides. The d [O 3]/d [CO] value was used to investigate O 3 sources and chemistry in different transport patterns. The transport pattern affected by Fire had the lowest d [O 3]/d [CO], which was likely due to intense CO production and depressed O 3 production in wildfire plumes. Slightly enhanced O 3 and d [O 3]/d [CO] were found in the background air, suggesting that weak downward mixing from the upper troposphere is common at PMO. Enhancements of both butane isomers were found during upslope flow periods, indicating contributions from local sources. The consistent ratio of butane isomers associated with the background air and NA-anthro implies no clear difference in the oxidation rates of the butane isomers during long transport. Based on observed relationships between non-methane hydrocarbons, the averaged photochemical age of the air masses at PMO was estimated to be 11 ± 4 days.« less

Contrast-enhanced ultrasound in diagnosis and characterization of focal hepatic lesions.

PubMed

Molins, Inés Gómez; Font, Juan Manuel Fernández; Alvaro, Juan Carrero; Navarro, Jose Luís Lledó; Gil, Marta Fernández; Rodríguez, Conrado M Fernández

2010-12-28

The extensive use of imaging techniques in differential diagnosis of abdominal conditions and screening of hepatocellular carcinoma in patients with chronic hepatic diseases, has led to an important increase in identification of focal liver lesions. The development of contrast-enhanced ultrasound (CEUS) opens a new window in the diagnosis and follow-up of these lesions. This technique offers obvious advantages over the computed tomography and magnetic resonance, without a decrease in its sensitivity and specificity. The new second generation contrast agents, due to their intravascular distribution, allow a continuous evaluation of the enhancement pattern, which is crucial in characterization of liver lesions. The dual blood supply in the liver shows three different phases, namely arterial, portal and late phases. The enhancement during portal and late phases can give important information about the lesion's behavior. Each liver lesion has a different enhancement pattern that makes possible an accurate approach to their diagnosis. The role of emerging techniques as a contrast-enhanced three-dimensional US is also discussed. In this article, the advantages, indications and technique employed during CEUS and the different enhancement patterns of most benign and malignant focal liver lesions are discussed.

An equilibrium-point model for fast, single-joint movement: II. Similarity of single-joint isometric and isotonic descending commands.

PubMed

Latash, M L; Gottlieb, G L

1991-09-01

The model for isotonic movements introduced in the preceding article in this issue is used to account for isometric contractions. Isotonic movements and isometric contractions are analyzed as consequences of one motor program acting under different peripheral conditions. Differences in isotonic and isometric EMG patterns are analyzed theoretically. Computer simulation of the EMG patterns was performed both with and without the inclusion of possible effects of reciprocal inhibition. A series of experiments was performed to test the model. The subjects made fast isotonic movements that were unexpectedly blocked at the very beginning in some of the trials. The observed differences in the EMG patterns between blocked and unblocked trials corresponded to the model's predictions. The results suggest that these differences are due to the action of a tonic stretch reflex rather than to preprogrammed reactions. The experimental and simulation findings, and also the data from the literature, are discussed in the framework of the model and the dual-strategy hypothesis. They support the hypothesis that the motor control system uses one of a few standardized subprograms, specifying a small number of parameters to match a specific task.

Image processing and recognition for biological images.

PubMed

Uchida, Seiichi

2013-05-01

This paper reviews image processing and pattern recognition techniques, which will be useful to analyze bioimages. Although this paper does not provide their technical details, it will be possible to grasp their main tasks and typical tools to handle the tasks. Image processing is a large research area to improve the visibility of an input image and acquire some valuable information from it. As the main tasks of image processing, this paper introduces gray-level transformation, binarization, image filtering, image segmentation, visual object tracking, optical flow and image registration. Image pattern recognition is the technique to classify an input image into one of the predefined classes and also has a large research area. This paper overviews its two main modules, that is, feature extraction module and classification module. Throughout the paper, it will be emphasized that bioimage is a very difficult target for even state-of-the-art image processing and pattern recognition techniques due to noises, deformations, etc. This paper is expected to be one tutorial guide to bridge biology and image processing researchers for their further collaboration to tackle such a difficult target. © 2013 The Author Development, Growth & Differentiation © 2013 Japanese Society of Developmental Biologists.

Variation of thermal parameters in two different color morphs of a diurnal poison toad, Melanophryniscus rubriventris (Anura: Bufonidae).

PubMed

Sanabria, Eduardo A; Vaira, Marcos; Quiroga, Lorena B; Akmentins, Mauricio S; Pereyra, Laura C

2014-04-01

We study the variation in thermal parameters in two contrasting populations Yungas Redbelly Toads (Melanophryniscus rubriventris) with different discrete color phenotypes comparing field body temperatures, critical thermal maximum and heating rates. We found significant differences in field body temperatures of the different morphs. Temperatures were higher in toads with a high extent of dorsal melanization. No variation was registered in operative temperatures between the study locations at the moment of capture and processing. Critical thermal maximum of toads was positively related with the extent of dorsal melanization. Furthermore, we founded significant differences in heating rates between morphs, where individuals with a high extent of dorsal melanization showed greater heating rates than toads with lower dorsal melanization. The color pattern-thermal parameter relationship observed may influence the activity patterns and body size of individuals. Body temperature is a modulator of physiological and behavioral functions in amphibians, influencing daily and seasonal activity, locomotor performance, digestion rate and growth rate. It is possible that some growth constraints may arise due to the relationship of color pattern-metabolism allowing different morphs to attain similar sizes at different locations instead of body-size clines. Copyright © 2014. Published by Elsevier Ltd.

The potential for free and mixed convection in sedimentary basins

USGS Publications Warehouse

Raffensperger, Jeff P.; Vlassopoulos, D.

1999-01-01

Free thermal convection and mixed convection are considered as potential mechanisms for mass and heat transport in sedimentary basins. Mixed convection occurs when horizontal flows (forced convection) are superimposed on thermally driven flows. In cross section, mixed convection is characterized by convection cells that migrate laterally in the direction of forced convective flow. Two-dimensional finite-element simulations of variable-density groundwater flow and heat transport in a horizontal porous layer were performed to determine critical mean Rayleigh numbers for the onset of free convection, using both isothermal and semi-conductive boundaries. Additional simulations imposed a varying lateral fluid flux on the free-convection pattern. Results from these experiments indicate that forced convection becomes dominant, completely eliminating buoyancy-driven circulation, when the total forced-convection fluid flux exceeds the total flux possible due to free convection. Calculations of the thermal rock alteration index (RAI=q????T) delineate the patterns of potential diagenesis produced by fluid movement through temperature gradients. Free convection produces a distinct pattern of alternating positive and negative RAIs, whereas mixed convection produces a simpler layering of positive and negative values and in general less diagenetic alteration. ?? Springer-Verlag.

Triple/quadruple patterning layout decomposition via novel linear programming and iterative rounding

NASA Astrophysics Data System (ADS)

Lin, Yibo; Xu, Xiaoqing; Yu, Bei; Baldick, Ross; Pan, David Z.

2016-03-01

As feature size of the semiconductor technology scales down to 10nm and beyond, multiple patterning lithography (MPL) has become one of the most practical candidates for lithography, along with other emerging technologies such as extreme ultraviolet lithography (EUVL), e-beam lithography (EBL) and directed self assembly (DSA). Due to the delay of EUVL and EBL, triple and even quadruple patterning are considered to be used for lower metal and contact layers with tight pitches. In the process of MPL, layout decomposition is the key design stage, where a layout is split into various parts and each part is manufactured through a separate mask. For metal layers, stitching may be allowed to resolve conflicts, while it is forbidden for contact and via layers. In this paper, we focus on the application of layout decomposition where stitching is not allowed such as for contact and via layers. We propose a linear programming and iterative rounding (LPIR) solving technique to reduce the number of non-integers in the LP relaxation problem. Experimental results show that the proposed algorithms can provide high quality decomposition solutions efficiently while introducing as few conflicts as possible.

Light induced DEP for immobilizing and orienting Escherichia coli bacteria

NASA Astrophysics Data System (ADS)

Miccio, Lisa; Marchesano, Valentina; Mugnano, Martina; Grilli, Simonetta; Ferraro, Pietro

2016-01-01

Manipulating bacteria and understanding their behavior when interacting with different substrates are of fundamental importance for patterning, detection, and any other topics related to health-care, food-enterprise, etc. Here, we adopt an innovative dielectrophoretic (DEP) approach based on electrode-free DEP for investigating smart but simple strategies for immobilization and orientation of bacteria. Escherichia coli DH5-alpha strain has been selected as subject of the study. The light induced DEP is achieved through ferroelectric iron-doped lithium niobate crystals used as substrates. Due to the photorefractive (PR) property of such material, suitable light patterns allow writing spatial-charges-distribution inside its volume and the resultant electric fields are able to immobilize E. coli on the surface. The experiments showed that, after laser irradiation, about 80% of bacteria is blocked and oriented along a particular direction on the crystals within an area of few square centimeters. The investigation presented here could open the way for detection or patterning applications based on a new driving mechanism. Future perspectives also include the possibility to actively switch by light the DEP forces, through the writing/erasing characteristic of PR fields, to dynamically control biofilm spatial structure and arrangement.

[Disturbed respiratory cycle accompanying hypoxic-ischemic encephalopathy].

PubMed

Saito, Yoshiaki; Masuko, Kaori; Kaneko, Kaori; Saito, Kazuyo; Chikumaru, Yuri; Iwamoto, Hiroko; Matsui, Akira; Kimura, Seiji

2005-09-01

We report the case of a 2-year-old boy who experienced total asphyxia at 4 months of age, and suffered abnormalities at specific phases of the respiratory cycle. The patient was bedridden due to severe tetraplegia and showed little response to external stimuli. He has been tube-fed since the initial asphyxia and a tracheotomy was performed after recurrent hypoxic episodes as a result of the respiratory dysfunction. Upon examination, his respiratory pattern was characterized by arrest during the inspiratory phase with a possible over-riding secondary inspiration. The respiratory pause at the inspiratory phase was markedly prolonged during an episode of pulmonary infection, resulting in recurrent cyanosis that necessitated artificial ventilation. The "second" inspiration typically occurred during the mid- or late-inspiratory phases, with this pattern often shown to be variable after epileptic seizures. The characteristic breathing of this patient suggested that difficulty in forming a normal respiratory cycle, other than during periods of hypoventilation or apnoea, could be a significant respiratory dysfunction following asphyxiation. Strategies for the management of such patients should be carefully designed after close observation of breathing patterns within the respiratory cycle, and with consideration for the influence of epileptic seizures and other inputs from somatic afferents.

Dual binding mode in cohesin-dockerin complexes as assessed through stretching studies

NASA Astrophysics Data System (ADS)

Wojciechowski, Michał; Cieplak, Marek

2016-10-01

A recent experimental study by Jobst et al. of stretching of a wild-type (WT) cohesin-dockerin complex has identified two kinds of the force-displacement patterns, with a single or double-peaked final rupture, which are termed "short" and "long" here. This duality has been interpreted as arising from the existence of two kinds of binding. Here, we analyze the separation of two cohesin-dockerin complexes of C. thermocellum theoretically. We use a coarse-grained structure-based model and the values of the pulling speeds are nearly experimental. In their native states, the two systems differ in the mutual binding orientations of the molecules in the complex. We demonstrate that the WT complex (PDB:1OHZ) unravels along two possible pathways that are qualitatively consistent with the presence of the short and long patterns observed experimentally. On the other hand, the mutated complex (PDB:2CCL) leads only to short trajectories. The short and long stretching pathways also appear in the cohesin-dockerin-Xmodule complex (PDB:4IU3, WT) of R. flavefaciens. Thus the duality in the stretching patterns need not be necessarily due to the duality in binding.

Tolerance adaptation and precipitation changes complicate latitudinal patterns of climate change impacts.

PubMed

Bonebrake, Timothy C; Mastrandrea, Michael D

2010-07-13

Global patterns of biodiversity and comparisons between tropical and temperate ecosystems have pervaded ecology from its inception. However, the urgency in understanding these global patterns has been accentuated by the threat of rapid climate change. We apply an adaptive model of environmental tolerance evolution to global climate data and climate change model projections to examine the relative impacts of climate change on different regions of the globe. Our results project more adverse impacts of warming on tropical populations due to environmental tolerance adaptation to conditions of low interannual variability in temperature. When applied to present variability and future forecasts of precipitation data, the tolerance adaptation model found large reductions in fitness predicted for populations in high-latitude northern hemisphere regions, although some tropical regions had comparable reductions in fitness. We formulated an evolutionary regional climate change index (ERCCI) to additionally incorporate the predicted changes in the interannual variability of temperature and precipitation. Based on this index, we suggest that the magnitude of climate change impacts could be much more heterogeneous across latitude than previously thought. Specifically, tropical regions are likely to be just as affected as temperate regions and, in some regions under some circumstances, possibly more so.

Contrast-enhanced ultrasound in diagnosis and characterization of focal hepatic lesions

PubMed Central

Molins, Inés Gómez; Font, Juan Manuel Fernández; Álvaro, Juan Carrero; Navarro, Jose Luís Lledó; Gil, Marta Fernández; Rodríguez, Conrado M Fernández

2010-01-01

The extensive use of imaging techniques in differential diagnosis of abdominal conditions and screening of hepatocellular carcinoma in patients with chronic hepatic diseases, has led to an important increase in identification of focal liver lesions. The development of contrast-enhanced ultrasound (CEUS) opens a new window in the diagnosis and follow-up of these lesions. This technique offers obvious advantages over the computed tomography and magnetic resonance, without a decrease in its sensitivity and specificity. The new second generation contrast agents, due to their intravascular distribution, allow a continuous evaluation of the enhancement pattern, which is crucial in characterization of liver lesions. The dual blood supply in the liver shows three different phases, namely arterial, portal and late phases. The enhancement during portal and late phases can give important information about the lesion’s behavior. Each liver lesion has a different enhancement pattern that makes possible an accurate approach to their diagnosis. The role of emerging techniques as a contrast-enhanced three-dimensional US is also discussed. In this article, the advantages, indications and technique employed during CEUS and the different enhancement patterns of most benign and malignant focal liver lesions are discussed. PMID:21225000

Spatiotemporal deformation patterns of the Lake Urmia Causeway as characterized by multisensor InSAR analysis.

PubMed

Karimzadeh, Sadra; Matsuoka, Masashi; Ogushi, Fumitaka

2018-04-03

We present deformation patterns in the Lake Urmia Causeway (LUC) in NW Iran based on data collected from four SAR sensors in the form of interferometric synthetic aperture radar (InSAR) time series. Sixty-eight images from Envisat (2004-2008), ALOS-1 (2006-2010), TerraSAR-X (2012-2013) and Sentinel-1 (2015-2017) were acquired, and 227 filtered interferograms were generated using the small baseline subset (SBAS) technique. The rate of line-of-sight (LOS) subsidence of the LUC peaked at 90 mm/year between 2012 and 2013, mainly due to the loss of most of the water in Lake Urmia. Principal component analysis (PCA) was conducted on 200 randomly selected time series of the LUC, and the results are presented in the form of the three major components. The InSAR scores obtained from the PCA were used in a hydro-thermal model to investigate the dynamics of consolidation settlement along the LUC based on detrended water level and temperature data. The results can be used to establish a geodetic network around the LUC to identify more detailed deformation patterns and to help plan future efforts to reduce the possible costs of damage.

Influence of encoding instructions and response bias on cross-cultural differences in specific recognition.

PubMed

Paige, Laura E; Amado, Selen; Gutchess, Angela H

2017-10-01

Prior cross-cultural research has reported cultural variations in memory. One study revealed that Americans remembered images with more perceptual detail than East Asians (Millar et al. in Cult Brain 1(2-4):138-157, 2013). However, in a later study, this expected pattern was not replicated, possibly due to differences in encoding instructions (Paige et al. in Cortex 91:250-261, 2017). The present study sought to examine when cultural variation in memory-related decisions occur and the role of instructions. American and East Asian participants viewed images of objects while making a Purchase decision or an Approach decision and later completed a surprise recognition test. Results revealed Americans had higher hit rates for specific memory, regardless of instruction type, and a less stringent response criterion relative to East Asians. Additionally, a pattern emerged where the Approach decision enhanced hit rates for specific memory relative to the Purchase decision only when administered first; this pattern did not differ across cultures. Results suggest encoding instructions do not magnify cross-cultural differences in memory. Ultimately, cross-cultural differences in response bias, rather than memory sensitivity per se, may account for findings of cultural differences in memory specificity.

Global Patterns of Lightning Properties Derived by OTD and LIS

NASA Technical Reports Server (NTRS)

Beirle, Steffen; Koshak, W.; Blakeslee, R.; Wagner, T.

2014-01-01

The satellite instruments Optical Transient Detector (OTD) and Lightning Imaging Sensor (LIS) provide unique empirical data about the frequency of lightning flashes around the globe (OTD), and the tropics (LIS), which 5 has been used before to compile a well received global climatology of flash rate densities. Here we present a statistical analysis of various additional lightning properties derived from OTD/LIS, i.e. the number of so-called "events" and "groups" per flash, as well as 10 the mean flash duration, footprint and radiance. These normalized quantities, which can be associated with the flash "strength", show consistent spatial patterns; most strikingly, oceanic flashes show higher values than continental flashes for all properties. Over land, regions with high (Eastern US) 15 and low (India) flash strength can be clearly identified. We discuss possible causes and implications of the observed regional differences. Although a direct quantitative interpretation of the investigated flash properties is difficult, the observed spatial patterns provide valuable information for the 20 interpretation and application of climatological flash rates. Due to the systematic regional variations of physical flash characteristics, viewing conditions, and/or measurement sensitivities, parametrisations of lightning NOx based on total flash rate densities alone are probably affected by regional biases.

Disentangling the influence of environmental and anthropogenic factors on the distribution of endemic vascular plants in Sardinia.

PubMed

Fois, Mauro; Fenu, Giuseppe; Cañadas, Eva Maria; Bacchetta, Gianluigi

2017-01-01

Due to the impelling urgency of plant conservation and the increasing availability of high resolution spatially interpolated (e.g. climate variables) and categorical data (e.g. land cover and vegetation type), many recent studies have examined relationships among plant species distributions and a diversified set of explanatory factors; nevertheless, global and regional patterns of endemic plant richness remain in many cases unexplained. One such pattern is the 294 endemic vascular plant taxa recorded on a 1 km resolution grid on the environmentally heterogeneous island of Sardinia. Sixteen predictors, including topographic, geological, climatic and anthropogenic factors, were used to model local (number of taxa inside each 1 km grid cell) Endemic Vascular Plant Richness (EVPR). Generalized Linear Models were used to evaluate how each factor affected the distribution of local EVPR. Significant relationships with local EVPR and topographic, geological, climatic and anthropogenic factors were found. In particular, elevation explained the larger fraction of variation in endemic richness but other environmental factors (e.g. precipitation seasonality and slope) and human-related factors (e.g. the Human Influence Index (HII) and the proportion of anthropogenic land uses) were, respectively, positively and negatively correlated with local EVPR. Regional EVPR (number of endemic taxa inside each 100 m elevation interval) was also measured to compare local and regional EVPR patterns along the elevation gradient. In contrast to local, regional EVPR tended to decrease with altitude partly due to the decreasing area covered along altitude. The contrasting results between local and regional patterns suggest that local richness increases as a result of increased interspecific aggregation along altitude, whereas regional richness may depend on the interaction between area and altitude. This suggests that the shape and magnitude of the species-area relationship might vary with elevation. This work provides-for the first time in Sardinia-a comprehensive analysis of the influence of environmental factors on the pattern of EVPR in the entire territory, from sea level to the highest peaks. Elevation, as well as other environmental and human-related variables, were confirmed to be influencing factors. In addition, variations of EVPR patterns at regional-to-local spatial scales inspire next investigations on the possible interaction between elevation and area in explaining patterns of plant species richness.

Characterization of Sheet Fracture Patterns in Polygonal-Jointed Lavas at Kokostick Butte, OR, and Mazama Ridge, WA: Investigation and Interpretation of Their Formation and Significance

NASA Astrophysics Data System (ADS)

Lodge, R. W.; Lescinsky, D. T.

2006-12-01

Polygonal joints in lava flows ("columns") are commonly equant leading to a model of formation associated with cooling in an isotropic stress field. This model, however, does not explain rectangular columns, sheet-like fractures, fractures with crosscutting relationships, and fractures with orientations other than perpendicular to the cooling surface. These fracture patterns are often observed at glaciated volcanoes. The presence of preferential fracture orientations suggests an applied stress component likely due to environmental conditions such as the presence of glaciers or flow dynamics such as down-slope settling or flow margin inflation. During this study we investigated the formation and significance of these non-equant fracture patterns to propose a model for their formation. These `abnormal' fracture patterns have not been discussed in the literature and may be important to better understanding the cooling conditions of such lava flows. To test these possibilities we studied Kokostick Butte dacite flow, OR (near South Sister), and Mazama Ridge andesite flow at Mount Rainier, WA. Both of these flows have well developed sheet-like fractures and display evidence of ice-contact during eruption and emplacement. Sheet fractures are long and continuous fractures that have perpendicular connecting fractures forming rectangular columns. The sheet-like fractures are largely parallel to each other on the exposure surface and the connecting fractures vary locally from primary fractures (associated with cooling toward flow interior) to secondary fractures (associated with cooling by water infiltration). Detailed measurements of fracture orientations and spacing were collected at Kokostick Butte and Mazama Ridge to examine the relationship between the sheet fractures and flow geometry. Preliminary results support this relationship and suggest these patterns likely form due to shear associated with small amounts of flow advance by the rapidly cooling lava. Laboratory studies have been undertaken to complement the field observations and measurements. Starch- water experiments have been proven a useful analogue for lava column formation. Various experimental setups involving different mixture thicknesses and compression of the mixture were utilized to simulate the stresses acting during ponding of lava against glacial ice and to produce different fracture morphologies and patterns. Initial results show that compression of the starch slurry results in non-equant fracture patterns with some sheet-like fracturing present.

Solvent-vapor-assisted dewetting of prepatterned thin polymer films: control of morphology, order, and pattern miniaturization.

PubMed

Bhandaru, Nandini; Goohpattader, Partho Sarathi; Faruqui, Danish; Mukherjee, Rabibrata; Sharma, Ashutosh

2015-03-17

Ultrathin (<100 nm) unstable polymer films exposed to a solvent vapor dewet by the growth of surface instability, the wavelength (λ) of which depends on the film thickness (h(f)). While the dewetting of a flat polymer thin film results in random structures, we show that the dewetting of a prepatterned film results in myriad ordered mesoscale morphologies under specific conditions. Such a film undergoes rupture over the thinnest parts when the initial local thickness of these zones (h(rm)) is lower than a limiting thickness h(lim) ≈ 10 nm. Additionally, the width of the pattern grooves (l(s)) must be wider than λ(s) corresponding to a flat film having a thickness of h(rm) for pattern-directed dewetting to take place over surface-tension-induced flattening. We first present an experimentally obtained morphology phase diagram that captures the conditions where a transition from surface-tension-induced flattening to pattern-directed-rupture takes place. Subsequently, we show the versatility of this technique in achieving a variety of aligned mesopatterns starting from a prepatterned film with simple grating geometry. The morphology of the evolving patterns depends on several parameters such as the initial film thickness (h(f)), prepattern amplitude (h(st)), duration of solvent vapor exposure (SVE), and wettability of the stamp used for patterning. Periodic rupture of the film at regular intervals imposes directionality on the evolving patterns, resulting in isolated long threads/cylindrical ridges of polymers, which subsequently disintegrate into an aligned array of droplets due to Rayleigh-Plateau instability under specific conditions. Other patterns such as a double periodic array of droplets and an array of holes are also possible to obtain. The evolution can be interrupted at any intermediate stage by terminating the solvent vapor annealing, allowing the creation of pattern morphology on demand. The created patterns are significantly miniaturized in size as compared to features obtained from dewetting a flat film with the same hf.

Soil moisture fluctuations recorded in Saharan dust deposits on Lanzarote (Canary Islands) over the last 180 ka

NASA Astrophysics Data System (ADS)

von Suchodoletz, H.; Oberhänsli, H.; Hambach, U.; Zöller, L.; Fuchs, M.; Faust, D.

2010-08-01

Aeolian sediments trapped in volcanically dammed valleys on Lanzarote, Canary Islands, were investigated in order to reveal environmental changes over the last 180 ka. Clay content and frequency-dependent magnetic susceptibility were used as proxies for pedogenesis and palaeo-soil moisture. During the last 180 ka, these proxies showed a general pattern of enhanced soil moisture during glacials and stadials and more arid conditions during interglacials and interstadials. Comparisons of these results with proxies from regional palaeoclimate studies identified a positive correlation with proxies of trade-wind strength off northwest Africa and inverse correlations with both sea surface temperatures in the northeast Atlantic and the extent of Mediterranean vegetation. Possible causes for the observed pattern include a glacial enhancement of precipitation from westerly cyclones, a change in relative humidity due to fluctuating air temperatures and an occasional influence of the African summer monsoon. Although it is not yet possible to clearly differentiate among these factors, it is clear that the first two factors must have been primarily dominant. These results represent the first quasi-continuous terrestrial data testifying to environmental changes in the northwest African coastal area for the last 180 ka and complement the abundant data derived from marine cores of the region. High latitude dynamics had a major influence in this area and were intermediated by North Atlantic sea surface temperatures. A possible negative correlation can also be observed with the orbital obliquity cycle with a 10 ka time lag, which is similar to the lag recorded from North Atlantic sea surface temperatures.

Investigation of Controls on Ice Dynamics in Northeast Greenland from Ice-Thickness Change Record Using Ice Sheet System Model (ISSM)

NASA Astrophysics Data System (ADS)

Csatho, B. M.; Larour, E. Y.; Schenk, A. F.; Schlegel, N.; Duncan, K.

2015-12-01

We present a new, complete ice thickness change reconstruction of the NE sector of the Greenland Ice Sheet for 1978-2014, partitioned into changes due to surface processes and ice dynamics. Elevation changes are computed from all available stereoscopic DEMs, and laser altimetry data (ICESat, ATM, LVIS). Surface Mass Balance and firn-compaction estimates are from RACMO2.3. Originating nearly at the divide of the Greenland Ice Sheet (GrIS), the dynamically active North East Ice Stream (NEGIS) is capable of rapidly transmitting ice-marginal forcing far inland. Thus, NEGIS provides a possible mechanism for a rapid drawdown of ice from the ice sheet interior as marginal warming, thinning and retreat continues. Our altimetry record shows accelerating dynamic thinning of Zachariæ Isstrom, initially limited to the deepest part of the fjord near the calving front (1978-2000) and then extending at least 75 km inland. At the same time, changes over the Nioghalvfjerdsfjorden (N79) Glacier are negligible. We also detect localized large dynamic changes at higher elevations on the ice sheet. These thickness changes, often occurring at the onset of fast flow, could indicate rapid variations of basal lubrication due to rerouting of subglacial drainage. We investigate the possible causes of the observed spatiotemporal pattern of ice sheet elevation changes using the Ice Sheet System Model (ISSM). This work build on our previous studies examining the sensitivity of ice flow within the Northeast Greenland Ice Stream (NEGIS) to key fields, including ice viscosity, basal drag. We assimilate the new altimetry record into ISSM to improve the reconstruction of basal friction and ice viscosity. Finally, airborne geophysical (gravity, magnetic) and ice-penetrating radar data is examined to identify the potential geologic controls on the ice thickness change pattern. Our study provides the first comprehensive reconstruction of ice thickness changes for the entire NEGIS drainage basin during the last 40 years. Through the use of ISSM, we examine possible mechanism explaining the observed changes. The improved understanding gained through this research will contribute better projections of future ice loss from this most vulnerable region of the GrIS.

Configurable pattern-based evolutionary biclustering of gene expression data

PubMed Central

2013-01-01

Background Biclustering algorithms for microarray data aim at discovering functionally related gene sets under different subsets of experimental conditions. Due to the problem complexity and the characteristics of microarray datasets, heuristic searches are usually used instead of exhaustive algorithms. Also, the comparison among different techniques is still a challenge. The obtained results vary in relevant features such as the number of genes or conditions, which makes it difficult to carry out a fair comparison. Moreover, existing approaches do not allow the user to specify any preferences on these properties. Results Here, we present the first biclustering algorithm in which it is possible to particularize several biclusters features in terms of different objectives. This can be done by tuning the specified features in the algorithm or also by incorporating new objectives into the search. Furthermore, our approach bases the bicluster evaluation in the use of expression patterns, being able to recognize both shifting and scaling patterns either simultaneously or not. Evolutionary computation has been chosen as the search strategy, naming thus our proposal Evo-Bexpa (Evolutionary Biclustering based in Expression Patterns). Conclusions We have conducted experiments on both synthetic and real datasets demonstrating Evo-Bexpa abilities to obtain meaningful biclusters. Synthetic experiments have been designed in order to compare Evo-Bexpa performance with other approaches when looking for perfect patterns. Experiments with four different real datasets also confirm the proper performing of our algorithm, whose results have been biologically validated through Gene Ontology. PMID:23433178

The mean zonal flow response to Rossby wave and gravity wave forcing in the equatorial lower stratosphere: Relationship to the QBO. [QBO (quasi-biennial oscillation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takahashi, M.; Holton, J.R.

1991-09-15

Observations show that the westerly acceleration of the equatorial quasi-biennial oscillation (QBO) can be accounted for by Kelvin waves, but that there is a deficiency in the easterly acceleration due to Rossby-gravity waves. Rossby waves and westward propagating gravity waves have been suggested as alternative sources for the easterly acceleration. We have tested the possible role of these two wave modes in a two-dimensional model of the QBO. When the easterly acceleration is due to Rossby waves, the zonal-mean response is steady; when it is due to gravity waves, an oscillation with some features similar to the QBO occurs, butmore » it is of short period and weak amplitude. A similar result occurs when a standing-wave forcing pattern is imposed. These results suggest that Rossby waves play only a minor role in the QBO, and that while the Rossby-gravity mode is essential, other gravity modes may also be important for the easterly phase. 12 refs., 22 figs.« less

Unsupervised discrimination of patterns in spiking neural networks with excitatory and inhibitory synaptic plasticity.

PubMed

Srinivasa, Narayan; Cho, Youngkwan

2014-01-01

A spiking neural network model is described for learning to discriminate among spatial patterns in an unsupervised manner. The network anatomy consists of source neurons that are activated by external inputs, a reservoir that resembles a generic cortical layer with an excitatory-inhibitory (EI) network and a sink layer of neurons for readout. Synaptic plasticity in the form of STDP is imposed on all the excitatory and inhibitory synapses at all times. While long-term excitatory STDP enables sparse and efficient learning of the salient features in inputs, inhibitory STDP enables this learning to be stable by establishing a balance between excitatory and inhibitory currents at each neuron in the network. The synaptic weights between source and reservoir neurons form a basis set for the input patterns. The neural trajectories generated in the reservoir due to input stimulation and lateral connections between reservoir neurons can be readout by the sink layer neurons. This activity is used for adaptation of synapses between reservoir and sink layer neurons. A new measure called the discriminability index (DI) is introduced to compute if the network can discriminate between old patterns already presented in an initial training session. The DI is also used to compute if the network adapts to new patterns without losing its ability to discriminate among old patterns. The final outcome is that the network is able to correctly discriminate between all patterns-both old and new. This result holds as long as inhibitory synapses employ STDP to continuously enable current balance in the network. The results suggest a possible direction for future investigation into how spiking neural networks could address the stability-plasticity question despite having continuous synaptic plasticity.

Procedure for measuring photon and vector meson circular polarization variation with respect to the reaction plane in relativistic heavy-ion collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, A. H.; Wang, G.

The electromagnetic (EM) eld pattern created by spectators in relativistic heavy-ion collisions plants a seed of positive (negative) magnetic helicity in the hemisphere above (below) the reaction plane. Owing to the chiral anomaly, the magnetic helicity interacts with the fermionic helicity of the collision system, and causes photons emitted in upper- and lower-hemispheres to have different preferences in the circular polarization. Similar helicity separation for massive particles, due to the global vorticity, is also possible. In this paper, we lay down a procedure to measure the variation of the circular polarization w.r.t the reaction plane in relativistic heavy-ion collisions formore » massless photons, as well as similar polarization patterns for vector mesons decaying into two daughters. We propose to study the yield differentially and compare the yield between upper- and lower-hemispheres in order to identify and quantify such effects.« less

[Disorders of sex development and proximal hypospadias].

PubMed

Oswald, J

2016-01-01

Children with ambiguous genitalia due to different chromosome or gonadal sex are a particular challenge concerning the diagnostic and therapeutic implications. Proximal hypospadias patients with normal gonadal development should be distinguished from children with DSD (disorders of sex development) to guarantee normal gender identity and the best possible surgical therapy. This paper focuses on the terminology, embryology, and pathophysiology of the different manifestations of DSD. The state of knowledge about this disease pattern with particular emphasis on proximal hypospadias based on national and international scientific discussions is presented. The different clinical pictures as well as therapeutic options of DSD with a special focus on recent literature and giving particular attention to patients with proximal hypospadias are presented. Because of the complexity of patients suffering from disorders of sex development an interdisciplinary DSD healthcare team including a paediatric endocrinologist as well as paediatric urologist should be provided. These specialists enable an accurate diagnosis in severe hypospadias patients without reference to DSD diseases patterns.

Procedure for measuring photon and vector meson circular polarization variation with respect to the reaction plane in relativistic heavy-ion collisions

DOE PAGES

Tang, A. H.; Wang, G.

2016-08-30

The electromagnetic (EM) eld pattern created by spectators in relativistic heavy-ion collisions plants a seed of positive (negative) magnetic helicity in the hemisphere above (below) the reaction plane. Owing to the chiral anomaly, the magnetic helicity interacts with the fermionic helicity of the collision system, and causes photons emitted in upper- and lower-hemispheres to have different preferences in the circular polarization. Similar helicity separation for massive particles, due to the global vorticity, is also possible. In this paper, we lay down a procedure to measure the variation of the circular polarization w.r.t the reaction plane in relativistic heavy-ion collisions formore » massless photons, as well as similar polarization patterns for vector mesons decaying into two daughters. We propose to study the yield differentially and compare the yield between upper- and lower-hemispheres in order to identify and quantify such effects.« less

Simulating dissolved organic carbon dynamics at the swedish integrated monitoring sites with the integrated catchments model for carbon, INCA-C.

PubMed

Futter, M N; Löfgren, S; Köhler, S J; Lundin, L; Moldan, F; Bringmark, L

2011-12-01

Surface water concentrations of dissolved organic carbon ([DOC]) are changing throughout the northern hemisphere due to changes in climate, land use and acid deposition. However, the relative importance of these drivers is unclear. Here, we use the Integrated Catchments model for Carbon (INCA-C) to simulate long-term (1996-2008) streamwater [DOC] at the four Swedish integrated monitoring (IM) sites. These are unmanaged headwater catchments with old-growth forests and no major changes in land use. Daily, seasonal and long-term variations in streamwater [DOC] driven by runoff, seasonal temperature and atmospheric sulfate (SO₄(2-)) deposition were observed at all sites. Using INCA-C, it was possible to reproduce observed patterns of variability in streamwater [DOC] at the four IM sites. Runoff was found to be the main short-term control on [DOC]. Seasonal patterns in [DOC] were controlled primarily by soil temperature. Measured SO₄(2-) deposition explained some of the long-term [DOC] variability at all sites.

Atmospheric pressure plasma-assisted femtosecond laser engraving of aluminium

NASA Astrophysics Data System (ADS)

Gerhard, Christoph; Gimpel, Thomas; Tasche, Daniel; Koch née Hoffmeister, Jennifer; Brückner, Stephan; Flachenecker, Günter; Wieneke, Stephan; Schade, Wolfgang; Viöl, Wolfgang

2018-05-01

In this contribution, we report on the impact of direct dielectric barrier discharge argon plasma at atmospheric pressure on femtosecond laser engraving of aluminium. It is shown that the assisting plasma strongly affects the surface geometry and formation of spikes of both laser-engraved single lines and patterns of adjacent lines with an appropriate overlap. Further, it was observed that the overall ablation depth is significantly increased in case of large-scale patterning whereas no notable differences in ablation depth are found for single lines. Several possible mechanisms and underlying effects of this behaviour are suggested. The increase in ablation depth is supposed to be due to a plasma-induced removal of debris particles from the cutting point via charging and oxidation as supported by EDX analysis of the re-solidified debris. Furthermore, the impact of a higher degree of surface wrinkling as well as direct interactions of plasma species with the aluminium surface on the ablation process are discussed.

The multiple functions of plant serine protease inhibitors

PubMed Central

Giri, Ashok P; Kaur, Harleen; Baldwin, Ian T

2011-01-01

Plant protease inhibitors (PIs) are a diverse group of proteins which have been intensely investigated due to their potential function in protecting plants against herbivorous insects by inhibiting digestive proteases. Although this mechanism has been well documented for a number of single PIs and their target enzymes, whether this mechanism protects plants in nature remains unclear. Moreover, many plants express a number of different PIs and it was unknown if these proteins work synergistically as defenses or if they also have other functions. We recently identified four serine PIs (SPI) of Solanum nigrum and demonstrated that they differ substantially in substrate specificity, accumulation patterns, and their effect against different natural herbivorous insects in field- and glasshouse experiments. These differences suggest that SPIs have at least partially diversified to provide protection against different attackers. Although we could not detect effects on plant development or growth when silencing SPIs, gene- and tissue-specific expression patterns suggest multiple functions in generative tissues, including a possible involvement in development. PMID:22004998

Changes in bacterial meningitis.

PubMed Central

Carter, P E; Barclay, S M; Galloway, W H; Cole, G F

1990-01-01

In 1964, one of us (WHG) undertook a retrospective study of bacterial meningitis in childhood in the north east of Scotland during the period 1946-61. We have recently carried out a similar review of cases occurring during 1971-86, to compare the incidence, mortality, and bacteriological patterns. During the earlier period 285 cases occurred, a total incidence of 16.9/100,000 children per year. In the later period 274 children were affected, an annual incidence of 17.8/100,000. The overall mortality rate fell dramatically from 11.9% to 1.8%, the latter figure comparing favourably with recent published studies from Scandinavia and the United States. There was a change in the bacteriological profile in the second period with a significant rise in cases due to Haemophilus influenzae at all ages. A fall in cases of meningococcal meningitis was significant in infants under 1 year of age only. Possible reasons for the change in the bacteriological pattern are discussed. PMID:2357086

Phase Diagram for Magnon Condensate in Yttrium Iron Garnet Film

PubMed Central

Li, Fuxiang; Saslow, Wayne M.; Pokrovsky, Valery L.

2013-01-01

Recently, magnons, which are quasiparticles describing the collective motion of spins, were found to undergo Bose-Einstein condensation (BEC) at room temperature in films of Yttrium Iron Garnet (YIG). Unlike other quasiparticle BEC systems, this system has a spectrum with two degenerate minima, which makes it possible for the system to have two condensates in momentum space. Recent Brillouin Light Scattering studies for a microwave-pumped YIG film of thickness d = 5 μm and field H = 1 kOe find a low-contrast interference pattern at the characteristic wavevector Q of the magnon energy minimum. In this report, we show that this modulation pattern can be quantitatively explained as due to unequal but coherent Bose-Einstein condensation of magnons into the two energy minima. Our theory predicts a transition from a high-contrast symmetric state to a low-contrast non-symmetric state on varying the d and H, and a new type of collective oscillation. PMID:23455849

Collective almost synchronisation in complex networks.

PubMed

Baptista, Murilo S; Ren, Hai-Peng; Swarts, Johen C M; Carareto, Rodrigo; Nijmeijer, Henk; Grebogi, Celso

2012-01-01

This work introduces the phenomenon of Collective Almost Synchronisation (CAS), which describes a universal way of how patterns can appear in complex networks for small coupling strengths. The CAS phenomenon appears due to the existence of an approximately constant local mean field and is characterised by having nodes with trajectories evolving around periodic stable orbits. Common notion based on statistical knowledge would lead one to interpret the appearance of a local constant mean field as a consequence of the fact that the behaviour of each node is not correlated to the behaviours of the others. Contrary to this common notion, we show that various well known weaker forms of synchronisation (almost, time-lag, phase synchronisation, and generalised synchronisation) appear as a result of the onset of an almost constant local mean field. If the memory is formed in a brain by minimising the coupling strength among neurons and maximising the number of possible patterns, then the CAS phenomenon is a plausible explanation for it.

Collective Almost Synchronisation in Complex Networks

PubMed Central

Baptista, Murilo S.; Ren, Hai-Peng; Swarts, Johen C. M.; Carareto, Rodrigo; Nijmeijer, Henk; Grebogi, Celso

2012-01-01

This work introduces the phenomenon of Collective Almost Synchronisation (CAS), which describes a universal way of how patterns can appear in complex networks for small coupling strengths. The CAS phenomenon appears due to the existence of an approximately constant local mean field and is characterised by having nodes with trajectories evolving around periodic stable orbits. Common notion based on statistical knowledge would lead one to interpret the appearance of a local constant mean field as a consequence of the fact that the behaviour of each node is not correlated to the behaviours of the others. Contrary to this common notion, we show that various well known weaker forms of synchronisation (almost, time-lag, phase synchronisation, and generalised synchronisation) appear as a result of the onset of an almost constant local mean field. If the memory is formed in a brain by minimising the coupling strength among neurons and maximising the number of possible patterns, then the CAS phenomenon is a plausible explanation for it. PMID:23144851

Turning Passive Brownian Motion Into Active Motion

NASA Astrophysics Data System (ADS)

Sevilla, Francisco J.; VáSquez-Arzola, Alejandro; Puga-Cital, Enrique

We consider out-of-equilibrium phenomena, specifically, the pattern of motion of active particles. These particles absorb energy from the environment and transform it into self-locomotion, generally, through complex mechanisms. Though the out-of-equilibrium nature of on the motion of these systems is well recognized, is generally difficult to pinpoint how far from equilibrium these systems are. In this work we elucidate the out-of-equilibrium nature of non-interacting, trapped, active particles, whose pattern of motion is described by a run-and-tumble dynamics. We show that the stationary distributions of these run-and-tumble particles, moving under the effects of an external potential, is equivalent to the stationary distribution of non-interacting, passive Brownian particles moving in the same potential but in an inhomogeneous source of heat. The interest in this topic has recently regrown due to the experimental possibility to design man-made active particles that emulate the ones that exist in the biological realm. F.J.S kindly acknowledges support from Grant UNAM-DGAPA-PAPIIT-IN113114.

Wet climate and transportation routes accelerate spread of human plague

PubMed Central

Xu, Lei; Stige, Leif Chr.; Kausrud, Kyrre Linné; Ben Ari, Tamara; Wang, Shuchun; Fang, Xiye; Schmid, Boris V.; Liu, Qiyong; Stenseth, Nils Chr.; Zhang, Zhibin

2014-01-01

Currently, large-scale transmissions of infectious diseases are becoming more closely associated with accelerated globalization and climate change, but quantitative analyses are still rare. By using an extensive dataset consisting of date and location of cases for the third plague pandemic from 1772 to 1964 in China and a novel method (nearest neighbour approach) which deals with both short- and long-distance transmissions, we found the presence of major roads, rivers and coastline accelerated the spread of plague and shaped the transmission patterns. We found that plague spread velocity was positively associated with wet conditions (measured by an index of drought and flood events) in China, probably due to flood-driven transmission by people or rodents. Our study provides new insights on transmission patterns and possible mechanisms behind variability in transmission speed, with implications for prevention and control measures. The methodology may also be applicable to studies of disease dynamics or species movement in other systems. PMID:24523275

Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study.

