Science.gov

Sample records for pc regulatory tracking

  1. Emissions tracking system (ETS-PC) software

    SciTech Connect

    Weatherbee, J. Jr.; Kress, T.

    1997-12-31

    The U.S. EPA Acid Rain Division developed and is maintaining the Emissions Tracking System (ETS) to receive, store and analyze data from continuous emissions monitors (CEMs) submitted by utilities affected by the 1990 Clean Air Act. This paper will describe ETS-PC, a PC application developed by EPA to assist utilities in analyzing and submitting emission data files each quarter. ETS-PC includes quality assurance software which helps utilities identify possible errors in their quarterly data files (QDFs) prior to submission. It also includes communications software which allows utilities to transfer QDFs via modem directly to the EPA mainframe computer located in Research Triangle Park, NC. After a file is transferred, users are provided with immediate feedback from the mainframe in the form of a file transfer receipt and summary.

  2. 36. View of preset counter (PC) console and tracking console ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. View of preset counter (PC) console and tracking console on right, located in MWOC facility in transmitter building no. 102. - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

  3. New conductive copolymer membranes via track-etched PC templates for biological media ultra-filtration

    NASA Astrophysics Data System (ADS)

    Berthelot, T.; Baudin, C.; Balanzat, E.; Clochard, M.-C.

    2007-12-01

    New microstructurated copolymer membranes have been synthesized using a track-etched polycarbonate (PC) matrix. These membranes proved to be an important device in the field of ultra-filtration and synthetic membranes. These novel structures were obtained by irradiating at various angles (+30°, -30°). Such architecture is expected to improve not only the exchange properties but also, the behaviour under high flow pressure during their use as nanofiltration membranes. Membrane functionalization was performed with an amino acid as a simple biological model. Transmission and ATR-FTIR spectroscopies show that the doping state of copolymer dramatically influences the amino acid coupling rate. UV-vis spectroscopy indicates that the copolymer may be self-doped.

  4. microRNA regulatory mechanism by which PLLA aligned nanofibers influence PC12 cell differentiation

    NASA Astrophysics Data System (ADS)

    Yu, Yadong; Lü, Xiaoying; Ding, Fei

    2015-08-01

    Objective. Aligned nanofibers (AFs) are regarded as promising biomaterials in nerve tissue engineering. However, a full understanding of the biocompatibility of AFs at the molecular level is still challenging. Therefore, the present study focused on identifying the microRNA (miRNA)-mediated regulatory mechanism by which poly-L-lactic acid (PLLA) AFs influence PC12 cell differentiation. Approach. Firstly, the effects of PLLA random nanofibers (RFs)/AFs and PLLA films (control) on the biological responses of PC12 cells that are associated with neuronal differentiation were examined. Then, SOLiD sequencing and cDNA microarray were employed to profile the expressions of miRNAs and mRNAs. The target genes of the misregulated miRNAs were predicted and compared with the mRNA profile data. Functions of the matched target genes (the intersection between the predicted target genes and the experimentally-determined, misregulated genes) were analyzed. Main results. The results revealed that neurites spread in various directions in control and RF groups. In the AF group, most neurites extended in parallel with each other. The glucose consumption and lactic acid production in the RF and AF groups were higher than those in the control group. Compared with the control group, 42 and 94 miRNAs were significantly dysregulated in the RF and AF groups, respectively. By comparing the predicted target genes with the mRNA profile data, five and 87 matched target genes were found in the RF and AF groups, respectively. Three of the matched target genes in the AF group were found to be associated with neuronal differentiation, whereas none had this association in the RF group. The PLLA AFs induced the dysregulation of miRNAs that regulate many biological functions, including axonal guidance, lipid metabolism and long-term potentiation. In particular, two miRNA-matched target gene-biological function modules associated with neuronal differentiation were identified as follows: (1) miR-23b, mi

  5. PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum.

    PubMed

    Domínguez-Santos, Rebeca; García-Estrada, Carlos; Kosalková, Katarina; Prieto, Carlos; Santamarta, Irene; Martín, Juan-Francisco

    2015-08-01

    Penicillin biosynthesis in Penicillium chrysogenum (re-identified as Penicillium rubens) is a good example of a biological process subjected to complex global regulatory networks and serves as a model to study fungal secondary metabolism. The winged-helix family of transcription factors recently described, which includes the forkhead type of proteins, is a key type of regulatory proteins involved in this process. In yeasts and humans, forkhead transcription factors are involved in different processes (cell cycle regulation, cell death control, pre-mRNA processing and morphogenesis); one member of this family of proteins has been identified in the P. chrysogenum genome (Pc18g00430). In this work, we have characterized this novel transcription factor (named PcFKH1) by generating knock-down mutants and overexpression strains. Results clearly indicate that PcFKH1 positively controls antibiotic biosynthesis through the specific interaction with the promoter region of the penDE gene, thus regulating penDE mRNA levels. PcFKH1 also binds to the pcbC promoter, but with low affinity. In addition, it also controls other ancillary genes of the penicillin biosynthetic process, such as phlA (encoding phenylacetyl CoA ligase) and ppt (encoding phosphopantetheinyl transferase). PcFKH1 also plays a role in conidiation and spore pigmentation, but it does not seem to be involved in hyphal morphology or cell division in the improved laboratory reference strain Wisconsin 54-1255. A genome-wide analysis of processes putatively coregulated by PcFKH1 and PcRFX1 (another winged-helix transcription factor) in P. chrysogenum provided evidence of the global effect of these transcription factors in P. chrysogenum metabolism.

  6. Real Time Metastatic Route Tracking of Orthotopic PC-3-GFP Human Prostate Cancer Using Intravital Imaging.

    PubMed

    Zhang, Yong; Wang, Xiaoen; Hoffman, Robert M; Seki, Naohiko

    2016-04-01

    The cellular basis of metastasis is poorly understood. An important step to understanding this process is to be able to visualize the routes by which cancer cells migrate from the primary tumor to various distant sites to eventually form metastasis. Our laboratory previously developed single-cell in vivo imaging using fluorescent proteins to label cancer cells. In the present study, using PC-3 human prostate cancer cells labeled with green fluorescent protein (GFP) and orthotopic tumor transplantation, we have imaged in live mice various highly diverse routes by which PC-3 cells metastasize superiorly and inferiorly to distant sites, including in the portal area, stomach area, and urogenital system. Imaging began at day 9, at which time distant metastasis had already occurred, and increased at each imaging point at days 10, 13, 14, and 16. Metastatic cells were observed migrating superiorly and inferiorly from the primary tumor as well as in lymphatic channels and trafficking in various organ systems demonstrating that PC-3 has multiple metastatic routes similar to hormone-independent advanced-stage prostate cancer in the clinic. PMID:26515240

  7. Development of the Emission Measurement and Information Tracking System (EMITS) for regulatory analysis

    SciTech Connect

    McCormack, C.E.; Dorenkamp, L.D.

    1994-10-01

    With the constant implementation of complex and restrictive state and federal clean air laws, a facility must have a comprehensive understanding of the types and amount of emissions associated with the facility`s operations. Knowledge of the facility`s emissions is essential to assess the operational impacts of current and upcoming legislation. Lawrence Livermore National Laboratory (LLNL), located in California, is regulated by federal, state, and local air quality agencies. Of most concern to the facility is California`s Assembly Bill 2588 (also known as the {open_quotes}Air Toxics Hot Spots{close_quotes} program) and the federal Title III, Title V, and Title VI provisions of the Clean Air Act as amended in 1990. Because of the complex regulatory requirements, LLNL needed a system to calculate and classify air emissions by each applicable regulatory program. This paper outlines the development of LLNL`s comprehensive emissions inventory known as the Emissions Measurement and Information Tracking System (EMITS).

  8. Constitutive Activation of an Anthocyanin Regulatory Gene PcMYB10.6 Is Related to Red Coloration in Purple-Foliage Plum.

    PubMed

    Gu, Chao; Liao, Liao; Zhou, Hui; Wang, Lu; Deng, Xianbao; Han, Yuepeng

    2015-01-01

    Cherry plum is a popular ornamental tree worldwide and most cultivars are selected for purple foliage. Here, we report the investigation of molecular mechanism underlying red pigmentation in purple-leaf plum 'Ziyeli' (Prunus cerasifera Ehrhar f. atropurpurea (Jacq.) Rehd.), which shows red color pigmentation in fruit (flesh and skin) and foliage. Six anthocyanin-activating MYB genes, designated PcMYB10.1 to PcMYB10.6, were isolated based on RNA-Seq data from leaves of cv. Ziyeli. Of these PcMYB10 genes, five (PcMYB10.1 through PcMYB10.5) show distinct spatial and temporal expression patterns, while the PcMYB10.6 gene is highly expressed in all the purple-coloured organs of cv. Ziyeli. Constitutive activation of PcMYB10.6 is closely related to red pigmentation in the leaf, fruit (flesh and skin), and sepal. However, the PcMYB10.6 activation cannot induce red pigmentation in the petal of cv. Ziyeli during late stages of flower development due to due to a lack of expression of PcUFGT. The inhibition of red pigmentation in the petal of cherry plum could be attributed to the high-level expression of PcANR that directs anthocyanidin flux to proanthocyanidin biosynthesis. In addition, PcMYB10.2 is highly expressed in fruit and sepal, but its expression cannot induce red pigmentation. This suggests the PcMYB10 gene family in cherry plum may have diverged in function and PcMYB10.2 plays little role in the regulation of red pigmentation. Our study provides for the first time an example of constitutive activation of an anthocyanin-activating MYB gene in Prunus although its underlying mechanism remains unclear. PMID:26247780

  9. Constitutive Activation of an Anthocyanin Regulatory Gene PcMYB10.6 Is Related to Red Coloration in Purple-Foliage Plum

    PubMed Central

    Zhou, Hui; Wang, Lu; Deng, Xianbao; Han, Yuepeng

    2015-01-01

    Cherry plum is a popular ornamental tree worldwide and most cultivars are selected for purple foliage. Here, we report the investigation of molecular mechanism underlying red pigmentation in purple-leaf plum ‘Ziyeli’ (Prunus cerasifera Ehrhar f. atropurpurea (Jacq.) Rehd.), which shows red color pigmentation in fruit (flesh and skin) and foliage. Six anthocyanin-activating MYB genes, designated PcMYB10.1 to PcMYB10.6, were isolated based on RNA-Seq data from leaves of cv. Ziyeli. Of these PcMYB10 genes, five (PcMYB10.1 through PcMYB10.5) show distinct spatial and temporal expression patterns, while the PcMYB10.6 gene is highly expressed in all the purple-coloured organs of cv. Ziyeli. Constitutive activation of PcMYB10.6 is closely related to red pigmentation in the leaf, fruit (flesh and skin), and sepal. However, the PcMYB10.6 activation cannot induce red pigmentation in the petal of cv. Ziyeli during late stages of flower development due to due to a lack of expression of PcUFGT. The inhibition of red pigmentation in the petal of cherry plum could be attributed to the high-level expression of PcANR that directs anthocyanidin flux to proanthocyanidin biosynthesis. In addition, PcMYB10.2 is highly expressed in fruit and sepal, but its expression cannot induce red pigmentation. This suggests the PcMYB10 gene family in cherry plum may have diverged in function and PcMYB10.2 plays little role in the regulation of red pigmentation. Our study provides for the first time an example of constitutive activation of an anthocyanin-activating MYB gene in Prunus although its underlying mechanism remains unclear. PMID:26247780

  10. iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

    PubMed Central

    Imrichová, Hana; Van de Sande, Bram; Standaert, Laura; Christiaens, Valerie; Hulselmans, Gert; Herten, Koen; Naval Sanchez, Marina; Potier, Delphine; Svetlichnyy, Dmitry; Kalender Atak, Zeynep; Fiers, Mark; Marine, Jean-Christophe; Aerts, Stein

    2014-01-01

    Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regulatory sequence analysis. iRegulon implements a genome-wide ranking-and-recovery approach to detect enriched transcription factor motifs and their optimal sets of direct targets. We increase the accuracy of network inference by using very large motif collections of up to ten thousand position weight matrices collected from various species, and linking these to candidate human TFs via a motif2TF procedure. We validate iRegulon on gene sets derived from ENCODE ChIP-seq data with increasing levels of noise, and we compare iRegulon with existing motif discovery methods. Next, we use iRegulon on more challenging types of gene lists, including microRNA target sets, protein-protein interaction networks, and genetic perturbation data. In particular, we over-activate p53 in breast cancer cells, followed by RNA-seq and ChIP-seq, and could identify an extensive up-regulated network controlled directly by p53. Similarly we map a repressive network with no indication of direct p53 regulation but rather an indirect effect via E2F and NFY. Finally, we generalize our computational framework to include regulatory tracks such as ChIP-seq data and show how motif and track discovery can be combined to map functional regulatory interactions among co-expressed genes. iRegulon is available as a Cytoscape plugin from http://iregulon.aertslab.org. PMID:25058159

  11. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Scroggins, Sharon; Duda, Kristen

    2008-01-01

    This viewgraph presentation gives an overview of NASA's risk analysis communication programs associated with changing environmental policies. The topics include: 1) NASA Program Transition; 2) Principal Center for Regulatory Risk Analysis and Communication (RRAC PC); and 3) Regulatory Tracking and Communication Process.

  12. Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells.

    PubMed

    Toliver-Kinsky, T; Wood, T; Perez-Polo, J R

    2000-12-01

    Anovel nuclear factor kappaB (NF-kappaB) binding site has been identified within the promoter region of the mouse gene encoding choline acetyltransferase (ChAT), the enzyme that synthesizes acetylcholine and has been implicated in the cognitive deficits associated with aging and Alzheimer's disease. This binding site, which is located within the nerve growth factor (NGF)-responsive enhancer element, was recognized by the NF-kappaB protein p49 but not p65 or p50. p49 from both basal forebrain and PC12 nuclear extracts interacted with this specific sequence in electrophoretic mobility shift assays. Mutation of the NF-kappaB site caused an increase in NGF-induced promoter activation, whereas overexpression of p49 in NGF-differentiated PC12 cells caused a decrease in endogenous ChAT enzyme activity and a decrease in promoter activity that was specifically mediated through this NF-kappaB binding site. Treatment of PC12 cells with NGF resulted in a drastic reduction in nuclear p49 binding to the ChAT NF-kappaB site after 24 h, but nuclear p49 levels were not altered, suggesting that late NGF-mediated events prevent binding of p49 to the ChAT promoter by an unknown mechanism other than nuclear translocation. Decreased ChAT expression and increased NF-kappaB activity in the brain are associated with aging and Alzheimer's disease. These data indicate that p49 is a negative regulator of ChAT expression and suggest a possible mechanism for aging-associated declines in cholinergic function.

  13. Measurement of Time-Averaged Particle-Wall Collision Properties Using Particle Tracking Velocimetry, CRADA PC93-006, Final Report

    SciTech Connect

    Shaffer, F.; Massah, H.; Sinclair, J.; Shahnam, M.

    1995-04-30

    This paper describes an experimental facility to measure time-averaged properties of particle-wall collisions. A particle tracking velocimetry (PTV) system measures particle rebound angles and velocities and impact angles and velocities for specific particles. From these measured properties, values of normal and tangential coefficient of restitution are derived. The PTV system rapidly measures thousands of particle-wall collisions enabling determination of time-averaged properties. In this initial work we use 191 {micro}m glass particles colliding with a glass plate at a fixed angle of 17.5{degree} and a velocity of 17.07 m/s. Observations are also made of aspherical particles colliding with gross sliding. In the future, this experimental system will be used with particles and wall materials of industrial significance.

  14. Biomimicry 1: PC.

    PubMed

    Cumberland, D C; Gunn, J; Malik, N; Holt, C M

    1998-01-01

    The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

  15. Peak Pc Prediction in Conjunction Analysis: Conjunction Assessment Risk Analysis. Pc Behavior Prediction Models

    NASA Technical Reports Server (NTRS)

    Vallejo, J.J.; Hejduk, M.D.; Stamey, J. D.

    2015-01-01

    Satellite conjunction risk typically evaluated through the probability of collision (Pc). Considers both conjunction geometry and uncertainties in both state estimates. Conjunction events initially discovered through Joint Space Operations Center (JSpOC) screenings, usually seven days before Time of Closest Approach (TCA). However, JSpOC continues to track objects and issue conjunction updates. Changes in state estimate and reduced propagation time cause Pc to change as event develops. These changes a combination of potentially predictable development and unpredictable changes in state estimate covariance. Operationally useful datum: the peak Pc. If it can reasonably be inferred that the peak Pc value has passed, then risk assessment can be conducted against this peak value. If this value is below remediation level, then event intensity can be relaxed. Can the peak Pc location be reasonably predicted?

  16. Beware the PC Police.

    ERIC Educational Resources Information Center

    Cheney, Lynne V.

    1992-01-01

    Decries the prevalence of "racism,""sexual harassment," and "speciesism" labels applied to supposed violators of "political correctness" (PC). When freedom of speech on college campuses is held hostage to political correctness, K-12 education is bound to be affected. This new brand of McCarthyism cheapens the concept of discrimination and stifles…

  17. Chromosomal Distribution of PcG Proteins during Drosophila Development

    PubMed Central

    Nègre, Nicolas; Hennetin, Jérôme; Sun, Ling V; Lavrov, Sergey; Bellis, Michel; White, Kevin P

    2006-01-01

    Polycomb group (PcG) proteins are able to maintain the memory of silent transcriptional states of homeotic genes throughout development. In Drosophila, they form multimeric complexes that bind to specific DNA regulatory elements named PcG response elements (PREs). To date, few PREs have been identified and the chromosomal distribution of PcG proteins during development is unknown. We used chromatin immunoprecipitation (ChIP) with genomic tiling path microarrays to analyze the binding profile of the PcG proteins Polycomb (PC) and Polyhomeotic (PH) across 10 Mb of euchromatin. We also analyzed the distribution of GAGA factor (GAF), a sequence-specific DNA binding protein that is found at most previously identified PREs. Our data show that PC and PH often bind to clustered regions within large loci that encode transcription factors which play multiple roles in developmental patterning and in the regulation of cell proliferation. GAF co-localizes with PC and PH to a limited extent, suggesting that GAF is not a necessary component of chromatin at PREs. Finally, the chromosome-association profile of PC and PH changes during development, suggesting that the function of these proteins in the regulation of some of their target genes might be more dynamic than previously anticipated. PMID:16613483

  18. GFI - EASY PC GRAPHICS

    NASA Technical Reports Server (NTRS)

    Katz, R. B.

    1994-01-01

    Easy PC Graphics (GFI) is a graphical plot program that permits data to be easily and flexibly plotted. Data is input in a standard format which allows easy data entry and evaluation. Multiple dependent axes are also supported. The program may either be run in a stand alone mode or be embedded in the user's own software. Automatic scaling is built in for several logarithmic and decibel scales. New scales are easily incorporated into the code through the use of object-oriented programming techniques. For the autoscale routines and the actual plotting code, data is not retrieved directly from a file, but a "method" delivers the data, performing scaling as appropriate. Each object (variable) has state information which selects its own scaling. GFI is written in Turbo Pascal version 6.0 for IBM PC compatible computers running MS-DOS. The source code will only compile properly with the Turbo Pascal v. 6.0 or v. 7.0 compilers; however, an executable is provided on the distribution disk. This executable requires at least 64K of RAM and DOS 3.1 or higher, as well as an HP LaserJet printer to print output plots. The standard distribution medium for this program is one 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. An electronic copy of the documentation is provided on the distribution medium in ASCII format. GFI was developed in 1993.

  19. PC index and magnetic substorms

    NASA Astrophysics Data System (ADS)

    Troshichev, Oleg; Janzhura, Alexander; Sormakov, Dmitry; Podorozhkina, Nataly

    PC index is regarded as a proxy of the solar wind energy that entered into the magnetosphere as distinct from the AL and Dst indices, which are regarded as characteristics of the energy that realize in the magnetosphere in form of substorm and magnetic storms. This conclusion is based on results of analysis of relationships between the polar cap magnetic activity (PC-index) and parameters of the solar wind, on the one hand, relationships between changes of PC and development of magnetospheric substorms (AL-index) and magnetic storms (Dst-index), on the other hand. This paper describes in detail the following main results which demonstrate a strong connection between the behavior of PC and development of magnetic disturbances in the auroral zone: (1) magnetic substorms are preceded by the РС index growth (isolated and extended substorms) or long period of stationary PC (postponed substorms), (2) the substorm sudden onsets are definitely related to such PC signatures as leap and reverse, which are indicative of sharp increase of the PC growth rate, (3) substorms generally start to develop when the PC index exceeds the threshold level ~ 1.5±0.5 mV/m, irrespective of the substorm growth phase duration and type of substorm, (4) linear dependency of AL values on PC is typical of all substorm events irrespective of type and intensity of substorm.

  20. Wanted: A Solid, Reliable PC

    ERIC Educational Resources Information Center

    Goldsborough, Reid

    2004-01-01

    This article discusses PC reliability, one of the most pressing issues regarding computers. Nearly a quarter century after the introduction of the first IBM PC and the outset of the personal computer revolution, PCs have largely become commodities, with little differentiating one brand from another in terms of capability and performance. Most of…

  1. NASA PC software evaluation project

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Kuan, Julie C.

    1986-01-01

    The USL NASA PC software evaluation project is intended to provide a structured framework for facilitating the development of quality NASA PC software products. The project will assist NASA PC development staff to understand the characteristics and functions of NASA PC software products. Based on the results of the project teams' evaluations and recommendations, users can judge the reliability, usability, acceptability, maintainability and customizability of all the PC software products. The objective here is to provide initial, high-level specifications and guidelines for NASA PC software evaluation. The primary tasks to be addressed in this project are as follows: to gain a strong understanding of what software evaluation entails and how to organize a structured software evaluation process; to define a structured methodology for conducting the software evaluation process; to develop a set of PC software evaluation criteria and evaluation rating scales; and to conduct PC software evaluations in accordance with the identified methodology. Communication Packages, Network System Software, Graphics Support Software, Environment Management Software, General Utilities. This report represents one of the 72 attachment reports to the University of Southwestern Louisiana's Final Report on NASA Grant NGT-19-010-900. Accordingly, appropriate care should be taken in using this report out of context of the full Final Report.

  2. Influence of track-etching on polycarbonate membrane permittivity

    NASA Astrophysics Data System (ADS)

    Allaeys, J.-F.; Marcilhac, B.; Mage, J.-C.

    2007-06-01

    The complex dielectric permittivity of track-etched polycarbonate (PC) membranes is measured and compared with raw polymer membranes. Membranes at different steps of the track-etching process are compared. Dielectric loss is a key factor for microwave nanowired substrate devices, and better knowledge of the materials is necessary for choosing the most suited polymer for applications. Our experimental data on track-etched and raw PC are similar, and the PC dielectric loss at every track-etching step is lower than the raw polyimide dielectric loss.

  3. D2PC sensitivity analysis

    SciTech Connect

    Lombardi, D.P.

    1992-08-01

    The Chemical Hazard Prediction Model (D2PC) developed by the US Army will play a critical role in the Chemical Stockpile Emergency Preparedness Program by predicting chemical agent transport and dispersion through the atmosphere after an accidental release. To aid in the analysis of the output calculated by D2PC, this sensitivity analysis was conducted to provide information on model response to a variety of input parameters. The sensitivity analysis focused on six accidental release scenarios involving chemical agents VX, GB, and HD (sulfur mustard). Two categories, corresponding to conservative most likely and worst case meteorological conditions, provided the reference for standard input values. D2PC displayed a wide variety of sensitivity to the various input parameters. The model displayed the greatest overall sensitivity to wind speed, mixing height, and breathing rate. For other input parameters, sensitivity was mixed but generally lower. Sensitivity varied not only with parameter, but also over the range of values input for a single parameter. This information on model response can provide useful data for interpreting D2PC output.

  4. Computer (PC/Network) Coordinator.

    ERIC Educational Resources Information Center

    Ohio State Univ., Columbus. Center on Education and Training for Employment.

    This publication contains 22 subjects appropriate for use in a competency list for the occupation of computer (PC/network) coordinator, 1 of 12 occupations within the business/computer technologies cluster. Each unit consists of a number of competencies; a list of competency builders is provided for each competency. Titles of the 22 units are as…

  5. ICAN - INTEGRATED COMPOSITE ANALYZER (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Murthy, P. L.

    1994-01-01

    , macromechanics, and laminate analysis including the hygrothermal response of fiber composites. ICAN output includes the various ply and composite properties, composite structural response, and composite stress analysis results with details of failure. Output can be tailored to specific needs by choosing the appropriate options. Two machine versions of ICAN are available. The IBM 370 series version (LEW-14468) is written in FORTRAN IV for the IBM 370 series computers running OS/TSS. The IBM PC version (LEW-15592) is written in FORTRAN 77 for use on the IBM PC series computers running MS-DOS and Microsoft FORTRAN 5.1. The IBM 370 version requires 3.5Mb of memory for execution. No sample executable is provided. For the IBM PC version, a sample executable, along with sample input and output data, is included on the distribution medium. Although the included executable requires a math coprocessor, the ICAN source can be recompiled into an executable which does not require a math coprocessor. The standard distribution medium for the IBM 370 version of ICAN is a 9-track 1600 BPI magnetic tape in EBCDIC CARD IMAGE format. The standard distribution medium for the IBM PC version is one 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. ICAN was developed in 1986 and the IBM PC version was released in 1992.

  6. Poster session ELIPGRID-PC

    SciTech Connect

    Davidson, J.R.

    1995-02-01

    ELIPGRID-PC, a new personal computer program, has been developed to provide easy access to Singer`s ELIPGRID algorithm for hot-spot detection probabilities. Three features of the program are the ability to determine: (1) the grid size required for specified conditions, (2) the smallest hot spot that can be sampled with a given probability, and (3) the approximate grid size resulting from specified conditions and sampling cost. ELIPGRID-PC also provides probability of detection versus cost data for graphing with spreadsheets or graphics software. The program has been successfully tested using Singer`s published ELIPGRID results. An apparent error in the published ELIPGRID code has been uncovered and an appropriate modification incorporated into the new program.

  7. The Pathogen-annotated Tracking Resource Network (PATRN) system: a web-based resource to aid food safety, regulatory science, and investigations of foodborne pathogens and disease.

    PubMed

    Gopinath, G; Hari, K; Jain, R; Mammel, M K; Kothary, M H; Franco, A A; Grim, C J; Jarvis, K G; Sathyamoorthy, V; Hu, L; Datta, A R; Patel, I R; Jackson, S A; Gangiredla, J; Kotewicz, M L; LeClerc, J E; Wekell, M; McCardell, B A; Solomotis, M D; Tall, B D

    2013-06-01

    Investigation of foodborne diseases requires the capture and analysis of time-sensitive information on microbial pathogens that is derived from multiple analytical methods and sources. The web-based Pathogen-annotated Tracking Resource Network (PATRN) system (www.patrn.net) was developed to address the data aggregation, analysis, and communication needs important to the global food safety community for the investigation of foodborne disease. PATRN incorporates a standard vocabulary for describing isolate metadata and provides a representational schema for a prototypic data exchange standard using a novel data loading wizard for aggregation of assay and attribution information. PATRN currently houses expert-curated, high-quality "foundational datasets" consisting of published experimental results from conventional assays and next generation analysis platforms for isolates of Escherichia coli, Listeria monocytogenes, and Salmonella, Shigella, Vibrio and Cronobacter species. A suite of computational tools for data mining, clustering, and graphical representation is available. Within PATRN, the public curated data repository is complemented by a secure private workspace for user-driven analyses, and for sharing data among collaborators. To demonstrate the data curation, loading wizard features, and analytical capabilities of PATRN, three use-case scenarios are presented. Use-case scenario one is a comparison of the distribution and prevalence of plasmid-encoded virulence factor genes among 249 Cronobacter strains with similar attributes to that of nine Cronobacter isolates from recent cases obtained between March and October, 2010-2011. To highlight PATRN's data management and trend finding tools, analysis of datasets, stored in PATRN as part of an ongoing surveillance project to identify the predominant molecular serogroups among Cronobacter sakazakii isolates observed in the USA is shown. Use-case scenario two demonstrates the secure workspace available for private

  8. The Pathogen-annotated Tracking Resource Network (PATRN) system: a web-based resource to aid food safety, regulatory science, and investigations of foodborne pathogens and disease.

    PubMed

    Gopinath, G; Hari, K; Jain, R; Mammel, M K; Kothary, M H; Franco, A A; Grim, C J; Jarvis, K G; Sathyamoorthy, V; Hu, L; Datta, A R; Patel, I R; Jackson, S A; Gangiredla, J; Kotewicz, M L; LeClerc, J E; Wekell, M; McCardell, B A; Solomotis, M D; Tall, B D

    2013-06-01

    Investigation of foodborne diseases requires the capture and analysis of time-sensitive information on microbial pathogens that is derived from multiple analytical methods and sources. The web-based Pathogen-annotated Tracking Resource Network (PATRN) system (www.patrn.net) was developed to address the data aggregation, analysis, and communication needs important to the global food safety community for the investigation of foodborne disease. PATRN incorporates a standard vocabulary for describing isolate metadata and provides a representational schema for a prototypic data exchange standard using a novel data loading wizard for aggregation of assay and attribution information. PATRN currently houses expert-curated, high-quality "foundational datasets" consisting of published experimental results from conventional assays and next generation analysis platforms for isolates of Escherichia coli, Listeria monocytogenes, and Salmonella, Shigella, Vibrio and Cronobacter species. A suite of computational tools for data mining, clustering, and graphical representation is available. Within PATRN, the public curated data repository is complemented by a secure private workspace for user-driven analyses, and for sharing data among collaborators. To demonstrate the data curation, loading wizard features, and analytical capabilities of PATRN, three use-case scenarios are presented. Use-case scenario one is a comparison of the distribution and prevalence of plasmid-encoded virulence factor genes among 249 Cronobacter strains with similar attributes to that of nine Cronobacter isolates from recent cases obtained between March and October, 2010-2011. To highlight PATRN's data management and trend finding tools, analysis of datasets, stored in PATRN as part of an ongoing surveillance project to identify the predominant molecular serogroups among Cronobacter sakazakii isolates observed in the USA is shown. Use-case scenario two demonstrates the secure workspace available for private

  9. PC25{trademark} product and manufacturing experience

    SciTech Connect

    Hall, E.W.; Riley, W.C.; Sandelli, G.J.

    1996-12-31

    Product and manufacturing experience accumulated since the beginning of PC25. A production in 1991 provides a strong base of demonstration and experience for establishing future improvements to the PC25 power plant.

  10. SI PC104 Performance Test Report

    SciTech Connect

    Montelongo, S

    2005-12-16

    The Spectral Instruments (SI) PC104 systems associated with the SI-1000 CCD camera exhibited intermittent power problems during setup, test and operations which called for further evaluation and testing. The SI PC104 System is the interface between the SI-1000 CCD camera and its associated Diagnostic Controller (DC). As such, the SI PC104 must be a reliable, robust system capable of providing consistent performance in various configurations and operating conditions. This SI PC104 system consists of a stackable set of modules designed to meet the PC104+ Industry Standard. The SI PC104 System consists of a CPU module, SI Camera card, Media converter card, Video card and a I/O module. The root cause of power problems was identified as failing solder joints at the LEMO power connector attached to the SI Camera Card. The recommended solution was to provide power to the PC104 system via a PC104+ power supply module configured into the PC104 stack instead of thru the LEMO power connector. Test plans (2) were developed to test SI PC104 performance and identify any outstanding issues noted during extended operations. Test Plan 1 included performance and image acquisition tests. Test Plan 2 verified performance after implementing recommendations. Test Plan 2 also included verifying integrity of system files and driver installation after bootup. Each test plan was implemented to fully test against each set of problems noted. Test Plan presentations and Test Plan results are attached as appendices. Anticipated test results will show successful operation and reliable performance of the SI PC104 system receiving its power via a PC104 power supply module. A SI PC104 Usage Recommendation Memo will be sent out to the SI PC104 User Community. Recommendation memo(s) are attached as appendices.

  11. PC/104 Embedded IOCs at Jefferson Lab

    SciTech Connect

    Jianxun Yan, Trent Allison, Sue Witherspoon, Anthony Cuffe

    2009-10-01

    Jefferson Lab has developed embedded IOCs based on PC/104 single board computers (SBC) for low level control systems. The PC/104 IOCs run EPICS on top of the RTEMS operating system. Two types of control system configurations are used in different applications, PC/104 SBC with commercial PC/104 I/O cards and PC/104 SBC with custom designed FPGA-based boards. RTEMS was built with CEXP shell to run on the PC/104 SBC. CEXP shell provides the function of dynamic object loading, which is similar to the widely used VxWorks operating system. Standard software configurations were setup for PC/104 IOC application development to provide a familiar format for new projects as well as ease the conversion of applications from VME based IOCs to PC/104 IOCs. Many new projects at Jefferson Lab are going to employ PC/104 SBCs as IOCs and some applications have already been running them for accelerator operations. The PC/104 - RTEMS IOC provides a free open source Real-Time Operating System (RTOS), low cost/maintenance, easily installed/ configured, flexible, and reliable solution for accelerator control and 12GeV Upgrade projects.

  12. PC Basic Linear Algebra Subroutines

    1992-03-09

    PC-BLAS is a highly optimized version of the Basic Linear Algebra Subprograms (BLAS), a standardized set of thirty-eight routines that perform low-level operations on vectors of numbers in single and double-precision real and complex arithmetic. Routines are included to find the index of the largest component of a vector, apply a Givens or modified Givens rotation, multiply a vector by a constant, determine the Euclidean length, perform a dot product, swap and copy vectors, andmore » find the norm of a vector. The BLAS have been carefully written to minimize numerical problems such as loss of precision and underflow and are designed so that the computation is independent of the interface with the calling program. This independence is achieved through judicious use of Assembly language macros. Interfaces are provided for Lahey Fortran 77, Microsoft Fortran 77, and Ryan-McFarland IBM Professional Fortran.« less

  13. Beyond Tracking.

    ERIC Educational Resources Information Center

    Bates, Percy; And Others

    1992-01-01

    On the surface, educational tracking may seem like a useful tool for allowing students to work at their own pace, and to avoid discouraging competition, but abuses of the tracking idea have arisen through biased placement practices that have denied equal access to education for minority students. The articles in this issue explore a number of…

  14. Derailing Tracking.

    ERIC Educational Resources Information Center

    Black, Susan

    1993-01-01

    Reviews recent research on student achievement, self-concept, and curriculum and instruction showing the ineffectiveness of tracking and ability grouping. Certain court rulings show that tracking violates the equal protection clause of the Fourteenth Amendment. Innovative alternatives include cooperative learning, mastery learning, peer tutoring,…

  15. Fuzzy logic particle tracking velocimetry

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.

    1993-01-01

    Fuzzy logic has proven to be a simple and robust method for process control. Instead of requiring a complex model of the system, a user defined rule base is used to control the process. In this paper the principles of fuzzy logic control are applied to Particle Tracking Velocimetry (PTV). Two frames of digitally recorded, single exposure particle imagery are used as input. The fuzzy processor uses the local particle displacement information to determine the correct particle tracks. Fuzzy PTV is an improvement over traditional PTV techniques which typically require a sequence (greater than 2) of image frames for accurately tracking particles. The fuzzy processor executes in software on a PC without the use of specialized array or fuzzy logic processors. A pair of sample input images with roughly 300 particle images each, results in more than 200 velocity vectors in under 8 seconds of processing time.

  16. 75 FR 62005 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-07

    ... proposed AD. Discussion On August 18, 2009, we issued AD 2009-18-03, Amendment 39-15999 (74 FR 43636... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will.... 39.13 by removing Amendment 39-15999 (74 FR 43636; August 27, 2009), and adding the following new...

  17. STS-30 deorbit and reentry ground track

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Rockwell International (RI) supplied artist concept titled 'STS-30 Deorbit and Reentry Track' shows Atlantis, Orbiter Vehicle (OV) 104, deorbit and reentry ground track. Ground track and map portray OV-104's deorbit over Madagascar, atmospheric reentry maneuvers, approach to the California coast, and landing at Edwards Air Force Base (EAFB), California. the transport trailer of the Payload Environmental Transportation System (PETS). Magellan, destined for unprecedented studies of Venusian topographic features, will be deployed by the crew of NASA's STS-30 mission in April 1989. View provided by KSC with alternate number KSC-88PC-1086.

  18. Rover tracks

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Tracks made by the Sojourner rover are visible in this image, taken by one of the cameras aboard Sojourner on Sol 3. The tracks represent the rover maneuvering towards the rock dubbed 'Barnacle Bill.' The rover, having exited the lander via the rear ramp, first traveled towards the right portion of the image, and then moved forward towards the left where Barnacle Bill sits. The fact that the rover was making defined tracks indicates that the soil is made up of particles on a micron scale.

    Mars Pathfinder was developed and managed by the Jet Propulsion Laboratory (JPL) for the National Aeronautics and Space Administration.

  19. Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.

    PubMed

    Pinkert, C A; Manz, J; Linton, P J; Klinman, N R; Storb, U

    1989-12-01

    The rearrangement of heavy and light chain immunoglobulin genes is necessary for the production of functional antibody molecules. The myeloma MOPC 167 produces specific antibodies to the antigen phosphorylcholine (PC), which is present on bacterial surfaces, fungi and other environmental contaminants. Rearranged heavy and light chain immunoglobulin genes cloned from MOPC 167 were microinjected into mouse eggs. Within the resulting transgenic mice, expression of the transgenes were limited to lymphoid tissues. Transgenic mice produced elevated levels of anti-PC antibodies constitutively, at 16 days of age, when normal non-transgenic mice were not fully immunocompetent. A triggering antigenic stimulus was not necessary to evoke anti-PC immunoglobulin production. Additionally, the frequency of PC-responsive B cells in these transgenic mice was further increased upon specific immunization.

  20. Dispersive Pc1 bursts observed by Freja

    SciTech Connect

    Mursula, K.; Braeysy, T.; Rasinkangas, R.; Tanskanen, P.; Blomberg, L.G.; Lindqvist, P.A.; Marklund, G.T.

    1994-08-15

    The authors report on observation of electromagnetic ion cyclotron waves (Pc1 pulsations) by the Freja satellite on November 18, 1992. These observations are coincident with ground based observation of such pearl like Pc1 pulsations extending over a 12 hour period. This is the first observation by a satellite above the ionosphere of such phenomena. The wave pulsations were observed to come in 10 to 25 second pulses, and to be clearly dispersive in nature. Two spectral bands were observed in all Pc1 pearls. In the longer bursts, the authors observed time differences between the two distinct spectral bands.

  1. GOMER: a PC-based expert system

    SciTech Connect

    Cochrell, G.D.

    1986-04-01

    The algorithm for a PC-based expert system for interpretation of seismic data from remote sensors is described. The original expert system was written on a Symbolics computer using Zeta LISP. The PC version is written in Pascal and runs on the IBM PC or on any IBM-compatible computer. The Pascal source code is included with this report. To date the software has been used only on simulated sensor data but will be modified to accept data from fielded sensors. Extensive field testing will be required to refine the program's knowledge base. 8 figs.

  2. The PC index: review of methods

    NASA Astrophysics Data System (ADS)

    McCreadie, H.; Menvielle, M.

    2010-10-01

    The Polar Cap (PC) index is a controversial topic within the IAGA scientific community. Since 1997 discussions of the validity of the index to be endorsed as an official IAGA index have ensued. There is no doubt as to the scientific merit of the index which is not discussed here. What is in doubt is the methodology of the derivation of the index by different groups. The Polar Cap index (PC: PCN, northern; PCS, southern) described in Troshichev et al. (2006) and Stauning et al. (2006), both termed the "unified PC index", and the PCN index routinely derived at DMI are inspected using only available published literature. They are found to contain different derivation procedures, thus are not unified. The descriptions of the derivation procedures are found to not be adequate to independently derive the PC indices.

  3. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER... nationally tracked sources. Each licensee who manufactures a nationally tracked source after February 6,...

  4. 10 CFR 32.201 - Serialization of nationally tracked sources.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Serialization of nationally tracked sources. 32.201 Section 32.201 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER... nationally tracked sources. Each licensee who manufactures a nationally tracked source after February 6,...

  5. [Functions of prion protein PrPc].

    PubMed

    Cazaubon, Sylvie; Viegas, Pedro; Couraud, Pierre-Olivier

    2007-01-01

    It is now well established that both normal and pathological (or scrapie) isoforms of prion protein, PrPc and PrPsc respectively, are involved in the development and progression of various forms of neurodegenerative diseases, including scrapie in sheep, bovine spongiform encephalopathy (or "mad cow disease") and Creutzfeldt-Jakob disease in human, collectively known as prion diseases. The protein PrPc is highly expressed in the central nervous system in neurons and glial cells, and also present in non-brain cells, such as immune cells or epithelial and endothelial cells. Identification of the physiological functions of PrPc in these different cell types thus appears crucial for understanding the progression of prion diseases. Recent studies highlighted several major roles for PrPc that may be considered in two major domains : (1) cell survival (protection against oxidative stress and apoptosis) and (2) cell adhesion. In association with cell adhesion, distinct functions of PrPc were observed, depending on cell types : neuronal differentiation, epithelial and endothelial barrier integrity, transendothelial migration of monocytes, T cell activation. These observations suggest that PrPc functions may be particularly relevant to cellular stress, as well as inflammatory or infectious situations. PMID:17875293

  6. Management and transmission of DICOM files using PC to PC multicasting methodology.

    PubMed

    Kim, I K; Kwon, G B; Choi, W K; Cho, H; Kwak, Y S

    2001-01-01

    The PACS system built and used in hospitals nowadays has quite significant overload on its central server because of both treatment of very large data and full management of medical images. We suggest a distributed communication and management methodology using PC to PC multicasting strategy for efficient management of medical images produced by DICOM modalities. It is absolutely necessary for reducing strict degradation of PACS system due to large size of medical images and its very high transport rates. DICOM PC to PC component is composed a service manager to execute requested queries, a communication manager to take charge of file transmission, and a DICOM manager to manage stored data and system behavior. Each manager itself is a component to search for requested file by interaction or transmit the file to other PCs. Distributed management and transformation of medical information based on PC to PC multicasting methodology will enhance performance of central server and network capacity reducing overload on them.

  7. Power-cable-carrier control (PC/sup 3/) system

    SciTech Connect

    Alvis, R.L.; Wally, K.; Rosborough, J.R.

    1981-04-01

    A control system has been developed that uses a carrier signal imposed on an existing ac power circuit to transmit commands. This system was specifically developed to control an entire solar collector field by sending sun-tracking information to the trough collectors or by commanding them to assume safe positions (STOW) if out-of-limit conditions were encountered. Objectives were to develop a control system that operates reliably and has enough functions to control an entire collector field, yet do it at less cost than for conventional approaches. Development, design, operating characteristics, and field testing and results of the new system, the Power Cable Carrier Control (PC/sup 3/) System are described.

  8. Mission Risk Reduction Regulatory Change Management

    NASA Technical Reports Server (NTRS)

    Scroggins, Sharon

    2007-01-01

    NASA Headquarters Environmental Management Division supports NASA's mission to pioneer the future in space exploration, scientific discovery, and aeronautics research by integrating environmental considerations into programs and projects early-on, thereby proactively reducing NASA's exposure to institutional, programmatic and operational risk. As part of this effort, NASA established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) as a resource for detecting, analyzing, and communicating environmental regulatory risks to the NASA stakeholder community. The RRAC PC focuses on detecting emerging environmental regulations and other operational change drivers that may pose risks to NASA programs and facilities, and effectively communicating the potential risks. For example, regulatory change may restrict how and where certain activities or operations may be conducted. Regulatory change can also directly affect the ability to use certain materials by mandating a production phase-out or restricting usage applications of certain materials. Regulatory change can result in significant adverse impacts to NASA programs and facilities due to NASA's stringent performance requirements for materials and components related to human-rated space vehicles. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented a system for proactively managing regulatory change to minimize potential adverse impacts to NASA programs and facilities. This presentation highlights the process utilized by the RRACPC to communicate regulatory change and the associated

  9. Particle displacement tracking for PIV

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.

    1990-01-01

    A new Particle Imaging Velocimetry (PIV) data acquisition and analysis system, which is an order of magnitude faster than any previously proposed system has been constructed and tested. The new Particle Displacement Tracing (PDT) system is an all electronic technique employing a video camera and a large memory buffer frame-grabber board. Using a simple encoding scheme, a time sequence of single exposure images are time coded into a single image and then processed to track particle displacements and determine velocity vectors. Application of the PDT technique to a counter-rotating vortex flow produced over 1100 velocity vectors in 110 seconds when processed on an 80386 PC.

  10. CONCEPT OF OPERATIONS PLANS for Phase I the INTERNATIONAL PILOT FOR Global Radiological source SORTING, Tracking, AND MONITORING (GradSStraM) Using eMERGING RFID AND WEB 2.0 TECHNOLOGIES TO PROVIDE TOTAL ASSET AND INFORMATION VISUALIZATIONA United states- European Union Lighthouse Priority Project for fostering trade and reducing regulatory burden

    SciTech Connect

    Walker, Randy M

    2009-01-01

    Thousands of shipments of radioisotopes developed in the United States (US) are transported domestically and internationally for medical and industrial applications, including to partner laboratories in European Union (EU) countries. Over the past five years, the Environmental Protection Agency (EPA), the Department of Energy (DOE), and Oak Ridge National Laboratory (ORNL) have worked with state regulatory compliance personnel, key private sector shippers and carriers, the Department of Homeland Security (DHS), the Department of Transportation (DOT), the Department of Defense (DoD) and the Nuclear Regulatory Commission (NRC) on Radio Frequency Identification (RFID) tracking and monitoring of medical and industrial radioisotopes in commerce. The EPA Radiological Source Tracking and Monitoring (RadSTraM) project tested, evaluated, and integrated RFID technologies in laboratory settings, and at multiple private-sector shipping and distribution facilities (Perkin Elmer and DHL) using common radioisotopes used in everyday commerce. The RFID tracking was also tested in association with other deployed technologies including radiation detection, chemical/explosives detection, advanced imaging, lasers, and infrared scanning. At the 2007 EU-US Summit, the leaders of the US Department of Commerce (DOC) and EU European Commission (EC) committed to pursue jointly directed Lighthouse Priority Projects. These projects are intended to 'foster cooperation' and 'reduce regulatory burdens' with respect to transatlantic commerce. The Transatlantic Economic Council (TEC) Lighthouse Project on Radio Frequency Identification (RFID) has been directed to 'develop a joint framework for cooperation on identification and development of best practices for Radio Frequency Identification (RFID) technologies.' The RFID Lighthouse Priority Project commits both sides to endeavor to align U.S. and EU regulatory and policy approaches on RFID technologies, including pilot projects in the public sector

  11. Broad spectral sensitivity and improved efficiency in CuPc/Sub-Pc organic photovoltaic devices

    NASA Astrophysics Data System (ADS)

    Kumar, Hemant; Kumar, Pankaj; Bhardwaj, Ramil; Sharma, G. D.; Chand, Suresh; Jain, S. C.; Kumar, Vikram

    2009-01-01

    We demonstrate organic photovoltaic devices incorporating two donors, namely, copper phthalocyanine (CuPc) and boron sub-phthalocyanine chloride (Sub-Pc) in association with single acceptor fullerene (C60) with sensitivity extending across the visible solar spectrum. It has been found that the absorption in different spectral regions in CuPc and Sub-Pc results in efficient harvesting of incident light photons which leads to enhanced power conversion efficiency (η). An enhancement in η from 0.64%, in the device architecture indium-tin-oxide (ITO)/CuPc(20 nm)/C60(40 nm)/bathophenanthroline (BPhen) (8 nm)/Al(150 nm), to ~1.3% in the optimized device having a 2 nm layer of Sub-Pc in the geometry ITO/CuPc(18 nm)/Sub-Pc(2 nm)/C60 (40 nm)/BPhen (8 nm)/Al(150 nm) has been observed. This enhancement in η is dominantly attributed to the increment in short circuit current density (Jsc) due to efficient photon harvesting by incorporation of dual donors.

  12. The IBM PC at NASA Ames

    NASA Technical Reports Server (NTRS)

    Peredo, James P.

    1988-01-01

    Like many large companies, Ames relies very much on its computing power to get work done. And, like many other large companies, finding the IBM PC a reliable tool, Ames uses it for many of the same types of functions as other companies. Presentation and clarification needs demand much of graphics packages. Programming and text editing needs require simpler, more-powerful packages. The storage space needed by NASA's scientists and users for the monumental amounts of data that Ames needs to keep demand the best database packages that are large and easy to use. Availability to the Micom Switching Network combines the powers of the IBM PC with the capabilities of other computers and mainframes and allows users to communicate electronically. These four primary capabilities of the PC are vital to the needs of NASA's users and help to continue and support the vast amounts of work done by the NASA employees.

  13. 3D Finite Element Analysis of Some Structural Modified PC Sleeper with the Vibration Characteristics between Sleeper and Ballast

    NASA Astrophysics Data System (ADS)

    Sakai, Hirotaka; Urakawa, Fumihiro; Aikawa, Akira; Namura, Akira

    The vibration of concrete sleepers is an important factor engendering track deterioration. In this paper, we created a three-dimensional finite element model to reproduce a prestressed concrete (PC) sleeper in detail, expressing influence of ballast layers with a 3D spring series and dampers to reproduce their vibration and dynamic characteristics. Determination of these parameters bases on the experimental modal analysis using an impact excitation technique for PC sleepers by adjusting the accelerance between the analytical results and experimental results. Furthermore, we compared the difference of these characteristics between normal sleepers and those with some structural modifications. Analytical results clarified that such means as sleeper width extension and increased sleeper thickness will influence the reduction of ballasted track vibration as improvements of PC sleepers.

  14. Computer program TRACK_VISION for simulating optical appearance of etched tracks in CR-39 nuclear track detectors

    NASA Astrophysics Data System (ADS)

    Nikezic, D.; Yu, K. N.

    2008-04-01

    A computer program called TRACK_VISION for determining the optical appearances of tracks in nuclear track materials resulted from light-ion irradiation and subsequent chemical etching was described. A previously published software, TRACK_TEST, was the starting point for the present software TRACK_VISION, which contained TRACK_TEST as its subset. The programming steps were outlined. Descriptions of the program were given, including the built-in V functions for the commonly employed nuclear track material commercially known as CR-39 (polyallyldiglycol carbonate) irradiated by alpha particles. Program summaryProgram title: TRACK_VISION Catalogue identifier: AEAF_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEAF_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 4084 No. of bytes in distributed program, including test data, etc.: 71 117 Distribution format: tar.gz Programming language: Fortran 90 Computer: Pentium PC Operating system: Windows 95+ RAM: 256 MB Classification: 17.5, 18 External routines: The entire code must be linked with the MSFLIB library. MSFLib is a collection of C and C++ modules which provides a general framework for processing IBM's AFP datastream. MSFLIB is specific to Visual Fortran (Digital, Compaq or Intel flavors). Nature of problem: Nuclear track detectors are commonly used for radon measurements through studying the tracks generated by the incident alpha particles. Optical microscopes are often used for this purpose but the process is relatively tedious and time consuming. Several automatic and semi-automatic systems have been developed in order to facilitate determination of track densities. In all these automatic systems, the optical appearance of the tracks is important. However, not much has been done so far to obtaining the

  15. Real-time face tracking

    NASA Astrophysics Data System (ADS)

    Liang, Yufeng; Wilder, Joseph

    1998-10-01

    A real-time face tracker is presented in this paper. The system has achieved 15 frames/second tracking using a Pentium 200 PC with a Datacube MaxPCI image processing board and a Panasonic RGB color camera. It tracks human faces in the camera's field of view while people move freely. A stochastic model to characterize the skin color distribution of human skin is used to segment the face and other skin areas from the background. Median filtering is then used to clean up the background noise. Geometric constraints are applied to the segmented image to extract the face from the background. To reduce computation and achieve real-time tracking, 1D projections (horizontal and vertical) of the image are analyzed instead of the 2D image. Run-length- encoding and frequency domain analysis algorithms are used to separate faces from other skin-like blobs. The system is robust to illumination intensity variations and different skin colors. It can be applied to many human-computer interaction applications such as sound locating, lip- reading, gaze tracking and face recognition.

  16. Stretch Your PC Dollars--Buy Clones.

    ERIC Educational Resources Information Center

    True, John

    1986-01-01

    Relates how the story of how San Francisco State University evaluated IBM PC look-alikes, considered some of the risks involved, and decided to purchase over 100 of them. Questions of compatibility, vendor longevity, support, and other risk management issues are discussed. (Author/MLW)

  17. New unifying procedure for PC index calculations.

    NASA Astrophysics Data System (ADS)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) index is a controversial topic within the IAGA scientific community. Since 1997 discussions of the validity of the index to be endorsed as an official IAGA index have ensued. Currently, there are now the three separate PC index versions constructed from the different procedures used at the three institutes: the Arctic and Antarctic Research Institute (AARI), the Danish Meteorological Institute (DMI), and the Danish National Space Institute (DTU Space). It is demonstrated in this presentation, that two consistent unifying procedures can be built from the best elements of the three different versions. One procedure uses a set of coefficients aimed at the calculation of final PC index values to be accepted by IAGA. The other procedure uses coefficients aimed at on-line real-time production of preliminary PC index values for Space Weather monitoring applications. For each of the two cases the same procedure is used for the northern (PCN) and the southern (PCS) polar cap indices, and the derived PCN and PCS coefficients are similar.

  18. NASTRAN data deck generation on the PC

    NASA Technical Reports Server (NTRS)

    Guyan, R. J.

    1986-01-01

    Using two commercial programs an application was developed to aid in generating a run-ready NASTRAN data deck on the PC. Macros are used to access relevant reference material and card files while editing the deck. The application can be easily customized to suit individual or group needs.

  19. Mathematics Instruction and the Tablet PC

    ERIC Educational Resources Information Center

    Fister, K. Renee; McCarthy, Maeve L.

    2008-01-01

    The use of tablet PCs in teaching is a relatively new phenomenon. A cross between a notebook computer and a personal digital assistant (PDA), the tablet PC has all of the features of a notebook with the additional capability that the screen can also be used for input. Tablet PCs are usually equipped with a stylus that allows the user to write on…

  20. Jargon that Computes: Today's PC Terminology.

    ERIC Educational Resources Information Center

    Crawford, Walt

    1997-01-01

    Discusses PC (personal computer) and telecommunications terminology in context: Integrated Services Digital Network (ISDN); Asymmetric Digital Subscriber Line (ADSL); cable modems; satellite downloads; T1 and T3 lines; magnitudes ("giga-,""nano-"); Central Processing Unit (CPU); Random Access Memory (RAM); Universal Serial Bus (USB); "Firewire,"…

  1. PC Kiosk Trends in Rural India

    ERIC Educational Resources Information Center

    Toyama, Kentaro; Kiri, Karishma; Menon, Deepak; Sethi, Suneet; Pal, Joyojeet; Srinivasan, Janaki

    2006-01-01

    This article presents a series of preliminary, quantitative results on rural PC kiosks in India. An analysis of the data confirms many expected trends and correlations and shows that kiosks still face the challenge of sustainability as a business. This study is based on questionnaires presented to kiosk operators and customers of kiosks operated…

  2. Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2.

    PubMed Central

    Bailyes, E M; Shennan, K I; Usac, E F; Arden, S D; Guest, P C; Docherty, K; Hutton, J C

    1995-01-01

    Human prohormone convertase PC2 was expressed in Xenopus oocytes and its properties were compared with those of the Type-2 endopeptidase of rat insulin secretory granules, previously identified as PC2 [Bennett, Bailyes, Nielson, Guest, Rutherford, Arden and Hutton (1992) J. Biol. Chem. 267, 15229-15236]. Recombinant PC2 had the same substrate specificity as the Type-2 endopeptidase, cleaving at the CA-junction (Lys64, Arg65) of human des-31,32-proinsulin to generate insulin; little activity was found toward human des-64,65-proinsulin or proinsulin itself. Recombinant PC2 was maximally active in 5-7 mM Ca2+ (K0.5 = 1.6 mM) whereas the Type-2 endopeptidase was maximally active in 0.5-1 mM Ca2+ (K0.5 = 40 microM). Both enzymes had a pH optimum of 5.0-5.5 but the Type-2 endopeptidase was active over a wider pH range. Two molecular forms of recombinant PC2 (71 kDa and 68 kDa) were found, both had an intact C-terminus but differed by the presence of the propeptide. The endogenous PC2 comprised several overlapping forms (size range 64-68 kDa), approximately two-thirds of which lacked C-terminal immunoreactivity. Part of the size difference between recombinant and endogenous PC2 was attributable to differences in N-glycosylation. The different post-translational proteolytic modifications of recombinant and endogenous PC2 did not account for the different pH and Ca2+ sensitivities shown by the enzymes. A modulating effect of carbohydrate on enzyme activity could not be excluded. Images Figure 2 Figure 3 Figure 5 Figure 6 Figure 7 PMID:7626024

  3. Boulder Track

    NASA Technical Reports Server (NTRS)

    2003-01-01

    MGS MOC Release No. MOC2-408, 1 July 2003

    If a boulder rolls down a slope on an uninhabited planet, does it make a sound? While we do not know the sound made by a boulder rolling down a slope in the martian region of Gordii Dorsum, we do know that it made an impression. This full-resolution Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a series of depressions made on a dust-mantled slope as a boulder rolled down it, sometime in the recent past. The boulder track is located just right of center in this picture. The boulder sits at the end of the track. This picture was acquired in May 2003; it is located near 11.2oN, 147.8oW. North is toward the lower left, sunlight illuminates the scene from the right. The picture covers an area only 810 meters (about 886 yards) across.

  4. IBM PC enhances the world's future

    NASA Technical Reports Server (NTRS)

    Cox, Jozelle

    1988-01-01

    Although the purpose of this research is to illustrate the importance of computers to the public, particularly the IBM PC, present examinations will include computers developed before the IBM PC was brought into use. IBM, as well as other computing facilities, began serving the public years ago, and is continuing to find ways to enhance the existence of man. With new developments in supercomputers like the Cray-2, and the recent advances in artificial intelligence programming, the human race is gaining knowledge at a rapid pace. All have benefited from the development of computers in the world; not only have they brought new assets to life, but have made life more and more of a challenge everyday.

