Science.gov

Sample records for persons conclusions tf

  1. Conclusions

    NASA Astrophysics Data System (ADS)

    Ahonen, Pasi; Alahuhta, Petteri; Daskala, Barbara; Delaitre, Sabine; Hert, Paul De; Lindner, Ralf; Maghiros, Ioannis; Moscibroda, Anna; Schreurs, Wim; Verlinden, Michiel

    Some say that an increase in security does not necessarily mean a further encroachment on privacy - indeed, security is necessary to protect personal data and our privacy. Networks must be secure, our personal devices, reliable, dependable and trustworthy. But security is a multifaceted term, with many dimensions. We are of the view that an increase in security most likely will encroach upon our privacy in an ambient intelligence world. Surveillance cameras will continue to proliferate. We assume that, whatever the law is, whatever privacy protections government and business say they honour, our telecommunications, e-mails and Internet usage will be monitored to an increasing degree. The same will be true of our interfaces with the world of ambient intelligence.

  2. Personality-Informed Interventions for Healthy Aging: Conclusions From a National Institute on Aging Workgroup

    PubMed Central

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2013-01-01

    We describe two frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is “immutable”, but instead focus on questions of who changes, in what way, why, when, and how. In fact, the notion that personality could be changed was part and parcel of many schools of psychotherapy, which suggested that long term and meaningful change in symptoms could not be achieved without change in relevant aspects of personality. We review intervention research documenting change in personality. Based on an integrative view of personality as a complex system, we describe a “bottom-up” model of change in which interventions to change basic personality processes eventuate in changes at the trait level. A second framework leverages the descriptive and predictive power of personality to tailor individual risk prediction and treatment, as well as refine public health programs, to the relevant dispositional characteristics of the target population. These methods dovetail with and add a systematic and rigorous psychosocial dimension to the personalized medicine and patient-centeredness movements in medicine. In addition to improving health through earlier intervention and increased fit between treatments and persons, cost-effectiveness improvements can be realized by more accurate resource allocation. Numerous examples from the personality, health, and aging literature on Conscientiousness and other traits are provided throughout, and we conclude with a series of recommendations for research in these emerging areas. PMID:23978300

  3. Personality-Informed Interventions for Healthy Aging: Conclusions from a National Institute on Aging Work Group

    ERIC Educational Resources Information Center

    Chapman, Benjamin P.; Hampson, Sarah; Clarkin, John

    2014-01-01

    We describe 2 frameworks in which personality dimensions relevant to health, such as Conscientiousness, can be used to inform interventions designed to promote health aging. First, contemporary data and theory do not suggest that personality is "immutable," but instead focus on questions of who changes, in what way, why, when, and how.…

  4. [Sighted and blind in one person: a case report and conclusions on the psychoneurobiology of vision].

    PubMed

    Waldvogel, B; Ullrich, A; Strasburger, H

    2007-11-01

    We present a patient with dissociative identity disorder (DID) who after 15 years of diagnosed cortical blindness gradually regained sight during psychotherapeutic treatment. At first only a few personality states regained vision, whereas others remained blind. This was confirmed by electrophysiological measurement, in which visual evoked potentials (VEP) were absent in the blind personality states but normal and stable in the seeing states. The switch between these states could happen momentarily. As a neural basis of such psychogenic blindness, we assume a top-down modulation of activity in the primary visual pathway, possibly at the level of the thalamus or the primary visual cortex. Therefore VEPs do not allow distinction of psychogenic blindness from organic disruption of the visual pathway. In summary, psychogenic blindness seems to suppress visual information at an early neural stage.

  5. Debates to personal conclusion in peripheral nerve injury and reconstruction: A 30-year experience at Chang Gung Memorial Hospital.

    PubMed

    Chuang, David Chwei-Chin

    2016-01-01

    Significant progress has been achieved in the science and management of peripheral nerve injuries over the past 40 years. Yet there are many questions and few answers. The author, with 30 years of experience in treating them at the Chang Gung Memorial Hospital, addresses debates on various issues with personal conclusions. These include: (1) Degree of peripheral nerve injury, (2) Timing of nerve repair, (3)Technique of nerve repair, (4) Level of brachial plexus injury,(5) Level of radial nerve injury,(6) Traction avulsion amputation of major limb, (7) Proximal Vs distal nerve transfers in brachial plexus injuries and (8) Post paralysis facial synkinesis.

  6. Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release.

    PubMed

    Ettelaie, Camille; Collier, Mary E W; Featherby, Sophie; Greenman, John; Maraveyas, Anthony

    2016-11-01

    Restriction of tissue factor (TF) activity at the cell surface and TF release are critical for prevention of excessive coagulation. This study examined the regulation of TF dephosphorylation and its release through ubiquitination. A plasmid containing the sequence to express the tandem protein TF-tGFP was mutated to include an arginine-substitution at Lys255 within TF. MDA-MB-231 cell line, and HCAEC endothelial cells were transfected and subsequently activated with PAR2-agonist peptide. The wild-type and mutant TF-tGFP were immunoprecipitated from the cell lysates and the ubiquitination and phosphorylation state of TF examined. Analysis of the proteins showed that arginine-substitution of Lys255 within TF prevented its ubiquitination while the wild-type TF-tGFP was oligoubiquitinated. The TF-associated oligoubiquitin chain was estimated to contain up to 4 ubiquitin units, with the linkage formed between Lys63 of one ubiquitin unit, and the C-terminus of the next unit. The Lys255→Arg substitution of TF-tGFP prolonged the phosphorylation of Ser253 within TF, compared to the wild-type TF-tGFP, lengthened the presence of TF-tGFP at the cell surface and extended the duration of TF-tGFP release from cells following PAR2 activation. A biotinylated 19-mer peptide corresponding to the C-terminus of TF (TFc) was used as substrate to show that the ubiquitination of TF was mediated by the Ube2D family of E2-enzymes and involved Mdm2. Moreover, double-phosphorylation of TFc was prerequisite for ubiquitination, with subsequent dephosphorylation of Ser253 by phosphatase PP2A. In conclusion, oligoubiquitination of Lys255 within TF permits PP2A to bind and dephosphorylate Ser253 and occurs to terminate TF release and contain its activity.

  7. Sweet Conclusion

    ERIC Educational Resources Information Center

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  8. FLOWTRAN-TF code benchmarking

    SciTech Connect

    Flach, G.P.

    1990-12-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss Of Coolant Accident (LOCA). A description of the code is given by Flach et al. (1990). This report provides benchmarking results for the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit (Smith et al., 1990a; 1990b). Individual constitutive relations are benchmarked in Sections 2 through 5 while in Sections 6 and 7 integral code benchmarking results are presented. An overall assessment of FLOWTRAN-TF for its intended use in computing the ECS power limit completes the document.

  9. FLOWTRAN-TF code description

    SciTech Connect

    Flach, G.P.

    1990-12-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  10. FLOWTRAN-TF code description

    SciTech Connect

    Flach, G.P.

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  11. FLOWTRAN-TF software design

    SciTech Connect

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III.

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 Software Design and Implementation'' in the 1Q34 manual.

  12. FLOWTRAN-TF software design

    SciTech Connect

    Aleman, S.E.; Flach, G.P.; Hamm, L.L.; Lee, S.Y.; Smith, F.G. III

    1993-02-01

    FLOWTRAN-TF was created to analyze an individual Mk22 fuel assembly during a large break Loss Of Coolant Accident (LOCA) scenario involving the Savannah River Site K-reactor after the initial few seconds of the transient. During the initial few seconds reactor cooling is limited by the static or Ledinegg flow instability phenomenon. The predecessor FLOWTRAN code was developed to analyze this portion of a LOCA. In the several seconds following the break, a significant fraction of the reactor coolant inventory leaks out the break, Emergency Cooling System (ECS) flow is initiated, and air enters the primary coolant circulation loops. Reactor fuel assemblies are cooled by a low flowrate air-water downflow. Existing commercial nuclear industry thermal-hydraulic codes were judged inadequate for detailed modeling of a Mk22 fuel assembly because the application involves a ribbed annular geometry, low pressure, downflow and an air-water mixture. FLOWTRAN-TF is a two-phase thermal-hydraulics code of similar technology to existing commercial codes such as RELAP and TRAC but customized for Savannah River Site applications. The main features and capabilities of FLOWTRAN-TF are detailed Mk22 fuel assembly ribbed annular geometry; conjugate heat transfer; detailed neutronic power distribution; three-dimensional heat conduction in Mk22 fuel and target tubes; two-dimensional coolant flow in channels (axial, azimuthal); single-phase and/or two-phase fluid (gas, liquid and/or gas-liquid); two-component (air, water); constitutive models applicable to low pressure air-water downflow in ribbed annular channels. The design of FLOWTRAN-TF is described in detail in this report which serves as the Software Design Report in accordance with Quality Assurance Procedure IV-4, Rev. 0 ``Software Design and Implementation`` in the 1Q34 manual.

  13. TF — EDRN Public Portal

    Cancer.gov

    TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.

  14. Functional characterization of the alphavirus TF protein.

    PubMed

    Snyder, Jonathan E; Kulcsar, Kirsten A; Schultz, Kimberly L W; Riley, Catherine P; Neary, Jacob T; Marr, Scott; Jose, Joyce; Griffin, Diane E; Kuhn, Richard J

    2013-08-01

    Alphavirus dogma has long dictated the production of a discrete set of structural proteins during infection of a cell: capsid, pE2, 6K, and E1. However, bioinformatic analyses of alphavirus genomes (A. E. Firth, B. Y. Chung, M. N. Fleeton, and J. F. Atkins, Virol. J. 5:108, 2008) suggested that a ribosomal frameshifting event occurs during translation of the alphavirus structural polyprotein. Specifically, a frameshift event is suggested to occur during translation of the 6K gene, yielding production of a novel protein, termed transframe (TF), comprised of a C-terminal extension of the 6K protein in the -1 open reading frame (ORF). Here, we validate the findings of Firth and colleagues with respect to the production of the TF protein and begin to characterize the function of TF. Using a mass spectrometry-based approach, we identified TF in purified preparations of both Sindbis and Chikungunya virus particles. We next constructed a panel of Sindbis virus mutants with mutations which alter the production, size, or sequence of TF. We demonstrate that TF is not absolutely required in culture, although disrupting TF production leads to a decrease in virus particle release in both mammalian and insect cells. In a mouse neuropathogenesis model, mortality was <15% in animals infected with the TF mutants, whereas mortality was 95% in animals infected with the wild-type virus. Using a variety of additional assays, we demonstrate that TF retains ion-channel activity analogous to that of 6K and that lack of production of TF does not affect genome replication, particle infectivity, or envelope protein transit to the cell surface. The TF protein therefore represents a previously uncharacterized factor important for alphavirus assembly.

  15. The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise.

    PubMed

    Tian, Ye; Zhao, Jiexiu; Zhao, Binxiu; Gao, Qi; Xu, Jincheng; Liu, Dongsen

    2012-06-01

    Currently, it is unclear which index of haematological parameters could be used to most easily monitor iron deficiency during endurance training. To address this question, 16 male Wistar rats were randomly assigned to two groups: a sedentary group (n = 8) and an exercised group (n = 8). Initially, animals in the exercise group started running on a treadmill at a rate of 30 m/min, on a 0% grade, for 1 min/session. Running time was gradually increased by 2 min/day. The training plan was one session per day during the initial 2 weeks and two sessions per day during the third to ninth week. At the end of the 9-week experiment, we analysed the blood of the experimental animals for haemoglobin levels, erythrocyte numbers, haematocrit, serum iron levels, total iron binding capacity, transferrin saturation, serum ferritin levels and soluble transferrin receptor (sTfR) levels, and we calculated the ratio of sTfR/ferritin. Erythrocyte numbers, haemoglobin levels and haematocrit values were decreased after 9 weeks of exercise, but sTfR and sTfR/ferritin values were increased (P < 0.01 or P < 0.05). The training regime significantly increased TfR mRNA levels in the bone marrow cells of the exercised rats compared with the sedentary group (1.8 ± 0.5 vs. 1.1 ± 0.2, P < 0.01). These results revealed a significant correlation between TfR levels in the bone marrow cells and the ratio of sTfR/ferritin (r = 0.517; P < 0.01) and sTfR levels (r = 0.206; P < 0.05) in sedentary and exercised rats. In conclusion, we show that sTfR indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training.

  16. FLOWTRAN-TF code description. Revision 1

    SciTech Connect

    Flach, G.P.

    1991-09-01

    FLOWTRAN-TF is a two-component (air-water), two-phase thermal-hydraulics code designed for performing accident analyses of SRS reactor fuel assemblies during the Emergency Cooling System (ECS) phase of a Double Ended Guillotine Break (DEGB) Loss of Coolant Accident (LOCA). This report provides a brief description of the physical models in the version of FLOWTRAN-TF used to compute the Recommended K-Reactor Restart ECS Power Limit. This document is viewed as an interim report and should ultimately be superseded by a comprehensive user/programmer manual. In general, only high level discussions of governing equations and constitutive laws are presented. Numerical implementation of these models, code architecture and user information are not generally covered. A companion document describing code benchmarking is available.

  17. TF-34 turbofan quiet engine study

    NASA Technical Reports Server (NTRS)

    Edkins, D. P.; Hirschkron, R.; Lee, R.

    1972-01-01

    A study of high bypass turbofan engines in heavily sound-suppressed nacelles based on the TF-34 engine. The four-engine noise objective was 95 PNdb at four locations typical of takeoff and landing. Three engines were studied; these had fan pressure ratios, bypass ratios, and fan tip speeds respectively of 1.48/6.5/404 m/sec (1327 ft/sec), 1.25/13/305 (1000), 1.25/13/366(1200). The bypass 13 engines had a variable pitch fan, direct- and gear-driven. Noise suppressive treatment was identified which met 95 PNdb objective except for sideline liftoff at 6.5 bypass, full power, which was 2 PNdb noisier; at 90% power, 95 PNdb was achieved.

  18. FLOWTRAN-TF v1. 2 source code

    SciTech Connect

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III.

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  19. FLOWTRAN-TF v1.2 source code

    SciTech Connect

    Aleman, S.E.; Cooper, R.E.; Flach, G.P.; Hamm, L.L.; Lee, S.; Smith, F.G. III

    1993-02-01

    The FLOWTRAN-TF code development effort was initiated in early 1989 as a code to monitor production reactor cooling systems at the Savannah River Plant. This report is a documentation of the various codes that make up FLOWTRAN-TF.

  20. A-10/TF34 Turbine Engine Monitoring System (TEMS)

    NASA Technical Reports Server (NTRS)

    Christopher, R. G.

    1981-01-01

    The hardware and software development of the A-10/TF34 turbine engine monitoring system (TEMS) is described. The operation and interfaces of the A-10/TF34 TEMS hardware are discussed with particular emphasis on function, capabilities, and limitations. The TEMS data types are defined and the various data acquisition modes are explained. Potential data products are also discussed.

  1. Conclusion

    NASA Astrophysics Data System (ADS)

    Ivancevic, Vladimir G.; Reid, Darryn J.

    2015-11-01

    It is often held that things should always be made simple, which presumes that either that they can always be made simple or that all the jetisoned logic doesn't matter anyway. Alledgedly, anything should be explainable so that anyone can understand it. Don't get bogged down in dreary details. It should be effortless for the reader: low-dimensional systems exhibit complex behaviour while high-dimensional systems exhibit simple behaviour (to return to our prolegomonal opening), competition is a universal solution, demand must increase as price falls, and everything under the sun neatly fits a power law. Or so the story goes...

  2. Conclusions

    NASA Astrophysics Data System (ADS)

    Binder, P.-M.; Smith, K.

    If you made it to this point, this is what we have tried to offer you: a view of language like no other book has provided before. It is quite possible that this is one of very few books you have read on the subject; it could even be your first. Chances are that those you have read were written for a general audience. Some of them are very good, but they usually try to push a particular viewpoint of their author. Or you may have followed an introductory linguistics course at the university level. Such courses, and their textbooks, focus on technical aspects of the subject: the details of theories of phonology, syntax, semantics and so on. Knowledge of all of these areas is absolutely necessary for a deep understanding of the subject. But both single-author general books and technical textbooks have the same shortcoming: they do not give the reader a broad and complete account of how language works.

  3. Conclusion

    NASA Technical Reports Server (NTRS)

    Arnold, Steven M.; Wong, Terry T.

    2011-01-01

    This compilation of papers in this book represents approximately half of the works discussed at the MS&T 2010 symposium entitled Tools, Models, Databases, and Simulation Tools Developed and Needed to Realize the Vision of Integrated Computational Materials Engineering at Materials Science & Technology wherein five sessions comprised of 33 presentations was organized. The goal of the symposium was two fold To provide a forum in which current state-of-the-art methods for ICME (e.g., information informatics, experimentation, and modeling) could be openly discussed and critiqued by not only materials scientist but also structural engineers/researchers, component designers, industrial leaders and government program managers. To leave the symposium and in particular the panel discussion with a clear idea of the gaps and barriers (both technical, cultural and economical) that must be addressed in order for ICME to fully succeed. The organizers felt that these goals were met, as particularly evident by the standing room only attendance during a lively panel discussion session at the end of the Symposium. However it is the firm belief of the editors of this book that this symposium was merely a start in the right direction, and that subsequent conferences/symposium (e.g., First World Congress on Integrated Computational Materials Engineering to be held July 10-14, 2011 at Seven Springs Mountain Resort in Pennsylvania) must work hard to ensure that a truly diverse, multidisciplinary, community of researchers and practitioners are present and have ample opportunity for interaction. This will ensure that a proper balance between push and pull disciplines and technologies is maintained so that this emerging focus area, Integrated Computational Materials Engineering (ICME), has the greatest potential for success and impact on "system-level" payoffs. Similarly, a pro-active approach is required to reform historical modes of operation in industry, government and the academic sectors so as to facilitate multidisciplinary collaboration and to clearly articulate the vision and scope of ICME.

  4. Aircraft emissions characterization: TF41-a2, TF30-p103, and TF30-p109 engines. Final report, December 1985-March 1987

    SciTech Connect

    Spicer, C.W.; Holdren, M.W.; Miller, S.E.; Smith, D.L.; Smith, R.N.

    1987-12-01

    Assessment of the environmental impact of aircraft operations is required by Air Force regulations. This program was undertaken with the aim of quantifying the gaseous and particulate emissions associated with three Air Force turbine engines. These engines were TF41-A2, TF30-P103, and TF30-P109. The emissions tests were carried out, using a test cell Tinker AFP, Oklahoma City, OK. All tests employed JP-4 as the fuel, and fuel samples were characterized by standard tests and analyzed for composition. Emissions were measured at power settings of idle, 30%, 75%, 100%, and afterburner (where appropriate). Measurements were made of detailed organic composition, CO, CO/sub 2/, NO, NOx, smoke number, particle concentration, and particle-size distribution. A multiport sampling rake was used to sample the exhaust, and heated Teflon tubing was used to transfer exhaust to the monitoring instrumentation. Measured and calculated fuel/air ratios were compared to assure representative sampling of the exhaust.

  5. TF ripple loss of alpha particles in TFTR DT experiments

    SciTech Connect

    Redi, M.H.; Budny, R.V.; Darrow, D.S.

    1995-08-01

    Quantitative evaluation of TF ripple loss of DT alpha particles is a central issue for reactor design because of potentially severe first wall heat load problems. DT experiments on TFTR allow experimental measurements to be compared to modeling of the underlying alpha physics, with code validation an important goal. Modeling of TF ripple loss of alphas in TFTR now includes neoclassical calculations of alpha losses arising from first orbit loss, stochastic ripple diffusion, ripple trapping and collisional effects. Recent Hamiltonian coordinate guiding center code (ORBIT) simulations for TFTR have shown that collisions enhance the stochastic TF ripple losses at TFTR. A faster way to simulate experiment has been developed and is discussed here which uses a simple stochastic domain model for TF ripple loss within the TRANSP analysis code.

  6. BOREAS TF-9 SSA-OBS Branch Level Flux Data

    NASA Technical Reports Server (NTRS)

    Rayment, Mark B.; Jarvis, Paul G.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-9 team collected data that describe carbon dioxide and water vapor fluxes from foliage at the BOREAS SSA-OBS site from 07-April through 23-November-1996. The data are available in tabular ASCII files.

  7. Comparative Evaluation of Tubex TF (Inhibition Magnetic Binding Immunoassay) for Typhoid Fever in Endemic Area

    PubMed Central

    Khanna, Menka; Gill, Karamjit Singh

    2015-01-01

    Background Typhoid fever remains a significant health problem in endemic countries like India. Various serological tests for the diagnosis of typhoid fever are available commercially. We assessed the usefulness of rapid test based on magnetic particle separation to detect Immunoglobulin against Salmonella typhi O9 lipopolysaccharide. Aim Aim of this study was to compare the sensitivity and specificity of widal test, typhidot and tubex TF test for the diagnosis of typhoid fever in an endemic country like India. Materials and Methods Serum samples collected from 50 patients of typhoid fever, 50 patients of non typhoid fever and 100 normal healthy individuals residing in Amritsar were subjected to widal test, typhidot test and tubex TF test as per manufacturer’s instructions. Data collected was assessed to find sensitivity and specificity of these tests in an endemic area. Results Significant widal test results were found positive in 68% of patients of typhoid fever and only 4% of non typhoid fever patients. Typhidot (IgM or IgG) was positive in 72% of typhoid fever patients and 10% and 6% in non typhoid fever and normal healthy individuals respectively. Tubex TF showed higher sensitivity of 76% and specificity of 96-99% which was higher than typhidot and comparable to widal test. Conclusion This was the first evaluation of rapid tubex TF test in northern India. In countries which can afford high cost of test, tubex TF should be recommended for the diagnosis in acute stage of the disease in clinical setting. However, there is urgent need for a highly specific and sensitive test for the diagnosis of typhoid fever in clinical settings in endemic areas. PMID:26676104

  8. The Influence of Visibility, Cloud Ceiling, Financial Incentive, and Personality Factors on General Aviation Pilots’ Willingness to Take Off Into Marginal Weather, Part 1: The Data and Preliminary Conclusions

    DTIC Science & Technology

    2005-04-01

    National transportation statistics, 2001. Washington, DC: U.S. Department of Transportation. Eysenck , H.J., & Eysenck , S.B.G. (1964). Eysenck Per...sonality Inventory. San Diego, CA: Educational and Industrial Testing Service. Eysenck , H.J., & Eysenck , M.W. (1985). Personality and individual...differences: A natural science approach. New York: Plenum. Eysenck , H.J., & Eysenck , S.B.G. (1975). Manual of the Eysenck Personality Questionnaire

  9. TF Inner Leg Space Allocation for Pilot Plant Design Studies

    SciTech Connect

    Peter H. Titus and Ali Zolfaghari

    2012-09-06

    A critical design feature of any tokamak is the space taken up by the inner leg of the toroidal field (TF) coil. The radial build needed for the TF inner leg, along with shield thickness , size of the central solenoid and plasma minor radius set the major radius of the machine. The cost of the tokamak core roughly scales with the cube of the major radius. Small reductions in the TF build can have a big impact on the overall cost of the reactor. The cross section of the TF inner leg must structurally support the centering force and that portion of the vertical separating force that is not supported by the outer structures. In this paper, the TF inner leg equatorial plane cross sections are considered. Out-of- Plane (OOP) forces must also be supported, but these are largest away from the equatorial plane, in the inner upper and lower corners and outboard sections of the TF coil. OOP forces are taken by structures that are not closely coupled with the radial build of the central column at the equatorial plane. The "Vertical Access AT Pilot Plant" currently under consideration at PPPL is used as a starting point for the structural, field and current requirements. Other TF structural concepts are considered. Most are drawn from existing designs such as ITER's circular conduits in radial plates bearing on a heavy nose section, and TPX's square conduits in a case, Each of these concepts can rely on full wedging, or partial wedging. Vaulted TF coils are considered as are those with some component of bucking against a central solenoid or bucking post. With the expectation that the pilot plant will be a steady state machine, a static stress criteria is used for all the concepts. The coils are assumed to be superconducting, with the superconductor not contributing to the structural strength. Limit analysis is employed to assess the degree of conservatism in the static criteria as it is applied to a linear elastic stress analysis. TF concepts, and in particular the PPPL AT

  10. BOREAS TF-11 Biomass Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains plant cover, standing crop of plant biomass, and estimated net primary productivity at each chamber site at the end of the 1994 field season. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  11. BOREAS TF-11 Decomposition Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains decomposition rates of a standard substrate (wheat straw) across treatments. The measurements were conducted in 1994 as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  12. Prediction of TF target sites based on atomistic models of protein-DNA complexes

    PubMed Central

    Angarica, Vladimir Espinosa; Pérez, Abel González; Vasconcelos, Ana T; Collado-Vides, Julio; Contreras-Moreira, Bruno

    2008-01-01

    Background The specific recognition of genomic cis-regulatory elements by transcription factors (TFs) plays an essential role in the regulation of coordinated gene expression. Studying the mechanisms determining binding specificity in protein-DNA interactions is thus an important goal. Most current approaches for modeling TF specific recognition rely on the knowledge of large sets of cognate target sites and consider only the information contained in their primary sequence. Results Here we describe a structure-based methodology for predicting sequence motifs starting from the coordinates of a TF-DNA complex. Our algorithm combines information regarding the direct and indirect readout of DNA into an atomistic statistical model, which is used to estimate the interaction potential. We first measure the ability of our method to correctly estimate the binding specificities of eight prokaryotic and eukaryotic TFs that belong to different structural superfamilies. Secondly, the method is applied to two homology models, finding that sampling of interface side-chain rotamers remarkably improves the results. Thirdly, the algorithm is compared with a reference structural method based on contact counts, obtaining comparable predictions for the experimental complexes and more accurate sequence motifs for the homology models. Conclusion Our results demonstrate that atomic-detail structural information can be feasibly used to predict TF binding sites. The computational method presented here is universal and might be applied to other systems involving protein-DNA recognition. PMID:18922190

  13. Personalization.

    ERIC Educational Resources Information Center

    Shore, Rebecca Martin

    1996-01-01

    Describes how a typical high school in Huntington Beach, California, curbed disruptive student behavior by personalizing the school experience for "problem" students. Through mostly volunteer efforts, an adopt-a-kid program was initiated that matched kids' learning styles to adults' personality styles and resulted in fewer suspensions…

  14. BOREAS TF-1 SSA-OA Soil Characteristics Data

    NASA Technical Reports Server (NTRS)

    Black, T. Andrew; Chen, Z; Nesic, Z.; Hall, Forrest G. (Editor); Papagno, Andrea (Editor)

    2000-01-01

    The BOREAS TF-1 team collected several data sets in support of its efforts to characterize and interpret soil information at the SSA-OA tower site in 1994 as part of BOREAS. Data sets collected include soil respiration, temperature, moisture, and gravimetric data. The data are stored in tabular ASCII format.

  15. BOREAS TF-11 SSA-Fen Leaf Gas Exchange Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. This data set contains single-leaf gas exchange data from the SSA-Fen site during 1994 and 1995. These leaf gas exchange properties were measured for the dominant vascular plants using portable gas exchange systems. The data are stored in tabular ASCII files.

  16. TF41 Engine Fan Disk Seeded Fault Crack Propagation Test

    NASA Technical Reports Server (NTRS)

    Lewicki, David G.

    2003-01-01

    Uncontained engine failures, although rare in occurrence, can have a catastrophic effect on aircraft performance and safety. Engine disk cracks can eventually lead to these type of failures. A number of techniques to detect engine disk cracks have been developed in recent years. However, these technologies have only been validated by disk spin pit tests, not actual engine tests. Due to this, a project was established to perform seeded fault engine tests on a TF41 engine disk fan. A defect was machined in the first stage fan disk of a TF41 engine. The disk was run in a spin pit to initiate a crack. Once initiated, the disk was run in an actual engine test facility. The engine was cycled by a number of start and stops with the goal of propagating the crack to disk burst through low cycle fatigue. Various crack detection techniques were installed on the engine and run real-time during the test to validate their abilities to detect disk cracks. These techniques were based on methods such as change in mass imbalance using vibration or shaft displacement, change in blade position, acoustic emission, and torsional resonance. At the completion of 4474 test cycles, the crack in the TF41 disk was determined to have grown approximately 0.025 inches. This was far less the predicted crack growth based on a fracture mechanics analysis and finite element stress analysis.

  17. Conclusions and Recommendations. Chapter 37

    NASA Technical Reports Server (NTRS)

    Lamar, John E.; Hummel, Dietrich

    2009-01-01

    This chapter provides a brief wrap-up of the task group report and focuses on the overall conclusions and recommendations for future work for the CAWAPI and VFE-2 facets beyond the task group. The overall conclusion is that the Technology Readiness Level (TRL) of CFD solvers has been improved in predicting the flow-physics of vortex-dominated flows during the work of the task group, by having flight and wind-tunnel data available for comparison. Moreover, like all good scientific studies, this task group has identified flight conditions on the F-16XL airplane or wind-tunnel test conditions for a specific leading-edge radius on the 65 delta-wing model where the TRL still needs to be increased.

  18. Tensile tests of ITER TF conductors jacket materials

    NASA Astrophysics Data System (ADS)

    Anashkin, O. P.; Kеilin, V. E.; Krivykh, A. V.; Diev, D. N.; Dinisilov, A. S.; Shcherbakov, V. I.; Tronza, V. I.

    2012-06-01

    The set of very tough requirements has been formulated for TF jacket materials with extremely high plasticity at liquid helium temperature. The stainless steel 316LN-IG is recommended to be used for TF jacket tubes. Samples of 316LN-IG tubes (whole tubes and sub-size samples) made of the material from the same electro slag remelt have been tested in different conditions - as received tubes and tubes after prescribed compaction, 2.5% deformation at room temperature and heat treatment at 650 0C, 200 hours. The tensile tests were carried out at room, liquid nitrogen and liquid helium temperatures down to 4.2 K, meeting corresponding ASME and ASTM requirements. The low temperature testing devices are described. The tests results for sub-size samples and whole tubes show that the latter tests are considerably more representative and important for butt weld qualification at LHe temperature. It was observed that the ferromagnetic properties of all samples and especially of butt welds increase with lowering the temperature and increasing the degree of deformation. At LHe temperature a non-uniform and highly localized serrated deformations were observed.

  19. Short initial length quench on CICC of ITER TF coils

    SciTech Connect

    Nicollet, S.; Ciazynski, D.; Duchateau, J.-L.; Lacroix, B.; Bessette, D.; Rodriguez-Mateos, F.; Coatanea-Gouachet, M.; Gauthier, F.

    2014-01-29

    Previous quench studies performed for the International Thermonuclear Experimental Reactor (ITER) Toroidal Field (TF) Coils have led to identify two extreme families of quench: first 'severe' quenches over long initial lengths in high magnetic field, and second smooth quenches over short initial lengths in low field region. Detailed analyses and results on smooth quench propagation and detectability on one TF Cable In Conduit Conductor (CICC) with a lower propagation velocity are presented here. The influence of the initial quench energy is shown and results of computations with either a Fast Discharge (FD) of the magnet or without (failure of the voltage quench detection system) are reported. The influence of the central spiral of the conductor on the propagation velocity is also detailed. In the cases of a regularly triggered FD, the hot spot temperature criterion of 150 K (with helium and jacket) is fulfilled for an initial quench length of 1 m, whereas this criterion is exceed (Tmax ≈ 200 K) for an extremely short length of 5 cm. These analyses were carried out using both the Supermagnet(trade mark, serif) and Venecia codes and the comparisons of the results are also discussed.

  20. High frequency dynamic engine simulation. [TF-30 engine

    NASA Technical Reports Server (NTRS)

    Schuerman, J. A.; Fischer, K. E.; Mclaughlin, P. W.

    1977-01-01

    A digital computer simulation of a mixed flow, twin spool turbofan engine was assembled to evaluate and improve the dynamic characteristics of the engine simulation to disturbance frequencies of at least 100 Hz. One dimensional forms of the dynamic mass, momentum and energy equations were used to model the engine. A TF30 engine was simulated so that dynamic characteristics could be evaluated against results obtained from testing of the TF30 engine at the NASA Lewis Research Center. Dynamic characteristics of the engine simulation were improved by modifying the compression system model. Modifications to the compression system model were established by investigating the influence of size and number of finite dynamic elements. Based on the results of this program, high frequency engine simulations using finite dynamic elements can be assembled so that the engine dynamic configuration is optimum with respect to dynamic characteristics and computer execution time. Resizing of the compression systems finite elements improved the dynamic characteristics of the engine simulation but showed that additional refinements are required to obtain close agreement simulation and actual engine dynamic characteristics.

  1. Fuel effects on the TF30 engine (Alternate test procedure)

    SciTech Connect

    Karpovich, P.A.; Musters, A.I.

    1984-09-01

    The objective of the Alternate Test Procedure (ATP) is to develop the capability to qualify new fuels for Navy aircraft use with a minimum of testing. The effect of fuel composition and properties on engine performance and component life has been shown to vary significantly from one engine configuration to another. The PandWA approach to the ATP has been to define fuel effects on the TF30 engine and then apply the methodology to other engines of interest to the Navy. Investigations of the TF30 conducted under the ATP Program and other Navy and Air Force Contracts have produced one of the most complete fuel effect characterizations available for any gas turbine engine. Major fuel effects which have been quantified are the relationships of lubricity to main fuel control reliability, viscosity and volatility to main burner and augmentor ignition limits, and hydrogen content to smoke and combustor life. The effects of fuel properties and composition on combustion efficiency and elastomeric seal life were found to be of secondary importance. Remaining uncertainties are the effects of fuel properties on turbine life and fuel nozzle fouling rate.

  2. [SENTIERI Project: discussion and conclusions].

    PubMed

    Pirastu, Roberta; Ricci, Paolo; Comba, Pietro; Bianchi, Fabrizio; Biggeri, Annibale; Conti, Susanna; Fazzo, Lucia; Forastiere, Francesco; Iavarone, Ivano; Martuzzi, Marco; Musmeci, Loredana; Pasetto, Roberto; Zona, Amerigo; Crocetti, Emanuele

    2014-01-01

    showing the increase, considering latency and the length of the observation period. Of further interest are results relating to diseases of the urinary tract such as kidney failure in the NPCSs of Basso bacino del fiume Chienti, Taranto, Milazzo and Priolo. Overall, the results discussed above are consistent with the previous findings pertaining to mortality for 1995-2002. The present analysis also introduces a new element - the study of cancer incidence and hospital discharges - which can tell us a great deal about diseases with high survival rates or non lethal ones. The first is the case of thyroid cancer, which presents increases in both databases and for both genders in a number of NPCSs (Brescia-Caffaro, Laghi di Mantova, Milazzo, Sassuolo- Scandiano and Taranto). The study of cancer incidence and hospital discharges also revealed cancer excesses for melanoma, breast cancer and non Hodgkin lymphoma in Brescia-Caffaro NPCS where PCBs (Polychlorinated biphenyl) are the site's main pollutant. PCBs, according to the 2013 evaluation of the International Agency for Research on Cancer, are ascertained human carcinogens for melanoma and probable carcinogens for breast cancer and non-Hodgkin lymphoma. The results pertaining to cancer incidence in the 17 NPCSs can also be presented using rankings by area or disease analyzed by a multivariate hierarchical Bayesian model. These rankings reveal an overlapping of credibility intervals, such that it is not possible to speak of a limited number of cancer sites or of certain NPCSs as being particularly affected. Every NPCS, therefore, must be considered individually and ordering them by ranking of cancer incidence wouldn't be appropriate. Data collected concerning some of the NPCSs in the context of the SENTIERI Project is so conclusive that remediation measures can immediately be put in place. This is the case in the Biancavilla and Brescia-Caffaro NPCSs. A similar conclusion can be drawn for complex locations such as Taranto

  3. The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

    PubMed

    Camargos, Thalita S; Bosmans, Frank; Rego, Solange C; Mourão, Caroline B F; Schwartz, Elisabeth F

    2015-01-01

    We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function.

  4. The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening

    PubMed Central

    Camargos, Thalita S.; Bosmans, Frank; Rego, Solange C.; Mourão, Caroline B. F.; Schwartz, Elisabeth F.

    2015-01-01

    We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Tf2 shifts hNav1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Nav channels (Nav1.1-1.2; Nav1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Nav channel function. PMID:26083731

  5. Co-modification of class B genes TfDEF and TfGLO in Torenia fournieri Lind. alters both flower morphology and inflorescence architecture.

    PubMed

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Nakayama, Masayoshi; Aida, Ryutaro; Ohtsubo, Norihiro

    2014-10-01

    The class B genes DEFICIENS (DEF)/APETALA3 (AP3) and GLOBOSA (GLO)/PISTILLATA (PI), encoding MADS-box transcription factors, and their functions in petal and stamen development have been intensely studied in Arabidopsis and Antirrhinum. However, the functions of class B genes in other plants, including ornamental species exhibiting floral morphology different from these model plants, have not received nearly as much attention. Here, we examine the cooperative functions of TfDEF and TfGLO on floral organ development in the ornamental plant torenia (Torenia fournieri Lind.). Torenia plants co-overexpressing TfDEF and TfGLO showed a morphological alteration of sepals to petaloid organs. Phenotypically, these petaloid sepals were nearly identical to petals but had no stamens or yellow patches like those of wild-type petals. Furthermore, the inflorescence architecture in the co-overexpressing torenias showed a characteristic change in which, unlike the wild-types, their flowers developed without peduncles. Evaluation of the petaloid sepals showed that these attained a petal-like nature in terms of floral organ phenotype, cell shape, pigment composition, and the expression patterns of anthocyanin biosynthesis-related genes. In contrast, torenias in which TfDEF and TfGLO were co-suppressed exhibited sepaloid petals in the second whorl. The sepaloid petals also attained a sepal-like nature, in the same way as the petaloid sepals. The results clearly demonstrate that TfDEF and TfGLO play important cooperative roles in petal development in torenia. Furthermore, the unique transgenic phenotypes produced create a valuable new way through which characteristics of petal development and inflorescence architecture can be investigated in torenia.

  6. Simultaneous immunization of mice with Omp31 and TF provides protection against Brucella melitensis infection.

    PubMed

    Ghasemi, Amir; Jeddi-Tehrani, Mahmood; Mautner, Josef; Salari, Mohammad Hossein; Zarnani, Amir-Hassan

    2015-10-13

    Brucella vaccines consisting of live attenuated Brucella strains are currently used in livestock, but safety concerns preclude their application in humans. Subunit vaccines have recently emerged as safe and efficacious alternatives in both humans and animals. In this study, subunit vaccines were developed that consisted of a recombinant outer membrane protein (rOmp31) and the trigger factor chaperone protein (rTF) of Brucella melitensis, either alone or in combination. BALB/c mice that were immunized with rOmp31+rTF showed comparable but slightly higher TF-specific IgG1 and IgG2a antibodies as compared to mice with rTF alone. Indeed, mice given this combination had titers of rOmp31-specific antibodies similar to those immunized with rOmp31 alone. In lymphocyte reactivation experiments, the splenocytes of immunized mice, whether given either of these antigens alone or as a cocktail, exhibited a strong antigen-specific recall proliferative response and expressed high amounts of IFN-γ, IL-12, IL-10 and IL-6. Both rTF and rTF+rOmp31 vaccinated mice exhibited significantly higher CD4 and CD8 levels compared to the PBS group. The combination of rOmp31 and rTF provided protection against B. melitensis infection comparable to that of vaccine strain Rev.1. In comparison to rTF alone, combination of rTF and rOmp31 caused only a slight increase in protection level. Although combination of rTF and rOmp31 caused a non-significant increase in IFN-γ induction, antibody level, proliferation index and CD4 and CD8 frequencies compared to rTF alone, its cumulative effects on aforesaid parameters may be viewed as a better efficacy.

  7. Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T.

    PubMed

    Hernández-González, Ismael L; Olmedo-Álvarez, Gabriela

    2016-07-14

    Bacillus aquimaris TF12 is a Gram-positive bacteria isolated from a tidal flat of the Yellow Sea in South Korea. We report the draft whole-genome sequence of Bacillus aquimaris TF12, the type strain of a set of bacteria typically associated with marine habitats and with a potentially high biotechnology value.

  8. Draft Whole-Genome Sequence of the Type Strain Bacillus aquimaris TF12T

    PubMed Central

    Hernández-González, Ismael L.

    2016-01-01

    Bacillus aquimaris TF12 is a Gram-positive bacteria isolated from a tidal flat of the Yellow Sea in South Korea. We report the draft whole-genome sequence of Bacillus aquimaris TF12, the type strain of a set of bacteria typically associated with marine habitats and with a potentially high biotechnology value. PMID:27417832

  9. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  10. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  11. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  12. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  13. 29 CFR 417.12 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Proposed findings and conclusions. 417.12 Section 417.12... findings and conclusions. Within 10 days following the close of hearings, interested persons may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting...