PubMed

Beheshti, Afshin; Cekanaviciute, Egle; Smith, David J; Costes, Sylvain V

2018-03-08

Spaceflight introduces a combination of environmental stressors, including microgravity, ionizing radiation, changes in diet and altered atmospheric gas composition. In order to understand the impact of each environmental component on astronauts it is important to investigate potential influences in isolation. Rodent spaceflight experiments involve both standard vivarium cages and animal enclosure modules (AEMs), which are cages used to house rodents in spaceflight. Ground control AEMs are engineered to match the spaceflight environment. There are limited studies examining the biological response invariably due to the configuration of AEM and vivarium housing. To investigate the innate global transcriptomic patterns of rodents housed in spaceflight-matched AEM compared to standard vivarium cages we utilized publicly available data from the NASA GeneLab repository. Using a systems biology approach, we observed that AEM housing was associated with significant transcriptomic differences, including reduced metabolism, altered immune responses, and activation of possible tumorigenic pathways. Although we did not perform any functional studies, our findings revealed a mild hypoxic phenotype in AEM, possibly due to atmospheric carbon dioxide that was increased to match conditions in spaceflight. Our investigation illustrates the process of generating new hypotheses and informing future experimental research by repurposing multiple space-flown datasets.

On the radiation beaming of bright X-ray pulsars and constraints on neutron star mass-radius relation

NASA Astrophysics Data System (ADS)

Mushtukov, Alexander A.; Verhagen, Patrick A.; Tsygankov, Sergey S.; van der Klis, Michiel; Lutovinov, Alexander A.; Larchenkova, Tatiana I.

2018-03-01

The luminosity of accreting magnetized neutron stars can largely exceed the Eddington value due to appearance of accretion columns. The height of the columns can be comparable to the neutron star radius. The columns produce the X-rays detected by the observer directly and illuminate the stellar surface, which reprocesses the X-rays and causes additional component of the observed flux. The geometry of the column and the illuminated part of the surface determine the radiation beaming. Curved space-time affects the angular flux distribution. We construct a simple model of the beam patterns formed by direct and reflected flux from the column. We take into account the possibility of appearance of accretion columns, whose height is comparable to the neutron star radius. We argue that depending on the compactness of the star, the flux from the column can be either strongly amplified due to gravitational lensing, or significantly reduced due to column eclipse by the star. The eclipses of high accretion columns result in specific features in pulse profiles. Their detection can put constraints on the neutron star radius. We speculate that column eclipses are observed in X-ray pulsar V 0332+53, leading us to the conclusion of large neutron star radius in this system (˜15 km if M ˜ 1.4 M⊙). We point out that the beam pattern can be strongly affected by scattering in the accretion channel at high luminosity, which has to be taken into account in the models reproducing the pulse profiles.

Relationship between women's occupational work and bone health: a study from India.

PubMed

Shatrugna, Veena; Kulkarni, Bharati; Kumar, P Ajay; Balakrishna, N; Rani, K Usha; Reddy, G Chennakrishna; Rao, G V Narasimha

2008-06-01

Physical activity is known to influence the bone mass of an individual. Few studies have examined the effect of occupational activities on bone health. The present study investigated the relationship between occupational activities and the bone parameters measured by dual-energy X-ray absorptiometry in 158 women from a low-income group in India. Women involved in three occupations with different bone-loading patterns (beedi (cigarette) makers, sweepers and construction workers) were included in the study. Anthropometric parameters, parity and percentage of menopausal women did not differ significantly between the three groups and dietary intake of Ca was low in all the groups. Bone mineral density (BMD) values of the overall group at all the sites were much lower than those reported from developed countries, possibly due to different body sizes in these regions. Femoral neck and hip BMD were not different in the three groups in spite of marked differences in activity patterns. However, bone area in the femoral neck was higher in the beedi makers compared with sweepers probably due to the squatting position adopted by beedi makers. Lumbar spine BMD was significantly lower among the sweepers when compared with the beedi makers and the groups performing walking and weight-bearing activities (sweepers and construction workers) had a higher prevalence of osteoporosis in the lumbar spine. However, weight-bearing effects of the upper body due to a squatting position were associated with better lumbar spine BMD in the beedi makers. The present study thus indicates that undernutrition might affect the relationship between occupational activities and bone parameters.

Masculine boys, feminine girls and cancer risk behaviors: An 11-year longitudinal study

PubMed Central

Roberts, Andrea L.; Rosario, Margaret; Calzo, Jerel P.; Corliss, Heather L.; Frazier, Lindsay; Austin, S. Bryn

2014-01-01

Objective Cancer risk behaviors often begin in adolescence and persist through adulthood. Tobacco use, indoor tanning, and physical inactivity are highly prevalent, socially patterned cancer risk behaviors, and their prevalence differs strongly by sex. It is therefore possible that these behaviors also differ by gender expression within the sexes due to social patterning. Methods We examined whether 5 cancer risk behaviors differed by childhood gender expression within the sexes and whether patterns of media engagement (e.g., magazine readership and trying to look like media personalities) explained possible differences, in a US population-based cohort (N=9,435). Results The most feminine girls had higher prevalence of indoor tanning (prevalence risk ratio (pRR)=1.32, 95% CI=1.23, 1.42) and physical inactivity (pRR=1.16, 95% CI=1.01, 1.34) and lower prevalence of worse smoking trajectory (prevalence odds ratio (pOR)=0.75, 95% CI=0.65, 0.88) and smoking cigars (pRR=0.61, 95% CI=0.47, 0.79) compared with least-feminine girls. Media engagement accounted for part of the higher prevalence of indoor tanning. The most masculine boys were more likely to chew tobacco (pRR=1.78, 95% CI=1.14, 2.79) and smoke cigars (pRR=1.55, 95% CI=1.17, 2.06), but less likely to follow a worse smoking trajectory (pOR=0.69, 95% CI=0.55, 0.87) and be physically inactive (pRR=0.54, 95% CI=0.43, 0.69) compared with least-masculine boys. Conclusions We found some strong differences in patterns of cancer risk behaviors by gender expression within the sexes. Prevention efforts that challenge the “masculinity” of smoking cigarettes and cigars and chewing tobacco and challenge the “femininity” of indoor tanning to reduce their appeal to adolescents should be explored. PMID:24746678

Masculine boys, feminine girls, and cancer risk behaviors: an 11-year longitudinal study.

PubMed

Roberts, Andrea L; Rosario, Margaret; Calzo, Jerel P; Corliss, Heather L; Frazier, Lindsay; Austin, S Bryn

2014-09-01

Cancer risk behaviors often begin in adolescence and persist through adulthood. Tobacco use, indoor tanning, and physical inactivity are highly prevalent, socially patterned cancer risk behaviors, and their prevalence differs strongly by sex. It is therefore possible that these behaviors also differ by gender expression within the sexes due to social patterning. We examined whether five cancer risk behaviors differed by childhood gender expression within the sexes and whether patterns of media engagement (e.g., magazine readership and trying to look like media personalities) explained possible differences, in a U.S. population-based cohort (N = 9,435). The most feminine girls had higher prevalence of indoor tanning (prevalence risk ratio [pRR] = 1.32, 95% confidence interval [CI] = 1.23-1.42) and physical inactivity (pRR = 1.16, 95% CI = 1.01-1.34) and lower prevalence of worse smoking trajectory (prevalence odds ratio = .75, 95% CI = .65-.88) and smoking cigars (pRR = .61, 95% CI = .47-.79) compared with least feminine girls. Media engagement accounted for part of the higher prevalence of indoor tanning. The most masculine boys were more likely to chew tobacco (pRR = 1.78, 95% CI = 1.14-2.79) and smoke cigars (pRR = 1.55, 95% CI = 1.17-2.06) but less likely to follow a worse smoking trajectory (prevalence odds ratio = .69, 95% CI = .55-.87) and be physically inactive (pRR = .54, 95% CI = .43-.69) compared with least masculine boys. We found some strong differences in patterns of cancer risk behaviors by gender expression within the sexes. Prevention efforts that challenge the "masculinity" of smoking cigarettes and cigars and chewing tobacco and the "femininity" of indoor tanning to reduce their appeal to adolescents should be explored. Copyright © 2014 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Enamel formation and growth in non-mammalian cynodonts

PubMed Central

Dirks, Wendy; Martinelli, Agustín G.

2018-01-01

The early evolution of mammals is associated with the linked evolutionary origin of diphyodont tooth replacement, rapid juvenile growth and determinate adult growth. However, specific relationships among these characters during non-mammalian cynodont evolution require further exploration. Here, polarized light microscopy revealed incremental lines, resembling daily laminations of extant mammals, in histological sections of enamel in eight non-mammalian cynodont species. In the more basal non-probainognathian group, enamel extends extremely rapidly from cusp to cervix. By contrast, the enamel of mammaliamorphs is gradually accreted, with slow rates of crown extension, more typical of the majority of non-hypsodont crown mammals. These results are consistent with the reduction in dental replacement rate across the non-mammalian cynodont lineage, with greater rates of crown extension required in most non-probainognathians, and slower crown extension rates permitted in mammaliamorphs, which have reduced patterns of dental replacement in comparison with many non-probainognathians. The evolution of mammal-like growth patterns, with faster juvenile growth and more abruptly terminating adult growth, is linked with this reduction in dental replacement rates and may provide an additional explanation for the observed pattern in enamel growth rates. It is possible that the reduction in enamel extension rates in mammaliamorphs reflects an underlying reduction in skeletal growth rates at the time of postcanine formation, due to a more abruptly terminating pattern of adult growth in these more mammal-like, crownward species. PMID:29892415

Using Lagrangian sampling to study water quality during downstream transport in the San Luis Drain, California, USA

USGS Publications Warehouse

Volkmar, E.C.; Dahlgren, R.A.; Stringfellow, W.T.; Henson, S.S.; Borglin, S.E.; Kendall, C.; Van Nieuwenhuyse, E. E.

2011-01-01

To investigate the mechanism for diel (24h) changes commonly observed at fixed sampling locations and how these diel changes relate to downstream transport in hypereutrophic surface waters, we studied a parcel of agricultural drainage water as it traveled for 84h in a concrete-lined channel having no additional water inputs or outputs. Algal fluorescence, dissolved oxygen, temperature, pH, conductivity, and turbidity were measured every 30min. Grab samples were collected every 2h for water quality analyses, including nutrients, suspended sediment, and chlorophyll/pheophytin. Strong diel patterns were observed for dissolved oxygen, pH, and temperature within the parcel of water. In contrast, algal pigments and nitrate did not exhibit diel patterns within the parcel of water, but did exhibit strong diel patterns for samples collected at a fixed sampling location. The diel patterns observed at fixed sampling locations for these constituents can be attributed to algal growth during the day and downstream transport (washout) of algae at night. Algal pigments showed a rapid daytime increase during the first 48h followed by a general decrease for the remainder of the study, possibly due to sedimentation and photobleaching. Algal growth (primarily diatoms) was apparent each day during the study, as measured by increasing dissolved oxygen concentrations, despite low phosphate concentrations (<0.01mgL-1). ?? 2011 Elsevier B.V.

Assessing global radiative forcing due to regional emissions of tropospheric ozone precursors: a step towards climate credit for ozone reductions

NASA Astrophysics Data System (ADS)

Mauzerall, D. L.; Naik, V.; Horowitz, L. W.; Schwarzkopf, D.; Ramaswamy, V.; Oppenheimer, M.

2005-05-01

Carbon dioxide emissions from fossil-fuel consumption are presented for the five Asian countries that are among the global leaders in anthropogenic carbon emissions: China (13% of global total), Japan (5% of global total), India (5% of global total), South Korea (2% of global total), and Indonesia (1% of global total). Together, these five countries represent over a quarter of the world's fossil-fuel based carbon emissions. Moreover, these countries are rapidly developing and energy demand has grown dramatically in the last two decades. A method is developed to estimate the spatial and seasonal flux of fossil-fuel consumption, thereby greatly improving the temporal and spatial resolution of anthropogenic carbon dioxide emissions. Currently, only national annual data for anthropogenic carbon emissions are available, and as such, no understanding of seasonal or sub-national patterns of emissions are possible. This methodology employs fuel distribution data from representative sectors of the fossil-fuel market to determine the temporal and spatial patterns of fuel consumption. These patterns of fuel consumption are then converted to patterns of carbon emissions. The annual total emissions estimates produced by this method are consistent to those maintained by the United Nations. Improved estimates of temporal and spatial resolution of the human based carbon emissions allows for better projections about future energy demands, carbon emissions, and ultimately the global carbon cycle.

Sodium butyrate improves the cloned yak embryo viability and corrects gene expression patterns.

PubMed

Xiong, Xian-rong; Lan, Dao-liang; Li, Jian; Wang, Yong; Zhong, Jin-cheng

2015-02-01

Interspecies somatic cell nuclear transfer (iSCNT), a powerful tool in basic scientific research, has been used widely to increase and preserve the population of endangered species. Yak (Bos grunniens) is one of these species. Development to term of interspecies cloned yak embryos has not been achieved, possibly due to abnormal epigenetic reprogramming. Previous studies have demonstrated that treatment of intraspecies cloned embryos with (NaBu) significantly improves nuclear-cytoplasmic reprogramming and viability in vitro. Therefore, in this study, we evaluated the effect of optimal NaBu concentration and exposure time on preimplantation development of yak iSCNT embryos and on the expression patterns of developmentally important genes. The results showed that 8-cell rate, blastocyst formation rate and total cell number increased significantly compared with their untreated counterparts when yak iSCNT embryos were treated with 5 nM NaBu for 12 h after activation, but that the 2-cell stage embryo rate was not significantly different. The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. The results described above indicated that NaBu treatment improved developmental competence in vitro and 'corrected' the gene expression patterns of yak iSCNT embryos.

Grieving experiences amongst adolescents orphaned by AIDS: Analysis from event history calendars.

PubMed

Thupayagale-Tshweneagae, Gloria

2012-09-07

Mental health is an essential component of adolescent health and wellbeing. Mental health practitioners assess adolescents' mental health status to identify possible issues that may lead to mental health problems. However, very few of the tools used to assess the mental health status of adolescents include assessment for grieving and coping patterns. The current tools used for assessing an individual's mental health are lengthy and not comprehensive. The purpose of this study was to assess grieving patterns of adolescents orphaned by AIDS and to appraise the usefulness of an event history calendar as an assessment tool for identifying grieving experiences, in order to guide and support these adolescents through the grieving process. One hundred and two adolescents aged 14-18 years, who had been orphaned by AIDS, completed an event history calendar, reviewed it with the researcher and reported their perceptions of it. Thematic analysis of the event history calendar content revealed that it is an effective, time-efficient, adolescent-friendly tool that facilitated identification and discussion of the orphaned adolescents' grieving patterns. Crying, isolation, silence and violent outbursts were the main grieving patterns reported by adolescents orphaned by AIDS. The researcher recommends use of the event history calendar for identification of orphaned adolescents' grieving experiences. Early identification would enable mental health practitioners to support them in order to prevent the occurrence of mental illness due to maladaptive grieving.

Using pattern analysis methods to do fast detection of manufacturing pattern failures

NASA Astrophysics Data System (ADS)

Zhao, Evan; Wang, Jessie; Sun, Mason; Wang, Jeff; Zhang, Yifan; Sweis, Jason; Lai, Ya-Chieh; Ding, Hua

2016-03-01

At the advanced technology node, logic design has become extremely complex and is getting more challenging as the pattern geometry size decreases. The small sizes of layout patterns are becoming very sensitive to process variations. Meanwhile, the high pressure of yield ramp is always there due to time-to-market competition. The company that achieves patterning maturity earlier than others will have a great advantage and a better chance to realize maximum profit margins. For debugging silicon failures, DFT diagnostics can identify which nets or cells caused the yield loss. But normally, a long time period is needed with many resources to identify which failures are due to one common layout pattern or structure. This paper will present a new yield diagnostic flow, based on preliminary EFA results, to show how pattern analysis can more efficiently detect pattern related systematic defects. Increased visibility on design pattern related failures also allows more precise yield loss estimation.

An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks.

PubMed

He, Jieyue; Wang, Chunyan; Qiu, Kunpu; Zhong, Wei

2014-01-01

Motif mining has always been a hot research topic in bioinformatics. Most of current research on biological networks focuses on exact motif mining. However, due to the inevitable experimental error and noisy data, biological network data represented as the probability model could better reflect the authenticity and biological significance, therefore, it is more biological meaningful to discover probability motif in uncertain biological networks. One of the key steps in probability motif mining is frequent pattern discovery which is usually based on the possible world model having a relatively high computational complexity. In this paper, we present a novel method for detecting frequent probability patterns based on circuit simulation in the uncertain biological networks. First, the partition based efficient search is applied to the non-tree like subgraph mining where the probability of occurrence in random networks is small. Then, an algorithm of probability isomorphic based on circuit simulation is proposed. The probability isomorphic combines the analysis of circuit topology structure with related physical properties of voltage in order to evaluate the probability isomorphism between probability subgraphs. The circuit simulation based probability isomorphic can avoid using traditional possible world model. Finally, based on the algorithm of probability subgraph isomorphism, two-step hierarchical clustering method is used to cluster subgraphs, and discover frequent probability patterns from the clusters. The experiment results on data sets of the Protein-Protein Interaction (PPI) networks and the transcriptional regulatory networks of E. coli and S. cerevisiae show that the proposed method can efficiently discover the frequent probability subgraphs. The discovered subgraphs in our study contain all probability motifs reported in the experiments published in other related papers. The algorithm of probability graph isomorphism evaluation based on circuit simulation method excludes most of subgraphs which are not probability isomorphism and reduces the search space of the probability isomorphism subgraphs using the mismatch values in the node voltage set. It is an innovative way to find the frequent probability patterns, which can be efficiently applied to probability motif discovery problems in the further studies.

An novel frequent probability pattern mining algorithm based on circuit simulation method in uncertain biological networks

PubMed Central

2014-01-01

Background Motif mining has always been a hot research topic in bioinformatics. Most of current research on biological networks focuses on exact motif mining. However, due to the inevitable experimental error and noisy data, biological network data represented as the probability model could better reflect the authenticity and biological significance, therefore, it is more biological meaningful to discover probability motif in uncertain biological networks. One of the key steps in probability motif mining is frequent pattern discovery which is usually based on the possible world model having a relatively high computational complexity. Methods In this paper, we present a novel method for detecting frequent probability patterns based on circuit simulation in the uncertain biological networks. First, the partition based efficient search is applied to the non-tree like subgraph mining where the probability of occurrence in random networks is small. Then, an algorithm of probability isomorphic based on circuit simulation is proposed. The probability isomorphic combines the analysis of circuit topology structure with related physical properties of voltage in order to evaluate the probability isomorphism between probability subgraphs. The circuit simulation based probability isomorphic can avoid using traditional possible world model. Finally, based on the algorithm of probability subgraph isomorphism, two-step hierarchical clustering method is used to cluster subgraphs, and discover frequent probability patterns from the clusters. Results The experiment results on data sets of the Protein-Protein Interaction (PPI) networks and the transcriptional regulatory networks of E. coli and S. cerevisiae show that the proposed method can efficiently discover the frequent probability subgraphs. The discovered subgraphs in our study contain all probability motifs reported in the experiments published in other related papers. Conclusions The algorithm of probability graph isomorphism evaluation based on circuit simulation method excludes most of subgraphs which are not probability isomorphism and reduces the search space of the probability isomorphism subgraphs using the mismatch values in the node voltage set. It is an innovative way to find the frequent probability patterns, which can be efficiently applied to probability motif discovery problems in the further studies. PMID:25350277

Post-OPC verification using a full-chip pattern-based simulation verification method

NASA Astrophysics Data System (ADS)

Hung, Chi-Yuan; Wang, Ching-Heng; Ma, Cliff; Zhang, Gary

2005-11-01

In this paper, we evaluated and investigated techniques for performing fast full-chip post-OPC verification using a commercial product platform. A number of databases from several technology nodes, i.e. 0.13um, 0.11um and 90nm are used in the investigation. Although it has proven that for most cases, our OPC technology is robust in general, due to the variety of tape-outs with complicated design styles and technologies, it is difficult to develop a "complete or bullet-proof" OPC algorithm that would cover every possible layout patterns. In the evaluation, among dozens of databases, some OPC databases were found errors by Model-based post-OPC checking, which could cost significantly in manufacturing - reticle, wafer process, and more importantly the production delay. From such a full-chip OPC database verification, we have learned that optimizing OPC models and recipes on a limited set of test chip designs may not provide sufficient coverage across the range of designs to be produced in the process. And, fatal errors (such as pinch or bridge) or poor CD distribution and process-sensitive patterns may still occur. As a result, more than one reticle tape-out cycle is not uncommon to prove models and recipes that approach the center of process for a range of designs. So, we will describe a full-chip pattern-based simulation verification flow serves both OPC model and recipe development as well as post OPC verification after production release of the OPC. Lastly, we will discuss the differentiation of the new pattern-based and conventional edge-based verification tools and summarize the advantages of our new tool and methodology: 1). Accuracy: Superior inspection algorithms, down to 1nm accuracy with the new "pattern based" approach 2). High speed performance: Pattern-centric algorithms to give best full-chip inspection efficiency 3). Powerful analysis capability: Flexible error distribution, grouping, interactive viewing and hierarchical pattern extraction to narrow down to unique patterns/cells.

Association of salivary cortisol with chronomics of 24 hours ambulatory blood pressure/heart rate among night shift workers.

PubMed

Anjum, B; Verma, N S; Tiwari, S; Singh, R; Mahdi, A A; Singh, R B; Singh, R K

2011-08-01

Recent studies indicate a circadian rhythm in blood pressure and heart rate and its association with various neurotransmitters. In the present study, we examine the circadian nature of blood pressure/heart rate and salivary cortisol in night shift workers and whether these circadian changes produced by night shifts are reversible. Sixteen healthy nurses of both genders, aged 20-40 years, performing day and night shift duties, were randomly selected out of 22 who volunteered for this study. Ambulatory blood pressure monitoring was done in all the subjects and salivary cortisol levels were analyzed during both day and night shift duties. There were clinically significant changes in the Acrophase of blood pressure and cortisol levels, indicating ecphasia (odd timing of systolic blood pressure) individually during night as well as day shifts. However, this pattern was statistically not significant. A reverse pattern of Acrophase was observed in 8 out of 16 subjects when they were posted on day shift. No significant change was found in midline estimating statistics of rhythm (MESOR) of blood pressure values. Changes in Double amplitude (Predictable change) were observed in 8 subjects during night shifts as well as in 7 subjects during day shifts. However, the pattern was not similar and night workers had an altered circadian pattern in the night as well as during day shifts. Changes in Double amplitude, Acrophase and Salivary cortisol were found during night as well as day shifts but these changes were not statistically significant (p > 0.05) due to incomplete recovery during day shifts (changes again seen when they came back to day shifts). Salivary cortisol levels were lowest in early morning, increased at midnight and further increased in the afternoon during night shifts along with ecphasia. It is possible that nurses working the night shift felt more tired due to the altered circadian cycle.

Pyro-electrification of polymer membranes for cell patterning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rega, R.; Gennari, O.; Mecozzia, L.

2016-05-18

In the recent years, much attention has been devoted to the possibility of charging polymer-based materials, due to their potential in developing large-scale and inexpensive flexible thin-film technology. The availability of localized electrostatic fields is in of great interest for a huge amount of applications such as distribution of biomolecules and cells from the liquid phase. Here we report a voltage-free pyro-electrification (PE) process able to induce permanent dipoles into polymer layers; the lithium niobate (LN) crystal is the key component that plays the multi-purpose role of sustaining, heating and poling the polymer layer that is then peeled-off easily inmore » order to have a free-standing charged membrane. The results show the fascinating application for the living cell patterning. It well known that cell behaviour is affected by chemical and topographical cues of substrate. In fact, polymers, such as polystyrene (PS) and poly(methyl methacrylate) (PMMA), are naturally cytophobic and require specific functionalization treatments in order to promote cell adhesion. Through our proposal technique, it’s possible to obtain spontaneous organization and a driven growth of SH-SY5Y cells that is solely dictated by the nature of the charge polymer surface, opening, in this way, the innovative chance to manipulate and transfer biological samples on a free-standing polymer layer [1].« less

Design of a variable width pulse generator feasible for manual or automatic control

NASA Astrophysics Data System (ADS)

Vegas, I.; Antoranz, P.; Miranda, J. M.; Franco, F. J.

2017-01-01

A variable width pulse generator featuring more than 4-V peak amplitude and less than 10-ns FWHM is described. In this design the width of the pulses is controlled by means of the control signal slope. Thus, a variable transition time control circuit (TTCC) is also developed, based on the charge and discharge of a capacitor by means of two tunable current sources. Additionally, it is possible to activate/deactivate the pulses when required, therefore allowing the creation of any desired pulse pattern. Furthermore, the implementation presented here can be electronically controlled. In conclusion, due to its versatility, compactness and low cost it can be used in a wide variety of applications.

Algorithm of pulmonary emphysema extraction using thoracic 3D CT images

NASA Astrophysics Data System (ADS)

Saita, Shinsuke; Kubo, Mitsuru; Kawata, Yoshiki; Niki, Noboru; Nakano, Yasutaka; Ohmatsu, Hironobu; Tominaga, Keigo; Eguchi, Kenji; Moriyama, Noriyuki

2007-03-01

Recently, due to aging and smoking, emphysema patients are increasing. The restoration of alveolus which was destroyed by emphysema is not possible, thus early detection of emphysema is desired. We describe a quantitative algorithm for extracting emphysematous lesions and quantitatively evaluate their distribution patterns using low dose thoracic 3-D CT images. The algorithm identified lung anatomies, and extracted low attenuation area (LAA) as emphysematous lesion candidates. Applying the algorithm to thoracic 3-D CT images and then by follow-up 3-D CT images, we demonstrate its potential effectiveness to assist radiologists and physicians to quantitatively evaluate the emphysematous lesions distribution and their evolution in time interval changes.

Algorithm of pulmonary emphysema extraction using low dose thoracic 3D CT images

NASA Astrophysics Data System (ADS)

Saita, S.; Kubo, M.; Kawata, Y.; Niki, N.; Nakano, Y.; Omatsu, H.; Tominaga, K.; Eguchi, K.; Moriyama, N.

2006-03-01

Recently, due to aging and smoking, emphysema patients are increasing. The restoration of alveolus which was destroyed by emphysema is not possible, thus early detection of emphysema is desired. We describe a quantitative algorithm for extracting emphysematous lesions and quantitatively evaluate their distribution patterns using low dose thoracic 3-D CT images. The algorithm identified lung anatomies, and extracted low attenuation area (LAA) as emphysematous lesion candidates. Applying the algorithm to 100 thoracic 3-D CT images and then by follow-up 3-D CT images, we demonstrate its potential effectiveness to assist radiologists and physicians to quantitatively evaluate the emphysematous lesions distribution and their evolution in time interval changes.

How to keep your pants on: historic metamaterials and elasticity before the invention of elastic

NASA Astrophysics Data System (ADS)

Matsumoto, Elisabetta A.; Mahadevan, L.

2015-03-01

How do you create stretching from an inextensible material? Remarkably, the centuries-old embroidery technique known as smocking accomplishes just this. With the recent explosion of origami-based engineering, the search is on for a set of design principles to generate materials with prescribed mechanical properties. This quickly becomes a complex mathematical question due to the strict constraints of rigid origami imposed by the inextensibility of paper. Softening these constraints by considering woven fabrics, which have two orthogonal inextensible directions and a skewed soft shear mode, opens up a zoo of possible configurations. We explore the emergence of elastic properties in smocked fabrics as functions of both fabric elasticity and smocking pattern.

Constructing molecular structures on periodic superstructure of graphene/Ru(0001)

PubMed Central

Li, Geng; Huang, Li; Xu, Wenyan; Que, Yande; Zhang, Yi; Lu, Jianchen; Du, Shixuan; Liu, Yunqi; Gao, Hong-Jun

2014-01-01

We review the way to fabricate large-scale, high-quality and single crystalline graphene epitaxially grown on Ru(0001) substrate. A moiré pattern of the graphene/Ru(0001) is formed due to the lattice mismatch between graphene and Ru(0001). This superstructure gives rise to surface charge redistribution and could behave as an ordered quantum dot array, which results in a perfect template to guide the assembly of organic molecular structures. Molecules, for example iron phthalocyanine and C60, on this template show how the molecule–substrate interaction makes different superstructures. These results show the possibility of constructing ordered molecular structures on graphene/Ru(0001), which is helpful for practical applications in the future. PMID:24615151

Transcriptional expression analysis of genes involved in regulation of calcium translocation and storage in finger millet (Eleusine coracana L. Gartn.).

PubMed

Mirza, Neelofar; Taj, Gohar; Arora, Sandeep; Kumar, Anil

2014-10-25

Finger millet (Eleusine coracana) variably accumulates calcium in different tissues, due to differential expression of genes involved in uptake, translocation and accumulation of calcium. Ca(2+)/H(+) antiporter (CAX1), two pore channel (TPC1), CaM-stimulated type IIB Ca(2+) ATPase and two CaM dependent protein kinase (CaMK1 and 2) homologs were studied in finger millet. Two genotypes GP-45 and GP-1 (high and low calcium accumulating, respectively) were used to understand the role of these genes in differential calcium accumulation. For most of the genes higher expression was found in the high calcium accumulating genotype. CAX1 was strongly expressed in the late stages of spike development and could be responsible for accumulating high concentrations of calcium in seeds. TPC1 and Ca(2+) ATPase homologs recorded strong expression in the root, stem and developing spike and signify their role in calcium uptake and translocation, respectively. Calmodulin showed strong expression and a similar expression pattern to the type IIB ATPase in the developing spike only and indicating developing spike or even seed specific isoform of CaM affecting the activity of downstream target of calcium transportation. Interestingly, CaMK1 and CaMK2 had expression patterns similar to ATPase and TPC1 in various tissues raising a possibility of their respective regulation via CaM kinase. Expression pattern of 14-3-3 gene was observed to be similar to CAX1 gene in leaf and developing spike inferring a surprising possibility of CAX1 regulation through 14-3-3 protein. Our results provide a molecular insight for explaining the mechanism of calcium accumulation in finger millet. Copyright © 2014 Elsevier B.V. All rights reserved.

Weather-forced variations of Central and East Pacific ENSO events

NASA Astrophysics Data System (ADS)

Alexander, M. A.; Newman, M.; Shin, S.

2010-12-01

It has been suggested that a possible outcome of climate change is an increase in the occurrence of “Modoki” or central Pacific El Nino events relative to canonical eastern Pacific El Nino events, and that this change may already be occurring. Such a determination, however, is complicated by possible natural variations of the two types of events. How large a change in the relative occurrence can be expected from purely internal variability? To explore this question, a “patterns-based” red noise null hypothesis is constructed from 40 years of observed seasonally-averaged SST, 20 deg C thermocline depth, and surface zonal wind stress anomalies. Patterns-based (or multivariate) red noise differs from “local” (or univariate) red noise since it allows for non-local advective processes; for example, weather noise driving surface wind stress in one location to produce an ocean response in a different location. It is shown that natural random variations of the central Pacific to east Pacific El Nino occurrence ratio are large enough that they could account for all past observed differences as well as all differences found in the SRESA1B runs of all AR4 climate models. Additionally, the correlation between Nino3 and Nino4 SST indices over 30-yr periods can range between 0.7 and 0.9 simply due to such variations in noise, with apparent multidecadal “trends” during which the value increases or decreases. Further analysis shows the different spatial patterns of “noise” (i.e., random weather forcing) that can lead to the development of central vs. eastern Pacific ENSO events or various combinations thereof.

Patterns and Possibilities: Exploring Religious Education in the Catholic Secondary School (Dayton, Ohio, 1995).

ERIC Educational Resources Information Center

Heft, James; Groome, Thomas; Taymans, Mary Frances, Ed.; Lund, Lars

Drawing on presentations and informal discussions from a gathering at the University of Dayton (Ohio) in 1995, this book examines Catholic secondary education and campus ministry. Following a foreword by Mary Frances Taymans, the booklet includes three essays: "Patterns and Possibilities" (James Heft); "Conversation as a Mode of…

An Autonomous Star Identification Algorithm Based on One-Dimensional Vector Pattern for Star Sensors

PubMed Central

Luo, Liyan; Xu, Luping; Zhang, Hua

2015-01-01

In order to enhance the robustness and accelerate the recognition speed of star identification, an autonomous star identification algorithm for star sensors is proposed based on the one-dimensional vector pattern (one_DVP). In the proposed algorithm, the space geometry information of the observed stars is used to form the one-dimensional vector pattern of the observed star. The one-dimensional vector pattern of the same observed star remains unchanged when the stellar image rotates, so the problem of star identification is simplified as the comparison of the two feature vectors. The one-dimensional vector pattern is adopted to build the feature vector of the star pattern, which makes it possible to identify the observed stars robustly. The characteristics of the feature vector and the proposed search strategy for the matching pattern make it possible to achieve the recognition result as quickly as possible. The simulation results demonstrate that the proposed algorithm can effectively accelerate the star identification. Moreover, the recognition accuracy and robustness by the proposed algorithm are better than those by the pyramid algorithm, the modified grid algorithm, and the LPT algorithm. The theoretical analysis and experimental results show that the proposed algorithm outperforms the other three star identification algorithms. PMID:26198233

An Autonomous Star Identification Algorithm Based on One-Dimensional Vector Pattern for Star Sensors.

PubMed

Luo, Liyan; Xu, Luping; Zhang, Hua

2015-07-07

In order to enhance the robustness and accelerate the recognition speed of star identification, an autonomous star identification algorithm for star sensors is proposed based on the one-dimensional vector pattern (one_DVP). In the proposed algorithm, the space geometry information of the observed stars is used to form the one-dimensional vector pattern of the observed star. The one-dimensional vector pattern of the same observed star remains unchanged when the stellar image rotates, so the problem of star identification is simplified as the comparison of the two feature vectors. The one-dimensional vector pattern is adopted to build the feature vector of the star pattern, which makes it possible to identify the observed stars robustly. The characteristics of the feature vector and the proposed search strategy for the matching pattern make it possible to achieve the recognition result as quickly as possible. The simulation results demonstrate that the proposed algorithm can effectively accelerate the star identification. Moreover, the recognition accuracy and robustness by the proposed algorithm are better than those by the pyramid algorithm, the modified grid algorithm, and the LPT algorithm. The theoretical analysis and experimental results show that the proposed algorithm outperforms the other three star identification algorithms.

From Local Adaptation to Ecological Speciation in Copepod Populations from Neighboring Lakes

PubMed Central

Barrera-Moreno, Omar Alfredo; Ciros-Pérez, Jorge; Ortega-Mayagoitia, Elizabeth; Alcántara-Rodríguez, José Arturo; Piedra-Ibarra, Elías

2015-01-01

Continental copepods have been derived from several independent invasive events from the sea, but the subsequent evolutionary processes that account for the current diversity in lacustrine environments are virtually unknown. Salinity is highly variable among lakes and constitutes a source of divergent selection driving potential reproductive isolation. We studied four populations of the calanoid copepod Leptodiaptomus cf. sicilis inhabiting four neighboring lakes with a common history (since the Late Pleistocene) located in the Oriental Basin, Mexico; one lake is shallow and varies in salinity periodically (1.4–10 g L-1), while three are deep and permanent, with constant salinity (0.5, 1.1 and 6.5 g L-1, respectively). We hypothesized that (1) these populations belong to a different species than L. sicilis sensu stricto and (2) are experiencing ecologically based divergence due to salinity differences. We assessed morphological and molecular (mtDNA) COI variation, as well as fitness differences and tests of reproductive isolation. Although relationships of the Mexican populations with L. sicilis s.s. could not be elucidated, we identified a clear pattern of divergent selection driven by salinity conditions. The four populations can still be considered a single biological species (sexual recognition and hybridization are still possible in laboratory conditions), but they have diverged into at least three different phenotypes: two locally adapted, specialized in the lakes of constant salinity (saline vs. freshwater), and an intermediate generalist phenotype inhabiting the temporary lake with fluctuating salinity. The specialized phenotypes are poorly suited as migrants, so prezygotic isolation due to immigrant inviability is highly probable. This implication was supported by molecular evidence that showed restricted gene flow, persistence of founder events, and a pattern of allopatric fragmentation. This study showed how ecologically based divergent selection may explain diversification patterns in lacustrine copepods. PMID:25915059

A Longitudinal Study on Feeding Behaviour and Activity Patterns of Released Chimpanzees in Conkouati-Douli National Park, Republic of Congo

PubMed Central

Renaud, Amandine; Jamart, Aliette; Goossens, Benoit; Ross, Caroline

2013-01-01

Simple Summary Wild chimpanzee populations are dramatically declining due to anthropogenic pressure. One way of increasing wild population numbers and/or repopulating areas where local extinction has occurred is to release captive animals. HELP Congo was the first project to successfully release wild-born orphan chimpanzees in their natural environment. We studied the behaviour of eight released chimpanzees over eight years. Over time, they modified their behaviour, suggesting long-term behavioural and ecological adaptations. This suggests that successful release programmes may reinforce existing populations of endangered species. Abstract Wild chimpanzee populations are still declining due to logging, disease transmission and hunting. The bushmeat trade frequently leads to an increase in the number of orphaned primates. HELP Congo was the first project to successfully release wild-born orphan chimpanzees into an existing chimpanzee habitat. A collection of post monitoring data over 16 years now offers the unique opportunity to investigate possible behavioural adaptations in these chimpanzees. We investigated the feeding and activity patterns in eight individuals via focal observation techniques from 1997–1999 and 2001–2005. Our results revealed a decline in the number of fruit and insect species in the diet of released chimpanzees over the years, whereas within the same period of time, the number of consumed seed species increased. Furthermore, we found a decline in time spent travelling, but an increase in time spent on social activities, such as grooming, as individuals matured. In conclusion, the observed changes in feeding and activity patterns seem to reflect important long-term behavioural and ecological adaptations in wild-born orphan released chimpanzees, demonstrating that the release of chimpanzees can be successful, even if it takes time for full adaptation. PMID:26487416

Modeling of Instabilities and Self-organization at the Frictional Interface

NASA Astrophysics Data System (ADS)

Mortazavi, Vahid

The field of friction-induced self-organization and its practical importance remains unknown territory to many tribologists. Friction is usually thought of as irreversible dissipation of energy and deterioration; however, under certain conditions, friction can lead to the formation of new structures at the interface, including in-situ tribofilms and various patterns at the interface. This thesis studies self-organization and instabilities at the frictional interface, including the instability due to the temperature-dependency of the coefficient of friction, the transient process of frictional running-in, frictional Turing systems, the stick-and-slip phenomenon, and, finally, contact angle (CA) hysteresis as an example of solid-liquid friction and dissipation. All these problems are chosen to bridge the gap between fundamental interest in understanding the conditions leading to self-organization and practical motivation. We study the relationship between friction-induced instabilities and friction-induced self-organization. Friction is usually thought of as a stabilizing factor; however, sometimes it leads to the instability of sliding, in particular when friction is coupled with another process. Instabilities constitute the main mechanism for pattern formation. At first, a stationary structure loses its stability; after that, vibrations with increasing amplitude occur, leading to a limit cycle corresponding to a periodic pattern. The self-organization is usually beneficial for friction and wear reduction because the tribological systems tend to enter a state with the lowest energy dissipation. The introductory chapter starts with basic definitions related to self-organization, instabilities and friction, literature review, and objectives. We discuss fundamental concepts that provide a methodological tool to investigate, understand and enhance beneficial processes in tribosystems which might lead to self-organization. These processes could result in the ability of a frictional surface to exhibit "self-protection" and "self-healing" properties. Hence, this research is dealing with the fundamental concepts that allow the possibility of the development of a new generation of tribosystem and materials that reinforce such properties. In chapter 2, we investigate instabilities due to the temperature-dependency of the coefficient of friction. The temperature-dependency of the coefficient of friction can have a significant effect on the frictional sliding stability, by leading to the formation of "hot" and "cold" spots on the contacting surfaces. We formulate a stability criterion and perform a case study of a brake disk. In chapter 3, we study frictional running-in. Running-in is a transient period on the onset of the frictional sliding, in which friction and wear decrease to their stationary values. In this research, running-in is interpreted as friction-induced self-organization process. We introduce a theoretical model of running-in and investigate rough profile evolution assuming that its kinetics is driven by two opposite processes or events, i.e., smoothening which is typical for the deformation-driven friction and wear, and roughening which is typical for the adhesion-driven friction and wear. In chapter 4, we investigate the possibility of the so-called Turing-type pattern formation during friction. Turing or reaction-diffusion systems describe variations of spatial concentrations of chemical components with time due to local chemical reactions coupled with diffusion. During friction, the patterns can form at the sliding interface due to the mass transfer (diffusion), heat transfer, various tribochemical reactions, and wear. In chapter 5, we investigate how interfacial patterns including propagating trains of stick and slip zones form due to dynamic sliding instabilities. These can be categorized as self-organized patterns. We treat stick and slip as two phases at the interface, and study the effects related to phase transitions. Our results show how interfacial patterns form, how the transition between stick and slip zones occurs, and which parameters affect them. In chapter 6, we use Cellular Potts Model to study contact angle (CA) hysteresis as a measure of solid-liquid energy dissipation. We simulate CA hysteresis for a droplet over the tilted patterned surface, and a bubble placed under the surface immersed in liquid. We discuss the dependency of CA hysteresis on the surface structure and other parameters. This analysis allows decoupling of the 1D (pinning of the triple line) and 2D effects (adhesion hysteresis in the contact area) and obtain new insights on the nature of CA hysteresis. To summarize, we examine different cases in frictional interface and observe similar trends. We investigate and discus how these trends could be beneficial in design, synthesis and characterization of different materials and tribosystems. Furthermore, we describe how to utilize fundamental concepts for specific engineering applications. Finally, the main theme of this research is to find new applications of concept of self-organization to tribology and the role played by different physical and chemical interactions in modifying and controlling friction and wear. (Abstract shortened by UMI.)

Soil cover patterns and SOC dynamics impacts on the soil processes, land management and ecosystem services in Central Region of Russia

NASA Astrophysics Data System (ADS)

Vasenev, Ivan; Chernikov, Vladimir; Yashin, Ivan; Geraskin, Mikhail; Morev, Dmitriy

2014-05-01

In the Central Region of Russia (CRR) the soil cover patterns usually play the very important role in the soil forming and degradation processes (SFP & SDP) potential and current rates, soil organic carbon (SOC) dynamics and pools, greenhouse gases (GHG) emissions and soluble SOC fluxes that we need take into attention for better assessment of the natural and especially man-changed ecosystems' services and for best land-use practices development. Central Region of Russia is the biggest one in RF according to its population and role in the economy. CRR is characterized by high spatial variability of soil cover due to as original landscape heterogeneity as complicated history of land-use practices during last 700 years. Our long-term researches include the wide zonal-provincial set of representative ecosystems and soil cover patterns with different types and history of land-use (forest, meadow-steppe and agricultural ones) from middle-taiga to steppe zones with different level of continentality. The carried out more than 30-years region- and local-scale researches of representative natural and rural landscapes in Tver', Yaroslavl', Kaluga, Moscow, Vladimir, Saransk (Mordovia), Kursk, Orel, Tambov, Voronezh and Saratov oblasts give us the interregional multi-factorial matrix of elementary soil cover patterns (ESCP) with different soil forming and degradation processes rates and soil organic carbon dynamics due to regionally specific soil-geomorphologic features, environmental and dominated microclimate conditions, land-use current practices and history. The validation and ranging of the limiting factors of SFP and SDP develop¬ment, soil carbon dynamics and sequestration potential, ecosystem (agroecosystem) principal services, land functional qualities and agroecological state have been done for dominating and most dynamical components of ESCP regional-typological forms - with application of SOC structure analysis, regional and local GIS, soil spatial patterns detail mapping, traditional regression kriging, correlation tree models and DSS adapted to concrete region and agrolandscape conditions. The outcomes of statistical process modeling show the essential amplification of erosion, dehumification, CO2, CH4 and N2O emission, soluble SOC fluxes, acidification or alkalization, disaggregation and overcompaction processes due to violation of environmentally sound land-use systems and traditional balances of organic matter, nutrients, Ca and Na in agrolandscapes. Due to long-term intensive and out-of-balance land-use practices the most zonal soils and soil cover pattern essentially lost not only their unique natural features (humus horizons depth till 1 m and more in case of Chernozems, 2-6 % of SOC and favorable agrophysical features), but ecosystem services and ecological functions including terrestrial ecosystem carbon balance and the GHG fluxes control. Key-site monitoring results and regional generalized data showed 1-1.5% SOC lost during last 50 years period and active processes of CO2 emission and humus profile eluvial-illuvial redistribution too. A drop of Corg content below threshold "humus limiting content" values (for different soils they vary from 1 to 3-4% of SOC) considerably reduces effectiveness of used fertilizers and possibility of sustai¬nable agronomy here. Forest-steppe Chernozems are usually characterized by higher stability than steppe ones. The ratio between erosive and biological losses in humus supplies can be ten-tatively estimated as fifty-fifty with strong spatial variability due to slope and land-use parameters. These processes have essentially different sets of environmental consequences and ecosystem services that we need to understand in frame of environmental and agroecological problems development prediction.