  5. A PC based fault diagnosis expert system

    NASA Technical Reports Server (NTRS)

    Marsh, Christopher A.

    1990-01-01

    The Integrated Status Assessment (ISA) prototype expert system performs system level fault diagnosis using rules and models created by the user. The ISA evolved from concepts to a stand-alone demonstration prototype using OPS5 on a LISP Machine. The LISP based prototype was rewritten in C and the C Language Integrated Production System (CLIPS) to run on a Personal Computer (PC) and a graphics workstation. The ISA prototype has been used to demonstrate fault diagnosis functions of Space Station Freedom's Operation Management System (OMS). This paper describes the development of the ISA prototype from early concepts to the current PC/workstation version used today and describes future areas of development for the prototype.

  6. PC-based automation system streamlines operations

    SciTech Connect

    Bowman, J.

    1995-10-01

    The continued emergence of PC-based automation systems in the modern compressor station is driving the need for personnel who have the special skills need to support them. However, the dilemma is that operating budget restraints limit the overall number of people available to operate and maintain compressor stations. An ideal solution is to deploy automation systems which can be easily understood and supported by existing compressor station personnel. This paper reviews such a system developed by Waukesha-Pearce Industries, Inc.

  7. Virtual Reality at the PC Level

    NASA Technical Reports Server (NTRS)

    Dean, John

    1998-01-01

    The main objective of my research has been to incorporate virtual reality at the desktop level; i.e., create virtual reality software that can be run fairly inexpensively on standard PC's. The standard language used for virtual reality on PC's is VRML (Virtual Reality Modeling Language). It is a new language so it is still undergoing a lot of changes. VRML 1.0 came out only a couple years ago and VRML 2.0 came out around last September. VRML is an interpreted language that is run by a web browser plug-in. It is fairly flexible in terms of allowing you to create different shapes and animations. Before this summer, I knew very little about virtual reality and I did not know VRML at all. I learned the VRML language by reading two books and experimenting on a PC. The following topics are presented: CAD to VRML, VRML 1.0 to VRML 2.0, VRML authoring tools, VRML browsers, finding virtual reality applications, the AXAF project, the VRML generator program, web communities and future plans.

  8. PC8 [corrected], a new member of the convertase family.

    PubMed

    Bruzzaniti, A; Goodge, K; Jay, P; Taviaux, S A; Lam, M H; Berta, P; Martin, T J; Moseley, J M; Gillespie, M T

    1996-03-15

    A novel subtilisin-like protein, PC8, was identified by PCR using degenerate primers to conserved amino acid residues in the catalytic region of members of the prohormone convertase family. PC8 was predicted to be 785 residues long and was structurally related to the mammalian convertases furin, PACE4, PC1 and PC2, sharing more than 50% amino acid identity over the catalytic region with these family members. PC8 possessed the catalytically important Asp, His, Asn and Ser amino acids, the homo B domain of this family of enzymes and a C-terminal hydrophobic sequence indicative of a transmembrane domain. Structurally, PC8 is more related to furin and PACE4 than to PC1 or PC2. Like furin and PACE4, PC8 mRNA was found to be widely expressed; this is in contrast with PC1 and PC2, which have a restricted distribution. Two transcripts, of 4.5 and 3.5 kb, were detected in both human cell lines and rat tissues. Unlike furin and PACE4, both of which map to chromosome 15, PC8 maps to chromosome 11q23-11q24, suggesting that this gene may have resulted from an ancient gene duplication event from either furin or PACE4, or conversely that these genes arose from PC8. PMID:8615762

  9. 39 CFR 501.16 - PC postage payment methodology.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DISTRIBUTE POSTAGE EVIDENCING SYSTEMS § 501.16 PC postage payment methodology. (a) The PC Postage customer is... issues a refund to a customer for any unused postage in a Postage Evidencing System. After...

  10. RNA polymerase II cofactor PC2 facilitates activation of transcription by GAL4-AH in vitro.

    PubMed Central

    Kretzschmar, M; Stelzer, G; Roeder, R G; Meisterernst, M

    1994-01-01

    We have isolated from a crude Hela cell cofactor fraction (USA) a novel positive cofactor that cooperates with the general transcription machinery to effect efficient stimulation of transcription by GAL4-AH, a derivative of the Saccharomyces cerevisiae regulatory factor GAL4. PC2 was shown to be a 500-kDa protein complex and to be functionally and biochemically distinct from native TFIID and previously identified cofactors. In the presence of native TFIID and other general factors, PC2 was necessary and sufficient for activation by GAL4-AH. Cofactor function was specific for transcriptional activation domains of GAL4-AH. The repressor histone H1 further potentiated but was not required for activation of transcription by GAL4-AH. On the basis of the observation that PC2 exerts entirely positive effects on transcription, we propose a model in which PC2 increases the activity of the preinitiation complex in the presence of an activator, thereby establishing a specific pathway during activation of RNA polymerase II. Images PMID:8196633

  11. Hysteretic Behavior of Proprotein Convertase 1/3 (PC1/3)

    PubMed Central

    Icimoto, Marcelo Y.; Barros, Nilana M.; Ferreira, Juliana C.; Marcondes, Marcelo F.; Andrade, Douglas; Machado, Mauricio F.; Juliano, Maria A.; Júdice, Wagner A.; Juliano, Luiz; Oliveira, Vitor

    2011-01-01

    The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a lag phase of activation by substrates that can be interpreted as a hysteretic behavior of the enzyme for their hydrolysis. This is an unprecedented observation in peptidases, but is frequent in regulatory enzymes with physiological relevance. The lag phase of mPC1/3 is dependent on substrate, calcium concentration and pH. This hysteretic behavior may have implications in the physiological processes in which PC1/3 participates and could be considered an additional control step in the peptide hormone maturation processes as for instance in the transformation of proinsulin to insulin. PMID:21935423

  12. The USL NASA PC R and D development environment standards

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1984-01-01

    The development environment standards which have been established in order to control usage of the IBM PC/XT development systems and to prevent interference between projects being currently developed on the PC's are discussed. The standards address the following areas: scheduling PC resources; login/logout procedures; training; file naming conventions; hard disk organization; diskette care; backup procedures; and copying policies.

  13. 41 CFR 128-1.5002-8 - Property custodian (PC).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Property custodian (PC... Personal Property Management § 128-1.5002-8 Property custodian (PC). An individual responsible for the... required on all actions affecting the personal property within his jurisdiction. The designation as PC...

  14. 39 CFR 3004.42 - Tracking of requests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Tracking of requests. 3004.42 Section 3004.42 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PUBLIC RECORDS AND FREEDOM OF INFORMATION ACT... that number to the person making the request. (b) Any person with a tracking number may call or...

  15. 39 CFR 3004.42 - Tracking of requests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Tracking of requests. 3004.42 Section 3004.42 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PUBLIC RECORDS AND FREEDOM OF INFORMATION ACT... that number to the person making the request. (b) Any person with a tracking number may call or...

  16. 39 CFR 3004.42 - Tracking of requests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Tracking of requests. 3004.42 Section 3004.42 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PUBLIC RECORDS AND FREEDOM OF INFORMATION ACT... that number to the person making the request. (b) Any person with a tracking number may call or...

  17. On the Right Track.

    ERIC Educational Resources Information Center

    Bieber, Ed

    1983-01-01

    Suggests thinking of "tracks" as clues and using them as the focus of outdoor activities in the urban environment. Provides 24 examples of possible track activities, including: seeds on the ground (track of a nearby tree), litter (track of a litterbug), and peeling paint (track of weathering forces). (JN)

  18. Track Construction Manual.

    ERIC Educational Resources Information Center

    Banke, Ron; Di Gennaro, Guy; Ediger, Rick; Garner, Lanny; Hersom, Steve; Miller, Jack; Nemeth, Ron; Petrucelli, Jim; Sierks, Donna; Smith, Don; Swank, Kevin; West, Kevin

    This book establishes guidelines for the construction and maintenance of tracks by providing information for building new tracks or upgrading existing tracks. Subjects covered include running track planning and construction, physical layout, available surfaces, and maintenance. General track requirements and construction specifications are…

  19. Adaptive DFT-based Interferometer Fringe Tracking

    NASA Technical Reports Server (NTRS)

    Wilson, Edward; Pedretti, Ettore; Bregman, Jesse; Mah, Robert W.; Traub, Wesley A.

    2004-01-01

    An automatic interferometer fringe tracking system has been developed, implemented, and tested at the Infrared Optical Telescope Array (IOTA) observatory at Mt. Hopkins, Arizona. The system can minimize the optical path differences (OPDs) for all three baselines of the Michelson stellar interferometer at IOTA. Based on sliding window discrete Fourier transform (DFT) calculations that were optimized for computational efficiency and robustness to atmospheric disturbances, the algorithm has also been tested extensively on off-line data. Implemented in ANSI C on the 266 MHz PowerPC processor running the VxWorks real-time operating system, the algorithm runs in approximately 2.0 milliseconds per scan (including all three interferograms), using the science camera and piezo scanners to measure and correct the OPDs. The adaptive DFT-based tracking algorithm should be applicable to other systems where there is a need to detect or track a signal with an approximately constant-frequency carrier pulse.

  20. SnPhPc phthalocyanines with dianion Pc(2-) and radical trianion Pc˙(3-) macrocycles: syntheses, structures, and properties.

    PubMed

    Konarev, Dmitri V; Kuzmin, Alexey V; Nakano, Yoshiaki; Khasanov, Salavat S; Ishikawa, Manabu; Otsuka, Akihiro; Yamochi, Hideki; Saito, Gunzi; Lyubovskaya, Rimma N

    2016-06-28

    The interaction of Sn(IV)Cl2Pc with an excess of NaBPh4 in the presence of fullerenes C60 and C70 provides complete dissolution of Sn(IV)Cl2Pc and the formation of blue solutions from which the crystals of [SnPhPc(2-)](+)(BPh4)(-)·C6H14 () or [SnPhPc˙(3-)]·C6H4Cl2 () were selectively isolated. According to the optical spectra, salt contains dianionic Pc(2-) macrocycles, whereas macrocycles are reduced to form the Pc˙(3-) radical trianions in . As a result, the phthalocyanine macrocycle is dianionic in , and the positive charge of Sn(IV) is compensated by the Ph(-), Pc(2-), and BPh4(-) anions in this compound. The formally neutral compound contains two anionic species of Ph(-) and Pc˙(3-) and the Sn(IV) ion as the counter cation. Phenyl substituents are linked to the Sn(IV) atoms by the Sn-C(Ph) bonds of 2.098(2) () and 2.105(2) Å () length. The dianionic Pc(2-) macrocycle significantly deviates from planarity in while Pc˙(3-) is planar in . Salt manifests only a weak impurity EPR signal. Compound manifests an intense EPR signal with g = 2.0046 and a linewidth of 0.5 mT at 298 K due to the presence of Pc˙(3-). Spins are weakly antiferromagnetically coupled in the π-stacking [SnPhPc˙(3-)]2 dimers of with a Weiss temperature of -3 K and the estimated magnetic exchange interaction J/kB = -0.23 K.

  1. SnPhPc phthalocyanines with dianion Pc(2-) and radical trianion Pc˙(3-) macrocycles: syntheses, structures, and properties.

    PubMed

    Konarev, Dmitri V; Kuzmin, Alexey V; Nakano, Yoshiaki; Khasanov, Salavat S; Ishikawa, Manabu; Otsuka, Akihiro; Yamochi, Hideki; Saito, Gunzi; Lyubovskaya, Rimma N

    2016-06-28

    The interaction of Sn(IV)Cl2Pc with an excess of NaBPh4 in the presence of fullerenes C60 and C70 provides complete dissolution of Sn(IV)Cl2Pc and the formation of blue solutions from which the crystals of [SnPhPc(2-)](+)(BPh4)(-)·C6H14 () or [SnPhPc˙(3-)]·C6H4Cl2 () were selectively isolated. According to the optical spectra, salt contains dianionic Pc(2-) macrocycles, whereas macrocycles are reduced to form the Pc˙(3-) radical trianions in . As a result, the phthalocyanine macrocycle is dianionic in , and the positive charge of Sn(IV) is compensated by the Ph(-), Pc(2-), and BPh4(-) anions in this compound. The formally neutral compound contains two anionic species of Ph(-) and Pc˙(3-) and the Sn(IV) ion as the counter cation. Phenyl substituents are linked to the Sn(IV) atoms by the Sn-C(Ph) bonds of 2.098(2) () and 2.105(2) Å () length. The dianionic Pc(2-) macrocycle significantly deviates from planarity in while Pc˙(3-) is planar in . Salt manifests only a weak impurity EPR signal. Compound manifests an intense EPR signal with g = 2.0046 and a linewidth of 0.5 mT at 298 K due to the presence of Pc˙(3-). Spins are weakly antiferromagnetically coupled in the π-stacking [SnPhPc˙(3-)]2 dimers of with a Weiss temperature of -3 K and the estimated magnetic exchange interaction J/kB = -0.23 K. PMID:27295607

  2. PC-based car license plate reader

    NASA Astrophysics Data System (ADS)

    Hwang, Chung-Mu; Shu, Shyh-Yeong; Chen, Wen-Yu; Chen, Yie-Wern; Wen, Kuang-Pu

    1992-11-01

    A car license plate reader (CLPR) using fuzzy inference and neural network algorithm has been developed in Industrial Technology Research Institute (ITRI) and installed in highway toll stations to identify stolen cars. It takes an average of 0.7 seconds to recognize a car license plate by using a PC with 80486-50 CPU. The recognition rate of the system is about 97%. The techniques of CLPR include vehicle sensing, image grab control, optic pre- processing, lighting, and optic character recognition (OCR). The CLPR can be used in vehicle flow statistics, the checking of stolen vehicles, automatic charging systems in parking lots or garage management, and so on.

  3. PC-assisted translation of photogrammetric papers

    NASA Astrophysics Data System (ADS)

    Güthner, Karlheinz; Peipe, Jürgen

    A PC-based system for machine translation of photogrammetric papers from the English into the German language and vice versa is described. The computer-assisted translating process is not intended to create a perfect interpretation of a text but to produce a rough rendering of the content of a paper. Starting with the original text, a continuous data flow is effected into the translated version by means of hardware (scanner, personal computer, printer) and software (OCR, translation, word processing, DTP). An essential component of the system is a photogrammetric microdictionary which is being established at present. It is based on several sources, including e.g. the ISPRS Multilingual Dictionary.

  4. A PC-interactive stereonet plotting program

    NASA Astrophysics Data System (ADS)

    Pilant, Walter L.

    The computer program here described allows the structural geologist to rotate and revolve structural data interactively (strike dip: trend plunge). These actions can remove the effects of dip and plunge. Once a final screen plot is obtained, it may be printed on an associated graphics printer. This program requires an IBM PC/XT AT or compatible equipped with the color graphics (CGA) card. It also works satisfactorily on compatible PCs such as the COMPAQ or AT&T 6300 (which use a combination mono CGA screen). The addition of a math coprocessor (8087 or 80287) greatly speeds up the response time but is not required.

  5. IBM PC/IX operating system evaluation plan

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

    1984-01-01

    An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

  6. Regulatory Anatomy

    PubMed Central

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, legal documents, technological devices, organizational structures, and work practices aimed at minimizing risk. I use this term to reorient the analytical attention with respect to safety regulation. Instead of evaluating whether safety is achieved, the point is to explore the types of “safety” produced through these logics as well as to consider the sometimes unintended consequences of such safety work. In fact, the EU rules have been giving rise to complaints from practitioners finding the directives problematic and inadequate. In this article, I explore the problems practitioners face and why they arise. In short, I expose the regulatory anatomy of the policy landscape. PMID:26139952

  7. Regulatory RNAs

    PubMed Central

    Vazquez-Anderson, Jorge; Contreras, Lydia M

    2013-01-01

    RNAs have many important functional properties, including that they are independently controllable and highly tunable. As a result of these advantageous properties, their use in a myriad of sophisticated devices has been widely explored. Yet, the exploitation of RNAs for synthetic applications is highly dependent on the ability to characterize the many new molecules that continue to be discovered by large-scale sequencing and high-throughput screening techniques. In this review, we present an exhaustive survey of the most recent synthetic bacterial riboswitches and small RNAs while emphasizing their virtues in gene expression management. We also explore the use of these RNA components as building blocks in the RNA synthetic biology toolbox and discuss examples of synthetic RNA components used to rewire bacterial regulatory circuitry. We anticipate that this field will expand its catalog of smart devices by mimicking and manipulating natural RNA mechanisms and functions. PMID:24356572

  8. Regulatory Physiology

    NASA Technical Reports Server (NTRS)

    Lane, Helen W.; Whitson, Peggy A.; Putcha, Lakshmi; Baker, Ellen; Smith, Scott M.; Stewart, Karen; Gretebeck, Randall; Nimmagudda, R. R.; Schoeller, Dale A.; Davis-Street, Janis

    1999-01-01

    As noted elsewhere in this report, a central goal of the Extended Duration Orbiter Medical Project (EDOMP) was to ensure that cardiovascular and muscle function were adequate to perform an emergency egress after 16 days of spaceflight. The goals of the Regulatory Physiology component of the EDOMP were to identify and subsequently ameliorate those biochemical and nutritional factors that deplete physiological reserves or increase risk for disease, and to facilitate the development of effective muscle, exercise, and cardiovascular countermeasures. The component investigations designed to meet these goals focused on biochemical and physiological aspects of nutrition and metabolism, the risk of renal (kidney) stone formation, gastrointestinal function, and sleep in space. Investigations involved both ground-based protocols to validate proposed methods and flight studies to test those methods. Two hardware tests were also completed.

  9. Comparison of Polar Cap (PC) index calculations.

    NASA Astrophysics Data System (ADS)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) index introduced by Troshichev and Andrezen (1985) is derived from polar magnetic variations and is mainly a measure of the intensity of the transpolar ionospheric currents. These currents relate to the polar cap antisunward ionospheric plasma convection driven by the dawn-dusk electric field, which in turn is generated by the interaction of the solar wind with the Earth's magnetosphere. Coefficients to calculate PCN and PCS index values from polar magnetic variations recorded at Thule and Vostok, respectively, have been derived by several different procedures in the past. The first published set of coefficients for Thule was derived by Vennerstrøm, 1991 and is still in use for calculations of PCN index values by DTU Space. Errors in the program used to calculate index values were corrected in 1999 and again in 2001. In 2005 DMI adopted a unified procedure proposed by Troshichev for calculations of the PCN index. Thus there exists 4 different series of PCN index values. Similarly, at AARI three different sets of coefficients have been used to calculate PCS indices in the past. The presentation discusses the principal differences between the various PC index procedures and provides comparisons between index values derived from the same magnetic data sets using the different procedures. Examples from published papers are examined to illustrate the differences.

  10. Evaluating security systems using SNAP-PC

    SciTech Connect

    Tobin, C.D.; Gregg, M.L.; Erdbruegger, M.R.

    1986-08-01

    SNAP-PC (Safeguards Network Analysis Procedure for the Personal Computer) is a user-friendly version of SNAP designed for IBM XT or AT compatible microcomputers. SNAP is a simulation-based analysis technique supporting the evaluation of fixed-site security systems to prevent theft or sabotage of a specified target. Through SNAP the user is able to define the facility, the sensor system, the guard operating policies and response tactics, and the adversary's attack plan. SNAP uses the system definition to analyze its effectiveness in defending against specific threats. The system performance statistics measured by SNAP include: Adversary mission success probability, guard and adversary casualties, duration of engagements, outcome of engagements, duration of scenario by outcome (adversary success/fail), and adversary duration by facility location. The SNAP-PC package provides a compact analysis tool that can be used to analyze a wide variety of security systems. It places SNAP, a proven evaluation technique, in the hands of on-site personnel, not just computer analysts. The support programs eliminate the labor intensive tedious task of organizing and sorting through reams of output reports and greatly reduce the time previously required to analyze a security system.

  11. Motor Proteins at Work in PC12

    NASA Astrophysics Data System (ADS)

    Hill, David; Holzwarth, George; Superfine, Richard

    2003-11-01

    Motor proteins such as kinesin and dynein drive vesicle transport within cells by converting the chemical energy of ATP into mechanical work. As vesicles are transported in PC12 neurites, they travel at constant velocity for long intervals before changing to a different constant velocity. When scaled by the minimum observed velocity of a vesicles, the changes in velocity occur in quantizes intervals of +/- 1, 2, 3 etc. These changes in velocity are caused by a change in the number of motor proteins actively transporting the vesicle. The viscoelastic modulus and viscosity appropriate for large vesicles (0.25 - 0.5 micron radius) in PC12 was determined by measuring the Brownian motion of vesicles within the distal expansions of neurites. The corresponding Stokes' drag on the vesicles was 4.2 +/- 0.6 pN per motor. Assuming that kinesin hydrolyzes 1 ATP per 8 nm step (consistent with in-vitro measurements), the motor's efficiency is 33apply forces in magnetic beeds in the hopes of mimicking vesicle motion.

  12. The Origin of OB Clusters: From 10 pc to 0.1 pc

    NASA Astrophysics Data System (ADS)

    Liu, Hauyu Baobab; Quintana-Lacaci, Guillermo; Wang, Ke; Ho, Paul T. P.; Li, Zhi-Yun; Zhang, Qizhou; Zhang, Zhi-Yu

    2012-01-01

    We observe the 1.2 mm continuum emission around the OB cluster-forming region G10.6-0.4, using the MAMBO-2 bolometer array of the IRAM 30 m telescope and the Submillimeter Array (SMA). Comparison of the Spitzer 24 μm and 8 μm images with our 1.2 mm continuum maps reveal an ionization front of an H II region, the photon-dominated layer, and several 5 pc scale filaments that follow the outer edge of the photon-dominated layer. The filaments, which are resolved in the MAMBO-2 observations, show regularly spaced parsec-scale molecular clumps, embedded with a cluster of dense molecular cores as shown in the SMA 0.87 mm observations. Toward the center of the G10.6-0.4 region, the combined SMA+IRAM 30 m continuum image reveals several parsec-scale protrusions. They may continue down to within 0.1 pc of the geometric center of a dense 3 pc scale structure, where a 200 M ⊙ OB cluster resides. The observed filaments may facilitate mass accretion onto the central cluster-forming region in the presence of strong radiative and mechanical stellar feedback. Their filamentary geometry may also facilitate fragmentation. We did not detect any significant polarized emission at 0.87 mm in the inner 1 pc region with SMA.

  13. PC-based Multiple Information System Interface (PC/MISI) detailed design and implementation plan

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The design plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intended to be used as a blueprint for the implementation of the system. Each component is described in the detail necessary to allow programmers to implement the system. A description of the system data flow and system file structures is given.

  14. METCAN-PC - METAL MATRIX COMPOSITE ANALYZER

    NASA Technical Reports Server (NTRS)

    Murthy, P. L.

    1994-01-01

    High temperature metal matrix composites offer great potential for use in advanced aerospace structural applications. The realization of this potential however, requires concurrent developments in (1) a technology base for fabricating high temperature metal matrix composite structural components, (2) experimental techniques for measuring their thermal and mechanical characteristics, and (3) computational methods to predict their behavior. METCAN (METal matrix Composite ANalyzer) is a computer program developed to predict this behavior. METCAN can be used to computationally simulate the non-linear behavior of high temperature metal matrix composites (HT-MMC), thus allowing the potential payoff for the specific application to be assessed. It provides a comprehensive analysis of composite thermal and mechanical performance. METCAN treats material nonlinearity at the constituent (fiber, matrix, and interphase) level, where the behavior of each constituent is modeled accounting for time-temperature-stress dependence. The composite properties are synthesized from the constituent instantaneous properties by making use of composite micromechanics and macromechanics. Factors which affect the behavior of the composite properties include the fabrication process variables, the fiber and matrix properties, the bonding between the fiber and matrix and/or the properties of the interphase between the fiber and matrix. The METCAN simulation is performed as point-wise analysis and produces composite properties which are readily incorporated into a finite element code to perform a global structural analysis. After the global structural analysis is performed, METCAN decomposes the composite properties back into the localized response at the various levels of the simulation. At this point the constituent properties are updated and the next iteration in the analysis is initiated. This cyclic procedure is referred to as the integrated approach to metal matrix composite analysis. METCAN-PC

  15. Pachyonychia congenita with late onset (PC tarda).

    PubMed

    Sravanthi, A; Srivalli, P; Gopal, K V T; Rao, T Narayana

    2016-01-01

    Pachyonychia congenita is a rare type of ectodermal dysplasia further classified into 4 types. Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis and woolly hair. A 25-year-old male presented to us with thickened nails and scanty scalp hair. On examination, we noticed hyperkeratotic plaques over both the soles, palmoplantar hyperhidrosis and yellowish discoloration, wedging with subungual hyperkeratosis of all the nails. Follicular hyperkeratotic papules and steatocystoma multiplex were also observed over the scalp and face. The patient had history of natal teeth and on dental examination, lower central incisors were absent. All cutaneous changes in our case had manifested first in the 2(nd) decade except for natal teeth. All the above features suggested the diagnosis of pachyonychia congenita with late onset (PC tarda), which is an infrequently reported rare variant. PMID:27559502

  16. Pachyonychia congenita with late onset (PC tarda)

    PubMed Central

    Sravanthi, A.; Srivalli, P.; Gopal, K. V. T.; Rao, T. Narayana

    2016-01-01

    Pachyonychia congenita is a rare type of ectodermal dysplasia further classified into 4 types. Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis and woolly hair. A 25-year-old male presented to us with thickened nails and scanty scalp hair. On examination, we noticed hyperkeratotic plaques over both the soles, palmoplantar hyperhidrosis and yellowish discoloration, wedging with subungual hyperkeratosis of all the nails. Follicular hyperkeratotic papules and steatocystoma multiplex were also observed over the scalp and face. The patient had history of natal teeth and on dental examination, lower central incisors were absent. All cutaneous changes in our case had manifested first in the 2nd decade except for natal teeth. All the above features suggested the diagnosis of pachyonychia congenita with late onset (PC tarda), which is an infrequently reported rare variant. PMID:27559502

  17. Pathway Controlled Penetration (PcP)

    SciTech Connect

    Knight, Earl E.; Rougier, Esteban; Zubelewicz, Aleksander

    2012-08-29

    The technical approach employs advanced computational simulation tools to demonstrate how current assets can destroy RWK-RFI-12-0001's HDBT, a tunnel complex with two portals built into the base of a granite mountain. The granite over layer is assumed to be 60 meters thick over both portals and 80 meters over the facility's mission space. Key S&T is the completed development of a highly innovative viscoplastic fracture material model, 3D parallel gas-fracture capabilities into FDEM, and a stochastic handling of the material properties. Phase I - Develop and validate code simulation tools: (1) develop, incorporate and validate AZ-Frac material model for granite; and (2) Develop and incorporate gas-driven-fracture modeling into LANL's FDEM MUNROU code; (3) Develop and incorporate stochastic features into FDEM modeling. Phase II - Conduct PcP analysis on above HDBT: (1) Acquire HDBT design data, develop simulation model; and (2) Evaluate and select most promising defeat alternative. Phase III - Deliver code, train Service target analysts, and conduct simulations against real world HDBTs. PcP uses advanced computer simulations to enhance HDBT functional defeat efforts. Newly developed material models that account for fractural energy coupled with the finite discrete element methodology (FDEM) will provide targeting packages that will create penetration avenues for current or future lethality options. This novel computational approach requires full 3D geologic and structure characterization as well as significant high performance computing capabilities. The goal is to distinctively alter the targeting paradigm by leveraging critical DoD assets along with insitu geologic strata. In other words, assets will utilize underground rock structure to their benefit by creating rubbilization zones that will allow pathway controlled penetration.

  18. Solar tracking system

    DOEpatents

    Okandan, Murat; Nielson, Gregory N.

    2016-07-12

    Solar tracking systems, as well as methods of using such solar tracking systems, are disclosed. More particularly, embodiments of the solar tracking systems include lateral supports horizontally positioned between uprights to support photovoltaic modules. The lateral supports may be raised and lowered along the uprights or translated to cause the photovoltaic modules to track the moving sun.

  19. The deployment of visual spatial attention during visual search predicts response time: electrophysiological evidence from the N2pc.

    PubMed

    Drisdelle, Brandi L; West, Greg L; Jolicoeur, Pierre

    2016-11-01

    We tracked the deployment of visual spatial attention, as indexed by an electrophysiological event-related potential named the N-2-posterior-contralateral (N2pc). We expected that a stronger and/or earlier deployment of attention would predict faster responses in a visual search task. We tested this hypothesis by sorting the electrophysiological segments into two categories (slow vs. fast) by trial-by-trial response times (RTs), for each participant, on the basis of the median RT within each condition of the experiment. We also classified participants on the basis of overall mean RTs into those faster than the group median and those slower than the group median. The N2pc was larger and earlier for fast responders compared with slow responders. Furthermore, within each of these groups, faster responses were associated with a larger and earlier N2pc. These results provide further evidence that the N2pc is a valid index of the deployment of visual attention, and suggest that a more effective deployment of visual spatial attention (larger and/or earlier N2pc) predicts a faster response, both within and between subjects. PMID:27648715

  20. Expression of PKC iota affects neuronal differentiation of PC12 cells at least partly independent of kinase function

    PubMed Central

    Doonachar, Alana; Schoenfeld, Alan R.

    2014-01-01

    Atypical PKC (aPKC) plays a role in establishing cell polarity and has been indicated in neuronal differentiation and polarization, including neurite formation in rat pheochromocytoma PC12 cells, albeit by unclear mechanisms. Here, the role of the aPKC isoform, PKC iota (PKCι), in the early neuronal differentiation of PC12 cells was investigated. NGF-treated PC12 cells with stably expressed exogenous wild-type PKCι showed decreased expression of a neuroendocrine marker, increased expression of a neuronal marker, and increased neurite formation. Stable expression of a kinase- inactive PKCι, but not constitutively active PKCι lacking a regulatory domain, had similar although less potent effects. Pharmacological inhibition of endogenous aPKC kinase activity in parental PC12 cells did not inhibit neurite formation, suggesting that some of the observed effects of PKCι expression on neuronal differentiation are kinase- independent. Interestingly, exogenous expression of wild-type and kinase-inactive PKCι had little effect on overall PKCι activity, but caused a decrease in PKC zeta (PKCζ) kinase activity, suggesting an interplay between the two isoforms that may underlie the observed results. Overall, these findings suggest that in PC12 and perhaps other neuroendocrine precursor cells, PKCι influences an early differentiation decision between the neuroendocrine (chromaffin) and sympathetic neuron cell lineages, potentially by affecting PKCζ function. PMID:24910851

  1. ELIPGRID-PC: A PC program for calculating hot spot probabilities

    SciTech Connect

    Davidson, J.R.

    1994-10-01

    ELIPGRID-PC, a new personal computer program has been developed to provide easy access to Singer`s 1972 ELIPGRID algorithm for hot-spot detection probabilities. Three features of the program are the ability to determine: (1) the grid size required for specified conditions, (2) the smallest hot spot that can be sampled with a given probability, and (3) the approximate grid size resulting from specified conditions and sampling cost. ELIPGRID-PC also provides probability of hit versus cost data for graphing with spread-sheets or graphics software. The program has been successfully tested using Singer`s published ELIPGRID results. An apparent error in the original ELIPGRID code has been uncovered and an appropriate modification incorporated into the new program.

  2. Further characterization of scrapie replication in PC12 cells.

    PubMed

    Rubenstein, R; Scalici, C L; Papini, M C; Callahan, S M; Carp, R I

    1990-04-01

    The rat pheochromocytoma cell line, PC12, undergoes neuron-like morphological, biochemical and electrophysiological differentiation, in the presence of low concentrations of nerve growth factor (NGF). NGF-treated PC12 cells have been shown previously to support 139A scrapie agent replication. In the present report we extended these findings and analysed the cellular conditions necessary for agent replication. Following the infection of differentiated PC12 cells, scrapie replicated to relatively high titres as determined by an incubation period assay. The removal of NGF, which causes the gradual dedifferentiation of PC12 cells, resulted in the inability of scrapie to replicate. The scrapie infectivity detected in PC12 cultures is cell-associated and not released into the medium. Cells in infected cultures did not show any change in morphology when compared to cells in mock-infected cultures. Titration studies of scrapie infectivity in PC12 cells have indicated that up to 4 LD50 units per cell can be obtained although a yield of 1 LD50 per cell was more common. Using an approximate m.o.i. of 1, only differentiated PC12 cells supported 139A scrapie agent replication when compared to two other differentiated, neuronal cell types, indicating that PC12 cells are more susceptible to agent replication. These studies support further the suitability of using differentiated PC12 cells as an in vitro model to study scrapie agent replication.

  3. Security market reaction to FDA fast track designations.

    PubMed

    Anderson, Christopher W; Zhang, Ying

    2010-01-01

    Pharmaceutical firms can apply for the Food and Drug Administration to 'fast track' research and de velopment on new drugs, accelerating clinical trials and expediting regulatory review required prior to marketing to consumers. We investigate security market reaction to more than 100 fast track designations from 1998 to 2004. Fast track designation appears to enhance investor recognition of firm value. Specifically, fast track designation coincides with abnormal trading volume and excess daily stock returns for sponsoring firms. Institutional ownership and analyst attention also increase. Market response is more pronounced for firms that are smaller, do not yet market products, and have low institutional ownership. PMID:21294437

  4. Hacker tracking Security system for HMI

    NASA Astrophysics Data System (ADS)

    Chauhan, Rajeev Kumar

    2011-12-01

    Conventional Supervisory control and data Acquisition (SCADA) systems use PC, notebook, thin client, and PDA as a Client. Nowadays the Process Industries are following multi shift system that's why multi- client of different category have to work at a single human Machine Interface (HMI). They may hack the HMI Display and change setting of the other client. This paper introduces a Hacker tracking security (HTS) System for HMI. This is developed by using the conventional and Biometric authentication. HTS system is developed by using Numeric passwords, Smart card, biometric, blood flow and Finger temperature. This work is also able to identify the hackers.

  5. Application of PC-ANN and PC-LS-SVM in QSAR of CCR1 antagonist compounds: a comparative study.

    PubMed

    Shahlaei, Mohsen; Fassihi, Afshin; Saghaie, Lotfollah

    2010-04-01

    Principal component regression (PCR), principal component-artificial neural network (PC-ANN), and principal component-least squares-support vector machine (PC-LS-SVM) as regression methods were investigated for building quantitative structure-activity relationships for the prediction of inhibitory activity of some CCR1 antagonists. Nonlinear methods (PC-ANN and PC-LS-SVM) were better than the PCR method considerably in the goodness of fit and predictivity parameters and other criteria for evaluation of the proposed model. These results reflect a nonlinear relationship between the principal components obtained from molecular descriptors and the inhibitory activity of this set of molecules. The maximum variance in activity of the molecules, in PCR method was 45.5%, whereas nonlinear methods, PC-ANN and PC-LS-SVM, could explain more than 93.7% and 95.6% variance in activity data respectively.

  6. Electronic properties of CuPc and H2Pc: an experimental and theoretical study.

    PubMed

    Nardi, Marco Vittorio; Detto, Francesca; Aversa, Lucrezia; Verucchi, Roberto; Salviati, Giancarlo; Iannotta, Salvatore; Casarin, Maurizio

    2013-08-21

    Phthalocyanine (H2Pc) and its open-shell copper complex (CuPc) deposited on amorphous gold films have been studied by combining the outcomes of several synchrotron based spectroscopic tools (X-ray photoelectron spectroscopy, UV photoelectron spectroscopy and near-edge X-ray absorption fine structure, NEXAFS, spectroscopy) with those of density functional theory (DFT) calculations. The assignment of experimental evidence has been guided by the results of DFT numerical experiments carried out on isolated molecules. With specific reference to CuPc NEXAFS data collected at the N K-edge, they have been assigned by using the open-shell time-dependent DFT (TDDFT) in the framework of the zeroth order regular approximation (ZORA) scalar relativistic approach. The agreement between theory and experiment has been found to be satisfactory, thus indicating that the open-shell TDDFT (F. Wang and T. Ziegler, Mol. Phys., 2004, 102, 2585) may be used with some confidence to look into the X-ray absorption spectroscopy results pertinent to transition metal complexes. As far as the metal-ligand interaction is concerned, the combined use of NEXAFS spectroscopy and DFT outcomes ultimately testified the significant ionic contribution characterizing the bonding between the metal centre and the nitrogen atoms of the phthalocyanine coordinative pocket.

  7. TrackEye tracking algorithm characterization

    NASA Astrophysics Data System (ADS)

    Valley, Michael T.; Shields, Robert W.; Reed, Jack M.

    2004-10-01

    TrackEye is a film digitization and target tracking system that offers the potential for quantitatively measuring the dynamic state variables (e.g., absolute and relative position, orientation, linear and angular velocity/acceleration, spin rate, trajectory, angle of attack, etc.) for moving objects using captured single or dual view image sequences. At the heart of the system is a set of tracking algorithms that automatically find and quantify the location of user selected image details such as natural test article features or passive fiducials that have been applied to cooperative test articles. This image position data is converted into real world coordinates and rates with user specified information such as the image scale and frame rate. Though tracking methods such as correlation algorithms are typically robust by nature, the accuracy and suitability of each TrackEye tracking algorithm is in general unknown even under good imaging conditions. The challenges of optimal algorithm selection and algorithm performance/measurement uncertainty are even more significant for long range tracking of high-speed targets where temporally varying atmospheric effects degrade the imagery. This paper will present the preliminary results from a controlled test sequence used to characterize the performance of the TrackEye tracking algorithm suite.

  8. Inhibition of Prohormone Convertases PC1/3 and PC2 by 2,5-Dideoxystreptamine Derivatives

    PubMed Central

    Vivoli, Mirella; Caulfield, Thomas R.; Martínez-Mayorga, Karina; Johnson, Alan T.; Jiao, Guan-Sheng

    2012-01-01

    The prohormone convertases PC1/3 and PC2 are eukaryotic serine proteases involved in the proteolytic maturation of peptide hormone precursors and are implicated in a variety of pathological conditions, including obesity, diabetes, and neurodegenerative diseases. In this work, we screened 45 compounds obtained by derivatization of a 2,5-dideoxystreptamine scaffold with guanidinyl and aryl substitutions for convertase inhibition. We identified four promising PC1/3 competitive inhibitors and three PC2 inhibitors that exhibited various inhibition mechanisms (competitive, noncompetitive, and mixed), with sub- and low micromolar inhibitory potency against a fluorogenic substrate. Low micromolar concentrations of certain compounds blocked the processing of the physiological substrate proglucagon. The best PC2 inhibitor effectively inhibited glucagon synthesis, a known PC2-mediated process, in a pancreatic cell line; no cytotoxicity was observed. We also identified compounds that were able to stimulate both 87 kDa PC1/3 and PC2 activity, behavior related to the presence of aryl groups on the dideoxystreptamine scaffold. By contrast, inhibitory activity was associated with the presence of guanidinyl groups. Molecular modeling revealed interactions of the PC1/3 inhibitors with the active site that suggest structural modifications to further enhance potency. In support of kinetic data suggesting that PC2 inhibition probably occurs via an allosteric mechanism, we identified several possible allosteric binding sites using computational searches. It is noteworthy that one compound was found to both inhibit PC2 and stimulate PC1/3. Because glucagon acts in functional opposition to insulin in blood glucose homeostasis, blocking glucagon formation and enhancing proinsulin cleavage with a single compound could represent an attractive therapeutic approach in diabetes. PMID:22169851

  9. Sled tracking system

    NASA Astrophysics Data System (ADS)

    Downey, George A., Jr.; Fountain, Hubert W.; Riding, Thomas J.; Eggleston, James; Hopkins, Michael; Adams, Billy

    1991-08-01

    The Sled Tracking System (STS) represents the successful merger of several technologies, including IR and visual sensors, real-time image processing, and real-time data processing and control. STS was developed to solve the dynamics of tracking seat ejection and vehicle tests at the Air Force's High Speed Test Track Facility at Holloman AFB, New Mexico. The system has the ability to track vehicles at transverse speeds exceeding Mach 1, while ignoring momentary loss of track due to background clutter. STS can discriminate among up to four seats sequentially ejected from a single vehicle and track only the event of interest. The system also maintains the track point of interest in the primary sensor's field-of-view while tracking an offset aim point and transitions from a transverse trajectory to a vertical trajectory while maintaining track through seat-mannequin separation and chute deployment. This paper discusses the hardware and software architectures implemented to solve these problems.

  10. Can we track holes?

    PubMed Central

    Horowitz, Todd S.; Kuzmova, Yoana

    2011-01-01

    The evidence is mixed as to whether the visual system treats objects and holes differently. We used a multiple object tracking task to test the hypothesis that figural objects are easier to track than holes. Observers tracked four of eight items (holes or objects). We used an adaptive algorithm to estimate the speed allowing 75% tracking accuracy. In Experiments 1–5, the distinction between holes and figures was accomplished by pictorial cues, while red-cyan anaglyphs were used to provide the illusion of depth in Experiment 6. We variously used Gaussian pixel noise, photographic scenes, or synthetic textures as backgrounds. Tracking was more difficult when a complex background was visible, as opposed to a blank background. Tracking was easier when disks carried fixed, unique markings. When these factors were controlled for, tracking holes was no more difficult than tracking figures, suggesting that they are equivalent stimuli for tracking purposes. PMID:21334361

  11. NASA's Agency-wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Duda, Kristen; Scroggins. Sharon

    2008-01-01

    NASA's mission is to pioneer the future in space exploration, scientific discovery, and aeronautics research. To help enable existing and future programs to pursue this mission, NASA has established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) to proactively identify, analyze, and communicate environmental regulatory risks to the NASA community. The RRAC PC is chartered to evaluate the risks posed to NASA Programs and facilities by environmentally related drivers. The RRAC PC focuses on emerging environmental regulations, as well as risks related to operational changes that can trigger existing environmental requirements. Changing regulations have the potential to directly affect program activities. For example, regulatory changes can restrict certain activities or operations by mandating changes in how operations may be done or limiting where or how certain operations can take place. Regulatory changes also can directly affect the ability to use certain materials by mandating a production phase-out or restricting usage aPi'iications of certain materials. Such changes can result in NASA undertaking material replacement efforts. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented several strategies for proactively managing regulatory change to minimize potential adverse impacts to NASA Programs and facilities. This presentation highlights the lessons learned through establishing the RRAC PC, the process by which the RRAC PC monitors and distributes information about emerging regulatory requirements, and the cross

  12. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Duda, Kristen; Scroggins, Sharon

    2008-01-01

    NASA's mission is to pioneer the future in space exploration, scientific discovery, and aeronautics research. To help enable existing and future programs to pursue this mission, NASA has established the Principal Center for Regulatory Risk Analysis and Communication (RRAC PC) to proactively identify, analyze, and communicate environmental regulatory risks to the NASA community. The RRAC PC is chartered to evaluate the risks posed to NASA Programs and facilities by environmentally related drivers. The RRAC PC focuses on emerging environmental regulations, as well as risks related to operational changes that can trigger existing environmental requirements. Changing regulations have the potential to directly affect program activities. For example, regulatory changes can restrict certain activities or operations by mandating changes in how operations may be done or limiting where or how certain operations can take place. Regulatory changes also can directly affect the ability to use certain materials by mandating a production phase-out or restricting usage applications of certain materials. Such changes can result in NASA undertaking material replacement efforts. Even if a regulation does not directly affect NASA operations, U.S. and international regulations can pose program risks indirectly through requirements levied on manufacturers and vendors of components and materials. For example, manufacturers can change their formulations to comply with new regulatory requirements. Such changes can require time-consuming and costly requalification certification for use in human spaceflight programs. The RRAC PC has implemented several strategies for proactively managing regulatory change to minimize potential adverse impacts to NASA Programs and facilities. This presentation highlights the lessons learned through establishing the RRAC PC, the process by which the RRAC PC monitors and distributes information about emerging regulatory requirements, and the cross

  13. To Track or Not to Track?

    ERIC Educational Resources Information Center

    Hesson, Heather

    2010-01-01

    Background: This paper was written for a graduate level action research course at Muskingum University, located in New Concord, OH. Purpose: The purpose of this research was to determine which method of instruction best serves ALL high school students. Is it more advantageous to track ("ability group") students or not to track students in high…

  14. Pulsating proton aurora caused by rising tone Pc1 waves

    NASA Astrophysics Data System (ADS)

    Nomura, R.; Shiokawa, K.; Omura, Y.; Ebihara, Y.; Miyoshi, Y.; Sakaguchi, K.; Otsuka, Y.; Connors, M.

    2016-02-01

    We found rising tone emissions with a dispersion of ˜1 Hz per several tens of seconds in the dynamic spectrum of a Pc1 geomagnetic pulsation (Pc1) observed on the ground. These Pc1 rising tones were successively observed over ˜30 min from 0250 UT on 14 October 2006 by an induction magnetometer at Athabasca, Canada (54.7°N, 246.7°E, magnetic latitude 61.7°N). Simultaneously, a Time History of Events and Macroscale Interactions during Substorms panchromatic (THEMIS) all-sky camera detected pulsations of an isolated proton aurora with a period of several tens of seconds, ˜10% variations in intensity, and fine structures of 3° in magnetic longitudes. The pulsations of the proton aurora close to the zenith of ATH have one-to-one correspondences with the Pc1 rising tones. This suggests that these rising tones scatter magnetospheric protons intermittently at the equatorial region. The radial motion of the magnetospheric source, of which the isolated proton aurora is a projection, can explain the central frequency increase of Pc1, but not the shorter period (tens of seconds) frequency increase of ˜1 Hz in Pc1 rising tones. We suggest that EMIC-triggered emissions generate the frequency increase of Pc1 rising tones on the ground and that they also cause the Pc1 pearl structure, which has a similar characteristic time.

  15. Pc1 propagation in the ionospheric duct: wave vector determination

    NASA Astrophysics Data System (ADS)

    Nomura, Reiko; Glassmeier, Karl-Heinz; Narita, Yasuhito; Plaschke, Fedinand; Mann, Ian

    2013-04-01

    Pc1 geomagnetic pulsations (Pc1) are believed to propagate as fast mode waves in the ionospheric duct. Previous studies tried to locate the Pc1 source region with different methods using the characteristics of the ionospheric duct propagation (e.g., polarization method and amplitude distributions). However, no observational study of the wave vectors and the dispersion relations in the Pc1 source region has been compared with the results estimated from model calculations of the Pc1 ionospheic duct propagation. We have investigated propagation directions of Pc1 pulsations in the ionospheric duct with the 2D Wave Telescope technique. For our study, we used ground-based measurements of Pc1 pulsations from 27 May 2011, observed at 17 different stations of the Canadian magnetometer network CARISMA (www.carisma.ca). These multi-point measurements allow to derive detailed information directly on the wave propagation directions. We also show the dispersion relation of the Pc1 pulsations in the ionospheric duct.

  16. PrPC from stem cells to cancer

    PubMed Central

    Martin-Lannerée, Séverine; Hirsch, Théo Z.; Hernandez-Rapp, Julia; Halliez, Sophie; Vilotte, Jean-Luc; Launay, Jean-Marie; Mouillet-Richard, Sophie

    2014-01-01

    The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knockout animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumors. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumor-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression. PMID:25364760

  17. Transforming PC Power Supplies into Smart Car Battery Conditioners

    ERIC Educational Resources Information Center

    Rodriguez-Ascariz, J. M.; Boquete-Vazquez, L.

    2011-01-01

    This paper describes a laboratory project consisting of a PC power supply modification into an intelligent car-battery conditioner with both wireless and wired networking capabilities. Adding a microcontroller to an average PC power supply transforms it into a flexible, intelligent device that can be configured and that is suitable to keep car…

  18. Hydrogen bonds in PC{sub 61}BM solids

    SciTech Connect

    Sheng, Chun-Qi; Li, Wen-Jie; Du, Ying-Ying; Chen, Guang-Hua; Chen, Zheng; Li, Hai-Yang; Li, Hong-Nian

    2015-09-15

    We have studied the hydrogen bonds in PC{sub 61}BM solids. Inter-molecular interaction is analyzed theoretically for the well-defined monoclinic (P2{sub 1}/n) structure. The results indicate that PC{sub 61}BM combines into C–H⋯O{sub d} bonded molecular chains, where O{sub d} denotes the doubly-bonded O atom of PC{sub 61}BM. The molecular chains are linked together by C–H⋯O{sub s} bonds, where O{sub s} denotes the singly-bonded O atom of PC{sub 61}BM. To reveal the consequences of hydrogen bond formation on the structural properties of PC{sub 61}BM solids (not limited to the monoclinic structure), we design and perform some experiments for annealed samples with the monoclinic (P2{sub 1}/n) PC{sub 61}BM as starting material. The experiments include differential scanning calorimetry, X-ray diffraction and infrared absorption measurements. Structural phase transitions are observed below the melting point. The C–H⋯O{sub d} bonds seem persisting in the altered structures. The inter-molecular hydrogen bonds can help to understand the phase separation in polymer/PC{sub 61}BM blends and may be responsible for the existence of liquid PC{sub 61}BM.

  19. Monte Carlo tests of the ELIPGRID-PC algorithm

    SciTech Connect

    Davidson, J.R.

    1995-04-01

    The standard tool for calculating the probability of detecting pockets of contamination called hot spots has been the ELIPGRID computer code of Singer and Wickman. The ELIPGRID-PC program has recently made this algorithm available for an IBM{reg_sign} PC. However, no known independent validation of the ELIPGRID algorithm exists. This document describes a Monte Carlo simulation-based validation of a modified version of the ELIPGRID-PC code. The modified ELIPGRID-PC code is shown to match Monte Carlo-calculated hot-spot detection probabilities to within {plus_minus}0.5% for 319 out of 320 test cases. The one exception, a very thin elliptical hot spot located within a rectangular sampling grid, differed from the Monte Carlo-calculated probability by about 1%. These results provide confidence in the ability of the modified ELIPGRID-PC code to accurately predict hot-spot detection probabilities within an acceptable range of error.

  20. PC-SEAPAK - ANALYSIS OF COASTAL ZONE COLOR SCANNER AND ADVANCED VERY HIGH RESOLUTION RADIOMETER DATA

    NASA Technical Reports Server (NTRS)

    Mcclain, C. R.

    1994-01-01

    incompatibilities between the MVP-AT image board and ZENITH computers. Also, the MVP-AT image board is not necessarily compatible with 486-based systems; users of 486-based systems should consult with Matrox about compatibility concerns. Other PC-SEAPAK requirements include a Microsoft mouse (serial version), 2Mb RAM, and 100Mb hard disk space. For data ingest and backup, 9-track tape, 8mm tape and optical disks are supported and recommended. PC-SEAPAK has been under development since 1988. Version 4.0 was updated in 1992, and is distributed without source code. It is available only as a set of 36 1.2Mb 5.25 inch IBM MS-DOS format diskettes. PC-SEAPAK is a copyrighted product with all copyright vested in the National Aeronautics and Space Administration. Phar Lap's DOS_Extender run-time version is integrated into several of the programs; therefore, the PC-SEAPAK programs may not be duplicated. Three of the distribution diskettes contain DOS_Extender files. One of the distribution diskettes contains Media Cybernetics' HALO88 font files, also licensed by NASA for dissemination but not duplication. IBM is a registered trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. HALO88 is a registered trademark of Media Cybernetics, but the product was discontinued in 1991.

  1. PC viruses: How do they do that

    SciTech Connect

    Pichnarczyk, K.

    1992-07-01

    The topic of PC Viruses has been an issue for a number of years now. They've been reported in every major newspaper, tabloids, television and radio. People from all fields get viruses: government, private sector businesses, home computers, schools, computer software suppliers. A definition is proposed to introduce the virus phenomenon. Virus authors come from a variety of communities. Motives and ideologies of authors are discussed, and examples of viruses are offered. Also mentioned is the growing number of viruses developed, isolated, and never distributed to the public at large, but kept within the antivirus research community. Virus examples are offered as well. Viruses are distributed not only through bulletin boards and shareware, but also from areas previously assumed to be safe, including the threat of receiving a virus through a standard in-house function, such as an in-house hardware maintenance shop. Three categories of viruses are presented: File Infecter viruses, Boot Sector Infecters, and the new category of Directory Entry Infecter virus. Also discussed are crossover viruses, that is, viruses which utilize a variety of techniques to ensure survival. An explanation of what is occurring within every stage of various viruses is given. Replication strategies common to all three types is noted, mainly the two different replication strategies of memory resident infecters and active selection infecters. A detailed definition, description and application of a stealth virus is presented. Detection strategies are discussed as each topic in this section is completed; a high level schemata of the operation of various virus detection programs ispresented. Since most eradication today is done using virus detection/eradication software, this paper attempts to reveal the techniques used by these packages.Included in the paper is the topic of manual eradication.

  2. PC viruses: How do they do that?

    SciTech Connect

    Pichnarczyk, K.

    1992-07-01

    The topic of PC Viruses has been an issue for a number of years now. They`ve been reported in every major newspaper, tabloids, television and radio. People from all fields get viruses: government, private sector businesses, home computers, schools, computer software suppliers. A definition is proposed to introduce the virus phenomenon. Virus authors come from a variety of communities. Motives and ideologies of authors are discussed, and examples of viruses are offered. Also mentioned is the growing number of viruses developed, isolated, and never distributed to the public at large, but kept within the antivirus research community. Virus examples are offered as well. Viruses are distributed not only through bulletin boards and shareware, but also from areas previously assumed to be safe, including the threat of receiving a virus through a standard in-house function, such as an in-house hardware maintenance shop. Three categories of viruses are presented: File Infecter viruses, Boot Sector Infecters, and the new category of Directory Entry Infecter virus. Also discussed are crossover viruses, that is, viruses which utilize a variety of techniques to ensure survival. An explanation of what is occurring within every stage of various viruses is given. Replication strategies common to all three types is noted, mainly the two different replication strategies of memory resident infecters and active selection infecters. A detailed definition, description and application of a stealth virus is presented. Detection strategies are discussed as each topic in this section is completed; a high level schemata of the operation of various virus detection programs ispresented. Since most eradication today is done using virus detection/eradication software, this paper attempts to reveal the techniques used by these packages.Included in the paper is the topic of manual eradication.

  3. HOTSPOT Health Physics codes for the PC

    SciTech Connect

    Homann, S.G.

    1994-03-01

    The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculation tool for evaluating accidents involving radioactive materials. HOTSPOT codes are a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. HOTSPOT programs are reasonably accurate for a timely initial assessment. More importantly, HOTSPOT codes produce a consistent output for the same input assumptions and minimize the probability of errors associated with reading a graph incorrectly or scaling a universal nomogram during an emergency. The HOTSPOT codes are designed for short-term (less than 24 hours) release durations. Users requiring radiological release consequences for release scenarios over a longer time period, e.g., annual windrose data, are directed to such long-term models as CAPP88-PC (Parks, 1992). Users requiring more sophisticated modeling capabilities, e.g., complex terrain; multi-location real-time wind field data; etc., are directed to such capabilities as the Department of Energy`s ARAC computer codes (Sullivan, 1993). Four general programs -- Plume, Explosion, Fire, and Resuspension -- calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosive release, fuel fire, or an area contamination event. Other programs deal with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. Additional programs estimate the dose commitment from the inhalation of any one of the radionuclides listed in the database of radionuclides; calibrate a radiation survey instrument for ground-survey measurements; and screen plutonium uptake in the lung (see FIDLER Calibration and LUNG Screening sections).

  4. Run-09 pC polarimeter analysis

    SciTech Connect

    Alekseev, I.; Aschenauer, E.; Atoyan, G.; Bazilevsky, A.; Gill, R.; Huang, H.; Lee, S.; Li, X.; Makdisi, Y.; Morozov, B.; Nakagawa, I.; Svirida, D.; Zelenski, A.

    2010-08-01

    Analysis of PC polarimeter data at {radical}s = 200 and 500 GeV from Run9 is presented. Final polarization results, fill-by-fill, for blue and yellow beams, as to be used by RHIC experiments (in collisions) are released and collected in http://www4.rcf.bnl.gov/cnipol/pubdocs/Run09Offline/. Global relative systematic uncertainties {delta}P/P (to be considered as correlated from fill to fill) are 4.7% for 100 GeV beams, and 8.3% (12.1%) for blue (yellow) 250 GeV beams. For a product of two beam polarizations P{sub B} {center_dot} P{sub Y} (used in double spin asymmetry measurements) the relative uncertainty {delta}(P{sub B} {center_dot} P{sub Y})/(P{sub B} {center_dot} P{sub Y}) 8.8% for 100 GeV beams and 18.5% for 250 GeV beams. For the average between two beam polarization (P{sub B} + P{sub Y})/2 (used in single spin asymmetry measurements, when data from two polarized beams are combined) the relative uncertainty is 4.4% for 100 GeV beams and 9.2% for 250 GeV beams. Larger uncertainties for 250 GeV beams relate to significant rate related systematic effects experienced in the first part of Run9 (due to thicker targets used and smaller trans. beam size at higher beam energy).

  5. Scanning tunneling microscopy investigation of self-assembled CuPc/F16CuPc binary superstructures on graphite.

    PubMed

    Huang, Yu Li; Li, Hui; Ma, Jing; Huang, Han; Chen, Wei; Wee, Andrew T S

    2010-03-01

    The self-assembly of the binary molecular system comprising copper(II) phthalocyanine (CuPc) and copper-hexadecafluoro-phthalocyanine (F(16)CuPc) on graphite has been investigated by in situ low-temperature scanning tunneling microscopy (LT-STM). The adsorption of this binary molecular system on graphite results in the formation of a well-ordered chessboardlike nanopattern. The in-plane molecular orientation of the guest CuPc molecules can be tuned by varying the coverage. At low coverage, the sparse CuPc molecules are randomly embedded in the host F(16)CuPc monolayer, possessing two different in-plane orientations; as the CuPc coverage increases, the in-plane molecular orientations of CuPc and F(16)CuPc become unidirectional and a highly ordered chessboardlike pattern forms. Molecular dynamic (MD) simulation results suggest that the selective and directional intermolecular hydrogen bonding determines the in-plane molecular orientation as well as the supramolecular packing arrangement.

  6. Photographing Track Meets.

    ERIC Educational Resources Information Center

    Palmer, Erik

    2001-01-01

    Argues that the sport of track and field, because of the sport itself and its relatively easy access to photographers, is an obvious target for cameras. Discusses rules of the track that photographers must follow; picking a location; and equipment. Discusses shooting four specific track and field events and offers behind the scenes photos. (SR)

  7. Solar tracking apparatus

    DOEpatents

    Hammons, Burrell E.