  14. TF-4020A: TFL's new compact military rubidium standard

    NASA Astrophysics Data System (ADS)

    Eltsufin, E.; Stern, A.

    1992-06-01

    A military rubidium frequency standard model TF-4020A is described and analyzed. It is a compact (volume less than 500 cc) military rubidium standard and meets MIL-E-5400 (airborne electronic equipment) class 2 (-55 C to +71 C, 70,000 ft). The physics package shown is extremely small (87 cc) and comprises lamp and cavity subassembly and a twofold magnetic field. The oscillator is a miniature oven controlled crystal oscillator with a SC (Stress Compensated) cut crystal for a low vibration susceptibility. The main effort during the design process was concentrated on the design of reliable circuits: general reliability, stability and low susceptibility to external and internal influences like temperature, vibration and electromagnetic interference (EMI). Key features of the unit are: compact design; extremely small physics package (87 cc) with a special rugged design to withstand strong vibration; high stability over the wide operating temperature range of -55 C to +71 C; low susceptibility to EMI; low sensitivity to external DC and AC magnetic field; excellent short term stability of 7 x 10(exp -12)/square root of tau for tau greater than 0.1 s and less than 300 s; excellent long term stability of 1 x 10(exp -11) per month; and versatility to adopt versions without size increase.

  15. Diamagnetic measurements based on the compensation of TF current diffusion in J-TEXT.

    PubMed

    Zhu, L Z; Chen, Z P; Li, F M; Liu, H; Chen, Z Y; Zhuang, G

    2016-11-01

    Due to the existence both of toroidal ripples and toroidal field (TF) current diffusion, the toroidal flux changes with time when the TF current is at the flat-top. A diamagnetic measurement based on the compensation of TF current diffusion has been built in J-TEXT to solve this problem. The measurement system includes a double-loop installed in the vacuum vessel and an array of small printed circuit board (PCB) magnetic probes placed on the mid-plane of one TF coil. A model was proposed to analyze and compensate the effect of TF current diffusion. Experiment results show that the residual flux is about 1 × 10(-4) Wb after the compensation and it can meet the need of diamagnetic measurement in J-TEXT.

  16. Diamagnetic measurements based on the compensation of TF current diffusion in J-TEXT

    NASA Astrophysics Data System (ADS)

    Zhu, L. Z.; Chen, Z. P.; Li, F. M.; Liu, H.; Chen, Z. Y.; Zhuang, G.

    2016-11-01

    Due to the existence both of toroidal ripples and toroidal field (TF) current diffusion, the toroidal flux changes with time when the TF current is at the flat-top. A diamagnetic measurement based on the compensation of TF current diffusion has been built in J-TEXT to solve this problem. The measurement system includes a double-loop installed in the vacuum vessel and an array of small printed circuit board (PCB) magnetic probes placed on the mid-plane of one TF coil. A model was proposed to analyze and compensate the effect of TF current diffusion. Experiment results show that the residual flux is about 1 × 10-4 Wb after the compensation and it can meet the need of diamagnetic measurement in J-TEXT.

  17. Special remote tooling developed and utilized to tighten TFTR TF coil casing bolts

    SciTech Connect

    Burgess, T.W.; Walton, G.R.; Meighan, T.G.; Paul, B.L.

    1993-10-01

    Special tooling has been developed and used to tighten toroidal field (TF) coil casing bolts that have loosened from years of Tokamak Fusion Test Reactor (TFTR) operation. Due to their location, many of the TF casing bolts cannot be directly accessed or viewed; their condition was first discovered during unrelated inspections in 1988. Engineering solutions were, sought until 1992, when a remotely operated wrench concept was successfully demonstrated on a TF coil mockup. The concept was developed into several working tools that have successfully been applied to tighten several thousand TF casing bolts during recent scheduled outages. This effort has improved the integrity and reliability of the TF coil system in preparing for the final experimental phase of the TFTR. This paper discusses the design and application of this tooling.

  18. Utility of Access Soluble Transferrin Receptor (sTfR) and sTfR/log Ferritin Index in Diagnosing Iron Deficiency Anemia.

    PubMed

    Shin, Dong Hoon; Kim, Hyun Soo; Park, Min Jeong; Suh, In Bum; Shin, Kyu Sung

    2015-01-01

    The Access(®) soluble transferrin receptor (sTfR) is considered the world's first automated chemiluminescence immunoassay. In this study, the diagnostic utility of this and other tests for serum iron were evaluated by studying their interrelationships with inflammation. A total of 367 patients with anemia (iron deficiency anemia [IDA], 157; anemia of chronic disease [ACD], 210) and 80 normal controls were subjected to a battery of diagnostic tests, including complete blood cell count, serum iron, total iron-binding capacity (TIBC), C-reactive protein (CRP), ferritin, sTfR, and hepcidin. The accuracy of test parameters was determined by the area under the receiver operating characteristic curve (AUC). Patients falling within the ferritin grey zone (10-100 ng/ml) were evaluated separately, given that such individuals are typically difficult to detect and manage in actual clinical practice. CRP was used to assess the correlation between the aforementioned markers of iron and inflammation. The single most accurate diagnostic test used to differentiate IDA from ACD was serum ferritin (AUC 0.989). However, sTfR assay outperformed other tests in the ferritin grey zone (AUC 0.931), and the sTfR/log ferritin index was the most reliable parameter in both scenarios (AUC 0.994 and 0.962, respectively). Ferritin, TIBC, and hepcidin showed the highest correlation with CRP, whereas sTfR displayed the lowest. The Access sTfR and sTfR/log ferritin index enabled highly accurate diagnosis of IDA in the ferritin grey zone. This is an easy-to-use automated chemiluminescence immunoassay, amenable to routine use in hospitals.

  19. Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells

    PubMed Central

    Liu, Ping; Zhang, Haijun; Wu, Xue; Guo, Liting; Wang, Fei; Xia, Guohua; Chen, Baoan; Yin, HaiXiang; Wang, Yonglu; Li, Xueming

    2016-01-01

    Hypoxia is an inseparable component of the solid tumor as well as the bone marrow microenvironment. In this study, we investigated the effect of the novel polyethylene glycol (PEG)-poly L-lysine (PLL)-poly lactic-co-glycolic acid (PLGA) based nanoparticles (NPs) modified by transferrin (Tf) loaded with daunorubicin (DNR) (DNR-Tf-PEG-PLL-PLGA-NPs, abbreviated as DNR-Tf-NPs) on leukemia cells (K562) under hypoxia. In vitro and in vivo tests to determine the effect of the enhanced chemosensitivity were evaluated using the immunofluorescence, flow cytometry, 3,-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-tetrazoliumbromide assay, Western blot analysis, histopathological examination, and immunohistochemistry analysis. Under hypoxia, K562 cells were hypoxia-responsive with the inhibitory concentration 50% (IC50) of DNR increased, resulting in chemotherapy insensitivity. By targeting the transferrin receptor (TfR) on the surface of K562 cells, DNR-Tf-NPs led to an increased intracellular DNR level, enhancing drug sensitivity of K562 cells to DNR with a decreased IC50, even under hypoxia. We further detected the protein levels of hypoxia-inducible factor-1α (HIF-1α), Bcl-2, Bax, and caspase-3 in K562 cells. The results indicated that DNR-Tf-NPs downregulated HIF-1α and induced apoptosis to overcome hypoxia. In the xenograft model, injection of DNR-Tf-NPs significantly suppressed tumor growth, and the immunosignals of Ki67 in DNR-Tf-NPs group was significantly lower than the other groups. It was therefore concluded that DNR-Tf-NPs could be a promising candidate for enhancing drug sensitivity under hypoxia in tumor treatment. PMID:27574446

  20. Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    NASA Astrophysics Data System (ADS)

    van Dyke, Melissa

    2004-02-01

    Through hardware based design and testing, the EFF-TF investigates fission power and propulsion component, subsystems, and integrated system design and performance. Through demonstration of systems concepts (designed by Sandia and Los Alamos National Laboratories) in relevant environments, previous non-nuclear tests in the EFF-TF have proven to be a highly effective method (from both cost and performance standpoint) to identify and resolve integration issues. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. This paper describes the current efforts for 2003.

  1. Advanced development of the spectrum sciences Model 5005-TF, single-event test fixture

    SciTech Connect

    Ackermann, M.R.; Browning, J.S. ); Hughlock, B.W. ); Lum, G.K. ); Tsacoyeanes, W.C. Lab., Inc., Cambridge, MA ); Weeks, M.D. )

    1990-09-01

    This report summarizes the advanced development of the Spectrum Sciences Model 5005-TF, Single-Event Test Fixture. The Model 5005-TF uses a Californium-252 (Cf-252) fission-fragment source to test integrated circuits and other devices for the effects of single-event phenomena. Particle identification methods commonly used in high-energy physics research and nuclear engineering have been incorporated into the Model 5005-TF for estimating the particle charge, mass, and energy parameters. All single-event phenomena observed in a device under test (DUT) are correlated with an identified fission fragment, and its linear energy transfer (LET) and range in the semiconductor material of the DUT.

  2. Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    SciTech Connect

    Van Dyke, Melissa

    2004-02-04

    Through hardware based design and testing, the EFF-TF investigates fission power and propulsion component, subsystems, and integrated system design and performance. Through demonstration of systems concepts (designed by Sandia and Los Alamos National Laboratories) in relevant environments, previous non-nuclear tests in the EFF-TF have proven to be a highly effective method (from both cost and performance standpoint) to identify and resolve integration issues. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers. This paper describes the current efforts for 2003.

  3. CO2-laser isotope separation of tritium with pentafluoroethane-T (C2TF5)

    NASA Astrophysics Data System (ADS)

    Makide, Y.; Kato, S.; Tominaga, T.; Takeuchi, K.

    1982-08-01

    Isotope separation of tritium by CO2 laser-induced multiphoton dissociation (MPD) of C2TF5 is reported for the first time. The MPD spectrum obtained for C2TF5 comprised a broad peak at about 940 cm-1 where C2HF5 was nearly transparent. The unimolecular dissociation of C2TF5 was induced with much lower laser fluence than that for CTF3, another working molecule we proposed for laser isotope separation of tritium. The mechanisms and kinetics of the dissociation of C2TF5 and C2HF5 were investigated under various experimental conditions: laser frequency, pulse energy, pulse duration, tritium concentration, sample pressure, buffer gas pressure and irradiation geometry. Single-step separation factors exceeding 500 were achieved with the most efficient P(20) line in 00o 10o0 transition at 944.2 cm-1.

  4. 78 FR 39057 - Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Environmental Impact Statement: T.F. Green Airport, Warwick, Rhode Island AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Availability. SUMMARY: The FAA...

  5. Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation.

    PubMed Central

    Schecter, A D; Giesen, P L; Taby, O; Rosenfield, C L; Rossikhina, M; Fyfe, B S; Kohtz, D S; Fallon, J T; Nemerson, Y; Taubman, M B

    1997-01-01

    Tissue factor (TF) is a transmembrane glycoprotein that initiates the coagulation cascade. Because of the potential role of TF in mediating arterial thrombosis, we have examined its expression in human aortic and coronary artery smooth muscle cells (SMC). TF mRNA and protein were induced in SMC by a variety of growth agonists. Exposure to PDGF AA or BB for 30 min provided all of the necessary signals for induction of TF mRNA and protein. This result was consistent with nuclear runoff analyses, demonstrating that PDGF-induced TF transcription occurred within 30 min. A newly developed assay involving binding of digoxigenin-labeled FVIIa (DigVIIa) and digoxigenin-labeled Factor X (DigX) was used to localize cellular TF. By light and confocal microscopy, prominent TF staining was seen in the perinuclear cytoplasm beginning 2 h after agonist treatment and persisting for 10-12 h. Surface TF activity, measured on SMC monolayers under flow conditions, increased transiently, peaking 4-6 h after agonist stimulation and returning to baseline within 16 h. Peak surface TF activity was only approximately 20% of total TF activity measured in cell lysates. Surface TF-blocking experiments demonstrated that the remaining TF was found as encrypted surface TF, and also in an intracellular pool. The relatively short-lived surface expression of TF may be critical for limiting the thrombotic potential of intact SMC exposed to growth factor stimulation. In contrast, the encrypted surface and intracellular pools may provide a rich source of TF under conditions associated with SMC damage, such as during atherosclerotic plaque rupture or balloon arterial injury. PMID:9410905

  6. Large-scale preparation of glycopeptides harboring the TF-antigen unit from royal jelly.

    PubMed

    Maeda, Megumi; Tanaka, Tatsuya; Kimura, Mariko; Kimura, Yoshinobu

    2014-01-01

    We have reported that new N-glycans carrying the TF-antigen occurred on a major royal jelly glycoprotein, and we have identified the glycosylation site to which the antigenic N-glycan is linked, but an appropriate procedure has not been established to prepare non-labeled immunoreactive glycopeptides in large amounts for functional analysis. In this study, we developed an effective method of preparing Asn-glycopeptide bearing TF-antigen.

  7. Hypoxia and PGE(2) regulate MiTF-CX during cervical ripening.

    PubMed

    Hari Kishore, Annavarapu; Li, Xiang-Hong; Word, R Ann

    2012-12-01

    The mechanisms by which the cervix remains closed during the massive uterine expansion of pregnancy are unknown. IL-8 is important for recruitment of immune cells into the cervical stroma, matrix remodeling, and dilation of the cervix during labor. Previously, we have shown that several cytokine genes transcriptionally repressed in the cervix during gestation are activated during cervical ripening and dilation. IL-8 gene expression is repressed in cervical stromal cells during pregnancy by the transcription factor microphthalmia-associated transcription factor (MiTF-CX). Here, we tested the hypothesis that hypoxia and the transcription factor hypoxia inducible factor-1α (HIF-1α) may regulate MiTF-CX and cervical ripening. Using tissues from women during pregnancy before and after cervical ripening, we show that, during cervical ripening, HIF-1α was stabilized and relocalized to the nucleus. Further, we found that hypoxia and two hypoxia mimetics that stabilize HIF-1α activated the transcriptional repressor differentiated embryo chondrocyte-expressed gene 1, which bound to sites in the MiTF-CX promoter crucial for its positive autoregulation. Ectopic overexpression of MiTF-CX abrogated hypoxia-induced up-regulation of IL-8 gene expression. We also show that activation of HIF-1α induced cyclooxygenase-2 and that prostaglandin E(2) repressed MiTF-CX. We conclude that hypoxia and stabilization of the transcription factor HIF-1α result in up-regulation of differentiated embryo chondrocyte-expressed gene 1, loss of MiTF, and absence of MiTF binding to the IL-8 promoter, which in turn leads to up-regulation of IL-8 gene expression. Hypoxia also up-regulated cyclooxygenase-2, leading to prostaglandin E(2)-mediated loss of MiTF in cervical stromal cells. The results support a pivotal role for hypoxia and HIF-1α in the cervical ripening process during pregnancy.

  8. BOREAS TF-11 SSA-Fen 1995 Leaf Area Index Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are LAI measurements made by the TF-11 team throughout the 1995 growing season. The data include the LAI of plants that fall into six categories: total, Carex spp., Betula pumila, Menyanthes trifoliata, Salix spp., and other vascular plants. The data are stored in tabular ASCII files.

  9. Problems in modeling TF ripple loss of fast alphas from a tokamak reactor

    SciTech Connect

    Hively, L.M.

    1987-01-01

    The present status of modeling TF ripple loss of fast alphas from tokamaks is summarized. The modeling issues are discussed, and several new aspects of this problem are described, including gyromotion, radial electric field, and sawtoothing. Existing models predict that TF ripple loss of fast alphas will have a low-to-moderate impact on the design of a tokamak engineering test reactor (ETR). 52 refs., 3 figs., 2 tabs.

  10. Modelization of the thermal coupling between the ITER TF coil conductor and the structure cooling circuit

    NASA Astrophysics Data System (ADS)

    Gauthier, F.; Bessette, D.; Hoa, C.; Rousset, B.; Lacroix, B.

    2016-12-01

    The ITER Toroidal Field (TF) coils are required not to quench during the most demanding event: a plasma disruption followed by a fast discharge of the Central Solenoid (CS), the Poloidal Field (PF) coils and the Correction Coils (CC). This event creates large heat deposition in the ITER magnet stainless steel structures in addition to the conductor AC losses. In order to prevent quench occurring in the TF conductor, cooling channels, implemented in the TF coil structure (TFCS), have to remove a large fraction of the heat deposited. The first integrated TF and structure mock-up has been manufactured and then tested in the HELIOS cryogenic test facility (CEA Grenoble) to determine the thermal coupling between the TFCS and the TF conductor, both actively cooled by supercritical helium at 4.4 K and 5 bar. It consists in a stainless steel casing, a cooling pipe glued with resin in the casing groove, winding pack (WP) ground insulation, a radial plate and a copper dummy cable-in-conduit-conductor (CICC). Steady state as well as transient thermal characterizations have been completed in May 2015. Simulation results by thermal hydraulic codes (VENECIA/SuperMagnet) and some of the experimental data are presented and discussed. The thermal coupling between the helium in the cooling tube and the TF coil structure is then modelled as an equivalent heat transfer coefficient in order to simplify the thermal hydraulic (TH) models. Comparison between simplified coupling and detailed coupling is presented.

  11. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

    PubMed Central

    Mastroberardino, Pier Giorgio; Hoffman, Eric K.; Horowitz, Maxx P.; Betarbet, Ranjita; Taylor, Georgia; Cheng, Dongmei; Na, Hye Mee; Gutekunst, Claire-Anne; Gearing, Marla; Trojanowski, John Q.; Anderson, Marjorie; Chu, Charleen T.; Peng, Junmin; Greenamyre, J. Timothy

    2009-01-01

    More than 80 years after iron accumulation was initially described in the substantia nigra (SN) of Parkinson's disease (PD) patients, the mechanisms responsible for this phenomenon are still unknown. Similarly, how iron is delivered to its major recipients in the cell – mitochondria and the respiratory complexes – has yet to be elucidated. Here, we report a novel transferrin/transferrin receptor 2 (Tf/TfR2)-mediated iron transport pathway in mitochondria of SN dopamine neurons. We found that TfR2 has a previously uncharacterized mitochondrial targeting sequence that is sufficient to import the protein into these organelles. Importantly, the Tf/TfR2 pathway can deliver Tf bound iron to mitochondria and to the respiratory complex I as well. The pathway is redox-sensitive and oxidation of Tf thiols to disulfides induces release from Tf of highly reactive ferrous iron, which contributes to free radical production. In the rotenone model of PD, Tf accumulates in dopamine neurons, with much of it accumulating in the mitochondria. This is associated with iron deposition in SN, similar to what occurs in PD. In the human SN, TfR2 is also found in mitochondria of dopamine neurons, and in PD there is a dramatic increase of oxidized Tf in SN. Thus, we have discovered a novel mitochondrial iron transport system that goes awry in PD, and which may provide a new target for therapeutic intervention. PMID:19250966

  12. COUP-TF II homodimers are formed in preference to heterodimers with RXR alpha or TR beta in intact cells.

    PubMed Central

    Butler, A J; Parker, M G

    1995-01-01

    Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses the transcriptional activity of a number of nuclear receptors, including that of retinoid receptors (RAR and RXR) and thyroid hormone receptors (TR). Since COUP-TF is capable of binding to DNA in vitro either as a homodimer or as a heterodimer with RXR or TR, it has not been possible to distinguish between competitive DNA binding and heterodimer formation as a mechanism to account for the repression. Using a two-hybrid system we have investigated the dimerisation properties of COUP-TF II in intact cells. In conditions where COUP-TF II homodimers and RXR alpha-RAR alpha heterodimers were formed we were unable to detect the formation of heterodimers between COUP-TF II and RXR alpha. Moreover, we were unable to detect an interaction between COUP-TF II and RXR alpha on DNA. Similarly COUP-TF II homodimers and RXR alpha-TR beta heterodimers are favoured over COUP-TF II-TR beta heterodimers. We conclude that the formation of functionally inactive heterodimers is unlikely to represent a general mechanism by which COUP-TF represses the transcriptional activity of nuclear receptors and favour a model in which repression is mediated by COUP-TF homodimers competing for binding to DNA. Images PMID:7479078

  13. Estimation of Theaflavins (TF) and Thearubigins (TR) Ratio in Black Tea Liquor Using Electronic Vision System

    NASA Astrophysics Data System (ADS)

    Akuli, Amitava; Pal, Abhra; Ghosh, Arunangshu; Bhattacharyya, Nabarun; Bandhopadhyya, Rajib; Tamuly, Pradip; Gogoi, Nagen

    2011-09-01

    Quality of black tea is generally assessed using organoleptic tests by professional tea tasters. They determine the quality of black tea based on its appearance (in dry condition and during liquor formation), aroma and taste. Variation in the above parameters is actually contributed by a number of chemical compounds like, Theaflavins (TF), Thearubigins (TR), Caffeine, Linalool, Geraniol etc. Among the above, TF and TR are the most important chemical compounds, which actually contribute to the formation of taste, colour and brightness in tea liquor. Estimation of TF and TR in black tea is generally done using a spectrophotometer instrument. But, the analysis technique undergoes a rigorous and time consuming effort for sample preparation; also the operation of costly spectrophotometer requires expert manpower. To overcome above problems an Electronic Vision System based on digital image processing technique has been developed. The system is faster, low cost, repeatable and can estimate the amount of TF and TR ratio for black tea liquor with accuracy. The data analysis is done using Principal Component Analysis (PCA), Multiple Linear Regression (MLR) and Multiple Discriminate Analysis (MDA). A correlation has been established between colour of tea liquor images and TF, TR ratio. This paper describes the newly developed E-Vision system, experimental methods, data analysis algorithms and finally, the performance of the E-Vision System as compared to the results of traditional spectrophotometer.

  14. SM-TF: A structural database of small molecule-transcription factor complexes.

    PubMed

    Xu, Xianjin; Ma, Zhiwei; Sun, Hongmin; Zou, Xiaoqin

    2016-06-30

    Transcription factors (TFs) are the proteins involved in the transcription process, ensuring the correct expression of specific genes. Numerous diseases arise from the dysfunction of specific TFs. In fact, over 30 TFs have been identified as therapeutic targets of about 9% of the approved drugs. In this study, we created a structural database of small molecule-transcription factor (SM-TF) complexes, available online at http://zoulab.dalton.missouri.edu/SM-TF. The 3D structures of the co-bound small molecule and the corresponding binding sites on TFs are provided in the database, serving as a valuable resource to assist structure-based drug design related to TFs. Currently, the SM-TF database contains 934 entries covering 176 TFs from a variety of species. The database is further classified into several subsets by species and organisms. The entries in the SM-TF database are linked to the UniProt database and other sequence-based TF databases. Furthermore, the druggable TFs from human and the corresponding approved drugs are linked to the DrugBank. © 2016 Wiley Periodicals, Inc.

  15. Characterization of cryobiological responses in TF-1 cells using interrupted freezing procedures.

    PubMed

    Ross-Rodriguez, Lisa U; Elliott, Janet A W; McGann, Locksley E

    2010-04-01

    Cryopreservation currently is the only method for long-term preservation of cellular viability and function for uses in cellular therapies. Characterizing the cryobiological response of a cell type is essential in the approach to designing and optimizing cryopreservation protocols. For cells used in therapies, there is significant interest in designing cryopreservation protocols that do not rely on dimethyl sulfoxide (Me(2)SO) as a cryoprotectant, since this cryoprotectant has been shown to have adverse effects on hematopoietic stem cell (HSC) transplant patients. This study characterized the cryobiological responses of the human erythroleukemic stem cell line TF-1, as a model for HSC. We measured the osmotic parameters of TF-1 cells, including the osmotically-inactive fraction, temperature-dependent membrane hydraulic conductivity and the membrane permeability to 1M Me(2)SO. A two-step freezing procedure (interrupted rapid cooling with hold time) and a graded freezing procedure (interrupted slow cooling without hold time) were used to characterize TF-1 cell recovery during various phases of the cooling process. One outcome of these experiments was high recovery of TF-1 cells cryopreserved in the absence of traditional cryoprotectants. The results of this study of the cryobiology of TF-1 cells will be critical for future understanding of the cryobiology of HSC, and to the design of cryopreservation protocols with specific design criteria for applications in cellular therapies.

  16. Obesity-Linked Homologues TfAP-2 and Twz Establish Meal Frequency in Drosophila melanogaster

    PubMed Central

    Williams, Michael J.; Goergen, Philip; Rajendran, Jayasimman; Zheleznyakova, Galina; Hägglund, Maria G.; Perland, Emelie; Bagchi, Sonchita; Kalogeropoulou, Argyro; Khan, Zaid; Fredriksson, Robert; Schiöth, Helgi B.

    2014-01-01

    In all animals managing the size of individual meals and frequency of feeding is crucial for metabolic homeostasis. In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Loss of TfAP-2 or Twz in octopaminergic neurons increased the size of individual meals, while overexpression of TfAP-2 significantly decreased meal size and increased feeding frequency. Of note, our study reveals that TfAP-2 and Twz regulate octopamine signaling to initiate feeding; then octopamine, in a negative feedback loop, induces expression of Dsk to inhibit consummatory behavior. Intriguingly, we found that the mouse TfAP-2 and Twz homologues, AP-2β and Kctd15, co-localize in areas of the brain known to regulate feeding behavior and reward, and a proximity ligation assay (PLA) demonstrated that AP-2β and Kctd15 interact directly in a mouse hypothalamus-derived cell line. Finally, we show that in this mouse hypothalamic cell line AP-2β and Kctd15 directly interact with Ube2i, a mouse sumoylation enzyme, and that AP-2β may itself be sumoylated. Our study reveals how two obesity-linked homologues regulate metabolic homeostasis by modulating consummatory behavior. PMID:25187989

  17. Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors

    PubMed Central

    2013-01-01

    Inhibitors of the Tissue Factor/Factor VIIa (TF-FVIIa) complex are promising novel anticoagulants that show excellent efficacy and minimal bleeding in preclinical models. On the basis of a zwitterionic phenylglycine acylsulfonamide 1, a phenylglycine benzylamide 2 was shown to possess improved permeability and oral bioavailability. Optimization of the benzylamide, guided by X-ray crystallography, led to a potent TF-FVIIa inhibitor 18i with promising oral bioavailability, but promiscuous activity in an in vitro safety panel of receptors and enzymes. Introducing an acid on the pyrrolidine ring, guided by molecular modeling, resulted in highly potent, selective, and efficacious TF-FVIIa inhibitors with clean in vitro safety profile. The pyrrolidine acid 20 showed a moderate clearance, low volume of distribution, and a short t1/2 in dog PK studies. PMID:24900796

  18. Evaluation of a novel kit (TF-Test) for the diagnosis of intestinal parasitic infections.

    PubMed

    Gomes, Jancarlo Ferreira; Hoshino-Shimizu, Sumie; Dias, Luiz Cândido S; Araujo, Ana Júlia S A; Castilho, Vera L P; Neves, Fátima A M A

    2004-01-01

    Intestinal parasitic infections are currently a source of concern for Public Health agencies in developing and developed countries. Since three ovum-and-parasite stool examinations have been demonstrated to provide sensitive results, we designed a practical and economical kit (TF-Test) that is now commercially available (Immunoassay Com. Ind. Ltda., São Paulo, Brazil). This kit allows the separate collection of three fecal specimens into a preservative solution. The specimens are then pooled, double-filtered, and concentrated by a single rapid centrifugation process. The TF-Test was evaluated in four different laboratories in a study using 1,102 outpatients and individuals living in an endemic area for enteroparasitosis. The overall sensitivity found using the TF-Test (86.2-97.8%) was significantly higher (P<0.01) than the sensitivity of conventional techniques such as the Coprotest (NL Comércio Exterior Ltda, São Paulo, Brazil) and the combination of Lutz/Hoffman, Faust, and Rugai techniques (De Carli, Diagnóstico Laboratorial das Parasitoses Humanas. Métodos e Técnicas, 1994), which ranged from 48.3% to 75.9%. When the above combined three specimen technique was repeated with three specimens collected on different days, its sensitivity became similar (P>0.01) to that of the TF-Test. The kappa index values of agreement for the TF-Test were consistent (P<0.01), being higher and ranking in a better position than conventional techniques. The high sensitivity, cost/benefit ratio, and practical aspects demonstrate that the TF-Test is suitable for individual diagnosis, epidemiological inquiries, or evaluation of chemotherapy in treated communities.

  19. Experimental characterization of the ITER TF structure cooling in HELIOS test facility

    NASA Astrophysics Data System (ADS)

    Hoa, C.; Rousset, B.; Lacroix, B.; Nicollet, S.; Vallcorba, R.; Bessette, D.; Vostner, A.; Gauthier, F.

    2015-12-01

    During ITER plasma operation, large thermal loads are generated in the stainless steel Toroidal Field (TF) coil casing. To minimize the impact on the temperature of the TF Cable in Conduit Conductor (CICC), these heat loads are intercepted by case cooling channels which are implemented at the interface to the winding pack. One of the design options for the case cooling channels consists of a stainless steel pipe inserted in a rectangular groove which is machined in the casing and filled by a charged resin of high thermal conductivity. A higher number of cooling pipes is arranged at the plasma facing wall of the case, thus providing a better shielding to the TF conductor at high field. To assess the efficiency of the cooling pipes and their thermal coupling with the charged resin, experimental characterizations have been performed. First of all, the thermal resistance vs temperature of some of the individual components of a TF coil has been measured on representative samples in a cryogenic bench. Further characterizations have been performed on an integrated mock-up of the TF cooling scheme at cryogenic temperature in HELIOS test facility at CEA Grenoble. The mock-up consists of a piece of TF casing that can be heated uniformly on its surface, one cooling channel implemented in the groove which is filled with the charged resin, the filler, the ground insulation, the radial plate and one insulated CICC. The cooling pipe and the CICC are cooled by supercritical helium at 4.4 K and 5 bar; the instrumentation consists of temperature, pressure and mass flow sensors. Both stationary and transient operating modes have been investigated to assess the thermal efficiency of the case cooling design. The experimental tests are presented and the first results are discussed and analyzed in this document.

  20. Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.

    PubMed

    Wang, Jianguo; Mahmud, Shawn A; Bitterman, Peter B; Huo, Yuqing; Slungaard, Arne

    2007-09-28

    Histone deacetylase inhibitors (HDACi), such as trichostatin A (TSA), can regulate gene expression by promoting acetylation of histones and transcription factors. Human tissue factor (TF) expression is partly governed by a unique, NF-kappaB-related "TF-kappaB" promoter binding site. We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin. TSA and butyrate also blunt TF induction approximately 50% in vitro in peripheral blood mononuclear cells and in vivo in thioglycolate-elicited murine peritoneal macrophages. In human umbilical vein endothelial cells, TSA attenuates by approximately 70% TNF-alpha stimulation of TF mRNA transcription without affecting that of ICAM-1. By electrophoretic mobility shift assay analyses, TNF-alpha and lipopolysaccharide induce strong p65/p50 and p65/c-Rel heterodimer binding to both NF-kappaB and TF-kappaB probes. TSA nearly abolishes TF-kappaB binding without affecting NF-kappaB binding. A chromatin immunoprecipitation assay and a promoter-luciferase reporter system confirm that TSA inhibits TF-kappaB but not NF-kappaB activation. Chromatin immunoprecipitation and small interfering RNA inhibitor studies demonstrate that HDAC3 plays a significant role in TNF-alpha-mediated TF induction. Thus, HDACi transcriptionally inhibit agonist-induced TF expression in endothelial cells and monocytes by a TF-kappaB- and HDAC3-dependent mechanism. We conclude that histone deacetylases, particularly HDAC3, play a hitherto unsuspected role in regulating TF expression and raise the possibility that HDACi might be a novel therapy for thrombotic disorders.

  1. Improvements and applications of COBRA-TF for stand-alone and coupled LWR safety analyses

    SciTech Connect

    Avramova, M.; Cuervo, D.

    2006-07-01

    The advanced thermal-hydraulic subchannel code COBRA-TF has been recently improved and applied for stand-alone and coupled LWR core calculations at the Pennsylvania State Univ. in cooperation with AREVA NP GmbH (Germany)) and the Technical Univ. of Madrid. To enable COBRA-TF for academic and industrial applications including safety margins evaluations and LWR core design analyses, the code programming, numerics, and basic models were revised and substantially improved. The code has undergone through an extensive validation, verification, and qualification program. (authors)

  2. Prevalence of Anaemia and Evaluation of Transferrin Receptor (sTfR) in the Diagnosis of Iron Deficiency in the Hospitalized Elderly Patients: Anaemia Clinical Studies in Chile.

    PubMed

    López-Sierra, Mauricio; Calderón, Susana; Gómez, Jorge; Pilleux, Lilian

    2012-01-01

    Iron constitutes the most prevalent nutritional deficiency worldwide. In Chile, anaemia epidemiological data is scarce, evaluating mainly children and women. Our objective was to determine prevalence of anaemia in an inpatient elderly population (≥60 years) and assess the usefulness of sTfR levels analyzed by other authors as a good predictor in the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease. Method. We studied medical patients admitted at Hospital of Valdivia (HV), Chile, in a 2month period. World Health Organization criteria were used for anaemia. Results. 391 patients were hospitalized, average age 62.5 years, 247 elderly and 99 of which had anaemia. Anaemia was normocytic in 88.8%, and we observed: low serum iron in 46.3%, low ferritin 10.1%, high TIBC 2%, low % transferrin saturation (Tsat) 40%, and high sTfR 25%. Conclusions. As a first figure known in Chile, the prevalence of anaemia in the elderly inpatient was 40.1%. Our findings encourage us to promote the implementation of sTfR determination in the clinical setting to analyze the state of erythropoiesis in patients with chronic diseases wich commonly occurs in elderly.

  3. Identification, modification, and implementation of an evidence-based psychotherapy for children in a low-income country: the use of TF-CBT in Zambia

    PubMed Central

    2013-01-01

    Background The need to address the treatment gap in mental health services in low- and middle-income countries (LMIC) is well recognized and particularly neglected among children and adolescents. Recent literature with adult populations suggests that evidence-based mental health treatments are effective, feasible, and cross-culturally modifiable for use in LMIC. This paper addresses a gap in the literature documenting pre-trial processes. We describe the process of selecting an intervention to meet the needs of a particular population and the process of cross-cultural adaptation. Methods Community-based participatory research principles were implemented for intervention selection, including joint meetings with stakeholders, review of qualitative research, and review of the literature. Trauma-focused Cognitive Behavioral Therapy (TF-CBT) was chosen as the evidence-based practice for modification and feasibility testing. The TF-CBT adaptation process, rooted within an apprenticeship model of training and supervision, is presented. Clinical case notes were reviewed to document modifications. Results Choosing an intervention can work as a collaborative process with community involvement. Results also show that modifications were focused primarily on implementation techniques rather than changes in TF-CBT core elements. Conclusions Studies documenting implementation processes are critical to understanding why intervention choices are made and how the adaptations are generated in global mental health. More articles are needed on how to implement evidence-based treatments in LMIC. PMID:24148551

  4. Evaluation of in vivo quantification accuracy of the Ingenuity-TF PET/MR

    SciTech Connect

    Maus, Jens Schramm, Georg; Hofheinz, Frank; Lougovski, Alexandr; Petr, Jan; Steinbach, Jörg; Oehme, Liane; Beuthien-Baumann, Bettina; Kotzerke, Jörg; Platzek, Ivan; Hoff, Jörg van den

    2015-10-15

    true” events showed no relevant deviation over time, the linearity scans revealed a systematic error of 8%–11% (avg. 9%) for the range of singles rates present in the bladder scans. After correcting for this systematic bias caused by shortcomings of the manufacturers calibration procedure, the PET to well-counter ratio increased to 0.832 ± 0.064 (0.668 –0.941), P = 1.1 ⋅ 10{sup −10}. After compensating for truncation of the upper extremities in the MR-based attenuation maps, the ratio further improved to 0.871 ± 0.069 (0.693–0.992), P = 3.9 ⋅ 10{sup −8}. Conclusions: Our results show that the Philips PET/MR underestimates activity concentrations in the bladder by 17%, which is 7 percentage points (pp.) larger than in the previously investigated PET and PET/CT systems. We attribute this increased underestimation to remaining limitations of the MR-based attenuation correction. Our results suggest that only a 2 pp. larger underestimation of activity concentrations compared to PET/CT can be observed if compensation of attenuation truncation of the upper extremities is applied. Thus, quantification accuracy of the Philips Ingenuity-TF PET/MR can be considered acceptable for clinical purposes given the ±10% error margin in the EANM guidelines. The comparison of PET images from the bladder region with urine samples has proven a useful method. It might be interesting for evaluation and comparison of the in vivo quantitative accuracy of PET, PET/CT, and especially PET/MR systems from different manufacturers or in multicenter trials.

  5. BOREAS TF-5 SSA-OJP Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Baldocchi, Dennis; Vogel, Christoph; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-5) team collected tower flux data at the BOREAS Southern Study Area Old Jack Pine (SSA-OJP) site through the growing season of 1994. The data are available in tabular ASCII files.

  6. BOREAS TF-6 SSA-YA Surface Energy Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Bessemoulin, Pierre; Puech, Dominique; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-6 team collected surface energy flux and meteorology data at the SSA-YA site. The data characterize the energy flux and meteorological conditions at the site from 18-Jul to 20-Sep-1994. The data set does not contain any trace gas exchange measurements. The data are available in tabular ASCII files.

  7. Thermal analysis of the cryostat feed through for the ITER Tokamak TF feeder

    NASA Astrophysics Data System (ADS)

    Shanwen, ZHANG; Yuntao, SONG; Kun, LU; Zhongwei, WANG; Jianfeng, ZHANG; Yongfa, QIN

    2017-04-01

    In Tokamaks, the toroidal field (TF) coil feeder is an important component that is used to supply the cryogens and electrical power for the TF coils. As a part of the TF feeder, the cryostat-feed through (CFT) is subject to low temperatures of 9 and 80 K inside and room temperature of 300 K outside. Based on the features of the International Thermonuclear Experimental Reactor TF feeder, the thermal performance of the CFT under the nominal conditions is studied. Taking into account the conductive, convective and radiation heat transfer, the finite element model of the CFT is built. Transient thermal analysis is performed to determine the temperatures of the CFT on the 9th day of cooldown. The model is assessed by comparing the cooling curves of the CFT after 9 days. If the simulation and experimental results are the same, the finite element model can be considered as calibrated. The model predicts that the cooling time will be approximately 26 days and the temperature distribution and heat load of the main components are obtained when the CFT reaches thermal equilibrium. This study provides a valid quantitative characterization of the CFT design.

  8. BOREAS TF-9 SSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Massheder, Jonathan M.; Moncrieff, John B.; Rayment, Mark B.; Jarvis, Paul G.

    2000-01-01

    The BOREAS TF-9 team collected energy, carbon dioxide, and water vapor flux data at the BOREAS SSA-OBS site during the growing season of 1994 and most of the year for 1996. From the winter of 1995 to 1996, soil temperature data were also collected and provided. The data are available in tabular ASCII files.

  9. BOREAS TF-4 SSA-YJP Tower Flux, Meteorological, and Canopy Condition Data

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team collected energy, carbon dioxide, and water vapor flux data at the BOREAS Southern Study Area-Young Jack Pine (SSA-YJP) site during the growing season of 1994. In addition, meteorological data were collected both above and within the canopy. The data are available in tabular ASCII files.

  10. BOREAS TF-7 SSA-OBS Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Pattey, Elizabeth; Desjardins, Raymond L.

    2000-01-01

    The BOREAS TF-7 team collected meteorological data as well as energy, carbon dioxide, water vapor, methane, and nitrous oxide flux data at the BOREAS SSA-OBS site. The data were collected from 24-May to 19-Sep-1994. The data are available in tabular ASCII files.

  11. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    SciTech Connect

    Robert D. Woolley

    2009-06-11

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress.

  12. A Novel Demountable TF Joint Design for Low Aspect Ratio Spherical Torus Tokamaks

    SciTech Connect

    R.D. Woolley

    2009-05-29

    A novel shaped design for the radial conductors and demountable electrical joints connecting inner and outer legs of copper TF system conductors in low aspect ratio tokamaks is described and analysis results are presented. Specially shaped designs can optimize profiles of electrical current density, magnetic force, heating, and mechanical stress.