Evolutionary stasis in pollen morphogenesis due to natural selection.

PubMed

Matamoro-Vidal, Alexis; Prieu, Charlotte; Furness, Carol A; Albert, Béatrice; Gouyon, Pierre-Henri

2016-01-01

The contribution of developmental constraints and selective forces to the determination of evolutionary patterns is an important and unsolved question. We test whether the long-term evolutionary stasis observed for pollen morphogenesis (microsporogenesis) in eudicots is due to developmental constraints or to selection on a morphological trait shaped by microsporogenesis: the equatorial aperture pattern. Most eudicots have three equatorial apertures but several taxa have independently lost the equatorial pattern and have microsporogenesis decoupled from aperture pattern determination. If selection on the equatorial pattern limits variation, we expect to see increased variation in microsporogenesis in the nonequatorial clades. Variation of microsporogenesis was studied using phylogenetic comparative analyses in 83 species dispersed throughout eudicots including species with and without equatorial apertures. The species that have lost the equatorial pattern have highly variable microsporogenesis at the intra-individual and inter-specific levels regardless of their pollen morphology, whereas microsporogenesis remains stable in species with the equatorial pattern. The observed burst of variation upon loss of equatorial apertures shows that there are no strong developmental constraints precluding variation in microsporogenesis, and that the stasis is likely to be due principally to selective pressure acting on pollen morphogenesis because of its implication in the determination of the equatorial aperture pattern. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Streamflow and sediment dynamics of the Middle Rio Grande Valley, New Mexico, in the context of cottonwood recruitment

USGS Publications Warehouse

Milhous, Robert T.; Wondzell, Mark; Ritter, Amy

1993-01-01

The cottonwood gallery forests of the Middle Rio Grande floodplain in New Mexico provide important habitats for birds and other animals. Over the last century, these forests have changed significantly due to invasion of exotics such as salt cedar and Russian olive, which compete with native cottonwoods, and changes in water use both in the valley and upstream. To successfully germinate and establish, cottonwoods require an adequate water supply, abundant sunlight, and bare, litter-free substrate. Native cottonwoods are adapted to a natural snowmelt hydrograph characterized by spring floods in late May or early June and gradually receding streamflows throughout the remainder of the summer. The natural streamflow pattern has been significantly modified by water management in the Rio Grande basin. The modified pattern is less conducive to establishment of cottonwoods than the natural pattern. In addition, exotic species now compete with native cottonwoods, and the modified flow pattern may favor these exotics. The overall objective of this study was to investigate the possibility of enhancing cottonwood establishment and recruitment along the Middle Rio Grande through streamflow manipulation and reservoir releases. The work integrates concepts of cottonwood establishment, water resources management, and river morphology, and investigates how water management might be used to preserve and enhance cottonwood gallery forests along the river. Specific objectives of the work reported herein were to: (1) develop a technique to calculate flows that will produce channel characteristics necessary to restore and sustain cottonwood gallery forests; (2) develop a model to determine a flow pattern, or sequence of flows, that will improve the potential for cottonwood establishment and recruitment; and (3) determine if the water resources can be managed to produce the desired channel characteristics and flow pattern identified in (1) and (2).

Unsupervised discrimination of patterns in spiking neural networks with excitatory and inhibitory synaptic plasticity

PubMed Central

Srinivasa, Narayan; Cho, Youngkwan

2014-01-01

A spiking neural network model is described for learning to discriminate among spatial patterns in an unsupervised manner. The network anatomy consists of source neurons that are activated by external inputs, a reservoir that resembles a generic cortical layer with an excitatory-inhibitory (EI) network and a sink layer of neurons for readout. Synaptic plasticity in the form of STDP is imposed on all the excitatory and inhibitory synapses at all times. While long-term excitatory STDP enables sparse and efficient learning of the salient features in inputs, inhibitory STDP enables this learning to be stable by establishing a balance between excitatory and inhibitory currents at each neuron in the network. The synaptic weights between source and reservoir neurons form a basis set for the input patterns. The neural trajectories generated in the reservoir due to input stimulation and lateral connections between reservoir neurons can be readout by the sink layer neurons. This activity is used for adaptation of synapses between reservoir and sink layer neurons. A new measure called the discriminability index (DI) is introduced to compute if the network can discriminate between old patterns already presented in an initial training session. The DI is also used to compute if the network adapts to new patterns without losing its ability to discriminate among old patterns. The final outcome is that the network is able to correctly discriminate between all patterns—both old and new. This result holds as long as inhibitory synapses employ STDP to continuously enable current balance in the network. The results suggest a possible direction for future investigation into how spiking neural networks could address the stability-plasticity question despite having continuous synaptic plasticity. PMID:25566045

DOE Office of Scientific and Technical Information (OSTI.GOV)

Winn, Joshua N.; Albrecht, Simon; Johnson, John Asher

We show that the exoplanet HAT-P-7b has an extremely tilted orbit, with a true angle of at least 86 deg. with respect to its parent star's equatorial plane, and a strong possibility of retrograde motion. We also report evidence for an additional planet or companion star. The evidence for the unparalleled orbit and the third body is based on precise observations of the star's apparent radial velocity (RV). The anomalous RV due to rotation (the Rossiter-McLaughlin effect) was found to be a blueshift during the first half of the transit and a redshift during the second half, an inversion ofmore » the usual pattern, implying that the angle between the sky-projected orbital and stellar angular momentum vectors is 182.{sup 0}5 +- 9.{sup 0}4. The third body is implicated by excess RV variation of the host star over 2 yr. Some possible explanations for the tilted orbit of HAT-P-7b are a close encounter with another planet, the Kozai effect, and resonant capture by an inward-migrating outer planet.« less

(abstract) A Geomagnetic Contribution to Climate Change in this Century

NASA Technical Reports Server (NTRS)

Feynman, J.; Ruzmaikin, A.; Lawrence, J.

1996-01-01

There is a myth that all solar effects can be parameterized by the sun spot number. This is not true. For example, the level of geomagnetic activity during this century was not proportional to the sunspot number. Instead there is a large systematic increase in geomagnetic activity, not reflected in the sunspot number. This increase occurred gradually over at least 60 years. The 11 year solar cycle variation was superimposed on this systematic increase. Here we show that this systematic increase in activity is well correlated to the simultaneous increase in terrestrial temperature that occurred during the first half of this century. We discuss these findings in terms of mechanisms by which geomagnetics can be coupled to climate. These mechanisms include possible changes in weather patterns and cloud cover due to increased cosmic ray fluxes, or to increased fluxes of high energy electrons. We suggest that this systematic increase in geomagnetic activity contributed (along with anthropogenic effects and possible changes in solar irradiance) to the changes in climate recorded during this period.

Some Possible Cases of Escape Mimicry in Neotropical Butterflies.

PubMed

Pinheiro, C E G; Freitas, A V L

2014-10-01

The possibility that escape or evasive mimicry evolved in butterflies and other prey insects in a similar fashion to classical Batesian and Müllerian mimicry has long been advanced in the literature. However, there is a general disagreement among lepidopterists and evolutionary biologists on whether or not escape mimicry exists, as well as in which mimicry rings this form of mimicry has evolved. Here, we review some purported cases of escape mimicry in Neotropical butterflies and suggest new mimicry rings involving several species of Archaeoprepona, Prepona, and Doxocopa (the "bright blue bands" ring) and species of Colobura and Hypna (the "creamy bands" ring) where the palatability of butterflies, their ability to escape predator attacks, geographic distribution, relative abundance, and co-occurrence in the same habitats strongly suggest that escape mimicry is involved. In addition, we also indicate other butterfly taxa whose similarities of coloration patterns could be due to escape mimicry and would constitute important case studies for future investigation.

Derivative Sign Patterns in Two Dimensions

ERIC Educational Resources Information Center

Schilling, Kenneth

2013-01-01

Given a function defined on a subset of the plane whose partial derivatives never change sign, the signs of the partial derivatives form a two-dimensional pattern. We explore what patterns are possible for various planar domains.

Patterns of intracellular calcium oscillations in horse oocytes fertilized by intracytoplasmic sperm injection: possible explanations for the low success of this assisted reproduction technique in the horse.

PubMed

Bedford, Sylvia J; Kurokawa, Manabu; Hinrichs, Katrin; Fissore, Rafael A

2004-04-01

In all species studied, fertilization induces intracellular Ca2+ ([Ca2+]i) oscillations required for oocyte activation and embryonic development. This species-specific pattern has not been studied in the equine, partly due to the difficulties linked to in vitro fertilization in this species. Therefore, the objective of this study was to use intracytoplasmic sperm injection (ICSI) to investigate fertilization-induced [Ca2+]i signaling and, possibly, ascertain problems linked to the success of this technology in the horse. In vivo- and in vitro-matured mare oocytes were injected with a single motile stallion sperm. Few oocytes displayed [Ca2+]i responses regardless of oocyte source and we hypothesized that this may result from insufficient release of the sperm-borne active molecule (sperm factor) into the oocyte. However, permeabilization of sperm membranes with Triton-X or by sonication did not alleviate the deficient [Ca2+]i responses in mare oocytes. Thus, we hypothesized that a step downstream of release, possibly required for sperm factor function, is not appropriately accomplished in horse oocytes. To test this, ICSI-fertilized horse oocytes were fused to unfertilized mouse oocytes, which are known to respond with [Ca2+]i oscillations to injection of stallion sperm, and [Ca2+]i monitoring was performed. Such pairs consistently displayed [Ca2+]i responses demonstrating that the sperm factor is appropriately released into the ooplasm of horse oocytes, but that these are unable to activate and/or provide the appropriate substrate that is required for the sperm factor delivered by ICSI to initiate oscillations. These findings may have implications to improve the success of ICSI in the equine and other livestock species.

Discriminative analysis with a limited number of MEG trials in depression.

PubMed

Lu, Qing; Jiang, Haiteng; Bi, Kun; Liu, Chu; Yao, Zhijian

2014-01-01

In studies when exploring distinct patterns of functional abnormalities inherent in depression, experiments are generally repeated over many trials, and then the data are averaged across those trials in order to improve the signal to noise ratio. Repeated stimuli will lead to unpredictable impairment on signals, due to material familiarity or subjects׳ fatigue. In this consideration, signal processing tools powerful on small numbers of trials are expected to alleviate the work load on subjects, especially for mental disease studies. Forty-four subjects, half-depressed patients and half-healthy subjects, were recruited for MEG scanning in response to sad facial stimuli. Multichannel matching pursuit (MMP) was implemented to manage the limited number of trials. The post-MMP MEG signals were utilized to calculate the power topography over the whole brain, as inputs for a Support Vector Machine (SVM) classifier. Standard ICA and conventional ensemble averaging plus Butterworth filtering were employed as well as benchmark studies for performance comparison. A limited number of trials were required via MMP to discriminate the depressive. Post-MMP discriminative analysis revealed a deficit theta pattern and an excessive alpha/beta pattern. The small sample size may impair the stability of the reported findings. The transient tiny variance of the signal was excluded from exploration. The deficit theta pattern together with the excessive alpha/beta pattern in depression may indicate the dysfunction of the limbic-cortical circuit in a 'top-down' process. The post-MMP discrimination helps alleviate the scanning burden, facilitating the possibility for neuroimaging supporting the affective disorder clinical diagnosis. Copyright © 2014 Elsevier B.V. All rights reserved.

Patterns of multiple health risk-behaviours in university students and their association with mental health: application of latent class analysis.

PubMed

Kwan, M Y; Arbour-Nicitopoulos, K P; Duku, E; Faulkner, G

2016-08-01

University and college campuses may be the last setting where it is possible to comprehensively address the health of a large proportion of the young adult population. It is important that health promoters understand the collective challenges students are facing, and to better understand the broader lifestyle behavioural patterning evident during this life stage. The purpose of this study was to examine the clustering of modifiable health-risk behaviours and to explore the relationship between these identified clusters and mental health outcomes among a large Canadian university sample. Undergraduate students (n = 837; mean age = 21 years) from the University of Toronto completed the National College Health Assessment survey. The survey consists of approximately 300 items, including assessments of student health status, mental health and health-risk behaviours. Latent class analysis was used to identify patterning based on eight salient health-risk behaviours (marijuana use, other illicit drug use, risky sex, smoking, binge drinking, poor diet, physical inactivity, and insufficient sleep). A three-class model based on student behavioural patterns emerged: "typical," "high-risk" and "moderately healthy." Results also found high-risk students reporting significantly higher levels of stress than typical students (χ2(1671) = 7.26, p < .01). Students with the highest likelihood of engaging in multiple health-risk behaviours reported poorer mental health, particularly as it relates to stress. Although these findings should be interpreted with caution due to the 28% response rate, they do suggest that interventions targeting specific student groups with similar patterning of multiple health-risk behaviours may be needed.

Flipping Triangles!

ERIC Educational Resources Information Center

Zucker, Marc

2009-01-01

We introduce a simple game made up of a board of coins on a triangular lattice. We then study the possibility of turning the board from one pattern of heads and tails to some other pattern. Given that a solution exists we find a precise answer to the number of solutions possible. We then generalize this to more complex boards with coins of many…

Is the mu-oxo-mu-peroxodiiron intermediate of a ribonucleotide reductase biomimetic a possible oxidant of epoxidation reactions?

PubMed

de Visser, Sam P

2008-01-01

Density functional calculations on a mu-oxo-mu-peroxodiiron complex (1) with a tetrapodal ligand BPP (BPP=N,N-bis(2-pyridylmethyl)-3-aminopropionate) are presented that is a biomimetic of the active site region of ribonucleotide reductase (RNR). We have studied all low-lying electronic states and show that it has close-lying broken-shell singlet and undecaplet (S=0, 5) ground states with essentially two sextet spin iron atoms. In strongly distorted electronic systems in which the two iron atoms have different spin states, the peroxo group moves considerably out of the plane of the mu-oxodiiron group due to orbital rearrangements. The calculated absorption spectra of (1,11)1 are in good agreement with experimental studies on biomimetics and RNR enzyme systems. Moreover, vibrational shifts in the spectrum due to (18)O(2) substitution of the oxygen atoms in the peroxo group follow similar trends as experimental observations. To identify whether the mu-oxo-mu-1,2-peroxodiiron or the mu-oxo-mu-1,1-peroxodiiron complexes are able to epoxidize substrates, we studied the reactivity patterns versus propene. Generally, the reactions are stepwise via radical intermediates and proceed by two-state reactivity patterns on competing singlet and undecaplet spin state surfaces. However, both the mu-oxo-mu-1,2-peroxodiiron and mu-oxo-mu-1,1-peroxodiiron complex are sluggish oxidants with high epoxidation barriers. The epoxidation barriers for the mu-oxo-mu-1,1-peroxodiiron complex are significantly lower than the ones for the mu-oxo-mu-1,2-peroxodiiron complex but still are too high to be considered for catalytic properties. Thus, theory has ruled out two possible peroxodiiron catalysts as oxidants in RNR enzymes and biomimetics and the quest to find the actual oxidant in the enzyme mechanism continues.

Spatial analysis of Carbon-14 dynamics in a wetland ecosystem (Duke Swamp, Chalk River Laboratories, Canada).

PubMed

Yankovich, T L; King-Sharp, K J; Carr, J; Robertson, E; Killey, R W D; Beresford, N A; Wood, M D

2014-11-01

A detailed survey was conducted to quantify the spatial distribution of (14)C in Sphagnum moss and underlying soil collected in Duke Swamp. This wetland environment receives (14)C via groundwater pathways from a historic radioactive Waste Management Area (WMA) on Atomic Energy Canada Limited (AECL)'s Chalk River Laboratories (CRL) site. Trends in (14)C specific activities were evaluated with distance from the sampling location with the maximum (14)C specific activity (DSS-35), which was situated adjacent to the WMA and close to an area of groundwater discharge. Based on a spatial evaluation of the data, an east-to-west (14)C gradient was found, due to the influence of the WMA on (14)C specific activities in the swamp. In addition, it was possible to identify two groups of sites, each showing significant exponential declines with distance from the groundwater source area. One of the groups showed relatively more elevated (14)C specific activities at a given distance from source, likely due to their proximity to the WMA, the location of the sub-surface plume originating from the WMA, the presence of marsh and swamp habitat types, which facilitated (14)C transport to the atmosphere, and possibly, (14)C air dispersion patterns along the eastern edge of the swamp. The other group, which had lower (14)C specific activities at a given distance from the groundwater source area, included locations that were more distant from the WMA and the sub-surface plume, and contained fen habitat, which is known to act as barrier to groundwater flow. The findings suggest that proximity to source, groundwater flow patterns and habitat physical characteristics can play an important role in the dynamics of (14)C being carried by discharging groundwater into terrestrial and wetland environments. Copyright © 2014 Elsevier Ltd. All rights reserved.

A method for determining the radius of an open cluster from stellar proper motions

NASA Astrophysics Data System (ADS)

Sánchez, Néstor; Alfaro, Emilio J.; López-Martínez, Fátima

2018-04-01

We propose a method for calculating the radius of an open cluster in an objective way from an astrometric catalogue containing, at least, positions and proper motions. It uses the minimum spanning tree in the proper motion space to discriminate cluster stars from field stars and it quantifies the strength of the cluster-field separation by means of a statistical parameter defined for the first time in this paper. This is done for a range of different sampling radii from where the cluster radius is obtained as the size at which the best cluster-field separation is achieved. The novelty of this strategy is that the cluster radius is obtained independently of how its stars are spatially distributed. We test the reliability and robustness of the method with both simulated and real data from a well-studied open cluster (NGC 188), and apply it to UCAC4 data for five other open clusters with different catalogued radius values. NGC 188, NGC 1647, NGC 6603, and Ruprecht 155 yielded unambiguous radius values of 15.2 ± 1.8, 29.4 ± 3.4, 4.2 ± 1.7, and 7.0 ± 0.3 arcmin, respectively. ASCC 19 and Collinder 471 showed more than one possible solution, but it is not possible to know whether this is due to the involved uncertainties or due to the presence of complex patterns in their proper motion distributions, something that could be inherent to the physical object or due to the way in which the catalogue was sampled.

End-Cretaceous extinction in Antarctica linked to both Deccan volcanism and meteorite impact via climate change

PubMed Central

Petersen, Sierra V.; Dutton, Andrea; Lohmann, Kyger C.

2016-01-01

The cause of the end-Cretaceous (KPg) mass extinction is still debated due to difficulty separating the influences of two closely timed potential causal events: eruption of the Deccan Traps volcanic province and impact of the Chicxulub meteorite. Here we combine published extinction patterns with a new clumped isotope temperature record from a hiatus-free, expanded KPg boundary section from Seymour Island, Antarctica. We document a 7.8±3.3 °C warming synchronous with the onset of Deccan Traps volcanism and a second, smaller warming at the time of meteorite impact. Local warming may have been amplified due to simultaneous disappearance of continental or sea ice. Intra-shell variability indicates a possible reduction in seasonality after Deccan eruptions began, continuing through the meteorite event. Species extinction at Seymour Island occurred in two pulses that coincide with the two observed warming events, directly linking the end-Cretaceous extinction at this site to both volcanic and meteorite events via climate change. PMID:27377632

Language Lateralization Shifts with Learning by Adults

PubMed Central

Plante, Elena; Almryde, Kyle; Patterson, Dianne K.; Vance, Christopher J.; Asbjørnsen, Arve E.

2014-01-01

For the majority of the population, language is a left hemisphere lateralized function. During childhood, a pattern of increasing left lateralization for language has been described in brain imaging studies, suggesting this trait develops. This development could reflect change due to brain maturation or change due to skill acquisition, given that children acquire and refine language skills as they mature. We test the possibility that skill acquisition, independent of age-associated maturation can result in shifts in language lateralization in classic language cortex. We imaged adults exposed to unfamiliar language during three successive fMRI scans. Participants were then asked to identify specific words embedded in Norwegian sentences. Exposure to these sentences, relative to complex tones, resulted in consistent activation in the left and right superior temporal gyrus. Activation in this region became increasingly left lateralized with repeated exposure to the unfamiliar language. These results demonstrate that shifts in lateralization can be produced in the short-term within a learning context, independent of maturation. PMID:25285756

End-Cretaceous extinction in Antarctica linked to both Deccan volcanism and meteorite impact via climate change.

PubMed

Petersen, Sierra V; Dutton, Andrea; Lohmann, Kyger C

2016-07-05

The cause of the end-Cretaceous (KPg) mass extinction is still debated due to difficulty separating the influences of two closely timed potential causal events: eruption of the Deccan Traps volcanic province and impact of the Chicxulub meteorite. Here we combine published extinction patterns with a new clumped isotope temperature record from a hiatus-free, expanded KPg boundary section from Seymour Island, Antarctica. We document a 7.8±3.3 °C warming synchronous with the onset of Deccan Traps volcanism and a second, smaller warming at the time of meteorite impact. Local warming may have been amplified due to simultaneous disappearance of continental or sea ice. Intra-shell variability indicates a possible reduction in seasonality after Deccan eruptions began, continuing through the meteorite event. Species extinction at Seymour Island occurred in two pulses that coincide with the two observed warming events, directly linking the end-Cretaceous extinction at this site to both volcanic and meteorite events via climate change.

End-Cretaceous extinction in Antarctica linked to both Deccan volcanism and meteorite impact via climate change

NASA Astrophysics Data System (ADS)

Petersen, Sierra V.; Dutton, Andrea; Lohmann, Kyger C.

2016-07-01

The cause of the end-Cretaceous (KPg) mass extinction is still debated due to difficulty separating the influences of two closely timed potential causal events: eruption of the Deccan Traps volcanic province and impact of the Chicxulub meteorite. Here we combine published extinction patterns with a new clumped isotope temperature record from a hiatus-free, expanded KPg boundary section from Seymour Island, Antarctica. We document a 7.8+/-3.3 °C warming synchronous with the onset of Deccan Traps volcanism and a second, smaller warming at the time of meteorite impact. Local warming may have been amplified due to simultaneous disappearance of continental or sea ice. Intra-shell variability indicates a possible reduction in seasonality after Deccan eruptions began, continuing through the meteorite event. Species extinction at Seymour Island occurred in two pulses that coincide with the two observed warming events, directly linking the end-Cretaceous extinction at this site to both volcanic and meteorite events via climate change.

A Multivariate Analysis of Metal Concentrations in Two Fish Species of the Nyl River System, Limpopo Province, South Africa.

PubMed

Musa, R; Gerber, R; Greenfield, R

2017-06-01

Increased toxicity due to high metal concentrations may hinder the ecological integrity of aquatic ecosystems in sustaining life. The non-biodegradable nature of metals may result in bioaccumulation in aquatic organisms. Due to ecological and social aspects it is imperative for monitoring schemes to identify possible impacts to the systems integrity. This paper discusses accumulation patterns of seven metals (Al, Cr, Cu, Fe, Mn, Sr and Zn) in tissues of two fish species, namely Clarias gariepinus and Oreochromis mossambicus at two selected sites, the first located upstream of Modimolle (NRS1), and the second located downstream of the town (NRS2). Gills, liver, muscle and skin tissues were analysed for metal concentrations using standard microwave digestion and inductively coupled plasma mass spectrometry techniques. Statistical results indicated higher concentrations of metals at NRS2 in comparison to NRS1, indicating that Modimolle plays a potential role in introducing metals into the aquatic system.

On the Influence of Nb/Ti Ratio on Environmentally-Assisted Crack Growth in High-Strength Nickel-Based Superalloys

NASA Astrophysics Data System (ADS)

Németh, A. A. N.; Crudden, D. J.; Collins, D. M.; Kuksenko, V.; Liebscher, C. H.; Armstrong, D. E. J.; Wilkinson, A. J.; Reed, R. C.

2018-05-01

The effect of Nb/Ti ratio on environmentally-assisted crack growth of three prototype Ni-based superalloys is studied. For these alloys, the yield strength is unaltered with increasing Nb/Ti ratio due to an increase in grain size. This situation has allowed the rationalization of the factors influencing damage tolerance at 700 °C. Primary intergranular cracks have been investigated using energy-dispersive X-ray spectroscopy in a scanning transmission electron microscope and the analysis of electron back-scatter diffraction patterns. Any possible detrimental effect of Nb on the observed crack tip damage due to Nb-rich oxide formation is not observed. Instead, evidence is presented to indicate that the tertiary γ'-precipitates are dissolving ahead of the crack consistent with the formation of oxides such as alumina and rutile. Our results have implications for alloy design efforts; at any given strength level, both more and less damage-tolerant variants of these alloys can be designed.

Wave energy level and geographic setting correlate with Florida beach water quality.

PubMed

Feng, Zhixuan; Reniers, Ad; Haus, Brian K; Solo-Gabriele, Helena M; Kelly, Elizabeth A

2016-03-15

Many recreational beaches suffer from elevated levels of microorganisms, resulting in beach advisories and closures due to lack of compliance with Environmental Protection Agency guidelines. We conducted the first statewide beach water quality assessment by analyzing decadal records of fecal indicator bacteria (enterococci and fecal coliform) levels at 262 Florida beaches. The objectives were to depict synoptic patterns of beach water quality exceedance along the entire Florida shoreline and to evaluate their relationships with wave condition and geographic location. Percent exceedances based on enterococci and fecal coliform were negatively correlated with both long-term mean wave energy and beach slope. Also, Gulf of Mexico beaches exceeded the thresholds significantly more than Atlantic Ocean ones, perhaps partially due to the lower wave energy. A possible linkage between wave energy level and water quality is beach sand, a pervasive nonpoint source that tends to harbor more bacteria in the low-wave-energy environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

Variation in organic matter and water color in Lake Mälaren during the past 70 years.

PubMed

Johansson, L; Temnerud, J; Abrahamsson, J; Berggren Kleja, D

2010-03-01

Interest in long time series of organic matter data has recently increased due to concerns about the effects of global climate change on aquatic ecosystems. This study presents and evaluates unique time series of chemical oxygen demand (COD) and water color from Lake Malaren, Sweden, stretching almost seven decades (1935-2004). A negative linear trend was found in COD, but not in water color. The decrease was mainly due to installation of sewage works around 1970. Time series of COD and water color had cyclic pattern. It was strongest for COD, with 23 years periodicity. Similar periodicity observed in air temperature and precipitation in Sweden has been attributed to the North Atlantic Oscillation index and solar system orbit, suggesting that COD in Lake Mälaren is partly derived from algae. Discharge influenced water color more than COD, possibly because water color consists of colored substances brought into the lake from surrounding soils.

Spatial assessment of air quality patterns in Malaysia using multivariate analysis

NASA Astrophysics Data System (ADS)

Dominick, Doreena; Juahir, Hafizan; Latif, Mohd Talib; Zain, Sharifuddin M.; Aris, Ahmad Zaharin

2012-12-01

This study aims to investigate possible sources of air pollutants and the spatial patterns within the eight selected Malaysian air monitoring stations based on a two-year database (2008-2009). The multivariate analysis was applied on the dataset. It incorporated Hierarchical Agglomerative Cluster Analysis (HACA) to access the spatial patterns, Principal Component Analysis (PCA) to determine the major sources of the air pollution and Multiple Linear Regression (MLR) to assess the percentage contribution of each air pollutant. The HACA results grouped the eight monitoring stations into three different clusters, based on the characteristics of the air pollutants and meteorological parameters. The PCA analysis showed that the major sources of air pollution were emissions from motor vehicles, aircraft, industries and areas of high population density. The MLR analysis demonstrated that the main pollutant contributing to variability in the Air Pollutant Index (API) at all stations was particulate matter with a diameter of less than 10 μm (PM10). Further MLR analysis showed that the main air pollutant influencing the high concentration of PM10 was carbon monoxide (CO). This was due to combustion processes, particularly originating from motor vehicles. Meteorological factors such as ambient temperature, wind speed and humidity were also noted to influence the concentration of PM10.

Oceanographic Currents and Local Ecological Knowledge Indicate, and Genetics Does Not Refute, a Contemporary Pattern of Larval Dispersal for The Ornate Spiny Lobster, Panulirus ornatus in the South-East Asian Archipelago

PubMed Central

Dao, Hoc Tan; Smith-Keune, Carolyn; Wolanski, Eric; Jones, Clive M.; Jerry, Dean R.

2015-01-01

Here we utilize a combination of genetic data, oceanographic data, and local ecological knowledge to assess connectivity patterns of the ornate spiny lobster Panulirus ornatus (Fabricius, 1798) in the South-East Asian archipelago from Vietnam to Australia. Partial mitochondrial DNA control region and 10 polymorphic microsatellites did not detect genetic structure of 216 wild P. ornatus samples from Australia, Indonesia and Vietnam. Analyses show no evidence for genetic differentiation among populations (mtDNA control region sequences ΦST = -0.008; microsatellite loci FST = 0.003). A lack of evidence for regional or localized mtDNA haplotype clusters, or geographic clusters of microsatellite genotypes, reveals a pattern of high gene flow in P. ornatus throughout the South-East Asian Archipelago. This lack of genetic structure may be due to the oceanography-driven connectivity of the pelagic lobster larvae between spawning grounds in Papua New Guinea, the Philippines and, possibly, Indonesia. The connectivity cycle necessitates three generations. The lack of genetic structure of P. ornatus population in the South-East Asian archipelago has important implications for the sustainable management of this lobster in that the species within the region needs to be managed as one genetic stock. PMID:25951344

New paradigm for task switching strategies while performing multiple tasks: entropy and symbolic dynamics analysis of voluntary patterns.

PubMed

Guastello, Stephen J; Gorin, Hillary; Huschen, Samuel; Peters, Natalie E; Fabisch, Megan; Poston, Kirsten

2012-10-01

It has become well established in laboratory experiments that switching tasks, perhaps due to interruptions at work, incur costs in response time to complete the next task. Conditions are also known that exaggerate or lessen the switching costs. Although switching costs can contribute to fatigue, task switching can also be an adaptive response to fatigue. The present study introduces a new research paradigm for studying the emergence of voluntary task switching regimes, self-organizing processes therein, and the possibly conflicting roles of switching costs and minimum entropy. Fifty-four undergraduates performed 7 different computer-based cognitive tasks producing sets of 49 responses under instructional conditions requiring task quotas or no quotas. The sequences of task choices were analyzed using orbital decomposition to extract pattern types and lengths, which were then classified and compared with regard to Shannon entropy, topological entropy, number of task switches involved, and overall performance. Results indicated that similar but different patterns were generated under the two instructional conditions, and better performance was associated with lower topological entropy. Both entropy metrics were associated with the amount of voluntary task switching. Future research should explore conditions affecting the trade-off between switching costs and entropy, levels of automaticity between task elements, and the role of voluntary switching regimes on fatigue.

Biogeography and divergent patterns of body size disparification in North American minnows.

PubMed

Martin, Samuel D; Bonett, Ronald M

2015-12-01

Body size is one of the most important traits influencing an organism's ecology and a major axis of evolutionary change. We examined body size disparification in the highly speciose North American minnows (Cyprinidae), which exhibit diverse body sizes and ecologies, including the giant piscivorous pikeminnows. We estimated a novel phylogeny for 285 species based on a supermatrix alignment of seven mitochondrial and ten nuclear genes, and used this to reconstruct ancestral body sizes (log-total length) and ancestral area. Additionally, given that fishes inhabiting Pacific drainages have historically been subjected to frequent local extinctions due to periodic flooding, droughts, and low drainage connectivity, we also compared body size disparification between the highly speciose Atlantic drainages and comparatively depauperate Pacific drainages. We found that dispersal between Atlantic and Pacific drainages has been infrequent and generally occurred in minnows with southerly distributions, where drainage systems are younger and less stable. The long isolation between Atlantic and Pacific drainages has allowed for divergent patterns of morphological disparification; we found higher rates of body size disparification in minnows from the environmentally harsher Pacific drainages. We propose several possible explanations for the observed patterns of size disparification in the context of habitat stability, niche space, and species diversification. Copyright © 2015 Elsevier Inc. All rights reserved.

Improvement of plastic optical fiber microphone based on moisture pattern sensing in devoiced breath

NASA Astrophysics Data System (ADS)

Taki, Tomohito; Honma, Satoshi; Morisawa, Masayuki; Muto, Shinzo

2008-03-01

Conversation is the most practical and common form in communication. However, people with a verbal handicap feel a difficulty to produce words due to variations in vocal chords. This research leads to develop a new devoiced microphone system based on distinguishes between the moisture patterns for each devoiced breaths, using a plastic optical fiber (POF) moisture sensor. In the experiment, five POF-type moisture sensors with fast response were fabricated by coating swell polymer with a slightly larger refractive index than that of fiber core and were set in front of mouth. When these sensors are exposed into humid air produced by devoiced breath, refractive index in cladding layer decreases by swelling and then the POF sensor heads change to guided type. Based on the above operation principle, the output light intensities from the five sensors set in front of mouth change each other. Using above mentioned output light intensity patterns, discernment of devoiced vowels in Japanese (a,i,u,e,o) was tried by means of DynamicProgramming-Matching (DP-matching) method. As the result, distinction rate over 90% was obtained to Japanese devoiced vowels. Therefore, using this system and a voice synthesizer, development of new microphone for the person with a functional disorder in the vocal chords seems to be possible.

Stress Effects in Vowel Perception as a Function of Language-Specific Vocabulary Patterns.

PubMed

Warner, Natasha; Cutler, Anne

2017-01-01

Evidence from spoken word recognition suggests that for English listeners, distinguishing full versus reduced vowels is important, but discerning stress differences involving the same full vowel (as in mu- from music or museum) is not. In Dutch, in contrast, the latter distinction is important. This difference arises from the relative frequency of unstressed full vowels in the two vocabularies. The goal of this paper is to determine how this difference in the lexicon influences the perception of stressed versus unstressed vowels. All possible sequences of two segments (diphones) in Dutch and in English were presented to native listeners in gated fragments. We recorded identification performance over time throughout the speech signal. The data were here analysed specifically for patterns in perception of stressed versus unstressed vowels. The data reveal significantly larger stress effects (whereby unstressed vowels are harder to identify than stressed vowels) in English than in Dutch. Both language-specific and shared patterns appear regarding which vowels show stress effects. We explain the larger stress effect in English as reflecting the processing demands caused by the difference in use of unstressed vowels in the lexicon. The larger stress effect in English is due to relative inexperience with processing unstressed full vowels. © 2016 S. Karger AG, Basel.

Low Cost Beam-Steering Approach for a Series-Fed Array

NASA Technical Reports Server (NTRS)

Host, Nicholas K.; Chen, Chi-Chih; Volakis, John L.; Miranda, Felix A.

2013-01-01

Phased array antennas showcase many advantages over mechanically steered systems. However, they are also more complex and costly. This paper presents a concept which overcomes these detrimental attributes by eliminating all of the phased array backend (including phase shifters). Instead, a propagation constant reconfigurable transmission line in a series fed array arrangement is used to allow phase shifting with one small (less than or equal to 100mil) linear mechanical motion. A novel slotted coplanar stripline design improves on previous transmission lines by demonstrating a greater control of propagation constant, thus allowing practical prototypes to be built. Also, beam steering pattern control is explored. We show that with correct choice of line impedance, pattern control is possible for all scan angles. A 20 element array scanning from -25 deg less than or equal to theta less than or equal to 21 deg. with mostly uniform gain at 13GHz is presented. Measured patterns show a reduced scan range of 12 deg. less than or equal to theta less than or equal to 25 deg. due to a correctable manufacturing error as verified by simulation. Beam squint is measured to be plus or minus 2.5 deg for a 600MHz bandwidth and cross-pol is measured to be at least -15dB.

Antimicrobial Resistance in Enterococcus spp. Isolated from Environmental Samples in an Area of Intensive Poultry Production

PubMed Central

Furtula, Vesna; Jackson, Charlene R.; Farrell, Erin Gwenn; Barrett, John B.; Hiott, Lari M.; Chambers, Patricia A.

2013-01-01

Enterococcus spp. from two poultry farms and proximate surface and ground water sites in an area of intensive poultry production were tested for resistance to 16 clinical antibiotics. Resistance patterns were compared to assess trends and possible correlations for specific antimicrobials and levels of resistance. Enterococci were detected at all 12 surface water sites and three of 28 ground water sites. Resistance to lincomycin, tetracycline, penicillin and ciprofloxacin in poultry litter isolates was high (80.3%, 65.3%, 61.1% and 49.6%, respectively). Resistance in the surface water to the same antibiotics was 87.1%, 24.1%, 7.6% and 12.9%, respectively. Overall, 86% of litter isolates, 58% of surface water isolates and 100% of ground water isolates were resistant to more than one antibiotic. Fifty-four different resistance patterns were recognised in isolates obtained from litter and environmental samples and several E. faecium and E. faecalis isolates from litter and environment samples shared the same resistance pattern. Multiple antibiotic resistant (MAR) indices calculated to assess health risks due to the presence of resistant enterococci suggested an increased presence of antibiotics in surface water, likely from poultry sources as no other wastewater contributions in the area were documented. PMID:23481592

Multiscale mobility networks and the spatial spreading of infectious diseases.

PubMed

Balcan, Duygu; Colizza, Vittoria; Gonçalves, Bruno; Hu, Hao; Ramasco, José J; Vespignani, Alessandro

2009-12-22

Among the realistic ingredients to be considered in the computational modeling of infectious diseases, human mobility represents a crucial challenge both on the theoretical side and in view of the limited availability of empirical data. To study the interplay between short-scale commuting flows and long-range airline traffic in shaping the spatiotemporal pattern of a global epidemic we (i) analyze mobility data from 29 countries around the world and find a gravity model able to provide a global description of commuting patterns up to 300 kms and (ii) integrate in a worldwide-structured metapopulation epidemic model a timescale-separation technique for evaluating the force of infection due to multiscale mobility processes in the disease dynamics. Commuting flows are found, on average, to be one order of magnitude larger than airline flows. However, their introduction into the worldwide model shows that the large-scale pattern of the simulated epidemic exhibits only small variations with respect to the baseline case where only airline traffic is considered. The presence of short-range mobility increases, however, the synchronization of subpopulations in close proximity and affects the epidemic behavior at the periphery of the airline transportation infrastructure. The present approach outlines the possibility for the definition of layered computational approaches where different modeling assumptions and granularities can be used consistently in a unifying multiscale framework.

Change of ocean circulation in the East Asian Marginal Seas under different climate conditions

NASA Astrophysics Data System (ADS)

Min, Hong Sik; Kim, Cheol-Ho; Kim, Young Ho

2010-05-01

Global climate models do not properly resolve an ocean environment in the East Asian Marginal Seas (EAMS), which is mainly due to a poor representation of the topography in continental shelf region and a coarse spatial resolution. To examine a possible change of ocean environment under global warming in the EAMS, therefore we used North Pacific Regional Ocean Model. The regional model was forced by atmospheric conditions extracted from the simulation results of the global climate models for the 21st century projected by the IPCC SRES A1B scenario as well as the 20th century. The North Pacific Regional Ocean model simulated a detailed pattern of temperature change in the EAMS showing locally different rising or falling trend under the future climate condition, while the global climate models simulated a simple pattern like an overall increase. Changes of circulation pattern in the EAMS such as an intrusion of warm water into the Yellow Sea as well as the Kuroshio were also well resolved. Annual variations in volume transports through the Taiwan Strait and the Korea Strait under the future condition were simulated to be different from those under present condition. Relative ratio of volume transport through the Soya Strait to the Tsugaru Strait also responded to the climate condition.

Oceanographic Currents and Local Ecological Knowledge Indicate, and Genetics Does Not Refute, a Contemporary Pattern of Larval Dispersal for The Ornate Spiny Lobster, Panulirus ornatus in the South-East Asian Archipelago.

PubMed

Dao, Hoc Tan; Smith-Keune, Carolyn; Wolanski, Eric; Jones, Clive M; Jerry, Dean R

2015-01-01

Here we utilize a combination of genetic data, oceanographic data, and local ecological knowledge to assess connectivity patterns of the ornate spiny lobster Panulirus ornatus (Fabricius, 1798) in the South-East Asian archipelago from Vietnam to Australia. Partial mitochondrial DNA control region and 10 polymorphic microsatellites did not detect genetic structure of 216 wild P. ornatus samples from Australia, Indonesia and Vietnam. Analyses show no evidence for genetic differentiation among populations (mtDNA control region sequences ΦST = -0.008; microsatellite loci FST = 0.003). A lack of evidence for regional or localized mtDNA haplotype clusters, or geographic clusters of microsatellite genotypes, reveals a pattern of high gene flow in P. ornatus throughout the South-East Asian Archipelago. This lack of genetic structure may be due to the oceanography-driven connectivity of the pelagic lobster larvae between spawning grounds in Papua New Guinea, the Philippines and, possibly, Indonesia. The connectivity cycle necessitates three generations. The lack of genetic structure of P. ornatus population in the South-East Asian archipelago has important implications for the sustainable management of this lobster in that the species within the region needs to be managed as one genetic stock.

Spectral identification of sperm whales from Littoral Acoustic Demonstration Center passive acoustic recordings

NASA Astrophysics Data System (ADS)

Sidorovskaia, Natalia A.; Richard, Blake; Ioup, George E.; Ioup, Juliette W.

2005-09-01

The Littoral Acoustic Demonstration Center (LADC) made a series of passive broadband acoustic recordings in the Gulf of Mexico and Ligurian Sea to study noise and marine mammal phonations. The collected data contain a large amount of various types of sperm whale phonations, such as isolated clicks and communication codas. It was previously reported that the spectrograms of the extracted clicks and codas contain well-defined null patterns that seem to be unique for individuals. The null pattern is formed due to individual features of the sound production organs of an animal. These observations motivated the present studies of adapting human speech identification techniques for deep-diving marine mammal phonations. A three-state trained hidden Markov model (HMM) was used with the phonation spectra of sperm whales. The HHM-algorithm gave 75% accuracy in identifying individuals when it had been initially tested for the acoustic data set correlated with visual observations of sperm whales. A comparison of the identification accuracy based on null-pattern similarity analysis and the HMM-algorithm is presented. The results can establish the foundation for developing an acoustic identification database for sperm whales and possibly other deep-diving marine mammals that would be difficult to observe visually. [Research supported by ONR.