    1980-01-01

    The invention relates to a solar tracking device which tracks the position of the sun using paired, partially-shaded photocells. Auxiliary photocells are used for initial acquisition of the sun and for the suppression of false tracking when the sun is obscured by clouds.

  8. Solar tracking apparatus

    DOEpatents

    Hammons, B.E.

    The invention relates to a solar tracking device which tracks the position of the sun using paired, partially-shaded photocells. Auxilliary photocells are used for initial acquisition of the sun and for the suppression of false tracking when the sun is obscured by clouds.

  9. Finite resolution multitarget tracking

    NASA Astrophysics Data System (ADS)

    Mušicki, Darko; Morelande, Mark R.

    2005-09-01

    Target tracking algorithms have to operate in an environment of uncertain measurement origin, due to the presence of randomly detected target measurements as well as clutter measurements from unwanted random scatterers. A majority of Bayesian multi-target tracking algorithms suffer from computational complexity which is exponential in the number of tracks and the number of shared measurements. The Linear Multi-target (LM) tracking procedure is a Bayesian multi-target tracking approximation with complexity which is linear in the number of tracks and the number of shared measurements. It also has a much simpler structure than the "optimal" Bayesian multi-target tracking, with apparently negligible decrease in performance. A vast majority of target tracking algorithms have been developed with the assumption of infinite sensor resolution, where a measurement can have only one source. This assumption is not valid for real sensors, such as radars. This paper presents a multi-target tracking algorithm which removes this restriction. The procedure utilizes a simple structure of LM tracking procedure to obtain a LM Finite Resolution (LMfr) tracking procedure which is much simpler than the previously published efforts. Instead of calculating the probability of measurement merging for each combination of potentially merging targets, we evaluate only one merging hypotheses for each measurement and each track. A simulation study is presented which compares LMfr-IPDA with LM-IPDA and IPDA target tracking in a cluttered environment utilizing a finite resolution sensor with five crossing targets. The study concentrates on the false track discrimination performance and the track retention capabilities.

  10. Two-dimensional particle displacement tracking in particle imaging velocimetry

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.

    1991-01-01

    A new particle imaging velocimetry data acquisition and analysis system, which is an order of magnitude faster than any previously proposed system, has been constructed and tested. The new particle displacement tracking (PDT) system is an all electronic technique employing a video camera and a large memory buffer frame-grabber board. Using a simple encoding scheme, a time sequence of single exposure images is time-coded into a single image and then processed to track particle displacements and determine two-dimensional velocity vectors. Use of the PDT technique in a counterrotating vortex flow produced over 1100 velocity vectors in 110 s when processed on an 80386 PC.

  11. ISTUM PC: industrial sector technology use model for the IBM-PC

    SciTech Connect

    Roop, J.M.; Kaplan, D.T.

    1984-09-01

    A project to improve and enhance the Industrial Sector Technology Use Model (ISTUM) was originated in the summer of 1983. The project had dix identifiable objectives: update the data base; improve run-time efficiency; revise the reference base case; conduct case studies; provide technical and promotional seminars; and organize a service bureau. This interim report describes which of these objectives have been met and which tasks remain to be completed. The most dramatic achievement has been in the area of run-time efficiency. From a model that required a large proportion of the total resources of a mainframe computer and a great deal of effort to operate, the current version of the model (ISTUM-PC) runs on an IBM Personal Computer. The reorganization required for the model to run on a PC has additional advantages: the modular programs are somewhat easier to understand and the data base is more accessible and easier to use. A simple description of the logic of the model is given in this report. To generate the necessary funds for completion of the model, a multiclient project is proposed. This project will extend the industry coverage to all the industrial sectors, including the construction of process flow models for chemicals and petroleum refining. The project will also calibrate this model to historical data and construct a base case and alternative scenarios. The model will be delivered to clients and training provided. 2 references, 4 figures, 3 tables.

  12. Stochastic simulation of pulverized coal (PC) processes

    SciTech Connect

    Salazar, J.; Diwekar, U.; Zitney, S.

    2010-01-01

    An increasing population and electricity demand in the U.S. require capacity expansion of power systems. The National Energy Technology Laboratory (NETL), U.S. Department of Energy (DOE), has invested considerable efforts on research and development to improve the design and simulation of these power plants. Incorporation of novel process synthesis techniques and realistic simulation methodologies yield optimal flowsheet configurations and accurate estimation of their performance parameters. To provide a better estimation of such performance indicators, simulation models should predict the process behavior based on not only deterministic values of well-known input parameters but also uncertain variables associated with simulation assumptions. In this work, the stochastic simulation of a load-following pulverized coal (PC) power plant takes into account the variation of three input variables, namely, atmospheric air temperature, atmospheric air humidity, and generation load. These uncertain variables are characterized with probability density functions (pdfs) obtained from available atmospheric and electrical energy generation data. The stochastic simulation is carried out by obtaining a sample of values from the pdfs that generates a set of scenarios under which the model is run. An efficient sampling technique [Hammersley sequence sampling (HSS)] guarantees a set of scenarios uniformly distributed throughout the uncertain variable range. Then, each model run generates results on performance parameters as cycle efficiency, carbon emissions, sulfur emissions, and water consumption that are statistically analyzed after all runs are completed. Among these parameters, water consumption is of importance because an increasing demand has been observed mostly in arid regions of the country and, therefore, constrains the operability of the processes. This water consumption is significantly affected by atmospheric uncertainties. The original deterministic process model

  13. Tracking and Reconstructing the Interdecadal Pacific Oscillation

    NASA Astrophysics Data System (ADS)

    Henley, Benjamin; Gergis, Joelle; Karoly, David

    2015-04-01

    A new index is developed for the Interdecadal Pacific Oscillation, termed the IPO Tripole Index (TPI). The IPO is associated with a distinct 'tripole' pattern of sea surface temperature anomalies (SSTA), with three large centres of action and variations on decadal timescales, evident in the second principal component (PC) of low-pass filtered global SST. The new index is based on the difference between the SSTA averaged over the central equatorial Pacific and the average of the SSTA in the Northwest and Southwest Pacific. The TPI is an easily calculated, non-PC based index for tracking decadal SST variability associated with the IPO. The TPI time series bears a close resemblance to previously published PC-based indices and has the advantages of being simpler to compute and more consistent with methods used to track the El Niño-Southern Oscillation (ENSO), such as the Niño 3.4 and Trans Niño Indices. The TPI also provides a simple metric, with physical units of °C, for evaluating decadal and interdecadal variability of SST fields in a straightforward manner, and can be used to evaluate the skill of dynamical decadal prediction systems. Composites of SST and mean sea level pressure anomalies reveal that the IPO has maintained a broadly stable structure across the seven most recent positive and negative epochs that occurred during 1870-2013. The TPI is shown to be a robust and stable representation of the IPO phenomenon in instrumental records, with relatively more variance in decadal than shorter timescales compared to Niño 3.4, due to the explicit inclusion of off-equatorial SST variability associated with the IPO. This presentation will also report on progress towards developing a new multi-proxy reconstruction of the IPO over the last several centuries, along with an assessment of the TPI in climate models.

  14. Object tracking with stereo vision

    NASA Technical Reports Server (NTRS)

    Huber, Eric

    1994-01-01

    A real-time active stereo vision system incorporating gaze control and task directed vision is described. Emphasis is placed on object tracking and object size and shape determination. Techniques include motion-centroid tracking, depth tracking, and contour tracking.

  15. Single-event upset in advanced PowerPC microprocessors

    NASA Technical Reports Server (NTRS)

    Irom, F.; Swift, G. M.; Farmanesh, F.; Millward, D. G.

    2002-01-01

    Proton and heavy-ion single-event upset susceptibility has been measured for the MotorolaPowerPC7400. The results show that this advanced device has low upset susceptibility, despite the scaling and design advances.

  16. Present (unified) and past Polar Cap (PC) index calculations.

    NASA Astrophysics Data System (ADS)

    Stauning, Peter; Troshichev, Oleg; Janzhura, Alexander

    2010-05-01

    The Polar Cap (PC) index was introduced by Troshichev and Andrezen (1985). Index values are derived from polar cap magnetic variations and are mainly related to the intensity of the variable transpolar ionospheric currents. These currents relate to the polar cap antisunward ionospheric plasma convection driven by the dawn-dusk electric field, which in turn is generated by the interaction of the solar wind with the Earth's magnetosphere. Thus the PC index is an important Space Weather parameter. Coefficients to calculate PC index values from polar magnetic variations have been derived by several different procedures in the past. Now, a unified procedure (Troshichev et al., 2005) has been adopted for both the PCN (north) and the PCS (south) index values. The presentation outlines and discusses the principles and the details of the unified procedure, which will be submitted to IAGA for formal approval. The PC index can be made available on-line in real-time for Space Weather applications.

  17. PC-SPES (PDQ®)—Patient Version

    Cancer.gov

    Expert-reviewed information summary about the use of PC-SPES as a treatment for prostate cancer. Note: The information in this summary is no longer being updated and is provided for reference purposes only.

  18. OCEAN-PC and a distributed network for ocean data

    NASA Technical Reports Server (NTRS)

    Mclain, Douglas R.

    1992-01-01

    The Intergovernmental Oceanographic Commission (IOC) wishes to develop an integrated software package for oceanographic data entry and access in developing countries. The software, called 'OCEAN-PC', would run on low cost PC microcomputers and would encourage and standardize: (1) entry of local ocean observations; (2) quality control of the local data; (3) merging local data with historical data; (4) improved display and analysis of the merged data; and (5) international data exchange. OCEAN-PC will link existing MS-DOS oceanographic programs and data sets with table-driven format conversions. Since many ocean data sets are now being distributed on optical discs (Compact Discs - Read Only Memory, CD-ROM, Mass et al. 1987), OCEAN-PC will emphasize access to CD-ROMs.

  19. PC-SPES (PDQ®)—Health Professional Version

    Cancer.gov

    Expert-reviewed information summary about the use of PC-SPES as a treatment for prostate cancer. Note: The information in this summary is no longer being updated and is provided for reference purposes only.

  20. Tracking dynamic team activity

    SciTech Connect

    Tambe, M.

    1996-12-31

    AI researchers are striving to build complex multi-agent worlds with intended applications ranging from the RoboCup robotic soccer tournaments, to interactive virtual theatre, to large-scale real-world battlefield simulations. Agent tracking - monitoring other agent`s actions and inferring their higher-level goals and intentions - is a central requirement in such worlds. While previous work has mostly focused on tracking individual agents, this paper goes beyond by focusing on agent teams. Team tracking poses the challenge of tracking a team`s joint goals and plans. Dynamic, real-time environments add to the challenge, as ambiguities have to be resolved in real-time. The central hypothesis underlying the present work is that an explicit team-oriented perspective enables effective team tracking. This hypothesis is instantiated using the model tracing technology employed in tracking individual agents. Thus, to track team activities, team models are put to service. Team models are a concrete application of the joint intentions framework and enable an agent to track team activities, regardless of the agent`s being a collaborative participant or a non-participant in the team. To facilitate real-time ambiguity resolution with team models: (i) aspects of tracking are cast as constraint satisfaction problems to exploit constraint propagation techniques; and (ii) a cost minimality criterion is applied to constrain tracking search. Empirical results from two separate tasks in real-world, dynamic environments one collaborative and one competitive - are provided.

  1. Epitaxial growth and electronic properties of well ordered phthalocyanine heterojunctions MnPc/F{sub 16}CoPc

    SciTech Connect

    Lindner, Susi; Mahns, Benjamin; Treske, Uwe; Knupfer, Martin; Vilkov, Oleg; Haidu, Francisc; Fronk, Michael; Zahn, Dietrich R. T.

    2014-09-07

    We have prepared phthalocyanine heterojunctions out of MnPc and F{sub 16}CoPc, which were studied by means of X-ray absorption spectroscopy. This heterojunction is characterized by a charge transfer at the interface, resulting in charged MnPc{sup δ} {sup +} and F{sub 16}CoPc{sup δ} {sup −} species. Our data reveal that the molecules are well ordered and oriented parallel to the substrate surface. Furthermore, we demonstrate the filling of the Co 3d{sub z{sup 2}} orbital due to the charge transfer, which supports the explanation of the density functional theory, that the charge transfer is local and affects the metal centers only.

  2. A high speed PC-based data acquisition and control system for positron imaging

    NASA Astrophysics Data System (ADS)

    Leadbeater, T. W.; Parker, D. J.

    2009-06-01

    A modular positron camera with a flexible geometry suitable for performing Positron Emission Particle Tracking (PEPT) studies on a wide range of applications has been constructed. The demand for high speed list mode data storage required for these experiments has motivated the development of an improved data acquisition system to support the existing detectors. A high speed PC-based data acquisition system is presented. This device replaces the old dedicated hardware with a compact, flexible device with the same functionality and superior performance. Data acquisition rates of up to 80 MBytes per second allow coincidence data to be saved to disk for real-time analysis or post processing. The system supports the storage of time information with resolution of a half millisecond and remote trigger data support. Control of the detector system is provided by high-level software running on the same computer.

  3. Electronic structure of Pc2Lu and (PcAlF)n oriented thin films using angle resolved photoelectron spectroscopy

    NASA Astrophysics Data System (ADS)

    Fahy, M. R.; Fujimoto, H.; Dann, A. J.; Hoshi, H.; Inokuchi, H.; Maruyama, Y.; Willis, M. R.

    1990-04-01

    Ultraviolet photoelectron spectra have been measured for the radical phthalocyanine dimer, Pc2Lu, and the fluorine bridge stacked phthalocyanine polymer (PcAlF)n. Previous workers have shown that both materials can, under appropriate conditions, be prepared in a well characterised, highly oriented thin film form. Thus, samples for this work were prepared by in situ sublimation at very slow evaporation rates onto crystalline substrates to try to maximise the degree of sample orientation. The angle dependence of the spectra were measured and the sample structure subsequently examined using high resolution TEM. The TEM results show that the (PcAlF)n films have a much higher level of orientation than the Pc2Lu films and this is reflected by the angle dependences of the UPS measurements. The spectra for (PcAlF)n are very similar to measurements on most other simple phthalocyanine compounds and have a small angular dependence. The spectra for Pc2Lu show almost no angular dependence. Again the spectra are broadly similar to that of other Pc's with two significant differences, the lowest energy peak is split and the whole spectra is shifted to lower energy. This result will be discussed in terms of simple molecular orbital ideas. The effect of air on the spectra of both materials was examined and the spectra of (PcAlF)n was found to be particularly sensitive. Attempts to determine the position of the lutetium orbitals by varying the light frequency around the lutetium resonance energies was attempted but no significant variation in the spectra was observed.

  4. PC Tutor. Bericht uber ein PC-gestutzes Tutorensystem = PC Tutor. Report on a Tutoring System with Personal Computer. ZIFF Papiere 75.

    ERIC Educational Resources Information Center

    Fritsch, Helmut

    A project was conducted to increase as well as to professionalize communication between tutors and learners in a West German university's distance education program by the use of personal computers. Two tutors worked on the systematic development of a PC-based correcting system. The goal, apart from developing general language skills in English,…

  5. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2002-01-31

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NOx emissions to 0.15 lb per million Btu or less without post-combustion flue gas cleaning. Work during previous reporting periods completed the design, installation, shakedown and initial PRB coal testing of a 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Based on these results, modifications to the gas-fired preheat combustor and PC burner were defined, along with a modified testing plan and schedule. A revised subcontract was executed with BBP to reflect changes in the pilot testing program. Modeling activities were continued to develop and verify revised design approaches for both the Preheat gas combustor and PC burner. Reactivation of the pilot test system was then begun with BBP personnel. During the previous reporting period, reactivation of the pilot test system was completed with the modified Preheat gas combustor. Following shakedown of the modified gas combustor alone, a series of successful tests of the new combustor with PRB coal using the original PC burner were completed. NOx at the furnace exit was reduced significantly with the modified gas combustor, to as low as 150 ppm with only 36 ppm CO (both corrected to 3% O2). Concurrent with testing, GTI and BBP collaborated on development of two modified designs for the PC burner optimized to fire preheated char and pyrolysis products from the Preheat gas combustor. During the current reporting period, one of the two modified PC burner designs was fabricated and installed in the pilot test facility. Testing of the modified pilot system (modified gas combustor and modified PC burner) during the quarter included 38 tests with PRB coal. NOx reduction was significantly improved to levels as low as 60-100 ppmv with CO in the range of 35-112 ppmv without any furnace air staging.

  6. Autophagy regulates colistin-induced apoptosis in PC-12 cells.

    PubMed

    Zhang, Ling; Zhao, Yonghao; Ding, Wenjian; Jiang, Guozheng; Lu, Ziyin; Li, Li; Wang, Jinli; Li, Jian; Li, Jichang

    2015-04-01

    Colistin is a cyclic cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. Our recent study demonstrated that colistin induces apoptosis in primary chick cortex neurons and PC-12 cells. Although apoptosis and autophagy have different impacts on cell fate, there is a complex interaction between them. Autophagy plays an important role as a homeostasis regulator by removing excessive or unnecessary proteins and damaged organelles. The aim of the present study was to investigate the modulation of autophagy and apoptosis regulation in PC-12 cells in response to colistin treatment. PC-12 cells were exposed to colistin (125 to 250 μg/ml), and autophagy was detected by visualization of monodansylcadaverine (MDC)-labeled vacuoles, LC3 (microtubule-associated protein 1 light chain 3) immunofluorescence microscopic examination, and Western blotting. Apoptosis was measured by flow cytometry, Hoechst 33258 staining, and Western blotting. Autophagosomes were observed after treatment with colistin for 12 h, and the levels of LC3-II gene expression were determined; observation and protein levels both indicated that colistin induced a high level of autophagy. Colistin treatment also led to apoptosis in PC-12 cells, and the level of caspase-3 expression increased over the 24-h period. Pretreatment of cells with 3-methyladenine (3-MA) increased colistin toxicity in PC-12 cells remarkably. However, rapamycin treatment significantly increased the expression levels of LC3-II and beclin 1 and decreased the rate of apoptosis of PC-12 cells. Our results demonstrate that colistin induced autophagy and apoptosis in PC-12 cells and that the latter was affected by the regulation of autophagy. It is very likely that autophagy plays a protective role in the reduction of colistin-induced cytotoxicity in neurons.

  7. Lighnting detection and tracking with consumer electronics

    NASA Astrophysics Data System (ADS)

    Kamau, Gilbert; van de Giesen, Nick

    2015-04-01

    Lightning data is not only important for environment and weather monitoring but also for safety purposes. The AS3935 Franklin Lightning Sensor (AMS, Unterpremstaetten, Austria) is a lightning sensor developed for inclusion in consumer electronics such as watches and mobile phones. The AS3935 is small (4mmx4mm) and relatively cost effective (Eu 5). The downside is that only rough distance estimates are provided, as average power is assumed for every lightning strike. To be able to track lightning, a network of devices that monitor and keep track of occurrences of lightning strikes was developed. A communication interface was established between the sensors, a data logging circuit and a microcontroller. The digital outputs of the lightning sensor and data from a GPS are processed by the microcontroller and logged onto an SD card. The interface program enables sampling parameters such as distance from the lightning strike, time of strike occurrence and geographical location of the device. For archiving and analysis purposes, the data can be transferred from the SD card to a PC and results displayed using a graphical user interface program. Data gathered shows that the device can track the frequency and movement of lightning strikes in an area. The device has many advantages as compared to other lightning sensor stations in terms of huge memory, lower power consumption, small size, greater portability and lower cost. The devices were used in a network around Nairobi, Kenya. Through multi-lateration, lightning strikes could be located with a RMSE of 2 km or better.

  8. Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2.

    PubMed

    Yang, Yifei; Ehrlich, Barbara E

    2016-08-01

    Mutations in polycystin-2 (PC2) lead to autosomal dominant polycystic kidney disease (ADPKD). The molecular mechanism linking mutations in PC2 and the pathogenesis of ADPKD is not well understood. Therefore, understanding the functional regulation of PC2 and its interaction with other proteins under both physiological and pathogenic conditions is important for elucidating the disease mechanism and identifying potential molecular targets for treatment. Normally, PC2 functions as a calcium-permeable channel whose activity is regulated by calcium binding to the C-terminal domain of PC2 (PC2 Cterm). The PC2 Cterm is also involved in the PC2 channel assembly and hetero-oligomerization with other binding partners in cells. Different functional domains of the PC2 Cterm have been studied using structural approaches. Within the PC2 Cterm, there is a calcium-binding EF-hand domain, crucial for the calcium-dependent activity of the PC2 channel. Downstream of the EF-hand domain lies a coiled-coil region, which is involved in the assembly and hetero-interaction of the PC2 protein. The PC2 Cterm can form an oligomer, mediated by the coiled-coil region. Although PC2 Cterm has been extensively studied for its relationship with ADPKD and its importance in PC2 regulation, there are misunderstandings with respect to the definition of the domain topology within the PC2 Cterm and the functional role of each domain. Here, we review previous studies that connect the molecular properties of the domains of PC2 Cterm to distinct aspects of PC2 functions and regulation. PMID:26857659

  9. Environmental Regulatory Update Table, May/June 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-07-01

    This report contains a bi-monthly update of environmental regulatory activity that is of interest to the Department of Energy. It is provided to DOE operations and contractor staff to assist and support environmental management programs by tracking regulatory developments. Any proposed regulation that raises significant issues for any DOE operation should be reported to the Office of Environmental Guidance (EH-23) as soon as possible so that the Department can make its concerns known to the appropriate regulatory agency. Items of particular interest to EH-23 are indicated by a shading of the RU{number sign}.

  10. Environmental Regulatory Update Table, May/June 1992

    SciTech Connect

    Houlberg, L.M.; Hawkins, G.T.; Lewis, E.B.; Salk, M.S.

    1992-07-01

    This report contains a bi-monthly update of environmental regulatory activity that is of interest to the Department of Energy. It is provided to DOE operations and contractor staff to assist and support environmental management programs by tracking regulatory developments. Any proposed regulation that raises significant issues for any DOE operation should be reported to the Office of Environmental Guidance (EH-23) as soon as possible so that the Department can make its concerns known to the appropriate regulatory agency. Items of particular interest to EH-23 are indicated by a shading of the RU{number_sign}.

  11. Tram-Track Suture Technique for Pupillary Capture of a Scleral Fixated Intraocular Lens

    PubMed Central

    Kim, Sung In; Kim, Kiseok

    2016-01-01

    Purpose To report a new technique using tram-track suture for pupillary capture of a scleral fixated posterior chamber intraocular lens (PC-IOL) to reposition the tilted IOL. Methods In this prospective interventional case series, we describe a tram-track suture for pupillary capture of a scleral fixated PC-IOL. A long straight needle with double-armed 10-0 polypropylene is passed behind the iris and just above the optic portion (tilted forward) of the IOL. The other straight needle with double-armed 10-0 polypropylene is passed just below the optic portion (tilted backward) of the IOL. After the IOL is repositioned properly, the polypropylene sutures are gently pulled and tied. Results Four eyes of 4 patients underwent tram-track suture for pupillary capture of a scleral fixated PC-IOL. No intra- or postoperative complications were noted, and no pupillary captures were detected during the follow-up period. Conclusions The tram-track suture technique provides good centration and stability of a PC-IOL. This technique is an easy and effective way to reposition pupillary capture of an IOL. Further, it is also minimally invasive as it maintains a closed system. PMID:27462257

  12. UWB Tracking Software Development

    NASA Technical Reports Server (NTRS)

    Gross, Julia; Arndt, Dickey; Ngo, Phong; Phan, Chau; Dusl, John; Ni, Jianjun; Rafford, Melinda

    2006-01-01

    An Ultra-Wideband (UWB) two-cluster Angle of Arrival (AOA) tracking prototype system is currently being developed and tested at NASA Johnson Space Center for space exploration applications. This talk discusses the software development efforts for this UWB two-cluster AOA tracking system. The role the software plays in this system is to take waveform data from two UWB radio receivers as an input, feed this input into an AOA tracking algorithm, and generate the target position as an output. The architecture of the software (Input/Output Interface and Algorithm Core) will be introduced in this talk. The development of this software has three phases. In Phase I, the software is mostly Matlab driven and calls C++ socket functions to provide the communication links to the radios. This is beneficial in the early stage when it is necessary to frequently test changes in the algorithm. Phase II of the development is to have the software mostly C++ driven and call a Matlab function for the AOA tracking algorithm. This is beneficial in order to send the tracking results to other systems and also to improve the tracking update rate of the system. The third phase is part of future work and is to have the software completely C++ driven with a graphics user interface. This software design enables the fine resolution tracking of the UWB two-cluster AOA tracking system.

  13. Large scale tracking algorithms.

    SciTech Connect

    Hansen, Ross L.; Love, Joshua Alan; Melgaard, David Kennett; Karelitz, David B.; Pitts, Todd Alan; Zollweg, Joshua David; Anderson, Dylan Z.; Nandy, Prabal; Whitlow, Gary L.; Bender, Daniel A.; Byrne, Raymond Harry

    2015-01-01

    Low signal-to-noise data processing algorithms for improved detection, tracking, discrimination and situational threat assessment are a key research challenge. As sensor technologies progress, the number of pixels will increase signi cantly. This will result in increased resolution, which could improve object discrimination, but unfortunately, will also result in a significant increase in the number of potential targets to track. Many tracking techniques, like multi-hypothesis trackers, suffer from a combinatorial explosion as the number of potential targets increase. As the resolution increases, the phenomenology applied towards detection algorithms also changes. For low resolution sensors, "blob" tracking is the norm. For higher resolution data, additional information may be employed in the detection and classfication steps. The most challenging scenarios are those where the targets cannot be fully resolved, yet must be tracked and distinguished for neighboring closely spaced objects. Tracking vehicles in an urban environment is an example of such a challenging scenario. This report evaluates several potential tracking algorithms for large-scale tracking in an urban environment.

  14. Explaining cloud chamber tracks

    SciTech Connect

    Broyles, A.A.

    1992-06-16

    The operation of many detection devices is usually explained in terms of the ionization tracks produced by particles despite the fact that the corresponding incident wave functions extended over the entire sensitive regions of the detectors. The mechanisms by which the wave function appears to collapse to a track is analyzed here.

  15. 2 Tracks for Faculty

    ERIC Educational Resources Information Center

    Wilson, Robin

    2012-01-01

    The academic work force has been transformed over the past several decades, less by design than out of expediency. In 1969, professors who were either tenured or tenure-track made up 78 percent of the faculty. Those working part time made up only 18.5 percent. By 2009, those proportions had almost flipped, with tenured and tenure-track making up…

  16. On the Wrong Track?

    ERIC Educational Resources Information Center

    Gursky, Daniel

    1990-01-01

    Discusses problems with student tracking. Although supporters consider tracking the best way for teachers to handle classroom diversity, many minorities say that it condemns their children to an inferior education. Studies show that heterogeneous classes benefit all students if the teachers adopt flexible instructional methods to handle the…

  17. Can Tracking Improve Learning?

    ERIC Educational Resources Information Center

    Duflo, Esther; Dupas, Pascaline; Kremer, Michael

    2009-01-01

    Tracking students into different classrooms according to their prior academic performance is controversial among both scholars and policymakers. If teachers find it easier to teach a homogeneous group of students, tracking could enhance school effectiveness and raise test scores of both low- and high-ability students. If students benefit from…

  18. Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: nanoscopic domain formation driven by cholesterol.

    PubMed Central

    Feigenson, G W; Buboltz, J T

    2001-01-01

    A ternary phase diagram is proposed for the hydrated lamellar lipid mixture dipalmitoylphosphatidylcholine/dilauroylphosphatidylcholine/cholesterol (DPPC/DLPC/cholesterol) at room temperature. The entire composition space has been thoroughly mapped by complementary experimental techniques, revealing interesting phase behavior that has not been previously described. Confocal fluorescence microscopy shows a regime of coexisting DPPC-rich ordered and DLPC-rich fluid lamellar phases, having an upper boundary at apparently constant cholesterol mole fraction chi(chol) approximately 0.16. Fluorescence resonance energy transfer experiments confirm the identification and extent of this two-phase regime and, furthermore, reveal a 1-phase regime between chi(chol) approximately 0.16 and 0.25, consisting of ordered and fluid nanoscopic domains. Dipyrene-PC excimer/monomer measurements confirm the new regime between chi(chol) approximately 0.16 and 0.25 and also show that rigidly ordered phases seem to disappear around chi(chol) approximately 0.25. This study should be considered as a step toward a more complete understanding of lateral heterogeneity within biomembranes. Cholesterol may play a role in domain separation on the nanometer scale. PMID:11371452

  19. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Nationally Tracked Source Thresholds E Appendix E to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. E Appendix E to Part 20— Nationally Tracked Source Thresholds The Terabecquerel (TBq) values are...

  20. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Nationally Tracked Source Thresholds E Appendix E to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. E Appendix E to Part 20— Nationally Tracked Source Thresholds The Terabecquerel (TBq) values are...

  1. 10 CFR Appendix E to Part 20 - Nationally Tracked Source Thresholds

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Nationally Tracked Source Thresholds E Appendix E to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. E Appendix E to Part 20— Nationally Tracked Source Thresholds The Terabecquerel (TBq) values are...

  2. TRACKED VEHICLE Rev 75

    SciTech Connect

    Raby, Eric Y.

    2007-05-08

    Revision 75 of the Tracked Vehicle software is a soft real-time simulation of a differentially steered, tracked mobile robot, which, because of the track flippers, resembles the iRobot PackBot (http://www.irobot.com/). Open source libraries are used for the physics engine (http://www.ode.org/), the display and user interface (http://www.mathies.com/cpw/), and the program command line and configuration file parameters (http://www.boost.org/). The simulation can be controlled by a USB joystick or the keyboard. The configuration file contains demonstration model parameters of no particular vehicle. This simulation can be used as a starting point for those doing tracked vehicle simulations. This simulation software is essentially a research tool which can be modified and adapted for certain types of tracked vehicle research. An open source license allows an individual researchers to tailor the code to their specific research needs.

  3. TRACKED VEHICLE Rev 75

    2007-05-08

    Revision 75 of the Tracked Vehicle software is a soft real-time simulation of a differentially steered, tracked mobile robot, which, because of the track flippers, resembles the iRobot PackBot (http://www.irobot.com/). Open source libraries are used for the physics engine (http://www.ode.org/), the display and user interface (http://www.mathies.com/cpw/), and the program command line and configuration file parameters (http://www.boost.org/). The simulation can be controlled by a USB joystick or the keyboard. The configuration file contains demonstration model parametersmore » of no particular vehicle. This simulation can be used as a starting point for those doing tracked vehicle simulations. This simulation software is essentially a research tool which can be modified and adapted for certain types of tracked vehicle research. An open source license allows an individual researchers to tailor the code to their specific research needs.« less

  4. Sparse Hashing Tracking.

    PubMed

    Zhang, Lihe; Lu, Huchuan; Du, Dandan; Liu, Luning

    2016-02-01

    In this paper, we propose a novel tracking framework based on a sparse and discriminative hashing method. Different from the previous work, we treat object tracking as an approximate nearest neighbor searching process in a binary space. Using the hash functions, the target templates and the candidates can be projected into the Hamming space, facilitating the distance calculation and tracking efficiency. First, we integrate both the inter-class and intra-class information to train multiple hash functions for better classification, while most classifiers in previous tracking methods usually neglect the inter-class correlation, which may cause the inaccuracy. Then, we introduce sparsity into the hash coefficient vectors for dynamic feature selection, which is crucial to select the discriminative and stable features to adapt to visual variations during the tracking process. Extensive experiments on various challenging sequences show that the proposed algorithm performs favorably against the state-of-the-art methods.

  5. Downsizing of an integrated tracking unit for multiple applications

    NASA Astrophysics Data System (ADS)

    Steinway, William J.; Thomas, James E.; Nicoloff, Michael J.; Patz, Mark D.

    1997-02-01

    This paper describes the specifications and capabilities of the integrated tracking unit (ITU) and its multiple applications are presented. The original ITU was developed by Coleman Research Corporation (CRC) for several federal law enforcement agencies over a four-year period and it has been used for friendly and unfriendly vehicle and person position tracking. The ITU has been down-sized to reduce its physical size, weight, and power requirements with respect to the first generation unit. The ITU consists of a global positioning system (GPS) receiver for precise position location and a cellular phone to transmit voice and data to a PC base station with a modem interface. This paper describes the down-sizing of the unit introduced in CRC's 'An Integrated Tracking Unit for Multiple Applications' paper presented at the 1995 Counterdrug Technology Assessment Center's symposium in Nashua, NH. This paper provides a description of the ITU and tested applications.

  6. Nanopore detection of double stranded DNA using a track-etched polycarbonate membrane.

    PubMed

    Kececi, Kaan; San, Nevim; Kaya, Dila

    2015-11-01

    We investigate the resistive-pulse sensing of 50-bp DNA using track-etched polycarbonate (PC) nanopores and show the translocation dynamics originating from the electrophoretic transport of DNAs. Conically shaped PC nanopore membranes have been prepared with asymmetric chemical etching technique. We show the potential and concentration dependence of DNA translocation through a PC nanopore. We find that the translocation of DNA scales linearly with both potential and concentration. Additionally, the threshold potential is determined to complete the translocation. Finally, by investigating the current-pulse amplitudes of nanopores with different tip sizes, we show that the nanopore size can be successfully used to distinguish the DNA molecules. These results suggest great promise for the sensing of short DNAs and understanding the dynamics of the translocation process using chemically-etched PC nanopores.

  7. Environmental regulatory update table

    SciTech Connect

    Brown, K.J.; Langston, M.E.; Tucker, C.S.; Reed, R.M.

    1987-06-01

    The Environmental Regulatory Update Table provides information on regulatory initiatives of interest to DOE operations and contractor staff with environmental management responsibilities. The table is updated each month with information from the Federal Register and other sources, including direct contact with regulatory agencies. Each table entry provides a chronological record of the rulemaking process for that initiative with an abstract and a projection of further action.

  8. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2002-04-29

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NOx emissions to 0.15 lb/million Btu or less without post-combustion flue gas cleaning. Work during previous reporting periods completed the design, installation, shakedown and initial PRB coal testing of a 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Based on these results, modifications to the gas-fired preheat combustor and PC burner were defined, along with a modified testing plan and schedule. During the current reporting period, BBP's subcontract was modified to reflect changes in the pilot testing program, and the modifications to the gas-fired preheat combustor were completed. The Computational Fluid Dynamics (CFD) modeling approach was defined for the combined PC burner and 3-million Btu/h pilot system. Modeling of the modified gas-fired preheat combustor was also started.

  9. Pc3 Excitation of the Ionosphere: a Preliminary Analysis

    NASA Astrophysics Data System (ADS)

    Winkler, L. I.; Howell, N.; Rajapakse, M.; Chi, P.; Moldwin, M. B.; Russell, C. T.; Skone, S.

    2006-12-01

    The fast mode (poloidal) Alfven wave should be accompanied by Pc3 events simultaneously in the ionospheric Total Electron Content (TEC) and ground magnetometer data. We examine this prediction through analyzing both field-line resonance (FLR) and non-FLR pc3 events. Ground magnetometer data collected at a 2-Hz sampling rate from the Glyndon, MN station in the McMAC chain is compared to 1- Hz data from the nearby Pinawa, Manitoba magnetometer station in the CARISMA chain using cross-phase analysis to separate FLR and non-FLR pc3 events. High-data rate GPS (0.5 Hz and 1 Hz) observations of TEC in Moorhead, MN (15 miles from the Glyndon site) are then compared to ground magnetometer data. Preliminary results from a number of events from Oct., 2005 onward show pulsations in TEC occurring in a similar timeframe to the magnetometer pulsations for both FLR and non-FLR occurrences.

  10. Review of methods to derive a Polar Cap (PC) index.

    NASA Astrophysics Data System (ADS)

    Stauning, Peter

    2016-07-01

    Since a Polar Cap (PC) index was introduced in 1985, several different methods have been used to derive index values. Basically, the northern (PCN) and southern (PCS) are based on geomagnetic recordings at Qaanaaq (Thule) and Vostok, respectively. However, different derivation methods can give index values differing by more than a factor 2. The PC indices are used, among other, in scientific analyses to link solar wind conditions to relevant geophysical effects and in forecast efforts to establish numerical criteria for imminent risk of geomagnetic storms and substorms. Thus, it is unfortunate that several different versions of the PC index have been in use, often without specifically mentioning the index version being used or without ensuring that proper documention and specification of the derivation method is available. The presentation shall briefly describe the basic calculation of a Polar Cap index and point specifically to the differences between the different derivation methods and to the consequences for the index values

  11. Relations of PC indices to further geophysical activity parameters.

    NASA Astrophysics Data System (ADS)

    Stauning, P.

    2012-04-01

    The Polar Cap (PC) indices, PCN for the index values derived from Thule magnetic data and PCS derived from Vostok data, relate to the polar cap ionospheric plasma convection driven mainly by the interaction of the solar wind with the magnetosphere. Thus, the PC indices serve to monitor the input power from the solar wind which drives a range of geophysical disturbances such as magnetic storms and substorms, energization of the plasma trapped in the Earth's near space, auroral activity, and heating of the upper atmosphere. The presentation will demonstrate the relations between the PC indices and further parameters and indices used to describe geophysical activity such as polar cap potentials, auroral electrojet activity, Joule and particle heating of the upper atmosphere, mid-latitude magnetic variations, and ring current indices Dst, SYM-H and ASY-H.

  12. Demonstration of a PC 25 Fuel Cell in Russia

    SciTech Connect

    John C. Trocciola; Thomas N. Pompa; Linda S. Boyd

    2004-09-01

    This project involved the installation of a 200kW PC25C{trademark} phosphoric-acid fuel cell power plant at Orgenergogaz, a Gazprom industrial site in Russia. In April 1997, a PC25C{trademark} was sold by ONSI Corporation to Orgenergogaz, a subsidiary of the Russian company ''Gazprom''. Due to instabilities in the Russian financial markets, at that time, the unit was never installed and started by Orgenergogaz. In October of 2001 International Fuel Cells (IFC), now known as UTC Fuel Cells (UTCFC), received a financial assistance award from the United States Department of Energy (DOE) entitled ''Demonstration of PC 25 Fuel Cell in Russia''. Three major tasks were part of this award: the inspection of the proposed site and system, start-up assistance, and installation and operation of the powerplant.

  13. PC-1D installation manual and user's guide

    SciTech Connect

    Basore, P.A.

    1991-05-01

    PC-1D is a software package for personal computers that uses finite-element analysis to solve the fully-coupled two-carrier semiconductor transport equations in one dimension. This program is particularly useful for analyzing the performance of optoelectronic devices such as solar cells, but can be applied to any bipolar device whose carrier flows are primarily one-dimensional. This User's Guide provides the information necessary to install PC-1D, define a problem for solution, solve the problem, and examine the results. Example problems are presented which illustrate these steps. The physical models and numerical methods utilized are presented in detail. This document supports version 3.1 of PC-1D, which incorporates faster numerical algorithms with better convergence properties than previous versions of the program. 51 refs., 17 figs., 5 tabs.

  14. Aspartame-induced apoptosis in PC12 cells.

    PubMed

    Horio, Yukari; Sun, Yongkun; Liu, Chuang; Saito, Takeshi; Kurasaki, Masaaki

    2014-01-01

    Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-inducing factor, and caspase family proteins were studied by Western blotting and RT-PCR. Aspartame-induced apoptosis in PC12 cells in a dose-dependent manner. In addition, aspartame exposure increased the expressions of caspases 8 and 9, and cytochrome c. These results indicate that aspartame induces apoptosis mainly via mitochondrial pathway involved in apoptosis due to oxigen toxicity.

  15. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2003-04-01

    During the current quarter, pilot scale testing was continued with the modified combustor and modified channel burner using the new PRB coal delivered in late December. Testing included benchmark testing to determine whether the system performance was comparable to that with the previous batch of PRB coal, baseline testing to characterize performance of the PC Burner without coal preheating, and parametric testing to evaluate the effect of various preheat combustor and PC burner operating variables, including reduced gas usage in the preheat combustor. A second version of the PC burner in which the secondary air channels were closed and replaced with six air nozzles was then tested with PRB coal. Plans were developed with RPI for the next phase of testing at the 100 million Btu/h scale using RPI's Coal Burner Test Facility (CBTF). A cost estimate for preparation of the CBTF and preheat burner system design, installation and testing was then prepared by RPI.

  16. Thermal Conductivity behavior of MWCNT based PMMA and PC composites

    NASA Astrophysics Data System (ADS)

    Dubey, Girija; Jindal, Prashant; Bhandari, Rajiv; Dhiman, Neha; Bajaj, Chetan; Jindal, Vijay

    Poly methyl methacrylate (PMMA) and Polycarbonate (PC) are low cost polymer materials which can be easily transformed into desired shapes for various applications. However they have poor mechanical, thermal and electrical properties which are required to be enhanced to widen their scope of applications specifically where along with high strength, rapid heat transfer is essential. Multi Walled Carbon nanotubes (MWCNTs) are excellent new materials having extraordinary mechanical and transport properties. We will report results of fabricating composites of varying compositions of MWCNTs with PMMA and PC and their thermal conductivity behaviour using simple transient heat flow methods. The samples in disk shapes of around 2 cm diameters and 0.2 cm thickness with MWCNT compositions varying up to 10 wt% were fabricated. We found that both PMMA and PC measured high thermal conductivity with increase in the composition of CNTs. The thermal conductivity of 10wt% MWCNT/PMMA composite increased by nearly two times in comparison to pure PMMA.

  17. Regulation of the differentiation of PC12 pheochromocytoma cells.

    PubMed Central

    Fujita, K; Lazarovici, P; Guroff, G

    1989-01-01

    The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolar concentrations of nerve growth factor, PC12 cells stop dividing, elaborate processes, become electrically excitable, and will make synapses with appropriate muscle cells in culture. The changes induced by nerve growth factor lead to cells that, by any number of criteria, resemble mature sympathetic neurons. These changes are accompanied by a series of biochemical alterations occurring in the membrane, the cytoplasm, and the nucleus of the cell. Some of these events are independent of changes in transcription, while others clearly involve changes in gene expression. A number of the alterations seen in the cells involve increases or decreases in the phosphorylation of key cellular proteins. The information available thus far allows the construction of a hypothesis regarding the biochemical basis of PC12 differentiation. PMID:2647474

  18. Plasma and field observations of a Pc 5 wave event

    NASA Technical Reports Server (NTRS)

    Waite, J. H.; Gallagher, D. L.; Chappell, C. R.; Chandler, M. O.; Olsen, R. C.; Comfort, R. H.; Johnson, J. F. E.; Peterson, W. K.; Weimer, D.; Shawhan, S. D.

    1986-01-01

    The particle detector and electric field data collected by the Dynamo Explorer 1 on the Pc 5 wave event encounter on July 14, 1982 are presented, yielding a nearly complete picture of the event. The overall structure of the Pc 5 seems to order the event into two distinct halves, suggesting a temporal or spatial variation of the micropulsation. Thermal plasma measurements showed that the dominant ion throughout both lobes was H(+). Significant quantities of He(+), O(+), N(+), and O(2+) were also observed to be present and rotating together in a plane normal to the magnetic field direction, due to the Pc5 E x B drift. The plasma parameters determined for the two lobes were used in theoretical calculations to predict the period of the observed resonance.

  19. Effects of vibration on differentiation of cultured PC12 cells.

    PubMed

    Ito, Yukiko; Kimura, Tsuyoshi; Nam, Kwangwoo; Katoh, Ayako; Masuzawa, Toru; Kishida, Akio

    2011-03-01

    Different types of physiological-mechanical stress, such as shear stress in vascular endothelial cells or hydrostatic pressure in chondrocytes are well known as regulators of cell function. In this study, the effects of vibration, a type of non-physiological mechanical stimulation, on differentiation of rat pheochromocytoma (PC12) cells are reported. A nano-vibration system was designed to produce nanometer-scale vibration. The frequency and amplitude of the nano-vibrations were monitored by a capacitance displacement sensor connected to an oscilloscope. When PC12 cells exposed to nerve growth factor were subjected to vibration at 10 kHz, differentiation and elongation of their neurites were promoted earlier in the culture. Vibration promoted differentiation of PC12 cells. This approach could therefore also be promising for determining of the effects of the physical environment on cell differentiation.

  20. Computer program TRACK_TEST for calculating parameters and plotting profiles for etch pits in nuclear track materials

    NASA Astrophysics Data System (ADS)

    Nikezic, D.; Yu, K. N.

    2006-01-01

    A computer program called TRACK_TEST for calculating parameters (lengths of the major and minor axes) and plotting profiles in nuclear track materials resulted from light-ion irradiation and subsequent chemical etching is described. The programming steps are outlined, including calculations of alpha-particle ranges, determination of the distance along the particle trajectory penetrated by the chemical etchant, calculations of track coordinates, determination of the lengths of the major and minor axes and determination of the contour of the track opening. Descriptions of the program are given, including the built-in V functions for the two commonly employed nuclear track materials commercially known as LR 115 (cellulose nitrate) and CR-39 (poly allyl diglycol carbonate) irradiated by alpha particles. Program summaryTitle of the program:TRACK_TEST Catalogue identifier:ADWT Program obtainable from:CPC Program Library, Queen's University of Belfast, N. Ireland Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADWT Computer:Pentium PC Operating systems:Windows 95+ Programming language:Fortran 90 Memory required to execute with typical data:256 MB No. of lines in distributed program, including test data, etc.: 2739 No. of bytes in distributed program, including test data, etc.:204 526 Distribution format:tar.gz External subprograms used:The entire code must be linked with the MSFLIB library Nature of problem: Fast heavy charged particles (like alpha particles and other light ions etc.) create latent tracks in some dielectric materials. After chemical etching in aqueous NaOH or KOH solutions, these tracks become visible under an optical microscope. The growth of a track is based on the simultaneous actions of the etchant on undamaged regions (with the bulk etch rate V) and along the particle track (with the track etch rate V). Growth of the track is described satisfactorily by these two parameters ( V and V). Several models have been presented in the past describing

  1. Welding technology transfer task/laser based weld joint tracking system for compressor girth welds

    NASA Technical Reports Server (NTRS)

    Looney, Alan

    1991-01-01

    Sensors to control and monitor welding operations are currently being developed at Marshall Space Flight Center. The laser based weld bead profiler/torch rotation sensor was modified to provide a weld joint tracking system for compressor girth welds. The tracking system features a precision laser based vision sensor, automated two-axis machine motion, and an industrial PC controller. The system benefits are elimination of weld repairs caused by joint tracking errors which reduces manufacturing costs and increases production output, simplification of tooling, and free costly manufacturing floor space.

  2. Scale adaptive compressive tracking.

    PubMed

    Zhao, Pengpeng; Cui, Shaohui; Gao, Min; Fang, Dan

    2016-01-01

    Recently, the compressive tracking (CT) method (Zhang et al. in Proceedings of European conference on computer vision, pp 864-877, 2012) has attracted much attention due to its high efficiency, but it cannot well deal with the scale changing objects due to its constant tracking box. To address this issue, in this paper we propose a scale adaptive CT approach, which adaptively adjusts the scale of tracking box with the size variation of the objects. Our method significantly improves CT in three aspects: Firstly, the scale of tracking box is adaptively adjusted according to the size of the objects. Secondly, in the CT method, all the compressive features are supposed independent and equal contribution to the classifier. Actually, different compressive features have different confidence coefficients. In our proposed method, the confidence coefficients of features are computed and used to achieve different contribution to the classifier. Finally, in the CT method, the learning parameter λ is constant, which will result in large tracking drift on the occasion of object occlusion or large scale appearance variation. In our proposed method, a variable learning parameter λ is adopted, which can be adjusted according to the object appearance variation rate. Extensive experiments on the CVPR2013 tracking benchmark demonstrate the superior performance of the proposed method compared to state-of-the-art tracking algorithms. PMID:27386298

  3. METHANE DE-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2002-01-31

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NO{sub x} emissions to 0.15 lb/million Btu or less without post-combustion flue gas cleaning. Work during the quarter included completion of the equipment fabrication and installation efforts for the 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Selection and procurement of the first two test coals and preliminary selection of the final two test coals were completed. Shakedown and commissioning activities were finished and PC Preheat pilot scale tests commenced with PRB coal.

  4. Nonbinomial distribution of relative neurite outgrowth in PC-12 cells

    SciTech Connect

    Blackman, C.F.; House, D.E.; Blanchard, J.P.

    1996-12-31

    Previously the authors reported the results of a series of experimental tests using PC-12 cells to examine the biological effects of prescribed combinations of both nerve growth factor and magnetic fields. Because the assay of the PC-12 cells is based on a binary classification of the cells following treatment, the data might be expected to have a binomial distribution. However, the data consistently show a smaller variability than that predicted by the binomial distribution model. In this paper, they examine some possible reasons for this reduction in variability in the results.

  5. [A skin cell segregating control system based on PC].

    PubMed

    Liu, Wen-zhong; Zhou, Ming; Zhang, Hong-bing

    2005-11-01

    A skin cell segregating control system based on PC (personal computer) is presented in this paper. Its front controller is a single-chip microcomputer which enables the manipulation for 6 patients simultaneously, and thus provides a great convenience for clinical treatments for vitiligo. With the use of serial port communication technology, it's possible to monitor and control the front controller in a PC terminal. And the application of computer image acquisition technology realizes the synchronous acquisition of pathologic shin cell images pre/after the operation and a case history. Clinical tests prove its conformity with national standards and the pre-set technological requirements.

  6. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Bruce Bryan; Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2005-06-30

    Large-scale combustion tests with caking bituminous coal has stopped. This stoppage has come about due to limitations in current funding available to continue large scale research and development activities at Riley's Commercial Burner Test Facility (CBTF) of the PC Preheat technology. The CBTF was secured and decommissioned in the previous quarter; work this quarter has focused on disposition of PC Preheat experimental equipment at the CBTF as well as methods for disposal of about 100 tons of residual PRB test coal in storage. GTI was granted a no-cost time extension through September 2005; a final report is due in December 2005.

  7. Effect of morphine on PC12 cells with molecular radar

    NASA Astrophysics Data System (ADS)

    Shi, Chen; Yu, Xiaoli; Lu, Jiuyi; Zhang, Chunyang; Jin, Lei; Ma, Hui; Zhang, Dacheng; Chen, Die Yan

    2000-10-01

    Molecular Radar (MR) is a new method to detect biological processes in living cells at the level of molecular, it is also the newest means to get intracellular information. In this paper we study the effect of morphine on PC12 cells using MR. The results show that the effect of morphine on PC12 cells is time- and concentration-dependent. Morphine treating for short time induces the increase and fluctuation of intracellular (CA2+), while morphine treating for long time induces chromatin condensation, loss of mitochondria membrane potential apoptosis.

  8. Run-08 pC polarization analysis - October 16, 2008

    SciTech Connect

    Dharmawardane,V.; Bazilevsky,A.; Bunce, G.; Gill, R.; Huang, H.; Makdisi, Y.; Nakagawa, I.; Morozov, B.; Okada, H.; Sivertz, M.; Zelenski, A.; Alekseev, I.; Svirida, D.

    2009-03-01

    In this note we will discuss the analysis of RHIC run 08 pC data that were collected during February 14 - March 10, 2008. An analysis method that is similar to Run 05 and Run 06 was adopted for Run 08 analysis (except few minor changes, which are described below). A detailed analysis note and a NIM article that describe the pC analysis procedure (for run 05 and run 06) can be found elsewhere. In brief, the analysis consists of calibrating the detectors, determining energy corrections ('dead layers'), determining good runs and extracting the polarization from data.

  9. A comparison of results for the Univeristy of Missouri research reactor radiological airborne release assessments obtained from PC-based computer programs

    SciTech Connect

    Rong, X.; Kutikkad, K.; Langhorst, S.M.

    1995-06-01

    The United States Environmental Protection Agency has published three computer programs, COMPLY, AIRDOS-PC, and CAP88-PC, to assist the regulated community in determining compliance with the Environmental Protection Agency radionuclide air emission standards. The programs calculate radiation doses from routine airborne release to the general public residing outside a nuclear facility site. They consider doses from inhalation, ingestion of contaminated food, air immersion, and ground deposition. A PC-based computer code, XOQDOQ-82, developed for the Nuclear Regulatory Commission, was also chosen to compare and evaluate dispersion results from the Environmental Protection Agency codes for the University of Missouri Research Reactor Center. Effects of building parameters, terrain conditions, and down-wind distances on dispersion factors were calculated. The results of this study indicated that dispersion factors calculated using AIRDOS-PC and CAP88-PC were several times lower than those calculated using XOQDOQ-82 at all distances, and those dispersion factors calculated using COMPLY were several times lower than the XOQDOQ-82 values at distances greater than 600 m. 9 refs., 4 figs., 3 tabs.

  10. Processing and intracellular localization of rice stripe virus Pc2 protein in insect cells

    SciTech Connect

    Zhao, Shuling; Zhang, Gaozhan; Dai, Xuejuan; Hou, Yanling; Li, Min; Liang, Jiansheng; Liang, Changyong

    2012-08-01

    Rice stripe virus (RSV) belongs to the genus Tenuivirus and its genome consists of four single-stranded RNAs encoding seven proteins. Here, we have analyzed the processing and membrane association of Pc2 encoded by vcRNA2 in insect cells. The enhanced green fluorescent protein (eGFP) was fused to the Pc2 and used for the detection of Pc2 fusion proteins. The results showed that Pc2 was cleaved to produce two proteins named Pc2-N and Pc2-C. When expressed alone, either Pc2-N or Pc2-C could transport to the Endoplasmic reticulum (ER) membranes independently. Further mutagenesis studies revealed that Pc2 contained three ER-targeting domains. The results led us to propose a model for the topology of the Pc2 in which an internal signal peptide immediately followed a cleavage site, and two transmembrane regions are contained.

  11. Nuclear Regulatory Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... agenda on April 26, 2010 (75 FR 21960). For this edition of the NRC's regulatory agenda, the most... publication of the last NRC semiannual agenda on April 26, 2010 (75 FR 21960). Within each group, the rules... regulations to improve the control over the distribution of source material to exempt persons and to...

  12. Utilization of arsenic trioxide as a treatment of cisplatin-resistant non-small cell lung cancer PC-9/CDDP and PC-14/CDDP cells

    PubMed Central

    SUZUKI, TOSHIHIRO; ISHIBASHI, KENICHI; YUMOTO, ATSUSHI; NISHIO, KAZUTO; OGASAWARA, YUKI

    2015-01-01

    Cisplatin is a commonly used drug in combination chemotherapy. However, various malignant tumors frequently acquire resistance to cisplatin. Arsenic trioxide (ATO) has been approved as a chemotherapeutic drug for the treatment of acute promyelocytic leukemia, and the combination of ATO and cisplatin has been revealed to demonstrate synergistic effects in ovarian and small cell lung cancer cells. Thus, it was hypothesized that ATO may also be active against cisplatin-resistant non-small cell lung cancer (NSCLC) PC-9/CDDP and PC-14/CDDP cells. The present study also evaluated the effects of ATO on the cisplatin-sensitive NSCLC PC-9 and PC-14 cell lines. Notably, ATO demonstrated a markedly decreased IC50 in the cisplatin-resistant PC-9/CDDP and PC-14/CDDP cells compared with the IC50 in the cisplatin-sensitive parental PC-9 and PC-14 cells. Additionally, it was found that arsenite accumulation in the PC-9 cell line was affected through the downregulation of GS-X pump systems. Although it is likely that cisplatin resistance in PC-9 cells does not depend on the GS-X pump systems, ATO was effective against cisplatin-resistant NSCLC PC-9/CDDP and PC-14/CDDP cells in combination chemotherapy. PMID:26622574

  13. Differential localization of prohormone convertases PC1 and PC2 in two distinct types of secretory granules in rat pituitary gonadotrophs.

    PubMed

    Uehara, M; Yaoi, Y; Suzuki, M; Takata, K; Tanaka, S

    2001-04-01

    Prohormone convertases PC1 and PC2 are endoproteases involved in prohormone cleavage at pairs of basic amino acids. There is a report that prohormone convertase exists in the rat anterior pituitary gonadotrophs, where it had previously been considered that proprotein processing does not take place. In addition to luteinizing hormone and follicle-stimulating hormone, rat pituitary gonadotrophs contain chromogranin A (CgA) and secretogranin II (SgII), two members of the family of granin proteins, which have proteolytic sites in their molecules. In the present study we examined whether there is a close correlation between subcellular localization of prohormone convertases and granin proteins. Ultrathin sections of rat anterior pituitary were immunolabeled with anti-PC1 or -PC2 antisera and then stained with immunogold. Immunogold particles for PC1 were exclusively found in large, lucent secretory granules, whereas those for PC2 were seen in both large, lucent and small, dense granules. The double-immunolabeling also demonstrated colocalization of PC2 and SgII in small, dense granules and of PC1, PC2, and CgA in large, lucent granules. These immunocytochemical results suggest that PC2 may be involved in the proteolytic processing of SgII and that both PC1 and PC2 may be necessary to process CgA. PMID:11383885

  14. Energy Tracking Software Platform

    SciTech Connect

    Ryan Davis; Nathan Bird; Rebecca Birx; Hal Knowles

    2011-04-04

    Acceleration has created an interactive energy tracking and visualization platform that supports decreasing electric, water, and gas usage. Homeowners have access to tools that allow them to gauge their use and track progress toward a smaller energy footprint. Real estate agents have access to consumption data, allowing for sharing a comparison with potential home buyers. Home builders have the opportunity to compare their neighborhood's energy efficiency with competitors. Home energy raters have a tool for gauging the progress of their clients after efficiency changes. And, social groups are able to help encourage members to reduce their energy bills and help their environment. EnergyIT.com is the business umbrella for all energy tracking solutions and is designed to provide information about our energy tracking software and promote sales. CompareAndConserve.com (Gainesville-Green.com) helps homeowners conserve energy through education and competition. ToolsForTenants.com helps renters factor energy usage into their housing decisions.

  15. Advanced Doppler tracking experiments

    NASA Technical Reports Server (NTRS)

    Armstrong, J. W.