  13. Operational experience with the supercritical helium during the TF coils tests campaign of SST-1

    NASA Astrophysics Data System (ADS)

    Panchal, Rohitkumar Natvarlal; Patel, Rakesh; Tank, Jignesh; Mahesuria, Gaurang; Sonara, Dashrath; Tanna, Vipul; Patel, Jayant; Srikanth, G. L. N.; Singh, Manoj; Patel, Ketan; Christian, Dikens; Garg, Atul; Bairagi, Nitn; Gupta, Manoj Kumar; Nimavat, Hiren; Shah, Pankil; Sharma, Rajiv; Pradhan, Subrata

    2012-06-01

    Under the 'SST-1 mission mandate' recently, all the sixteen Steady State Superconducting Tokamak (SST-1) Toroidal Field (TF) magnets have been successfully tested at their nominal currents of 10000 A in cold under supercritical helium (SHe) flow conditions. The TF magnets test campaign have begun in an experimental cryostat since June 2010 with the SST-1 Helium cryogenics facility, which is a 1.3 kW at 4.5 K helium refrigerator-cum-liquefier (HRL) system. The HRL provides ~300 g-s-1supercritical helium (SHe) with cold circulator (CC) as well as ~ 60 g-s-1 without cold circulator to fulfill the forced flow cooling requirements of SST- 1 magnets. In case of single TF coil tests, we can adjust HRL process parameters such that an adequate amount of required supercritical helium is available without the cold circulator. In this paper, the complete process is describing the Process Flow Diagram (PFD) of 1.3 kW at 4.5 K HRL, techniques to generate supercritical helium without using the cold-circulator and the results of the cooldown, steady state characteristics and experience of supercritical helium operations during the TF coils test campaign have been discussed.

  14. BOREAS TF-8 NSA-OJP Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Moore, Kathleen E.; Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team collected energy, CO2, and water vapor flux data at the BOREAS NSA-OJP site during the growing season of 1994 and most of the year for 1996. The data are available in tabular ASCII files.

  15. BOREAS TF-1 SSA-OA Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data above the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-April to the end of the year for 1996. The data are available in tabular ASCII files.

  16. BOREAS TF-1 SSA-OA Understory Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data under the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-October to mid-November of 1993 and throughout all of 1994. The data are available in tabular ASCII files.

  17. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  18. Determination of FVIIa-sTF Inhibitors in Toxic Microcystis Cyanobacteria by LC-MS Technique.

    PubMed

    Anas, Andrea Roxanne J; Nakajima, Anna; Naruse, Chiaki; Tone, Mineka; Asukabe, Hirohiko; Harada, Ken-ichi

    2015-12-30

    The blood coagulation cascade involves the human coagulation factors thrombin and an activated factor VII (fVIIa). Thrombin and fVIIa are vitamin-K-dependent clotting factors associated with bleeding, bleeding complications and disorders. Thrombin and fVIIa cause excessive bleeding when treated with vitamin-K antagonists. In this research, we explored different strains of toxic Microcystis aeruginosa and cyanobacteria blooms for the probable fVIIa-soluble Tissue Factor (fVIIa-sTF) inhibitors. The algal cells were subjected to acidification, and reverse phase (ODS) chromatography-solid phase extraction eluted by water to 100% MeOH with 20%-MeOH increments except for M. aeruginosa NIES-89, from the National Institute for Environmental Studies (NIES), which was eluted with 5%-MeOH increments as an isolation procedure to separate aeruginosins 89A and B from co-eluting microcystins. The 40%-80% MeOH fractions of the cyanobacterial extract are active against fVIIa-sTF. The fVIIa-sTF active fractions from cultured cyanobacteria and cyanobacteria blooms were subjected to liquid chromatography-mass spectrometry (LC-MS). The 60% MeOH fraction of M. aeruginosa K139 exhibited an m/z 603 [M + H]⁺ attributed to aeruginosin K139, and the 40% MeOH fraction of M. aeruginosa NIES-89 displayed ions with m/z 617 [M - SO3 + H]⁺ and m/z [M + H]⁺ 717, which attributed to aeruginosin 89. Aeruginosins 102A/B and 298A/B were also observed from other toxic strains of M. aeruginosa with positive fVIIa-sTF inhibitory activity. The active fractions contained cyanobacterial peptides of the aeruginosin class as fVIIa-sTF inhibitors detected by LC-MS.

  19. 77 FR 73114 - Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green Airport, Warwick, RI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Draft Written Re-Evaluation for Environmental Impact Statement: T.F. Green... to T.F. Green Draft Written Re-Evaluation'' in the subject line Mail: Richard Doucette,...

  20. Epigallocatechin-3-gallate inhibits TF and TNF-α expression induced by the anti-β2GPI/β2GPI complex in human THP-1 cells.

    PubMed

    Wang, Ting; Zhou, Hong; Xie, Hongxiang; Mu, Yuan; Xu, Ya; Liu, Jingjing; Zhang, Xiaolei

    2014-04-01

    Epigallocatechin-3-gallate (EGCG) is the major polyphenolic component of green tea. The aim of the current study was to investigate the inhibitory effects of EGCG on anti-β2-glycoprotein I (β2GPI)/β2GPI-induced tissue factor (TF) and tumor necrosis factor-α (TNF-α) expression in the human acute monocytic leukemia cell line, THP-1, as well as the underlying mechanisms. Human THP-1 cells cultured in vitro were treated with lipopolysaccharide (LPS, 500 ng/ml) or with the anti-β2GPI (10 µg/ml)/β2GPI (100 µg/ml) complex following pre-treatment with or without EGCG (0-50 µg/ml). The expression levels of TF, TNF-α and Toll-like receptor 4 (TLR4) were measured, and the activation of mitogen-activated protein kinases (MAPKs) including p38, extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK), and the nuclear factor-κB (NF-κB) signaling pathway was determined by western blot analysis. The results revealed that the anti-β2GPI/β2GPI complex activated the THP-1 cells, resulting in the enhanced expression of the coagulation cytokine, TF, as well as that of the pro-inflammatory cytokine, TNF-α; these levels were almost comparable to those induced by LPS. Pre-treatment with EGCG decreased the TF and TNF-α levels in the THP-1 cells treated with the anti-β2GPI/β2GPI complex in a dose-dependent manner and counteracted the upregulation of TLR4 expression (mRNA and protein) which was induced by the anti-β2GPI/β2GPI complex or LPS. Furthermore, EGCG suppressed the phosphorylation of p38, ERK1/2 and JNK and blocked the activation of the NF-κB signaling pathway induced by the anti-β2GPI/β2GPI complex or LPS. In conclusion, our results indicate that EGCG decreases the anti-β2GPI/β2GPI-induced TF and TNF-α expression in THP-1 cells possibly through the inhibition of the intracellular signal transduction pathway of TLRs-MAPKs-NF-κB axis and may serve as a preventive and therapeutic agent for antiphospholipid syndrome (APS).

  1. Mutation in Torenia fournieri Lind. UFO homolog confers loss of TfLFY interaction and results in a petal to sepal transformation.

    PubMed

    Sasaki, Katsutomo; Yamaguchi, Hiroyasu; Aida, Ryutaro; Shikata, Masahito; Abe, Tomoko; Ohtsubo, Norihiro

    2012-09-01

    We identified a Torenia fournieri Lind. mutant (no. 252) that exhibited a sepaloid phenotype in which the second whorls were changed to sepal-like organs. This mutant had no stamens, and the floral organs consisted of sepals and carpels. Although the expression of a torenia class B MADS-box gene, GLOBOSA (TfGLO), was abolished in the 252 mutant, no mutation of TfGLO was found. Among torenia homologs such as APETALA1 (AP1), LEAFY (LFY), and UNUSUAL FLORAL ORGANS (UFO), which regulate expression of class B genes in Arabidopsis, only accumulation of the TfUFO transcript was diminished in the 252 mutant. Furthermore, a missense mutation was found in the coding region of the mutant TfUFO. Intact TfUFO complemented the mutant phenotype whereas mutated TfUFO did not; in addition, the transgenic phenotype of TfUFO-knockdown torenias coincided with the mutant phenotype. Yeast two-hybrid analysis revealed that the mutated TfUFO lost its ability to interact with TfLFY protein. In situ hybridization analysis indicated that the transcripts of TfUFO and TfLFY were partially accumulated in the same region. These results clearly demonstrate that the defect in TfUFO caused the sepaloid phenotype in the 252 mutant due to the loss of interaction with TfLFY.

  2. Cults and mental health: clinical conclusions.

    PubMed

    Levine, S V

    1981-12-01

    The field of cults and their relation to psychological and psychiatric disorder is reft with rhetoric and opinion. There has been a particular dearth of documentation and substantiated data supporting psychiatric opinion. As a result of considerable research, clinical work, and an extensive literature review, certain conclusions or strongly suggested positions are enunciated. An attempt is made to substantiate each of the ten assertions based on existing data, in the hope that they will clarify the muddy existing data, area, make clinical positions and interventions more soundly based, and inspire debate and heuristic efforts.

  3. BOREAS TF-11 CO2 and CH4 Concentration Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara (Editor); Valentine, David W.

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains temperature, pH, and concentration profiles of methane and carbon dioxide within the surface 50 cm of peat. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitro-gen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  4. BOREAS TF-11 SSA-Fen 1996 Water Surface Film Capping Data

    NASA Technical Reports Server (NTRS)

    Billesbach, David P.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. The data described in this document were made by the TF-11 team at the SSA-Fen site to quantify the effect that the films observed to form on open water surfaces had on the transfer of carbon dioxide and methane from the water to the air. Measurements of fluxes of carbon dioxide and methane were made in 1994 and in 1996 using the chamber flux method. A gas chromatograph and a LI-COR LI-6200 were used to measure concentrations and to calculate the fluxes. The data are stored in tabular ASCII files.

  5. Parametric system studies of candidate TF coil system options for the Tokamak Fusion Core Experiment (TFCX)

    SciTech Connect

    Reiersen, W.T.; Flanagan, C.A.; Miller, J.B.

    1983-01-01

    System studies were performed to determine the sensitivity of hybrid and superconducting toroidal field (TF) coil system options to maximum field at the TF coil and to field enhancement due to resistive insert coils. The studies were performed using Tokamak Fusion Core Experiment (TFCX) design assumptions, guidelines, and criteria and involved iterative execution of the Fusion Engineering Design Center (FEDC) systems code, magnetohydrodynamics (MHD) equilibrium code, and EFFI (a code to evaluate magnetic field strength). The results indicate that for TFCX with no minimum wall loading specified, a design point chosen solely on the basis of cost would likely be in the low-field region of design space where the cost advantage of hybrids is least apparent. However, as the desired neutron wall loading increases, the hybrid option suggests an increasing cost advantage over the all-superconducting option; this cost advantage is countered by increased complexity in design - particularly in assembly and maintenance.

  6. An ETF TF-coil concept employing NbTi alloy, bath cooled with superfluid helium

    NASA Astrophysics Data System (ADS)

    Hsu, Y.-H.; Purcell, J. R.; Alcorn, J. S.; Homeyer, W.

    1981-01-01

    A preliminary study has been performed to assess the feasibility and engineering consideration of employing NbTi alloy conductor, bath cooled with superfluid helium (He II), in an Engineering Test Facility (ETF) toroidal field (TF) coil. This study indicates that saturated superfluid helium (He II) merits serious consideration as an alternative to the use of He I for high field (11-12 tesla) NbTi alloy TF-coils, which require bath temperatures below 4 K. The primary advantages of He II over reduced temperature (2.5-3 K) He I are two: (1) Due to the extremely high thermal conductivity of He II, almost all of the sub-lambda enthalpy is available to absorb local or transient heat loads; and (2) the relatively high surface heat transfer results in substantially improved conductor stability characteristics. The disadvantages of He II relative to reduced temperature He I are increased refrigeration power and pumping requirements, and some additional system complexity.

  7. BOREAS TF-11 CO2 and CH4 Flux Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains fluxes of methane and carbon dioxide at the SSA-Fen site measured using static chambers. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. In addition to siting and treatment variables, it reports air temperature and water table height relative to the average peat surface during each measurement. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  8. Build 3 of an Accelerated Mission Test of a TF41 with Block 76 Hardware.

    DTIC Science & Technology

    1979-12-01

    34 V " " .. l- NOTICE When Government drawings, specifications, or other data are used for any purpose other than in connection with a definitely related ...or sell any patented invention that may in any way be related thereto. This report has been reviewed by the Infomation Office (01) and is releasable to...the entire fleet has been retrofit and the purging process is time-consuming and causes related nontechnical prob- lems. According to the 1975 TF41

  9. Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

    SciTech Connect

    Smith, F.G. III; Lee, S.Y.; Flach, G.P.; Hamm, L.L.

    1992-01-01

    FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

  10. Two-phase interfacial area and flow regime modeling in FLOWTRAN-TF code

    SciTech Connect

    Smith, F.G. III; Lee, S.Y.; Flach, G.P.; Hamm, L.L.

    1992-12-31

    FLOWTRAN-TF is a new two-component, two-phase thermal-hydraulics code to capture the detailed assembly behavior associated with loss-of-coolant accident analyses in multichannel assemblies of the SRS reactors. The local interfacial area of the two-phase mixture is computed by summing the interfacial areas contributed by each of three flow regimes. For smooth flow regime transitions, the code uses an interpolation technique in terms of component void fraction for each basic flow regime.

  11. BOREAS TF-2 SSA-OA Tethersonde Meteorological and Ozone Data

    NASA Technical Reports Server (NTRS)

    Arnold, A. James; Mickle, Robert E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected meteorological and ozone measurements from instruments mounted below a tethered balloon. These data were collected at the Southern Study Area Old Aspen (SSA-OA) site to extend meteorological and ozone measurements made from the flux tower to heights of 300 m. The tethersonde operated during the fall of 1993 and the spring, summer, and fall of 1994. The data are available in tabular ASCII files.

  12. BOREAS TF-11 SSA-Fen Soil Surface CO2 Flux Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are soil surface CO 2 flux data at the SSA-Fen site from 27- May-1994 to 23-Sep-1994 and from 13-May-1995 to 03-Oct-1995. A portable gas exchange system was used to make these measurements. The data are stored in tabular ASCII files.

  13. Qualification of the US made conductors for ITER TF magnet system

    SciTech Connect

    Martovetsky, N; Hatfield, D; Miller, J; Bruzzone, P; Stepanov, B; Seber, B

    2009-10-08

    The US Domestic Agency (USDA) is one of the six suppliers of the TF conductor for ITER. In order to qualify conductors according to ITER requirements we prepared several lengths of the CICC and short samples for testing in the SULTAN facility in CRPP, Switzerland. We also fully characterized the strands that were used in these SULTAN samples. Fabrication experience and test results are presented and discussed.

  14. BOREAS TF-1 SSA-OA Weekly Tower CH4 and N2O Flux

    NASA Technical Reports Server (NTRS)

    Thurtell, George; Edwards, Grant; Simpson, George; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-1 team collected various trace gas and energy flux data in its efforts to characterize the temporal energy and gas exchanges that occurred over the SSA-OA site. This data set contains methane (CH4) and nitrous oxide (N2O) fluxes that were measured at the BOREAS SSA-OA site. These fluxes were measured from 16-Apr to 16-Sep-1994. The data were averaged to weekly values and are available in tabular ASCII files.

  15. BOREAS TF-4 CO2 and CH4 Chamber Flux Data from the SSA

    NASA Technical Reports Server (NTRS)

    Anderson, Dean; Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-4 team measured fluxes of CO2 and CH4 across the soil-air interface in four ages of jack pine forest at the BOREAS SSA during August 1993 to March 1995. Gross and net flux of CO2 and flux of CH4 between soil and air are presented for 24 chamber sites in mature jack pine forest, 20-year-old, 4-year-old, and clear cut areas. The data are stored in tabular ASCII files.

  16. Exploring lateral genetic transfer among microbial genomes using TF-IDF

    PubMed Central

    Cong, Yingnan; Chan, Yao-ban; Ragan, Mark A.

    2016-01-01

    Many microbes can acquire genetic material from their environment and incorporate it into their genome, a process known as lateral genetic transfer (LGT). Computational approaches have been developed to detect genomic regions of lateral origin, but typically lack sensitivity, ability to distinguish donor from recipient, and scalability to very large datasets. To address these issues we have introduced an alignment-free method based on ideas from document analysis, term frequency-inverse document frequency (TF-IDF). Here we examine the performance of TF-IDF on three empirical datasets: 27 genomes of Escherichia coli and Shigella, 110 genomes of enteric bacteria, and 143 genomes across 12 bacterial and three archaeal phyla. We investigate the effect of k-mer size, gap size and delineation of groups on the inference of genomic regions of lateral origin, finding an interplay among these parameters and sequence divergence. Because TF-IDF identifies donor groups and delineates regions of lateral origin within recipient genomes, aggregating these regions by gene enables us to explore, for the first time, the mosaic nature of lateral genes including the multiplicity of biological sources, ancestry of transfer and over-writing by subsequent transfers. We carry out Gene Ontology enrichment tests to investigate which biological processes are potentially affected by LGT. PMID:27452976

  17. Design considerations for the TF center conductor post for the Ignition Spherical Torus (IST)

    SciTech Connect

    Dalton, G.R.; Haines, J.R.

    1986-01-01

    A trade-off study has been carried out to compare the differential costs of using high-strength alloy copper versus oxygen-free, high-conductivity (OFHC) copper for the center legs of the toroidal field (TF) coils of an Ignition Spherical Torus (IST). The electrical heating, temperatures, stresses, cooling requirements, material costs, pump costs, and power to drive the TF coils and pumps are all assessed for both materials for a range of compact tokamak reactors. The alloy copper material is found to result in a more compact reactor and to allow use of current densities of up to 170 MA/mS versus 40 MA/mS for the OFHC copper. The OFHC conductor system with high current density is $24 million less expensive than more conventional copper systems with 30 MA/mS. The alloy copper system costs $32 million less than conventional systems. Therefore, the alloy system offers a net savings of $8 million compared to the 50% cold-worked OFHC copper system. Although the savings are a significant fraction of the center conductor post cost, they are relatively insignificant in terms of the total device cost. It is concluded that the use of alloy copper contributes very little to the economic or technical viability of the compact IST. It is recommended that a similar systematic approach be applied to evaluating coil material and current density trade-offs for other compact copper-TF-coil tokamak designs. 9 refs., 13 figs., 13 tabs.

  18. Advanced development of the Spectrum Sciences Model 5005-TF, single event test fixture

    NASA Astrophysics Data System (ADS)

    Ackermann, M. R.; Browning, J. S.; Hughlock, B. W.; Lum, G. K.; Tsacoyeanes, W. C.; Weeks, M. D.

    A commercial application of particle identification methods commonly used in high-energy physics research has been developed for single-event testing of microelectronics. The Model 5005-TF single event test fixture can be used to substantially reduce the parts qualification testing costs for many space satellite systems. The 5005-TF includes a californium source, photomultiplier tubes, ultra thin film scintillation detectors, mountings, a vacuum chamber and related controls, and electronics for processing time-of-flight (TOF) signals. Tests were conducted to examine how well the TOF parameter identified the fission fragment (atomic number, mass, kinetic energy). For the lighter fragments, the TOF parameter has a maximum error of about 30 atomic mass units, which is inadequate for particle identification. Since light output of thin-film scintillators was known to correlate with average velocity of a fission fragment passing through the scintillator, it was decided to use the light output in conjunction with TOF to improve particle identification. This dual-parameter method was implemented in the 5005-TF and test results show favorable comparison with results from an ion beam facility.

  19. Copurification of casein kinase II with transcription factor ATF/E4TF3.

    PubMed Central

    Wada, T; Takagi, T; Yamaguchi, Y; Kawase, H; Hiramoto, M; Ferdous, A; Takayama, M; Lee, K A; Hurst, H C; Handa, H

    1996-01-01

    We have developed a simple method to purify sequence-specific DNA-binding proteins directly from crude cell extracts by using DNA affinity latex beads. The method enabled us to purify not only DNA-binding proteins, but also their associated proteins. Using beads bearing the ATF/E4TF3 site from the adenovirus E4 gene promoter, a protein kinase activity was copurified with the ATF/E4TF3 family. We found that the kinase interacted with ATF1 in vitro efficiently. The kinase did not bind directly to DNA. The kinase mainly phosphorylated ATF1 on serine 36, which was one of target amino acids for casein kinase (CK) II. Biological features of the kinase were the same as those of CKII and an anti-CKII serum reacted with the kinase, indicating that the kinase was CKII. Moreover, it was clearly shown that one of CKII subunits, the CKII alpha protein bound to glutathione-S-transferase (GST) fusion ATF1 but not GST in vitro. It has been reported that a specific CKII inhibitor, 5,6-dichloro-1-beta-D-ribo-furanosylbenzimidazole (DRB) inhibits transcription by RNA polymerase II [Zandomeni et al., (1986) J. Biol. Chem. 261, 3414-3419]. Taken together, these results suggest that ATF/E4TF3 may recruit the CKII activity to a transcription initiation machinery and stimulate transcription. PMID:8600455

  20. InPouch™ TF-Feline medium is not specific for Tritrichomonas foetus.

    PubMed

    Ceplecha, Václav; Svoboda, Miroslav; Cepička, Ivan; Husník, Roman; Horáčková, Kateřina; Svobodová, Vlasta

    2013-09-23

    Trichomonads are a group of anaerobic flagellates. Two species of intestinal trichomonads have been described in cats - pathogenic Tritrichomonas foetus and probably harmless Pentatrichomonas hominis. InPouch™ TF-Feline medium (Bio-Med Diagnostics, White City, Oregon, USA) is considered the gold standard for diagnosis of T. foetus infection in cats. It is commercially available, relatively cheap and easy-to-use. The medium is intended to be highly specific to T. foetus as morphologically similar Pentatrichomonas hominis and Giardia sp. do not survive here longer than 24h. In this study we successfully cultivated P. hominis in InPouch™ TF-Feline medium for 3 days after inoculation with cat faeces. The identity of the organism was assessed by sequencing of SSU rDNA and ITS region. Possible coinfection with T. foetus was ruled out using Tritrichomonas-specific PCR. Our results suggest possible misdiagnosis of tritrichomonosis in cats using InPouch™ TF-Feline medium. PCR-based verification of culture-positive samples prior the potentially neurotoxic ronidazole treatment is recommended.

  1. Water-tunnel study results of a TF/A-18 and F/A-18 canopy flow visualization

    NASA Technical Reports Server (NTRS)

    Johnson, Steven A.; Fisher, David F.

    1990-01-01

    A water tunnel study examining the influence of canopy shape on canopy and leading edge extension flow patterns was initiated. The F/A-18 single-place canopy model and the TF/A-18 two place canopy model were the study subjects. Plan view and side view photographs showing the flow patterns created by injected colored dye are presented for 0 deg and 5 deg sideslip angles. Photographs taken at angle of attack and sideslip conditions correspond to test departure points found in flight test. Flight experience has shown that the TF/A-18 airplane departs in regions where the F/A-18 airplane is departure-resistant. The study results provide insight into the differences in flow patterns which may influence the resulting aerodynamics of the TF/A-18 and F/A-18 aircraft. It was found that at 0 deg sideslip, the TF/A-18 model has more downward flow on the sides of the canopy than the F/A-18 model. This could be indicative of flow from the leading edge extension (LEX) vortexes impinging on the sides of the wider TF/A-18 canopy. In addition, the TF/A-18 model has larger areas of asymmetric separated and unsteady flow on the LEXs and fuselage, possibly indicating a lateral and directional destabilizing effect at the conditions studied.

  2. CardioTF, a database of deconstructing transcriptional circuits in the heart system

    PubMed Central

    2016-01-01

    Background: Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The purpose of this database is to collate information on cardiovascular transcription factors (TFs), position weight matrices (PWMs), and enhancer sequences discovered using the ChIP-seq method. Methods: The Naïve-Bayes algorithm was used to classify literature and identify all PubMed abstracts on cardiovascular development. The natural language learning tool GNAT was then used to identify corresponding gene names embedded within these abstracts. Local Perl scripts were used to integrate and dump data from public databases into the MariaDB management system (MySQL). In-house R scripts were written to analyze and visualize the results. Results: Known cardiovascular TFs from humans and human homologs from fly, Ciona, zebrafish, frog, chicken, and mouse were identified and deposited in the database. PWMs from Jaspar, hPDI, and UniPROBE databases were deposited in the database and can be retrieved using their corresponding TF names. Gene enhancer regions from various sources of ChIP-seq data were deposited into the database and were able to be visualized by graphical output. Besides biocuration, mouse homologs of the 81 core cardiac TFs were selected using a Naïve-Bayes approach and then by intersecting four independent data sources: RNA profiling, expert annotation, PubMed abstracts and phenotype. Discussion: The CardioTF database can be used as a portal to construct transcriptional network of cardiac development. Availability and Implementation: Database URL: http://www.cardiosignal.org/database/cardiotf.html. PMID:27635320

  3. Engineering, Manufacture and Preliminary Testing of the ITER Toroidal Field (TF) Magnet Helium Cold Circulator

    NASA Astrophysics Data System (ADS)

    Rista, P. E. C.; Shull, J.; Sargent, S.

    2015-12-01

    The ITER cryodistribution system provides the supercritical Helium (SHe) forced flow cooling to the magnet system using cold circulators. The cold circulators are located in each of five separate auxiliary cold boxes planned for use in the facility. Barber-Nichols Inc. has been awarded a contract from ITER-India for engineering, manufacture and testing of the Toroidal Field (TF) Magnet Helium Cold Circulator. The cold circulator will be extensively tested at Barber-Nichols’ facility prior to delivery for qualification testing at the Japan Atomic Energy Agency's (JAEA) test facility at Naka, Japan. The TF Cold Circulator integrates features and technical requirements which Barber-Nichols has utilized when supplying helium cold circulators worldwide over a period of 35 years. Features include a vacuum-jacketed hermetically sealed design with a very low helium leak rate, a heat shield for use with both nitrogen & helium cold sources, a broad operating range with a guaranteed isentropic efficiency over 70%, and impeller design features for high efficiency. The cold circulator will be designed to meet MTBM of 17,500 hours and MTBF of 36,000 hours. Vibration and speed monitoring are integrated into a compact package on the rotating assembly with operation and health monitoring in a multi-drop PROFIBUS communication environment using an electrical cabinet with critical features and full local and network PLC interface and control. For the testing in Japan and eventual installation in Europe, the cold circulator must be certified to the Japanese High Pressure Gas Safety Act (JHPGSA) and CE marked in compliance with the European Pressure Equipment Directive (PED) including Essential Safety Requirements (ESR). The test methodology utilized at Barber-Nichols’ facility and the resulting test data, validating the high efficiency of the TF Cold Circulator across a broad operating range, are important features of this paper.

  4. Unusual redox stability of neptunium in the ionic liquid [Hbet][Tf(2)N].

    PubMed

    Long, Kristy; Goff, George; Runde, Wolfgang

    2014-07-25

    The behavior of neptunium in the ionic liquid betaine bistriflimide, [Hbet][Tf2N], has been studied spectroscopically at room temperature and 60 °C for the first time. An unprecedented complex redox chemistry is observed, with up to three oxidation states (iv, v and vi) and up to six Np species existing simultaneously. Both redox reactions and coordination of betaine are observed for Np(iv), (v) and (vi). Elevating the temperature accelerates the coordination of Np(v) with betaine and reduction reactions slow down.

  5. A parallelization approach to the COBRA-TF thermal-hydraulic subchannel code

    NASA Astrophysics Data System (ADS)

    Ramos, Enrique; Abarca, Agustín; Roman, Jose E.; Miró, Rafael

    2014-06-01

    In order to reduce the response time when simulating large reactors in detail, we have developed a parallel version of the thermal-hydraulic subchannel code COBRA-TF, with standard message passing technology (MPI). The parallelization is oriented to reactor cells, so it is best suited for models consisting of many cells. The generation of the Jacobian is parallelized, in such a way that each processor is in charge of generating the data associated to a subset of cells. Also, the solution of the linear system of equations is done in parallel, using the PETSc toolkit.

  6. tf_unet: Generic convolutional neural network U-Net implementation in Tensorflow

    NASA Astrophysics Data System (ADS)

    Akeret, Joel; Chang, Chihway; Lucchi, Aurelien; Refregier, Alexandre

    2016-11-01

    tf_unet mitigates radio frequency interference (RFI) signals in radio data using a special type of Convolutional Neural Network, the U-Net, that enables the classification of clean signal and RFI signatures in 2D time-ordered data acquired from a radio telescope. The code is not tied to a specific segmentation and can be used, for example, to detect radio frequency interference (RFI) in radio astronomy or galaxies and stars in widefield imaging data. This U-Net implementation can outperform classical RFI mitigation algorithms.

  7. Survey and update of F-14a mission profiles for TF30 engine usage. Final report

    SciTech Connect

    Cote, S.M.

    1982-04-30

    The mission profiles and maintenance procedures relating to the TF30-P-412 engines have been investigated to find out whether an observed reduction in engine usage was due to different aircraft missions or new flight procedures. A survey of fleet squadron personnel revealed mission profiles are essentially the same; however, fewer air combat engagements and landing practices account for the lower usage. The F-14 role is now more evenly distributed between air combat and intercepts, while the total number of these missions remains constant. A future advanced technology engine in this aircraft is likely to encounter higher usage requirements if there are no throttle cycle restrictions.

  8. Development of dynamic simulation of TF34-GE-100 turbofan engine with post-stall capability

    NASA Technical Reports Server (NTRS)

    Krosel, S. M.

    1984-01-01

    This paper describes the development of a hybrid computer simulation of a TF34-GE-100 turbofan engine with post-stall capability. The simulation operates in real-time and will be used to test and evaluate stall recovery control modes for this engine. The simulation calculations are performed by an analog computer with a peripheral multivariable function generation unit used for computing bivariate functions. Tabular listings of simulation variables are obtained by interfacing to a digital computer and using a custom software package for data collection and display.

  9. Development of dynamic simulation of TF34-GE-100 turbofan engine with post-stall capability

    NASA Technical Reports Server (NTRS)

    Krosel, S. M.

    1984-01-01

    This paper describes the development of a hybrid computer simulation of a TF34-GE-100 turbofan engine with post-stall capability. The simulation operates in real-time and will be used to test and evaluate stall recovery control modes for this engine. The simulation calculations are performed by an analog computer with a peripheral multivariable function generation unit used for computing bivariate functions. Tabular listings of a simulation variables are obtained by interfacing to a digital computer and using a custom software package for data collection and display.

  10. Analysis of distortion data from TF30-P-3 mixed compression inlet test

    NASA Technical Reports Server (NTRS)

    King, R. W.; Schuerman, J. A.; Muller, R. G.

    1976-01-01

    A program was conducted to reduce and analyze inlet and engine data obtained during testing of a TF30-P-3 engine operating behind a mixed compression inlet. Previously developed distortion analysis techniques were applied to the data to assist in the development of a new distortion methodology. Instantaneous distortion techniques were refined as part of the distortion methodology development. A technique for estimating maximum levels of instantaneous distortion from steady state and average turbulence data was also developed as part of the program.

  11. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    NASA Technical Reports Server (NTRS)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  12. Design and performance evaluation of a whole-body Ingenuity TF PET–MRI system

    PubMed Central

    Zaidi, H; Ojha, N; Morich, M; Griesmer, J; Hu, Z; Maniawski, P; Ratib, O; Izquierdo-Garcia, D; Fayad, Z A; Shao, L

    2014-01-01

    The Ingenuity TF PET–MRI is a newly released whole-body hybrid PET–MR imaging system with a Philips time-of-flight GEMINI TF PET and Achieva 3T X-series MRI system. Compared to PET–CT, modifications to the positron emission tomography (PET) gantry were made to avoid mutual system interference and deliver uncompromising performance which is equivalent to the standalone systems. The PET gantry was redesigned to introduce magnetic shielding for the photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of the MR system necessitated the removal of PET gantry electronics to be housed in the PET–MR equipment room. We report the standard NEMA measurements for the PET scanner. PET imaging and performance measurements were done at Geneva University Hospital as described in the NEMA Standards NU2-2007 manual. The scatter fraction (SF) and noise equivalent count rate (NECR) measurements with the NEMA cylinder (20 cm diameter) were repeated for two larger cylinders (27 cm and 35 cm diameter), which better represent average and heavy patients. A NEMA/IEC torso phantom was used for overall assessment of image quality. The transverse and axial resolution near the center was 4.7 mm. Timing and energy resolution of the PET–MR system were measured to be 525 ps and 12%, respectively. The results were comparable to PET–CT systems demonstrating that the effect of design modifications required on the PET system to remove the harmful effect of the magnetic field on the PMTs was negligible. The absolute sensitivity of this scanner was 7.0 cps kBq−1, whereas SF was 26%. NECR measurements performed with cylinders having three different diameters, and image quality measurements performed with IEC phantom yielded excellent results. The Ingenuity TF PET–MRI represents the first commercial whole-body hybrid PET–MRI system. The performance of the PET subsystem was comparable to the GEMINI TF PET–CT system using phantom and patient studies. It is conceived

  13. Modeling and analysis of the TF30-P-3 compressor system with inlet pressure distortion

    NASA Technical Reports Server (NTRS)

    Mazzawy, R. S.; Banks, G. A.

    1976-01-01

    Circumferential inlet distortion testing of a TF30-P-3 afterburning turbofan engine was conducted at NASA-Lewis Research Center. Pratt and Whitney Aircraft analyzed the data using its multiple segment parallel compressor model and classical compressor theory. Distortion attenuation analysis resulted in a detailed flow field calculation with good agreement between multiple segment model predictions and the test data. Sensitivity of the engine stall line to circumferential inlet distortion was calculated on the basis of parallel compressor theory to be more severe than indicated by the data. However, the calculated stall site location was in agreement with high response instrumentation measurements.

  14. Circumferential distortion modeling of the TF30-P-3 compression system

    NASA Technical Reports Server (NTRS)

    Mazzawy, R. S.; Banks, G. A.

    1977-01-01

    Circumferential inlet pressure and temperature distortion testing of the TF30 P-3 turbofan engine was conducted. The compressor system at the test conditions run was modelled according to a multiple segment parallel compressor model. Aspects of engine operation and distortion configuration modelled include the effects of compressor bleeds, relative pressure-temperature distortion alignment and circumferential distortion extent. Model predictions for limiting distortion amplitudes and flow distributions within the compression system were compared with test results in order to evaluate predicted trends. Relatively good agreement was obtained. The model also identified the low pressure compressor as the stall-initiating component, which was in agreement with the data.

  15. BOREAS TF-2 SSA-OA Tower Flux, Meteorological, and Precipitation Data

    NASA Technical Reports Server (NTRS)

    Neumann, Harold; Mickle, Robert; Staebler, Ralf; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected energy, carbon dioxide, water vapor, and momentum flux data above the canopy and in profiles through the canopy, along with meteorological data at the BOREAS Southern Study Area-Old Aspen (SSA-OA) site. Above-canopy measurements began in early February and ran through mid-September of 1994. Measurements were collected over a longer period of 1994 than most BOREAS flux sites. Daily precipitation data from several gauges were also collected. The data are available in tabular ASCII files.

  16. Comparison of tetrel bonds in neutral and protonated complexes of pyridineTF3 and furanTF3 (T = C, Si, and Ge) with NH3.

    PubMed

    Liu, Mingxiu; Li, Qingzhong; Scheiner, Steve

    2017-02-15

    Ab initio calculations have been performed for the complexes H(+)-PyTX3NH3 and H(+)-furanTF3NH3 (T = C, Si, and Ge; X = F and Cl) with focus on geometries, energies, orbital interactions, and electron densities to study the influence of protonation on the strength of tetrel bonding. The primary interaction mode between α/β-furanCF3/p-PyCF3 and NH3 changes from an FH hydrogen bond to a CN tetrel bond as a result of protonation. Importantly, the protonation has a prominent enhancing effect on the strength of tetrel bonding with an increase in binding energy from 14 to 30 kcal mol(-1). The tetrel bonding becomes stronger in the order H(+)-p-PySiF3NH3 < H(+)-m-PySiF3NH3 < H(+)-o-PySiF3NH3, showing a reverse trend from that of the neutral analogues. In addition, there is competition between the tetrel and hydrogen bonds in the protonated complexes, in which the hydrogen bond is favored in the complexes of H(+)-p-PyCF3 but the tetrel bond is preferred in the complexes of H(+)-p-PyTX3 (T = Si, Ge; X = F, Cl) and H(+)-o/m-PySiF3.

  17. CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes

    PubMed Central

    Hestand, Matthew S; van Galen, Michiel; Villerius, Michel P; van Ommen, Gert-Jan B; den Dunnen, Johan T; 't Hoen, Peter AC

    2008-01-01

    Background The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false positives and false negatives in current approaches. Computational methods to reduce false positives are to look for over-representation of transcription factor binding sites in a set of similarly regulated promoters or to look for conservation in orthologous promoter alignments. Results We have developed a novel tool, "CORE_TF" (Conserved and Over-REpresented Transcription Factor binding sites) that identifies common transcription factor binding sites in promoters of co-regulated genes. To improve upon existing binding site predictions, the tool searches for position weight matrices from the TRANSFACR database that are over-represented in an experimental set compared to a random set of promoters and identifies cross-species conservation of the predicted transcription factor binding sites. The algorithm has been evaluated with expression and chromatin-immunoprecipitation on microarray data. We also implement and demonstrate the importance of matching the random set of promoters to the experimental promoters by GC content, which is a unique feature of our tool. Conclusion The program CORE_TF is accessible in a user friendly web interface at . It provides a table of over-represented transcription factor binding sites in the users input genes' promoters and a graphical view of evolutionary conserved transcription factor binding sites. In our test data sets it successfully predicts target transcription factors and their binding sites. PMID:19036135

  18. Cis-Regulatory Control of the Nuclear Receptor Coup-TF Gene in the Sea Urchin Paracentrotus lividus Embryo

    PubMed Central

    Kalampoki, Lamprini G.; Flytzanis, Constantin N.

    2014-01-01

    Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ genomic clones, containing three exons and upstream sequences of PlCoup-TF, were isolated from a genomic library. The transcription initiation site was determined and 5′ deletions and individual segments of a 1930 bp upstream region were placed ahead of a GFP reporter cassette and injected into fertilized P.lividus eggs. Module a (−532 to −232), was necessary and sufficient to confer ciliary band expression to the reporter. Comparison of P.lividus and Strongylocentrotus purpuratus upstream Coup-TF sequences, revealed considerable conservation, but none within module a. 5′ and internal deletions into module a, defined a smaller region that confers ciliary band specific expression. Putative regulatory cis-acting elements (RE1, RE2 and RE3) within module a, were specifically bound by proteins in sea urchin embryonic nuclear extracts. Site-specific mutagenesis of these elements resulted in loss of reporter activity (RE1) or ectopic expression (RE2, RE3). It is proposed that sea urchin transcription factors, which bind these three regulatory sites, are necessary for spatial and quantitative regulation of the PlCoup-TF gene at pluteus stage sea urchin embryos. These findings lead to the future identification of these factors and to the hierarchical positioning of PlCoup-TF within the embryonic GRN. PMID:25386650

  19. Cis-regulatory control of the nuclear receptor Coup-TF gene in the sea urchin Paracentrotus lividus embryo.

    PubMed

    Kalampoki, Lamprini G; Flytzanis, Constantin N

    2014-01-01

    Coup-TF, an orphan member of the nuclear receptor super family, has a fundamental role in the development of metazoan embryos. The study of the gene's regulatory circuit in the sea urchin embryo will facilitate the placement of this transcription factor in the well-studied embryonic Gene Regulatory Network (GRN). The Paracentrotus lividus Coup-TF gene (PlCoup-TF) is expressed throughout embryonic development preferentially in the oral ectoderm of the gastrula and the ciliary band of the pluteus stage. Two overlapping λ genomic clones, containing three exons and upstream sequences of PlCoup-TF, were isolated from a genomic library. The transcription initiation site was determined and 5' deletions and individual segments of a 1930 bp upstream region were placed ahead of a GFP reporter cassette and injected into fertilized P.lividus eggs. Module a (-532 to -232), was necessary and sufficient to confer ciliary band expression to the reporter. Comparison of P.lividus and Strongylocentrotus purpuratus upstream Coup-TF sequences, revealed considerable conservation, but none within module a. 5' and internal deletions into module a, defined a smaller region that confers ciliary band specific expression. Putative regulatory cis-acting elements (RE1, RE2 and RE3) within module a, were specifically bound by proteins in sea urchin embryonic nuclear extracts. Site-specific mutagenesis of these elements resulted in loss of reporter activity (RE1) or ectopic expression (RE2, RE3). It is proposed that sea urchin transcription factors, which bind these three regulatory sites, are necessary for spatial and quantitative regulation of the PlCoup-TF gene at pluteus stage sea urchin embryos. These findings lead to the future identification of these factors and to the hierarchical positioning of PlCoup-TF within the embryonic GRN.