SAQP pitch walk metrology using single target metrology

NASA Astrophysics Data System (ADS)

Fang, Fang; Herrera, Pedro; Kagalwala, Taher; Camp, Janay; Vaid, Alok; Pandev, Stilian; Zach, Franz

2017-03-01

Self-aligned quadruple patterning (SAQP) processes have found widespread acceptance in advanced technology nodes to drive device scaling beyond the resolution limitations of immersion scanners. Of the four spaces generated in this process from one lithography pattern two tend to be equivalent as they are derived from the first spacer deposition. The three independent spaces are commonly labelled as α, β and γ. α, β and γ are controlled by multiple process steps including the initial lithographic patterning process, the two mandrel and spacer etches as well as the two spacer depositions. Scatterometry has been the preferred metrology approach, however is restricted to repetitive arrays. In these arrays independent measurements, in particular of alpha and gamma, are not possible due to degeneracy of the standard array targets. . In this work we present a single target approach which lifts the degeneracies commonly encountered while using product relevant layout geometries. We will first describe the metrology approach which includes the previously described SRM (signal response metrology) combined with reference data derived from CD SEM data. The performance of the methodology is shown in figures 1-3. In these figures the optically determined values for alpha, beta and gamma are compared to the CD SEM reference data. The variations are achieved using controlled process experiments varying Mandrel CD and Spacer deposition thicknesses.

A universal approach to fabricate ordered colloidal crystals arrays based on electrostatic self-assembly.

PubMed

Zhang, Xun; Zhang, Junhu; Zhu, Difu; Li, Xiao; Zhang, Xuemin; Wang, Tieqiang; Yang, Bai

2010-12-07

We present a novel and simple method to fabricate two-dimensional (2D) poly(styrene sulfate) (PSS, negatively charged) colloidal crystals on a positively charged substrate. Our strategy contains two separate steps: one is the three-dimensional (3D) assembly of PSS particles in ethanol, and the other is electrostatic adsorption in water. First, 3D assembly in ethanol phase eliminates electrostatic attractions between colloids and the substrate. As a result, high-quality colloidal crystals are easily generated, for electrostatic attractions are unfavorable for the movement of colloidal particles during convective self-assembly. Subsequently, top layers of colloidal spheres are washed away in the water phase, whereas well-packed PSS colloids that are in contact with the substrate are tightly linked due to electrostatic interactions, resulting in the formation of ordered arrays of 2D colloidal spheres. Cycling these processes leads to the layer-by-layer assembly of 3D colloidal crystals with controllable layers. In addition, this strategy can be extended to the fabrication of patterned 2D colloidal crystals on patterned polyelectrolyte surfaces, not only on planar substrates but also on nonplanar substrates. This straightforward method may open up new possibilities for practical use of colloidal crystals of excellent quality, various patterns, and controllable fashions.

Effects of the Laramide Structures on the Regional Distribution of Tight-Gas Sandstone in the Upper Mesaverde Group, Uinta Basin, Utah

NASA Astrophysics Data System (ADS)

Sitaula, R. P.; Aschoff, J.

2013-12-01

Regional-scale sequence stratigraphic correlation, well log analysis, syntectonic unconformity mapping, isopach maps, and depositional environment maps of the upper Mesaverde Group (UMG) in Uinta basin, Utah suggest higher accommodation in northeastern part (Natural Buttes area) and local development of lacustrine facies due to increased subsidence caused by uplift of San Rafael Swell (SRS) in southern and Uinta Uplift in northern parts. Recently discovered lacustrine facies in Natural Buttes area are completely different than the dominant fluvial facies in outcrops along Book Cliffs and could have implications for significant amount of tight-gas sand production from this area. Data used for sequence stratigraphic correlation, isopach maps and depositional environmental maps include > 100 well logs, 20 stratigraphic profiles, 35 sandstone thin sections and 10 outcrop-based gamma ray profiles. Seven 4th order depositional sequences (~0.5 my duration) are identified and correlated within UMG. Correlation was constructed using a combination of fluvial facies and stacking patterns in outcrops, chert-pebble conglomerates and tidally influenced strata. These surfaces were extrapolated into subsurface by matching GR profiles. GR well logs and core log of Natural Buttes area show intervals of coarsening upward patterns suggesting possible lacustrine intervals that might contain high TOC. Locally, younger sequences are completely truncated across SRS whereas older sequences are truncated and thinned toward SRS. The cycles of truncation and thinning represent phases of SRS uplift. Thinning possibly related with the Uinta Uplift is also observed in northwestern part. Paleocurrents are consistent with interpretation of periodic segmentation and deflection of sedimentation. Regional paleocurrents are generally E-NE-directed in Sequences 1-4, and N-directed in Sequences 5-7. From isopach maps and paleocurrent direction it can be interpreted that uplift of SRS changed route of sediment supply from west to southwest. Locally, paleocurrents are highly variable near SRS further suggesting UMG basin-fill was partitioned by uplift of SRS. Sandstone composition analysis also suggests the uplift of SRS causing the variation of source rocks in upper sequences than the lower sequences. In conclusion, we suggest that Uinta basin was episodically partitioned during the deposition of UMG due to uplift of Laramide structures in the basin and accommodation was localized in northeastern part. Understanding of structural controls on accommodation, sedimentation patterns and depositional environments will aid prediction of the best-producing gas reservoirs.

Drift, selection, or migration? Processes affecting genetic differentiation and variation along a latitudinal gradient in an amphibian.

PubMed

Cortázar-Chinarro, Maria; Lattenkamp, Ella Z; Meyer-Lucht, Yvonne; Luquet, Emilien; Laurila, Anssi; Höglund, Jacob

2017-08-14

Past events like fluctuations in population size and post-glacial colonization processes may influence the relative importance of genetic drift, migration and selection when determining the present day patterns of genetic variation. We disentangle how drift, selection and migration shape neutral and adaptive genetic variation in 12 moor frog populations along a 1700 km latitudinal gradient. We studied genetic differentiation and variation at a MHC exon II locus and a set of 18 microsatellites. Using outlier analyses, we identified the MHC II exon 2 (corresponding to the β-2 domain) locus and one microsatellite locus (RCO8640) to be subject to diversifying selection, while five microsatellite loci showed signals of stabilizing selection among populations. STRUCTURE and DAPC analyses on the neutral microsatellites assigned populations to a northern and a southern cluster, reflecting two different post-glacial colonization routes found in previous studies. Genetic variation overall was lower in the northern cluster. The signature of selection on MHC exon II was weaker in the northern cluster, possibly as a consequence of smaller and more fragmented populations. Our results show that historical demographic processes combined with selection and drift have led to a complex pattern of differentiation along the gradient where some loci are more divergent among populations than predicted from drift expectations due to diversifying selection, while other loci are more uniform among populations due to stabilizing selection. Importantly, both overall and MHC genetic variation are lower at northern latitudes. Due to lower evolutionary potential, the low genetic variation in northern populations may increase the risk of extinction when confronted with emerging pathogens and climate change.

Molecular Population Genetics of the Alcohol Dehydrogenase Gene Region of DROSOPHILA MELANOGASTER

PubMed Central

Aquadro, Charles F.; Desse, Susan F.; Bland, Molly M.; Langley, Charles H.; Laurie-Ahlberg, Cathy C.

1986-01-01

Variation in the DNA restriction map of a 13-kb region of chromosome II including the alcohol dehydrogenase structural gene (Adh) was examined in Drosophila melanogaster from natural populations. Detailed analysis of 48 D. melanogaster lines representing four eastern United States populations revealed extensive DNA sequence variation due to base substitutions, insertions and deletions. Cloning of this region from several lines allowed characterization of length variation as due to unique sequence insertions or deletions [nine sizes; 21–200 base pairs (bp)] or transposable element insertions (several sizes, 340 bp to 10.2 kb, representing four different elements). Despite this extensive variation in sequences flanking the Adh gene, only one length polymorphism is clearly associated with altered Adh expression (a copia element approximately 250 bp 5' to the distal transcript start site). Nonetheless, the frequency spectra of transposable elements within and between Drosophila species suggests they are slightly deleterious. Strong nonrandom associations are observed among Adh region sequence variants, ADH allozyme (Fast vs. Slow), ADH enzyme activity and the chromosome inversion ln(2L) t. Phylogenetic analysis of restriction map haplotypes suggest that the major twofold component of ADH activity variation (high vs. low, typical of Fast and Slow allozymes, respectively) is due to sequence variation tightly linked to and possibly distinct from that underlying the allozyme difference. The patterns of nucleotide and haplotype variation for Fast and Slow allozyme lines are consistent with the recent increase in frequency and spread of the Fast haplotype associated with high ADH activity. These data emphasize the important role of evolutionary history and strong nonrandom associations among tightly linked sequence variation as determinants of the patterns of variation observed in natural populations. PMID:3026893

Artificial intelligence techniques for embryo and oocyte classification.

PubMed

Manna, Claudio; Nanni, Loris; Lumini, Alessandra; Pappalardo, Sebastiana

2013-01-01

One of the most relevant aspects in assisted reproduction technology is the possibility of characterizing and identifying the most viable oocytes or embryos. In most cases, embryologists select them by visual examination and their evaluation is totally subjective. Recently, due to the rapid growth in the capacity to extract texture descriptors from a given image, a growing interest has been shown in the use of artificial intelligence methods for embryo or oocyte scoring/selection in IVF programmes. This work concentrates the efforts on the possible prediction of the quality of embryos and oocytes in order to improve the performance of assisted reproduction technology, starting from their images. The artificial intelligence system proposed in this work is based on a set of Levenberg-Marquardt neural networks trained using textural descriptors (the local binary patterns). The proposed system was tested on two data sets of 269 oocytes and 269 corresponding embryos from 104 women and compared with other machine learning methods already proposed in the past for similar classification problems. Although the results are only preliminary, they show an interesting classification performance. This technique may be of particular interest in those countries where legislation restricts embryo selection. One of the most relevant aspects in assisted reproduction technology is the possibility of characterizing and identifying the most viable oocytes or embryos. In most cases, embryologists select them by visual examination and their evaluation is totally subjective. Recently, due to the rapid growth in our capacity to extract texture descriptors from a given image, a growing interest has been shown in the use of artificial intelligence methods for embryo or oocyte scoring/selection in IVF programmes. In this work, we concentrate our efforts on the possible prediction of the quality of embryos and oocytes in order to improve the performance of assisted reproduction technology, starting from their images. The artificial intelligence system proposed in this work is based on a set of Levenberg-Marquardt neural networks trained using textural descriptors (the 'local binary patterns'). The proposed system is tested on two data sets, of 269 oocytes and 269 corresponding embryos from 104 women, and compared with other machine learning methods already proposed in the past for similar classification problems. Although the results are only preliminary, they showed an interesting classification performance. This technique may be of particular interest in those countries where legislation restricts embryo selection. Copyright © 2012 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Application of reaction-diffusion models to cell patterning in Xenopus retina. Initiation of patterns and their biological stability.

PubMed

Shoaf, S A; Conway, K; Hunt, R K

1984-08-07

We have examined the behavior of two reaction-diffusion models, originally proposed by Gierer & Meinhardt (1972) and by Kauffman, Shymko & Trabert (1978), for biological pattern formation. Calculations are presented for pattern formation on a disc (approximating the geometry of a number of embryonic anlagen including the frog eye rudiment), emphasizing the sensitivity of patterns to changes in initial conditions and to perturbations in the geometry of the morphogen-producing space. Analysis of the linearized equations from the models enabled us to select appropriate parameters and disc size for pattern growth. A computer-implemented finite element method was used to solve the non-linear model equations reiteratively. For the Gierer-Meinhardt model, initial activation (varying in size over two orders of magnitude) of one point on the disc's edge was sufficient to generate the primary gradient. Various parts of the disc were removed (remaining only as diffusible space) from the morphogen-producing cycle to investigate the effects of cells dropping out of the cycle due to cell death or malfunction (single point removed) or differentiation (center removed), as occur in the Xenopus eye rudiment. The resulting patterns had the same general shape and amplitude as normal gradients. Nor did a two-fold increase in disc size affect the pattern-generating ability of the model. Disc fragments bearing their primary gradient patterns were fused (with gradients in opposite directions, but each parallel to the fusion line). The resulting patterns generated by the model showed many similarities to results of "compound eye" experiments in Xenopus. Similar patterns were obtained with the model of Kauffman's group (1978), but we found less stability of the pattern subject to simulations of central differentiation. However, removal of a single point from the morphogen cycle (cell death) did not result in any change. The sensitivity of the Kauffman et al. model to shape perturbations is not surprising since the model was originally designed to use shape and increasing size during growth to generate a sequence of transient patterns. However, the Gierer-Meinhardt model is remarkably stable even when subjected to a wide range of perturbations in the diffusible space, thus allowing it to cope with normal biological variability, and offering an exciting range of possibilities for reaction-diffusion models as mechanisms underlying the spatial patterns of tissue structures.

Consumer Perception of the Quality of Lamb and Lamb Confit

PubMed Central

2018-01-01

The patterns of food consumption in general and those of meat, in particular, are constantly changing. These changes are due not only to socioeconomic and cultural trends that affect the whole society but also to the specific lifestyles of consumer groups. Due to the importance of consumer lifestyle, the objectives of this study were (i) to identify the profiles of lamb meat consumers according to their orientation toward convenience, as defined by their eating and cooking habits; (ii) to characterize these profiles according to their socioeconomic characteristics and their preferences regarding the intrinsic and extrinsic quality signals of lamb meat; and (iii) to analyze the willingness to pay for lamb confit. In this study, four types of consumers have been differentiated according to their lifestyles related to lamb consumption. These groups, due to their characteristics, could be called “Gourmet”, “Disinterested”, “Conservative”, and “Basic”. The Gourmet group has characteristics that make it especially interesting to market a product such as lamb confit. However, this group is unaware of this product. Therefore, a possible strategy to expand the commercialization of light lamb and the confit product would be guided marketing to this niche market. PMID:29786652

Consumer Perception of the Quality of Lamb and Lamb Confit.

PubMed

Ripoll, Guillermo; Joy, Margalida; Panea, Begoña

2018-05-22

The patterns of food consumption in general and those of meat, in particular, are constantly changing. These changes are due not only to socioeconomic and cultural trends that affect the whole society but also to the specific lifestyles of consumer groups. Due to the importance of consumer lifestyle, the objectives of this study were (i) to identify the profiles of lamb meat consumers according to their orientation toward convenience, as defined by their eating and cooking habits; (ii) to characterize these profiles according to their socioeconomic characteristics and their preferences regarding the intrinsic and extrinsic quality signals of lamb meat; and (iii) to analyze the willingness to pay for lamb confit. In this study, four types of consumers have been differentiated according to their lifestyles related to lamb consumption. These groups, due to their characteristics, could be called "Gourmet", "Disinterested", "Conservative", and "Basic". The Gourmet group has characteristics that make it especially interesting to market a product such as lamb confit. However, this group is unaware of this product. Therefore, a possible strategy to expand the commercialization of light lamb and the confit product would be guided marketing to this niche market.

The measurement capabilities of cross-sectional profile of Nanoimprint template pattern using small angle x-ray scattering

NASA Astrophysics Data System (ADS)

Yamanaka, Eiji; Taniguchi, Rikiya; Itoh, Masamitsu; Omote, Kazuhiko; Ito, Yoshiyasu; Ogata, Kiyoshi; Hayashi, Naoya

2016-05-01

Nanoimprint lithography (NIL) is one of the most potential candidates for the next generation lithography for semiconductor. It will achieve the lithography with high resolution and low cost. High resolution of NIL will be determined by a high definition template. Nanoimprint lithography will faithfully transfer the pattern of NIL template to the wafer. Cross-sectional profile of the template pattern will greatly affect the resist profile on the wafer. Therefore, the management of the cross-sectional profile is essential. Grazing incidence small angle x-ray scattering (GI-SAXS) technique has been proposed as one of the method for measuring cross-sectional profile of periodic nanostructure pattern. Incident x-rays are irradiated to the sample surface with very low glancing angle. It is close to the critical angle of the total reflection of the x-ray. The scattered x-rays from the surface structure are detected on a two-dimensional detector. The observed intensity is discrete in the horizontal (2θ) direction. It is due to the periodicity of the structure, and diffraction is observed only when the diffraction condition is satisfied. In the vertical (β) direction, the diffraction intensity pattern shows interference fringes reflected to height and shape of the structure. Features of the measurement using x-ray are that the optical constant for the materials are well known, and it is possible to calculate a specific diffraction intensity pattern based on a certain model of the cross-sectional profile. The surface structure is estimated by to collate the calculated diffraction intensity pattern that sequentially while changing the model parameters with the measured diffraction intensity pattern. Furthermore, GI-SAXS technique can be measured an object in a non-destructive. It suggests the potential to be an effective tool for product quality assurance. We have developed a cross-sectional profile measurement of quartz template pattern using GI-SAXS technique. In this report, we will report the measurement capabilities of GI-SAXS technique as a cross-sectional profile measurement tool of NIL quartz template pattern.

Visualizing a possible atmospheric teleconnection associated with UK floods in autumn 2000

NASA Astrophysics Data System (ADS)

Pall, P.; Bensema, K.; Stone, D.; Wehner, M. F.; Bethel, W.; Joy, K.

2012-12-01

Severe floods occurred across England and Wales during the record-wet autumn of the year 2000. Recently Pall et al. (2011) demonstrated that the risk of such floods occurring at that time substantially increased as a result of anthropogenic greenhouse gas emissions, and that the synoptic weather system associated with the floods was a common but anomalously strong 'Scandinavia' atmospheric circulation pattern (a Rossby-wave-like train of tropospheric anomalies in geopotential height, extending from the subtropical Atlantic across Eurasia, with a cyclone over the UK and a strong anticyclone over Scandinavia). Blackburn and Hoskins (2001) suggest that this pattern was itself catalyzed by an anomalous upper-tropospheric flow of air: originating with an ascent of air due to convection over warm sea surface temperatures in the western Tropical Pacific, and ending in a descent of air over the Amazon in the proposed source region of the Scandinavia pattern. However, evidence for this so-called 'teleconnection' is not entirely clear in the idealised climate models they used. Here we use visualization techniques to search for this teleconnection in the simulations generated with the more comprehensive seasonal-forecast-resolution climate model of Pall et al. (2011) -- by identifying anomalous streamflow patterns and using the UV-CDAT software developed at Berkeley Lab to do so. Furthermore, since several thousand simulations were generated (in order to capture the rare flood event), totaling hundreds of GB in size, we use paralleisation techniques to perform this search efficiently.

Skeletal muscle proteins: a new approach to delimitate the time since death.

PubMed

Foditsch, Elena Esra; Saenger, Alexandra Maria; Monticelli, Fabio Carlo

2016-03-01

Skeletal muscle tissue is proposed as a forensic model tissue with strong potential, as it is easily accessible and its true-to-life state structure and function is well known. Despite this strong potential, skeletal muscle degradation studies are rare. The aim of this study was to test if a skeletal muscle-based protein analysis is applicable to delimitate the time since death. Under standard conditions, two pigs were stored either at 22 °C for 5 days or 4 °C for 21 days. Their Mm. biceps femori were sampled periodically for analyses of ten skeletal muscle proteins postmortem. All analyzed proteins can serve as markers for a delimitation of the time since death. Desmin, nebulin, titin, and SERCA 1 displayed distinct protein patterns at certain points of time. The other five proteins, α-actinin, calsequestrin-1, laminin, troponin T-C, and SERCA 2, showed no degradation patterns within the analyzed postmortem time frame. Referring to specific skeletal muscle proteins, results showed short-term stabilities for just a minority of analyzed proteins, while the majority of investigated proteins displayed characteristics as long-term markers. Due to specific patterns and the possibility to determine definite constraints of the presence, absence, or pattern alterations of single proteins, the feasibility of porcine skeletal muscle as forensic model tissue is outlined and the potential of skeletal muscle as forensic model tissue is underlined, especially with respect to later postmortem phases, which so far lack feasible methods to delimitate the time since death.

Patterns, severity, and management of maxillofacial injuries in a suburban South Western Nigeria tertiary center.

PubMed

Ogunmuyiwa, Stella Aimiede; Gbolahan, Olalere Omoyosola; Ayantunde, Abiodun Abraham; Odewabi, Adenike Abidemi

2015-01-01

Trauma remains a leading cause of maxillofacial injury globally. Changing etiological factors and patterns of maxillofacial injury continue to be reported and are largely modulated by socio-geographic and environmental factors. It is important to have an in-depth understanding of the pattern and etiology in a particular region before effective preventive measures can be developed. The aim was to evaluate the patterns, etiological factors, and management of maxillofacial injuries in Ogun state, Nigeria. A prospective descriptive cohort study of all consecutive patients that presented with maxillofacial injuries at our center between January and December 2013. Information about demographic data, types of maxillofacial and associated injury, etiology of injury, treatment received and complications were collected and analyzed. Seventy patients presented with maxillofacial injury during the study period with a male to female ratio of 4:1. The age range was 9 months to 60 years with a mean of 30.11 ± standard deviation 14.97 years. Majority of the facial fractures were due to motorcycle related crashes. There were 57.1% mandibular fractures and 55.7% middle third fractures. Closed reduction with maxillo-mandibular fixation was the major method of treatment of facial fractures. Postoperative complications were observed in 11.4% of patients. Road traffic crashes (RTCs) remain the leading etiological factor of maxillofacial injuries in our center. Enforcement of stricter traffic regulations and possibly replacement of motorcycles with tricycles for commercial transportation may help to reduce the incidence of RTCs.

Development of Low Carbon Niobium Bearing High Strength F-B Dual Phase Steel with High Hole Expansion Property

NASA Astrophysics Data System (ADS)

Zhang, Lin; Xia, Ming-sheng; Xiong, Zi-liu; Du, Yan-bing; Qiao, Zhi-ming; Zhang, Hong-bo

In the study a low carbon niobium bearing high strength F-B dual phase automobile steel with high hole expansion property has been investigated. Steels of different chemical composition have been investigated by simulation experiments of controlled rolling and cooling process to study the influences of chemical elements, especially for C,Nb and Ti, and cooling pattern on the mechanical properties, flangeability and microstructure of strips. So-called 3-stages cooling pattern was adopted in simulation experiments, combining ultra fast cooling in first stage, air cooling in middle stage and fast cooling in the last stage, and at the end of run-out table the temperature of rolled pieces drop to below Bs point. Optical microstructure and SEM morphology have been observed. Results indicate that it is possible to obtain dual phase microstructure of polygonal ferrite plus bainite in adopting 3-stages cooling pattern. The low temperature coiling method using 3-step controlled cooling pattern after hot rolling is effective to produce low carbon Nb bearing steel with high balance of strength-ductility-flangeability, in addition, higher carbon content of steel tend to be detrimental to flangeability of steel, due to much carbide precipitation at ferrite boundary. Based on the results of simulation experiments mill trial has been carried out and hot rolled high strength steel with tensile strength higher as 600Mpa and hole expansion ratio higher as 100% has been developed successfully.

Regular Nanoscale Protein Patterns via Directed Adsorption through Self-Assembled DNA Origami Masks.

PubMed

Ramakrishnan, Saminathan; Subramaniam, Sivaraman; Stewart, A Francis; Grundmeier, Guido; Keller, Adrian

2016-11-16

DNA origami has become a widely used method for synthesizing well-defined nanostructures with promising applications in various areas of nanotechnology, biophysics, and medicine. Recently, the possibility to transfer the shape of single DNA origami nanostructures into different materials via molecular lithography approaches has received growing interest due to the great structural control provided by the DNA origami technique. Here, we use ordered monolayers of DNA origami nanostructures with internal cavities on mica surfaces as molecular lithography masks for the fabrication of regular protein patterns over large surface areas. Exposure of the masked sample surface to negatively charged proteins results in the directed adsorption of the proteins onto the exposed surface areas in the holes of the mask. By controlling the buffer and adsorption conditions, the protein coverage of the exposed areas can be varied from single proteins to densely packed monolayers. To demonstrate the versatility of this approach, regular nanopatterns of four different proteins are fabricated: the single-strand annealing proteins Redβ and Sak, the iron-storage protein ferritin, and the blood protein bovine serum albumin (BSA). We furthermore demonstrate the desorption of the DNA origami mask after directed protein adsorption, which may enable the fabrication of hierarchical patterns composed of different protein species. Because selectivity in adsorption is achieved by electrostatic interactions between the proteins and the exposed surface areas, this approach may enable also the large-scale patterning of other charged molecular species or even nanoparticles.

Circular flow patterns induced by ciliary activity in reconstituted human bronchial epithelium

NASA Astrophysics Data System (ADS)

Viallat, Annie; Khelloufi, Kamel; Gras, Delphine; Chanez, Pascal; Aix Marseille Univ., CNRS, CINaM, Marseille, France Team; Aix Marseille Univ., CNRS, Inserm, LAI, Marseille, France Team

2016-11-01

Mucociliary clearance is the transport at the surface of airways of a complex fluid layer, the mucus, moved by the beats of microscopic cilia present on epithelial ciliated cells. We explored the coupling between the spatial organisation and the activity of cilia and the transport of surface fluids on reconstituted cultures of human bronchial epithelium at air-liquid interface, obtained by human biopsies. We reveal the existence of stable local circular surface flow patterns of mucus or Newtonian fluid at the epithelium surface. We find a power law over more than 3 orders of magnitude showing that the average ciliated cell density controls the size of these flow patterns, and, therefore the distance over which mucus can be transported. We show that these circular flow patterns result from the radial linear increase of the local propelling forces (due to ciliary beats) on each flow domain. This linear increase of local forces is induced by a fine self-regulation of both cilia density and orientation of ciliary beats. Local flow domains grow and merge during ciliogenesis to provide macroscopic mucus transport. This is possible only when the viscoelastic mucus continuously exerts a shear stress on beating cilia, revealing a mechanosensitive function of cilia. M. K. Khelloufi thanks the society MedBioMed for financial support. This work was supported by the ANR MUCOCIL project, Grant ANR-13-BSV5-0015 of the French Agence Nationale de la Recherche.

Habitat and landscape characteristics underlying anuran community structure along an urban-rural gradient.

PubMed

Pillsbury, Finn C; Miller, James R

2008-07-01

Urbanization has been cited as an important factor in worldwide amphibian declines, and although recent work has illustrated the important influence of broad-scale ecological patterns and processes on amphibian populations, little is known about the factors structuring amphibian communities in urban landscapes. We therefore examined amphibian community responses to wetland habitat availability and landscape characteristics along an urban-rural gradient in central Iowa, USA, a region experiencing rapid suburban growth. We conducted call surveys at 61 wetlands to estimate anuran calling activity, and quantified wetland habitat structure and landscape context. We used canonical correspondence analysis (CCA) to examine patterns in anuran community structure and identify the most important variables associated with those patterns. Urban density at the landscape scale had a significant negative influence on overall anuran abundance and diversity. While every species exhibited a decrease in abundance with increasing urban density, this pattern was especially pronounced for species requiring post-breeding upland habitats. Anurans most affected by urbanization were those associated with short hydroperiods, early breeding activity, and substantial upland habitat use. We suggest that broad-scale landscape fragmentation is an important factor underlying anuran community structure in this region, possibly due to limitations on the accessibility of otherwise suitable habitat in fragmented urban landscapes. This study underscores the importance of a regional approach to amphibian conservation in urban and urbanizing areas; in fragmented landscapes, a network of interconnected wetland and upland habitats may be more likely to support a successful, diverse anuran community than will isolated sites.

A Model of the Temporal Variability of Optical Light from Extrasolar Terrestrial Planets

NASA Astrophysics Data System (ADS)

Ford, E. B.; Seager, S.; Turner, E. L.

2001-05-01

New observatories such as TPF (NASA) and Darwin (ESA) are being designed to detect light directly from terrestrial-mass planets. Such observations will provide new data to constrain theories of planet formation and may identify the possible presence of liquid water and even spectroscopic signatures suggestive of life. We model the light scattered by Earth-like planets focusing on temporal variability due to planetary rotation and weather. Since a majority of the scattered light comes from only a small fraction of the planet's surface, significant variations in brightness are possible. The variations can be as large as a factor of two for a cloud-free planet which has a range of albedos similar to those of the different surfaces found on Earth. If a significant fraction of the observed light is scattered by the planet's atmosphere, including clouds, then the amplitude of variations due to surface features will be diluted. Atmospheric variability (e.g. clouds) itself is extremely interesting because it provides evidence for weather. The planet's rotation period, fractional ice and cloud cover, gross distribution of land and water on the surface, large scale weather patterns, large regions of unusual reflectivity or color (such as major desserts or vegetation's "red edge") as well as the geometry of its spin, orbit, and illumination relative to the observer all have substantial effects on the planet's rotational light curve.

Empirical orthogonal function analysis of cloud-containing coastal zone color scanner images of northeastern North American coastal waters

NASA Technical Reports Server (NTRS)

Eslinger, David L.; O'Brien, James J.; Iverson, Richard L.

1989-01-01

Empirical-orthogonal-function (EOF) analyses were carried out on 36 images of the Mid-Atlantic Bight and the Gulf of Maine, obtained by the CZCS aboard Nimbus 7 for the time period from February 28 through July 9, 1979, with the purpose of determining pigment concentrations in coastal waters. The EOF procedure was modified so as to include images with significant portions of data missing due to cloud obstruction, making it possible to estimate pigment values in areas beneath clouds. The results of image analyses explained observed variances in pigment concentrations and showed a south-to-north pattern corresponding to an April Mid-Atlantic Bight bloom and a June bloom over Nantucket Shoals and Platts Bank.

Optical, photonic and optoelectronic properties of graphene, h-NB and their hybrid materials

NASA Astrophysics Data System (ADS)

Wang, Jingang; Ma, Fengcai; Liang, Wenjie; Wang, Rongming; Sun, Mengtao

2017-06-01

Because of the linear dispersion relation and the unique structure of graphene's Dirac electrons, which can be tuned the ultra-wide band, this enables more applications in photonics, electronics and plasma optics. As a substrate, hexagonal boron nitride (h-BN) has an atomic level flat surface without dangling bonds, a weak doping effect and a response in the far ultraviolet area. So the graphene/h-BN heterostructure is very attractive due to its unique optical electronics characteristics. Graphene and h-BN which are stacked in different ways could open the band gap of graphene, and form a moiré pattern for graphene on h-BN and the superlattice in the Brillouin zone, which makes it possible to build photoelectric devices.

Binge drinking: Burden of liver disease and beyond

PubMed Central

Llerena, Susana; Arias-Loste, María Teresa; Puente, Angela; Cabezas, Joaquín; Crespo, Javier; Fábrega, Emilio

2015-01-01

The consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts (in the form of violence or traffic accidents) and its organic impact (affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society. PMID:26644814

Repeating Patterns in Kindergarten: Findings from Children's Enactments of Two Activities

ERIC Educational Resources Information Center

Tsamir, Pessia; Tirosh, Dina; Levenson, Esther S.; Barkai, Ruthi; Tabach, Michal

2017-01-01

This paper describes kindergarten children's engagement with two patterning activities. The first activity includes two tasks in which children are asked to choose possible ways for extending two different repeating patterns and the second activity calls for comparing different pairs of repeating patterns. Children's recognition of the unit of…

Hierarchical micro- and nanofabrication by pattern-directed contact instabilities of thin viscoelastic films

NASA Astrophysics Data System (ADS)

Ghosh, Abir; Bandyopadhyay, Dipankar; Sarkar, Jayati; Sharma, Ashutosh

2017-12-01

A surface of a thin viscoelastic film forms spinodal patterns when brought in contact proximity of another surface due to the dominance of destabilizing intermolecular interaction over the stabilizing elastic and surface tension forces. In this study, we theoretically explore such contact instabilities of a thin viscoelastic film, wherein the patterns generated on the surface of the film is developed with the help of a contactor decorated with periodic physical, chemical, and physicochemical features on the surface. The nonlinear analysis shown here considers the movement of the patterned contactor during the adhesion and debonding processes, which is unlike most of the previous works where the contactor is considered to be stationary. The simulations reveal that the amplitude and periodicity of the patterns decorated on the contactor together with the contactor speed can be the key parameters to stimulate pattern formation on the film surface alongside causing changeover of the various modes of debonding of the surfaces. In particular, the ratio of the elastic to viscous compliances of the film is found to play a critical role to stimulate the changeover of the modes from catastrophic to peeling or coalescence. The study uncovers that a higher wettability contrast across the patterned contactor leads to the catastrophic collapse of the patterns decorated on the film surface when the contactor debonds at a moderate speed. In comparison, a moderately high wettability contrast alongside a faster withdrawal speed of the contactor results in the gradual peeling of columns during the debonding cycle. Remarkably, a higher withdrawal speed of the contactor from the film-proximity can increase the aspect ratio of the patterns fabricated on the film surface to about fourfold during the peeling mode of debonding. The results show the importance of the usage of patterned contactors, their controlled movement, and extent of elastic to viscous compliance ratio of the film for the improvement of the aspect ratio of the patterns developed using the elastic contact lithography of the thin viscoelastic films. The simulations also reveal the possibilities of the fabrication of biomimetic micro- or nanostructures such as columns, holes, cavities, or a combination of these patterns with large-area ordering employing the patterned contactors. A few example cases are shown to highlight the capacity of the proposed methodology for the fabrication of higher aspect ratio hierarchical micro- or nanostructures.

Notch and Delta mRNAs in early-stage and mid-stage Drosophila embryos exhibit complementary patterns of protein producing potentials

PubMed Central

Shepherd, Andrew; Wesley, Uma; Wesley, Cedric

2010-01-01

Notch and Delta proteins generate Notch signaling that specifies cell fates during animal development. There is an intriguing phenomenon in Drosophila embryogenesis that has not received much attention and whose significance to embryogenesis is unknown. Notch and Delta mRNAs expressed in early-stage embryos are shorter than their counterparts in mid-stage embryos. We show here that the difference in sizes is due to mRNA 3′ processing at alternate polyadenylation sites. While the early-stage Notch mRNA has a lower protein-producing potential than the mid-stage Notch mRNA, the early-stage Delta mRNA has a higher protein-producing potential than the mid-stage Delta mRNA. Our data can explain the complementary patterns of Notch and Delta protein levels in early-stage and mid-stage embryos. Our data also raise the possibility that the manner and regulation of Notch signaling change in the course of embryogenesis and that this change is effected by 3′ UTR and mRNA 3′ processing factors. PMID:20201103

Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease.

PubMed

Porter, John B

2009-01-01

The pathophysiological consequences of transfusional iron overload largely reflect the pattern of excess iron distribution and include cardiomyopathy, endocrinopathy, cirrhosis, and hepatocellular carcinoma. Since the introduction of desferrioxamine (DFO) in the late 1970s, these complications have fallen substantially but approximately half of the chelated adult patients with thalassemia major (TM) still show evidence of increased myocardial iron loading by MRI. An understanding of the factors that determine the propensity to extrahepatic iron distribution may be a key to minimizing the pathophysiological consequences of transfusional iron overload. Transfused patients with sickle cell disease (SCD) appear less likely to develop these extrahepatic complications, possibly because plasma nontransferrin-bound iron (NTBI) levels are typically lower than in TM patients at matched levels of iron loading. Other mechanisms that may reduce the extrahepatic iron distribution in SCD include raised plasma hepcidin due to chronic inflammation, lower growth differentiation factor 15 (GDF15) levels because of less ineffective erythropoiesis (IE), and induction of heme oxygenase (HO1) by intravascular hemolysis. Further understanding of these mechanisms may help in designing strategies to decrease extrahepatic iron distribution in TM.

Photo-thermal and cytotoxic properties of inkjet-printed copper sulfide films on biocompatible latex coated substrates

NASA Astrophysics Data System (ADS)

Sarfraz, Jawad; Borzenkov, Mykola; Niemelä, Erik; Weinberger, Christian; Törngren, Björn; Rosqvist, Emil; Collini, Maddalena; Pallavicini, Piersandro; Eriksson, John; Peltonen, Jouko; Ihalainen, Petri; Chirico, Giuseppe

2018-03-01

Inkjet-printing of metal nanoparticles is a particularly promising technique for the fabrication and modification of surfaces with a multifunctional nature. Recently copper sulfide nanoparticles (CuS NPs) have attracted wide interest due to a range of valuable properties including long term stability, photo-thermal activity, ease of synthesis and low cost. In the present study, printed CuS patterns were successfully fabricated on latex coated paper substrates and characterized by means of atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), UV-Vis-NIR spectroscopy, and grazing incidence X-ray diffraction (GID). The resulted patterns displayed pronounced photo-thermal effect under Near Infrared Irradiation (NIR) even with relatively low laser power. Finally, by utilizing an automated real-time imaging platform it was possible to verify that the CuS printed film was not cytotoxic to human dermal fibroblast cells (HDF). The pronounced photo-thermal properties and nontoxic nature of these printed low-cost flexible CuS films make them promising candidates for fabrication of devices with localized photo-thermal effect suitable for biomedical applications.

Efficient Data Mining for Local Binary Pattern in Texture Image Analysis

PubMed Central

Kwak, Jin Tae; Xu, Sheng; Wood, Bradford J.

2015-01-01

Local binary pattern (LBP) is a simple gray scale descriptor to characterize the local distribution of the grey levels in an image. Multi-resolution LBP and/or combinations of the LBPs have shown to be effective in texture image analysis. However, it is unclear what resolutions or combinations to choose for texture analysis. Examining all the possible cases is impractical and intractable due to the exponential growth in a feature space. This limits the accuracy and time- and space-efficiency of LBP. Here, we propose a data mining approach for LBP, which efficiently explores a high-dimensional feature space and finds a relatively smaller number of discriminative features. The features can be any combinations of LBPs. These may not be achievable with conventional approaches. Hence, our approach not only fully utilizes the capability of LBP but also maintains the low computational complexity. We incorporated three different descriptors (LBP, local contrast measure, and local directional derivative measure) with three spatial resolutions and evaluated our approach using two comprehensive texture databases. The results demonstrated the effectiveness and robustness of our approach to different experimental designs and texture images. PMID:25767332

Optimize Operating Conditions on Fine Particle Grinding Process with Vertically Stirred Media Mill

NASA Astrophysics Data System (ADS)

Yang, Yang; Rowson, Neil; Ingram, Andy

2016-11-01

Stirred media mill recently is commonly utilized among mining process due to its high stressing intensity and efficiency. However, the relationship between size reduction and flow pattern within the mixing pot is still not fully understand. Thus, this work investigates fine particle grinding process within vertically stirred media mills by altering stirrer geometry, tip speed and solids loading. Positron Emitting Particle Tracking (PEPT) technology is utilized to plot routine of particles velocity map. By tacking trajectory of a single particle movement within the mixing vessel, the overall flow pattern is possible to be plotted. Ground calcium carbonate, a main product of Imerys, is chosen as feeding material (feed size D80 30um) mixed with water to form high viscous suspension. To obtain fine size product (normally D80 approximately 2um), large amount of energy is drawn by grinding mill to break particles through impact, shear attrition or compression or a combination of them. The results indicate higher energy efficient is obtained with more dilute suspension. The optimized stirrer proves more energy-saving performance by altering the slurry circulate. Imerys Minerals Limited.

Dazzle camouflage, target tracking, and the confusion effect.

PubMed

Hogan, Benedict G; Cuthill, Innes C; Scott-Samuel, Nicholas E

2016-01-01

The influence of coloration on the ecology and evolution of moving animals in groups is poorly understood. Animals in groups benefit from the "confusion effect," where predator attack success is reduced with increasing group size or density. This is thought to be due to a sensory bottleneck: an increase in the difficulty of tracking one object among many. Motion dazzle camouflage has been hypothesized to disrupt accurate perception of the trajectory or speed of an object or animal. The current study investigates the suggestion that dazzle camouflage may enhance the confusion effect. Utilizing a computer game style experiment with human predators, we found that when moving in groups, targets with stripes parallel to the targets' direction of motion interact with the confusion effect to a greater degree, and are harder to track, than those with more conventional background matching patterns. The findings represent empirical evidence that some high-contrast patterns may benefit animals in groups. The results also highlight the possibility that orientation and turning may be more relevant in the mechanisms of dazzle camouflage than previously recognized.

HARMONY: a server for the assessment of protein structures

PubMed Central

Pugalenthi, G.; Shameer, K.; Srinivasan, N.; Sowdhamini, R.

2006-01-01

Protein structure validation is an important step in computational modeling and structure determination. Stereochemical assessment of protein structures examine internal parameters such as bond lengths and Ramachandran (φ,ψ) angles. Gross structure prediction methods such as inverse folding procedure and structure determination especially at low resolution can sometimes give rise to models that are incorrect due to assignment of misfolds or mistracing of electron density maps. Such errors are not reflected as strain in internal parameters. HARMONY is a procedure that examines the compatibility between the sequence and the structure of a protein by assigning scores to individual residues and their amino acid exchange patterns after considering their local environments. Local environments are described by the backbone conformation, solvent accessibility and hydrogen bonding patterns. We are now providing HARMONY through a web server such that users can submit their protein structure files and, if required, the alignment of homologous sequences. Scores are mapped on the structure for subsequent examination that is useful to also recognize regions of possible local errors in protein structures. HARMONY server is located at PMID:16844999

Organic-inorganic hybrid resists for EUVL

NASA Astrophysics Data System (ADS)

Singh, Vikram; Kalyani, Vishwanath; Satyanarayana, V. S. V.; Pradeep, Chullikkattil P.; Ghosh, Subrata; Sharma, Satinder; Gonsalves, Kenneth E.

2014-03-01

Herein, we describe preliminary results on organic-inorganic hybrid photoresists, capable of showing line patterns up to 16 nm under e-beam exposure studies, prepared by incorporating polyoxometalates (POMs) clusters into organic photoresist materials. Various Mo and W based clusters such as (TBA)2[Mo6O19], (TBA)5(H)[P2V3W15O62] and (TBA)4[P2Mo18O61] (where TBA = tetrabutyl ammonium counter ion) have been incorporated into PMMA matrix by mixing POM solutions and standard PMMA polymer in anisole (MW ~ 95000, MicroChem) in 1:33 w/v ratio. E-beam exposure followed by development with MIBK solutions showed that these new organic-inorganic hybrid photoresists show good line patterns upto 16 nm, which were not observed in the case of control experiments done on pure PMMA polymer resist. The observed enhancement of resist properties in the case of hybrid resists could possibly be due to a combination of features imparted to the resist by the POM clusters such as increased sensitivity, etch resistance and thermal stability.

Ultra-broadband Tunable Resonant Light Trapping in a Two-dimensional Randomly Microstructured Plasmonic-photonic Absorber

PubMed Central

Liu, Zhengqi; Liu, Long; Lu, Haiyang; Zhan, Peng; Du, Wei; Wan, Mingjie; Wang, Zhenlin

2017-01-01

Recently, techniques involving random patterns have made it possible to control the light trapping of microstructures over broad spectral and angular ranges, which provides a powerful approach for photon management in energy efficiency technologies. Here, we demonstrate a simple method to create a wideband near-unity light absorber by introducing a dense and random pattern of metal-capped monodispersed dielectric microspheres onto an opaque metal film; the absorber works due to the excitation of multiple optical and plasmonic resonant modes. To further expand the absorption bandwidth, two different-sized metal-capped dielectric microspheres were integrated into a densely packed monolayer on a metal back-reflector. This proposed ultra-broadband plasmonic-photonic super absorber demonstrates desirable optical trapping in dielectric region and slight dispersion over a large incident angle range. Without any effort to strictly control the spatial arrangement of the resonant elements, our absorber, which is based on a simple self-assembly process, has the critical merits of high reproducibility and scalability and represents a viable strategy for efficient energy technologies. PMID:28256599

Municipal mortality due to thyroid cancer in Spain

PubMed Central

Lope, Virginia; Pollán, Marina; Pérez-Gómez, Beatriz; Aragonés, Nuria; Ramis, Rebeca; Gómez-Barroso, Diana; López-Abente, Gonzalo

2006-01-01

Background Thyroid cancer is a tumor with a low but growing incidence in Spain. This study sought to depict its spatial municipal mortality pattern, using the classic model proposed by Besag, York and Mollié. Methods It was possible to compile and ascertain the posterior distribution of relative risk on the basis of a single Bayesian spatial model covering all of Spain's 8077 municipal areas. Maps were plotted depicting standardized mortality ratios, smoothed relative risk (RR) estimates, and the posterior probability that RR > 1. Results From 1989 to 1998 a total of 2,538 thyroid cancer deaths were registered in 1,041 municipalities. The highest relative risks were mostly situated in the Canary Islands, the province of Lugo, the east of La Coruña (Corunna) and western areas of Asturias and Orense. Conclusion The observed mortality pattern coincides with areas in Spain where goiter has been declared endemic. The higher frequency in these same areas of undifferentiated, more aggressive carcinomas could be reflected in the mortality figures. Other unknown genetic or environmental factors could also play a role in the etiology of this tumor. PMID:17173668

Altered reward learning and hippocampal connectivity following psychosocial stress.