    1989-01-01

    The Doppler tracking method is currently the only technique available for broadband gravitational wave searches in the approx. 10(exp -4) to 10(exp -1) Hz low frequency band. A brief review is given of the Doppler method, a discussion of the main noise sources, and a review of experience with current spacecraft and the prospects for sensitivity improvements in an advanced Doppler tracking experiment.

  16. Support vector tracking.

    PubMed

    Avidan, Shai

    2004-08-01

    Support Vector Tracking (SVT) integrates the Support Vector Machine (SVM) classifier into an optic-flow-based tracker. Instead of minimizing an intensity difference function between successive frames, SVT maximizes the SVM classification score. To account for large motions between successive frames, we build pyramids from the support vectors and use a coarse-to-fine approach in the classification stage. We show results of using SVT for vehicle tracking in image sequences.

  17. Installing and Managing PC Time-Control Software

    ERIC Educational Resources Information Center

    Dawson, Jennifer

    2004-01-01

    Employees of a West Virginia library system were tired of intervening in frequent patron fights over the public access PCs. In this article, the author discusses how the implementation of time-control software for an automated session reservation/management service reduced the conflict. A team was assigned to investigate PC management software.…

  18. PC-SPES: herbal formulation for prostate cancer.

    PubMed

    Marks, Leonard S; DiPaola, Robert S; Nelson, Peter; Chen, Sophie; Heber, David; Belldegrun, Arie S; Lowe, Franklin C; Fan, John; Leaders, Floyd E; Pantuck, Allan J; Tyler, Varro E

    2002-09-01

    PC-SPES is a potent eight-herb formulation sold directly to consumers; it has promising efficacy in the treatment of prostate cancer (CaP). The product induces a castrate status in most, if not all, men, resulting in a 50% or greater prostate-specific antigen reduction in the great majority of men with androgen-dependent CaP and in more than one half of the men with androgen-independent CaP. The duration of response is not yet clear. The efficacy of PC-SPES appears to exceed that of androgen ablation alone, but is not necessarily separate from an estrogenic effect. Common side effects include gynecomastia, nipple tenderness, loss of libido, and impotency; uncommon side effects include a 4% incidence of thromboembolic phenomena, but also two reports of bleeding diatheses. The mechanisms of action may involve downregulation of the androgen receptor, induction of apoptosis by way of inhibition of the bcl-2 gene, and increased expression of p53. Two marker compounds in PC-SPES are baicalin and oridonin, both of which exhibit antiproliferative effects in CaP cell lines. Thousands of men are currently obtaining this nonprescription medicine, and physicians should ask patients specifically about its use. PC-SPES is of great interest in men with androgen-independent CaP, an area in which future research should be primarily directed. PMID:12350462

  19. PC Board Layout and Electronic Drafting with CAD. Teacher Edition.

    ERIC Educational Resources Information Center

    Bryson, Jimmy

    This teacher's guide contains 11 units of instruction for a course on computer electronics and computer-assisted drafting (CAD) using a personal computer (PC). The course covers the following topics: introduction to electronic drafting with CAD; CAD system and software; basic electronic theory; component identification; basic integrated circuit…

  20. Deciding when It's Time to Buy a New PC

    ERIC Educational Resources Information Center

    Goldsborough, Reid

    2004-01-01

    How to best decide when it's time to replace your PC, whether at home or at work, is always tricky. Spending on computers can make you more productive, but it's money you otherwise cannot spend, invest or save, and faster systems always await you in the future. What is clear is that the computer industry really wants you to buy, and the computer…

  1. 39 CFR 501.16 - PC postage payment methodology.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... examination of its PC Postage system and any other applications and technology infrastructure that may have a... effectiveness of relevant provider internal controls (SOC1 Type II SSAE 16 Report). If the service organization... provider and the Postal Service with an opinion on the design and operating effectiveness of the...

  2. PC-CUBE: A Personal Computer Based Hypercube

    NASA Technical Reports Server (NTRS)

    Ho, Alex; Fox, Geoffrey; Walker, David; Snyder, Scott; Chang, Douglas; Chen, Stanley; Breaden, Matt; Cole, Terry

    1988-01-01

    PC-CUBE is an ensemble of IBM PCs or close compatibles connected in the hypercube topology with ordinary computer cables. Communication occurs at the rate of 115.2 K-band via the RS-232 serial links. Available for PC-CUBE is the Crystalline Operating System III (CrOS III), Mercury Operating System, CUBIX and PLOTIX which are parallel I/O and graphics libraries. A CrOS performance monitor was developed to facilitate the measurement of communication and computation time of a program and their effects on performance. Also available are CXLISP, a parallel version of the XLISP interpreter; GRAFIX, some graphics routines for the EGA and CGA; and a general execution profiler for determining execution time spent by program subroutines. PC-CUBE provides a programming environment similar to all hypercube systems running CrOS III, Mercury and CUBIX. In addition, every node (personal computer) has its own graphics display monitor and storage devices. These allow data to be displayed or stored at every processor, which has much instructional value and enables easier debugging of applications. Some application programs which are taken from the book Solving Problems on Concurrent Processors (Fox 88) were implemented with graphics enhancement on PC-CUBE. The applications range from solving the Mandelbrot set, Laplace equation, wave equation, long range force interaction, to WaTor, an ecological simulation.

  3. PC vs. Mac--Which Way Should You Go?

    ERIC Educational Resources Information Center

    Wodarz, Nan

    1997-01-01

    Outlines the factors in hardware, software, and administration to consider in developing specifications for choosing a computer operating system. Compares Microsoft Windows 95/NT that runs on PC/Intel-based systems and System 7.5 that runs on the Apple-based systems. Lists reasons why the Microsoft platform clearly stands above the Apple platform.…

  4. A PC-based Workstation for Robotic Discectomy

    NASA Technical Reports Server (NTRS)

    Casadei, C.; Fiorini, P.; Martelli, S.; Montanari, M.; Morri, A.

    1998-01-01

    Ths paper describes a PC-based controller for robot-assisted minimally invasive surgery. The development is motivated by the need of reducing the exposure of operating room personnel to X-rays during surgical procedures such as percutanrous discectomy.

  5. What's Under Your PC's 'Hood': A Primer for Today's Machines.

    ERIC Educational Resources Information Center

    Chen, Li; Mills, Joyce White

    2002-01-01

    Explains how to decide what type of computer to buy for a small academic library, based on software requirements, staff and patron use, and PC technology. Topics include the central processing unit; types of memory; storage devices; ports; multimedia capabilities; modems; operating systems; and monitors. (LRW)

  6. Desktop Publishing in a PC-Based Environment.

    ERIC Educational Resources Information Center

    Sims, Harold A.

    1987-01-01

    Identifies, considers, and interrelates the functionality of hardware, firmware, and software types; discusses the relationship of input and output devices in the PC-based desktop publishing environment; and reports some of what has been experienced in three years of working intensively in/with desktop publishing devices and solutions. (MES)

  7. Wf/pc Cycle 1 Calib: 4-CHIP UV Calibration

    NASA Astrophysics Data System (ADS)

    MacKenty, John

    1990-12-01

    THIS PROGRAM CALIBRATES THE QE OF THE WFC AND PC IN THE ULTRAVIOLET (F194W, F230W, AND F284W). This calibration is done for each CCD detector using exposures of a UV flux standard star. This program is intended for use only during a UV campaign.

  8. Wf/pc Cycle 2 Calib: Single Chip UV Calibration

    NASA Astrophysics Data System (ADS)

    MacKenty, John

    1991-07-01

    THIS PROGRAM CALIBRATES THE QE OF THE WFC AND PC IN THE ULTRAVIOLET (F194W, F230W, AND F284W). This calibration is done using exposures of a UV flux standard star. This program is intended for use only following a UV decontamination.

  9. The PC index: method of calculation and physical sense

    NASA Astrophysics Data System (ADS)

    Janzhura, A.; Troshichev, O.

    2012-04-01

    The PC index has been introduced [Troshichev and Andrezen, 1985; Troshichev et al., 1988] to characterize magnetic activity in the polar caps generated by the solar wind coupling with the magnetosphere. The concept of the antisunward convection within the polar cap, controlled by the interplanetary electric field EKL determined by Kan and Lee (1979), served as a basis for the method of the index calculation. Value of disturbances in the polar cap geomagnetic H and D (or X and Y) components form the basis for derivation of the PC index. The technique of PC index derivation consists of two separate procedures: (1) derivation of the statistically justified regression coefficients determining relationship between the coupling function EKL and vector of polar cap magnetic disturbance δF, and (2) calculation of PC indices by data on current δF values with use of the regression coefficients established in course of the first procedure. To exclude from examination the geomagnetic field changes unrelated to the solar wind variations the value of geomagnetic disturbance is calculated in reference to the quiet daily variation. The regression coefficients α (slope) and β (intersection) describing a linear link between values δF and EKL are calculated in combination with the optimal angle φ providing the highest correlation between δF and EKL. Parameters α, β and φ are derived based on the statistically justified sets of data. As a result the PC index corresponding to the value of coupling function EKL, irrespective of UT time, season and point of observation is determined. Validation of the PC proper derivation has been testified by the following requirements imposed on the calculated PCN and PCS indices: PCN and PCS indices should be consistent with the interplanetary electric field EKL; PCN and PCS indices should be in close agreement with each other irrespective of season and UT time; indices should not demonstrate seasonal variation; indices should not

  10. MATERIAL TRACKING USING LANMAS

    SciTech Connect

    Armstrong, F.

    2010-06-07

    LANMAS is a transaction-based nuclear material accountability software product developed to replace outdated and legacy accountability systems throughout the DOE. The core underlying purpose of LANMAS is to track nuclear materials inventory and report transactions (movement, mixing, splitting, decay, etc.) to the Nuclear Materials Management and Safeguards System (NMMSS). While LANMAS performs those functions well, there are many additional functions provided by the software product. As a material is received onto a site or created at a site, its entire lifecycle can be tracked in LANMAS complete to its termination of safeguards. There are separate functions to track material movements between and within material balance areas (MBAs). The level of detail for movements within a MBA is configurable by each site and can be as high as a site designation or as detailed as building/room/rack/row/position. Functionality exists to track the processing of materials, either as individual items or by modeling a bulk process as an individual item to track inputs and outputs from the process. In cases where sites have specialized needs, the system is designed to be flexible so that site specific functionality can be integrated into the product. This paper will demonstrate how the software can be used to input material into an account and track it to its termination of safeguards.

  11. Object Tracking Benchmark.

    PubMed

    Wu, Yi; Lim, Jongwoo; Yang, Ming-Hsuan

    2015-09-01

    Object tracking has been one of the most important and active research areas in the field of computer vision. A large number of tracking algorithms have been proposed in recent years with demonstrated success. However, the set of sequences used for evaluation is often not sufficient or is sometimes biased for certain types of algorithms. Many datasets do not have common ground-truth object positions or extents, and this makes comparisons among the reported quantitative results difficult. In addition, the initial conditions or parameters of the evaluated tracking algorithms are not the same, and thus, the quantitative results reported in literature are incomparable or sometimes contradictory. To address these issues, we carry out an extensive evaluation of the state-of-the-art online object-tracking algorithms with various evaluation criteria to understand how these methods perform within the same framework. In this work, we first construct a large dataset with ground-truth object positions and extents for tracking and introduce the sequence attributes for the performance analysis. Second, we integrate most of the publicly available trackers into one code library with uniform input and output formats to facilitate large-scale performance evaluation. Third, we extensively evaluate the performance of 31 algorithms on 100 sequences with different initialization settings. By analyzing the quantitative results, we identify effective approaches for robust tracking and provide potential future research directions in this field.

  12. The impact of Polycomb group (PcG) and Trithorax group (TrxG) epigenetic factors in plant plasticity.

    PubMed

    de la Paz Sanchez, Maria; Aceves-García, Pamela; Petrone, Emilio; Steckenborn, Stefan; Vega-León, Rosario; Álvarez-Buylla, Elena R; Garay-Arroyo, Adriana; García-Ponce, Berenice

    2015-11-01

    Current advances indicate that epigenetic mechanisms play important roles in the regulatory networks involved in plant developmental responses to environmental conditions. Hence, understanding the role of such components becomes crucial to understanding the mechanisms underlying the plasticity and variability of plant traits, and thus the ecology and evolution of plant development. We now know that important components of phenotypic variation may result from heritable and reversible epigenetic mechanisms without genetic alterations. The epigenetic factors Polycomb group (PcG) and Trithorax group (TrxG) are involved in developmental processes that respond to environmental signals, playing important roles in plant plasticity. In this review, we discuss current knowledge of TrxG and PcG functions in different developmental processes in response to internal and environmental cues and we also integrate the emerging evidence concerning their function in plant plasticity. Many such plastic responses rely on meristematic cell behavior, including stem cell niche maintenance, cellular reprogramming, flowering and dormancy as well as stress memory. This information will help to determine how to integrate the role of epigenetic regulation into models of gene regulatory networks, which have mostly included transcriptional interactions underlying various aspects of plant development and its plastic response to environmental conditions.

  13. Effect of nanoscale SubPc interfacial layer on the performance of inverted polymer solar cells based on P3HT/PC71BM.

    PubMed

    Kim, Jung Yong; Noh, Seunguk; Nam, Young Min; Kim, Jun Young; Roh, Jeongkyun; Park, Myeongjin; Amsden, Jason J; Yoon, Do Y; Lee, Changhee; Jo, Won Ho

    2011-11-01

    The effect of a nanoscale boron subphthalocyanine chloride (SubPc) interfacial layer on the performance of inverted polymer solar cells based on poly (3-hexyl thiophene) (P3HT) and [6,6]-phenyl-C(71)-butyric acid methyl ester (PC(71)BM) was studied. When a 1 nm SubPc layer was introduced between the active layer (P3HT:PC(71)BM) and MoO(x) in the device with ITO/ZnO/P3HT:PC(71)BM/SubPc/MoO(x)/Al configuration, the power conversion efficiency (PCE) was increased from 3.42 (without SubPc) to 3.59%. This improvement is mainly attributed to the enhanced open-circuit voltage from 0.62 to 0.64 V. When the Flory-Huggins interaction parameters were estimated from the solubility parameters through the contact angle measurement, it revealed that the interaction between SubPc and PC(71)BM is more attractive than that between SubPc and P3HT at the interface of P3HT:PC(71)BM/SubPc, through which charges are well transported from the active layer to the anode. This is supported by a decrease of the contact resistance from 5.49 (SubPc 0 nm) to 0.94 MΩ cm (SubPc 1 nm). The photoelectron spectra provide another evidence for the enhanced PCE, exhibiting that the 1 nm thick SubPc layer extracts more photoelectrons from the active layer than other thicknesses. PMID:21970412

  14. Molecular cloning and expression of prohormone convertases PC1 and PC2 in the pituitary gland of the bullfrog, Rana catesbeiana.

    PubMed

    Yaoi, Yuichi; Suzuki, Masakazu; Tomura, Hideaki; Kikuyama, Sakae; Tanaka, Shigeyasu

    2003-09-01

    We cloned cDNAs encoding PC1 and PC2 from a cDNA library constructed for the anterior pituitary gland of the bullfrog (Rana catesbeiana) and sequenced them. The bullfrog PC1 cDNA consisted of 2972 base pairs (bp) with an open reading frame of 2208 bp and encoded a protein of 736 amino acids, including a putative signal peptide of 26 amino acids. The protein showed a high homology to R. ridibunda PC1 (95.1%) and mammalian PC1 (72.6%). The bullfrog PC2 cDNA consisted of 2242 bp with an open reading frame of 1914 bp and encoded a protein of 638 amino acids, including a putative signal peptide of 23 amino acids. This protein showed a high homology to R. ridibunda PC2 (95.5%) and mammalian PC2 (84.8%). The catalytic triad of serine proteinases of the subtilisin family was found at Asp-168, His-209, and Ser-383 in the PC1 protein and at Asp-167, His-208, and Ser-384 in the PC2 protein. In situ hybridization staining revealed that PC2 mRNA was detected in corticotrope cells of the tadpoles, but not in those of the adults. In the adult, only PC1 mRNA was detected in the pars distalis but both PC1 and PC2 mRNAs were detected in the pars intermedia. The data also showed that PC1 mRNA was expressed in gonadotrope cells. PMID:14578575

  15. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2002-10-29

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NO{sub x} emissions to 0.15 lb per million Btu or less without post-combustion flue gas cleaning. Work during previous reporting periods completed the design, installation, shakedown and initial PRB coal testing of a 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Based on these results, modifications to the gas-fired preheat combustor and PC burner were defined, along with a modified testing plan and schedule. A revised subcontract was executed with BBP to reflect changes in the pilot testing program. Modeling activities were continued to develop and verify revised design approaches for both the Preheat gas combustor and PC burner. Reactivation of the pilot test system was then begun with BBP personnel. During the current reporting period, reactivation of the pilot test system was completed with the modified Preheat gas combustor. Following shakedown of the modified gas combustor alone, a series of successful tests of the new combustor with PRB coal using the original PC burner were completed. NO{sub x} at the furnace exit was reduced significantly with the modified gas combustor, to as low as 150 ppm with only 36 ppm CO (both corrected to 3% O{sub 2}). Concurrent with testing, GTI and BBP collaborated on development of two modified designs for the PC burner optimized to fire preheated char and pyrolysis products from the Preheat gas combustor.

  16. IPEG- IMPROVED PRICE ESTIMATION GUIDELINES (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Aster, R. W.

    1994-01-01

    The Improved Price Estimation Guidelines, IPEG, program provides a simple yet accurate estimate of the price of a manufactured product. IPEG facilitates sensitivity studies of price estimates at considerably less expense than would be incurred by using the Standard Assembly-line Manufacturing Industry Simulation, SAMIS, program (COSMIC program NPO-16032). A difference of less than one percent between the IPEG and SAMIS price estimates has been observed with realistic test cases. However, the IPEG simplification of SAMIS allows the analyst with limited time and computing resources to perform a greater number of sensitivity studies than with SAMIS. Although IPEG was developed for the photovoltaics industry, it is readily adaptable to any standard assembly line type of manufacturing industry. IPEG estimates the annual production price per unit. The input data includes cost of equipment, space, labor, materials, supplies, and utilities. Production on an industry wide basis or a process wide basis can be simulated. Once the IPEG input file is prepared, the original price is estimated and sensitivity studies may be performed. The IPEG user selects a sensitivity variable and a set of values. IPEG will compute a price estimate and a variety of other cost parameters for every specified value of the sensitivity variable. IPEG is designed as an interactive system and prompts the user for all required information and offers a variety of output options. The IPEG/PC program is written in TURBO PASCAL for interactive execution on an IBM PC computer under DOS 2.0 or above with at least 64K of memory. The IBM PC color display and color graphics adapter are needed to use the plotting capabilities in IPEG/PC. IPEG/PC was developed in 1984. The original IPEG program is written in SIMSCRIPT II.5 for interactive execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 300K of 8 bit bytes. The original IPEG was developed in 1980.

  17. Induction of cytoprotective autophagy in PC-12 cells by cadmium

    SciTech Connect

    Wang, Qiwen; Zhu, Jiaqiao; Zhang, Kangbao; Jiang, Chenyang; Wang, Yi; Yuan, Yan; Bian, Jianchun; Liu, Xuezhong; Gu, Jianhong; Liu, Zongping

    2013-08-16

    Highlights: •Cadmium can promote early upregulation of autophagy in PC-12 cells. •Autophagy precedes apoptosis in cadmium-treated PC-12 cells. •Cadmium-induced autophagy is cytoprotective in PC-12 cells. •Class III PI3K/beclin-1/Bcl-2 signaling pathway plays a positive role in cadmium-triggered autophagy. -- Abstract: Laboratory data have demonstrated that cadmium (Cd) may induce neuronal apoptosis. However, little is known about the role of autophagy in neurons. In this study, cell viability decreased in a dose- and time-dependent manner after treatment with Cd in PC-12 cells. As cells were exposed to Cd, the levels of LC3-II proteins became elevated, specific punctate distribution of endogenous LC3-II increased, and numerous autophagosomes appeared, which suggest that Cd induced a high level of autophagy. In the late stages of autophagy, an increase in the apoptosis ratio was observed. Likewise, pre-treatment with chloroquine (an autophagic inhibitor) and rapamycin (an autophagic inducer) resulted in an increased and decreased percentage of apoptosis in contrast to other Cd-treated groups, respectively. The results indicate that autophagy delayed apoptosis in Cd-treated PC-12 cells. Furthermore, co-treatment of cells with chloroquine reduced autophagy and cell activity. However, rapamycin had an opposite effect on autophagy and cell activity. Moreover, class III PI3 K/beclin-1/Bcl-2 signaling pathways served a function in Cd-induced autophagy. The findings suggest that Cd can induce cytoprotective autophagy by activating class III PI3 K/beclin-1/Bcl-2 signaling pathways. In sum, this study strongly suggests that autophagy may serve a positive function in the reduction of Cd-induced cytotoxicity.

  18. NASA's Agency-Wide Strategy for Environmental Regulatory Risk Analysis and Communication

    NASA Technical Reports Server (NTRS)

    Scroggins, Sharon

    2008-01-01

    NASA's Agency-wide.resource for identifying and managing risks associated with changing environmental regulations Goals of the RRAC PC: 1) Proactively. detect, analyze and communicate environmental regulatory risks to NASA Programs and facilities; 2) Communicate with regulators and participate in the mitigation of such risks; and 3) Provide centralized support on emerging regulations to NASA HQ Environmental Management Division. When significant regulatory changes are identified, timely communication is essential. Communication of changing requirements to the regulatory stakeholders - NASA Programs and Facilities. Communication of potential issues to management and, when appropriate, back to the regulating agency.

  19. Regulatory guidance document

    SciTech Connect

    1994-05-01

    The Office of Civilian Radioactive Waste Management (OCRWM) Program Management System Manual requires preparation of the OCRWM Regulatory Guidance Document (RGD) that addresses licensing, environmental compliance, and safety and health compliance. The document provides: regulatory compliance policy; guidance to OCRWM organizational elements to ensure a consistent approach when complying with regulatory requirements; strategies to achieve policy objectives; organizational responsibilities for regulatory compliance; guidance with regard to Program compliance oversight; and guidance on the contents of a project-level Regulatory Compliance Plan. The scope of the RGD includes site suitability evaluation, licensing, environmental compliance, and safety and health compliance, in accordance with the direction provided by Section 4.6.3 of the PMS Manual. Site suitability evaluation and regulatory compliance during site characterization are significant activities, particularly with regard to the YW MSA. OCRWM`s evaluation of whether the Yucca Mountain site is suitable for repository development must precede its submittal of a license application to the Nuclear Regulatory Commission (NRC). Accordingly, site suitability evaluation is discussed in Chapter 4, and the general statements of policy regarding site suitability evaluation are discussed in Section 2.1. Although much of the data and analyses may initially be similar, the licensing process is discussed separately in Chapter 5. Environmental compliance is discussed in Chapter 6. Safety and Health compliance is discussed in Chapter 7.

  20. Face and facial parts tracking for acquiring nonverbal information

    NASA Astrophysics Data System (ADS)

    Funahashi, Takuma; Fujiwara, Takayuki; Koshimizu, Hiroyasu

    2005-12-01

    Since, at our laboratory, the basic configuration of the facial caricaturing system PICASSO has been constructed, it is strongly expected to get sufficient input image from a person who is naturally performing in front of the PICASSO camera system. From this viewpoint, we developed a face tracking PC system for capturing sufficient facial image especially in size by means of PTZ (Pan-Tilt-Zoom) camera collaborated with a fixed CCD camera. Irises are successfully recognized from the motion images captured from PTZ camera. These irises can be utilized to provide a key feature for realizing an automated facial recognizing system. In this system, a person performing naturally in pose and in facial expression within the scope of the fixed CCD camera can be stably tracked and the sufficient images in resolution of PTZ camera were successfully analyzed for iris recognition and facial parts extractions. This face tracking and face recognition system was characterized by a novel template replacement scheme among the successive image frames. Experimental results were also demonstrated in this paper. This system works well in a practical speed 6-9fps on a usual PC connected to these cameras.

  1. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human

    SciTech Connect

    Mbikay, M.; Seidah, N.G.; Chretien, M.

    1995-03-01

    The genes for three subtilisin/kexin-like proprotein convertases, PC4, PC5, and PACE4, were mapped in the mouse by RFLP analysis of a DNA panel from a (C57BL/6JEi x SPRET/Ei) F{sub 1} x SPRET/Ei backcross. The chromosomal locations of the human homologs were determined by Southern blot analysis of a DNA panel from human-rodent somatic cell hybrids, most of which contained a single human chromosome each. The gene for PC4 (Pcsk4 locus) mapped to mouse chromosome 10, close to the Adn (adipsin, a serine protease) locus and near the Amh (anti-Mullerian hormone) locus; in a human, the gene was localized to chromosome 19. The gene for PC5 (Pcsk5 locus) mapped to mouse chromosome 19 close to the Lpc1 (lipoacortin-1) locus and, in human, was localized to chromosome 9. The gene for PACE4 (Pcsk6 locus) mapped to mouse chromosome 7, at a distance of 13 cM from the Pcsk3 locus, which specifies furin, another member of this family of enzymes previoulsy mapped to this chromosome. This is in concordance with the known close proximity of these two loci in the homologous region on human chromosome 15q25-qter. Pcsk3 and Pcsk6 mapped to a region of mouse chromosome 7 that has been associated cytogenetically with postnatal lethality in maternal disomy, suggesting that these genes might be candidates for imprinting. 43 refs., 3 figs., 2 tabs.

  2. RT-PCR analysis of the expression of POMC and its processing enzyme PC1 in amphibian melanotropes.

    PubMed

    Peinado, J R; Cruz-García, D; Vázquez-Martínez, R; Anouar, Y; Tonon, M C; Vaudry, H; Gracia-Navarro, F; Castaño, J P; Malagón, M M

    2006-06-01

    The frog intermediate lobe comprises two functionally distinct cell subtypes, referred to as secretory and storage melanotropes, which differ in their ultrastructure, secretory, and synthetic rates, and display dissimilar responses to hypothalamic regulatory factors. All these differences make melanotrope subtypes an excellent model to analyze the expression and regulation of genes involved in the control and maintenance of the secretory state of endocrine cells. However, quantification of the expression levels of genes involved in the secretory process requires the characterization of a gene whose expression remains constant irrespective of the secretory state of the cells. In this study, we have cloned the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene from frog pituitary and have evaluated its suitability as internal standard in gene expression studies in melanotropes. A semiquantitative RT-PCR system developed to this end revealed that secretory melanotropes and storage melanotropes possess similar expression levels of GAPDH, whereas, as expected, secretory melanotropes showed higher levels of POMC transcripts than storage cells. Furthermore, we found that the expression of the convertase PC1, an intracellular protease involved in POMC processing, parallels that of POMC, thus suggesting that the higher secretory rate of the POMC-derived peptide alpha-MSH exhibited by secretory melanotropes is supported by their higher PC1 expression levels. In addition, we have shown that both POMC and PC1 mRNAs are up-regulated by the hypothalamic factor TRH in melanotrope cell cultures. In contrast, the inhibitory factor NPY reduced the expression level of the convertase but did not modify that of POMC. Taken together, these results demonstrate that PC1 expression is regulated in melanotropes by both stimulatory (TRH) and inhibitory (NPY) hypothalamic signals, in a manner which essentially parallels that observed for the precursor POMC.

  3. Regulatory sequence analysis tools.

    PubMed

    van Helden, Jacques

    2003-07-01

    The web resource Regulatory Sequence Analysis Tools (RSAT) (http://rsat.ulb.ac.be/rsat) offers a collection of software tools dedicated to the prediction of regulatory sites in non-coding DNA sequences. These tools include sequence retrieval, pattern discovery, pattern matching, genome-scale pattern matching, feature-map drawing, random sequence generation and other utilities. Alternative formats are supported for the representation of regulatory motifs (strings or position-specific scoring matrices) and several algorithms are proposed for pattern discovery. RSAT currently holds >100 fully sequenced genomes and these data are regularly updated from GenBank.

  4. OCULUS Sea Track Fusion Service

    NASA Astrophysics Data System (ADS)

    Panagiotou, Stylianos C.; Rizogiannis, Constantinos; Katsoulis, Stavros; Lampropoulos, Vassilis; Kanellopoulos, Sotirios; Thomopoulos, Stelios C. A.

    2015-06-01

    Oculus Sea is a complete solution regarding maritime surveillance and communications at Local as well as Central Command and Control level. It includes a robust and independent track fusion service whose main functions include: 1) Interaction with the User to suggest the fusion of two or more tracks, confirm Track ID and Vessel Metadata creation for the fused track, and suggest de-association of two tracks 2) Fusion of same vessel tracks arriving simultaneously from multiple radar sensors featuring track Association, track Fusion of associated tracks to produce a more accurate track, and Multiple tracking filters and fusion algorithms 3) Unique Track ID Generator for each fused track 4) Track Dissemination Service. Oculus Sea Track Fusion Service adopts a system architecture where each sensor is associated with a Kalman estimator/tracker that obtains an estimate of the state vector and its respective error covariance matrix. Finally, at the fusion center, association and track state estimation fusion are carried out. The expected benefits of this system include multi-sensor information fusion, enhanced spatial resolution, and improved target detection.

  5. CARES/PC - CERAMICS ANALYSIS AND RELIABILITY EVALUATION OF STRUCTURES

    NASA Technical Reports Server (NTRS)

    Szatmary, S. A.

    1994-01-01

    The beneficial properties of structural ceramics include their high-temperature strength, light weight, hardness, and corrosion and oxidation resistance. For advanced heat engines, ceramics have demonstrated functional abilities at temperatures well beyond the operational limits of metals. This is offset by the fact that ceramic materials tend to be brittle. When a load is applied, their lack of significant plastic deformation causes the material to crack at microscopic flaws, destroying the component. CARES/PC performs statistical analysis of data obtained from the fracture of simple, uniaxial tensile or flexural specimens and estimates the Weibull and Batdorf material parameters from this data. CARES/PC is a subset of the program CARES (COSMIC program number LEW-15168) which calculates the fast-fracture reliability or failure probability of ceramic components utilizing the Batdorf and Weibull models to describe the effects of multi-axial stress states on material strength. CARES additionally requires that the ceramic structure be modeled by a finite element program such as MSC/NASTRAN or ANSYS. The more limited CARES/PC does not perform fast-fracture reliability estimation of components. CARES/PC estimates ceramic material properties from uniaxial tensile or from three- and four-point bend bar data. In general, the parameters are obtained from the fracture stresses of many specimens (30 or more are recommended) whose geometry and loading configurations are held constant. Parameter estimation can be performed for single or multiple failure modes by using the least-squares analysis or the maximum likelihood method. Kolmogorov-Smirnov and Anderson-Darling goodness-of-fit tests measure the accuracy of the hypothesis that the fracture data comes from a population with a distribution specified by the estimated Weibull parameters. Ninety-percent confidence intervals on the Weibull parameters and the unbiased value of the shape parameter for complete samples are provided

  6. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Bruce Bryan; Serguei Nester; Joseph Rabovitser; Stan Wohadlo

    2005-09-30

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to ready technology for full-scale commercial deployment to meet the market demand for NO{sub x} reduction technologies. Over half of the electric power generated in the U.S. is produced by coal combustion, and more than 80% of these units utilize PC combustion technology. Conventional measures for NOx reduction in PC combustion processes rely on combustion and post-combustion modifications. A variety of combustion-based NO{sub x} reduction technologies are in use today, including low-NO{sub x} burners (LNBs), flue gas recirculation (FGR), air staging, and natural gas or other fuel reburning. Selective non-catalytic reduction (SNCR) and selective catalytic reduction (SCR) are post-combustion techniques. NO{sub x} reduction effectiveness from these technologies ranges from 30 to 60% and up to 90-93% for SCR. Typically, older wall-fired PC burner units produce NO{sub x} emissions in the range of 0.8-1.6 lb/million Btu. Low-NO{sub x} burner systems, using combinations of fuel staging within the burner and air staging by introduction of overfire air in the boiler, can reduce NO{sub x} emissions by 50-60%. This approach alone is not sufficient to meet the desired 0.15 lb/million Btu NO{sub x} standard with a range of coals and boiler loads. Furthermore, the heavy reliance on overfire air can lead to increased slagging and corrosion in furnaces, particularly with higher-sulfur coals, when LNBs are operated at sub-stoichiometric conditions to reduce fuel-derived NOx in the flame. Therefore, it is desirable

  7. 3 CFR - Regulatory Review

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... been learned since that time. Far more is now known about regulation—not only about when it is... interests of future generations; identify methods of ensuring that regulatory review does not produce...

  8. Magnetic Low-Friction Track

    NASA Astrophysics Data System (ADS)

    Paetkau, Mark; Bahniwal, Manpreet; Gamblen, James

    2008-05-01

    The standard low-friction tracks used to test Newton's laws are the air track and the low-friction cart track. Both are commercially available and provide low-friction environments to test various physics concepts. At a recent science fair, one of the authors (JG) presented a magnetically levitated cart and track. A literature search found no previous testing of magnetically levitated carts. This paper compares a magnetically levitated cart against the two standard low-friction tracks.

  9. Assessing the regulatory picture

    SciTech Connect

    Not Available

    1994-02-01

    This article addresses the safety of the nation's drinking water supply and discusses compliance of the Clean Water Act. Right now, the shape of the regulatory future is uncertain. The results of the D-DBP regulatory negotiation are imminent. Congress is ready to begin debating reauthorization of the Safe Drinking Water Act, and utilities are trying to comply with the regulations while trying not to price water out of the reach of some of their customers.

  10. NRC regulatory initiatives

    SciTech Connect

    Johnson, T.C.

    1989-11-01

    The US Nuclear Regulatory Commission (NRC) is addressing several low-level waste disposal issues that will be important to waste generators and to States and Compacts developing new disposal capacity. These issues include Greater-Than-Class C (GTCC) waste, mixed waste, below regulatory concern (BRC) waste, and the low-level waste data base. This paper discusses these issues and their current status.

  11. Track recording plastic compositions

    NASA Technical Reports Server (NTRS)

    Tarle, Gregory (Inventor)

    1983-01-01

    Improved nuclear track recording plastic compositions are provided which exhibit greatly decreased surface roughness when etched to produce visible tracks of energetic nuclear particles which have passed into and/or through said plastic. The improved compositions incorporate a small quantity of a phthalic acid ester into the major plastic component which is derived from the polymerization of monomeric di-ethylene glycol bis allyl carbonate. Di-substituted phthalic acid esters are preferred as the added component, with the further perference that the ester substituent has a chain length of 2 or more carbon atoms. The inclusion of the phthalic acid ester to an extent of from about 1-2% by weight of the plastic compositions is sufficient to drastically reduce the surface roughness ordinarily produced when the track recording plastic is contacted by etchants.

  12. Controlled Document Tracking Software

    1992-08-24

    MANTRACK is an automated, controlled document tracking system which does the following and reduces staff time required to perform these tasks: generates transmittal letters/receipts for every controlled copy issued (merged from a current distribution list), tracks the return of transmittal receipts, facilitates the check-in of the large number of transmittal receipts returned (using a barcode reader), generates a reminder list which prompts the cyclic review and evaluation of existing documents, generates overdue reminders for themore » return of past-due transmittal receipts, tracks the number of Procedure Change Directives (PCD) currently in effect for each procedure, generates and maintains current distribution lists for each document, generates a current table of contents when updates to the document (usually a procedure manual) are made.« less

  13. Tracks to therapy

    NASA Technical Reports Server (NTRS)

    Katz, R.; Cucinotta, F. A.

    1999-01-01

    Studies of the structure of particle tracks have led to models of track effects based on radial dose and radiobiological target theory that have been very successful in describing and predicting track effects in physical, chemical, and biological systems. For describing mammalian cellular inactivation two inactivation modes are required, called gamma-kill and ion-kill, the first due to synergistic effects of delta rays from adjacent ion paths thus resembling the effects from gamma rays, and the second to the effects of single ion transits through a cell nucleus. The ion-kill effect is more severe, where the fraction of cells experiencing ion kill is responsible for a decrease in the oxygen enhancement ratio, and an increase in relative biological effectiveness, but these are accompanied by loss of repair, hence to a reduction in the efficiency of fractionation in high LET therapy, as shown by our calculations for radiobiological effects in the "spread out Bragg Peak".

  14. Controlled Document Tracking Software

    SciTech Connect

    Haas, Roswitha T.

    1992-08-24

    MANTRACK is an automated, controlled document tracking system which does the following and reduces staff time required to perform these tasks: generates transmittal letters/receipts for every controlled copy issued (merged from a current distribution list), tracks the return of transmittal receipts, facilitates the check-in of the large number of transmittal receipts returned (using a barcode reader), generates a reminder list which prompts the cyclic review and evaluation of existing documents, generates overdue reminders for the return of past-due transmittal receipts, tracks the number of Procedure Change Directives (PCD) currently in effect for each procedure, generates and maintains current distribution lists for each document, generates a current table of contents when updates to the document (usually a procedure manual) are made.

  15. Tracking Immune Cell Proliferation and Cytotoxic Potential Using Flow Cytometry

    PubMed Central

    Tario, Joseph D.; Muirhead, Katharine A.; Pan, Dalin; Munson, Mark E.; Wallace, Paul K.

    2015-01-01

    In the second edition of this series, we described the use of cell tracking dyes in combination with tetramer reagents and traditional phenotyping protocols to monitor levels of proliferation and cytokine production in antigen-specific CD8+ T cells. In particular, we illustrated how tracking dye fluorescence profiles could be used to ascertain the precursor frequencies of different subsets in the T-cell pool that are able to bind tetramer, synthesize cytokines, undergo antigen-driven proliferation, and/or carry out various combinations of these functional responses. Analysis of antigen-specific proliferative responses represents just one of many functions that can be monitored using cell tracking dyes and flow cytometry. In this third edition, we address issues to be considered when combining two different tracking dyes with other phenotypic and viability probes for the assessment of cytotoxic effector activity and regulatory T-cell functions. We summarize key characteristics of and differences between general protein- and membrane-labeling dyes, discuss determination of optimal staining concentrations, and provide detailed labeling protocols for both dye types. Examples of the advantages of two-color cell tracking are provided in the form of protocols for (a) independent enumeration of viable effector and target cells in a direct cytotoxicity assay and (b) simultaneous monitoring of proliferative responses in effector and regulatory T cells. PMID:21116982

  16. Magnetospheric filter effect for Pc 3 Alfven mode waves

    NASA Technical Reports Server (NTRS)

    Zhang, X.; Comfort, R. H.; Gallagher, D. L.; Green, J. L.; Musielak, Z. E.; Moore, T. E.

    1994-01-01

    We present a ray-tracing study of the propagation of Pc 3 Alfven mode waves originating at the dayside magnetopause. This study reveals interesting features of a magnetospheric filter effect for these waves. Pc 3 Alfven mode waves cannot penetrate to low Earth altitudes unless the wave frequency is below approximately 30 mHz. Configurations of the dispersion curves and the refractive index show that the gyroresonance and pseudo-cutoff introduced by the heavy ion O(+) block the waves. When the O(+) concentration is removed from the plasma composition, the barriers caused by the O(+) no longer exist, and waves with much higher frequencies than 30 mHz can penetrate to low altitudes. The result that the 30 mHz or lower frequency Alfven waves can be guided to low altitudes agrees with ground-based power spectrum observations at high latitudes.

  17. Magnetospheric filter effect for Pc 3 Alfven mode waves

    NASA Technical Reports Server (NTRS)

    Zhang, X.; Comfort, R. H.; Gallagher, D. L.; Green, J. L.; Musielak, Z. E.; Moore, T. E.

    1995-01-01

    We present a ray-tracing study of the propagation of Pc 3 Alfven mode waves originating at the dayside magnetopause. This study reveals interesting features of magnetospheric filter effect for these waves. Pc 3 Alfven mode waves cannot penetrate to low Earth altitudes unless the wave frequency is below approximately 30 mHz. Configurations of the dispersion curves and the refractive index show that the gyroresonance and pseudo-cutoff introduced by the heavy ion O(+) block the waves. When the O(+) concentration is removed from the plasma composition, the barriers caused by the O(+) no longer exist, and waves with much higher frequencies than 30 mHz can penetrate to low altitudes. The result that the 30 mHz or lower frequency Alfven waves can be guided to low altitudes agrees with ground-based power spectrum observation at high altitudes.

  18. Conversion from 8800 to 8800PC -- Evaluation and experience

    SciTech Connect

    Miner, A.E.; Lawson, B.J.

    1998-03-20

    Though a final version of the software is pending the 8800PC operating system host computer is a welcomed change from the old Digital (DEC) host computer. The 8800PC host computer uses the Windows NT operating system and has proven to be very user friendly. Descriptive window messages replace the cryptic coding of the DEC host. Though numerous electrical components were replaced, system calibration remained constant. Calibrated Thermoluminescent (TL) output from a randomly selected 8815 field card was measured before and after the upgrade. The % difference, when comparing calibrated output from an upgraded reader to the non upgraded reader, ranged from 0.2 to 3%. The most disappointing aspect of the upgrade experience was the lag time between hardware installation and software completion.

  19. Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

    PubMed

    Blum, D; Torch, S; Nissou, M F; Benabid, A L; Verna, J M

    2000-04-14

    6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic effects of 6-OHDA. These two latter compounds considerably slow down 6-OHDA oxidation in a cell free system suggesting a direct chemical interaction with the neurotoxin. Moreover, desipramine does not protect PC12 cells and 6-OHDA is also strongly toxic towards non-catecholaminergic C6 and NIH3T3 cells. These results thus suggest that 6-OHDA toxicity on PC12 cells mainly involves an extracellular process. PMID:10754220

  20. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2005-09-30

    Large-scale combustion tests with caking bituminous coal has stopped. This stoppage has come about due to limitations in current funding available to continue large scale research and development activities at Riley Power's Commercial Burner Test Facility (CBTF) of the PC Preheat technology. The CBTF was secured and decommissioned in the previous quarter; work this quarter work completed the securing the proper disposition of all PC Preheat experimental equipment at the PSCF and CBTF and completing negotiations with AES Westover (a power plant in Johnson City, New York) to accept 130 tons of residual PRB test coal in storage. The coal transport to Westover occurred at the end of August. GTI was granted a no-cost time extension through September 2005; immediate efforts are focused on completing a draft final report, which is due in October 31, 2005 and the final report in December.

  1. Flexible missile autopilot design studies with PC-MATLAB/386

    NASA Technical Reports Server (NTRS)

    Ruth, Michael J.

    1989-01-01

    Development of a responsive, high-bandwidth missile autopilot for airframes which have structural modes of unusually low frequency presents a challenging design task. Such systems are viable candidates for modern, state-space control design methods. The PC-MATLAB interactive software package provides an environment well-suited to the development of candidate linear control laws for flexible missile autopilots. The strengths of MATLAB include: (1) exceptionally high speed (MATLAB's version for 80386-based PC's offers benchmarks approaching minicomputer and mainframe performance); (2) ability to handle large design models of several hundred degrees of freedom, if necessary; and (3) broad extensibility through user-defined functions. To characterize MATLAB capabilities, a simplified design example is presented. This involves interactive definition of an observer-based state-space compensator for a flexible missile autopilot design task. MATLAB capabilities and limitations, in the context of this design task, are then summarized.

  2. Toward the optimization of PC-based training

    NASA Astrophysics Data System (ADS)

    Cho, Kohei; Murai, Shunji

    Since 1992, the National Space Development Agency of Japan (NASDA) and the Economic and Social Commission for Asia and the Pacific (ESCAP) have been co-organising the Regional Remote Sensing Seminar on Tropical Ecosystem Management (Program Chairman: Prof. Shunji Murai) every year in some country in Asia. In these seminars, the members of the ISPRS Working Group VI/2 'Computer Assisted Teaching' have been performing a PC-based hands-on-training on remote sensing and GIS for beginners. The main objective of the training was to transfer not only knowledge but also the technology of remote sensing and GIS to the beginners. The software and CD-ROM data set provided at the training were well designed not only for training but also for practical data analysis. This paper presents an outline of the training and discusses the optimisation of PC-based training for remote sensing and GIS.

  3. Tablet PC Enabled Body Sensor System for Rural Telehealth Applications

    PubMed Central

    Panicker, Nitha V.; Kumar, A. Sukesh

    2016-01-01

    Telehealth systems benefit from the rapid growth of mobile communication technology for measuring physiological signals. Development and validation of a tablet PC enabled noninvasive body sensor system for rural telehealth application are discussed in this paper. This system includes real time continuous collection of physiological parameters (blood pressure, pulse rate, and temperature) and fall detection of a patient with the help of a body sensor unit and wireless transmission of the acquired information to a tablet PC handled by the medical staff in a Primary Health Center (PHC). Abnormal conditions are automatically identified and alert messages are given to the medical officer in real time. Clinical validation is performed in a real environment and found to be successful. Bland-Altman analysis is carried out to validate the wrist blood pressure sensor used. The system works well for all measurements. PMID:26884757

  4. Underwater magnetic gradiometer for magnetic anomaly detection, localization, and tracking

    NASA Astrophysics Data System (ADS)

    Kumar, S.; Sulzberger, G.; Bono, J.; Skvoretz, D.; Allen, G. I.; Clem, T. R.; Ebbert, M.; Bennett, S. L.; Ostrom, R. K.; Tzouris, A.

    2007-04-01

    GE Security and the Naval Surface Warfare Center, Panama City (NSWC-PC) have collaborated to develop a magnetic gradiometer, called the Real-time Tracking Gradiometer or RTG that is mounted inside an unmanned underwater vehicle (UUV). The RTG is part of a buried mine hunting platform being developed by the United States Navy. The RTG has been successfully used to make test runs on mine-like targets buried off the coast of Florida. We will present a general description of the system and latest results describing system performance. This system can be also potentially used for other applications including those in the area of Homeland Security.

  5. Tracking of deformable objects

    NASA Astrophysics Data System (ADS)

    Aswani, Parimal; Wong, K. K.; Chong, Man N.

    2000-12-01

    Tracking of moving-objects in image sequences is needed for several video processing applications such as content-based coding, object oriented compression, object recognition and more recently for video object plane extraction in MPEG-4 coding. Tracking is a natural follow-up of motion-based segmentation. It is a fast and efficient method to achieve coherent motion segments along the temporal axis. Segmenting out moving objects for each and every frame in a video sequence is a computationally expensive approach. Thus, for better performance, semi-automatic segmentation is an acceptable compromise as automatic segmentation approaches rely heavily on prior assumptions. In semi-automatic segmentation approaches, motion-segmentation is performed only on the initial frame and the moving object is tracked in subsequent frames using tracking algorithms. In this paper, a new model for object tracking is proposed, where the image features -- edges, intensity pattern, object motion and initial keyed-in contour (by the user) form the prior and likelihood model of a Markov Random Field (MRF) model. Iterated Conditional Mode (ICM) is used for the minimization of the global energy for the MRF model. The motion segment for each frame is initialized using the segment information from the previous frame. For the initial frame, the motion segment is obtained by manually keying in the object contour. The motion-segments obtained using the proposed model are coherent and accurate. Experimental results on tracking using the proposed algorithm for different sequences -- Bream, Alexis and Claire are presented in this paper. The results obtained are accurate and can be used for a variety of applications including MPEG-4 Video Object Plane (VOP) extraction.

  6. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2002-07-30

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NO{sub x} emissions to 0.15 lb/million Btu or less without post-combustion flue gas cleaning. Work during previous reporting periods completed the design, installation, shakedown and initial PRB coal testing of a 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Based on these results, modifications to the gas-fired preheat combustor and PC burner were defined, along with a modified testing plan and schedule. During the current reporting period, a revised subcontract was executed with BBP to reflect changes in the pilot testing program. Modeling activities were continued to develop and verify revised design approaches for both the Preheat gas combustor and PC burner. Reactivation of the pilot test system was begun with BBP personnel. A presentation on the project results to date was given at the NETL-sponsored 2002 Conference on SCR and SNCR for NO{sub x} Control on May 15-16, 2002 in Pittsburgh PA. The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to make this technology ready for full-scale commercial deployment in order to meet an anticipated market demand for NO{sub x} reduction technologies resulting from the EPA's NO{sub x} SIP call.

  7. Teaching mathematics in the PC lab - the students' viewpoints

    NASA Astrophysics Data System (ADS)

    Schmidt, Karsten; Köhler, Anke

    2013-04-01

    The Matrix Algebra portion of the intermediate mathematics course at the Schmalkalden University Faculty of Business and Economics has been moved from a traditional classroom setting to a technology-based setting in the PC lab. A Computer Algebra System license was acquired that also allows its use on the students' own PCs. A survey was carried out to analyse the students' attitudes towards the use of technology in mathematics teaching.

  8. Implications of a J{sup PC} exotic

    SciTech Connect

    P.R. Page

    1997-09-01

    Recent experimental data from BNL on the isovector J{sup PC} = 1{sup {-+}} exotic at 1.6 GeV indicate the existence of a non-quarkonium state consistent with lattice gauge theory predictions. The authors discuss how further experiments can strengthen this conclusion. They show that the {rho}{pi}, {eta}{prime}{pi} and {eta}{pi} couplings of this state qualitatively support the hypothesis that it is a hybrid meson, although other interpretations cannot be eliminated.

  9. A PC-Based Controller for Dextrous Arms

    NASA Technical Reports Server (NTRS)

    Fiorini, Paolo; Seraji, Homayoun; Long, Mark

    1996-01-01

    This paper describes the architecture and performance of a PC-based controller for 7-DOF dextrous manipulators. The computing platform is a 486-based personal computer equipped with a bus extender to access the robot Multibus controller, together with a single board computer as the graphical engine, and with a parallel I/O board to interface with a force-torque sensor mounted on the manipulator wrist.

  10. Falling PC Solitaire Cards: An Open-Inquiry Approach

    ERIC Educational Resources Information Center

    Gonzalez-Espada, Wilson J.

    2012-01-01

    Many of us have played the PC Solitaire game that comes as standard software in many computers. Although I am not a great player, occasionally I win a game or two. The game celebrates my accomplishment by pushing the cards forward, one at a time, falling gracefully in what appears to look like a parabolic path in a drag-free environment. One day,…

  11. Practical Pocket PC Application w/Biometric Security

    NASA Technical Reports Server (NTRS)

    Logan, Julian

    2004-01-01

    I work in the Flight Software Engineering Branch, where we provide design and development of embedded real-time software applications for flight and supporting ground systems to support the NASA Aeronautics and Space Programs. In addition, this branch evaluates, develops and implements new technologies for embedded real-time systems, and maintains a laboratory for applications of embedded technology. The majority of microchips that are used in modern society have been programmed using embedded technology. These small chips can be found in microwaves, calculators, home security systems, cell phones and more. My assignment this summer entails working with an iPAQ HP 5500 Pocket PC. This top-of-the-line hand-held device is one of the first mobile PC's to introduce biometric security capabilities. Biometric security, in this case a fingerprint authentication system, is on the edge of technology as far as securing information. The benefits of fingerprint authentication are enormous. The most significant of them are that it is extremely difficult to reproduce someone else's fingerprint, and it is equally difficult to lose or forget your own fingerprint as opposed to a password or pin number. One of my goals for this summer is to integrate this technology with another Pocket PC application. The second task for the summer is to develop a simple application that provides an Astronaut EVA (Extravehicular Activity) Log Book capability. The Astronaut EVA Log Book is what an astronaut would use to report the status of field missions, crew physical health, successes, future plans, etc. My goal is to develop a user interface into which these data fields can be entered and stored. The applications that I am developing are created using eMbedded Visual C++ 4.0 with the Pocket PC 2003 Software Development Kit provided by Microsoft.

  12. Automatic crack propagation tracking

    NASA Technical Reports Server (NTRS)

    Shephard, M. S.; Weidner, T. J.; Yehia, N. A. B.; Burd, G. S.

    1985-01-01

    A finite element based approach to fully automatic crack propagation tracking is presented. The procedure presented combines fully automatic mesh generation with linear fracture mechanics techniques in a geometrically based finite element code capable of automatically tracking cracks in two-dimensional domains. The automatic mesh generator employs the modified-quadtree technique. Crack propagation increment and direction are predicted using a modified maximum dilatational strain energy density criterion employing the numerical results obtained by meshes of quadratic displacement and singular crack tip finite elements. Example problems are included to demonstrate the procedure.

  13. Hazardous waste tracking issues

    SciTech Connect

    Marvin, R. )

    1993-08-01

    The concept of cradle-to-grave oversight of hazardous waste was established in 1976 under RCRA. Since then, the multicopy Uniform Hazardous Waste Manifest has been a key component in the federal tracking system. The manifests ensure that generators, transporters and TSDFs maintain documentation of hazardous waste shipments. To a large extent, the tracking system has served its intended purpose; nevertheless, certain shortcomings exist. Anyone involved in shipping hazardous waste should be aware of the system's weaknesses and take appropriate measures to compensate for them.

  14. CTS. Commitment Tracking System

    SciTech Connect

    Stucki, F.K.

    1992-06-01

    CTS is a micro based prototype of the data elements, screens, and information processing rules that apply to the Commitment and Non-compliance Tracking Program. The system is focused on the non-compliance or commitment. When some group is out of compliance they need a way of tracking that occurrence. The system must be able to CRUD (Create, Retrieve, Update, Delete) instances of the non-compliance Event. Additionally, the system must provide data integrity. This is done through a set up of tables and data validation.

  15. Simple front tracking

    SciTech Connect

    Glimm, J.; Grove, J.W.; Li, X.; Zhao, N.

    1999-04-01

    A new and simplified front tracking algorithm has been developed as an aspect of the extension of this algorithm to three dimensions. Here the authors emphasize two main results: (1) a simplified description of the microtopology of the interface, based on interface crossings with cell block edges, and (2) an improved algorithm for the interaction of a tracked contact discontinuity with an untracked shock wave. For the latter question, they focus on the post interaction jump at the contact, which is a purely 1D issue. Comparisons to other methods, including the level set method, are included.

  16. Spin tracking in RHIC

    SciTech Connect

    Luccio, A.U.; Katayama, T.; Wu, H.

    1997-07-01

    In the acceleration of polarized protons in RHIC many spin depolarizing resonances are encountered. Helical Siberian snakes will be used to overcome depolarizing effects. The behavior of polarization can be studied by numerical tracking in a model accelerator. That allows one to check the strength of the resonances, to study the effect of snakes, to find safe lattice tune regions, and finally to study the operation of special devices like spin flippers. In this paper the authors describe numerical spin tracking. Results show that, for the design corrected distorted orbit and the design beam emittance, the polarization of the beam will be preserved in the whole range of proton energies in RHIC.

  17. PC/AT-based architecture for shared telerobotic control

    NASA Astrophysics Data System (ADS)

    Schinstock, Dale E.; Faddis, Terry N.; Barr, Bill G.

    1993-03-01

    A telerobotic control system must include teleoperational, shared, and autonomous modes of control in order to provide a robot platform for incorporating the rapid advances that are occurring in telerobotics and associated technologies. These modes along with the ability to modify the control algorithms are especially beneficial for telerobotic control systems used for research purposes. The paper describes an application of the PC/AT platform to the control system of a telerobotic test cell. The paper provides a discussion of the suitability of the PC/AT as a platform for a telerobotic control system. The discussion is based on the many factors affecting the choice of a computer platform for a real time control system. The factors include I/O capabilities, simplicity, popularity, computational performance, and communication with external systems. The paper also includes a description of the actuation, measurement, and sensor hardware of both the master manipulator and the slave robot. It also includes a description of the PC-Bus interface cards. These cards were developed by the researchers in the KAT Laboratory, specifically for interfacing to the master manipulator and slave robot. Finally, a few different versions of the low level telerobotic control software are presented. This software incorporates shared control by supervisory systems and the human operator and traded control between supervisory systems and the human operator.

  18. Capsaicin induces apoptosis in PC12 cells through ER stress.

    PubMed

    Krizanova, Olga; Steliarova, Iveta; Csaderova, Lucia; Pastorek, Michal; Hudecova, Sona

    2014-02-01

    Capsaicin, the pungent agent in chili peppers, has been shown to act as a tumor-suppressor in cancer. In our previous study, capsaicin was shown to induce apoptosis in the rat pheochromocytoma cell line (PC12 cells). Thus, the aim of the present study was to determine the potential mechanism by which capsaicin induces apoptosis. We treated PC12 cells with 50, 100 and 500 µM capsaicin and measured the reticular calcium content and expression of the reticular calcium transport systems. These results were correlated with endoplasmic reticulum (ER) stress markers CHOP, ATF4 and X-box binding protein 1 (XBP1), as well as with apoptosis induction. We observed that capsaicin decreased reticular calcium in a concentration-dependent manner. Simultaneously, expression levels of the sarco/endoplasmic reticulum pump and ryanodin receptor of type 2 were modified. These changes were accompanied by increased ER stress, as documented by increased stress markers. Thus, from these results we propose that in PC12 cells capsaicin induces apoptosis through increased ER stress. PMID:24337105

  19. Hypergravity Stimulation Enhances PC12 Neuron-Like Cell Differentiation

    PubMed Central

    2015-01-01

    Altered gravity is a strong physical cue able to elicit different cellular responses, representing a largely uninvestigated opportunity for tissue engineering/regenerative medicine applications. Our recent studies have shown that both proliferation and differentiation of C2C12 skeletal muscle cells can be enhanced by hypergravity treatment; given these results, PC12 neuron-like cells were chosen to test the hypothesis that hypergravity stimulation might also affect the behavior of neuronal cells, in particular promoting an enhanced differentiated phenotype. PC12 cells were thus cultured under differentiating conditions for either 12 h or 72 h before being stimulated with different values of hypergravity (50 g and 150 g). Effects of hypergravity were evaluated at transcriptional level 1 h and 48 h after the stimulation, and at protein level 48 h from hypergravity exposure, to assess its influence on neurite development over increasing differentiation times. PC12 differentiation resulted strongly affected by the hypergravity treatments; in particular, neurite length was significantly enhanced after exposure to high acceleration values. The achieved results suggest that hypergravity might induce a faster and higher neuronal differentiation and encourage further investigations on the potential of hypergravity in the preparation of cellular constructs for regenerative medicine and tissue engineering purposes. PMID:25785273

  20. Hypergravity stimulation enhances PC12 neuron-like cell differentiation.

    PubMed

    Genchi, Giada Graziana; Cialdai, Francesca; Monici, Monica; Mazzolai, Barbara; Mattoli, Virgilio; Ciofani, Gianni

    2015-01-01

    Altered gravity is a strong physical cue able to elicit different cellular responses, representing a largely uninvestigated opportunity for tissue engineering/regenerative medicine applications. Our recent studies have shown that both proliferation and differentiation of C2C12 skeletal muscle cells can be enhanced by hypergravity treatment; given these results, PC12 neuron-like cells were chosen to test the hypothesis that hypergravity stimulation might also affect the behavior of neuronal cells, in particular promoting an enhanced differentiated phenotype. PC12 cells were thus cultured under differentiating conditions for either 12 h or 72 h before being stimulated with different values of hypergravity (50 g and 150 g). Effects of hypergravity were evaluated at transcriptional level 1 h and 48 h after the stimulation, and at protein level 48 h from hypergravity exposure, to assess its influence on neurite development over increasing differentiation times. PC12 differentiation resulted strongly affected by the hypergravity treatments; in particular, neurite length was significantly enhanced after exposure to high acceleration values. The achieved results suggest that hypergravity might induce a faster and higher neuronal differentiation and encourage further investigations on the potential of hypergravity in the preparation of cellular constructs for regenerative medicine and tissue engineering purposes.