  20. Voc Degradation in TF-VLS Grown InP Solar Cells

    SciTech Connect

    Sun, Yubo; Sun, Xingshu; Johnston, Steve; Sutter-Fella, Carolin M.; Hettick, Mark; Javey, Ali; Bermel, Peter

    2016-11-21

    Here we consider two hypotheses to explain the open-circuit voltage (VOC) degradation observed in thin-film vapor-liquid-solid (TF-VLS) grown p-type InP photovoltaic cells: bandgap narrowing and local shunting. First, a bandgap (Eg) narrowing effect is hypothesized, based on the surface inhomogeneity of VLS InP captured by the photoluminescence (PL) image. The PL data was used to estimate a spatially-resolved active VOC across surface of the InP sample. Combining this data with the effective Jsc allowed an assessment of the I-V characteristics of individual unit cells. Next, an H-SPICE diode compact model was utilized to reproduce the I-V characteristics of the whole sample. We find a good fit to the I-V performance of TF-VLS grown InP solar cell. Second, a local shunting effect was also considered as an alternative explanation of the VOC degradation effect. Again, PL image data was used, and small local shunt resistance was added in arbitrary elementary unit cells to represent certain dark spots seen in the PL image and dictate the VOC degradation occurred in the sample.

  1. Demountable, High field High-Temperature Superconductor TF coils for flexible steady-state fusion experiments

    NASA Astrophysics Data System (ADS)

    Michael, Phillip; Bromberg, Leslie; Vieira, Rui; Minervini, Joseph; Galea, Christopher; Hensley, Sarah; Whyte, Dennis

    2014-10-01

    The excellent properties of HTS materials (e.g., YBCO) at high fields and elevated temperatures (>20 K), offer operational advantages for fusion machines, but results in challenges. For fusion devices, the ability to disassemble the TF coil is very attractive as it provides direct access to maintain the vacuum vessel, first wall and other components in a timely manner. High current conductors, made from multiple thin tapes, are not available but are being developed. Quench protection is a serious issue with HTS magnets, and novel means are needed to detect normal zones and to quickly discharge the magnet. Potential cables designs, demountable magnets and solutions to quench and protection issues for an HTS TF magnet for the Vulcan device (long term PMI studies) will be described. We also describe means for making continuous, persistent loops with HTS tapes. These loops offer an alternative to expensive monoliths for field control for complex geometries, such as stellarator-like fields. Partially supported by US DOE DE-FC02-93ER54186.

  2. TFTR D&D Project: Final Examination and Testing of the TFTR TF-Coils

    SciTech Connect

    Irving J. Zatz

    2003-01-31

    In operation for nearly 15 years, TFTR (Tokamak Fusion Test Reactor) was not only a fusion science milestone, but a milestone of achievement in engineering as well. The TFTR D&D (Decommissioning and Decontamination) program provided a rare opportunity to examine machine components that had been exposed to a unique performance environment of greater than 100,000 mechanical and thermal load cycles. In particular, the possible examination of the TFTR toroidal-field (TF) coils, which met, then exceeded, the 5.2 Tesla magnetic field machine specification, could supply the answers to many questions that have been asked and debated since the coils were originally designed and built. A test program conducted in parallel with the D&D effort was the chance to look inside and examine, in detail, the TFTR TF coils for the first time since they were delivered encased to PPPL (Princeton Plasma Physics Laboratory). The results from such a program would provide data and insight that would not only be nefit PPPL and the fusion community, but the broader scientific community as well.

  3. Design of a TF34 turbofan mixer for reduction of flap impingement noise

    NASA Technical Reports Server (NTRS)

    Chamay, A.; Edkins, D. P.; Mishler, R. B.; Clapper, W. S.

    1972-01-01

    This portion of the TF-34 turbofan quiet engine studies has been devoted to the selection and design of a special mixer exhaust nozzle system to reduce the maximum 150 m (500 foot) sideline noise generated by the impingement of four engine exhausts on a STOL wing flap system to less than 92 PNdB. The design concept selected consists of a 12-lobe internal mixer and a 12-lobe external mixer mounted in series. The internal mixer reduces maximum exhaust velocities by mixing the fan and turbine streams. The external mixer is designed to reduce the velocity of the exhaust stream striking the wing flap surfaces. A ground test version of this concept has been designed to be installed and tested on an acoustically treated TF-34 engine nacelle, with flexibility to simulate a flight version of this concept which has also been defined. Estimated noise levels are 2 PNdB below the objective at approach and 2 PNdB above the objective at takeoff, with an uncertainty band of +3, -2 PNdB.

  4. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.

    PubMed

    Pereira, F A; Qiu, Y; Tsai, M J; Tsai, S Y

    1995-06-01

    Members of the steroid/thyroid hormone receptor superfamily such as TR, RAR, RXR and VDR are known to play important roles in regulation of gene expression during development, differentiation and homeostasis. COUP-TFs are orphan members of this superfamily of nuclear receptors and have been shown to negatively regulate the ability of these nuclear receptors to transactivate target genes. Two different mechanisms are implicated in this repression. First, COUP-TFs bind to AGGTCA direct repeats and palindromes with various spacings, which include response elements for TR, RAR, RXR and VDR, allowing for direct competition of COUP-TFs for the response elements. Second, COUP-TFs can heterodimerize with RXRs, the essential cofactor for effective binding of VDR, TRs and RARs to their cognate response elements. The physiological significance of this negative effect of COUP-TF on the activity of these receptors has been analyzed. Detection of COUP-TF transcripts during mouse development reveal discrete spatial and temporal expression domains consistent with COUP-TFs being involved in regulation of gene expression during embryogenesis. Transcripts are localized within discrete regions of the central and peripheral nervous system including the inner ear. In addition, COUP-TFs are found in many tissues including testes, ovary, prostate, skin, kidney, lung, stomach, intestine, pancreas and salivary gland. Some of these expression domains colocalize with those of TR, RAR, and RXR. The simultaneous expression of these genes raise the possibility that COUP-TFs can act as negative regulatory factors during development and differentiation.

  5. Qualitative and Quantitative Assays of Transposition and Homologous Recombination of the Retrotransposon Tf1 in Schizosaccharomyces pombe.

    PubMed

    Sangesland, Maya; Atwood-Moore, Angela; Rai, Sudhir K; Levin, Henry L

    2016-01-01

    Transposition and homologous recombination assays are valuable genetic tools to measure the production and integration of cDNA from the long terminal repeat (LTR) retrotransposon Tf1 in the fission yeast (Schizosaccharomyces pombe). Here we describe two genetic assays, one that measures the transposition activity of Tf1 by monitoring the mobility of a drug resistance marked Tf1 element expressed from a multi-copy plasmid and another assay that measures homologous recombination between Tf1 cDNA and the expression plasmid. While the transposition assay measures insertion of full-length Tf1 cDNA mediated by the transposon integrase, the homologous recombination assay measures levels of cDNA present in the nucleus and is independent of integrase activity. Combined, these assays can be used to systematically screen large collections of strains to identify mutations that specifically inhibit the integration step in the retroelement life cycle. Such mutations can be identified because they reduce transposition activity but nevertheless have wild-type frequencies of homologous recombination. Qualitative assays of yeast patches on agar plates detect large defects in integration and recombination, while the quantitative approach provides a precise method of determining integration and recombination frequencies.

  6. Influence of external magnetic fields on the freezing temperature Tf of Ni 79Mn 21 alloys: Evidence for anisotropy rotation

    NASA Astrophysics Data System (ADS)

    Öner, Y.; Firat, T.; Ercan, İ.; Aktaş, B.

    1988-04-01

    DC magnetization measurements have been performed for Ni 79Mn 21 alloys in the temperature range of 4.2 to 50 K. Taking the demagnetizing field into account, the influence of an external magnetic field, Hext, on the re-entrant spin-glass transition temperature Tf of this alloy has been investigated. It has been observed that Tf is independent of Hext if Hext is sma ller than the demagnetizing field HD ( = NMs) where N is the demagnetizing factor; Ms is the value of the saturation magnetization. However, for higher fields, Tf is displaced towards lower temperatures. These results are interpreted in terms of anisotropy rotation based on the "domain-anisotropy" model.

  7. Real-time simulation of the TF30-P-3 turbofan engine using a hybrid computer

    NASA Technical Reports Server (NTRS)

    Szuch, J. R.; Bruton, W. M.

    1974-01-01

    A real-time, hybrid-computer simulation of the TF30-P-3 turbofan engine was developed. The simulation was primarily analog in nature but used the digital portion of the hybrid computer to perform bivariate function generation associated with the performance of the engine's rotating components. FORTRAN listings and analog patching diagrams are provided. The hybrid simulation was controlled by a digital computer programmed to simulate the engine's standard hydromechanical control. Both steady-state and dynamic data obtained from the digitally controlled engine simulation are presented. Hybrid simulation data are compared with data obtained from a digital simulation provided by the engine manufacturer. The comparisons indicate that the real-time hybrid simulation adequately matches the baseline digital simulation.

  8. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    NASA Technical Reports Server (NTRS)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  9. BOREAS TF-4 CO2 and CH4 Soil Profile Data from the SSA

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team measured distributions of carbon dioxide (CO2) and methane (CH4) concentrations for the upper 5 m of soil and unsaturated zone at the mature stand, upper 6 m at the 20-year-old stand, and the upper 1 m at the 8-year-old stand and clear cut area at the BOREAS Southern Study Area (SSA) during August 1993 to March 1995. Particle size and carbon content of the unsaturated deposits, precipitation, soil temperature and moisture, carbon and oxygen isotopes of soil CO2, and soil water chemistry are also presented. The data are stored in tabular ASCII files.

  10. Evaluating the effectiveness of transferrin receptor-1 (TfR1) as a magnetic resonance reporter gene.

    PubMed

    Pereira, Sofia M; Herrmann, Anne; Moss, Diana; Poptani, Harish; Williams, Steve R; Murray, Patricia; Taylor, Arthur

    2016-05-01

    Magnetic resonance (MR) reporter genes have the potential for tracking the biodistribution and fate of cells in vivo, thus allowing the safety, efficacy and mechanisms of action of cell-based therapies to be comprehensively assessed. In this study, we evaluate the effectiveness of the iron importer transferrin receptor-1 (TfR1) as an MR reporter gene in the model cell line CHO-K1. Overexpression of the TfR1 transgene led to a reduction in the levels of endogenous TfR1 mRNA, but to a 60-fold increase in total TfR1 protein levels. Although the mRNA levels of ferritin heavy chain-1 (Fth1) did not change, Fth1 protein levels increased 13-fold. The concentration of intracellular iron increased significantly, even when cells were cultured in medium that was not supplemented with iron and the amount of iron in the extracellular environment was thus at physiological levels. However, we found that, by supplementing the cell culture medium with ferric citrate, a comparable degree of iron uptake and MR contrast could be achieved in control cells that did not express the TfR1 transgene. Sufficient MR contrast to enable the cells to be detected in vivo following their administration into the midbrain of chick embryos was obtained irrespective of the reporter gene. We conclude that TfR1 is not an effective reporter and that, to track the biodistribution of cells with MR imaging in the short term, it is sufficient to simply culture cells in the presence of ferric citrate. Copyright © 2016 The Authors Contrast Media & Molecular Imaging Published by John Wiley & Sons Ltd.

  11. Employee counseling services evaluation system: design, issues and conclusions.

    PubMed

    Masi, D A; Teems, L A

    1983-01-01

    Employee Counseling Services (ECS) programs have emerged as an effective method for dealing with employees whose job performance has deteriorated due to personal problems such as alcoholism or drug abuse. It is estimated that 18% of any work force is effected by such problems at any given time and that these employees cost industry billions of dollars annually in lost productivity, abuse of sick leave, etc. One of the critical concerns of this emerging field is the need for comprehensive evaluation that can demonstrate the cost-effectiveness and cost-benefits of ECS programs. This paper will describe the model Federal ECS developed at the U.S. Department of Health and Human Services as well as the components of the evaluation system designed to determine its effectiveness. The system is the first of its kind and will be a valuable contribution to the field. The paper then raises issues and develops conclusions about designing such an evaluation within the context of a large bureaucracy.

  12. Inhibitory activity of Lactobacillus plantarum TF711 against Clostridium sporogenes when used as adjunct culture in cheese manufacture.

    PubMed

    González, Lorena; Zárate, Victoria

    2015-05-01

    Bacteriocins produced by lactic acid bacteria are of great interest to the food-processing industry as natural preservatives. This work aimed to investigate the efficacy of bacteriocin-producing Lactobacillus plantarum TF711, isolated from artisanal Tenerife cheese, in controlling Clostridium sporogenes during cheese ripening. Cheeses were made from pasteurised milk artificially contaminated with 10(4) spores m/l C. sporogenes. Experimental cheeses were manufactured with Lb. plantarum TF711 added at 1% as adjunct to commercial starter culture. Cheeses made under the same conditions but without Lb. plantarum TF711 served as controls. Evolution of microbiological parameters, pH and NaCl content, as well as bacteriocin production was studied throughout 45 d of ripening. Addition of Lb. plantarum TF711 did not bring about any significant change in starter culture counts, NaCl content and pH, compared with control cheese. In contrast, clostridial spore count in experimental cheeses were significantly lower than in control cheeses from 7 d onwards, reaching a maximum reduction of 2·2 log units on day 21. Inhibition of clostridia found in experimental cheeses was mainly attributed to plantaricin activity, which in fact was recovered from these cheeses.

  13. Unusual solvatochromic absorbance probe behaviour within mixtures of poly(ethylene glycol)-400 + ionic liquid, [bmim][Tf2N

    NASA Astrophysics Data System (ADS)

    Ali, Anwar; Ali, Maroof; Malik, Nisar Ahmad; Uzair, Sahar

    2014-03-01

    The potentially green solvents made up of ionic liquids (ILs) and poly(ethylene glycols) may have wide range of the applications in many chemical and biochemical fields. In the present work, solvatochromic absorbance probe behaviour is used to assess the physicochemical properties of the mixtures composed of PEG-400 + IL, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide, [bmim][Tf2N]. Lowest energy intramolecular charge-transfer absorbance maxima of a betaine dye, i.e., ETN , indicates the dipolarity/polarizability and/or hydrogen-bond donating (HBD) acidity of the [bmim][Tf2N] + PEG-400 mixtures to be even higher than that of neat [bmim][Tf2N], the solution component with higher dipolarity/polarizability and/or HBD acidity. Dipolarity/polarizability (π∗) obtained separately from the electronic absorbance response of probe N,N-diethyl-4-nitroaniline, and the HBD acidity (α) of PEG-400 + [bmim][Tf2N] mixtures are also observed to be anomalously high. A comparative study of the PEG + IL mixtures has also been done with PEG-400 + molecular organic solvents (protic polar [methanol], aprotic polar [N,N-dimethylformamide], and non polar, [benzene]) mixtures, but these mixtures do not show this type of unusual behaviour. A four-parameter simplified combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) equation is shown to satisfactorily predict the solvatochromic parameters within PEG-400 + different solvent mixtures.

  14. Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index.

    PubMed

    Skikne, Barry S; Punnonen, Kari; Caldron, Paul H; Bennett, Michael T; Rehu, Mari; Gasior, Gail H; Chamberlin, Janna S; Sullivan, Linda A; Bray, Kurtis R; Southwick, Paula C

    2011-11-01

    Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the most prevalent forms of anemia and often occur concurrently. Standard tests of iron status used in differential diagnosis are affected by inflammation, hindering clinical interpretation. In contrast, soluble transferrin receptor (sTfR) indicates iron deficiency and is unaffected by inflammation. Objectives of this prospective multicenter clinical trial were to evaluate and compare the diagnostic accuracy of sTfR and the sTfR/log ferritin index (sTfR Index) for differential diagnosis using the automated Access(®) sTfR assay (Beckman Coulter) and sTfR Index. We consecutively enrolled 145 anemic patients with common disorders associated with IDA and ACD. Subjects with IDA or ACD + IDA had significantly higher sTfR and sTfR Index values than subjects with ACD (P < 0.0001). ROC curves produced the following cutoffs for sTfR: 21 nmol/L (or 1.55 mg/L), and the sTfR Index: 14 (using nmol/L) (or 1.03 using mg/L). The sTfR Index was superior to sTfR (AUC 0.87 vs. 0.74, P < 0.0001). Use of all three parameters in combination more than doubled the detection of IDA, from 41% (ferritin alone) to 92% (ferritin, sTfR, sTfR Index). Use of sTfR and the sTfR Index improves detection of IDA, particularly in situations where routine markers provide equivocal results. Findings demonstrate a significant advantage in the simultaneous determination of ferritin, sTfR and sTfR Index. Obtaining a ferritin level alone may delay diagnosis of combined IDA and ACD.

  15. 1H NMR studies of the 5-(hydroxymethyl)-2'-deoxyuridine containing TF1 binding site.

    PubMed Central

    Pasternack, L B; Bramham, J; Mayol, L; Galeone, A; Jia, X; Kearns, D R

    1996-01-01

    The pyrimidine base 5-(hydroxymethyl)-2'-deoxyuridine (HmU) is a common nucleotide in SPO1 phage DNA. Numerous transcriptional proteins bind HmU-containing DNA preferentially implicating a regulatory function of HmU. We have investigated the conformation and dynamics of d-(5'-CHmUCHmUACACGHmUGHmUAGAG-OH-3')2 (HmU-DNA). This oligonucleotide mimics the consensus sequence of Transcription Factor 1 (TF1). The HmU-DNA was compared to the thymine-containing oligonucleotide. NOESY and DQF COSY spectroscopy provided resonance assignments of nonexchangeable and exchangeable protons, intranucleotide, internucleotide and intrastrand proton-proton distances, and dihedral angle constraints. Methylene protons of the hydroxymethyl group are nonequivalent protons and the hydroxymethyl group is not freely rotating. The hydroxymethyl group adopts a specific orientation with the OH group oriented on the 3' side of the plane of the base. Analysis of imino proton resonances and NOEs indicates additional end base pair fraying and a temperature-induced transition to a conformation in which the internal HmU-A base pairs are disrupted or have reduced lifetimes. Orientation of the hydroxymethyl group indicates the presence of internucleotide intrastrand hydrogen bonding between the HmU12C5 hydroxyl group and A13. All sugars in both DNAs show a C2'endo conformation (typical of B-DNA). PMID:8759005

  16. Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism.

    PubMed

    Pearson, B L; Pobbe, R L H; Defensor, E B; Oasay, L; Bolivar, V J; Blanchard, D C; Blanchard, R J

    2011-03-01

    The BTBR T+tf/J inbred mouse strain displays a variety of persistent phenotypic alterations similar to those exhibited in autism spectrum disorders (ASDs). The unique genetic background of the BTBR strain is thought to underlie its lack of reciprocal social interactions, elevated repetitive self-directed grooming, and restricted exploratory behaviors. In order to clarify the existence, range, and mechanisms of abnormal repetitive behaviors within BTBR mice, we performed detailed analyses of the microstructure of self-grooming patterns and noted increased overall grooming, higher percentages of interruptions in grooming bouts and a concomitant decrease in the proportion of incorrect sequence transitions compared to C57BL/6J inbred mice. Analyses of active phase home-cage behavior also revealed an increase in stereotypic bar-biting behavior in the BTBR strain relative to B6 mice. Finally, in a novel object investigation task, the BTBR mice exhibited greater baseline preference for specific unfamiliar objects as well as more patterned sequences of sequential investigations of those items. These results suggest that the repetitive, stereotyped behavior patterns of BTBR mice are relatively pervasive and reflect both motor and cognitive mechanisms. Furthermore, other pre-clinical mouse models of ASDs may benefit from these more detailed analyses of stereotypic behavior.

  17. Noise suppression by an acoustically treated three-ring inlet on a TF-34 engine

    NASA Technical Reports Server (NTRS)

    Minner, G. L.; Goldman, R. G.; Heidelberg, L. J.

    1976-01-01

    Acoustic performance tests were conducted with a three-ring inlet noise suppressor designed for a TF-34 engine. For all tests the aft noise sources were highly suppressed. The measured inlet suppression was large, reaching levels greater than 30 db at the peak. Comparisons of the data and the performance predictions were in reasonably good agreement. The frequency of peak attenuation was well predicted; the magnitude and spectral shape were reasonably well predicted. Agreement was best when the distribution of sound energy across the inlet was taken into account in the performance predictions. Tests in which the length of treatment was varied showed an orderly progression of attenuation with length; performance predictions for the different lengths also showed an orderly progression with length. At the highest speed of the engine, multiple pure tones were present throughout the spectrum in the source noise signature. These tones were effectively suppressed by the inlet liner, even at low frequencies, although the liner was designed to work best at the blade-passing frequency.

  18. BOREAS TF-10 NSA-Fen Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    McCaughey, J. Harry; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Jelinski, Dennis E.

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from 08-Apr to 23-Sep at the fen site. A very limited experiment was run in the spring/ summer of 1995, when the fen site tower was operated from 08-Apr to 14-Jun in support of a hydrology experiment in an adjoining feeder basin. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the fen site was operated in 1996 in order to collect data from spring melt to autumn freeze-up. Data were collected from 29-Apr to 05-Nov at the fen site. All variables are presented as 30-minute averages. The data are stored in tabular ASCII files.

  19. Thermo-hydraulic analyses associated with a CEA design proposal for a DEMO TF conductor

    NASA Astrophysics Data System (ADS)

    Vallcorba, R.; Lacroix, B.; Ciazynski, D.; Torre, A.; Nunio, F.; Zani, L.; Le Coz, Q.; Lewandowska, M.; Coleman, M.

    2016-12-01

    The future DEMO Toroidal Field (TF) magnets are likely to feature cable-in-conduit conductors (CICC) cooled by forced flow of supercritical helium. Design activities were carried out at CEA to provide a winding pack compatible with DEMO plant requirements. The CEA proposal comprises, for each of the 16 D-shaped windings, 10 double-pancakes (2 × 392 m long) wound in 10 turns. The conductor is a square-shaped Nb3Sn double channel conductor with a central spiral, carrying a nominal current of 95.5 kA. We present a thermo-hydraulic analyses focused on the central, most critical pancake, where the maximum field is reached, aiming at evaluating the integrity of the proposed conductor design. Both normal and off-normal simulations were performed using detailed electromagnetic and neutron heating load maps as input, and evaluating operational quantities such as the temperature margin in burn conditions, and the hot spot temperature in quench conditions. We assessed the sensitivity of these quantities to some driving parameters, notably mass flow rate and the choice of friction factor correlation for the temperature margin, and quench initiation features for the hot spot temperature. Furthermore, the influence of the casing cooling on the temperature margin is analyzed. The study is carried out using two thermohydraulic models.

  20. BOREAS TF-10 NSA-YJP Tower Flux, Meteorological, and Porometry Data

    NASA Technical Reports Server (NTRS)

    McCaughey, J. Harry; Liblik, Laura; Hall, Forrest G. (Editor); Huemmrich, K. (Editor)

    2000-01-01

    The BOREAS TF-10 team collected tower flux and meteorological data at two sites, a fen and a young jack pine forest, near Thompson, Manitoba, Canada, as part of BOREAS. A preliminary data set was assembled in August 1993 while field testing the instrument packages, and at both sites data were collected from 15-Aug to 31-Aug. The main experimental period was in 1994, when continuous data were collected from the young jack pine site from 23-May to 20-Sep. Upon examination of the 1994 data set, it became clear that the behavior of the heat, water, and carbon dioxide fluxes throughout the whole growing season was an important scientific question, and that the 1994 data record was not sufficiently long to capture the character of the seasonal behavior of the fluxes. Thus, the young jack pine site was operated from 08-May to 07-Nov in 1996 in order to collect data from spring melt to autumn freeze-up. All variables are presented as 30-minute averages. Supporting data were also collected to describe the surface#s state and to provide the information, in association with the flux data, to build SVAT models. For the young jack pine site, these supporting data included stomatal conductance measurements. The data are stored in tabular ASCII files.

  1. Numerical investigation of buoyancy effects in vertical ITER-TF-CICC at normal operating conditions

    NASA Astrophysics Data System (ADS)

    Pasler, Volker

    2006-07-01

    Increasing the size of an experimental fusion device is an important factor towards achieving plasma ignition conditions; this could however generate new problems such as the build up of buoyancy flow in long, vertical parts of cable-in-conduit conductors (CICC). In this article, the impact of buoyancy effects to the conductor cooling behaviour is simulated for a conductor part at an inner leg of an ITER TF coil. The MAGS code system had to be extended by a two-channel thermohydraulic model based on the model of the MITHRANDIR code. Additionally, gravity was included. Using realistic nuclear heating assumptions, buoyancy flow shows no significant impact to the coil operation temperature margins, even if the thermal coupling is restricted to convective heat transfer between hole and bundle. The time constant of the buoyancy flow build up is of the same order of magnitude of a typical ITER cycle. An example with artificially enhanced nuclear heating by a factor of four is also included for the illustration of consequences of buoyancy effects to CICC vertical flow.

  2. Robust Inference of Genetic Exchange Communities from Microbial Genomes Using TF-IDF

    PubMed Central

    Cong, Yingnan; Chan, Yao-ban; Phillips, Charles A.; Langston, Michael A.; Ragan, Mark A.

    2017-01-01

    Bacteria and archaea can exchange genetic material across lineages through processes of lateral genetic transfer (LGT). Collectively, these exchange relationships can be modeled as a network and analyzed using concepts from graph theory. In particular, densely connected regions within an LGT network have been defined as genetic exchange communities (GECs). However, it has been problematic to construct networks in which edges solely represent LGT. Here we apply term frequency-inverse document frequency (TF-IDF), an alignment-free method originating from document analysis, to infer regions of lateral origin in bacterial genomes. We examine four empirical datasets of different size (number of genomes) and phyletic breadth, varying a key parameter (word length k) within bounds established in previous work. We map the inferred lateral regions to genes in recipient genomes, and construct networks in which the nodes are groups of genomes, and the edges natively represent LGT. We then extract maximum and maximal cliques (i.e., GECs) from these graphs, and identify nodes that belong to GECs across a wide range of k. Most surviving lateral transfer has happened within these GECs. Using Gene Ontology enrichment tests we demonstrate that biological processes associated with metabolism, regulation and transport are often over-represented among the genes affected by LGT within these communities. These enrichments are largely robust to change of k. PMID:28154557

  3. Measurements and predictions of flyover and static noise of a TF30 afterburning turbofan engine

    NASA Technical Reports Server (NTRS)

    Burcham, F. W., Jr.; Lasagna, P. L.; Oas, S. C.

    1978-01-01

    The noise of the TF30 afterburning turbofan engine in an F-111 airplane was determined from static (ground) and flyover tests. A survey was made to measure the exhaust temperature and velocity profiles for a range of power settings. Comparisons were made between predicted and measured jet mixing, internal, and shock noise. It was found that the noise produced at static conditions was dominated by jet mixing noise, and was adequately predicted by current methods. The noise produced during flyovers exhibited large contributions from internally generated noise in the forward arc. For flyovers with the engine at nonafterburning power, the internal noise, shock noise, and jet mixing noise were accurately predicted. During flyovers with afterburning power settings, however, additional internal noise believed to be due to the afterburning process was evident; its level was as much as 8 decibels above the nonafterburning internal noise. Power settings that produced exhausts with inverted velocity profiles appeared to be slightly less noisy than power settings of equal thrust that produced uniform exhaust velocity profiles both in flight and in static testing.

  4. Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma.

    PubMed

    Samantarrai, Devyani; Sahu, Mousumi; Roy, Jyoti; Mohanty, Bedanta Ballav; Singh, Garima; Bhushan, Chandra; Mallick, Bibekanand

    2015-05-18

    Cancer metastasis is a disease of extreme clinical relevance, as it is responsible for more than 90% of cancer-associated mortality. The molecular mechanism and critical regulators involved in this complex multi-stage process of metastasis is poorly deciphered in soft tissue sarcomas (STS), a heterogeneous group of rare tumors with high metastatic potential. Therefore, we aimed at identifying miRNA and transcription factor (TF) regulatory networks and paths in STS metastasis. We integrated mRNA and miRNA expression profiles with curated regulations (TF→gene, TF→miRNA, miRNA→gene) from different databases and constructed a potentially active regulatory sub-network in STS metastasis. From functional and topological analysis, we found nine novel regulators of Notch signaling sub-network which are conjectured to play critical role in metastasis of STS. This illustrated that the sub-network is promising for identification of critical regulators. Further analysis deploying our developed tool 'RiNAcyc' and computing coverage ratio of known STS associated genes and miRNAs identified a 15 node active path. This potential path highlights the crucial role of BMP2, hsa-miR-24, AP2 and MYC as the up-stream regulators of the path and hsa-miR-215 and TYMS as potential indicator of chemotherapeutic benefit in STS metastasis.

  5. FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells

    PubMed Central

    Bourseguin, Julie; Bonet, Caroline; Renaud, Emilie; Pandiani, Charlotte; Boncompagni, Marina; Giuliano, Sandy; Pawlikowska, Patrycja; Karmous-Benailly, Houda; Ballotti, Robert; Rosselli, Filippo; Bertolotto, Corine

    2016-01-01

    Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associated transcription factor (MiTF). We show that MiTF downregulation in melanoma cells lowers the expression of several FANC genes and proteins. Moreover, we observe that, similarly to the consequence of MiTF downregulation, FANC pathway silencing alters proliferation, migration and senescence of human melanoma cells. We demonstrate that the FANC pathway acts downstream MiTF and establish the existence of an epistatic relationship between MiTF and the FANC pathway. Our findings point to a central role of the FANC pathway in cellular and chromosomal resistance to both DNA damage and targeted therapies in melanoma cells. Thus, the FANC pathway is a promising new therapeutic target in melanoma treatment. PMID:27827420

  6. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 954.18 Section... and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions of... conclusions of law with supporting reasons. When the proposed findings and conclusions are not...

  7. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 954.18 Section... and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions of... conclusions of law with supporting reasons. When the proposed findings and conclusions are not...

  8. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 954.18 Section... and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions of... conclusions of law with supporting reasons. When the proposed findings and conclusions are not...

  9. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 954.18 Section... and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions of... conclusions of law with supporting reasons. When the proposed findings and conclusions are not...

  10. 39 CFR 954.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 954.18 Section... and conclusions. (a) A party to a proceeding may submit proposed findings of fact and conclusions of... conclusions of law with supporting reasons. When the proposed findings and conclusions are not...

  11. Low home cage social behaviors in BTBR T+tf/J mice during juvenile development.

    PubMed

    Babineau, Brooke A; Yang, Mu; Berman, Robert F; Crawley, Jacqueline N

    2013-04-10

    BTBR T+tf/J (BTBR) is a genetically homogenous inbred strain of mice that displays abnormal social behaviors, deficits in vocalizations, and high levels of repetitive behaviors, relevant to the three diagnostic symptoms of autism spectrum disorder, leading to the use of this strain as a mouse model of autism. Comprehensive observations of BTBR social behaviors within the home cage during early stages of development have not been conducted. Here we evaluate the home cage behaviors of BTBR in two laboratory environments (NIMH, Bethesda, Maryland vs. UC Davis, Davis, California), starting from the day of weaning and continuing into adulthood. Extensive ethogram parameters were scored for BTBR in home cages that contained four BTBR conspecifics, versus home cages that contained four C57BL/6J (B6) conspecifics. BTBR were considerably less interactive than B6 in the home cage at both sites, as measured during the early dark stage of their circadian cycle. A novel home cage behavioral measure, frequency of long interactions, was found to be more frequent and of longer duration in B6 versus BTBR home cages across experimental sites. Significant strain differences in the occurrence of investigative and affiliative behaviors were also seen, however these findings were not fully consistent across the two testing sites. At the end of the 30-day home cage observation period, each seven-week old subject mouse was tested in the three-chambered social approach task. BTBR displayed lack of sociability and B6 displayed significant sociability, consistent with previous reports. Our findings reveal that BTBR engaged in lower levels of some components of spontaneous conspecific social interactions in the home cage environment throughout juvenile development, consistent with their deficits in juvenile and adult sociability as measured in specialized social tasks.

  12. Pacer Comet 4: Automated Jet Engine Testing of a TF33-P100 Pratt & Whitney Engine

    NASA Astrophysics Data System (ADS)

    Mason, Rex Bolding

    Pacer Comet 4 found its life out of necessity to replace an obsolescent Pacer Comet 3 engine test system at Tinker AFB in Oklahoma City, OK. Pacer Comet 3 (PC3) was created and installed in the early 1980's to test jet engines from a wide range of planes. PC3 had several problems from a maintenance standpoint: contractors designed and installed the system but the contract did not include the OEM data package. Without drawings or design knowledge, fixing the smallest of problems could turn into a multi-day project. In addition to high cost, as the OEM companies of proprietary parts went out of business, it became impossible to find a replacement for a failed part. These issues set the framework for the Pacer Comet 4 (PC4) system. PC4 was created as an organic AF and Department of Defense collaboration to fix the issues with PC3. PC4 provides the customer with a complete data package including multiple drawing sets and data sheets for all parts used, as well as design files for all PCBs created in house. PC4 has a standard to use commercially available off the shelf parts (COTS). The reason for this is sustainability in maintenance. If a part is to fail, it should be able to be purchased from any manufacturer that meets the specs of the original product. No proprietary parts are used, except as directed by the engine's OEM. This thesis will focus on the design and installation of the on-frame data acquisition PC4 system for the Pratt & Whitney TF33-P100A-QEC engine that is currently in use on the E3 Sentry. This thesis will show efficiency improvements for maintenance sustainability (70% cabling reduction) as well as discuss performance improvements in both test and production environments.

  13. Fusion of Potentiometric & Voltammetric Electronic Tongue for Classification of Black Tea Taste based on Theaflavins (TF) Content

    NASA Astrophysics Data System (ADS)

    Bhattacharyya, Nabarun; Legin, Andrey; Papieva, Irina; Sarkar, Subrata; Kirsanov, Dmitry; Kartsova, Anna; Ghosh, Arunangshu; Bandyopadhyay, Rajib

    2011-09-01

    Black tea is an extensively consumed beverage worldwide with an expanding market. The final quality of black tea depends upon number of chemical compounds present in the tea. Out of these compounds, theaflavins (TF), which is responsible for astringency in black tea, plays an important role in determining the final taste of the finished black tea. The present paper reports our effort to correlate the theaflavins contents with the voltammetric and potentiometric electronic tongue (e-tongue) data. Noble metal-based electrode array has been used for collecting data though voltammetric electronic tongue where as liquid filled membrane based electrodes have been used for potentiometric electronic tongue. Black tea samples with tea taster score and biochemical results have been collected from Tea Research Association, Tocklai, India for the analysis purpose. In this paper, voltammetric and potentiometric e-tongue responses are combined to demonstrate improvement of cluster formation among tea samples with different ranges of TF values.

  14. Implementation of non-condensable gases condensation suppression model into the WCOBRA/TRAC-TF2 LOCA safety evaluation code

    SciTech Connect

    Liao, J.; Cao, L.; Ohkawa, K.; Frepoli, C.

    2012-07-01

    The non-condensable gases condensation suppression model is important for a realistic LOCA safety analysis code. A condensation suppression model for direct contact condensation was previously developed by Westinghouse using first principles. The model is believed to be an accurate description of the direct contact condensation process in the presence of non-condensable gases. The Westinghouse condensation suppression model is further revised by applying a more physical model. The revised condensation suppression model is thus implemented into the WCOBRA/TRAC-TF2 LOCA safety evaluation code for both 3-D module (COBRA-TF) and 1-D module (TRAC-PF1). Parametric study using the revised Westinghouse condensation suppression model is conducted. Additionally, the performance of non-condensable gases condensation suppression model is examined in the ACHILLES (ISP-25) separate effects test and LOFT L2-5 (ISP-13) integral effects test. (authors)

  15. 17 CFR 10.82 - Proposed findings and conclusions; briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... conclusions; briefs. 10.82 Section 10.82 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE Hearings § 10.82 Proposed findings and conclusions; briefs. In any proceeding... and conclusions of law. Briefs may be filed in support of proposed findings and conclusions either...

  16. Oxides of Nitrogen Emissions from the Testing of TF41-A-2B Engines at Naval Air Station, Lemoore, California

    DTIC Science & Technology

    1987-11-01

    for each engine test run. The procedure involves the use of a correlation coefficient which relates the weight (pounds) of NOx emissions to the...individual engines. This report establishes a correlation coefficient for the TF41-A-2B engine based on actual emissions data and the run sheets from 27...engine tests conducted in test cells at NAS Lemoore, CA. The correlation coefficient , equal to 0.01515 pounds of NOx formed per pound of fuel consumed

  17. The New York City Urban Search and Rescue Team (NY-TF1): A Case Study of Interagency Effectiveness

    DTIC Science & Technology

    2011-03-01

    somewhere else in the U.S. necessitating search and rescue of collapsed structures. The terrorist attacks on the World Trade Center ( WTC ) in NYC and the...officers has deployed to hurricanes, terrorist bombings, major structural collapses and, most recently, to the earthquake in Haiti where the team...for rescue operations at structural collapse . The NY-TF1 model offers insight into how the FDNY and NYPD can cooperate at emergency operations on

  18. Preliminary LOCA analysis of the westinghouse small modular reactor using the WCOBRA/TRAC-TF2 thermal-hydraulics code

    SciTech Connect

    Liao, J.; Kucukboyaci, V. N.; Nguyen, L.; Frepoli, C.

    2012-07-01

    The Westinghouse Small Modular Reactor (SMR) is an 800 MWt (> 225 MWe) integral pressurized water reactor (iPWR) with all primary components, including the steam generator and the pressurizer located inside the reactor vessel. The reactor core is based on a partial-height 17x17 fuel assembly design used in the AP1000{sup R} reactor core. The Westinghouse SMR utilizes passive safety systems and proven components from the AP1000 plant design with a compact containment that houses the integral reactor vessel and the passive safety systems. A preliminary loss of coolant accident (LOCA) analysis of the Westinghouse SMR has been performed using the WCOBRA/TRAC-TF2 code, simulating a transient caused by a double ended guillotine (DEG) break in the direct vessel injection (DVI) line. WCOBRA/TRAC-TF2 is a new generation Westinghouse LOCA thermal-hydraulics code evolving from the US NRC licensed WCOBRA/TRAC code. It is designed to simulate PWR LOCA events from the smallest break size to the largest break size (DEG cold leg). A significant number of fluid dynamics models and heat transfer models were developed or improved in WCOBRA/TRAC-TF2. A large number of separate effects and integral effects tests were performed for a rigorous code assessment and validation. WCOBRA/TRAC-TF2 was introduced into the Westinghouse SMR design phase to assist a quick and robust passive cooling system design and to identify thermal-hydraulic phenomena for the development of the SMR Phenomena Identification Ranking Table (PIRT). The LOCA analysis of the Westinghouse SMR demonstrates that the DEG DVI break LOCA is mitigated by the injection and venting from the Westinghouse SMR passive safety systems without core heat up, achieving long term core cooling. (authors)

  19. The non-structural protein Nsp2TF of porcine reproductive and respiratory syndrome virus down-regulates the expression of Swine Leukocyte Antigen class I.

    PubMed

    Cao, Qian M; Subramaniam, Sakthivel; Ni, Yan-Yan; Cao, Dianjun; Meng, Xiang-Jin

    2016-04-01

    Porcine reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically-important global swine pathogen. Here we demonstrated that PRRSV down-regulates Swine Leukocyte Antigen class I (SLA-I) expression in porcine alveolar macrophages, PK15-CD163 cells and monocyte-derived dendritic cells. To identify the viral protein(s) involved in SLA-I down-regulation, we tested all 22 PRRSV structural and non-structural proteins and identified that Nsp1α and Nsp2TF, and GP3 significantly down-regulated SLA-I expression with Nsp2TF showing the greatest effect. We further generated a panel of mutant viruses in which the Nsp2TF protein synthesis was abolished, and found that the two mutants with disrupted -2 ribosomal frameshifting elements and additional stop codons in the TF domain were unable to down-regulate SLA-I expression. Additionally we demonstrated that the last 68 amino acids of TF domain in Nsp2TF are critical for this function. Collectively, the results indicate a novel function of Nsp2TF in negative modulation of SLA-I expression.

  20. Non-nuclear Testing of Reactor Systems in the Early Flight Fission Test Facilities (EFF-TF)

    NASA Technical Reports Server (NTRS)

    VanDyke, Melissa; Martin, James

    2004-01-01

    The Early Flight Fission-Test Facility (EFF-TF) can assist in the &sign and development of systems through highly effective non-nuclear testing of nuclear systems when technical issues associated with near-term space fission systems are "non-nuclear" in nature (e.g. system s nuclear operations are understood). For many systems. thermal simulators can he used to closely mimic fission heat deposition. Axial power profile, radial power profile. and fuel pin thermal conductivity can be matched. In addition to component and subsystem testing, operational and lifetime issues associated with the steady state and transient performance of the integrated reactor module can be investigated. Instrumentation at the EFF-TF allows accurate measurement of temperature, pressure, strain, and bulk core deformation (useful for accurately simulating nuclear behavior). Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE laboratories, industry, universities, and other NASA centers. This paper describes the current efforts for the latter portion of 2003 and beginning of 2004.