PubMed

Kruse, Onno; Tapia León, Isabell; Stalder, Tobias; Stark, Rudolf; Klucken, Tim

2018-05-01

Acute stress has a profound influence on learning, as has been demonstrated in verbal learning or fear conditioning. However, its effect on appetitive conditioning is still unclear. Fear conditioning research suggests the possibility of overgeneralization of conditioning to the CS- under acute stress due to its effect on prefrontal and hippocampal processing. In this study, participants (N = 56 males) were subjected to the Trier Social Stress Test or a placebo version. After that, all participants underwent an appetitive conditioning paradigm in the fMRI, in which one neutral cue (CS+) was repeatedly paired with reward, while another (CS-) was not. Importantly, the stress-group revealed overgeneralization of conditioning to the CS- on the behavioral level. On the neural level, stressed participants showed increased connectivity between the hippocampus and amygdala, vACC, and OFC, which maintain specificity of conditioning and also showed reduced differential activation. The results indicate overgeneralization of appetitive conditioning promoted by maladaptive balancing of pattern separation and pattern completion in the hippocampus under acute stress and are discussed with respect to clinical implications. Copyright © 2017 Elsevier Inc. All rights reserved.

Physical and biological properties of U. S. standard endotoxin EC after exposure to ionizing radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Csako, G.; Elin, R.J.; Hochstein, H.D.

Techniques that reduce the toxicity of bacterial endotoxins are useful for studying the relationship between structure and biological activity. We used ionizing radiation to detoxify a highly refined endotoxin preparation. U.S. standard endotoxin EC. Dose-dependent changes occurred by exposure to /sup 60/Co-radiation in the physical properties and biological activities of the endotoxin. Sodium dodecyl sulfate-polyacrylamide slab gel electrophoresis showed gradual loss of the polysaccharide components (O-side chain and R-core) from the endotoxin molecules. In contrast, although endotoxin revealed a complex absorption pattern in the UV range, radiation treatment failed to modify that pattern. Dose-related destruction of the primary toxic component,more » lipid A, was suggested by the results of activity tests: both the pyrogenicity and limulus reactivity of the endotoxin were destroyed by increasing doses of radiation. The results indicate that the detoxification is probably due to multiple effects of the ionizing radiation on bacterial lipopolysaccharides, and the action involves (i) the destruction of polysaccharide moieties and possibly (ii) the alteration of lipid A component of the endotoxin molecule.« less

A comparative study of the hydrogen-bonding patterns and prototropism in solid 2-thiocytosine (potential antileukemic agent) and cytosine, as studied by 1H-14N NQDR and QTAIM/ DFT.

PubMed

Latosińska, Jolanta N; Seliger, Janez; Zagar, Veselko; Burchardt, Dorota V

2012-01-01

A potential antileukemic and anticancer agent, 2-thiocytosine (2-TC), has been studied experimentally in the solid state by (1)H-(14)N NMR-NQR double resonance (NQDR) and theoretically by the quantum theory of atoms in molecules (QTAIM)/density functional theory (DFT). Eighteen resonance frequencies on (14)N were detected at 180 K and assigned to particular nitrogen sites (-NH(2), -N=, and -NH-) in 2-thiocytosine. Factors such as the nonequivalence of molecules (connected to the duplication of sites) and possible prototropic tautomerism (capable of modifying the type of site due to proton transfer) were taken into account during frequency assignment. The result of replacing oxygen with sulfur, which leads to changes in the intermolecular interaction pattern and molecular aggregation, is discussed. This study demonstrates the advantages of combining NQDR and DFT to extract detailed information on the H-bonding properties of crystals with complex H-bonding networks. Solid-state properties were found to have a profound impact on the stabilities and reactivities of both compounds.

No evidence for orbital loop currents in charge-ordered YBa2Cu3O6 +x from polarized neutron diffraction

NASA Astrophysics Data System (ADS)

Croft, T. P.; Blackburn, E.; Kulda, J.; Liang, Ruixing; Bonn, D. A.; Hardy, W. N.; Hayden, S. M.

2017-12-01

It has been proposed that the pseudogap state of underdoped cuprate superconductors may be due to a transition to a phase which has circulating currents within each unit cell. Here, we use polarized neutron diffraction to search for the corresponding orbital moments in two samples of underdoped YBa2Cu3O6 +x with doping levels p =0.104 and 0.123. In contrast to some other reports using polarized neutrons, but in agreement with nuclear magnetic resonance and muon spin rotation measurements, we find no evidence for the appearance of magnetic order below 300 K. Thus, our experiment suggests that such order is not an intrinsic property of high-quality cuprate superconductor single crystals. Our results provide an upper bound for a possible orbital loop moment which depends on the pattern of currents within the unit cell. For example, for the CC-θI I pattern proposed by Varma, we find that the ordered moment per current loop is less than 0.013 μB for p =0.104 .

Intelligent-based Structural Damage Detection Model

NASA Astrophysics Data System (ADS)

Lee, Eric Wai Ming; Yu, Kin Fung

2010-05-01

This paper presents the application of a novel Artificial Neural Network (ANN) model for the diagnosis of structural damage. The ANN model, denoted as the GRNNFA, is a hybrid model combining the General Regression Neural Network Model (GRNN) and the Fuzzy ART (FA) model. It not only retains the important features of the GRNN and FA models (i.e. fast and stable network training and incremental growth of network structure) but also facilitates the removal of the noise embedded in the training samples. Structural damage alters the stiffness distribution of the structure and so as to change the natural frequencies and mode shapes of the system. The measured modal parameter changes due to a particular damage are treated as patterns for that damage. The proposed GRNNFA model was trained to learn those patterns in order to detect the possible damage location of the structure. Simulated data is employed to verify and illustrate the procedures of the proposed ANN-based damage diagnosis methodology. The results of this study have demonstrated the feasibility of applying the GRNNFA model to structural damage diagnosis even when the training samples were noise contaminated.

Becker's rational addiction theory: An empirical test with price elasticities for distilled spirits in Denmark 1911-31.

PubMed

Skog, Ole-Jørgen; Melberg, Hans Olav

2006-10-01

To test an implication of Becker's rational addiction theory, namely that price changes will lead both to simultaneous consumption changes as well as lagged changes (and potentially also immediate changes if future changes in prices are anticipated). Time-series analysis, first of aggregate sales of distilled spirits and prices, controlled for gross national product (GNP), and secondly of deaths from delirium tremens. Denmark 1911-31. Price changes were very large in the period 1916-18 due to shortages during World War I, and the Danish case can be conceived as a natural experiment. No evidence for lagged price effects in the expected direction was found. On the contrary, the evidence pointed in the opposite direction. The immediate reduction in sales following rising prices are, to some degree, counteracted by an adjustment in the opposite direction the following year. The delirium tremens data confirm this pattern. Becker's theory is not confirmed. Several possible explanations are discussed. If the pattern observed in these data is representative of a more general mechanism, current price elasticity estimates may be too high, by ignoring lagged compensatory effects.

Age-related impairments in active learning and strategic visual exploration.

PubMed

Brandstatt, Kelly L; Voss, Joel L

2014-01-01

Old age could impair memory by disrupting learning strategies used by younger individuals. We tested this possibility by manipulating the ability to use visual-exploration strategies during learning. Subjects controlled visual exploration during active learning, thus permitting the use of strategies, whereas strategies were limited during passive learning via predetermined exploration patterns. Performance on tests of object recognition and object-location recall was matched for younger and older subjects for objects studied passively, when learning strategies were restricted. Active learning improved object recognition similarly for younger and older subjects. However, active learning improved object-location recall for younger subjects, but not older subjects. Exploration patterns were used to identify a learning strategy involving repeat viewing. Older subjects used this strategy less frequently and it provided less memory benefit compared to younger subjects. In previous experiments, we linked hippocampal-prefrontal co-activation to improvements in object-location recall from active learning and to the exploration strategy. Collectively, these findings suggest that age-related memory problems result partly from impaired strategies during learning, potentially due to reduced hippocampal-prefrontal co-engagement.

Lysozyme pattern formation in evaporating droplets

NASA Astrophysics Data System (ADS)

Gorr, Heather Meloy

Liquid droplets containing suspended particles deposited on a solid, flat surface generally form ring-like structures due to the redistribution of solute during evaporation (the "coffee ring effect"). The forms of the deposited patterns depend on complex interactions between solute(s), solvent, and substrate in a rapidly changing, far from equilibrium system. Solute self-organization during evaporation of colloidal sessile droplets has attracted the attention of researchers over the past few decades due to a variety of technological applications. Recently, pattern formation during evaporation of various biofluids has been studied due to potential applications in medical screening and diagnosis. Due to the complexity of 'real' biological fluids and other multicomponent systems, a comprehensive understanding of pattern formation during droplet evaporation of these fluids is lacking. In this PhD dissertation, the morphology of the patterns remaining after evaporation of droplets of a simplified model biological fluid (aqueous lysozyme solutions + NaCl) are examined by atomic force microscopy (AFM) and optical microscopy. Lysozyme is a globular protein found in high concentration, for example, in human tears and saliva. The drop diameters, D, studied range from the micro- to the macro- scale (1 microm -- 2 mm). In this work, the effect of evaporation conditions, solution chemistry, and heat transfer within the droplet on pattern formation is examined. In micro-scale deposits of aqueous lysozyme solutions (1 microm < D < 50 microm), the protein motion and the resulting dried residue morphology are highly influenced by the decreased evaporation time of the drop. The effect of electrolytes on pattern formation is also investigated by adding varying concentrations NaCl to the lysozyme solutions. Finally, a novel pattern recognition program is described and implemented which classifies deposit images by their solution chemistries. The results presented in this PhD dissertation provide insight into the evaporative behavior and pattern formation in droplets of simplified model biological fluids (aqueous lysozyme + NaCl). The patterns that form depend sensitively on the evaporation conditions, characteristic time and length scales, and the physiochemical properties of the solutions. The patterns are unique, dependent on solution chemistry, and may therefore act as a "fingerprint" in identifying fluid properties.

Novel Highly Parallel and Systolic Architectures Using Quantum Dot-Based Hardware

NASA Technical Reports Server (NTRS)

Fijany, Amir; Toomarian, Benny N.; Spotnitz, Matthew

1997-01-01

VLSI technology has made possible the integration of massive number of components (processors, memory, etc.) into a single chip. In VLSI design, memory and processing power are relatively cheap and the main emphasis of the design is on reducing the overall interconnection complexity since data routing costs dominate the power, time, and area required to implement a computation. Communication is costly because wires occupy the most space on a circuit and it can also degrade clock time. In fact, much of the complexity (and hence the cost) of VLSI design results from minimization of data routing. The main difficulty in VLSI routing is due to the fact that crossing of the lines carrying data, instruction, control, etc. is not possible in a plane. Thus, in order to meet this constraint, the VLSI design aims at keeping the architecture highly regular with local and short interconnection. As a result, while the high level of integration has opened the way for massively parallel computation, practical and full exploitation of such a capability in many applications of interest has been hindered by the constraints on interconnection pattern. More precisely. the use of only localized communication significantly simplifies the design of interconnection architecture but at the expense of somewhat restricted class of applications. For example, there are currently commercially available products integrating; hundreds of simple processor elements within a single chip. However, the lack of adequate interconnection pattern among these processing elements make them inefficient for exploiting a large degree of parallelism in many applications.

Pulsating Heat pipe Only for Space (PHOS): results of the REXUS 18 sounding rocket campaign

NASA Astrophysics Data System (ADS)

Creatini, F.; Guidi, G. M.; Belfi, F.; Cicero, G.; Fioriti, D.; Di Prizio, D.; Piacquadio, S.; Becatti, G.; Orlandini, G.; Frigerio, A.; Fontanesi, S.; Nannipieri, P.; Rognini, M.; Morganti, N.; Filippeschi, S.; Di Marco, P.; Fanucci, L.; Baronti, F.; Mameli, M.; Manzoni, M.; Marengo, M.

2015-11-01

Two Closed Loop Pulsating Heat Pipes (CLPHPs) are tested on board REXUS 18 sounding rocket in order to obtain data over a relatively long microgravity period (approximately 90 s). The CLPHPs are partially filled with FC-72 and have, respectively, an inner tube diameter larger (3 mm) and slightly smaller (1.6 mm) than the critical diameter evaluated in static Earth gravity conditions. On ground, the small diameter CLPHP effectively works as a Pulsating Heat Pipe (PHP): the characteristic slug and plug flow pattern forms inside the tube and the heat exchange is triggered by thermally driven self-sustained oscillations of the working fluid. On the other hand, the large diameter CLPHP works as a two- phase thermosyphon in vertical position and doesn't work in horizontal position: in this particular condition, the working fluid stratifies within the device as the surface tension force is no longer able to balance buoyancy. Then, the idea to test the CLPHPs in reduced gravity conditions: as the gravity reduces the buoyancy forces becomes less intense and it is possible to recreate the typical PHP flow pattern also for larger inner tube diameters. This allows to increase the heat transfer rate and, consequently, to decrease the overall thermal resistance. Even though it was not possible to experience low gravity conditions due to a failure in the yoyo de-spin system, the thermal response to the peculiar acceleration field (hyper-gravity) experienced on board are thoroughly described.

Are synesthetes exceptional beyond their synesthetic associations? A systematic comparison of creativity, personality, cognition, and mental imagery in synesthetes and controls.

PubMed

Chun, Charlotte A; Hupé, Jean-Michel

2016-08-01

Synesthesia has historically been linked with enhanced creativity, but this had never been demonstrated in a systematically recruited sample. The current study offers a broad examination of creativity, personality, cognition, and mental imagery in a small sample of systematically recruited synesthetes and controls (n = 65). Synesthetes scored higher on some measures of creativity, personality traits of absorption and openness, and cognitive abilities of verbal comprehension and mental imagery. The differences were smaller than those reported in the literature, indicating that previous studies may have overestimated group differences, perhaps due to biased recruitment procedures. Nonetheless, most of our results replicated literature findings, yielding two possibilities: (1) our study was influenced by similar biases, or (2) differences between synesthetes and controls, though modest, are robust across recruitment methods. The covariance among our measures warrants interpretation of these differences as a pattern of associations with synesthesia, leaving open the possibility that this pattern could be explained by differences on a single measured trait, or even a hidden, untested trait. More generally, this study highlights the difficulty of comparing groups of people in psychology, not to mention neuropsychology and neuroimaging studies. The requirements discussed here - systematic recruitment procedures, large battery of tests, and large cohorts - are best fulfilled through collaborative efforts and cumulative science. © 2015 The Authors. British Journal of Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

Lateral expansion and carbon exchange of a boreal peatland in Finland resulting in 7000 years of positive radiative forcing

NASA Astrophysics Data System (ADS)

Mathijssen, Paul J. H.; Kähkölä, Noora; Tuovinen, Juha-Pekka; Lohila, Annalea; Minkkinen, Kari; Laurila, Tuomas; Väliranta, Minna

2017-03-01

Data on past peatland growth patterns, vegetation development, and carbon (C) dynamics during the various Holocene climate phases may help us to understand possible future climate-peatland feedback mechanisms. In this study, we analyzed and radiocarbon dated several peat cores from Kalevansuo, a drained bog in southern Finland. We investigated peatland succession and C dynamics throughout the Holocene. These data were used to reconstruct the long-term atmospheric radiative forcing, i.e., climate impact of the peatland since initiation. Kalevansuo peat records revealed a general development from fen to bog, typical for the southern boreal zone, but the timing of ombrotrophication varied in different parts of the peatland. Peat accumulation patterns and lateral expansion through paludification were influenced by fires and climate conditions. Long-term C accumulation rates were overall lower than the average values found from literature. We suggest the low accumulation rates are due to repeated burning of the peat surface. Drainage for forestry resulted in a nearly complete replacement of typical bog mosses by forest species within 40 years after drainage. The radiative forcing reconstruction suggested positive values (warming) for the first 7000 years following initiation. The change from positive to negative forcing was triggered by an expansion of bog vegetation cover and later by drainage. The strong relationship between peatland area and peat type with radiative forcing suggests a possible feedback for future changing climate, as high-latitude peatlands may experience prominent regime shifts, such as fen to bog transitions.

A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.

PubMed

Takanari, Hiroki; Miwa, Keiko; Fu, XianMing; Nakai, Junichi; Ito, Akira; Ino, Kousuke; Honda, Hiroyuki; Tonomura, Wataru; Konishi, Satoshi; Opthof, Tobias; van der Heyden, Marcel Ag; Kodama, Itsuo; Lee, Jong-Kook

2016-10-01

Skeletal myoblast (SkMB) transplantation has been conducted as a therapeutic strategy for severe heart failure. However, arrhythmogenicity following transplantation remains unsolved. We developed an in vitro model of myoblast transplantation with "patterned" or "randomly-mixed" co-culture of SkMBs and cardiomyocytes enabling subsequent electrophysiological, and arrhythmogenic evaluation. SkMBs were magnetically labeled with magnetite nanoparticles and co-cultured with neonatal rat ventricular myocytes (NRVMs) on multi-electrode arrays. SkMBs were patterned by a magnet beneath the arrays. Excitation synchronicity was evaluated by Ca(2+) imaging using a gene-encoded Ca(2+) indicator, G-CaMP2. In the monoculture of NRVMs (control), conduction was well-organized. In the randomly-mixed co-culture of NRVMs and SkMBs (random group), there was inhomogeneous conduction from multiple origins. In the "patterned" co-culture where an en bloc SKMB-layer was inserted into the NRVM-layer, excitation homogenously propagated although conduction was distorted by the SkMB-area. The 4-mm distance conduction time (CT) in the random group was significantly longer (197 ± 126 ms) than in control (17 ± 3 ms). In the patterned group, CT through NRVM-area did not change (25 ± 3 ms), although CT through the SkMB-area was significantly longer (132 ± 77 ms). The intervals between spontaneous excitation varied beat-to-beat in the random group, while regular beating was recorded in the control and patterned groups. Synchronized Ca(2+) transients of NRVMs were observed in the patterned group, whereas those in the random group were asynchronous. Patterned alignment of SkMBs is feasible with magnetic nanoparticles. Using the novel in vitro model mimicking cell transplantation, it may become possible to predict arrhythmogenicity due to heterogenous cell transplantation. J. Cell. Physiol. 231: 2249-2256, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

A system for simulating aerial or orbital TV observations of geographic patterns

NASA Technical Reports Server (NTRS)

Latham, J. P.

1972-01-01

A system which simulates observation of the earth surface by aerial or orbiting television devices has been developed. By projecting color slides of photographs taken by aircraft and orbiting sensors upon a rear screen system, and altering scale of projected image, screen position, or TV camera position, it is possible to simulate alternatives of altitude, or optical systems. By altering scan line patterns in COHU 3200 series camera from 525 to 945 scan lines, it is possible to study implications of scan line resolution upon the detection and analysis of geographic patterns observed by orbiting TV systems.

Sleep Patterns as Predictors for Disability Pension Due to Low Back Diagnoses: A 23-Year Longitudinal Study of Finnish Twins

PubMed Central

Ropponen, Annina; Silventoinen, Karri; Hublin, Christer; Svedberg, Pia; Koskenvuo, Markku; Kaprio, Jaakko

2013-01-01

Study Objectives: Impaired sleep patterns are known to be associated with many chronic conditions and ultimately they may lead to permanent work incapacity. Less is known about the associations between sleep patterns and cause-specific disability pensions, such as low back diagnoses, or whether familial factors (genetics and family environment) can affect the associations. The objective of this study was to investigate sleep patterns as predictors of disability pension due to low back diagnoses with a 23-year follow-up. Design and Setting: A prospective cohort study with comprehensive mailed questionnaires about sleep patterns, e.g., quality and length of sleep in 1975 and 1981. Follow-up from the national disability pension register data until 2004. Interventions: Not applicable. Participants: There were 18,979 individuals (7,722 complete twin pairs) born before 1958. Measurements and Results: Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (95% CI). Disability pension due to low back diagnoses had been granted to 467 individuals during the follow-up. Sleeping moderately well (HR 1.25; 95% CI 1.02, 1.53), or fairly poorly/poorly (HR 2.05; 95% CI 1.53, 2.73) at baseline predicted a significantly higher risk for disability pension. Stable patterns of sleeping either fairly well (HR 1.29; 95% CI 1.01, 1.64), or stably fairly poorly/poorly (HR 2.29; 95% CI 1.49, 3.52) between 1975 and 1981 were associated with a higher risk as compared to a stable pattern of sleeping well. Furthermore, a decrease in quality of sleep from 1975 to 1981 was associated (HR 1.34; 95% CI 1.03, 1.76) with an increased risk of disability pension. Conclusions: Sleep quality and changes in sleep quality appear to be early predictors for disability pension due to low back diagnoses independently from other confounding factors. Citation: Ropponen A; Silventoinen K; Hublin C; Svedberg P; Koskenvuo M; Kaprio J. Sleep patterns as predictors for disability pension due to low back diagnoses: a 23-year longitudinal study of Finnish twins. SLEEP 2013;36(6):891-897. PMID:23729932

Memory repression: brain mechanisms underlying dissociative amnesia.

PubMed

Kikuchi, Hirokazu; Fujii, Toshikatsu; Abe, Nobuhito; Suzuki, Maki; Takagi, Masahito; Mugikura, Shunji; Takahashi, Shoki; Mori, Etsuro

2010-03-01

Dissociative amnesia usually follows a stressful event and cannot be attributable to explicit brain damage. It is thought to reflect a reversible deficit in memory retrieval probably due to memory repression. However, the neural mechanisms underlying this condition are not clear. We used fMRI to investigate neural activity associated with memory retrieval in two patients with dissociative amnesia. For each patient, three categories of face photographs and three categories of people's names corresponding to the photographs were prepared: those of "recognizable" high school friends who were acquainted with and recognizable to the patients, those of "unrecognizable" colleagues who were actually acquainted with but unrecognizable to the patients due to their memory impairments, and "control" distracters who were unacquainted with the patients. During fMRI, the patients were visually presented with these stimuli and asked to indicate whether they were personally acquainted with them. In the comparison of the unrecognizable condition with the recognizable condition, we found increased activity in the pFC and decreased activity in the hippocampus in both patients. After treatment for retrograde amnesia, the altered pattern of brain activation disappeared in one patient whose retrograde memories were recovered, whereas it remained unchanged in the other patient whose retrograde memories were not recovered. Our findings provide direct evidence that memory repression in dissociative amnesia is associated with an altered pattern of neural activity, and they suggest the possibility that the pFC has an important role in inhibiting the activity of the hippocampus in memory repression.

Urinary tract infections: a retrospective, descriptive study of causative organisms and antimicrobial pattern of samples received for culture, from a tertiary care setting

PubMed Central

Kalal, Bhuvanesh Sukhlal; Nagaraj, Savitha

2016-01-01

Introduction Urinary tract infections (UTI) are common infections encountered by physicians either on an outpatient or inpatient basis. These infections have taken center stage due to increasing resistance being reported for commonly used antibiotics. Understanding the distribution and antibiotic susceptibility patterns of uropathogens would facilitate appropriate therapy. Methods A retrospective analysis of the culture isolates obtained from urine samples received at the Department of Microbiology, St. John’s Medical College Hospital, Bengaluru India, was performed between January 2012 and May 2012. Results Of the 5592 urine specimens received, 28.2% showed significant growth. A total of 1673 identified pathogens were used in the analysis. Escherichia coli (54.6%) was the most common Gram-negative bacillus, followed by Klebsiella species (9.7%) and Pseudomonas species (7.5%). The most common Gram-positive coccus was Enterococcus (8.8%). Most of the Gram-negative isolates were resistant to ampicillin (79.3%) and cephalosporins (60%). Resistance to cephalosporins and fluoroquinolones was higher in isolates from inpatients. Other than Klebsiella spp., all other Enterobacteriaceae were susceptible to carbapenems (93%) and aminoglycosides (85%), whilst fluoroquinolones were effective for all Gram-positive bacteria. Conclusion Due to a high level of antimicrobial resistance amongst the pathogens causing UTI in India, it is cautious to advise or modify therapy, as far as possible, after culture and sensitivity testing have been performed. Regional surveillance programs are warranted for the development of national UTI guidelines. PMID:28053916

Urinary tract infections: a retrospective, descriptive study of causative organisms and antimicrobial pattern of samples received for culture, from a tertiary care setting.

PubMed

Kalal, Bhuvanesh Sukhlal; Nagaraj, Savitha

2016-12-01

Urinary tract infections (UTI) are common infections encountered by physicians either on an outpatient or inpatient basis. These infections have taken center stage due to increasing resistance being reported for commonly used antibiotics. Understanding the distribution and antibiotic susceptibility patterns of uropathogens would facilitate appropriate therapy. A retrospective analysis of the culture isolates obtained from urine samples received at the Department of Microbiology, St. John's Medical College Hospital, Bengaluru India, was performed between January 2012 and May 2012. Of the 5592 urine specimens received, 28.2% showed significant growth. A total of 1673 identified pathogens were used in the analysis. Escherichia coli (54.6%) was the most common Gram-negative bacillus, followed by Klebsiella species (9.7%) and Pseudomonas species (7.5%). The most common Gram-positive coccus was Enterococcus (8.8%). Most of the Gram-negative isolates were resistant to ampicillin (79.3%) and cephalosporins (60%). Resistance to cephalosporins and fluoroquinolones was higher in isolates from inpatients. Other than Klebsiella spp., all other Enterobacteriaceae were susceptible to carbapenems (93%) and aminoglycosides (85%), whilst fluoroquinolones were effective for all Gram-positive bacteria. Due to a high level of antimicrobial resistance amongst the pathogens causing UTI in India, it is cautious to advise or modify therapy, as far as possible, after culture and sensitivity testing have been performed. Regional surveillance programs are warranted for the development of national UTI guidelines.

Tandem Mass Spectrometry of Modified and Platinated Oligoribonucleotides

NASA Astrophysics Data System (ADS)

Nyakas, Adrien; Stucki, Silvan R.; Schürch, Stefan

2011-05-01

Therapeutic approaches for treatment of various diseases aim at the interruption of transcription or translation. Modified oligonucleotides, such as 2'- O-methyl- and methylphosphonate-derivatives, exhibit high resistance against cellular nucleases, thus rendering application for, e.g., antigene or antisense purposes possible. Other approaches are based on administration of cross-linking agents, such as cis-diamminedichloroplatinum(II) (cisplatin, DDP), which is still the most widely used anticancer drug worldwide. Due to the formation of 1,2-intrastrand cross links at adjacent guanines, replication of the double-strand is disturbed, thus resulting in significant cytotoxicity. Evidence for the gas-phase dissociation mechanism of platinated RNA is given, based on nano-electrospray ionization high-resolution multistage tandem mass spectrometry (MS n ). Confirmation was found by investigating the fragmentation pattern of platinated and unplatinated 2'-methoxy oligoribonucleotide hexamers and their corresponding methylphosphonate derivatives. Platinated 2'-methoxy oligoribonucleotides exhibit a similar gas-phase dissociation behavior as the corresponding DNA and RNA sequences, with the 3'-C-O bond adjacent to the vicinal guanines being cleaved preferentially, leading to wx-ion formation. By examination of the corresponding platinated methylphosphonate derivatives of the 2'-methoxy oligoribonucleotides, the key role of the negatively charged phosphate oxygen atoms in direct proximity to the guanines was proven. The significant alteration of fragmentation due to platination is demonstrated by comparison of the fragment ion patterns of unplatinated and platinated 2'- O-methyl- and 2'- O-methyl methylphosphonate oligoribonucleotides, and the results obtained by H/D exchange experiments.

Defect inspection of periodic patterns with low-order distortions

NASA Astrophysics Data System (ADS)

Khalaj, Babak H.; Aghajan, Hamid K.; Paulraj, Arogyaswami; Kailath, Thomas

1994-03-01

A self-reliance technique is developed for detecting defects in repeated pattern wafers and masks with low-order distortions. If the patterns are located on a perfect rectangular grid, it is possible to estimate the period of repeated patterns in both directions, and then produce a defect-free reference image for making comparison with the actual image. But in some applications, the repeated patterns are somehow shifted from their desired position on a rectangular grid, and the aforementioned algorithm cannot be directly applied. In these situations, to produce a defect-free reference image and locate the defected cells, it is necessary to estimate the amount of misalignment of each cell beforehand. The proposed technique first estimates the misalignment of repeated patterns in each row and column. After estimating the location of all cells in the image, a defect-free reference image is generated by averaging over all the cells and is compared with the input image to localize the possible defects.

Core muscle recruitment pattern during voluntary heel raises is different between patients with patellofemoral pain and healthy individuals.

PubMed

Biabanimoghadam, Mana; Motealleh, Alireza; Cowan, Sallie Melissa

2016-06-01

Recent studies suggest that the inconsistent outcomes of patellofemoral pain (PFP) treatment may result from the unclear understanding of changes in the structures remote from the knee joint. Due to the crucial influence of core stability on the knee function, this study aimed to evaluate the recruitment pattern of core muscles in individuals with and without PFP. Sixty women aged 18 to 40years, including 30 subjects diagnosed with PFP and 30 healthy controls rose on to their toes as quickly and strongly as possible in response to a sound alarm in standing position. Electromyographic onsets of the transversus abdominis (TrA)/internal oblique (IO), erector spinae (ES), and gluteus medius (GM) muscles were expressed relative to the electromyographic onset of the prime mover (i.e. soleus). Independent t-tests were performed to compare the onsets of each muscle between the groups. The nonparametric Friedman test and the post-hoc of Wilcoxon signed-rank test were used to describe the muscle activation pattern within the groups. The results revealed different recruitment patterns of the core muscles between the groups. In the healthy group the GM and TrA/IO contracted, almost simultaneously, in anticipation of the prime mover contraction (sol). However, in PFP subjects a significant delay in the contraction of TrA/IO changed the pattern of muscle activation. The findings demonstrate that muscular stabilization of spine is altered in the presence of PFP and suggest that treatment techniques aimed at improving core stability could be appropriate in the management of PFP. Copyright © 2016 Elsevier B.V. All rights reserved.

Patterns of multiple health risk–behaviours in university students and their association with mental health: application of latent class analysis

PubMed Central

Kwan, M. Y.; Arbour-Nicitopoulos, K. P.; Duku, E.; Faulkner, G.

2016-01-01

Abstract Introduction: University and college campuses may be the last setting where it is possible to comprehensively address the health of a large proportion of the young adult population. It is important that health promoters understand the collective challenges students are facing, and to better understand the broader lifestyle behavioural patterning evident during this life stage. The purpose of this study was to examine the clustering of modifiable health-risk behaviours and to explore the relationship between these identified clusters and mental health outcomes among a large Canadian university sample. Methods: Undergraduate students (n = 837; mean age = 21 years) from the University of Toronto completed the National College Health Assessment survey. The survey consists of approximately 300 items, including assessments of student health status, mental health and health-risk behaviours. Latent class analysis was used to identify patterning based on eight salient health-risk behaviours (marijuana use, other illicit drug use, risky sex, smoking, binge drinking, poor diet, physical inactivity, and insufficient sleep). Results: A three-class model based on student behavioural patterns emerged: “typical,” “high-risk” and “moderately healthy.” Results also found high-risk students reporting significantly higher levels of stress than typical students (χ2(1671) = 7.26, p < .01). Conclusion: Students with the highest likelihood of engaging in multiple health-risk behaviours reported poorer mental health, particularly as it relates to stress. Although these findings should be interpreted with caution due to the 28% response rate, they do suggest that interventions targeting specific student groups with similar patterning of multiple health-risk behaviours may be needed. PMID:27556920

Patterns of long-term care services use in a suburban municipality of Japan: a population-based study.

PubMed

Igarashi, Ayumi; Yamamoto-Mitani, Noriko; Yoshie, Satoru; Iijima, Katsuya

2017-05-01

Increasing service use under the long-term care insurance (LTCI) system in Japan requires a comprehensive understanding of how the services are actually used. This study aimed to identify patterns of LTCI service use and to examine the characteristics of the patterns. We analyzed data from a population of 4,339 older adults living in the community who were certified as "Needing Care" and were using at least one LTCI service in a suburban municipality of Japan. We identified six patterns of service use using cluster analysis based on the amount of fees for LTCI services and compared characteristics among the clusters. The clusters were: 1) light use of care services (n = 1,852); 2) day care-centered (n = 1,071); 3) day care with rehabilitation-centered (n = 616); 4) home help-centered (n = 365); 5) short-stay respite service-centered (n = 246); and 6) compound uses of visiting services (n = 189). "Home help-centered" and "short-stay respite service-centered" clusters used a large number of fees, whereas "compound uses of visiting services" clusters did not despite their severe conditions. The "day care-centered (with rehabilitation)" classification included few people who needed medical procedures, likely due to the lack of medical facilities in those agencies. The results show the impact of social and medical factors on LTCI service use, suggesting possible difficulties in the socialization of care. The clusters could be used as typical service use patterns, providing a framework for further studies, such as those evaluating the services' effects. Geriatr Gerontol Int 2017; 17: 753-759. © 2016 Japan Geriatrics Society.

Comparing dietary patterns of depressed patients versus healthy people in a case control protocol

PubMed Central

Khosravi, Maryam; Sotoudeh, Gity; Raisi, Firoozeh; Majdzadeh, Reza; Foroughifar, Tahereh

2014-01-01

Introduction Major depressive disorder is the leading cause of disability around the world. Because of the high rate of medication discontinuation by patients and the risk of recurrence, factors such as nutrition could be useful for the prevention or treatment of depression. The relationship between depression and dietary patterns has been reported in a few studies but with controversial results. Therefore, we have decided to study the possible effects of cultural, social, racial, geographic and environmental conditions on this relationship in an Iranian population. Methods and analysis In our case control protocol, 110 cases and 220 controls will be individually matched based on age, sex and area of residence. New cases of depression, based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), will be recruited from two psychiatric clinics in Tehran. Interviewers will then go to each patient's home and invite qualified individuals to participate in the study as controls. Food intakes of all participants will be obtained by semiquantitative food frequency questionnaires covering the past year; these will be transformed into actual food intake (g/day). Dietary patterns will be determined by the principal components method. Conditional logistic regression, as a multivariate analysis, will be used for assessing the relationship between dietary patterns and depression, taking into consideration the potential role of different variables. The results may help to identify differences in dietary patterns between depressed and healthy people. Ethics and dissemination The study protocol has been approved by ethics committee of Tehran University of Medical Sciences. At the beginning of the study, a written informed consent form will be signed and dated by subjects and investigators. The results will be published in due time. PMID:24525387

Kinematic dynamo action in square and hexagonal patterns.

PubMed

Favier, B; Proctor, M R E

2013-11-01

We consider kinematic dynamo action in rapidly rotating Boussinesq convection just above onset. The velocity is constrained to have either a square or a hexagonal pattern. For the square pattern, large-scale dynamo action is observed at onset, with most of the magnetic energy being contained in the horizontally averaged component. As the magnetic Reynolds number increases, small-scale dynamo action becomes possible, reducing the overall growth rate of the dynamo. For the hexagonal pattern, the breaking of symmetry between up and down flows results in an effective pumping velocity. For intermediate rotation rates, this additional effect can prevent the growth of any mean-field dynamo, so that only a small-scale dynamo is eventually possible at large enough magnetic Reynolds number. For very large rotation rates, this pumping term becomes negligible, and the dynamo properties of square and hexagonal patterns are qualitatively similar. These results hold for both perfectly conducting and infinite magnetic permeability boundary conditions.

Applying complex networks to evaluate precipitation patterns over South America

NASA Astrophysics Data System (ADS)

Ciemer, Catrin; Boers, Niklas; Barbosa, Henrique; Kurths, Jürgen; Rammig, Anja

2016-04-01

The climate of South America exhibits pronounced differences between the wet- and the dry-season, which are accompanied by specific synoptic events like changes in the location of the South American Low Level Jet (SALLJ) and the establishment of the South American Convergence Zone (SACZ). The onset of these events can be related to the presence of typical large-scale precipitation patterns over South America, as previous studies have shown[1,2]. The application of complex network methods to precipitation data recently received increased scientific attention for the special case of extreme events, as it is possible with such methods to analyze the spatiotemporal correlation structure as well as possible teleconnections of these events[3,4]. In these approaches the correlation between precipitation datasets is calculated by means of Event Synchronization which restricts their applicability to extreme precipitation events. In this work, we propose a method which is able to consider not only extreme precipitation but complete time series. A direct application of standard similarity measures in order to correlate precipitation time series is impossible due to their intricate statistical properties as the large amount of zeros. Therefore, we introduced and evaluated a suitable modification of Pearson's correlation coefficient to construct spatial correlation networks of precipitation. By analyzing the characteristics of spatial correlation networks constructed on the basis of this new measure, we are able to determine coherent areas of similar precipitation patterns, spot teleconnections of correlated areas, and detect central regions for precipitation correlation. By analyzing the change of the network over the year[5], we are also able to determine local and global changes in precipitation correlation patterns. Additionally, global network characteristics as the network connectivity yield indications for beginning and end of wet- and dry season. In order to identify large-scale synoptic events like the SACZ and SALLJ onset, detecting the changes of correlation over time between certain regions is of significant relevance. [1] Nieto-Ferreira et al. Quarterly Journal of the Royal Meteorological Society (2011) [2] Vera et al. Bulletin of the American Meteorological Society (2006) [3] Quiroga et al. Physical review E (2002) [4] Boers et al. nature communications (2014) [5] Radebach et al. Physical review E (2013)

CT-Pathologic Correlation of Major Types of Pulmonary Fibrosis: Insights for Revisions to Current Guidelines.

PubMed

Chung, Jonathan H; Oldham, Justin M; Montner, Steven M; Vij, Rekha; Adegunsoye, Ayodeji; Husain, Aliya N; Noth, Imre; Lynch, David A; Strek, Mary E

2018-05-01

The purpose of this study was to assess the diagnostic significance of CT patterns that cannot be classified according to current idiopathic pulmonary fibrosis (IPF) guidelines and of specific findings of the inconsistent with usual interstitial pneumonitis (UIP) pattern. Subjects with a multidisciplinary diagnosis of interstitial lung disease who had undergone surgical lung biopsy and chest CT within 1 year of each other were included in the study. The predominant distribution and pattern of disease were scored. Cases were classified as UIP, possible UIP, or inconsistent with UIP at chest CT according to 2011 IPF guidelines. Cases that could not be confidently categorized with current guidelines were annotated as indeterminate. UIP, possible UIP, and inconsistent with UIP CT patterns were associated with pathologic UIP in 89.6%, 81.6%, and 60.0% of subjects. An indeterminate CT pattern (7.7% [20/259]) was associated with a UIP pathologic diagnosis in 55.0% of cases. This finding was not statistically different from the findings in the group with the inconsistent with UIP CT pattern (p = 0.677) but was different from the findings in the UIP (p < 0.001) and possible UIP (p = 0.031) groups. In regard to specific findings of the inconsistent with UIP CT category, ground-glass opacity, air-trapping, consolidation, and axial distribution were associated with a non-UIP pathologic diagnosis; however, there was no significant association with zonal distribution. A substantial minority of cases cannot be confidently categorized according to current guidelines for IPF and differ diagnostically from the possible UIP and UIP CT categories. The term "inconsistent with UIP" is misleading and should be renamed.

Submicron Surface-Patterned Fibers and Textiles

DTIC Science & Technology

2016-11-04

These authors contributed equally Keywords: grating, fiber, polymer , patterning, textile Distribution A: approved for public release...requirements. Second, textile materials are primarily polymer -based, while most surface-patterning techniques have been developed for silicon...Alternative substrates, especially flexible polymers , remain challenging to pattern [25,26] due to the highly specific surface chemistry of different

Tidal-Induced Ocean Dynamics as Cause of Enceladus' Tiger Stripe Pattern

NASA Astrophysics Data System (ADS)

Vermeersen, B. L.; Maas, L. R.; van Oers, S.; Rabitti, A.; Jara-Orue, H.

2013-12-01

One of the most peculiar features on Saturn moon Enceladus is its so-called tiger stripe pattern at the geologically active South Polar Terrain (SPT), as first observed in detail by the Cassini spacecraft early 2005. It is generally assumed that the four almost parallel surface lines that constitute this pattern are faults in the icy surface overlying a confined salty water reservoir. Indeed, later Cassini observations have shown that salty water jets originate from the tiger stripes [e.g., Hansen et al., Science, 311, 1422-1425, 2006; Postberg et al., Nature, 474, 620-622, 2011]. The periodic activity of the tiger stripe faults shows a strong correlation with tidal forcing. Jets emanating from specific fault lines seem to be triggered at those places of the faults where tidal-induced stresses are largest immediately following closest orbital approach with Saturn [e.g., Hurford et al., Nature, 447, 292-294, 2007]. Thus jet activity seems to be directly induced by tidal forcing. However, this does not explain the characteristic regular pattern of the stripes themselves. Here we explore the possibility that this pattern is formed and maintained by induced, tidally and rotationally driven, fluid motions in the ocean underneath the icy surface of the tiger-stripe region. The remarkable spatial regularity of Enceladus' SPT fault lines is reminiscent of that observed at the surface of confined density-stratified fluids by the action of induced internal gravity waves. Theoretical analysis, numerical simulations and laboratory water tank experiments all indicate that wave attractors - particular limit orbits to which waves are focused in a fluid basin - naturally emerge in gravitationally (radial salt concentration or temperature differences) or rotationally stratified confined fluids as a function of forcing periodicity and fluid basin geometry [Maas et al., Nature, 338, 557-561, 1997]. We have found that ocean dynamical wave attractors induced by tidal-effective forcing of Enceladus' SPT salty water basin can reproduce the general characteristics of the observed tiger stripe pattern and even offer the possibility of constraining the 3D-form of the salty water basin underlying Enceladus' SPT. Vertical cross section of one of the water tank experiments. The tank is uniformly stratified with salty water and harmonically shaken. Wave attractors impinge at the surface of the tank at A, B and C, which are places where an overlying plate experiences enhanced stress levels. Distances A-B and B-C are not the same due to a sloping floor of the fluid tank. The length of the tank is about 1.5 m. Numbers at the bottom indicate mm.

The potential vulnerability of the Namib and Nama Aquifers due to low recharge levels in the area surrounding the Naukluft Mountains, SW Namibia

NASA Astrophysics Data System (ADS)

Kambinda, Winnie N.; Mapani, Benjamin

2017-12-01

The Naukluft Mountains in the Namib Desert are a high rainfall-high discharge area. It sees increased stream-, spring-flow as well as waterfalls during the rainy season. The mountains are a major resource for additional recharge to the Namib and Nama aquifers that are adjacent to the mountains. This paper aimed to highlight the potential vulnerability of the aquifers that surround the Naukluft Mountain area; if the strategic importance of the Naukluft Karst Aquifer (NKA) for bulk water supply becomes necessary. Chloride Mass Balance Method (CMBM) was applied to estimate rainfall available for recharge as well as actual recharge thereof. This was applied using chloride concentration in precipitation, borehole and spring samples collected from the study area. Groundwater flow patterns were mapped from hydraulic head values. A 2D digital elevation model was developed using Arc-GIS. Results highlighted the influence of the NKA on regional groundwater flow. This paper found that groundwater flow was controlled by structural dip and elevation. Groundwater was observed to flow predominantly from the NKA to the south west towards the Namib Aquifer in two distinct flow patterns that separate at the center of the NKA. A distinct groundwater divide was defined between the two flow patterns. A minor flow pattern from the northern parts of the NKA to the north east towards the Nama Aquifer was validated. Due to the substantial water losses, the NKA is not a typical karst aquifer. While the project area receives an average rainfall of 170.36 mm/a, it was estimated that 1-14.24% (maximum 24.43 mm/a) rainfall was available for recharge to the NKA. Actual recharge to the NKA was estimated to be less than 1-18.21% (maximum 4.45 mm/a) reflecting the vast losses incurred by the NKA via discharge. This paper concluded that groundwater resources of the NKA were potentially finite. The possibility of developing the aquifer for bulk water supply would therefore drastically lower recharge to surrounding aquifers that sustain local populations because all received rainfall will be utilized to maximise recharge to the NKA instead of surrounding aquifers.