  1. FORECAST: Regulatory effects cost analysis software manual -- Version 4.1. Revision 1

    SciTech Connect

    Lopez, B.; Sciacca, F.W.

    1996-07-01

    The FORECAST program was developed to facilitate the preparation of the value-impact portion of NRC regulatory analyses. This PC program integrates the major cost and benefit considerations that may result from a proposed regulatory change. FORECAST automates much of the calculations typically needed in a regulatory analysis and thus reduces the time and labor required to perform these analyses. More importantly, its integrated and consistent treatment of the different value-impact considerations should help assure comprehensiveness, uniformity, and accuracy in the preparation of NRC regulatory analyses. The Current FORECAST Version 4.1 has been upgraded from the previous version and now includes an uncertainty package, an automatic cost escalation package, and other improvements. In addition, it now explicitly addresses public health impacts, occupational health impacts, onsite property damage, and government costs. Thus, FORECAST Version 4.1 can treat all attributes normally quantified in a regulatory analysis.

  2. PDT - PARTICLE DISPLACEMENT TRACKING SOFTWARE

    NASA Technical Reports Server (NTRS)

    Wernet, M. P.

    1994-01-01

    Particle Imaging Velocimetry (PIV) is a quantitative velocity measurement technique for measuring instantaneous planar cross sections of a flow field. The technique offers very high precision (1%) directionally resolved velocity vector estimates, but its use has been limited by high equipment costs and complexity of operation. Particle Displacement Tracking (PDT) is an all-electronic PIV data acquisition and reduction procedure which is simple, fast, and easily implemented. The procedure uses a low power, continuous wave laser and a Charged Coupled Device (CCD) camera to electronically record the particle images. A frame grabber board in a PC is used for data acquisition and reduction processing. PDT eliminates the need for photographic processing, system costs are moderately low, and reduced data are available within seconds of acquisition. The technique results in velocity estimate accuracies on the order of 5%. The software is fully menu-driven from the acquisition to the reduction and analysis of the data. Options are available to acquire a single image or 5- or 25-field series of images separated in time by multiples of 1/60 second. The user may process each image, specifying its boundaries to remove unwanted glare from the periphery and adjusting its background level to clearly resolve the particle images. Data reduction routines determine the particle image centroids and create time history files. PDT then identifies the velocity vectors which describe the particle movement in the flow field. Graphical data analysis routines are included which allow the user to graph the time history files and display the velocity vector maps, interpolated velocity vector grids, iso-velocity vector contours, and flow streamlines. The PDT data processing software is written in FORTRAN 77 and the data acquisition routine is written in C-Language for 80386-based IBM PC compatibles running MS-DOS v3.0 or higher. Machine requirements include 4 MB RAM (3 MB Extended), a single or

  3. Knockdown of NogoA prevents MPP+‑induced neurotoxicity in PC12 cells via the mTOR/STAT3 signaling pathway.

    PubMed

    Zhong, Jianbin; Li, Xie; Wan, Limei; Chen, Zhibang; Zhong, Simin; Xiao, Songhua; Yan, Zhengwen

    2016-02-01

    NogoA is a myelin‑associated protein, which is important in the inhibition of axonal fiber growth and in regeneration following injury of the mammalian central nervous system. A previous study suggested that NogoA may be key in the process of Parkinson's disease (PD), which is the second most common chronic neurodegenerative disorder worldwide. The regulatory mechanism underlying the effect of NogoA on the process of PD remains to be fully elucidated. The present study aimed to investigate the effect and underlying mechanism of NogoA on cellular viability, apoptosis and autophagy induced by 1-methyl-4-phenylpyridinium (MPP+) in PC12 cells, a commonly used in vitro PD model. PC12 cells were treated with 1 mM MPP+ for 24 h and the cells were harvested for western blotting. The results demonstrated that the protien expression levels of NogoA were increased in the PC12 cells treated with MPP+. Subsequently, NogoA small interfering RNA was synthesized and transfected into PC12 cells to silence the expression of NogoA. NogoA knockdown significantly reduced the MPP+‑induced decrease in cell viability and apoptosis, detected using a cell counting kit‑8 and flow cytometric analysis, respectively. Interference in the expression of NogoA increased the MPP+‑induced decrease in mitochondrial membrane potential, determined quantitatively by flow cytometry using JC-1 dye, and the protein levels of Beclin‑1. In addition, MPP+ treatment activated the mammalian target of rapamycin (mTOR)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Knockdown of NogoA significantly inhibited the expression levels of mTOR and STAT3. Furthermore, overexpression of NogoA had similar neurotoxic effects on the PC12 cells as MPP+ treatment. Treatment with rapamycin, an inhibitor of the mTOR/STAT3 signaling pathway had a similar effect to that of NogoA knockdown in the MPP+‑treated PC12 cells. Taken together, the results from the present study demonstrated that

  4. Engineering cell-fluorescent ion track hybrid detectors

    PubMed Central

    2013-01-01

    Background The lack of sensitive biocompatible particle track detectors has so far limited parallel detection of physical energy deposition and biological response. Fluorescent nuclear track detectors (FNTDs) based on Al2O3:C,Mg single crystals combined with confocal laser scanning microscopy (CLSM) provide 3D information on ion tracks with a resolution limited by light diffraction. Here we report the development of next generation cell-fluorescent ion track hybrid detectors (Cell-Fit-HD). Methods The biocompatibility of FNTDs was tested using six different cell lines, i.e. human non-small cell lung carcinoma (A549), glioblastoma (U87), androgen independent prostate cancer (PC3), epidermoid cancer (A431) and murine (VmDk) glioma SMA-560. To evaluate cell adherence, viability and conformal coverage of the crystals different seeding densities and alternative coating with extracellular matrix (fibronectin) was tested. Carbon irradiation was performed in Bragg peak (initial 270.55 MeV u−1). A series of cell compartment specific fluorescence stains including nuclear (HOECHST), membrane (Glut-1), cytoplasm (Calcein AM, CM-DiI) were tested on Cell-Fit-HDs and a single CLSM was employed to co-detect the physical (crystal) as well as the biological (cell layer) information. Results The FNTD provides a biocompatible surface. Among the cells tested, A549 cells formed the most uniform, viable, tightly packed epithelial like monolayer. The ion track information was not compromised in Cell-Fit-HD as compared to the FNTD alone. Neither cell coating and culturing, nor additional staining procedures affected the properties of the FNTD surface to detect ion tracks. Standard immunofluorescence and live staining procedures could be employed to co-register cell biology and ion track information. Conclusions The Cell-Fit-Hybrid Detector system is a promising platform for a multitude of studies linking biological response to energy deposition at high level of optical microscopy

  5. General defocusing particle tracking.

    PubMed

    Barnkob, Rune; Kähler, Christian J; Rossi, Massimiliano

    2015-09-01

    A General Defocusing Particle Tracking (GDPT) method is proposed for tracking the three-dimensional motion of particles in Lab-on-a-chip systems based on a set of calibration images and the normalized cross-correlation function. In comparison with other single-camera defocusing particle-tracking techniques, GDPT possesses a series of key advantages: it is applicable to particle images of arbitrary shapes, it is intuitive and easy to use, it can be used without advanced knowledge of optics and velocimetry theory, it is robust against outliers and overlapping particle images, and it requires only equipment which is standard in microfluidic laboratories. We demonstrate the method by tracking the three-dimensional motion of 2 μm spherical particles in a microfluidic channel using three different optical arrangements. The position of the particles was measured with an estimated uncertainty of 0.1 μm in the in-plane direction and 2 μm in the depth direction for a measurement volume of 1510 × 1270 × 160 μm(3). A ready-to-use GUI implementation of the method can be acquired on . PMID:26201498

  6. Personal Tracking Charts

    MedlinePlus

    ... only on Monday, Wednesday, and Friday. Keep an eye out for allergic reactions. I should take Prezista with food. year keeping track of my periods month mark the Type of Flow in the boxes below L =exceptionally light N =normal h =exceptionally heavy S =spotting O =none ...

  7. Dust Devil Tracks

    NASA Technical Reports Server (NTRS)

    2002-01-01

    (Released 8 May 2002) The Science This image, centered near 50.0 S and 17.7 W displays dust devil tracks on the surface. Most of the lighter portions of the image likely have a thin veneer of dust settled on the surface. As a dust devil passes over the surface, it acts as a vacuum and picks up the dust, leaving the darker substrate exposed. In this image there is a general trend of many of the tracks running from east to west or west to east, indicating the general wind direction. There is often no general trend present in dust devil tracks seen in other images. The track patterns are quite ephemeral and can completely change or even disappear over the course of a few months. Dust devils are one of the mechanisms that Mars uses to constantly pump dust into the ubiquitously dusty atmosphere. This atmospheric dust is one of the main driving forces of the present Martian climate. The Story Vrrrrooooooooom. Think of a tornado, the cartoon Tasmanian devil, or any number of vacuum commercials that powerfully suck up swirls of dust and dirt. That's pretty much what it's like on the surface of Mars a lot of the time. Whirlpools of wind called

  8. Tracking Self into Place

    ERIC Educational Resources Information Center

    Piersol, Laura

    2010-01-01

    In an effort to figure out what it means to educate "ecologically," I decided to track down some of the stories that I was living, telling and making as an educator. I ended up lost in the house of environmental education, stuck within the rooms of ecological science and political advocacy. Outside on the lawn sat the story of place based…

  9. Energy Tracking Diagrams

    ERIC Educational Resources Information Center

    Scherr, Rachel E.; Harrer, Benedikt W.; Close, Hunter G.; Daane, Abigail R.; DeWater, Lezlie S.; Robertson, Amy D.; Seeley, Lane; Vokos, Stamatis

    2016-01-01

    Energy is a crosscutting concept in science and features prominently in national science education documents. In the "Next Generation Science Standards," the primary conceptual learning goal is for learners to conserve energy as they "track" the transfers and transformations of energy within, into, or out of the system of…

  10. Tracking Politics with POWER

    ERIC Educational Resources Information Center

    Moreira, Silvio; Batista, David S.; Carvalho, Paula; Couto, Francisco M.; Silva, Mario J.

    2013-01-01

    Purpose: POWER is an ontology of political processes and entities. It is designed for tracking politicians, political organizations and elections, both in mainstream and social media. The aim of this paper is to propose a data model to describe political agents and their relations over time. Design/methodology/approach: The authors propose a data…

  11. TRACKING Trounces Test Scores

    ERIC Educational Resources Information Center

    Education Digest: Essential Readings Condensed for Quick Review, 2004

    2004-01-01

    This article presents an adaptation of an article from School Board News, January 6, 2004 edition. The article describes the effort of de-tracking students of varying ability levels, made by officials of South Side High School, in Rockville Centre, New York, and Noble High School, in North Berwick, Maine. Officials from both schools say that the…

  12. Tracking Speech Sound Acquisition

    ERIC Educational Resources Information Center

    Powell, Thomas W.

    2011-01-01

    This article describes a procedure to aid in the clinical appraisal of child speech. The approach, based on the work by Dinnsen, Chin, Elbert, and Powell (1990; Some constraints on functionally disordered phonologies: Phonetic inventories and phonotactics. "Journal of Speech and Hearing Research", 33, 28-37), uses a railway idiom to track gains in…

  13. An overview of the evaluation plan for PC/MISI: PC-based Multiple Information System Interface

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Lim, Bee Lee; Hall, Philip P.

    1985-01-01

    An initial evaluation plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intend to be used as a blueprint for the evaluation of this system. Each objective of the design project is discussed along with the evaluation parameters and methodology to be used in the evaluation of the implementation's achievement of those objectives. The potential of the system for research activities related to more general aspects of information retrieval is also discussed.

  14. GEOS-3 Doppler difference tracking

    NASA Technical Reports Server (NTRS)

    Rosenbaum, B.

    1977-01-01

    The Doppler difference method as applied to track the GEOS 3 spacecraft is discussed. In this method a pair of 2 GHz ground tracking stations simultaneously track a spacecraft beacon to generate an observable signal in which bias and instability of the carrier frequency cancel. The baselines are formed by the tracking sites at Bermuda, Rosman, and Merritt Island. Measurements were made to evaluate the effectiveness of the Doppler differencing procedure in tracking a beacon target with the high dynamic rate of the GEOS 3 orbit. Results indicate the precision of the differenced data to be at a level comparable to the conventional precise two way Doppler tracking.

  15. Adaptive DIT-Based Fringe Tracking and Prediction at IOTA

    NASA Technical Reports Server (NTRS)

    Wilson, Edward; Pedretti, Ettore; Bregman, Jesse; Mah, Robert W.; Traub, Wesley A.

    2004-01-01

    An automatic fringe tracking system has been developed and implemented at the Infrared Optical Telescope Array (IOTA). In testing during May 2002, the system successfully minimized the optical path differences (OPDs) for all three baselines at IOTA. Based on sliding window discrete Fourier transform (DFT) calculations that were optimized for computational efficiency and robustness to atmospheric disturbances, the algorithm has also been tested extensively on off-line data. Implemented in ANSI C on the 266 MHZ PowerPC processor running the VxWorks real-time operating system, the algorithm runs in approximately 2.0 milliseconds per scan (including all three interferograms), using the science camera and piezo scanners to measure and correct the OPDs. Preliminary analysis on an extension of this algorithm indicates a potential for predictive tracking, although at present, real-time implementation of this extension would require significantly more computational capacity.

  16. GPS Metric Tracking Unit

    NASA Technical Reports Server (NTRS)

    2008-01-01

    As Global Positioning Satellite (GPS) applications become more prevalent for land- and air-based vehicles, GPS applications for space vehicles will also increase. The Applied Technology Directorate of Kennedy Space Center (KSC) has developed a lightweight, low-cost GPS Metric Tracking Unit (GMTU), the first of two steps in developing a lightweight, low-cost Space-Based Tracking and Command Subsystem (STACS) designed to meet Range Safety's link margin and latency requirements for vehicle command and telemetry data. The goals of STACS are to improve Range Safety operations and expand tracking capabilities for space vehicles. STACS will track the vehicle, receive commands, and send telemetry data through the space-based asset, which will dramatically reduce dependence on ground-based assets. The other step was the Low-Cost Tracking and Data Relay Satellite System (TDRSS) Transceiver (LCT2), developed by the Wallops Flight Facility (WFF), which allows the vehicle to communicate with a geosynchronous relay satellite. Although the GMTU and LCT2 were independently implemented and tested, the design collaboration of KSC and WFF engineers allowed GMTU and LCT2 to be integrated into one enclosure, leading to the final STACS. In operation, GMTU needs only a radio frequency (RF) input from a GPS antenna and outputs position and velocity data to the vehicle through a serial or pulse code modulation (PCM) interface. GMTU includes one commercial GPS receiver board and a custom board, the Command and Telemetry Processor (CTP) developed by KSC. The CTP design is based on a field-programmable gate array (FPGA) with embedded processors to support GPS functions.

  17. Characterization of μ-oxo-(BsubPc)2 in Multiple Organic Photovoltaic Device Architectures: Comparing against and Combining with Cl-BsubPc.

    PubMed

    Castrucci, Jeffrey S; Garner, Richard K; Dang, Jeremy D; Thibau, Emmanuel; Lu, Zheng-Hong; Bender, Timothy P

    2016-09-21

    We demonstrate the first application of a unique boron subphthalocyanine (BsubPc) derivative, the oxygen bridged dimer μ-oxo-(BsubPc)2, as a multifunctional material within planar heterojunction organic photovoltaic (OPV) devices. We first explored the pairing of μ-oxo-(BsubPc)2 with well-known electron accepting and electron donating materials to explore its basic functionality. These preliminary device structures and metrics indicated that μ-oxo-(BsubPc)2 is best applied as an electron donating material when used in simple bilayer structures, as it yielded comparable OPV device efficiencies to that of the more well-established and highly optimized chloro-boron subphthalocyanine (Cl-BsubPc) OPV device structures. Thereafter we established that the HOMO/LUMO energy levels of μ-oxo-(BsubPc)2 are well-placed to apply it as a bifunctional donor/acceptor interlayer material in both energy and charge cascade OPV device architectures. Within this context, we found that μ-oxo-(BsubPc)2 was particularly effective in a charge cascade device as an interlayer between Cl-BsubPc and C70. We finally found evidence of an alloying-like effect for devices with mixed electron donor layers of (Cl-BsubPc) and μ-oxo-(BsubPc)2, achieved through co-deposition. The overarching conclusion is therefore that μ-oxo-(BsubPc)2 has the ability to improve the performance of Cl-BsubPc OPV devices and is a multifunctional material worthy of further study.

  18. Characterization of μ-oxo-(BsubPc)2 in Multiple Organic Photovoltaic Device Architectures: Comparing against and Combining with Cl-BsubPc.

    PubMed

    Castrucci, Jeffrey S; Garner, Richard K; Dang, Jeremy D; Thibau, Emmanuel; Lu, Zheng-Hong; Bender, Timothy P

    2016-09-21

    We demonstrate the first application of a unique boron subphthalocyanine (BsubPc) derivative, the oxygen bridged dimer μ-oxo-(BsubPc)2, as a multifunctional material within planar heterojunction organic photovoltaic (OPV) devices. We first explored the pairing of μ-oxo-(BsubPc)2 with well-known electron accepting and electron donating materials to explore its basic functionality. These preliminary device structures and metrics indicated that μ-oxo-(BsubPc)2 is best applied as an electron donating material when used in simple bilayer structures, as it yielded comparable OPV device efficiencies to that of the more well-established and highly optimized chloro-boron subphthalocyanine (Cl-BsubPc) OPV device structures. Thereafter we established that the HOMO/LUMO energy levels of μ-oxo-(BsubPc)2 are well-placed to apply it as a bifunctional donor/acceptor interlayer material in both energy and charge cascade OPV device architectures. Within this context, we found that μ-oxo-(BsubPc)2 was particularly effective in a charge cascade device as an interlayer between Cl-BsubPc and C70. We finally found evidence of an alloying-like effect for devices with mixed electron donor layers of (Cl-BsubPc) and μ-oxo-(BsubPc)2, achieved through co-deposition. The overarching conclusion is therefore that μ-oxo-(BsubPc)2 has the ability to improve the performance of Cl-BsubPc OPV devices and is a multifunctional material worthy of further study. PMID:27548372

  19. Multi-satellite study of the excitation of Pc3 and Pc4-5 ULF waves and their penetration across the plasmapause during the 2003 Halloween superstorm

    NASA Astrophysics Data System (ADS)

    Balasis, G.; Daglis, I. A.; Mann, I. R.; Papadimitriou, C.; Zesta, E.; Georgiou, M.; Haagmans, R.; Tsinganos, K.

    2015-10-01

    We use multi-satellite and ground-based magnetic data to investigate the concurrent characteristics of Pc3 (22-100 mHz) and Pc4-5 (1-22 mHz) ultra-low-frequency (ULF) waves on the 31 October 2003 during the Halloween magnetic superstorm. ULF waves are seen in the Earth's magnetosphere, topside ionosphere, and Earth's surface, enabling an examination of their propagation characteristics. We employ a time-frequency analysis technique and examine data from when the Cluster and CHAMP spacecraft were in good local time (LT) conjunction near the dayside noon-midnight meridian. We find clear evidence of the excitation of both Pc3 and Pc4-5 waves, but more significantly we find a clear separation in the L shell of occurrence of the Pc4-5 and Pc3 waves in the equatorial inner magnetosphere, separated by the density gradients at the plasmapause boundary layer. A key finding of the wavelet spectral analysis of data collected from the Geotail, Cluster, and CHAMP spacecraft and the CARISMA and GIMA magnetometer networks was a remarkably clear transition of the waves' frequency into dominance in a higher-frequency regime within the Pc3 range. Analysis of the local field line resonance frequency suggests that the separation of the Pc4-5 and Pc3 emissions across the plasmapause is consistent with the structure of the inhomogeneous field line resonance Alfvén continuum. The Pc4-5 waves are consistent with direct excitation by the solar wind in the plasma trough, as well as Pc3 wave absorption in the plasmasphere following excitation by upstream waves originating at the bow shock in the local noon sector. However, despite good solar wind coverage, our study was not able to unambiguously identify a clear explanation for the sharp universal time (UT) onset of the discrete frequency and large-amplitude Pc3 wave power.

  20. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO2) monitor.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cutaneous carbon dioxide (PcCO2) monitor. 868.2480... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Monitoring Devices § 868.2480 Cutaneous carbon dioxide (PcCO2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive...

  1. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO 2) monitor.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cutaneous carbon dioxide (PcCO 2) monitor. 868... dioxide (PcCO 2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive... relative changes in a hemodynamically stable patient's cutaneous carbon dioxide tension as an adjunct...

  2. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO 2) monitor.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cutaneous carbon dioxide (PcCO 2) monitor. 868... dioxide (PcCO 2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive... relative changes in a hemodynamically stable patient's cutaneous carbon dioxide tension as an adjunct...

  3. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO2) monitor.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Cutaneous carbon dioxide (PcCO2) monitor. 868.2480... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Monitoring Devices § 868.2480 Cutaneous carbon dioxide (PcCO2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive...

  4. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO2) monitor.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Cutaneous carbon dioxide (PcCO2) monitor. 868.2480... (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Monitoring Devices § 868.2480 Cutaneous carbon dioxide (PcCO2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive...

  5. The USL NASA PC R and D project: General specifications of objectives

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor)

    1984-01-01

    Given here are the general specifications of the objectives of the University of Southwestern Louisiana Data Base Management System (USL/DBMS) NASA PC R and D Project, a project initiated to address future R and D issues related to PC-based processing environments acquired pursuant to the NASA contract work; namely, the IBM PC/XT systems.

  6. Viral complement regulatory proteins.

    PubMed

    Rosengard, A M; Ahearn, J M

    1999-05-01

    The inactivation of complement provides cells and tissues critical protection from complement-mediated attack and decreases the associated recruitment of other inflammatory mediators. In an attempt to evade the host immune response, viruses have evolved two mechanisms to acquire complement regulatory proteins. They can directly seize the host cell complement regulators onto their outer envelope and/or they can produce their own proteins which are either secreted into the neighboring intercellular space or expressed as membrane-bound proteins on the infected host cell. The following review will concentrate on the viral homologues of the mammalian complement regulatory proteins, specifically those containing complement control protein (CCP) repeats. PMID:10408371

  7. Rationales for regulatory activity

    SciTech Connect

    Perhac, R.M.

    1997-02-01

    The author provides an outline which touches on the types of concerns about risk evaluation which are addressed in the process of establishing regulatory guides. Broadly he says regulatory activity serves three broad constituents: (1) Paternalism (private risk); (2) Promotion of social welfare (public risks); (3) Protection of individual rights (public risks). He then discusses some of the major issues encountered in reaching a decision on what is an acceptable level of risk within each of these areas, and how one establishes such a level.

  8. Remote sensing of water tracks

    NASA Astrophysics Data System (ADS)

    Trochim, E. D.; Prakash, A.; Kane, D. L.; Romanovsky, V. E.

    2016-03-01

    Water tracks are an intrinsic part of the surficial drainage network in the foothills of the Brooks Range, Alaska. They preferentially transport water off hillslopes and represent the interplay between hydrology, vegetation, geomorphology, and permafrost characteristics. This research on mapping the location of water tracks builds on previous work which demonstrated that different types of water tracks exist due to difference primarily driven by geomorphology. We used a combination method where spectral classifications, texture, and topography were fed into random forests to identify the water track classes. The most accurate distributions were obtained for the organic-rich and wide water track classes. The distinct linear shapes of the water tracks could also be visualized for many of the classes, especially in areas where the water tracks were particularly discrete. The biggest challenges to mapping the water tracks were due to class imbalances and high variability within and overlapping between classes. This research presents a significant step forward in understanding periglacial landscape dynamics.

  9. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Riley, G.

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  10. AQUIS: A PC-based air quality and permit information system

    SciTech Connect

    Smith, A.E.; Huber, C.C.; Tschanz, J. ); Ryckman, J.S. Jr. )

    1992-01-01

    The Air Quality Utility Information System (AQUIS) was developed to calculate and track emissions, permits, and related information. The system runs on IBM-compatible personal computers using dBASE IV. AQUIS tracks more than 900 data items distributed among various source categories and allows the user to enter specific information on permit control devices, stacks, and related regulatory requirements. The system is currently operating at seven US Air Force Materiel Command facilities, large industrial operations involved in the repair and maintenance of aircraft. Environmental management personnel are responsible for the compliance status of as many as l,000 sources at each facility. The usefulness of the system has been enhanced by providing a flexible reporting capability that permits users who are unfamiliar with database structure to design and prepare reports containing specified information. In addition to the standard six pollutants, AQUIS calculates compound-specific emissions and allows users to enter their own emission estimates. This capability will be useful in developing air toxics inventories and control plans.

  11. AQUIS: A PC-based air quality and permit information system

    SciTech Connect

    Smith, A.E.; Huber, C.C.; Tschanz, J.; Ryckman, J.S. Jr.

    1992-09-01

    The Air Quality Utility Information System (AQUIS) was developed to calculate and track emissions, permits, and related information. The system runs on IBM-compatible personal computers using dBASE IV. AQUIS tracks more than 900 data items distributed among various source categories and allows the user to enter specific information on permit control devices, stacks, and related regulatory requirements. The system is currently operating at seven US Air Force Materiel Command facilities, large industrial operations involved in the repair and maintenance of aircraft. Environmental management personnel are responsible for the compliance status of as many as l,000 sources at each facility. The usefulness of the system has been enhanced by providing a flexible reporting capability that permits users who are unfamiliar with database structure to design and prepare reports containing specified information. In addition to the standard six pollutants, AQUIS calculates compound-specific emissions and allows users to enter their own emission estimates. This capability will be useful in developing air toxics inventories and control plans.

  12. Hydralazine rescues PC12 cells from acrolein-mediated death.

    PubMed

    Liu-Snyder, Peishan; Borgens, Richard Ben; Shi, Riyi

    2006-07-01

    Acrolein, a major lipid peroxidation product, has been associated with both CNS trauma and neurodegenerative diseases. Because of its long half-life, acrolein is a potent endogenous toxin capable of killing healthy cells during the secondary injury process. Traditionally, attempts to intervene in the process of progressive cell death after the primary injury have included scavenging reactive oxygen species (so-called free radicals). The animal data supporting such an approach have generally been positive, but all human clinical trials attempting a similar outcome in human CNS injury have failed. New drugs that might reduce toxicity by scavenging the products of lipid peroxidation present a promising, and little investigated, therapeutic approach. Hydralazine, a well-known treatment for hypertension, has been reported to react with acrolein, forming hydrazone in cell-free systems. In the companion paper, we have established an acrolein-mediated cell injury model using PC12 cells in vitro. Here we test the hypothesis that the formation of hydrazone adducts with acrolein is able to reduce acrolein toxicity and spare a significant percentage of the population of PC12 cells from death. Concentrations of approximately 1 mM of this aldehyde scavenger can rescue over 80% of the population of PC12 cells. This study provides a basis for a new pharmacological treatment to reduce the effects of secondary injury in the damaged and/or diseased nervous system. In particular, we describe the need for new drugs that possess aldehyde scavenging properties but do not interfere with the regulation of blood pressure.

  13. Ionospheric signatures of cusp latitude Pc 3 pulsations

    SciTech Connect

    Engebretson, M.J.; Anderson, B.J. ); Cahill, L.J. Jr. ); Arnoldy, R.L. ); Rosenberg, T.J. ); Carpenter, D.L. ); Gail, W.B. ); Eather, R.H. )

    1990-03-01

    The authors have compared search coil magnetometer, riometer, photometer, and ELF-VLF receiver data obtained at South Pole Station and McMurdo, Antarctica, during selected days in March and April 1986. Narrow-band magnetic pulsations in the Pc 3 period range are observed simultaneously at both stations in the dayside sector during times of low interplanetary magnetic field (IMF) cone angle, but are considerably stronger at South Pole, which is located at a latitude near the nominal foot point of the daysie cusp/cleft region. Pulsations in auroral light a 427.8 nm wavelength are often observed with magnetic pulsations at South Pole, but such optical pulsations are not observed at McMurdo. When Pc 3 pulsations are present, they exhibit nearly identical frequencies, proportional to the magnitude of the IMF, in magnetometer, photometer, and ELF-VLF receiver signals at South Pole Station and in magnetometer signals at McMurdo. Singals from the 30-MHz riometer at South Pole are modulated in concert with the magnetic and optical variations during periods of broadband pulsation activity, but no riometer variations are noted during periods of narrow-band activity. Because riometers are sensitive to electrons of auroral energies (several keV and above), while the 427.8-nm photometer is sensitive to precipitation with much lower energies, they interpret these observatons as showing that precipitating magnetosheathlike electrons (with energies {le} 1 keV) at nominal dayside cleft latitudes are at times modulated with frequencies similar to those of upstream waves. They suggest that these particles may play an important role, via modification of ionospheric currents and conductivities, in the transmission of upstream wave signals into the magnetosphere and in the generation of dayside high-latitude Pc 3 pulsations.

  14. FLUID- THERMODYNAMIC AND TRANSPORT PROPERTIES OF FLUIDS (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Fessler, T. E.

    1994-01-01

    The accurate computation of the thermodynamic and transport properties of fluids is a necessity for many engineering calculations. The FLUID program was developed to calculate the thermodynamic and transport properties of pure fluids in both the liquid and gas phases. Fluid properties are calculated using a simple gas model, empirical corrections, and an efficient numerical interpolation scheme. FLUID produces results that are in very good agreement with measured values, while being much faster than older more complex programs developed for the same purpose. A Van der Waals equation of state model is used to obtain approximate state values. These values are corrected for real-gas effects by model correction factors obtained from tables based on experimental data. These tables also accurately compensate for the special circumstances which arise whenever phase conditions occur. Viscosity and thermal conductivity values are computed directly from tables. Interpolation within tables is based on Lagrange's three point formula. A set of tables must be generated for each fluid implemented. FLUID currently contains tables for nine fluids including dry air and steam. The user can add tables for any fluid for which adequate thermal property data is available. The FLUID routine is structured so that it may easily be incorporated into engineering programs. The IBM 360 version of FLUID was developed in 1977. It is written in FORTRAN IV and has been implemented on an IBM 360 with a central memory requirement of approximately 222K of 8 bit bytes. The IBM PC version of FLUID is written in Microsoft FORTRAN 77 and has been implemented on an IBM PC with a memory requirement of 128K of 8 bit bytes. The IBM PC version of FLUID was developed in 1986.

  15. A PC-controlled voltage pulse generator for electroanalytical applications

    NASA Astrophysics Data System (ADS)

    Heredia-López, Francisco J.; Góngora-Alfaro, José L.; Alvarez-Cervera, Fernando J.; Bata-García, José Luis

    1997-04-01

    We present the design of a voltage pulse generator controlled by an IBM or compatible AT Personal Computer (PC) capable of synthesizing some of the voltage pulse wave forms commonly used in electrochemical studies. The included signals are: differential pulse voltametry, differential normal pulse voltametry, and differential pulse amperometry. Additionally, a triangular wave form and a constant-voltage signal, used in the pretreatment of carbon fiber microelectrodes for neurochemical analysis, are also available. Operating the generator imposes a minimum of restrictions on the specification of the duration, amplitude, and type of wave shapes. Low-cost PC-based design allows for compatibility, portability, and versatility. The operating ranges of the wave form parameters for the three voltametric signals are: initial voltage, -0.9-+0.9 V; step amplitude, 0.1-900 mV; period, 6 ms-60 s; measuring pulse amplitude, 0.1-900 mV; measuring pulse duration, 2 ms-20 s; prepulse duration, 2 ms-20 s. In the electrode pretreatment mode, the operating ranges are: amplitude, 0-±5 V; duration, unlimited; frequency, 15-240 Hz. The generator uses its own time base for the generation of all signals, thereby rendering it independent of processor clock speed or power-line frequency. The results of the experimental evaluation indicate that the system is accurate within ±10% of the expected values, taking into account the errors associated with the signal synthesis and the digitizing process. The maximum achievable scan rate is 500 V/s, and the highest frequency for the triangular wave form is 240 Hz. Therefore, the pulse generator could be used for fast cyclic voltametry (FCV). FCV and other wave forms could be added through software modules, without any hardware changes. We conclude that the PC-based electrochemistry pulse generator represents an economical and flexible alternative for electroanalytical applications.

  16. CWG - MUTUAL COUPLING PROGRAM FOR CIRCULAR WAVEGUIDE-FED APERTURE ARRAY (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Bailey, M. C.

    1994-01-01

    aperture combinations. The scattering matrix can then be used to determine the complex modal field amplitudes for each aperture with a specified array excitation. CWG is written in VAX FORTRAN for DEC VAX series computers running VMS (LAR-15236) and IBM PC series and compatible computers running MS-DOS (LAR-15226). It requires 360K of RAM for execution. To compile the source code for the PC version, the NDP Fortran compiler and linker will be required; however, the distribution medium for the PC version of CWG includes a sample MS-DOS executable which was created using NDP Fortran with the -vms compiler option. The standard distribution medium for the PC version of CWG is a 3.5 inch 1.44Mb MS-DOS format diskette. The standard distribution medium for the VAX version of CWG is a 1600 BPI 9track magnetic tape in DEC VAX BACKUP format. The VAX version is also available on a TK50 tape cartridge in DEC VAX BACKUP format. Both machine versions of CWG include an electronic version of the documentation in Microsoft Word for Windows format. CWG was developed in 1993 and is a copyrighted work with all copyright vested in NASA.

  17. Track Initiation for Electro-Optical Tracking of Space Objects

    NASA Astrophysics Data System (ADS)

    Xu, Z. W.; Wang, X.

    2016-03-01

    Aimed at the track initiation for the electro-optical tracking of space objects, and based on modified Hough transformation, a track initiation algorithm without prior information is proposed to realize the fully robotic identification and tracking of moving objects. The method is valid for the tracking of multi-target as well as with a non-continuous sequence. Simulation shows that the method is effective and applicable for operational usage, and is especially good for the search and discovery of new objects.

  18. Satellite (IRLS) tracking of elk

    NASA Technical Reports Server (NTRS)

    Buechner, H. K.

    1972-01-01

    The practicability of tracking free roaming animals in natural environments by satellite systems is reported. Satellite systems combine continuous tracking with simultaneous monitoring of physiological and environmental parameters through a combination of radio tracking and biotelemetric ground systems that lead to a better understanding of animal behavior and migration patterns.

  19. The Mystery of Animal Tracking

    ERIC Educational Resources Information Center

    Communicator, 1975

    1975-01-01

    A simple animal track guide is given to help students and teachers recognize some of the common animal tracks found in many parts of the country. The tracks are divided into 3 basic categories: 1) flatfoots, 2) toe-walkers, and 3) toe-nail walkers. (NQ)

  20. METHANE DE-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2001-10-30

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NO{sub x} emissions to 0.15 lb/million Btu or less without post-combustion flue gas cleaning. Work during the quarter included completion of the equipment fabrication and installation efforts for the 3-million Btu/h pilot system at BBP's Pilot-Scale Combustion Facility (PSCF) in Worcester, MA. Final selection of the first two test coals and preliminary selection of the final two test coals were also completed.

  1. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser

    2001-01-30

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NOx emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NOx reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to make this technology ready for full-scale commercial deployment by 2002-2003 in order to meet an anticipated market demand for NOx reduction technologies resulting from the EPA's NOx SIP call.

  2. PC analysis of an acousto-ultrasonic signal

    NASA Technical Reports Server (NTRS)

    Kiernan, M. T.; Duke, J. C., Jr.

    1988-01-01

    An introduction is given to PC software developed to analyze a digitized signal. The specific way in which the software was implemented and the relative ease with which the same software can be implemented in different systems for various applications are discussed. The basic equations and related theory used in the software are furnished. Specifically, mention is made of signal digitization, dc biasing, Fourier analysis, moment analysis, digital filtering, and transfer functions. Examples of calculations are given to indicate the physical significance of variables calculated from the frequency domain via moment equations.

  3. A PC-based titrator for flow gradient titrations

    PubMed Central

    Fuhrmann, B.

    1993-01-01

    This paper describes a PC (personal computer) based titrator which was developed for gradient flow titrations. Concentration gradients were generated electrolytically or volumetrically in small tubes. Complete titration curves can be recorded on-line and evaluated automatically. The titrator can be used with all liquid flow detectors with low axial dispersion. The titrator was evaluated for the titration of thiosulphate with electrogenerated triiodide and for the titration of ammonia with electrogenerated hypobromite after continuous gas dialytic separation of ammonia from the sample solution. PMID:18924977

  4. On particle track detectors

    NASA Technical Reports Server (NTRS)

    Benton, E. V.; Gruhn, T. A.; Andrus, C. H.

    1973-01-01

    Aqueous sodium hydroxide is widely used to develop charged particle tracks in polycarbonate film, particularly Lexan. The chemical nature of the etching process for this system has been determined. A method employing ultra-violet absorbance was developed for monitoring the concentration of the etch products in solution. Using this method it was possible to study the formation of the etching solution saturated in etch products. It was found that the system super-saturates to a significant extent before precipitation occurs. It was also learned that the system approaches its equilibrium state rather slowly. It is felt that both these phenomena may be due to the presence of surfactant in the solution. In light of these findings, suggestions are given regarding the preparation and maintenance of the saturated etch solution. Two additional research projects, involving automated techniques for particle track analysis and particle identification using AgCl crystals, are briefly summarized.

  5. Tracking change over time

    USGS Publications Warehouse

    ,

    2011-01-01

    Landsat satellites capture images of Earth from space-and have since 1972! These images provide a long-term record of natural and human-induced changes on the global landscape. Comparing images from multiple years reveals slow and subtle changes as well as rapid and devastating ones. Landsat images are available over the Internet at no charge. Using the free software MultiSpec, students can track changes to the landscape over time-just like remote sensing scientists do! The objective of the Tracking Change Over Time lesson plan is to get students excited about studying the changing Earth. Intended for students in grades 5-8, the lesson plan is flexible and may be used as a student self-guided tutorial or as a teacher-led class lesson. Enhance students' learning of geography, map reading, earth science, and problem solving by seeing landscape changes from space.

  6. Longwall shearer tracking system

    NASA Technical Reports Server (NTRS)

    Poulsen, P. D. (Inventor); Stein, R. J.; Pease, R. E.

    1984-01-01

    A tracking system for measuring and recording the movements of a longwall shearer vehicle includes an optical tracking assembly carried at one end of a desired vehicle path and a retroreflector assembly carried by the vehicle. Continuous horizontal and vertical light beams are alternately transmitted by means of a rotating Dove prism to the reflector assembly. A vertically reciprocating reflector interrupts the continuous light beams and converts these to discrete horizontal and vertical light beam images transmitted at spaced intervals along the path. A second rotating Dove prism rotates the vertical images to convert them to a second series of horizontal images while the first mentioned horizontal images are left unrotated and horizontal. The images are recorded on a film.

  7. Fast track evaluation methodology.

    PubMed

    Duke, J R

    1991-06-01

    Evaluating hospital information systems has taken a variety of forms since the initial development and use of automation. The process itself has moved from a hardware-based orientation controlled by data processing professionals to systems solutions and a user-driven process overseen by management. At Harbor Hospital Center in Baltimore, a fast track methodology has been introduced to shorten system evaluation time to meet the rapid changes that constantly affect the healthcare industry.

  8. PARTICLE BEAM TRACKING CIRCUIT

    DOEpatents

    Anderson, O.A.

    1959-05-01

    >A particle-beam tracking and correcting circuit is described. Beam induction electrodes are placed on either side of the beam, and potentials induced by the beam are compared in a voltage comparator or discriminator. This comparison produces an error signal which modifies the fm curve at the voltage applied to the drift tube, thereby returning the orbit to the preferred position. The arrangement serves also to synchronize accelerating frequency and magnetic field growth. (T.R.H.)

  9. EPAct Transportation Regulatory Activities

    SciTech Connect

    2011-11-21

    The U.S. Department of Energy's (DOE) Vehicle Technologies Program manages several transportation regulatory activities established by the Energy Policy Act of 1992 (EPAct), as amended by the Energy Conservation Reauthorization Act of 1998, EPAct 2005, and the Energy Independence and Security Act of 2007 (EISA).

  10. The regulatory horizon

    NASA Technical Reports Server (NTRS)

    Cook, ED

    1987-01-01

    The author briefly discusses the FAA's position as it relates to cockpit resource management. For example, if Cockpit Resource Management (CRM) is a positive concept, why isn't everyone required to implement it? The regulatory practice of the FAA is discussed and questions and answers are presented.

  11. Eye-Tracking Data

    PubMed Central

    Galesic, Mirta; Tourangeau, Roger; Couper, Mick P.; Conrad, Frederick G.

    2008-01-01

    Survey researchers since Cannell have worried that respondents may take various shortcuts to reduce the effort needed to complete a survey. The evidence for such shortcuts is often indirect. For instance, preferences for earlier versus later response options have been interpreted as evidence that respondents do not read beyond the first few options. This is really only a hypothesis, however, that is not supported by direct evidence regarding the allocation of respondent attention. In the current study, we used a new method to more directly observe what respondents do and do not look at by recording their eye movements while they answered questions in a Web survey. The eye-tracking data indicate that respondents do in fact spend more time looking at the first few options in a list of response options than those at the end of the list; this helps explain their tendency to select the options presented first regardless of their content. In addition, the eye-tracking data reveal that respondents are reluctant to invest effort in reading definitions of survey concepts that are only a mouse click away or paying attention to initially hidden response options. It is clear from the eye-tracking data that some respondents are more prone to these and other cognitive shortcuts than others, providing relatively direct evidence for what had been suspected based on more conventional measures. PMID:21253437

  12. Fast Track Study

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Fast Track Study supports the efforts of a Special Study Group (SSG) made up of members of the Advanced Project Management Class number 23 (APM-23) that met at the Wallops Island Management Education Center from April 28 - May 8, 1996. Members of the Class expressed interest to Mr. Vem Weyers in having an input to the NASA Policy Document (NPD) 7120.4, that will replace NASA Management Institute (NMI) 7120.4, and the NASA Program/Project Management Guide. The APM-23 SSG was tasked with assisting in development of NASA policy on managing Fast Track Projects, defined as small projects under $150 million and completed within three years. 'Me approach of the APM-23 SSG was to gather data on successful projects working in a 'Better, Faster, Cheaper' environment, within and outside of NASA and develop the Fast Track Project section of the NASA Program/Project Management Guide. Fourteen interviews and four other data gathering efforts were conducted by the SSG, and 16 were conducted by Strategic Resources, Inc. (SRI), including five interviews at the Jet Propulsion Laboratory (JPL) and one at the Applied Physics Laboratory (APL). The interviews were compiled and analyzed for techniques and approaches commonly used to meet severe cost and schedule constraints.

  13. Approximate Bayesian multibody tracking.

    PubMed

    Lanz, Oswald

    2006-09-01

    Visual tracking of multiple targets is a challenging problem, especially when efficiency is an issue. Occlusions, if not properly handled, are a major source of failure. Solutions supporting principled occlusion reasoning have been proposed but are yet unpractical for online applications. This paper presents a new solution which effectively manages the trade-off between reliable modeling and computational efficiency. The Hybrid Joint-Separable (HJS) filter is derived from a joint Bayesian formulation of the problem, and shown to be efficient while optimal in terms of compact belief representation. Computational efficiency is achieved by employing a Markov random field approximation to joint dynamics and an incremental algorithm for posterior update with an appearance likelihood that implements a physically-based model of the occlusion process. A particle filter implementation is proposed which achieves accurate tracking during partial occlusions, while in cases of complete occlusion, tracking hypotheses are bound to estimated occlusion volumes. Experiments show that the proposed algorithm is efficient, robust, and able to resolve long-term occlusions between targets with identical appearance. PMID:16929730

  14. Energy Tracking Diagrams

    NASA Astrophysics Data System (ADS)

    Scherr, Rachel E.; Harrer, Benedikt W.; Close, Hunter G.; Daane, Abigail R.; DeWater, Lezlie S.; Robertson, Amy D.; Seeley, Lane; Vokos, Stamatis

    2016-02-01

    Energy is a crosscutting concept in science and features prominently in national science education documents. In the Next Generation Science Standards, the primary conceptual learning goal is for learners to conserve energy as they track the transfers and transformations of energy within, into, or out of the system of interest in complex physical processes. As part of tracking energy transfers among objects, learners should (i) distinguish energy from matter, including recognizing that energy flow does not uniformly align with the movement of matter, and should (ii) identify specific mechanisms by which energy is transferred among objects, such as mechanical work and thermal conduction. As part of tracking energy transformations within objects, learners should (iii) associate specific forms with specific models and indicators (e.g., kinetic energy with speed and/or coordinated motion of molecules, thermal energy with random molecular motion and/or temperature) and (iv) identify specific mechanisms by which energy is converted from one form to another, such as incandescence and metabolism. Eventually, we may hope for learners to be able to optimize systems to maximize some energy transfers and transformations and minimize others, subject to constraints based in both imputed mechanism (e.g., objects must have motion energy in order for gravitational energy to change) and the second law of thermodynamics (e.g., heating is irreversible). We hypothesize that a subsequent goal of energy learning—innovating to meet socially relevant needs—depends crucially on the extent to which these goals have been met.

  15. Respiration tracking in radiosurgery

    SciTech Connect

    Schweikard, Achim; Shiomi, Hiroya; Adler, John

    2004-10-01

    Respiratory motion is difficult to compensate for with conventional radiotherapy systems. An accurate tracking method for following the motion of the tumor is of considerable clinical relevance. We investigate methods to compensate for respiratory motion using robotic radiosurgery. In this system the therapeutic beam is moved by a robotic arm, and follows the moving target through a combination of infrared tracking and synchronized x-ray imaging. Infrared emitters are used to record the motion of the patient's skin surface. The position of internal gold fiducials is computed repeatedly during treatment, via x-ray image processing. We correlate the motion between external and internal markers. From this correlation model we infer the placement of the internal target during time intervals where no x-ray images are taken. Fifteen patients with lung tumors have recently been treated with a fully integrated system implementing this new method. The clinical trials confirm our hypothesis that internal motion and external motion are indeed correlated. In a preliminar study we have extended our work to tracking without implanted fiducials, based on algorithms for computing deformation motions and digitally reconstructed radiographs.

  16. TRACKING CLEAN UP AT HANFORD

    SciTech Connect

    CONNELL, C.W.

    2005-05-27

    The Hanford Federal Facility Agreement and Consent Order, known as the ''Tri-Party Agreement'' (TPA), is a legally binding agreement among the US Department of Energy (DOE), The Washington State Department of Ecology, and the US Environmental Protection Agency (EPA) for cleaning up the Hanford Site. Established in the 1940s to produce material for nuclear weapons as part of the Manhattan Project, Hanford is often referred to as the world's large environmental cleanup project. The Site covers more than 580 square miles in a relatively remote region of southeastern Washington state in the US. The production of nuclear materials at Hanford has left a legacy of tremendous proportions in terms of hazardous and radioactive waste. From a waste-management point of view, the task is enormous: 1700 waste sites; 450 billion gallons of liquid waste; 70 billion gallons of contaminated groundwater; 53 million gallons of tank waste; 9 reactors; 5 million cubic yards of contaminated soil; 22 thousand drums of mixed waste; 2.3 tons of spent nuclear fuel; and 17.8 metric tons of plutonium-bearing material and this is just a partial listing. The agreement requires that DOE provide the results of analytical laboratory and non-laboratory tests/readings to the lead regulatory agency to help guide then in making decisions. The agreement also calls for each signatory to preserve--for at least ten years after the Agreement has ended--all of the records in it, or its contractors, possession related to sampling, analysis, investigations, and monitoring conducted. The Action Plan that supports the TPA requires that Ecology and EPA have access to all data that is relevant to work performed, or to be performed, under the Agreement. Further, the Action Plan specifies two additional requirements: (1) that EPA, Ecology and their respective contractor staffs have access to all the information electronically, and (2) that the databases are accessible to, and used by, all personnel doing TPA

  17. Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

    PubMed Central

    Wang, Wei; Qin, Jiang-Jiang; Voruganti, Sukesh; Nag, Subhasree; Zhou, Jianwei; Zhang, Ruiwen

    2016-01-01

    Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More recently, they have been found to play important roles in human carcinogenesis and cancer development and progression. The deregulation and dysfunction of PcG proteins often lead to blocking or inappropriate activation of developmental pathways, enhancing cellular proliferation, inhibiting apoptosis, and increasing the cancer stem cell population. Genetic and molecular investigations of PcG proteins have long been focused on their PcG functions. However, PcG proteins have recently been shown to exert non-polycomb functions, contributing to the regulation of diverse cellular functions. We and others have demonstrated that PcG proteins regulate the expression and function of several oncogenes and tumor suppressor genes in a PcG-independent manner, and PcG proteins are associated with the survival of patients with cancer. In this review, we summarize the recent advances in the research on PcG proteins, including both the polycomb-repressive and non-polycomb functions. We specifically focus on the mechanisms by which PcG proteins play roles in cancer initiation, development, and progression. Finally, we discuss the potential value of PcG proteins as molecular biomarkers for the diagnosis and prognosis of cancer, and as molecular targets for cancer therapy. PMID:26227500

  18. Transcriptional Coactivator and Chromatin Protein PC4 Is Involved in Hippocampal Neurogenesis and Spatial Memory Extinction.

    PubMed

    Swaminathan, Amrutha; Delage, Hélène; Chatterjee, Snehajyoti; Belgarbi-Dutron, Laurence; Cassel, Raphaelle; Martinez, Nicole; Cosquer, Brigitte; Kumari, Sujata; Mongelard, Fabien; Lannes, Béatrice; Cassel, Jean-Christophe; Boutillier, Anne-Laurence; Bouvet, Philippe; Kundu, Tapas K

    2016-09-23

    Although the elaborate combination of histone and non-histone protein complexes defines chromatin organization and hence regulates numerous nuclear processes, the role of chromatin organizing proteins remains unexplored at the organismal level. The highly abundant, multifunctional, chromatin-associated protein and transcriptional coactivator positive coactivator 4 (PC4/Sub1) is absolutely critical for life, because its absence leads to embryonic lethality. Here, we report results obtained with conditional PC4 knock-out (PC4(f/f) Nestin-Cre) mice where PC4 is knocked out specifically in the brain. Compared with the control (PC4(+/+) Nestin-Cre) mice, PC4(f/f) Nestin-Cre mice are smaller with decreased nocturnal activity but are fertile and show no motor dysfunction. Neurons in different areas of the brains of these mice show sensitivity to hypoxia/anoxia, and decreased adult neurogenesis was observed in the dentate gyrus. Interestingly, PC4(f/f) Nestin-Cre mice exhibit a severe deficit in spatial memory extinction, whereas acquisition and long term retention were unaffected. Gene expression analysis of the dorsal hippocampus of PC4(f/f) Nestin-Cre mice revealed dysregulated expression of several neural function-associated genes, and PC4 was consistently found to localize on the promoters of these genes, indicating that PC4 regulates their expression. These observations indicate that non-histone chromatin-associated proteins like PC4 play a significant role in neuronal plasticity.

  19. Fuzzy Logic Particle Tracking

    NASA Technical Reports Server (NTRS)

    2005-01-01

    A new all-electronic Particle Image Velocimetry technique that can efficiently map high speed gas flows has been developed in-house at the NASA Lewis Research Center. Particle Image Velocimetry is an optical technique for measuring the instantaneous two component velocity field across a planar region of a seeded flow field. A pulsed laser light sheet is used to illuminate the seed particles entrained in the flow field at two instances in time. One or more charged coupled device (CCD) cameras can be used to record the instantaneous positions of particles. Using the time between light sheet pulses and determining either the individual particle displacements or the average displacement of particles over a small subregion of the recorded image enables the calculation of the fluid velocity. Fuzzy logic minimizes the required operator intervention in identifying particles and computing velocity. Using two cameras that have the same view of the illumination plane yields two single exposure image frames. Two competing techniques that yield unambiguous velocity vector direction information have been widely used for reducing the single-exposure, multiple image frame data: (1) cross-correlation and (2) particle tracking. Correlation techniques yield averaged velocity estimates over subregions of the flow, whereas particle tracking techniques give individual particle velocity estimates. For the correlation technique, the correlation peak corresponding to the average displacement of particles across the subregion must be identified. Noise on the images and particle dropout result in misidentification of the true correlation peak. The subsequent velocity vector maps contain spurious vectors where the displacement peaks have been improperly identified. Typically these spurious vectors are replaced by a weighted average of the neighboring vectors, thereby decreasing the independence of the measurements. In this work, fuzzy logic techniques are used to determine the true

  20. The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2.

    PubMed Central

    Martens, G J; Braks, J A; Eib, D W; Zhou, Y; Lindberg, I

    1994-01-01

    The subtilisin-like prohormone convertase PC2 and the polypeptide 7B2 (an intracellularly cleaved protein of unknown function) are both selectively present in the regulated secretory pathway of neurons and endocrine cells. Here we demonstrate that intact recombinant 7B2 is a potent inhibitor of PC2 and prevents proPC2 cleavage in vitro, whereas the 7B2 cleavage product is virtually inactive. The PC2-related proteinase PC1/PC3 is not inhibited by 7B2. Furthermore, the carboxyl-terminal half of the 7B2 protein sequence is distantly related to the so-called potato inhibitor I family (which includes subtilisin inhibitors). Our findings indicate that 7B2 is a physiological inhibitor of PC2 and may provide alternative avenues for the manipulation of peptide hormone levels. Images PMID:8016065

  1. Dielectric and Energy Storage Properties of the Heterogeneous P(VDF-HFP)/PC Composite Films

    NASA Astrophysics Data System (ADS)

    Zhao, Xiaojia; Peng, Guirong; Zhan, Zaiji

    2016-09-01

    Polymer-based materials with a high discharge energy and low energy loss have attracted considerable attention for energy storage applications. A new class of polymer-based composite films composed of amorphous polycarbonate (PC) and poly(vinylidene fluoride-hexafluoropropylene) [P(VDF-HFP)] has been fabricated by simply solution blending followed by thermal treatment under vacuum. The results show that the diameter of the spherical phase for PC and the melting temperature of P(VDF-HFP) increase, and the crystallinity and crystallization temperature of P(VDF-HFP) decrease with increasing PC content. The phase transition from the polar β phase to weak polarity γ phase is induced by PC addition. Moreover, the Curie temperature of the P(VDF-HFP)/PC composite films shifts to a lower temperature. With the addition of PC, the permittivity, polarization and discharge energy of the P(VDF-HFP)/PC composite films slightly decrease. However, the energy loss is significantly reduced.

  2. Human transcriptional coactivator PC4 stimulates DNA end joining and activates DSB repair activity.

    PubMed

    Batta, Kiran; Yokokawa, Masatoshi; Takeyasu, Kunio; Kundu, Tapas K

    2009-01-23

    Human transcriptional coactivator PC4 is a highly abundant nuclear protein that is involved in diverse cellular processes ranging from transcription to chromatin organization. Earlier, we have shown that PC4, a positive activator of p53, overexpresses upon genotoxic insult in a p53-dependent manner. In the present study, we show that PC4 stimulates ligase-mediated DNA end joining irrespective of the source of DNA ligase. Pull-down assays reveal that PC4 helps in the association of DNA ends through its C-terminal domain. In vitro nonhomologous end-joining assays with cell-free extracts show that PC4 enhances the joining of noncomplementary DNA ends. Interestingly, we found that PC4 activates double-strand break (DSB) repair activity through stimulation of DSB rejoining in vivo. Together, these findings demonstrate PC4 as an activator of nonhomologous end joining and DSB repair activity.

  3. Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells.

    PubMed

    Czyzyk-Krzeska, M F; Furnari, B A; Lawson, E E; Millhorn, D E

    1994-01-01

    Reduced arterial oxygen tension (i.e. hypoxia) is a powerful physiological stimulus that induces synthesis and release of dopamine from O2-sensitive (type I) cells in the mammalian carotid bodies. We reported recently that hypoxia stimulates gene expression for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis in type I cells of the carotid body. Efforts to identify the mechanisms regulating TH gene expression in O2-sensitive cells during hypoxia have been hampered by the lack of an appropriate model cell culture system. Here we report that TH gene expression in the rat pheochromocytoma cell line (PC12) is regulated during hypoxia in a manner similar to that measured in carotid body type I cells. PC12 cells might therefore be useful as an experimental model for identifying the molecular mechanisms that regulate TH gene expression during hypoxia. Nuclear runoff assays revealed that transcription of the wild type TH gene was enhanced during exposures to hypoxia lasting 12 h. Chloramphenicol acetyltransferase assays with constructs that contained different fragments of TH promoter revealed that the regulatory sequences that mediate the hypoxia-induced increase in transcription are located between bases -272 and +27 of the TH gene. Findings from experiments in which transcription was inhibited either with actinomycin D or 5,6-dichloro-1-D-ribofuranosylbenzimidazole, as well as pulse-chase experiments using 4-thiouridine showed that the half-life of TH mRNA was substantially increased during hypoxia. Thus, in the present paper we show that TH gene expression in PC12 cells during hypoxia is regulated by increases in both the rate of TH gene transcription and TH mRNA stability. PMID:7903970

  4. A DMC study on FePc electronic state

    NASA Astrophysics Data System (ADS)

    Ichibha, Tom; Hongo, Kenta; Maezono, Ryo

    We performed fixed-node DMC calculations on an isolated FePc [Iron(II) Phthalocyanine] using CASSCF nodal surfaces, getting its ground state, 3A2 g [dz22dxz, yz 2dxy2 ]. Virial ratios for each state are achieved to be within 0.042% around 2.0. Recent studies are proposing a mixed state with 3Eg (b) and 3B2 g as the ground state, while past ab-initio calculations are predicting 3A2 g or 3Eg (a) , giving still controversial arguments even within isolated/no-LS coupling model. Under D4 h ligand field parameter space, (10Dq , Dt, Ds), the state, 3A2 g , is reported to be possible as a ground state, while it is not when we restrict the space into 2-dim sub-space corresponding to more specified symmetry as in FePc with plane square alignment of neighboring N to Fe ('superposition model'). Our optimized geometry also satisfies the same symmetry, and hence appears to be contradicting to the ligand theory.