  1. AVAQ 594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis.

    PubMed

    Hattori, Ai; Wakusawa, Shinnya; Hayashi, Hisao; Harashima, Ai; Sanae, Fujiko; Kawanaka, Miwa; Yamada, Gohtaro; Yano, Motoyashi; Yoshioka, Kenntaro

    2003-06-01

    The majority of Caucasian patients with hemochromatosis are homozygous for C282Y mutation of the HFE gene. In contrast to its high prevalence in Caucasians, hemochromatosis is a rare disorder in Japan. This may be due to the low prevalence of the C282Y mutation of the HFE gene in Japanese. Recent reports suggest that the mutations of transferrin receptor 2 (TfR2) gene may be involved in non-HFE hemochromatosis. Therefore, we investigated the TfR2 gene of 6 sporadic and 5 familiar cases of Japanese hemochromatosis. Three siblings in one family were found to be homozygous for an AVAQ 594-597 deletion. All three had severe iron deposits in the hepatocytes and bile ducts, but none was affected by diabetes mellitus. This mutation was not detected in 100 control individuals. Further study was undertaken to investigate whether the large deletion of the TfR2 gene is the mutation responsible for some of the Japanese hemochromatosis cases.

  2. Early Flight Fission Test Facilities (EFF-TF) and Concepts That Support Near-Term Space Fission Missions

    NASA Technical Reports Server (NTRS)

    VanDyke, Melissa; Houts, Mike; Godfroy, Thomas; Martin, James

    2003-01-01

    Fission technology can enable rapid, affordable access to any point in the solar system. If fusion propulsion systems are to be developed to their full potential; however, near-term customers must be identified and initial fission systems successfully developed, launched, and utilized. Successful utilization will most likely occur if frequent, significant hardware-based milestones can be achieved throughout the program. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system pe$ormance and lifetime can be attained through non-nuclear testing. Through demonstration of systems concepts (designed by DOE National Laboratories) in relevant environments, this philosophy has been demonstrated through hardware testing in the Early Flight Fission Test Facilities (EFF-TF) at the Marshall Space Flight Center. The EFF-TF is designed to enable very realistic non-nuclear testing of space fission systems. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers.

  3. Person Reliability

    ERIC Educational Resources Information Center

    Lumsden, James

    1977-01-01

    Person changes can be of three kinds: developmental trends, swells, and tremors. Person unreliability in the tremor sense (momentary fluctuations) can be estimated from person characteristic curves. Average person reliability for groups can be compared from item characteristic curves. (Author)

  4. 2015 Southern Taurid fireballs and asteroids 2005 UR and 2005 TF50

    NASA Astrophysics Data System (ADS)

    Olech, A.; Żołądek, P.; Wiśniewski, M.; Rudawska, R.; Bęben, M.; Krzyżanowski, T.; Myszkiewicz, M.; Stolarz, M.; Gawroński, M.; Gozdalski, M.; Suchodolski, T.; Węgrzyk, W.; Tymiński, Z.

    2016-09-01

    On the night of October 31, 2015 two bright Southern Taurid fireballs occurred over Poland, being one of the most spectacular bolides of this shower in recent years. The first fireball - PF311015a Okonek - was detected by six video stations of Polish Fireball Network (PFN) and photographed by several bystanders, allowing for precise determination of the trajectory and orbit of the event. The PF311015a Okonek entered Earth's atmosphere with the velocity of 33.2 ± 0.1 km s-1 and started to shine at height of 117.88 ± 0.05 km. The maximum brightness of -16.0 ± 0.4 mag was reached at height of 82.5 ± 0.1 km. The trajectory of the fireball ended at height of 60.2 ± 0.2 km with terminal velocity of 30.2 ± 1.0 km s-1. The second fireball - PF311015b Ostrowite - was detected by six video stations of PFN. It started with velocity of 33.2 ± 0.1 km s-1 at height of 108.05 ± 0.02 km. The peak brightness of -14.8 ± 0.5 mag was recorded at height of 82.2 ± 0.1 km. The terminal velocity was 31.8 ± 0.5 km s-1 and was observed at height of 57.86 ± 0.03 km. The orbits of both fireballs are similar not only to orbits of Southern Taurids and comet 2P/Encke, but even closer resemblance was noticed for orbits of 2005 UR and 2005 TF50 asteroids. Especially the former object is interesting because of its close flyby during spectacular Taurid maximum in 2005. We carried out a further search to investigate the possible genetic relationship of Okonek and Ostrowite fireballs with both asteroids, that are considered to be associated with Taurid complex. Although, we could not have confirmed unequivocally the relation between fireballs and these objects, we showed that both asteroids could be associated, having the same origin in a disruption process that separates them.

  5. Development of uncertainty methodology for COBRA-TF void distribution and critical power predictions

    NASA Astrophysics Data System (ADS)

    Aydogan, Fatih

    specimens among the sample with a bias lower than the experimental uncertainty. Besides, the rankings of dominant phenomena are observed with the second comparison method (sensitivity analysis). Simple Random Sampling, Order Statistics, Richardson Extrapolation are some of the methods that are in the developed methodology. This uncertainty methodology was implemented for the COBRA-TF predictions. The uncertainty and sensitivity results are presented in the dissertation.

  6. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 8... conclusions. Except in cases when the respondent has failed to answer the complaint or when a party has failed... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  7. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 6 2013-10-01 2013-10-01 false Proposed findings, conclusions, and order. 511.46... Proposed findings, conclusions, and order. Within a reasonable time after the closing of the record and..., including proposed findings of fact, conclusions of law and a proposed order, together with...

  8. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 6 2012-10-01 2012-10-01 false Proposed findings, conclusions, and order. 511.46... Proposed findings, conclusions, and order. Within a reasonable time after the closing of the record and..., including proposed findings of fact, conclusions of law and a proposed order, together with...

  9. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  10. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  11. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  12. 16 CFR 1025.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Proposed findings, conclusions, and order... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 1025.46 Proposed findings, conclusions, and order. Within..., including proposed findings of fact and conclusions of law, as well as a proposed order. The...

  13. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each..., conclusions of law, orders and supporting reasons either in oral or written form in the discretion of...

  14. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 6 2014-10-01 2014-10-01 false Proposed findings, conclusions, and order. 511.46... Proposed findings, conclusions, and order. Within a reasonable time after the closing of the record and..., including proposed findings of fact, conclusions of law and a proposed order, together with...

  15. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  16. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 8... conclusions. Except in cases when the respondent has failed to answer the complaint or when a party has failed... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  17. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Proposed findings, conclusions and orders. 2700.65 Section... COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of fact, conclusions of law, and orders, together...

  18. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 15... conclusions. Except in cases where the respondent has failed to answer the complaint or where a party has... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  19. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  20. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 15... conclusions. Except in cases where the respondent has failed to answer the complaint or where a party has... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  1. 17 CFR 10.82 - Proposed findings and conclusions; briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... conclusions; briefs. 10.82 Section 10.82 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... conclusions; briefs. In any proceeding involving a hearing or an opportunity for hearing, the parties may file written proposed findings of fact and conclusions of law. Briefs may be filed in support of...

  2. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  3. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Proposed findings, conclusions, and.../TERMINATION OR SUSPENSION OF PERMITS Hearing Procedures § 22.26 Proposed findings, conclusions, and order. After the hearing, any party may file proposed findings of fact, conclusions of law, and a...

  4. 40 CFR 209.29 - Proposed findings, conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Proposed findings, conclusions. 209.29..., conclusions. (a) Within 20 days of the filing of the record with the hearing clerk as provided in § 209.28, or... consideration of the administrative law judge proposed findings of fact, conclusions of law, and a proposed...

  5. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Proposed findings, conclusions, and order. 672.19... FOUNDATION ENFORCEMENT AND HEARING PROCEDURES § 672.19 Proposed findings, conclusions, and order. Unless otherwise ordered by the Presiding Officer, any party may submit proposed findings of fact, conclusions...

  6. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... conclusions. 251.52 Section 251.52 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs, or...

  7. 16 CFR 1025.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Proposed findings, conclusions, and order... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 1025.46 Proposed findings, conclusions, and order. Within..., including proposed findings of fact and conclusions of law, as well as a proposed order. The...

  8. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 15... conclusions. Except in cases where the respondent has failed to answer the complaint or where a party has... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  9. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 8... conclusions. Except in cases when the respondent has failed to answer the complaint or when a party has failed... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  10. 16 CFR 1025.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Proposed findings, conclusions, and order... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 1025.46 Proposed findings, conclusions, and order. Within..., including proposed findings of fact and conclusions of law, as well as a proposed order. The...

  11. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Proposed findings, conclusions and orders. 2700.65 Section... COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of fact, conclusions of law, and orders, together...

  12. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  13. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 10... and conclusions. Except in cases where the respondent has failed to answer the complaint or where a... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  14. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  15. 16 CFR 3.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Proposed findings, conclusions, and order. 3... PRACTICE RULES OF PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 3.46 Proposed findings, conclusions, and... Secretary for consideration of the Administrative Law Judge proposed findings of fact, conclusions of...

  16. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  17. 16 CFR 3.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Proposed findings, conclusions, and order. 3... PRACTICE RULES OF PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 3.46 Proposed findings, conclusions, and... Secretary for consideration of the Administrative Law Judge proposed findings of fact, conclusions of...

  18. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Proposed findings, conclusions and orders. 2700.65 Section... COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of fact, conclusions of law, and orders, together...

  19. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 10... and conclusions. Except in cases where the respondent has failed to answer the complaint or where a... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  20. 16 CFR 1025.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Proposed findings, conclusions, and order... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 1025.46 Proposed findings, conclusions, and order. Within..., including proposed findings of fact and conclusions of law, as well as a proposed order. The...

  1. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 8... conclusions. Except in cases when the respondent has failed to answer the complaint or when a party has failed... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  2. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Proposed findings, conclusions, and.../TERMINATION OR SUSPENSION OF PERMITS Hearing Procedures § 22.26 Proposed findings, conclusions, and order. After the hearing, any party may file proposed findings of fact, conclusions of law, and a...

  3. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 10... and conclusions. Except in cases where the respondent has failed to answer the complaint or where a... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  4. 40 CFR 209.29 - Proposed findings, conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Proposed findings, conclusions. 209.29..., conclusions. (a) Within 20 days of the filing of the record with the hearing clerk as provided in § 209.28, or... consideration of the administrative law judge proposed findings of fact, conclusions of law, and a proposed...

  5. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 952.23 Section... conclusions. (a) Each party to a proceeding, except one who fails to answer the complaint or, having answered... fact, conclusions of law, orders and supporting reasons either in oral or written form in...

  6. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... conclusions. Within fifteen (15) days following the close of the hearing, the parties may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  7. 24 CFR 1720.520 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 5 2012-04-01 2012-04-01 false Proposed findings, conclusions, and... PRACTICE Adjudicatory Proceedings Hearings § 1720.520 Proposed findings, conclusions, and order. The... which any party may file with the administrative law judge proposed findings of fact, conclusions of...

  8. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 10... and conclusions. Except in cases where the respondent has failed to answer the complaint or where a... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  9. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... conclusions. Within fifteen (15) days following the close of the hearing, the parties may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  10. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  11. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  12. 24 CFR 1720.520 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Proposed findings, conclusions, and... PRACTICE Adjudicatory Proceedings Hearings § 1720.520 Proposed findings, conclusions, and order. The... which any party may file with the administrative law judge proposed findings of fact, conclusions of...

  13. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except..., conclusions of law and supporting reasons either in oral or written form. The presiding officer may...

  14. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each..., conclusions of law, orders and supporting reasons either in oral or written form in the discretion of...

  15. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  16. 16 CFR 1025.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Proposed findings, conclusions, and order... PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 1025.46 Proposed findings, conclusions, and order. Within..., including proposed findings of fact and conclusions of law, as well as a proposed order. The...

  17. 24 CFR 1720.520 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Proposed findings, conclusions, and... PRACTICE Adjudicatory Proceedings Hearings § 1720.520 Proposed findings, conclusions, and order. The... which any party may file with the administrative law judge proposed findings of fact, conclusions of...

  18. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  19. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Proposed findings, conclusions, and.../TERMINATION OR SUSPENSION OF PERMITS Hearing Procedures § 22.26 Proposed findings, conclusions, and order. After the hearing, any party may file proposed findings of fact, conclusions of law, and a...

  20. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  1. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 15... conclusions. Except in cases where the respondent has failed to answer the complaint or where a party has... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  2. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... conclusions. Within fifteen (15) days following the close of the hearing, the parties may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  3. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each... discretion of the presiding officer such is not appropriate, submit proposed findings of fact, conclusions...

  4. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  5. 39 CFR 952.23 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 952.23 Section... RELATIVE TO FALSE REPRESENTATION AND LOTTERY ORDERS § 952.23 Proposed findings and conclusions. (a) Each..., conclusions of law, orders and supporting reasons either in oral or written form in the discretion of...

  6. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and conclusions of law, briefs and...

  7. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Proposed findings, conclusions, and.../TERMINATION OR SUSPENSION OF PERMITS Hearing Procedures § 22.26 Proposed findings, conclusions, and order. After the hearing, any party may file proposed findings of fact, conclusions of law, and a...

  8. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Proposed findings, conclusions and orders. 2700.65 Section... COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of fact, conclusions of law, and orders, together...

  9. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  10. 37 CFR 251.52 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conclusions. 251.52 Section 251.52 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.52 Proposed findings and conclusions. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs, or...

  11. 24 CFR 1720.520 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 5 2014-04-01 2014-04-01 false Proposed findings, conclusions, and... PRACTICE Adjudicatory Proceedings Hearings § 1720.520 Proposed findings, conclusions, and order. The... which any party may file with the administrative law judge proposed findings of fact, conclusions of...

  12. 31 CFR 15.737-24 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 15... conclusions. Except in cases where the respondent has failed to answer the complaint or where a party has... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  13. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... conclusions. Within fifteen (15) days following the close of the hearing, the parties may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  14. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Proposed findings, conclusions, and order. 511.46... Proposed findings, conclusions, and order. Within a reasonable time after the closing of the record and..., including proposed findings of fact, conclusions of law and a proposed order, together with...

  15. 47 CFR 1.263 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Proposed findings and conclusions. 1.263... Proceedings Hearing and Intermediate Decision § 1.263 Proposed findings and conclusions. (a) Each party to the proceeding may file proposed findings of fact and conclusions, briefs, or memoranda of law: Provided,...

  16. 17 CFR 10.82 - Proposed findings and conclusions; briefs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... conclusions; briefs. 10.82 Section 10.82 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... conclusions; briefs. In any proceeding involving a hearing or an opportunity for hearing, the parties may file written proposed findings of fact and conclusions of law. Briefs may be filed in support of...

  17. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Proposed findings, conclusions, and order. 672.19... FOUNDATION ENFORCEMENT AND HEARING PROCEDURES § 672.19 Proposed findings, conclusions, and order. Unless otherwise ordered by the Presiding Officer, any party may submit proposed findings of fact, conclusions...

  18. 16 CFR 3.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Proposed findings, conclusions, and order. 3... PRACTICE RULES OF PRACTICE FOR ADJUDICATIVE PROCEEDINGS Hearings § 3.46 Proposed findings, conclusions, and... Secretary for consideration of the Administrative Law Judge proposed findings of fact, conclusions of...

  19. 24 CFR 1720.520 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 5 2013-04-01 2013-04-01 false Proposed findings, conclusions, and... PRACTICE Adjudicatory Proceedings Hearings § 1720.520 Proposed findings, conclusions, and order. The... which any party may file with the administrative law judge proposed findings of fact, conclusions of...

  20. 29 CFR 2700.65 - Proposed findings, conclusions and orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Proposed findings, conclusions and orders. 2700.65 Section... COMMISSION PROCEDURAL RULES Hearings § 2700.65 Proposed findings, conclusions and orders. The Judge may require the submission of proposed findings of fact, conclusions of law, and orders, together...

  1. 40 CFR 209.29 - Proposed findings, conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Proposed findings, conclusions. 209.29..., conclusions. (a) Within 20 days of the filing of the record with the hearing clerk as provided in § 209.28, or... consideration of the administrative law judge proposed findings of fact, conclusions of law, and a proposed...

  2. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  3. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except..., conclusions of law and supporting reasons either in oral or written form. The presiding officer may...

  4. 29 CFR 458.87 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Proposed findings and conclusions. 458.87 Section 458.87... conclusions. Within fifteen (15) days following the close of the hearing, the parties may submit proposed findings and conclusions to the Administrative Law Judge, together with supporting reasons therefor,...

  5. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except..., conclusions of law and supporting reasons either in oral or written form. The presiding officer may...

  6. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and conclusions of law, briefs and...

  7. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Proposed findings and conclusions. 111.68 Section... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions. The... record in which to submit proposed findings and conclusions and supporting reasons for the findings...

  8. 31 CFR 10.75 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 10... and conclusions. Except in cases where the respondent has failed to answer the complaint or where a... submit proposed findings and conclusions and their supporting reasons to the Administrative Law Judge....

  9. 39 CFR 957.20 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 957.20 Section... RELATIVE TO DEBARMENT AND SUSPENSION FROM CONTRACTING § 957.20 Proposed findings and conclusions. (a) Each... the Judicial Officer such is not appropriate, submit proposed findings of fact, conclusions of law...

  10. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  11. 39 CFR 3001.35 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 3001.35 Section... General Applicability § 3001.35 Proposed findings and conclusions. The Commission or the presiding officer may direct the filing of proposed findings and conclusions with a brief statement of the...

  12. 40 CFR 209.29 - Proposed findings, conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Proposed findings, conclusions. 209.29..., conclusions. (a) Within 20 days of the filing of the record with the hearing clerk as provided in § 209.28, or... consideration of the administrative law judge proposed findings of fact, conclusions of law, and a proposed...

  13. 40 CFR 22.26 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Proposed findings, conclusions, and.../TERMINATION OR SUSPENSION OF PERMITS Hearing Procedures § 22.26 Proposed findings, conclusions, and order. After the hearing, any party may file proposed findings of fact, conclusions of law, and a...

  14. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except..., conclusions of law and supporting reasons either in oral or written form. The presiding officer may...

  15. 31 CFR 8.67 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Proposed findings and conclusions. 8... conclusions. Except in cases when the respondent has failed to answer the complaint or when a party has failed... afford the parties a reasonable opportunity to submit proposed findings and conclusions and...

  16. 39 CFR 959.22 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings and conclusions. 959.22 Section... RELATIVE TO THE PRIVATE EXPRESS STATUTES § 959.22 Proposed findings and conclusions. (a) Each party, except..., conclusions of law and supporting reasons either in oral or written form. The presiding officer may...

  17. 17 CFR 10.82 - Proposed findings and conclusions; briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... conclusions; briefs. 10.82 Section 10.82 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... conclusions; briefs. In any proceeding involving a hearing or an opportunity for hearing, the parties may file written proposed findings of fact and conclusions of law. Briefs may be filed in support of...

  18. 40 CFR 209.29 - Proposed findings, conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Proposed findings, conclusions. 209.29..., conclusions. (a) Within 20 days of the filing of the record with the hearing clerk as provided in § 209.28, or... consideration of the administrative law judge proposed findings of fact, conclusions of law, and a proposed...

  19. 17 CFR 10.82 - Proposed findings and conclusions; briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... conclusions; briefs. 10.82 Section 10.82 Commodity and Securities Exchanges COMMODITY FUTURES TRADING... conclusions; briefs. In any proceeding involving a hearing or an opportunity for hearing, the parties may file written proposed findings of fact and conclusions of law. Briefs may be filed in support of...

  20. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Proposed findings and conclusions. 901.48... Termination of Enrollment § 901.48 Proposed findings and conclusions. Except in cases where the respondent has... proposed findings and conclusions and supporting reasons therefor....

  1. An Extension of Holland's Theory to its Unnatural Conclusion

    ERIC Educational Resources Information Center

    Hollifield, John H.

    1971-01-01

    A factitious description of the destruction of the United States is given with the blame being placed on the author's theory of vocational choice and its disastrous results. The theory is based on dividing all people into personality types and all occupations into categories, and matching the two groups. (CG)

  2. Asking the Right Questions about Leadership: Discussion and Conclusions

    ERIC Educational Resources Information Center

    Hackman, J. Richard; Wageman, Ruth

    2007-01-01

    Five questions prompted by the articles in the American Psychologist special issue on leadership (January 2007, Vol. 62, No. 1) suggest some new directions for leadership research: (1) Not do leaders make a difference, but under what conditions does leadership matter? (2) Not what are the traits of leaders, but how do leaders' personal attributes…

  3. Improvement of COBRA-TF for modeling of PWR cold- and hot-legs during reactor transients

    NASA Astrophysics Data System (ADS)

    Salko, Robert K.

    COBRA-TF is a two-phase, three-field (liquid, vapor, droplets) thermal-hydraulic modeling tool that has been developed by the Pacific Northwest Laboratory under sponsorship of the NRC. The code was developed for Light Water Reactor analysis starting in the 1980s; however, its development has continued to this current time. COBRA-TF still finds wide-spread use throughout the nuclear engineering field, including nuclear-power vendors, academia, and research institutions. It has been proposed that extension of the COBRA-TF code-modeling region from vessel-only components to Pressurized Water Reactor (PWR) coolant-line regions can lead to improved Loss-of-Coolant Accident (LOCA) analysis. Improved modeling is anticipated due to COBRA-TF's capability to independently model the entrained-droplet flow-field behavior, which has been observed to impact delivery to the core region[1]. Because COBRA-TF was originally developed for vertically-dominated, in-vessel, sub-channel flow, extension of the COBRA-TF modeling region to the horizontal-pipe geometries of the coolant-lines required several code modifications, including: • Inclusion of the stratified flow regime into the COBRA-TF flow regime map, along with associated interfacial drag, wall drag and interfacial heat transfer correlations, • Inclusion of a horizontal-stratification force between adjacent mesh cells having unequal levels of stratified flow, and • Generation of a new code-input interface for the modeling of coolant-lines. The sheer number of COBRA-TF modifications that were required to complete this work turned this project into a code-development project as much as it was a study of thermal-hydraulics in reactor coolant-lines. The means for achieving these tasks shifted along the way, ultimately leading the development of a separate, nearly completely independent one-dimensional, two-phase-flow modeling code geared toward reactor coolant-line analysis. This developed code has been named CLAP, for

  4. Overexpression of COUP-TF1 in murine embryonic stem cells reduces retinoic acid-associated growth arrest and increases extraembryonic endoderm gene expression.

    PubMed

    Zhuang, Yong; Gudas, Lorraine J

    2008-09-01

    Vitamin A (retinol [Rol]) and its metabolites are essential for embryonic development. The Rol metabolite all-trans retinoic acid (RA) is a biologically active form of Rol. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription-factors (COUP-TF) proteins have been implicated in the regulation of several important biological processes, such as embryonic development and neuronal cell differentiation. Because there is evidence that COUP-TFs function in the retinoid signaling network during development and differentiation, we generated murine embryonic stem (ES) cell lines which stably and constitutively overexpress COUP-TF1 (NR2F1) and we analyzed RA-induced differentiation. COUP-TF1 overexpression resulted in reduced RA-associated growth arrest. A 2.4+/-0.17-fold higher Nanog mRNA level was seen in COUP-TF1 overexpressing lines, as compared with wild-type (WT) ES cells, after a 72 hr RA treatment. We also showed that COUP-TF1 overexpression enhanced RA-induced extraembryonic endoderm gene expression. Specifically, COUP-TF1 overexpression increased mRNA levels of GATA6 by 3.3+/-0.3-fold, GATA4 by 3.6+/-0.1-fold, laminin B1 (LAMB1) by 3.4+/-0.1-fold, LAMC1 by 3.4+/-0.2-fold, Dab2 by 2.4+0.1-fold, and SOX17 by 2.5-fold at 72 hr after RA treatment plus LIF, as compared with the increases seen in WT ES cells. However, RA-induced neurogenesis was unaffected by COUP-TF1 overexpression, as shown by the equivalent levels of expression of NeuroD1, nestin, GAP43 and other neuronal markers. Our results revealed for the first time that COUP-TF1 is an important signaling molecule during vitamin A (Rol)-mediated very early stage of embryonic development.

  5. WISE TF: A MID-INFRARED, 3.4 {mu}m EXTENSION OF THE TULLY-FISHER RELATION USING WISE PHOTOMETRY

    SciTech Connect

    Lagattuta, David J.; Mould, Jeremy R.; Staveley-Smith, Lister; Hong Tao; Springob, Christopher M.; Masters, Karen L.; Koribalski, Baerbel S.; Jones, D. Heath

    2013-07-10

    We present a mid-infrared Tully-Fisher (TF) relation using photometry from the 3.4 {mu}m W1 band of the Wide-field Infrared Survey Explorer (WISE) satellite. The WISE TF relation is formed from 568 galaxies taken from the all-sky 2MASS Tully-Fisher (2MTF) galaxy catalog, spanning a range of environments including field, group, and cluster galaxies. This constitutes the largest mid-infrared TF relation constructed to date. After applying a number of corrections to galaxy magnitudes and line widths, we measure a master TF relation given by M{sub corr} = -22.24 - 10.05[log (W{sub corr}) - 2.5], with an average dispersion of {sigma}{sub WISE} = 0.686 mag. There is some tension between WISE TF and a preliminary 3.6 {mu}m relation, which has a shallower slope and almost no intrinsic dispersion. However, our results agree well with a more recent relation constructed from a large sample of cluster galaxies. We additionally compare WISE TF to the near-infrared 2MTF template relations, finding a good agreement between the TF parameters and total dispersions of WISE TF and the 2MTF K-band template. This fact, coupled with typical galaxy colors of (K - W1) {approx} 0, suggests that these two bands are tracing similar stellar populations, including the older, centrally-located stars in the galactic bulge which can (for galaxies with a prominent bulge) dominate the light profile.

  6. Development of burnup dependent fuel rod model in COBRA-TF

    NASA Astrophysics Data System (ADS)

    Yilmaz, Mine Ozdemir

    The purpose of this research was to develop a burnup dependent fuel thermal conductivity model within Pennsylvania State University, Reactor Dynamics and Fuel Management Group (RDFMG) version of the subchannel thermal-hydraulics code COBRA-TF (CTF). The model takes into account first, the degradation of fuel thermal conductivity with high burnup; and second, the fuel thermal conductivity dependence on the Gadolinium content for both UO2 and MOX fuel rods. The modified Nuclear Fuel Industries (NFI) model for UO2 fuel rods and Duriez/Modified NFI Model for MOX fuel rods were incorporated into CTF and fuel centerline predictions were compared against Halden experimental test data and FRAPCON-3.4 predictions to validate the burnup dependent fuel thermal conductivity model in CTF. Experimental test cases from Halden reactor fuel rods for UO2 fuel rods at Beginning of Life (BOL), through lifetime without Gd2O3 and through lifetime with Gd 2O3 and a MOX fuel rod were simulated with CTF. Since test fuel rod and FRAPCON-3.4 results were based on single rod measurements, CTF was run for a single fuel rod surrounded with a single channel configuration. Input decks for CTF were developed for one fuel rod located at the center of a subchannel (rod-centered subchannel approach). Fuel centerline temperatures predicted by CTF were compared against the measurements from Halden experimental test data and the predictions from FRAPCON-3.4. After implementing the new fuel thermal conductivity model in CTF and validating the model with experimental data, CTF model was applied to steady state and transient calculations. 4x4 PWR fuel bundle configuration from Purdue MOX benchmark was used to apply the new model for steady state and transient calculations. First, one of each high burnup UO2 and MOX fuel rods from 4x4 matrix were selected to carry out single fuel rod calculations and fuel centerline temperatures predicted by CTF/TORT-TD were compared against CTF /TORT-TD /FRAPTRAN

  7. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Conclusion of hearing. 209.35 Section 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS... Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  8. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Conclusion of hearing. 209.35 Section 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS... Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  9. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Conclusion of hearing. 209.35 Section 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS... Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  10. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... ORDERS Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  11. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Conclusion of hearing. 209.35 Section 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS... Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  12. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Proposed findings and conclusions. 2.712 Section 2.712... ORDERS Rules for Formal Adjudications § 2.712 Proposed findings and conclusions. (a) Any party to a proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  13. 40 CFR 209.35 - Conclusion of hearing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 26 2012-07-01 2011-07-01 true Conclusion of hearing. 209.35 Section 209.35 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS... Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.35 Conclusion of hearing....

  14. Move Sequences in Graduate Research Paper Introductions and Conclusions

    ERIC Educational Resources Information Center

    Madrunio, Marilu Rañosa

    2012-01-01

    Graduate students submit academic papers at the end of the term as part of their coursework. Such papers contain introduction moves which may be troublesome and conclusion moves which may contain sub-moves not really required. This paper is aimed at assessing what particular moves are employed in the introduction and conclusion sections of 21…

  15. 19 CFR 111.68 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Proposed findings and conclusions. 111.68 Section 111.68 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Monetary Penalty in Lieu of Suspension or Revocation § 111.68 Proposed findings and conclusions....

  16. Jumping to the Right Conclusions, Inferences, and Predictions

    ERIC Educational Resources Information Center

    Giannattasio, Jack; Bazler, Judith

    2005-01-01

    Writing meaningful conclusions, drawing accurate inferences, and making relevant predictions are essential skills that many adolescents lack. The differences among conclusions, inferences, and predictions, although subtle, must be recognized to accurately analyze and interpret lab data. During one of the authors' 14 years as a physics and…

  17. On symbolic models for Single-Conclusion Logic of Proofs

    SciTech Connect

    Krupski, Vladimir N

    2011-05-31

    In this paper we define symbolic models for Single-Conclusion Logics of Proofs. We prove the soundness and completeness of these logics with respect to the corresponding classes of symbolic models. We apply the semantic methods developed in this paper to justify the use of terms of single-conclusion logic of proofs as notation for derivations in this logic. Bibliography: 17 titles.

  18. Separation of carbon dioxide and sulfur dioxide gases using room-temperature ionic liquid (hmim)(Tf2N)

    SciTech Connect

    A. Yokozeki; Mark B. Shiflett

    2009-09-15

    To understand capturing and/or enhanced gaseous selectivity of industrial flue gases containing CO{sub 2} and SO{sub 2} using room-temperature ionic liquids, we have developed a ternary equation of state (EOS) model for a CO{sub 2}/SO{sub 2}/1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ((hmim)(Tf2N)) system. The present model is based on a generic RK (Redlich-Kwong) EOS, with empirical binary interaction parameters of each binary system. These interaction parameters have been determined using our measured VLE (vapor-liquid-equilibrium) data for SO{sub 2}/(hmim)(Tf2N) and CO{sub 2}/(hmim)(Tf2N) and literature data for CO{sub 2}/SO{sub 2}. The validity of the present EOS has been checked by conducting ternary VLE experiments for the present system. With this EOS, isothermal ternary phase diagrams and solubility (VLE) behaviors have been calculated for various (T, P, and feed compositions) conditions. For large and equimolar CO{sub 2}/SO{sub 2} mole ratios, the gaseous selectivity is nearly independent of the amount of the ionic liquid addition. However, for small CO{sub 2}/SO{sub 2} mole ratios the addition of the ionic liquid significantly increases the selectivity. The strong absorption of CO{sub 2} and SO{sub 2} in this ionic liquid may be practical for the simultaneous capture of these acid gases. 39 refs., 8 figs., 4 tabs.

  19. Inhibition of Prostate Cancer Bone Metastasis by Synthetic TF Antigen Mimic/Galectin-3 Inhibitor Lactulose-l-Leucine1

    PubMed Central

    Glinskii, Olga V; Sud, Sudha; Mossine, Valeri V; Mawhinney, Thomas P; Anthony, Douglas C; Glinsky, Gennadi V; Pienta, Kenneth J; Glinsky, Vladislav V

    2012-01-01

    Currently incurable, prostate cancer metastasis has a remarkable ability to spread to the skeleton. Previous studies demonstrated that interactions mediated by the cancer-associated Thomsen-Friedenreich glycoantigen (TF-Ag) and the carbohydrate-binding protein galectin-3 play an important role in several rate-limiting steps of cancer metastasis such as metastatic cell adhesion to bone marrow endothelium, homotypic tumor cell aggregation, and clonogenic survival and growth. This study investigated the ability of a synthetic small-molecular-weight nontoxic carbohydrate-based TF-Ag mimic lactulose-l-leucine (Lac-l-Leu) to inhibit these processes in vitro and, ultimately, prostate cancer bone metastasis in vivo. Using an in vivo mouse model, based on intracardiac injection of human PC-3 prostate carcinoma cells stably expressing luciferase, we investigated the ability of Lac-l-Leu to impede the establishment and growth of bone metastasis. Parallel-flow chamber assay, homotypic aggregation assay, modified Boyden chamber assay, and clonogenic growth assay were used to assess the effects of Lac-l-Leu on tumor cell adhesion to the endothelium, homotypic tumor cell aggregation, transendothelial migration, and clonogenic survival and growth, respectively. We report that daily intraperitoneal administration of Lac-l-Leu resulted in a three-fold (P < .05) decrease in metastatic tumor burden compared with the untreated control. Mechanistically, the effect of Lac-l-Leu, which binds and inhibits galectins by mimicking essential structural features of the TF-Ag, was associated with a dose-dependent inhibition of prostate cancer cell adhesion to bone marrow endothelium, homotypic aggregation, transendothelial migration, and clonogenic growth. We conclude that small-molecular-weight carbohydrate-based compounds targeting β-galactoside-mediated interactions could provide valuable means for controlling and preventing metastatic prostate cancer spread to the skeleton. PMID:22355275

  20. Shaping ability of Reciproc and TF Adaptive systems in severely curved canals of rapid microCT-based prototyping molar replicas

    PubMed Central

    ORDINOLA-ZAPATA, Ronald; BRAMANTE, Clovis Monteiro; DUARTE, Marco Antonio Húngaro; CAVENAGO, Bruno Cavalini; JARAMILLO, David; VERSIANI, Marco Aurélio

    2014-01-01

    Objective: To evaluate the shaping ability of Reciproc and Twisted-File Adaptive systems in rapid prototyping replicas. Material and Methods: Two mandibular molars showing S-shaped and 62-degree curvatures in the mesial root were scanned by using a microcomputed tomography (μCT) system. The data were exported in the stereolitograhic format and 20 samples of each molar were printed at 16 µm resolution. The mesial canals of 10 replicas of each specimen were prepared with each system. Transportation was measured by overlapping radiographs taken before and after preparation and resin thickness after instrumentation was measured by μCT. Results: Both systems maintained the original shape of the apical third in both anatomies (P>0.05). Overall, considering the resin thickness in the 62-degree replicas, no statistical difference was found between the systems (P>0.05). In the S-shaped curvature replica, Reciproc significantly decreased the thickness of the resin walls in comparison with TF Adaptive. Conclusions: The evaluated systems were able to maintain the original shape at the apical third of severely curved mesial canals of molar replicas. PMID:24918662

  1. Serum protein polymorphisms (HP, TF-, GC- and PI subtypes) in two mountain communities of Sierra de Gredos (central Spain).

    PubMed

    Moral, P; Vives, S; Fisac, R; Martín, J; Mesa, M S

    1994-12-01

    The genetic variation of four highly polymorphic serum proteins, haptoglobin (HP), transferrin (TF), group-specific component (GC) and alpha-1-antitrypsin (PI) was examined in two representative samples of the autochthonous populations living on either slope of Sierra de Gredos in central Spain. The genetic markers studied do not provide any evidence that the mountain chain has contributed to the maintenance of a genetic differentiation between the two populations. The allele frequency distributions in these Gredos samples are discussed in relation to the variability of these markers in the Iberian Peninsula populations.

  2. Personality and Fibromyalgia Syndrome

    PubMed Central

    Malin, Katrina; Littlejohn, Geoffrey O

    2012-01-01

    Objectives: We aimed to review how personality characteristics contribute to the onset, maintenance or modulation of fibromyalgia. Method: The databases Medline and PsychINFO were examined from 1967 to 2012 to identify studies that investigated associations between fibromyalgia and personality. Search terms included fibromyalgia and personality, trait psychology, characteristics and individual differences. Results: Numerous studies indicate that patients with fibromyalgia experience psychological distress. Various instruments have been used to evaluate distress and related psychological domains, such as anxiety or depression, in fibromyalgia. In many cases, these same instruments have been used to study personality characteristics in fibromyalgia with a subsequent blurring of cause and effect between personality and psychological distress. In addition, the symptoms of fibromyalgia may change pre-illness personality characteristics themselves. These issues make it difficult to identify specific personality characteristics that might influence the fibromyalgia process. Despite this inherent problem with the methodologies used in the studies that make up this literature review, or perhaps because of it, we found no defined personality profile specific to fibromyalgia. However, many patients with fibromyalgia do show personality characteristics that facilitate psychological responses to stressful situations, such as catastrophising or poor coping techniques, and these in turn associate with mechanisms contributing to fibromyalgia. Conclusion: No specific fibromyalgia personality is defined but it is proposed that personality is an important filter that modulates a person’s response to psychological stressors. Certain personalities may facilitate translation of these stressors to physiological responses driving the fibromyalgia mechanism. PMID:23002409

  3. Formation and emission of nitrogen oxide in gas turbine engines: plume effluent characteristics of TF3O-P111+ and TF33-P9 engines. Final technical report, 1 November-17 December 1993

    SciTech Connect

    Dill, J.W.; Sowa, W.A.; Samuelsen, G.S.

    1996-06-30

    Phase I of this project focused on the creation of a spatial emissions map of the plume effluent in the exhaust stream directly behind the engine in a jet engine test cell (JETC). Both afterburning TF30-P111+ and non-after-burning TF33-P9 engines were tested. Measurements were taken in conjunction with actual engine tests for validity of the data. Temperature, oxides of nitrogen (NOx), carbon monoxide (CO) concentration, and velocity were among the characteristics measured radially and axially in the plume for each engine type. The main focus of this study was on NOx, consisting of nitric oxide (NO) and nitrogen dioxide (NO2). Measurements in the P111+ plume reveal levels of NOx above 300 ppm along the centerline of the effluent. A dip in the NOx emissions at afterburner shows signs of a reburning and/or dilution effect by the atmospheric combustion in the effluent. Significant amounts of NO2 are present in the effluent over the entire power range. Temperatures at military power reach 1100 deg F along the centerline, and CO values are below 80 ppm. Carbon monoxide concentrations decrease from idle to military power (full power, no afterburner), then rise sharply in afterburner. The CO peaks shift outward from centerline as do the temperatures due to the radial geometry of the afterburner combustion (over 10 percent CO at 2850 deg F).

  4. A novel alignment-free method for detection of lateral genetic transfer based on TF-IDF

    PubMed Central

    Cong, Yingnan; Chan, Yao-ban; Ragan, Mark A.

    2016-01-01

    Lateral genetic transfer (LGT) plays an important role in the evolution of microbes. Existing computational methods for detecting genomic regions of putative lateral origin scale poorly to large data. Here, we propose a novel method based on TF-IDF (Term Frequency-Inverse Document Frequency) statistics to detect not only regions of lateral origin, but also their origin and direction of transfer, in sets of hierarchically structured nucleotide or protein sequences. This approach is based on the frequency distributions of k-mers in the sequences. If a set of contiguous k-mers appears sufficiently more frequently in another phyletic group than in its own, we infer that they have been transferred from the first group to the second. We performed rigorous tests of TF-IDF using simulated and empirical datasets. With the simulated data, we tested our method under different parameter settings for sequence length, substitution rate between and within groups and post-LGT, deletion rate, length of transferred region and k size, and found that we can detect LGT events with high precision and recall. Our method performs better than an established method, ALFY, which has high recall but low precision. Our method is efficient, with runtime increasing approximately linearly with sequence length. PMID:27453035

  5. Nests with numerous SOX10 and MiTF-positive cells in lichenoid inflammation: pseudomelanocytic nests or authentic melanocytic proliferation?