Diversity pattern in Sesamum mutants selected for a semi-arid cropping system.

PubMed

Murty, B R; Oropeza, F

1989-02-01

Due to the complex requirements of moisture stress, substantial genetic diversity with a wide array of character combinations and effective simultaneous selection for several variables is necessary for improving the productivity and adaptation of a component crop in order for it to fit into a cropping system under semi-arid tropical conditions. Sesamum indicum L. is grown in Venezuela after rice/sorghum/or maize under such conditions. A mutation breeding program was undertaken using six locally adapted varieties to develop genotypes suitable for the above system. The diversity pattern for nine variables was assessed by multivariate analysis in 301 M4 progenies. Analysis of the characteristic roots and principal components in three methods of selection, i.e., M2 bulks (A), individual plant selection throughout (B), and selection in M3 for single variable (C), revealed differences in the pattern of variation between varieties, selection methods, and varieties x methods interactions. Method B was superior to the others and gave 17 of the 21 best M5 progenies. 'Piritu' and 'CF' varieties yielded the most productive progenies in M5 and M6. Diversity was large and selection was effective for such developmental traits as earliness and synchrony, combined with multiple disease resistance, which could be related to their importance by multivariate analyses. Considerable differences in the variety of character combinations among the high yielding. M5 progenies of 'CF' and 'Piritu' suggested possible further yield improvement. The superior response of 'Piritu' and 'CF' over other varieties in yield and adaptation was due to major changes in plant type and character associations. Multilocation testing of M5 generations revealed that the mutant progenies had a 40%-100% yield superiority over the parents; this was combined with earliness, synchrony, and multiple disease resistance, and was confirmed in the M6 generation grown on a commercial scale. This study showed that multivariate analysis is an effective tool for assessing diversity patterns, choice of appropriate variety, and selection methodology in order to make rapid progress in meeting the complex requirements of semi-arid cropping systems.

Round-patterned ZnO nanostructure coated with siloxane-based polymer for nerve agent detection

NASA Astrophysics Data System (ADS)

Choi, Hyun Ji; Lee, Ji Won; Jeong, Dong-Cheol; Ha, Seonggyun; Song, Changsik; Boo, Jin-Hyo

2018-01-01

The alignment of zinc oxide (ZnO) nanostructures is expected to improve device sensitivities due to large surface areas which can be utilized to capture significant quantities of gas particles. In this study, we investigated patterned ZnO nanorods modified with polystyrene monolayers synthesized directly onto a quartz crystal microbalance (QCM) cell to increase the coating surface area of the sensing material. Also, we designed and synthesized a siloxane-based polymer (S1 polymer) as a sensing material. The patterned ZnO nanorods coated with S1 polymers were fabricated and used for the detection of dimethyl methylphosphonate (DMMP). The resonance frequency of QCM was shifted due to the adsorption and desorption of a compound at the surface of the modified electrodes. We have synthesized an S1 polymer that exhibited high sensitivity to DMMP. The patterned ZnO nanorods coated with the polymer also exhibited improved sensitivity due to an enhanced surface area capable of adsorbing more DMMP vapor.

Porphyromonas endodontalis: prevalence and distribution of restriction enzyme patterns in families.

PubMed

Petit, M D; van Winkelhoff, A J; van Steenbergen, T J; de Graaff, J

1993-08-01

In this study we determined the prevalence and distribution of Porphyromonas endodontalis in 26 families consisting of 107 subjects. P. endodontalis was present in 24% of the investigated subjects and was recovered most often from the dorsum of the tongue (50%). Isolation was also possible from the tonsils, the buccal mucosa, the saliva and the periodontal pocket. The usefulness of restriction endonuclease analysis as a typing method for this particular species was investigated by typing 19 isolates from unrelated individuals. All these isolates had unique restriction endonuclease patterns. The observed heterogeneity indicates that restriction endonuclease analysis is a sensitive measure of genetic dissimilarity between P. endodontalis isolates and is able to characterize individual isolates. Application of restriction endonuclease analysis to the obtained clinical isolates in this study shows the possibility of the presence of multiple clonal types within one subject. The DNA patterns of all P. endodontalis isolates from unrelated individuals were found to be distinct. In 3 families the DNA patterns of isolates from the mother and her child were indistinguishable. These data indicate the possibility of intrafamilial transmission of P. endodontalis.

Shear wave splitting and shear wave splitting tomography of the southern Puna plateau

NASA Astrophysics Data System (ADS)

Calixto, Frank J.; Robinson, Danielle; Sandvol, Eric; Kay, Suzanne; Abt, David; Fischer, Karen; Heit, Ben; Yuan, Xiaohui; Comte, Diana; Alvarado, Patricia

2014-11-01

We have investigated the seismic anisotropy beneath the Central Andean southern Puna plateau by applying shear wave splitting analysis and shear wave splitting tomography to local S waves and teleseismic SKS, SKKS and PKS phases. Overall, a very complex pattern of fast directions throughout the southern Puna plateau region and a circular pattern of fast directions around the region of the giant Cerro Galan ignimbrite complex are observed. In general, teleseismic lag times are much greater than those for local events which are interpreted to reflect a significant amount of sub and inner slab anisotropy. The complex pattern observed from shear wave splitting analysis alone is the result of a complex 3-D anisotropic structure under the southern Puna plateau. Our application of shear wave splitting tomography provides a 3-D model of anisotropy in the southern Puna plateau that shows different patterns depending on the driving mechanism of upper-mantle flow and seismic anisotropy. The trench parallel a-axes in the continental lithosphere above the slab east of 68W may be related to deformation of the overriding continental lithosphere since it is under compressive stresses which are orthogonal to the trench. The more complex pattern below the Cerro Galan ignimbrite complex and above the slab is interpreted to reflect delamination of continental lithosphere and upwelling of hot asthenosphere. The a-axes beneath the Cerro Galan, Cerro Blanco and Carachi Pampa volcanic centres at 100 km depth show some weak evidence for vertically orientated fast directions, which could be due to vertical asthenospheric flow around a delaminated block. Additionally, our splitting tomographic model shows that there is a significant amount of seismic anisotropy beneath the slab. The subslab mantle west of 68W shows roughly trench parallel horizontal a-axes that are probably driven by slab roll back and the relatively small coupling between the Nazca slab and the underlying mantle. In contrast, the subslab region (i.e. depths greater than 200 km) east of 68W shows a circular pattern of a-axes centred on a region with small strength of anisotropy (Cerro Galan and its eastern edge) which suggest the dominant mechanism is a combination of slab roll back and flow driven by an overlying abnormally heated slab or possibly a slab gap. There seems to be some evidence for vertical flow below the slab at depths of 200-400 km driven by the abnormally heated slab or slab gap. This cannot be resolved by the tomographic inversion due to the lack of ray crossings in the subslab mantle.

College Students' Judgment of Others Based on Described Eating Pattern

ERIC Educational Resources Information Center

Pearson, Rebecca; Young, Michael

2008-01-01

Background: The literature available on attitudes toward eating patterns and people choosing various foods suggests the possible importance of "moral" judgments and desirable personality characteristics associated with the described eating patterns. Purpose: This study was designed to replicate and extend a 1993 study of college students'…

How Do They Grow?

ERIC Educational Resources Information Center

Chan, Helen Hsu

2015-01-01

Students' experiences with pattern blocks begin as early as preschool. At that time, they begin to develop an understanding of repetition by alternating the colored shapes to create AB, AAB, or ABC patterns. They experiment with area and symmetry by covering polygonal spaces using the fewest (or the greatest) number of pattern blocks possible or…

Genetic diversity and connectivity of the megamouth shark (Megachasma pelagios)

PubMed Central

Joung, Shoou Jeng; Yu, Chi-Ju; Hsu, Hua-Hsun; Tsai, Wen-Pei; Liu, Kwang Ming

2018-01-01

The megamouth shark (Megachasma pelagios) was described as a new species in 1983. Since then, only ca. 100 individuals have been observed or caught. Its horizontal migration, dispersal, and connectivity patterns are still unknown due to its rarity. Two genetic markers were used in this study to reveal its genetic diversity and connectivity pattern. This approach provides a proxy to indirectly measure gene flow between populations. Tissues from 27 megamouth sharks caught by drift nets off the Hualien coast (eastern Taiwan) were collected from 2013 to 2015. With two additional tissue samples from megamouths caught in Baja California, Mexico, and sequences obtained from GenBank, we were able to perform the first population genetic analyses of the megamouth shark. The mtDNA cox1 gene and a microsatellite (Loc 6) were sequenced and analyzed. Our results showed that there is no genetic structure in the megamouth shark, suggesting a possible panmictic population. Based on occurrence data, we also suggest that the Kuroshio region, including the Philippines, Taiwan, and Japan, may act as a passageway for megamouth sharks to reach their feeding grounds from April to August. Our results provide insights into the dispersal and connectivity of megamouth sharks. Future studies should focus on collecting more samples and conducting satellite tagging to better understand the global migration and connectivity pattern of the megamouth shark. PMID:29527411

Patterns and processes in the genetic differentiation of the Brachionus calyciflorus complex, a passively dispersing freshwater zooplankton.

PubMed

Xiang, Xian-ling; Xi, Yi-long; Wen, Xin-li; Zhang, Gen; Wang, Jin-xia; Hu, Ke

2011-05-01

Elucidating the evolutionary patterns and processes of extant species is an important objective of any research program that seeks to understand population divergence and, ultimately, speciation. The island-like nature and temporal fluctuation of limnetic habitats create opportunities for genetic differentiation in rotifers through space and time. To gain further understanding of spatio-temporal patterns of genetic differentiation in rotifers other than the well-studied Brachionus plicatilis complex in brackish water, a total of 318 nrDNA ITS sequences from the B. calyciflorus complex in freshwater were analysed using phylogenetic and phylogeographic methods. DNA taxonomy conducted by both the sequence divergence and the GMYC model suggested the occurrence of six potential cryptic species, supported also by reproductive isolation among the tested lineages. The significant genetic differentiation and non-significant correlation between geographic and genetic distances existed in the most abundant cryptic species, BcI-W and Bc-SW. The large proportion of genetic variability for cryptic species Bc-SW was due to differences between sampling localities within seasons, rather than between different seasons. Nested Clade Analysis suggested allopatric or past fragmentation, contiguous range expansion and long-distance colonization possibly coupled with subsequent fragmentation as the probable main forces shaping the present-day phylogeographic structure of the B. calyciflorus species complex. Copyright © 2011 Elsevier Inc. All rights reserved.

Environmental drivers of the distribution of nitrogen functional genes at a watershed scale.

PubMed

Tsiknia, Myrto; Paranychianakis, Nikolaos V; Varouchakis, Emmanouil A; Nikolaidis, Nikolaos P

2015-06-01

To date only few studies have dealt with the biogeography of microbial communities at large spatial scales, despite the importance of such information to understand and simulate ecosystem functioning. Herein, we describe the biogeographic patterns of microorganisms involved in nitrogen (N)-cycling (diazotrophs, ammonia oxidizers, denitrifiers) as well as the environmental factors shaping these patterns across the Koiliaris Critical Zone Observatory, a typical Mediterranean watershed. Our findings revealed that a proportion of variance ranging from 40 to 80% of functional genes abundance could be explained by the environmental variables monitored, with pH, soil texture, total organic carbon and potential nitrification rate being identified as the most important drivers. The spatial autocorrelation of N-functional genes ranged from 0.2 to 6.2 km and prediction maps, generated by cokriging, revealed distinct patterns of functional genes. The inclusion of functional genes in statistical modeling substantially improved the proportion of variance explained by the models, a result possibly due to the strong relationships that were identified among microbial groups. Significant relationships were set between functional groups, which were further mediated by land use (natural versus agricultural lands). These relationships, in combination with the environmental variables, allow us to provide insights regarding the ecological preferences of N-functional groups and among them the recently identified clade II of nitrous oxide reducers. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Effects of seasonality on drosophilids (Insecta, Diptera) in the northern part of the Atlantic Forest, Brazil.

PubMed

Coutinho-Silva, R D; Montes, M A; Oliveira, G F; de Carvalho-Neto, F G; Rohde, C; Garcia, A C L

2017-10-01

Seasonality is an important aspect associated with population dynamic and structure of tropical insect assemblages. This study evaluated the effects of seasonality on abundance, richness, diversity and composition of an insect group, drosophilids, including species native to the Neotropical region and exotic ones. Three preserved fragments of the northern Atlantic Forest were surveyed, where temperatures are above 20 °C throughout the year and rainfall regimes define two seasons (dry and rainy). As opposed to other studies about arthropods in tropical regions, we observed that abundance of drosophilids was significantly higher in the dry season, possibly due to biological aspects and the colonization strategy adopted by the exotic species in these environments. Contrarily to abundance, we did not observe a seasonal pattern for richness. As for other parts of the Atlantic Forest, the most representative Neotropical species (Drosophila willistoni, D. sturtevanti, D. paulistorum and D. prosaltans) were significantly more abundant in the rainy season. Among the most abundant exotic species, D. malerkotliana, Zaprionus indianus and Scaptodrosophila latifasciaeformis were more importantly represented the dry season, while D. simulans was more abundant in the rainy period. The seasonality patterns exhibited by the most abundant species were compared to findings published in other studies. Our results indicate that exotic species were significantly more abundant in the dry season, while native ones exhibited an opposite pattern.

Interrelationships between Amerindian tribes of lower Amazonia as manifest by HLA haplotype disequilibria.

PubMed

Black, F L

1984-11-01

HLA B-C haplotypes exhibit common disequilibria in populations drawn from four continents, indicating that they are subject to broadly active selective forces. However, the A-B and A-C associations we have examined show no consistent disequilibrium pattern, leaving open the possibility that these disequilibria are due to descent from common progenitors. By examining HLA haplotype distributions, I have explored the implications that would follow from the hypothesis that biological selection played no role in determining A-C disequilibria in 10 diverse tribes of the lower Amazon Basin. Certain haplotypes are in strong positive disequilibria across a broad geographic area, suggesting that members of diverse tribes descend from common ancestors. On the basis of the extent of diffusion of the components of these haplotypes, one can estimate that the progenitors lived less than 6,000 years ago. One widely encountered lineage entered the area within the last 1,200 years. When haplotype frequencies are used in genetic distance measurements, they give a pattern of relationships very similar to that obtained by conventional chord measurements based on several genetic markers; but more than that, when individual haplotype disequilibria in the several tribes are compared, multiple origins of a single tribe are discernible and relationships are revealed that correlate more closely to geographic and linguistic patterns than do the genetic distance measurements.

Decreased competitive interactions drive a reverse species richness latitudinal gradient in subarctic forests.

PubMed

Marshall, Katie E; Baltzer, Jennifer L

2015-02-01

The tendency for species richness to decrease toward the poles is one of the best-characterized patterns in biogeography. The mechanisms behind this pattern have received much attention, yet very few studies have investigated very high-latitude communities. Here, using data from 134 permanent sample plots from 60 degrees to 68 degrees N, we show that boreal forest plant communities in northwestern Canada increase in richness toward the poles, despite a strong increase in climatic harshness. We hypothesized three possible explanations for this pattern: (1) historical biogeography, (2) reduced competition for light at high latitudes (biotic interactions), and (3) changes in soil characteristics with latitude. We used multidimensional scaling to investigate the community composition at each site and found no clustering of communities by latitude, suggesting that historical biogeography was not constraining site diversity. We then investigated the mechanisms behind this gradient using both abiotic (climate and soil) and biotic (tree stand characteristics) variables in a multiple factor analysis. We found that the best predictor of species richness is an environmental gradient that describes an inverse relationship between temperature and tree-stand density, suggesting that reduced competition for light due to reduced tree growth at low temperatures at higher latitudes allows greater species richness. This study shows that low energy availability and climatic harshness may not be limiting species richness toward the poles, rather, abiotic effects act instead on the strength of biotic interactions.

Visualization of NO2 emission sources using temporal and spatial pattern analysis in Asia

NASA Astrophysics Data System (ADS)

Schütt, A. M. N.; Kuhlmann, G.; Zhu, Y.; Lipkowitsch, I.; Wenig, M.

2016-12-01

Nitrogen dioxide (NO2) is an indicator for population density and level of development, but the contributions of the different emission sources to the overall concentrations remains mostly unknown. In order to allocate fractions of OMI NO2 to emission types, we investigate several temporal cycles and regional patterns.Our analysis is based on daily maps of tropospheric NO2 vertical column densities (VCDs) from the Ozone Monitoring Instrument (OMI). The data set is mapped to a high resolution grid by a histopolation algorithm. This algorithm is based on a continuous parabolic spline, producing more realistic smooth distributions while reproducing the measured OMI values when integrating over ground pixel areas.In the resulting sequence of zoom in maps, we analyze weekly and annual cycles for cities, countryside and highways in China, Japan and Korea Republic and look for patterns and trends and compare the derived results to emission sources in Middle Europe and North America. Due to increased heating in winter compared to summer and more traffic during the week than on Sundays, we dissociate traffic, heating and power plants and visualized maps with different sources. We will also look into the influence of emission control measures during big events like the Olympic Games 2008 and the World Expo 2010 as a possibility to confirm our classification of NO2 emission sources.

Evolution of Hox-like genes in Cnidaria: Study of Hydra Hox repertoire reveals tailor-made Hox-code for Cnidarians.

PubMed

Reddy, Puli Chandramouli; Unni, Manu K; Gungi, Akhila; Agarwal, Pallavi; Galande, Sanjeev

2015-11-01

Hox and ParaHox genes play decisive roles in patterning the anterior-posterior body axis in Bilateria. Evolutionary origin of Hox genes and primary body axis predate the divergence of Bilateria and Cnidaria. However, function of Cnidarian Hox-like genes and their regulation in axis determination is obscure due to studies limited to a few representative model systems. Present investigation is conducted using Hydra, a Hydrozoan member of phylum Cnidaria, to gain insights into the roles of Cnidarian Hox-like genes in primary axis formation. Here, we report identification of six Hox-like genes from our in-house transcriptome data. Phylogenetic analysis of these genes shows bilaterian counterparts of Hox1, Gsx and Mox. Additionally, we report CnoxB_HVUL, CnoxC2_HVUL and CnoxC3_HVUL belonging to two Cnidarian specific groups. In situ hybridization analysis of Hydra homologues provided important clues about their possible roles in pattern formation of polyps and bud development. Specifically, Hox1_HVUL is regulated by Wnt signaling and plays critical role in head formation. Collating information about expression patterns of different Hox-like genes from previous reports and this study reveals no conformity within Cnidaria. Indicating that unlike in Bilateria, there is no consolidated Hox-code determining primary body axis in Cnidaria. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Interconnect patterns for printed organic thermoelectric devices with large fill factors

NASA Astrophysics Data System (ADS)

Gordiz, Kiarash; Menon, Akanksha K.; Yee, Shannon K.

2017-09-01

Organic materials can be printed into thermoelectric (TE) devices for low temperature energy harvesting applications. The output voltage of printed devices is often limited by (i) small temperature differences across the active materials attributed to small leg lengths and (ii) the lower Seebeck coefficient of organic materials compared to their inorganic counterparts. To increase the voltage, a large number of p- and n-type leg pairs is required for organic TEs; this, however, results in an increased interconnect resistance, which then limits the device output power. In this work, we discuss practical concepts to address this problem by positioning TE legs in a hexagonal closed-packed layout. This helps achieve higher fill factors (˜91%) than conventional inorganic devices (˜25%), which ultimately results in higher voltages and power densities due to lower interconnect resistances. In addition, wiring the legs following a Hilbert spacing-filling pattern allows for facile load matching to each application. This is made possible by leveraging the fractal nature of the Hilbert interconnect pattern, which results in identical sub-modules. Using the Hilbert design, sub-modules can better accommodate non-uniform temperature distributions because they naturally self-localize. These device design concepts open new avenues for roll-to-roll printing and custom TE module shapes, thereby enabling organic TE modules for self-powered sensors and wearable electronic applications.

Investigation on the impact of irregular fringe patterns of a single-fiber Mach-Zehnder interferometer on its sensing capabilities

NASA Astrophysics Data System (ADS)

Kumar, Naveen; Kumar, Ashish

2018-07-01

A novel single-mode single-fiber (SMSF) MZI formed by cascading of two non-adiabatic fiber tapers, with stable and repeatable spectrum, has been found to be useful in sensing applications in recent times. A multimode interference based novel simulation approach is proposed to predict the sensing characteristics of SMSF-MZI and is validated with experimental observation. The proposed method includes solving of simultaneous non-homogenous equations for determining the amplitudes of the interfering modes excited in the tapered section of the interferometer. The simulated fringe pattern and the experimental spectral response converge to some important comprehension reported for the first time. A linear shift in output spectral response, of SMSF-MZI, due to change in optical path length induced by temperature/strain etc., is likely to be characterized by three modes interference occurring in the interference region of the interferometer. Whereas if the spectral shift starts saturating at moderately higher temperature/strain, then the formation of interference fringes are possibly governed by two modes interference. Further, it was also explained that a SMSF-MZI with variable fringe widths in its spectral pattern exhibits higher sensitivity than that of the SMSF-MZI having wavelength spectrum with uniform free spectral range. These findings are useful in selecting and predicting the sensitivity of a given SMSF-MZI, based on its spectrum, for sensing applications.

Glomerular Activity Patterns Evoked by Natural Odor Objects in the Rat Olfactory Bulb Are Related to Patterns Evoked by Major Odorant Components

PubMed Central

Johnson, Brett A.; Ong, Joan; Leon, Michael

2014-01-01

To determine how responses evoked by natural odorant mixtures compare to responses evoked by individual odorant chemicals, we mapped 2-deoxyglucose uptake during exposures to vapors arising from a variety of odor objects that may be important to rodents in the wild. We studied 21 distinct natural odor stimuli ranging from possible food sources such as fruits, vegetables, and meats to environmental odor objects such as grass, herbs, and tree leaves. The natural odor objects evoked robust and surprisingly focal patterns of 2-deoxyglucose uptake involving clusters of neighboring glomeruli, thereby resembling patterns evoked by pure chemicals. Overall, the patterns were significantly related to patterns evoked by monomolecular odorant components that had been studied previously. Object patterns also were significantly related to the molecular features present in the mixture components. Despite these overall relationships, there were individual examples of object patterns that were simpler than might have been predicted given the multiplicity of components present in the vapors. In these cases, the object patterns lacked certain responses evoked by their major odorant mixture components. These data suggest the possibility of mixture response interactions and provide a foundation for understanding the neural coding of natural odor stimuli. PMID:20187145

Large field-of-view tiled grating structures for X-ray phase-contrast imaging

NASA Astrophysics Data System (ADS)

Schröter, Tobias J.; Koch, Frieder J.; Meyer, Pascal; Kunka, Danays; Meiser, Jan; Willer, Konstantin; Gromann, Lukas; Marco, Fabio D.; Herzen, Julia; Noel, Peter; Yaroshenko, Andre; Hofmann, Andreas; Pfeiffer, Franz; Mohr, Jürgen

2017-01-01

X-ray grating-based interferometry promises unique new diagnostic possibilities in medical imaging and materials analysis. To transfer this method from scientific laboratories or small-animal applications to clinical radiography applications, compact setups with a large field of view (FoV) are required. Currently the FoV is limited by the grating area, which is restricted due to the complex manufacturing process. One possibility to increase the FoV is tiling individual grating tiles to create one large area grating mounted on a carrier substrate. We investigate theoretically the accuracy needed for a tiling process in all degrees of freedom by applying a simulation approach. We show how the resulting precision requirements can be met using a custom-built frame for exact positioning. Precise alignment is achieved by comparing the fringe patterns of two neighboring grating tiles in a grating interferometer. With this method, the FoV can be extended to practically any desired length in one dimension. First results of a phase-contrast scanning setup with a full FoV of 384 mm × 24 mm show the suitability of this method.

Subtidal benthic megafauna in a productive and highly urbanised semi-enclosed bay (Ría de Vigo, NW Iberian Peninsula)

NASA Astrophysics Data System (ADS)

Aneiros, Fernando; Rubal, Marcos; Troncoso, Jesús S.; Bañón, Rafael

2015-11-01

The Ría de Vigo is a semi-enclosed bay with high primary productivity due to the influence of coastal upwelling-downwelling dynamics. The area is heavily populated and affected by numerous human activities, which lead to sediment modification. Epibenthic megafauna from the non-estuarine zones of this bay has been studied in order to describe its spatial distribution, testing possible differences between inner and outer areas. With that purpose, 75 sites have been sampled by means of a towing dredge. Megafauna was identified to the lowest taxonomic level possible, and each taxon counted and weighted. 113 different taxa were identified and a high spatial heterogeneity was observed in terms of abundance, biomass, taxa richness, diversity and evenness. Suspension-feeding molluscs dominated the innermost part of the studied area, and were substituted by echinoderms towards the external zones; this spatial pattern was also reflected in the results of multivariate analyses. These shifts in taxonomic and trophic guild composition of the assemblages have been tentatively related to differences in pollution levels and primary productivity along the main axis of the bay.

ELECTRON THERMAL CONDUCTION AS A POSSIBLE PHYSICAL MECHANISM TO MAKE THE INNER HELIOSHEATH THINNER

DOE Office of Scientific and Technical Information (OSTI.GOV)

Izmodenov, V. V.; Alexashov, D. B.; Ruderman, M. S., E-mail: izmod@ipmnet.ru

2014-11-01

We show that electron thermal conductivity may strongly affect the heliosheath plasma flow and the global pattern of the solar wind's interaction with the local interstellar medium. In particular, it leads to strong reduction of the inner heliosheath thickness, which makes it possible to explain (qualitatively) why Voyager 1 (V1) has crossed the heliopause at an unexpectedly small heliocentric distance of 122 AU. To estimate the effect of thermal conductivity, we consider a limiting case when thermal conduction is very effective. To do that, we assume the plasma flow in the entire heliosphere is nearly isothermal. Due to this effect,more » the heliospheric distance of the termination shock has increased by about 15 AU in the V1 direction compared with the adiabatic case with γ = 5/3. The heliospheric distance of the heliopause has decreased by about 27 AU. As a result, the thickness of the inner heliosheath in the model has decreased by about 42 AU and has become equal to 32 AU.« less

A Laminar Model for the Magnetic Field Structure in Bow-Shock Pulsar Wind Nebulae

NASA Astrophysics Data System (ADS)

Bucciantini, N.

2018-05-01

Bow Shock Pulsar Wind Nebulae are a class of non-thermal sources, that form when the wind of a pulsar moving at supersonic speed interacts with the ambient medium, either the ISM or in a few cases the cold ejecta of the parent supernova. These systems have attracted attention in recent years, because they allow us to investigate the properties of the pulsar wind in a different environment from that of canonical Pulsar Wind Nebulae in Supernova Remnants. However, due to the complexity of the interaction, a full-fledged multidimensional analysis is still laking. We present here a simplified approach, based on Lagrangian tracers, to model the magnetic field structure in these systems, and use it to compute the magnetic field geometry, for various configurations in terms of relative orientation of the magnetic axis, pulsar speed and observer direction. Based on our solutions we have computed a set of radio emission maps, including polarization, to investigate the variety of possible appearances, and how the observed emission pattern can be used to constrain the orientation of the system, and the possible presence of turbulence.

Emerging ferroelectric transistors with nanoscale channel materials: the possibilities, the limitations

NASA Astrophysics Data System (ADS)

Hong, Xia

2016-03-01

Combining the nonvolatile, locally switchable polarization field of a ferroelectric thin film with a nanoscale electronic material in a field effect transistor structure offers the opportunity to examine and control a rich variety of mesoscopic phenomena and interface coupling. It is also possible to introduce new phases and functionalities into these hybrid systems through rational design. This paper reviews two rapidly progressing branches in the field of ferroelectric transistors, which employ two distinct classes of nanoscale electronic materials as the conducting channel, the two-dimensional (2D) electron gas graphene and the strongly correlated transition metal oxide thin films. The topics covered include the basic device physics, novel phenomena emerging in the hybrid systems, critical mechanisms that control the magnitude and stability of the field effect modulation and the mobility of the channel material, potential device applications, and the performance limitations of these devices due to the complex interface interactions and challenges in achieving controlled materials properties. Possible future directions for this field are also outlined, including local ferroelectric gate control via nanoscale domain patterning and incorporating other emergent materials in this device concept, such as the simple binary ferroelectrics, layered 2D transition metal dichalcogenides, and the 4d and 5d heavy metal compounds with strong spin-orbit coupling.

Patterns of fracture and tidal stresses due to nonsynchronous rotation - Implications for fracturing on Europa

NASA Technical Reports Server (NTRS)

Helfenstein, P.; Parmentier, E. M.

1985-01-01

This study considers the global patterns of fracture that would result from nonsynchronous rotation of a tidally distorted planetary body. The incremental horizontal stresses in a thin elastic or viscous shell due to a small displacement of the axis of maximum tidal elongation are derived, and the resulting stress distributions are applied to interpret the observed pattern of fracture lineaments on Europa. The observed pattern of lineaments can be explained by nonsynchronous rotation if these features formed by tension fracturing and dike emplacement. Tension fracturing can occur for a small displacement of the tidal axis, so that the resulting lineaments may be consistent with other evidence suggesting a young age for the surface.

Quantum ballistic transport in strained epitaxial germanium

NASA Astrophysics Data System (ADS)

Gul, Y.; Holmes, S. N.; Newton, P. J.; Ellis, D. J. P.; Morrison, C.; Pepper, M.; Barnes, C. H. W.; Myronov, M.

2017-12-01

Large scale fabrication using Complementary Metal Oxide Semiconductor compatible technology of semiconductor nanostructures that operate on the principles of quantum transport is an exciting possibility now due to the recent development of ultra-high mobility hole gases in epitaxial germanium grown on standard silicon substrates. We present here a ballistic transport study of patterned surface gates on strained Ge quantum wells with SiGe barriers, which confirms the quantum characteristics of the Ge heavy hole valence band structure in 1-dimension. Quantised conductance at multiples of 2e2/h is a universal feature of hole transport in Ge up to 10 × (2e2/h). The behaviour of ballistic plateaus with finite source-drain bias and applied magnetic field is elucidated. In addition, a reordering of the ground state is observed.

Memory and neural networks on the basis of color centers in solids.

PubMed

Winnacker, Albrecht; Osvet, Andres

2009-11-01

Optical data recording is one of the most widely used and efficient systems of memory in the non-living world. The application of color centers in this context offers not only systems of high speed in writing and read-out due to a high degree of parallelism in data handling but also a possibility to set up models of neural networks. In this way, systems with a high potential for image processing, pattern recognition and logical operations can be constructed. A limitation to storage density is given by the diffraction limit of optical data recording. It is shown that this limitation can at least in principle be overcome by the principle of spectral hole burning, which results in systems of storage capacities close to the human brain system.

Terrestrial Myriametric Radio Burst Observed by IMAGE and Geotail Satellites

NASA Technical Reports Server (NTRS)

Fung, Shing F.; Hashimoto, KoZo; Kojima, Hirotsugu; Boardson, Scott A.; Garcia, Leonard N.; Matsumoto, Hiroshi; Green, James L.; Reinisch, Bodo W.

2013-01-01

We report the simultaneous detection of a terrestrial myriametric radio burst (TMRB) by IMAGE and Geotail on 19 August 2001. The TMRB was confined in time (0830-1006 UT) and frequency (12-50kHz). Comparisons with all known nonthermal myriametric radiation components reveal that the TMRB might be a distinct radiation with a source that is unrelated to the previously known radiation. Considerations of beaming from spin-modulation analysis and observing satellite and source locations suggest that the TMRB may have a fan beamlike radiation pattern emitted by a discrete, dayside source located along the poleward edge of magnetospheric cusp field lines. TMRB responsiveness to IMF Bz and By orientations suggests that a possible source of the TMRB could be due to dayside magnetic reconnection instigated by northward interplanetary field condition.

Prediction of Thermodynamic Equilibrium Temperature of Cu-Based Shape-Memory Smart Materials

NASA Astrophysics Data System (ADS)

Eskİl, Murat; Aldaş, Kemal; Özkul, İskender

2015-01-01

The thermodynamic equilibrium temperature ( T 0) is an important factor in the austenite and martensitic phases. In this study, the effects of alloying elements and heat treatments on T 0 temperature were investigated using Genetic Programming (GP) which has become one of the tools used in the study of condensed matter. Due to the changes in T 0, it is possible to analyze the changes in the entropy of the phase transitions. The data patterns of the GP formulation are based on well-established experimental results from the literature. The results of the GP-based formulation were compared with experimental results and found to be reliable with a very high correlation ( R 2 = 0.965 for training and R 2 = 0.952 for testing).

A project summary: Water and energy budget assessment for a non-tidal wetland in the Sacramento-San Joaquin delta

USGS Publications Warehouse

Anderson, Frank E.; Snyder, R.L.; Paw, U.K.T.; Drexler, Judith Z.

2004-01-01

The methods used to obtain universal cover coefficient (Kc) values for a non-tidal restored wetland in the Sacramento-San Joaquin river delta, US, during the summer of the year 2002 and to investigate possible differences during changing wind patterns are described. A micrometeorological tower over the wetland was established to quantify actual evapotranspiration (ETa) rates and surface energy fluxes for water and energy budget analysis. The eddy-covariance (EC) system was used to measure the surface energy budget data in the period from May 23 to November 6, 2002. The results show that K c values should be lower during westerly than northerly wind events during the midseason period due to the reduced vapor pressure deficit.

Placental sulfatase deficiency: maternal and fetal expression of steroid sulfatase deficiency and X-linked ichthyosis.

PubMed

Bradshaw, K D; Carr, B R

1986-07-01

PSD-X-linked ichthyosis are manifestations of a similar disorder of an inborn error of metabolism characterized by a deficiency of steroid sulfatase. The decreased enzyme activity is due to the absence of the expression of enzyme (steroid sulfatase) protein. Affected individuals with this disorder are males (X-linked inheritance) with a frequency of 1/2000 to 1/6000 births. Homozygous females from cosanguineous marriages have been reported with this disorder. The diagnosis is suspected and confirmed by: Low estriol excretion; Negative DHEAS loading test Increased DHEAS in amnionic fluid; Normal DHEAS in cord plasma; Possible delayed or abnormal labor patterns; Decreased sulfatase activity in the placenta, fibroblast, erythrocytes, lymphocytes or leukocytes of affected individuals; Development of ichthyosis in male infants at 2 to 3 months of age.

Fixation Patterns of Chinese Participants while Identifying Facial Expressions on Chinese Faces

PubMed Central

Xia, Mu; Li, Xueliu; Zhong, Haiqing; Li, Hong

2017-01-01

Two experiments in this study were designed to explore a model of Chinese fixation with four types of native facial expressions—happy, peaceful, sad, and angry. In both experiments, participants performed an emotion recognition task while their behaviors and eye movements were recorded. Experiment 1 (24 participants, 12 men) demonstrated that both eye fixations and durations were lower for the upper part of the face than for the lower part of the face for all four types of facial expression. Experiment 2 (20 participants, 6 men) repeated this finding and excluded the disturbance of fixation point. These results indicate that Chinese participants demonstrated a superiority effect for the lower part of face while interpreting facial expressions, possibly due to the influence of eastern etiquette culture. PMID:28446896

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, John; Olive, Keith A.; Velasco-Sevilla, Liliana

We consider supersymmetric grand unified theories with soft supersymmetry-breaking scalar masses m 0 specified above the GUT scale (super-GUTs) and patterns of Yukawa couplings motivated by upper limits on flavour-changing interactions beyond the Standard Model. If the scalar masses are smaller than the gaugino masses m 1/2, as is expected in no-scale models, the dominant effects of renormalisation between the input scale and the GUT scale are generally expected to be those due to the gauge couplings, which are proportional to m 1/2 and generation independent. In this case, the input scalar masses m 0 may violate flavour maximally, amore » scenario we call MaxSFV, and there is no supersymmetric flavour problem. As a result, we illustrate this possibility within various specific super-GUT scenarios that are deformations of no-scale gravity« less

Genetic population structure of the lionfish Pterois miles (Scorpaenidae, Pteroinae) in the Gulf of Aqaba and northern Red Sea.

PubMed

Kochzius, Marc; Blohm, Dietmar

2005-03-14

The aim of this study is to reveal gene flow between populations of the coral reef dwelling lionfish Pterois miles in the Gulf of Aqaba and northern Red Sea. Due to the fjord-like hydrography and topology of the Gulf of Aqaba, isolation of populations might be possible. Analysis of 5' mitochondrial control region sequences from 94 P. miles specimens detected 32 polymorphic sites, yielding 38 haplotypes. Sequence divergence among different haplotypes ranged from 0.6% to 9.9% and genetic diversity was high (h=0.85, pi=1.9%). AMOVA indicates panmixia between the Gulf of Aqaba and northern Red Sea, but analysis of migration pattern shows an almost unidirectional migration originating from the Red Sea.

Measuring adolescent science motivation

NASA Astrophysics Data System (ADS)

Schumm, Maximiliane F.; Bogner, Franz X.

2016-02-01

To monitor science motivation, 232 tenth graders of the college preparatory level ('Gymnasium') completed the Science Motivation Questionnaire II (SMQ-II). Additionally, personality data were collected using a 10-item version of the Big Five Inventory. A subsequent exploratory factor analysis based on the eigenvalue-greater-than-one criterion, extracted a loading pattern, which in principle, followed the SMQ-II frame. Two items were dropped due to inappropriate loadings. The remaining SMQ-II seems to provide a consistent scale matching the findings in literature. Nevertheless, also possible shortcomings of the scale are discussed. Data showed a higher perceived self-determination in girls which seems compensated by their lower self-efficacy beliefs leading to equality of females and males in overall science motivation scores. Additionally, the Big Five personality traits and science motivation components show little relationship.

Disk space and load time requirements for eye movement biometric databases

NASA Astrophysics Data System (ADS)

Kasprowski, Pawel; Harezlak, Katarzyna

2016-06-01

Biometric identification is a very popular area of interest nowadays. Problems with the so-called physiological methods like fingerprints or iris recognition resulted in increased attention paid to methods measuring behavioral patterns. Eye movement based biometric (EMB) identification is one of the interesting behavioral methods and due to the intensive development of eye tracking devices it has become possible to define new methods for the eye movement signal processing. Such method should be supported by an efficient storage used to collect eye movement data and provide it for further analysis. The aim of the research was to check various setups enabling such a storage choice. There were various aspects taken into consideration, like disk space usage, time required for loading and saving whole data set or its chosen parts.

KOI-676: An active star with two transiting planets and a third possible candidate detected with TTV

NASA Astrophysics Data System (ADS)

Ioannidis, P.; Schmitt, J.; Avdellidou, C.; von Essen, C.; Eric, A.

2013-09-01

We report the detection and characterization of two short period, Neptune sized planets, around the active star KOI-676. The orbital elements of both planets are not the expected ones, as they lead to miscalculation of the stellar parameters. We discuss various scenarios which could cause that discrepancy and we suggest that the reason is most probably the high eccentricities of the orbits. We use the Transit Timing Variations, detected in both planets' O-C diagrams to support our theory, while due to the lack of autocorrelation in their pattern we suggest the existence of a third, more massive, mutual inclined, outer perturber. To clarify our suggestions we use n-body simulations to model the TTVs and check the stability of the system.

Decoding a Dark Splotch

NASA Image and Video Library

2017-10-09

Geologists aren't quite sure what to make of the dark splotch in the middle of this image from NASA's Mars Reconnaisance Orbiter (MRO) -- one of several similar dark splotches that extend east and west for over 100 kilometers. From measurements made in infrared, this and other dark splotches have what we call "high thermal inertia," meaning that it heats up and cools down slowly. Scientists use thermal inertia to assess how rocky, sandy, or dusty a place is. A higher thermal inertia than the surrounding area means it's less dusty. Wavy, banded patterns in the dark splotch (possibly due to cross bedding from sand dunes that once occupied the area) were lithified into sandstone, and then eroded away. These clues could help geologists figure out what's going on there. https://photojournal.jpl.nasa.gov/catalog/PIA22042

Demographic, socioeconomic, and behavioral factors affecting patterns of tooth decay in the permanent dentition: Principal components and factor analyses

PubMed Central

Shaffer, John R.; Polk, Deborah E.; Feingold, Eleanor; Wang, Xiaojing; Cuenco, Karen T.; Weeks, Daniel E.; DeSensi, Rebecca S.; Weyant, Robert J.; Crout, Richard; McNeil, Daniel W.; Marazita, Mary L.

2012-01-01

Objectives Dental caries of the permanent dentition is a multi-factorial disease resulting from the complex interplay of endogenous and environmental risk factors. The disease is not easily quantified due to the innumerable possible combinations of carious lesions across individual tooth surfaces of the permanent dentition. Global measures of decay, such as the DMFS index (which was developed for surveillance applications), may not be optimal for studying the epidemiology of dental caries because they ignore the distinct patterns of decay across the dentition. We hypothesize that specific risk factors may manifest their effects on specific tooth surfaces leading to patterns of decay that can be identified and studied. In this study we utilized two statistical methods of extracting patterns of decay from surface-level caries data in order to create novel phenotypes with which to study the risk factors affecting dental caries. Methods Intra-oral dental examinations were performed on 1,068 participants aged 18 to 75 years to assess dental caries. The 128 tooth surfaces of the permanent dentition were scored as carious or not and used as input for principal components analysis (PCA) and factor analysis (FA), two methods of identifying underlying patterns without a priori knowledge of the patterns. Demographic (age, sex, birth year, race/ethnicity, and educational attainment), anthropometric (height, body mass index, waist circumference), endogenous (saliva flow), and environmental (tooth brushing frequency, home water source, and home water fluoride) risk factors were tested for association with the caries patterns identified by PCA and FA, as well as DMFS, for comparison. The ten strongest patterns (i.e., those that explain the most variation in the data set) extracted by PCA and FA were considered. Results The three strongest patterns identified by PCA reflected (i) global extent of decay (i.e., comparable to DMFS index), (ii) pit and fissure surface caries, and (iii) smooth surface caries, respectively. The two strongest patterns identified by FA corresponded to (i) pit and fissure surface caries and (ii) maxillary incisor caries. Age and birth year were significantly associated with several patterns of decay, including global decay/DMFS index. Sex, race, educational attainment, and tooth brushing were each associated with specific patterns of decay, but not with global decay/DMFS index. Conclusions Taken together, these results support the notion that caries experience is separable into patterns attributable to distinct risk factors. This study demonstrates the utility of such novel caries patterns as new outcomes for exploring the complex, multifactorial nature of dental caries. PMID:23106439

Demographic, socioeconomic, and behavioral factors affecting patterns of tooth decay in the permanent dentition: principal components and factor analyses.