  5. CAP88-PC Version 4, an updated radionuclide NESHAPS model.

    PubMed

    Wood, Raymond; Stuenkel, David; Rosnick, Reid

    2013-08-01

    The latest version of the CAP88-PC computer model, Version 4, has many changes and improvements from previous versions. The most significant of these changes from a user perspective are the incorporation of age-dependent radionuclide dose and risk factors for ingestion and inhalation, the increase in the number of included radionuclides, and a change in the file management system used by the program. Other changes less visible to the user include new code architecture, incorporation of numerical solvers for the calculation of radioactive decay chains, including the ingrowth of decay products during air transport and ground surface deposition, enhanced error messages, updated on-line help, and a utility for migrating Version 3 datasets, wind files, and population files to Version 4. The modifications have produced a significant improvement in speed and stability for Version 4 relative to Version 3 and eliminated the solution approximations used in Version 3. The U.S. Environmental Protection Agency has implemented an extensive testing and documentation program for CAP88-PC Version 4 to address user concerns with past versions, resulting in enhanced documentation supporting compatibility with user software quality assurance programs. PMID:23803671

  6. The white dwarf population within 40 pc of the Sun

    NASA Astrophysics Data System (ADS)

    Torres, Santiago; García-Berro, Enrique

    2016-04-01

    Context. The white dwarf luminosity function is an important tool to understand the properties of the solar neighborhood, like its star formation history, and its age. Aims: Here we present a population synthesis study of the white dwarf population within 40 pc from the Sun, and compare the results of this study with the properties of the observed sample. Methods: We use a state-of-the-art population synthesis code based on Monte Carlo techniques, which incorporates the most recent and reliable white dwarf cooling sequences, an accurate description of the Galactic neighborhood, and a realistic treatment of all the known observational biases and selection procedures. Results: We find a good agreement between our theoretical models and the observed data. In particular, our simulations reproduce a previously unexplained feature of the bright branch of the white dwarf luminosity function, which we argue is due to a recent episode of star formation. We also derive the age of the solar neighborhood employing the position of the observed cut-off of the white dwarf luminosity function, to obtain ~8.9 ± 0.2 Gyr. Conclusions: We conclude that a detailed description of the ensemble properties of the population of white dwarfs within 40 pc of the Sun allows us to obtain interesting constraints on the history of the Solar neighborhood.

  7. CAP88-PC Version 4, an updated radionuclide NESHAPS model.

    PubMed

    Wood, Raymond; Stuenkel, David; Rosnick, Reid

    2013-08-01

    The latest version of the CAP88-PC computer model, Version 4, has many changes and improvements from previous versions. The most significant of these changes from a user perspective are the incorporation of age-dependent radionuclide dose and risk factors for ingestion and inhalation, the increase in the number of included radionuclides, and a change in the file management system used by the program. Other changes less visible to the user include new code architecture, incorporation of numerical solvers for the calculation of radioactive decay chains, including the ingrowth of decay products during air transport and ground surface deposition, enhanced error messages, updated on-line help, and a utility for migrating Version 3 datasets, wind files, and population files to Version 4. The modifications have produced a significant improvement in speed and stability for Version 4 relative to Version 3 and eliminated the solution approximations used in Version 3. The U.S. Environmental Protection Agency has implemented an extensive testing and documentation program for CAP88-PC Version 4 to address user concerns with past versions, resulting in enhanced documentation supporting compatibility with user software quality assurance programs.

  8. PC-SEAPAK user's guide, version 4.0

    NASA Technical Reports Server (NTRS)

    Mcclain, Charles R.; Fu, Gary; Darzi, Michael; Firestone, James K.

    1992-01-01

    PC-SEAPAK is designed to provide a complete and affordable capability for processing and analysis of NOAA Advanced Very High Resolution Radiometer (AVHRR) and Nimbus-7 Coastal Zone Color Scanner (CZCS) data. Since the release of version 3.0 over a year ago, significant revisions were made to the AVHRR and CZCS programs and to the statistical data analysis module, and a number of new programs were added. This new version has 114 procedures listed in its menus. The package continues to emphasize user-friendliness and interactive data analysis. Additionally, because the scientific goals of the ocean color research being conducted have shifted to larger space and time scales, batch processing capabilities were enhanced, allowing large quantities of data to be easily ingested and analyzed. The development of PC-SEAPAK was paralled by two other activities that were influential and assistive: the global CZCS processing effort at GSFC and the continued development of VAX-SEAPAK. SEAPAK incorporates the instrument calibration and support all levels of data available from the CZCS archive.

  9. High-level PC-based laser system modeling

    NASA Astrophysics Data System (ADS)

    Taylor, Michael S.

    1991-05-01

    Since the inception of the Strategic Defense Initiative (SDI) there have been a multitude of comparison studies done in an attempt to evaluate the effectiveness and relative sizes of complementary, and sometimes competitive, laser weapon systems. It became more and more apparent that what the systems analyst needed was not only a fast, but a cost effective way to perform high-level trade studies. In the present investigation, a general procedure is presented for the development of PC-based algorithmic systems models for laser systems. This procedure points out all of the major issues that should be addressed in the design and development of such a model. Issues addressed include defining the problem to be modeled, defining a strategy for development, and finally, effective use of the model once developed. Being a general procedure, it will allow a systems analyst to develop a model to meet specific needs. To illustrate this method of model development, a description of the Strategic Defense Simulation - Design To (SDS-DT) model developed and used by Science Applications International Corporation (SAIC) is presented. SDS-DT is a menu-driven, fast executing, PC-based program that can be used to either calculate performance, weight, volume, and cost values for a particular design or, alternatively, to run parametrics on particular system parameters to perhaps optimize a design.

  10. PC-based closed-circuit television system

    NASA Astrophysics Data System (ADS)

    Christoffersen, Daniel; Clark, Carl

    The PC-based closed-circuit television (CCTV) system is a low-cost, highly functional alternative to conventional video system equipment. The system provides routing switching, character generation, video presence detection, and solid-state video recording and replay by using four uniquely designed boards that fit into the backplane slots of an IBM PC-XT-compatible personal computer. Each board controls 16 separate channels, and the boards can be daisy-chained together to build larger, more powerful systems. The system can be configured to handle as many as 240 input signals or up to 48 output channels, and uses a redundant video bus loop. The video bus can be tapped into throughout the loop to provide localized routing switching within several buildings, and video termination at multiple locations, such as security operators' stations. This approach reduces cabling costs and allows additional routing switchers to be added easily with little impact on existing equipment. The system is capable of communicating with several control interfaces, and control software is currently in place for communicating via an RS-232 link and the Intel BitBus network. The hardware drivers are Microsoft C modules that can be linked with a user developed control program.

  11. Paleomap PC: Plate tectonic reconstructions on IBM compatible computers

    SciTech Connect

    Walsh, D.B.; Scotese, C.R. . Dept. Geology)

    1993-02-01

    PALEOMAP-PC (PMAPPC) allows users to interactively view Phanerozoic plate reconstructions on IBM compatible personal computers. This software compliments Macintosh and Unix software developed to conjunction with the PALEOMAP Project at the University of Texas at Arlington. The past positions of the continents can be viewed on the PC monitor in a variety of map projections including the spherical projection which gives a 3-D perspective of the Earth. Once a reconstruction time has been entered, the total finite rotations for over 150 independently moving plates are calculated and the plates are rotated back through time and drawn in reconstructed coordinates. The user can zoom in and out focusing on particular areas of interest. Hard copy output is available to a variety of output devices, both as a screen dump utility and as a selected option within the program. Although visualizing continental configurations through time is the core of the program, its primary strength is that user-defined data, such as stratigraphic or structural data, can be incorporated and plotted on reconstructed basemaps. This allows the time aspect of all geological data to be united with other user-supplied data within the plate tectonic framework.

  12. Regulation of CREB by moderate hypoxia in PC12 cells.

    PubMed

    Beitner-Johnson, D; Rust, R T; Hsieh, T; Millhorn, D E

    2000-01-01

    The mechanisms by which excitable cells adapt and respond to changes in O2 levels remain largely unknown. We have investigated the effect of hypoxia on the cyclic AMP response element binding protein (CREB) transcription factor. PC12 cells were exposed to moderate levels of hypoxia (5% O2) for various times between 20 min and 6 hr. We found that hypoxia rapidly and persistently induced ser133 phosphorylation of CREB. This effect was more robust than that produced by exposing PC12 cells to either forskolin, KCl, or NGF. This effect was not due to activation of any of the previously known CREB kinases, including PKA, CaMK, PKC, p70s6k, or MAPKAP kinase-2. Thus, hypoxia may induce activation of a novel CREB kinase. To test whether phosphorylation of CREB was associated with an activation of CRE-dependent gene expression, cells were transfected with wild type and mutated regions of the 5'-flanking region of the tyrosine hydroxylase (TH) gene fused to a CAT reporter gene. Mutation of the CRE element in a TH reporter gene reduced, but did not abolish, the effects of hypoxia on TH gene expression. However, hypoxia did not induce transactivation of a GAL4-luciferase reporter by a GAL4-CREB fusion protein. Thus, the mechanism by which hypoxia regulates CREB is distinct, and more complex, than that induced by forskolin, depolarization, or nerve growth factor. PMID:10849656

  13. Commodity clusters: Performance comparison between PC`s and workstations

    SciTech Connect

    Carter, R.; Laroco, J.; Armstrong, R.

    1996-03-01

    Workstation clusters were originally developed as a way to leverage the better cost basis of UNIX workstations to perform computations previously handled only by relatively more expensive supercomputers. Commodity workstation clusters take this evolutionary process one step further by replacing equivalent proprietary workstation functionality with less expensive PC technology. As PC technology encroaches on proprietary UNIX workstation vendor markets, these vendors will see a declining share of the overall market. As technology advances continue, the ability to upgrade a workstations performance plays a large role in cost analysis. For example, a major upgrade to a typical UNIX workstation means replacing the whole machine. As major revisions to the UNIX vendor`s product line come out, brand new systems are introduced. IBM compatibles, however, are modular by design, and nothing need to be replaced except the components that are truly improved. The DAISy cluster, for example, is about to undergo a major upgrade from 90MHz Pentiums to 200MHz Pentium Pros. All of the memory -- the system`s largest expense -- and disks, power supply, etc., can be reused. As a result, commodity workstation clusters ought to gain an increasingly large share of the distributed computing market.

  14. Gas fueling to the central 10pc in merging galaxies.

    NASA Astrophysics Data System (ADS)

    Bekki, K.; Noguchi, M.

    1994-10-01

    Merging galaxies sometimes show quasar-like activity, which suggests that the interstellar gas is efficiently transferred to the vicinity of their nucleus (where a massive black hole is considered to exist.). In order to elucidate gas fueling mechanism in galaxy mergers, we have numerically investigated the dynamical evolution of gas in the late phase of mergers. It is found that in some cases (e.g., a retrograde merger involving two compact galaxy cores), the dynamical heating by two sinking cores and subsequent dissipative cloud-cloud collisions drive a large fraction of disk gas (~10^8^Msun_) into the central 10pc. It is also found that most of models have shown a qualitatively similar behavior that gas infall to the central 10pc becomes prominent only after the coalescence of two cores. This tendency of nuclear activity remains unchanged even if we include gas consumption by star formation in our models. Our numerical study predicts that the radiation emitted from the nuclear region of completed mergers showing a single nucleus originates from accretion power induced activity around a massive black hole whereas star formation is prime energy source of the radiation from less advanced mergers showing two distinct nuclei.

  15. COMPPAP - COMPOSITE PLATE BUCKLING ANALYSIS PROGRAM (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Smith, J. P.

    1994-01-01

    The Composite Plate Buckling Analysis Program (COMPPAP) was written to help engineers determine buckling loads of orthotropic (or isotropic) irregularly shaped plates without requiring hand calculations from design curves or extensive finite element modeling. COMPPAP is a one element finite element program that utilizes high-order displacement functions. The high order of the displacement functions enables the user to produce results more accurate than traditional h-finite elements. This program uses these high-order displacement functions to perform a plane stress analysis of a general plate followed by a buckling calculation based on the stresses found in the plane stress solution. The current version assumes a flat plate (constant thickness) subject to a constant edge load (normal or shear) on one or more edges. COMPPAP uses the power method to find the eigenvalues of the buckling problem. The power method provides an efficient solution when only one eigenvalue is desired. Once the eigenvalue is found, the eigenvector, which corresponds to the plate buckling mode shape, results as a by-product. A positive feature of the power method is that the dominant eigenvalue is the first found, which is this case is the plate buckling load. The reported eigenvalue expresses a load factor to induce plate buckling. COMPPAP is written in ANSI FORTRAN 77. Two machine versions are available from COSMIC: a PC version (MSC-22428), which is for IBM PC 386 series and higher computers and compatibles running MS-DOS; and a UNIX version (MSC-22286). The distribution medium for both machine versions includes source code for both single and double precision versions of COMPPAP. The PC version includes source code which has been optimized for implementation within DOS memory constraints as well as sample executables for both the single and double precision versions of COMPPAP. The double precision versions of COMPPAP have been successfully implemented on an IBM PC 386 compatible running

  16. Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles

    SciTech Connect

    Zhao Baozhong; Yin Junjie; Bilski, Piotr J.; Chignell, Colin F.; Roberts, Joan E.; He Yuying

    2009-12-01

    Nanoparticles have been explored recently as an efficient means of delivering photosensitizers for cancer diagnosis and photodynamic therapy (PDT). Silicon phthalocyanine 4 (Pc4) is currently being clinically tested as a photosensitizer for PDT. Unfortunately, Pc4 aggregates in aqueous solutions, which dramatically reduces its PDT efficacy and therefore limits its clinical application. We have encapsulated Pc4 using silica nanoparticles (Pc4SNP), which not only improved the aqueous solubility, stability, and delivery of the photodynamic drug but also increased its photodynamic efficacy compared to free Pc4 molecules. Pc4SNP generated photo-induced singlet oxygen more efficiently than free Pc4 as measured by chemical probe and EPR trapping techniques. Transmission electron microscopy and dynamic light scattering measurements showed that the size of the particles is in the range of 25-30 nm. Cell viability measurements demonstrated that Pc4SNP was more phototoxic to A375 or B16-F10 melanoma cells than free Pc4. Pc4SNP photodamaged melanoma cells primarily through apoptosis. Irradiation of A375 cells in the presence of Pc4SNP resulted in a significant increase in intracellular protein-derived peroxides, suggesting a Type II (singlet oxygen) mechanism for phototoxicity. More Pc4SNP than free Pc4 was localized in the mitochondria and lysosomes. Our results show that these stable, monodispersed silica nanoparticles may be an effective new formulation for Pc4 in its preclinical and clinical studies. We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future.

  17. G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

    PubMed

    Boortz, Kayla A; Syring, Kristen E; Dai, Chunhua; Pound, Lynley D; Oeser, James K; Jacobson, David A; Wang, Jen-Chywan; McGuinness, Owen P; Powers, Alvin C; O'Brien, Richard M

    2016-08-01

    The glucose-6-phosphatase catalytic 2 (G6PC2) gene is expressed specifically in pancreatic islet beta cells. Genome-wide association studies have shown that single nucleotide polymorphisms in the G6PC2 gene are associated with variations in fasting blood glucose (FBG) but not fasting plasma insulin. Molecular analyses examining the functional effects of these single nucleotide polymorphisms demonstrate that elevated G6PC2 expression is associated with elevated FBG. Studies in mice complement these genome-wide association data and show that deletion of the G6pc2 gene lowers FBG without affecting fasting plasma insulin. This suggests that, together with glucokinase, G6PC2 forms a substrate cycle that determines the glucose sensitivity of insulin secretion. Because genome-wide association studies and mouse studies demonstrate that elevated G6PC2 expression raises FBG and because chronically elevated FBG is detrimental to human health, increasing the risk of type 2 diabetes, it is unclear why G6PC2 evolved. We show here that the synthetic glucocorticoid dexamethasone strongly induces human G6PC2 promoter activity and endogenous G6PC2 expression in isolated human islets. Acute treatment with dexamethasone selectively induces endogenous G6pc2 expression in 129SvEv but not C57BL/6J mouse pancreas and isolated islets. The difference is due to a single nucleotide polymorphism in the C57BL/6J G6pc2 promoter that abolishes glucocorticoid receptor binding. In 6-hour fasted, nonstressed 129SvEv mice, deletion of G6pc2 lowers FBG. In response to the stress of repeated physical restraint, which is associated with elevated plasma glucocorticoid levels, G6pc2 gene expression is induced and the difference in FBG between wild-type and knockout mice is enhanced. These data suggest that G6PC2 may have evolved to modulate FBG in response to stress. PMID:27300767

  18. Thermal Tracking of Sports Players

    PubMed Central

    Gade, Rikke; Moeslund, Thomas B.

    2014-01-01

    We present here a real-time tracking algorithm for thermal video from a sports game. Robust detection of people includes routines for handling occlusions and noise before tracking each detected person with a Kalman filter. This online tracking algorithm is compared with a state-of-the-art offline multi-target tracking algorithm. Experiments are performed on a manually annotated 2-minutes video sequence of a real soccer game. The Kalman filter shows a very promising result on this rather challenging sequence with a tracking accuracy above 70% and is superior compared with the offline tracking approach. Furthermore, the combined detection and tracking algorithm runs in real time at 33 fps, even with large image sizes of 1920 × 480 pixels. PMID:25076219

  19. Thermal tracking of sports players.

    PubMed

    Gade, Rikke; Moeslund, Thomas B

    2014-01-01

    We present here a real-time tracking algorithm for thermal video from a sports game. Robust detection of people includes routines for handling occlusions and noise before tracking each detected person with a Kalman filter. This online tracking algorithm is compared with a state-of-the-art offline multi-target tracking algorithm. Experiments are performed on a manually annotated 2-minutes video sequence of a real soccer game. The Kalman filter shows a very promising result on this rather challenging sequence with a tracking accuracy above 70% and is superior compared with the offline tracking approach. Furthermore, the combined detection and tracking algorithm runs in real time at 33 fps, even with large image sizes of 1920 × 480 pixels. PMID:25076219

  20. Thermal tracking of sports players.

    PubMed

    Gade, Rikke; Moeslund, Thomas B

    2014-07-29

    We present here a real-time tracking algorithm for thermal video from a sports game. Robust detection of people includes routines for handling occlusions and noise before tracking each detected person with a Kalman filter. This online tracking algorithm is compared with a state-of-the-art offline multi-target tracking algorithm. Experiments are performed on a manually annotated 2-minutes video sequence of a real soccer game. The Kalman filter shows a very promising result on this rather challenging sequence with a tracking accuracy above 70% and is superior compared with the offline tracking approach. Furthermore, the combined detection and tracking algorithm runs in real time at 33 fps, even with large image sizes of 1920 × 480 pixels.

  1. Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression

    PubMed Central

    Boortz, Kayla A.; Syring, Kristen E.; Pound, Lynley D.; Wang, Yingda; Oeser, James K.; O’Brien, Richard M.

    2016-01-01

    Elevated fasting blood glucose (FBG) has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using G6pc2 knockout mice suggest that G6pc2 regulates the glucose sensitivity of insulin secretion. G6PC2 and the related G6PC1 and G6PC3 genes encode glucose-6-phosphatase catalytic subunits. This study describes a functional analysis of 22 non-synonymous G6PC2 SNPs, that alter amino acids that are conserved in human G6PC1, mouse G6pc1 and mouse G6pc2, with the goal of identifying variants that potentially affect G6PC2 activity/expression. Published data suggest strong conservation of catalytically important amino acids between all four proteins and the related G6PC3 isoform. Because human G6PC2 has very low glucose-6-phosphatase activity we used an indirect approach, examining the effect of these SNPs on mouse G6pc1 activity. Using a novel in situ functional assay for glucose-6-phosphatase activity we demonstrate that the amino acid changes associated with the human G6PC2 rs144254880 (Arg79Gln), rs149663725 (Gly114Arg) and rs2232326 (Ser324Pro) SNPs reduce mouse G6pc1 enzyme activity without affecting protein expression. The Arg79Gln variant alters an amino acid mutation of which, in G6PC1, has previously been shown to cause glycogen storage disease type 1a. We also demonstrate that the rs368382511 (Gly8Glu), rs138726309 (His177Tyr), rs2232323 (Tyr207Ser) rs374055555 (Arg293Trp), rs2232326 (Ser324Pro), rs137857125 (Pro313Leu) and rs2232327 (Pro340Leu) SNPs confer decreased G6PC2 protein expression. In summary, these studies identify multiple G6PC2 variants that have the potential to be associated with altered FBG in humans. PMID:27611587

  2. Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.

    PubMed

    Boortz, Kayla A; Syring, Kristen E; Pound, Lynley D; Wang, Yingda; Oeser, James K; O'Brien, Richard M

    2016-01-01

    Elevated fasting blood glucose (FBG) has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs) in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using G6pc2 knockout mice suggest that G6pc2 regulates the glucose sensitivity of insulin secretion. G6PC2 and the related G6PC1 and G6PC3 genes encode glucose-6-phosphatase catalytic subunits. This study describes a functional analysis of 22 non-synonymous G6PC2 SNPs, that alter amino acids that are conserved in human G6PC1, mouse G6pc1 and mouse G6pc2, with the goal of identifying variants that potentially affect G6PC2 activity/expression. Published data suggest strong conservation of catalytically important amino acids between all four proteins and the related G6PC3 isoform. Because human G6PC2 has very low glucose-6-phosphatase activity we used an indirect approach, examining the effect of these SNPs on mouse G6pc1 activity. Using a novel in situ functional assay for glucose-6-phosphatase activity we demonstrate that the amino acid changes associated with the human G6PC2 rs144254880 (Arg79Gln), rs149663725 (Gly114Arg) and rs2232326 (Ser324Pro) SNPs reduce mouse G6pc1 enzyme activity without affecting protein expression. The Arg79Gln variant alters an amino acid mutation of which, in G6PC1, has previously been shown to cause glycogen storage disease type 1a. We also demonstrate that the rs368382511 (Gly8Glu), rs138726309 (His177Tyr), rs2232323 (Tyr207Ser) rs374055555 (Arg293Trp), rs2232326 (Ser324Pro), rs137857125 (Pro313Leu) and rs2232327 (Pro340Leu) SNPs confer decreased G6PC2 protein expression. In summary, these studies identify multiple G6PC2 variants that have the potential to be associated with altered FBG in humans. PMID:27611587

  3. Cell tracking 2007: a proliferation of probes and applications.

    PubMed

    Wallace, Paul K; Muirhead, Katharine A

    2007-01-01

    The articles in this thematic issue, entitled "Tracking Cell Proliferation and Function," illustrate some of the choices made by authors pushing the envelope for cell tracking applications in their areas of interest. Over the past decade there has been a proliferation in the range of commercially available probes for these studies, the capabilities of the instrumentation used to detect them, and in the biological systems being studied. This introductory to the thematic issue presents the advantages and limitations of the more commonly used probes such as CFSE and PKH26, as well as emerging probes that expand the range of fluorescence available, including quantum dots and the new CellVue dyes. Appropriate method and instrument setup controls and possible data analysis strategies are discussed with the goal of urging experienced investigators to include all critical information and controls when publishing their data and of aiding researchers new to cell tracking to make informed decisions on which cell tracking reagent(s) are best suited for their particular application. All cell tracking assays have the common goal of determining the fate of a particular cell population within a heterogeneous environment, whether in vivo or in vitro. Some of the common themes among the contributions found in this issue include how various probes are used to track (i) cell proliferation, (ii) regulatory and effector immune cell function and (iii) membrane transfer and antigen presentation. Although these represent only a small fraction of the large and growing list of applications for cell tracking, clearly illustrate the growing trend toward the use of multiple tracking reagents and multiple detection modalities to address complex biological questions.

  4. Toxicogenomics and the Regulatory Framework

    EPA Science Inventory

    Toxicogenomics presents regulatory agencies with the opportunity to revolutionize their analyses by enabling the collection of information on a broader range of responses than currently considered in traditional regulatory decision making. Analyses of genomic responses are expec...

  5. SRC2-1 is required in PcINF1-induced pepper immunity by acting as an interacting partner of PcINF1.

    PubMed

    Liu, Zhi-qin; Qiu, Ai-lian; Shi, Lan-ping; Cai, Jin-sen; Huang, Xue-ying; Yang, Sheng; Wang, Bo; Shen, Lei; Huang, Mu-kun; Mou, Shao-liang; Ma, Xiao-Ling; Liu, Yan-yan; Lin, Lin; Wen, Jia-yu; Tang, Qian; Shi, Wei; Guan, De-yi; Lai, Yan; He, Shui-lin

    2015-07-01

    Elicitins are elicitors that can trigger hypersensitive cell death in most Nicotiana spp., but their underlying molecular mechanism is not well understood. The gene Phytophthora capsici INF1 (PcINF1) coding for an elicitin from P. capsici was characterized in this study. Transient overexpression of PcINF1 triggered cell death in pepper (Capsicum annuum L.) and was accompanied by upregulation of the hypersensitive response marker, Hypersensitive Induced Reaction gene 1 (HIR1), and the pathogenesis-related genes SAR82, DEF1, BPR1, and PO2. A putative PcINF1-interacting protein, SRC2-1, was isolated from a pepper cDNA library by yeast two-hybrid screening and was observed to target the plasma membrane. The interaction between PcINF1 and SRC2-1 was confirmed by bimolecular fluorescence complementation and co-immunoprecipitation. Simultaneous transient overexpression of SRC2-1 and PcINF1 in pepper plants triggered intensive cell death, whereas silencing of SRC2-1 by virus-induced gene silencing blocked the cell death induction of PcINF1 and increased the susceptibility of pepper plants to P. capsici infection. Additionally, membrane targeting of the PcINF1-SRC2-1 complex was required for cell death induction. The C2 domain of SRC2-1 was crucial for SRC2-1 plasma membrane targeting and the PcINF1-SRC2-1 interaction. These results suggest that SRC2-1 interacts with PcINF1 and is required in PcINF1-induced pepper immunity.

  6. Nuclear Regulatory Commission information digest

    SciTech Connect

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  7. 12 CFR 562.2 - Regulatory reports.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of the special supervisory, regulatory, and economic policy needs served by such reports. Regulatory... reflects the underlying economic substance of the transaction at issue. Regulatory reporting...

  8. 49 CFR 213.331 - Track surface.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Track surface. 213.331 Section 213.331... Track surface. (a) For a single deviation in track surface, each track owner shall maintain the surface of its track within the limits prescribed in the following table: Track surface (inches) Class...

  9. 49 CFR 213.331 - Track surface.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Track surface. 213.331 Section 213.331... Track surface. (a) For a single deviation in track surface, each track owner shall maintain the surface of its track within the limits prescribed in the following table: Track surface (inches) Class...

  10. 49 CFR 213.63 - Track surface.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Track surface. 213.63 Section 213.63..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Track Geometry § 213.63 Track surface. Each owner of the track to which this part applies shall maintain the surface of its track within the limits prescribed...

  11. Regulatory Compliance Requirements for an Open Source Electronic Image Trial Management System

    PubMed Central

    Rhodes, Colin; Moore, Steve; Clark, Ken; Maffitt, David; Perry, John; Handzel, Toni; Prior, Fred

    2015-01-01

    There is a global need for software to manage imaging based clinical trials to speed basic research and drug development. Such a system must comply with regulatory requirements. The U.S. Food and Drug Administration (FDA) has regulations regarding software development process controls and data provenance tracking. A key unanswered problem is the identification of which data changes are significant given a workflow model for image trial management. We report on the results of our study of provenance tracking requirements and define an architecture and software development process that meets U.S. regulatory requirements using open source software components. PMID:21097264

  12. Longitudinal frequency variation of long-lasting EMIC Pc1-Pc2 waves localized in the inner magnetosphere

    NASA Astrophysics Data System (ADS)

    Kim, K.-H.; Shiokawa, K.; Mann, I. R.; Park, J.-S.; Kwon, H.-J.; Hyun, K.; Jin, H.; Connors, M.

    2016-02-01

    Long-lasting (> 20 h) electromagnetic ion cyclotron (EMIC) Pc1-Pc2 waves were observed by the Athabasca (L =˜ 4.6) induction magnetometer and Canadian Array for Realtime Investigations of Magnetic Activity (L =˜ 4-6) fluxgate magnetometers on 5 April 2007. These waves showed a systematic frequency change with local time, the minimum frequency near dusk, and the maximum frequency near dawn. Assuming the plasmapause as a potential source region of the waves, we estimated the plasmapause location from localized proton enhancement (LPE) events observed at NOAA-Polar Orbiting Environmental Satellites and METOP-2 satellites. We found that the longitudinal frequency variation of EMIC waves has a clear correlation with the estimated plasmapause location and that the waves are in the frequency band between the equatorial helium and oxygen gyrofrequencies at the estimated plasmapause. With our analysis results we suggest that the LPE events are caused by wave-particle interaction with the helium band EMIC waves generated near the plasmapause.

  13. 78 FR 44329 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ....nasa.gov/open . Timetable: Action Date FR Cite NPRM 10/00/13 Regulatory Flexibility Analysis Required... Administration (NASA). ACTION: Semiannual regulatory agenda. SUMMARY: NASA's regulatory agenda describes those regulations being considered for development or amendment by NASA, the need and legal basis for the...

  14. 75 FR 79759 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... Action 04/16/10 75 FR 2012 Regulatory Flexibility Analysis Required: Yes Agency Contact: Mohammed Khan... ``Regulatory Planning and Review,'' 58 FR 51735, and the Regulatory Flexibility Act, 5 U.S.C. 601 et seq... use throughout the rulemaking process. Timetable: Action Date FR Cite Notice: Public Meeting...

  15. Rover wheel & tracks - color

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This view from the Sojourner rover's rear color camera shows wheel tracks in the orange-red martian soil. One of the rover's cleated wheels is visible at left.

    Mars Pathfinder is the second in NASA's Discovery program of low-cost spacecraft with highly focused science goals. The Jet Propulsion Laboratory, Pasadena, CA, developed and manages the Mars Pathfinder mission for NASA's Office of Space Science, Washington, D.C. JPL is an operating division of the California Institute of Technology (Caltech).

  16. Optical correlator tracking nonlinearity

    NASA Astrophysics Data System (ADS)

    Gregory, Don A.; Kirsch, James C.; Johnson, John L.

    1987-01-01

    A limitation observed in the tracking ability of optical correlators is reported. It is shown by calculations that an inherent nonlinearity exists in many optical correlator configurations, with the problem manifesting itself in a mismatch of the input scene with the position of the correlation signal. Results indicate that some care must be given to the selection of components and their configuration in constructing an optical correlator which exhibits true translational invariance. An input test scene is shown along with the correlation spot and cross hairs from a contrast detector; the offset is apparent.

  17. Noninvasive assessment of tissue distribution and tumor pharmacokinetics of Pc 181, a silicon phthalocyanine analogue, in mice

    NASA Astrophysics Data System (ADS)

    Bai, Lihua; Guo, Jianxia; Clausen, Dana M.; Eiseman, Julie L.

    2010-02-01

    Objective: In in vitro photodynamic therapy, the LD50 of Pc 181 has been reported to be 7 to 8 times less than that of silicon phthalocyanine 4 (Pc 4). The Optical Pharmacokinetic System (OPS) can measure photosensitizer concentrations in accessible tissues non-invasively. We used OPS to evaluate the tumor pharmacokinetics of Pc 181 and Pc 4 and the tissue drug distribution in SCID mice bearing either human breast cancer MDA-MB-231 or human head and neck squamous cell carcinoma SCC-15 xenografts. Methods: Following iv administration of 2.5 mg/kg Pc 181 or 2 mg/kg Pc 4 to SCID mice, OPS measurements were taken on tumor and normal tissues between 5 and 4320 min in vivo or in situ. Results: Large variations in tumor Pc 181 concentrations were observed among mice. In MDA-MB-231 tumors, the Pc 181 concentration peaked at 240 min, and was retained in the tumor. Tumor Pc 181 concentrations were much less than the tumor Pc 4 concentrations at an equimolar dose. Pc 181 concentrations were the highest in liver, followed by spleen, and kidney. In mice bearing SCC-15 xenografts, skin and underlying tissue Pc 181 concentrations were higher than tumor concentrations at all time points examined. Conclusions: This first Pc 181 pharmacokinetics study described a tissue Pc 181 distribution similar to that of Pc 4. However, tumor Pc 181 concentrations were lower than those of Pc 4 at equimolar doses.

  18. Establishing regulatory priorities

    SciTech Connect

    Pontius, F.W.

    1995-12-01

    Statutory deadlines for setting regulations under the 1986 Safe Drinking Water Act (SDWA) have not been met. Faced with limited resources, the US Environmental Protection Agency (USEPA) has historically set regulatory priorities based on perceived need, politics, and legal deadlines. This has resulted in a fragmented regulatory program and confusion on the part of the regulated community and on the part of other stakeholders. Even though the agency has been subject to court-imposed deadlines for most new regulations, resource limitations have caused these deadlines to be missed, resulting in new court-imposed deadlines. In 1994, the agency began considering a new approach for determining how many regulations can be developed and in what order. A draft strategic plan was prepared in December 1994. Based on discussion of this plan, USEPA requested the US District Court for Oregon to extend certain regulatory deadlines so that new priorities could be set for the highest-risk substances. An extension was granted until Aug. 1, 1995, and was subsequently extended to Dec. 15, 1995.

  19. Regulatory aspects on nanomedicines.

    PubMed

    Sainz, Vanessa; Conniot, João; Matos, Ana I; Peres, Carina; Zupancic, Eva; Moura, Liane; Silva, Liana C; Florindo, Helena F; Gaspar, Rogério S

    2015-12-18

    Nanomedicines have been in the forefront of pharmaceutical research in the last decades, creating new challenges for research community, industry, and regulators. There is a strong demand for the fast development of scientific and technological tools to address unmet medical needs, thus improving human health care and life quality. Tremendous advances in the biomaterials and nanotechnology fields have prompted their use as promising tools to overcome important drawbacks, mostly associated to the non-specific effects of conventional therapeutic approaches. However, the wide range of application of nanomedicines demands a profound knowledge and characterization of these complex products. Their properties need to be extensively understood to avoid unpredicted effects on patients, such as potential immune reactivity. Research policy and alliances have been bringing together scientists, regulators, industry, and, more frequently in recent years, patient representatives and patient advocacy institutions. In order to successfully enhance the development of new technologies, improved strategies for research-based corporate organizations, more integrated research tools dealing with appropriate translational requirements aiming at clinical development, and proactive regulatory policies are essential in the near future. This review focuses on the most important aspects currently recognized as key factors for the regulation of nanomedicines, discussing the efforts under development by industry and regulatory agencies to promote their translation into the market. Regulatory Science aspects driving a faster and safer development of nanomedicines will be a central issue for the next years.

  20. Putting Off-Track Youths Back on Track to College

    ERIC Educational Resources Information Center

    Steinberg, Adria; Allen, Lili

    2011-01-01

    Back on Track, developed by Jobs for the Future, is a design for schools to not only re-engage off-track and out-of-school youths to graduate from high school, but also to put them on a clear, supported path to a college education. Two schools that have combined Back on Track with the early college model, in which students can earn both a high…

  1. PC Index as a Means to Monitor Processes in the Auroral Zone

    NASA Astrophysics Data System (ADS)

    Troshichev, Oleg

    2016-07-01

    The PC index was introduced [Troshichev et al., 1988] to characterize the polar cap magnetic activity generated by the geoeffective interplanetary electric field. Results of recent studies [Troshichev and Janzhura, 2012; Troshichev and Sormakov, 2015] are strongly indicative of PC index as a proxy of the solar wind energy that entered into the magnetosphere. The PC index in this charge can be successfully used to monitor processes in the auroral zone: 1. PC index well correlates with intensity of the Region 1 field-aligned currents measured by SWARM satellites on the auroral oval poleward boundary. As it is known, the R1 field-aligned currents flow into ionosphere in the morning auroral oval and flow out of ionosphere in the evening oval. The R1 FAC intensity and, correspondingly, the PC value increase in tandem before the substorm sudden onset. 2. PC-index can be taken as Input Parameter in Empirical Auroral Precipitation Model "OVATION-prime" [Newell, 2009] instead of the coupling function dØMP/dt. Use of the 1-min PC index in the modified OVATION-PC model provides the much better timing of the auroral precipitation with allowance for actual state of the magnetosphere. 3. There is a strong correspondence between the behavior of PC and development of magnetic disturbances in the auroral zone: the magnetic substorms are preceded by the PC index growth, the substorm onsets are commonly associated with a sharp increase in the PC growth rate, the substorm occurrence reaches the maximum when PC exceeds the threshold value ~ 1.5±0.5 mV/m, the linear correlation between the PC and AL values is typical of all classes of substorms, irrespective of their power. There regularities provide possibility to nowcast the substorm development.

  2. Storage tracking refinery trends

    SciTech Connect

    Saunders, J.

    1996-05-01

    Regulatory and marketplace shakeups have made the refining and petrochemical industries highly competitive. The fight to survive has forced refinery consolidations, upgrades and companywide restructurings. Bulk liquid storage terminals are following suit. This should generate a flurry of engineering and construction by the latter part of 1997. A growing petrochemical industry translates into rising storage needs. Industry followers forecasted flat petrochemical growth in 1996 due to excessive expansion in 1994 and 1995. But expansion is expected to continue throughout this year on the strength of several products.

  3. Particle displacement tracking applied to air flows

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.

    1991-01-01

    Electronic Particle Image Velocimetric (PIV) techniques offer many advantages over conventional photographic PIV methods such as fast turn around times and simplified data reduction. A new all electronic PIV technique was developed which can measure high speed gas velocities. The Particle Displacement Tracking (PDT) technique employs a single CW laser, small seed particles (1 micron), and a single intensified, gated CCD array frame camera to provide a simple and fast method of obtaining two-dimensional velocity vector maps with unambiguous direction determination. Use of a single CCD camera eliminates registration difficulties encountered when multiple cameras are used to obtain velocity magnitude and direction information. An 80386 PC equipped with a large memory buffer frame-grabber board provides all of the data acquisition and data reduction operations. No array processors of other numerical processing hardware are required. Full video resolution (640 x 480 pixel) is maintained in the acquired images, providing high resolution video frames of the recorded particle images. The time between data acquisition to display of the velocity vector map is less than 40 sec. The new electronic PDT technique is demonstrated on an air nozzle flow with velocities less than 150 m/s.

  4. Particle displacement tracking applied to air flows

    NASA Technical Reports Server (NTRS)

    Wernet, Mark P.

    1991-01-01

    Electronic Particle Image Velocimeter (PIV) techniques offer many advantages over conventional photographic PIV methods such as fast turn around times and simplified data reduction. A new all electronic PIV technique was developed which can measure high speed gas velocities. The Particle Displacement Tracking (PDT) technique employs a single cw laser, small seed particles (1 micron), and a single intensified, gated CCD array frame camera to provide a simple and fast method of obtaining two-dimensional velocity vector maps with unambiguous direction determination. Use of a single CCD camera eliminates registration difficulties encountered when multiple cameras are used to obtain velocity magnitude and direction information. An 80386 PC equipped with a large memory buffer frame-grabber board provides all of the data acquisition and data reduction operations. No array processors of other numerical processing hardware are required. Full video resolution (640x480 pixel) is maintained in the acquired images, providing high resolution video frames of the recorded particle images. The time between data acquisition to display of the velocity vector map is less than 40 sec. The new electronic PDT technique is demonstrated on an air nozzle flow with velocities less than 150 m/s.

  5. Operational specifications of the laser illuminated track etch scattering dosemeter reader.

    PubMed

    Moore, M E; Gepford, H J; Hoffman, J M; McKeever, R J; Devine, R T

    2006-01-01

    The personnel dosimetry operations team at the Los Alamos National Laboratory (LANL) has accepted the laser illuminated track etch scattering (LITES) dosemeter reader into its suite of radiation dose measurement instruments. The LITES instrument transmits coherent light from a He-Ne laser through the pertinent track etch foil and a photodiode measures the amount of light scattered by the etched tracks. A small beam stop blocks the main laser light, while a lens refocuses the scattered light into the photodiode. Three stepper motors in the current LITES system are used to position a carousel that holds 36 track etch dosemeters (TEDs). Preliminary work with the LITES system demonstrated the device had a linear response in counting foils subjected to exposures up to 50 mSv (5.0 rem). The United States Department of Energy requires that the annual general employee dose not exceed 50 mSv (5.0 rem). On a regular basis, LANL uses the Autoscan-60 reader system (Thermo Electron Corp.) for counting track etch dosemeters. However, LANL uses a 15 h etch process for CR-39 dosemeters, and this produces more and larger track etch pits than the 6 h etch used by many institutions. Therefore, LANL only uses the Autoscan-60 for measuring neutron dose equivalent up to exposure levels of approximately 3 mSv (300 mrem). The LITES system has a measured lower limit of detection of approximately 0.6 mSv (60 mrem), and it has a correlation coefficient of R (2) = 0.99 over an exposure range up to 500 mSv (50.0 rem). A series of blind studies were done using three methods: the Autoscan-60 system, manual counting by optical microscope and the LITES instrument. A collection of track etch dosemeters of unknown neutron dose equivalent (NDE) were analysed using the three methods, and the performance coefficient (PC) was calculated when the NDE became known. The Autoscan-60 and optical microscope methods had a combined PC = 0.171, and the LITES instrument had a PC = 0.194, where a PC less than or

  6. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Stan Wohadlo

    2001-03-31

    The overall project objective is the development and validation of an innovative coal combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers without the need for post-combustion cleaning. Work during the quarter included initiation of the equipment fabrication effort for all pilot system components. Fabrication of the gas-fired combustor was started and completed by IGT during the quarter. The combustor was then installed in IGT's combustion laboratory for proof-of-performance testing prior to shipping to BBP for installation in the pilot-scale test system. A testing procedure and performance goals were developed for the combustor testing.

  7. METHANE de-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Joseph Rabovitser

    2000-07-05

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to make this technology ready for full-scale commercial deployment by 2002-2003 in order to meet an anticipated market demand for NO{sub x} reduction technologies resulting from the EPA's NO{sub x} SIP call.

  8. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Joseph Rabovitser; Bruce Bryan; Serguei Nester; Stan Wohadlo

    2001-06-30

    The project seeks to develop and validate a new pulverized coal combustion system to reduce utility PC boiler NO{sub x} emissions to 0.15 lb/million Btu or less without post-combustion flue gas cleaning. Work during the quarter included continuation of the equipment fabrication effort for pilot system components. Successful proof-of-performance testing of the IGT-designed pilot-scale natural gas-fired coal preheat combustor was completed by IGT during the quarter. The combustor was then disassembled and shipped for installation in the pilot-scale test system in BBP's Coal Burner Test Facility (CBTF) in Worcester, MA. Delivery of the balance of the pilot system components from the fabricator began near the end of the quarter, with components being installed in the pilot test facility as they were received.

  9. Charge recombination in CuPc/PTCDA thin films.

    PubMed

    Heutz, S; Nogueira, A F; Durrant, J R; Jones, T S

    2005-06-16

    The recombination kinetics of photogenerated charge carriers in perylene-3, 4, 9, 10-tetracarboxylic dianhydride (PTCDA) and copper phthalocyanine (CuPc) thin films grown by organic molecular beam deposition have been studied using transient absorption spectroscopy. Optical excitation is observed to generate long-lived polaron states, which exhibit power law recombination dynamics on time scales from microseconds to milliseconds. Studies as a function of excitation density and temperature, and comparison between heterostructures and PTCDA single layers, all indicate that this power law behavior results from trapping of PTCDA- polarons in localized states, with an estimated trap state density of approximately 6 x 10(17) polarons cm(-3). This recombination behavior is found to be remarkably similar to that previously observed for polymer/fullerene blends, suggesting that it may be generic to a range of semiconducting materials.

  10. Personal Computer (PC) based image processing applied to fluid mechanics

    NASA Technical Reports Server (NTRS)

    Cho, Y.-C.; Mclachlan, B. G.

    1987-01-01

    A PC based image processing system was employed to determine the instantaneous velocity field of a two-dimensional unsteady flow. The flow was visualized using a suspension of seeding particles in water, and a laser sheet for illumination. With a finite time exposure, the particle motion was captured on a photograph as a pattern of streaks. The streak pattern was digitized and processed using various imaging operations, including contrast manipulation, noise cleaning, filtering, statistical differencing, and thresholding. Information concerning the velocity was extracted from the enhanced image by measuring the length and orientation of the individual streaks. The fluid velocities deduced from the randomly distributed particle streaks were interpolated to obtain velocities at uniform grid points. For the interpolation a simple convolution technique with an adaptive Gaussian window was used. The results are compared with a numerical prediction by a Navier-Stokes computation.

  11. Falling PC Solitaire Cards: An Open-Inquiry Approach

    NASA Astrophysics Data System (ADS)

    González-Espada, Wilson J.

    2012-09-01

    Many of us have played the PC Solitaire game that comes as standard software in many computers. Although I am not a great player, occasionally I win a game or two. The game celebrates my accomplishment by pushing the cards forward, one at a time, falling gracefully in what appears to look like a parabolic path in a drag-free environment. One day, as I was watching this progression, I asked myself what is the downward acceleration of the playing cards. Could the game programmer have used a realistic value of Earth's acceleration due to gravity? It occurred to me that this could be an excellent open-inquiry activity for high school or introductory college physics students!

  12. Implementation of PC and PNDT Act in Gulbarga region.

    PubMed

    Mudda, Vandana; Uzair, Syed H

    2014-01-01

    Denial to a girl child of her right to live is one of the heinous violations of the right to life committed by the society. Gender bias and deep rooted prejudice and discrimination against girl child and preference of male child have led to large scale female foeticide in the last decade. The declining sex ratio is a major concern for all. The census 2001 data indicates that female ratio is declining at an alarming rate and needs immediate action. In order to check the female foeticide, the Prenatal Diagnostic Techniques (regulation and prevention of misuse) Act 1994 was enacted and became operational from January, 1996. This article is an attempt to throw light on the successful implementatuion of PC and PNDT Act in the Gulbarga region and active participation of various organisations and people in proper implementation of the act.

  13. Monte Carlo Simulations on a 9-node PC Cluster

    NASA Astrophysics Data System (ADS)

    Gouriou, J.

    Monte Carlo simulation methods are frequently used in the fields of medical physics, dosimetry and metrology of ionising radiation. Nevertheless, the main drawback of this technique is to be computationally slow, because the statistical uncertainty of the result improves only as the square root of the computational time. We present a method, which allows to reduce by a factor 10 to 20 the used effective running time. In practice, the aim was to reduce the calculation time in the LNHB metrological applications from several weeks to a few days. This approach includes the use of a PC-cluster, under Linux operating system and PVM parallel library (version 3.4). The Monte Carlo codes EGS4, MCNP and PENELOPE have been implemented on this platform and for the two last ones adapted for running under the PVM environment. The maximum observed speedup is ranging from a factor 13 to 18 according to the codes and the problems to be simulated.

  14. Stochastic acceleration of ions driven by Pc1 wave packets

    SciTech Connect

    Khazanov, G. V. Sibeck, D. G.; Tel'nikhin, A. A.; Kronberg, T. K.

    2015-07-15

    The stochastic motion of protons and He{sup +} ions driven by Pc1 wave packets is studied in the context of resonant particle heating. Resonant ion cyclotron heating typically occurs when wave powers exceed 10{sup −4} nT{sup 2}/Hz. Gyroresonance breaks the first adiabatic invariant and energizes keV ions. Cherenkov resonances with the electrostatic component of wave packets can also accelerate ions. The main effect of this interaction is to accelerate thermal protons to the local Alfven speed. The dependencies of observable quantities on the wave power and plasma parameters are determined, and estimates for the heating extent and rate of particle heating in these wave-particle interactions are shown to be in reasonable agreement with known empirical data.

  15. A PC-Based Free Text DSS for Health Care

    NASA Technical Reports Server (NTRS)

    Grams, Ralph R.; Buchanan, Paul; Massey, James K.; Jin, Ming

    1987-01-01

    A free Decision Support System(DST) has been constructed for health care professional that allows the analysis of complex medical cases and the creation of diagnostic list of potential diseases for clinical evaluation.The system uses a PC-based text management system specifically designed for desktop operation. The texts employed in the decision support package include the Merck Manual (published by Merck Sharpe & Dohme) and Control of Communicable Diseas in Man (published by the American Public Health Association). The background and design of the database are discussed along with a structured analysis procedure for handling free text DSS system. A case study is presented to show the application of this technology and conclusions are drawn in the summary that point to expanded areas of professional intention and new frontiers yet to be explored in this rapidly progressing field.

  16. Parallel processing of ADS40 images on PC network

    NASA Astrophysics Data System (ADS)

    Qiu, Feng; Duan, Yansong; Zhang, Jianqing

    2009-10-01

    In this paper, we aim to design a parallel processing system based on economic hardware environment to optimize photogrammetric process of Leica ADS40 images considering ideas and methods of parallel computing. We adopt parallel computing PCAM principle to design and implement a test system for parallel processing of ADS40 images. The test system consists of common personal computers and local gigabits network. It can make full use of network computing and storage resources under a economical and practical cost to deal with ADS40 images. Experiment shows that it achieves significant improvement of processing efficiency. Furthermore, the robustness and compatibility of this system is much higher than stand alone computer system because of system's redundancy based on network. In conclusion, parallel processing system based on PC network brings us a much more efficiency solution of ADS40's photogrammetric production.

  17. Audio podcasting in a tablet PC-enhanced biochemistry course.

    PubMed

    Lyles, Heather; Robertson, Brian; Mangino, Michael; Cox, James R

    2007-11-01

    This report describes the effects of making audio podcasts of all lectures in a large, basic biochemistry course promptly available to students. The audio podcasts complement a previously described approach in which a tablet PC is used to annotate PowerPoint slides with digital ink to produce electronic notes that can be archived. The fundamentals of this approach are described, and data from student attitudinal and informational surveys are presented. The survey data suggest that the students have a positive attitude toward the combination of tablet-based instruction and audio podcasting. In addition, three students provide testimonials on how these technological tools allowed them to utilize their preferred learning styles to succeed in the course. Possible negative consequences of this approach, in terms of class attendance and note taking, are also analyzed and discussed.

  18. Applying a PC accelerator board for medical imaging.

    PubMed

    Gray, J; Grenzow, F; Siedband, M

    1990-01-01

    An AT-compatible computer was used to expand X-ray images that had been compressed and stored on optical data cards. Initially, execution time for expansion of a single X-ray image was 25 min. The requirements were for an expansion time of under 10 s and costs of under $1000 for computing hardware. This meant a computational speed increase of over 150 times was needed. Tests showed that incorporating an 80287 coprocessor would only give a speed increase of five times. The DSP32-PC-160 floating-point accelerator board was selected as a cost-effective solution to the need for more computing power. This board provided adequate processor speed, onboard memory, and data bus width; floating-point math precision; and a high-level language compiler for code development.

  19. Cassini Archive Tracking System

    NASA Technical Reports Server (NTRS)

    Conner, Diane; Sayfi, Elias; Tinio, Adrian

    2006-01-01

    The Cassini Archive Tracking System (CATS) is a computer program that enables tracking of scientific data transfers from originators to the Planetary Data System (PDS) archives. Without CATS, there is no systematic means of locating products in the archive process or ensuring their completeness. By keeping a database of transfer communications and status, CATS enables the Cassini Project and the PDS to efficiently and accurately report on archive status. More importantly, problem areas are easily identified through customized reports that can be generated on the fly from any Web-enabled computer. A Web-browser interface and clearly defined authorization scheme provide safe distributed access to the system, where users can perform functions such as create customized reports, record a transfer, and respond to a transfer. CATS ensures that Cassini provides complete science archives to the PDS on schedule and that those archives are available to the science community by the PDS. The three-tier architecture is loosely coupled and designed for simple adaptation to multimission use. Written in the Java programming language, it is portable and can be run on any Java-enabled Web server.

  20. Integrated Management Tracking System

    SciTech Connect

    Garrett, Terrance

    2000-03-30

    The Integrated Management Tracking System (IMTS) is a "Web Enabled" Client/Server Business application that provides for the Identification and Resolution of commitments, situations, events and problems. The IMTS engine is written with Microsoft Active Server Pages (ASP) for IIS4. The system provides for reporting, entering, editing, closing and administration over a Intranet, Extranet or Internet. This Application facilitates: Electronic assignment, acceptance and tracking to completion. Email notifications of assigned action. Establishment of Due Dates. Electronic search and retrieval based on keywords in combination with user specified database parameters (Document Type, Date Ranges, etc.). Coded for Trending and Reporting. User selected reports. Various levels of access for reports and administration. The "Server" side of this application consists of a Microsoft Access database running on a NT Server with Internet Information Server (IIS). As the "Client" side of the application runs on any Web browser, this solution is a cost effective, user friendly application that lends itself to organizations not physically colocated in one location providing information immediately available to everyone at once.

  1. Automated call tracking systems

    SciTech Connect

    Hardesty, C.

    1993-03-01

    User Services groups are on the front line with user support. We are the first to hear about problems. The speed, accuracy, and intelligence with which we respond determines the user`s perception of our effectiveness and our commitment to quality and service. To keep pace with the complex changes at our sites, we must have tools to help build a knowledge base of solutions, a history base of our users, and a record of every problem encountered. Recently, I completed a survey of twenty sites similar to the National Energy Research Supercomputer Center (NERSC). This informal survey reveals that 27% of the sites use a paper system to log calls, 60% employ homegrown automated call tracking systems, and 13% use a vendor-supplied system. Fifty-four percent of those using homegrown systems are exploring the merits of switching to a vendor-supplied system. The purpose of this paper is to provide guidelines for evaluating a call tracking system. In addition, insights are provided to assist User Services groups in selecting a system that fits their needs.

  2. Integrated Management Tracking System

    2000-03-30

    The Integrated Management Tracking System (IMTS) is a "Web Enabled" Client/Server Business application that provides for the Identification and Resolution of commitments, situations, events and problems. The IMTS engine is written with Microsoft Active Server Pages (ASP) for IIS4. The system provides for reporting, entering, editing, closing and administration over a Intranet, Extranet or Internet. This Application facilitates: Electronic assignment, acceptance and tracking to completion. Email notifications of assigned action. Establishment of Due Dates. Electronicmore » search and retrieval based on keywords in combination with user specified database parameters (Document Type, Date Ranges, etc.). Coded for Trending and Reporting. User selected reports. Various levels of access for reports and administration. The "Server" side of this application consists of a Microsoft Access database running on a NT Server with Internet Information Server (IIS). As the "Client" side of the application runs on any Web browser, this solution is a cost effective, user friendly application that lends itself to organizations not physically colocated in one location providing information immediately available to everyone at once.« less

  3. How to reveal the exotic nature of the Pc(4450 )

    NASA Astrophysics Data System (ADS)

    Guo, Feng-Kun; Meißner, Ulf-G.; Wang, Wei; Yang, Zhi

    2015-10-01

    The LHCb Collaboration announced two pentaquark-like structures in the J /ψ p invariant mass distribution. We show that the current information on the narrow structure at 4.45 GeV is compatible with kinematical effects of the rescattering from χc 1p to J /ψ p : First, it is located exactly at the χc 1p threshold. Second, the mass of the four-star well-established Λ (1890 ) is such that a leading Landau singularity from a triangle diagram can coincidentally appear at the χc 1p threshold, and third, there is a narrow structure at the χc 1p threshold but not at the χc 0p and χc 2p thresholds. In order to check whether that structure corresponds to a real exotic resonance, one can measure the process Λb0→K-χc 1p . If the Pc(4450 ) structure exists in the χc 1p invariant mass distribution as well, then the structure cannot be just a kinematical effect but is a real resonance; otherwise, one cannot conclude that Pc(4450 ) is another exotic hadron. In addition, it is also worthwhile to measure the decay ϒ (1 S )→J /ψ p p ¯ : a narrow structure at 4.45 GeV but not at the χc 0p and χc 2p thresholds would exclude the possibility of a pure kinematical effect.

  4. METHANE DE-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Bruce Bryan; Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2003-07-30

    During the current quarter, pilot-scale testing with the modified air nozzle version of the PC burner was completed with PRB coal at the Riley Power Inc. (RPI) test facility. A total of 8 different burner configurations were tested utilizing various burner air nozzle arrangements in place of the burner air channels. It was found that with the arrangements tested, a stable flame could not be maintained at coal feed rates above 100 lb/h. While it is felt that the air nozzle approach can ultimately be used effectively, in the interest of holding to the current project schedule it was decided to proceed with the balance of the project using the air channel design. The pilot-scale PC burner was therefore restored to the air-channel configuration and benchmark testing with PRB coal to confirmed previous operating results. A series of tests was then conducted with PRB and West Virginia caking coal to evaluate modifications to the gas combustor configuration and operation for improved performance with caking coal. Continuous operation was achieved with caking coal up to 50 lb/h vs. the full load target of 150 lb/h. Impingement and deposition of partially devolatilized coal occurred at various points within the combustor when the caking coal feed was increased above 50 lb/h. The 100 MMBtu/h commercial-scale prototype design was started with coal burner design input from both RPI and VTI. Based on typical burner installation layout considerations, it was that the preheat combustor should be oriented horizontally on the axial centerline of the coal burner. Accordingly, work was begun to relocate the pilot gas combustor to this orientation so that the pilot results with caking coal will be directly applicable to the preferred 100 MMBtu design. Inspection and repair of the 100 MMBtu/h Coal Burner Test Facility (CBTF) was initiated by RPI and as of 6/30, this activity was 70% complete.