    PubMed

    Silva, Claudine Yap; Goldberg, Lynne J; Mahalingam, Meera; Bhawan, Jag; Wolpowitz, Deon

    2011-10-01

    Pseudomelanocytic nests in the setting of lichenoid inflammation can mimic atypical melanocytic proliferations. Both melanocytic and cytokeratin immunohistochemical stains may be utilized to differentiate these entities. Unlike true melanocytic nests, pseudomelanocytic nests contain Melanoma Antigen Recognized by T-cells 1 (MART-1)/ Melan-A-positive cells and cells positive for pan-cytokeratins, CD3 and/or CD68. Recently, rare (1-2 cells/nest) microphthalmia- associated transcription factor (MiTF)-positive cells were also reported in pseudomelanocytic nests. We present a 48-year-old man with a 2 × 3 cm violaceous to hyperpigmented, non-blanching, polygonal patch on the neck. Histopathology showed focal epidermal atrophy, irregularly distributed junctional nests and a lichenoid infiltrate with colloid bodies. Immunoperoxidase studies revealed occasional pan-cytokeratin and MART-1/Melan-A-positive staining in nests as well as focal S-100 protein-positive cells. Importantly, the majority of nests showed numerous cells positive for MiTF and SOX10 (>2 cells/nest and some the majority of cells). This combined staining pattern confounds the above-described immunohistochemical distinction between pseudo and true melanocytic nests. Clinically felt to represent unilateral lichen planus pigmentosus/erythema dyschromicum perstans and not malignant melanoma in situ, this lesion highlights the importance of clinicopathologic correlation and suggests either a new melanocytic entity or a novel pattern of benign melanocytic reorganization in a subset of lichenoid dermatitides.

  6. Conclusiveness of natural languages and recognition of images

    SciTech Connect

    Wojcik, Z.M.

    1983-01-01

    The conclusiveness is investigated using recognition processes and one-one correspondence between expressions of a natural language and graphs representing events. The graphs, as conceived in psycholinguistics, are obtained as a result of perception processes. It is possible to generate and process the graphs automatically, using computers and then to convert the resulting graphs into expressions of a natural language. Correctness and conclusiveness of the graphs and sentences are investigated using the fundamental condition for events representation processes. Some consequences of the conclusiveness are discussed, e.g. undecidability of arithmetic, human brain assymetry, correctness of statistical calculations and operations research. It is suggested that the group theory should be imposed on mathematical models of any real system. Proof of the fundamental condition is also presented. 14 references.

  7. General conclusions regarding the planetary-solar-terrestrial interaction

    NASA Astrophysics Data System (ADS)

    Mörner, N.-A.; Tattersall, R.; Solheim, J.-E.; Charvatova, I.; Scafetta, N.; Jelbring, H.; Wilson, I. R.; Salvador, R.; Willson, R. C.; Hejda, P.; Soon, W.; Velasco Herrera, V. M.; Humlum, O.; Archibald, D.; Yndestad, H.; Easterbrook, D.; Casey, J.; Gregori, G.; Henriksson, G.

    2013-12-01

    In a collection of research papers devoted to the problem of solar variability and its origin in planetary beat, it is demonstrated that the forcing function originates from gravitational and inertial effects on the Sun from the planets and their satellites. This conclusion is shared by nineteen co-authors.

  8. 40 CFR 35.6820 - Conclusion of the SSC.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Requirements for Administering A Superfund State Contract (ssc) § 35.6820 Conclusion of the SSC... all future operation and maintenance as required by CERCLA section 104(c) and addressed in 40 CFR...

  9. 40 CFR 35.6820 - Conclusion of the SSC.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Requirements for Administering A Superfund State Contract (ssc) § 35.6820 Conclusion of the SSC... all future operation and maintenance as required by CERCLA section 104(c) and addressed in 40 CFR...

  10. 40 CFR 35.6820 - Conclusion of the SSC.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Requirements for Administering A Superfund State Contract (ssc) § 35.6820 Conclusion of the SSC... all future operation and maintenance as required by CERCLA section 104(c) and addressed in 40 CFR...

  11. 40 CFR 35.6820 - Conclusion of the SSC.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Requirements for Administering A Superfund State Contract (ssc) § 35.6820 Conclusion of the SSC... all future operation and maintenance as required by CERCLA section 104(c) and addressed in 40 CFR...

  12. 40 CFR 35.6820 - Conclusion of the SSC.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund Response Actions Requirements for Administering A Superfund State Contract (ssc) § 35.6820 Conclusion of the SSC... all future operation and maintenance as required by CERCLA section 104(c) and addressed in 40 CFR...

  13. Area V Vocational Education Planning Conclusions and Recommendations: Third Report.

    ERIC Educational Resources Information Center

    Area 5 Vocational Planning Committee, Pleasant Hill, CA.

    Conclusions and recommendations regarding the development of an Area Master Plan to provide maximum coordination between vocational, technical, adult, and continuing education agencies within Alameda and Contra Costa Counties, California, are presented. The Area Five Planning Committee, which developed the Master Plan, based its evaluation and…

  14. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  15. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  16. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  17. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  18. 22 CFR 18.18 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Proposed findings and conclusions. 18.18 Section 18.18 Foreign Relations DEPARTMENT OF STATE PERSONNEL REGULATIONS CONCERNING POST EMPLOYMENT CONFLICT OF INTEREST Administrative Enforcement Proceedings § 18.18 Proposed findings and...

  19. When Proofs Reflect More on Assumptions than Conclusions

    ERIC Educational Resources Information Center

    Dawkins, Paul Christian

    2014-01-01

    This paper demonstrates how questions of "provability" can help students engaged in reinvention of mathematical theory to understand the axiomatic game. While proof demonstrates how conclusions follow from assumptions, "provability" characterizes the dual relation that assumptions are "justified" when they afford…

  20. 49 CFR 511.46 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Proposed findings, conclusions, and order. 511.46 Section 511.46 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ADJUDICATIVE PROCEDURES Hearings §...

  1. Overview of human health in the Arctic: conclusions and recommendations

    PubMed Central

    Donaldson, Shawn; Adlard, Bryan; Odland, Jon Øyvind

    2016-01-01

    This article is intended to provide an overview of the key conclusions, knowledge gaps and key recommendations based on the recent 2015 Arctic human health assessment under the Arctic Monitoring and Assessment Program. This assessment was based primarily on data from human health monitoring and research studies and peer-reviewed literature published since the last assessment in 2009. PMID:27974138

  2. 10 CFR 2.712 - Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Proposed findings and conclusions. 2.712 Section 2.712 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF... proceeding may, or if directed by the presiding officer shall, file proposed findings of fact and...

  3. 20 CFR 901.48 - Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Proposed findings and conclusions. 901.48 Section 901.48 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 Suspension...

  4. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    ERIC Educational Resources Information Center

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  5. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Proposed findings, conclusions, and order. 672.19 Section 672.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... law, and a proposed order, together with supporting briefs, within twenty (20) days after the...

  6. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Proposed findings, conclusions, and order. 672.19 Section 672.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... law, and a proposed order, together with supporting briefs, within twenty (20) days after the...

  7. 45 CFR 672.19 - Proposed findings, conclusions, and order.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Proposed findings, conclusions, and order. 672.19 Section 672.19 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... law, and a proposed order, together with supporting briefs, within twenty (20) days after the...

  8. Evaluation of inter-laminar shear strength of GFRP composed of bonded glass/polyimide tapes and cyanate-ester/epoxy blended resin for ITER TF coils

    SciTech Connect

    Hemmi, T.; Matsui, K.; Koizumi, N.; Nishimura, A.; Nishijima, S.; Shikama, T.

    2014-01-27

    The insulation system of the ITER TF coils consists of multi-layer glass/polyimide tapes impregnated a cyanate-ester/epoxy resin. The ITER TF coils are required to withstand an irradiation of 10 MGy from gamma-ray and neutrons since the ITER TF coils is exposed by fast neutron (>0.1 MeV) of 10{sup 22} n/m{sup 2} during the ITER operation. Cyanate-ester/epoxy blended resins and bonded glass/polyimide tapes are developed as insulation materials to realize the required radiation-hardness for the insulation of the ITER TF coils. To evaluate the radiation-hardness of the developed insulation materials, the inter-laminar shear strength (ILSS) of glass-fiber reinforced plastics (GFRP) fabricated using developed insulation materials is measured as one of most important mechanical properties before/after the irradiation in a fission reactor of JRR-3M. As a result, it is demonstrated that the GFRPs using the developed insulation materials have a sufficient performance to apply for the ITER TF coil insulation.

  9. Evaluation of inter-laminar shear strength of GFRP composed of bonded glass/polyimide tapes and cyanate-ester/epoxy blended resin for ITER TF coils

    NASA Astrophysics Data System (ADS)

    Hemmi, T.; Nishimura, A.; Matsui, K.; Koizumi, N.; Nishijima, S.; Shikama, T.

    2014-01-01

    The insulation system of the ITER TF coils consists of multi-layer glass/polyimide tapes impregnated a cyanate-ester/epoxy resin. The ITER TF coils are required to withstand an irradiation of 10 MGy from gamma-ray and neutrons since the ITER TF coils is exposed by fast neutron (>0.1 MeV) of 1022 n/m2 during the ITER operation. Cyanate-ester/epoxy blended resins and bonded glass/polyimide tapes are developed as insulation materials to realize the required radiation-hardness for the insulation of the ITER TF coils. To evaluate the radiation-hardness of the developed insulation materials, the inter-laminar shear strength (ILSS) of glass-fiber reinforced plastics (GFRP) fabricated using developed insulation materials is measured as one of most important mechanical properties before/after the irradiation in a fission reactor of JRR-3M. As a result, it is demonstrated that the GFRPs using the developed insulation materials have a sufficient performance to apply for the ITER TF coil insulation.

  10. Absence of social conditioned place preference in BTBR T+tf/J mice: relevance for social motivation testing in rodent models of autism.

    PubMed

    Pearson, Brandon L; Bettis, Jaclyn K; Meyza, Ksenia Z; Yamamoto, Lace Y; Blanchard, D Caroline; Blanchard, Robert J

    2012-07-15

    A major goal of translation research in autism is to characterize the physiological and psychological processes underlying behavioral abnormalities. Since autism reflects impairments in social motivation, we modified the mouse three-chamber social approach apparatus for use as a social conditioned place preference arena. We paired one of two unique contexts with social interactions in juvenile mice for five or ten conditioning sessions in BTBR T+tf/J mice and a control strain with normal approach behaviors (C57BL/6J) since the BTBR T+tf/J inbred mouse strain displays a variety of behavioral alterations analogous to symptoms of autism spectrum disorders. While C57BL/6J mice formed a conditioned place preference to the context associated with social interactions, particularly those receiving ten days of conditioning, BTBR T+tf/J mice did not. Neither absence of social proximity nor avoidance due to high rates of autogrooming appeared to underlie the impaired positive incentive value of the unconditioned social stimulus in the BTBR T+tf/J strain. These data contribute to a growing body of evidence suggesting that the BTBR T+tf/J strain shows impairments in all diagnostic domains of autism including social motivation. Additionally, social conditioning testing might provide an important social motivation measure in other rodent models of neuropsychiatric disorders characterized by social abnormalities.

  11. Jumping to conclusions in untreated patients with Parkinson's disease

    PubMed Central

    de Rezende Costa, Flavio Henrique; Averbeck, Bruno; O'Sullivan, Sean S.; Vincent, Maurice Borges; Rosso, Ana Lucia; Lees, Andrew J.; Djamshidian, Atbin

    2016-01-01

    Background Jumping to conclusions due to impulsivity has been shown to be a sensitive marker for dopamine dysregulation and addictive behaviour patterns in treated patients with Parkinson's disease (PD). It is unknown whether drug naïve PD patients, who have never received dopaminergic therapy also have deficits in information sampling. Methods Twenty five de novo PD patients and twenty matched healthy controls were recruited and tested on the beads task, which is a validated information sampling task to assess reflection impulsivity and a temporal discounting questionnaire. Results Patients gathered significantly less information and made more irrational choices than matched controls. There was, however, no group difference on the temporal discounting questionnaire. Conclusions Poor information sampling and irrational decision making may be an inherent component of the neuropsychological deficit in Parkinson's disease. These findings suggest that underlying impulsivity detected by a metric task is common in de novo PD. PMID:26956927

  12. [Problems of occupational fitness conclusion on periodic medical examination].

    PubMed

    Alekseev, V B; Vlasova, E M; Nosov, A E; Ponomareva, T A; Kostarev, V G

    2014-01-01

    Additional examination in Occupational Pathology Center are economic loss both for employer and employee, as the employee receives payment for those days when in the examination. Analysis of over 600 cases of occupational fitness examination in Occupational Pathology Center according to referrals given by medical institutions providing periodic medical examination shows that in most cases the conclusion was possible during periodic medical examination. Difficulties in conclusion on workers' fitness for occupation during periodic medical examination, according to our viewpoint, result not from limited diagnostic facilities for adequate examination and unfitness disclosure, but from lack of information in primary medical documentation and inadequacy of occupational factor and work characteristics presented by employer to actual working conditions.

  13. PLGA-PLL-PEG-Tf-based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway

    PubMed Central

    Bao, Wen; Liu, Ran; Wang, Yonglu; Wang, Fei; Xia, Guohua; Zhang, Haijun; Li, Xueming; Yin, Haixiang; Chen, Baoan

    2015-01-01

    Chemotherapy offers a systemic cancer treatment; however, it is limited in clinical administration due to its serious side effects. In cancer medicine, the use of nanoparticles (NPs) drug delivery system (DDS) can sustainedly release anticancer drug at the specific site and reduce the incidence of toxicity in normal tissues. In the present study, we aimed to evaluate the benefit of a novel chemotherapeutic DDS and its underlying mechanisms. Daunorubicin (DNR) was loaded into poly (lactic-co-glycolic acid) (PLGA)-poly-l-lysine (PLL)-polyethylene glycol (PEG)-transferrin (Tf) NPs to construct DNR-PLGA-PLL-PEG-Tf-NPs (DNR-loaded NPs) as a DDS. After incubating with PLGA-PLL-PEG-Tf-NPs, DNR, and DNR-loaded NPs, the leukemia K562 cells were collected and the intracellular concentration of DNR was detected by flow cytometry, respectively. Furthermore, the effect of drugs on the growth of tumors in K562 xenografts was observed and the relevant toxicity of therapeutic drugs on organs was investigated in vivo. Meanwhile, cell apoptosis in the excised xenografts was measured by transferase-mediated dUTP nick-end labeling assay, and the expression of apoptosis-related proteins, including Bcl-2, Bax, Caspase-9, Caspase-3, and cleaved-PARP, was determined by Western blotting analysis. Results showed that DNR-loaded NPs increased intracellular concentration of DNR in K562 cells in vitro and induced a remarkable improvement in anticancer activity in the xenografts in vivo. The expression of Bcl-2 protein was downregulated and that of Bax, Caspase-9, Caspase-3, and cleaved-PARP proteins were obviously upregulated in the DNR-loaded NPs group than that in other ones. Interestingly, pathological assessment showed no apparent damage to the main organs. In summary, the results obtained from this study showed that the novel NPs DDS could improve the efficacy of DNR in the treatment of leukemia and induce apoptosis via intrinsic pathway. Thus, it can be inferred that the new drug

  14. Statistical Conclusion Validity: Some Common Threats and Simple Remedies

    PubMed Central

    García-Pérez, Miguel A.

    2012-01-01

    The ultimate goal of research is to produce dependable knowledge or to provide the evidence that may guide practical decisions. Statistical conclusion validity (SCV) holds when the conclusions of a research study are founded on an adequate analysis of the data, generally meaning that adequate statistical methods are used whose small-sample behavior is accurate, besides being logically capable of providing an answer to the research question. Compared to the three other traditional aspects of research validity (external validity, internal validity, and construct validity), interest in SCV has recently grown on evidence that inadequate data analyses are sometimes carried out which yield conclusions that a proper analysis of the data would not have supported. This paper discusses evidence of three common threats to SCV that arise from widespread recommendations or practices in data analysis, namely, the use of repeated testing and optional stopping without control of Type-I error rates, the recommendation to check the assumptions of statistical tests, and the use of regression whenever a bivariate relation or the equivalence between two variables is studied. For each of these threats, examples are presented and alternative practices that safeguard SCV are discussed. Educational and editorial changes that may improve the SCV of published research are also discussed. PMID:22952465

  15. Viscoelasticity and Ultrastructure in Coagulation and Inflammation: Two Diverse Techniques, One Conclusion.

    PubMed

    Swanepoel, Albe C; Nielsen, Vance G; Pretorius, Etheresia

    2015-08-01

    The process of blood clotting has been studied for centuries. A synopsis of current knowledge pertaining to haemostasis and the blood components, including platelets and fibrin networks which are closely involved in coagulation, are discussed. Special emphasis is placed on tissue factor (TF), calcium and thrombin since these components have been implicated in both the coagulation process and inflammation. Analysis of platelets and fibrin morphology indicate that calcium, tissue factor and thrombin at concentrations used during viscoelastic analysis (with thromboelastography or TEG) bring about alterations in platelet and fibrin network ultrastructure, which is similar to that seen in inflammation. Scanning electron microscopy indicated that, when investigating platelet structure in disease, addition of TF, calcium or thrombin will mask disease-induced alterations associated with platelet activation. Therefore, washed platelets without any additives is preferred for morphological analysis. Furthermore, morphological and viscoelastic analysis confirmed that thrombin activation is the preferred method of fibrin activation when investigating fibrin network ultrastructure.

  16. Identification of multiple conformers of the ionic liquid [emim][tf2n] in the gas phase using IR/UV action spectroscopy.

    PubMed

    Booth, Ryan S; Annesley, Christopher J; Young, Justin W; Vogelhuber, Kristen M; Boatz, Jerry A; Stearns, Jaime A

    2016-06-22

    In this study we investigate the effect of deuteration and molecular beam temperature on the hydrogen bond in the ionic liquid [emim][tf2n]. Using IR/UV double resonance spectroscopy, we probe the microscopic structure of the [emim][tf2n] ion pair and its mono-deuterated, [emim-d1][tf2n], analog. Comparisons of the infrared absorption frequencies between these two species show that there are multiple conformers of the ion pair present in the gas phase and trapped through the molecular beam cooling process. Furthermore, each conformer has a characteristic red shift in the frequency of its C2-H group that reveals the variation in strength of a hydrogen bond between the cation and anion.

  17. European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

    PubMed Central

    Poller, L; Keown, M; Chauhan, N; van den Besselaar, A M H P; Tripodi, A; Shiach, C; Jespersen, J

    2005-01-01

    A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised. PMID:15917425

  18. Conclusions from the Image Analysis of the VSOP Survey

    NASA Astrophysics Data System (ADS)

    Dodson, R.; Fomalont, E.; Wiik, K.

    2009-08-01

    In February 1997, the Japanese radio astronomy satellite HALCA was launched to provide the space-bourne element for the VLBI Space Observatory Programme (VSOP) mission. A significant fraction of the mission time was to be dedicated to the VSOP Survey of bright compact Active Galactic Nuclei (AGN) at 5 GHz, which was lead by ISAS. The VSOP Survey Sources are an unbiased dataset of 294 targets, of which 82% were successfully observed. These are now undergoing statistical analysis to tease out the characteristics of typical AGN sources. We present here the summary of the imaging and conclusions we have reached.

  19. Path to Zero: Ultra-Efficient Architecture on the NREL Campus: S&TF and Master Planning (Presentation)

    SciTech Connect

    Carlisle, N.

    2012-05-01

    Describe the aspects of NREL's S and TF and Campus Master Planning in terms of how they have influenced ultra-efficient architecture on NREL's campus. Energy goals for the NREL campus are: (1) Understand how buildings uses energy, implement the cost-effective energy and water efficiency retrofits; (2) Use principals of energy efficiency and low energy design to reduce energy demand in all new construction; (3) Operate central plants efficiently; (4) Alternative transportation; (5) Use combined heat and power systems; (6) Use on-site renewables for demonstration and where it is cost-effective; and (7) Buy green power (over the next 25 years) so that 100% of our power will be from renewable sources.

  20. a Study on Design Optimization of Conical Bolt in the TF Coil Structure of the Kstar Tokamak

    NASA Astrophysics Data System (ADS)

    Kwon, Young-Doo; Lee, Dae-Suep

    The goals of the KSTAR project are to develop a steady-state-capable advanced superconducting Tokamak and establish a scientific and technological basis for a Korean nuclear fusion power station. The KSTAR Tokamak comprises a magnet system, vacuum vessel, and cryostat, thereby facilitating vacuum conditions for plasma gas at high temperatures, along with low-temperature helium gas for cooling. The TF coil structure, a part of the magnet system, is constructed and jointed with 16 pieces at 22.5-degree intervals using a conical bolt and shear key. The main function of the conical bolt in the inner and outer inter-coil structures is to resist the in-plane and out-of-plane forces and increase the toroidal and intercoil shear stiffness. Therefore, the conical bolt must be dimensionally optimized to reduce the stresses at each connecting part. Accordingly, shape optimization of the conical bolt was carried out using SZGA, and the stresses were analyzed by ANSYS.

  1. Workshop observations, conclusions, and recommendations for moving forward

    SciTech Connect

    1995-12-31

    Bangkok currently has enormous numbers of motorised vehicles. The number of motor vehicles registered in Bangkok in 1993 was about 2.6 million of which over 1 million were cars and around 1.1 million were motorcycles. The vehicle population is noticeably increasing at about 12% over the previous year, despite the traffic congestion which is nearly at gridlock. Overall average traffic speed in the Bangkok metropolitan area is around 10 km/h. However, during peak hours on some main roads in the central business area, the crawl rate is at 1-2 km/h, or only half walking pace. There are, however, several circumstances to be addressed before Bangkok can begin to overcome its air quality and congestion problems. The first is that many of the city`s transport planners that design transport projects, and the policymakers with investment authority appear to be caught in the same conventional transport planning paradigm as many other industrializing and industrialized countries. That paradigm, pioneered in the United States and exported to much of the world, defines the problems as a shortage of road space to meet demand for, private, vehicular mobility. The investment focus is almost exclusively on the construction of large road-based infrastructure to machines instead of people, while de-emphasizing other forms of transport such as rail, water, and non-motorized transport - even if they are a less expensive investment that can meet demand. The predominance of this paradigm results in a persistent myth held by many of Bangkok`s policymakers, transport and urban planners, financiers, and citizens. The myth is that the city does not have enough kilometers of roadways per person, and should focus on road and highway investment in order to solve their air quality and congestion problems.

  2. Dielectric relaxation and ultrafast transient absorption spectroscopy of [C6mim]+[Tf2N]−/acetonitrile mixtures.

    PubMed

    Lohse, Peter W; Bartels, Nils; Stoppa, Alexander; Buchner, Richard; Lenzer, Thomas; Oum, Kawon

    2012-03-14

    Mixtures of the ionic liquid (IL) [C(6)mim](+)[Tf(2)N](-) and acetonitrile have been investigated by a combination of dielectric relaxation spectroscopy (DRS) and ultrafast transient absorption techniques using the molecular probe 12'-apo-β-carotenoic-12'-acid (12'CA). Steady-state absorption spectra of the 12'CA molecule have also been recorded. The position of the probe's S(0)→ S(2) absorption maximum correlates linearly with the polarizability of the mixture, suggesting that the bulk composition is a good approximation to the local composition. The lifetime τ(1) of the S(1)/ICT state of 12'CA varies rather smoothly with composition between the value for pure acetonitrile (42 ps) and neat [C(6)mim](+)[Tf(2)N](-) (94 ps). At low IL contents there appears to be an influence of discrete ion pairs. Employing static dielectric constants from the DRS experiments, one finds that the lifetime of the probe in the IL mixtures is shorter than that in pure organic solvents with the same polarity parameter. This suggests an increased stabilization of the S(1)/ICT state in IL-containing mixtures, most likely due to IL-specific Coulombic interactions between the cation and the negative end of the probe's dipole. An ultrafast solvation component is observed which is ca. 0.5 ps in pure acetonitrile, and approaches the value for the pure IL (2.0 ps) already around x(IL) = 0.3. This is interpreted in terms of an efficient perturbation of the cooperative solvation response of acetonitrile by the presence of small amounts of IL and possibly also the viscosity increase when adding IL. This view is also supported by the increase of the average longitudinal relaxation time of acetonitrile upon addition of small IL amounts extracted from the DRS experiments.

  3. The Evidence and Conclusion Ontology (ECO): Supporting GO Annotations.

    PubMed

    Chibucos, Marcus C; Siegele, Deborah A; Hu, James C; Giglio, Michelle

    2017-01-01

    The Evidence and Conclusion Ontology (ECO) is a community resource for describing the various types of evidence that are generated during the course of a scientific study and which are typically used to support assertions made by researchers. ECO describes multiple evidence types, including evidence resulting from experimental (i.e., wet lab) techniques, evidence arising from computational methods, statements made by authors (whether or not supported by evidence), and inferences drawn by researchers curating the literature. In addition to summarizing the evidence that supports a particular assertion, ECO also offers a means to document whether a computer or a human performed the process of making the annotation. Incorporating ECO into an annotation system makes it possible to leverage the structure of the ontology such that associated data can be grouped hierarchically, users can select data associated with particular evidence types, and quality control pipelines can be optimized. Today, over 30 resources, including the Gene Ontology, use the Evidence and Conclusion Ontology to represent both evidence and how annotations are made.

  4. IR and electrochemical synthesis and characterization of thin films of PEDOT grown on platinum single crystal electrodes in [EMMIM]Tf2N ionic liquid.

    PubMed

    Sandoval, Andrea P; Suárez-Herrera, Marco F; Feliu, Juan M

    2015-01-01

    Thin films of PEDOT synthesized on platinum single electrodes in contact with the ionic liquid 1-ethyl-2,3-dimethylimidazolium triflimide ([EMMIM]Tf2N) were studied by cyclic voltammetry, chronoamperometry, infrared spectroscopy and atomic force microscopy. It was found that the polymer grows faster on Pt(111) than on Pt(110) or Pt(100) and that the redox reactions associated with the PEDOT p-doping process are much more reversible in [EMMIM]Tf2N than in acetonitrile. Finally, the ion exchange and charge carriers' formation during the p-doping reaction of PEDOT were studied using in situ FTIR spectroscopy.

  5. IR and electrochemical synthesis and characterization of thin films of PEDOT grown on platinum single crystal electrodes in [EMMIM]Tf2N ionic liquid

    PubMed Central

    Sandoval, Andrea P; Suárez-Herrera, Marco F

    2015-01-01

    Summary Thin films of PEDOT synthesized on platinum single electrodes in contact with the ionic liquid 1-ethyl-2,3-dimethylimidazolium triflimide ([EMMIM]Tf2N) were studied by cyclic voltammetry, chronoamperometry, infrared spectroscopy and atomic force microscopy. It was found that the polymer grows faster on Pt(111) than on Pt(110) or Pt(100) and that the redox reactions associated with the PEDOT p-doping process are much more reversible in [EMMIM]Tf2N than in acetonitrile. Finally, the ion exchange and charge carriers’ formation during the p-doping reaction of PEDOT were studied using in situ FTIR spectroscopy. PMID:25815089

  6. Personality disorders

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/000939.htm Personality disorders To use the sharing features on this page, please enable JavaScript. Personality disorders are a group of mental conditions in ...

  7. Personality Disorders

    MedlinePlus

    Personality disorders are a group of mental illnesses. They involve long-term patterns of thoughts and behaviors ... serious problems with relationships and work. People with personality disorders have trouble dealing with everyday stresses and ...

  8. Conclusive quantum steering with superconducting transition-edge sensors

    NASA Astrophysics Data System (ADS)

    Smith, Devin H.; Gillett, Geoff; de Almeida, Marcelo P.; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gerrits, Thomas; Wiseman, Howard M.; Nam, Sae Woo; White, Andrew G.

    2012-01-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date, all experimental tests with single-photon states have relied on post selection, allowing untrusted devices to cheat by hiding unfavourable events in losses. Here we close this 'detection loophole' by combining a highly efficient source of entangled photon pairs with superconducting transition-edge sensors. We achieve an unprecedented ~62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 s.d.s. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  9. Conclusive quantum steering with superconducting transition edge sensors

    NASA Astrophysics Data System (ADS)

    de Almeida, Marcelo P.; Smith, Devin H.; Gillett, Geo; Branciard, Cyril; Fedrizzi, Alessandro; Weinhold, Till J.; Lita, Adriana; Calkins, Brice; Gertis, Thomas; Nam, Sae Woo; White, Andrew G.

    2012-02-01

    Quantum steering allows two parties to verify shared entanglement even if one measurement device is untrusted. A conclusive demonstration of steering through the violation of a steering inequality is of considerable fundamental interest and opens up applications in quantum communication. To date all experimental tests with single photon states have relied on post-selection, allowing untrusted devices to cheat by hiding unfavorable events in losses. Here we close this ``detection loophole'' by combining a highly efficient source of entangled photon pairs with superconducting transition edge sensors. We achieve an unprecedented ˜62% conditional detection efficiency of entangled photons and violate a steering inequality with the minimal number of measurement settings by 48 standard deviations. Our results provide a clear path to practical applications of steering and to a photonic loophole-free Bell test.

  10. The no conclusion intervention for couples in conflict.

    PubMed

    Migerode, Lieven

    2014-07-01

    Dealing with difference is central to all couple therapy. This article presents an intervention designed to assist couples in handling conflict. Central to this approach is the acceptance that most conflicts cannot be solved. Couples are in need of a different understanding of couples conflict. This understanding is found in the analysis of love in context and in relational dialectics. Couples are guided through different steps: deciding on the valence of the issue as individuals, helping them decide which differences can be resolved and which issues demand new ways of living with the inevitable, and the introduction in the suggested no conclusion dialogue. This article briefly describes the five day intensive couple therapy program, in which the no intervention is embedded. The theoretical foundation of the intervention, followed by the step by step description of the intervention forms the major part of the article. A case vignette illustrates this approach.

  11. Equipment qualification risk scoping analyses: Results and conclusions

    SciTech Connect

    Bustard, L.D.; Kolaczkowski, A.M.

    1989-01-01

    Probabilistic risk assessment (PRA) techniques and insights have been employed during an investigation entitled the Equipment Qualification (EQ)-Risk Scoping Study to assess the risk significance of equipment qualification issues. This approach for evaluating EQ issues suggests that some issues are not risk significant while some have a significant potential to increase risk. For example, EQ issues associated with long term accident equipment operability are not risk significant. Alternatively, there are selected system operations that require equipment not qualified for important accident environments. Though the study demonstrated that PRA does provide insights that modify perceptions regarding the importance of various EQ issues, it should be noted that PRA methods currently cannot define the risk significance for some EQ issues. Additional discussion regarding the study's results and conclusions is provided. 6 refs.

  12. Differences between evolution of Titan's and Earth's rivers - further conclusions

    NASA Astrophysics Data System (ADS)

    Misiura, Katarzyna; Czechowski, Leszek

    2014-05-01

    Titan is the only celestial body, beside the Earth, where liquid is present on the surface. Liquid forms a number of lakes and rivers. In our research we use numerical model of the river to determine differences of evolution of rivers on the Earth and on Titan. We have found that transport of sediments on Titan is more effective than on Earth for the same river geometry and discharge. We have found also the theoretical explanations for this conclusion. 2.Introduction Titan is a very special body in the Solar System. It is the only moon that has dense atmosphere and flowing liquid on its surface. The Cassini-Huygens mission has found on Titan meandering rivers, and indicated processes of erosion, transport of solid material and its sedimentation. This paper is aimed to investigate the similarity and differences between these processes on Titan and the Earth. 3. Basic equations of our model The dynamical analysis of the considered rivers is performed using the package CCHE modified for the specific conditions on Titan. The package is based on the Navier-Stokes equations for depth-integrated two dimensional, turbulent flow and three dimensional convection-diffusion equation of sediment transport. 4. Parameters of the model We considered our model for a few kinds of liquid found on Titan. The liquid that falls as a rain (75% methane, 25% nitrogen) has different properties than the fluid forming lakes (74% ethane, 10% methane, 7% propane, 8.5% butane, 0.5% nitrogen). Other parameters of our model are: inflow discharge, outflow level, grain size of sediments etc. For every calculation performed for Titan's river similar calculations are performed for terrestrial ones. 5. Results and Conclusions The results of our simulation show the differences in behaviour of the flow and of sedimentation on Titan and on the Earth. Our preliminary results indicate that transport of material by Titan's rivers is more efficient than by terrestrial rivers of the same geometry parameters

  13. The sandflat habitat: Scaling from experiments to conclusions

    USGS Publications Warehouse

    Thrush, S.F.; Pridmore, R.D.; Bell, R.G.; Cummings, V.J.; Dayton, P.K.; Ford, R.; Grant, J.; Green, M.O.; Hewitt, J.E.; Hines, A.H.; Hume, T.M.; Lawrie, S.M.; Legendre, P.; McArdle, B.H.; Morrisey, D.; Schneider, Davod C.; Turner, S.J.; Walters, R.A.; Whitlatch, R.B.; Wilkinson, M.R.

    1997-01-01

    Ecological systems are characterised by spatial and temporal variations in the density of organisms and resources, and in the intensity of processes which affect them (e.g. Watt, 1947, Dayton, 1971, Addicot et al., 1987, Kolasa and Pickett, 1991 and Giller et al., 1994). This heterogeneity represents both a difficulty for field study design and statistical testing, and a challenge to describe the spatial structuring of populations, communities and ecosystems (Legendre, 1993). Patterns in ecological and environmental variables are fundamental to developing hypotheses and in designing subsequent field studies, because they determine the spatial and temporal scales of study. Spatial and/or temporal patterns also provide useful stepping stones for addressing issues of scale. Patterns apparent at one scale can collapse to noise when viewed from other scales, indicating that patterns, processes and our perceptions vary in a scale-dependent manner. Perhaps the most important but rarely discussed issue is the question of how to scale-up from small-scale surveys and experiments to conclusions relevant at larger spatial and temporal scales.

  14. Collaborative Automation Reliably Remediating Erroneous Conclusion Threats (CARRECT)

    PubMed Central

    Lansey, Jonathan C.; Picciano, Paul; Yohai, Ian; Grant, Fred; Gern, Robert

    2013-01-01

    Objective The objective of the CARRECT software is to make cutting edge statistical methods for reducing bias in epidemiological studies easy to use and useful for both novice and expert users. Introduction Analyses produced by epidemiologists and public health practitioners are susceptible to bias from a number of sources including missing data, confounding variables, and statistical model selection. It often requires a great deal of expertise to understand and apply the multitude of tests, corrections, and selection rules, and these tasks can be time-consuming and burdensome. To address this challenge, Aptima began development of CARRECT, the Collaborative Automation Reliably Remediating Erroneous Conclusion Threats system. When complete, CARRECT will provide an expert system that can be embedded in an analyst’s workflow. CARRECT will support statistical bias reduction and improved analyses and decision making by engaging the user in a collaborative process in which the technology is transparent to the analyst. Methods Older approaches to imputing missing data, including mean imputation and single imputation regression methods, have steadily given way to a class of methods known as “multiple imputation” (hereafter “MI”; Rubin 1987). Rather than making the restrictive assumption that the data are missing completely at random (MCAR), MI typically assumes the data are missing at random (MAR). There are two key innovations behind MI. First, the observed values can be useful in predicting the missing cells, and thus specifying a joint distribution of the data is the first step in implementing the models. Second, single imputation methods will likely fail not only because of the inherent uncertainty in the missing values but also because of the estimation uncertainty associated with generating the parameters in the imputation procedure itself. By contrast, drawing the missing values multiple times, thereby generating m complete datasets along with the

  15. Spectroscopy of asteroid pairs - new observations support previous conclusions

    NASA Astrophysics Data System (ADS)

    Polishook, David; Oszkiewicz, Dagmara Anna; None Kwiatkowski, Tomasz

    2015-08-01

    Asteroid pairs were split due to fast rotation of a strengthless body. Study them can reveal fundamental principles in asteroid interiors and evolution. We continue our spectroscopic survey of asteroid pairs in the near-IR range (IRTF) and work on completing the spectral coverage in the visible wavelength (SALT, NOT).Our new observations support our previous conclusions (Polishook et al. 2014):1. Primary and secondary members have very similar reflectance spectra supporting the claim that every pair originated from a single progenitor. We measured 2 more pairs that present the same taxonomy (4905-7813, 15107-291188). This increases to 22 the number of asteroid pairs with spectral similarities and supports the claim of a single progenitor for each pair to a significance of over 5 sigma.2. Rotational fission is not a function of the asteroid composition rather the asteroid’s structure. We present new reflectance spectra of S- and C-complex pairs that differ in their composition.3. Some asteroid pairs present spectral parameters that imply a fresh, non-weathered surface. This includes spectral slope, and a deep and wide absorption band at 1 micron. Among these, the asteroid 8306 can now be re-classified as a Q-type asteroid, a common class in the near-Earth environment, but rare in the main belt. 8306 is the 4th Q-type discovered within asteroid pairs (all locate in the main belt).4. A secondary member of an asteroid pair composed of ordinary chondrite (S-complex) might present a reflectance spectrum with lower spectral slope compared to its primary member. This is seen in the new measured reflectance spectrum of secondary 291188). This result supports the theory of Jacobson & Scheeres (2011) of continuous disintegration of the secondaries while still in the vicinity of their primaries.5. With time, the fresh surface becomes weathered. Dynamical calculations limit the disintegration time of the progenitor of the pair 4905-7813 to 1.65 millions years ago, what makes

  16. Cosmological Gamma-Ray Bursts and Hypernovae Conclusively Linked

    NASA Astrophysics Data System (ADS)

    2003-06-01

    Clearest-Ever Evidence from VLT Spectra of Powerful Event Summary A very bright burst of gamma-rays was observed on March 29, 2003 by NASA's High Energy Transient Explorer (HETE-II) , in a sky region within the constellation Leo. Within 90 min, a new, very bright light source (the "optical afterglow") was detected in the same direction by means of a 40-inch telescope at the Siding Spring Observatory (Australia) and also in Japan. The gamma-ray burst was designated GRB 030329 , according to the date. And within 24 hours, a first, very detailed spectrum of this new object was obtained by the UVES high-dispersion spectrograph on the 8.2-m VLT KUEYEN telescope at the ESO Paranal Observatory (Chile). It allowed to determine the distance as about 2,650 million light-years (redshift 0.1685). Continued observations with the FORS1 and FORS2 multi-mode instruments on the VLT during the following month allowed an international team of astronomers [1] to document in unprecedented detail the changes in the spectrum of the optical afterglow of this gamma-ray burst . Their detailed report appears in the June 19 issue of the research journal "Nature". The spectra show the gradual and clear emergence of a supernova spectrum of the most energetic class known, a "hypernova" . This is caused by the explosion of a very heavy star - presumably over 25 times heavier than the Sun. The measured expansion velocity (in excess of 30,000 km/sec) and the total energy released were exceptionally high, even within the elect hypernova class. From a comparison with more nearby hypernovae, the astronomers are able to fix with good accuracy the moment of the stellar explosion. It turns out to be within an interval of plus/minus two days of the gamma-ray burst. This unique conclusion provides compelling evidence that the two events are directly connected. These observations therefore indicate a common physical process behind the hypernova explosion and the associated emission of strong gamma

  17. The Alaska earthquake, March 27, 1964: lessons and conclusions

    USGS Publications Warehouse

    Eckel, Edwin B.

    1970-01-01

    local waves. Better earthquake-hazard maps, based on improved knowledge of regional geology, fault behavior, and earthquake mechanisms, are needed for the entire country. Their preparation will require the close collaboration of engineers, seismologists, and geologists. Geologic maps of all inhabited places in earthquake-prone parts of the country are also needed by city planners and others, because the direct relationship between local geology and potential earthquake damage is now well understood. Improved and enlarged nets of earthquake-sensing instruments, sited in relation to known geology, are needed, as are many more geodetic and hydrographic measurements. Every large earthquake, wherever located, should be regarded as a full-scale laboratory experiment whose study can give scientific and engineering information unobtainable from any other source. Plans must be made before the event to insure staffing, funding, and coordination of effort for the scientific and engineering study of future earthquakes. Advice of earth scientists and engineers should be used in the decision-making processes involved in reconstruction after any future disastrous earthquake, as was done after the Alaska earthquake. The volume closes with a selected bibliography and a comprehensive index to the entire series of U.S. Geological Survey Professional Papers 541-546. This is the last in a series of six reports that the U.S. Geological Survey published on the results of a comprehensive geologic study that began, as a reconnaissance survey, within 24 hours after the March 27, 1964, Magnitude 9.2 Great Alaska Earthquake and extended, as detailed investigations, through several field seasons. The 1964 Great Alaska earthquake was the largest earthquake in the U.S. since 1700. Professional Paper 546, in 1 part, describes Lessons and Conclusions.

  18. Qualification of a cyanate ester epoxy blend supplied by Japanese industry for the ITER TF coil insulation

    NASA Astrophysics Data System (ADS)

    Prokopec, R.; Humer, K.; Fillunger, H.; Maix, R. K.; Weber, H. W.; Knaster, J.; Savary, F.