PubMed

Shaffer, John R; Polk, Deborah E; Feingold, Eleanor; Wang, Xiaojing; Cuenco, Karen T; Weeks, Daniel E; DeSensi, Rebecca S; Weyant, Robert J; Crout, Richard; McNeil, Daniel W; Marazita, Mary L

2013-08-01

Dental caries of the permanent dentition is a multifactorial disease resulting from the complex interplay of endogenous and environmental risk factors. The disease is not easily quantitated due to the innumerable possible combinations of carious lesions across individual tooth surfaces of the permanent dentition. Global measures of decay, such as the DMFS index (which was developed for surveillance applications), may not be optimal for studying the epidemiology of dental caries because they ignore the distinct patterns of decay across the dentition. We hypothesize that specific risk factors may manifest their effects on specific tooth surfaces leading to patterns of decay that can be identified and studied. In this study, we utilized two statistical methods of extracting patterns of decay from surface-level caries data to create novel phenotypes with which to study the risk factors affecting dental caries. Intra-oral dental examinations were performed on 1068 participants aged 18-75 years to assess dental caries. The 128 tooth surfaces of the permanent dentition were scored as carious or not and used as input for principal components analysis (PCA) and factor analysis (FA), two methods of identifying underlying patterns without a priori knowledge of the patterns. Demographic (age, sex, birth year, race/ethnicity, and educational attainment), anthropometric (height, body mass index, waist circumference), endogenous (saliva flow), and environmental (tooth brushing frequency, home water source, and home water fluoride) risk factors were tested for association with the caries patterns identified by PCA and FA, as well as DMFS, for comparison. The ten strongest patterns (i.e. those that explain the most variation in the data set) extracted by PCA and FA were considered. The three strongest patterns identified by PCA reflected (i) global extent of decay (i.e. comparable to DMFS index), (ii) pit and fissure surface caries and (iii) smooth surface caries, respectively. The two strongest patterns identified by FA corresponded to (i) pit and fissure surface caries and (ii) maxillary incisor caries. Age and birth year were significantly associated with several patterns of decay, including global decay/DMFS index. Sex, race, educational attainment, and tooth brushing were each associated with specific patterns of decay, but not with global decay/DMFS index. Taken together, these results support the notion that caries experience is separable into patterns attributable to distinct risk factors. This study demonstrates the utility of such novel caries patterns as new outcomes for exploring the complex, multifactorial nature of dental caries. © 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Patterns, Severity, and Management of Maxillofacial Injuries in a Suburban South Western Nigeria Tertiary Center

PubMed Central

Ogunmuyiwa, Stella Aimiede; Gbolahan, Olalere Omoyosola; Ayantunde, Abiodun Abraham; Odewabi, Adenike Abidemi

2015-01-01

Background: Trauma remains a leading cause of maxillofacial injury globally. Changing etiological factors and patterns of maxillofacial injury continue to be reported and are largely modulated by socio-geographic and environmental factors. It is important to have an in-depth understanding of the pattern and etiology in a particular region before effective preventive measures can be developed. Aim: The aim was to evaluate the patterns, etiological factors, and management of maxillofacial injuries in Ogun state, Nigeria. Materials and Methods: A prospective descriptive cohort study of all consecutive patients that presented with maxillofacial injuries at our center between January and December 2013. Information about demographic data, types of maxillofacial and associated injury, etiology of injury, treatment received and complications were collected and analyzed. Results: Seventy patients presented with maxillofacial injury during the study period with a male to female ratio of 4:1. The age range was 9 months to 60 years with a mean of 30.11 ± standard deviation 14.97 years. Majority of the facial fractures were due to motorcycle related crashes. There were 57.1% mandibular fractures and 55.7% middle third fractures. Closed reduction with maxillo-mandibular fixation was the major method of treatment of facial fractures. Postoperative complications were observed in 11.4% of patients. Conclusion: Road traffic crashes (RTCs) remain the leading etiological factor of maxillofacial injuries in our center. Enforcement of stricter traffic regulations and possibly replacement of motorcycles with tricycles for commercial transportation may help to reduce the incidence of RTCs. PMID:25838765

A modern analysis of a historical pediatric disaster: the 1927 Bath school bombing.

PubMed

Kim, David; Mosher, Benjamin D; Morrison, Chet A; Parker-Lee, Carol; Opreanu, Razvan C; Stevens, Penny; Moore, Sarah; Kepros, John P

2010-10-01

Children have unique anatomy and physiology that may necessitate a unique approach to a pediatric surge. An analysis of the Bath school bombings of 1927, the largest pediatric terrorist disaster in U.S. history, provides an opportunity to gain perspective on pediatric patterns of injury and future disaster preparedness. Eighty-nine contemporary newspaper accounts, the official coroner's inquest, interviews, online resources, and the Michigan state archives of the disaster were reviewed with respect to the demographics, pattern of injury, gender, age, duration of hospitalization, relative distance of each classroom from the blast, and severity of injuries sustained using the Injury Severity Scale (ISS). Eighty-seven children and three teachers were unable to safely evacuate the building; 36 children (41%) were dead on-site, 40 sustained mild injuries (76.9%), nine sustained moderate injuries (17.3%), and one sustained serious injuries (1.9%). Mean ISS scores decreased with increasing relative distance of each classroom from the primary blast, while the classrooms involved in structural collapse had the highest initial mortality and ISS score. Patterns of injury sustained imply a predominance of crush and penetrating trauma. Mean ISS scores and initial mortality by classroom were a function of proximity to the blast and structural collapse. The pattern of injury closely approximates those of other pediatric disasters such as Columbine, Oklahoma City, and 911. The absence of severe abdominal trauma and one reported hospital mortality may reflect an initial under-triage of patients, possibly due to the medical technology of the times. Copyright © 2010 Elsevier Inc. All rights reserved.

High-precision real-time 3D shape measurement based on a quad-camera system

NASA Astrophysics Data System (ADS)

Tao, Tianyang; Chen, Qian; Feng, Shijie; Hu, Yan; Zhang, Minliang; Zuo, Chao

2018-01-01

Phase-shifting profilometry (PSP) based 3D shape measurement is well established in various applications due to its high accuracy, simple implementation, and robustness to environmental illumination and surface texture. In PSP, higher depth resolution generally requires higher fringe density of projected patterns which, in turn, lead to severe phase ambiguities that must be solved with additional information from phase coding and/or geometric constraints. However, in order to guarantee the reliability of phase unwrapping, available techniques are usually accompanied by increased number of patterns, reduced amplitude of fringe, and complicated post-processing algorithms. In this work, we demonstrate that by using a quad-camera multi-view fringe projection system and carefully arranging the relative spatial positions between the cameras and the projector, it becomes possible to completely eliminate the phase ambiguities in conventional three-step PSP patterns with high-fringe-density without projecting any additional patterns or embedding any auxiliary signals. Benefiting from the position-optimized quad-camera system, stereo phase unwrapping can be efficiently and reliably performed by flexible phase consistency checks. Besides, redundant information of multiple phase consistency checks is fully used through a weighted phase difference scheme to further enhance the reliability of phase unwrapping. This paper explains the 3D measurement principle and the basic design of quad-camera system, and finally demonstrates that in a large measurement volume of 200 mm × 200 mm × 400 mm, the resultant dynamic 3D sensing system can realize real-time 3D reconstruction at 60 frames per second with a depth precision of 50 μm.

Similar Fracture Patterns in Human Nose and Gothic Cathedral.

PubMed

Lee, Shu Jin; Tse, Kwong Ming; Lee, Heow Pueh

2015-10-01

This study proposes that the bony anatomy of the human nose and masonry structure of the Gothic cathedral are geometrically similar, and have common fracture patterns. We also aim to correlate the fracture patterns observed in patients' midface structures with those seen in the Gothic cathedral using computational approach. CT scans of 33 patients with facial fractures were examined and compared with computer simulations of both the Gothic cathedral and human nose. Three similar patterns were found: (1) Cracks of the nasal arch with crumpling of the vertical buttresses akin to the damage seen during minor earthquakes; (2) lateral deviation of the central nasal arch and collapse of the vertical buttresses akin to those due to lateral forces from wind and in major earthquakes; and (3) Central arch collapse seen as a result of collapse under excessive dead weight. Interestingly, the finding of occult nasal and septal fractures in the mandible fractures with absence of direct nasal trauma highlights the possibility of transmission of forces from the foundation to the arch leading to structural failure. It was also found that the structural buttresses of the Gothic cathedral delineate the vertical buttresses in the human midface structure. These morphologic similarities between the human nose and Gothic cathedral will serve as a basis to study the biomechanics of nasal fractures. Identification of structural buttresses in a skeletal structure has important implications for reconstruction as reestablishment of structural continuity restores normal anatomy and architectural stability of the human midface structure. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Splenophrenic portosystemic shunt in dogs with and without portal hypertension: can acquired and congenital porto-caval connections coexist?

PubMed Central

Ricciardi, M.

2016-01-01

The possible existence of the same pattern of porto-caval connection in dogs having a single congenital portosystemic shunt (CPSS) and in dogs having multiple acquired portosystemic shunt (MAPSS) secondary to portal hypertension (PH) was evaluated. Retrospective evaluation of all CT examinations of patients having portosystemic shunt (PSS) was performed in a 4-year time period. All anomalous porto-caval connections were assessed for anatomical pattern and compared with published veterinary literature. Records of 25 dogs were reviewed. 16 dogs had a single CPSS (CPSS group), and 9 dogs had multiple acquired PSS secondary to PH (APSS group). The splenophrenic shunt pattern was found in 3 dogs of the CPSS group as a single congenital anomaly without PH and in 2 dogs of the APSS group associated with MAPSS and ascites due to different hepatic diseases causing PH. These findings corroborate two hypotheses: 1) Splenophrenic PSS should be considered as a classical CPSS but if this is not sufficient to alleviate a PH developed after birth because of eventual hepatic or portal diseases, in this case ascites and acquired portal collaterals may develop. In this case, MAPSS and CPSS may coexist. 2) The pattern of splenophrenic PSS, classically described among CPSS, may develop as acquired portal collateral in dogs with PH and it should also be included in the category of APSS. These preliminary findings may be helpful in reconsidering the classical haemodynamics of porto-caval diseases, enrich the classification of APSS in dogs and refine the imaging evaluation of patients with PH. PMID:27882305

Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer's Disease and Late-Life Cognitive Disorders: A Systematic Review.

PubMed

Solfrizzi, Vincenzo; Custodero, Carlo; Lozupone, Madia; Imbimbo, Bruno P; Valiani, Vincenzo; Agosti, Pasquale; Schilardi, Andrea; D'Introno, Alessia; La Montagna, Maddalena; Calvani, Mariapaola; Guerra, Vito; Sardone, Rodolfo; Abbrescia, Daniela I; Bellomo, Antonello; Greco, Antonio; Daniele, Antonio; Seripa, Davide; Logroscino, Giancarlo; Sabbá, Carlo; Panza, Francesco

2017-01-01

In the last decade, the association between diet and cognitive function or dementia has been largely investigated. In the present article, we systematically reviewed observational studies published in the last three years (2014-2016) on the relationship among dietary factors and late-life cognitive disorders at different levels of investigation (i.e., dietary patterns, foods and food-groups, and dietary micro- and macronutrients), and possible underlying mechanisms of the proposed associations. From the reviewed evidence, the National Institute on Aging-Alzheimer's Association guidelines for Alzheimer's disease (AD) and cognitive decline due to AD pathology introduced some evidence suggesting a direct relation between diet and changes in the brain structure and activity. There was also accumulating evidence that combinations of foods and nutrients into certain patterns may act synergistically to provide stronger health effects than those conferred by their individual dietary components. In particular, higher adherence to a Mediterranean-type diet was associated with decreased cognitive decline. Moreover, also other emerging healthy dietary patterns such as the Dietary Approach to Stop Hypertension (DASH) and the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) diets were associated with slower rates of cognitive decline and significant reduction of AD rate. Furthermore, some foods or food groups traditionally considered harmful such as eggs and red meat have been partially rehabilitated, while there is still a negative correlation of cognitive functions with saturated fatty acids and a protective effect against cognitive decline of elevated fish consumption, high intake of monounsaturated fatty acids and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA.

Interference patterns of a horizontal electric dipole over layered dielectric media.

NASA Technical Reports Server (NTRS)

Tsang, L.; Kong, J. A.; Simmons, G.

1973-01-01

Interference patterns for electromagnetic fields due to a subsurface reflector below a layered lossy dielectric are calculated with the geometrical optics approximation for use in interpreting data to be collected on the moon by Apollo 17 as well as data currently being obtained on terrestrial glaciers. The radiating antenna lies on the surface. All six field components are calculated and studied. For the endfire solutions, the peak of the first reflected wave is found to be different from that of the broadside ones. To facilitate a physical discussion, we plotted the radiation patterns due to the antenna on the surface.

Patterns of Fracture and Tidal Stresses Due to Nonsynchronous Rotation: Implications for Fracturing on Europa

NASA Technical Reports Server (NTRS)

Parmentier, E. M.; Helfenstein, P.

1985-01-01

Global lineaments on Europa were interpreted as fractures in an icy crust. A variety of lineament types were identified, which appear to form a systematic pattern on the surface. For a synchronously rotating body, the patterns of fractures observed could be produced by a combination of stresses due to orbital recession, orbital eccentricity, and internal contraction. However, it was recently suggested that the forced eccentricity of Europa's orbit may result in nonsynchronous rotation. The hypothesis that fractures in a thin icy crust may have formed in response to stresses resulting from nonsynchronous rotation is studied.

Seasonal patterns of polycyclic aromatic hydrocarbons in digestive gland and arm of octopus (Octopus vulgaris) from the Northwest Atlantic.

PubMed

Semedo, Miguel; Oliveira, Marta; Gomes, Filipa; Reis-Henriques, Maria Armanda; Delerue-Matos, Cristina; Morais, Simone; Ferreira, Marta

2014-05-15

Among organic pollutants existing in coastal areas, polycyclic aromatic hydrocarbons (PAHs) are of great concern due to their ubiquity and carcinogenic potential. The aim of this study was to evaluate the seasonal patterns of PAHs in the digestive gland and arm of the common octopus (Octopus vulgaris) from the Northwest Atlantic Portuguese coast. In the different seasons, 18 PAHs were determined and the detoxification capacity of the species was evaluated. Ethoxyresorufin O-deethylase (EROD) and ethoxycoumarin O-deethylase (ECOD) activities were measured to assess phase I biotransformation capacity. Individual PAH ratios were used for major source (pyrolytic/petrogenic) analysis. Risks for human consumption were determined by the total toxicity equivalence approach. Generally, low levels of PAHs were detected in the digestive gland and in the arm of octopus, with a predominance of low molecular over high molecular weight compounds. PAHs exhibited seasonality in the concentrations detected and in their main emission sources. In the digestive gland, the highest total PAH levels were observed in autumn possibly related to fat availability in the ecosystem and food intake. The lack of PAH elimination observed in the digestive gland after captivity could be possibly associated to a low biotransformation capacity, consistent with the negligible/undetected levels of EROD and ECOD activity in the different seasons. The emission sources of PAHs found in the digestive gland varied from a petrogenic profile observed in winter to a pyrolytic pattern in spring. In the arm, the highest PAH contents were observed in June; nevertheless, levels were always below the regulatory limits established for food consumption. The carcinogenic potential calculated for all the sampling periods in the arm were markedly lower than the ones found in various aquatic species from different marine environments. The results presented in this study give relevant baseline data for environmental monitoring of organic pollution in coastal areas. Copyright © 2014 Elsevier B.V. All rights reserved.

Damage detection methodology under variable load conditions based on strain field pattern recognition using FBGs, nonlinear principal component analysis, and clustering techniques

NASA Astrophysics Data System (ADS)

Sierra-Pérez, Julián; Torres-Arredondo, M.-A.; Alvarez-Montoya, Joham

2018-01-01

Structural health monitoring consists of using sensors integrated within structures together with algorithms to perform load monitoring, damage detection, damage location, damage size and severity, and prognosis. One possibility is to use strain sensors to infer structural integrity by comparing patterns in the strain field between the pristine and damaged conditions. In previous works, the authors have demonstrated that it is possible to detect small defects based on strain field pattern recognition by using robust machine learning techniques. They have focused on methodologies based on principal component analysis (PCA) and on the development of several unfolding and standardization techniques, which allow dealing with multiple load conditions. However, before a real implementation of this approach in engineering structures, changes in the strain field due to conditions different from damage occurrence need to be isolated. Since load conditions may vary in most engineering structures and promote significant changes in the strain field, it is necessary to implement novel techniques for uncoupling such changes from those produced by damage occurrence. A damage detection methodology based on optimal baseline selection (OBS) by means of clustering techniques is presented. The methodology includes the use of hierarchical nonlinear PCA as a nonlinear modeling technique in conjunction with Q and nonlinear-T 2 damage indices. The methodology is experimentally validated using strain measurements obtained by 32 fiber Bragg grating sensors bonded to an aluminum beam under dynamic bending loads and simultaneously submitted to variations in its pitch angle. The results demonstrated the capability of the methodology for clustering data according to 13 different load conditions (pitch angles), performing the OBS and detecting six different damages induced in a cumulative way. The proposed methodology showed a true positive rate of 100% and a false positive rate of 1.28% for a 99% of confidence.

Pattern Laser Annealing by a Pulsed Laser

NASA Astrophysics Data System (ADS)

Komiya, Yoshio; Hoh, Koichiro; Murakami, Koichi; Takahashi, Tetsuo; Tarui, Yasuo

1981-10-01

Preliminary experiments with contact-type pattern laser annealing were made for local polycrystallization of a-Si, local evaporation of a-Si and local formation of Ni-Si alloy. These experiments showed that the mask patterns can be replicated as annealed regions with a resolution of a few microns on substrates. To overcome shortcomings due to the contact type pattern annealing, a projection type reduction pattern laser annealing system is proposed for resistless low temperature pattern forming processes.

DAMPs and influenza virus infection in ageing.

PubMed

Samy, Ramar Perumal; Lim, Lina H K

2015-11-01

Influenza A virus (IAV) is a serious global health problem worldwide due to frequent and severe outbreaks. IAV causes significant morbidity and mortality in the elderly population, due to the ineffectiveness of the vaccine and the alteration of T cell immunity with ageing. The cellular and molecular link between ageing and virus infection is unclear and it is possible that damage associated molecular patterns (DAMPs) may play a role in the raised severity and susceptibility of virus infections in the elderly. DAMPs which are released from damaged cells following activation, injury or cell death can activate the immune response through the stimulation of the inflammasome through several types of receptors found on the plasma membrane, inside endosomes after endocytosis as well as in the cytosol. In this review, the detriment in the immune system during ageing and the links between influenza virus infection and ageing will be discussed. In addition, the role of DAMPs such as HMGB1 and S100/Annexin in ageing, and the enhanced morbidity and mortality to severe influenza infection in ageing will be highlighted. Copyright © 2015 Elsevier B.V. All rights reserved.

Investigation of potentially toxic heavy metals in different organic wastes used to fertilize market garden crops.

PubMed

Tella, M; Doelsch, E; Letourmy, P; Chataing, S; Cuoq, F; Bravin, M N; Saint Macary, H

2013-01-01

The benefits of using organic waste as fertilizer and soil amendment should be assessed together with the environmental impacts due to the possible presence of heavy metals (HMs). This study involved analysing major element and HM contents in raw and size-fractionated organic wastes (17 sewage sludges and composts) from developed and developing countries. The overall HM concentration pattern showed an asymmetric distribution due to the presence of some wastes with extremely high concentrations. HM concentrations were correlated with the size of cities or farms where the wastes had been produced, and HM were differentiated with respect to their origins (geogenic: Cr-Ni; anthropogenic agricultural and urban: Cu-Zn; anthropogenic urban: Cd-Pb). Size fractionation highlighted Cd, Cu, Zn and Pb accumulation in fine size fractions, while Cr and Ni were accumulated in the coarsest. HM associations with major elements revealed inorganic (Al, Fe, etc.) bearing phases for Cr and Ni, and sulfur or phosphorus species for Cd, Cu Pb and Zn. Copyright © 2012 Elsevier Ltd. All rights reserved.

Substantial changes in hemocyte parameters of Manila clam Ruditapes philippinarum two years after the Hebei Spirit oil spill off the west coast of Korea.

PubMed

Hong, Hyun-Ki; Donaghy, Ludovic; Kang, Chang-Keun; Kang, Hyun-Sil; Lee, Hee-Jung; Park, Heung-Sik; Choi, Kwang-Sik

2016-07-15

Two years after the Hebei Spirit oil spill occurred off the west coast of Korea, we determined sub-lethal effects of the spilled oil on hemocyte parameters of Ruditapes philippinarum in the damaged areas. Clams in the spilled sites displayed unusually high proportion of granulocytes, which may result in higher phagocytosis capacity and reactive oxygen species production. Hemocytes in clams from the polluted sites also displayed less DNA damage and mortality than in the control site, possibly due to a faster phagocytosis of the impaired cells. Glycogen, the major energetic reserve, was depleted in clams from the spilled sites, potentially due to energetic consumption for maintenance of a large pool of granulocytes, detoxification processes and oxidative stress. Modified hemocyte parameters in clams in the spilled area, may reflect sub-lethal physiological stresses caused by the residual oils in the sediment, in conjunction with environmental modifications such as food availability and pathogens pattern. Copyright © 2016 Elsevier Ltd. All rights reserved.

The clinical pattern of diabetes Insipidus in a large university hospital in the Middle East.

PubMed

Babiker, Amir M I; Al Jurayyan, Nasir A M; Al Jurayyan, Rushaid N A; Al Gadi, Iman; Drop, Stenvert L S

2015-04-01

Diabetes insipidus is a rare but serious endocrine disorder. Paediatric patients were evaluated for polyuria at King Khalid University Hospital, Riyadh, Saudi Arabia, over a decade (2000-13). Relevant clinical examination and/or a triad of high serum osmolality, hypernatremia and low urine osmolality due to increased urine output confirmed the diagnosis. Water deprivation test was required in some cases with non-classic presentations. Appropriate brain imaging was performed whenever central diabetes insipidus (CDI) was suspected. Twenty-eight patients, 15 males (53.6%) and 13 females (46.4%), aged 0-17 years (mean: 6 years) were included. The calculated period prevalence was 7 in 10,000. In our cohort, 60.7% (17 of 28 patients) had CDI, 21.4% (6 of 28) were diagnosed with nephrogenic diabetes insipidus (NDI) and 17.9% (5 of 30) had psychogenic polydipsia. CDI was due to variable aetiology. Though CDI was the commonest, NDI was not a rare encounter in our community, possibly because of high consanguineous marriages. © The Author [2015]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Using the graphene Moiré pattern for the trapping of C60 and homoepitaxy of graphene.

PubMed

Lu, Jiong; Yeo, Pei Shan Emmeline; Zheng, Yi; Yang, Zhiyong; Bao, Qiaoliang; Gan, Chee Kwan; Loh, Kian Ping

2012-01-24

The graphene Moiré superstructure offers a complex landscape of humps and valleys to molecules adsorbing and diffusing on it. Using C(60) molecules as the classic hard sphere analogue, we examine its assembly and layered growth on this corrugated landscape. At the monolayer level, the cohesive interactions of C(60) molecules adsorbing on the Moiré lattice freeze the molecular rotation of C(60) trapped in the valley sites, resulting in molecular alignment of all similarly trapped C(60) molecules at room temperature. The hierarchy of adsorption potential well on the Moiré lattice causes diffusion-limited dendritic growth of C(60) films, as opposed to isotropic growth observed on a smooth surface like graphite. Due to the strong binding energy of the C(60) film, part of the dentritic C(60) films polymerize at 850 K and act as solid carbon sources for graphene homoepitaxy. Our findings point to the possibility of using periodically corrugated graphene in molecular spintronics due to its ability to trap and align organic molecules at room temperature. © 2011 American Chemical Society

Resonant x-ray diffraction revealing chemical disorder in sputtered L10 FeNi on Si(0 0 1)

NASA Astrophysics Data System (ADS)

Frisk, Andreas; Lindgren, Bengt; Pappas, Spiridon D.; Johansson, Erik; Andersson, Gabriella

2016-10-01

In the search for new rare earth free permanent magnetic materials, FeNi with a L10 structure is a possible candidate. We have synthesized the phase in the thin film form by sputtering onto HF-etched Si(0 0 1) substrates. Monatomic layers of Fe and Ni were alternately deposited on a Cu buffer layer, all of which grew epitaxially on the Si substrates. A good crystal structure and epitaxial relationship was confirmed by in-house x-ray diffraction (XRD). The chemical order, which to some part is the origin of an uniaxial magnetic anisotropy, was measured by resonant XRD. The 0 0 1 superlattice reflection was split in two symmetrically spaced peaks due to a composition modulation of the Fe and Ni layers. Furthermore the influence of roughness induced chemical anti-phase domains on the RXRD pattern is exemplified. A smaller than expected magnetic uniaxial anisotropy energy was obtained, which is partly due to the composition modulations, but the major reason is concluded to be the Cu buffer surface roughness.

Resonant x-ray diffraction revealing chemical disorder in sputtered L10 FeNi on Si(0 0 1).

PubMed

Frisk, Andreas; Lindgren, Bengt; Pappas, Spiridon D; Johansson, Erik; Andersson, Gabriella

2016-10-12

In the search for new rare earth free permanent magnetic materials, FeNi with a L10 structure is a possible candidate. We have synthesized the phase in the thin film form by sputtering onto HF-etched Si(0 0 1) substrates. Monatomic layers of Fe and Ni were alternately deposited on a Cu buffer layer, all of which grew epitaxially on the Si substrates. A good crystal structure and epitaxial relationship was confirmed by in-house x-ray diffraction (XRD). The chemical order, which to some part is the origin of an uniaxial magnetic anisotropy, was measured by resonant XRD. The 0 0 1 superlattice reflection was split in two symmetrically spaced peaks due to a composition modulation of the Fe and Ni layers. Furthermore the influence of roughness induced chemical anti-phase domains on the RXRD pattern is exemplified. A smaller than expected magnetic uniaxial anisotropy energy was obtained, which is partly due to the composition modulations, but the major reason is concluded to be the Cu buffer surface roughness.

Dietary fibre intakes of individuals with different eating patterns.

PubMed

Davies, G J; Crowder, M; Dickerson, J W

1985-04-01

This study was undertaken to provide evidence of the variation in the diet necessary to incorporate a high fibre content. Food intakes were measured for seven days by 51 subjects who were either omnivores, vegetarians or vegans. Omnivores consumed the least fibre (23 g), vegetarians significantly more (37 g) and vegans the most (47 g). Men had higher intakes (44 g) than women (30.5 g). Vegans ate the most cereal fibre, but high intake of fibre by both vegetarian groups were due to their preference for unrefined foods, particularly bread. Higher intakes of vegetable fibre by both vegetarian groups were due to high consumption of pulses. Total dietary fibre was significantly related to cereal fibre. As the percentage of fibre increased, the percentage of energy derived from protein decreased. Fat contributed less energy (34 per cent) to the vegan than to the omnivore diet (41 per cent). This study showed that high fibre intake can be achieved on an omnivorous diet and the observation that high fibre diets are possible when the energy content is low, is of relevance to slimming regimes.

78 FR 53165 - Agency Information Collection Activities: Submission to OMB for Reinstatement, With Change, of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-28

... identifying possible discriminatory lending patterns and enforcing anti-discrimination statutes. The... patterns and enforcing anti-discrimination statutes. Respondents: Credit unions. Estimated No. of...

Dynamic measurement of surface strain distribution on the foot during walking.

PubMed

Ito, Kohta; Maeda, Kosuke; Fujiwara, Ikumi; Hosoda, Koh; Nagura, Takeo; Lee, Taeyong; Ogihara, Naomichi

2017-05-01

To clarify the mechanism underlying the development of foot disorders such as diabetic ulcers and deformities, it is important to understand how the foot surface elongates and contracts during gait. Such information is also helpful for improving the prevention and treatment of foot disorders. We therefore measured temporal changes in the strain distribution on the foot surface during human walking. Five adult male participants walked across a glass platform placed over an angled mirror set in a wooden walkway at a self-selected speed and the dorsolateral and plantar surfaces of the foot were filmed using two pairs of synchronized high-speed cameras. Three-dimensional (3D) digital image correlation was used to quantify the spatial strain distribution on the foot surface with respect to that during quiet standing. Using the proposed method, we observed the 3D patterns of foot surface strain distribution during walking. Large strain was generated around the ball on the plantar surface of the foot throughout the entire stance phase, due to the windlass mechanism. The dorsal surface around the cuboid was stretched in the late stance phase, possibly due to lateral protruding movement of the cuboid. It may be possible to use this technique to non-invasively estimate movements of the foot bones under the skin using the surface strain distribution. The proposed technique may be an effective tool with which to analyze foot deformation in the fields of diabetology, clinical orthopedics, and ergonomics. Copyright © 2017. Published by Elsevier Ltd.

Pathological Gambling Associated With Aripiprazole or Dopamine Replacement Therapy

PubMed Central

Grall-Bronnec, Marie; Sauvaget, Anne; Perrouin, Fanny; Leboucher, Juliette; Etcheverrigaray, François; Challet-Bouju, Gaëlle; Gaboriau, Louise; Derkinderen, Pascal; Jolliet, Pascale; Victorri-Vigneau, Caroline

2016-01-01

Background In the last 10 years, dopamine replacement therapy (DRT) has become a well-known risk factor for developing an impulse control disorder, such as gambling disorder (GD). Another medication, aripiprazole (ARI), has been more recently identified as another risk factor. Dopamine replacement therapy and ARI share a dopamine agonist action. Our work aimed at comparing patients with PG according to their treatment with DRT or ARI. Methods Two methods were combined—a systematic review concentrated on case reports and the analysis of a French disordered gamblers cohort focused on patients using ARI or DRT at inclusion. Results We reported 48 cases of GD possibly due to DRT and 17 cases of GD possibly due to ARI. Because of their standardized assessment, only the EVALJEU patients could be compared. Two clinical patterns emerged. Patients in the ARI group were young, impulsive, and high novelty seekers and had a history of substance misuse. Their first gambling experience occurred during adolescence. Conversely, patients in the DRT group were old, and they began gambling late in life. They showed low levels of gambling-related cognition. Conclusions Patients in the ARI group seemed to be more severe pathological gamblers than patients in the DRT group. Aripiprazole is a partial D2 receptor agonist, whereas DRT includes full D2 receptor agonist. The trigger mechanism of PG development is complex and cannot only be attributed only to the pharmacodynamic effects of dopaminergic drugs. Indeed, individual vulnerability factors and environmental factors need to be considered. PMID:26658263

Controlling orientational order in block copolymers using low-intensity magnetic fields

PubMed Central

Choo, Youngwoo; Kawabata, Kohsuke; Kaufman, Gilad; Feng, Xunda; Di, Xiaojun; Rokhlenko, Yekaterina; Mahajan, Lalit H.; Ndaya, Dennis; Kasi, Rajeswari M.

2017-01-01

The interaction of fields with condensed matter during phase transitions produces a rich variety of physical phenomena. Self-assembly of liquid crystalline block copolymers (LC BCPs) in the presence of a magnetic field, for example, can result in highly oriented microstructures due to the LC BCP’s anisotropic magnetic susceptibility. We show that such oriented mesophases can be produced using low-intensity fields (<0.5 T) that are accessible using permanent magnets, in contrast to the high fields (>4 T) and superconducting magnets required to date. Low-intensity field alignment is enabled by the addition of labile mesogens that coassemble with the system’s nematic and smectic A mesophases. The alignment saturation field strength and alignment kinetics have pronounced dependences on the free mesogen concentration. Highly aligned states with orientation distribution coefficients close to unity were obtained at fields as small as 0.2 T. This remarkable field response originates in an enhancement of alignment kinetics due to a reduction in viscosity, and increased magnetostatic energy due to increases in grain size, in the presence of labile mesogens. These developments provide routes for controlling structural order in BCPs, including the possibility of producing nontrivial textures and patterns of alignment by locally screening fields using magnetic nanoparticles. PMID:29078379

Maternal and neonatal outcomes in labor and at delivery when long QT syndrome is present.

PubMed

Tanaka, Hiroaki; Katsuragi, Shinji; Tanaka, Kayo; Sawada, Masami; Iwanaga, Naoko; Yoshimatsu, Jun; Ikeda, Tomoaki

2016-01-01

Women during labor may be susceptible to torsades de pointes (TdP), which may cause the fetal condition to deteriorate. The aim of the present investigation was to analyze maternal and fetal outcomes during labor when long QT syndrome (LQTS) was present. We examined the maternal and neonatal outcomes of 25 pregnancies (18 women) with LQT between 1995 and 2012 at the Department of Perinatology, National Cardiovascular Center, Japan. Maternal and neonatal outcomes including cardiovascular events, cardiovascular events within a week after delivery, caesarean delivery rate, still births, preterm births, and non-reassuring fetal heart rate pattern (NRFHR) during labor were investigated. All the mothers survived, and no cardiovascular events occurred in labor or postpartum due to LQTS in either vaginal delivery or caesarean delivery. A total of 23 women (92%) had used beta blockers in this study. Caesarean delivery was performed due to NRFHR during labor in 5 pregnancies (20%). Delivery when LQTS is present has a low likelihood of cardiovascular events, but pregnancy with LQTS had a higher caesarean delivery rate due to NRFHR in labor. Most women used beta blockers in this study, and it is possible that beta blocker use prevents cardiovascular events during labor. NRFHR during labor may be related with inherited LQT through the mother.

Multipolar response of nonspherical silicon nanoparticles in the visible and near-infrared spectral ranges

NASA Astrophysics Data System (ADS)

Terekhov, Pavel D.; Baryshnikova, Kseniia V.; Artemyev, Yuriy A.; Karabchevsky, Alina; Shalin, Alexander S.; Evlyukhin, Andrey B.

2017-07-01

Spectral multipole resonances of parallelepiped-, pyramid-, and cone-like shaped silicon nanoparticles excited by linearly polarized light waves are theoretically investigated. The numerical finite element method is applied for the calculations of the scattering cross sections as a function of the nanoparticles geometrical parameters. The roles of multipole moments (up to the third order) in the scattering process are analyzed using the semianalytical multipole decomposition approach. The possibility of scattering pattern configuration due to the tuning of the multipole contributions to the total scattered waves is discussed and demonstrated. It is shown that cubic nanoparticles can provide a strong isotropic side scattering with minimization of the scattering in forward and backward directions. In the case of the pyramidal and conical nanoparticles the total suppression of the side scattering can be obtained. It was found that due to the shape factor of the pyramidal and conical nanoparticles their electric toroidal dipole resonance can be excited in the spectral region of the first electric and magnetic dipole resonances. The influence of the incident light directions on the optical response of the pyramidal and conical nanoparticles is discussed. The obtained results provide important information that can be used for the development of nanoantennas with improved functionality due to the directional scattering effects.

New constraints on the 3D shear wave velocity structure of the upper mantle underneath Southern Scandinavia revealed from non-linear tomography

NASA Astrophysics Data System (ADS)

Wawerzinek, B.; Ritter, J. R. R.; Roy, C.

2013-08-01

We analyse travel times of shear waves, which were recorded at the MAGNUS network, to determine the 3D shear wave velocity (vS) structure underneath Southern Scandinavia. The travel time residuals are corrected for the known crustal structure of Southern Norway and weighted to account for data quality and pick uncertainties. The resulting residual pattern of subvertically incident waves is very uniform and simple. It shows delayed arrivals underneath Southern Norway compared to fast arrivals underneath the Oslo Graben and the Baltic Shield. The 3D upper mantle vS structure underneath the station network is determined by performing non-linear travel time tomography. As expected from the residual pattern the resulting tomographic model shows a simple and continuous vS perturbation pattern: a negative vS anomaly is visible underneath Southern Norway relative to the Baltic Shield in the east with a contrast of up to 4% vS and a sharp W-E dipping transition zone. Reconstruction tests reveal besides vertical smearing a good lateral reconstruction of the dipping vS transition zone and suggest that a deep-seated anomaly at 330-410 km depth is real and not an inversion artefact. The upper part of the reduced vS anomaly underneath Southern Norway (down to 250 km depth) might be due to an increase in lithospheric thickness from the Caledonian Southern Scandes in the west towards the Proterozoic Baltic Shield in Sweden in the east. The deeper-seated negative vS anomaly (330-410 km depth) could be caused by a temperature anomaly possibly combined with effects due to fluids or hydrous minerals. The determined simple 3D vS structure underneath Southern Scandinavia indicates that mantle processes might influence and contribute to a Neogene uplift of Southern Norway.

Epidemiological relationship of human and swine Streptococcus suis isolates.

PubMed

Tarradas, C; Luque, I; de Andrés, D; Abdel-Aziz Shahein, Y E; Pons, P; González, F; Borge, C; Perea, A

2001-06-01

Two cases of meningitis due to Streptococcus suis in humans are reported here. A butcher and an abattoir worker were referred to a health centre in Castellón (Spain) with fever and symptoms of meningitis. After adequate treatment, a slight hipoacusia persisted as sequelae in both cases. Colonies of S. suis group R, serotype 2 and phenotype MRP+EF+ were isolated from cerebroespinal fluid. Epidemiological studies showed that both workers had in common the handling of pork meat of slaughtered healthy pigs from three closed farms. A study of the tonsils from apparently healthy, slaughtered pigs was carried out. A total of 234 tonsillar samples were obtained and 81 strains of S. suis were isolated from them. Serotype 2 appeared to be the most frequent (50.6%), and the analysis for phenotype showed a high percentage of tonsillar strains with the phenotype MRP+EF+ (35.9%). The humans and 28 tonsillar swine strains showed a similar profile (S. suis group R, serotype 2 and phenotype MRP+EF+). A total of 26 of the swine isolates were analysed by ribotyping using EcoRI. The human strains showed the same six-band hybridization pattern that shared five bands with the pattern most frequently shown by most of the tonsillar N. suis group R, serotype 2 and phenotype MRP+EF+ strains, differing only in the lightest, faintest band which was slightly less anodical in human (> or = 1.8 kb) than in swine (approximately 1.8 kb). From these results, both groups of strains, humans and porcine, showed differences; how can these differences in the pattern of ribotyping be explained if they should have the same origin? Is it possible that they have undergone an adaptation to the new host or perhaps the modification is due to other unknown causes? Further studies in this area are required in order to answer these questions.

Phonological and Lexical Effects in Verbal Recall by Children with Specific Language Impairments

PubMed Central

Coady, Jeffry A.; Mainela-Arnold, Elina; Evans, Julia L.

2014-01-01

Background & Aims The present study examined how phonological and lexical knowledge influences memory in children with specific language impairments (SLI). Previous work showed recall advantages for typical adults and children due to word frequency and phonotactic pattern frequency and a recall disadvantage due to phonological similarity among words. While children with SLI have well documented memory difficulties, it is not clear whether these language knowledge factors also influence recall in this population. Methods & Procedures 16 children with SLI (mean age 10;2) and CAM controls recalled lists of words differing in phonological similarity, word frequency, and phonotactic pattern frequency. While previous studies used a small set of words appearing in multiple word lists, the current study used a larger set of words, without replacement, so that children could not gain practice with individual test items. Outcomes & Results All main effects were significant. Interactions revealed that children with SLI were affected by similarity, but less so than their peers, comparably affected by word frequency, and unaffected by phonotactic pattern frequency. Conclusions Results due to phonological similarity suggest that children with SLI use less efficient encoding, while results due to word frequency and phonotactic pattern frequency were mixed. Children with SLI used coarse-grained language knowledge (word frequency) comparably to peers, but were less able to use fine-grained knowledge (phonotactic pattern frequency). Paired with phonological similarity results, this suggests that children with SLI have difficulty establishing robust phonological knowledge for use in language tasks. PMID:23472955

Late Middle Paleolithic Adaptations and Their Possible Consequences

ERIC Educational Resources Information Center

Binford, Sally R.

1970-01-01

Correlates paleontological and archaeological data and proposes that evolutionary changes in the "Progressive Neanderthals resulted from changes in hunting patterns with accompanying changes in tool manufacture, social grouping, and mating patterns. (EB)

Methylation Pattern of Radish (Raphanus sativus) Nuclear Ribosomal RNA Genes 1

PubMed Central

Delseny, Michel; Laroche, Monique; Penon, Paul

1984-01-01

The methylation pattern of radish Raphanus sativus nuclear rDNA has been investigated using the Hpa II, Msp I, and Hha I restriction enzymes. The presence of numerous target sites for these enzymes has been shown using cloned rDNA fragments. A large fraction of the numerous rDNA units are heavily methylated, being completely resistant to Hpa II and Hpa I. However, specific sites are constantly available in another fraction of the units and are therefore unmethylated. The use of different probes allowed us to demonstrate that hypomethylated sites are present in different regions. Major hypomethylated Hha I sites have been mapped in the 5′ portion of 25S rRNA coding sequence. Among the hypomethylated fraction, different methylation patterns coexist. It has been possible to demonstrate that methylation patterns are specific for particular units. The Hha I pattern of rDNA in tissues of different developmental stages was analyzed. Evidence for possible tissue specific differences in the methylation pattern is reported. Images Fig. 2 Fig. 3 Fig. 5 PMID:16663896

Methodology for prediction and estimation of consequences of possible atmospheric releases of hazardous matter: "Kursk" submarine study

NASA Astrophysics Data System (ADS)

Baklanov, A.; Mahura, A.; Sørensen, J. H.

2003-06-01

There are objects with some periods of higher than normal levels of risk of accidental atmospheric releases (nuclear, chemical, biological, etc.). Such accidents or events may occur due to natural hazards, human errors, terror acts, and during transportation of waste or various operations at high risk. A methodology for risk assessment is suggested and it includes two approaches: 1) probabilistic analysis of possible atmospheric transport patterns using long-term trajectory and dispersion modelling, and 2) forecast and evaluation of possible contamination and consequences for the environment and population using operational dispersion modelling. The first approach could be applied during the preparation stage, and the second - during the operation stage. The suggested methodology is applied on an example of the most important phases (lifting, transportation, and decommissioning) of the ``Kursk" nuclear submarine operation. It is found that the temporal variability of several probabilistic indicators (fast transport probability fields, maximum reaching distance, maximum possible impact zone, and average integral concentration of 137Cs) showed that the fall of 2001 was the most appropriate time for the beginning of the operation. These indicators allowed to identify the hypothetically impacted geographical regions and territories. In cases of atmospheric transport toward the most populated areas, the forecasts of possible consequences during phases of the high and medium potential risk levels based on a unit hypothetical release (e.g. 1 Bq) are performed. The analysis showed that the possible deposition fractions of 10-11 (Bq/m2) over the Kola Peninsula, and 10-12 - 10-13 (Bq/m2) for the remote areas of the Scandinavia and Northwest Russia could be observed. The suggested methodology may be used successfully for any potentially dangerous object involving risk of atmospheric release of hazardous materials of nuclear, chemical or biological nature.

Methodology for prediction and estimation of consequences of possible atmospheric releases of hazardous matter: "Kursk"? submarine study

NASA Astrophysics Data System (ADS)

Baklanov, A.; Mahura, A.; Sørensen, J. H.

2003-03-01

There are objects with some periods of higher than normal levels of risk of accidental atmospheric releases (nuclear, chemical, biological, etc.). Such accidents or events may occur due to natural hazards, human errors, terror acts, and during transportation of waste or various operations at high risk. A methodology for risk assessment is suggested and it includes two approaches: 1) probabilistic analysis of possible atmospheric transport patterns using long-term trajectory and dispersion modelling, and 2) forecast and evaluation of possible contamination and consequences for the environment and population using operational dispersion modelling. The first approach could be applied during the preparation stage, and the second - during the operation stage. The suggested methodology is applied on an example of the most important phases (lifting, transportation, and decommissioning) of the "Kursk" nuclear submarine operation. It is found that the temporal variability of several probabilistic indicators (fast transport probability fields, maximum reaching distance, maximum possible impact zone, and average integral concentration of 137Cs) showed that the fall of 2001 was the most appropriate time for the beginning of the operation. These indicators allowed to identify the hypothetically impacted geographical regions and territories. In cases of atmospheric transport toward the most populated areas, the forecasts of possible consequences during phases of the high and medium potential risk levels based on a unit hypothetical release are performed. The analysis showed that the possible deposition fractions of 1011 over the Kola Peninsula, and 10-12 - 10-13 for the remote areas of the Scandinavia and Northwest Russia could be observed. The suggested methodology may be used successfully for any potentially dangerous object involving risk of atmospheric release of hazardous materials of nuclear, chemical or biological nature.