  5. RADON AND PROGENY ALPHA-PARTICLE ENERGY ANALYSIS USING NUCLEAR TRACK METHODOLOGY

    SciTech Connect

    Espinosa Garcia, Guillermo; Golzarri y Moreno, Dr. Jose Ignacio; Bogard, James S

    2008-01-01

    A preliminary procedure for alpha energy analysis of radon and progeny using Nuclear Track Methodology (NTM) is described in this paper. The method is based on the relationship between alpha-particle energies deposited in polycarbonate material (CR-39) and the track size developed after a well-established chemical etching process. Track geometry, defined by parameters such as major or minor diameters, track area and overall track length, is shown to correlate with alpha-particle energy over the range 6.00 MeV (218Po) to 7.69 MeV (214Po). Track features are measured and the data analyzed automatically using a digital imaging system and commercial PC software. Examination of particle track diameters in CR-39 exposed to environmental radon reveals a multi-modal distribution. Locations of the maxima in this distribution are highly correlated with alpha particle energies of radon daughters, and the distributions are sufficiently resolved to identify the radioisotopes. This method can be useful for estimating the radiation dose from indoor exposure to radon and its progeny.

  6. REC Tracking Systems Design Guide

    SciTech Connect

    Meredith Wingate

    2004-02-03

    OAK-B135 The Design Guide is presented in three parts. Section II describes the need for REC tracking, the two principal tracking methods available, and, in simple terms, the operation of certificate-based systems. Section III presents the major issues in the design of certificate-based tracking systems and discusses the advantages and disadvantages of alternative solutions. Finally, Section IV offers design principles or recommendations for most of these issues.

  7. Electrochemical fabrication and optoelectronic properties of hybrid heterostructure of CuPc/porous GaN

    NASA Astrophysics Data System (ADS)

    Peng, Fei; Qin, Shuang-Jiao; Hu, Li-Feng; Wang, Juan-Ye; Yang, Jia-Mei; Chen, Xue-Qing; Pan, Ge-Bo

    2016-05-01

    A new hybrid heterostructure of p-type copper phthalocyanine (CuPc) and n-type porous GaN (PGaN) has been fabricated by electrophoretic deposition. The influence of CuPc concentration, electric field intensity, and deposition time on the growth of CuPc film has been explored. The as-prepared CuPc films are made of numerous nanorods. The X-ray diffraction (XRD) spectra revealed that the CuPc films are the β phase and amorphous type on pristine and porous GaN, respectively. Moreover, the prototype devices were fabricated on the basis of the CuPc/PGaN heterostructures. The devices exhibited excellent photodetector performance under ultraviolet (UV) light illumination.

  8. A dynamic model for PC4 coactivator function in RNA polymerase II transcription

    PubMed Central

    Malik, Sohail; Guermah, Mohamed; Roeder, Robert G.

    1998-01-01

    Human positive cofactor (PC4) acts as a general coactivator for activator-dependent transcription by RNA polymerase II. Here we show that PC4 coactivator function, in contrast to basal (activator-independent) transcription, is dependent both on TATA binding protein (TBP)-associated factors (TAFs) in TFIID and on TFIIH. Surprisingly, PC4 strongly represses transcription initiation by minimal preinitiation complexes in the absence of TAFs and TFIIH, while simultaneously promoting the formation of these complexes. Furthermore, TFIIH and TAFII250, the largest subunit of TFIID, can both phosphorylate PC4. These results provide evidence for an inactive, PC4-induced intermediate in preinitiation complex assembly and point to TFIIH and TAF requirements for its progression into a functional preinitiation complex. Thus PC4 coactivator activity is realized in a stepwise series of events reminiscent of prokaryotic activation pathways involving conversion of inactive RNA polymerase-promoter complexes to an initiation-competent state. PMID:9482861

  9. Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway

    NASA Astrophysics Data System (ADS)

    Zeng, Chuan-Chuan; Zhang, Cheng; Yao, Jun-Hua; Lai, Shang-Hai; Han, Bing-Jie; Li, Wei; Tang, Bing; Wan, Dan; Liu, Yun-Jun

    2016-11-01

    In this article, the in vitro cytotoxicity of platycodin D was evaluated in human PC-12, SGC-7901, BEL-7402, HeLa and A549 cancer cell lines. PC-12 cells were sensitive to platycodin D treatment, with an IC50 value of 13.5 ± 1.2 μM. Morphological and comet assays showed that platycodin D effectively induced apoptosis in PC-12 cells. Platycodin D increased the levels of reactive oxygen species (ROS) and induced a decrease in mitochondrial membrane potential. Platycodin D induced cell cycle arrest at the G0/G1 phase in the PC-12 cell line. Platycodin D can induce autophagy. In addition, platycodin D can down-regulate the expression of Bcl-2 and Bcl-x, and up-regulate the levels of Bid protein in the PC-12 cells. The results demonstrated that platycodin D induced PC-12 cell apoptosis through a ROS-mediated mitochondrial dysfunction pathway.

  10. Solar Array Tracking Control

    1995-06-22

    SolarTrak used in conjunction with various versions of 68HC11-based SolarTrack hardware boards provides control system for one or two axis solar tracking arrays. Sun position is computed from stored position data and time from an on-board clock/calendar chip. Position feedback can be by one or two offset motor turn counter square wave signals per axis, or by a position potentiometer. A limit of 256 counts resolution is imposed by the on-board analog to digital (A/D)more » convertor. Control is provided for one or two motors. Numerous options are provided to customize the controller for specific applications. Some options are imposed at compile time, some are setable during operation. Software and hardware board designs are provided for Control Board and separate User Interface Board that accesses and displays variables from Control Board. Controller can be used with range of sensor options ranging from a single turn count sensor per motor to systems using dual turn-count sensors, limit sensors, and a zero reference sensor. Dual axis trackers oriented azimuth elevation, east west, north south, or polar declination can be controlled. Misalignments from these orientations can also be accommodated. The software performs a coordinate transformation using six parameters to compute sun position in misaligned coordinates of the tracker. Parameters account for tilt of tracker in two directions, rotation about each axis, and gear ration errors in each axis. The software can even measure and compute these prameters during an initial setup period if current from a sun position sensor or output from photovoltaic array is available as an anlog voltage to the control board''s A/D port. Wind or emergency stow to aj present position is available triggered by digital or analog signals. Night stow is also available. Tracking dead band is adjustable from narrow to wide. Numerous features of the hardware and software conserve energy for use with battery powered systems.« less

  11. Eye Tracking Outcomes in Tobacco Control Regulation and Communication: A Systematic Review

    PubMed Central

    Meernik, Clare; Jarman, Kristen; Wright, Sarah Towner; Klein, Elizabeth G.; Goldstein, Adam O.; Ranney, Leah

    2016-01-01

    Objective In this paper we synthesize the evidence from eye tracking research in tobacco control to inform tobacco regulatory strategies and tobacco communication campaigns. Methods We systematically searched 11 databases for studies that reported eye tracking outcomes in regards to tobacco regulation and communication. Two coders independently reviewed studies for inclusion and abstracted study characteristics and findings. Results Eighteen studies met full criteria for inclusion. Eye tracking studies on health warnings consistently showed these warnings often were ignored, though eye tracking demonstrated that novel warnings, graphic warnings, and plain packaging can increase attention toward warnings. Eye tracking also revealed that greater visual attention to warnings on advertisements and packages consistently was associated with cognitive processing as measured by warning recall. Conclusions Eye tracking is a valid indicator of attention, cognitive processing, and memory. The use of this technology in tobacco control research complements existing methods in tobacco regulatory and communication science; it also can be used to examine the effects of health warnings and other tobacco product communications on consumer behavior in experimental settings prior to the implementation of novel health communication policies. However, the utility of eye tracking will be enhanced by the standardization of methodology and reporting metrics. PMID:27668270

  12. Solar tracking system

    SciTech Connect

    White, P.R.; Scott, D.R.

    1981-04-01

    A solar tracker for a solar collector is described in detail. The collector is angularly oriented by a motor wherein the outputs of two side-by-side photodetectors are discriminated as to three ranges: a first corresponding to a low light or darkness condition a second corresponding to light intensity lying in an intermediate range and a third corresponding to light above an intermediate range, direct sunlight. The first output drives the motor to a selected maximum easterly angular position the second enables the motor to be driven westerly at the Earth rotational rate and the third output, the separate outputs of the two photodetectors, differentially controls the direction of rotation of the motor to effect actual tracking of the Sun. Official Gazette of the U.S. Patent and Trademark Office

  13. Intrinsic Feature Motion Tracking

    SciTech Connect

    Goddard, Jr., James S.

    2013-03-19

    Subject motion during 3D medical scanning can cause blurring and artifacts in the 3D images resulting in either rescans or poor diagnosis. Anesthesia or physical restraints may be used to eliminate motion but are undesirable and can affect results. This software measures the six degree of freedom 3D motion of the subject during the scan under a rigidity assumption using only the intrinsic features present on the subject area being monitored. This movement over time can then be used to correct the scan data removing the blur and artifacts. The software acquires images from external cameras or images stored on disk for processing. The images are from two or three calibrated cameras in a stereo arrangement. Algorithms extract and track the features over time and calculate position and orientation changes relative to an initial position. Output is the 3D position and orientation change measured at each image.

  14. Intrinsic Feature Motion Tracking

    2013-03-19

    Subject motion during 3D medical scanning can cause blurring and artifacts in the 3D images resulting in either rescans or poor diagnosis. Anesthesia or physical restraints may be used to eliminate motion but are undesirable and can affect results. This software measures the six degree of freedom 3D motion of the subject during the scan under a rigidity assumption using only the intrinsic features present on the subject area being monitored. This movement over timemore » can then be used to correct the scan data removing the blur and artifacts. The software acquires images from external cameras or images stored on disk for processing. The images are from two or three calibrated cameras in a stereo arrangement. Algorithms extract and track the features over time and calculate position and orientation changes relative to an initial position. Output is the 3D position and orientation change measured at each image.« less

  15. Microencapsulated cell tracking

    PubMed Central

    Arifin, Dian R.; Kedziorek, Dorota A.; Fu, Yingli; Chan, Kannie W. Y.; McMahon, Michael T.; Weiss, Clifford R.; Kraitchman, Dara L.; Bulte, Jeff W. M.

    2013-01-01

    Microencapsulation of therapeutic cells has been widely pursued to achieve cellular immunoprotection following transplantation. Initial clinical studies have shown the potential of microencapsulation using semi-permeable alginate layers, but much needs to be learned about the optimal delivery route, in vivo pattern of engraftment, and microcapsule stability over time. In parallel with noninvasive imaging techniques for ‘naked’ (i.e. unencapsulated) cell tracking, microcapsules have now been endowed with contrast agents that can be visualized by 1H MRI, 19F MRI, X-ray/computed tomography and ultrasound imaging. By placing the contrast agent formulation in the extracellular space of the hydrogel, large amounts of contrast agents can be incorporated with negligible toxicity. This has led to a new generation of imaging biomaterials that can render cells visible with multiple imaging modalities. PMID:23225358

  16. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells

    PubMed Central

    Kim, Jin-Man; Kim, Kyunghwan; Schmidt, Thomas; Punj, Vasu; Tucker, Haley; Rice, Judd C.; Ulmer, Tobias S.; An, Woojin

    2015-01-01

    SET and MYND domain containing protein 3 (SMYD3) is a histone methyltransferase, which has been implicated in cell growth and cancer pathogenesis. Increasing evidence suggests that SMYD3 can influence distinct oncogenic processes by acting as a gene-specific transcriptional regulator. However, the mechanistic aspects of SMYD3 transactivation and whether SMYD3 acts in concert with other transcription modulators remain unclear. Here, we show that SMYD3 interacts with the human positive coactivator 4 (PC4) and that such interaction potentiates a group of genes whose expression is linked to cell proliferation and invasion. SMYD3 cooperates functionally with PC4, because PC4 depletion results in the loss of SMYD3-mediated H3K4me3 and target gene expression. Individual depletion of SMYD3 and PC4 diminishes the recruitment of both SMYD3 and PC4, indicating that SMYD3 and PC4 localize at target genes in a mutually dependent manner. Artificial tethering of a SMYD3 mutant incapable of binding to its cognate elements and interacting with PC4 to target genes is sufficient for achieving an active transcriptional state in SMYD3-deficient cells. These observations suggest that PC4 contributes to SMYD3-mediated transactivation primarily by stabilizing SMYD3 occupancy at target genes. Together, these studies define expanded roles for SMYD3 and PC4 in gene regulation and provide an unprecedented documentation of their cooperative functions in stimulating oncogenic transcription. PMID:26350217

  17. Intermixing behaviors of PCBM with CuPc on Au(1 1 1) surface

    NASA Astrophysics Data System (ADS)

    Masui, Akane; Sakaue, Hiroyuki; Takahagi, Takayuki; Suzuki, Hitoshi

    2016-09-01

    The behavior of phenyl-C61-butyric acid methyl ester (PCBM) and copper-phthalocyanine (CuPc) on a Au(1 1 1) surface was investigated using scanning tunneling microscopy (STM). When CuPc was deposited in addition to PCBM it entered and disturbed the regularly spaced double row superstructure of the PCBM molecules. PCBM intermixed with CuPc to form a new square shaped superstructure that consisted of six to eight PCBM molecules with a CuPc molecule in its center. The intermixing of these materials that was observed indicated that they possessed an attractive interaction.

  18. Effect of K doping on CuPc: C{sub 60} heterojunctions

    SciTech Connect

    Cheng, Chiu-Ping; Chen, Wen-Yen; Wei, Ching-Hsuan; Pi, Tun-Wen

    2011-12-01

    Here, the electronic properties of K-doped copper phthalocyanine (CuPc): C{sub 60} heterojunctions are studied via synchrotron-radiation photoemission. The K-doped heterointerfaces were obtained by means of C{sub 60} on K{sub 1.5}CuPc and CuPc on K{sub 3}C{sub 60}. The photoelectron spectra show that the potassium prefers to combine with C{sub 60}. At the C{sub 60}/K{sub 1.5}CuPc interface, the K diffuses and transfers negative charge into the C{sub 60} overlayer, while no strong chemical reaction could be found at the CuPc/K{sub 3}C{sub 60} interface. A significant shift of the vacuum level was observed in both cases, which was caused by the charge transfer for the C{sub 60}/K{sub 1.5}CuPc and by the induced density of interface states (IDIS) dipole for the CuPc/K{sub 3}C{sub 60}. The energy level diagrams show that using C{sub 60} adsorption on a K-doped CuPc film is good for the improvement of photovoltaic devices. However, the inverse process, that of CuPc on a K-doped C{sub 60}, is unfavorable for the photovoltaic effect.

  19. Probing the ultrafast electron transfer at the CuPc/Au(111) interface

    SciTech Connect

    Chen Wei; Wang Li; Qi Dongchen; Chen Shi; Gao Xingyu; Wee, Andrew Thye Shen

    2006-05-01

    Core-hole clock spectroscopy and near-edge x-ray-absorption fine structure measurements have been used to investigate the ultrafast electron transfer dynamics at the Copper(II) phthalocyanine (CuPc)/Au(111) interface. It was found that the strong electronic coupling between the first layer of CuPc molecules and Au(111) substrate favors ultrafast electron transfer from the lowest unoccupied molecular orbital of the CuPc molecules to the conduction band of Au(111) in the time scale of {approx}6 fs. In contrast, the intermolecular electron transfer within multilayers of CuPc molecules via the weak van der Waals interaction was much slower.

  20. PC based PLCs and ethernet based fieldbus: the new standard platform for future VLT instrument control

    NASA Astrophysics Data System (ADS)

    Kiekebusch, Mario J.; Lucuix, Christian; Erm, Toomas M.; Chiozzi, Gianluca; Zamparelli, Michele; Kern, Lothar; Brast, Roland; Pirani, Werther; Reiss, Roland; Popovic, Dan; Knudstrup, Jens; Duchateau, Michel; Sandrock, Stefan; Di Lieto, Nicola

    2014-07-01

    ESO is currently in the final phase of the standardization process for PC-based Programmable Logical Controllers (PLCs) as the new platform for the development of control systems for future VLT/VLTI instruments. The standard solution used until now consists of a Local Control Unit (LCU), a VME-based system having a CPU and commercial and proprietary boards. This system includes several layers of software and many thousands of lines of code developed and maintained in house. LCUs have been used for several years as the interface to control instrument functions but now are being replaced by commercial off-the-shelf (COTS) systems based on BECKHOFF Embedded PCs and the EtherCAT fieldbus. ESO is working on the completion of the software framework that enables a seamless integration into the VLT control system in order to be ready to support upcoming instruments like ESPRESSO and ERIS, that will be the first fully VLT compliant instruments using the new standard. The technology evaluation and standardization process has been a long and combined effort of various engineering disciplines like electronics, control and software, working together to define a solution that meets the requirements and minimizes the impact on the observatory operations and maintenance. This paper presents the challenges of the standardization process and the steps involved in such a change. It provides a technical overview of how industrial standards like EtherCAT, OPC-UA, PLCOpen MC and TwinCAT can be used to replace LCU features in various areas like software engineering and programming languages, motion control, time synchronization and astronomical tracking.

  1. Geo Issue Tracking System

    NASA Astrophysics Data System (ADS)

    Khakpour, Mohammad; Paulik, Christoph; Hahn, Sebastian

    2016-04-01

    Communication about remote sensing data quality between data providers and users as well as between the users is often difficult. The users have a hard time figuring out if a product has known problems over their region of interest and data providers have to spend a lot of effort to make this information available, if it exists. Scientific publications are one tool for communicating with the users base but they are static and mostly one way. As a data provider it is also often difficult to make feedback, received from users, available to the complete user base. The Geo Issue Tracking System (GeoITS) is an Open Source Web Application which has been developed to mitigate these problems. GeoITS combines a mapping interface (Google Maps) with a simple wiki platform. It allows users to give region specific feedback on a remote sensing product by drawing a polygon on the map and describing the problems they had using the remote sensing product in this area. These geolocated wiki entries are then viewable by other users as well as the data providers which can modify and extend the entries. In this way the conversations between the users and the data provider are no longer hidden in e.g. emails but open for all users of the dataset. This new kind of communication platform can enable better cooperation between users and data providers. It will also provide data providers with the ability to track problems their dataset might have in certain areas and resolve them with new product releases. The source code is available via http://github.com/TUW-GEO/geoits_dev A running instance can be tried at https://geoits.herokuapp.com/

  2. Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.

    PubMed Central

    Lotz, M; Rosen, F; McCabe, G; Quach, J; Blanco, F; Dudler, J; Solan, J; Goding, J; Seegmiller, J E; Terkeltaub, R

    1995-01-01

    Articular cartilage chondrocytes have the unique ability to elaborate large amounts of extracellular pyrophosphate (PPi), and transforming growth factor beta (TGF beta) appears singular among cartilage regulatory factors in stimulating PPi production. TGF beta caused a time and dose-dependent increase in intracellular and extracellular PPi in human articular chondrocyte cultures. TGF beta and interleukin 1 beta (IL-1 beta) antagonistically regulate certain chondrocyte functions. IL-1 beta profoundly inhibited basal and TGF beta-induced PPi elaboration. To address mechanisms involved with the regulation of PPi synthesis by IL-1 beta and TGF beta, we analyzed the activity of the PPi-generating enzyme NTP pyrophosphohydrolase (NTPPPH) and the PPi-hydrolyzing enzyme alkaline phosphatase. Human chondrocyte NTPPPH activity was largely attributable to plasma cell membrane glycoprotein 1, PC-1. Furthermore, TGF beta induced comparable increases in the activity of extracellular PPi, intracellular PPi, and cellular NTPPPH and in the levels of PC-1 protein and mRNA in chondrocytes as well as a decrease in alkaline phosphatase. All of these TGF beta-induced responses were completely blocked by IL-1 beta. Thus, IL-1 beta may be an important regulator of mineralization in chondrocytes by inhibiting TGF beta-induced PPi production and PC-1 expression. Images Fig. 4 Fig. 5 PMID:7479785

  3. Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments.

    PubMed Central

    Wouters, S; Leruth, M; Decroly, E; Vandenbranden, M; Creemers, J W; van de Loo, J W; Ruysschaert, J M; Courtoy, P J

    1998-01-01

    The intracellular compartmentalization in rat liver of the membrane-associated convertases furin and proprotein convertase 7 (PC7)/lymphoma PC (LPC) was investigated by analytical subcellular fractionation. In control animals, both enzymes were found to localize in fractions depleted of endoplasmic reticulum, cis-Golgi and lysosomal markers, but to co-distribute with the Golgi marker galactosyltransferase and the trans-Golgi network (TGN) marker TGN38. After overloading Golgi-derived vesicles with very-low-density lipoproteins (VLDL) by feeding rats with ethanol, the distribution of PC7/LPC was shifted markedly towards lower densities, in contrast with those of furin and the TGN marker. This provides support for the TGN localization of endogenously expressed furin and indicates that, at steady state, a considerable proportion of PC7/LPC may be associated with vesicles derived from the TGN. PMID:9820806

  4. Statistical study of the ULF Pc4-Pc5 range fluctuations in the vicinity of Earth's magnetopause and correlation with the Low Latitude Boundary Layer thickness

    NASA Astrophysics Data System (ADS)

    Nykyri, K.; Dimmock, A. P.

    2016-07-01

    The main generation mechanisms for the Earth's Low Latitude Boundary Layer (LLBL) are considered to be magnetic reconnection, viscous interactions such as Kelvin-Helmholtz instability and associated plasma mixing and diffusion. We have performed a statistical study of the Ultra Low Frequency (ULF) fluctuation power at the Pc4-Pc5 range using ≈6 years of THEMIS measurements of the plasma velocity and magnetic field. The results reveal a clear dawn-dusk asymmetry showing that the fluctuation power is typically more enhanced in the vicinity of the magnetopause downstream of the quasi-parallel shock. The statistical study of the Vx-component of the plasma velocity indicates that the LLBL is also thicker on the dawn-sector. These results may suggest that the physical mechanisms that provide power in the Pc4-Pc5 range are more effective on the dawn-sector and provide a means for a more effective LLBL generation.

  5. Toxicogenomics in regulatory ecotoxicology

    USGS Publications Warehouse

    Ankley, Gerald T.; Daston, George P.; Degitz, Sigmund J.; Denslow, Nancy D.; Hoke, Robert A.; Kennedy, Sean W.; Miracle, Ann L.; Perkins, Edward J.; Snape, Jason; Tillitt, Donald E.; Tyler, Charles R.; Versteeg, Donald

    2006-01-01

    Recently, we have witnessed an explosion of different genomic approaches that, through a combination of advanced biological, instrumental, and bioinformatic techniques, can yield a previously unparalleled amount of data concerning the molecular and biochemical status of organisms. Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research has become a rapidly growing topical area in multiple biological disciplines. Since 1999, when the term “toxicogenomics” was coined to describe the application of genomics to toxicology (1), a rapid increase in publications on the topic has occurred (Figure 1). The potential utility of toxicogenomics in toxicological research and regulatory activities has been the subject of scientific discussions and, as with any new technology, has evoked a wide range of opinion (2–6). VIEWPOINT © 2006 american chemical Society july 1, 2006 / EnvironmEntal SciEncE & tEchnology n 4055 The purpose of this feature article is to consider the roles of toxicogenomics in the field of regulatory ecotoxicology, explore current limitations in the science and practice of genomics, and propose possible avenues to approach and resolve some of the major challenges. A significant amount of input to our analysis came from a workshop sponsored by the Society of Environmental Toxicology and Chemistry (SETAC) in Pellston, Mich., in September 2005. A complete list of names and affiliations of the experts participating in that workshop is provided online in Table 1 of the Supporting Information for this paper.

  6. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Bruce Bryan; Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2003-09-30

    During the current quarter, pilot-scale testing with the modified air nozzle version of the PC burner was completed with PRB coal at the Riley Power Inc. (RPI) test facility. A total of 8 different burner configurations were tested utilizing various burner air nozzle arrangements in place of the burner air channels. It was found that with the arrangements tested, a stable flame could not be maintained at coal feed rates above 100 lb/h. While it is felt that the air nozzle approach can ultimately be used effectively, in the interest of holding to the current project schedule it was decided to proceed with the balance of the project using the air channel design. The pilot-scale PC burner was therefore restored to the air-channel configuration and benchmark testing with PRB coal to confirmed previous operating results. A series of tests was then conducted with PRB and West Virginia caking coal to evaluate modifications to the gas combustor configuration and operation for improved performance with caking coal. Continuous operation was achieved with caking coal up to 50 lb/h vs. the full load target of 150 lb/h. Impingement and deposition of partially devolatilized coal occurred at various points within the combustor when the caking coal feed was increased above 50 lb/h. The 100 MMBtu/h commercial-scale prototype design was continued with coal burner design input from both RPI and VTI. Based on typical burner installation layout considerations, it was decided that the preheat combustor should be oriented horizontally on the axial centerline of the coal burner. Accordingly, the pilot gas combustor was changed to this orientation so that the pilot results with caking coal will be directly applicable to the preferred 100 MMBtu design. Testing with caking coal in the horizontal pilot combustor achieved feed rates up to 126 lb/h, although some deposition and LOI issues remain. Several promising approaches to further improve operation with caking coal were identified. NOx

  7. Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells.

    PubMed Central

    Jean, F; Basak, A; Rondeau, N; Benjannet, S; Hendy, G N; Seidah, N G; Chrétien, M; Lazure, C

    1993-01-01

    Prohormone convertase-1 (PC1), an endopeptidase that is structurally related to the yeast subtilisin-like Kex2 gene product, has been proposed to be involved in mammalian tissue-specific prohormone processing at pairs of basic residues. To better study this enzyme, a rat somatomammotroph cell line, GH4C1, was infected with vaccinia virus recombinants of murine PC1 (mPC1) and human PC1 (hPC1). An enzymically active form of each protein was secreted into the cell medium and partially purified by anion-exchange chromatography. The 80-85 kDa enzyme was shown to be Ca(2+)-dependent and exhibited a pH optimum of 6.0 when assayed against a synthetic fluorogenic substrate, acetyl-Arg-Ser-Lys-Arg-4-methylcoumaryl-1-amide. mPC1 and hPC1 displayed identical cleavage selectivity towards a number of fluorogenic substrates, and those incorporating an Arg at the P4 site were most favoured. Synthetic peptides, encompassing the junction between the putative pro-region and the active enzyme, and between the pro-region and the biologically active parathyroid hormone, were shown to be recognized and cleaved specifically at the pair of basic residues by both enzymes. Group-specific proteinase inhibitors such as metal ion chelators and p-hydroxymercuribenzoate, but not phenylmethanesulphonyl fluoride and pepstatin, strongly inhibit the PC1-associated activity. In addition, it is shown that an enzyme activity displaying identical properties is present in the cell medium of uninfected corticotroph AtT-20 cells and that its level is increased following stimulation of secretion by the secretagogue 8-bromo cyclic AMP. PMID:8318017

  8. SRNL Tagging and Tracking Video

    ScienceCinema

    None

    2016-07-12

    SRNL generates a next generation satellite base tracking system. The tagging and tracking system can work in remote wilderness areas, inside buildings, underground and other areas not well served by traditional GPS. It’s a perfect response to customer needs and market demand.

  9. CONTRACT ADMINISTRATIVE TRACKING SYSTEM (CATS)

    EPA Science Inventory

    The Contract Administrative Tracking System (CATS) was developed in response to an ORD NHEERL, Mid-Continent Ecology Division (MED)-recognized need for an automated tracking and retrieval system for Cost Reimbursable Level of Effort (CR/LOE) Contracts. CATS is an Oracle-based app...

  10. Airborne ballistic camera tracking systems

    NASA Technical Reports Server (NTRS)

    Redish, W. L.

    1976-01-01

    An operational airborne ballistic camera tracking system was tested for operational and data reduction feasibility. The acquisition and data processing requirements of the system are discussed. Suggestions for future improvements are also noted. A description of the data reduction mathematics is outlined. Results from a successful reentry test mission are tabulated. The test mission indicated that airborne ballistic camera tracking systems are feasible.

  11. Making Sense of Dinosaur Tracks

    ERIC Educational Resources Information Center

    MacKenzie, Ann Haley; McDowell, Brian

    2012-01-01

    What do paleontologists, dinosaur tracks, and the nature of science have in common? They're combined here in an inquiry activity where students use methods of observation and inference to devise evidence-based explanations for the data they collect about dinosaur tracks, much like the methods used by paleontologists. Students then debate the…

  12. Buyer's Guide for Track Construction.

    ERIC Educational Resources Information Center

    United States Tennis Court & Track Builders Association.

    This buyers guide provides information on needs assessment, buying options, and decision making tips when acquiring a new school athletic track. Among the topics covered are developing a budget, choosing a site selection, choosing a track surface, developing working specifications, and selecting a contractor. Also explored is the question of…

  13. COCOA: tracking in aerial imagery

    NASA Astrophysics Data System (ADS)

    Ali, Saad; Shah, Mubarak

    2006-05-01

    Unmanned Aerial Vehicles (UAVs) are becoming a core intelligence asset for reconnaissance, surveillance and target tracking in urban and battlefield settings. In order to achieve the goal of automated tracking of objects in UAV videos we have developed a system called COCOA. It processes the video stream through number of stages. At first stage platform motion compensation is performed. Moving object detection is performed to detect the regions of interest from which object contours are extracted by performing a level set based segmentation. Finally blob based tracking is performed for each detected object. Global tracks are generated which are used for higher level processing. COCOA is customizable to different sensor resolutions and is capable of tracking targets as small as 100 pixels. It works seamlessly for both visible and thermal imaging modes. The system is implemented in Matlab and works in a batch mode.

  14. 49 CFR 213.331 - Track surface.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Track surface. 213.331 Section 213.331... Track surface. (a) For a single deviation in track surface, each owner of the track to which this subpart applies shall maintain the surface of its track within the limits prescribed in the...

  15. Low-voltage electroosmotic pumps fabricated from track-etched polymer membranes.

    PubMed

    Wang, Ceming; Wang, Lin; Zhu, Xiaorui; Wang, Yugang; Xue, Jianming

    2012-05-01

    Track-etched polymer membranes are used to realize low-voltage electroosmotic (EO) pumps. The nanopores in polycarbonate (PC) and polyethylene terephthalate (PET) membranes were fabricated by the track-etching technique, the pore diameter was controlled in the range of 100 to 250 nm by adjusting the etching time. The results show that these EO pumps can provide high flow rates at low applied voltages (2-5 V). The maximum normalized flow rate is as high as 0.12 ml min(-1) V(-1) cm(-2), which is comparable to the best values of previously demonstrated EO pumps. We attribute this high performance to the unique properties of the track-etched nanopores in the membranes. PMID:22441654

  16. Indexes of large genome collections on a PC.

    PubMed

    Danek, Agnieszka; Deorowicz, Sebastian; Grabowski, Szymon

    2014-01-01

    The availability of thousands of individual genomes of one species should boost rapid progress in personalized medicine or understanding of the interaction between genotype and phenotype, to name a few applications. A key operation useful in such analyses is aligning sequencing reads against a collection of genomes, which is costly with the use of existing algorithms due to their large memory requirements. We present MuGI, Multiple Genome Index, which reports all occurrences of a given pattern, in exact and approximate matching model, against a collection of thousand(s) genomes. Its unique feature is the small index size, which is customisable. It fits in a standard computer with 16-32 GB, or even 8 GB, of RAM, for the 1000GP collection of 1092 diploid human genomes. The solution is also fast. For example, the exact matching queries (of average length 150 bp) are handled in average time of 39 µs and with up to 3 mismatches in 373 µs on the test PC with the index size of 13.4 GB. For a smaller index, occupying 7.4 GB in memory, the respective times grow to 76 µs and 917 µs. Software is available at http://sun.aei.polsl.pl/mugi under a free license. Data S1 is available at PLOS One online. PMID:25289699

  17. Large-scale coordinated observations of Pc5 pulsation events

    NASA Astrophysics Data System (ADS)

    Mtumela, Zolile; Walker, Anthony D. M.; Stephenson, Judy A. E.; Kosch, Michael J.

    2016-09-01

    HF (high-frequency) radars belonging to SuperDARN (Super Dual Auroral Radar Network) receive backscatter over substantial fields of view which, when combined, allow for simultaneous returns over extensive regions of the polar caps and midlatitudes. This makes them ideal instruments for the observation of pulsations in the Pc5 (1-5 mHz) frequency band. Relatively few pulsation events observed by multiple radars have been reported in the literature. Here we describe observations of three such events which extend over more than 120° of magnetic longitude in the Northern Hemisphere and one of which is also detected in the Southern Hemisphere. All three events show characteristics of field line resonances. In one case the pulsation has also been observed by magnetometers under or near the radar fields of view. The extensive longitudinal coverage allows accurate determination of azimuthal wave numbers. These are at the upper end of the lower values associated with external sources such as those in the solar wind. Such sources imply antisunward flow. However, the azimuthal wave number is negative, implying westward propagation at magnetic local times on both sides of noon, as would be expected from drift-bounce resonance with positive particles. Quiet conditions and a very low ring current during the events argue against this. The identification of the source of pulsations from a number of different mechanisms remains a problem of interest.

  18. Synchronization of motor controller and PC system clocks

    NASA Astrophysics Data System (ADS)

    Kittmann, Frank; Bertram, Thomas; Briegel, Florian; Mohr, Lars; Berwein, Jürgen

    2010-07-01

    The power of the Large Binocular Telescope (LBT) with its two 8.4m primary mirrors sharing a common mount will unfold its full potential with the LINC-NIRVANA (LN) instrument. LINC-NIRVANA is a German-Italian beam combiner for the LBT and will interfere the light from the two 8.4m mirrors of the LBT in Fizeau mode. More than 140 motors have to be handled by custom developed Motor Controllers (MoCons). One important feature of the MoCon is the support of externally computed trajectories. Motion profiles provide information on the movement of the motor along a defined path over a certain period of time. Such profiles can be uploaded to the MoCon over Ethernet and can be started at a specific time. For field derotation it is critical that the derotation trajectories are executed with a very precise relative and absolute timing. This raises the problem of the synchronization of the MoCon internal clock with the system time of the servers that are hosting LINCNIRVANA's Instrument Control Software. The MoCon time should be known by the servers with an uncertainty of few milliseconds in order to match the start time of the motion profile and the field rotation trajectory. In this paper we will discuss how to synchronize the MoCon internal time and the PC system time.

  19. METHANE de-NOX for Utility PC Boilers

    SciTech Connect

    Bruce Bryan; Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2004-12-31

    Preparations for conducting large-scale combustion tests with caking bituminous coal continued during the start of this quarter. Major project accomplishments related to bituminous coal testing included: a CFD preheat model and evaluation, an update of the process flow diagram and a detailed preheat burner mechanical design (suitable for construction) for firing bituminous coal. Installation and testing of the 85 MMBtu/h bituminous coal preheating system was planned to take place before the end of December. Based on the inability to conduct testing in Riley's Commercial Burner Test Facility (CBTF) during freezing weather, a schedule review indicated required site work for testing bituminous coal at the CBTF could not be completed before freezing weather set in at the site. Further bituminous preheat modification work was put on hold and efforts turned to securing the test facility over the winter season. Bituminous coal tests are therefore delayed; April-May 2005 is earliest estimate of when testing can resume. A request for a time extension was submitted to DOE to extend the project through September 2005 to allow time to secure additional funding and complete the bituminous coal testing. Removal of the PRB PC Preheater from the CBTF burner deck was completed. Decommissioning of the CBTF for the winter was also completed.

  20. A PC-aided optical foetal heart rate detection system.

    PubMed

    Oweis, Rami J; As'ad, Hala; Aldarawsheh, Amany; Al-Khdeirat, Rawan; Lwissy, Kaldoun

    2014-01-01

    Safe monitoring of foetal heart rate is a valuable tool for the healthy evolution and wellbeing of both foetus and mother. This paper presents a non-invasive optical technique that allows for foetal heart rate detection using a photovoltaic infrared (IR) detector placed on the mother's abdomen. The system presented here consists of a photoplethysmography (PPG) circuit, abdomen circuit and a personal computer equipped with MATLAB. A near IR beam having a wavelength of 880 nm is transmitted through the mother's abdomen and foetal tissue. The received abdominal signal that conveys information pertaining to the mother and foetal heart rate is sensed by a low noise photodetector. The PC receives the signal through the National Instrumentation Data Acquisition Card (NIDAQ). After synchronous detection of the abdominal and finger PPG signals, the designed MATLAB-based software saves, analyses and extracts information related to the foetal heart rate. Extraction is carried out using recursive least squares adaptive filtration. Measurements on eight pregnant women with gestational periods ranging from 35-39 weeks were performed using the proposed system and CTG. Results show a correlation coefficient of 0.978 and a correlation confidence interval between 88-99.6%. The t test results in a p value of 0.034, which is less than 0.05. Low power, low cost, high signal-to-noise ratio, reduction of ambient light effect and ease of use are the main characteristics of the proposed system. PMID:24195701

  1. Stereotactic Neurosurgery Planning On A PC Based Workstation.

    NASA Astrophysics Data System (ADS)

    Peters, Terence M.; Clark, John A.; Pike, Gordon; Henri, Christopher J.; Collins, D. L.; Leksell, Dan; Jeppsson, Ola

    1989-05-01

    Stereotactic surgery requires knowledge of cerebral structures derived from more than one image source. We have developed a PC-AT based workstation which accepts patient images, made with the stereotactic frame in place, from CT, MRI and DSA modalities. Reference markers on the frame are identified in the images to establish the coordinate geometry for each modality. Target points may be identified on each image type and trajectories of probe paths to these points defined. Targets identified on one set of images may be transferred automatically to other images of the same patient, in order, for example, to guarantee a vascular free path of approach to a target point deep within the brain. To date several hundred patients have had stereotactic surgery performed on the basis of plans using this system. Procedures included biopsy and aspiration of lesions, implantation of electrodes for the recording of deep EEG signals, and radiosurgical techniques based on the use of a high energy linear accelerator. We present clinical examples of the use of this system in typical stereotactic neurosurgery procedures, address stereoscopic applications, and discuss the results of inter-modality tests to establish the accuracy of the technique.

  2. Nine new open clusters within 500 pc from the Sun

    NASA Astrophysics Data System (ADS)

    Röser, Siegfried; Schilbach, Elena; Goldman, Bertrand

    2016-10-01

    Aims: One of the results of the Milky Way Star Clusters (MWSC) survey was the detection of a slight under-density of old (ca. 1 Gyr) clusters within the nearest kilo-parsec from the Sun. This under-density may be due to an ineffectiveness in the detection of larger structures with lower surface brightness. We report on our attempts to reveal such clusters. Methods: We derived proper motions from a combination of Tycho-2 with URAT1, and obtained a mean precision of about 1.4 mas/yr per co-ordinate for 1.3 million stars north of -20° declination. We cut the sky into narrow proper motion slices and searched for spatial over-densities of stars in each slice. We then examined stars from over-densities in optical and near-infrared colour-magnitude diagrams to determine if they are compatible with isochrones of a cluster. We estimated the field star contamination using our data and the Besançon Galactic model. Results: We detected nine hitherto unknown open clusters in the vicinity of the Sun with ages between 70 Myr and 1 Gyr, and distances between 200 and 500 pc.

  3. Solid State Nuclear Track Detectors--I: Track Characteristics and Formation Mechanisms.

    ERIC Educational Resources Information Center

    Lal, Nand

    1991-01-01

    Heavily ionizing charged particles produce radiation damage tracks in a wide variety of insulating materials. The experimental properties of these tracks and track recorders are described. The mechanisms by which the tracks are produced are discussed. (Author/KR)

  4. 75 FR 79751 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ...--Definition and Administration (DFARS Case 2009-D038) 0750-AG58 297 Warranty Tracking of Serialized Items... manner similar to the domestic source restriction of the Buy American Act. Timetable: Action Date FR Cite NPRM 05/07/10 75 FR 25167 NPRM Comment Period End 07/06/10 Final Action 12/00/10 Regulatory...

  5. Comparison of CAP88 PC Ver. 3.0 and MAXDOSE dose assessment models involving co-located stack releases at the Savannah River site.

    PubMed

    Farfán, Eduardo; Jannik, G Timothy; Lee, Patricia; Powell, Aaron

    2013-08-01

    The Savannah River National Laboratory's Environmental Dosimetry Group performs dosimetry assessments for Savannah River Site (SRS) radionuclide air emissions utilizing the Clean Air Act Assessment Package-1988 (CAP88) code (CAP88 PC Ver. 3.0) and the MAXDOSE-SR Ver. 2011 code, which is an SRS-specific version of the Nuclear Regulatory Commission's MAXIGASP code. CAP88 PC and MAXDOSE-SR are used at SRS for demonstrating compliance with Environmental Protection Agency dose standards for radionuclide emissions to the atmosphere and Department of Energy Order 458.1 dose standards, respectively. During a routine comparison of these two assessment models, it was discovered that CAP88 PC Ver. 3.0 was not producing the expected results when using multiple co-located stacks in a single run. Specifically, if the stack heights are considered separately, the results for several radionuclides (but not all) differ from the combined run [i.e., 1 + 2 does not equal (1+2)]. Additionally, when two or more stack heights are considered in a run, the results depend on the order of the selected stack heights. For example, for a two stack-height run of 0 meter and 61 m input produces different results from a 61 m and 0 m input run. This study presents a comparison of CAP88 PC Ver. 3.0 and MAXDOSE-SR Ver. 2011 based on SRS input data and on two-stack release scenarios. The selected radionuclides for this study included gases/vapors (H, C, Kr, and I) and particulates (Sr, Cs, Pu, and Am) commonly encountered at SRS.

  6. Regulatory Considerations for Biosimilars

    PubMed Central

    Nellore, Ranjani

    2010-01-01

    Currently there is considerable interest in the legislative debate around generic biological drugs or “biosimilars” in the EU and US due to the large, lucrative market that it offers to the industry. While some countries have issued a few regulatory guidelines as well as product specific requirements, there is no general consensus as to a single, simple mechanism similar to the bioequivalence determination that leads to approval of generic small molecules all over the world. The inherent complex nature of the molecules, along with complicated manufacturing and analytical techniques to characterize them make it difficult to rely on a single human pharmacokinetic study for assurance of safety and efficacy. In general, the concept of comparability has been used for evaluation of the currently approved “similar” biological where a step by step assessment on the quality, preclinical and clinical aspects is made. In India, the focus is primarily on the availability and affordability of life-saving drugs. In this context every product needs to be evaluated on its own merit irrespective of the innovator brand. The formation of the National Biotechnology Regulatory Authority may provide a step in the right direction for regulation of these complex molecules. However, in order to have an efficient machinery for initial approval and ongoing oversight with a country-specific focus, cooperation with international authorities for granting approvals and continuous risk-benefit review is essential. Several steps are still needed for India to be perceived as a country that leads the world in providing quality biological products. PMID:21829775

  7. Regulatory Streamlining and Improvement

    SciTech Connect

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and Development: This area

  8. Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.

    PubMed

    Chen, Zhiwei; Yu, Yongfeng; Fu, Da; Li, Ziming; Niu, Xiaoming; Liao, Meilin; Lu, Shun

    2010-06-01

    Phosphatidylcholine-specific phospholipase C (PC-PLC) is the major enzyme in the Phosphatidylcholine (PC) cycle and is involved in many long-term cellular responses such as activation, proliferation, and differentiation events. Cell division cycle 20 homolog (Cdc20) is an essential cell-cycle regulator required for the completion of mitosis. Our previous studies identified the interaction between PC-PLC and Cdc20. Through the interaction, Cdc20 could mediate the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway (UPP). In this study, we found that PC-PLC might not be involved in cancer metastasis. Inhibition of PC-PLC by D609 could cause cell proliferation inhibition and apoptosis inhibition in CBRH-7919 cells. Inhibition of PC-PLC could also influence the cell cycle by arresting the cells in G1 phase, and Cdc20 might be involved in these processes. Taken together, in this report, we provided new evidence for the functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis in CBRH-7919 cells.

  9. Pc1 propagation in the ionopsheric duct: dispersion relation and source structure

    NASA Astrophysics Data System (ADS)

    Nomura, R.; Plaschke, F.; Narita, Y.; Glassmeier, K.; Fujita, S.; Mann, I. R.

    2013-12-01

    Pc1 geomagnetic pulsations (Pc1) observed on the ground at subauroral latitudes are signatures of ion cyclotron waves at frequencies between 0.2 and 5.0Hz in the inner magnetosphere. When the waves reach the ionosphere, they induce time-varying Pedersen and Hall currents that generate both Alfven and fast mode waves in the ionospheric duct. The fast mode waves propagate horizontally and are observed in distant areas at lower latitudes from the wave entrance region. Previous theoretical studies have shown attenuation rates, polarizations, and dispersion relations of those waves. So far no observational study found a Pc1 dispersion relation and compared with theoretical results. We have investigated wave vectors of Pc1 pulsations both with the 2D Wave Telescope technique and with the minimum variance analysis. We also have investigated the spatial power distribution of Pc1 pulsations. For our study, we used ground-based measurements of Pc1 pulsations from 27 May 2011, observed at 17 different stations of the Canadian magnetometer network CARISMA (www.carisma.ca). We identified the frequency-wave number relation that shows a behavior of fast mode waves. Furthermore, we found that the attenuation rates of Pc1 wave power are larger along the meridian than normal it, in contrast to theoretical results. The possible source structure of incident Alfven waves will be discussed using power distributions of Pc1 pulsations by considering both effects of attenuation and conversion to fast mode waves.

  10. Integrating a Single Tablet PC in Chemistry, Engineering, and Physics Courses

    ERIC Educational Resources Information Center

    Rogers, James W.; Cox, James R.

    2008-01-01

    A tablet PC is a versatile computer that combines the computing power of a notebook with the pen functionality of a PDA (Cox and Rogers 2005b). The authors adopted tablet PC technology in order to improve the process and product of the lecture format in their chemistry, engineering, and physics courses. In this high-tech model, a single tablet PC…

  11. USL/DBMS NASA/PC R and D project C programming standards

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Moreau, Dennis R.

    1984-01-01

    A set of programming standards intended to promote reliability, readability, and portability of C programs written for PC research and development projects is established. These standards must be adhered to except where reasons for deviation are clearly identified and approved by the PC team. Any approved deviation from these standards must also be clearly documented in the pertinent source code.

  12. State identification and tunable Kondo effect of MnPc on Ag(001)

    NASA Astrophysics Data System (ADS)

    Kügel, Jens; Karolak, Michael; Krönlein, Andreas; Senkpiel, Jacob; Hsu, Pin-Jui; Sangiovanni, Giorgio; Bode, Matthias

    2015-06-01

    We present a detailed investigation of spectroscopic features located at the central metal ion of MnPc (where Pc represents phthalocyanine) on Ag(001) by means of scanning tunneling spectroscopy (STS) and first-principles theory. STS data taken close to the Fermi level reveal an asymmetric feature that cannot be fitted with a single Fano function representing a one-channel Kondo effect. Instead, our data indicate the existence of a second superimposed feature. Two potential physical origins, a second Kondo channel related to the dx z /y z orbitals, and a spectral feature of the dz2 orbital itself, are discussed. A systematic experimental and theoretical comparison of MnPc with CoPc and FePc indicates that the second feature observed on MnPc is caused by the dz2 orbital. This conclusion is corroborated by STM-induced dehydrogenation experiments on FePc and MnPc which in both cases result in a gradual shift towards more positive binding energies and a narrowing of the Kondo resonance. Theoretical analysis reveals that the latter is caused by the reduced hybridization between the d orbital and the substrate. Spatially resolved differential conductivity maps taken close to the respective peak positions show that the intensity of both features is highest over the central Mn ion, thereby providing further evidence against a second Kondo channel originating from the dx z /y z orbital of the central Mn ion.

  13. DIFFERENTIAL MODULATION OF CATECHOLAMINES BY CHLOROTRIAZINE HERBICIDES IN PHEOCHROMOCYTOMA (PC12) CELLS IN VITRO

    EPA Science Inventory

    Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro.

    Das PC, McElroy WK, Cooper RL.

    Curriculum in Toxicology, University of North Carolina, Chapel Hill 27599, USA.

    Epidemiological, wildlife, and lab...

  14. Fluorescence of Pc 4 in U87 cells following photodynamic therapy

    NASA Astrophysics Data System (ADS)

    Varghai, Davood; Azizuddin, Kashif; Ahmad, Yusra; Oleinick, Nancy L.; Dean, David

    2007-02-01

    Introduction: Given the length of procedures and the brightness of operating room lights, there is concern that photosensitizers used to locate brain tumors and treat them with photodynamic therapy (PDT) may photobleach before they can be fully utilized. The phthalocyanine photosensitizer Pc 4 is resistant to photobleaching. In this study, we tested the hypothesis that exposure of Pc 4-loaded glioma cells to photoactivating light will result in continuing fluorescence of Pc 4. Methods: U87 human glioma cells were cultured in MEM with 5% penicillin/streptomycin, 5% sodium pyruvate, 10% fetal bovine serum, and 25 mM HEPES. These cultures were given 0 or 125 nM Pc 4, followed 2 hours later by three separate exposures of 200 J/cm2 of red light (λ max = 675 nm). Confocal fluorescence images were collected before and after each exposure. Results: Pc 4 fluorescence was localized to cytoplasmic membranes of the U87 glioma cells, as previously seen in other types of cells. After exposure to PDT, Pc 4 fluorescence was not reduced and even increased. Discussion: Pc 4 may be useful for the intra-operative detection of glioma by fluorescence and for PDT, since neither Pc 4 level nor its fluorescence is likely to decrease during exposure to operating room lights.

  15. 21 CFR 868.2500 - Cutaneous oxygen (PcO 2) monitor.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Cutaneous oxygen (PcO 2) monitor. 868.2500 Section 868.2500 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Monitoring Devices § 868.2500 Cutaneous oxygen (PcO...

  16. 21 CFR 868.2500 - Cutaneous oxygen (PcO 2) monitor.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Cutaneous oxygen (PcO 2) monitor. 868.2500 Section 868.2500 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Monitoring Devices § 868.2500 Cutaneous oxygen (PcO...

  17. Using a Tablet PC in the German Classroom to Enliven Teacher Input

    ERIC Educational Resources Information Center

    Van Orden, Stephen

    2006-01-01

    Providing students with lively, authentic comprehensible input is one of the most important tasks of introductory German teachers. Using a Tablet PC can enable teachers to improve the quality of the comprehensible input they provide their students. This article describes how integrating a Tablet PC into daily teaching processes allows classroom…

  18. Statistical study of propagation characteristics of Pc1 pearl structures using conjugate ground-satellite observations

    NASA Astrophysics Data System (ADS)

    Jun, C. W.; Shiokawa, K.; Takahashi, K.; Paulson, K. W.; Schofield, I.; Connors, M. G.; Poddelskiy, I.; Shevtsov, B.; Kletzing, C.; Wygant, J. R.

    2015-12-01

    We investigated statistical characteristics of pearl structures (amplitude modulation) of Pc1 pulsations using conjugate observations with the ground induction magnetometers located at Athabasca (ATH, L = 4.3) in Canada and Magadan (MGD, L = 2.7) in Russia and the Van Allen Probes (RBSP-A and B) satellites located in the inner magnetosphere for a 1-year period (August 2012 to August 2013). We consider a ground magnetometer and a satellite to be conjugate when the satellite footprint is located within 1000 km of the ground magnetometer. From a survey of data acquired during the conjunction periods, we found 42 pearl Pc1events. These events were classified into four categories: structured Pc1 waves observed at both locations (9 events), structured Pc1 waves observed only on the ground (22 events) or in space (0 events), and unstructured Pc1 waves at both locations (11 events). We describe the spatial and temporal distributions of Pc1 pearl structures and their dependence on geomagnetic conditions. We also compare the frequency, the power ratio between space and ground, and the polarization among the four categories of events. In addition, we verified the similarity of Pc1 pearl structures between ground and space observations in order to investigate propagation and polarization characteristics of Pc1 pearl structures from the magnetosphere to the ionosphere.

  19. Studies on Parylene C-caulked PDMS (pcPDMS) for low permeability required microfluidics applications.

    PubMed

    Lei, Yinhua; Liu, Yaoping; Wang, Wei; Wu, Wengang; Li, Zhihong

    2011-04-01

    This note introduced a complete fabrication strategy of Parylene C-caulked PDMS (pcPDMS) for low permeability required microfluidics applications. The bonding issue enrolled in the pcPDMS fabrication was solved based on careful surface analyses of the Parylene C caulked status in the PDMS matrix.

  20. Pathology of US Porcine Epidemic Diarrhea Virus Strain PC21A in Gnotobiotic Pigs

    PubMed Central

    Jung, Kwonil; Scheuer, Kelly A.; Lu, Zhongyan; Zhang, Yan; Saif, Linda J.

    2014-01-01

    To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. These findings confirm that strain PC21A is highly enteropathogenic. PMID:24795932

  1. Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

    PubMed Central

    Cesarini, Elisa; Mozzetta, Chiara; Marullo, Fabrizia; Gregoretti, Francesco; Gargiulo, Annagiusi; Columbaro, Marta; Cortesi, Alice; Antonelli, Laura; Di Pelino, Simona; Squarzoni, Stefano; Palacios, Daniela; Zippo, Alessio; Bodega, Beatrice; Oliva, Gennaro

    2015-01-01

    Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors—and how this cross talk influences physiological processes—is still unexplored. Key epigenetic regulators of development and differentiation are the Polycomb group (PcG) of proteins, organized in the nucleus as microscopically visible foci. Here, we show that lamin A/C is evolutionarily required for correct PcG protein nuclear compartmentalization. Confocal microscopy supported by new algorithms for image analysis reveals that lamin A/C knock-down leads to PcG protein foci disassembly and PcG protein dispersion. This causes detachment from chromatin and defects in PcG protein–mediated higher-order structures, thereby leading to impaired PcG protein repressive functions. Using myogenic differentiation as a model, we found that reduced levels of lamin A/C at the onset of differentiation led to an anticipation of the myogenic program because of an alteration of PcG protein–mediated transcriptional repression. Collectively, our results indicate that lamin A/C can modulate transcription through the regulation of PcG protein epigenetic factors. PMID:26553927

  2. Fluorescent image tracking velocimeter

    DOEpatents

    Shaffer, Franklin D.

    1994-01-01

    A multiple-exposure fluorescent image tracking velocimeter (FITV) detects and measures the motion (trajectory, direction and velocity) of small particles close to light scattering surfaces. The small particles may follow the motion of a carrier medium such as a liquid, gas or multi-phase mixture, allowing the motion of the carrier medium to be observed, measured and recorded. The main components of the FITV include: (1) fluorescent particles; (2) a pulsed fluorescent excitation laser source; (3) an imaging camera; and (4) an image analyzer. FITV uses fluorescing particles excited by visible laser light to enhance particle image detectability near light scattering surfaces. The excitation laser light is filtered out before reaching the imaging camera allowing the fluoresced wavelengths emitted by the particles to be detected and recorded by the camera. FITV employs multiple exposures of a single camera image by pulsing the excitation laser light for producing a series of images of each particle along its trajectory. The time-lapsed image may be used to determine trajectory and velocity and the exposures may be coded to derive directional information.

  3. Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.

    PubMed

    Akimoto, Yusuke; Yamamoto, Seiji; Iida, Satoshi; Hirose, Yutaka; Tanaka, Aki; Hanaoka, Fumio; Ohkuma, Yoshiaki

    2014-12-01

    In eukaryotes, positive cofactor 4 (PC4) stimulates activator-dependent transcription by facilitating transcription initiation and the transition from initiation to elongation. It also forms homodimers and binds to single-stranded DNA and various transcriptional activators, including the general transcription factor TFIIH. In this study, we further investigated PC4 from Homo sapiens and the nematode Caenorhabditis elegans (hPC4 and cePC4, respectively). hPC4 strongly stimulated transcription on a linearized template, whereas it alleviated transcription on a supercoiled template. Transcriptional stimulation by PC4 was also alleviated by increasing the amount of TFIID. GST pull-down studies with general transcription factors indicated that both hPC4 and cePC4 bind strongly to TFIIB, TFIIEβ, TFIIFα, TFIIFβ and TFIIH XPB subunits and weakly to TBP and TFIIH p62. However, only hPC4 bound to CDK7. The effect of each PC4 on transcription was studied in combination with TFIIEβ. hPC4 stimulated both basal and activated transcription, whereas cePC4 primarily stimulated activated transcription, especially in the presence of TFIIEβ from C. elegans. Finally, hPC4 bound to the C-terminal region of hTFIIEβ adjacent to the basic region. These results indicate that PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEβ.

  4. Expression and localization of prohormone convertase PC1 in the calcitonin-producing cells of the bullfrog ultimobranchial gland.