    2012-06-01

    During the last years, two cyanate ester epoxy blends supplied by European and US industry have been successfully qualified for the ITER TF coil insulation. The results of the qualification of a third CE blend supplied by Industrial Summit Technology (IST, Japan) will be presented in this paper. Sets of test samples were fabricated exactly under the same conditions as used before. The reinforcement of the composite consists of wrapped R-glass / polyimide tapes, which are vacuum pressure impregnated with the resin. The mechanical properties of this material were characterized prior to and after reactor irradiation to a fast neutron fluence of 2×1022m-2 (E>0.1 MeV), i.e. twice the ITER design fluence. Static and dynamic tensile as well as static short beam shear tests were carried out at 77 K. In addition, stress strain relations were recorded to determine the Young's modulus at room temperature and at 77 K. The results are compared in detail with the previously qualified materials from other suppliers.

  19. Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism.

    PubMed

    Wöhr, M; Roullet, F I; Crawley, J N

    2011-02-01

    Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.

  20. Neuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism

    PubMed Central

    Meyza, Ksenia; Nikolaev, Tomasz; Kondrakiewicz, Kacper; Blanchard, D. Caroline; Blanchard, Robert J.; Knapska, Ewelina

    2015-01-01

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized, in part, by an inability to adequately respond to social cues. Patients diagnosed with ASD are often devoid of empathy and impaired in understanding other people’s emotional perspective. The neuronal correlates of this impairment are not fully understood. Replicating such a behavioral phenotype in a mouse model of autism would allow us insight into the neuronal background of the problem. Here we tested BTBR T+Itpr3tf/J (BTBR) and c57BL/6J (B6) mice in two behavioral paradigms: the Transfer of Emotional Information test and the Social Proximity test. In both tests BTBR mice displayed asocial behavior. We analyzed c-Fos protein expression in several brain regions after each of these tests, and found that, unlike B6 mice, BTBR mice react to a stressed cagemate exposure in the Transfer of Emotional Information test with no increase of c-Fos expression in either the prefrontal cortex or the amygdala. However, after Social Proximity exposure we observed a strong increase in c-Fos expression in the CA3 field of the hippocampus and two hypothalamic regions of BTBR brains. This response was accompanied by a strong activation of periaqueductal regions related to defensiveness, which suggests that BTBR mice find unavoidable social interaction highly aversive. PMID:26300749

  1. Effects of environmental enrichment on repetitive behaviors in the BTBR T+tf/J mouse model of autism.

    PubMed

    Reynolds, Stacey; Urruela, Meagan; Devine, Darragh P

    2013-10-01

    Lower order and higher order repetitive behaviors have been documented in the BTBR T+tf/J (BTBR) mouse strain, a mouse model that exhibits all three core behavioral domains that define autism. The purpose of this study was to evaluate the effectiveness of environmental enrichment for reducing repetitive behaviors in BTBR mice. Lower order behaviors were captured by assaying the time and sequence of grooming, while higher order behaviors were measured using pattern analysis of an object exploration task from digital recordings. Baseline scores were established at 7 weeks of age, followed by 30 days of housing in either a standard or enriched cage. As expected, BTBR mice spent significantly more time grooming and had a more rigid grooming sequence than control C57BL/6J mice did at baseline. After 30 days of enrichment housing, BTBR mice demonstrated a significant reduction in time spent grooming, resulting in levels that were lower than those exhibited by BTBR mice in standard housing. However, no changes were noted in the rigidity of their grooming sequence. In contrast to previous findings, there was no difference in repetitive patterns of exploration at baseline between BTBR and C57BL/6J mice in the object exploration test. Subsequently, enrichment did not significantly alter the number of repetitive patterns at posttest. Overall, the results suggest that environmental enrichment may be beneficial for reducing the time spent engaging in lower order repetitive behaviors, but may not change the overall quality of the behaviors when they do manifest.

  2. Metabolomic Modeling To Monitor Host Responsiveness to Gut Microbiota Manipulation in the BTBR(T+tf/j) Mouse.

    PubMed

    Klein, Matthias S; Newell, Christopher; Bomhof, Marc R; Reimer, Raylene A; Hittel, Dustin S; Rho, Jong M; Vogel, Hans J; Shearer, Jane

    2016-04-01

    The microbiota, the entirety of microorganisms residing in the gut, is increasingly recognized as an environmental factor in the maintenance of health and the development of disease. The objective of this analysis was to model in vivo interactions between gut microbiota and both serum and liver metabolites. Different genotypic models (C57BL/6 and BTBR(T+tf/j) mice) were studied in combination with significant dietary manipulations (chow vs ketogenic diets) to perturb the gut microbiota. Diet rather than genotype was the primary driver of microbial changes, with the ketogenic diet diminishing total bacterial levels. Fecal but not cecal microbiota profiles were associated with the serum and liver metabolomes. Modeling metabolome-microbiota interactions showed fecal Clostridium leptum to have the greatest impact on host metabolism, significantly correlating with 10 circulating metabolites, including 5 metabolites that did not correlate with any other microbes. C. leptum correlated negatively with serum ketones and positively with glucose and glutamine. Interestingly, microbial groups most strongly correlated with host metabolism were those modulating gut barrier function, the primary site of microbe-host interactions. These results show very robust relationships and provide a basis for future work wherein the compositional and functional associations of the microbiome can be modeled in the context of the metabolome.

  3. Analysis of the heterogeneous dynamics of imidazolium-based [Tf2N-] ionic liquids using molecular simulation

    NASA Astrophysics Data System (ADS)

    Androulaki, Eleni; Vergadou, Niki; Economou, Ioannis G.

    2014-10-01

    The complex dynamic behaviour of the imidazolium-based ionic liquids [Cnmim+][Tf2N-], n = 4, 8, 12 is examined at various temperatures and at atmospheric pressure using molecular dynamics simulation. An existing all-atom force field is further optimised in order to attain reasonable agreement with experimental data for transport properties, such as self-diffusivities and viscosities. Dynamical heterogeneity phenomena are quantified through the calculation of the non-Gaussian parameter and the deviation of the self-part of the van Hove correlation function from the expected normal distribution. From this analysis, ions that move faster or slower than expected are detected in the system. These subsets of 'fast' and 'slow' ions form individual clusters consisting of either mobile or immobile ions. Detailed analysis of the ions' diffusion reveals preferential motion along the direction of the alkyl tail for the cation and along the vector that connects the two sulphur atoms for the anion. For the longest alkyl tails, the heterogeneity in the dynamics becomes more pronounced and is preserved for several nanoseconds, especially at low temperatures.

  4. Implementation of the LAX-Wendroff Method in Cobra-TF for Solving Two-Phase Flow Transport Equations

    SciTech Connect

    Salko, Robert K; Wang, Dean; Ren, Kangyu

    2016-01-01

    COBRA-TF (Coolant Boiling in Rod Arrays Two Fluid), or CTF, is a subchannel code used to conduct the reactor core thermal hydraulic (T/H) solution in both standalone and coupled multi-physics applications. CTF applies the first-order upwind spatial discretization scheme for solving two-phase flow conservation equations. In this work, the second-order Lax-Wendroff (L-W) scheme has been implemented in CTF to solve the two-phase flow transport equations to improve numerical accuracy in both temporal and spatial discretization. To avoid the oscillation issue, a non-linear flux limiter VA (Van Albada) is employed for the convective terms in the transport equations. Assessments have been carried out to evaluate the performance and stability of the implemented second-order L-W scheme. It has been found that the L-W scheme performs better than the upwind scheme for the single-phase and two-phase flow problems in terms of numerical accuracy and computational efficiency.

  5. Mystery Person

    ERIC Educational Resources Information Center

    O'Brien, Tom

    2011-01-01

    This article features a mathematical game called "Mystery Person." The author describes how the Mystery Person game was tried with first-graders [age 6]. The Mystery games involve the generation of key questions, the coordination of information--often very complex information--and the formulation of consequences based on this…

  6. Personal Finance.

    ERIC Educational Resources Information Center

    Wagner, June G.

    2003-01-01

    This newsletter presents four articles designed to help business educators educate learners in grades K-12 about personal finance. "Now More Than Ever: The Need for Financial Literacy" examines the following topics: evidence that the United States is becoming a nation of debtors; the plummeting personal savings rate; the increasing…

  7. Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted).

    PubMed

    Ark, B; Gummere, G; Bennett, D; Artzt, K

    1991-06-01

    Pim-1 is an oncogene activated in mouse T-cell lymphomas induced by Moloney and AKR mink cell focus (MCF) viruses. Pim-1 was previously mapped to chromosome 17 by somatic cell hybrids, and subsequently to the region between the hemoglobin alpha-chain pseudogene 4 (Hba-4ps) and the alpha-crystalline gene (Crya-1) by Southern blot analysis of DNA obtained from panels of recombinant inbred strains. We have now mapped Pim-1 more accurately in t-haplotypes by analysis of recombinant t-chromosomes. The recombinants were derived from Tts6tf/t12 parents backcrossed to + tf/ + tf, and scored for recombination between the loci of T and tf. For simplicity all t-complex lethal genes properly named tcl-tx are shortened to tx. The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes. Once mapped, the Pim-1 gene was used as a marker for further genetic analysis of t-haplotypes. tw12 is so close to tf that even with a large number of recombinants it was not possible to determine whether it is proximal or distal to tf. Southern blot analysis of DNA from T-tf recombinants with a separation of tw12 and tf indicated that tw12 is proximal to tf. The mapping of two allelic t-lethals, t0 and t6 with respect to tw12 and tf has also been a problem.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Evaluation of attenuated PSM photomask blanks with TF11 chrome and FEP-171 resist on a 248 nm DUV laser pattern generator

    NASA Astrophysics Data System (ADS)

    Xing, Kezhao; Björnborg, Charles; Karlsson, Henrik; Paulsson, Adisa; Rosendahl, Anna; Beiming, Peter; Vedenpää, Jukka; Walford, Jonathan; Newman, Tom

    2007-10-01

    Tighter requirements on mask resolution, CD and image positioning accuracy at and beyond the 45 nm technology node push the development of improved photomask blanks. One such blank for attenuated phase-shift masks (att-PSM) provides a thinner chrome film, named TF11, with higher chrome etch rate compared to the previous generation Att- PSM blank (NTAR5 chrome film) from the same supplier. Reduced stress in the chrome film also results in less image placement error induced by the material. FEP-171 is the positive chemically amplified resist (PCAR) that is most commonly used in advanced mask manufacturing with both 50 keV variable shaped e-beam (VSB) and DUV laser pattern generators. TF11 allows an FEP-171 resist film down to about 2000 Å thickness with sufficient etch resistance, while the standard resist thickness for NTAR5 is around 3000 Å. This work has experimentally evaluated the use of TF11 chrome and FEP-171 resist together with a 248 nm DUV laser pattern generator, the Sigma7500. First, patterning performance in resist with thicknesses from 2000 Å to 2600 Å, in steps of 100 Å, was tested with respect to swing curve and basic lithographic parameters including resolution, CD linearity, CD iso-dense bias and dose sensitivity. Patterning results on mask showed a swing minimum at around 2200 Å and a swing maximum at around 2500 Å, which correspond to reflectivity measurements for 248 nm wavelength performed by the blank supplier. It was concluded that the overall patterning performance was best close to the swing maximum. Thereafter the patterning performance using TF11 at two resist thicknesses, 2000 Å and 2550 Å, was studied in more detail and compared to performance using NTAR5 with 3200 Å resist. The evaluation showed that the Sigma7500-II offers good compatibility with TF11, especially using the optimized FEP-171 resist thickness of 2550 Å. It also showed that the patterning capability of the Sigma7500-II using TF11 and 2550 Å resist is improved

  9. Personal Competencies in Personalized Learning

    ERIC Educational Resources Information Center

    Redding, Sam

    2014-01-01

    Personal competencies--cognitive, metacognitive, motivational, and social/emotional--are applied by students in learning (mastery of knowledge and skills). These competencies are both acquired through learning and applied in the learning process. Personalized learning--a promising approach to education made practical by advances in…

  10. Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBRT+tf/j Mouse

    PubMed Central

    Newell, Christopher; Shutt, Timothy E.; Ahn, Younghee; Hittel, Dustin. S.; Khan, Aneal; Rho, Jong M.; Shearer, Jane

    2016-01-01

    The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBRT+tf/j (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochondrial function has become a focal point of research investigating the pathophysiology of ASD. As highly dynamic organelles, mitochondria undergo constant fluctuations in morphology, biogenesis, and quality control in order to maintain cellular homeostasis. An important modifier of mitochondrial dynamics is energy availability. Therefore, the aim of this study was to examine the impact of a KD on mitochondrial dynamics in the liver and brain (prefrontal cortex) of the BTBR mouse model of ASD. Juvenile male C57Bl/6 (B6) and BTBR mice were age-matched to 5 weeks of age before being fed standard chow (CD, 13% kcal fat) or a KD (75% kcal fat) for 10–14 days. Analysis of brain tissue identified differences in mitochondrial gene expression but no correlation with protein levels. Unlike in the brain, KD led to decreased levels of mitochondrial proteins in the liver, despite increased gene expression. Consistent with decreased mitochondrial proteins, we also observed decreased mtDNA for all mice on the KD, demonstrating that the KD reduces the total amount of mitochondria in the liver. In order to explain the discrepancy between protein levels and gene expression, we investigated whether mitochondrial turnover via mitophagy was increased. To this end, we examined expression levels of the mitophagy regulator BNIP3 (BCL2/adenovirus E1B 19 kd-interacting protein 3). BNIP3 gene and protein expression were significantly elevated in liver of KD animals (p < 0.05), indicating the potential activation of mitophagy. Therefore, consumption of a KD exerts highly tissue-specific effects, ultimately increasing mitochondrial turnover in the liver, while gene and protein

  11. Low Stress Reactivity and Neuroendocrine Factors in the BTBR T+tf/J Mouse Model of Autism

    PubMed Central

    Silverman, Jill L.; Yang, Mu; Turner, Sarah M.; Katz, Adam M.; Bell, Dana B.; Koenig, James I.; Crawley, Jacqueline N.

    2010-01-01

    Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+tf/J (BTBR) is an inbred mouse strain that displays robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of autism, including low social interactions, reduced vocalizations in social settings, and high levels of repetitive self-grooming. Autism-relevant phenotypes in BTBR offer translational tools to discover neurochemical mechanisms underlying unusual mouse behaviors relevant to symptoms of autism. Because repetitive self-grooming in mice may be a displacement behavior elevated by stressors, we investigated neuroendocrine markers of stress and behavioral reactivity to stressors in BTBR mice, as compared to C57BL/6J, a standard inbred strain with high sociability. Radioimmunoassays replicated previous findings that circulating corticosterone is higher in the BTBR than in B6. Higher basal glucocorticoid receptor mRNA and higher oxytocin peptide levels were detected in the brains of BTBR as compared to B6. No significant differences were detected in corticotrophin releasing factor (CRF) peptide or CRF mRNA. In response to behavioral stressors, BTBR and B6 were generally similar on behavioral tasks including stress-induced hyperthermia, elevated plus-maze, light ↔ dark exploration, tail flick, acoustic startle and prepulse inhibition. BTBR displayed less reactivity than B6 to a noxious thermal stimulus in the hot plate, and less immobility than B6 in both the forced swim and tail suspension depression-related tasks. BTBR, therefore, exhibited less depression-like scores than B6 on two standard tests sensitive to antidepressants, did not differ from B6 on two well-validated anxiety-like behaviors, and did not exhibit unusual stress reactivity to sensory stimuli. Our findings support the interpretation that autism-relevant social deficits, vocalizations, and

  12. Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBR(T+tf/j) Mouse.

    PubMed

    Newell, Christopher; Shutt, Timothy E; Ahn, Younghee; Hittel, Dustin S; Khan, Aneal; Rho, Jong M; Shearer, Jane

    2016-01-01

    The ketogenic diet (KD) has been utilized as a dietary therapeutic for nearly a century. One experimental model particularly responsive to the KD is the BTBR(T+tf/j) (BTBR) mouse, which displays phenotypic characteristics of autism spectrum disorder (ASD) and insulin resistance. Recently, the study of impaired mitochondrial function has become a focal point of research investigating the pathophysiology of ASD. As highly dynamic organelles, mitochondria undergo constant fluctuations in morphology, biogenesis, and quality control in order to maintain cellular homeostasis. An important modifier of mitochondrial dynamics is energy availability. Therefore, the aim of this study was to examine the impact of a KD on mitochondrial dynamics in the liver and brain (prefrontal cortex) of the BTBR mouse model of ASD. Juvenile male C57Bl/6 (B6) and BTBR mice were age-matched to 5 weeks of age before being fed standard chow (CD, 13% kcal fat) or a KD (75% kcal fat) for 10-14 days. Analysis of brain tissue identified differences in mitochondrial gene expression but no correlation with protein levels. Unlike in the brain, KD led to decreased levels of mitochondrial proteins in the liver, despite increased gene expression. Consistent with decreased mitochondrial proteins, we also observed decreased mtDNA for all mice on the KD, demonstrating that the KD reduces the total amount of mitochondria in the liver. In order to explain the discrepancy between protein levels and gene expression, we investigated whether mitochondrial turnover via mitophagy was increased. To this end, we examined expression levels of the mitophagy regulator BNIP3 (BCL2/adenovirus E1B 19 kd-interacting protein 3). BNIP3 gene and protein expression were significantly elevated in liver of KD animals (p < 0.05), indicating the potential activation of mitophagy. Therefore, consumption of a KD exerts highly tissue-specific effects, ultimately increasing mitochondrial turnover in the liver, while gene and protein

  13. Molecular modeling of imidazolium-based [Tf2N-] ionic liquids: microscopic structure, thermodynamic and dynamic properties, and segmental dynamics.

    PubMed

    Logotheti, Georgia-Evangelia; Ramos, Javier; Economou, Ioannis G

    2009-05-21

    The microscopic structure, thermodynamic properties, local segmental dynamics, and self-diffusion coefficients of three ionic liquids (ILs) with a common anion, namely, the bis(trifluoromethylsulfonyl) imide ([Tf2N-]), and imidazolium-based cations that differ in the alkyl tail length, namely, the 1-butyl-3-methylimidazolium ([C4mim+]), the 1-hexyl-3-methylimidazolium ([C6mim+]), and the 1-octyl-3-methylimidazolium ([C8mim+]), are calculated over the temperature range of 298.15-333.15 K and pressure range of 0.1-60 MPa. Quantum calculations based on density functional theory are performed on isolated ion pairs, and minimum energy conformers are identified. Electronic density results are used to estimate the electrostatic potential of a molecular force field that is used subsequently for long molecular dynamics (MD) simulations of bulk ILs. Thermodynamic properties calculated from MD are shown to be in excellent agreement for the bulk density and good agreement for derivative properties when compared to experimental data. The new force field is an improvement over earlier ones for the same ILs. The microscopic structure as expressed through the radial distribution function is thoroughly calculated, and it is shown that the bulk structure characteristics are very similar to those obtained from the quantum calculations on isolated ion pairs. The segmental dynamics expressed in terms of bond and torsion angle decorrelation is shown to assume a broad range of characteristic times. Molecular segments in the alkyl tail of the cations are significantly faster than segments in the vicinity of the imidazolium ring. Finally, the new force field predicts accurately the self-diffusion coefficients of the cations and the anions over the entire temperature range examined, thus confirming its validity for a broad range of physical properties.

  14. Identification of novel mutations in HFE, HFE2, TfR2, and SLC40A1 genes in Chinese patients affected by hereditary hemochromatosis.

    PubMed

    Wang, Yongwei; Du, Yali; Liu, Gang; Guo, Shanshan; Hou, Bo; Jiang, Xianyong; Han, Bing; Chang, Yanzhong; Nie, Guangjun

    2017-04-01

    Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH in Chinese populations. Thus, there is insufficient patient information for population-based analyses in Chinese populations or comparative studies among different ethical groups. In the current work, we describe eight Chinese cases of hereditary hemochromatosis. Gene sequencing results revealed eight mutations (five novel mutations) in HFE, HFE2, TfR2, and SLC40A1 genes in these Chinese HH patients. In addition, we used Polymorphism Phenotyping v2 (Polyphen), Sorting Intolerant From Tolerant (SIFT), and a sequence alignment program to predict the molecular consequences of missense mutations.

  15. Stress-induced martensitic transformation during tensile test of full-size TF conductor jacket tube at 4.2 K

    SciTech Connect

    Yang, H. H.; Li, S. P.; Wu, Z. X.; Huang, C. J.; Huang, R. J.; Li, L. F.

    2014-01-27

    The toroidal-field (TF) conductor jacket of International Thermonuclear Experimental Reactor (ITER) is made of modified 316LN stainless steel, which is influenced by heat treatment at approximately 650 °C for 200 h to produce Nb{sub 3}Sn superconducting materials at the final stage. Due to the high electromagnetic forces arising during magnet operation, higher mechanical properties of the jacket materials at cryogenic temperatures are required. In our work, mechanical properties of the full-size TF conductor jacket tube were investigated, which satisfied the ITER requirements. Stress-induced martensitic transformation mechanism during tensile test of the conductor jacket material at 4.2 K was characterized by means of in-situ temperature dependent XRD, vibrating sample magnetometer (VSM) and in conjunction with transmission electron microscopy (TEM). The tensile behavior related to the amount of stress-induced phase transformation at cryogenic temperature was also discussed.

  16. Personal Computers.

    ERIC Educational Resources Information Center

    Toong, Hoo-min D.; Gupta, Amar

    1982-01-01

    Describes the hardware, software, applications, and current proliferation of personal computers (microcomputers). Includes discussions of microprocessors, memory, output (including printers), application programs, the microcomputer industry, and major microcomputer manufacturers (Apple, Radio Shack, Commodore, and IBM). (JN)

  17. Modes of Large-Scale Brain Network Organization during Threat Processing and Posttraumatic Stress Disorder Symptom Reduction during TF-CBT among Adolescent Girls

    PubMed Central

    Cisler, Josh M.; Sigel, Benjamin A.; Kramer, Teresa L.; Smitherman, Sonet; Vanderzee, Karin; Pemberton, Joy; Kilts, Clinton D.

    2016-01-01

    Posttraumatic stress disorder (PTSD) is often chronic and disabling across the lifespan. The gold standard treatment for adolescent PTSD is Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT), though treatment response is variable and mediating neural mechanisms are not well understood. Here, we test whether PTSD symptom reduction during TF-CBT is associated with individual differences in large-scale brain network organization during emotion processing. Twenty adolescent girls, aged 11–16, with PTSD related to assaultive violence completed a 12-session protocol of TF-CBT. Participants completed an emotion processing task, in which neutral and fearful facial expressions were presented either overtly or covertly during 3T fMRI, before and after treatment. Analyses focused on characterizing network properties of modularity, assortativity, and global efficiency within an 824 region-of-interest brain parcellation separately during each of the task blocks using weighted functional connectivity matrices. We similarly analyzed an existing dataset of healthy adolescent girls undergoing an identical emotion processing task to characterize normative network organization. Pre-treatment individual differences in modularity, assortativity, and global efficiency during covert fear vs neutral blocks predicted PTSD symptom reduction. Patients who responded better to treatment had greater network modularity and assortativity but lesser efficiency, a pattern that closely resembled the control participants. At a group level, greater symptom reduction was associated with greater pre-to-post-treatment increases in network assortativity and modularity, but this was more pronounced among participants with less symptom improvement. The results support the hypothesis that modularized and resilient brain organization during emotion processing operate as mechanisms enabling symptom reduction during TF-CBT. PMID:27505076

  18. DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1'-linked pyrroloindoline alkaloids.

    PubMed

    Tayu, Masanori; Ishizaki, Takako; Higuchi, Kazuhiro; Kawasaki, Tomomi

    2015-04-07

    The cross-coupling of tryptamine with substituted aniline to access C3a-nitrogen-linked pyrroloindolines has been developed via the consecutive cyclization of tryptamine with DMSO/Tf2O and the substitution of 3a-pyrroloindolylthionium intermediate with aniline. The use of 2,3-dihydrotryptamine instead of aniline enabled easy access to 3a-(1-indolyl)pyrroloindoline and the concise synthesis of C3a-N1'-linked pyrroloindoline alkaloid (±)-psychotriasine was accomplished.

  19. Computational screening of the human TF-glycome provides a structural definition for the specificity of anti-tumor antibody JAA-F11.

    PubMed

    Tessier, Matthew B; Grant, Oliver C; Heimburg-Molinaro, Jamie; Smith, David; Jadey, Snehal; Gulick, Andrew M; Glushka, John; Deutscher, Susan L; Rittenhouse-Olson, Kate; Woods, Robert J

    2013-01-01

    Recombinant antibodies are of profound clinical significance; yet, anti-carbohydrate antibodies are prone to undesirable cross-reactivity with structurally related-glycans. Here we introduce a new technology called Computational Carbohydrate Grafting (CCG), which enables a virtual library of glycans to be assessed for protein binding specificity, and employ it to define the scope and structural origin of the binding specificity of antibody JAA-F11 for glycans containing the Thomsen-Friedenreich (TF) human tumor antigen. A virtual library of the entire human glycome (GLibrary-3D) was constructed, from which 1,182 TF-containing human glycans were identified and assessed for their ability to fit into the antibody combining site. The glycans were categorized into putative binders, or non-binders, on the basis of steric clashes with the antibody surface. The analysis employed a structure of the immune complex, generated by docking the TF-disaccharide (Galβ1-3GalNAcα) into a crystal structure of the JAA-F11 antigen binding fragment, which was shown to be consistent with saturation transfer difference (STD) NMR data. The specificities predicted by CCG were fully consistent with data from experimental glycan array screening, and confirmed that the antibody is selective for the TF-antigen and certain extended core-2 type mucins. Additionally, the CCG analysis identified a limited number of related putative binding motifs, and provided a structural basis for interpreting the specificity. CCG can be utilized to facilitate clinical applications through the determination of the three-dimensional interaction of glycans with proteins, thus augmenting drug and vaccine development techniques that seek to optimize the specificity and affinity of neutralizing proteins, which target glycans associated with diseases including cancer and HIV.

  20. A Preliminary Analysis of TF34-100/400 Jet Engine Rework Data in Support of the MRP System Implementation at NARF Alameda.

    DTIC Science & Technology

    1981-12-01

    requisitions and generating replace- ment probability factors . This information is then used with stock cost projections in a proposed Repair Parts...historical demand 12 data and the effects of utilizing the proposed Repair Parts Inventory Model. The major factors that should be considered in...phase [Ref. 5]. To facilitate the understanding of this code, the TF34 engine will be used as an example. Because of external factors , the material

  1. Personalized ophthalmology

    PubMed Central

    Porter, LF; Black, GCM

    2014-01-01

    Porter L.F., Black G.C.M. Personalized ophthalmology. Clin Genet 2014: 86: 1–11. © 2014 The Authors. Clinical Genetics published by John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., 2014 Ophthalmology has been an early adopter of personalized medicine. Drawing on genomic advances to improve molecular diagnosis, such as next-generation sequencing, and basic and translational research to develop novel therapies, application of genetic technologies in ophthalmology now heralds development of gene replacement therapies for some inherited monogenic eye diseases. It also promises to alter prediction, diagnosis and management of the complex disease age-related macular degeneration. Personalized ophthalmology is underpinned by an understanding of the molecular basis of eye disease. Two important areas of focus are required for adoption of personalized approaches: disease stratification and individualization. Disease stratification relies on phenotypic and genetic assessment leading to molecular diagnosis; individualization encompasses all aspects of patient management from optimized genetic counseling and conventional therapies to trials of novel DNA-based therapies. This review discusses the clinical implications of these twin strategies. Advantages and implications of genetic testing for patients with inherited eye diseases, choice of molecular diagnostic modality, drivers for adoption of personalized ophthalmology, service planning implications, ethical considerations and future challenges are considered. Indeed, whilst many difficulties remain, personalized ophthalmology truly has the potential to revolutionize the specialty. PMID:24665880

  2. Dental students' personality: a Jungian perspective.

    PubMed

    Silberman, S L; Cain, M J; Mahan, J M

    1982-11-01

    The Myers-Briggs Type Indicator (MBTI) was employed to measure the nature and strength of dental students' various basic preference in perceiving and making judgments. The MBTI yields four sets of scores--extrovert-introvert (E-l), sensing-intuitive (S-N), thinking-feeling (T-F), and judging-perceptive (J-P)--and represents 16 personality types that define these preferences. The sample consisted of five classes at the University of Mississippi School of Dentistry (n = 217). The data indicated that the largest group (32 students) was ESFJ, while the next largest (30) was ESTJ. The least frequently represented groups were the INTP (3), the INFP (7), the INTP (7), and the ENTP (7). Dental students exhibited characteristics different from those of students in business, engineering, social work, medicine, and other fields. These findings have implications for admissions committee decisions as well as for the organization and curriculum of the dental school.

  3. Multiple personality disorder.

    PubMed

    Piper, A

    1994-05-01

    Five aspects of the diagnosis and treatment of multiple personality disorder (MPD) were examined. The following five conclusions were made: the contemporary diagnostic criteria are vague and overinclusive; the recent alleged increase in prevalence of the disorder is almost certainly artefactual; legal proceedings involving MPD patients raise disturbing questions about personal responsibility; there is little literature support for the theory that MPD results from childhood trauma; and many of the techniques used to diagnose and treat the condition reinforce its symptoms. A careful revision of diagnostic criteria for the disorder is recommended.

  4. Antisocial personality disorder

    MedlinePlus

    Sociopathic personality; Sociopathy; Personality disorder - antisocial ... are often seen in the development of antisocial personality. Some doctors believe that psychopathic personality (psychopathy) is ...

  5. Personalized ophthalmology.

    PubMed

    Porter, L F; Black, G C M

    2014-07-01

    Ophthalmology has been an early adopter of personalized medicine. Drawing on genomic advances to improve molecular diagnosis, such as next-generation sequencing, and basic and translational research to develop novel therapies, application of genetic technologies in ophthalmology now heralds development of gene replacement therapies for some inherited monogenic eye diseases. It also promises to alter prediction, diagnosis and management of the complex disease age-related macular degeneration. Personalized ophthalmology is underpinned by an understanding of the molecular basis of eye disease. Two important areas of focus are required for adoption of personalized approaches: disease stratification and individualization. Disease stratification relies on phenotypic and genetic assessment leading to molecular diagnosis; individualization encompasses all aspects of patient management from optimized genetic counseling and conventional therapies to trials of novel DNA-based therapies. This review discusses the clinical implications of these twin strategies. Advantages and implications of genetic testing for patients with inherited eye diseases, choice of molecular diagnostic modality, drivers for adoption of personalized ophthalmology, service planning implications, ethical considerations and future challenges are considered. Indeed, whilst many difficulties remain, personalized ophthalmology truly has the potential to revolutionize the specialty.

  6. Personal Finance.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    Developed as part of the Marine Corps Institute (MCI) correspondence training program, this course on personal finance is designed to provide all Marines with the ability to manage their financial affairs successfully. Introductory materials include specific information for MCI students, a course introduction, and a study guide (guidelines to…

  7. Demonstration of thin film pair distribution function analysis (tfPDF) for the study of local structure in amorphous and crystalline thin films

    SciTech Connect

    Jensen, K. M.Ø.; Blichfeld, A. B.; Bauers, S. R.; Wood, S. R.; Dooryhee, E.; Johnson, D. C.; Iversen, B. B.; Billinge, S.

    2015-07-05

    By means of normal incidence, high flux and high energy x-rays, we have obtained total scattering data for Pair Distribution Function (PDF) analysis from thin films (tf), suitable for local structure analysis. By using amorphous substrates as support for the films, the standard Rapid Acquisition PDF setup can be applied and the scattering signal from the film can be isolated from the total scattering data through subtraction of an independently measured background signal. No angular corrections to the data are needed, as would be the case for grazing incidence measurements. We illustrate the ‘tfPDF’ method through studies of as deposited (i.e. amorphous) and crystalline FeSb3 films, where the local structure analysis gives insight into the stabilization of the metastable skutterudite FeSb3 phase. The films were prepared by depositing ultra-thin alternating layers of Fe and Sb, which interdiffuse and after annealing crystallize to form the FeSb3 structure. The tfPDF data show that the amorphous precursor phase consists of corner-sharing FeSb6 octahedra with motifs highly resembling the local structure in crystalline FeSb3. Analysis of the amorphous structure allows predicting whether the final crystalline product will form the FeSb3 phase with or without excess Sb present. The study thus illustrates how analysis of the local structure in amorphous precursor films can help to understand crystallization processes of metastable phases and opens for a range of new local structure studies of thin films.

  8. Demonstration of thin film pair distribution function analysis (tfPDF) for the study of local structure in amorphous and crystalline thin films.

    PubMed

    Jensen, Kirsten M Ø; Blichfeld, Anders B; Bauers, Sage R; Wood, Suzannah R; Dooryhée, Eric; Johnson, David C; Iversen, Bo B; Billinge, Simon J L

    2015-09-01

    By means of normal-incidence, high-flux and high-energy X-rays, total scattering data for pair distribution function (PDF) analysis have been obtained from thin films (tf), suitable for local structure analysis. By using amorphous substrates as support for the films, the standard Rapid Acquisition PDF setup can be applied and the scattering signal from the film can be isolated from the total scattering data through subtraction of an independently measured background signal. No angular corrections to the data are needed, as would be the case for grazing incidence measurements. The 'tfPDF' method is illustrated through studies of as-deposited (i.e. amorphous) and crystalline FeSb3 films, where the local structure analysis gives insight into the stabilization of the metastable skutterudite FeSb3 phase. The films were prepared by depositing ultra-thin alternating layers of Fe and Sb, which interdiffuse and after annealing crystallize to form the FeSb3 structure. The tfPDF data show that the amorphous precursor phase consists of corner-sharing FeSb6 octahedra with motifs highly resembling the local structure in crystalline FeSb3. Analysis of the amorphous structure allows the prediction of whether the final crystalline product will form the FeSb3 phase with or without excess Sb present. The study thus illustrates how analysis of the local structure in amorphous precursor films can help to understand crystallization processes of metastable phases and opens for a range of new local structure studies of thin films.

  9. Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides

    PubMed Central

    2016-01-01

    A shift to short-chain glycans is an observed change in mucin-type O-glycosylation in premalignant and malignant epithelia. Given the evidence that human galectin-3 can interact with mucins and also weakly with free tumor-associated Thomsen-Friedenreich (TF) antigen (CD176), the study of its interaction with MUC1 (glyco)peptides is of biomedical relevance. Glycosylated MUC1 fragments that carry the TF antigen attached through either Thr or Ser side chains were synthesized using standard Fmoc-based automated solid-phase peptide chemistry. The dissociation constants (Kd) for interaction of galectin-3 and the glycosylated MUC1 fragments measured by isothermal titration calorimetry decreased up to 10 times in comparison to that of the free TF disaccharide. No binding was observed for the nonglycosylated control version of the MUC1 peptide. The most notable feature of the binding of MUC1 glycopeptides to galectin-3 was a shift from a favorable enthalpy to an entropy-driven binding process. The comparatively diminished enthalpy contribution to the free energy (ΔG) was compensated by a considerable gain in the entropic term. 1H–15N heteronuclear single-quantum coherence spectroscopy nuclear magnetic resonance data reveal contact at the canonical site mainly by the glycan moiety of the MUC1 glycopeptide. Ligand-dependent differences in binding affinities were also confirmed by a novel assay for screening of low-affinity glycan–lectin interactions based on AlphaScreen technology. Another key finding is that the glycosylated MUC1 peptides exhibited activity in a concentration-dependent manner in cell-based assays revealing selectivity among human galectins. Thus, the presentation of this tumor-associated carbohydrate ligand by the natural peptide scaffold enhances its affinity, highlighting the significance of model studies of human lectins with synthetic glycopeptides. PMID:26129647

  10. Demonstration of thin film pair distribution function analysis (tfPDF) for the study of local structure in amorphous and crystalline thin films

    DOE PAGES

    Jensen, K. M.Ø.; Blichfeld, A. B.; Bauers, S. R.; ...

    2015-07-05

    By means of normal incidence, high flux and high energy x-rays, we have obtained total scattering data for Pair Distribution Function (PDF) analysis from thin films (tf), suitable for local structure analysis. By using amorphous substrates as support for the films, the standard Rapid Acquisition PDF setup can be applied and the scattering signal from the film can be isolated from the total scattering data through subtraction of an independently measured background signal. No angular corrections to the data are needed, as would be the case for grazing incidence measurements. We illustrate the ‘tfPDF’ method through studies of as depositedmore » (i.e. amorphous) and crystalline FeSb3 films, where the local structure analysis gives insight into the stabilization of the metastable skutterudite FeSb3 phase. The films were prepared by depositing ultra-thin alternating layers of Fe and Sb, which interdiffuse and after annealing crystallize to form the FeSb3 structure. The tfPDF data show that the amorphous precursor phase consists of corner-sharing FeSb6 octahedra with motifs highly resembling the local structure in crystalline FeSb3. Analysis of the amorphous structure allows predicting whether the final crystalline product will form the FeSb3 phase with or without excess Sb present. The study thus illustrates how analysis of the local structure in amorphous precursor films can help to understand crystallization processes of metastable phases and opens for a range of new local structure studies of thin films.« less

  11. Demonstration of thin film pair distribution function analysis (tfPDF) for the study of local structure in amorphous and crystalline thin films

    PubMed Central

    Jensen, Kirsten M. Ø.; Blichfeld, Anders B.; Bauers, Sage R.; Wood, Suzannah R.; Dooryhée, Eric; Johnson, David C.; Iversen, Bo B.; Billinge, Simon J. L.

    2015-01-01

    By means of normal-incidence, high-flux and high-energy X-rays, total scattering data for pair distribution function (PDF) analysis have been obtained from thin films (tf), suitable for local structure analysis. By using amorphous substrates as support for the films, the standard Rapid Acquisition PDF setup can be applied and the scattering signal from the film can be isolated from the total scattering data through subtraction of an independently measured background signal. No angular corrections to the data are needed, as would be the case for grazing incidence measurements. The ‘tfPDF’ method is illustrated through studies of as-deposited (i.e. amorphous) and crystalline FeSb3 films, where the local structure analysis gives insight into the stabilization of the metastable skutterudite FeSb3 phase. The films were prepared by depositing ultra-thin alternating layers of Fe and Sb, which interdiffuse and after annealing crystallize to form the FeSb3 structure. The tfPDF data show that the amorphous precursor phase consists of corner-sharing FeSb6 octahedra with motifs highly resembling the local structure in crystalline FeSb3. Analysis of the amorphous structure allows the prediction of whether the final crystalline product will form the FeSb3 phase with or without excess Sb present. The study thus illustrates how analysis of the local structure in amorphous precursor films can help to understand crystallization processes of metastable phases and opens for a range of new local structure studies of thin films. PMID:26306190

  12. Personal Beacon

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The MicroPLB (personal locator beacon) is a search and rescue satellite-aided tracking (SARSAT) transmitter. When activated it emits a distress signal to a constellation of internationally operated satellites. The endangered person's identity and location anywhere on Earth is automatically forwarded to central monitoring stations around the world. It is accurate to within just a few meters. The user uses the device to download navigation data from a global positioning satellite receiver. After the download is complete, the MicroPLB functions as a self-locating beacon. Also, it is the only PLB to use a safe battery. In the past, other PLB devices have used batteries that have enough volatility to explode with extreme force. It was developed by Microwave Monolithic, Inc. through SBIR funding from Glenn Research Center and Goddard Space Flight Center.

  13. Transmission factors for the penetration of neutron and photon fluence into wood-frame dwellings, 1990 (TF90)

    SciTech Connect

    Rhoades, W.A.; Lillie, R.A.; Emmett, M.B.

    1992-05-01

    An earlier study at Oak Ridge calculated radiation doses to persons inside reinforced concrete buildings during the exposure at Nagasaki. The ``DS86`` study conducted at several laboratories in the United States and Japan concentrated on persons inside wood-frame dwellings at both Nagasaki and Hiroshima. The present study is directed toward applying the general technical approach of the DS86. Numerous simplifications were indicated as a result of the earlier research, and the numerical results are represented as ``transmission factors`` relating radiation outside the dwellings to doses received by individuals within. An advantage of this method is that the transmission factors can be presented in tables that can be reviewed, inspected, and applied in a very tangible and straightforward manner.

  14. Transmission factors for the penetration of neutron and photon fluence into wood-frame dwellings, 1990 (TF90)

    SciTech Connect

    Rhoades, W.A.; Lillie, R.A.; Emmett, M.B.