Turtle soup, Prohibition, and the population genetic structure of Diamondback Terrapins (Malaclemys terrapin).

PubMed

Converse, Paul E; Kuchta, Shawn R; Hauswaldt, J Susanne; Roosenburg, Willem M

2017-01-01

Diamondback terrapins (Malaclemys terrapin) were a popular food item in early twentieth century America, and were consumed in soup with sherry. Intense market demand for terrapin meat resulted in population declines, notably along the Atlantic seaboard. Efforts to supply terrapins to markets resulted in translocation events, as individuals were moved about to stock terrapin farms. However, in 1920 the market for turtle soup buckled with the enactment of the eighteenth amendment to the United States' Constitution-which initiated the prohibition of alcoholic drinks-and many terrapin fisheries dumped their stocks into local waters. We used microsatellite data to show that patterns of genetic diversity along the terrapin's coastal range are consistent with historical accounts of translocation and cultivation activities. We identified possible instances of human-mediated dispersal by estimating gene flow over historical and contemporary timescales, Bayesian model testing, and bottleneck tests. We recovered six genotypic clusters along the Gulf and Atlantic coasts with varying degrees of admixture, including increased contemporary gene flow from Texas to South Carolina, from North Carolina to Maryland, and from North Carolina to New York. In addition, Bayesian models incorporating translocation events outperformed stepping-stone models. Finally, we were unable to detect population bottlenecks, possibly due to translocation reintroducing genetic diversity into bottlenecked populations. Our data suggest that current patterns of genetic diversity in the terrapin were altered by the demand for turtle soup followed by the enactment of alcohol prohibition. In addition, our study shows that population genetic tools can elucidate metapopulation dynamics in taxa with complex genetic histories impacted by anthropogenic activities.

Chirped-Pulse and Cavity Based Fourier Transform Microwave Spectroscopy of the Methyl Lactate-Ammonia Adduct

NASA Astrophysics Data System (ADS)

Thomas, Javix; Sukhorukov, Oleksandr; Jaeger, Wolfgang; Xu, Yunjie

2012-06-01

The hydrogen bonded complex of ammonia with methyl lactate, a chiral alpha-hydroxyester, has been studied using rotational spectroscopy and high level ab initio calculations. Previous studies showed that methyl lactate can exist in a number of conformers. However, only the most stable one which has an intramolecular hydrogen bonded ring formed with its alcoholic hydroxyl and its carbonyl oxygen atom was detected experimentally An extensive ab initio search has been performed to locate all possible low energy conformers of the methyl lactate-ammonia contact pair. Five lowest energy conformers have been identified at the MP2/6-311++G(d,p) level. The lowest energy conformer favors an insertion arrangement, where ammonia is inserted into the existing intramolecular hydrogen bonded ring in the most stable methyl lactate conformer. Broadband scans for the rotational spectra of possible binary conformers have been carried out using a chirped-pulse Fourier transform microwave (FTMW) instrument. The most stable binary adduct was identified and assigned. The final frequency measurements have been done with a cavity based FTMW instrument. The spectrum observed shows complicated fine and hyperfine splitting patterns, likely due to the internal rotations of the methyl groups of methyl lactate and that of ammonia, as well as the 14N quadrupolar nucleus. The binary adduct with 15NH3 has also been studied to simplify the splitting pattern and to aid the assignments of the extensive splittings. The isotopic data and the fine and hyperfine structures will be discussed in terms of internal rotation dynamics and geometry of the hydrogen bonded adduct.

Creation of wettability contrast patterns on metallic surfaces via pen drawn masks

NASA Astrophysics Data System (ADS)

Choi, Won Tae; Yang, Xiaolong; Breedveld, Victor; Hess, Dennis W.

2017-12-01

Micropatterned surfaces with wettability contrast have attracted considerable attention due to potential applications in 2D microfluidics, bioassays, and water harvesting. A simple method to develop wettability contrast patterns on metallic surfaces by using a commercial marker is described. A marker-drawn ink pattern on a copper surface displays chemical resistance to an aqueous solution of sodium bicarbonate and ammonium persulfate, thereby enabling selective nanowire growth in areas where ink is absent. Subsequent ink removal by an organic solvent followed by fluorocarbon film deposition yields a stable hydrophobic/super-hydrophobic patterned copper surface. Using this approach, hydrophobic dot and line patterns were constructed. The adhesion force of water droplets to the dots was controlled by adjusting pattern size, thus enabling controlled droplet transfer between two surfaces. Anisotropy of water droplet adhesion to line patterns can serve as a basis for directional control of water droplet motion. This general approach has also been employed to generate wettability contrast on aluminum surfaces, thereby demonstrating versatility. Due to its simplicity, low cost, and virtual independence of solid surface material, ink marker pens can be employed to create wettability patterns for a variety of applications, in fields as diverse as biomedicine and energy.

Spatio-temporal patterns of mass fluxes of micropollutants in Swiss rivers of catchments with different land use

NASA Astrophysics Data System (ADS)

Stamm, Christian; van der Voet, Jürgen; Singer, Heinz

2010-05-01

It is known from many studies that a large number of micropollutants like pesticides, household products or pharmaceuticals can be found in water bodies. However, there is a general lack of systematic monitoring data that allow for distinguishing between possible sources, detecting temporal trends, or evaluating effects of possible mitigation measures. Including micropollutants in existing monitoring programs is not a trivial task for several reasons (e.g., sorption to sampling equipment, hydrolysis, detection limits etc.). Here, we present systematic concentration and load data for 12 substances (7 pesticides and/or biocides, 3 pharmaceuticals, and 2 anti-corrosives) obtained from a one-year sampling campaign within the "National Long-term Surveillance of Swiss Rivers" (NADUF) programme. Six (partially) nested sampling stations were selected to monitor these compounds in weekly or bi-weekly, flow-proportional samples over one year. Due to the high sensitivity of the LC-MSMS method all compounds could be quantified in almost all samples. Only at the reference site without any effluent from waste water treatment plants and hardly any arable farming, the concentrations were always below the limits of detection of a few ng/L. At all other sites, concentrations generally ranged between 10 and 200 ng/L. Only, the anticorrosive agent benzotriazole often exceeded 1000 ng/L. According to the use of the compounds, different temporal load patterns can be expected. In general, the data confirmed these patterns with almost constant loads of pharmaceuticals at most sites, increased herbicides loads during the periods of agricultural use and positive correlations with discharge year round for biocides used in material protection. However, at some sites the expectations were not met for all compounds. The pain-killer diclofenac for example showed strongly declining loads during the summer months at sites influenced by lake water. This compound is not stable in the epilimnion of lakes, where it has a residence time of several weeks, while it flows through the river system within a few days. This example illustrates how compound properties, season and spatial location may interact and control the occurrence of micropollutants in a stream. The spatial nesting of study catchments made it possible to check the data for plausibility and consistency: we present data on cumulative mass balances downstream and test whether the load development along the river network corresponds to the spatial distribution of possible compound sources (e.g., acreage of arable fields, number of inhabitants etc.). Overall, the data show that monitoring of micropollutants may be achieved even without changing an existing monitoring programme. However, given the generally low concentrations in the composite samples of the NADUF programme compounds with lower use and/or lower stability may fall below the limit of reliable quantification or even detection. A proper interpretation of the data relies on additional (spatio-temporal) information like land use data or precipitation patterns.

Archaeohydrological studies in the Sárvíz valley (Hungary) using high-resolution LiDAR data

NASA Astrophysics Data System (ADS)

Pacskó, Vivien; Székely, Balázs; Stibrányi, Máté; Koma, Zsófia

2015-04-01

The central area of the Pannonian basin encompasses mostly low-relief areas. Its south-western part, the southern Transdanubian hilly areas have characteristic NNW-SSE directional pattern. One of the largest valleys is a conspicuously straight valley section of the River Sárvíz between Székesfehérvár and Szekszárd. The river collects the waters of eastern Bakony Mountains takes its rise in Sárrét, in its natural condition originally a marshland, and flows into the river Sió towards the River Danube. The studied valley section is characterised by low relief, in the west it is bordered by a scarp with incised tributaries whereas the eastern side is less sharp. Its hydrological characteristics was artificially changed to due to river regulation in the 19th century in order to change the swampy character of the valley that was previously typical earlier (Sárvíz means muddy water). The area shows various settlement remains since the Neolithic, and characteristic spatial patterns have been found in ages of archaeological features and settlement sites, we assumed that the settlement pattern might have been influenced by the various water levels. To prove the changes in hydrological setting we can also use medieval written sources which makes us able to identify some of the former lakes and watercourse segments of the river at a surprising detail. Consequently, this research is aimed to detect the original features and the paleohydrological changes by collecting data on archaeological site locations and compare them to the fine elevation pattern of the sites. In order to derive the elevations of the identified sites LiDAR data acquisition has been carried out in the framework of the EUFAR project supported by the European Union. The weather conditions were not optimal for the measurements, so we paid special attention to the processing of the resulting point cloud to create a high-resolution, high-accuracy digital terrain model (DTM). The data have been processed with of OPALS software. We integrated the DTM and the known archaeological site locations in GIS system for qualitative and quantitative analysis. The processing aimed at discovering small-scale surface changes (at 5-10 cm scale) and its possible causes. The vertical clustering of the elevations of the sites above sea level show interesting patterns. The peaks of elevation histograms changes back and forth to lower and higher areas which shows that the settlement pattern has a history in elevations. Our interpretation is that this is due to the changes of the water levels in this low-relief areas. The water level changes may be due to several factors: (1) there may be long-term climatic changes influencing runoff and discharge; (2) the area is known to show geodynamic activity: there are at least two seismologically active zones (Berhida area and the Kapos line) that may cause tilting, slight tectonic uplift and/or subsidence so that the relief of the valley could have changed even at a historical timescale; (3) anthropogenic influence may also happened. There is a further possibility that a part of the observed variation in the elevation histograms is an artefact as not all the archaeological sites of a certain age have been found yet, so the histograms may also change later. Our current conclusion is that the elevation pattern change is largely real, it is related to hydrological changes, however, the cause of these hydrological cannot be separated yet. Our goal is to achieve an environmental historical reconstruction of the Valley of Sárvíz, and consequently to make methodological analysis with the LiDAR-based DTM to make predictions concerning the archaeological heritage. Owing to this interdisciplinary approach these data processing methods may contribute to reveal further archaeological sites. The data used were acquired in the framework of the EUFAR ARMSRACE project (to MS), the studies were carried out in project OTKA NK83400 financed by the Hungarian Scientific Research Fund. BS contributed as an Alexander von Humboldt Research Fellow.

Temporal patterns of the use of non-prescribed drugs.

PubMed

Sinnett, E R; Morris, J B

1977-12-01

Licit and illicit non-prescribed drugs, regardless of their classification, are used in a common temporal pattern with the possible exceptions of caffeine and cocaine. The temporal patterns of drug use are highly correlated with the nationwide temporal pattern of TV watching, suggesting a pleasure-oriented, recreational use. The peak times for substance use and abuse may have implications for the delivery of professional or paraprofessional services.

Principal factors of soil spatial heterogeneity and ecosystem services at the Central Chernozemic Region of Russia

NASA Astrophysics Data System (ADS)

Vasenev, Ivan; Valentini, Riccardo

2013-04-01

The essential spatial heterogeneity is mutual feature for most natural and man-changed soils at the Central Chernozemic Region of Russia which is not only one of the biggest «food baskets» in RF but very important regulator of ecosystem principal services at the European territory of Russia. The original spatial heterogeneity of dominated here forest-steppe and steppe Chernozems and the other soils has been further complicated by a specific land-use history and different-direction soil successions due to environmental changes and more than 1000-year history of human impacts. The carried out long-term researches of representative natural, rural and urban landscapes in Kursk, Orel, Tambov and Voronezh oblasts give us the regional multi-factorial matrix of elementary soil cover patterns (ESCP) with different land-use practices and history, soil-geomorphologic features, environmental and microclimate conditions. The validation and ranging of the limiting factors of ESCP regulation and development, ecosystem principal services, land functional qualities and agroecological state have been done for dominating and most dynamical components of ESCP regional-typological forms - with application of regional and local GIS, soil spatial patterns mapping, traditional regression kriging, correlation tree models. The outcomes of statistical modeling show the essential amplification of erosion, dehumification and CO2 emission, acidification and alkalization, disaggregation and overcompaction processes due to violation of agroecologically sound land-use systems and traditional balances of organic matter, nutrients, Ca and Na in agrolandscapes. Due to long-term intensive and out-of-balance land-use practices the famous Russian Chernozems begin to lose not only their unique natural features of (around 1 m of humus horizon, 4-6% of Corg and favorable agrophysical features), but traditional soil cover patterns, ecosystem services and agroecological functions. Key-site monitoring results and regional generalized data showed 1-1.5 % Corg lost during last 50 years period and active processes of CO2 emission and humus profile eluvial-illuvial redistribution too. Forest-steppe Chernozems are usually characterized by higher stability than steppe ones. The ratio between erosive and biological losses in humus supplies can be ten¬tatively estimated as fifty-fifty with strong spatial variability due to slope and land-use parameters. These processes have essentially different sets of environmental consequences and ecosystem services that we need to understand in frame of agroecological problems development prediction. A drop of Corg content below threshold "humus limiting content" values (3-4% of Corg) considerably reduces effectiveness of used fertilizers and possibility of sustainable agronomy here. This problem environmental and agroecological situation can be essentially improved by new federal law on environmentally friendly agriculture but it's draft is still in the process of deliberation. Quantitative analysis of principal ecosystem services, soil cover patterns and degradation processes in parameters of land qualities help us in developing different-scale projects for agricultural and urban land-use, taking into attention not only economical benefits but environmental functions too. The conceptions of ecosystem services and local land resource management are becoming more and more popular at the Central Chernozemic Region of Russia due to innovation application of basic agroecology, ecological monitoring and soil science achievements.

Entangled singularity patterns of photons in Ince-Gauss modes

NASA Astrophysics Data System (ADS)

Krenn, Mario; Fickler, Robert; Huber, Marcus; Lapkiewicz, Radek; Plick, William; Ramelow, Sven; Zeilinger, Anton

2013-01-01

Photons with complex spatial mode structures open up possibilities for new fundamental high-dimensional quantum experiments and for novel quantum information tasks. Here we show entanglement of photons with complex vortex and singularity patterns called Ince-Gauss modes. In these modes, the position and number of singularities vary depending on the mode parameters. We verify two-dimensional and three-dimensional entanglement of Ince-Gauss modes. By measuring one photon and thereby defining its singularity pattern, we nonlocally steer the singularity structure of its entangled partner, while the initial singularity structure of the photons is undefined. In addition we measure an Ince-Gauss specific quantum-correlation function with possible use in future quantum communication protocols.

The orbital record in stratigraphy

NASA Technical Reports Server (NTRS)

Fischer, Alfred G.

1992-01-01

Orbital signals are being discovered in pre-Pleistocene sediments. Due to their hierarchical nature these cycle patterns are complex, and the imprecision of geochronology generally makes the assignment of stratigraphic cycles to specific orbital cycles uncertain, but in sequences such as the limnic Newark Group under study by Olsen and pelagic Cretaceous sequence worked on by our Italo-American group the relative frequencies yield a definitive match to the Milankovitch hierarchy. Due to the multiple ways in which climate impinges on depositional systems, the orbital signals are recorded in a multiplicity of parameters, and affect different sedimentary facies in different ways. In platform carbonates, for example, the chief effect is via sea-level variations (possibly tied to fluctuating ice volume), resulting in cycles of emergence and submergence. In limnic systems it finds its most dramatic expression in alternations of lake and playa conditions. Biogenic pelagic oozes such as chalks and the limestones derived from them display variations in the carbonate supplied by planktonic organisms such as coccolithophores and foraminifera, and also record variations in the aeration of bottom waters. Whereas early studies of stratigraphic cyclicity relied mainly on bedding variations visible in the field, present studies are supplementing these with instrumental scans of geochemical, paleontological, and geophysical parameters which yield quantitative curves amenable to time-series analysis; such analysis is, however, limited by problems of distorted time-scales. My own work has been largely concentrated on pelagic systems. In these, the sensitivity of pelagic organisms to climatic-oceanic changes, combined with the sensitivity of botton life to changes in oxygen availability (commonly much more restricted in the Past than now) has left cyclic patterns related to orbital forcing. These systems are further attractive because (1) they tend to offer depositional continuity, and (2) presence of abundant microfossils yields close ties to geochronology. A tantalizing possibility that stratigraphy may yield a record of orbital signals unrelated to climate has turned up in magnetic studies of our Cretaceous core. Magnetic secular variations here carry a strong 39 ka periodicity, corresponding to the theoretical obliquity period of that time - Does the obliquity cycle perhaps have some direct influence on the magnetic field?

Metals accumulations during thermal processing of sewage sludge - characterization of bottom ash and air pollution control (APC) residues

NASA Astrophysics Data System (ADS)

Kasina, Monika; Kowalski, Piotr R.; Michalik, Marek

2016-04-01

Due to increasing mass of sewage sludge, problems in its management have appeared. Over years sewage sludge was landfilled, however due to EU directives concerning environmental issues this option is no longer possible. This type of material is considered hazardous due to highly concentrated metals and harmful elements, toxic organic substances and biological components (e.g. parasites, microbes). Currently in Europe, incineration is considered to be the most reasonable method for sewage sludge treatment. As a result of sludge incineration significant amount of energy is recovered due to high calorific value of sewage sludge but bottom ash and APC residues are being produced. In this study we show the preliminary results of chemical and mineral analyses of both bottom ash and APC residues produced in fluidized bed boiler in sewage sludge incineration plant in Poland, with a special emphasis on metals which, as a part of incombustible fraction can accumulate in the residual materials after thermal processing. The bottom ash was a SiO2-P2O5-Fe2O3-CaO-Al2O3 dominated material. Main mineral phases identified in X-ray diffraction patterns were: quartz, feldspar, hematite, and phosphates (apatite and scholzite). The bottom ash was characterized by high content of Zn - 4472 mg kg-1, Cu - 665.5 mg kg-1, Pb - 138 mg kg-1, Ni - 119.5 mg kg-1, and interestingly high content of Au - 0.858 mg kg-1 The APC residues composition was dominated by soluble phases which represent more than 90% of the material. The XRD patterns indicated thenardite, halite, anhydrite, calcite and apatite as main mineral phases. The removal of soluble phases by dissolution in deionised water caused a significant mass reduction (ca. 3% of material remained on the filters). Calcite, apatite and quartz were main identified phases. The content of metals in insoluble material is relatively high: Zn - 6326 mg kg-1, Pb - 514.3 mg kg-1, Cu - 476.6 mg kg-1, Ni - 43.3 mg kg-1. The content of Cd, As, Se and Hg was noted also what can be a reason of potential environmental concerns. A significant reduction of sludge volume after incineration causes concentration of numerous elements in both types of residues. The removal of soluble fraction from APC residues caused almost a 30-fold additional concentration of elements what makes this material interesting in terms of metals recovery. A detailed identification of metals occurrences and their distribution within mineral phases will be of a great importance in determination of possibilities of their recovery. Acknowledgment: The study was supported by Polish Nacional Science Centre NCN grant No UMO-2014/15/B/ST10/04171

Sleep patterns as predictors for disability pension due to low back diagnoses: a 23-year longitudinal study of Finnish twins.

PubMed

Ropponen, Annina; Silventoinen, Karri; Hublin, Christer; Svedberg, Pia; Koskenvuo, Markku; Kaprio, Jaakko

2013-06-01

Impaired sleep patterns are known to be associated with many chronic conditions and ultimately they may lead to permanent work incapacity. Less is known about the associations between sleep patterns and cause-specific disability pensions, such as low back diagnoses, or whether familial factors (genetics and family environment) can affect the associations. The objective of this study was to investigate sleep patterns as predictors of disability pension due to low back diagnoses with a 23-year follow-up. A prospective cohort study with comprehensive mailed questionnaires about sleep patterns, e.g., quality and length of sleep in 1975 and 1981. Follow-up from the national disability pension register data until 2004. Not applicable. There were 18,979 individuals (7,722 complete twin pairs) born before 1958. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (95% CI). Disability pension due to low back diagnoses had been granted to 467 individuals during the follow-up. Sleeping moderately well (HR 1.25; 95% CI 1.02, 1.53), or fairly poorly/poorly (HR 2.05; 95% CI 1.53, 2.73) at baseline predicted a significantly higher risk for disability pension. Stable patterns of sleeping either fairly well (HR 1.29; 95% CI 1.01, 1.64), or stably fairly poorly/poorly (HR 2.29; 95% CI 1.49, 3.52) between 1975 and 1981 were associated with a higher risk as compared to a stable pattern of sleeping well. Furthermore, a decrease in quality of sleep from 1975 to 1981 was associated (HR 1.34; 95% CI 1.03, 1.76) with an increased risk of disability pension. Sleep quality and changes in sleep quality appear to be early predictors for disability pension due to low back diagnoses independently from other confounding factors.

78 FR 43228 - Agency Information Collection Activities: Submission to OMB for Reinstatement, With Change, of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

... patterns and enforcing anti-discrimination statutes. The information collection will assist NCUA to ensure... assist in identifying possible discriminatory lending patterns and enforcing anti-discrimination statutes...

The necessity of DNA taxonomy to reveal cryptic diversity and spatial distribution of meiofauna, with a focus on Nemertea.

PubMed

Leasi, Francesca; Norenburg, Jon L

2014-01-01

Meiofauna represent one of the most abundant and diverse communities in marine benthic ecosystems. However, an accurate assessment of diversity at the level of species has been and remains challenging for these microscopic organisms. Therefore, for many taxa, especially the soft body forms such as nemerteans, which often lack clear diagnostic morphological traits, DNA taxonomy is an effective means to assess species diversity. Morphological taxonomy of Nemertea is well documented as complicated by scarcity of unambiguous character states and compromised by diagnoses of a majority of species (and higher clades) being inadequate or based on ambiguous characters and character states. Therefore, recent studies have advocated for the primacy of molecular tools to solve the taxonomy of this group. DNA taxonomy uncovers possible hidden cryptic species, provides a coherent means to systematize taxa in definite clades, and also reveals possible biogeographic patterns. Here, we analyze diversity of nemertean species by considering the barcode region of the mitochondrial gene Cytochrome Oxidase subunit I (COI) and different species delineation approaches in order to infer evolutionarily significant units. In the aim to uncover actual diversity of meiofaunal nemerteans across different sites in Central America, COI sequences were obtained for specimens assigned here to the genera Cephalothrix, Ototyphlonemertes, and Tetrastemma-like worms, each commonly encountered in our sampling. Additional genetic, taxonomic, and geographic data of other specimens belonging to these genera were added from GenBank. Results are consistent across different DNA taxonomy approaches, and revealed (i) the presence of several hidden cryptic species and (ii) numerous potential misidentifications due to traditional taxonomy. (iii) We additionally test a possible biogeographic pattern of taxonomic units revealed by this study, and, except for a few cases, the putative species seem not to be widely distributed, in contrast to what traditional taxonomy would suggest for the recognized morphotypes.

Placement-aware decomposition of a digital standard cells library for double patterning lithography

NASA Astrophysics Data System (ADS)

Wassal, Amr G.; Sharaf, Heba; Hammouda, Sherif

2012-11-01

To continue scaling the circuit features down, Double Patterning (DP) technology is needed in 22nm technologies and lower. DP requires decomposing the layout features into two masks for pitch relaxation, such that the spacing between any two features on each mask is greater than the minimum allowed mask spacing. The relaxed pitches of each mask are then processed on two separate exposure steps. In many cases, post-layout decomposition fails to decompose the layout into two masks due to the presence of conflicts. Post-layout decomposition of a standard cells block can result in native conflicts inside the cells (internal conflict), or native conflicts on the boundary between two cells (boundary conflict). Resolving native conflicts requires a redesign and/or multiple iterations for the placement and routing phases to get a clean decomposition. Therefore, DP compliance must be considered in earlier phases, before getting the final placed cell block. The main focus of this paper is generating a library of decomposed standard cells to be used in a DP-aware placer. This library should contain all possible decompositions for each standard cell, i.e., these decompositions consider all possible combinations of boundary conditions. However, the large number of combinations of boundary conditions for each standard cell will significantly increase the processing time and effort required to obtain all possible decompositions. Therefore, an efficient methodology is required to reduce this large number of combinations. In this paper, three different reduction methodologies are proposed to reduce the number of different combinations processed to get the decomposed library. Experimental results show a significant reduction in the number of combinations and decompositions needed for the library processing. To generate and verify the proposed flow and methodologies, a prototype for a placement-aware DP-ready cell-library is developed with an optimized number of cell views.

A non-invasive geometric morphometrics method for exploring variation in dorsal head shape in urodeles: sexual dimorphism and geographic variation in Salamandra salamandra.

PubMed

Alarcón-Ríos, Lucía; Velo-Antón, Guillermo; Kaliontzopoulou, Antigoni

2017-04-01

The study of morphological variation among and within taxa can shed light on the evolution of phenotypic diversification. In the case of urodeles, the dorso-ventral view of the head captures most of the ontogenetic and evolutionary variation of the entire head, which is a structure with a high potential for being a target of selection due to its relevance in ecological and social functions. Here, we describe a non-invasive procedure of geometric morphometrics for exploring morphological variation in the external dorso-ventral view of urodeles' head. To explore the accuracy of the method and its potential for describing morphological patterns we applied it to two populations of Salamandra salamandra gallaica from NW Iberia. Using landmark-based geometric morphometrics, we detected differences in head shape between populations and sexes, and an allometric relationship between shape and size. We also determined that not all differences in head shape are due to size variation, suggesting intrinsic shape differences across sexes and populations. These morphological patterns had not been previously explored in S. salamandra, despite the high levels of intraspecific diversity within this species. The methodological procedure presented here allows to detect shape variation at a very fine scale, and solves the drawbacks of using cranial samples, thus increasing the possibilities of using collection specimens and alive animals for exploring dorsal head shape variation and its evolutionary and ecological implications in urodeles. J. Morphol. 278:475-485, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Endogenous circadian rhythm in vasovagal response to head-up tilt

PubMed Central

Hu, Kun; Scheer, Frank AJL; Laker, Michael; Smales, Carolina; Shea, Steven A

2011-01-01

Background The incidence of syncope exhibits a daily pattern with more occurrences in the morning, possibly due to influences from the endogenous circadian system and/or the daily pattern of behavioral/emotional stimuli. This study tested the hypothesis that the circadian system modulates cardiovascular responses to postural stress, leading to increased susceptibility to syncope at specific times of day. Methods and Results Twelve subjects underwent a 13-day in-laboratory protocol, in which subjects’ sleep-wake cycles were adjusted to 20 hours for 12 cycles. A 15-minute title-table test (60° head-up) was performed ~4.5 hours after scheduled awakening in each cycle so that twelve tests in each subject were distributed evenly across the circadian cycle. Out of 144 tests, signs/symptoms of presyncope were observed in 21 tests in 6 subjects. These presyncope events displayed a clear circadian rhythm (P=0.028) with 17 cases (81%) in the circadian phase range corresponding to ~22:30-10:30 (4.25 times of the probability from the other half of the circadian cycle). Significant circadian rhythms were also observed in hemodynamic and autonomic function markers (blood pressure, heart rate, epinephrine, norepinephrine, and indices of cardiac vagal tone) that may underlie the circadian rhythm of presyncope susceptibility. Conclusion The circadian system affects cardiovascular responses to postural stressors resulting in greater susceptibility to presyncope during the biological night. This finding suggests that night-shift workers and people with disrupted sleep at night may have great risk of syncope due to their exposure to postural stressors during the biological night. PMID:21339480

Phenotypic plasticity of post-fire activity and thermal biology of a free-ranging small mammal.

PubMed

Stawski, Clare; Körtner, Gerhard; Nowack, Julia; Geiser, Fritz

2016-05-15

Ecosystems can change rapidly and sometimes irreversibly due to a number of anthropogenic and natural factors, such as deforestation and fire. How individual animals exposed to such changes respond behaviourally and physiologically is poorly understood. We quantified the phenotypic plasticity of activity patterns and torpor use - a highly efficient energy conservation mechanism - in brown antechinus (Antechinus stuartii), a small Australian marsupial mammal. We compared groups in densely vegetated forest areas (pre-fire and control) with a group in a burned, open habitat (post-fire). Activity and torpor patterns differed among groups and sexes. Females in the post-fire group spent significantly less time active than the other groups, both during the day and night. However, in males only daytime activity declined in the post-fire group, although overall activity was also reduced on cold days in males for all groups. The reduction in total or diurnal activity in the post-fire group was made energetically possible by a ~3.4-fold and ~2.2-fold increase in the proportion of time females and males, respectively, used torpor in comparison to that in the pre-fire and control groups. Overall, likely due to reproductive needs, torpor was more pronounced in females than in males, but low ambient temperatures increased torpor bout duration in both sexes. Importantly, for both male and female antechinus and likely other small mammals, predator avoidance and energy conservation - achieved by reduced activity and increased torpor use - appear to be vital for post-fire survival where ground cover and refuges have been obliterated. Copyright © 2016 Elsevier Inc. All rights reserved.

Low-frequency climate anomalies, changes in synoptic scale circulation patterns and statistics of extreme events over south-east Poland during the Last Millennium

NASA Astrophysics Data System (ADS)

Slawinska, J. M.; Bartoszek, K.; Gabriel, C. J.

2016-12-01

Long-term predictions of changes in extreme event frequency are of utmost importance due to their high societal and economic impact. Yet, current projections are of limited skills as they rely on satellite records that are relatively short compared to the timescale of interest, and also due to the presence of a significant anthropogenic trend superimposed onto other low-frequency variabilities. Novel simulations of past climates provide unique opportunity to separate external perturbations from internal climate anomalies and to attribute the latter to systematic changes in different types of synoptic scale circulation and distributions of high-frequency events. Here we study such changes by employing the Last Millennium Ensemble of climate simulations carried out with the Community Earth System Model (CESM) at the U.S. National Center for Atmospheric Research, focusing in particular on decadal changes in frequency of extreme precipitation events over south-east Poland. We analyze low-frequency modulations of dominant patterns of synoptic scale circulations over Europe and their dependence on the Atlantic Meridional Overturning Circulation, along with their coupling with the North Atlantic Oscillation. Moreover, we examine whether some decades of persistently anomalous statistics of extreme events can be attributed to externally forced (e.g., via volcanic eruptions) perturbations of the North Atlantic climate. In the end, we discuss the possible linkages and physical mechanisms connecting volcanic eruptions, low-frequency variabilities of North Atlantic climate and changes in statistics of high impact weather, and compare briefly our results with some historical and paleontological records.

Monitoring millimeter wave stray radiation during ECRH operation at ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Schubert, M.; Honecker, F.; Monaco, F.; Schmid-Lorch, D.; Schütz, H.; Stober, J.; Wagner, D.

2012-09-01

Due to imperfection of the single path absorption, ECRH at ASDEX Upgrade (AUG) is always accompanied by stray radiation in the vacuum vessel. New ECRH scenarios with O2 and X3 heating schemes extend the operational space, but they have also the potential to increase the level of stray radiation. There are hazards for invessel components. Damage on electric cables has already been encountered. It is therefore necessary to monitor and control the ECRH with respect to the stray radiation level. At AUG a system of Sniffer antennas equipped with microwave detection diodes is installed. The system is part of the ECRH interlock circuit. We notice, however, that during plasma operation the variations of the Sniffer antenna signal are very large. In laboratory measurements we see variations of up to 20 dB in the directional sensitivity and we conclude that an interference pattern is formed inside the copper sphere of the antenna. When ECRH is in plasma operation at AUG, the plasma is acting as a phase and mode mixer for the millimeter waves and thus the interference pattern inside the sphere changes with the characteristic time of the plasma dynamics. In order to overcome the difficulty of a calibrated measurement of the average stray radiation level, we installed bolometer and pyroelectric detectors, which intrinsically average over interference structures due to their large active area. The bolometer provides a robust calibration but with moderate temporal resolution. The pyroelectric detector provides high sensitivity and a good temporal resolution, but it raises issues of possible signal drifts in long pulses.

Blood Pressure Levels and Mortality Risk among Hemodialysis Patients: Results from the Dialysis Outcomes and Practice Patterns Study

PubMed Central

Robinson, Bruce M.; Tong, Lin; Zhang, Jinyao; Wolfe, Robert A.; Goodkin, David A.; Greenwood, Roger N.; Kerr, Peter G.; Morgenstern, Hal; Li, Yun; Pisoni, Ronald L.; Saran, Rajiv; Tentori, Francesca; Akizawa, Tadao; Fukuhara, Shunichi; Port, Friedrich K.

2014-01-01

KDOQI practice guidelines recommend pre-dialysis blood pressure (BP) <140/90 mm Hg. However, most prior hemodialysis studies found elevated mortality with low, not high, systolic blood pressure (SBP), possibly due to unmeasured confounders affecting BP and mortality such as severity of comorbidities. To lessen this bias, we analyzed facility-level BP practices, relating patient-level survival to the fraction of patients in BP categories at each dialysis facility in Cox regression models adjusted for patient and facility characteristics. Analyses included 24,525 patients in the Dialysis Outcomes and Practice Patterns Study. Compared with pre-dialysis SBP 130–159 mm Hg, mortality was 13% higher in facilities with 20% more patients at SBP 110–129 mm Hg and 16% higher in facilities with 20% more patients at SBP ≥160 mm Hg. For patient-level SBP, mortality was elevated at low (<130 mm Hg), not high (up to ≥180 mm Hg) SBP. For pre-dialysis diastolic BP, mortality was lowest at 60–99 mm Hg, a wide range suggesting less chance to improve outcomes. Higher mortality at SBP <130 mm Hg is consistent with prior studies and may be due to excessive BP-lowering during dialysis. The lowest risk facility SBP range of 130–159 mm Hg indicates this range may be optimal, but may have been influenced by unmeasured facility practices. While additional study is needed, the findings contrast with KDOQI BP targets, and provide guidance on optimal BP range in absence of definitive clinical trial data. PMID:22718187

Transferrin hypoglycosylation in hereditary fructose intolerance: using the clues and avoiding the pitfalls.

PubMed

Adamowicz, M; Płoski, R; Rokicki, D; Morava, E; Gizewska, M; Mierzewska, H; Pollak, A; Lefeber, D J; Wevers, R A; Pronicka, E

2007-06-01

Hereditary fructose intolerance (HFI) is caused by a deficiency of aldolase B due to mutations of the ALDOB gene. The disease poses diagnostic problems because of unspecific clinical manifestations. We report three cases of HFI all of whom had a chronic disease with neurological, nephrological or gastroenterological symptoms, whereas nutritional fructose intolerance, the pathognomonic sign of HFI, was apparent only in retrospect. In all patients a hypoglycosylated pattern of transferrin isoforms was found but was misinterpreted as a sign of CDG Ix. The correct diagnosis was achieved with marked delay (26, 36 and 24 months, respectively) by sequencing of the ALDOB gene two common mutations were identified on both alleles or on one (A150P/A175D, A150P/-, and A150P/A175D). The diagnosis was further supported by normalization of transferrin isoforms on a fructose-free diet. Data available in two patients showed that following the fructose restriction the type I pattern of carbohydrate-deficient transferrin detectable on fructose-containing diet disappeared after 3-4 weeks. These cases illustrate that in the first years of life HFI may show misleading variability in clinical presentation and that protein glycosylation analysis such as transferrin isofocusing may give important diagnostic clues. However, care should be taken not to misinterpret the abnormal results as CDG Ix as well as to remember that a normal profile does not exclude HFI due to the possibility of spontaneous fructose restriction in the diet. The presented data also emphasize the usefulness of ALDOB mutation screening for diagnosis of HFI.

Coccolithophore diversity and dynamics at a coastal site in the Gulf of Trieste (northern Adriatic Sea)

NASA Astrophysics Data System (ADS)

Cerino, Federica; Malinverno, Elisa; Fornasaro, Daniela; Kralj, Martina; Cabrini, Marina

2017-09-01

Two years-data (May 2011-February 2013) obtained from a monthly sampling carried out at the coastal long term Ecological Research station C1-LTER in the Gulf of Trieste (northern Adriatic Sea) were analysed to describe the seasonal dynamics and diversity of coccolithophore assemblages and to assess their relationship with environmental forcing. Coccolithophores represented 10.7% of the total Utermöhl phytoplankton that were mainly dominated by small (<10 μm) flagellates and diatoms (62.2% and 24.8% of total abundances, respectively). Coccolithophore abundances obtained by polarized light microscopy analysis ranged from 0.2 to 35.3 · 104 coccospheres L-1 with a mean value of 5.2 · 104 coccospheres L-1. A marked seasonal pattern was observed with a main peak in December-February (2.5-31.5 · 104 coccospheres L-1), in correspondence of the winter mixing, mainly due to Emiliania huxleyi, and a secondary peak in May-June (0.7-15.0 · 104 coccospheres L-1), coinciding with the increase of the light intensity and the beginning of the seasonal stratification, dominated by holococcolithophores and small Syracosphaera species. The most abundant taxa were E. huxleyi and holococcolithophores, followed by Acanthoica quattrospina, Syracosphaera species and other minor species. Statistical analyses recognized four distinct groups, corresponding to seasonal variations of environmental conditions. Considering the two years, some species displayed a recurrent seasonal pattern highlighting possible species-specific ecological requirements, while others showed an interannual variability probably due to local factors.

Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review

PubMed Central

Ng, Ka-Yan; Yu, Yee-Man; Ng, Bacon Fung-Leung; Ziea, Eric Tat-Chi

2015-01-01

Traditional Chinese medicine (TCM) treatments are often prescribed based on individuals' pattern diagnoses. A systematic review of randomized controlled trials in Chinese and English literatures on TCM pattern-based treatment for depression has therefore been conducted. A total of 61 studies, 2504 subjects, and 27 TCM patterns were included. Due to the large variation of TCM pattern among participants, we only analyzed the top four commonly studied TCM patterns: liver qi depression, liver depression and spleen deficiency, dual deficiency of the heart, and spleen and liver depression and qi stagnation. We found that Xiaoyao decoction was the most frequently used herbal formula for the treatment of liver qi depression and liver depression with spleen deficiency, while Chaihu Shugan decoction was often used for liver depression and qi stagnation. Bai Shao (Paeonia lactiflora Pall.) and Chai Hu (Bupleurum chinense DC.) were commonly used across different TCM patterns regardless of the prescribed Chinese herbal formulas. The rationale underlying herb selection was seldom provided. Due to the limited number of studies on TCM pattern-based treatment of depression and their low methodological quality, we are unable to draw any conclusion regarding which herbal formulas have higher efficacy and which TCM patterns respond better to CHM. PMID:26180532

Heteroassociative storage of hippocampal pattern sequences in the CA3 subregion

PubMed Central

Recio, Renan S.; Reyes, Marcelo B.

2018-01-01

Background Recent research suggests that the CA3 subregion of the hippocampus has properties of both autoassociative network, due to its ability to complete partial cues, tolerate noise, and store associations between memories, and heteroassociative one, due to its ability to store and retrieve sequences of patterns. Although there are several computational models of the CA3 as an autoassociative network, more detailed evaluations of its heteroassociative properties are missing. Methods We developed a model of the CA3 subregion containing 10,000 integrate-and-fire neurons with both recurrent excitatory and inhibitory connections, and which exhibits coupled oscillations in the gamma and theta ranges. We stored thousands of pattern sequences using a heteroassociative learning rule with competitive synaptic scaling. Results We showed that a purely heteroassociative network model can (i) retrieve pattern sequences from partial cues with external noise and incomplete connectivity, (ii) achieve homeostasis regarding the number of connections per neuron when many patterns are stored when using synaptic scaling, (iii) continuously update the set of retrievable patterns, guaranteeing that the last stored patterns can be retrieved and older ones can be forgotten. Discussion Heteroassociative networks with synaptic scaling rules seem sufficient to achieve many desirable features regarding connectivity homeostasis, pattern sequence retrieval, noise tolerance and updating of the set of retrievable patterns. PMID:29312826

Detection and characterization of defects in moving parts of wind turbines

NASA Astrophysics Data System (ADS)

Forero, E.; Tibaduiza, D.; Anaya, M.; Castro, R.

2016-07-01

The detection, localization and characterization of defects in a material or a part that conform a structure is possible by using the transmission and reception of ultrasonic signals. Different strategies are used to achieve extract information from the part under evaluation. For this, it is then possible to use a distributed sensors arrays on the surface of the material and using scanning techniques such as are A-scan or B-scan, where it is possible to increase the level of detail regarding location, orientation and size of defects found, according to the strategy used. However, the systems and inspection techniques are often limited by the geometries and access to different types of structures. Due to these reasons, the acquisition of the returned signals, for identification and attenuation time, can suppress valuable information for accurate characterization of imperfections found in shape and location. In this paper, the use of spectral analysis of the collected signals is proposed as a tool for detection and characterization of defects in a structure. This analysis allows to determining the power distribution in a frequency range. This methodology is useful in non-destructive evaluation when it is not possible to have full access to the structure under inspection. In this case it is applied on a wind turbine operating to make the study of different echoes captured according to the geometry of the part and comparing said conducting analysis with previously established patterns of shapes, orientations, and sizes of defects found.

A likelihood-based approach to identifying contaminated food products using sales data: performance and challenges.

PubMed

Kaufman, James; Lessler, Justin; Harry, April; Edlund, Stefan; Hu, Kun; Douglas, Judith; Thoens, Christian; Appel, Bernd; Käsbohrer, Annemarie; Filter, Matthias

2014-07-01

Foodborne disease outbreaks of recent years demonstrate that due to increasingly interconnected supply chains these type of crisis situations have the potential to affect thousands of people, leading to significant healthcare costs, loss of revenue for food companies, and--in the worst cases--death. When a disease outbreak is detected, identifying the contaminated food quickly is vital to minimize suffering and limit economic losses. Here we present a likelihood-based approach that has the potential to accelerate the time needed to identify possibly contaminated food products, which is based on exploitation of food products sales data and the distribution of foodborne illness case reports. Using a real world food sales data set and artificially generated outbreak scenarios, we show that this method performs very well for contamination scenarios originating from a single "guilty" food product. As it is neither always possible nor necessary to identify the single offending product, the method has been extended such that it can be used as a binary classifier. With this extension it is possible to generate a set of potentially "guilty" products that contains the real outbreak source with very high accuracy. Furthermore we explore the patterns of food distributions that lead to "hard-to-identify" foods, the possibility of identifying these food groups a priori, and the extent to which the likelihood-based method can be used to quantify uncertainty. We find that high spatial correlation of sales data between products may be a useful indicator for "hard-to-identify" products.

Generalizability of dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk

USDA-ARS?s Scientific Manuscript database

Epidemiology of dietary components and disease risk limits interpretability due to potential residual confounding by correlated dietary components. Dietary pattern analyses by factor analysis or partial least squares may overcome this limitation. To examine confounding by dietary pattern as well as ...

Confounding by dietary pattern of the inverse association between alcohol consumption and type 2 diabetes risk

USDA-ARS?s Scientific Manuscript database

Epidemiology of dietary components and disease risk limits interpretability due to potential residual confounding by correlated dietary components. Dietary pattern analyses by factor analysis or partial least squares may overcome the limitation. To examine confounding by dietary pattern as well as ...

Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk

USDA-ARS?s Scientific Manuscript database

Epidemiology of dietary components and disease risk limits interpretability due to potential residual confounding by correlated dietary components. Dietary pattern analyses by factor analysis or partial least squares may overcome this limitation. To examine confounding by dietary pattern as well as ...