    PubMed

    Yaoi, Yuichi; Suzuki, Masakazu; Tomura, Hideaki; Kurabuchi, Shingo; Sasayama, Yuichi; Tanaka, Shigeyasu

    2003-11-01

    We examined the expression and localization of the prohormone convertases, PC1 and PC2, in the ultimobranchial gland of the adult bullfrog using immunohistochemical (IHC) and in situ hybridization (ISH) techniques. In the ultimobranchial gland, PC1-immunoreactive cells were columnar, and were present in the follicular epithelium. When serial sections were immunostained with anti-calcitonin, anti-CGRP, anti-PC1, and anti-PC2 sera, PC1 was found only in the calcitonin/CGRP-producing cells. No PC2-immunopositive cells were detected. In the ISH, PC1 mRNA-positive cells were detected in the follicle cells in the ultimobranchial gland. No PC2 mRNA-positive cells were detected. RT-PCR revealed expression of the mRNAs of PC1 and the PC2 in the ultimobranchial gland. However, very little of the PC2 mRNA is probably translated because no PC2 protein was detected either by IHC staining or by Western blotting analysis. We conclude that the main prohormone convertase that is involved in the proteolytic cleavage of procalcitonin in the bullfrog is PC1. PMID:14566018

  5. Expression and Localization of Prohormone Convertase PC1 in the Calcitonin-producing Cells of the Bullfrog Ultimobranchial Gland

    PubMed Central

    Yaoi, Yuichi; Suzuki, Masakazu; Tomura, Hideaki; Kurabuchi, Shingo; Sasayama, Yuichi; Tanaka, Shigeyasu

    2003-01-01

    We examined the expression and localization of the prohormone convertases, PC1 and PC2, in the ultimobranchial gland of the adult bullfrog using immunohistochemical (IHC) and in situ hybridization (ISH) techniques. In the ultimobranchial gland, PC1-immunoreactive cells were columnar, and were present in the follicular epithelium. When serial sections were immunostained with anti-calcitonin, anti-CGRP, anti-PC1, and anti-PC2 sera, PC1 was found only in the calcitonin/CGRP-producing cells. No PC2-immunopositive cells were detected. In the ISH, PC1 mRNA-positive cells were detected in the follicle cells in the ultimobranchial gland. No PC2 mRNA-positive cells were detected. RT-PCR revealed expression of the mRNAs of PC1 and the PC2 in the ultimobranchial gland. However, very little of the PC2 mRNA is probably translated because no PC2 protein was detected either by IHC staining or by Western blotting analysis. We conclude that the main prohormone convertase that is involved in the proteolytic cleavage of procalcitonin in the bullfrog is PC1. PMID:14566018

  6. Context-aware visual tracking.

    PubMed

    Yang, Ming; Wu, Ying; Hua, Gang

    2009-07-01

    Enormous uncertainties in unconstrained environments lead to a fundamental dilemma that many tracking algorithms have to face in practice: Tracking has to be computationally efficient, but verifying whether or not the tracker is following the true target tends to be demanding, especially when the background is cluttered and/or when occlusion occurs. Due to the lack of a good solution to this problem, many existing methods tend to be either effective but computationally intensive by using sophisticated image observation models or efficient but vulnerable to false alarms. This greatly challenges long-duration robust tracking. This paper presents a novel solution to this dilemma by considering the context of the tracking scene. Specifically, we integrate into the tracking process a set of auxiliary objects that are automatically discovered in the video on the fly by data mining. Auxiliary objects have three properties, at least in a short time interval: 1) persistent co-occurrence with the target, 2) consistent motion correlation to the target, and 3) easy to track. Regarding these auxiliary objects as the context of the target, the collaborative tracking of these auxiliary objects leads to efficient computation as well as strong verification. Our extensive experiments have exhibited exciting performance in very challenging real-world testing cases.

  7. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... vehicle/track interaction safety limits and geometry requirements of this subpart. (b) Track shall have... shall return following maximum load to a configuration in compliance with the vehicle/track...

  8. Disentangling the hadronic molecule nature of the Pc(4380) pentaquark-like structure

    NASA Astrophysics Data System (ADS)

    Shen, Chao-Wei; Guo, Feng-Kun; Xie, Ju-Jun; Zou, Bing-Song

    2016-10-01

    We demonstrate that the relative ratio of the decays of hidden charm pentaquark-like structure Pc+ (4380) to Dbar* Λc+ and J / ψp is very different for Pc+ being D bar Σc* (2520) or Dbar*Σc (2455) molecule states. While the partial width of the D bar Σc* (2520) molecule to the Dbar*Λc+ is much larger, by one order of magnitude, than that to the J / ψp, the Dbar*Σc (2455) molecule shows a different pattern. Our analysis shows that the D bar Σc* bound state ansatz is more reasonable than the Dbar*Σc one to explain the broad Pc (4380) structure. We suggest to search for the Pc (4380) in the Dbar* Λc+ system, which can be used to disentangle the nature of the Pc+ (4380) structure.

  9. Neural network tracking and extension of positive tracking periods

    NASA Technical Reports Server (NTRS)

    Hanan, Jay C.; Chao, Tien-Hsin; Moreels, Pierre

    2004-01-01

    Feature detectors have been considered for the role of supplying additional information to a neural network tracker. The feature detector focuses on areas of the image with significant information. Basically, if a picture says a thousand words, the feature detectors are looking for the key phrases (keypoints). These keypoints are rotationally invariant and may be matched across frames. Application of these advanced feature detectors to the neural network tracking system at JPL has promising potential. As part of an ongoing program, an advanced feature detector was tested for augmentation of a neural network based tracker. The advance feature detector extended tracking periods in test sequences including aircraft tracking, rover tracking, and simulated Martian landing. Future directions of research are also discussed.

  10. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Donnell, B.

    1994-01-01

    and require an 80386 CPU or better. Users needing an 8086/8088 or 80286 executable must recompile the CLIPS source code themselves. Users who wish to recompile the DOS executable using Borland C++ or MicroSoft C must use a DOS extender program to produce an executable capable of using extended memory. The version of CLIPS 6.0 for IBM PC compatibles requires DOS v3.3 or later and/or Windows 3.1 or later. It is distributed on a set of three 1.4Mb 3.5 inch diskettes. A hard disk is required. The Macintosh version is distributed in compressed form on two 3.5 inch 1.4Mb Macintosh format diskettes, and requires System 6.0.5, or higher, and 1Mb RAM. The version for DEC VAX/VMS is available in VAX BACKUP format on a 1600 BPI 9-track magnetic tape (standard distribution medium) or a TK50 tape cartridge. The UNIX version is distributed in UNIX tar format on a .25 inch streaming magnetic tape cartridge (Sun QIC-24). For the UNIX version, alternate distribution media and formats are available upon request. The CLIPS 6.0 documentation includes a User's Guide and a three volume Reference Manual consisting of Basic and Advanced Programming Guides and an Interfaces Guide. An electronic version of the documentation is provided on the distribution medium for each version: in MicroSoft Word format for the Macintosh and PC versions of CLIPS, and in both PostScript format and MicroSoft Word for Macintosh format for the UNIX and DEC VAX versions of CLIPS. CLIPS was developed in 1986 and Version 6.0 was released in 1993.

  11. Comparison between the polar cap index, PC and the auroral electrojet indices AE, AL, and AU

    SciTech Connect

    Vennerstrom, S.; Friis-Christensen, E. ); Troshichev, O.A.; Andresen, V.G. )

    1991-01-01

    The newly introduced index PC for magnetic activity in the polar cap has been examined to establish to which extent it can serve as an indicator of auroral electrojet activity. PC is derived from a single nearpole station, as a 15-min average index. The authors have derived it for two stations, one in the northern hemisphere (Thule) and one in the southern hemisphere (Vostok). The simplicity of the PC index enables us to make a large data base for statistical investigations. They have thus used 7 years of PC values for the two stations to analyze the relationship between PC and the auroral zone indices AE, AU, and AL statistically. They find a very high correlation between PC and AE during winter and equinox, the linear correlation coefficient being {approximately} 0.8-0.9 for Thule and {approximately} 0.7-0.8 for Vostok. During summer the correlation is less because the PC index is then disturbed by polar cap currents controlled by the northward and east-west components of the interplanetary magnetic field. They therefore stress the importance of having PC available from both the northern and southern hemisphere. From event studies they find that PC is sensitive both to DP 2 type electrojet activity and to substorm intensifications of the westward electrojet in the midnight or postmidnight sector but less sensitive to substorm intensifications of the westward electrojet in the midnight or post midnight sector. They conclude that PC can serve as a fast available indicator of DP 2 and DP 1 activity in the polar regions, excluding intrusions of the westward electrojet in the premidnight sector.

  12. Cytotoxic Effects of the Ethanol Bane Skin Extract in Human Prostate Cancer Pc3 Cells

    PubMed Central

    Amiri, Maryam; Kazerouni, Faranak; Namaki, Saeed; Darbandi Tamijani, Hassan; Rahimipour, Hooman; Boroumand, Nasrin; Barghi, Siyamak; Ebrahimi, Nazanin; Gheibi Hayat, Seyed Mohammad

    2016-01-01

    Background: It is extensively supposed that vegetarian diet could affect cancer progress and increase the influence of formal chemotherapy. Objectives: The present study was designed to determine the effect of the ethanol Bane skin extract against chemo resistant prostate cancer PC3 cells. Materials and Methods: PC3 and L929 cells were cultivated and then incubated in the ethanol Bane skin extract with various concentrations of 0.78, 1.5, 3.13, 6.25, 12.5 mg/mL in 3 times 24, 48, 72 hours. Cytotoxic effect of the ethanol Bane skin extract on PC3 and L929 cells was examined by MTT assay after 24, 48, and 72 hours. Morphology of PC3 cells was evaluated by Gimsa staining. Results: The ethanol Bane skin extract inhibited proliferation and caused cell death with IC50 values of 2.8 mg/mL on PC3 cells and the IC50 was 6.1 mg/mL on l929 cells. Morphological changes and apoptotic bodies were observed in PC3 cells faced with the ethanol Bane skin extract by staining with Gimsa. Conclusions: The ethanol Bane skin extract could repress the growth of PC3 cell line. This inhibitory effect of the Bane extract depended on the dose and the time on PC3. The result of this study shows that the ethanol Bane skin extract includes photochemical and inhibitory function against proliferation and inducer of apoptosis in human prostate cancer PC3 cells and also has less cytotoxic effect on l929 than PC3 cells. The ethanol Bane skin extract might be a good candidate for the new herbal anticancer drug. PMID:27482333

  13. High resolution track etch autoradiography

    DOEpatents

    Solares, Guido; Zamenhof, Robert G.

    1994-01-01

    A detector assembly for use in obtaining alpha-track autoradiographs, the detector assembly including a substantially boron-free substrate; a detector layer deposited on the substantially boron-free substrate, the detector layer being capable of recording alpha particle tracks and exhibiting evidence of the alpha tracks in response to being exposed to an etchant, the detector layer being less than about 2 microns thick; and a protective layer deposited on the detector layer, the protective layer being resistant to the etchant and having a thickness of about 0.5 to 1 microns.

  14. High resolution track etch autoradiography

    DOEpatents

    Solares, G.; Zamenhof, R.G.

    1994-12-27

    A detector assembly is disclosed for use in obtaining alpha-track autoradiographs, the detector assembly including a substantially boron-free substrate; a detector layer deposited on the substantially boron-free substrate, the detector layer being capable of recording alpha particle tracks and exhibiting evidence of the alpha tracks in response to being exposed to an etchant, the detector layer being less than about 2 microns thick; and a protective layer deposited on the detector layer, the protective layer being resistant to the etchant and having a thickness of about 0.5 to 1 microns. 13 figures.

  15. Abrasion resistant track shoe grouser

    SciTech Connect

    Fischer, Keith D; Diekevers, Mark S; Afdahl, Curt D; Steiner, Kevin L; Barnes, Christopher A

    2013-04-23

    A track shoe for a track-type vehicle. The track shoe includes a base plate and a grouser projecting away from the base plate. A capping surface structure of substantially horseshoe shaped cross-section is disposed across a distal portion of the grouser. The capping surface structure covers portions of a distal edge surface and adjacent lateral surfaces. The capping surface structure is formed from an material characterized by enhanced wear resistance relative to portions of the grouser underlying the capping surface structure.

  16. High-dynamic GPS tracking

    NASA Technical Reports Server (NTRS)

    Hinedi, S.; Statman, J. I.

    1988-01-01

    The results of comparing four different frequency estimation schemes in the presence of high dynamics and low carrier-to-noise ratios are given. The comparison is based on measured data from a hardware demonstration. The tested algorithms include a digital phase-locked loop, a cross-product automatic frequency tracking loop, and extended Kalman filter, and finally, a fast Fourier transformation-aided cross-product frequency tracking loop. The tracking algorithms are compared on their frequency error performance and their ability to maintain lock during severe maneuvers at various carrier-to-noise ratios. The measured results are shown to agree with simulation results carried out and reported previously.

  17. Visual object recognition and tracking

    NASA Technical Reports Server (NTRS)

    Chang, Chu-Yin (Inventor); English, James D. (Inventor); Tardella, Neil M. (Inventor)

    2010-01-01

    This invention describes a method for identifying and tracking an object from two-dimensional data pictorially representing said object by an object-tracking system through processing said two-dimensional data using at least one tracker-identifier belonging to the object-tracking system for providing an output signal containing: a) a type of the object, and/or b) a position or an orientation of the object in three-dimensions, and/or c) an articulation or a shape change of said object in said three dimensions.

  18. Sun Tracking Systems: A Review

    PubMed Central

    Lee, Chia-Yen; Chou, Po-Cheng; Chiang, Che-Ming; Lin, Chiu-Feng

    2009-01-01

    The output power produced by high-concentration solar thermal and photovoltaic systems is directly related to the amount of solar energy acquired by the system, and it is therefore necessary to track the sun's position with a high degree of accuracy. Many systems have been proposed to facilitate this task over the past 20 years. Accordingly, this paper commences by providing a high level overview of the sun tracking system field and then describes some of the more significant proposals for closed-loop and open-loop types of sun tracking systems. PMID:22412341

  19. The Automatic Library Tracking Database

    SciTech Connect

    Fahey, Mark R; Jones, Nicholas A; Hadri, Bilel

    2010-01-01

    A library tracking database has been developed and put into production at the National Institute for Computational Sciences and the Oak Ridge Leadership Computing Facility (both located at Oak Ridge National Laboratory.) The purpose of the library tracking database is to track which libraries are used at link time on Cray XT5 Supercomputers. The database stores the libraries used at link time and also records the executables run in a batch job. With this data, many operationally important questions can be answered such as which libraries are most frequently used and which users are using deprecated libraries or applications. The infrastructure design and reporting mechanisms are presented along with collected production data.

  20. Robust track fitting in the Belle II inner tracking detector

    NASA Astrophysics Data System (ADS)

    Nadler, Moritz; Frühwirth, Rudolf

    2012-12-01

    Track fitting in the new inner tracker of the Belle II experiment uses the GENFIT package. In the latter both a standard Kalman filter and a robust extension, the deterministic annealing filter (DAF), are implemented. This contribution presents the results of a simulation experiment which examines the performance of the DAF in the inner tracker, in terms of outlier detection ability and of the impact of different kinds of background on the quality of the fitted tracks.

  1. The Integrated Waste Tracking System - A Flexible Waste Management Tool

    SciTech Connect

    Anderson, Robert Stephen

    2001-02-01

    The US Department of Energy (DOE) Idaho National Engineering and Environmental Laboratory (INEEL) has fully embraced a flexible, computer-based tool to help increase waste management efficiency and integrate multiple operational functions from waste generation through waste disposition while reducing cost. The Integrated Waste Tracking System (IWTS)provides comprehensive information management for containerized waste during generation,storage, treatment, transport, and disposal. The IWTS provides all information necessary for facilities to properly manage and demonstrate regulatory compliance. As a platformindependent, client-server and Web-based inventory and compliance system, the IWTS has proven to be a successful tracking, characterization, compliance, and reporting tool that meets the needs of both operations and management while providing a high level of management flexibility.

  2. Solid Waste Information and Tracking System (SWITS) Software Requirements Specification

    SciTech Connect

    MAY, D.L.

    2000-03-22

    This document is the primary document establishing requirements for the Solid Waste Information and Tracking System (SWITS) as it is converted to a client-server architecture. The purpose is to provide the customer and the performing organizations with the requirements for the SWITS in the new environment. This Software Requirement Specification (SRS) describes the system requirements for the SWITS Project, and follows the PHMC Engineering Requirements, HNF-PRO-1819, and Computer Software Qualify Assurance Requirements, HNF-PRO-309, policies. This SRS includes sections on general description, specific requirements, references, appendices, and index. The SWITS system defined in this document stores information about the solid waste inventory on the Hanford site. Waste is tracked as it is generated, analyzed, shipped, stored, and treated. In addition to inventory reports a number of reports for regulatory agencies are produced.

  3. PC/FRAM, Version 3.2 User Manual

    SciTech Connect

    Kelley, T.A.; Sampson, T.E.

    1999-02-23

    This manual describes the use of version 3.2 of the PC/FRAM plutonium isotopic analysis software developed in the Safeguards Science and Technology Group, NE-5, Nonproliferation and International Security Division Los Alamos National Laboratory. The software analyzes the gamma ray spectrum from plutonium-bearing items and determines the isotopic distribution of the plutonium 241Am content and concentration of other isotopes in the item. The software can also determine the isotopic distribution of uranium isotopes in items containing only uranium. The body of this manual descnies the generic version of the code. Special facility-specific enhancements, if they apply, will be described in the appendices. The information in this manual applies equally well to version 3.3, which has been licensed to ORTEC. The software can analyze data that is stored in a file on disk. It understands several storage formats including Canberra's S1OO format, ORTEC'S `chn' and `SPC' formats, and several ASCII text formats. The software can also control data acquisition using an MCA and then store the results in a file on disk for later analysis or analyze the spectrum directly after the acquisition. The software currently only supports the control of ORTEC MCB'S. Support for Canbema's Genie-2000 Spectroscopy Systems will be added in the future. Support for reading and writing CAM files will also be forthcoming. A versatile parameter fde database structure governs all facets of the data analysis. User editing of the parameter sets allows great flexibility in handling data with different isotopic distributions, interfering isotopes, and different acquisition parameters such as energy calibration, and detector type. This manual is intended for the system supervisor or the local user who is to be the resident expert. Excerpts from this manual may also be appropriate for the system operator who will routinely use the instrument.

  4. Manganese oxidation state mediates toxicity in PC12 cells

    SciTech Connect

    Reaney, S.H. . E-mail: stevereaney@hotmail.com; Smith, D.R.

    2005-06-15

    The role of the manganese (Mn) oxidation state on cellular Mn uptake and toxicity is not well understood. Therefore, undifferentiated PC12 cells were exposed to 0-200 {mu}M Mn(II)-chloride or Mn(III)-pyrophosphate for 24 h, after which cellular manganese levels were measured along with measures of cell viability, function, and cytotoxicity (trypan blue exclusion, medium lactate dehydrogenase (LDH), 8-isoprostanes, cellular ATP, dopamine, serotonin, H-ferritin, transferrin receptor (TfR), Mn-superoxide dismutase (MnSOD), and copper-zinc superoxide dismutase (CuZnSOD) protein levels). Exposures to Mn(III) >10 {mu}M produced 2- to 5-fold higher cellular manganese levels than equimolar exposures to Mn(II). Cell viability and ATP levels both decreased at the highest Mn(II) and Mn(III) exposures (150-200 {mu}M), while Mn(III) exposures produced increases in LDH activity at lower exposures ({>=}50 {mu}M) than did Mn(II) (200 {mu}M only). Mn(II) reduced cellular dopamine levels more than Mn(III), especially at the highest exposures (50% reduced at 200 {mu}M Mn(II)). In contrast, Mn(III) produced a >70% reduction in cellular serotonin at all exposures compared to Mn(II). Different cellular responses to Mn(II) exposures compared to Mn(III) were also observed for H-ferritin, TfR, and MnSOD protein levels. Notably, these differential effects of Mn(II) versus Mn(III) exposures on cellular toxicity could not simply be accounted for by the different cellular levels of manganese. These results suggest that the oxidation state of manganese exposures plays an important role in mediating manganese cytotoxicity.

  5. METHANE DE-NOX FOR UTILITY PC BOILERS

    SciTech Connect

    Bruce Bryan; Joseph Rabovitser; Serguei Nester; Stan Wohadlo

    2004-02-06

    The primary focus for the project continues to be on developing a PC PREHEAT system design suitable for use with caking coals and readying the 100 MMBtu/h CBTF for testing with noncaking PRB coal. During the current quarter, twenty-two pilot tests were conducted with Central Appalachian (CA) caking coal. The objective for these tests was to achieve continuous operation of the pilot system at its design coal feed rate of 156 lb/h, without plugging or agglomeration in the combustor. One combustor air distribution method tested achieved continuous operation at 110 lb/hr, and inspection of the combustor afterward indicated that this method has potential to solve the caking problem. The NOx results from the pilot caking coal runs indicate that even greater NOx reduction is possible with CA coal than with the PRB coal tested, to levels near 100 ppmv or lower at 4-6% exit oxygen. It was therefore decided to conduct additional pilot tests of the air distribution method to determine how to incorporate this into a workable CA combustor design. Based on current weather and manpower restrictions at the site, this pilot testing is expected to be started in February. The design for the 100 MMBtu/h unit for PRB testing in the CBTF was completed and fabrication and installation started during the quarter. While significant progress has been made in the installation of the unit, weather and combustor fabrication delays are expected to move the start of large-scale testing with PRB coal into February, which will push the project completion date beyond the current 3/30/04 end date. GTI is in the process of developing a revised project schedule and estimated cost to complete.

  6. AKPLOT- A PLOTTER ROUTINE FOR THE IBM PC

    NASA Technical Reports Server (NTRS)

    Kantak, A. V.

    1994-01-01

    The AKPLOT routine was designed for engineers and scientists who use graphs as an integral part of their documentation. AKPLOT allows the user to generate a graph and edit its appearance on a CRT. This graph may undergo many interactive alterations before it is finally screen dumped to a printer for a hard copy plot. The finished AKPLOT graph may be stored in a file for future use. Features available in AKPLOT include: multiple curves on a single plot; combinations of linear and logarithmic scale axes; Lagrange interpolation of selected curves; shrink, expand, zoom, and tilt; ten different symbols and four different colors for curves; and three different grid types. AKPLOT enables the user to perform least squares fitting of all or selected curves with polynomials of up to 99 degrees and examine the least squares coefficients. The user must provide the data points to be plotted by one of two methods: 1) supplying an external file of X-Y values for all curves, or 2) computing the X-Y vectors by either placing BASIC code describing the relation in a designated section of the AKPLOT code or dynamically entering a one line function. Using either technique, the X-Y values are input to the computer only once, as the iterative graph edit loop bypasses the data input step for faster execution. AKPLOT is written in BASIC for interactive execution and has been implemented on an IBM PC series computer operating under DOS. AKPLOT requires a graphics board and a color monitor. This program was originally developed in 1986 and later revised in 1987.

  7. Translationally Controlled Tumor Protein Stimulates Dopamine Release from PC12 Cells via Ca2+-Independent Phospholipase A2 Pathways

    PubMed Central

    Seo, Jihui; Maeng, Jeehye; Kim, Hwa-Jung

    2016-01-01

    The translationally controlled tumor protein (TCTP), initially identified as a tumor- and growth-related protein, is also known as a histamine-releasing factor (HRF). TCTP is widely distributed in the neuronal systems, but its function is largely uncharacterized. Here, we report a novel function of TCTP in the neurotransmitter release from a neurosecretory, pheochromocytoma (PC12) cells. Treatment with recombinant TCTP (rTCTP) enhanced both basal and depolarization (50 mM KCl)-evoked [3H]dopamine release in concentration- and time-dependent manners. Interestingly, even though rTCTP induced the increase in intracellular calcium levels ([Ca2+]i), the rTCTP-driven effect on dopamine release was mediated by a Ca2+-independent pathway, as evidenced by the fact that Ca2+-modulating agents such as Ca2+ chelators and a voltage-gated L-type Ca2+-channel blocker did not produce any changes in rTCTP-evoked dopamine release. In a study to investigate the involvement of phospholipase A2 (PLA2) in rTCTP-induced dopamine release, the inhibitor for Ca2+-independent PLA2 (iPLA2) produced a significant inhibitory effect on rTCTP-induced dopamine release, whereas this release was not significantly inhibited by Ca2+-dependent cytosolic PLA2 (cPLA2) and secretory PLA2 (sPLA2) inhibitors. We found that rTCTP-induced dopamine release from neuronal PC12 cells was modulated by a Ca2+-independent mechanism that involved PLA2 in the process, suggesting the regulatory role of TCTP in the neuronal functions. PMID:27783042

  8. Theoretical and user`s manual for pc-PRAISE: A probabilistic fracture mechanics computer code for piping reliability analysis

    SciTech Connect

    Harris, D.O.; Dedhia, D.D.; Lu, S.C.

    1992-07-01

    The purpose of this document is to collect under one cover and update the documentation related to the PRAISE Computer Code. pc-PRAISE is the most recent version of the code, which is a probabilistic fracture mechanics code that has recently been modified to run on an IBM personal computer to evaluate the reliability of welds in nuclear power plant piping systems. pc-PRAISE was adapted from the PRAISE Computer Code, which was originally developed in 1980--81 by Lawrence Livermore National Laboratory (LLNL) under funding from the US Nuclear Regulatory Commission for assessment of the influence of seismic events on the failure probability of piping in pressurized water reactors. PRAISE is an acronym for Piping Reliability Analysis Including Seismic Events, and has been significantly expanded in recent years to allow consideration of both crack initiation and growth in a variety of piping materials in pressurized and boiling water reactors. PRAISE has a deterministic basis in fracture mechanics. Some of the inputs, such as initial crack size and inspection detection probability, are considered to be random variables, and failure probability versus time for a given weldment is evaluated by Monte Carlo simulation. Complex realistic stress histories can be treated by the code, and sets of random material properties for representative piping materials are built into the code. This document provides a comprehensive summary of the deterministic basis of the code, along with description of statistical distributions of random variables. Code inputs are described and an extensive set of sample problems is provided along with descriptions of representative outputs.

  9. Theoretical and user's manual for pc-PRAISE: A probabilistic fracture mechanics computer code for piping reliability analysis

    SciTech Connect

    Harris, D.O.; Dedhia, D.D. ); Lu, S.C. )

    1992-07-01

    The purpose of this document is to collect under one cover and update the documentation related to the PRAISE Computer Code. pc-PRAISE is the most recent version of the code, which is a probabilistic fracture mechanics code that has recently been modified to run on an IBM personal computer to evaluate the reliability of welds in nuclear power plant piping systems. pc-PRAISE was adapted from the PRAISE Computer Code, which was originally developed in 1980--81 by Lawrence Livermore National Laboratory (LLNL) under funding from the US Nuclear Regulatory Commission for assessment of the influence of seismic events on the failure probability of piping in pressurized water reactors. PRAISE is an acronym for Piping Reliability Analysis Including Seismic Events, and has been significantly expanded in recent years to allow consideration of both crack initiation and growth in a variety of piping materials in pressurized and boiling water reactors. PRAISE has a deterministic basis in fracture mechanics. Some of the inputs, such as initial crack size and inspection detection probability, are considered to be random variables, and failure probability versus time for a given weldment is evaluated by Monte Carlo simulation. Complex realistic stress histories can be treated by the code, and sets of random material properties for representative piping materials are built into the code. This document provides a comprehensive summary of the deterministic basis of the code, along with description of statistical distributions of random variables. Code inputs are described and an extensive set of sample problems is provided along with descriptions of representative outputs.

  10. 77 FR 7972 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... agenda pursuant to Executive Order 12866, ``Regulatory Planning and Review,'' 58 FR 51735, and the... Identifier No. 396 National Standards to 1105-AB34 Prevent, Detect, and Respond to Prison Rape (Reg Plan Seq... Prevent, Detect, and Respond to Prison Rape Regulatory Plan: This entry is Seq. No. 85 in part II of...

  11. 78 FR 1634 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Administration (NASA). ACTION: Semiannual regulatory agenda. SUMMARY: NASA's regulatory agenda describes those regulations being considered for development or amendment by NASA, the need and legal basis for the actions... Controls and Management Systems, Office of Management Systems Division, NASA Headquarters, Washington,...

  12. 78 FR 1574 - Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... and stability to receive opioid addiction treatment medication. Timetable: Action Date FR Cite NPRM 06/19/09 74 FR 29153 NPRM Comment Period End 08/18/09 Final Action 12/06/12 77 FR 72752 Regulatory... FR Cite NPRM 03/00/13 Regulatory Flexibility Analysis Required: Yes. Agency Contact: Charles...

  13. Regulatory Foci and Organizational Commitment

    ERIC Educational Resources Information Center

    Markovits, Yannis; Ullrich, Johannes; van Dick, Rolf; Davis, Ann J.

    2008-01-01

    We use regulatory focus theory to derive specific predictions regarding the differential relationships between regulatory focus and commitment. We estimated a structural equation model using a sample of 520 private and public sector employees and found in line with our hypotheses that (a) promotion focus related more strongly to affective…

  14. Conceptual Design of Oxygen-Based PC Boiler

    SciTech Connect

    Andrew Seltzer; Zhen Fan

    2005-09-01

    sequestration. FW has developed a conceptual design of an O{sub 2} fired boiler to determine overall plant performance and economics. Five subtasks were conducted: (1) a literature review, (2) a system design and analysis, (3) a low NOx burner design and analysis, (4) a furnace and heat recovery area design analysis, and (5) an economic analysis. The objective of the literature search is to locate any data/information relevant to the Oxygen-Based PC Boiler conceptual design. The objective of the system design and analysis task is to optimize the PC boiler plant by maximizing system efficiency within practical considerations. Simulations of the oxygen-fired plant with CO{sub 2} sequestration were conducted using Aspen Plus and were compared to a reference air-fired 460 MW plant. Flue gas recycle is used in the O{sub 2}-fired PC to control the flame temperature. Parametric runs were made to determine the effect of flame temperature on system efficiency and required waterwall material and thickness. The degree of improvement on system efficiency of various modifications including hot gas recycle, purge gas recycle, flue gas feedwater recuperation, and recycle purge gas expansion were investigated. The selected O{sub 2}-fired design case has a system efficiency of 30.6% compared to the air-fired system efficiency of 36.7%. The design O{sub 2}-fired case requires T91 waterwall material and has a waterwall surface area of only 65% of the air-fired reference case. The objective of the low NOx burner design and analysis task is to optimize the burner design to ensure stable ignition, to provide safe operation, and to minimize pollutant formation. The burners were designed and analyzed using the Fluent CFD computer program. Four burner designs were developed: (1) with no OFG and 65% flue gas recycle, (2) with 20% OFG and 65% flue gas recycle, (3) with no OFG and 56% flue gas recycle and (4) with 20% OFG and 56% flue gas recycle. A 3-D Fluent simulation was made of a single wall

  15. Environmental exposure tracking sensor

    NASA Astrophysics Data System (ADS)

    Havens, Teresa; Everhart, Joel; McFerran, Jace

    2009-03-01

    Cornerstone Research Group Inc. (CRG) has developed environmental exposure tracking (EET) sensors using shape memory polymer (SMP) to monitor the degradation of perishable items, such as munitions, medicines or foods, by measuring the cumulative exposure to temperature and moisture. SMPs are polymers whose qualities have been altered to give them dynamic shape "memory" properties. Under thermal or moisture stimuli, SMP exhibits a radical change from a rigid thermoset to a highly flexible, elastic state. The dynamic response of the SMP can be tailored to match the degradation profile of the perishable item. SMP-based EET sensors require no digital memory or internal power supply and provide the capability of inexpensive, long-term life cycle monitoring thermal and moisture exposure over time. In a Phase I and II SBIR effort with the Navy, CRG demonstrated the feasibility of SMP-based EET sensor with two material systems. These material systems required different activation stimuli, heat or water vapor pressure. CRG developed the ability to tailor these materials to customize the dynamic response to match various degradation profiles of munitions. CRG optimized and characterized the SMP formulations and sensor design configuration to develop a suite of data from which any degradation profile can be met. CRG's EET sensors are capable of monitoring temperatures from -30 °C to 260 °C. The prototypes monitor cumulative thermal exposure and provide real-time information in a visually readable or a remotely interrogated version. CRG is currently scaling up the manufacture of the sensors for munitions reliability applications with the Navy.

  16. The Physics of Fast Track

    ERIC Educational Resources Information Center

    Kibble, Bob

    2007-01-01

    Toys can provide motivational contexts for learning and teaching about physics. A cheap car track provides an almost frictionless environment from which a quantitative study of conservation of energy and circular motion can be made.

  17. Tracking Down the Real Story.

    ERIC Educational Resources Information Center

    Dyche, Steven E.; Stefanich, Greg

    1989-01-01

    Presents a strategy for science learning through a game activity which uses human and/or animal footprints. Provides numerous ideas for creativity in constructing a story and adapting tracks for experiential experiences. (RT)

  18. Map projections for satellite tracking.

    USGS Publications Warehouse

    Snyder, J.P.

    1981-01-01

    New map projections to be used for plotting successive satellite groundtracks show these tracks as straight lines. The map may be made conformal along any 2 parallels of latitude between the limits of latitude reached by the groundtrack, or the 'tracking limits'. If these parallels are equidistant from the Equator, they may both be made true to scale, and a cylindrical projection results. If these parallels are not equidistant from the Equator, only one may be made true to scale, and a conic projection results. The groundtracks generally have sharp breaks at either tracking limit. If the tracking limit is one of the parallels at which the map is conformal, there is no break in the groundtrack, and the conic projection may approach (but cannot become) an azimuthal projection.-Author

  19. Automatic electronic fish tracking system

    NASA Technical Reports Server (NTRS)

    Osborne, P. W.; Hoffman, E.; Merriner, J. V.; Richards, C. E.; Lovelady, R. W.

    1976-01-01

    A newly developed electronic fish tracking system to automatically monitor the movements and migratory habits of fish is reported. The system is aimed particularly at studies of effects on fish life of industrial facilities which use rivers or lakes to dump their effluents. Location of fish is acquired by means of acoustic links from the fish to underwater Listening Stations, and by radio links which relay tracking information to a shore-based Data Base. Fish over 4 inches long may be tracked over a 5 x 5 mile area. The electronic fish tracking system provides the marine scientist with electronics which permit studies that were not practical in the past and which are cost-effective compared to manual methods.

  20. FFTF Asbestos Location Tracking Program

    SciTech Connect

    Reynolds, J.A.

    1994-09-15

    An Asbestos Location Tracking Program was prepared to list, locate, and determine Asbestos content and to provide baseline {open_quotes}good faith{close_quotes} for yearly condition inspections for the FFTF Plant and buildings and grounds.

  1. Ambipolar organic heterojunction transistors based on F16CuPc/CuPc with a MoO3 buffer layer

    NASA Astrophysics Data System (ADS)

    Mingdong, Yi; Ning, Zhang; Linghai, Xie; Wei, Huang

    2015-10-01

    We fabricated heterojunction organic field-effect transistors (OFETs) using copper phthalocyanine (CuPc) and hexadecafluorophtholocyaninatocopper (F16CuPc) as hole transport layer and electron transport layer, respectively. Compared with F16CuPc based OFETs, the electron field-effect mobility in the heterojunction OFETs increased from 3.1 × 10-3 to 8.7 × 10-3 cm2/(V·s), but the p-type behavior was not observed. To enhanced the hole injection, we modified the source-drain electrodes using the MoO3 buffer layer, and the hole injection can be effectively improved. Eventually, the ambipolar transport characteristics of the CuPc/F16CuPc based OFETs with a MoO3 buffer layer were achieved, and the field-effect mobilities of electron and hole were 2.5 × 10-3 and 3.1 × 10-3 cm2/(V·s), respectively. Project supported by the National Natural Science Foundation of China (Nos. 61475074, 61204095).

  2. Precision laser automatic tracking system.

    PubMed

    Lucy, R F; Peters, C J; McGann, E J; Lang, K T

    1966-04-01

    A precision laser tracker has been constructed and tested that is capable of tracking a low-acceleration target to an accuracy of about 25 microrad root mean square. In tracking high-acceleration targets, the error is directly proportional to the angular acceleration. For an angular acceleration of 0.6 rad/sec(2), the measured tracking error was about 0.1 mrad. The basic components in this tracker, similar in configuration to a heliostat, are a laser and an image dissector, which are mounted on a stationary frame, and a servocontrolled tracking mirror. The daytime sensitivity of this system is approximately 3 x 10(-10) W/m(2); the ultimate nighttime sensitivity is approximately 3 x 10(-14) W/m(2). Experimental tests were performed to evaluate both dynamic characteristics of this system and the system sensitivity. Dynamic performance of the system was obtained, using a small rocket covered with retroreflective material launched at an acceleration of about 13 g at a point 204 m from the tracker. The daytime sensitivity of the system was checked, using an efficient retroreflector mounted on a light aircraft. This aircraft was tracked out to a maximum range of 15 km, which checked the daytime sensitivity of the system measured by other means. The system also has been used to track passively stars and the Echo I satellite. Also, the system tracked passively a +7.5 magnitude star, and the signal-to-noise ratio in this experiment indicates that it should be possible to track a + 12.5 magnitude star.

  3. Kalman Orbit Optimized Loop Tracking

    NASA Technical Reports Server (NTRS)

    Young, Lawrence E.; Meehan, Thomas K.

    2011-01-01

    Under certain conditions of low signal power and/or high noise, there is insufficient signal to noise ratio (SNR) to close tracking loops with individual signals on orbiting Global Navigation Satellite System (GNSS) receivers. In addition, the processing power available from flight computers is not great enough to implement a conventional ultra-tight coupling tracking loop. This work provides a method to track GNSS signals at very low SNR without the penalty of requiring very high processor throughput to calculate the loop parameters. The Kalman Orbit-Optimized Loop (KOOL) tracking approach constitutes a filter with a dynamic model and using the aggregate of information from all tracked GNSS signals to close the tracking loop for each signal. For applications where there is not a good dynamic model, such as very low orbits where atmospheric drag models may not be adequate to achieve the required accuracy, aiding from an IMU (inertial measurement unit) or other sensor will be added. The KOOL approach is based on research JPL has done to allow signal recovery from weak and scintillating signals observed during the use of GPS signals for limb sounding of the Earth s atmosphere. That approach uses the onboard PVT (position, velocity, time) solution to generate predictions for the range, range rate, and acceleration of the low-SNR signal. The low- SNR signal data are captured by a directed open loop. KOOL builds on the previous open loop tracking by including feedback and observable generation from the weak-signal channels so that the MSR receiver will continue to track and provide PVT, range, and Doppler data, even when all channels have low SNR.

  4. T follicular regulatory cells.

    PubMed

    Sage, Peter T; Sharpe, Arlene H

    2016-05-01

    Pathogen exposure elicits production of high-affinity antibodies stimulated by T follicular helper (Tfh) cells in the germinal center reaction. Tfh cells provide both costimulation and stimulatory cytokines to B cells to facilitate affinity maturation, class switch recombination, and plasma cell differentiation within the germinal center. Under normal circumstances, the germinal center reaction results in antibodies that precisely target foreign pathogens while limiting autoimmunity and excessive inflammation. In order to have this degree of control, the immune system ensures Tfh-mediated B-cell help is regulated locally in the germinal center. The recently identified T follicular regulatory (Tfr) cell subset can migrate to the germinal center and inhibit Tfh-mediated B-cell activation and antibody production. Although many aspects of Tfr cell biology are still unclear, recent data have begun to delineate the specialized roles of Tfr cells in controlling the germinal center reaction. Here we discuss the current understanding of Tfr-cell differentiation and function and how this knowledge is providing new insights into the dynamic regulation of germinal centers, and suggesting more efficacious vaccine strategies and ways to treat antibody-mediated diseases.

  5. Internationalization of regulatory requirements.

    PubMed

    Juillet, Y

    2003-02-01

    The aim of harmonisation of medicines regulatory requirements is to allow the patient quicker access to new drugs and to avoid animal and human duplications. Harmonisation in the European Union (EU) is now completed, and has led to the submission of one dossier in one language study leading to European marketing authorizations, thanks in particular to efficacy guidelines published at the European level. With the benefit of the European experience since 1989, more than 40 guidelines have been harmonised amongst the EU, Japan and the USA through the International Conference on Harmonisation (ICH). ICH is a unique process gathering regulators and industry experts from the three regions. Its activity is built on expertise and trust. The Common Technical Document (CTD), an agreed common format for application in the three regions, is a logical follow-up to the ICH first phase harmonising the content of the dossier. The CTD final implementation in July 2003 will have considerable influence on the review process and on the exchange of information in the three regions.

  6. Analysis of railway track vibration

    NASA Astrophysics Data System (ADS)

    Ono, K.; Yamada, M.

    1989-04-01

    Analytical formulae are developed for estimating the amplitudes of the vibrations generated in railway tracks by wheels and rail discontinuities or by unevennesses on their surfaces. Rails are assumed to be supported elastically on concrete sleepers by resilient rail-pads inserted between them. The elasticities and the masses of track materials and those of the roadbed are also taken into consideration. It is shown that after an impulse is applied to the track, not only is a vibration with a comparatively low natural frequency generated, but also traveling waves with higher frequencies, and the latter propagate lengthwise along the track or downwards into the roadbed. With the assumption that the power spectral density of the unevennesses on the rail surface is in proportion to the third power of the wavelength, or to (wavenumber) -3, the amplitudes of the vibrations in railway tracks supported by rail-pads and roadbeds with various magnitudes of elastic constants are analyzed and the values for each one-third octave band are estimated. The velocity of the vibration takes on a maximum value for the band with a center frequency of 63 Hz, which corresponds to the resonant frequency of the system composed of the wheel and the track. As the frequency increases beyond this value, the velocity of the vibration takes on a second maximum value at a frequency of about 1000 Hz. These estimates are compared with the data obtained from field measurements and reasonably good correlations are found between them.

  7. Digital upgrade issues and the evolving regulatory environment

    SciTech Connect

    Meininger, R. D.

    2006-07-01

    This paper deals with the qualification of an Instrumentation and Control (I and C) upgrade for Electromagnetic Compatibility (EMC) in the plant, focusing on the interpretation of the NRC Regulatory Guide 1.180 Revision 1, 'Guidelines for Evaluating Electromagnetic and Radio-Frequency Interference in Safety-Related Instrumentation and Control Systems.' Options presented by Reg. Guide 1.180 are discussed along with alternative EMC Guidelines being used by nuclear power plants. Problems commonly encountered during the EMC qualification process are discussed and suggestions presented on how to deal with these common problems. Also included is a discussion of an emerging issue of how to address the issue of EMC of replacement discrete modules or printer circuit (PC) boards in a system that was either previously qualified or never qualified for EMC. (authors)

  8. Global Pc5 pulsations during strong magnetic storms: excitation mechanisms and equatorward expansion

    NASA Astrophysics Data System (ADS)

    Marin, J. A.; Pilipenko, V.; Vega, P.; Zesta, E.; Stepanova, M. V.; Uozumi, T.

    2012-12-01

    The spatial structure of Pc5 waves during the recovery phases of strong magnetic storms is important not only for the identification of possible physical mechanisms of its excitation, but as an important parameter of the ULF driver of relativistic electrons. The dynamics of global Pc5 waves during the magnetic storms on October 29-31, 2003 and May 15, 2005 is studied, using the data from the trans-American network of magnetometers comprising SAMBA, MAGDAS, CARISMA, and MACCS arrays. We study the behavior of Pc5 wave properties and spectral characteristics with respect to latitude. One of the accepted sources of Pc5 wave activity is Kelvin-Helmholtz instability in the flanks of the magnetosphere. In our study we examine whether the KH instability is sufficient as an excitation mechanism for the observed waves? More specifically, we attempt to determine, what is the Pc5 wave generation type: self-excitation, resonant response, trigger? While the KH instability generation takes place at the outer flanks of the magnetosphere, Pc5 waves are observed at all latitudes. We determine how deep into the magnetosphere these Pc5 waves activity can extend and what is the wave energy transmission mechanism: surface mode, cavity mode, Alfven field-line resonance, magnetospheric MHD waveguide?

  9. The effect of modulating top-down attention deployment on the N2pc/PCN.

    PubMed

    Liu, Qiang; Lin, Shuyu; Zhao, Guang; Roberson, Debi

    2016-05-01

    The N2pc (PCN) component of the event-related potential (ERP) waveform provides a useful tool for directly assessing the locus of spatial attention in visual search. It is still unclear whether the amplitude of the N2pc/PCN relates to the deployment of attentional resources. A key issue is the lack of evidence that top-down allocation of attention affects the N2pc/PCN amplitude. Previous findings could be explained if manipulating different expectancy strategies changes participants' search mode, causing them to redefine the target's features. In this study, we explored the relationship between N2pc/PCN amplitude and top-down attention allocation by manipulating the discriminative difficulty (differences in the response-defining feature) but leaving the search difficulty (target's saliency) unchanged. Using the same sets of stimuli, in a blocked condition, participants showed the expected higher amplitude of N2pc/PCN in the hardest condition, compared to easier discrimination conditions. Importantly, there was no difference in the N2pc/PCN when the exact same stimulus sets were presented in a randomly interleaved mixed set. At a behavioral level, in both conditions performance was significantly slower for the hardest condition. This finding indicates that the N2pc/PCN component is modulated by the predictability of discriminative difficulty, which reflects the modulation of top-down attentional deployment.

  10. Impact of a Recombinant Biocontrol Bacterium, Pseudomonas fluorescens pc78, on Microbial Community in Tomato Rhizosphere.

    PubMed

    Kong, Hyun Gi; Kim, Nam Hee; Lee, Seung Yeup; Lee, Seon-Woo

    2016-04-01

    Pseudomonas fluorescens pc78 is an effective biocontrol agent for soil-borne fungal diseases. We previously constructed a P43-gfp tagged biocontrol bacteria P. fluorescens pc78-48 to investigate bacterial traits in natural ecosystem and the environmental risk of genetically modified biocontrol bacteria in tomato rhizosphere. Fluctuation of culturable bacteria profile, microbial community structure, and potential horizontal gene transfer was investigated over time after the bacteria treatment to the tomato rhizosphere. Tagged gene transfer to other organisms such as tomato plants and bacteria cultured on various media was examined by polymerase chain reaction, using gene specific primers. Transfer of chromosomally integrated P43-gfp from pc78 to other organisms was not apparent. Population and colony types of culturable bacteria were not significantly affected by the introduction of P. fluorescens pc78 or pc78-48 into tomato rhizosphere. Additionally, terminal restriction fragment length polymorphism profiles were investigated to estimate the influence on the microbial community structure in tomato rhizosphere between non-treated and pc78-48-treated samples. Interestingly, rhizosphere soil treated with strain pc78-48 exhibited a significantly different bacterial community structure compared to that of non-treated rhizosphere soil. Our results suggest that biocontrol bacteria treatment influences microbial community in tomato rhizosphere, while the chromosomally modified biocontrol bacteria may not pose any specific environmental risk in terms of gene transfer. PMID:27147933

  11. APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

    NASA Astrophysics Data System (ADS)

    Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

    2016-08-01

    In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

  12. Electronic and structural properties at the interface between CuPc and graphene

    SciTech Connect

    Tao, Yongsheng; Mao, Hongying; He, Pimo

    2015-01-07

    The electronic and structural properties at Copper phthalocyanine (CuPc)/graphene have been studied using ultraviolet photoemission spectroscopy and first-principles density function theory calculation. The five emission features α, β, γ, δ, and ε originating from the CuPc molecules locate at 1.48, 3.66, 4.98, 6.90, and 9.04 eV, respectively. These features shift in binding energy with the increasing CuPc coverage. The feature α is mostly deriving from Cu 3d orbital with some contributions from C 2p orbital. Further theoretical calculation indicates that the adsorption of CuPc on a top site is the most favorable configuration, and the separation between the adsorbate and graphene is about 3.47 Å. According to the density of states before and after CuPc adsorption, the LUMO of CuPc is slightly occupied, while the Dirac point of graphene slightly shift towards higher energy, suggesting that a small amount of electron transfer from graphene to CuPc upon contact.

  13. Morphological control of CuPc and its application in organic solar cells

    NASA Astrophysics Data System (ADS)

    Hsiao, Yu-Sheng; Whang, Wha-Tzong; Suen, Shich-Chang; Shiu, Jau-Ye; Chen, Chih-Ping

    2008-10-01

    We have prepared organic photovoltaic (OPV) cells possessing an ideal bulk heterojunction (BHJ) structure using the self-assembly of copper phthalocyanine (CuPc) as the donor material and fullerene (C60) as the acceptor. The variable self-assembly behavior of CuPc on a diverse range of substrates (surface energies) allowed us to control the morphology of the interface and the degree of carrier transportation within the active layer. We observed rod-like CuPc structures on indium-tin oxide (ITO), poly(3,4-ethylenedioxythiophene)-poly(4-styrenesulfonate) (PEDOT:PSS) and Au substrates. Accordingly, the interfaces and continuing transport path between CuPc and fullerene domains could be greatly improved due to the ideal BHJ structure. In this paper, we discuss the mechanisms of producing CuPc rod-like films on ITO, PEDOT:PSS and Au. The OPV cell performance was greatly enhanced when a mixture of horizontal and vertical CuPc rods was present on the PEDOT:PSS surfaces, i.e. the power conversion efficiency was 50 times greater than that of the corresponding device featuring a planar CuPc structure.

  14. Morphological control of CuPc and its application in organic solar cells.

    PubMed

    Hsiao, Yu-Sheng; Whang, Wha-Tzong; Suen, Shich-Chang; Shiu, Jau-Ye; Chen, Chih-Ping

    2008-10-15

    We have prepared organic photovoltaic (OPV) cells possessing an ideal bulk heterojunction (BHJ) structure using the self-assembly of copper phthalocyanine (CuPc) as the donor material and fullerene (C(60)) as the acceptor. The variable self-assembly behavior of CuPc on a diverse range of substrates (surface energies) allowed us to control the morphology of the interface and the degree of carrier transportation within the active layer. We observed rod-like CuPc structures on indium-tin oxide (ITO), poly(3,4-ethylenedioxythiophene)-poly(4-styrenesulfonate) (PEDOT:PSS) and Au substrates. Accordingly, the interfaces and continuing transport path between CuPc and fullerene domains could be greatly improved due to the ideal BHJ structure. In this paper, we discuss the mechanisms of producing CuPc rod-like films on ITO, PEDOT:PSS and Au. The OPV cell performance was greatly enhanced when a mixture of horizontal and vertical CuPc rods was present on the PEDOT:PSS surfaces, i.e. the power conversion efficiency was 50 times greater than that of the corresponding device featuring a planar CuPc structure. PMID:21832648

  15. Impact of a Recombinant Biocontrol Bacterium, Pseudomonas fluorescens pc78, on Microbial Community in Tomato Rhizosphere.

    PubMed

    Kong, Hyun Gi; Kim, Nam Hee; Lee, Seung Yeup; Lee, Seon-Woo

    2016-04-01

    Pseudomonas fluorescens pc78 is an effective biocontrol agent for soil-borne fungal diseases. We previously constructed a P43-gfp tagged biocontrol bacteria P. fluorescens pc78-48 to investigate bacterial traits in natural ecosystem and the environmental risk of genetically modified biocontrol bacteria in tomato rhizosphere. Fluctuation of culturable bacteria profile, microbial community structure, and potential horizontal gene transfer was investigated over time after the bacteria treatment to the tomato rhizosphere. Tagged gene transfer to other organisms such as tomato plants and bacteria cultured on various media was examined by polymerase chain reaction, using gene specific primers. Transfer of chromosomally integrated P43-gfp from pc78 to other organisms was not apparent. Population and colony types of culturable bacteria were not significantly affected by the introduction of P. fluorescens pc78 or pc78-48 into tomato rhizosphere. Additionally, terminal restriction fragment length polymorphism profiles were investigated to estimate the influence on the microbial community structure in tomato rhizosphere between non-treated and pc78-48-treated samples. Interestingly, rhizosphere soil treated with strain pc78-48 exhibited a significantly different bacterial community structure compared to that of non-treated rhizosphere soil. Our results suggest that biocontrol bacteria treatment influences microbial community in tomato rhizosphere, while the chromosomally modified biocontrol bacteria may not pose any specific environmental risk in terms of gene transfer.

  16. Impact of a Recombinant Biocontrol Bacterium, Pseudomonas fluorescens pc78, on Microbial Community in Tomato Rhizosphere

    PubMed Central

    Kong, Hyun Gi; Kim, Nam Hee; Lee, Seung Yeup; Lee, Seon-Woo

    2016-01-01

    Pseudomonas fluorescens pc78 is an effective biocontrol agent for soil-borne fungal diseases. We previously constructed a P43-gfp tagged biocontrol bacteria P. fluorescens pc78-48 to investigate bacterial traits in natural ecosystem and the environmental risk of genetically modified biocontrol bacteria in tomato rhizosphere. Fluctuation of culturable bacteria profile, microbial community structure, and potential horizontal gene transfer was investigated over time after the bacteria treatment to the tomato rhizosphere. Tagged gene transfer to other organisms such as tomato plants and bacteria cultured on various media was examined by polymerase chain reaction, using gene specific primers. Transfer of chromosomally integrated P43-gfp from pc78 to other organisms was not apparent. Population and colony types of culturable bacteria were not significantly affected by the introduction of P. fluorescens pc78 or pc78-48 into tomato rhizosphere. Additionally, terminal restriction fragment length polymorphism profiles were investigated to estimate the influence on the microbial community structure in tomato rhizosphere between non-treated and pc78-48-treated samples. Interestingly, rhizosphere soil treated with strain pc78-48 exhibited a significantly different bacterial community structure compared to that of non-treated rhizosphere soil. Our results suggest that biocontrol bacteria treatment influences microbial community in tomato rhizosphere, while the chromosomally modified biocontrol bacteria may not pose any specific environmental risk in terms of gene transfer. PMID:27147933

  17. PC-based PCM (Pulse Code Modulation) telemetry data reduction system hardware

    SciTech Connect

    Simms, D.A.; Butterfield, C.P.

    1990-02-01

    The Solar Energy Research Institute's (SERI) Wind Research Program is using pulse code modulation (PCM) telemetry systems to study horizontal-axis wind turbines. SERI has developed a low-cost PC-based PCM data acquisition system to facilitate quick PCM data analysis in the field. The SERI PC-PCM system consists of AT-compatible hardware boards for decoding and combining PCM data streams and DOS software for control and management of data acquisition. Up to four boards can be installed in a single PC, providing the capability to combine data from four PCM streams direct to disk or memory. This paper describes the SERI PC-PCM system hardware, focusing on the practicality of PC-based PCM data reduction. A related paper highlights our comprehensive PCM data management software program which can be used in conjunction with this hardware to provide full quick-look'' data processing and display. The PC-PCM hardware boards support a subset of the Inter-Range Instrumentation Group (IRIG) PCM standard, designed to synchronize and decommutate NRZ or Bi-Phase L PCM streams in the range of 1 to 800 Kbits/sec at 8 to 12 bits per word and 2 to 64 words per frame. Multiple PCM streams (at various rates) can be combined and interleaved into a contiguous digital time series. Maximum data throughput depends on characteristics of the PC hardware, such as CPU rate and disk access speed. 7 refs., 6 figs., 4 tabs.

  18. Serum-free culture conditions for serial subculture of undifferentiated PC12 cells.

    PubMed

    Ohnuma, Kiyoshi; Hayashi, Yohei; Furue, Miho; Kaneko, Kunihiko; Asashima, Makoto

    2006-03-15

    PC12 cells, a widely used model neuronal cell line, are usually cultured in serum-supplemented medium. This report describes a serum-free medium for the culture of PC12 cells. PC12 cells grown in the two media types had similar growth rates and released dopamine in response to high potassium-induced calcium elevation. However, the levels of dopamine and of dopamine release in cells cultured in the serum-free medium were less than 10% of that in cells cultured in serum-supplemented medium. Dopamine levels recovered within 10 days if cells were returned to serum-supplemented medium, but dopamine release could not be recovered. Nerve growth factor (NGF) induced similar responses in PC12 cells cultured in both media, including phosphorylation of extracellular signal-regulated protein kinases and neurite extension. Transferrin was necessary for survival of neurite-bearing PC12 cells subcultured in serum-free medium and insulin promoted the cells proliferation. Ten days culture with NGF produced a similar increase in neurofilament expression and acetylcholinesterase activity in both media. These results suggest that PC12 in the hormonally defined serum-free media are qualitatively the same as those cultured in serum-supplemented media, and therefore this new culture protocol should enable more precise studies of PC12 cells culture in the absence of confounding unknown factors.

  19. Regulatory site of inorganic pyrophosphatase. Interaction with substrate analogs

    SciTech Connect

    Baikov, A.A.; Pavlov, A.R.; Avaeva, S.M.

    1986-08-10

    The effect of four PP/sub 1/ analogs with the structure PXP (X = N, C), phosphate, and the complex Cr(H/sub 2/O)/sub 4/PP/sub 1/ on the activity of inorganic pyrophosphatase from baker's yeast was studied over a wide range of substrate (Mg-PP/sub 1/) concentrations (lower limit 0.5 ..mu..M). The enzyme activity decreased in the presence of imidodiphosphate, hydroxymethane diphosphonate (PC(OH)P), and P/sub 1/, and a double reciprocal plot of the rate of hydrolysis of Mg-PP/sub 1/ versus its concentration became linear. Small amounts of methane diphosphonate (PCP), ethane-1-hydroxy-1,1-diphosphonate (0.1-1..mu..M), and Cr(H/sub 2/O)/sub 4/PP/sub 1/ (10 ..mu..M) activated the enzyme almost 2-fold by a competitive mechanism. The activation was due to an increase in the affinity of the protein for the activating Mg/sup 2 +/ ion. Ultrafiltration showed that the pyrophosphatase molecule has 2.1 and 3.1 binding sites for PCP and PC(OHP)P, respectively. These results confirm the hypothesis that the enzyme contains a regulatory site whose occupation by PP/sub 1/, P/sub 1/, and substrate analogs increases the affinity of the protein for the activating metal.

  20. A PC-based telemetry system for acquiring and reducing data from multiple PCM streams

    NASA Astrophysics Data System (ADS)

    Simms, D. A.; Butterfield, C. P.

    1991-07-01

    The Solar Energy Research Institute's (SERI) Wind Research Program is using Pulse Code Modulation (PCM) Telemetry Data-Acquisition Systems to study horizontal-axis wind turbines. Many PCM systems are combined for use in test installations that require accurate measurements from a variety of different locations. SERI has found them ideal for data-acquisition from multiple wind turbines and meteorological towers in wind parks. A major problem has been in providing the capability to quickly combine and examine incoming data from multiple PCM sources in the field. To solve this problem, SERI has developed a low-cost PC-based PCM Telemetry Data-Reduction System (PC-PCM System) to facilitate quick, in-the-field multiple-channel data analysis. The PC-PCM System consists of two basic components. First, PC-compatible hardware boards are used to decode and combine multiple PCM data streams. Up to four hardware boards can be installed in a single PC, which provides the capability to combine data from four PCM streams directly to PC disk or memory. Each stream can have up to 62 data channels. Second, a software package written for use under DOS was developed to simplify data-acquisition control and management. The software, called the Quick-Look Data Management Program, provides a quick, easy-to-use interface between the PC and multiple PCM data streams. The Quick-Look Data Management Program is a comprehensive menu-driven package used to organize, acquire, process, and display information from incoming PCM data streams. The paper describes both hardware and software aspects of the SERI PC-PCM system, concentrating on features that make it useful in an experiment test environment to quickly examine and verify incoming data from multiple PCM streams. Also discussed are problems and techniques associated with PC-based telemetry data-acquisition, processing, and real-time display.