    1992-05-01

    An earlier study at Oak Ridge calculated radiation doses to persons inside reinforced concrete buildings during the exposure at Nagasaki. The DS86'' study conducted at several laboratories in the United States and Japan concentrated on persons inside wood-frame dwellings at both Nagasaki and Hiroshima. The present study is directed toward applying the general technical approach of the DS86. Numerous simplifications were indicated as a result of the earlier research, and the numerical results are represented as transmission factors'' relating radiation outside the dwellings to doses received by individuals within. An advantage of this method is that the transmission factors can be presented in tables that can be reviewed, inspected, and applied in a very tangible and straightforward manner.

  15. Hardware Progress Made in the Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    NASA Technical Reports Server (NTRS)

    VanDyke, Melissa; Martin, James

    2005-01-01

    The EFF-TF provides a facility to experimentally evaluate thermal hydraulic issues through the use of highly effective non-nuclear testing. These techniques provide a rapid, more cost effective method of evaluating designs and support development risk mitigation when concerns are associated with non-nuclear aspects of space nuclear systems. For many systems, electrical resistance thermal simulators can be used to closely mimic the heat deposition of the fission process, providing axial and radial profiles. A number of experimental and design programs were underway in 2004. Initial evaluation of the SAFE-100a (19 module stainless steel/sodium heat pipe reactor with integral gas neat exchanger) was performed with tests up to 17.5 kW of input power at core temperatures of 1000 K. A stainless steel sodium SAFE-100 heat pipe module was placed through repeated freeze/thaw cyclic testing accumulating over 200 restarts to a temperature of 1000 K. Additionally, the design of a 37-fuel pin stainless steel pumped sodium/potassium (NaK) loop was finalized and components procured. Ongoing testing at the EFF-TF is geared towards facilitating both research and development necessary to field a near term space nuclear system. Efforts are coordinated with DOE laboratories, industry, universities, and other NASA centers. This paper describes some of the 2004 efforts.

  16. Hardware Progress Made in the Early Flight Fission Test Facilities (EFF-TF) To Support Near-Term Space Fission Systems

    SciTech Connect

    Van Dyke, Melissa; Martin, James

    2005-02-06

    The NASA Marshall Space Flight Center's Early Flight Fission Test Facility (EFF-TF), provides a facility to experimentally evaluate nuclear reactor related thermal hydraulic issues through the use of non-nuclear testing. This facility provides a cost effective method to evaluate concepts/designs and support mitigation of developmental risk. Electrical resistance thermal simulators can be used to closely mimic the heat deposition of the fission process, providing axial and radial profiles. A number of experimental and design programs were underway in 2004 which include the following. Initial evaluation of the Department of Energy Los Alamos National Laboratory 19 module stainless steel/sodium heat pipe reactor with integral gas heat exchanger was operated at up to 17.5 kW of input power at core temperatures of 1000 K. A stainless steel sodium heat pipe module was placed through repeated freeze/thaw cyclic testing accumulating over 200 restarts to a temperature of 1000 K. Additionally, the design of a 37- pin stainless steel pumped sodium/potassium (NaK) loop was finalized and components procured. Ongoing testing at the EFF-TF is geared towards facilitating both research and development necessary to support future decisions regarding potential use of space nuclear systems for space exploration. All efforts are coordinated with DOE laboratories, industry, universities, and other NASA centers. This paper describes some of the 2004 efforts.

  17. The (3He,tf) as a surrogate reaction to determine (n,f) cross sections in the 10 to 20 MeV energy range

    SciTech Connect

    Basunia, M. S.; Clark, R. M.; Goldblum, B. L.; Bernstein, L. A.; Phair, L.; Burke, J. T.; Beausang, C. W.; Bleuel, D. L.; Darakchieva, B.; Dietrich, F. S.; Evtimova, M.; Fallon, P.; Gibelin, J.; Hatarik, R.; Jewett, C. C.; Lesher, S. R.; McMahan, M. A.; Rodriguez-Vieitez, E.; Wiedeking, M.

    2009-02-25

    The surrogate reaction 238U(3He,tf) is used to determine the 237Np(n,f) cross section indirectly over an equivalent neutron energy range from 10 to 20 MeV. A self-supporting ~;;761 mu g/cm2 metallic 238U foil was bombarded with a 42 MeV 3He2+ beam from the 88-Inch Cyclotron at Lawrence Berkeley National Laboratory (LBNL). Outgoing charged particles and fission fragments were identified using the Silicon Telescope Array for Reaction Studies (STARS), consists of two 140 mu m and one 1000 mu m Micron S2 type silicon detectors. The 237Np(n,f) cross sections, determined indirectly, were compared with the 237Np(n,f) cross section data from direct measurements, the Evaluated Nuclear Data File (ENDF/B-VII.0), and the Japanese Evaluated Nuclear Data Library (JENDL 3.3) and found to closely follow those datasets. Use of the (3He,tf) reaction as a surrogate to extract (n,f) cross section in the 10 to 20 MeV equivalent neutron energy is found to be suitable.

  18. Personalized pseudophakic model

    NASA Astrophysics Data System (ADS)

    Ribeiro, F.; Castanheira-Dinis, A.; Dias, J. M.

    2014-08-01

    With the aim of taking into account all optical aberrations, a personalized pseudophakic optical model was designed for refractive evaluation using ray tracing software. Starting with a generic model, all clinically measurable data were replaced by personalized measurements. Data from corneal anterior and posterior surfaces were imported from a grid of elevation data obtained by topography, and a formula for the calculation of the intraocular lens (IOL) position was developed based on the lens equator. For the assessment of refractive error, a merit function minimized by the approximation of the Modulation Transfer Function values to diffraction limit values on the frequencies corresponding up to the discrimination limits of the human eye, weighted depending on the human contrast sensitivity function, was built. The model was tested on the refractive evaluation of 50 pseudophakic eyes. The developed model shows good correlation with subjective evaluation of a pseudophakic population, having the added advantage of being independent of corrective factors, allowing it to be immediately adaptable to new technological developments. In conclusion, this personalized model, which uses individual biometric values, allows for a precise refractive assessment and is a valuable tool for an accurate IOL power calculation, including in conditions to which population averages and the commonly used regression correction factors do not apply, thus achieving the goal of being both personalized and universally applicable.

  19. Schizotypal Personality Disorder

    MedlinePlus

    Schizotypal personality disorder Overview By Mayo Clinic Staff People with schizotypal personality disorder are often described as odd or eccentric ... in social situations, as the person with schizotypal personality disorder responds inappropriately to social cues and holds ...

  20. Dual single-scission event analysis of constitutive transferrin receptor (TfR) endocytosis and ligand-triggered β2-adrenergic receptor (β2AR) or Mu-opioid receptor (MOR) endocytosis.

    PubMed

    Lampe, Marko; Pierre, Fabienne; Al-Sabah, Suleiman; Krasel, Cornelius; Merrifield, Christien J

    2014-10-01

    The dynamic relationship between constitutive and ligand-triggered clathrin-mediated endocytosis is only poorly characterized, and it remains controversial whether clathrin-coated pits specialize to internalize particular receptor cargo. Here we analyzed the ligand-triggered endocytosis of the model G-protein-coupled receptors (GPCRs) β2-adrenergic receptor (β2AR) and Mu-opioid receptor (MOR) at the level of individual endocytic events using a total internal reflection fluorescence microscopy (TIRFM)-based assay. Similar to the constitutive endocytosis of transferrin receptor (TfR), ligand- triggered endocytosis of β2AR occurs via quantized scission events hosted by clathrin spots and plaques of variable size and persistence. To address whether clathrin-coated structures (CCSs) specialize to internalize particular GPCRs, we adapted the TIRFM imaging assay to simultaneously quantify the internalization of TfR and the ligand- triggered endocytosis of the β2AR or MOR. Agonist-triggered β2AR or MOR endocytosis extended the maturation time of CCSs, as shown previously, but did not affect the rate of constitutive TfR endocytosis or loading of TfR into individual endocytic vesicles. Both the β2AR and the MOR receptors entered cells in the same vesicles as TfR, and the overall evidence for CCS specialization was weak. These data support a simple model in which different cargoes internalize through common CCSs.

  1. Dual single-scission event analysis of constitutive transferrin receptor (TfR) endocytosis and ligand-triggered β2-adrenergic receptor (β2AR) or Mu-opioid receptor (MOR) endocytosis

    PubMed Central

    Lampe, Marko; Pierre, Fabienne; Al-Sabah, Suleiman; Krasel, Cornelius; Merrifield, Christien J.

    2014-01-01

    The dynamic relationship between constitutive and ligand-triggered clathrin-mediated endocytosis is only poorly characterized, and it remains controversial whether clathrin-coated pits specialize to internalize particular receptor cargo. Here we analyzed the ligand-triggered endocytosis of the model G-protein–coupled receptors (GPCRs) β2-adrenergic receptor (β2AR) and Mu-opioid receptor (MOR) at the level of individual endocytic events using a total internal reflection fluorescence microscopy (TIRFM)–based assay. Similar to the constitutive endocytosis of transferrin receptor (TfR), ligand- triggered endocytosis of β2AR occurs via quantized scission events hosted by clathrin spots and plaques of variable size and persistence. To address whether clathrin-coated structures (CCSs) specialize to internalize particular GPCRs, we adapted the TIRFM imaging assay to simultaneously quantify the internalization of TfR and the ligand- triggered endocytosis of the β2AR or MOR. Agonist-triggered β2AR or MOR endocytosis extended the maturation time of CCSs, as shown previously, but did not affect the rate of constitutive TfR endocytosis or loading of TfR into individual endocytic vesicles. Both the β2AR and the MOR receptors entered cells in the same vesicles as TfR, and the overall evidence for CCS specialization was weak. These data support a simple model in which different cargoes internalize through common CCSs. PMID:25079691

  2. Multiple Conserved Domains of the Nucleoporin Nup124p and Its Orthologs Nup1p and Nup153 Are Critical for Nuclear Import and Activity of the Fission Yeast Tf1 Retrotransposon

    PubMed Central

    Sistla, Srivani; Pang, Junxiong Vincent; Wang, Cui Xia

    2007-01-01

    The nucleoporin Nup124p is a host protein required for the nuclear import of both, retrotransposon Tf1-Gag as well as the retroviral HIV-1 Vpr in fission yeast. The human nucleoporin Nup153 and the Saccharomyces cerevisiae Nup1p were identified as orthologs of Nup124p. In this study, we show that all three nucleoporins share a large FG/FXFG-repeat domain and a C-terminal peptide sequence, GRKIxxxxxRRKx, that are absolutely essential for Tf1 retrotransposition. Though the FXFG domain was essential, the FXFG repeats themselves could be eliminated without loss of retrotransposon activity, suggesting the existence of a common element unrelated to FG/FXFG motifs. The Nup124p C-terminal peptide, GRKIAVPRSRRKR, was extremely sensitive to certain single amino acid changes within stretches of the basic residues. On the basis of our comparative study of Nup124p, Nup1p, and Nup153 domains, we have developed peptides that specifically knockdown retrotransposon activity by disengaging the Tf1-Gag from its host nuclear transport machinery without any harmful consequence to the host itself. Our results imply that those domains challenged a specific pathway affecting Tf1 transposition. Although full-length Nup1p or Nup153 does not complement Nup124p, the functionality of their conserved domains with reference to Tf1 activity suggests that these three proteins evolved from a common ancestor. PMID:17615301

  3. Predictive value of attitude, cognitive ability, and personality to science achievement in the middle school

    NASA Astrophysics Data System (ADS)

    Baker, Dale R.

    This article examines the factors of attitude toward science, spatial ability, mathematical ability, and the scientific personality, as measured by the Myers-Briggs Type Indicator, in a sample of middle school students. Males and females with science grades of A and B were found to have several characteristics of the scientific personality, good grades in mathematics, but negative attitudes toward science. Males and females with science grades of C and D had a more positive attitude toward science, but poor mathematical and spatial abilities and few characteristics of the scientific personality. There were no sex differences except on the Thinking/Feeling (TF) scale of the Myers-Briggs Type Indicator. As expected females portrayed themselves as preferring the (F) scale, the use of personal values when making decisions and males portrayed themselves as preferring the (T) scale, the use of logical analysis when making decisions.

  4. 10 CFR 709.16 - Application of Counterintelligence Evaluation Review Boards in reaching conclusions regarding CI...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY COUNTERINTELLIGENCE EVALUATION PROGRAM CI Evaluation Protocols and Protection of National Security... covered person, the DOE Office of Health, Safety and Security and security directors for the DOE or...

  5. Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.

    PubMed

    Shpyleva, Svitlana; Ivanovsky, Samuil; de Conti, Aline; Melnyk, Stepan; Tryndyak, Volodymyr; Beland, Frederick A; James, S Jill; Pogribny, Igor P

    2014-01-01

    The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and understanding the molecular processes underlying the pathogenesis of autism is critical for effective clinical management and prevention of this disorder. The goal of this study is to investigate key molecular alterations postulated to play a role in autism and their role in the pathophysiology of autism. In this study we demonstrate that DNA isolated from the cerebellum of BTBR T+tf/J mice, a relevant mouse model of autism, and from human post-mortem cerebellum of individuals with autism, are both characterized by an increased levels of 8-oxo-7-hydrodeoxyguanosine (8-oxodG), 5-methylcytosine (5mC), and 5-hydroxymethylcytosine (5hmC). The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b). Interestingly, a rise in the level of 5hmC occurred without changes in the expression of ten-eleven translocation expression 1 (Tet1) and Tet2 genes, but significantly correlated with the presence of 8-oxodG in DNA. This finding and similar elevation in 8-oxodG in cerebellum of individuals with autism and in the BTBR T+tf/J mouse model warrant future large-scale studies to specifically address the role of OGG1 alterations in pathogenesis of autism.

  6. Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum

    PubMed Central

    Shpyleva, Svitlana; Ivanovsky, Samuil; de Conti, Aline; Melnyk, Stepan; Tryndyak, Volodymyr; Beland, Frederick A.; James, S. Jill; Pogribny, Igor P.

    2014-01-01

    The molecular pathogenesis of autism is complex and involves numerous genomic, epigenomic, proteomic, metabolic, and physiological alterations. Elucidating and understanding the molecular processes underlying the pathogenesis of autism is critical for effective clinical management and prevention of this disorder. The goal of this study is to investigate key molecular alterations postulated to play a role in autism and their role in the pathophysiology of autism. In this study we demonstrate that DNA isolated from the cerebellum of BTBR T+tf/J mice, a relevant mouse model of autism, and from human post-mortem cerebellum of individuals with autism, are both characterized by an increased levels of 8-oxo-7-hydrodeoxyguanosine (8-oxodG), 5-methylcytosine (5mC), and 5-hydroxymethylcytosine (5hmC). The increase in 8-oxodG and 5mC content was associated with a markedly reduced expression of the 8-oxoguanine DNA-glycosylase 1 (Ogg1) and increased expression of de novo DNA methyltransferases 3a and 3b (Dnmt3a and Dnmt3b). Interestingly, a rise in the level of 5hmC occurred without changes in the expression of ten-eleven translocation expression 1 (Tet1) and Tet2 genes, but significantly correlated with the presence of 8-oxodG in DNA. This finding and similar elevation in 8-oxodG in cerebellum of individuals with autism and in the BTBR T+tf/J mouse model warrant future large-scale studies to specifically address the role of OGG1 alterations in pathogenesis of autism. PMID:25423485

  7. Photophysical and redox properties of a series of phthalocyanines: relation with their photodynamic activities on TF-1 and Daudi leukemic cells.

    PubMed

    Daziano, J P; Steenken, S; Chabannon, C; Mannoni, P; Chanon, M; Julliard, M

    1996-10-01

    The photodynamic therapy (PDT) efficiency of five phthalocyanines, chloroaluminum phthalocyanine (AlPc), dichlorosilicon phthalocyanine (SiPc), bis(tri-n-hexylsiloxy)silicon phthalocyanine (PcHEX), bis(triphenylsiloxy)silicon phthalocyanine (PcPHE) and nickel phthalocyanine (NiPc), was assessed on two leukemic cell lines TF-1 and erythroleukemic and B lymphoblastic cell lines, Daudi, respectively. AlPc showed the best photocytotoxicity leading to 0.008 surviving fraction at 2 x 10(-9) M for TF-1 and 4 x 10(-9) M for Daudi. A1 5 x 10(-7) M, SiPc and PcHEX induced a significant photokilling, whereas NiPc and PcPHE were inactive. Laser flash photolysis and photoredox properties of the phthalocyanines were investigated to try to relate these parameters with the biological effects. AlPc showed the longest triplet life-time: 484 microseconds in dimethyl sulfoxide/H2O. This value was increased up to 820 microseconds when AlPc was complexed with human serum albumin used as a membrane model. Such an enhancement was not observed with the silicon phthalocyanines. Upon irradiation, all the phthalocyanines generated singlet oxygen with 0.29-0.37 quantum yield values. The reduction potentials of the excited states obtained from measurement in the ground state and energy of the excited triplets show that AlPc is the best electron acceptor. The in vitro photocytotoxicity observed and the measured parameters are in agreement with a key role of electron transfer in PDT assays involving these phthalocyanines.

  8. Anaemia in older persons.

    PubMed

    den Elzen, W P J; Gussekloo, J

    2011-06-01

    Anaemia is common in older individuals and, because of its association with various negative outcomes, adequate diagnosis and treatment is important. The present review focuses on prominent factors included in diagnostic and therapeutic algorithms for anaemia. Although pernicious anaemia is associated with severe vitamin B12 deficiency, evidence of an association between subnormal vitamin B12 and anaemia in older persons in the general population is limited and inconclusive. Accumulating evidence suggests that clinicians should at least reconsider the risks of a low vitamin B12 level before starting vitamin B12 supplementation in older individuals. Although clinicians may be reluctant to measure ferritin in older individuals due to its acute phase properties, such measurements are important in older persons with anaemia, especially in those with signs of inflammation. While a severe age-related decline in renal function may lead to a blunted erythropoietin response and anaemia, elevated erythropoietin levels are associated with increased mortality. More studies are needed to identify the clinical relevance and therapeutic implications of low and high erythropoietin levels in older persons. In contrast to other age-related diseases, telomere length is not associated with anaemia in older individuals in the general population. In conclusion, many issues regarding the aetiology of anaemia in old age remain unresolved. Because current guidelines on anaemia are based on the classic notions of the aetiology of anaemia, they may need to be revised for the highest age groups.

  9. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  10. 43 CFR 4.477 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Findings and conclusions; decision by... Grazing Procedures (inside and Outside Grazing Districts) § 4.477 Findings and conclusions; decision by... conclusions, the administrative law judge will make findings of fact and conclusions of law, unless waiver...

  11. 43 CFR 4.477 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Findings and conclusions; decision by... Grazing Procedures (inside and Outside Grazing Districts) § 4.477 Findings and conclusions; decision by... conclusions, the administrative law judge will make findings of fact and conclusions of law, unless waiver...

  12. 47 CFR 1.264 - Contents of findings of fact and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Contents of findings of fact and conclusions. 1... Hearing Proceedings Hearing and Intermediate Decision § 1.264 Contents of findings of fact and conclusions... conclusions proposed by the party filing same. Proposed conclusions shall be separately stated....

  13. 43 CFR 4.477 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Findings and conclusions; decision by... Grazing Procedures (inside and Outside Grazing Districts) § 4.477 Findings and conclusions; decision by... conclusions, the administrative law judge will make findings of fact and conclusions of law, unless waiver...

  14. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if no... upon the other participants proposed findings of fact and conclusions of law, comments in...

  15. 47 CFR 1.264 - Contents of findings of fact and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Contents of findings of fact and conclusions. 1... Hearing Proceedings Hearing and Intermediate Decision § 1.264 Contents of findings of fact and conclusions... conclusions proposed by the party filing same. Proposed conclusions shall be separately stated....

  16. 43 CFR 4.477 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Findings and conclusions; decision by... Grazing Procedures (inside and Outside Grazing Districts) § 4.477 Findings and conclusions; decision by... conclusions, the administrative law judge will make findings of fact and conclusions of law, unless waiver...

  17. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  18. 47 CFR 1.264 - Contents of findings of fact and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Contents of findings of fact and conclusions. 1... Hearing Proceedings Hearing and Intermediate Decision § 1.264 Contents of findings of fact and conclusions... conclusions proposed by the party filing same. Proposed conclusions shall be separately stated....

  19. 18 CFR 385.912 - Proposed findings of fact, conclusions of law, and comments (Rule 912).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... fact, conclusions of law, and comments (Rule 912). 385.912 Section 385.912 Conservation of Power and..., conclusions of law, and comments (Rule 912). (a) Within 10 days after the conclusion of the hearing, or, if no... upon the other participants proposed findings of fact and conclusions of law, comments in...

  20. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  1. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  2. 39 CFR 953.11 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Proposed findings of fact and conclusions of law... PROCEEDINGS RELATIVE TO MAILABILITY § 953.11 Proposed findings of fact and conclusions of law. Proposed findings of fact and conclusions of law shall be submitted orally or in writing at the conclusion of...

  3. High maternal choline consumption during pregnancy and nursing alleviates deficits in social interaction and improves anxiety-like behaviors in the BTBR T+Itpr3tf/J mouse model of autism.

    PubMed

    Langley, Erika A; Krykbaeva, Marina; Blusztajn, Jan Krzysztof; Mellott, Tiffany J

    2015-02-01

    Autism is a neurodevelopmental disorder with multiple genetic and environmental risk factors. Choline is a fundamental nutrient for brain development and high choline intake during prenatal and/or early postnatal periods is neuroprotective. We examined the effects of perinatal choline supplementation on social behavior, anxiety, and repetitive behaviors in the BTBR T+Itpr3tf/J (BTBR) mouse model of autism. The BTBR or the more "sociable" C57BL/6J (B6) strain females were fed a control or choline-supplemented diet from mating, throughout pregnancy and lactation. After weaning to a control diet, all offspring were evaluated at one or two ages [postnatal days 33-36 and 89-91] using open field (OF), elevated plus maze (EPM), marble burying (MB), and three-chamber social interaction tests. As expected, control-diet BTBR mice displayed higher OF locomotor activity, impaired social preference, and increased digging behavior during the MB test compared to control-diet B6 mice. Choline supplementation significantly decreased digging behavior, elevated the percentage of open arm entries and time spent in open arms in the EPM by BTBR mice, but had no effect on locomotion. Choline supplementation did not alter social interaction in B6 mice but remarkably improved impairments in social interaction in BTBR mice at both ages, indicating that the benefits of supplementation persist long after dietary choline returns to control levels. In conclusion, our results suggest that high choline intake during early development can prevent or dramatically reduce deficits in social behavior and anxiety in an autistic mouse model, revealing a novel strategy for the treatment/prevention of autism spectrum disorders.

  4. Studies of Astrology and Personality.

    ERIC Educational Resources Information Center

    Kelley, I.W.

    1979-01-01

    Reviews the behavioral evidence of the possible relationship between the movements of the planets and personality variables. Concludes that astrology is a science consisting primarily of false data claims and much further research is required before any supported conclusions can be reached. (Author)

  5. Histrionic personality disorder

    MedlinePlus

    Personality disorder - histrionic; Attention seeking - histrionic personality disorder ... Causes of histrionic personality disorder are unknown. Genes and early childhood events may be responsible. It is diagnosed more often in women than ...

  6. Schizoid Personality Disorder

    MedlinePlus

    Schizoid personality disorder Overview By Mayo Clinic Staff Schizoid personality disorder is an uncommon condition in which people avoid ... range of emotional expression. If you have schizoid personality disorder, you may be seen as a loner ...

  7. Sequential Friedel-Crafts-Type α-Amidoalkylation/Intramolecular Hydroarylation: Distinct Advantage of Combined Tf2NH/Cationic LAu(I) as a Consecutive or Binary Bicatalytic System.

    PubMed

    Boiaryna, Liliana; Azizi, Mohamed Salah; El Bouakher, Abderrahman; Picard, Baptiste; Taillier, Catherine; Othman, Mohamed; Trabelsi-Ayadi, Malika; Dalla, Vincent

    2015-05-01

    The combined use of Tf2NH and L(Au)(+)X(-) as a dual or binary catalytic system clearly improves the efficiency and enlarges the scope of the tandem intermolecular Friedel-Crafts α-amidoalkylation/intramolecular hydroarylation sequence, compared to an "all gold" multicatalysis approach.

  8. 12 CFR 390.21 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Proposed findings and conclusions and... conclusions and recommended decision. (a) Within 30 days after completion of oral argument or the submission...) presented, (2) A statement of findings and conclusions, and the reasons or basis therefor, on all...

  9. 43 CFR 4.452-8 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Findings and conclusions; decision by... Hearings on Appeals Involving Questions of Fact § 4.452-8 Findings and conclusions; decision by administrative law judge. (a) At the conclusion of the testimony the parties at the hearing shall be given...

  10. 40 CFR 78.17 - Proposed findings and conclusions and supporting brief.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Proposed findings and conclusions and...) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.17 Proposed findings and conclusions and supporting... is available, any party may file with the Hearing Clerk proposed findings and conclusions on...

  11. 20 CFR 725.417 - Action at the conclusion of conference.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Action at the conclusion of conference. 725.417 Section 725.417 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR... § 725.417 Action at the conclusion of conference. (a) At the conclusion of a conference, the...

  12. 39 CFR 964.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party to a proceeding, except one who fails to answer the..., submit proposed findings of fact, conclusions of law, orders and supporting reasons either in oral...

  13. 20 CFR 725.417 - Action at the conclusion of conference.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Action at the conclusion of conference. 725.417 Section 725.417 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR... § 725.417 Action at the conclusion of conference. (a) At the conclusion of a conference, the...

  14. 12 CFR 508.12 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Proposed findings and conclusions and... findings and conclusions and recommended decision. (a) Within 30 days after completion of oral argument or..., (2) A statement of findings and conclusions, and the reasons or basis therefor, on all...

  15. 43 CFR 4.452-8 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Findings and conclusions; decision by... Hearings on Appeals Involving Questions of Fact § 4.452-8 Findings and conclusions; decision by administrative law judge. (a) At the conclusion of the testimony the parties at the hearing shall be given...

  16. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Proposed findings, conclusions and... PENALTIES REGULATIONS Trading With the Enemy Act (TWEA) Penalties § 501.735 Proposed findings, conclusions... writing proposed findings and conclusions. (b) Procedure. Proposed findings of fact must be supported...

  17. 49 CFR 386.57 - Proposed findings of fact, conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Proposed findings of fact, conclusions of law. 386... HAZARDOUS MATERIALS PROCEEDINGS General Rules and Hearings § 386.57 Proposed findings of fact, conclusions... proposed findings of fact, conclusions of law, and supporting reasons therefor. If the administrative...

  18. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  19. 37 CFR 11.53 - Proposed findings and conclusions; post-hearing memorandum.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... conclusions; post-hearing memorandum. 11.53 Section 11.53 Patents, Trademarks, and Copyrights UNITED STATES..., Investigations, and Proceedings § 11.53 Proposed findings and conclusions; post-hearing memorandum. Except in... proposed findings and conclusions and a post-hearing memorandum in support of the proposed findings...

  20. 12 CFR 390.21 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Proposed findings and conclusions and... conclusions and recommended decision. (a) Within 30 days after completion of oral argument or the submission...) presented, (2) A statement of findings and conclusions, and the reasons or basis therefor, on all...

  1. 17 CFR 201.340 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Proposed findings, conclusions... findings, conclusions and supporting briefs. (a) Opportunity to file. Before an initial decision is issued... proposed findings and conclusions together with, or as a part of, its brief. (b) Procedure....

  2. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210....40 Proposed findings and conclusions and briefs. At the time a motion for summary determination under... administrative law judge, any party may file proposed findings of fact and conclusions of law, together...

  3. 37 CFR 11.53 - Proposed findings and conclusions; post-hearing memorandum.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... conclusions; post-hearing memorandum. 11.53 Section 11.53 Patents, Trademarks, and Copyrights UNITED STATES..., Investigations, and Proceedings § 11.53 Proposed findings and conclusions; post-hearing memorandum. Except in... proposed findings and conclusions and a post-hearing memorandum in support of the proposed findings...

  4. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Proposed findings, conclusions and... PENALTIES REGULATIONS Trading With the Enemy Act (TWEA) Penalties § 501.735 Proposed findings, conclusions... writing proposed findings and conclusions. (b) Procedure. Proposed findings of fact must be supported...

  5. 49 CFR 386.57 - Proposed findings of fact, conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Proposed findings of fact, conclusions of law. 386... HAZARDOUS MATERIALS PROCEEDINGS General Rules and Hearings § 386.57 Proposed findings of fact, conclusions... proposed findings of fact, conclusions of law, and supporting reasons therefor. If the administrative...

  6. 45 CFR 81.101 - Posthearing briefs: Proposed findings and conclusions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... conclusions. 81.101 Section 81.101 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... § 81.101 Posthearing briefs: Proposed findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of...

  7. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2... Procedures for NRC Adjudications § 2.1209 Findings of fact and conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions of law on the contentions addressed in...

  8. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative... and conclusions of law together with a supporting brief at a time designated by the administrative...

  9. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Conclusion by physician regarding miner's... to Pneumoconiosis § 410.471 Conclusion by physician regarding miner's disability or death. The... statement of similar import, being a conclusion upon the ultimate issue to be decided by the...

  10. 39 CFR 964.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party to a proceeding, except one who fails to answer the..., submit proposed findings of fact, conclusions of law, orders and supporting reasons either in oral...

  11. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Proposed findings and conclusions and briefs. 210....40 Proposed findings and conclusions and briefs. At the time a motion for summary determination under... administrative law judge, any party may file proposed findings of fact and conclusions of law, together...

  12. 30 CFR 44.31 - Proposed findings of fact, conclusions, and orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Proposed findings of fact, conclusions, and... MANDATORY SAFETY STANDARDS Hearings § 44.31 Proposed findings of fact, conclusions, and orders. After... each party may file proposed findings of fact, conclusions of law, and rule or order, together with...

  13. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative... and conclusions of law together with a supporting brief at a time designated by the administrative...

  14. 17 CFR 201.340 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Proposed findings, conclusions... findings, conclusions and supporting briefs. (a) Opportunity to file. Before an initial decision is issued... proposed findings and conclusions together with, or as a part of, its brief. (b) Procedure....

  15. 12 CFR 622.12 - Proposed findings and conclusions; recommended decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Proposed findings and conclusions; recommended... PRACTICE AND PROCEDURE Rules Applicable to Formal Hearings § 622.12 Proposed findings and conclusions; recommended decision. (a) Proposed findings and conclusions by parties. Within 30 days after the...

  16. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Proposed findings, conclusions and... PENALTIES REGULATIONS Trading With the Enemy Act (TWEA) Penalties § 501.735 Proposed findings, conclusions... writing proposed findings and conclusions. (b) Procedure. Proposed findings of fact must be supported...

  17. 21 CFR 1316.64 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Proposed findings of fact and conclusions of law... and conclusions of law. Any party in the hearing may file in quintuplicate proposed findings of fact and conclusions of law within the time fixed by the presiding officer. Any party so filing shall...

  18. 12 CFR 622.12 - Proposed findings and conclusions; recommended decision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Proposed findings and conclusions; recommended... PRACTICE AND PROCEDURE Rules Applicable to Formal Hearings § 622.12 Proposed findings and conclusions; recommended decision. (a) Proposed findings and conclusions by parties. Within 30 days after the...

  19. 38 CFR 18b.70 - Posthearing briefs; proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...; proposed findings and conclusions. 18b.70 Section 18b.70 Pensions, Bonuses, and Veterans' Relief DEPARTMENT... findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of law, and, if permitted, reply briefs....

  20. 37 CFR 11.53 - Proposed findings and conclusions; post-hearing memorandum.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... conclusions; post-hearing memorandum. 11.53 Section 11.53 Patents, Trademarks, and Copyrights UNITED STATES..., Investigations, and Proceedings § 11.53 Proposed findings and conclusions; post-hearing memorandum. Except in... proposed findings and conclusions and a post-hearing memorandum in support of the proposed findings...

  1. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  2. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative... and conclusions of law together with a supporting brief at a time designated by the administrative...

  3. 17 CFR 201.340 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Proposed findings, conclusions... findings, conclusions and supporting briefs. (a) Opportunity to file. Before an initial decision is issued... proposed findings and conclusions together with, or as a part of, its brief. (b) Procedure....

  4. 19 CFR 210.63 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210... and conclusions and briefs. The administrative law judge shall determine whether and, if so, to what extent the parties shall be permitted to file proposed findings of fact, proposed conclusions of law,...

  5. 12 CFR 390.21 - Proposed findings and conclusions and recommended decision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Proposed findings and conclusions and... conclusions and recommended decision. (a) Within 30 days after completion of oral argument or the submission...) presented, (2) A statement of findings and conclusions, and the reasons or basis therefor, on all...

  6. 40 CFR 78.17 - Proposed findings and conclusions and supporting brief.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Proposed findings and conclusions and...) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.17 Proposed findings and conclusions and supporting... is available, any party may file with the Hearing Clerk proposed findings and conclusions on...

  7. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Proposed findings and conclusions and briefs. 210....40 Proposed findings and conclusions and briefs. At the time a motion for summary determination under... administrative law judge, any party may file proposed findings of fact and conclusions of law, together...

  8. 38 CFR 18b.70 - Posthearing briefs; proposed findings and conclusions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...; proposed findings and conclusions. 18b.70 Section 18b.70 Pensions, Bonuses, and Veterans' Relief DEPARTMENT... findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of law, and, if permitted, reply briefs....

  9. 43 CFR 4.452-8 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false Findings and conclusions; decision by... Hearings on Appeals Involving Questions of Fact § 4.452-8 Findings and conclusions; decision by administrative law judge. (a) At the conclusion of the testimony the parties at the hearing shall be given...

  10. 20 CFR 725.417 - Action at the conclusion of conference.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Action at the conclusion of conference. 725.417 Section 725.417 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR... § 725.417 Action at the conclusion of conference. (a) At the conclusion of a conference, the...

  11. 45 CFR 81.101 - Posthearing briefs: Proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... conclusions. 81.101 Section 81.101 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... § 81.101 Posthearing briefs: Proposed findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of...

  12. 39 CFR 963.17 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party who participates in the hearing may, unless the presiding officer orders otherwise, submit proposed findings of fact, conclusions of law, orders,...

  13. 38 CFR 18b.70 - Posthearing briefs; proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...; proposed findings and conclusions. 18b.70 Section 18b.70 Pensions, Bonuses, and Veterans' Relief DEPARTMENT... findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of law, and, if permitted, reply briefs....

  14. 17 CFR 201.340 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Proposed findings, conclusions... findings, conclusions and supporting briefs. (a) Opportunity to file. Before an initial decision is issued... proposed findings and conclusions together with, or as a part of, its brief. (b) Procedure....

  15. 20 CFR 725.417 - Action at the conclusion of conference.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Action at the conclusion of conference. 725.417 Section 725.417 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR... § 725.417 Action at the conclusion of conference. (a) At the conclusion of a conference, the...

  16. 39 CFR 963.17 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party who participates in the hearing may, unless the presiding officer orders otherwise, submit proposed findings of fact, conclusions of law, orders,...

  17. 17 CFR 201.340 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Proposed findings, conclusions... findings, conclusions and supporting briefs. (a) Opportunity to file. Before an initial decision is issued... proposed findings and conclusions together with, or as a part of, its brief. (b) Procedure....

  18. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2... Procedures for NRC Adjudications § 2.1209 Findings of fact and conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions of law on the contentions addressed in...

  19. 43 CFR 4.1126 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Proposed findings of fact and conclusions... Appeals Evidentiary Hearings § 4.1126 Proposed findings of fact and conclusions of law. The administrative... and conclusions of law together with a supporting brief at a time designated by the administrative...

  20. 30 CFR 44.31 - Proposed findings of fact, conclusions, and orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Proposed findings of fact, conclusions, and... MANDATORY SAFETY STANDARDS Hearings § 44.31 Proposed findings of fact, conclusions, and orders. After... each party may file proposed findings of fact, conclusions of law, and rule or order, together with...

  1. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... conclusions of law. 351.14 Section 351.14 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY... fact and conclusions of law. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs or memoranda of law, or may be directed by the Copyright Royalty Judges to do so....

  2. 19 CFR 210.63 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 3 2012-04-01 2012-04-01 false Proposed findings and conclusions and briefs. 210... and conclusions and briefs. The administrative law judge shall determine whether and, if so, to what extent the parties shall be permitted to file proposed findings of fact, proposed conclusions of law,...

  3. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Proposed findings and conclusions and briefs. 210....40 Proposed findings and conclusions and briefs. At the time a motion for summary determination under... administrative law judge, any party may file proposed findings of fact and conclusions of law, together...

  4. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... conclusions of law. 351.14 Section 351.14 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY... fact and conclusions of law. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs or memoranda of law, or may be directed by the Copyright Royalty Judges to do so....

  5. 39 CFR 964.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party to a proceeding, except one who fails to answer the..., submit proposed findings of fact, conclusions of law, orders and supporting reasons either in oral...

  6. 21 CFR 1316.64 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Proposed findings of fact and conclusions of law... and conclusions of law. Any party in the hearing may file in quintuplicate proposed findings of fact and conclusions of law within the time fixed by the presiding officer. Any party so filing shall...

  7. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  8. 43 CFR 4.842 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true Proposed findings of fact and conclusions... Posthearing Procedures § 4.842 Proposed findings of fact and conclusions of law. Within 30 days after the... of fact and conclusions of law together with supporting briefs. Such proposals and briefs shall...

  9. 37 CFR 11.53 - Proposed findings and conclusions; post-hearing memorandum.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conclusions; post-hearing memorandum. 11.53 Section 11.53 Patents, Trademarks, and Copyrights UNITED STATES..., Investigations, and Proceedings § 11.53 Proposed findings and conclusions; post-hearing memorandum. Except in... proposed findings and conclusions and a post-hearing memorandum in support of the proposed findings...

  10. 10 CFR 2.1209 - Findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Findings of fact and conclusions of law. 2.1209 Section 2.1209 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND... conclusions of law. Each party shall file written post-hearing proposed findings of fact and conclusions...

  11. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Proposed findings, conclusions and... PENALTIES REGULATIONS Trading With the Enemy Act (TWEA) Penalties § 501.735 Proposed findings, conclusions... writing proposed findings and conclusions. (b) Procedure. Proposed findings of fact must be supported...

  12. 20 CFR 725.417 - Action at the conclusion of conference.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Action at the conclusion of conference. 725.417 Section 725.417 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR... § 725.417 Action at the conclusion of conference. (a) At the conclusion of a conference, the...

  13. 43 CFR 4.452-8 - Findings and conclusions; decision by administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false Findings and conclusions; decision by... Hearings on Appeals Involving Questions of Fact § 4.452-8 Findings and conclusions; decision by administrative law judge. (a) At the conclusion of the testimony the parties at the hearing shall be given...

  14. 34 CFR 101.101 - Posthearing briefs: proposed findings and conclusions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Posthearing briefs: proposed findings and conclusions... Posthearing Procedures, Decisions § 101.101 Posthearing briefs: proposed findings and conclusions. (a) The... fact and conclusions of law, and, if permitted, reply briefs. (b) Briefs should include a summary...

  15. 45 CFR 81.101 - Posthearing briefs: Proposed findings and conclusions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... conclusions. 81.101 Section 81.101 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... § 81.101 Posthearing briefs: Proposed findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of...

  16. 39 CFR 964.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Proposed findings of fact and conclusions of law... findings of fact and conclusions of law. (a) Each party to a proceeding, except one who fails to answer the..., submit proposed findings of fact, conclusions of law, orders and supporting reasons either in oral...

  17. 45 CFR 81.101 - Posthearing briefs: Proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... conclusions. 81.101 Section 81.101 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... § 81.101 Posthearing briefs: Proposed findings and conclusions. (a) The presiding officer shall fix the time for filing posthearing briefs, which may contain proposed findings of fact and conclusions of...

  18. 34 CFR 101.101 - Posthearing briefs: proposed findings and conclusions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Posthearing briefs: proposed findings and conclusions... Posthearing Procedures, Decisions § 101.101 Posthearing briefs: proposed findings and conclusions. (a) The... fact and conclusions of law, and, if permitted, reply briefs. (b) Briefs should include a summary...

  19. 37 CFR 351.14 - Proposed findings of fact and conclusions of law.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... conclusions of law. 351.14 Section 351.14 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY... fact and conclusions of law. (a) Any party to the proceeding may file proposed findings of fact and conclusions, briefs or memoranda of law, or may be directed by the Copyright Royalty Judges to do so....

  20. 31 CFR 501.735 - Proposed findings, conclusions and supporting briefs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Proposed findings, conclusions and... PENALTIES REGULATIONS Trading With the Enemy Act (TWEA) Penalties § 501.735 Proposed findings, conclusions... writing proposed findings and conclusions. (b) Procedure. Proposed findings of fact must be supported...